LOCUS 044_IIG_Bs27_029_SNP 3470472 bp DNA circular UNA 12-JAN-2021 DEFINITION Bacillus subtilis strain Delta6 (hybrid trycycler assembly). ACCESSION urn.local...1ez-cvskbtr VERSION urn.local...1ez-cvskbtr KEYWORDS . SOURCE ORGANISM . FEATURES Location/Qualifiers S_feature complement(3470362..658) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" CDS 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" /label="dnaA CDS" gene 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /label="dnaA gene" promotor_-10 complement(631..649) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(665..670) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1342..1529 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" /label="dnaN CDS" gene 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /label="dnaN gene" downshifts 2650 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" promotor_-35 2731..2735 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752..2771 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2760 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" /label="rlbA CDS" gene 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /label="rlbA gene" CDS 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" /label="recF CDS" gene 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /label="recF gene" misc_feature 3226..3245 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3244 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" /label="remB CDS" gene 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /label="remB gene" CDS 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" /label="gyrB CDS" gene 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /label="gyrB gene" promotor_-10 complement(6003..6021) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6005) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(6037..6042) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6375..6584 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" /label="gyrA CDS" gene 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /label="gyrA gene" promotor_-35 8964..8967 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 8965 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 8984..9001 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9031 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 9095..9101 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9115..9134 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9120..9205 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9120 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 9191..9198 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9207 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 9213..9232 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-16S rRNA" gene 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /label="rrnO-16S gene" tRNA 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ile tRNA" gene 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /label="trnO-Ile gene" tRNA 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ala tRNA" gene 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /label="trnO-Ala gene" rRNA 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-23S rRNA" gene 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /label="rrnO-23S gene" rRNA 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-5S rRNA" gene 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /label="rrnO-5S gene" S_feature 14402..15459 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" /label="yaaC CDS" gene complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /label="yaaC gene" promotor_-35 15438..15445 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15460..15479 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15461 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(15466) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(15475..15486) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15500..15506) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" /label="guaB CDS" gene 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /label="guaB gene" downshifts complement(15510) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(15536..15636) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15576) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(16829..17424) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 16960 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 17018..17022 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17038..17057 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17044..17124 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17044 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" /label="dacA CDS" gene 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /label="dacA gene" promotor_-10 complement(17413..17431) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17424) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(17446..17452) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18338 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" /label="downshifts" S_feature 18457..18565 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18535..18538 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18553..18572 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18567..18652 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18567 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" /label="pdxS CDS" gene 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /label="pdxS gene" S_feature complement(18785..19514) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19502..19520) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19514) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(19536..19541) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" /label="pdxT CDS" gene 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /label="pdxT gene" misc_RNA 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboS RNA" gene 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /label="tboS gene" downshifts 20379 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" /label="downshifts" CDS 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" /label="serS CDS" gene 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /label="serS gene" downshifts 21726 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 21837..21844 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 21859..21878 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 21859 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="upshifts" tRNA 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Ser1 tRNA" gene 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /label="trnSL-Ser1 gene" downshifts 21998 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" /label="downshifts" S_feature 22043..22120 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " /label="dck CDS" gene complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /label="dck gene" promotor_-35 22106..22112 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22111) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 22122..22758 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22122 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 22126..22137 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" /label="dgk CDS" gene complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /label="dgk gene" promotor_-10 complement(23401..23420) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23419) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(23436..23440) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" /label="sleL CDS" gene complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /label="sleL gene" downshifts complement(23496) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(24773..24791) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(24794) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(24807..24812) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" /label="yaaI CDS" gene complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /label="yaaI gene" promotor_-35 25223..25227 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25242..25261 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25246..25442 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25248 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" promotor_-10 complement(25382..25400) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25401) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(25415..25421) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" /label="tadA CDS" gene 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /label="tadA gene" promotor_-35 25932..25938 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25952..25971 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" /label="scr RNA" gene 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /label="scr gene" S_feature 25974..26123 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 25974 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" S_feature 26227..26322 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26279 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 26343..26346 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26370 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" /label="dnaX CDS" gene 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /label="dnaX gene" promotor_-35 27937..27944 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 27959..27978 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 27974 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" /label="ebfC CDS" gene 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /label="ebfC gene" CDS 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" /label="recR CDS" gene 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /label="recR gene" CDS 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" /label="yaaL CDS" gene 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /label="yaaL gene" promotor_-35 29299..29304 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29316 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="upshifts" promotor_-10 29320..29338 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" /label="bofA CDS" gene 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /label="bofA gene" promotor_-35 29639..29646 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 29660..29679 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 29667..29869 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 29667 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-16S" gene 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /label="rrnA-16S gene" tRNA 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ile" gene 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /label="trnA-Ile gene" tRNA 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ala" gene 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /label="trnA-Ala gene" rRNA 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-23S" gene 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /label="rrnA-23S gene" S_feature 34695..34827 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-5S" gene 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /label="rrnA-5S gene" S_feature 34947..35049 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35010..35018 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35032..35051 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35051 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="upshifts" CDS 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" /label="csfB CDS" gene 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /label="csfB gene" downshifts 35300 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" /label="downshifts" promotor_-35 35361..35370 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35382..35397 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35388 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" /label="xpaC CDS" gene 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /label="xpaC gene" CDS 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" /label="yaaN CDS" gene 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /label="yaaN gene" S_feature 37230..37310 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" /label="yaaO CDS" gene 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /label="yaaO gene" promotor_-35 38673..38679 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 38694..38712 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 38703 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="upshifts" CDS 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" /label="tmk CDS" gene 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /label="tmk gene" promotor_-35 39383..39390 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39403..39422 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39414 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" /label="darA CDS" gene 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /label="darA gene" CDS 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" /label="yaaR CDS" gene 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /label="yaaR gene" CDS 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" /label="holB CDS" gene 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /label="holB gene" CDS 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " /label="ricT CDS" gene 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /label="ricT gene" CDS 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" /label="dnaH CDS" gene 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /label="dnaH gene" CDS 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" /label="trmNF CDS" gene 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /label="trmNF gene" CDS 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" /label="yazA CDS" gene 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /label="yazA gene" CDS 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" /label="rsmI CDS" gene 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /label="rsmI gene" downshifts 44363 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" /label="abrB CDS" gene complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /label="abrB gene" downshifts complement(44441) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 44760 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(44796..44815) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(44813) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(44815..44990) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(44829..44836) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(44986..45005) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(44990) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="upshifts" promotor_-35 complement(45019..45026) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45090..45094 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45109..45128 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45115..45223 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45115 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="upshifts" CDS 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" /label="metS CDS" gene 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /label="metS gene" promotor_-10 complement(45972..45991) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45980) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(46007..46011) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47202 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" S_feature complement(47264..49610) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" /label="dayD CDS" gene 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /label="dayD gene" S_feature 48065..48145 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48122..48127 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48143..48161 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48147 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 48172..48175 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48190..48209 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48207 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="upshifts" CDS 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" /label="yabE CDS" gene 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /label="yabE gene" promotor_-35 48240..48247 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48258 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 48262..48281 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49494 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-35 49556..49560 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49576..49595 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49578..49677 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49578 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(49602..49617) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(49618) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(49629..49638) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 49674..49690 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" /label="rnmV CDS" gene 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /label="rnmV gene" upshifts 49688 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" CDS 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" /label="rsmA CDS" gene 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /label="rsmA gene" downshifts 51074 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 51124..51133 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51147..51166 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51149..51270 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51149 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="upshifts" CDS 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" /label="prtG CDS" gene 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /label="prtG gene" downshifts 52130 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 52240..52310 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52301..52308 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52312 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 52322..52341 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52331..52345) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52338) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(52354..52358) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" /label="veg CDS" gene 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /label="veg gene" downshifts 52526 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" /label="downshifts" downshifts 52613 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" /label="downshifts" promotor_-35 52679..52685 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 52699..52710 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 52702..52773 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 52702 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="upshifts" CDS 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" /label="sspF CDS" gene 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /label="sspF gene" downshifts 52944 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(52954..55308) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53037..53041 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53057..53076 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53060 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="upshifts" CDS 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" /label="ispE CDS" gene 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /label="ispE gene" CDS 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" /label="purR CDS" gene 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /label="purR gene" CDS 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" /label="ridA CDS" gene 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /label="ridA gene" downshifts 55253 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(55297..55315) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55298..55406 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55309) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(55331..55336) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55386..55394 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55405..55423 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55408 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="upshifts" CDS 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" /label="spoVG CDS" gene 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /label="spoVG gene" downshifts 55739 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" /label="downshifts" S_feature 55784..55895 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 55877..55881 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 55897..55916 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 55897 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" /label="glmU CDS" gene 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /label="glmU gene" downshifts complement(57288) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" CDS 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" /label="prs CDS" gene 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /label="prs gene" promotor_-35 58302..58308 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58321 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 58323..58341 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" /label="ctc CDS" gene 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /label="ctc gene" downshifts 58972 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" /label="pth CDS" gene 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /label="pth gene" misc_feature 59274..59277 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59280 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" /label="fin CDS" gene 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /label="fin gene" S_feature 59952..60020 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" /label="mfd CDS" gene 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /label="mfd gene" promotor_-35 63572..63578 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 63592..63689 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 63592..63603 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 63592 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" /label="spoVT CDS" gene 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /label="spoVT gene" downshifts 64230 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 64326..64345 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64337 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" /label="yabM CDS" gene 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /label="yabM gene" promotor_-35 65877..65884 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 65899..65918 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 65913 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="upshifts" CDS 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" /label="yabN CDS" gene 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /label="yabN gene" promotor_-35 66637..66644 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 66658..66676 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 66672 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="upshifts" promotor_no_box complement(67060..67160) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67100) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" /label="hslR CDS" gene 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /label="hslR gene" promotor_-35 67733..67738 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 67754..67772 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 67772 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(67804) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" /label="downshifts" CDS 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" /label="spcP CDS" gene 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /label="spcP gene" CDS 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" /label="spcQ CDS" gene 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /label="spcQ gene" promotor_-35 68611..68620 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68633..68648 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68635 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 68667..68675 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68686..68704 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68696 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" /label="divIC CDS" gene 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /label="divIC gene" CDS 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" /label="yabR CDS" gene 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /label="yabR gene" downshifts 69597 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 69711..69718 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69732..69751 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69747 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="upshifts" tRNA 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Met1 tRNA" gene 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /label="trnSL-Met1 gene" tRNA 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu1 tRNA" gene 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /label="trnSL-Glu1 gene" downshifts 69928 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 69973..70084 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70080..70099 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70086 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="upshifts" CDS 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" /label="spoIIE CDS" gene 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /label="spoIIE gene" downshifts 70170 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" /label="downshifts" S_feature complement(70781..71390) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(70807) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(71363..71381) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71389) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(71397..71402) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 71594..71600 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 71615..71633 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 71622 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 72632..72635 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72653..72670 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72656 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="upshifts" CDS 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" /label="yabS CDS" gene 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /label="yabS gene" CDS 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" /label="prkT CDS" gene 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /label="prkT gene" promotor_-35 73948..73954 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 73970..73988 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 73976 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="upshifts" promotor_-35 74446..74453 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74467..74486 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74477 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" /label="tilS CDS" gene 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /label="tilS gene" promotor_-35 75315..75322 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75337..75356 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75340 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" downshifts complement(75933) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" /label="hprT CDS" gene 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /label="hprT gene" upshifts complement(76340) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(76342..76346) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76364..76367) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76478..76574 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" /label="ftsH CDS" gene 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /label="ftsH gene" downshifts 78486 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(78525..78529) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78531..78616 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78533) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 78593..78600 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 78614..78633 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 78618..78682 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 78618 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" /label="coaX CDS" gene 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /label="coaX gene" CDS 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" /label="hslO CDS" gene 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /label="hslO gene" CDS 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" /label="yacD CDS" gene 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /label="yacD gene" promotor_-35 81016..81021 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81038..81056 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81039 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 81285..81292 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81307..81326 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81314 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" /label="cysK CDS" gene 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /label="cysK gene" downshifts 82281 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" /label="downshifts" promotor_-35 82335..82343 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82357..82365 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82359 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 82387..82390 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82405..82424 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82415 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" /label="pabB CDS" gene 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /label="pabB gene" promotor_-35 83257..83259 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83277..83295 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83283 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 83624..83631 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 83644..83663 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 83657 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" /label="pabA CDS" gene 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /label="pabA gene" CDS 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" /label="pabC CDS" gene 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /label="pabC gene" CDS 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" /label="folP CDS" gene 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /label="folP gene" CDS 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" /label="folB CDS" gene 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /label="folB gene" CDS 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" /label="folK CDS" gene 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /label="folK gene" CDS 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" /label="yazB CDS" gene 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /label="yazB gene" CDS 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " /label="dusB CDS" gene 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /label="dusB gene" S_feature complement(87641..89157) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88227..88317 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" /label="lysS CDS" gene 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /label="lysS gene" promotor_-10 complement(89141..89159) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89157) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(89175..89180) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 89798 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 89893..89900 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 89909..90126 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 89909 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 89914..89933 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(89959) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" rRNA 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-16S rRNA" gene 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /label="rrnJ-16S gene" rRNA 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-23S rRNA" gene 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /label="rrnJ-23S gene" rRNA 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-5S rRNA" gene 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /label="rrnJ-5S gene" tRNA 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Val tRNA" gene 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /label="trnJ-Val gene" tRNA 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Thr tRNA" gene 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /label="trnJ-Thr gene" tRNA 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Lys tRNA" gene 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /label="trnJ-Lys gene" tRNA 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu1 tRNA" gene 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /label="trnJ-Leu1 gene" tRNA 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Gly tRNA" gene 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /label="trnJ-Gly gene" tRNA 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu2 tRNA" gene 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /label="trnJ-Leu2 gene" tRNA 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Arg tRNA" gene 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /label="trnJ-Arg gene" tRNA 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Pro tRNA" gene 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /label="trnJ-Pro gene" tRNA 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Ala tRNA" gene 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /label="trnJ-Ala gene" rRNA 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-16S rRNA" gene 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /label="rrnW-16S gene" rRNA 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-23S rRNA" gene 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /label="rrnW-23S gene" rRNA 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-5S rRNA" gene 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /label="rrnW-5S gene" S_feature 100803..100880 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 100850..100853 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100869..100888 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100882 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-35 100916..100922 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 100936..100955 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 100947 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="upshifts" promotor_-35 100962..100969 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100983..101002 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100995 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" /label="ctsR CDS" gene 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /label="ctsR gene" misc_feature complement(101151..101155) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101157) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" /label="mcsA CDS" gene 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /label="mcsA gene" CDS 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" /label="mcsB CDS" gene 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /label="mcsB gene" CDS 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" /label="clpC CDS" gene 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /label="clpC gene" downshifts 105590 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" /label="radA CDS" gene 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /label="radA gene" promotor_-35 106142..106151 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106164..106179 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106167 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" /label="disA CDS" gene 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /label="disA gene" S_feature 108150..108264 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" /label="yacL CDS" gene 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /label="yacL gene" downshifts complement(109187) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" /label="downshifts" CDS 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" /label="ispD CDS" gene 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /label="ispD gene" CDS 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" /label="ispF CDS" gene 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /label="ispF gene" promotor_-35 110551..110558 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110572..110591 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110585 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" /label="gltX CDS" gene 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /label="gltX gene" promotor_-35 111567..111576 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111590..111609 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111590 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="upshifts" S_feature 112090..112390 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " /label="cysE CDS" gene 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /label="cysE gene" CDS 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" /label="cysS CDS" gene 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /label="cysS gene" CDS 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" /label="mrnC CDS" gene 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /label="mrnC gene" CDS 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" /label="rlmB CDS" gene 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /label="rlmB gene" CDS 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" /label="raeA CDS" gene 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /label="raeA gene" promotor_-35 116127..116134 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116149..116168 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116151 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" /label="sigH CDS" gene 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /label="sigH gene" downshifts complement(116645) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" /label="downshifts" S_feature 116848..116939 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" /label="rpmGB CDS" gene 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /label="rpmGB gene" CDS 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" /label="secE CDS" gene 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /label="secE gene" S_feature 117303..117480 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117474) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" /label="nusG CDS" gene 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /label="nusG gene" upshifts complement(117569) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(117572..117576) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(117591..117596) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118025..118032 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118043..118181 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118043 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 118046..118065 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" /label="rplK CDS" gene 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /label="rplK gene" S_feature 118608..118701 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" /label="rplA CDS" gene 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /label="rplA gene" downshifts complement(119374) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" /label="ldlJ RNA" gene 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /label="ldlJ gene" upshifts complement(119462) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(119465..119469) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119518 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" /label="downshifts" CDS 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" /label="rplJ CDS" gene 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /label="rplJ gene" CDS 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" /label="rplL CDS" gene 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /label="rplL gene" downshifts 120485 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" /label="downshifts" downshifts 120558 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" /label="downshifts" CDS 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" /label="rlmG CDS" gene 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /label="rlmG gene" promotor_-35 121259..121263 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121277..121509 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121277 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 121279..121298 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" /label="rpoB CDS" gene 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /label="rpoB gene" promotor_-10 complement(123095..123114) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123098) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123128..123137) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(123966..123970) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123971) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123985..123991) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" /label="rpoC CDS" gene 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /label="rpoC gene" downshifts complement(128217) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" upshifts complement(128371) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(128389..128390) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(128701) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 128753..128874 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 128856..128863 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 128876 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 128877..128896 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(128894..128898) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(128897) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" /label="rulS CDS" gene 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /label="rulS gene" S_feature 129180..129292 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" /label="rpsL CDS" gene 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /label="rpsL gene" CDS 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" /label="rpsG CDS" gene 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /label="rpsG gene" CDS 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" /label="fusA CDS" gene 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /label="fusA gene" S_feature 132354..132472 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" /label="tufA CDS" gene 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /label="tufA gene" downshifts 133658 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" /label="downshifts" misc_feature complement(133689..133692) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(133693) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 133719..133738 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 133727 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" /label="ybaC CDS" gene 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /label="ybaC gene" promotor_-35 134725..134732 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 134746..134765 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 134761..134954 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 134761 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" /label="rpsJ CDS" gene 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /label="rpsJ gene" CDS 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" /label="rplC CDS" gene 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /label="rplC gene" CDS 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" /label="rplD CDS" gene 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /label="rplD gene" CDS 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" /label="rplW CDS" gene 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /label="rplW gene" CDS 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" /label="rplB CDS" gene 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /label="rplB gene" downshifts complement(137038) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" CDS 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" /label="rpsS CDS" gene 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /label="rpsS gene" CDS 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" /label="rplV CDS" gene 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /label="rplV gene" CDS 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" /label="rpsC CDS" gene 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /label="rpsC gene" downshifts complement(138446) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(138527..138531) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138534) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(138548..138550) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" /label="rplP CDS" gene 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /label="rplP gene" CDS 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" /label="rpmC CDS" gene 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /label="rpmC gene" CDS 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" /label="rpsQ CDS" gene 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /label="rpsQ gene" CDS 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" /label="rplNA CDS" gene 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /label="rplNA gene" CDS 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" /label="rplX CDS" gene 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /label="rplX gene" CDS 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" /label="rplE CDS" gene 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /label="rplE gene" CDS 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" /label="rpsNA CDS" gene 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /label="rpsNA gene" CDS 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" /label="rpsH CDS" gene 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /label="rpsH gene" downshifts complement(141966) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" /label="downshifts" CDS 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" /label="rplF CDS" gene 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /label="rplF gene" CDS 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" /label="rplR CDS" gene 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /label="rplR gene" CDS 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" /label="rpsE CDS" gene 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /label="rpsE gene" CDS 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" /label="rpmD CDS" gene 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /label="rpmD gene" CDS 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" /label="rplO CDS" gene 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /label="rplO gene" CDS 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" /label="secY CDS" gene 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /label="secY gene" CDS 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " /label="adk CDS" gene 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /label="adk gene" CDS 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" /label="mapA CDS" gene 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /label="mapA gene" CDS 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" /label="ybzG CDS" gene 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /label="ybzG gene" CDS 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" /label="infA CDS" gene 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /label="infA gene" CDS 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" /label="rpmJ CDS" gene 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /label="rpmJ gene" CDS 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" /label="rpsM CDS" gene 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /label="rpsM gene" CDS 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" /label="rpsK CDS" gene 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /label="rpsK gene" S_feature 148346..148521 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" /label="rpoA CDS" gene 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /label="rpoA gene" CDS 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" /label="rplQ CDS" gene 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /label="rplQ gene" downshifts 149908 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" /label="downshifts" S_feature 149953..150033 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" /label="ecfA CDS" gene 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /label="ecfA gene" CDS 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" /label="ecfAB CDS" gene 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /label="ecfAB gene" CDS 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" /label="ecfT CDS" gene 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /label="ecfT gene" CDS 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" /label="truA CDS" gene 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /label="truA gene" S_feature complement(152630..153098) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 152763..152768 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 152783..152800 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 152802 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(153098..153117) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153120) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(153130..153139) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153291..153297 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153312..153331 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153316 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" /label="ldlM RNA" gene 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /label="ldlM gene" CDS 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" /label="rplM CDS" gene 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /label="rplM gene" CDS 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" /label="rpsI CDS" gene 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /label="rpsI gene" downshifts 154258 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" /label="downshifts" promotor_-35 154400..154407 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154421..154440 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154429..154710 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154429 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature 154709..154728 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 154712 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" /label="ybaJ CDS" gene 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /label="ybaJ gene" downshifts 155505 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 155644..155650 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 155665..155676 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 155672 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" /label="ybaK CDS" gene 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /label="ybaK gene" promotor_-35 156143..156148 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156164..156182 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156165 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" /label="cwlD CDS" gene 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /label="cwlD gene" upshifts 156961 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="upshifts" misc_feature 156964..156983 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" /label="salA CDS" gene 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /label="salA gene" S_feature complement(157641..158105) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158056 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" /label="downshifts" S_feature 158101..158772 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" /label="gerD CDS" gene complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /label="gerD gene" promotor_-10 complement(158695..158706) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(158707) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(158720..158726) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(158740..159369) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" /label="kbaA CDS" gene 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /label="kbaA gene" S_feature 159370..160264 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" /label="pdaB CDS" gene complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /label="pdaB gene" promotor_-10 complement(160165..160183) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160185) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(160199..160204) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160242..160249 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160264..160283 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160266..160483 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160266 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-16S rRNA" gene 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /modified_by="User" /label="rrnI-16S gene" Polymorphism join(160830,160832) /Source="geneious" /ID="SNP_BsDelta6_161240_161239" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=45 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value="4.2e-57" /Variant_Raw_Frequency=41 /comment="rrnI-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-23S rRNA" gene 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /label="rrnI-23S gene" rRNA 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-5S rRNA" gene 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /label="rrnI-5S gene" Polymorphism join(165341,165342) /Source="geneious" /ID="SNP_BsDelta6_165748_165749" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="-TC" /Codon_Change /Coverage="172 -> 174" /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TC" /Variant_Nucleotides /Variant_P_Value="1.5e-307" /Variant_Raw_Frequency=152 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(165342,165344) /Source="geneious" /ID="SNP_BsDelta6_165751_165751" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="C -> T" /Codon_Change /Coverage=172 /locus_tag /Protein_Effect /Reference_Frequency="1.2%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=168 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Asn tRNA" gene 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /label="trnI-Asn gene" Polymorphism join(165417,165419) /Source="geneious" /ID="SNP_BsDelta6_165826_165825" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=163 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=160 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Thr tRNA" gene 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /label="trnI-Thr gene" tRNA 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Gly tRNA" gene 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /label="trnI-Gly gene" Polymorphism join(165630,165632) /Source="geneious" /ID="SNP_BsDelta6_166038_166037" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="T" /Codon_Change /Coverage=154 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=148 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Arg tRNA" gene 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /label="trnI-Arg gene" tRNA 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Pro tRNA" gene 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /label="trnI-Pro gene" tRNA 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Ala tRNA" gene 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /label="trnI-Ala gene" Polymorphism join(165937,165938) /Source="geneious" /ID="SNP_BsDelta6_166344_166344" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-G" /Codon_Change /Coverage=132 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides /Variant_P_Value="4.9e-75" /Variant_Raw_Frequency=130 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-16S rRNA" gene 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /label="rrnH-16S gene" rRNA 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-23S rRNA" gene 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /label="rrnH-23S gene" rRNA 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-5S rRNA" gene 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /label="rrnH-5S gene" rRNA 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-16S rRNA" gene 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /label="rrnG-16S gene" rRNA 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-23S rRNA" gene 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /label="rrnG-23S gene" rRNA 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-5S rRNA" gene 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /label="rrnG-5S gene" S_feature 175915..176523 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176491..176495 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176511..176530 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176525..176681 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176525 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="upshifts" CDS 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" /label="ybaR CDS" gene 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /label="ybaR gene" downshifts 178107 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 178161..178166 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178179..178198 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178197 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="upshifts" CDS 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" /label="ybaS CDS" gene 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /label="ybaS gene" downshifts 179165 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" /label="eesA CDS" gene complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /label="eesA gene" downshifts complement(179218) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" /label="feuC CDS" gene complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /label="feuC gene" CDS complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" /label="feuB CDS" gene complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /label="feuB gene" CDS complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" /label="feuA CDS" gene complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /label="feuA gene" promotor_-35 182282..182288 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182303..182321 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182312 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(182953..182972) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(182960) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" /label="btr CDS" gene complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /label="btr gene" promotor_-10 complement(184643..184662) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(184655) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(184677..184684) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(184764) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" /label="ybbC CDS" gene complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /label="ybbC gene" downshifts complement(184814) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" /label="downshifts" CDS complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" /label="nagZ CDS" gene complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /label="nagZ gene" CDS complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" /label="amiE CDS" gene complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /label="amiE gene" CDS complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" /label="murP CDS" gene complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /label="murP gene" CDS complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" /label="murR CDS" gene complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /label="murR gene" CDS complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" /label="murQ CDS" gene complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /label="murQ gene" promotor_-10 complement(192595..192613) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(192608) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(192629..192636) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" /label="ybbJ CDS" gene complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /label="ybbJ gene" CDS complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" /label="ybbK CDS" gene complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /label="ybbK gene" promotor_-10 complement(193650..193669) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193671) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(193684..193685) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 193744..193751 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 193766..193785 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 193777 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" tRNA 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu2 tRNA" gene 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /label="trnSL-Glu2 gene" tRNA 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val1 tRNA" gene 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /label="trnSL-Val1 gene" tRNA 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Thr1 tRNA" gene 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /label="trnSL-Thr1 gene" tRNA 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Tyr1 tRNA" gene 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /label="trnSL-Tyr1 gene" tRNA 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gln2 tRNA" gene 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /label="trnSL-Gln2 gene" downshifts 194223 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 194268..194385 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194386..194395 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194387 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" promotor_-10 194407..194422 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" /label="sigW CDS" gene 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /label="sigW gene" CDS 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" /label="rsiW CDS" gene 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /label="rsiW gene" downshifts complement(195443) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(195601..195701) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 195631 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" upshifts complement(195641) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 195700..195707 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 195722..195741 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 195731..195811 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 195731 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="upshifts" CDS 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" /label="cdaA CDS" gene 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /label="cdaA gene" CDS 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" /label="cdaR CDS" gene 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /label="cdaR gene" CDS 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" /label="glmM CDS" gene 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /label="glmM gene" downshifts 199437 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 199461..199469 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199477 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 199483..199502 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199529..199534 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199550..199569 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199556 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_feature 199600..199616 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 199613 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" /label="glmSA RNA" gene 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /label="glmSA gene" S_feature 199787..199875 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" /label="glmS CDS" gene 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /label="glmS gene" S_feature complement(201401..>201681) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 201664 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" /label="downshifts" SCAR join(201681,201727) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta4" N_region 201682..201726 /note="insertion of 45 bases of unknown origin" /modified_by="User" /label="Delta4" S_feature <201727..201845 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" /label="ybdG CDS" gene 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /label="ybdG gene" CDS 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" /label="ybdJ CDS" gene 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /label="ybdJ gene" promotor_-35 203390..203396 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203410..203429 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203428 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" /label="ybdK CDS" gene 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /label="ybdK gene" promotor_-35 204491..204493 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204509..204528 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 204512 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" /label="ybzI CDS" gene 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /label="ybzI gene" downshifts 204742 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" /label="ybdM CDS" gene complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /label="ybdM gene" CDS complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" /label="ybdN CDS" gene complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /label="ybdN gene" downshifts complement(205664) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(205713..205732) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(205746..205755) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(205748) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(206512..206531) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(206537) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(206546..206553) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 206567..206574 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 206588..206606 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 206590 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="upshifts" CDS 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" /label="ybdO CDS" gene 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /label="ybdO gene" downshifts 207801 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" promotor_-35 207969..207975 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 207989..208008 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 208003..208132 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 208003 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="upshifts" CDS 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" /label="ybxG CDS" gene 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /label="ybxG gene" downshifts 209529 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" promotor_-35 209567..209573 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 209587..209598 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 209588 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="upshifts" CDS 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" /label="csgA CDS" gene 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /label="csgA gene" CDS 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" /label="ybxH CDS" gene 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /label="ybxH gene" downshifts 210071 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" /label="ybxI CDS" gene complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /label="ybxI gene" promotor_-10 complement(210941..210959) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(210949) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(210970..210978) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211033..211039 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211054..211072 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211060 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="upshifts" CDS 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" /label="cypC CDS" gene 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /label="cypC gene" misc_feature 211404..211411 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 211414 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 212338 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" /label="ybyB CDS" gene complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /label="ybyB gene" downshifts complement(212405) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(212676..212694) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(212685) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(212708..212714) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 212838..212845 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 212855 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 212861..212880 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" /label="ybeC CDS" gene 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /label="ybeC gene" downshifts 214517 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" /label="glpQA CDS" gene complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /label="glpQA gene" downshifts complement(214592) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(215505) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(215514..215530) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(215539..215545) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" /label="glpT CDS" gene complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /label="glpT gene" promotor_-35 216543..216552 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 216565..217191 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 216565..216584 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216565 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216896..216968) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(216928..217028) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(216968) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216970..217056) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(217046..217065) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(217060) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(217078..217085) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" /label="ybeF CDS" gene 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /label="ybeF gene" promotor_-35 217464..217471 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 217471 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 217487..217506 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" /label="ybfA CDS" gene 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /label="ybfA gene" CDS 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" /label="ybfB CDS" gene 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /label="ybfB gene" downshifts 219686 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" /label="ybfEc CDS" gene complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo /label="ybfEc gene" downshifts complement(219784) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" /label="ybfEn CDS" gene complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo /label="ybfEn gene" S_feature complement(220016..220136) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(220121..220139) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(220136) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(220138..220210) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(220156..220161) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" /label="ybfF CDS" gene complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /label="ybfF gene" S_feature complement(221123..221210) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" /label="ybfG CDS" gene complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /label="ybfG gene" misc_feature complement(223444..223462) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(223456) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" /label="ybfH CDS" gene complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /label="ybfH gene" CDS complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " /label="ybfI CDS" gene complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /label="ybfI gene" misc_feature complement(225255..225274) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(225262) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 225402..225405 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 225420..225439 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 225425 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="upshifts" CDS 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" /label="purT CDS" gene 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /label="purT gene" downshifts 226594 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 226633..226634 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_026" CDS 226647..227522 /gene="cesB" /locus_tag="PG10_pseudo_BSU02260" /old_locus_tag="BSU_02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /modified_by="User" /translation="MQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKTHIIAS GPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAMETRADF AEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFISFHPDV YKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTENGFPYV FTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLSLEQPE YVNQRVLSFLCGGIK*" /label="PG10_pseudo_BSU02260" gene 226647..227522 /gene="cesB" /locus_tag="PG10_pseudo_BSU02260" /old_locus_tag="BSU_02260" /modified_by="User" /label="PG10_pseudo_BSU02260" promotor_-35 226866..226873 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 226882 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 226887..226905 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 227523..227717 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 227718..228251 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" /label="pssA CDS" gene 227718..228251 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /label="pssA gene" CDS 228242..228730 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" /label="ybfM CDS" gene 228242..228730 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /label="ybfM gene" CDS 228723..229514 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" /label="psd CDS" gene 228723..229514 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /label="psd gene" downshifts 229489 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 229569..229847 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" /label="ybfN CDS" gene 229569..229847 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /label="ybfN gene" promotor_-35 229890..229899 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 229908 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 229912..229927 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 229953..231293 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" /label="ybfO CDS" gene 229953..231293 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /label="ybfO gene" downshifts 231293 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" upshifts 231359 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="upshifts" misc_feature 231362..231381 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 231401..232288 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" /label="ybfP CDS" gene 231401..232288 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /label="ybfP gene" S_feature 232289..232432 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 232404..232411 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 232425..232444 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 232434 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 232488..233456 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" /label="ybfQ CDS" gene 232488..233456 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /label="ybfQ gene" promotor_-10 complement(233310..233328) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(233327) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(233344..233349) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 233453 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" /label="downshifts" downshifts complement(233492) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(233492..234736) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" /label="gltP CDS" gene complement(233492..234736) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /label="gltP gene" promotor_-10 complement(234770..234788) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234779) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234799..234807) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(234807..234825) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234823) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234841..234846) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(234881..236776) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" /label="gamP CDS" gene complement(234881..236776) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /label="gamP gene" downshifts complement(234897) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" misc_feature 236642..236661 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 236659 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(236797..237546) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" /label="gamA CDS" gene complement(236797..237546) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /label="gamA gene" S_feature 237519..237700 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(237547..237617) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(237606..237625) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(237621) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(237641..237648) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 237687..237694 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 237702 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 237707..237726 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 237765..238472 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" /label="gamR CDS" gene 237765..238472 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /label="gamR gene" promotor_-35 238438..238439 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 238455..238469 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 238465 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="upshifts" CDS 238506..238781 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" /label="ybgB CDS" gene 238506..238781 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /label="ybgB gene" promotor_-10 complement(238564..238582) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(238570) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(238597..238603) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 238773 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 238824..238828 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 238844..238863 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 238850 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="upshifts" S_feature 238861..238989 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 238990..240060 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" /label="ilvE CDS" gene 238990..240060 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /label="ilvE gene" downshifts 240049 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(240097..241509) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" /label="ybgF CDS" gene complement(240097..241509) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /label="ybgF gene" downshifts complement(240114) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(241510..241621) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(241594..241613) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(241621) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(241628..241635) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(241630..242577) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" /label="ybgG CDS" gene complement(241630..242577) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /label="ybgG gene" promotor_-10 complement(242615..242634) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(242632) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="upshifts" promotor_-35 complement(242649..242656) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(242706..244142) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" /label="glnT CDS" gene complement(242706..244142) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /label="glnT gene" downshifts complement(242721) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" /label="downshifts" CDS complement(244165..245148) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" /label="glsA CDS" gene complement(244165..245148) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /label="glsA gene" promotor_-10 complement(245242..245259) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 245247..245266 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(245249) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 245253 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(245275..245282) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 245450..246682 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" /label="glnJ CDS" gene 245450..246682 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /label="glnJ gene" CDS 246693..247637 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" /label="glnL CDS" gene 246693..247637 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /label="glnL gene" downshifts 247614 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" promotor_-35 247734..247741 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 247746..247863 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 247746 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 247755..247774 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 247864..248790 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" /label="kdgD CDS" gene 247864..248790 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /label="kdgD gene" CDS 248820..250286 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" /label="gucD CDS" gene 248820..250286 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /label="gucD gene" CDS 250370..251737 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" /label="gudP CDS" gene 250370..251737 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /label="gudP gene" CDS 251774..253141 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" /label="gudD CDS" gene 251774..253141 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /label="gudD gene" promotor_-35 253155..253162 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 253177..253194 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 253180 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="upshifts" CDS 253211..253912 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" /label="garR CDS" gene 253211..253912 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /label="garR gene" downshifts 253862 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" downshifts 253906 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS 254003..255535 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" /label="garD CDS" gene 254003..255535 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /label="garD gene" promotor_-35 255547..255550 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 255565..255584 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 255577..255811 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 255577 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 255812..256732 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" /label="ycbJ CDS" gene 255812..256732 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /label="ycbJ gene" promotor_-35 256734..256741 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 256756..256775 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 256766 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 256789..257036 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" /label="tboW RNA" gene 256789..257036 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /label="tboW gene" downshifts 257005 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS 257134..257295 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" /label="rtpA CDS" gene 257134..257295 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /label="rtpA gene" promotor_no_box 257212..257312 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 257272 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 257316..258254 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" /label="ycbK CDS" gene 257316..258254 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /label="ycbK gene" downshifts 257360 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 258277..258296 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 258282..258350 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 258282 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="upshifts" CDS 258351..259031 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" /label="ycbL CDS" gene 258351..259031 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /label="ycbL gene" CDS 259033..259968 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" /label="ycbM CDS" gene 259033..259968 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /label="ycbM gene" CDS 260060..260983 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" /label="ycbN CDS" gene 260060..260983 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /label="ycbN gene" S_feature complement(260530..261714) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 261002..261688 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" /label="ycbO CDS" gene 261002..261688 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /label="ycbO gene" CDS complement(261649..261783) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" /label="hypothetical protein CDS" gene complement(261649..261783) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /label="gene" downshifts 261683 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" CDS complement(261743..262129) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" /label="ycbP CDS" gene complement(261743..262129) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /label="ycbP gene" downshifts complement(261759) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(262155..262173) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(262174) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(262187..262193) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(262207..263205) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(262250) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" /label="downshifts" promotor_-35 262386..262391 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 262405 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 262407..262425 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(262419) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(262421..262435) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(262441) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 complement(262443..262447) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 262443..262871 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" /label="cwlJ CDS" gene 262443..262871 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /label="cwlJ gene" downshifts 262850 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 262916..262922 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 262935..262954 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 262937 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="upshifts" CDS 262977..263708 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" /label="ycbR CDS" gene 262977..263708 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /label="ycbR gene" promotor_-10 complement(263179..263198) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(263205) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(263212..263219) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 263626 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 263790..263966 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" /label="yczK CDS" gene 263790..263966 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /label="yczK gene" promotor_-35 263918..263924 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 263931..263948 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 263942 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="upshifts" CDS 263985..265736 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" /label="phoD CDS" gene 263985..265736 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /label="phoD gene" promotor_-10 complement(264039..264054) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264045) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(264067..264076) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 265749..265961 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" /label="tatAD CDS" gene 265749..265961 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /label="tatAD gene" S_feature 265962..266021 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 266022..266750 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" /label="tatCD CDS" gene 266022..266750 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /label="tatCD gene" downshifts complement(266030) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(266747..267394) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" /label="pcp CDS" gene complement(266747..267394) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /label="pcp gene" promotor_-10 complement(267409..267428) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 267422..267428 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(267423) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(267443..267447) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 267443..267462 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 267445 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="upshifts" CDS 267473..268585 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" /label="ycbU CDS" gene 267473..268585 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /label="ycbU gene" upshifts complement(267819) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(267822..267841) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(267857..267861) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 268579 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(268627..270066) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" /label="lmrB CDS" gene complement(268627..270066) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /label="lmrB gene" downshifts complement(268634) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(270106..270672) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" /label="lmrA CDS" gene complement(270106..270672) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /label="lmrA gene" promotor_-10 complement(270710..270729) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(270724) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(270744..270751) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 270826..270832 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 270848..270865 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 270854 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="upshifts" CDS 270889..272016 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" /label="ansZ CDS" gene 270889..272016 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /label="ansZ gene" downshifts 271989 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 272113..272119 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 272133..272152 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 272133 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 272179..272817 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" /label="estA CDS" gene 272179..272817 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /label="estA gene" downshifts 272803 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" /label="downshifts" S_feature 272848..273438 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(272855..273238) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" /label="yczC CDS" gene complement(272855..273238) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /label="yczC gene" downshifts complement(272879) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" Polymorphism join(273052,273054) /Source="geneious" /ID="SNP_BsDelta6_293079_293079" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=186 /Change="C -> T" /Codon_Change="CTG -> CTA" /Coverage=154 /locus_tag="BSU_02710" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" promotor_-10 complement(273268..273287) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(273275) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(273301..273308) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 273410..273413 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 273429..273448 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 273440 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 273473..274549 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" /label="yccF CDS" gene 273473..274549 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /label="yccF gene" downshifts 274543 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(274589..275545) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" /label="natK CDS" gene complement(274589..275545) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /label="natK gene" downshifts complement(274617) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(275558..276259) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" /label="natR CDS" gene complement(275558..276259) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /label="natR gene" promotor_-10 complement(276283..276302) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(276289) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(276318..276321) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 276339..276342 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 276358..276377 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 276368 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 276403..277143 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" /label="natA CDS" gene 276403..277143 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /label="natA gene" CDS 277144..278304 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" /label="natB CDS" gene 277144..278304 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /label="natB gene" promotor_-35 278355..278363 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 278375..278393 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 278375 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 278440..279372 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" /label="yccK CDS" gene 278440..279372 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /label="yccK gene" CDS complement(279412..280476) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" /label="ycdA CDS" gene complement(279412..280476) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /label="ycdA gene" downshifts complement(279413) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(280477..280667) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(280499..280630) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " /label="hypothetical protein CDS" gene complement(280499..280630) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /label="gene" promotor_-10 complement(280652..280671) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(280672) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(280686..280693) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 280804..282222 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" /label="ycdB CDS" gene 280804..282222 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /label="ycdB gene" promotor_-10 complement(282265..282283) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282273) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(282297..282304) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 282329..282408 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 282329 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="upshifts" promotor_-35 282331..282337 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 282352..282369 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 282409..283770 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" /label="ycdC CDS" gene 282409..283770 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /label="ycdC gene" S_feature 283771..284351 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(283778..284281) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" /label="cwlK CDS" gene complement(283778..284281) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /label="cwlK gene" S_feature complement(284282..284363) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 284353 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="upshifts" promotor_-10 complement(284355..284374) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 284356..284375 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(284364) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="upshifts" CDS 284404..285525 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" /label="rapJ CDS" gene 284404..285525 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /label="rapJ gene" downshifts 285519 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 285566..285572 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 285587..285605 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 285590 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 285632..286408 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" /label="ycdF CDS" gene 285632..286408 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /label="ycdF gene" downshifts complement(285639) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" /label="downshifts" CDS 286433..288118 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" /label="ycdG CDS" gene 286433..288118 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /label="ycdG gene" promotor_no_box 287373..287473 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 287433 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 287499 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" /label="downshifts" downshifts 288115 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" promotor_-35 288209..288216 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 288232..288251 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 288238 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 288306..289265 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" /label="znuA CDS" gene 288306..289265 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /label="znuA gene" promotor_-35 288861..288867 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 288881..288900 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 288885 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" downshifts 289237 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS 289321..290016 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" /label="znuC CDS" gene 289321..290016 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /label="znuC gene" CDS 289974..290816 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" /label="znuB CDS" gene 289974..290816 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /label="znuB gene" downshifts 290803 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(290854..291849) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" /label="yceB CDS" gene complement(290854..291849) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /label="yceB gene" promotor_-35 291805..291812 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 291827..291846 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 291833..292035 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 291833 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="upshifts" promotor_-10 complement(291881..291900) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(291889) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(291915..291922) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 292019..292028 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 292037..292132 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 292037 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 292041..292056 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 292133..292732 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" /label="yceC CDS" gene 292133..292732 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /label="yceC gene" CDS 292754..293335 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" /label="yceD CDS" gene 292754..293335 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /label="yceD gene" CDS 293370..293948 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" /label="yceE CDS" gene 293370..293948 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /label="yceE gene" CDS 293999..294772 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" /label="yceF CDS" gene 293999..294772 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /label="yceF gene" downshifts 294759 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" /label="downshifts" CDS 294857..296470 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" /label="yceG CDS" gene 294857..296470 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /label="yceG gene" CDS 296486..297577 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" /label="yceH CDS" gene 296486..297577 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /label="yceH gene" downshifts 297551 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" /label="downshifts" promotor_-35 297631..297638 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 297653..297672 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 297661 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="upshifts" CDS 297699..298901 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" /label="niaP CDS" gene 297699..298901 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /label="niaP gene" downshifts 298881 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(299154..300326) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" /label="yceJ CDS" gene complement(299154..300326) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /label="yceJ gene" downshifts complement(299169) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(300395..300697) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" /label="yceK CDS" gene complement(300395..300697) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /label="yceK gene" downshifts complement(300423) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(300680..300699) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(300699) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(300713..300719) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 300946..300965 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 300946 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="upshifts" CDS 300987..302243 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" /label="opuAA CDS" gene 300987..302243 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /label="opuAA gene" downshifts complement(300995) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" /label="downshifts" CDS 302245..303093 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" /label="opuAB CDS" gene 302245..303093 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /label="opuAB gene" CDS 303093..303974 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" /label="opuAC CDS" gene 303093..303974 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /label="opuAC gene" downshifts 303955 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(303987) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(304012..305163) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" /label="amhX CDS" gene complement(304012..305163) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /label="amhX gene" downshifts complement(304031) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" S_feature complement(305164..305251) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 305219..305226 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(305238..305257) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 305241..305260 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(305251) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="upshifts" upshifts 305254 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="upshifts" promotor_-35 complement(305270..305276) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 305313..306746 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" /label="ycgA CDS" gene 305313..306746 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /label="ycgA gene" promotor_-35 306051..306059 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 306071..306089 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 306090 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 306728 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 306789..306796 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 306811..306830 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 306820 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 306862..307443 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" /label="ycgB CDS" gene 306862..307443 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /label="ycgB gene" upshifts 307256 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" misc_feature 307260..307264 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 307419..307426 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 307441..307460 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 307454..307591 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 307454 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 307592..309571 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" /label="amyE CDS" gene 307592..309571 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /label="amyE gene" downshifts 309585 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 309651..309658 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 309668 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 309672..309691 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 309748..310713 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" /label="lctE CDS" gene 309748..310713 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /label="lctE gene" CDS 310745..312370 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" /label="lctP CDS" gene 310745..312370 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /label="lctP gene" downshifts 310751 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" /label="downshifts" downshifts 312357 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(312415..313953) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" /label="mdr CDS" gene complement(312415..313953) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /label="mdr gene" downshifts complement(312433) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(313007..313107) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(313047) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 313967..313971 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 313987..314006 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 314001 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(314033..314052) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(314036) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="upshifts" CDS 314066..314530 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" /label="ycgE CDS" gene 314066..314530 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /label="ycgE gene" promotor_-35 complement(314067..314073) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 314540..314545 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 314561..314579 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 314571 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 314604..315233 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" /label="ycgF CDS" gene 314604..315233 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /label="ycgF gene" promotor_-35 315244..315253 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 315267..315286 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 315275 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 315303..316064 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" /label="ycgG CDS" gene 315303..316064 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /label="ycgG gene" S_feature complement(315703..316065) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 316061 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(316066..317406) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" /label="ycgH CDS" gene complement(316066..317406) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /label="ycgH gene" promotor_-10 complement(317433..317444) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(317443) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(317459..317465) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 317485..317491 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 317499 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 317506..317517 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 317536..318132 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" /label="ycgI CDS" gene 317536..318132 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /label="ycgI gene" promotor_-35 318140..318147 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 318161..318261 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 318161..318180 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 318161 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(318257) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS 318262..319080 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" /label="nadE CDS" gene 318262..319080 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /label="nadE gene" downshifts 319062 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" /label="downshifts" CDS complement(319130..319723) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" /label="tmrB CDS" gene complement(319130..319723) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /label="tmrB gene" downshifts complement(319137) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(319738..319757) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(319753) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(319772..319775) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(319781..319929) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 319831..319838 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 319851..319870 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 319853..319961 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 319855 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(319923..319941) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 319929..319936 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(319939) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 319951..319970 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(319957..319962) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 319963 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="upshifts" CDS 319999..320559 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" /label="aroK CDS" gene 319999..320559 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /label="aroK gene" downshifts 320536 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(320587..321348) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" /label="ycgJ CDS" gene complement(320587..321348) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /label="ycgJ gene" downshifts complement(320611) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(321380..321399) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 321381..321388 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(321386) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 321403..321422 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(321414..321419) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 321415 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" CDS 321466..322440 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" /label="ycgK CDS" gene 321466..322440 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /label="ycgK gene" S_feature 322441..322511 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 322512..323468 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" /label="cah CDS" gene 322512..323468 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /label="cah gene" promotor_-35 322927..322933 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 322948..322959 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 322955 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" S_feature 323469..323547 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 323522..323527 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 323544..323562 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 323549 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" CDS 323552..324334 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" /label="ycgL CDS" gene 323552..324334 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /label="ycgL gene" downshifts 324299 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 324344..324471 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 324448..324452 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 324467..324486 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 324473 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 324525..325436 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" /label="putB CDS" gene 324525..325436 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /label="putB gene" CDS 325453..327000 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" /label="putC CDS" gene 325453..327000 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /label="putC gene" promotor_-35 326424..326430 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326444..326463 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326452 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 326535..326541 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326554..326573 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326563 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" misc_feature 326999..327003 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 327001..327123 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 327003 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 327124..328545 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" /label="putP CDS" gene 327124..328545 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /label="putP gene" S_feature complement(327644..329499) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 328525 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" /label="downshifts" S_feature 328570..328666 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 328637..328644 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328659..328678 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328668 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 328698..329933 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" /label="putR CDS" gene 328698..329933 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /label="putR gene" promotor_-10 complement(329492..329510) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(329509) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(329524..329531) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(329917) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(329970..330827) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" /label="ycgQ CDS" gene complement(329970..330827) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /label="ycgQ gene" downshifts complement(329983) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(330832..331716) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" /label="ycgR CDS" gene complement(330832..331716) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /label="ycgR gene" upshifts complement(331768) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(331773..331786) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(331801..331809) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(331816..332670) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" /label="ycgS CDS" gene complement(331816..332670) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /label="ycgS gene" promotor_-10 complement(332689..332708) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(332709) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="upshifts" promotor_-35 complement(332723..332726) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 332760..332779 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(332760..332778) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 332767..332831 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 332768 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(332777) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(332794..332799) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 332832..333842 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" /label="ffoR CDS" gene 332832..333842 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /label="ffoR gene" S_feature 333843..336290 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(333874..335325) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" /label="nasF CDS" gene complement(333874..335325) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /label="nasF gene" downshifts complement(333878) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(335386..335706) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" /label="nasE CDS" gene complement(335386..335706) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /label="nasE gene" promotor_-35 335557..335562 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 335576..335580 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 335583 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(335615) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(335617..335636) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(335650..335657) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(335738..338155) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" /label="nasD CDS" gene complement(335738..338155) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /label="nasD gene" promotor_-10 complement(338180..338199) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(338194) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(338211..338217) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(338277..340409) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" /label="nasC CDS" gene complement(338277..340409) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /label="nasC gene" CDS complement(340416..342731) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" /label="nasB CDS" gene complement(340416..342731) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /label="nasB gene" promotor_no_box complement(342750..342850) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(342790) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 342833..342840 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 342854..342873 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 342866 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="upshifts" CDS 342911..344116 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" /label="nasA CDS" gene 342911..344116 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /label="nasA gene" downshifts 344101 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 344160..344166 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 344181..344200 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 344189 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="upshifts" CDS 344233..345147 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" /label="folEB CDS" gene 344233..345147 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /label="folEB gene" CDS 345144..345728 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" /label="yciB CDS" gene 345144..345728 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /label="yciB gene" promotor_-35 345739..345746 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 345760..345779 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 345770 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="upshifts" CDS 345824..346009 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" /label="yczL CDS" gene 345824..346009 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /label="yczL gene" CDS 346037..347230 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" /label="zinU CDS" gene 346037..347230 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /label="zinU gene" downshifts 347222 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" S_feature 347267..348936 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(347279..347959) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" /label="yckA CDS" gene complement(347279..347959) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /label="yckA gene" downshifts complement(347285) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(347969..348832) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" /label="yckB CDS" gene complement(347969..348832) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /label="yckB gene" promotor_-10 complement(348854..348873) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(348866) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(348868..351702) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(348888..348895) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 348905..348911 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 348926..348944 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 348938..349160 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 348938 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 348994..349191 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" /label="hypothetical protein CDS" gene 348994..349191 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /label="gene" promotor_-35 349129..349134 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 349150..349168 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 349162 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 349210..349665 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" /label="yckC CDS" gene 349210..349665 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /label="yckC gene" downshifts 349640 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 349688..349694 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 349701 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 349708..349719 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 349747..350079 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" /label="yckD CDS" gene 349747..350079 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /label="yckD gene" downshifts 350060 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 350165..350172 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350188..350207 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 350192 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="upshifts" CDS 350233..351666 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" /label="bglC CDS" gene 350233..351666 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /label="bglC gene" downshifts 351644 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(351703..352101) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" /label="nin CDS" gene complement(351703..352101) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /label="nin gene" promotor_no_box complement(352098..352198) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(352128..352577) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" /label="nucA CDS" gene complement(352128..352577) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /label="nucA gene" upshifts complement(352138) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(352592..352611) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(352600) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(352602..352744) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(352625..352632) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(352745..354466) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" /label="tlpC CDS" gene complement(352745..354466) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /label="tlpC gene" promotor_-35 352757..352764 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 352775..355918 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 352775 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 352779..352798 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(352780..352880) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(352820) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="upshifts" promotor_-10 complement(354490..354508) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(354505) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="upshifts" promotor_-35 complement(354522..354529) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(354577..355134) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" /label="hxlB CDS" gene complement(354577..355134) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /label="hxlB gene" downshifts complement(354580) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(355140..355772) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" /label="hxlA CDS" gene complement(355140..355772) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /label="hxlA gene" promotor_-10 complement(355798..355817) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(355813) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(355832..355835) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 355896..355899 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 355914..355933 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 355920 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="upshifts" CDS 356006..356368 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" /label="hxlR CDS" gene 356006..356368 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /label="hxlR gene" downshifts 356352 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 356615..356618 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 356633..356652 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 356641..356941 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 356641 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="upshifts" CDS 356942..367705 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" /label="srfAA CDS" gene 356942..367705 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /label="srfAA gene" CDS 367718..378469 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" /label="srfAB CDS" gene 367718..378469 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /label="srfAB gene" CDS 370854..370994 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 370854..370994 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" CDS 378506..382333 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" /label="srfAC CDS" gene 378506..382333 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /label="srfAC gene" CDS 382362..383090 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" /label="srfAD CDS" gene 382362..383090 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /label="srfAD gene" downshifts 383072 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" /label="downshifts" promotor_-35 383128..383135 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 383138 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 383147..383166 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 383191..384417 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" /label="srfT CDS" gene 383191..384417 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /label="srfT gene" downshifts 384411 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(384432..384989) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" /label="ycxB CDS" gene complement(384432..384989) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /label="ycxB gene" promotor_no_box complement(384447..384547) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(384469) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" /label="downshifts" upshifts complement(384487) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(385018..385037) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(385020) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(385043..385981) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" /label="ycxC CDS" gene complement(385043..385981) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /label="ycxC gene" promotor_-10 complement(386020..386038) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(386027) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(386054..386059) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 386105..387439 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" /label="ycxD CDS" gene 386105..387439 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /label="ycxD gene" CDS complement(387434..387601) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" /label="sfpAc CDS" gene complement(387434..387601) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo /label="sfpAc gene" CDS complement(387612..388109) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" /label="sfpAn CDS" gene complement(387612..388109) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo /label="sfpAn gene" misc_feature complement(388136..388155) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(388148) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" CDS complement(388214..388861) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" /label="yczE CDS" gene complement(388214..388861) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /label="yczE gene" promotor_-10 complement(388890..388909) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(388893) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(388925..388929) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(389030..389181) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(389182..389925) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" /label="tcyC CDS" gene complement(389182..389925) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /label="tcyC gene" downshifts complement(389238) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(389939..390643) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" /label="tcyB CDS" gene complement(389939..390643) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /label="tcyB gene" CDS complement(390630..391436) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" /label="tcyA CDS" gene complement(390630..391436) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /label="tcyA gene" promotor_-10 complement(391485..391504) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(391497) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(391518..391525) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(391552..392424) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" /label="bsdA CDS" gene complement(391552..392424) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /label="bsdA gene" promotor_-10 complement(392162..392180) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(392169) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(392195..392201) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 392478..392485 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(392493..392512) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 392499..392518 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(392499) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="upshifts" upshifts 392507 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="upshifts" CDS 392514..393128 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" /label="ubiX CDS" gene 392514..393128 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /label="ubiX gene" promotor_-35 complement(392526..392533) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 393131..394552 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" /label="bsdC CDS" gene 393131..394552 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /label="bsdC gene" CDS 394569..394796 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" /label="bsdD CDS" gene 394569..394796 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /label="bsdD gene" CDS 394793..395257 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" /label="yclD CDS" gene 394793..395257 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /label="yclD gene" downshifts 395238 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 395264..395265 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 395265 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 395324..396169 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" /label="yclE CDS" gene 395324..396169 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /label="yclE gene" CDS complement(396209..397687) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" /label="dtpT CDS" gene complement(396209..397687) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /label="dtpT gene" downshifts complement(396217) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 397714..397716 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(397715..397734) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 397725 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 397733..397751 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(397735) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(397737..>397920) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(397749..397756) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 397905..397914 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 397920..397921 /note_="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_011" downshifts 397926 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(397936..399375) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" /label="gabR CDS" gene complement(397936..399375) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /label="gabR gene" promotor_-10 complement(398260..398271) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(398266) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(398285..398291) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(399418..399437) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 399419..399426 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(399425) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 399440..399459 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399444 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(399448..399455) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 399482..400792 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" /label="gabT CDS" gene 399482..400792 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /label="gabT gene" promotor_-35 400670..400676 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 400690..400708 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 400698 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 400794..400801 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 400816..400835 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 400825 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" CDS 400861..402249 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" /label="gabD CDS" gene 400861..402249 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /label="gabD gene" downshifts 402257 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 402307..402313 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 402327..402338 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 402328 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="upshifts" CDS 402372..403235 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" /label="glcU CDS" gene 402372..403235 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /label="glcU gene" CDS 403255..404040 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" /label="gdh CDS" gene 403255..404040 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /label="gdh gene" misc_feature 403360..403379 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 403360 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 403448 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" /label="downshifts" downshifts 404042 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" /label="downshifts" CDS complement(404085..404699) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" /label="cutI CDS" gene complement(404085..404699) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /label="cutI gene" downshifts complement(404096) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(404712..406337) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" /label="cutJ CDS" gene complement(404712..406337) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /label="cutJ gene" CDS complement(406372..406944) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" /label="cutR CDS" gene complement(406372..406944) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /label="cutR gene" promotor_-10 complement(406966..406985) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(406981) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(406999..407006) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 407066..407085 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 407078 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="upshifts" CDS 407109..407462 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" /label="ycnL CDS" gene 407109..407462 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /label="ycnL gene" downshifts 407433 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 407526..407533 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 407547..407566 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 407552 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" S_feature 407562..407634 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 407635..409071 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" /label="mtlA CDS" gene 407635..409071 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /label="mtlA gene" CDS 409096..409527 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" /label="mtlF CDS" gene 409096..409527 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /label="mtlF gene" CDS 409529..410650 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" /label="mtlD CDS" gene 409529..410650 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /label="mtlD gene" downshifts 410633 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-35 410679..410682 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 410698..410717 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 410700 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="upshifts" CDS 410741..411805 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" /label="ycsA CDS" gene 410741..411805 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /label="ycsA gene" promotor_-35 410975..410983 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 410997..411016 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411007 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 411799 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 411872..411879 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 411892..411911 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411905 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 411940..412503 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" /label="sipU CDS" gene 411940..412503 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /label="sipU gene" S_feature 412504..413228 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(412563..413171) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" /label="yczH CDS" gene complement(412563..413171) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /label="yczH gene" misc_feature complement(413189..413208) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 413205..413211 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(413212) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 413224..413243 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413230 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 413257..413649 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" /label="ycsD CDS" gene 413257..413649 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /label="ycsD gene" downshifts 413626 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(413682..413846) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" /label="yczO CDS" gene complement(413682..413846) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /label="yczO gene" downshifts complement(413702) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(413856..413874) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(413878) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(413889..413895) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 413908..413915 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413929..413948 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413932 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="upshifts" CDS 413979..414728 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" /label="ribZ CDS" gene 413979..414728 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /label="ribZ gene" downshifts 414705 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(414781) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" promotor_-35 414811..414817 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 414831..414850 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 414837..414933 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 414837 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 414934..415707 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" /label="pxpA CDS" gene 414934..415707 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /label="pxpA gene" CDS 415722..416936 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" /label="pxpG CDS" gene 415722..416936 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /label="pxpG gene" CDS 416960..417733 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" /label="pxpI CDS" gene 416960..417733 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /label="pxpI gene" CDS 417778..418500 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" /label="pxpB CDS" gene 417778..418500 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /label="pxpB gene" CDS 418503..419510 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" /label="pxpC CDS" gene 418503..419510 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /label="pxpC gene" downshifts 418996 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" /label="downshifts" promotor_no_box 419090..419190 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 419150 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 419526..420278 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" /label="pxpR CDS" gene 419526..420278 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /label="pxpR gene" promotor_-35 420276..420285 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 420299..420318 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 420309 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 420342..420983 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" /label="lipC CDS" gene 420342..420983 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /label="lipC gene" downshifts 420969 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(420981..421406) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(421026) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 421059..421065 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421079..421098 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421080 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="upshifts" CDS 421156..421401 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" /label="yczI CDS" gene 421156..421401 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /label="yczI gene" S_feature 421402..421812 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(421407..421694) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" /label="yczJ CDS" gene complement(421407..421694) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /label="yczJ gene" misc_feature complement(421715..421734) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(421731) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 421788..421792 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421809..421828 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421814 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 421845..423851 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" /label="pbpC CDS" gene 421845..423851 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /label="pbpC gene" S_feature 423852..423952 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 423953..424855 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" /label="ycsN CDS" gene 423953..424855 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /label="ycsN gene" downshifts 424835 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 424928..424935 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424949..424968 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 424953..425040 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 424953 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 425041..427125 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" /label="mtlR CDS" gene 425041..427125 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /label="mtlR gene" downshifts 427112 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 427154..427160 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 427174..427192 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 427186 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="upshifts" S_feature 427197..427278 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 427240..427247 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 427261..427280 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 427280 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="upshifts" CDS 427337..428848 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" /label="ydaB CDS" gene 427337..428848 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /label="ydaB gene" downshifts 428832 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" /label="downshifts" CDS complement(428868..429413) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" /label="ydaC CDS" gene complement(428868..429413) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /label="ydaC gene" downshifts complement(428901) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(429480..429498) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(429494) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(429513..429519) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 429555..429561 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 429573 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="upshifts" promotor_-10 429576..429594 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 429620..430480 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" /label="ydaD CDS" gene 429620..430480 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /label="ydaD gene" CDS 430496..430999 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" /label="lyxE CDS" gene 430496..430999 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /label="lyxE gene" downshifts 430980 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" /label="downshifts" promotor_-35 431028..431035 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431049..431068 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431051 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 431085..431636 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" /label="ydaF CDS" gene 431085..431636 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /label="ydaF gene" promotor_-35 431651..431657 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431672..431690 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431685 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 431714..432136 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" /label="ydaG CDS" gene 431714..432136 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /label="ydaG gene" promotor_-35 432141..432149 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 432160..432179 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 432179..432545 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 432179 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(432205..432305) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(432240..432508) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" /label="bsrC RNA" gene complement(432240..432508) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /label="bsrC gene" upshifts complement(432245) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 432502 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 432582..432591 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 432604..432619 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 432609 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 432642..433451 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" /label="amj CDS" gene 432642..433451 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /label="amj gene" downshifts 433432 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" /label="downshifts" CDS complement(433495..433785) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" /label="ydzA CDS" gene complement(433495..433785) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /label="ydzA gene" downshifts complement(433499) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(433813..433832) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 433813..433831 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 433819 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(433829) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 433907..433914 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 433928..433947 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 433932 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 433970..434404 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" /label="lrpC CDS" gene 433970..434404 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /label="lrpC gene" promotor_-35 434401..434404 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 434413 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 434421..434440 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 434469..436652 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" /label="topB CDS" gene 434469..436652 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /label="topB gene" downshifts 436635 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 436701..436707 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 436722..436740 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 436723..436854 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 436723 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="upshifts" CDS 436855..437943 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" /label="epsJ CDS" gene 436855..437943 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /label="epsJ gene" CDS 437924..438775 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" /label="epsK CDS" gene 437924..438775 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /label="epsK gene" CDS 438786..440495 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" /label="ydaL CDS" gene 438786..440495 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /label="ydaL gene" CDS 440488..441750 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" /label="ydaM CDS" gene 440488..441750 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /label="ydaM gene" CDS 441756..443867 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" /label="ydaN CDS" gene 441756..443867 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /label="ydaN gene" downshifts 443851 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" /label="downshifts" promotor_-35 443964..443971 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 443986..444005 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 443993 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 444003..444146 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" /label="swaO RNA" gene 444003..444146 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /label="swaO gene" downshifts 444144 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" /label="downshifts" S_feature 444189..444342 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 444343..446166 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" /label="kimA CDS" gene 444343..446166 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /label="kimA gene" downshifts 446158 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" /label="downshifts" CDS 446225..446674 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" /label="nudT CDS" gene 446225..446674 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /label="nudT gene" promotor_-35 446687..446693 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 446708..446726 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 446709 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="upshifts" CDS 446741..448465 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" /label="poxB CDS" gene 446741..448465 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /label="poxB gene" S_feature complement(447577..448436) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(448438..448549) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 448449 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(448457..448660) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" /label="hypothetical protein CDS" gene complement(448457..448660) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /label="gene" downshifts complement(448481) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(448509..448609) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 448518..448523 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 448540..448558 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(448549) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature 448550..448765 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 448550 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(448616..448687) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(448659) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(448688..448954) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" /label="ydzK CDS" gene complement(448688..448954) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /label="ydzK gene" promotor_-10 complement(448970..448989) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(448988) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(449001..449008) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(449058..450335) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" /label="mntH CDS" gene complement(449058..450335) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /label="mntH gene" downshifts complement(449077) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(450397..450416) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(450409) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(450411..450488) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(450429..450436) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(450472..450491) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(450488) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(450505..450514) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(450565..450822) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" /label="ydaS CDS" gene complement(450565..450822) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /label="ydaS gene" downshifts complement(450573) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" downshifts complement(450639) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS complement(450900..451352) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" /label="ydaT CDS" gene complement(450900..451352) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /label="ydaT gene" promotor_-10 complement(451371..451389) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(451388) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(451403..451409) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 451421 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 451429..451448 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 451470..452288 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" /label="ydbA CDS" gene 451470..452288 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /label="ydbA gene" downshifts 452279 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 452356..452362 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 452376..452394 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 452384 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="upshifts" CDS 452417..452788 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" /label="gsiB CDS" gene 452417..452788 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /label="gsiB gene" downshifts complement(452421) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 452805 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" upshifts complement(452839) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(452842..452845) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 452867..452874 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 452886..452905 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 452893 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="upshifts" CDS 452920..453261 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" /label="ydbB CDS" gene 452920..453261 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /label="ydbB gene" CDS 453255..453614 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" /label="ydbC CDS" gene 453255..453614 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /label="ydbC gene" S_feature complement(453317..453610) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 453555 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 453599 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(453651..454472) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" /label="ydbD CDS" gene complement(453651..454472) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /label="ydbD gene" downshifts complement(453655) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(454494..454512) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(454515) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(454526..454532) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(454557..455609) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" /label="dctB CDS" gene complement(454557..455609) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /label="dctB gene" promotor_-35 454869..454876 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 454891..455678 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 454891..454910 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 454892 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(455622..455641) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(455627) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(455655..455662) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 455679..457286 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" /label="dctS CDS" gene 455679..457286 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /label="dctS gene" CDS 457276..457956 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" /label="dctR CDS" gene 457276..457956 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /label="dctR gene" S_feature 457957..458031 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 457998..458005 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 458020..458037 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 458033 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="upshifts" CDS 458077..459342 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" /label="dctP CDS" gene 458077..459342 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /label="dctP gene" downshifts 459335 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(459389) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" /label="downshifts" misc_feature 459426..459443 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 459428 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 459490..460542 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" /label="ydbI CDS" gene 459490..460542 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /label="ydbI gene" S_feature 460543..460786 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 460743 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" CDS 460819..461745 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" /label="ydbJ CDS" gene 460819..461745 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /label="ydbJ gene" CDS 461765..462505 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" /label="ydbK CDS" gene 461765..462505 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /label="ydbK gene" misc_feature 462564..462583 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 462569 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 462600..462935 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" /label="ydbL CDS" gene 462600..462935 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /label="ydbL gene" downshifts 462910 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" /label="downshifts" S_feature 462955..463024 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 462990..462997 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 463011..463030 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 463025 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 463063..464208 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" /label="ydbM CDS" gene 463063..464208 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /label="ydbM gene" downshifts 464190 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(464233..464412) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" /label="fbpB CDS" gene complement(464233..464412) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /label="fbpB gene" downshifts complement(464251) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(464366..464530) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" /label="fbpA CDS" gene complement(464366..464530) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /label="fbpA gene" S_feature complement(464413..464581) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(464573..464592) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(464583) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(464607..464614) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 464722..464727 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 464743..464761 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 464747 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="upshifts" CDS 464777..465649 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" /label="ydbO CDS" gene 464777..465649 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /label="ydbO gene" promotor_-35 465013..465022 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 465035..465050 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 465038 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(465594..465663) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(465637) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 465650..465999 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(465664..465984) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" /label="ydbP CDS" gene complement(465664..465984) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /label="ydbP gene" promotor_-35 465980..465984 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 465993..466007 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 466001..466158 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 466001 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(466005..466024) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(466020) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(466038..466045) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 466159..467223 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" /label="ddlA CDS" gene 466159..467223 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /label="ddlA gene" downshifts 467211 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS 467295..468668 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" /label="murF CDS" gene 467295..468668 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /label="murF gene" promotor_-35 468699..468705 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 468719..468730 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 468729 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 468772..468791 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 468773..468947 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 468773 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 468915..468922 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 468937..468956 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 468949..469016 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 468949 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="upshifts" CDS 469068..470552 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" /label="cshA CDS" gene 469068..470552 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /label="cshA gene" downshifts 470545 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" S_feature 470665..470724 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 470665..470674 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 470667 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 470686..470701 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 470725..471204 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " /label="ydbS CDS" gene 470725..471204 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /label="ydbS gene" CDS 471194..472675 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" /label="ydbT CDS" gene 471194..472675 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /label="ydbT gene" downshifts 472645 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature 472690..473017 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(472699) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" /label="downshifts" CDS complement(472927..473526) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" /label="ydcA CDS" gene complement(472927..473526) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /label="ydcA gene" promotor_-35 472987..472992 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 473005..473024 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 473019..473620 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 473019 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(473550..473569) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(473561) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="upshifts" CDS 473621..473986 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" /label="acpS CDS" gene 473621..473986 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /label="acpS gene" promotor_-35 473989..473994 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 474010..474151 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 474010..474028 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 474010 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="upshifts" CDS 474152..475168 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" /label="ydcC CDS" gene 474152..475168 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /label="ydcC gene" downshifts 475153 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 475213..475220 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 475234..475253 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 475241 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 475283..476452 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" /label="alrA CDS" gene 475283..476452 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /label="alrA gene" promotor_-35 476381..476386 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476401..476419 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476407 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 476482..476485 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476501..476520 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476502 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 476568..476849 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" /label="ndoAI CDS" gene 476568..476849 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /label="ndoAI gene" CDS 476854..477204 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" /label="ndoA CDS" gene 476854..477204 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /label="ndoA gene" S_feature complement(476994..477470) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(477037) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts 477184 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" /label="downshifts" promotor_-35 477238..477245 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 477259..477278 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 477267 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 477319..478143 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" /label="rsbRA CDS" gene 477319..478143 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /label="rsbRA gene" promotor_-10 complement(477453..477471) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(477470) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(477472..478071) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(477485..477492) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(478060..478078) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478071) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(478073..478661) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(478092..478098) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 478148..478513 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" /label="rsbS CDS" gene 478148..478513 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /label="rsbS gene" CDS 478517..478918 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" /label="rsbT CDS" gene 478517..478918 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /label="rsbT gene" promotor_-10 complement(478659..478678) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478676) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(478692..478701) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 478930..479937 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" /label="rsbU CDS" gene 478930..479937 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /label="rsbU gene" promotor_-35 479931..479937 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 479952..479970 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 479958 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 479999..480328 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" /label="rsbV CDS" gene 479999..480328 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /label="rsbV gene" CDS 480325..480807 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" /label="rsbW CDS" gene 480325..480807 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /label="rsbW gene" CDS 480773..481561 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" /label="sigB CDS" gene 480773..481561 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /label="sigB gene" CDS 481561..482160 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" /label="rsbX CDS" gene 481561..482160 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /label="rsbX gene" downshifts 482146 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 482204..482210 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 482225..482244 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" Polymorphism join(482233,482235) /Source="geneious" /ID="SNP_BsDelta6_524323_524323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="A -> C" /Codon_Change /Coverage=183 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="BSU_04745_promoter_down_mutation" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 482237 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 482271..482387 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" /label="hypothetical protein CDS" gene 482271..482387 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /label="gene" CDS 482403..482696 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" /label="ydcF CDS" gene 482403..482696 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /label="ydcF gene" promotor_-35 482664..482672 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 482684..482703 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 482693..483133 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" /label="ydcG CDS" gene 482693..483133 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /label="ydcG gene" upshifts 482699 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(482932..485987) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 483117..483560 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" /label="ydcH CDS" gene 483117..483560 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /label="ydcH gene" downshifts 483535 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 483591..483592 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 483608..483627 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 483608 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="upshifts" CDS 483654..485813 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" /label="tex CDS" gene 483654..485813 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /label="tex gene" misc_feature 485801..485820 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 485823..486039 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 485823 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="upshifts" CDS complement(485823..485936) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" /label="cmpA CDS" gene complement(485823..485936) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /label="cmpA gene" promotor_-10 complement(485976..485995) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(485993) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(486010..486018) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 486040..486492 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" /label="ydcK CDS" gene 486040..486492 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /label="ydcK gene" promotor_-35 486498..486504 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 486519..486538 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 486527..486614 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 486527 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(486559) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" /label="downshifts" tRNA 486615..486689 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Asn tRNA" gene 486615..486689 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /label="trnS-Asn gene" tRNA 486694..486784 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Ser tRNA" gene 486694..486784 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /label="trnS-Ser gene" tRNA 486814..486885 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Glu tRNA" gene 486814..486885 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /label="trnS-Glu gene" tRNA 486897..486971 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Gln tRNA" gene 486897..486971 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /label="trnS-Gln gene" tRNA 486998..487073 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Lys tRNA" gene 486998..487073 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /label="trnS-Lys gene" tRNA 487085..487166 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu1 tRNA" gene 487085..487166 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /label="trnS-Leu1 gene" downshifts 487231 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA 487247..>487332 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu2 tRNA" gene 487247..>487332 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /modified_by="User" /label="trnS-Leu2 gene" SCAR 487332..487333 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="Delta6_2" S_feature complement(<487333..487639) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /modified_by="User" /label="S175" downshifts 487352 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" /label="downshifts" downshifts complement(487384) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(487640..488659) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" /label="yddN CDS" gene complement(487640..488659) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /label="yddN gene" promotor_-10 complement(488335..488354) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(488348) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(488369..488376) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 488448..488452 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488469..488488 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488473 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="upshifts" S_feature 488474..488918 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 488919..489329 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" /label="lrpA CDS" gene 488919..489329 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /label="lrpA gene" S_feature 489330..489399 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 489356 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" /label="downshifts" CDS complement(489452..489901) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" /label="lrpB CDS" gene complement(489452..489901) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /label="lrpB gene" CDS 490016..490558 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" /label="yddQ CDS" gene 490016..490558 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /label="yddQ gene" promotor_-35 491031..491035 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 491052..491071 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 491061 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="upshifts" CDS 491111..491875 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" /label="yddR CDS" gene 491111..491875 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /label="yddR gene" CDS 492069..493379 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" /label="yddS CDS" gene 492069..493379 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /label="yddS gene" S_feature 493402..493961 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 493962..494138 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" /label="ydzM CDS" gene 493962..494138 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /label="ydzM gene" CDS 494163..494849 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" /label="yddT CDS" gene 494163..494849 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /label="yddT gene" promotor_-35 495191..495195 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 495210..495229 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 495218 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="upshifts" Polymorphism join(495265,495267) /Source="geneious" /ID="SNP_BsDelta6_557866_557865" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)5 -> (T)6" /Codon_Change /Coverage=35 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value="3.2e-123" /Variant_Raw_Frequency=35 /comment="ydzN_translation_signal_variant" /modified_by="User" / /label="Polymorphism_Delta6" CDS 495274..495459 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" /label="ydzN CDS" gene 495274..495459 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /label="ydzN gene" downshifts 495458 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" /label="downshifts" CDS 495809..496402 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" /label="sufLC CDS" gene 495809..496402 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /label="sufLC gene" promotor_-35 496515..496522 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 496536..496555 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 496547..496664 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 496547 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(496582) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" /label="downshifts" CDS 496665..496865 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" /label="cspC CDS" gene 496665..496865 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /label="cspC gene" S_feature complement(496763..497551) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 496768 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 496869 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" /label="downshifts" misc_RNA complement(496933..497011) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sncZ RNA" gene complement(496933..497011) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /label="sncZ gene" CDS complement(497552..498013) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" /label="cdnL CDS" gene complement(497552..498013) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /label="cdnL gene" S_feature 498022..498567 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(498065) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(498072..498091) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(498107..498114) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 498534 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" /label="downshifts" CDS complement(498581..498817) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" /label="ydzE CDS" gene complement(498581..498817) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /label="ydzE gene" CDS complement(498915..499790) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" /label="ydeC CDS" gene complement(498915..499790) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /label="ydeC gene" CDS 499903..500862 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" /label="ydeD CDS" gene 499903..500862 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /label="ydeD gene" upshifts complement(499924) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(499928..499947) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(501015..501887) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" /label="ydeE CDS" gene complement(501015..501887) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /label="ydeE gene" promotor_-10 complement(501980..501985) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(501987..501988) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(501992) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 502061..502067 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 502075 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 502081..502100 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 502114..503502 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" /label="ydeF CDS" gene 502114..503502 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /label="ydeF gene" downshifts 503478 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS 503612..504904 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" /label="ydeG CDS" gene 503612..504904 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /label="ydeG gene" promotor_-35 504913..504919 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 504934..504953 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 504941 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="upshifts" S_feature 504952..505062 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 505063..505509 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" /label="ydeH CDS" gene 505063..505509 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /label="ydeH gene" downshifts 505538 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 505589..505596 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 505611..505630 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 505612 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="upshifts" CDS 505746..506339 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" /label="ydeI CDS" gene 505746..506339 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /label="ydeI gene" downshifts 506382 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(506458) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 506471..506478 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 506492 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 506493..506512 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(506691..507350) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" /label="ydeJ CDS" gene complement(506691..507350) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /label="ydeJ gene" promotor_-10 complement(507399..507418) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(507406) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(507430..507435) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(507772..508635) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" /label="ydeK CDS" gene complement(507772..508635) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /label="ydeK gene" promotor_-35 508678..508684 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 508699..508718 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(508700..508719) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 508714 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(508724) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(508734..508741) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 508790..510181 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" /label="ydeL CDS" gene 508790..510181 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /label="ydeL gene" promotor_-35 510309..510316 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 510327..510346 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 510341 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="upshifts" CDS 510375..510800 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" /label="ydeM CDS" gene 510375..510800 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /label="ydeM gene" S_feature 510801..512055 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(510853..511425) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" /label="ydeN CDS" gene complement(510853..511425) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /label="ydeN gene" downshifts complement(510858) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(511426..511506) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(511507..511836) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" /label="ydzF CDS" gene complement(511507..511836) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /label="ydzF gene" misc_feature complement(511853..511872) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(511870) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="upshifts" misc_feature 512044..512063 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 512057 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="upshifts" CDS 512091..512963 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" /label="ydeO CDS" gene 512091..512963 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /label="ydeO gene" downshifts 512850 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 513048 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(513113..513499) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" /label="ydeP CDS" gene complement(513113..513499) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /label="ydeP gene" downshifts complement(513125) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(513500..513564) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 513552..513559 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(513553..513572) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(513566) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 513573..513592 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 513576 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(513587..513594) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 513610..514203 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" /label="ydeQ CDS" gene 513610..514203 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /label="ydeQ gene" CDS complement(514347..515534) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" /label="ydeR CDS" gene complement(514347..515534) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /label="ydeR gene" promotor_-35 515670..515674 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 515688 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 515689..515708 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 515738..516334 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" /label="ydeS CDS" gene 515738..516334 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /label="ydeS gene" CDS 516448..516633 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" /label="ydzO CDS" gene 516448..516633 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /label="ydzO gene" downshifts 516612 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 516745..516748 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 516755..516941 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 516755 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 516763..516782 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 516942..517277 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" /label="aseR CDS" gene 516942..517277 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /label="aseR gene" CDS 517290..518597 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" /label="arsF CDS" gene 517290..518597 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /label="arsF gene" CDS 518629..518733 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" /label="ydzSn CDS" gene 518629..518733 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo /label="ydzSn gene" CDS 518742..518855 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" /label="ydzSc CDS" gene 518742..518855 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo /label="ydzSc gene" promotor_-35 519041..519049 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 519060..519078 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 519077 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 519095..519880 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" /label="ydfB CDS" gene 519095..519880 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /label="ydfB gene" downshifts 519142 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 519890 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS complement(519937..520857) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" /label="ydfC CDS" gene complement(519937..520857) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /label="ydfC gene" CDS 520990..522438 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" /label="ydfD CDS" gene 520990..522438 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /label="ydfD gene" CDS complement(522556..523179) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" /label="ydfE CDS" gene complement(522556..523179) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /label="ydfE gene" promotor_-10 complement(523203..523222) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 523211..523218 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(523222) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 523233..523252 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 523235 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(523237..523243) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 523269..523949 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" /label="ydfF CDS" gene 523269..523949 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /label="ydfF gene" downshifts 523982 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(524029..524472) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" /label="ydfG CDS" gene complement(524029..524472) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /label="ydfG gene" downshifts complement(524034) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(524495..524514) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(524519) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(524528..524535) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(524558..524737) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" /label="ydzP CDS" gene complement(524558..524737) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /label="ydzP gene" CDS complement(524734..524877) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" /label="ydzQ CDS" gene complement(524734..524877) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /label="ydzQ gene" promotor_-35 524828..524830 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 524846..524865 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 524862 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 525145..526368 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" /label="ydfH CDS" gene 525145..526368 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /label="ydfH gene" CDS 526361..527002 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" /label="ydfI CDS" gene 526361..527002 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /label="ydfI gene" downshifts 526996 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(527029..527048) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(527050) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(527062..527069) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 527110..527115 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 527118..529292 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" /label="ydfJ CDS" gene 527118..529292 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /label="ydfJ gene" upshifts 527128 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 527130..527148 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(528194..528212) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(528194) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(529296..529703) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 529313..529317 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 529327 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 529330..529349 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(529341) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(529704..530606) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" /label="cesA CDS" gene complement(529704..530606) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /label="cesA gene" S_feature complement(530607..530702) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(530682..530701) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(530702) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(530715..530722) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(530808..531497) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" /label="ydfK CDS" gene complement(530808..531497) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /label="ydfK gene" CDS complement(531587..532399) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" /label="ydfL CDS" gene complement(531587..532399) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /label="ydfL gene" promotor_-10 complement(532428..532447) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(532441) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(532463..532470) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(532510..533403) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" /label="mneP CDS" gene complement(532510..533403) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /label="mneP gene" downshifts complement(532530) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(533404..533496) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(533477..533496) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(533494) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(533512..533519) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 533685..533692 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 533707..533726 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 533713 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 533879..534499 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" /label="ydfN CDS" gene 533879..534499 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /label="ydfN gene" promotor_-35 534223..534229 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 534234 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 534243..534261 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 534515..535453 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" /label="ydfO CDS" gene 534515..535453 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /label="ydfO gene" promotor_-35 535441..535444 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 535459..535478 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 535466..535554 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 535466 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 535555..535944 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" /label="ydfP CDS" gene 535555..535944 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /label="ydfP gene" downshifts 535935 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" /label="downshifts" misc_feature 536058..536077 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 536060..536129 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 536060 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 536130..536468 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" /label="ydfQ CDS" gene 536130..536468 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /label="ydfQ gene" downshifts 536456 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(536508..536744) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" /label="ydzH CDS" gene complement(536508..536744) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /label="ydzH gene" downshifts complement(536532) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 536556..536562 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 536577..536588 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 536588 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(536745..536906) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(536910..537275) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(536950) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(537276..537506) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" /label="ydzR CDS" gene complement(537276..537506) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /label="ydzR gene" downshifts 537490 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(537527..537546) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(537544) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(537546..537629) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(537560..537569) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(537630..538307) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" /label="ydfR CDS" gene complement(537630..538307) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /label="ydfR gene" promotor_-10 complement(538278..538289) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(538292) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(538304..538310) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(538308..539141) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 538323..538328 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 538343..538354 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 538348 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="upshifts" CDS 538420..539127 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" /label="ydfS CDS" gene 538420..539127 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /label="ydfS gene" CDS complement(539142..539573) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" /label="cotP CDS" gene complement(539142..539573) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /label="cotP gene" CDS complement(539586..539828) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" /label="ydgA CDS" gene complement(539586..539828) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /label="ydgA gene" CDS complement(539842..540114) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" /label="ydgB CDS" gene complement(539842..540114) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /label="ydgB gene" promotor_-10 complement(540136..540155) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(540140) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(540169..540178) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 540333..540340 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 540356..540375 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 540364 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="upshifts" CDS 540413..541000 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" /label="ydgC CDS" gene 540413..541000 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /label="ydgC gene" CDS 540997..541341 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" /label="ydgD CDS" gene 540997..541341 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /label="ydgD gene" S_feature 541342..541503 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 541504..541977 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" /label="ydgE CDS" gene 541504..541977 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /label="ydgE gene" S_feature 541978..542670 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(542120) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(542137..543780) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" /label="vmlR CDS" gene complement(542137..543780) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /label="vmlR gene" S_feature complement(543815..544012) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 543829..543831 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 543848..543866 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 543852 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(543858) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 543978 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(544004..544023) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(544016) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(544036..544043) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(544099) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(544100..545476) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" /label="ydgF CDS" gene complement(544100..545476) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /label="ydgF gene" misc_feature complement(545526..545545) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(545541) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="upshifts" Polymorphism join(545615,545617) /Source="geneious" /ID="SNP_BsDelta6_608215_608214" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)5 -> (A)6" /Codon_Change /Coverage=41 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="8.2e-115" /Variant_Raw_Frequency=39 /comment="dinB_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" terminator 545616..545649 /created_by="User" /comment="dinB_terminator_improvement" /modified_by="User" /label="Delta6_dinB_Terminator" CDS complement(545648..546166) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" /label="dinB CDS" gene complement(545648..546166) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /label="dinB gene" downshifts complement(545662) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(546192..546211) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(546211) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(546227..546230) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 546248..546255 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 546270..546289 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 546288 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="upshifts" CDS complement(546300..546701) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /locus_tag="BSU_05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /modified_by="User" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_BSU_05890_3'_ext" CDS complement(546300..546428) /locus_tag="PG10_rand_002" /created_by="User" /transl_table=11 /pseudo /translation="MYNHGNLITDLLDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_rand_002" gene complement(546300..546701) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /old_locus_tag="BSU_05890" /pseudo /modified_by="User" /label="PG10_BSU_05890_3'_ext" gene complement(546300..546428) /locus_tag="PG10_rand_002" /created_by="User" /label="PG10_rand_002" CDS 546318..546410 /locus_tag="PG10_rand_001" /created_by="User" /transl_table=11 /pseudo /translation="MRLIRAHFINSCFLQHTCRLKKQVIQQVSN*" /label="PG10_rand_001" gene 546318..546410 /locus_tag="PG10_rand_001" /created_by="User" /modified_by="User" /label="PG10_rand_001" SCAR 546320..546321 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs22" CDS complement(546632..546826) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" /label="ydhUn CDS" gene complement(546632..546826) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo /label="ydhUn gene" promotor_-10 complement(546859..546870) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(546867) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(546884..546890) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 546945..546952 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 546966..546985 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 546968..547068 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 546970 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(547016) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" upshifts 547028 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 547036..547043 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 547057..547076 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 547072..547159 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 547072 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" tRNA 547160..547236 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Arg tRNA" gene 547160..547236 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /label="trnE-Arg gene" tRNA 547250..547323 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Gly tRNA" gene 547250..547323 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /label="trnE-Gly gene" rRNA 547483..549037 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-16S rRNA" gene 547483..549037 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /label="rrnE-16S gene" rRNA 549205..552132 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-23S rRNA" gene 549205..552132 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /label="rrnE-23S gene" rRNA 552188..552304 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-5S rRNA" gene 552188..552304 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /label="rrnE-5S gene" tRNA 552318..552394 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Met tRNA" gene 552318..552394 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /label="trnE-Met gene" tRNA 552455..552531 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Asp tRNA" gene 552455..552531 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /label="trnE-Asp gene" downshifts 552528 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" /label="downshifts" promotor_-35 552632..552636 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 552652..552671 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 552656 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="upshifts" CDS 552712..553689 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" /label="thiL CDS" gene 552712..553689 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /label="thiL gene" CDS 553704..554180 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" /label="tsaE CDS" gene 553704..554180 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /label="tsaE gene" CDS 554161..554850 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" /label="tsaB CDS" gene 554161..554850 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /label="tsaB gene" CDS 554860..555315 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" /label="rimI CDS" gene 554860..555315 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /label="rimI gene" CDS 555308..556348 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" /label="tsaD CDS" gene 555308..556348 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /label="tsaD gene" downshifts 556312 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(556578..558506) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" /label="ydiF CDS" gene complement(556578..558506) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /label="ydiF gene" downshifts complement(556595) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" misc_feature 558258..558277 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 558268 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" S_feature 558270..558459 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 558424..558431 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 558445..558464 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 558461..558631 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 558461 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(558526..558545) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(558538) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(558559..558566) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 558632..559144 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" /label="moaC CDS" gene 558632..559144 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /label="moaC gene" CDS 559141..559788 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" /label="rex CDS" gene 559141..559788 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /label="rex gene" promotor_no_box 559618..559718 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 559678 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" CDS 559810..559983 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" /label="tatAY CDS" gene 559810..559983 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /label="tatAY gene" CDS 559990..560754 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" /label="tatCY CDS" gene 559990..560754 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /label="tatCY gene" downshifts 560734 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560792..560983) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" /label="ydiK CDS" gene complement(560792..560983) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /label="ydiK gene" downshifts complement(560809) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(560980..561714) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" /label="ydiL CDS" gene complement(560980..561714) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /label="ydiL gene" promotor_-35 561372..561377 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 561392..561410 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 561394 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 561713..561714 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 561724..561738 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 561746 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="upshifts" promotor_-10 complement(561751..561770) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 561768..561876 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(561771) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(561784..561789) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 561850..561856 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 561870..561889 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 561878..561952 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 561878 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="upshifts" CDS 561953..562237 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" /label="groES CDS" gene 561953..562237 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /label="groES gene" CDS 562284..563918 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" /label="groEL CDS" gene 562284..563918 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /label="groEL gene" S_feature 563919..564011 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 563968 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" /label="downshifts" CDS complement(564006..564134) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" /label="ydzTc CDS" gene complement(564006..564134) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo /label="ydzTc gene" S_feature 564013..>565239 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(564137..564295) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" /label="ydzT CDS" gene complement(564137..564295) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo /label="ydzT gene" CDS complement(564340..564468) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" /label="ydzT CDS" gene complement(564340..564468) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo /label="ydzT gene" CDS complement(564561..564770) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" /label="ydzT CDS" gene complement(564561..564770) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo /label="ydzT gene" CDS complement(564763..565068) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " /label="ydzTn CDS" gene complement(564763..565068) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo /label="ydzTn gene" SCAR join(565239,565246) /created_by="AR/SM" /note="deletion occured in betwen marked nucleotides" /label="Delta6_1" N_region 565240..565245 /note="KpnI site (GGTACC)" /created_by="User" /label="Delta6_1" CDS complement(565344..567833) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" /label="gutR CDS" gene complement(565344..567833) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /label="gutR gene" downshifts complement(565366) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(567847..567866) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(567873) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(567880..567887) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 567936..567937 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 567952..568034 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 567952 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 567953..567972 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 568035..569096 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" /label="gutB CDS" gene 568035..569096 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /label="gutB gene" CDS 569170..570561 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" /label="gutP CDS" gene 569170..570561 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /label="gutP gene" promotor_-35 570588..570595 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 570609..570628 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 570614 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="upshifts" CDS 570656..571618 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" /label="ydjE CDS" gene 570656..571618 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /label="ydjE gene" downshifts 571603 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 571743..571752 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 571759 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 571765..571780 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 571814..572497 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" /label="pspA CDS" gene 571814..572497 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /label="pspA gene" S_feature 572498..572562 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 572563..573588 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" /label="ydjG CDS" gene 572563..573588 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /label="ydjG gene" CDS 573588..574352 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" /label="ydjH CDS" gene 573588..574352 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /label="ydjH gene" CDS 574383..575354 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" /label="ydjI CDS" gene 574383..575354 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /label="ydjI gene" downshifts 575344 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 575388 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(575401..576426) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" /label="ydjJ CDS" gene complement(575401..576426) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /label="ydjJ gene" promotor_-10 complement(576458..576477) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(576476) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(576491..576497) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 576686..576693 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 576706 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="upshifts" S_feature 576708..577010 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 576708..576727 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 577011..578432 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" /label="iolT CDS" gene 577011..578432 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /label="iolT gene" downshifts 578424 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(578480) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(578480..579520) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" /label="bdhA CDS" gene complement(578480..579520) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /label="bdhA gene" promotor_-35 579060..579069 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 579083..579102 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 579084..579619 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 579084 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(579521..579815) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 579620..579639 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 579621..579918 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 579621 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="upshifts" misc_feature complement(579810..579824) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(579815) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 579917..579936 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 579920 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="upshifts" CDS 579959..580330 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" /label="walM CDS" gene 579959..580330 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /label="walM gene" downshifts 580316 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS 580396..581442 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" /label="ydjN CDS" gene 580396..581442 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /label="ydjN gene" downshifts 581416 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(581476..581634) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" /label="ydzJ CDS" gene complement(581476..581634) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /label="ydzJ gene" downshifts complement(581492) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(581691..581823) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(581734) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(581824..582033) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" /label="ydjO CDS" gene complement(581824..582033) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /label="ydjO gene" promotor_-10 complement(582066..582085) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582077) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" CDS complement(582116..582931) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" /label="ydjP CDS" gene complement(582116..582931) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /label="ydjP gene" promotor_-35 582758..582767 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 582780..582799 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 582780 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(582944..583933) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" /label="yeaA CDS" gene complement(582944..583933) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /label="yeaA gene" promotor_-10 complement(583798..583816) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(583806) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(583832..583837) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(583955..583970) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(583976) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(583982..583991) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(584031..585572) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" /label="cotA CDS" gene complement(584031..585572) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /label="cotA gene" downshifts complement(584044) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(585603..585622) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(585617) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="upshifts" promotor_-35 complement(585636..585645) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(585724..587133) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" /label="gabP CDS" gene complement(585724..587133) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /label="gabP gene" downshifts complement(585738) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(587171..587458) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" /label="ydzX CDS" gene complement(587171..587458) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /label="ydzX gene" misc_feature complement(587174..587193) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(587188) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="upshifts" promotor_-35 587464..587471 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 587487..587506 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 587488 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="upshifts" CDS 587531..588403 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" /label="mneS CDS" gene 587531..588403 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /label="mneS gene" downshifts 588368 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(588643) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" /label="downshifts" misc_feature 588697..588716 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 588707 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="upshifts" CDS 588753..589715 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" /label="yeaC CDS" gene 588753..589715 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /label="yeaC gene" CDS 589715..590911 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" /label="yeaD CDS" gene 589715..590911 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /label="yeaD gene" CDS 590933..593146 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" /label="yebA CDS" gene 590933..593146 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /label="yebA gene" promotor_-35 593141..593148 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 593163..593182 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 593179..593308 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 593179 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="upshifts" CDS 593309..594850 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" /label="guaA CDS" gene 593309..594850 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /label="guaA gene" downshifts 594836 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 594957..594961 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 594977..594996 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 594987 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="upshifts" misc_RNA 594994..595096 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswC RNA" gene 594994..595096 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /label="gswC gene" downshifts 595122 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 595231..596553 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" /label="pbuG CDS" gene 595231..596553 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /label="pbuG gene" downshifts 596531 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 596574 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" /label="downshifts" promotor_-35 596603..596612 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 596623..596763 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 596623 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 596625..596640 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 596764..597567 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" /label="yebC CDS" gene 596764..597567 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /label="yebC gene" downshifts 597552 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 597635..597642 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 597656..597675 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 597662..597725 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 597662 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="upshifts" CDS 597726..597893 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" /label="yebD CDS" gene 597726..597893 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /label="yebD gene" downshifts 597900 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 597944..597950 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 597965..597983 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 597968..598054 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 597968 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 598033..598040 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 598054..598073 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 598056 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="upshifts" CDS 598107..598661 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" /label="yebE CDS" gene 598107..598661 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /label="yebE gene" CDS 598661..598858 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" /label="yebG CDS" gene 598661..598858 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /label="yebG gene" downshifts 598848 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 598904..598911 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 598926..598945 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 598928 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 598938..599040 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswD RNA" gene 598938..599040 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /label="gswD gene" S_feature 599041..599180 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 599181..599669 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" /label="purE CDS" gene 599181..599669 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /label="purE gene" CDS 599662..600804 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" /label="purK CDS" gene 599662..600804 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /label="purK gene" CDS 600801..602096 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" /label="purB CDS" gene 600801..602096 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /label="purB gene" promotor_-10 complement(601106..601125) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(601127) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(601140..601147) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 602170..602895 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" /label="purC CDS" gene 602170..602895 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /label="purC gene" CDS 602888..603142 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" /label="purS CDS" gene 602888..603142 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /label="purS gene" CDS 603139..603822 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" /label="purQ CDS" gene 603139..603822 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /label="purQ gene" CDS 603806..606034 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" /label="purL CDS" gene 603806..606034 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /label="purL gene" downshifts complement(604054) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" /label="downshifts" CDS 606010..607440 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" /label="purF CDS" gene 606010..607440 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /label="purF gene" S_feature 607441..607541 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 607542..608582 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" /label="purM CDS" gene 607542..608582 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /label="purM gene" CDS 608579..609166 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" /label="purN CDS" gene 608579..609166 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /label="purN gene" misc_feature 608589..608603 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 608598 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(608865..608883) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(608872) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(608899..608904) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 609163..610701 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" /label="purH CDS" gene 609163..610701 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /label="purH gene" CDS 610717..611985 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" /label="purD CDS" gene 610717..611985 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /label="purD gene" downshifts 611970 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(612025..612444) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" /label="yezC CDS" gene complement(612025..612444) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /label="yezC gene" misc_feature complement(612514..612533) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(612523) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="upshifts" CDS 612588..613862 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" /label="yecA CDS" gene 612588..613862 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /label="yecA gene" downshifts 613811 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" /label="downshifts" CDS complement(613877..614104) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" /label="yezF CDS" gene complement(613877..614104) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /label="yezF gene" downshifts complement(613888) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(614105..614525) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 614172..614177 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 614188 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 614191..614210 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 614233..615975 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" /label="yerA CDS" gene 614233..615975 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /label="yerA gene" promotor_-10 complement(614510..614521) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(614525) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(614535..614541) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 614556 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" /label="downshifts" promotor_-35 615949..615955 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 615967 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 615968..615987 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 616002..616997 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" /label="yerB CDS" gene 616002..616997 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /label="yerB gene" CDS 617000..617314 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" /label="yerC CDS" gene 617000..617314 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /label="yerC gene" downshifts 617177 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" downshifts 617319 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" /label="downshifts" CDS complement(617349..618926) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" /label="yerD CDS" gene complement(617349..618926) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /label="yerD gene" downshifts complement(617363) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(618940..618959) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(618959) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(618974..618980) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 619123..619126 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 619140 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 619143..619162 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 619191..619877 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" /label="pcrB CDS" gene 619191..619877 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /label="pcrB gene" CDS 619939..622158 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " /label="pcrA CDS" gene 619939..622158 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /label="pcrA gene" CDS 622182..624188 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" /label="ligA CDS" gene 622182..624188 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /label="ligA gene" CDS 624204..625394 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" /label="yerH CDS" gene 624204..625394 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /label="yerH gene" misc_feature complement(624399..624403) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(624403) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 625431..625450 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 625439..625555 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 625439 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(625503) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" CDS 625556..626566 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" /label="yerI CDS" gene 625556..626566 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /label="yerI gene" promotor_no_box complement(625573..625673) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(625613) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 626549 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 626593..627397 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(626604..627302) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" /label="sapB CDS" gene complement(626604..627302) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /label="sapB gene" downshifts complement(626625) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(627322..627340) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(627343) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(627356..627361) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(627409..628887) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" /label="opuE CDS" gene complement(627409..628887) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /label="opuE gene" downshifts complement(627423) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" /label="downshifts" upshifts complement(628275) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(628278..628291) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(628888..629018) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(629009..629027) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(629018) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(629042..629048) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 629149..629152 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 629167..629300 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 629167 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 629169..629188 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 629301..629591 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" /label="gatC CDS" gene 629301..629591 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /label="gatC gene" CDS 629607..631064 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" /label="gatA CDS" gene 629607..631064 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /label="gatA gene" CDS 631078..632508 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" /label="gatB CDS" gene 631078..632508 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /label="gatB gene" downshifts 632489 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(632523..633392) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" /label="yerO CDS" gene complement(632523..633392) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /label="yerO gene" downshifts complement(632565) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 633182..633187 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 633203..633221 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 633215 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="upshifts" S_feature complement(633393..633467) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 633445..633452 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(633461..633480) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 633467 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 633468..633487 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(633474) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(633495..633502) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 633524..636682 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" /label="srfP CDS" gene 633524..636682 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /label="srfP gene" downshifts 636669 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 636921..636924 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 636939..636958 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 636947 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="upshifts" CDS 637005..637916 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" /label="dagK CDS" gene 637005..637916 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /label="dagK gene" S_feature 637917..638171 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 638172..639551 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" /label="rlmCD CDS" gene 638172..639551 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /label="rlmCD gene" S_feature 639552..640144 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" CDS complement(639564..640466) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1779754, 1762151; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase / invertase; HGT island" /protein_id="NP_388556.1" /db_xref="EnsemblGenomes-Gn:BSU06740" /db_xref="EnsemblGenomes-Tr:CAB12494" /db_xref="GOA:O34574" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="SubtiList:BG12827" /db_xref="UniProtKB/Swiss-Prot:O34574" /translation="MYNEGVTSPSQLARKKNATDKWHGSSIRKILENPHYTGTLQQCR EYRPSVTSKRRRSVNLENQIIIEKSHEPIIPLEDFLIVQEILITRKRRRPQAEVHLFT NTAVCKDCRRSMHFKKNRKGYVCGSYNKHGLKACSDHYVSEIDLTDKVITNLNKIYLK FSKENYFKELSEKALKYKEKIESKIIEINEKLNDKKRDKSNLVISLANGVISKEDYQL AINITNEDISNFETTLHQLSKDLEFQKIEKEIIDFKKSLDKFMKEGTLTPEMLHLLVD EIEVHANGTIEINYRFREPTVPSA*" /label="yefB CDS" gene complement(639564..640466) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /label="yefB gene" downshifts 640101 /Source="Nicolas_upshifts" /id="D334" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="4.70474" /MaxDrop="2.82299" /score="-8.81916201" /energy="-8.8" /TU="U518" /idTUdmin="U516" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 640146..640446 /Source="Nicolas_S_feature" /locus_tag="new_739577_739877" /HighExp="H2O2, Cold, G180, G135, G150, Paraq, Oxctl, C30, LPh, LBGexp" /AntisenseName="yefB" /AntisenseCor="0.202214664414261" /AntisenseRegPval="-3.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S241" CDS 640447..640782 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative resolvase; HGT island" /protein_id="NP_388557.2" /db_xref="EnsemblGenomes-Gn:BSU06750" /db_xref="EnsemblGenomes-Tr:CAB12495" /db_xref="GOA:O35034" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG12828" /db_xref="UniProtKB/Swiss-Prot:O35034" /translation="MTPSLYNPLAIASKPFPAIYSEKILIFTIFSAFAEFERDMIVER TQEGKMLAKQNPDFREGRPKKFTKQQINHALTLLENHSYKQVEDMTGISVSTLVRAKK KKAAEAING*" /label="yefC CDS" gene 640447..640782 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /label="yefC gene" S_feature 640783..640856 /Source="Nicolas_S_feature" /locus_tag="new_740214_740287" /HighExp="G180, H2O2, G150, Cold, G135, Paraq, Oxctl, C30, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S242" CDS 640857..643496 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative restriction type II methylase; HGT island" /protein_id="NP_388558.1" /db_xref="EnsemblGenomes-Gn:BSU06760" /db_xref="EnsemblGenomes-Tr:CAB12496" /db_xref="GOA:O31504" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12818" /db_xref="UniProtKB/Swiss-Prot:O31504" /translation="MALIDLEDKIAEIVNREDHSDFLYELLGVYDVPRATITRLKKGN QNLTKRVGEVHLKNKVWFKEAKKGKLFDALIDIEQQVEYLSAKPRYLLVTDYDGVLAK DTKTLEALDVKFEELPQYFDFFLAWKGIEKVEFEKENPADIKAAERFARIYDVLRKEN NIIETNRGLDLFLIRLLFCFFAEDTDIFKRNSFTNLIKTLTEEDGSNLNKLFADLFIV LDKNERDDVPSYLKEFPYVNGQLFTEPHTELEFSAKSRKLIIECGELLNWAKINPDIF GSMIQAVASEESRSYLGMHYTSVPNIMKVIKPLFLDKLNQSFLDAYDDYTKLENLLTR IGKIKFFDPACGSGNFLIITYKELRRMEINIIKRLQELLGEYLYVPSVTLSQFYGIEI EDFAHDVAKLSLWIAEHQMNEELKNEVHNAVRPTLPLHTAGDIRCANAIRVEWTEVCP AQGSEEVYVFGNPPYLGSKKQNKEHKSDMLSIFGKVKNGKMLDYISAWFYFGAKYAST TNAKVAFVSTNSVTQGEQVSILWNELFKFGIQINFAYKSFKWANNAKNNAAVIVVIVG FGPLDTKVNKYLFVDETKKLVSNISPYLTDGENILVSSRTKPISDLPKLHFGNMPNDG GGLLFTITEYTDAINKYPELVPYFKKFIGSVEFINGGLRYCLWLNEAKYEKIKSNPLI QERISISKNHREKSTDKGTNKLALTPWKFRDTHETTNYSIVVPSVSSENRFYIPMGLA GADTILSNLIYVIYDAEIYLLGILMSRMHMTWVKAVAGRLKTDYRYSAGLCYNTFPIP ELSTRRKNEIEEAILEILDLREEQGGTLAELYNPSTMPIELKVAHEKLDGIVERAYRQ KQFESDEERLEVLLKLYQEMTER*" /label="yeeA CDS" gene 640857..643496 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /label="yeeA gene" CDS 643508..645307 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA helicase / endonuclease; HGT island" /protein_id="NP_388559.2" /db_xref="EnsemblGenomes-Gn:BSU06770" /db_xref="EnsemblGenomes-Tr:CAB12497" /db_xref="GOA:O34469" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12819" /db_xref="UniProtKB/Swiss-Prot:O34469" /translation="MENIIEINYNQTGKSKKTNEYGMREMQARAFEKRNSQYLLVKAP PASGKSRALMFIGLDKLINQGLRKVIVAVPERSIGSSFKNTDLKSYGFFENWKVDPRN NLTVGGDNSKVKSFVRFMESDDQVLICTHSTLRFAFEKIDDKAFDNCLLAIDEFHHVS ADVNSRLGELLRSIIHNSSAHIVAMTGSYFRGDSVPILLPEDEELFDKVTYSYYEQLD GYEYLKGFGIGYHFYQGQYTSAINEVLDTNKKTIVHIPNVNSGESTKDKYDEVGKILD MIGEVEYQDDDTGIIYVKRHSDGKTLKIADLVDDQVGRENVVAYLRNIEALDDLDIII ALGMAKEGFDWPFCEHTLTVGYRGSLTEIVQIIGRCTRDSYNKTYAQFTNLIAMPDAK DEVVTYTVNTMLKAISASLLMEQVLTPDFKFKRRRNESEKSSTTGELFVKGLKEPSTE NVKKIIENDINDLKAKIMQDSQVQKTFSGEVDPKVLNKVLIPKVIQKVYPNLSDEEIE EVRQHVVLDTVMKGAKSEVVGSKEFIRMADKFINIEDLDINLIDSINPFQKAFEVLSK ELNSPVLKLIQETIDAKRINFDEDELVFIWPKV*" /label="yeeB CDS" gene 643508..645307 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /label="yeeB gene" promotor_-10 complement(643748..643763) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(643763) /Source="Nicolas_upshifts" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(643775..643784) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 645308..645419 /Source="Nicolas_S_feature" /locus_tag="new_744739_744850" /HighExp="Cold, G180, G135, G150, H2O2, Paraq, HPh, LPh, Oxctl, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S243" CDS 645420..646568 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388560.2" /db_xref="EnsemblGenomes-Gn:BSU06780" /db_xref="EnsemblGenomes-Tr:CAB12498" /db_xref="InterPro:IPR018306" /db_xref="SubtiList:BG12820" /db_xref="UniProtKB/Swiss-Prot:O34352" /translation="MASNRYHSINEIMESQLFYQITTPPKKTQKAQYDPEVEKFLEII EFVKENGREPQKVPTDLTERSLASRLIGIRKDPDRMEYLKEYDEIGLLEVRSKELTIP KISSIDDILKSGLSALLGDNLNNDITRSIFDTSSLQKVTTMPEYVAKRKKIKDFGKFE ELFKKCHKEITEGKRKILTFKNEQDIQSNSFYILKGVLLYVEDVGERKKAKGKTNARL RCIFENGTESDMLLRSLSAELYKHGRRVTDNEDTLLDNVREDDVSTGFIYVLKSLSTD PQISSIKNLYKIGFTTGSVENRIRNAENQSTYLYAPVEIVTTYQVFNMNASKFETAIH HALANNNLDVSILGANGKMLVPKEWFVVTLEDLQAVIDEIVMMVHLYD*" /label="yeeC CDS" gene 645420..646568 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /label="yeeC gene" S_feature 646569..647758 /Source="Nicolas_S_feature" /locus_tag="new_746000_747189" /HighExp="Cold, G135, H2O2, G180, G150, LPh, C30, HPh, BMM, Paraq" /AntisenseName="yeeD" /AntisenseCor="-0.41772847620445203" /AntisenseRegPval="-12.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S244" CDS complement(646830..647135) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388561.1" /db_xref="EnsemblGenomes-Gn:BSU06790" /db_xref="EnsemblGenomes-Tr:CAB12499" /db_xref="SubtiList:BG12821" /db_xref="UniProtKB/Swiss-Prot:O34950" /translation="MTVRKELIKQINLTITVIKTINQKNPTPMVKNILKRYEEAKEFI LQSSDGKFEEDLSKVRNKLDTLTRAYLESANDYMNPMLKEMHKTEKLLKEYDETTQS* " /label="yeeD CDS" gene complement(646830..647135) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /label="yeeD gene" CDS complement(647202..647408) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="hypothetical protein; HGT island" /protein_id="NP_388562.1" /db_xref="EnsemblGenomes-Gn:BSU06800" /db_xref="EnsemblGenomes-Tr:CAB12500" /db_xref="GOA:O31505" /db_xref="InterPro:IPR000290" /db_xref="InterPro:IPR035900" /db_xref="SubtiList:BG12872" /db_xref="UniProtKB/Swiss-Prot:O31505" /translation="MDKLTKEELIFLVKELMNPTLDDEKVSEYLDLLEKNVPYPAPSD LIFWSNEDYTAEQVVKIALNYKDE*" /label="yezA CDS" gene complement(647202..647408) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /label="yezA gene" CDS complement(647648..648103) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="YP_003097692.1" /db_xref="EnsemblGenomes-Gn:BSU06811" /db_xref="EnsemblGenomes-Tr:CAX52579" /db_xref="InterPro:IPR006728" /db_xref="InterPro:IPR036170" /db_xref="UniProtKB/Swiss-Prot:C0H3X4" /translation="MQDLYQLIGEKLNDIIPGEWTKIYLYAEVLDDSTMVLFHFRTPE NNQIIYSQDIPSHYNVSKDIFKTLLRELRELFEELRTEHRNNNDDVWTNLTLTLDRSG EFQLDYNYDDILASELDGYERIAIWEYKNLGILPEDEDDKEFVISYLGL*" /label="yezG CDS" gene complement(647648..648103) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /label="yezG gene" downshifts complement(647661) /Source="Nicolas_upshifts" /id="D335" /incds=0 /nref=41 /ntot=213 /MaxReadThrough="4.42275" /MaxDrop="5.23695" /score="10.2582155" /energy="-11.7" /TU="U520,U521" /idTUdmin="U520" /TUdmin="-529" /isTUend="FALSE" /label="downshifts" CDS complement(648123..650132) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein; HGT island" /protein_id="NP_388563.2" /db_xref="EnsemblGenomes-Gn:BSU06812" /db_xref="EnsemblGenomes-Tr:CAB12501" /db_xref="GOA:O31506" /db_xref="InterPro:IPR006829" /db_xref="SubtiList:BG12822" /db_xref="UniProtKB/Swiss-Prot:O31506" /translation="MKVFEAKTLLSEATDRAKEYKELRTQMVNLRKALKGVADLSDSE FSGKGASNIKAFYHDHVGVADQWIDYIDMKIAFFNSIAGAAEDKGLSDAYIEESFLEH ELANANKKSKSIMSEQKKAMKDILNDIDDILPLDLFSTETFKDELADANDKRKKTLEK LDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPIHYNAKAYRESDIHKKK GDIEKRTEAYLKIKKEEAKEREIEKLKERLKNYDYADADEFYEMAKTIGYENLTAEQQ RYFTQIENTRELEAGFKGVAVGLYDSGKDAVVGLWDMVTDPGGTVEAITGAMAHPIKT YEAISAAIEESYQKDMVNGDTYSRARWVSYAVGTVVTSIVGTKGVGAVSKTGTAAKVT TKVKTAASKSATAQKAITVSKQTVDHIKQKVNTGIEVSKKHVKTKLNQIGDLTLADIL PYHPRHDLVPAGVPYNAVNGVTLKEGLQKFAKVILPKPYGTSSSGRRTPAPHVPPVTV KYGEHFARWSRKKVLKPNIIYKTKEGYTYTTDNYGRITSVKADLQLGEAKRNQYAQTN AGKPQDRKPDDDGGHLIATQFKGSGQFDNIVPMNSQINRSGGKWYEMEQEWAKALSKK PPKKVAVQIEPVYSGDSLRPSYFDVTYKIGSRKEISVSIKNQPGG*" /label="yeeF CDS" gene complement(648123..650132) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /label="yeeF gene" promotor_-10 complement(648490..648509) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(648497) /Source="Nicolas_upshifts" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(648522..648527) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(650159..650178) /Source="Nicolas_upshift_promotors" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(650169) /Source="Nicolas_upshifts" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="upshifts" CDS 650344..651366 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage receptor protein" /protein_id="NP_388564.2" /db_xref="EnsemblGenomes-Gn:BSU06820" /db_xref="EnsemblGenomes-Tr:CAB12502" /db_xref="GOA:O31507" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12823" /db_xref="UniProtKB/Swiss-Prot:O31507" /translation="MTKKRITFGLLVLMVCVILFVLYVQLRNKDSIPVQSSAIHPEED RIFFIYSNPFIKESVLLSTSTGERFNRRTFKVADVPYIQTKSYASTDLVLLAEHEPFY YTLEKDVIKEHPLSDPFAFWYEGKDVTIEAYNVDTTGNEIHINDRKTKKEYTLTLPPL VTMGASDENFIYIIQSMSIYVIDRKTEEMIETLSLASYADQFADSEEFIVASSDHKLT VIEKGTWKTTYIAYPEDLEYADTVYYDKESGSFYVAYEDKEGGANLLEYGEDFSIHTY SLKFPYMEAKFKGNLLYIVAQEEHKKGIGGYVGVFDIHSKEMLYQFDLPEEQVKVQDF VVVDNK*" /label="yeeG CDS" gene 650344..651366 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /label="yeeG gene" promotor_-35 651466..651473 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-35" promotor_-10 651487..651506 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-10" upshifts 651488 /Source="Nicolas_upshifts" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="upshifts" CDS 651528..652658 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388565.2" /db_xref="EnsemblGenomes-Gn:BSU06830" /db_xref="EnsemblGenomes-Tr:CAB12503" /db_xref="GOA:Q59HN8" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG11031" /db_xref="UniProtKB/Swiss-Prot:Q59HN8" /translation="MSQAIPSSRVGVKINEWYKMIRQFSVPDAEILKAEVEQDIQQME EDQDLLIYYSLMCFRHQLMLDYLEPGKTYGNRPTVTELLETIETPQKKLTGLLKYYSL FFRGMYEFDQKEYVEAIGYYREAEKELPFVSDDIEKAEFHFKVAEAYYHMKQTHVSMY HILQALDIYQNHPLYSIRTIQSLFVIAGNYDDFKHYDKALPHLEAALELAMDIQNDRF IAISLLNIANSYDRSGDDQMAVEHFQKAAKVSREKVPDLLPKVLFGLSWTLCKAGQTQ KAFQFIEEGLDHITARSHKFYKELFLFLQAVYKETVDERKIHDLLSYFEKKNLHAYIE ACARSAAAVFESSCHFEQAAAFYRKVLKAQEDILKGECLYAY*" /label="rapH CDS" gene 651528..652658 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /label="rapH gene" CDS 652648..652821 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type r: regulator" /codon_start=1 /transl_table=11 /product="hexapeptide (TDRNTT) inhibitor of regulatory cascade" /protein_id="YP_003097693.1" /db_xref="EnsemblGenomes-Gn:BSU06839" /db_xref="EnsemblGenomes-Tr:CAX52580" /db_xref="GOA:Q59HN7" /db_xref="UniProtKB/Swiss-Prot:Q59HN7" /translation="MPIKKKVMMCLAVTLVFGSMSFPTLTNSGGFKESTDRNTTYIDH SPYKLSDQKKALS*" /label="phrH CDS" gene 652648..652821 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /label="phrH gene" downshifts 652776 /Source="Nicolas_upshifts" /id="D336" /incds=0 /nref=3 /ntot=66 /MaxReadThrough="5.5891" /MaxDrop="2.9063" /score="14.5772672" /energy="-7.6" /TU="U522" /idTUdmin="U522" /TUdmin="-901" /isTUend="FALSE" /label="downshifts" S_feature 652822..652926 /Source="Nicolas_S_feature" /locus_tag="new_752253_752357" /HighExp="S2, G/S, T2.30H, GM 150, T3.0H, T2.0H, S1, T-4.40H, T-2.40H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S245" promotor_-35 652893..652900 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 652915..652934 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 652928 /Source="Nicolas_upshifts" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="upshifts" CDS 652981..653700 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA integrase or transcriptional regulator" /protein_id="NP_388566.3" /db_xref="EnsemblGenomes-Gn:BSU06840" /db_xref="EnsemblGenomes-Tr:CAB12504" /db_xref="GOA:O31509" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026562" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG12824" /db_xref="UniProtKB/Swiss-Prot:O31509" /translation="MGRKWNNIKEKKASKDANTSRIYAKFGREIYVAAKQGEPDPESN QALKVVLERAKTYSVPKNIIERAIEKAKGGAEENYDELRYEGFGPNGSMIIVDALTNN VNRTAPEVRAAFGKNGGNMGVSGSVAYMFDATAVIGVEGKTADEALEILMEADVDVRD ILEEDDSAIVYAEPDQFHAVQEAFKNAGVEEFTVAELTMLAQSEVTLPDDAKEQFEKL IDALEDLEDVQQVYHNVDLGE*" /label="yeeI CDS" gene 652981..653700 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /label="yeeI gene" downshifts complement(652983) /Source="Nicolas_upshifts" /id="D337" /incds=0 /nref=3 /ntot=70 /MaxReadThrough="1.42969" /MaxDrop="3.99424" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-5851" /isTUend="FALSE" /label="downshifts" promotor_-35 653558..653565 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 653579..653598 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 653589 /Source="Nicolas_upshifts" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" downshifts 653682 /Source="Nicolas_upshifts" /id="D338" /incds=0 /nref=223 /ntot=271 /MaxReadThrough="4.94236" /MaxDrop="5.19148" /score="31.0415099" /energy="-11.4" /TU="U523,U524" /idTUdmin="U522" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 653769..653778 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 653792..653811 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 653795 /Source="Nicolas_upshifts" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(653799..653817) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(653819) /Source="Nicolas_upshifts" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(653833..653838) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 653834..654271 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 19060142, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 19060142, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore inner coat protein" /protein_id="NP_388567.2" /db_xref="EnsemblGenomes-Gn:BSU06850" /db_xref="EnsemblGenomes-Tr:CAB12505" /db_xref="GOA:O31510" /db_xref="SubtiList:BG12825" /db_xref="UniProtKB/Swiss-Prot:O31510" /translation="MTDTRHMYGGPGFGHYQGFGIGHPGYGMQSTGYPGYGMYGGHPG YGMQGYPDHGIHGGVGGYPGYGGYGGYPSGGYGGSPGTGSYPSMHHENDGHHHYYHHH HDGKDNLHHHHHHVGKDNHHHHHDGHYGHHHHHMGHWGKDGYK*" /label="cotK CDS" gene 653834..654271 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /label="cotK gene" downshifts complement(653841) /Source="Nicolas_upshifts" /id="D339" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.62645" /MaxDrop="3.26146" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-6709" /isTUend="FALSE" /label="downshifts" downshifts 654271 /Source="Nicolas_upshifts" /id="D340" /incds=0 /nref=82 /ntot=208 /MaxReadThrough="2.37564" /MaxDrop="8.21113" /score="17.7046271" /energy="-9" /TU="U525" /idTUdmin="U523" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 654331..654338 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 654354..654373 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 654359 /Source="Nicolas_upshifts" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="upshifts" CDS 654386..654970 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR family)" /protein_id="YP_054572.1" /db_xref="EnsemblGenomes-Gn:BSU06860" /db_xref="EnsemblGenomes-Tr:CAE01448" /db_xref="GOA:Q7WY76" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14194" /db_xref="UniProtKB/Swiss-Prot:Q7WY76" /translation="MGRNKEFDTALVLHRAIEVFGEYGYEGTSLQDLLSHLGIARQSL YDTYGTKRDLFLSAVKSYLEGKNAAVMERLEAPGSVKEAIRDIFQEGVNALRDPERAK ACYIINSAIEQIPHDPELARYFERQSKQLEDAFYHGLLRAKDQGELNGEDTDISALAR YLNQSRLSLTFIAKVTADMDRLQDHVDVSLSVLD*" /label="yezE CDS" gene 654386..654970 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /label="yezE gene" downshifts 654951 /Source="Nicolas_upshifts" /id="D341" /incds=0 /nref=26 /ntot=216 /MaxReadThrough="2.43615" /MaxDrop="3.31193" /score="17.7046271" /energy="-9" /TU="NA" /idTUdmin="U527" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 655049..655492 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388568.1" /db_xref="EnsemblGenomes-Gn:BSU06870" /db_xref="EnsemblGenomes-Tr:CAB12506" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:1S5A" /db_xref="SubtiList:BG12844" /db_xref="UniProtKB/Swiss-Prot:O31511" /translation="MLMNEFEKACETLRKFMAYMLEKDMKSWTELWDENAVFEFPYAP EGSPKRIEGKAAIYDYIKDYPKQIHLSSFTAPTVYRSADSNTVIAEFQCDGHVIETGL PYRQSYISVIETRDGRIVRYRDYWNPLVVKEAFGGSFLQTEESGK*" /label="yesE CDS" gene 655049..655492 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /label="yesE gene" CDS 655489..656349 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21494745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388569.1" /db_xref="EnsemblGenomes-Gn:BSU06880" /db_xref="EnsemblGenomes-Tr:CAB12507" /db_xref="GOA:O31512" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR008030" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11808" /db_xref="UniProtKB/Swiss-Prot:O31512" /translation="MMKQNPILITGGTGTVGSRIASRLIKLGYRVRIASRKKGALADA EYVYFNWKYASSFTPALEQVKQIYLVAPVGVFDPAPYVLPFLKEAKRLGAKRVVMQSA SVVSENGPVFGALHQAVREFPEWTVLRPSYFMQNFINVQHRMSIQTEGRITTASGEGK LGFIDADDIAETAVRALIDDVPHQTHHILTGPEALSYAEAAEIIGAAAGRRVEHVSIS RSELQHKMEAGGLPADYAHFMAKLDEAISHGAEHRVTDTVKRVTGKEPRSLSEFAAAH AAYWTSFWTE*" /label="yesF CDS" gene 655489..656349 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /label="yesF gene" promotor_-35 656411..656416 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 656432..656450 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 656432 /Source="Nicolas_upshifts" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(656454..656468) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(656459) /Source="Nicolas_upshifts" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(656476..656480) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 656476..656724 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388570.1" /db_xref="EnsemblGenomes-Gn:BSU06890" /db_xref="EnsemblGenomes-Tr:CAB12508" /db_xref="InterPro:IPR020256" /db_xref="SubtiList:BG11799" /db_xref="UniProtKB/Swiss-Prot:Q45536" /translation="MKDMQPFTPVKSYTPFHSRFDPCPPIGKKYYRTPPNLYMTFQPE HMEQFSPMEALRKGTLWKDLYDFYENPYRGGDAHGKKG*" /label="cotJA CDS" gene 656476..656724 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /label="cotJA gene" CDS 656708..656971 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388571.2" /db_xref="EnsemblGenomes-Gn:BSU06900" /db_xref="EnsemblGenomes-Tr:CAB12509" /db_xref="InterPro:IPR016571" /db_xref="InterPro:IPR024207" /db_xref="SubtiList:BG11800" /db_xref="UniProtKB/Swiss-Prot:Q45537" /translation="MAKKVDAEYYRQLEQIQAADFVLVELSLYLNTHPHDEDALKQFN QYSGYSRHLKRQFESSYGPLLQFGNSPAGKDWDWGKGPWPWQV*" /label="cotJB CDS" gene 656708..656971 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /label="cotJB gene" CDS 656986..657555 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /EC_number="1.11.1.6" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7768848, 9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7768848, 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="enzyme component of the inner spore coat" /protein_id="NP_388572.1" /db_xref="EnsemblGenomes-Gn:BSU06910" /db_xref="EnsemblGenomes-Tr:CAB12510" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG11801" /db_xref="UniProtKB/Swiss-Prot:Q45538" /translation="MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLN QRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSA LFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRF LREREIVHSMRFREAVEILKEERDKKKIF*" /label="cotJC CDS" gene 656986..657555 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /label="cotJC gene" S_feature 657556..657634 /Source="Nicolas_S_feature" /locus_tag="new_756987_757065" /HighExp="S4, S5, S3, S7, S6, B36, LoTm, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S246" promotor_-35 657607..657612 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 657627..657646 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 657636 /Source="Nicolas_upshifts" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="upshifts" CDS 657680..658222 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388573.1" /db_xref="EnsemblGenomes-Gn:BSU06920" /db_xref="EnsemblGenomes-Tr:CAB12511" /db_xref="GOA:O31513" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11809" /db_xref="UniProtKB/Swiss-Prot:O31513" /translation="MTAFKIENETIADGFYACPAVYEDAESITGLLVRTAEWLRDRGS NQWSGLLKGQDIHDITGSIEKGHVFVFKKDEELAAVVMLLPAPSEWDRTLWGDDGHEE SIYLHRLAVSRRFAGQGLGARVLQWAETGIHFPEKTRIRLDCVADSDALHSFYRRMGY EFMGADASGYHLFEKEITAE*" /label="yesJ CDS" gene 657680..658222 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /label="yesJ gene" downshifts 658189 /Source="Nicolas_upshifts" /id="D342" /incds=0 /nref=104 /ntot=251 /MaxReadThrough="3.04389" /MaxDrop="4.5316" /score="8.56782582" /energy="-5.8" /TU="U528" /idTUdmin="U530" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS 658245..658547 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388574.2" /db_xref="EnsemblGenomes-Gn:BSU06930" /db_xref="EnsemblGenomes-Tr:CAB12512" /db_xref="GOA:O31514" /db_xref="InterPro:IPR025434" /db_xref="SubtiList:BG12845" /db_xref="UniProtKB/Swiss-Prot:O31514" /translation="MSFSKREAGDVWSILFVTGIVTACLFAGVSVLMRMRFPDKSRPE WMLAGLIVLGVFAIWYSLVYVRGWEGAALGMLGFNVIFGAIAGYLIDKAIRRYRKR*" /label="yesK CDS" gene 658245..658547 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /label="yesK gene" promotor_-35 658590..658598 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 658609..658627 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 658615 /Source="Nicolas_upshifts" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="upshifts" CDS 658662..659291 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25441682; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease or sensor of a three componentsystem for pectin and rhamnogalacturonan transport anddegradation" /protein_id="NP_388575.1" /db_xref="EnsemblGenomes-Gn:BSU06940" /db_xref="EnsemblGenomes-Tr:CAB12513" /db_xref="GOA:O31515" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12846" /db_xref="UniProtKB/Swiss-Prot:O31515" /translation="MLMIHSVANGLNHFCTWVMRLAYLNVLWILFSLAGLVVFGLMPA TAAMFTVAREWAKGNTDAPVFSVFFRTFKKEWRASQILGLIVVTAALFLFADMRIAAQ MDQPVLVNVFVSISLIFAFVVLYVFPVFSHFDVKIREVLSISFFIAFSRPAVTLLMAA GAVGVLCLVLFHVTFLLFFSGSLLSLILTKLSFKAFRSMDQRQEKEKAA*" /label="yesL CDS" gene 658662..659291 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /label="yesL gene" CDS 659288..661021 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 23436677, 25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 23436677, 25441682; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YesN]" /protein_id="NP_388576.1" /db_xref="EnsemblGenomes-Gn:BSU06950" /db_xref="EnsemblGenomes-Tr:CAB12514" /db_xref="GOA:O31516" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12847" /db_xref="UniProtKB/Swiss-Prot:O31516" /translation="MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVY DEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMK QELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRN LWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMI ADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVI PFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIE AGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPH FLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTI QRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAK GCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRI VITIPCRNEVV*" /label="yesM CDS" gene 659288..661021 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /label="yesM gene" CDS 661021..662127 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25441682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YesM]" /protein_id="NP_388577.1" /db_xref="EnsemblGenomes-Gn:BSU06960" /db_xref="EnsemblGenomes-Tr:CAB12515" /db_xref="GOA:O31517" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12848" /db_xref="UniProtKB/Swiss-Prot:O31517" /translation="MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKI VHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHY LLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVA QLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKV AEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSL KWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEI GFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG*" /label="yesN CDS" gene 661021..662127 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /label="yesN gene" downshifts 662081 /Source="Nicolas_upshifts" /id="D343" /incds=0 /nref=4 /ntot=43 /MaxReadThrough="0.271749999999999" /MaxDrop="3.41261" /score="3.12085441" /energy="-10.3" /TU="NA" /idTUdmin="U531" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" promotor_-35 662166..662169 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 662184..662203 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 662191 /Source="Nicolas_upshifts" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 662231..663514 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 25658435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 25658435; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="pectin degradation byproducts (rhamnose oligosaccharides)-binding lipoprotein" /protein_id="NP_388578.2" /db_xref="EnsemblGenomes-Gn:BSU06970" /db_xref="EnsemblGenomes-Tr:CAB12516" /db_xref="PDB:4R6K" /db_xref="SubtiList:BG12849" /db_xref="UniProtKB/Swiss-Prot:O31518" /translation="MKKICYVLLSLVCVFLFSGCSAGEEASGKKEDVTLRIAWWGGQP RHDYTTKVIELYEKKNPHVHIEAEFANWDDYWKKLAPMSAAGQLPDVIQMDTAYLAQY GKKNQLEDLTPYTKDGTIDVSSIDENMLSGGKIDNKLYGFTLGVNVLSVIANEDLLKK AGVSINQENWTWEDYEKLAYDLQEKAGVYGSNGMHPPDIFFPYYLRTKGERFYKEDGT GLAYQDDQLFVDYFERQLRLVKAKTSPTPDESAQIKGMEDDFIVKGKSAITWNYSNQY LGFARLTDSPLSLYLPPEQMQEKALTLKPSMLFSIPKSSEHKKEAAKFINFFVNNEEA NQLIKGERGVPVSDKVADAIKPKLNEEETNIVEYVETASKNISKADPPEPVGSAEVIK LLKDTSDQILYQKVSPEKAAKTFRKKANEILERNN*" /label="yesO CDS" gene 662231..663514 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /label="yesO gene" CDS 663511..664440 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388579.1" /db_xref="EnsemblGenomes-Gn:BSU06980" /db_xref="EnsemblGenomes-Tr:CAB12517" /db_xref="GOA:O31519" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12850" /db_xref="UniProtKB/Swiss-Prot:O31519" /translation="MTGNGADAMKKSRSIRKDNLAGYAFISPFIIGFLCFTVIPMGAS LFLSFTSYDLFTAPKWIGLDNFKEMFTGDEKYWQSLKVTFTYVLAGVPLRLGFALFIA VILNNAAKGTAIYRTLFYLPSIIGGSVAVAIMWRNIFGNDGVINALLFFVGIDQKILW YQNPTSALWTLILLSVWQFGSSMLIFLAGLKNIPSSYLEAASVDGANRVQRFFKITLP ILTPIIFFNLVMQTISAFMTFTPAYIISKGEGGPLDGTLLYSLYLFQRAFNYFQMGYA SAMAWVMLVIVGLITLILFKTSSYWVHYESKEE*" /label="rhgP CDS" gene 663511..664440 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /label="rhgP gene" CDS 664444..665334 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388580.1" /db_xref="EnsemblGenomes-Gn:BSU06990" /db_xref="EnsemblGenomes-Tr:CAB12518" /db_xref="GOA:O31520" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12851" /db_xref="UniProtKB/Swiss-Prot:O31520" /translation="MEPVNQPVREAPVFERKKAGRVSPKRILFHVFTATLAVLLLYPV IWLFVSSFKESASIFTTSHSLIPDPFILSNYAEGWKGIAGQPFLTFIKNSAIIVGLST IGAVMSSAVIAYGFARIPFKGKKFWFACMMGTLMLPHEVLMIPQYIMFAKLDWLNSFK PIVVPQFFGHAFFIFLMIQFIRTIPEELDEAARIDGCGRFACFWRIILPLIAPALATS AIFSFYWKWEELIQPLLYLNKPELYPVSLALKLFLDTESASNWGAMFAMSAVSLLPVI LVFFLFQKYIVQGISTTGLK*" /label="rhgQ CDS" gene 664444..665334 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /label="rhgQ gene" CDS 665350..666384 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /EC_number="3.2.1.172" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan hydrolase" /protein_id="NP_388581.1" /db_xref="EnsemblGenomes-Gn:BSU07000" /db_xref="EnsemblGenomes-Tr:CAB12519" /db_xref="GOA:O31521" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="SubtiList:BG12852" /db_xref="UniProtKB/Swiss-Prot:O31521" /translation="MAQLIFDEEKVTSVIDRIVKRTFQMDFAWDWPGGVAFYGVAEAY EATENEEYINLLKTWVDEQLEDGLPPLSINGVSIGHTLLFLHKVTGDDVYLETAAEMA EYVLHKAPRFGEGILQHTVNAAEYVFPEQAWADTLMMAGLFMLRIGRVMEREDYFEDG LRQFHGHEDVLQDPVTNLYYHAWDNKAQNHLSGIYWGRANGWAALTMAKALPLIEVTH PSFMIIDGSLRDQLSALVRLQDESGLWHTILDDPDSYLEVSASAGIASALMSSGKLYT KYVQKSLAAILDAVEEDGRVSRVSAGTAVMKNAEGYKQVPYKRIQGWGQGLALTFLAD VLKTKKRLYQ*" /label="rhgH CDS" gene 665350..666384 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /label="rhgH gene" CDS 666407..668692 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19651770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19651770; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AraC/XylS family)" /protein_id="NP_388582.1" /db_xref="EnsemblGenomes-Gn:BSU07010" /db_xref="EnsemblGenomes-Tr:CAB12520" /db_xref="GOA:O31522" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG12853" /db_xref="UniProtKB/Swiss-Prot:O31522" /translation="MKKQPQQKERVSRWKGTYFKRNFVFILLIACIPGLLTGGAIYFL SIDKVEKELQRSHETQVAREVSRMDEKLGVLELALTQMAYDSSLMNGLAERDLEKDFT FSYQLTKKLFLLRDQQPLIEQASIFLNSPRPLVLSPEYSALTEQEALRKYRSLLASDH SIYWKRSGNQAMLIQLIPGAAEKPFGAIMLAVDPKEMESILQSLSPYPDGSALLLDQN REVLFHEGEKDFEKTLLHEIKKQPAENGHFQMEWKGKVYSVSFGEMNRMHQQWTFVSA APLSAITAPMVFLSKVIIVMLVICIGLAVCMTWYASKKIYRPIQHLLGLFTGGEKKTW QASGQDEFKWIEKRWQDLSLESRKLQQQLLRQTPHMKKSFLQHLLQSDFYYDNEESLR FRMEEAGWNIGGNVFHVLDLQVTGLRCEKSIFREGDEQLAVFTLTNIAEELAAKRVFQ LSILDIGRLSVTVLVMKTNSSDLKAYITELARQFGDVTGLCLTSTLSSKTERVTEIPS LFQDVKCGKSRRKFANRDQVIDLQADFPRDEQFAPYYPFELEKQIVQTIRLERKQEAK ELIDGCMKELSEKAAIDRHVHSALIQLFSRIQEDILHSGLNPSELFQHRNPFLDISEL REPNEAAAWLMDVVVTPYLSKLEGRKNRQQKQLAERVIAMIHEQYMADISLESCADAL GMNSYTLSKAFKQVTGINFIDYVTQIRIEKAKELLVNTNKKIHDVSEEVGYRHNYFNR IFKKQVGMPPGVFRQMYQETP*" /label="rhgR CDS" gene 666407..668692 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /label="rhgR gene" CDS 668706..669404 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 17957779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 17957779; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388583.1" /db_xref="EnsemblGenomes-Gn:BSU07020" /db_xref="EnsemblGenomes-Tr:CAB12521" /db_xref="GOA:O31523" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12854" /db_xref="UniProtKB/Swiss-Prot:O31523" /translation="MMKKPIQVFLAGDSTVSDCPPHEAPMAGWGQVFGQLFSEGVLVR NHAKGGASTNSFVEEGRLQAIAEHITQGDYLLIQFGHNDQKPRGTKPYSTFQQFLTLF ADTAREKGAHPVFVTSVQRRRFDENGRIEHTLGEYPDAMKALAKELDVPVIDLLAKTK VLYEAYGPEESKRLFVWFQPNEHPNYPDGIEDNTHFSEKGAMEVAKLVAEGIEELGLP LKDHLVSREGKEHV*" /label="rhgT CDS" gene 668706..669404 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /label="rhgT gene" CDS 669397..670059 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388584.1" /db_xref="EnsemblGenomes-Gn:BSU07030" /db_xref="EnsemblGenomes-Tr:CAB12522" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR015305" /db_xref="PDB:1OQ1" /db_xref="SubtiList:BG12855" /db_xref="UniProtKB/Swiss-Prot:O31524" /translation="MYKEGACLYRNPLRSKSDVKDWRMEGGGQISFDDHSLHLSHVQD EAHFVFWCPETFPDGIIVTWDFSPIEQPGLCMLFFAAAGIRGEDLFDPSLRKRTGTYP EYHSGDINALHLSYFRRKYAEERAFRTCNLRKSRGFHLAAMGADPLPSPDDADSPYRM KLIKDKGYVHFSINGLPILEWMDDGSTYGPVLTKGKIGFRQMAPMKAVYRDFAVHQAV RR*" /label="yesU CDS" gene 669397..670059 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /label="yesU gene" CDS 670056..670682 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane component" /protein_id="NP_388585.1" /db_xref="EnsemblGenomes-Gn:BSU07040" /db_xref="EnsemblGenomes-Tr:CAB12523" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12856" /db_xref="UniProtKB/Swiss-Prot:O31525" /translation="MKTTVTDALYAGCEAVVKIAWLNGLWLLFTLLGGVLFGWAPSTA AMCAVIRKWLMGQKDVPIFSLFLDTYKKEFLKVNAIGLAFSALLLILSANYHYFSAST NWLSFAVTSCTLLAGLLYIIALMYVFPLYVHYQLPLRKYIPQALLFGAMRPLTTGCML IGCGFVLYLLYTLPGLIPFYGPCLFGLVLMFFALRGFQKTEAQHHQAG*" /label="yesV CDS" gene 670056..670682 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /label="yesV gene" CDS 670803..672665 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /EC_number="4.2.2.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan endolyase" /protein_id="NP_388586.1" /db_xref="EnsemblGenomes-Gn:BSU07050" /db_xref="EnsemblGenomes-Tr:CAB12524" /db_xref="GOA:O31526" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2Z8R" /db_xref="PDB:2Z8S" /db_xref="PDB:2ZUX" /db_xref="SubtiList:BG12857" /db_xref="UniProtKB/Swiss-Prot:O31526" /translation="MRRSCLMIRRRKRMFTAVTLLVLLVMGTSVCPVKAEGAARQMEA LNRGLVAVKTDGGIFVSWRFLGTENASVLFNVYRDGQKLNAAPVKTTNYVDKNGSAGS TYTVRAVVNGTEQPASEKASVWAQPYHSVPLDKPAGGTTPKGESYTYSANDASVGDVD GDGQYELILKWDPSNSKDNSQDGYTGDVLIDAYKLDGTKLWRINLGKNIRAGAHYTQF MVYDLDGDGKAEVAMKTADGTKDGTGKVIGNANADYRNEQGRVLSGPEYLTVFQGSTG KELVTANFEPARGNVSDWGDSYGNRVDRFLAGIAYLDGQRPSLIMTRGYYAKTMLVAY NFRDGKLSKLWTLDSSKSGNEAFAGQGNHNLSIADVDGDGKDEIIFGSMAVDHDGKGM YSTGLGHGDALHTGDLDPGRPGLEVFQVHEDKNAKYGLSFRDAATGKILWGVYAGKDV GRGMAADIDPRYPGQEVWANGSLYSAKGVKIGSGVPSSTNFGIWWDGDLLREQLDSNR IDKWDYQNGVSKNMLTASGAAANNGTKATPTLQADLLGDWREEVVWRTEDSSALRIYT TTIPTEHRLYTLMHDPVYRLGIAWQNIAYNQPPHTSFFLGDGMAEQPKPNMYTP*" /label="rhgW CDS" gene 670803..672665 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /label="rhgW gene" promotor_no_box 670843..670943 /Source="Nicolas_upshift_promotors" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 670903 /Source="Nicolas_upshifts" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(671441) /Source="Nicolas_upshifts" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(671442..671461) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(671474..671483) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 672711..674549 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /EC_number="4.2.2.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan exolyase" /protein_id="NP_388587.1" /db_xref="EnsemblGenomes-Gn:BSU07060" /db_xref="EnsemblGenomes-Tr:CAB12525" /db_xref="GOA:O31527" /db_xref="InterPro:IPR013517" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2ZUY" /db_xref="SubtiList:BG12858" /db_xref="UniProtKB/Swiss-Prot:O31527" /translation="MKPKKRQMEYLTRGLIAVQTEQGVFVSWRFLGTDHETTAFHLYR DGKRITRDPIAESTNFLDQNGTADSVYQVAAVNKGREEKLSKKARVWQENVLEVPLAK PEGGVTPDGKPYTYSANDASVGDIDGDGEYEMILKWDPSNSKDNAHDGYTGEVLIDAY KLDGTFLWRINLGRNIRAGAHYTQFMVYDLDGDGKAEIAMKTADGTTDGKGHIIGDEQ ADFRNEQGRILSGPEYLTVFKGETGEALTTVEYEPPRGKLEDWGDGYGNRMDRFLAGT AYLDGERPSLVMARGYYTRTVLVAYDFRNGRLKKRWVFDSNQPGHEAYAGQGNHSLSV ADVDGDGKDEIIYGAMAVDHDGTGLYSTGLGHGDAMHVGDLDPSRKGLEVFQVHEDAT KPYGLSLRDAGTGEILWGVHAGTDVGRGMAAHIDPSYKGSLVWGIDPPGNDGMSYGLF TSKGEKISDKAPSSANFAIWWDGDLVRELLDHDWDGTIGRPKIEKWDAENGCLKTIFQ PAGVLSNNGTKGNPVLQANLFGDWREEVIWRTEDSSALRIYTTTHLTRHCFYTLMHDP VYRLGIAWQNTAYNQPPHTSFYLGTGMKKPPKPALYIAGSKAEAPL*" /label="rhgX CDS" gene 672711..674549 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /label="rhgX gene" CDS 674707..675360 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388588.1" /db_xref="EnsemblGenomes-Gn:BSU07070" /db_xref="EnsemblGenomes-Tr:CAB12526" /db_xref="GOA:O31528" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12859" /db_xref="UniProtKB/Swiss-Prot:O31528" /translation="MANHIYLAGDSTVQTYGDSTNQGGWGQFLGSHLPEHIQVINRAI GGRSSKTFVEEGRLQAILDVIEPDDWLFVQMGHNDASKNKPERYTEPYTTYKQYLKQY IAGAREKGAHPLLITPVARFHYENGVFLNDFPDYCIAMKQTAAEENVQLIDLMEKSLA FFTEKGEEKVYTYFMISEGINDYTHFTKKGANEMAKLVAKGIKELGLPLTESIIKER* " /label="yesY CDS" gene 674707..675360 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /label="yesY gene" CDS 675368..677359 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17056685, 17449691, 17485082" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17056685, 17449691, 17485082; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-galacturonidase" /protein_id="NP_388589.1" /db_xref="EnsemblGenomes-Gn:BSU07080" /db_xref="EnsemblGenomes-Tr:CAB12527" /db_xref="GOA:O31529" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12860" /db_xref="UniProtKB/Swiss-Prot:O31529" /translation="MRKLYHGACYYPELWDEETIQQDIDIMREVGVNVVRIGEFAWSV MEPEEGKIDVGFFKEIIARLYDSGIETIMCTPTPTPPIWFSHGRPERMHANEKREIMG HGSRQHACTNNPYFRKKAAIITTAIAKELGRLPGLIGWQLDNEFKCHVAECMCETCLR LWHDWLKNRYGVIERLNEAWGTDVWSETYQTFEQVPQPGPAPFLHHASLRTMYQLFSM EMIASFADEQAKIIRCYSDAPITHNGSVMFSVDNERMFQNLDFASYDTYASQENASAF LLNCDLWRNLKQGRPFWILETSPSYAASLESSAYPHADGYLQAEAVSSYALGSQGFCY WLWRQQRSGSEISHGSVLSAWGEPTIGYQNVLAVERARKEIEPIILSTEPVQAEAAMT YSDRAKAFIKTEPHRGLRHRSLVTHFYERILNTGIHRDLIPEGAPLDGYRLLFTPFVP YLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKTLFTFPM NENVNTGKAFGITAPLGLWSAVFDTESGNTLGTVEAGPGAGHAFLTERNYGEGKIVML GSLPSGKEGDAMLEALVRHYAEEAVISSRSDVTPGTIVAPRIGENGLVWIVVNMDGKG GSVTLPESGTDLLTHRLEKAGRLAVGPHEYRVIQFDNHS*" /label="rhgZ CDS" gene 675368..677359 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /label="rhgZ gene" CDS 677403..679976 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388590.2" /db_xref="EnsemblGenomes-Gn:BSU07090" /db_xref="EnsemblGenomes-Tr:CAB12528" /db_xref="SubtiList:BG12861" /db_xref="UniProtKB/Swiss-Prot:O31530" /translation="MKKIKWLSGQPKVTSGVTWGMPWKKGELKKGDRLALMNENAETR YVQSEPSAYWPDGSIKWTKHAAVFGGQENQSFTVHKREVPQPTESLSILETEHDIQVD TGALVCTIHKTGSDFIQSLQINGKPIAAGGRLVAIRETRKESAAKMVLLHERSVSFIK RAAIEQSGPVKAVVKIEGVHVLHKTYEEWLPFVIRLTFYAGLSEIGLVHTQLIDRSGK LEFVKGLGIEFDLFLEGEPYNRHFRFAGEKGMYKEPAQLFGTRKFNERYPLYEKQING EMLSPDEEHKEWFAHGTQNAVWDDVKIVQDSSDHYSLSKRTGKDYAWVGMLHGSRAKG LCYAGGKNGGVALGLRYFFEKYPSALEITGLAGSRPKMTIWLWPPDGEAMDLRHYTGN THVASAYEGFDEMRSDPTGIANTNEISLACFSHMPSDEVLNALADKWQAPPLIVCEPD VYYESKALGVWSIIDTSHPLKKELEEQLDAAFLFYKKEVEQRRWYGFWHYGDVMHTYD PIRHMWRYDLGGYAWQNNELVPTLWLWQAFFRSGREDIFRMAEAMTRHTSETDSFHLG EYAGLGSRHNVVHWGCGCKEARISMAGLHKFYYYLTGDDRTGDLLTEVKDADYALVKT DPMRAFYEKGKHPTHARTGPDWAAFCSNWLAEWERTENSEYLKKIETGINCLKRLPLR LLSGPTFEYDPATSMLHHMGDGIAGGYHMIIAFGAPQVWMELAELLDDWEWEDMLSEF GEFYTLSDEEKRKKSGGALHDGHFHWPMFAAGMTAYAARKKQDPHLAAKAWNLLLEDK LSHTPLPIKPERIETWTQLEELPWVTTNTVSQWCLNVIAALELIGDSLPAKKETSGKK G*" /label="yetA CDS" gene 677403..679976 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /label="yetA gene" promotor_-10 complement(678725..678743) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(678738) /Source="Nicolas_upshifts" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(678759..678764) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 680098..681606 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921237; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein transporter binding protein for alpha-galacturonides" /protein_id="NP_388591.1" /db_xref="EnsemblGenomes-Gn:BSU07100" /db_xref="EnsemblGenomes-Tr:CAB12529" /db_xref="GOA:P37966" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG10434" /db_xref="UniProtKB/Swiss-Prot:P37966" /translation="MKIRMRKKWMALPLAAMMIAGCSHSETSNSASGSKDTIKIMAPL LSPESPSDKSPSLKALEKYTGKEIKVTWVPDSSYNDKFNIVMASGEMPHAIVIKDKSA GFIKSVKAGAFWELSPYLKDYKNLSQADEKILKNSSVNGEVYGIYRTRDLIRACMIIR TDWLKNVGLDMPETLDDFYEVLKAFKEKDPDGNGKDDTYGMVVPKWMGLGNGSPWDVL QIWFGAPNRYGVENGKLIPDFTTKEYMDALTFFKKLYDEGLINKDFAVMDSAKWNDPV VKGKAGVIVDTGSRASQIQSAMEEADESNKDIIDIVGSLEGPNGKRTFPTSGYSGMIT IPKSSVKTEKELKEVLSFLDKMNDKEAQILTNNGVKGRNYELKDGVFTSLEKNNKSLL YEHEGLAQFSMSIPKSEYYIEDQKTKLFQHRKDIITEGEKIAVFNPAESLVSDVYTQK GAQLDNIILDARTQFIIGEIDEKGFDDAVELWKKSGGNELMKDLNKLYQSSK*" /label="lplA CDS" gene 680098..681606 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /label="lplA gene" CDS 681661..682617 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388592.1" /db_xref="EnsemblGenomes-Gn:BSU07110" /db_xref="EnsemblGenomes-Tr:CAB12530" /db_xref="GOA:P39128" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10435" /db_xref="UniProtKB/Swiss-Prot:P39128" /translation="METVPKKRDAPVLTAGKGISWMAALKRDKWLYLLLIPGLLYFLI FKYLPMWGVLIAFKDYSPYLGFWKSEWVGFDYFKDFFMNPDFFRLLRNTLMLASLDLL FAFPAPLILALLLNEVRKAVYKRCIQTFIYVPHFVSWTIVVSITFVFFTVDTGVINKL IMSLTGEQISFLSDADWFRPMIVMQSIWKETGWGTILFLAALATVDQEQYEAAIMDGA GRFRRMWHITLPAIRSTIIVLLILRIGSFLNLGFEQVYLMTNSLNRSVADIFDTYVYM MGITQGAYSYSTAVGLFKSVVGIILIFGANYIAKKFDQEGLF*" /label="lplB CDS" gene 681661..682617 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /label="lplB gene" downshifts complement(681935) /Source="Nicolas_upshifts" /id="D344" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="1.59638" /MaxDrop="4.19822" /score="13.9744253" /energy="-20.3" /TU="NA" /idTUdmin="U538" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(681961..682061) /Source="Nicolas_upshift_promotors" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(682001) /Source="Nicolas_upshifts" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 682631..683518 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388593.1" /db_xref="EnsemblGenomes-Gn:BSU07120" /db_xref="EnsemblGenomes-Tr:CAB12531" /db_xref="GOA:P39129" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10857" /db_xref="UniProtKB/Swiss-Prot:P39129" /translation="MAEIHTMHNTKAGRVFDVCNILFLGGVGAITILPFLYIIAGSFA TEAELAQRSFFIFPKTFTLDAYKYVFSTPTFLRSMGVSIFITVVGTAVQLFFTFTMAY PLAKRHVKGRNLLLNLVIFSMLFSGGMIPTYLVVKSLGLLDTYWALILPMAINPFNLI IIKNFFQQLPRELEESAKIDGCSEIGVFWRIALPLSKPVIATFALFYAVGIWNDFFHA LLYINDSAKWPLQMVLRQVTILSDLTATNGDTMQNAVPPEQGIKLAVIVIATLPILAV YPFLQKHFAKGMLIGSVKG*" /label="lplC CDS" gene 682631..683518 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /label="lplC gene" promotor_-35 683265..683270 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 683286..683304 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 683289 /Source="Nicolas_upshifts" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="upshifts" CDS 683527..684867 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23416295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23416295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-galacturonidase" /protein_id="NP_388594.1" /db_xref="EnsemblGenomes-Gn:BSU07130" /db_xref="EnsemblGenomes-Tr:CAB12532" /db_xref="GOA:P39130" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:3FEF" /db_xref="SubtiList:BG10858" /db_xref="UniProtKB/Swiss-Prot:P39130" /translation="MFHISTLDQIKIAYIGGGSQGWARSLMSDLSIDERMSGTVALYD LDFEAAQKNEVIGNHSGNGRWRYEAVSTLKKALSAADIVIISILPGSLDDMEVDVHLP ERCGIYQSVGDTVGPGGIIRGLRAVPIFAEIARAIRDYAPESWVINYTNPMSVCTRVL YKVFPGIKAIGCCHEVFGTQKLLAEMVTERLGIEVPRREDIRVNVLGINHFTWITKAS YRHIDLLPIFREFSAHYGESGYELEGECWRDSVFCSAHRVAFDLFETYGAIPAAGDRH LAEFLPGPYLKQPEVWKFHLTPISFRKQDRAEKRQETERLIVQQRGVAEKASGEEGVN IIAALLGLGELVTNVNMPNQGQVLNLPIQAIVETNAFITRNRVQPILSGALPKGVEML AARHISNQEAVADAGLTKDTGLAFQAFLNDPLVQIDRSDAEQLFNDMLQCIMQS*" /label="lplD CDS" gene 683527..684867 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /label="lplD gene" S_feature complement(683961..685652) /Source="Nicolas_S_feature" /locus_tag="new_783392_785083_c" /HighExp="H2O2, dia15, Paraq, Lbexp, LBGexp, Salt, LPhT, GM 25, G150, dia0" /AntisenseName="yetF" /AntisenseCor="-0.25986434675098202" /AntisenseRegPval="-4.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S247" S_feature 684868..684949 /Source="Nicolas_S_feature" /locus_tag="new_784299_784380" /HighExp="S5, S4, S6, S3, S7, S8, BT, LoTm, B36, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S248" CDS 684950..685645 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388595.1" /db_xref="EnsemblGenomes-Gn:BSU07140" /db_xref="EnsemblGenomes-Tr:CAB12533" /db_xref="GOA:O31533" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="PDB:3C6F" /db_xref="SubtiList:BG12862" /db_xref="UniProtKB/Swiss-Prot:O31533" /translation="MGNYLSVAVELVCGLGILFIILKLLGKTQFSQITPFDFISALIL GELVGNAVYDHEIKIKEIIFASLLWGVLIYIIEFITQKMKSSRKFLEGEPNIVIRKGE LQYKVMKKNKIDINQLQSLLRQAGSFSIQEVEYAILETNGMVSVLPKSDFDKPTNKDL QIPSKSVSLPITLIIDGEIVRDNLKEAGVDEQWLKQELKKKNIDKTEDVLFAEWHKNK PLYTVTYEQSRST*" /label="yetF CDS" gene 684950..685645 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /label="yetF gene" downshifts 685643 /Source="Nicolas_upshifts" /id="D345" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.32891" /MaxDrop="3.45213" /score="-0.176154378" /energy="-7.1" /TU="NA" /idTUdmin="U537" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(685682..686008) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /EC_number="1.14.14.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20180905, 21764939, 21873409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20180905, 21764939, 21873409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388596.2" /db_xref="EnsemblGenomes-Gn:BSU07150" /db_xref="EnsemblGenomes-Tr:CAB12534" /db_xref="GOA:O31534" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12863" /db_xref="UniProtKB/Swiss-Prot:O31534" /translation="MFVQLRKMTVKEGFADKVIERFSAEGIIEKQEGLIDVTVLEKNV RRGDEEVVVMIRWESEDHWKQWEKSDAHIAGHKANKGKPKPDYLISTEVSMYHVRAVK QGTYNQ*" /label="hmoA CDS" gene complement(685682..686008) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /label="hmoA gene" downshifts complement(685697) /Source="Nicolas_upshifts" /id="D346" /incds=0 /nref=194 /ntot=248 /MaxReadThrough="4.01189" /MaxDrop="6.29183" /score="9.23596913" /energy="-9.1" /TU="U538" /idTUdmin="U539" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 685995 /Source="Nicolas_upshifts" /id="D347" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.96802" /MaxDrop="3.46057" /score="-7.34187128" /energy="-5" /TU="NA" /idTUdmin="U537" /TUdmin=352 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(686031..686050) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(686049) /Source="Nicolas_upshifts" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(686065..686072) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(686112..686474) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase/dioxygenase" /protein_id="NP_388597.1" /db_xref="EnsemblGenomes-Gn:BSU07160" /db_xref="EnsemblGenomes-Tr:CAB12535" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12864" /db_xref="UniProtKB/Swiss-Prot:O31535" /translation="MIKQIGTVAVYVEDQQKAKQFWTEKVGFDIAADHPMGPEASWLE VAPKGAETRLVIYPKAMMKGSEQMKASIVFECEDIFGTYEKMKTNGVEFLGEPNQMEW GTFVQFKDEDGNVFLLKE*" /label="yetH CDS" gene complement(686112..686474) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /label="yetH gene" promotor_-10 complement(686497..686516) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-10" upshifts complement(686511) /Source="Nicolas_upshifts" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="upshifts" promotor_-35 complement(686529..686535) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-35" S_feature complement(686545..687105) /Source="Nicolas_S_feature" /locus_tag="new_785976_786536_c" /HighExp="S8, S6, S7, S5, BT, B36, G/S, B60, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S249" downshifts complement(686577) /Source="Nicolas_upshifts" /id="D348" /incds=0 /nref=38 /ntot=47 /MaxReadThrough="0.395850000000001" /MaxDrop="8.2984" /score="45.4672528" /energy="-13.7" /TU="NA" /idTUdmin="U540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(687088..687107) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(687105) /Source="Nicolas_upshifts" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(687121..687130) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 687193..687200 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 687209 /Source="Nicolas_upshifts" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 687213..687232 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 687258..687839 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; N-terminal part of YetI" /db_xref="SubtiList:BG12865" /translation="MNIDQLLYQYIIDNTADITEKWFSLRCQLKGELYSASHLSEETK TLLTEQHTFTNITIASAFLEDQTDFQENMTKWAQNVAKNRVEQDVQVHEVVEAISNSR ISFWDAVATFIKENQEIVTNEDADRWNRIVNQSFDKLIIEFSEQYQKFMLMRLTSQQE LISELGCPVISIADGIGILPLIGSIDTKRHRSF*" /label="yetI CDS" gene 687258..687839 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /pseudo /label="yetI gene" CDS 687833..688129 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; C-terminal part of YetI" /db_xref="GOA:O31537" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="PSEUDO:CAB12537.2" /db_xref="SubtiList:BG12873" /db_xref="UniProtKB/Swiss-Prot:O31537" /translation="MLETVPVRCVERKITSLVVDLSGVPIVDTMVAQQLYNLSKTLFL LGVKAVFSGIRPDVAQTSIQLGLDFSEYETYGTLKQALENMGVRCIVEELEENK*" /label="yetI CDS" gene 687833..688129 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /pseudo /label="yetI gene" downshifts 688121 /Source="Nicolas_upshifts" /id="D349" /incds=0 /nref=114 /ntot=215 /MaxReadThrough="1.06939" /MaxDrop="4.8053" /score="16.356572" /energy="-21.2" /TU="NA" /idTUdmin="U541" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 688200..688207 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 688221..688240 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 688229 /Source="Nicolas_upshifts" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 688284..688451 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388600.1" /db_xref="EnsemblGenomes-Gn:BSU07190" /db_xref="EnsemblGenomes-Tr:CAB12538" /db_xref="InterPro:IPR018743" /db_xref="SubtiList:BG12875" /db_xref="UniProtKB/Swiss-Prot:O31538" /translation="MVSKSTIDPEVIEKIISSLETLDFGTVQITVHDSQITQIEKIEK HRFSLKRKESK*" /label="yezD CDS" gene 688284..688451 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /label="yezD gene" promotor_-35 688493..688500 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 688516..688535 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 688517 /Source="Nicolas_upshifts" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 688561..689205 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /function="7.4: Cations and iron carrying compounds" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 16086852, 24904158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 16086852, 24904158; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pH-sensitive calcium-leak permease (di-aspartyl pH sensor)" /protein_id="NP_388601.1" /db_xref="EnsemblGenomes-Gn:BSU07200" /db_xref="EnsemblGenomes-Tr:CAB12539" /db_xref="GOA:O31539" /db_xref="InterPro:IPR006214" /db_xref="PDB:4PGR" /db_xref="PDB:4PGS" /db_xref="PDB:4PGU" /db_xref="PDB:4PGV" /db_xref="PDB:4PGW" /db_xref="PDB:4TKQ" /db_xref="SubtiList:BG12866" /db_xref="UniProtKB/Swiss-Prot:O31539" /translation="MQATVHESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLP LSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIAGAYVVLEAFG STFVIFAVLGTIGAKMKKDLSFLWSFLLVAVLALAVVGIFNIFSPLNSAAMMAYSVIG TIVFSLYILYDLNQIKHRHITEDLIPVMALSLYLDFINLFINLLRFFGILSSDD*" /label="calJ CDS" gene 688561..689205 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /label="calJ gene" downshifts 689141 /Source="Nicolas_upshifts" /id="D350" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="6.69003" /MaxDrop="2.5446" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U541" /TUdmin=1012 /isTUend="FALSE" /label="downshifts" downshifts 689185 /Source="Nicolas_upshifts" /id="D351" /incds=0 /nref=7 /ntot=127 /MaxReadThrough="5.33515" /MaxDrop="3.71552" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" CDS 689205..690197 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388602.1" /db_xref="EnsemblGenomes-Gn:BSU07210" /db_xref="EnsemblGenomes-Tr:CAB12540" /db_xref="GOA:O31540" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12867" /db_xref="UniProtKB/Swiss-Prot:O31540" /translation="MKKRLSLDRRFLPYIKKAGGVLVKKQMGAYVSLAAAMAIVGSSV VVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLLVQSFTGVF LFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGILLAVCGVMA INLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFVSLFGFL FFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAGVSGIFTS VLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEEKTL*" /label="yetK CDS" gene 689205..690197 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /label="yetK gene" downshifts 690131 /Source="Nicolas_upshifts" /id="D352" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="4.14475" /MaxDrop="2.73453" /score="21.8095329" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 690175 /Source="Nicolas_upshifts" /id="D353" /incds=0 /nref=94 /ntot=214 /MaxReadThrough="0.120229999999999" /MaxDrop="4.45909" /score="21.8095329" /energy="-10.7" /TU="NA" /idTUdmin="U542" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(690221..690724) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19329649, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19329649, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (FlvL-flavonoids)" /protein_id="NP_388603.1" /db_xref="EnsemblGenomes-Gn:BSU07220" /db_xref="EnsemblGenomes-Tr:CAB12541" /db_xref="GOA:O31541" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12868" /db_xref="UniProtKB/Swiss-Prot:O31541" /translation="MELKHLPKYKHITEHAETYANIDAGSLELFLSLFDISKKMNHVM EHYFAGRGLSEGKFKILMLLFDAKDHRLSPTELAKRSNVTKATITGLLDGLARDGFVS RRHHTEDKRKISIELTTEGKARLEQFLPGHFSKISAVMENYSDEEKDMFVKMLGDLFE RLSVFKD*" /label="flvL CDS" gene complement(690221..690724) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /label="flvL gene" promotor_-10 complement(690749..690768) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(690757) /Source="Nicolas_upshifts" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(690782..690789) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 690887..691996 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25209494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-dependent hydroxylase/monooxygenase acting on salicylate derivatives" /protein_id="NP_388604.1" /db_xref="EnsemblGenomes-Gn:BSU07230" /db_xref="EnsemblGenomes-Tr:CAB12542" /db_xref="GOA:O06489" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12869" /db_xref="UniProtKB/Swiss-Prot:O06489" /translation="MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGIL QPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILR KTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSV VRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVF VLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWH KGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRAL KVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY*" /label="flvM CDS" gene 690887..691996 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /label="flvM gene" downshifts 691979 /Source="Nicolas_upshifts" /id="D354" /incds=0 /nref=7 /ntot=67 /MaxReadThrough="0.0953400000000002" /MaxDrop="5.1482" /score="13.261567" /energy="-12.6" /TU="NA" /idTUdmin="U542" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS complement(692031..693101) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388605.1" /db_xref="EnsemblGenomes-Gn:BSU07240" /db_xref="EnsemblGenomes-Tr:CAB12543" /db_xref="InterPro:IPR025006" /db_xref="InterPro:IPR025012" /db_xref="SubtiList:BG12870" /db_xref="UniProtKB/Swiss-Prot:O06490" /translation="MDFEIRFLSFYVIQVEGKDEQANKQFKHFQTLDTGEFEESELKD FLDGELKKIVKRKADRHPQSEQVPTKIGHFIVEPGHELDSNPNYNMFNRARLAETKED FNELSEQFVRTYLDTSAVRGGVFLVASAVPRKYFDESFVFIMKCDFEPKVARISDASS LIKKVEMAITTKNMKSIQYPYMPEEGMVEEGELKIHQASHARYFEDFLKFVEYGESMP EIMKNQVMNMVQEHVYETFEDNSEELKQFEHDIEIWEASEKREIQERLDTHQVIEASA QIIEHTPEAQLKMKVGETEIKGLLADFGDSIHLAKVNGRYVALIEAETISFEKGSSPV EFYKPEGLHEVIERIRNKTEQD*" /label="yetN CDS" gene complement(692031..693101) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /label="yetN gene" downshifts complement(692055) /Source="Nicolas_upshifts" /id="D355" /incds=0 /nref=45 /ntot=180 /MaxReadThrough="0.83729" /MaxDrop="4.28938" /score="0.323038441" /energy="-11.6" /TU="NA" /idTUdmin="U545" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(693132..693151) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(693158) /Source="Nicolas_upshifts" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(693166..693173) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 693181..693187 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 693202..693220 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 693211 /Source="Nicolas_upshifts" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="upshifts" CDS 693251..696436 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /translation="MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS VQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVA RELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIK PGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQL DEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENR ELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTL SASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSA EGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQAS ITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMV GPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTV HTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQ AVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI*" /label="cypD CDS" gene 693251..696436 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /label="cypD gene" downshifts 696423 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 696486..696491 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 696507..696525 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 696528 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 696556..696559 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 696576..696595 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 696577..696882 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 696577 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" CDS 696883..698802 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" /label="ltaSA CDS" gene 696883..698802 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /label="ltaSA gene" downshifts 698801 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 698890..698899 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 698909..699037 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 698909 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 698913..698932 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(698963) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" /label="downshifts" CDS 699038..699802 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" /label="spmH CDS" gene 699038..699802 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /label="spmH gene" CDS 699809..700777 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" /label="spmG CDS" gene 699809..700777 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /label="spmG gene" CDS 700801..701712 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" /label="yfnF CDS" gene 700801..701712 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /label="yfnF gene" promotor_-35 701590..701599 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 701612..701631 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 701615 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" CDS 701741..702919 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" /label="yfnE CDS" gene 701741..702919 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /label="yfnE gene" promotor_-35 702460..702466 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 702481..702500 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 702495 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 702920..703855 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" /label="yfnD CDS" gene 702920..703855 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /label="yfnD gene" downshifts 703727 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 703837 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(703878) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" /label="downshifts" CDS complement(703886..705115) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" /label="yfnC CDS" gene complement(703886..705115) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /label="yfnC gene" promotor_-10 complement(705144..705163) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(705162) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(705179..705186) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(705226..705933) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" /label="pynN CDS" gene complement(705226..705933) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /label="pynN gene" downshifts complement(705255) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(705956..705975) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(705979) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(706025..707410) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" /label="mtrA CDS" gene complement(706025..707410) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /label="mtrA gene" downshifts complement(706047) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(707459..707478) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(707476) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(707493..707500) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 707578..707585 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 707593 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 707599..707617 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 707660..709117 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" /label="vdhT CDS" gene 707660..709117 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /label="vdhT gene" promotor_-10 complement(708453..708472) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(708467) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(708485..708494) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 709131..709991 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" /label="yfmS CDS" gene 709131..709991 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /label="yfmS gene" downshifts 709975 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 710059..710066 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 710080..710099 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 710085 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="upshifts" CDS 710126..712015 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" /label="ettA CDS" gene 710126..712015 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /label="ettA gene" downshifts 711999 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" misc_feature 712079..712098 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 712087 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="upshifts" CDS 712138..712584 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" /label="yfmQ CDS" gene 712138..712584 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /label="yfmQ gene" downshifts complement(712140) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(712224..712227) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(712229) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(712245..712246) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 712571 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 712647..712654 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 712668..712687 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 712680 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="upshifts" CDS 712709..713131 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" /label="copP CDS" gene 712709..713131 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /label="copP gene" downshifts 712967 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS 713197..714387 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" /label="copO CDS" gene 713197..714387 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /label="copO gene" downshifts complement(714451) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS 714678..714833 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" /label="yfmN CDS" gene 714678..714833 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /label="yfmN gene" CDS complement(714953..716509) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" /label="ettM CDS" gene complement(714953..716509) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /label="ettM gene" downshifts complement(714977) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 716339..716345 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 716360..716371 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 716377 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(716559..716578) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(716563) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(716594..716598) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 716619..716622 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 716638..716657 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 716641 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" CDS 716682..717812 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" /label="yfmL CDS" gene 716682..717812 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /label="yfmL gene" downshifts 717795 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS 717880..718326 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" /label="yfmK CDS" gene 717880..718326 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /label="yfmK gene" CDS complement(718379..719398) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" /label="yfmJ CDS" gene complement(718379..719398) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /label="yfmJ gene" downshifts complement(718389) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(719419..719438) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(719423) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(719425..719879) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(719451..719458) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 719517..719524 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 719538..719557 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 719545..720642 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 719545 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="upshifts" CDS complement(719880..721100) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" /label="yfmI CDS" gene complement(719880..721100) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /label="yfmI gene" promotor_-10 complement(721137..721156) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(721144) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(721172..721179) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 721198..721205 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 721217..721392 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 721217 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 721220..721239 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 721349 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 721436..722899 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" /label="yfmG CDS" gene 721436..722899 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /label="yfmG gene" S_feature complement(721801..723471) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 722900..723393 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 723381..723386 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 723395..726660 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 723395 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 723402..723420 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(723472..724272) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" /label="fecF CDS" gene complement(723472..724272) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /label="fecF gene" CDS complement(724285..725286) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " /label="fecE CDS" gene complement(724285..725286) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /label="fecE gene" promotor_-10 complement(724872..724891) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(724884) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(724906..724913) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(725283..726284) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " /label="fecD CDS" gene complement(725283..726284) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /label="fecD gene" misc_feature complement(726354..726373) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(726356..727303) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" /label="fecC CDS" gene complement(726356..727303) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /label="fecC gene" downshifts complement(726375) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" upshifts complement(726375) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 726630..726635 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 726651..726669 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 726662..727287 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 726662 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="upshifts" misc_feature 727283..727302 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 727289..727820 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 727289 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(727345..727364) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(727352) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(727378..727385) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(727412..727780) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" /label="yfmB CDS" gene complement(727412..727780) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /label="yfmB gene" S_feature complement(727781..727893) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(727882..727901) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(727893) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="upshifts" promotor_-35 complement(727913..727920) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 727961..727967 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 727981..727999 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 727981 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 728024..728371 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" /label="yflT CDS" gene 728024..728371 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /label="yflT gene" downshifts complement(728025) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" downshifts 728367 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 728412..728492 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 728493..728512 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 728494 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="upshifts" CDS 728562..729824 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" /label="pelA CDS" gene 728562..729824 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /label="pelA gene" downshifts 729819 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-35 729877..729880 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 729895..729914 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 729903 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 729951..731387 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" /label="maeS CDS" gene 729951..731387 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /label="maeS gene" downshifts 731379 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature 731478..731497 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 731489 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="upshifts" CDS 731514..733142 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" /label="citS CDS" gene 731514..733142 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /label="citS gene" CDS 733114..733794 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" /label="citT CDS" gene 733114..733794 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /label="citT gene" CDS 733797..734756 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" /label="yflP CDS" gene 733797..734756 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /label="yflP gene" downshifts 734725 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 734848..734855 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 734868..734887 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 734879..734951 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 734879 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="upshifts" CDS 734952..736253 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" /label="citM CDS" gene 734952..736253 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /label="citM gene" promotor_-35 736250..736256 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 736270..736281 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 736271 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="upshifts" CDS 736309..737103 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" /label="yflN CDS" gene 736309..737103 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /label="yflN gene" downshifts 737079 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-35 737158..737161 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 737176..737195 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 737189 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="upshifts" CDS 737222..738313 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" /label="nosA CDS" gene 737222..738313 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /label="nosA gene" CDS complement(738304..738579) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" /label="acyP CDS" gene complement(738304..738579) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /label="acyP gene" S_feature 738314..738645 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(738593..738612) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(738607) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(738627..738634) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 738646..739311 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" /label="yflK CDS" gene 738646..739311 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /label="yflK gene" CDS complement(739352..739489) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" /label="yflJ CDS" gene complement(739352..739489) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /label="yflJ gene" downshifts complement(739366) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(739490..739620) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(739606..739624) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 739616..739621 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(739620) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 739631..740695 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 739632 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 739637..739655 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(739640..739645) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(739646..739801) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" /label="yflI CDS" gene complement(739646..739801) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /label="yflI gene" S_feature complement(739802..739907) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(739908..740222) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" /label="yflH CDS" gene complement(739908..740222) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /label="yflH gene" S_feature complement(740223..740303) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(740304..741053) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" /label="mapB CDS" gene complement(740304..741053) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /label="mapB gene" promotor_-10 complement(741082..741101) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(741095) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(741097..742233) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(741113..741121) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 741164..741165 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 741185..741204 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 741188 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="upshifts" CDS 741225..742583 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" /label="nagP CDS" gene 741225..742583 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /label="nagP gene" promotor_-10 complement(742219..742238) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(742233) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(742252..742261) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 742469 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 742579 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(742616..744565) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" /label="ltaSB CDS" gene complement(742616..744565) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /label="ltaSB gene" downshifts complement(742633) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 743675..743681 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 743697..743715 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 743701..744665 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 743701 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(744566..744640) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(744617..744636) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(744640) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(744642..745164) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(744652..744656) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 744666..744803 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" /label="yflD CDS" gene 744666..744803 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /label="yflD gene" upshifts 744781 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="upshifts" misc_feature 744782..744801 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 744822..745214 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" /label="yflB CDS" gene 744822..745214 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /label="yflB gene" promotor_-10 complement(745162..745180) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(745177) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(745196..745201) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 745283..745289 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 745304..745322 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 745304 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="upshifts" CDS 745339..746754 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" /label="yflA CDS" gene 745339..746754 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /label="yflA gene" downshifts complement(745340) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(745366..745466) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(745406) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(746751..747827) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" /label="yfkT CDS" gene complement(746751..747827) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /label="yfkT gene" S_feature 746755..750121 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(747851..748051) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" /label="yfkS CDS" gene complement(747851..748051) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /label="yfkS gene" CDS complement(748067..749221) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" /label="yfkR CDS" gene complement(748067..749221) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /label="yfkR gene" CDS complement(749202..750743) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" /label="yfkQ CDS" gene complement(749202..750743) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /label="yfkQ gene" promotor_-10 complement(750793..750804) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(750796) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(750818..750824) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 750853..750860 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 750875..750894 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 750882 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(750928) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 750936..752348 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" /label="treP CDS" gene 750936..752348 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /label="treP gene" promotor_no_box complement(750954..751054) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(750994) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 752419..754104 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" /label="treA CDS" gene 752419..754104 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /label="treA gene" promotor_-10 complement(752725..752740) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(752732) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(752753..752762) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 754077..754081 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 754097..754116 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 754100 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 754125..754841 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" /label="treR CDS" gene 754125..754841 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /label="treR gene" downshifts 754834 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" promotor_-35 754916..754919 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 754935..754954 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 754944 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 754981..755646 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" /label="hypO CDS" gene 754981..755646 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /label="hypO gene" downshifts 755627 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(755683..760071) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" /label="yfkN CDS" gene complement(755683..760071) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /label="yfkN gene" downshifts complement(755702) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(760104..760123) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(760121) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(760138..760141) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 760248..760254 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 760268..760286 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 760271 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 760314..760832 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" /label="sufLB CDS" gene 760314..760832 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /label="sufLB gene" downshifts 760818 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" /label="downshifts" downshifts complement(760862) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" /label="downshifts" S_feature 760863..762513 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(760872..762062) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" /label="yfkL CDS" gene complement(760872..762062) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /label="yfkL gene" S_feature complement(762063..762154) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(762155..762370) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" /label="yfkK CDS" gene complement(762155..762370) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /label="yfkK gene" downshifts complement(762214) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(762402..762421) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(762416) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(762436..762437) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 762483..762490 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 762505..762524 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 762515 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 762573..763043 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" /label="yfkJ CDS" gene 762573..763043 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /label="yfkJ gene" CDS 763061..763381 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" /label="yfkI CDS" gene 763061..763381 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /label="yfkI gene" CDS 763405..764232 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " /label="rbn CDS" gene 763405..764232 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /label="rbn gene" promotor_-35 764211..764217 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 764232..764243 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 764250..764406 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 764250 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(764282) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" /label="downshifts" downshifts 764381 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(764431..765606) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " /label="yfkF CDS" gene complement(764431..765606) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /label="yfkF gene" downshifts complement(764436) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" /label="downshifts" promotor_-35 765043..765049 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 765065..765083 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 765069..765722 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 765069 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(765631..765650) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(765646) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(765664..765671) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 765712..765717 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 765724 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 765732..765750 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 765774..766829 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" /label="chaA CDS" gene 765774..766829 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /label="chaA gene" promotor_-35 766843..766849 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 766864..766875 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 766868 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="upshifts" CDS 766900..767694 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" /label="yfkD CDS" gene 766900..767694 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /label="yfkD gene" downshifts 767682 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(767733..768575) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" /label="mscC CDS" gene complement(767733..768575) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /label="mscC gene" downshifts complement(767735) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(768576..769697) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" /label="yfkA CDS" gene complement(768576..769697) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /label="yfkA gene" promotor_-10 complement(769738..769757) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(769756) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(769773..769777) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 769785..769792 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 769806..769825 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 769816 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="upshifts" CDS 769842..770027 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" /label="yfjT CDS" gene 769842..770027 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /label="yfjT gene" downshifts 770006 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" /label="downshifts" promotor_-35 770070..770076 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 770082 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 770091..770102 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 770128..770919 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" /label="pdaA CDS" gene 770128..770919 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /label="pdaA gene" downshifts 770917 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(770957..771817) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" /label="yfjR CDS" gene complement(770957..771817) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /label="yfjR gene" downshifts complement(770971) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(771837..771856) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(771851) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(771872..771875) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(771916..772875) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" /label="yfjQ CDS" gene complement(771916..772875) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /label="yfjQ gene" downshifts complement(771939) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(772886..772905) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(772889) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(772921..772924) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 772936..772940 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 772954..772973 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 772963 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="upshifts" CDS 772994..773857 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" /label="yfjP CDS" gene 772994..773857 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /label="yfjP gene" S_feature 773858..773970 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 773971..775371 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" /label="yfjO CDS" gene 773971..775371 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /label="yfjO gene" downshifts 775383 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 775677..775684 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 775700..775719 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 775706 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="upshifts" S_feature 775713..775996 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 775997..776263 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" /label="yfzA CDS" gene 775997..776263 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /label="yfzA gene" promotor_-10 complement(776211..776230) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(776229) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(776245..776248) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 776264..776745 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 776716..776719 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 776736..776755 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 776747..776994 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 776747 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 776995..777972 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" /label="dusC CDS" gene 776995..777972 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /label="dusC gene" S_feature 777973..778065 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 778022 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" /label="downshifts" promotor_-35 778106..778112 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 778124..778143 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 778133 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 778168..778620 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" /label="yfjM CDS" gene 778168..778620 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /label="yfjM gene" CDS 778650..779339 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" /label="yfjL CDS" gene 778650..779339 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /label="yfjL gene" downshifts 779344 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" /label="downshifts" misc_feature 779516..779534 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 779523 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 779571..780572 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " /label="acoA CDS" gene 779571..780572 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /label="acoA gene" CDS 780576..781604 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" /label="acoB CDS" gene 780576..781604 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /label="acoB gene" CDS 781618..782814 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" /label="acoC CDS" gene 781618..782814 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /label="acoC gene" downshifts complement(781619) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" /label="downshifts" CDS 782835..784211 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" /label="acoL CDS" gene 782835..784211 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /label="acoL gene" downshifts 784205 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" /label="downshifts" promotor_-35 784258..784265 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 784278..784297 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 784286 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 784327..786144 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" /label="acoR CDS" gene 784327..786144 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /label="acoR gene" promotor_-35 786145..786151 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 786163 /Source="Nicolas_upshifts" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 786166..786177 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 786198..786377 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_388692.1" /db_xref="EnsemblGenomes-Gn:BSU08110" /db_xref="EnsemblGenomes-Tr:CAB12640" /db_xref="GOA:O31552" /db_xref="InterPro:IPR012610" /db_xref="SubtiList:BG12917" /db_xref="UniProtKB/Swiss-Prot:O31552" /translation="MNIQRAKEIVESPDMKKVTYNGVPIYIQHVNEETGTARIYPLDE PQEEHEVQLNSLKED*" /label="sspH CDS" gene 786198..786377 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /label="sspH gene" downshifts 786361 /Source="Nicolas_upshifts" /id="D407" /incds=0 /nref=96 /ntot=181 /MaxReadThrough="1.9176" /MaxDrop="6.06509" /score="5.08326573" /energy="-12" /TU="NA" /idTUdmin="U619" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(786413..786742) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388693.1" /db_xref="EnsemblGenomes-Gn:BSU08120" /db_xref="EnsemblGenomes-Tr:CAB12641" /db_xref="GOA:O31553" /db_xref="InterPro:IPR003844" /db_xref="SubtiList:BG12908" /db_xref="UniProtKB/Swiss-Prot:O31553" /translation="MMLITILLFLAAGLAEIGGGYLVWLWLREAKPAGYGIAGALILI VYGILPTFQSFPSFGRVYAAYGGVFIVLAVLWGWLVDRKTPDLYDWIGAFICLIGVCV ILFAPRG*" /label="yfjF CDS" gene complement(786413..786742) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /label="yfjF gene" downshifts complement(786427) /Source="Nicolas_upshifts" /id="D408" /incds=0 /nref=96 /ntot=245 /MaxReadThrough="2.05328" /MaxDrop="6.2642" /score="34.1179702" /energy="-15.8" /TU="NA" /idTUdmin="U623" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(786792..787250) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388694.1" /db_xref="EnsemblGenomes-Gn:BSU08130" /db_xref="EnsemblGenomes-Tr:CAB12642" /db_xref="GOA:O31554" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12907" /db_xref="UniProtKB/Swiss-Prot:O31554" /translation="MSEALTFESKYALLYLGGGLLAMIYGLITFFMAFPAFTSRGNVI FTIKTGPSGEIFLRKRSVLFSEVKRLYMGRHQYSLKGIFFEDIIIEKTDGKIVRIPTW NIITNPLFFEAVERYILPHLNEEAQNNWISQFTEVQRKAYLKEFENHPKL*" /label="yfjE CDS" gene complement(786792..787250) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /label="yfjE gene" S_feature complement(787251..787343) /Source="Nicolas_S_feature" /locus_tag="new_886682_886774_c" /HighExp="BI, BC, S2, Sw, HiOs, HiTm, S5, ferm, S4, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S282" CDS complement(787344..787901) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388695.1" /db_xref="EnsemblGenomes-Gn:BSU08140" /db_xref="EnsemblGenomes-Tr:CAB12643" /db_xref="GOA:O31555" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12906" /db_xref="UniProtKB/Swiss-Prot:O31555" /translation="MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKY YLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKK IEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAK SNWIGQFTDIQRSAYLKEFENHPKL*" /label="yfjD CDS" gene complement(787344..787901) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /label="yfjD gene" promotor_-35 787767..787772 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 787780 /Source="Nicolas_upshifts" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 787787..787805 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 787791..788378 /Source="Nicolas_S_feature" /locus_tag="new_887222_887809" /HighExp="S4, S5, S6, S3, S8, S7, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="yfjC" /AntisenseCor="9.3643586039105595E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S283" CDS complement(787933..788700) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388696.1" /db_xref="EnsemblGenomes-Gn:BSU08150" /db_xref="EnsemblGenomes-Tr:CAB12644" /db_xref="SubtiList:BG12905" /db_xref="UniProtKB/Swiss-Prot:O31556" /translation="MKQFTISIEELLFCFYSEGFFEQGMALKQAYFPEIEDEQLGALF EAACRSLLAKDAAEYRNHQYRLKDEYCPFIHVLNDADYTVKLSKFNGQGAEQNVSCHV SKFGTYSHELLFDEQVHRITKMESSEGLLAKTDEFLHIIDTEDKRESIVTLTSNEFEK LLEGASDNPSYLKEFLEKHDHQEDVTRFANDLALRKGKMDTLMRLAYGKDNTPEVADM AFVLPGAHHTWLVTGITQNEFSILPAHKDVVNQIISK*" /label="yfjC CDS" gene complement(787933..788700) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /label="yfjC gene" CDS complement(788712..789935) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388697.1" /db_xref="EnsemblGenomes-Gn:BSU08160" /db_xref="EnsemblGenomes-Tr:CAB12645" /db_xref="SubtiList:BG12904" /db_xref="UniProtKB/Swiss-Prot:O31557" /translation="MSGNIAVDPDKLEQLANDVVTELTDMENKYKDLHVELGQMILQC DPRYSSCFSGVGDAWSSGKALVTKLSDNEIFIRKTGDKFVEQDDILRKLYNAYDKYGT MTSLTALMLTQGKYYGLGLTKFVKQPSGLHTAQHSKLLLDISRAVDSSRYQKAARVLL NPKYLLKKTNRPFSDLVHKKFTKYFPQDTVDFSNSVRSYTKGFLNEAGVRSTLKDVGK TGLRFAKGNAITATLITGATETFGAGVKIAENYAKYQDKPEVLKRENAKAVGNAVNNT IFVAGGATAGAVIGGAIGSFAGPVGTVLLGAAGSYIGGVVGEQIAKYTAGFAEKAALK LKEPIHAVVDTAKKGLESAGKVVKSVNDGIDAANKSIHKGIDSAKKGMEKAKKTADSL IHGATHFLKGKFSFG*" /label="yfjB CDS" gene complement(788712..789935) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /label="yfjB gene" CDS complement(789941..790255) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388698.1" /db_xref="EnsemblGenomes-Gn:BSU08170" /db_xref="EnsemblGenomes-Tr:CAB12646" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12903" /db_xref="UniProtKB/Swiss-Prot:O31558" /translation="MDSYKVIELANKYSAAAEEVRSSKMLLESRLSALGDAWQGKARD SFDQDFEETKAAYDQFEQELLETSQELKAAAVKIEERKAEIARMEELERKAREERHKL GR*" /label="yfjA CDS" gene complement(789941..790255) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /label="yfjA gene" promotor_-10 complement(790303..790322) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(790316) /Source="Nicolas_upshifts" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(790337..790340) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 790547..790566 /Source="Nicolas_upshift_promotors" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 790550 /Source="Nicolas_upshifts" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="upshifts" CDS 790591..791940 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /EC_number="3.2.1.122" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-alpha-glucosidase" /protein_id="NP_388699.1" /db_xref="EnsemblGenomes-Gn:BSU08180" /db_xref="EnsemblGenomes-Tr:CAB12647" /db_xref="GOA:P54716" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:1U8X" /db_xref="SubtiList:BG11839" /db_xref="UniProtKB/Swiss-Prot:P54716" /translation="MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDK ERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP LKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRR LRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLM PKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMV KKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYN TGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVE KLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS* " /label="malA CDS" gene 790591..791940 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /label="malA gene" misc_feature 791969..791988 /Source="Nicolas_upshift_promotors" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 791971 /Source="Nicolas_upshifts" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="upshifts" CDS 792005..792769 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489864, 16707683, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489864, 16707683, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the Mal operon" /protein_id="NP_388700.1" /db_xref="EnsemblGenomes-Gn:BSU08190" /db_xref="EnsemblGenomes-Tr:CAB12648" /db_xref="GOA:P54717" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11847" /db_xref="UniProtKB/Swiss-Prot:P54717" /translation="MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKAC SVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKD MTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFK VNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVT LSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE*" /label="malR CDS" gene 792005..792769 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /label="malR gene" promotor_-10 complement(792149..792163) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(792179..792185) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(792179) /Source="Nicolas_upshifts" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 792784..794367 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) maltose-specificenzyme IICB component" /protein_id="NP_388701.1" /db_xref="EnsemblGenomes-Gn:BSU08200" /db_xref="EnsemblGenomes-Tr:CAB12649" /db_xref="GOA:P54715" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010975" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11848" /db_xref="UniProtKB/Swiss-Prot:P54715" /translation="MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADP DGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVS AILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKK LPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIY TFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGF ALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFIS PFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGL SFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADD TAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQV IIGLSVPQMRERVEKILNQ*" /label="malP CDS" gene 792784..794367 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /label="malP gene" downshifts 794347 /Source="Nicolas_upshifts" /id="D409" /incds=0 /nref=23 /ntot=46 /MaxReadThrough="3.26652" /MaxDrop="4.69656" /score="8.65399085" /energy="-10.9" /TU="U624" /idTUdmin="U625" /TUdmin=836 /isTUend="FALSE" /label="downshifts" promotor_-35 794396..794403 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 794418..794437 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 794426 /Source="Nicolas_upshifts" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="upshifts" CDS 794473..796194 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative xenobiotic ABC transporter subunit (ATP-binding protein)" /protein_id="NP_388702.1" /db_xref="EnsemblGenomes-Gn:BSU08210" /db_xref="EnsemblGenomes-Tr:CAB12650" /db_xref="GOA:P54718" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11849" /db_xref="UniProtKB/Swiss-Prot:P54718" /translation="MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGI LKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYS TFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLL VTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRF IKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAII NYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQH VSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDE KPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETI LKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLE AISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFG REGSESC*" /label="yfiB CDS" gene 794473..796194 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /label="yfiB gene" CDS 796188..798002 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388703.1" /db_xref="EnsemblGenomes-Gn:BSU08220" /db_xref="EnsemblGenomes-Tr:CAB12651" /db_xref="GOA:P54719" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11850" /db_xref="UniProtKB/Swiss-Prot:P54719" /translation="MLKDIRKPFQYPKLPIDKKEGAKKRAKAKDTKGTLRRIWSYLAE RKGLLILVMLMVVISAIFGLLGPFVIGKAIDHFIVGKTVSGLIPVLLLLLAIYIIQSL SLWFQNYWMITISQGTVFRMRSELFTHLHELPIPFFDKQRHGELMSRVTNDIENVSST LNTSVIQILSSVITFVGTIAVMLYMSPLLTLITLTIIPVMAASLKWITNRTGKLFKEQ QKNLGDLNGYIEESVSGAKVIKAYSREKQITAEFLEKNAALKTSGFWAQTISGFIPKV MNSLNNLSFTMIAAIGGLFALKGWISIGSIVVFAEYSRQFTRPLNDLANQFNTMLSAI AGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQTLKHLQFTVPAG QSIAFVGPTGAGKTTVTNLLARFYEPNDGKILIDGTDIKTLTRASLRKNMGFVLQDSF LFQGTIRENIRYGRLDASDQEVEAAAKTANAHSFIERLPKGYDTVLTQNGSGISQGQK QLISIARAVLADPVLLILDEATSNIDTVTEVNIQEALARLMEGRTSVIIAHRLNTIQR ADQIVVLKNGEMIEKGSHDELIRQKGFYSDLYESQFEK*" /label="yfiC CDS" gene 796188..798002 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /label="yfiC gene" downshifts 797977 /Source="Nicolas_upshifts" /id="D410" /incds=0 /nref=103 /ntot=190 /MaxReadThrough="2.4559" /MaxDrop="5.61906" /score="24.4395842" /energy="-11" /TU="NA" /idTUdmin="U627" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 798084..798091 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 798105..798124 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 798109 /Source="Nicolas_upshifts" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="upshifts" CDS 798157..798561 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16872404, 16850406, 17407181, 20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16872404, 16850406, 17407181, 20639328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase membrane subunit" /protein_id="NP_388704.1" /db_xref="EnsemblGenomes-Gn:BSU08230" /db_xref="EnsemblGenomes-Tr:CAB12652" /db_xref="GOA:P54720" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG11851" /db_xref="UniProtKB/Swiss-Prot:P54720" /translation="MNKSFEIGTLLLRVITGIIFFVHGLSKFQGMEGTIQFFGSIGLP SFMAYVIAAIELIGGVLVFFGLATRIVGVLFALTLIGAIITVKLKAPFMGNAEFDYLL LLTSIHLALTGSRFLALDPFVFKGKKNGNVSA*" /label="catD CDS" gene 798157..798561 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /label="catD gene" CDS 798579..799436 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17407181, 16872404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 16872404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase subunit" /protein_id="NP_388705.2" /db_xref="EnsemblGenomes-Gn:BSU08240" /db_xref="EnsemblGenomes-Tr:CAB12653" /db_xref="GOA:P54721" /db_xref="InterPro:IPR000486" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11852" /db_xref="UniProtKB/Swiss-Prot:P54721" /translation="MTSIHEDTHIGYAKLTIRSLERSLQFYCNVIGFQVLKKTDRQAE LTADGKRVLLILEENPSAVVLPERSVTGLYHFAILLPDRKELGIALARLIEHGIAIGH GDHAVSEALYLSDPDGNGIEMYADRPRSTWQRDREGNYVMTTTAVDIEGLLEEAGDER KTSLPNDTIIGHIHLHVSDLKEAKAFYTDVLGFDIVGNYAGMSALFVSAGGYHHHIGL NIWAGRNAPPKPTNASGLDYYTVVLPHQEELDLVANRVKHAGYSIEETENSFRVKDPV SGAYITFVI*" /label="catE CDS" gene 798579..799436 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /label="catE gene" downshifts 799423 /Source="Nicolas_upshifts" /id="D411" /incds=0 /nref=4 /ntot=21 /MaxReadThrough="0.66359" /MaxDrop="3.74886" /score="50.8573531" /energy="-19.7" /TU="NA" /idTUdmin="U628" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS 799530..800474 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family; cupin family)" /protein_id="NP_388706.1" /db_xref="EnsemblGenomes-Gn:BSU08250" /db_xref="EnsemblGenomes-Tr:CAB12654" /db_xref="GOA:P54722" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11853" /db_xref="UniProtKB/Swiss-Prot:P54722" /translation="MELNHLVTGKIALNQYVHRLEQKDVSFYVHYWGAMTNHYNTLLH KHSFYEICYVVRGEGYYLEGDRTYPLREQTIFLSKPEHLHQIKSETGLFLFYVAFELS EDQSSAEWIKVMEEVKQSPFITMQLKDGEPPGLLWKTLMLQAAQPVNAFDKEILSHLS HALILSLIQTFLPYAQRPKQKQPIHTSSALLTEVKLHIKDNLSQPLKLTDVASHFHIS GRHLSRLFAAELGVSYSEFVQNEKINKAAELLKSTNLSIKEIAEEIGFSVHYFTRVFS AKIGSSPGLFRSLYKDSKMTAFQINKPFQKIEQAKPHE*" /label="yfiF CDS" gene 799530..800474 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /label="yfiF gene" downshifts complement(800341) /Source="Nicolas_upshifts" /id="D412" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="-0.20031" /MaxDrop="3.51831" /score="-4.19869956" /energy="-9.5" /TU="NA" /idTUdmin="U632" /TUdmin=9372 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(800389..800489) /Source="Nicolas_upshift_promotors" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(800429) /Source="Nicolas_upshifts" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 800649..802097 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar/proton transporter" /protein_id="NP_388707.1" /db_xref="EnsemblGenomes-Gn:BSU08260" /db_xref="EnsemblGenomes-Tr:CAB12655" /db_xref="GOA:P54723" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11854" /db_xref="UniProtKB/Swiss-Prot:P54723" /translation="MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVING ALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIA ATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVI GQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMG DALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQ ITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLII GQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPM HVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPE TKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS*" /label="yfiG CDS" gene 800649..802097 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /label="yfiG gene" CDS 802124..803065 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_388708.1" /db_xref="EnsemblGenomes-Gn:BSU08270" /db_xref="EnsemblGenomes-Tr:CAB12656" /db_xref="InterPro:IPR011418" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11855" /db_xref="UniProtKB/Swiss-Prot:P54724" /translation="MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLN LDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLL GVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAE ACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELG SAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVV KMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ*" /label="yfiH CDS" gene 802124..803065 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /label="yfiH gene" CDS 803075..804256 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26438878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388709.1" /db_xref="EnsemblGenomes-Gn:BSU08280" /db_xref="EnsemblGenomes-Tr:CAB12657" /db_xref="GOA:P94437" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12214" /db_xref="UniProtKB/Swiss-Prot:P94437" /translation="MMLNGERIISKPLRWAMVGGGRLSQVGYKHRIGALRDNTAFQLT AGAFDIDAERGKDFGVNLGVDAERCYPNYQTMFAEEAKRQDGIEVVSIATPNGTHYEI CKAALEAGVHVICEKPLFFTSAEGQEIKALAEKKGKIVGVTYGFSGNQMLLQMRAMIE QGMIGDIRVVDLQYTHGFCATDEGEKISAAQKWRVDPAIAGPSFVLGDLSTHTYYMSQ LIMPKMKIKELLCDRQSFVGSRAPLEDNAHVLMHYENGAVGTMWTSSINAGCMDGHRI RIVGSKASIEWWDSKPNELTYEVQGEPGQTLVRGMPYLDDVCNADERLGALHSEGLSE AWANIYLKFAIAIDAKNREDEEILNNLVYPDIDAGIEGIRWIENCVRSANQGSVWVEF K*" /label="yfiI CDS" gene 803075..804256 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /label="yfiI gene" downshifts 804246 /Source="Nicolas_upshifts" /id="D413" /incds=0 /nref=40 /ntot=113 /MaxReadThrough="0.88387" /MaxDrop="5.80704" /score="14.819468" /energy="-13" /TU="NA" /idTUdmin="U630" /TUdmin="-2003" /isTUend="FALSE" /label="downshifts" promotor_-35 804316..804322 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 804337..804356 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 804355 /Source="Nicolas_upshifts" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="upshifts" CDS 804380..805582 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /function="16.12: Sense" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LinK] (linearmycin resistance, biofilm formation)" /protein_id="NP_388710.1" /db_xref="EnsemblGenomes-Gn:BSU08290" /db_xref="EnsemblGenomes-Tr:CAB12658" /db_xref="GOA:P94438" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12215" /db_xref="UniProtKB/Swiss-Prot:P94438" /translation="MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAAN HVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSV LCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQF QELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLL REWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKN AGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLV IKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGP VQQKESLS*" /label="linJ CDS" gene 804380..805582 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /label="linJ gene" CDS 805579..806241 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LinJ] (linearmycin resistance, biofilm formation)" /protein_id="NP_388711.1" /db_xref="EnsemblGenomes-Gn:BSU08300" /db_xref="EnsemblGenomes-Tr:CAB12659" /db_xref="GOA:P94439" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12216" /db_xref="UniProtKB/Swiss-Prot:P94439" /translation="MIKIIITDDQDIVREGLASLLQLREELDVIATARNGQEAFEKAK ELEPDIVLMDIRMPVSNGVEGTKLITSSLPSVKVLMLTTFKDSALIAEALEEGASGYL LKDMSADTIVKAVMTVHSGGMVLPPELTAQMLNEWKREKQLKGINEIEKPNELLDLTE REIEVLAELGYGLNNKEIAEKLYITEGTVKNHVSNIISKLAVRDRTQAAIYSVRYGVS VF*" /label="linK CDS" gene 805579..806241 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /label="linK gene" downshifts 806249 /Source="Nicolas_upshifts" /id="D414" /incds=0 /nref=114 /ntot=229 /MaxReadThrough="-0.0105699999999995" /MaxDrop="4.23231" /score="20.4785449" /energy="-7.6" /TU="NA" /idTUdmin="U630" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 806385..807320 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) biofilm formation" /protein_id="NP_388712.2" /db_xref="EnsemblGenomes-Gn:BSU08310" /db_xref="EnsemblGenomes-Tr:CAB12660" /db_xref="GOA:P94440" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12217" /db_xref="UniProtKB/Swiss-Prot:P94440" /translation="MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTI SMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMY GLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPT VGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTD LCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSL LAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD*" /label="bifL CDS" gene 806385..807320 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /label="bifL gene" CDS 807333..808523 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388713.1" /db_xref="EnsemblGenomes-Gn:BSU08320" /db_xref="EnsemblGenomes-Tr:CAB12661" /db_xref="GOA:P94441" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12218" /db_xref="UniProtKB/Swiss-Prot:P94441" /translation="MKKSIWIAWKDVKIRITDRKGFMMLILMPLILTCILGAALGSVV DGGSRIDDIKVGYIQSDQSDTANMFTKDVLKKMKSIKVTKVGSKDKMKKLIDEKKIDV GIVIPNHWEAGKTSAVVNAAPDQTLKSSIIETAASSFIEQYKAVKEAASGSMDYISKT EAVKQGKLDPAQFAEKLAKTLEKETGDKLTIAEKSVGSKAVTSFQYYSAAMLCMFMLF HITVGAKSFLQEKDTETLARMLMTPAQKSVILFGKWLGTYLFAIIQFFIFLIVTINVF GVDWGGNLLLVSVLGLSYAAAVSGISMLLASCISDMKTADAIGGFGIQLLAVLGGSML PLYQFPDVLQSVSKAVPNRWALDGFLSLMEGGGWADLQKPVLLFAAIGFCSLVIGIRR LHTR*" /label="bifM CDS" gene 807333..808523 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /label="bifM gene" CDS 808537..809694 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388714.1" /db_xref="EnsemblGenomes-Gn:BSU08330" /db_xref="EnsemblGenomes-Tr:CAB12662" /db_xref="GOA:P94442" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12219" /db_xref="UniProtKB/Swiss-Prot:P94442" /translation="MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGND DKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRS FQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKA AYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTIL EARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAV IVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQS IAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA*" /label="bifN CDS" gene 808537..809694 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /label="bifN gene" promotor_-35 808648..808653 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 808668..808686 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 808669 /Source="Nicolas_upshifts" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(809692..809766) /Source="Nicolas_S_feature" /locus_tag="new_909123_909197_c" /HighExp="LoTm, Sw, C90, HiOs, BC, MG 45, UNK1, Fru, S1, BI" /AntisenseName="yfiN" /AntisenseCor="-6.3486715356968801E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S284" downshifts complement(809735) /Source="Nicolas_upshifts" /id="D415" /incds=0 /nref=90 /ntot=257 /MaxReadThrough="1.41433" /MaxDrop="6.01369" /score="13.7314837" /energy="-11.5" /TU="U632" /idTUdmin="U632" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(809767..810315) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of phenolic acid decarboxylase" /protein_id="NP_388715.1" /db_xref="EnsemblGenomes-Gn:BSU08340" /db_xref="EnsemblGenomes-Tr:CAB12663" /db_xref="GOA:P94443" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR018309" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12220" /db_xref="UniProtKB/Swiss-Prot:P94443" /translation="MRVLKYAILGLLRKGELSGYDITSYFKEELGQFWSAKHSQIYPE LKKLTDEGFITFRTTIQGTKLEKKMYTLTDSGKQELHDWLIRHQPIPETVKDEFMLKA YFISCLSRQEASDLFKDQLQKRQAKLSDLQGSYEKLMASAEPMSFSSPDFGHYLVLTK ALEREKNYVSWLESILAMIDKD*" /label="padR CDS" gene complement(809767..810315) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /label="padR gene" S_feature complement(810316..810395) /Source="Nicolas_S_feature" /locus_tag="new_909747_909826_c" /HighExp="LoTm, Cold, G180, GM-0.2, Oxctl, T5.0H, GM 25, T3.30H, MG 60, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S285" promotor_-10 complement(810384..810403) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(810395) /Source="Nicolas_upshifts" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(810417..810422) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 810518..810521 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 810537..810556 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 810544 /Source="Nicolas_upshifts" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="upshifts" CDS 810588..811220 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11029590, 10913700, 21574267" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11029590, 10913700, 21574267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted esterase / acylglycerol lipase" /protein_id="NP_388716.1" /db_xref="EnsemblGenomes-Gn:BSU08350" /db_xref="EnsemblGenomes-Tr:CAB12664" /db_xref="GOA:Q79F14" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11951" /db_xref="UniProtKB/Swiss-Prot:Q79F14" /translation="MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGA SYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDI VAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSL NDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN*" /label="estB CDS" gene 810588..811220 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /label="estB gene" downshifts 811199 /Source="Nicolas_upshifts" /id="D416" /incds=0 /nref=7 /ntot=100 /MaxReadThrough="0.87881" /MaxDrop="2.6151" /score="0.223019698" /energy="-8.5" /TU="NA" /idTUdmin="U633" /TUdmin=88 /isTUend="FALSE" /label="downshifts" promotor_-35 811335..811340 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 811354..811373 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 811364 /Source="Nicolas_upshifts" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="upshifts" CDS 811409..812497 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 24776724, 25935415, 27303652; Product type t : transporter" /codon_start=1 /transl_table=11 /product="acetyl-glucosamine metabolite exporter componentinvolved in biofilm formation" /protein_id="NP_388717.1" /db_xref="EnsemblGenomes-Gn:BSU08360" /db_xref="EnsemblGenomes-Tr:CAB12665" /db_xref="GOA:O31559" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG12893" /db_xref="UniProtKB/Swiss-Prot:O31559" /translation="MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSF RTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAM GGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFV VTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQY RWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKI MMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNK FKYGYLFVGKIYQPKQKKVTVEVRDHAG*" /label="icaC CDS" gene 811409..812497 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /label="icaC gene" S_feature complement(811899..812287) /Source="Nicolas_S_feature" /locus_tag="new_911330_911718_c" /HighExp="S6, S8, S7, S5, LBGstat, H2O2, Mt0, Cold, G180, LPhT" /AntisenseName="yfiQ" /AntisenseCor="0.36913176163336098" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S286" upshifts complement(812287) /Source="Nicolas_upshifts" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(812289..812308) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(812321..812329) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(812533..813150) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16862575" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16862575; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388718.1" /db_xref="EnsemblGenomes-Gn:BSU08370" /db_xref="EnsemblGenomes-Tr:CAB12666" /db_xref="GOA:O31560" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1RKT" /db_xref="SubtiList:BG12894" /db_xref="UniProtKB/Swiss-Prot:O31560" /translation="MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGF SRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDV ADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATI AKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK*" /label="yfiR CDS" gene complement(812533..813150) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /label="yfiR gene" downshifts complement(812551) /Source="Nicolas_upshifts" /id="D417" /incds=0 /nref=29 /ntot=209 /MaxReadThrough="2.44114" /MaxDrop="4.07715" /score="22.1532141" /energy="-17.1" /TU="NA" /idTUdmin="U636" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(813116..814369) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811639, 15849754, 16850406, 16862575; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388719.1" /db_xref="EnsemblGenomes-Gn:BSU08380" /db_xref="EnsemblGenomes-Tr:CAB12667" /db_xref="GOA:O31561" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12895" /db_xref="UniProtKB/Swiss-Prot:O31561" /translation="MEKPLFRNQKGLMTLLASQTISSLGDWLHILAVLTLAAFQLHAS PLDMSLLMMSFALPVIVLGPVSGLLADRFDRKTIMFLSEIGRALTVISCVYVSELWQL YVLLSVQSCFSSLFLPAKNGKLKELAPEAHIQQAVSVSSIIDNSSKIFGPALGGTLIA AFSIHSVFYINAGAFFLSAVILFFLPRDAFLQKANTPQEKTAALTSIKEGLQFLKRMP LLLTGLLTACVVLFVLQIGDSQAIILIRSFSGAPPELAGWCMAVSGAGMLLTAAITGR RRITSYLLYFSAGTLLLGLATGGAPFLSGMGIAGITLFIFAFFIMGAAFGLVHIPFQI LVQTTVPVDYSGRVFGAIQSATTLASILGMAGGGVLAEWIGVSLAFLVCGCLLIMIGL ITLIGKKIAESRRYLVTKSNKGAQG*" /label="yfiS CDS" gene complement(813116..814369) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /label="yfiS gene" promotor_-10 complement(813177..813196) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(813189) /Source="Nicolas_upshifts" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(813210..813217) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(814403..814422) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(814421) /Source="Nicolas_upshifts" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(814437..814444) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 814448..814467 /Source="Nicolas_upshift_promotors" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 814453 /Source="Nicolas_upshifts" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="upshifts" CDS 814493..815029 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15581359, 22059487, 24821014, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15581359, 22059487, 24821014, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol S-transferase" /protein_id="NP_388720.1" /db_xref="EnsemblGenomes-Gn:BSU08390" /db_xref="EnsemblGenomes-Tr:CAB12668" /db_xref="GOA:O31562" /db_xref="InterPro:IPR023774" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="PDB:1RXQ" /db_xref="SubtiList:BG12896" /db_xref="UniProtKB/Swiss-Prot:O31562" /translation="MTSVNLSYPIGEYKPRESISKEQKDKWIQVLEEVPAKLKQAVEV MTDSQLDTPYRDGGWTVRQVVHHLADSHMNSYIRFKLSLTEETPAIRPYDEKAWSELK DSKTADPSGSLALLQELHGRWTALLRTLTDQQFKRGFYHPDTKEIITLENALGLYVWH SHHHIAHITELSRRMGWS*" /label="bstA CDS" gene 814493..815029 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /label="bstA gene" CDS complement(815026..816582) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388721.1" /db_xref="EnsemblGenomes-Gn:BSU08400" /db_xref="EnsemblGenomes-Tr:CAB12669" /db_xref="GOA:O31563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12897" /db_xref="UniProtKB/Swiss-Prot:O31563" /translation="MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFS VSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFP LFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFL LDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYG MTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMF QRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTD KKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEA AKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQM IPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAI SIPAFRRQKR*" /label="yfiU CDS" gene complement(815026..816582) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /label="yfiU gene" promotor_-10 complement(816604..816622) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(816621) /Source="Nicolas_upshifts" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(816638..816641) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(816693..817175) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18990441; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388722.1" /db_xref="EnsemblGenomes-Gn:BSU08410" /db_xref="EnsemblGenomes-Tr:CAB12670" /db_xref="GOA:O31564" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12898" /db_xref="UniProtKB/Swiss-Prot:O31564" /translation="MEYNLHDTTVLNENILSSEEREIWVLYMKVLTSAGLGDVSEWMK LDMSMPQMKVLMLLNNHGTLKVSDIAEKMGASLSNTTGLLDRLEKSGFVKRSHSEEDR RSVVVQLTENAKKIFRGLYEKGHLKLKRSLELLSPEEKQAVYEGLSILSRALENAKKE *" /label="yfiV CDS" gene complement(816693..817175) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /label="yfiV gene" downshifts complement(816709) /Source="Nicolas_upshifts" /id="D418" /incds=0 /nref=58 /ntot=177 /MaxReadThrough="1.47849" /MaxDrop="4.15907" /score="27.2704527" /energy="-14.2" /TU="NA" /idTUdmin="U640" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(817200..817219) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(817216) /Source="Nicolas_upshifts" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(817234..817240) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 817261..817268 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 817282..817301 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 817290 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="upshifts" CDS 817347..819917 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" /label="mprF CDS" gene 817347..819917 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /label="mprF gene" downshifts 819888 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(819935..820912) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" /label="sxzY CDS" gene complement(819935..820912) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /label="sxzY gene" downshifts complement(819946) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 820927..820934 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(820939..820958) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 820949..820968 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 820951..821042 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 820951 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(820956) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(820973..820980) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 821043..822044 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " /label="sxzZ CDS" gene 821043..822044 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /label="sxzZ gene" CDS 822041..823072 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" /label="sxzA CDS" gene 822041..823072 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /label="sxzA gene" downshifts 823053 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 823123..823125 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 823141..823160 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 823144 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 823187..824068 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" /label="yfhB CDS" gene 823187..824068 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /label="yfhB gene" promotor_-35 824079..824086 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 824102..824121 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 824111 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 824156..824740 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" /label="yfhC CDS" gene 824156..824740 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /label="yfhC gene" downshifts 824727 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(824779..824970) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" /label="yfhD CDS" gene complement(824779..824970) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /label="yfhD gene" downshifts complement(824797) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" /label="downshifts" upshifts complement(825002) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(825005..825016) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(825031..825037) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(825037..825147) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" /label="yfhE CDS" gene complement(825037..825147) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /label="yfhE gene" promotor_-10 complement(825176..825187) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(825178) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(825202..825208) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(825202..826113) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" /label="yfhF CDS" gene complement(825202..826113) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /label="yfhF gene" promotor_-35 825999..826002 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 826019..826038 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 826029..826201 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 826029 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(826135..826153) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(826149) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(826167..826173) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 826202..826996 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" /label="recX CDS" gene 826202..826996 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /label="recX gene" CDS 826998..827312 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" /label="yfhH CDS" gene 826998..827312 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /label="yfhH gene" S_feature complement(827220..827488) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 827302 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 827386..827391 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 827407..827426 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 827412 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" CDS 827455..828648 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" /label="yfhI CDS" gene 827455..828648 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /label="yfhI gene" S_feature 828649..828883 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(828681..828833) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" /label="sspK CDS" gene complement(828681..828833) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /label="sspK gene" downshifts complement(828698) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 828862..828869 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 828883..828902 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 828885..828957 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 828885 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(828892..828903) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(828902) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(828918..828924) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 828958..829227 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" /label="yfhJ CDS" gene 828958..829227 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /label="yfhJ gene" downshifts 829216 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 829305..829311 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 829326 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 829327..829345 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 829372..829890 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" /label="yfhK CDS" gene 829372..829890 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /label="yfhK gene" S_feature 829891..829958 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 829926..829935 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 829947..829962 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 829960 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="upshifts" CDS 829975..830307 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" /label="spdL CDS" gene 829975..830307 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /label="spdL gene" CDS 830294..831154 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" /label="ephM CDS" gene 830294..831154 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /label="ephM gene" downshifts 831152 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 831212..831218 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 831232..831243 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 831240..831304 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 831240 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(831262..831281) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(831271) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 831287..831293 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(831295..831296) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 831306..831386 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 831306 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 831308..831326 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 831387..832376 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" /label="csbB CDS" gene 831387..832376 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /label="csbB gene" upshifts complement(831536) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(831541..831545) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(831562..831566) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 832377..832447 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 832448..835033 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" /label="yfhO CDS" gene 832448..835033 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /label="yfhO gene" downshifts 835002 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(835026..836009) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" /label="yfhP CDS" gene complement(835026..836009) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /label="yfhP gene" downshifts complement(835060) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 835483..835492 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 835505..835524 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 835509 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(836010..836157) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 836114..836118 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 836134..836153 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 836141 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 836147..836224 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(836155..836174) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(836157) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(836189..836196) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 836225..837334 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" /label="mutY CDS" gene 836225..837334 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /label="mutY gene" promotor_-35 837171..837175 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 837191..837210 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 837203 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 837335..837647 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(837342..837566) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" /label="yfhS CDS" gene complement(837342..837566) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /label="yfhS gene" promotor_-10 complement(837596..837607) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(837598) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(837621..837627) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 837648..838400 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" /label="fabL CDS" gene 837648..838400 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /label="fabL gene" promotor_-35 838417..838423 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 838438..838449 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 838439 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(838446..838460) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(838467) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(838469..838473) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 838469..838723 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" /label="sspE CDS" gene 838469..838723 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /label="sspE gene" downshifts 838721 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(838746) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" /label="downshifts" CDS 838812..839156 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" /label="ygaB CDS" gene 838812..839156 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /label="ygaB gene" promotor_-35 838819..838827 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 838838..838856 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 838840 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="upshifts" downshifts 839139 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 839195..839202 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 839216..839235 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 839225..839299 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 839225 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="upshifts" CDS 839300..839830 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" /label="ygaC CDS" gene 839300..839830 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /label="ygaC gene" downshifts 839821 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 839918..841660 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" /label="ygaD CDS" gene 839918..841660 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /label="ygaD gene" downshifts 841647 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(841737..842798) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" /label="ygaE CDS" gene complement(841737..842798) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /label="ygaE gene" downshifts complement(841748) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature complement(842799..842889) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(842887..842906) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(842896) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(842921..842928) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(843018..844307) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" /label="gsaB CDS" gene complement(843018..844307) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /label="gsaB gene" downshifts complement(843021) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(844335..844354) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(844354) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(844356..845067) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(844366..844371) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 844400..844407 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 844421..844440 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 844421 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="upshifts" CDS 844460..844933 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" /label="bcp CDS" gene 844460..844933 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /label="bcp gene" promotor_-35 844970..844977 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 844992..845011 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 844998 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="upshifts" CDS 845056..845493 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" /label="perR CDS" gene 845056..845493 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /label="perR gene" downshifts 845475 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(845528..845881) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" /label="ygzB CDS" gene complement(845528..845881) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /label="ygzB gene" downshifts 845541 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(845551) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 845877..845881 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 845889..845903 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(845893..845912) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 845893..845984 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 845893 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="upshifts" upshifts complement(845903) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 845961..845964 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 845979..845998 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 845986..846088 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 845986 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="upshifts" CDS 846089..846973 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" /label="ygxA CDS" gene 846089..846973 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /label="ygxA gene" promotor_-35 846956..846963 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 846977..846996 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 846992..847264 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 846992 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(847025) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" rRNA 847265..848819 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-16S rRNA" gene 847265..848819 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /label="rrnD-16S gene" rRNA 848987..851914 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-23S rRNA" gene 848987..851914 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /label="rrnD-23S gene" S_feature 851915..852000 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 851976..851983 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 851997..852016 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 852002 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="upshifts" rRNA 852026..852141 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-5S rRNA" gene 852026..852141 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /label="rrnD-5S gene" tRNA 852151..852225 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="asnTA tRNA" gene 852151..852225 /gene="asnTA" /locus_tag="BSU_tRNA_29" /label="asnTA gene" tRNA 852231..852322 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Ser tRNA" gene 852231..852322 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /label="trnD-Ser gene" downshifts 852318 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" tRNA 852357..852428 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Glu tRNA" gene 852357..852428 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /label="trnD-Glu gene" tRNA 852438..852513 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Val tRNA" gene 852438..852513 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /label="trnD-Val gene" tRNA 852523..852599 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Met tRNA" gene 852523..852599 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /label="trnD-Met gene" tRNA 852611..852687 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Asp tRNA" gene 852611..852687 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /label="trnD-Asp gene" tRNA 852700..852775 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Phe tRNA" gene 852700..852775 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /label="trnD-Phe gene" tRNA 852781..852853 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Thr tRNA" gene 852781..852853 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /label="trnD-Thr gene" tRNA 852876..852960 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Tyr tRNA" gene 852876..852960 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /label="trnD-Tyr gene" tRNA 852966..853039 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Trp tRNA" gene 852966..853039 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /label="trnD-Trp gene" tRNA 853064..853139 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-His tRNA" gene 853064..853139 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /label="trnD-His gene" tRNA 853149..853220 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Gln tRNA" gene 853149..853220 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /label="trnD-Gln gene" tRNA 853270..853344 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="glyTB tRNA" gene 853270..853344 /gene="glyTB" /locus_tag="BSU_tRNA_41" /label="glyTB gene" tRNA 853350..853420 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="cysTA tRNA" gene 853350..853420 /gene="cysTA" /locus_tag="BSU_tRNA_42" /label="cysTA gene" tRNA 853428..853516 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTA tRNA" gene 853428..853516 /gene="leuTA" /locus_tag="BSU_tRNA_43" /label="leuTA gene" S_feature 853517..853593 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 853550 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature 853595..853763 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 853720..853727 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 853726 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 853741..853760 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 853765 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="upshifts" tRNA 853782..853863 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTB tRNA" gene 853782..853863 /gene="leuTB" /locus_tag="BSU_tRNA_44" /label="leuTB gene" promotor_-10 complement(853799..853816) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(853802) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(853837..853842) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(853872) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" /label="downshifts" CDS complement(853942..854718) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" /label="spo0M CDS" gene complement(853942..854718) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /label="spo0M gene" downshifts complement(853956) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(854745..854760) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(854767) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(854773..854782) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 854802..854808 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 854823..854834 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 854826 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="upshifts" CDS 854860..855063 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" /label="ygzA CDS" gene 854860..855063 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /label="ygzA gene" downshifts 855046 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(855122) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(855148..855420) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" /label="ygzC CDS" gene complement(855148..855420) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /label="ygzC gene" promotor_-10 complement(855379..855397) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(855386) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 855401..855408 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(855414..855419) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 855421..855440 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 855429 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="upshifts" CDS 855462..856154 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" /label="ygaJ CDS" gene 855462..856154 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /label="ygaJ gene" promotor_-35 856183..856187 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(856186..856205) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(856198) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 856201..856220 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(856220..856227) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 856224..856331 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswD RNA" gene 856224..856331 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /label="tswD gene" upshifts 856231 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="upshifts" downshifts 856362 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" /label="downshifts" CDS 856464..858236 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" /label="thiC CDS" gene 856464..858236 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /label="thiC gene" downshifts 858212 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature 858257..859182 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(858274..859629) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" /label="ygaK CDS" gene complement(858274..859629) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /label="ygaK gene" promotor_-10 complement(859657..859676) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(859674) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(859690..859699) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 859747..859753 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 859768..859787 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 859796 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="upshifts" CDS 859880..860077 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" /label="senS CDS" gene 859880..860077 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /label="senS gene" CDS complement(860104..861555) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" /label="katA CDS" gene complement(860104..861555) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /label="katA gene" downshifts complement(860114) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 861532..861538 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 861553..861572 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 861556 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(861573..861592) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 861578..861907 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(861592) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(861606..861613) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(861651..861669) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(861676) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" downshifts 861864 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" CDS 861963..862730 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" /label="ssuB CDS" gene 861963..862730 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /label="ssuB gene" CDS 862748..863746 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" /label="ssuA CDS" gene 862748..863746 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /label="ssuA gene" CDS 863743..864573 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" /label="ssuC CDS" gene 863743..864573 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /label="ssuC gene" CDS 864596..865726 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" /label="ssuD CDS" gene 864596..865726 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /label="ssuD gene" misc_feature 865753..865772 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 865759 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="upshifts" CDS 865830..866366 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" /label="ygaN CDS" gene 865830..866366 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /label="ygaN gene" S_feature 866367..866437 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 866407..866414 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 866428..866447 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 866439 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="upshifts" CDS 866478..866747 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" /label="rpsNB CDS" gene 866478..866747 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /label="rpsNB gene" promotor_-35 866550..866554 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 866577..866593 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 866593 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 866734 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(866765..867238) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" /label="ygaO CDS" gene complement(866765..867238) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /label="ygaO gene" downshifts complement(866801) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(867240..867440) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" /label="ygzD CDS" gene complement(867240..867440) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /label="ygzD gene" promotor_-10 complement(867469..867488) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(867483) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(867501..867508) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 867564..867569 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 867583..867602 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 867583 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="upshifts" tRNA 867634..867707 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gly1 tRNA" gene 867634..867707 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /label="trnSL-Gly1 gene" S_feature 867708..867890 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(867798..868421) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" /label="yhzB CDS" gene complement(867798..868421) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /label="yhzB gene" downshifts complement(867813) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 867847 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature 867892..868503 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(868445..868464) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(868466) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(868478..868485) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 868504..869664 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" /label="queG CDS" gene 868504..869664 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /label="queG gene" downshifts 869673 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 869690..869702 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 869695 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="upshifts" CDS 869731..870666 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" /label="yhbB CDS" gene 869731..870666 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /label="yhbB gene" downshifts complement(869749) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" /label="downshifts" promotor_-35 870650..870653 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 870668 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 870669..870688 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 870704..871186 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" /label="trmL CDS" gene 870704..871186 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /label="trmL gene" downshifts 871169 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 871236..871952 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" /label="yhbD CDS" gene 871236..871952 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /label="yhbD gene" promotor_-35 871256..871263 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 871278..871297 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 871279 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="upshifts" CDS 871943..872656 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" /label="yhbE CDS" gene 871943..872656 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /label="yhbE gene" CDS 872668..873375 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" /label="yhbF CDS" gene 872668..873375 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /label="yhbF gene" downshifts 873259 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 873303 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 873369 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(873402..873577) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(873445) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(873569..873588) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(873577) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(873603..873610) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 873642..873647 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 873663..873681 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 873663 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 873725..875620 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" /label="prkA CDS" gene 873725..875620 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /label="prkA gene" promotor_no_box 874167..874267 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 874227 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 874293 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 875613 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 875677..875682 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 875698..875716 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 875701..875799 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 875701 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 875800..876978 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" /label="yhbH CDS" gene 875800..876978 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /label="yhbH gene" promotor_-35 875998..876001 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 876016..876035 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 876020 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(876261) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" /label="downshifts" downshifts 876957 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 877065..877072 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 877087..877106 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 877087 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 877138..877602 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" /label="yhbI CDS" gene 877138..877602 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /label="yhbI gene" promotor_-35 877427..877433 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 877448..877466 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 877461 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 877611..877617 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 877631..877642 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 877637 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 877638..878303 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" /label="yhbJ CDS" gene 877638..878303 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /label="yhbJ gene" CDS 878344..879942 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" /label="yhcA CDS" gene 878344..879942 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /label="yhcA gene" CDS 879965..880495 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" /label="yhcB CDS" gene 879965..880495 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /label="yhcB gene" CDS 880508..880882 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" /label="yhcC CDS" gene 880508..880882 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /label="yhcC gene" downshifts 880871 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 880882..881037 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" /label="yhcD CDS" gene 880882..881037 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /label="yhcD gene" promotor_-35 880972..880978 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 880993..881012 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 881003 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="upshifts" CDS 881042..881803 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" /label="yhcE CDS" gene 881042..881803 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /label="yhcE gene" promotor_-10 complement(881355..881373) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(881369) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(881389..881394) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 881806..882171 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" /label="yhcF CDS" gene 881806..882171 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /label="yhcF gene" CDS 882173..882871 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" /label="yhcG CDS" gene 882173..882871 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /label="yhcG gene" CDS 882888..883805 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" /label="yhcH CDS" gene 882888..883805 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /label="yhcH gene" CDS 883798..884739 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" /label="yhcI CDS" gene 883798..884739 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /label="yhcI gene" downshifts 884721 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(884831..885034) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" /label="cspB CDS" gene complement(884831..885034) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /label="cspB gene" downshifts complement(884845) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" /label="downshifts" S_feature complement(885035..885162) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 885122..885133 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 885139 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(885151..885170) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(885162) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(885164..886302) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(885184..885189) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 885329..885336 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 885351..885369 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 885358 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 885359..885469 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 885470..886300 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" /label="yhcJ CDS" gene 885470..886300 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /label="yhcJ gene" downshifts 886259 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(886303..887382) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" /label="dgcK CDS" gene complement(886303..887382) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /label="dgcK gene" promotor_-10 complement(887392..887411) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(887413) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="upshifts" promotor_-35 complement(887427..887431) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 887489..887496 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 887510..887529 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 887516 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="upshifts" CDS 887555..888946 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" /label="tcyP CDS" gene 887555..888946 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /label="tcyP gene" S_feature complement(888582..888985) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 888925 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(888986..889441) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" /label="yhcM CDS" gene complement(888986..889441) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /label="yhcM gene" promotor_-10 complement(889456..889474) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(889484) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(889489..889495) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 889533..889539 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 889553..889564 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 889557 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="upshifts" CDS 889591..890160 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" /label="yhcN CDS" gene 889591..890160 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /label="yhcN gene" promotor_-35 889787..889793 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 889804 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 889807..889818 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 890135 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-35 890203..890212 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 890226..890245 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 890236 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="upshifts" CDS 890281..891249 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" /label="yhcO CDS" gene 890281..891249 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /label="yhcO gene" downshifts 891125 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(891181..891834) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " /label="yhcQ CDS" gene complement(891181..891834) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /label="yhcQ gene" downshifts complement(891198) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(891865..891876) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(891867) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(891891..891897) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 891906..891914 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 891917..895570 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" /label="mncR CDS" gene 891917..895570 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /label="mncR gene" promotor_-10 891925..891943 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 891940 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="upshifts" CDS 895567..896163 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" /label="srtA CDS" gene 895567..896163 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /label="srtA gene" downshifts 896142 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(896193..897101) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" /label="yhcT CDS" gene complement(896193..897101) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /label="yhcT gene" promotor_-35 897157..897165 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(897158..897169) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(897164) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(897166..897652) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 897176 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 897179..897198 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(897183..897189) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 897212..897607 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" /label="yhcU CDS" gene 897212..897607 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /label="yhcU gene" misc_feature complement(897638..897657) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(897652) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 897692..897698 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 897707 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 897712..897723 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(897722..897736) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(897736) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(897744..897748) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 897744..898166 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" /label="yhcV CDS" gene 897744..898166 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /label="yhcV gene" promotor_no_box complement(898070..898170) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(898110) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 898144 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(898176) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" promotor_-35 898216..898223 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 898237..898256 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 898245 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="upshifts" CDS 898293..898955 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" /label="glpW CDS" gene 898293..898955 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /label="glpW gene" CDS 898971..900512 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" /label="yhcX CDS" gene 898971..900512 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /label="yhcX gene" downshifts 900495 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" /label="downshifts" CDS 900596..900787 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" /label="yhzG CDS" gene 900596..900787 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo /label="yhzG gene" promotor_-35 900818..900825 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 900840..900859 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 900851..900932 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 900851 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="upshifts" CDS 900933..902285 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" /label="yhxA CDS" gene 900933..902285 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /label="yhxA gene" CDS 902313..902891 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" /label="glpP CDS" gene 902313..902891 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /label="glpP gene" promotor_-35 902886..902893 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 902908..902927 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 902919 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" downshifts 902934 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" /label="downshifts" S_feature 902979..903069 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 903070..903894 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" /label="glpF CDS" gene 903070..903894 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /label="glpF gene" CDS 903913..905403 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" /label="glpK CDS" gene 903913..905403 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /label="glpK gene" promotor_-35 904714..904720 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 904735..904754 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 904745 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="upshifts" S_feature 905404..905492 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 905449 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 905455..905555 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 905515 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" CDS 905544..907211 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" /label="glpD CDS" gene 905544..907211 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /label="glpD gene" promotor_-35 906973..906978 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 906993..907011 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 907002 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="upshifts" promotor_-35 907056..907062 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 907077 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 907078..907096 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 907179 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" /label="downshifts" S_feature 907224..907297 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 907279..907286 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 907299 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 907300..907319 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 907343..909088 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" /label="pgcA CDS" gene 907343..909088 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /label="pgcA gene" downshifts 909077 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" S_feature 909122..909191 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 909193..909212 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 909193 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" CDS 909237..910376 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" /label="yhcY CDS" gene 909237..910376 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /label="yhcY gene" CDS 910373..911017 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" /label="yhcZ CDS" gene 910373..911017 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /label="yhcZ gene" CDS 911014..911538 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" /label="azr CDS" gene 911014..911538 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /label="azr gene" downshifts 911503 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(911553..911795) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" /label="yhdB CDS" gene complement(911553..911795) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /label="yhdB gene" downshifts complement(911574) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(911831..911842) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(911842) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(911856..911863) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 911930..911936 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 911950..911961 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 911960 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="upshifts" CDS 911996..912319 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" /label="yhdC CDS" gene 911996..912319 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /label="yhdC gene" S_feature 912320..914186 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(912361..913827) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" /label="lytF CDS" gene complement(912361..913827) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /label="lytF gene" downshifts complement(912373) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(912460) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(913867..913885) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(913879) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(913899..913906) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(913980..914420) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" /label="nsrR CDS" gene complement(913980..914420) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /label="nsrR gene" downshifts complement(914010) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" promotor_-35 914408..914414 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 914428..914439 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 914430..914540 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 914430 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(914442..914461) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(914458) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(914473..914479) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 914499 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(914527..916185) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" /label="ygxB CDS" gene complement(914527..916185) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /label="ygxB gene" downshifts complement(914532) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(916076..916094) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(916096) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(916108..916114) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 916157..916162 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 916178..916196 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 916191 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="upshifts" CDS 916216..917622 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" /label="spoVR CDS" gene 916216..917622 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /label="spoVR gene" downshifts 917602 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(917652..919037) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" /label="phoA CDS" gene complement(917652..919037) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /label="phoA gene" downshifts complement(917678) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(919064) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(919066..920597) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(919074..919085) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 919193..919200 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 919213..919232 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 919219..919506 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 919219 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 919469..919472 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 919487..919506 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 919508 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="upshifts" CDS 919567..920571 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" /label="lytE CDS" gene 919567..920571 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /label="lytE gene" downshifts 920433 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 920563 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" upshifts complement(920597) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(920604..920619) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 920609 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(920631..920640) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(920642..921517) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" /label="citR CDS" gene complement(920642..921517) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /label="citR gene" promotor_-35 921570..921571 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(921583..921602) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 921588..921607 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(921589) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="upshifts" upshifts 921598 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(921617..921622) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 921626..922726 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" /label="citA CDS" gene 921626..922726 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /label="citA gene" promotor_-35 922737..922743 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 922758..922776 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 922763 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 922800..923669 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" /label="yhdF CDS" gene 922800..923669 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /label="yhdF gene" downshifts 923677 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 923754..923757 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 923769 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 923772..923791 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 923817..923836 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 923822..923918 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 923822 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" CDS 923919..925316 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" /label="bcaP CDS" gene 923919..925316 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /label="bcaP gene" downshifts 925296 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 925377..925381 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 925397..925416 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 925404 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 925434..926789 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" /label="yhdH CDS" gene 925434..926789 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /label="yhdH gene" downshifts 926770 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(926824..928233) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" /label="yhdI CDS" gene complement(926824..928233) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /label="yhdI gene" promotor_-35 928282..928285 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 928300..928319 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 928302 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(928304..928323) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(928316) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(928339..928343) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 928343..928771 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" /label="yhdJ CDS" gene 928343..928771 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /label="yhdJ gene" downshifts 928750 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(928802..929092) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" /label="asiMB CDS" gene complement(928802..929092) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /label="asiMB gene" downshifts complement(928826) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(929080..930156) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" /label="asiMA CDS" gene complement(929080..930156) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /label="asiMA gene" CDS complement(930146..930637) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" /label="sigM CDS" gene complement(930146..930637) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /label="sigM gene" S_feature complement(930638..930740) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(930729..930748) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(930740) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(930762..930765) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 930778..930784 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 930795 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 930799..930817 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(930828) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS 930834..931829 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" /label="akrN CDS" gene 930834..931829 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /label="akrN gene" downshifts 931808 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 931891..931894 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 931909..931928 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 931914 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="upshifts" CDS 931964..932563 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" /label="plsC CDS" gene 931964..932563 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /label="plsC gene" downshifts 932578 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 932623..934577 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(932632..933966) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" /label="yhdP CDS" gene complement(932632..933966) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /label="yhdP gene" downshifts complement(932651) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" CDS complement(934027..934458) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" /label="cueR CDS" gene complement(934027..934458) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /label="cueR gene" promotor_-10 complement(934470..934489) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(934480) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(934504..934510) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(934506..934606) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 934541..934548 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(934546) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 934562..934581 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 934579 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="upshifts" CDS 934615..935796 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" /label="yhdR CDS" gene 934615..935796 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /label="yhdR gene" downshifts 935781 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" /label="downshifts" S_feature 935826..935964 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 935960..935979 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 935966..936122 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 935966 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="upshifts" CDS 936123..937508 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" /label="yhdT CDS" gene 936123..937508 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /label="yhdT gene" downshifts 937398 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 937484 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(937522..937878) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" /label="crcBA CDS" gene complement(937522..937878) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /label="crcBA gene" CDS complement(937875..938270) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" /label="crcBB CDS" gene complement(937875..938270) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /label="crcBB gene" CDS complement(938257..938988) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" /label="yhdW CDS" gene complement(938257..938988) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /label="yhdW gene" misc_feature complement(939013..939032) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(939034) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 939081..939089 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 939098 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 939103..939118 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 939112..939185 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 939172..939173 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 939187 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 939189..939208 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 939222..939329 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" /label="yhdX CDS" gene 939222..939329 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /label="yhdX gene" S_feature 939330..939383 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 939354 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 939434..939453 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 939440 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 939478..940593 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" /label="mscY CDS" gene 939478..940593 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /label="mscY gene" downshifts 940573 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" /label="downshifts" misc_feature 940630..940649 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 940630 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 940663..941406 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" /label="srtN CDS" gene 940663..941406 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /label="srtN gene" downshifts 941378 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(941430..942278) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" /label="yheN CDS" gene complement(941430..942278) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /label="yheN gene" downshifts complement(941454) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 942274..942279 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(942279..942378) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 942295..942313 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 942297 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="upshifts" S_feature 942302..942497 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(942367..942386) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(942381) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(942401..942404) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 942496..942515 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 942499..942562 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 942499 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="upshifts" CDS 942563..943411 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" /label="dat CDS" gene 942563..943411 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /label="dat gene" downshifts 943402 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(943454..944815) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" /label="nhaC CDS" gene complement(943454..944815) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /label="nhaC gene" downshifts complement(943478) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(944816..944886) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(944859..944878) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(944886) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(944942..945442) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" /label="nhaX CDS" gene complement(944942..945442) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /label="nhaX gene" downshifts complement(944974) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(945464..945482) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(945484) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(945497..945503) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 945521..945528 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 945536..945605 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 945537 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 945543..945562 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 945606..945767 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" /label="bmrB CDS" gene 945606..945767 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /label="bmrB gene" downshifts 945697 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" /label="downshifts" S_feature 945768..945886 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 945887..947644 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" /label="bmrC CDS" gene 945887..947644 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /label="bmrC gene" CDS 947641..949662 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" /label="bmrD CDS" gene 947641..949662 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /label="bmrD gene" downshifts 949650 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(949711..950331) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" /label="yheG CDS" gene complement(949711..950331) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /label="yheG gene" downshifts complement(949726) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 950316..950416 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(950345..950364) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(950360) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="upshifts" CDS complement(950370..950495) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" /label="yheF CDS" gene complement(950370..950495) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /label="yheF gene" upshifts 950376 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(950379..950382) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(950509..950528) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(950518) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(950542..950551) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 950574 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(950600..950803) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" /label="sspB CDS" gene complement(950600..950803) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /label="sspB gene" downshifts complement(950605) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(950804..950914) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 950844..950944 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 950904 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(950920) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(950924..950935) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(950950..950956) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(951012..951230) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" /label="yheE CDS" gene complement(951012..951230) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /label="yheE gene" downshifts complement(951046) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(951271..951290) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(951288) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(951304..951311) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(951380..952741) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" /label="spaD CDS" gene complement(951380..952741) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /label="spaD gene" downshifts complement(951398) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(951442) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(952731..953822) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" /label="spaC CDS" gene complement(952731..953822) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /label="spaC gene" promotor_-10 complement(953146..953160) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(953158) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(953174..953182) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(953823..953928) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(953912..953930) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(953932) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(953946..953951) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 953994..954001 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 954016..954035 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 954027 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="upshifts" CDS 954089..955222 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" /label="yheB CDS" gene 954089..955222 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /label="yheB gene" S_feature 955223..955314 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 955315..955668 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" /label="yheA CDS" gene 955315..955668 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /label="yheA gene" downshifts 955656 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(955712..956785) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" /label="yhaZ CDS" gene complement(955712..956785) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /label="yhaZ gene" downshifts complement(955819) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(956807..956826) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(956819) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(956840..956847) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 956922..956929 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 956942 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 956944..956963 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 956953..957106 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 957063 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 957108..957191 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 957148 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" /label="downshifts" promotor_-35 957204..957209 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 957225..957243 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 957234 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 957271..958137 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" /label="yhaX CDS" gene 957271..958137 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /label="yhaX gene" downshifts 958119 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 958182..958185 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 958200..958219 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 958208 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 958249..959754 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" /label="hemZ CDS" gene 958249..959754 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /label="hemZ gene" downshifts 959724 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(959772..960989) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" /label="khtU CDS" gene complement(959772..960989) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /label="khtU gene" downshifts complement(959778) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(960996..961493) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" /label="khtT CDS" gene complement(960996..961493) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /label="khtT gene" CDS complement(961557..961895) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" /label="khtS CDS" gene complement(961557..961895) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /label="khtS gene" promotor_-10 complement(961907..961926) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(961931) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(961940..961947) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 961967..961974 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 961989..962008 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 961999 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="upshifts" CDS 962060..962827 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" /label="yhaR CDS" gene 962060..962827 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /label="yhaR gene" downshifts 962828 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(962848..963033) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" /label="yhzD CDS" gene complement(962848..963033) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /label="yhzD gene" promotor_-10 complement(963069..963087) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(963080) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(963098..963106) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 963107..963110 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 963125..963144 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 963135 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="upshifts" CDS 963160..964056 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" /label="yhaQ CDS" gene 963160..964056 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /label="yhaQ gene" CDS 964049..965308 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" /label="yhaP CDS" gene 964049..965308 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /label="yhaP gene" downshifts 965292 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 965356..965363 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 965375..965394 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 965380 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 965415..966641 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" /label="yhaO CDS" gene 965415..966641 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /label="yhaO gene" downshifts complement(966116) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" /label="downshifts" CDS 966646..969537 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" /label="sbcE CDS" gene 966646..969537 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /label="sbcE gene" promotor_-35 967927..967932 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 967948..967966 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 967954 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 969545..969550 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 969565..969584 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 969580 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 969611..970555 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" /label="yhaM CDS" gene 969611..970555 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /label="yhaM gene" downshifts 970533 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 970614..970619 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 970635..970653 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 970638 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="upshifts" CDS 970680..970892 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" /label="yhaL CDS" gene 970680..970892 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /label="yhaL gene" downshifts 970885 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" /label="downshifts" downshifts complement(970923) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(970933..971811) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" /label="prsA CDS" gene complement(970933..971811) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /label="prsA gene" downshifts complement(971121) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(971849..971868) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(971873) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(971882..971889) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 971909..971918 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 971930 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 971931..971950 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(971967..971981) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(971968) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 971971..972057 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" /label="sscA CDS" gene 971971..972057 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /label="sscA gene" promotor_-35 complement(971990..971994) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 972058..972309 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 972182..972268 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" /label="sscB CDS" gene 972182..972268 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /label="sscB gene" downshifts 972266 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" S_feature complement(972278..972540) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 972311..972794 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(972321) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(972533..972552) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(972540) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(972542..972610) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(972566..972571) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(972611..973129) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" /label="yhaJ CDS" gene complement(972611..973129) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /label="yhaJ gene" promotor_-35 972916..972924 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 972936..972954 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 972949 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(973160..973179) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(973178) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(973195..973201) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 973278..973281 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 973296..973315 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 973301 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="upshifts" CDS 973337..973678 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" /label="yhaI CDS" gene 973337..973678 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /label="yhaI gene" S_feature complement(973532..973674) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(973575) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(973675..974286) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" /label="scoC CDS" gene complement(973675..974286) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /label="scoC gene" S_feature 973679..974444 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(973751) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" promotor_-35 974282..974286 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 974294..974307 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 974306 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(974311..974330) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(974334) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="upshifts" promotor_-35 complement(974345..974348) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 974401 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(974464..974820) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" /label="yhaH CDS" gene complement(974464..974820) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /label="yhaH gene" downshifts complement(974468) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 974897..974902 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(974903..974922) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(974917) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 974918..974936 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 974918 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(974919..975182) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 974950..975141 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" /label="yhzF CDS" gene 974950..975141 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /label="yhzF gene" S_feature 975142..976577 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(975215..975733) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" /label="trpP CDS" gene complement(975215..975733) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /label="trpP gene" downshifts complement(975227) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" /label="downshifts" S_feature complement(975734..975821) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(975813..975832) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(975821) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(975846..975853) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(975858..976937) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" /label="serC CDS" gene complement(975858..976937) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /label="serC gene" misc_feature complement(976976..976995) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(976987) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(976989..977070) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(977084..977521) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" /label="hinT CDS" gene complement(977084..977521) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /label="hinT gene" downshifts complement(977115) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(977554..977573) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(977568) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" downshifts 977571 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(977587..977594) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(977593..977889) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(977636) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(977887..977898) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(977893) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(977913..977919) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 977949..977956 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 977970..977989 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 977979 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="upshifts" CDS 978009..978752 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" /label="ecsA CDS" gene 978009..978752 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /label="ecsA gene" CDS 978745..979971 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" /label="ecsB CDS" gene 978745..979971 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /label="ecsB gene" promotor_-10 complement(979304..979322) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(979319) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(979338..979343) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 979991..980701 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" /label="ecsC CDS" gene 979991..980701 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /label="ecsC gene" downshifts 980665 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(980719..981909) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" /label="sndC CDS" gene complement(980719..981909) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /label="sndC gene" downshifts complement(980729) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(980794) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(981933..981952) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(981954) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(981966..981971) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(981982..983373) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" /label="yhfA CDS" gene complement(981982..983373) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /label="yhfA gene" promotor_-10 complement(983384..983403) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(983389) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(983416..983425) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(983439..983753) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" /label="yhgB CDS" gene complement(983439..983753) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /label="yhgB gene" CDS complement(983798..984298) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" /label="hmoB CDS" gene complement(983798..984298) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /label="hmoB gene" downshifts complement(983825) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(984311..984330) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 984313..984317 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(984332) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 984333..984352 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 984334 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(984347..984348) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 984365..984371 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 984386..984397 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 984391 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="upshifts" CDS 984420..986564 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" /label="pbpF CDS" gene 984420..986564 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /label="pbpF gene" promotor_-10 complement(984464..984475) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(984467) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(984489..984495) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 986601..986607 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 986621..986640 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 986631 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" CDS 986686..987747 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" /label="hemE CDS" gene 986686..987747 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /label="hemE gene" CDS 987819..988751 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" /label="hemH CDS" gene 987819..988751 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /label="hemH gene" CDS 988766..990178 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" /label="hemY CDS" gene 988766..990178 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /label="hemY gene" downshifts 988769 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 990155 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 990239..990246 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 990260..990279 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 990265 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" CDS 990324..990899 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" /label="yhgD CDS" gene 990324..990899 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /label="yhgD gene" promotor_-35 990643..990646 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 990661 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 990663..990682 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 990900..990969 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 990970..993297 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" /label="yhgE CDS" gene 990970..993297 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /label="yhgE gene" downshifts 993279 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(993339..994316) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" /label="fabHB CDS" gene complement(993339..994316) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /label="fabHB gene" downshifts complement(993352) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(994330..994349) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(994348) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(994363..994369) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 994375..994383 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 994394..994412 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 994401 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 994443..995219 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" /label="yhfC CDS" gene 994443..995219 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /label="yhfC gene" S_feature complement(994935..995556) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 995220..995591 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(995534..995553) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(995555) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(995567..995576) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 995569..995576 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 995591..995610 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 995593 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 995632..996672 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" /label="yhfE CDS" gene 995632..996672 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /label="yhfE gene" CDS 996685..997092 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" /label="yhfF CDS" gene 996685..997092 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /label="yhfF gene" downshifts 997063 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(997129..998418) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" /label="gltT CDS" gene complement(997129..998418) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /label="gltT gene" downshifts complement(997159) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(998419..998519) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(998518..998537) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(998519) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(998521..998657) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(998552..998558) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(998689..998829) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" /label="yhfH CDS" gene complement(998689..998829) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /label="yhfH gene" downshifts complement(998702) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(998848..998867) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(998867) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(998880..998887) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 998911..998917 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 998931..998950 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 998934 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="upshifts" CDS 998981..999715 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" /label="yhfI CDS" gene 998981..999715 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /label="yhfI gene" CDS 999728..1000723 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" /label="lplJ CDS" gene 999728..1000723 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /label="lplJ gene" CDS 1000788..1001432 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" /label="yhfK CDS" gene 1000788..1001432 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /label="yhfK gene" downshifts 1001420 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1001460..1001463 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1001478..1001497 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1001485 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="upshifts" CDS 1001549..1003090 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" /label="lcfB CDS" gene 1001549..1003090 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /label="lcfB gene" downshifts 1003070 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1003129..1003524) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388909.1" /db_xref="EnsemblGenomes-Gn:BSU10280" /db_xref="EnsemblGenomes-Tr:CAB12868" /db_xref="SubtiList:BG13058" /db_xref="UniProtKB/Swiss-Prot:O07611" /translation="MKKIVAAIVVIGLVFIAFFYLYSRSGDVYQSVDADLITLSSSGQ EDIEIEKRQHVKDMLDIMNQGKQVKTEKTSAPDYEGTIKFHKDRYDSFRLWIDGSQQA VFLKDGTYYKLSKNDTKALLNIIKKEAKD*" /label="yhfM CDS" gene complement(1003129..1003524) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /label="yhfM gene" downshifts complement(1003146) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1003544..1003555) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1003548) /Source="Nicolas_upshifts" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1003570..1003576) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1003609..1003612 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1003620 /Source="Nicolas_upshifts" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1003627..1003646 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1003673..1004953 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /EC_number="3.4.24.84" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9015299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane metalloprotease" /protein_id="NP_388910.1" /db_xref="EnsemblGenomes-Gn:BSU10290" /db_xref="EnsemblGenomes-Tr:CAB12869" /db_xref="GOA:P40769" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR027057" /db_xref="InterPro:IPR032456" /db_xref="SubtiList:BG11029" /db_xref="UniProtKB/Swiss-Prot:P40769" /translation="MRKWIAAAGLAYVLYGLFFYWYFFLSGDSAIPEAVKGTQADPAS FMKPSELAVAEQYSNVKNFLFFIGVPLDWFLFFVLLVSGVSKKIKKWIEAAVPFRFLQ TVGFVFVLSLITTLVTLPLDWIGYQVSLDYNISTQTTASWAKDQVISFWISFPIFTLC VLVFYWLIKRHEKKWWLYAWLLTVPFSLFLFFIQPVIIDPLYNDFYPLKNKELESKIL ELADEANIPADHVYEVNMSEKTNALNAYVTGIGANKRIVLWDTTLNKLDDSEILFIMG HEMGHYVMKHVYIGLAGYLLVSLAGFYVIDKLYKRTVRLTRSMFHLEGRHDLAALPLL LLLFSVLSFAVTPFSNAVSRYQENKADQYGIELTENREAAVKTFQDLAVTGLSQVDPP VLVKIFRGSHPSIMERIQHAEKEENAPEHQDADK*" /label="yhfN CDS" gene 1003673..1004953 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /label="yhfN gene" promotor_-10 complement(1004100..1004119) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1004114) /Source="Nicolas_upshifts" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1004135..1004140) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1004940 /Source="Nicolas_upshifts" /id="D560" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="3.82026" /MaxDrop="3.6342" /score="6.45541384" /energy="-12.7" /TU="U828" /idTUdmin="U828" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(1004990) /Source="Nicolas_upshifts" /id="D561" /incds=0 /nref=129 /ntot=219 /MaxReadThrough="-0.11848" /MaxDrop="9.02627" /score="-6.76069514" /energy="-7.8" /TU="NA" /idTUdmin="U830" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1004992..1006137) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /EC_number="3.4.21.62" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine alkaline protease (Ca(2+)-dependent subtilisin E)" /protein_id="NP_388911.2" /db_xref="EnsemblGenomes-Gn:BSU10300" /db_xref="EnsemblGenomes-Tr:CAB12870" /db_xref="GOA:P04189" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="PDB:1SCJ" /db_xref="PDB:3WHI" /db_xref="SubtiList:BG10190" /db_xref="UniProtKB/Swiss-Prot:P04189" /translation="MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFK QTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHI AHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSE TNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIE WAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAK YPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVA GAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ*" /label="aprE CDS" gene complement(1004992..1006137) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /label="aprE gene" S_feature complement(1006138..1006204) /Source="Nicolas_S_feature" /locus_tag="new_1105569_1105635_c" /HighExp="BC, T5.0H, LoTm, Sw, T4.0H, T3.30H, S1, T3.0H, S2, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S363" promotor_-10 complement(1006193..1006212) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1006210) /Source="Nicolas_upshifts" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1006228..1006232) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1006517..1006524 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-35" promotor_-10 1006539..1006558 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-10" upshifts 1006541 /Source="Nicolas_upshifts" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="upshifts" CDS 1006572..1007021 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /EC_number="2.3.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388912.1" /db_xref="EnsemblGenomes-Gn:BSU10310" /db_xref="EnsemblGenomes-Tr:CAB12871" /db_xref="GOA:O07614" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13059" /db_xref="UniProtKB/Swiss-Prot:O07614" /translation="MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLEN HESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAK DYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK*" /label="yhfO CDS" gene 1006572..1007021 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /label="yhfO gene" promotor_-35 1007037..1007044 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1007059..1007078 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1007066 /Source="Nicolas_upshifts" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1007093..1008085 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9643546, 12057962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388913.1" /db_xref="EnsemblGenomes-Gn:BSU10320" /db_xref="EnsemblGenomes-Tr:CAB12872" /db_xref="GOA:O07615" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014188" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="PDB:1TT7" /db_xref="PDB:1Y9E" /db_xref="SubtiList:BG13060" /db_xref="UniProtKB/Swiss-Prot:O07615" /translation="MSTLFQALQAEKNADDVSVHVKTISTEDLPKDGVLIKVAYSGIN YKDGLAGKAGGNIVREYPLILGIDAAGTVVSSNDPRFAEGDEVIATSYELGVSRDGGL SEYASVPGDWLVPLPQNLSLKEAMVYGTAGFTAALSVHRLEQNGLSPEKGSVLVTGAT GGVGGIAVSMLNKRGYDVVASTGNREAADYLKQLGASEVISREDVYDGTLKALSKQQW QGAVDPVGGKQLASLLSKIQYGGSVAVSGLTGGGEVPATVYPFILRGVSLLGIDSVYC PMDVRAAVWERMSSDLKPDQLLTIVDREVSLEETPGALKDILQNRIQGRVIVKL*" /label="yhfP CDS" gene 1007093..1008085 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /label="yhfP gene" downshifts 1008086 /Source="Nicolas_upshifts" /id="D562" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="4.4421" /MaxDrop="2.9095" /score="14.183693" /energy="-15.3" /TU="U831,U832" /idTUdmin="U831" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" S_feature 1008131..1008241 /Source="Nicolas_S_feature" /locus_tag="new_1107562_1107672" /HighExp="Etha, dia15, LoTm, Salt, H2O2, LBGexp, Diami, Paraq, dia5, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S364" promotor_-35 1008219..1008226 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1008242..1008261 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1008243 /Source="Nicolas_upshifts" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1008302..1009273 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /translation="MKKTLIILTVLLLSVLTAACSSSSGNQNSKEHKVAVTHDLGKTN VPEHPKRVVVLELGFIDTLLDLGITPVGVADDNKAKQLINKDVLKKIDGYTSVGTRSQ PSMEKIASLKPDLIIADTTRHKKVYDQLKKIAPTIALNNLNADYQDTIDASLTIAKAV GKEKEMEKKLTAHEEKLSETKQKISANSQSVLLIGNTNDTIMARDENFFTSRLLTQVG YRYAISTSGNSDSSNGGDSVNMKMTLEQLLKTDPDVIILMTGKTDDLDADGKRPIEKN VLWKKLKAVKNGHVYHVDRAVWSLRRSVDGANAILDELQKEMPAAKK*" /label="yhfQ CDS" gene 1008302..1009273 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /label="yhfQ gene" downshifts 1009252 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1009305..1009886) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" /label="phoE CDS" gene complement(1009305..1009886) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /label="phoE gene" downshifts complement(1009328) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1009910..1009929) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1009922) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1009945..1009948) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1009957..1011051) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" /label="yhfS CDS" gene complement(1009957..1011051) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /label="yhfS gene" CDS complement(1011048..1012487) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" /label="yhfT CDS" gene complement(1011048..1012487) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /label="yhfT gene" CDS complement(1012494..1013054) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" /label="bioY CDS" gene complement(1012494..1013054) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /label="bioY gene" misc_feature complement(1012504..1012523) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1012518) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1013079..1013098) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1013093) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1013113..1013120) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1013189..1014487) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" /label="hemAT CDS" gene complement(1013189..1014487) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /label="hemAT gene" downshifts complement(1013200) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1014541..1014559) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1014544) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1014573..1014579) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1014626..1016155) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" /label="yhfW CDS" gene complement(1014626..1016155) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /label="yhfW gene" promotor_-10 complement(1016182..1016200) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1016192) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1016211..1016216 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1016215..1016220) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1016228 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1016232..1016250 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1016267..1017124 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" /label="yhxC CDS" gene 1016267..1017124 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /label="yhxC gene" downshifts 1017106 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1017152..1017385) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" /label="yhzC CDS" gene complement(1017152..1017385) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /label="yhzC gene" downshifts complement(1017185) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1017402..1017421) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1017405..1017406 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1017405 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1017409..1017424 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1017424) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1017426..1018281) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(1017436..1017443) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1017608..1017615 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 1017627..1017646 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 1017633 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="upshifts" CDS 1017678..1018256 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 1017678..1018256 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" S_feature 1018257..1018402 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(1018303..1019202) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" /label="yhxD CDS" gene complement(1018303..1019202) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /label="yhxD gene" downshifts complement(1018326) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1018389..1018392 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1018404 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1018410..1018414 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1018448 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1018493..1019359 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(1019229..1019247) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1019246) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1019262..1019268) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1019336..1019343 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1019358..1019377 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1019361 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1019419..1019688 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" /label="yhjA CDS" gene 1019419..1019688 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /label="yhjA gene" downshifts 1019680 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1019728) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1019731..1021200) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" /label="yhjB CDS" gene complement(1019731..1021200) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /label="yhjB gene" CDS complement(1021197..1021397) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" /label="yhjC CDS" gene complement(1021197..1021397) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /label="yhjC gene" S_feature complement(1021398..1021516) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(1021499..1021518) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1021516) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1021531..1021538) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1021604) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(1021605..1021967) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" /label="yhjD CDS" gene complement(1021605..1021967) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /label="yhjD gene" promotor_-35 1021805..1021810 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1021826..1021844 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1021827 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1021836..1022075 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(1021997..1022016) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1022015) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1022031..1022038) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1022057..1022064 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1022077 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1022078..1022097 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1022119..1022742 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" /label="yhjE CDS" gene 1022119..1022742 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /label="yhjE gene" CDS 1022744..1023250 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" /label="sipV CDS" gene 1022744..1023250 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /label="sipV gene" downshifts 1023243 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1023301..1023308 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1023322..1023341 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1023331..1023430 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 1023331 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="upshifts" CDS 1023431..1024930 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" /label="yhjG CDS" gene 1023431..1024930 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /label="yhjG gene" promotor_-35 1024938..1024945 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1024957 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1024959..1024978 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1025007..1025534 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" /label="yhjH CDS" gene 1025007..1025534 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /label="yhjH gene" downshifts 1025496 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" /label="downshifts" S_feature complement(1025548..>1025568) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" SCAR join(1025568,1025584) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" N_region 1025569..1025583 /note="inserted sequence possibly derived from two restrictions with NotI and SacI" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" S_feature <1025584..1025870 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(<1025584..1025705) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(1025590) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1025706..1026860) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" /label="yhjN CDS" gene complement(1025706..1026860) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /label="yhjN gene" S_feature complement(1026861..1026932) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(1026915..1026934) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1026931) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1026948..1026953) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1026967..1028172) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" /label="yhjO CDS" gene complement(1026967..1028172) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /label="yhjO gene" misc_feature 1028193..1028212 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1028198 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1028286..1030013 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" /label="yhjP CDS" gene 1028286..1030013 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /label="yhjP gene" promotor_-35 1029599..1029606 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1029621..1029640 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1029628 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1030043..1030369) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" /label="yhjQ CDS" gene complement(1030043..1030369) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /label="yhjQ gene" CDS complement(1030487..1030924) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" /label="yhjR CDS" gene complement(1030487..1030924) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /label="yhjR gene" downshifts complement(1030496) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1030955..1030974) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1030975) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1030987..1030996) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1031044..1031051 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1031065..1031084 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1031077 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="upshifts" CDS 1031108..1034608 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" /label="addB CDS" gene 1031108..1034608 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /label="addB gene" CDS 1034595..1038293 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" /label="addA CDS" gene 1034595..1038293 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /label="addA gene" S_feature 1038294..1038364 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 1038365..1039540 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " /label="sbcD CDS" gene 1038365..1039540 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /label="sbcD gene" CDS 1039537..1042929 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" /label="sbcC CDS" gene 1039537..1042929 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /label="sbcC gene" promotor_-35 1042184..1042190 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1042205..1042216 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1042212 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1042281..1043254) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 1042943..1043245 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" /label="hlpB CDS" gene 1042943..1043245 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /label="hlpB gene" downshifts 1043225 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" /label="downshifts" downshifts complement(1043299) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" /label="downshifts" SCAR 1043303..1043304 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27_007" downshifts 1043323 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1043362..1043949) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" /label="yisN CDS" gene complement(1043362..1043949) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /label="yisN gene" promotor_-10 complement(1043964..1043983) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1043983) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1043999..1044001) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1044004..1044010 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1044022 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1044025..1044043 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1044028..1044094 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 1044095..1045939 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" /label="asnO CDS" gene 1044095..1045939 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /label="asnO gene" S_feature 1045940..1046007 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 1045964 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1046069..1046548) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " /label="yizA CDS" gene complement(1046069..1046548) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /label="yizA gene" upshifts complement(1046568) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1046572..1046590) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1046601..1046609) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1046740..1046744 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1046757 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1046759..1046778 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1046780..1047604 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" /label="farP CDS" gene 1046780..1047604 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /label="farP gene" promotor_-35 1046992..1046998 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1047013..1047031 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1047020 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1047614..1049064 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(1047634..1049001) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" /label="yisQ CDS" gene complement(1047634..1049001) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /label="yisQ gene" promotor_-35 1049033..1049040 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1049054..1049073 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1049066 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="upshifts" CDS 1049125..1049988 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" /label="yisR CDS" gene 1049125..1049988 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /label="yisR gene" CDS 1050006..1051019 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" /label="iolQ CDS" gene 1050006..1051019 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /label="iolQ gene" downshifts 1051002 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-35 1051071..1051078 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1051093..1051112 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1051112..1051227 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 1051112 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="upshifts" CDS 1051228..1052256 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" /label="iolX CDS" gene 1051228..1052256 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /label="iolX gene" downshifts 1052278 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1052307..1052816) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" /label="yisT CDS" gene complement(1052307..1052816) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /label="yisT gene" downshifts complement(1052326) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1052829..1052847) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1052845) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1052859..1052867) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1052866..1053528) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" /label="yisU CDS" gene complement(1052866..1053528) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /label="yisU gene" promotor_-35 1053547..1053553 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1053567..1053586 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1053576 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="upshifts" CDS 1053595..1055049 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" /label="yisV CDS" gene 1053595..1055049 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /label="yisV gene" S_feature complement(1054904..1055056) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(1054939) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1055057..1055695) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" /label="yisX CDS" gene complement(1055057..1055695) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /label="yisX gene" S_feature complement(1055696..1055830) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 1055744..1055749 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1055765..1055783 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1055766 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="upshifts" S_feature 1055776..1055900 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(1055816..1055835) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1055830) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1055850..1055857) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1055901..1056707 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" /label="yisY CDS" gene 1055901..1056707 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /label="yisY gene" downshifts 1056700 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1056735..1057334) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" /label="yisZ CDS" gene complement(1056735..1057334) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /label="yisZ gene" downshifts complement(1056754) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1057331..1058500) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" /label="yitA CDS" gene complement(1057331..1058500) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /label="yitA gene" S_feature complement(1058501..1058612) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(1058613..1059323) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" /label="yitB CDS" gene complement(1058613..1059323) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /label="yitB gene" promotor_-10 complement(1059367..1059386) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1059389) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1059399..1059408) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1059438..1059447 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1059461..1059480 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1059472 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="upshifts" CDS 1059508..1060194 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" /label="slpH CDS" gene 1059508..1060194 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /label="slpH gene" CDS 1060191..1060949 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" /label="slpS CDS" gene 1060191..1060949 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /label="slpS gene" downshifts 1060946 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1060994..1061623) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" /label="yitE CDS" gene complement(1060994..1061623) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /label="yitE gene" promotor_-10 complement(1061657..1061675) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1061674) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1061690..1061695) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1061719..1062834) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" /label="yitF CDS" gene complement(1061719..1062834) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /label="yitF gene" downshifts complement(1061748) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1062843..1064111) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" /label="yitG CDS" gene complement(1062843..1064111) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /label="yitG gene" promotor_-10 complement(1064137..1064148) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1064146) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1064162..1064168) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1064223..1065071) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" /label="yitH CDS" gene complement(1064223..1065071) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /label="yitH gene" downshifts complement(1064234) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1065076..1065525) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" /label="yitI CDS" gene complement(1065076..1065525) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /label="yitI gene" promotor_-10 complement(1065546..1065565) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1065560) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1065581..1065582) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1065615..1067453) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" /label="samT CDS" gene complement(1065615..1067453) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /label="samT gene" downshifts complement(1065642) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts complement(1067535) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1067543..1067660) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswK RNA" gene complement(1067543..1067660) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /label="mswK gene" promotor_-10 complement(1067712..1067731) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(1067726) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1067746..1067753) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(1067767..1068258) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" /label="yitK CDS" gene complement(1067767..1068258) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /label="yitK gene" promotor_-35 1068276..1068279 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1068282..1068301) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 1068294..1068313 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1068295 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1068300) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1068316..1068323) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 1068357..1069253 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" /label="yitL CDS" gene 1068357..1069253 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /label="yitL gene" downshifts 1069240 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1069316) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 1069328..1069329 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_016" S_feature <1069329..1069382 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" promotor_-10 complement(<1069329..1069343) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1069347) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1069361..1069366 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1069381..1069399 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1069384 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" CDS 1069421..1070263 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" /label="yitT CDS" gene 1069421..1070263 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /label="yitT gene" promotor_-35 1069916..1069924 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1069935..1069953 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1069935 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="upshifts" S_feature 1070264..1070377 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 1070378..1070737 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" /label="ipi CDS" gene 1070378..1070737 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /label="ipi gene" downshifts 1070726 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1070768..1070965) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" /label="yizC CDS" gene complement(1070768..1070965) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /label="yizC gene" downshifts complement(1070781) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1070966..1071162) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(1071162) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1071164..1071175) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1071190..1071196) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1071222..1072034) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" /label="ribZC CDS" gene complement(1071222..1072034) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /label="ribZC gene" promotor_-10 complement(1072072..1072091) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1072092..1072099 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1072092) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1072105..1072112) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1072111..1072130 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1072113 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1072155..1072922 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" /label="yitV CDS" gene 1072155..1072922 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /label="yitV gene" promotor_-35 1072931..1072937 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1072951 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1072952..1072971 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1072986..1073294 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" /label="yitW CDS" gene 1072986..1073294 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /label="yitW gene" downshifts 1073279 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" /label="downshifts" S_feature 1073324..1073589 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 1073590..1075020 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" /label="yitY CDS" gene 1073590..1075020 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /label="yitY gene" CDS 1075065..1075559 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" /label="yitZ CDS" gene 1075065..1075559 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /label="yitZ gene" downshifts 1075523 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1075697..1075704 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1075703 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1075718..1075737 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1075766..1076803 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" /label="argC CDS" gene 1075766..1076803 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /label="argC gene" CDS 1076823..1078043 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" /label="argJ CDS" gene 1076823..1078043 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /label="argJ gene" CDS 1078058..1078834 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" /label="argB CDS" gene 1078058..1078834 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /label="argB gene" CDS 1078831..1079988 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" /label="argD CDS" gene 1078831..1079988 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /label="argD gene" CDS 1080059..1081114 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /modified_by="User" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGLSNGPGDPKAIQPY LGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMTSQ NHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEWIF DDYLKNVIPARREIAHA*" /label="Delta6_BSU_11230_SNPvariant" gene 1080059..1081114 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /modified_by="User" /label="Delta6_BSU_11230_SNPvariant" Polymorphism join(1080669,1080670) /Source="geneious" /ID="SNP_BsDelta6_1199938_1199943" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=6 /Amino_Acid_Change="GIV -> G" /CDS_Position=612 /Change="-AATTGT" /Codon_Change="GGA,ATT,GTG -> GGG" /Coverage="183 -> 185" /locus_tag="BSU_11230" /Protein_Effect="Deletion" /Reference_Frequency /Reference_Nucleotides="AATTGT" /Variant_Nucleotides /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="Delta6_BSU_11230_SNPvariant" / /modified_by="User" /label="Polymorphism_Delta6" misc_feature complement(1080948..1080967) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1080958) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1081107..1084199 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" /label="carB CDS" gene 1081107..1084199 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /label="carB gene" CDS 1084187..1085146 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" /label="argF CDS" gene 1084187..1085146 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /label="argF gene" downshifts 1085109 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" /label="downshifts" S_feature complement(1085149..1085423) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 1085174..1085180 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1085182) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 1085195..1085206 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1085216 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="upshifts" CDS 1085232..1085411 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" /label="yjzC CDS" gene 1085232..1085411 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /label="yjzC gene" downshifts 1085421 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1085457..1085642) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" /label="yjzD CDS" gene complement(1085457..1085642) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /label="yjzD gene" downshifts complement(1085468) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1085671..1085690) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1085688) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1085701..1085708) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1085743..1085749 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1085761..1085780 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1085766 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1085823..1085832 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1085832 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1085845..1085864 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1085891..1086625 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" /label="yjaU CDS" gene 1085891..1086625 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /label="yjaU gene" S_feature complement(1086384..1086986) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 1086606..1086611 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1086624 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" /label="downshifts" upshifts 1086624 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1086627..1086645 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1086707..1087264 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" /label="yjaV CDS" gene 1086707..1087264 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /label="yjaV gene" promotor_-10 complement(1086966..1086985) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1086986) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1087000..1087004) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1087271..1087278 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1087293..1087312 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1087305 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1087355..1088308 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" /label="med CDS" gene 1087355..1088308 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /label="med gene" promotor_-35 1087972..1087976 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1087992..1088011 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1088005 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1088323..1088514 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" /label="comZ CDS" gene 1088323..1088514 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /label="comZ gene" downshifts 1088493 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1088538..1088878 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(1088544..1088783) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" /label="yjzB CDS" gene complement(1088544..1088783) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /label="yjzB gene" downshifts complement(1088560) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1088796..1088815) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1088817) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1088829..1088838) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1088844..1088851 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1088866..1088885 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1088880 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="upshifts" CDS 1088948..1089886 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" /label="fabHA CDS" gene 1088948..1089886 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /label="fabHA gene" promotor_-35 1089025..1089034 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1089043 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1089046..1089061 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1089909..1091150 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" /label="fabF CDS" gene 1089909..1091150 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /label="fabF gene" promotor_-10 complement(1090123..1090141) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1090131) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1090157..1090162) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1091001 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 1091134 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 1091175..1091184 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 1091197..1091216 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 1091199 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="upshifts" promotor_-35 1091211..1091219 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1091226..1092011 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" /label="yjaZ CDS" gene 1091226..1092011 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /label="yjaZ gene" promotor_-10 1091231..1091249 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1091243 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1092012..1092096 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(1092028..1092046) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1092045) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1092061..1092066) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1092064..1092071 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1092086..1092105 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1092098..1092202 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 1092098 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1092203..1093189 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" /label="appD CDS" gene 1092203..1093189 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /label="appD gene" CDS 1093186..1094175 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" /label="appF CDS" gene 1093186..1094175 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /label="appF gene" misc_feature 1094181..1094187 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1094186..1094262 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1094186 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1094263..1094754 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" /label="appAn CDS" gene 1094263..1094754 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo /label="appAn gene" CDS 1094727..1095893 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" /label="appAc CDS" gene 1094727..1095893 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo /label="appAc gene" downshifts 1095884 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" /label="downshifts" CDS 1095969..1096919 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" /label="appB CDS" gene 1095969..1096919 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /label="appB gene" CDS 1096936..1097847 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" /label="appC CDS" gene 1096936..1097847 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /label="appC gene" downshifts 1097861 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" S_feature 1097906..1098013 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1097986..1097991 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1098007..1098025 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1098015 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1098052..1098804 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" /label="yjbA CDS" gene 1098052..1098804 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /label="yjbA gene" downshifts 1098784 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1098839..1099831) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" /label="trpS CDS" gene complement(1098839..1099831) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /label="trpS gene" downshifts complement(1098860) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" misc_RNA complement(1099890..1100104) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboWA RNA" gene complement(1099890..1100104) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /label="tboWA gene" downshifts complement(1099938) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" misc_feature complement(1100123..1100142) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1100136) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1100391..1100398 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1100412..1100574 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1100413..1100432 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1100413 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1100575..1102212 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" /label="oppA CDS" gene 1100575..1102212 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /label="oppA gene" downshifts 1102106 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 1102213..1102319 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1102320..1103255 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" /label="oppB CDS" gene 1102320..1103255 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /label="oppB gene" promotor_-10 complement(1102363..1102382) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1102380) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1102398..1102404) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1103259..1104176 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" /label="oppC CDS" gene 1103259..1104176 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /label="oppC gene" CDS 1104181..1105257 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" /label="oppD CDS" gene 1104181..1105257 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /label="oppD gene" CDS 1105259..1106176 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" /label="oppF CDS" gene 1105259..1106176 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /label="oppF gene" downshifts 1106146 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 1106226..1106229 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1106242 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1106244..1106263 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1106283..1107500 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" /label="yjbB CDS" gene 1106283..1107500 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /label="yjbB gene" promotor_-35 1107553..1107562 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1107575..1107590 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1107584..1107663 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1107584 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="upshifts" CDS 1107664..1108242 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" /label="yjbC CDS" gene 1107664..1108242 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /label="yjbC gene" S_feature 1108243..1108357 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1108294..1108313) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1108298) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1108327..1108334) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1108360..1108373 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1108360 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="upshifts" CDS 1108423..1108818 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" /label="spxA CDS" gene 1108423..1108818 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /label="spxA gene" promotor_no_box complement(1108654..1108754) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1108694) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1108816 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1108861..1109650 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1108861..1109517) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" /label="yjbE CDS" gene complement(1108861..1109517) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /label="yjbE gene" promotor_-10 complement(1109547..1109565) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1109562) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1109580..1109585) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1109623..1109630 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1109644..1109663 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1109652..1109793 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1109652 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="upshifts" CDS 1109687..1109827 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" /label="conserved hypothetical protein CDS" gene 1109687..1109827 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /label="gene" CDS 1109794..1110450 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" /label="mecA CDS" gene 1109794..1110450 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /label="mecA gene" downshifts 1110440 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" /label="downshifts" CDS complement(1110445..1110567) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" /label="conserved hypothetical protein CDS" gene complement(1110445..1110567) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /label="gene" S_feature 1110485..1110574 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1110553..1110561 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1110572..1110590 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1110576..1110640 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1110576 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1110641..1111762 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" /label="coiA CDS" gene 1110641..1111762 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /label="coiA gene" promotor_-35 1111416..1111422 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1111434 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-10 1111437..1111455 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1111648..1111656 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1111668..1111686 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1111675 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-35 1111756..1111762 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1111777..1111788 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1111786 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1111809..1113821 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" /label="pepF CDS" gene 1111809..1113821 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /label="pepF gene" promotor_-35 1111884..1111891 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1111906..1111925 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1111918 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="upshifts" downshifts 1113768 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 1113822..1114123 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1113859..1114026) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" /label="yizD CDS" gene complement(1113859..1114026) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /label="yizD gene" downshifts complement(1113872) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1114046..1114064) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1114062) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1114080..1114085) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1114116..1114123 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1114125..1114250 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1114125 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1114131..1114269 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" /label="roxS RNA" gene 1114131..1114269 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /label="roxS gene" promotor_-10 1114138..1114157 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1114207 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" /label="downshifts" CDS complement(1114340..1115239) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" /label="spxH CDS" gene complement(1114340..1115239) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /label="spxH gene" downshifts complement(1114371) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1114575..1114580 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1114587 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1114596..1114614 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1114603..1116504 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1115236..1115634) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" /label="yjbI CDS" gene complement(1115236..1115634) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /label="yjbI gene" S_feature complement(1115635..1115814) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1115806..1115825) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1115814) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1115837..1115844) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1115889..1116434) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" /label="cwlQ CDS" gene complement(1115889..1116434) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /label="cwlQ gene" downshifts complement(1115913) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" S_feature complement(1116435..1116637) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1116638..1117210) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" /label="yjbK CDS" gene complement(1116638..1117210) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /label="yjbK gene" promotor_-10 complement(1116783..1116801) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1116792) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 complement(1116814..1116821) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1117239..1117258) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1117256) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 1117272..1117275 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1117273..1117280) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1117288 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1117291..1117310 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1117335..1117703 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" /label="yjbL CDS" gene 1117335..1117703 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /label="yjbL gene" CDS 1117732..1118367 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" /label="relP CDS" gene 1117732..1118367 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /label="relP gene" CDS 1118386..1119186 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" /label="ppnKA CDS" gene 1118386..1119186 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /label="ppnKA gene" CDS 1119249..1120100 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" /label="yjbO CDS" gene 1119249..1120100 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /label="yjbO gene" downshifts 1120059 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1120113..1120847) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" /label="prpE CDS" gene complement(1120113..1120847) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /label="prpE gene" downshifts complement(1120135) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" promotor_-35 1120969..1120973 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1120990..1121009 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1121004 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="upshifts" S_feature 1121005..1121081 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1121082..1122926 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" /label="kefQ CDS" gene 1121082..1122926 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /label="kefQ gene" misc_feature complement(1121409..1121428) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1121433) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1122928..1122935 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1122949..1122968 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1122955 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="upshifts" misc_RNA 1122988..1123096 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswA RNA" gene 1122988..1123096 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /label="tswA gene" downshifts 1123091 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS 1123175..1123885 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" /label="tenA CDS" gene 1123175..1123885 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /label="tenA gene" CDS 1123860..1124477 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" /label="tenI CDS" gene 1123860..1124477 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /label="tenI gene" CDS 1124461..1125570 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" /label="thiO CDS" gene 1124461..1125570 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /label="thiO gene" CDS 1125570..1125770 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" /label="thiS CDS" gene 1125570..1125770 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /label="thiS gene" CDS 1125767..1126537 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" /label="thiG CDS" gene 1125767..1126537 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /label="thiG gene" CDS 1126534..1127544 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" /label="thiF CDS" gene 1126534..1127544 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /label="thiF gene" CDS 1127563..1128378 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" /label="thiD CDS" gene 1127563..1128378 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /label="thiD gene" downshifts 1128352 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1128425..1128431 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1128444..1128463 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1128454 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="upshifts" CDS 1128514..1129290 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" /label="fabI CDS" gene 1128514..1129290 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /label="fabI gene" downshifts 1129279 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" /label="downshifts" SCAR 1129294..1129295 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_009" S_feature <1129295..1130355 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1129299..1131578) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" /label="yjcD CDS" gene complement(1129299..1131578) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /label="yjcD gene" downshifts complement(1129317) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1131453..1131627) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1131506..1131514 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1131525..1131543 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1131529..1131664 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1131529 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1131615..1131634) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1131626) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1131642..1131648 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1131650..1131654) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1131663..1131681 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1131666 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1131695..1131949 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" /label="yjzE CDS" gene 1131695..1131949 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /label="yjzE gene" downshifts 1131925 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1132015) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" /label="downshifts" CDS complement(1132022..1132444) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" /label="yjcF CDS" gene complement(1132022..1132444) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /label="yjcF gene" CDS complement(1132448..1132963) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" /label="yjcG CDS" gene complement(1132448..1132963) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /label="yjcG gene" CDS complement(1133000..1133722) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" /label="yjcH CDS" gene complement(1133000..1133722) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /label="yjcH gene" misc_feature complement(1133761..1133780) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1133782) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1133831..1133838 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1133853..1133872 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1133857 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1133890..1134010 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswA RNA" gene 1133890..1134010 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /label="mswA gene" downshifts 1134015 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" CDS 1134078..1135199 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" /label="metI CDS" gene 1134078..1135199 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /label="metI gene" CDS 1135192..1136364 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" /label="metC CDS" gene 1135192..1136364 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /label="metC gene" downshifts 1136347 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" misc_feature 1136381..1136399 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1136391 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="upshifts" S_feature 1136392..1137921 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1136397..1136942) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" /label="yjcK CDS" gene complement(1136397..1136942) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /label="yjcK gene" downshifts complement(1136418) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1137012..1138202) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" /label="yjcL CDS" gene complement(1137012..1138202) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /label="yjcL gene" promotor_-10 complement(1138228..1138247) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1138232) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1138262..1138269) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1138296..1138303 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1138307 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1138317..1138336 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1138375..1138447 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val2 tRNA" gene 1138375..1138447 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /label="trnSL-Val2 gene" promotor_-10 complement(1138389..1138406) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1138403) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1138427..1138433) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1138437 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" /label="downshifts" S_feature complement(1138462..1139197) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1138482..1140130 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1138491) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1139199..1139287) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1139242) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" /label="downshifts" CDS complement(1139288..1140517) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" /label="yjcM CDS" gene complement(1139288..1140517) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /label="yjcM gene" downshifts complement(1139410) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" /label="downshifts" downshifts 1140087 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1140518..1140603) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1140558..1140565 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1140580..1140599 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1140589..1140608) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1140593 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1140607) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1140621..1140627) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1140643..1140963 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" /label="yjcN CDS" gene 1140643..1140963 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /label="yjcN gene" downshifts 1140973 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" /label="downshifts" S_feature 1141018..1141115 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1141116..1141247 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " /label="yjzF CDS" gene 1141116..1141247 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /label="yjzF gene" CDS 1141263..1141436 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" /label="yjzG CDS" gene 1141263..1141436 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /label="yjzG gene" CDS 1141473..1141934 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" /label="yjcO CDS" gene 1141473..1141934 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /label="yjcO gene" promotor_-35 1141905..1141912 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1141927..1141946 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1141935..1142175 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1141935 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="upshifts" promotor_-35 1142148..1142155 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1142169..1142187 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1142177 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1142200..1142703 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" /label="yjcP CDS" gene 1142200..1142703 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /label="yjcP gene" CDS 1142715..1142999 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" /label="yjcQ CDS" gene 1142715..1142999 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /label="yjcQ gene" downshifts 1142969 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1143001) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1143012..1143015) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1143160..1143687 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" /label="yjcR CDS" gene 1143160..1143687 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /label="yjcR gene" promotor_-35 1143834..1143839 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1143852..1143871 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1143855 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="upshifts" CDS 1143861..1144178 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" /label="yjcS CDS" gene 1143861..1144178 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /label="yjcS gene" S_feature 1144179..1144414 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1144415..1145170 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" /label="yjdA CDS" gene 1144415..1145170 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /label="yjdA gene" S_feature 1145171..1145258 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1145215 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(1145258..1145318) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1145289) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1145319..1145666) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" /label="yjdB CDS" gene complement(1145319..1145666) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /label="yjdB gene" promotor_-10 complement(1145698..1145716) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1145711) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1145713..1146169) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1145727..1145735) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1146129..1146147 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1146141 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="upshifts" promotor_-10 complement(1146147..1146166) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1146169) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1146180..1146187) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1146217..1148163 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" /label="manR CDS" gene 1146217..1148163 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /label="manR gene" downshifts 1148139 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" SCAR 1148193..1148194 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs02" S_feature <1148194..1148292 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1148267..1148273 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1148288..1148307 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1148294..1148362 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1148294 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="upshifts" CDS 1148363..1148845 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" /label="yjdF CDS" gene 1148363..1148845 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /label="yjdF gene" downshifts 1148825 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1148891..1149397) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" /label="yjdG CDS" gene complement(1148891..1149397) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /label="yjdG gene" downshifts complement(1148915) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" /label="downshifts" misc_feature complement(1149422..1149441) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1149428) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1149430..1149615) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1149616..1150011) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" /label="yjdH CDS" gene complement(1149616..1150011) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /label="yjdH gene" promotor_-10 complement(1150034..1150052) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1150047) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1150049..1150749) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1150067..1150072) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1150155..1150162 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1150176..1150195 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1150187 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="upshifts" CDS 1150240..1150719 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " /label="trnE CDS" gene 1150240..1150719 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /label="trnE gene" downshifts 1150718 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1150759..1150953) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" /label="yjzH CDS" gene complement(1150759..1150953) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /label="yjzH gene" downshifts complement(1150794) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1150967..1150982) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1150983) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1150994..1151003) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1151119..1151448) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" /label="yjdJ CDS" gene complement(1151119..1151448) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /label="yjdJ gene" promotor_-10 complement(1151485..1151504) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1151498) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1151500..1152067) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1151519..1151524) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1151552..1151556 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1151572..1151591 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1151576..1152077 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1151576 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1152068..1153057) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" /label="ctaO CDS" gene complement(1152068..1153057) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /label="ctaO gene" promotor_-10 complement(1153058..1153077) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1153061) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="upshifts" promotor_-35 complement(1153091..1153096) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1153180..1153428) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" /label="cotT CDS" gene complement(1153180..1153428) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /label="cotT gene" downshifts complement(1153190) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1153424..1153428 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1153437..1153451 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1153446 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1153453..1153472) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1153462) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1153486..1153495) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1153543..1153550 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1153557..1153576) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1153564..1153583 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1153566) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="upshifts" upshifts 1153577 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1153578..1153681 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1153590..1153597) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1153682..1155085 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" /label="pdaC CDS" gene 1153682..1155085 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /label="pdaC gene" downshifts 1155074 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1155125..1155598) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" /label="yjfA CDS" gene complement(1155125..1155598) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /label="yjfA gene" downshifts complement(1155129) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1155620..1155638) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1155638) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1155653..1155658) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1155723..1155890) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" /label="yjfB CDS" gene complement(1155723..1155890) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /label="yjfB gene" downshifts complement(1155726) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1155902..1155920) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1155911) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1155933..1155940) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1156017..1156916 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" /label="yjfC CDS" gene 1156017..1156916 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /label="yjfC gene" CDS complement(1156925..1157323) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" /label="yjgA CDS" gene complement(1156925..1157323) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /label="yjgA gene" downshifts complement(1156955) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1157352..1157371) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1157371) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1157386..1157393) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1157424..1157999) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" /label="yjgB CDS" gene complement(1157424..1157999) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /label="yjgB gene" downshifts complement(1157439) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1158018..1158036) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1158033) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1158050..1158056) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1158074..1158080 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1158095..1158113 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1158096 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="upshifts" CDS 1158145..1161102 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" /label="yjgC CDS" gene 1158145..1161102 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /label="yjgC gene" CDS 1161095..1161655 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" /label="yjgD CDS" gene 1161095..1161655 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /label="yjgD gene" downshifts 1161648 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" /label="downshifts" S_feature 1161693..1161811 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1161789..1161792 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1161808..1161827 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1161813 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1161852..1162493 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" /label="yjhA CDS" gene 1161852..1162493 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /label="yjhA gene" downshifts complement(1161861) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" /label="downshifts" downshifts 1162466 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 1162572..1163198 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" /label="yjhB CDS" gene 1162572..1163198 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /label="yjhB gene" downshifts 1163200 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" /label="downshifts" downshifts complement(1163203) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(1163229..1163507) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" /label="yjiA CDS" gene complement(1163229..1163507) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /label="yjiA gene" downshifts complement(1163247) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1163536..1163547) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1163549..1163555) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1163555) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1163557..1163973) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1163725 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1163726..1163745 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1163743..1163897 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1163898..1165088 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" /label="cypE CDS" gene 1163898..1165088 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /label="cypE gene" promotor_-10 complement(1163971..1163990) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1163973) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1164004..1164013) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1165111..1166289 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" /label="ppuG CDS" gene 1165111..1166289 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /label="ppuG gene" CDS complement(1166330..1166518) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" /label="yjzI CDS" gene complement(1166330..1166518) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /label="yjzI gene" downshifts complement(1166346) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1166544..1166563) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1166547) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1166577..1166583) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1166605..1166612 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1166627..1166646 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1166638 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1166653..1166672) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1166657) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1166687..1166694) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1166692..1167504 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" /label="yjjA CDS" gene 1166692..1167504 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /label="yjjA gene" downshifts 1167483 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1167550..1168302) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" /label="yjkA CDS" gene complement(1167550..1168302) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /label="yjkA gene" downshifts complement(1167559) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" /label="downshifts" CDS complement(1168302..1169054) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" /label="yjkB CDS" gene complement(1168302..1169054) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /label="yjkB gene" CDS complement(1169174..1170148) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" /label="yjlA CDS" gene complement(1169174..1170148) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /label="yjlA gene" downshifts complement(1169209) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1170169..1170188) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1170195) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1170197..1172703) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1170203..1170210) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1170231..1170237 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1170252..1170270 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1170255 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1170280..1170777 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" /label="yjlB CDS" gene 1170280..1170777 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /label="yjlB gene" S_feature 1170778..1170891 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1170871..1170875 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1170891..1170910 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1170893..1171165 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1170893 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1171166..1171588 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" /label="yjlC CDS" gene 1171166..1171588 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /label="yjlC gene" CDS 1171628..1172806 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" /label="ndh CDS" gene 1171628..1172806 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /label="ndh gene" promotor_no_box 1172637..1172737 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1172695..1172713) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1172697 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1172703) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1172725..1172733) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1172805 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 1172914..1172921 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1172936..1172955 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1172961 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="upshifts" CDS 1173004..1174425 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" /label="uxaC CDS" gene 1173004..1174425 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /label="uxaC gene" CDS 1174493..1175872 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" /label="exuM CDS" gene 1174493..1175872 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /label="exuM gene" promotor_-10 complement(1175012..1175031) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1175017) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1175045..1175052) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1175897 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1175907..1175914 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1175909..1175976 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1175977..1176990 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" /label="yjmC CDS" gene 1175977..1176990 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /label="yjmC gene" CDS 1176996..1178015 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" /label="yjmD CDS" gene 1176996..1178015 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /label="yjmD gene" CDS 1178040..1179119 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" /label="uxuA CDS" gene 1178040..1179119 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /label="uxuA gene" CDS 1179116..1179952 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" /label="uxuB CDS" gene 1179116..1179952 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /label="uxuB gene" CDS 1180000..1181268 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" /label="exuT CDS" gene 1180000..1181268 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /label="exuT gene" promotor_-35 1181212..1181215 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1181231..1181235 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1181233 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1181301..1181320 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1181301 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" CDS 1181356..1182357 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " /label="exuR CDS" gene 1181356..1182357 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /label="exuR gene" promotor_no_box complement(1182039..1182139) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1182079) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1182333 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1182434..1183876 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" /label="uxaB CDS" gene 1182434..1183876 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /label="uxaB gene" CDS 1183873..1185366 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" /label="uxaA CDS" gene 1183873..1185366 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /label="uxaA gene" CDS complement(1185405..1186169) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /modified_by="User" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGGIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" /label="Delta6_BSU_12400_SNPvariant" gene complement(1185405..1186169) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /modified_by="User" /label="Delta6_BSU_12400_SNPvariant" downshifts complement(1185424) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" Polymorphism join(1185937,1185939) /Source="geneious" /ID="SNP_BsDelta6_1313384_1313384" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="S -> G" /CDS_Position=232 /Change="T -> C" /Codon_Change="AGT -> GGT" /Coverage=150 /locus_tag="BSU_12400" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=149 /comment="Delta6_BSU_12400_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" SCAR join(1186196,1186203) /created_by="User" /modified_by="User" /label="TF8A" N_region 1186197..1186202 /created_by="User" /note_="EcoRI site (GAATTC)" /modified_by="User" /label="TF8A" CDS <1186205..1186525 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /translation="PNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVF QVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIA AQLS*" /label="Delta6_pseudo_BSU_12810" gene <1186205..1186525 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /label="Delta6_pseudo_BSU_12810" downshifts 1186534 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" S_feature complement(1186543..1186746) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1186562..1186699) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" /label="spoIISC CDS" gene complement(1186562..1186699) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /label="spoIISC gene" downshifts complement(1186586) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1186785..1186955) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" /label="spoIISB CDS" gene complement(1186785..1186955) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /label="spoIISB gene" downshifts complement(1186791) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" /label="downshifts" CDS complement(1186955..1187701) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" /label="spoIISA CDS" gene complement(1186955..1187701) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /label="spoIISA gene" promotor_-10 complement(1187536..1187555) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1187553) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1187571..1187578) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1187727..1187745) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1187740) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1187761..1187766) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1187811..1188812) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " /label="pitB CDS" gene complement(1187811..1188812) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /label="pitB gene" downshifts complement(1187840) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1188825..1189442) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" /label="ykaA CDS" gene complement(1188825..1189442) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /label="ykaA gene" promotor_-10 complement(1189478..1189497) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1189480) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1189482..1189579) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1189513..1189517) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1189559..1189578) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1189579) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1189593..1189600) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1189624..1189643) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1189636) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1189718..1191034) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" /label="steT CDS" gene complement(1189718..1191034) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /label="steT gene" downshifts complement(1189733) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1191081..1191100) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1191097) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="upshifts" promotor_-35 complement(1191115..1191118) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1191317..1191324 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1191339..1191358 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1191351..1191422 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1191351 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="upshifts" CDS 1191423..1192373 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" /label="mhqA CDS" gene 1191423..1192373 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /label="mhqA gene" downshifts 1192361 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 1192474..1192620 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" /label="hypothetical protein CDS" gene 1192474..1192620 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /label="gene" CDS 1192628..1194778 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" /label="ykcB CDS" gene 1192628..1194778 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /label="ykcB gene" promotor_no_box 1193517..1193617 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1193577 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1193665 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1194790..1195761 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" /label="ykcC CDS" gene 1194790..1195761 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /label="ykcC gene" S_feature complement(1195118..1195759) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1195804) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" /label="downshifts" S_feature complement(1195829..1196195) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1195872) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1196175..1196190) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1196195) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1196202..1196211) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1196279..1197628) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " /label="htrA CDS" gene complement(1196279..1197628) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /label="htrA gene" downshifts complement(1196293) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1197668..1197675 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1197680..1197699) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1197688 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="upshifts" promotor_-10 1197690..1197709 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1197698) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1197700..1197782) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1197710..1197717) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1197739..1197745 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1197760..1197779 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1197763 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1197765..1197784) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1197782) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1197797..1198615 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" /label="proCC CDS" gene 1197797..1198615 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /label="proCC gene" promotor_-35 complement(1197800..1197803) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1198593 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1198672..1198679 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1198694..1198713 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1198698 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1198744..1199568 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" /label="dppA CDS" gene 1198744..1199568 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /label="dppA gene" CDS 1199585..1200511 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" /label="dppB CDS" gene 1199585..1200511 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /label="dppB gene" CDS 1200517..1201479 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" /label="dppC CDS" gene 1200517..1201479 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /label="dppC gene" promotor_-35 1201211..1201216 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1201232..1201250 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1201233 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1201484..1202491 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" /label="dppD CDS" gene 1201484..1202491 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /label="dppD gene" CDS 1202494..1204143 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" /label="dppE CDS" gene 1202494..1204143 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /label="dppE gene" downshifts 1204137 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" /label="downshifts" CDS 1204231..1205190 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" /label="ldcA CDS" gene 1204231..1205190 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /label="ldcA gene" CDS 1205187..1206287 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" /label="aeeB CDS" gene 1205187..1206287 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /label="aeeB gene" CDS 1206284..1207174 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" /label="eepC CDS" gene 1206284..1207174 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /label="eepC gene" CDS 1207187..1208176 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" /label="ykfD CDS" gene 1207187..1208176 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /label="ykfD gene" S_feature complement(1207470..1208197) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1208166 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" S_feature 1208211..1209379 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1208219..1209268) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" /label="pgl CDS" gene complement(1208219..1209268) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /label="pgl gene" downshifts complement(1208242) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1209295..1209314) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1209306) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1209329..1209336) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1209358..1210218) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" /label="ddaH CDS" gene complement(1209358..1210218) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /label="ddaH gene" promotor_-10 complement(1210243..1210261) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1210260) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1210277..1210283) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1210292..1210299 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1210313..1210332 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1210320 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="upshifts" CDS 1210378..1210896 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" /label="ykhA CDS" gene 1210378..1210896 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /label="ykhA gene" downshifts 1210887 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" /label="downshifts" promotor_-35 1210961..1210967 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1210979..1211085 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1210979 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="upshifts" promotor_-10 1210981..1210992 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1211060..1211063 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1211079..1211098 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1211087 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1211135..1212334 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" /label="hmpA CDS" gene 1211135..1212334 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /label="hmpA gene" downshifts 1212323 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1212368..1212739 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1212411..1212635) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" /label="ykzH CDS" gene complement(1212411..1212635) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /label="ykzH gene" promotor_-35 1212715..1212721 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1212735..1212746 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1212741 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1212780..1213511 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" /label="ykjA CDS" gene 1212780..1213511 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /label="ykjA gene" downshifts 1213489 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1213550..1213558 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1213569..1213587 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1213577 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1213603..1214130 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" /label="ykkA CDS" gene 1213603..1214130 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /label="ykkA gene" CDS 1214120..1214638 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" /label="ykkB CDS" gene 1214120..1214638 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /label="ykkB gene" promotor_-35 1214632..1214639 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1214653..1214672 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1214656 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="upshifts" misc_RNA 1214671..1214782 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" /label="gdwA RNA" gene 1214671..1214782 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /label="gdwA gene" downshifts 1214745 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" /label="downshifts" CDS 1214860..1215198 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" /label="gdnC CDS" gene 1214860..1215198 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /label="gdnC gene" CDS 1215198..1215515 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" /label="gdnD CDS" gene 1215198..1215515 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /label="gdnD gene" promotor_-35 1215515..1215518 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1215534..1215553 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1215546 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1215586..1216488 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" /label="purU CDS" gene 1215586..1216488 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /label="purU gene" downshifts 1216479 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" /label="downshifts" promotor_-35 1216535..1216541 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1216547 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1216555..1216574 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1216576..1216786 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" /label="pswB RNA" gene 1216576..1216786 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /label="pswB gene" downshifts 1216744 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1216839..1217936 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" /label="proB CDS" gene 1216839..1217936 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /label="proB gene" promotor_-35 1217026..1217028 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1217030..1217034 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1217030 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1217948..1219195 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" /label="proA CDS" gene 1217948..1219195 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /label="proA gene" downshifts 1219186 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1219257..1219264 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1219279..1219298 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1219288 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1219321..1219746 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" /label="ohrA CDS" gene 1219321..1219746 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /label="ohrA gene" downshifts 1219735 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1219777..1220220) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" /label="ohrR CDS" gene complement(1219777..1220220) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /label="ohrR gene" downshifts complement(1219811) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1220247..1220266) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1220253) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1220281..1220284) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1220302..1220308 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1220322..1220340 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1220328 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="upshifts" CDS 1220363..1220773 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" /label="ohrB CDS" gene 1220363..1220773 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /label="ohrB gene" downshifts 1220751 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" /label="downshifts" CDS 1220800..1220970 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" /label="ykzN CDS" gene 1220800..1220970 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /label="ykzN gene" S_feature 1220971..1221648 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1221020..1221490) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" /label="guaN CDS" gene complement(1221020..1221490) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /label="guaN gene" downshifts complement(1221044) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1221512..1221531) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1221528) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1221530..1221637) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1221547..1221550) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1221606 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1221663..1223951) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" /label="metE CDS" gene complement(1221663..1223951) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /label="metE gene" downshifts complement(1221682) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature complement(1223952..1224014) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1223974..1224074) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1224014) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1224079..1224234) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" /label="mswB RNA" gene complement(1224079..1224234) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /label="mswB gene" downshifts complement(1224080) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1224267..1224286) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1224279) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1224281..1224366) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1224302..1224309) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1224367..1225326) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" /label="ispA CDS" gene complement(1224367..1225326) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /label="ispA gene" S_feature complement(1225327..1225378) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1225371..1225390) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1225383) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1225404..1225410) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1225495..1225498 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1225511 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1225514..1225533 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1225549..1226382 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" /label="rsbRB CDS" gene 1225549..1226382 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /label="rsbRB gene" downshifts 1226358 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1226413..1227177) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" /label="thiX CDS" gene complement(1226413..1227177) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /label="thiX gene" downshifts complement(1226434) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1227152..1228795) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" /label="thiW CDS" gene complement(1227152..1228795) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /label="thiW gene" CDS complement(1228782..1229381) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" /label="thiV CDS" gene complement(1228782..1229381) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /label="thiV gene" CDS complement(1229383..1229985) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" /label="thiU CDS" gene complement(1229383..1229985) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /label="thiU gene" downshifts complement(1230063) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1230082..1230194) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswB RNA" gene complement(1230082..1230194) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /label="tswB gene" promotor_-35 1230195..1230198 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1230209..1230228) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1230214..1230233 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1230225 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1230230) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1230243..1230250) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1230296..1230982 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" /label="ykoG CDS" gene 1230296..1230982 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /label="ykoG gene" CDS 1230986..1232350 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" /label="ykoH CDS" gene 1230986..1232350 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /label="ykoH gene" CDS 1232347..1233027 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" /label="ykoI CDS" gene 1232347..1233027 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /label="ykoI gene" promotor_-35 1233056..1233061 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1233077..1233095 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1233080 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1233119..1233631 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" /label="ykoJ CDS" gene 1233119..1233631 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /label="ykoJ gene" downshifts 1233617 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 1233662..1233668 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1233682..1233693 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1233683 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1233714..1233851 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" /label="ykzD CDS" gene 1233714..1233851 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /label="ykzD gene" downshifts 1233824 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1233910..1233917 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1233931..1233950 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1233933..1234252 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1233933 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1233965..1234118 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="swmG RNA" gene 1233965..1234118 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /label="swmG gene" promotor_-35 1234230..1234239 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1234252..1234271 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1234254..1234355 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1234254 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" CDS 1234356..1235711 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" /label="mgtE CDS" gene 1234356..1235711 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /label="mgtE gene" downshifts 1235702 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1235754..1236086) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" /label="tnrA CDS" gene complement(1235754..1236086) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /label="tnrA gene" promotor_-10 complement(1236102..1236121) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1236112) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1236114..1236502) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1236137..1236142) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1236174..1236274 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1236234 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="upshifts" CDS 1236281..1236436 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" /label="ykzB CDS" gene 1236281..1236436 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /label="ykzB gene" promotor_-35 1236445..1236452 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1236459..1236476 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1236476 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1236487..1236506) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1236502) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1236520..1236526) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1236524..1236706 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" /label="ykoL CDS" gene 1236524..1236706 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /label="ykoL gene" downshifts 1236674 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1236731..1236739 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1236750..1236768 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1236756..1236838 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1236756 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" CDS 1236839..1237303 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" /label="ykoM CDS" gene 1236839..1237303 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /label="ykoM gene" downshifts 1237288 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" /label="downshifts" CDS complement(1237318..1238439) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" /label="ykoN CDS" gene complement(1237318..1238439) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /label="ykoN gene" promotor_-35 1237727..1237735 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1237749..1237768 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1237752..1238530 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1237752 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1238468..1238479) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1238488) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1238494..1238500) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1238531..1239082 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" /label="ykoP CDS" gene 1238531..1239082 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /label="ykoP gene" downshifts 1239050 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(1239110..1239922) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" /label="ykoQ CDS" gene complement(1239110..1239922) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /label="ykoQ gene" promotor_-10 complement(1239882..1239901) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1239896) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1239915..1239920) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1240023..1240029 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1240040..1240114 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1240040 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1240043..1240054 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1240115..1241809 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" /label="ykoS CDS" gene 1240115..1241809 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /label="ykoS gene" CDS 1241822..1242835 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" /label="ykoT CDS" gene 1241822..1242835 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /label="ykoT gene" downshifts 1242820 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(1242861..1244696) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" /label="ligD CDS" gene complement(1242861..1244696) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /label="ligD gene" downshifts complement(1242910) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1244700..1245635) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" /label="ligV CDS" gene complement(1244700..1245635) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /label="ligV gene" promotor_-10 complement(1245606..1245617) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1245616) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1245632..1245638) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1245672..1248074) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" /label="dgcW CDS" gene complement(1245672..1248074) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /label="dgcW gene" downshifts complement(1245704) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1247922..1248124) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1248113..1248131) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1248124) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1248145..1248152) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1248191..1248198 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1248212..1248231 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1248224 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="upshifts" CDS 1248255..1248920 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" /label="ykoX CDS" gene 1248255..1248920 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /label="ykoX gene" promotor_-10 complement(1248789..1248808) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1248806) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1248822..1248831) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1248915..1248922 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1248937..1248956 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1248950 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1248976..1249109 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="mnrW RNA" gene 1248976..1249109 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /label="mnrW gene" CDS 1248997..1249971 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" /label="ykoY CDS" gene 1248997..1249971 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /label="ykoY gene" downshifts 1249060 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" /label="downshifts" downshifts 1249959 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1250081..1250089 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1250103..1250111 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1250113 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="upshifts" S_feature 1250116..1250202 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1250175..1250182 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1250196..1250215 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1250204 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="upshifts" CDS 1250235..1250990 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" /label="sigI CDS" gene 1250235..1250990 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /label="sigI gene" CDS 1250987..1252132 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" /label="rsgI CDS" gene 1250987..1252132 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /label="rsgI gene" S_feature 1252133..1253292 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1252143..1252337) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" /label="sspD CDS" gene complement(1252143..1252337) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /label="sspD gene" downshifts complement(1252150) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1252380..1252391) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1252390) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1252406..1252412) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1252468..1253169) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" /label="htpK CDS" gene complement(1252468..1253169) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /label="htpK gene" downshifts complement(1252502) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1253170..1253250) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1253242..1253261) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1253250) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1253266..1253273 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1253275..1253282) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1253287..1253306 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1253294 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="upshifts" CDS 1253340..1254236 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" /label="htpX CDS" gene 1253340..1254236 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /label="htpX gene" downshifts 1254230 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1254341..1254345 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1254361..1254380 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1254365 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="upshifts" CDS 1254410..1255759 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " /label="ktrD CDS" gene 1254410..1255759 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /label="ktrD gene" downshifts 1255747 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1255808..1255814 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1255828..1255839 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1255836..1255903 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1255836 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1255904..1256059 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" /label="ykzP CDS" gene 1255904..1256059 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /label="ykzP gene" CDS 1256062..1256238 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" /label="ykzE CDS" gene 1256062..1256238 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /label="ykzE gene" promotor_no_box 1256128..1256228 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1256188 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1256234 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1256281..1257303) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" /label="ykrP CDS" gene complement(1256281..1257303) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /label="ykrP gene" downshifts complement(1256304) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1257348..1257367) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1257364) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1257379..1257385) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1257492..1257500 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1257508 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1257511..1257529 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1257556..1259772 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" /label="kinE CDS" gene 1257556..1259772 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /label="kinE gene" S_feature complement(1259547..1260487) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1259625..1259632 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1259647..1259666 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1259649 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="upshifts" CDS 1259769..1260266 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" /label="ogt CDS" gene 1259769..1260266 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /label="ogt gene" S_feature 1260267..1260506 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1260356..1260481 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" /label="hypothetical protein CDS" gene 1260356..1260481 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /label="gene" downshifts 1260474 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1260515..1261576) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" /label="mtnA CDS" gene complement(1260515..1261576) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /label="mtnA gene" downshifts complement(1260532) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(1261584..1262777) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" /label="mtnK CDS" gene complement(1261584..1262777) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /label="mtnK gene" downshifts 1261644 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts complement(1262864) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1262870..1263026) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" /label="mswC RNA" gene complement(1262870..1263026) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /label="mswC gene" promotor_-10 complement(1263061..1263080) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1263062) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1263096..1263103) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1263106..1263109 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1263110..1263889) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" /label="mtnU CDS" gene complement(1263110..1263889) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /label="mtnU gene" promotor_-10 1263125..1263144 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1263134 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1263582..1263589 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1263602..1263621 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1263617 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="upshifts" S_feature 1263624..1263941 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1263911..1263918 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1263919..1263938) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1263933..1263952 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1263933) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" upshifts 1263943 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1263954..1263961) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1263984..1265180 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" /label="mtnE CDS" gene 1263984..1265180 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /label="mtnE gene" promotor_-35 1265162..1265169 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1265184..1265203 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1265203 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1265219..1265319 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" /label="mswD RNA" gene 1265219..1265319 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /label="mswD gene" downshifts 1265318 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS 1265404..1266621 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" /label="mtnW CDS" gene 1265404..1266621 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /label="mtnW gene" CDS 1266618..1267325 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" /label="mtnX CDS" gene 1266618..1267325 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /label="mtnX gene" CDS 1267283..1267912 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" /label="mtnB CDS" gene 1267283..1267912 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /label="mtnB gene" CDS 1267927..1268463 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" /label="mtnD CDS" gene 1267927..1268463 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /label="mtnD gene" S_feature complement(1268310..1268503) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1268463 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1268504..1268824) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" /label="ykvA CDS" gene complement(1268504..1268824) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /label="ykvA gene" downshifts complement(1268562) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(1268825..1268914) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1268850..1268856 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1268871..1268889 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1268881 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" S_feature 1268882..1268966 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1268896..1268915) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1268913) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1268930..1268933) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1268940..1268947 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1268962..1268981 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1268968..1269026 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1268968 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1269024) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1269027..1269284 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" /label="spo0E CDS" gene 1269027..1269284 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /label="spo0E gene" downshifts 1269278 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS 1269370..1269801 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" /label="eag CDS" gene 1269370..1269801 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /label="eag gene" downshifts complement(1269841) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" SCAR join(1269876,1269986) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27_027" N_region 1269877..1269985 /modified_by="User" /label="IIG_Bs27_027" CDS complement(1269996..1272095) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" /label="clpE CDS" gene complement(1269996..1272095) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /label="clpE gene" downshifts complement(1270018) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" /label="downshifts" S_feature complement(1272096..1272346) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1272306..1272406) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1272346) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1272382..1272387 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1272397 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1272403..1272421 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1272460..1273503 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" /label="ykvI CDS" gene 1272460..1273503 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /label="ykvI gene" S_feature 1273504..1273595 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1273572..1273576 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1273593..1273612 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1273597 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1273642..1273686 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" /label="qswA RNA" gene 1273642..1273686 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /label="qswA gene" downshifts 1273663 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1273708..1273815 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1273816..1274475 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" /label="queC CDS" gene 1273816..1274475 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /label="queC gene" CDS 1274468..1274917 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" /label="queD CDS" gene 1274468..1274917 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /label="queD gene" CDS 1274910..1275641 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" /label="queE CDS" gene 1274910..1275641 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /label="queE gene" CDS 1275659..1276156 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" /label="queF CDS" gene 1275659..1276156 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /label="queF gene" S_feature 1276157..1276433 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1276391 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1276401) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature complement(1276470..1276714) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1276511) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1276715..1277071) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" /label="ykvN CDS" gene complement(1276715..1277071) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /label="ykvN gene" misc_feature complement(1277102..1277121) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1277119) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1277156..1277174 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1277161 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="upshifts" CDS 1277240..1277986 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" /label="ykvO CDS" gene 1277240..1277986 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /label="ykvO gene" downshifts 1278041 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1278389..1278397 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1278411..1278430 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1278415 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="upshifts" CDS 1278467..1279666 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" /label="ykvP CDS" gene 1278467..1279666 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /label="ykvP gene" promotor_-35 1278549..1278555 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1278570..1278588 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1278576 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1279635..1279637 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1279657..1279675 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1279669 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1279682..1279909 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" /label="ykzQ CDS" gene 1279682..1279909 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /label="ykzQ gene" misc_feature complement(1279759..1279778) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1279767) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1279910..1280005 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1280006..1280704 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" /label="ykvQ CDS" gene 1280006..1280704 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo /label="ykvQ gene" S_feature complement(1280657..1281483) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1280685..1280936 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" /label="ykzR CDS" gene 1280685..1280936 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo /label="ykzR gene" misc_feature 1281186..1281201 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1281209..1281420 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1281209 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="upshifts" downshifts 1281385 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1281472..1281491) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1281494) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1281507..1281514) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1281559..1281566 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1281581..1281600 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1281583 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="upshifts" CDS 1281619..1281909 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" /label="ykvR CDS" gene 1281619..1281909 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /label="ykvR gene" S_feature complement(1281946..1282029) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1281989) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1282030..1282215) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" /label="ykvS CDS" gene complement(1282030..1282215) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /label="ykvS gene" promotor_-10 complement(1282248..1282267) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1282259) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1282261..1282605) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1282281..1282288) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1282314..1282319 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1282335..1282354 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1282342 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="upshifts" CDS 1282381..1282575 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" /label="ykzS CDS" gene 1282381..1282575 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /label="ykzS gene" downshifts 1282551 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1282596..1282614) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1282612) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1282631..1282636) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1282874..1283500 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" /label="ykvT CDS" gene 1282874..1283500 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /label="ykvT gene" downshifts 1283431 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1283557..1283562 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1283569 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1283578..1283596 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1283618..1284955 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" /label="ykvU CDS" gene 1283618..1284955 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /label="ykvU gene" CDS 1285006..1285503 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" /label="stoA CDS" gene 1285006..1285503 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /label="stoA gene" promotor_-35 1285352..1285358 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1285367 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1285373..1285391 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1285477 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1285598..1285604 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1285615..1285634 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1285627 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1285631..1285738 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1285739..1287652 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" /label="pfeT CDS" gene 1285739..1287652 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /label="pfeT gene" promotor_-10 complement(1285888..1285907) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1285905) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1285920..1285929) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1286056..1286075) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1286081) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1286089..1286095) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1287633 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1287709) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1287920..1287939) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1287929) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1287953..1287960) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1288004..1288023 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1288014 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="upshifts" CDS 1288059..1289150 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" /label="papB CDS" gene 1288059..1289150 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /label="papB gene" downshifts 1288799 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts 1289129 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" S_feature complement(1289163..1289381) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1289174..1289431 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1289368..1289387) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1289381) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1289403..1289410) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1289432..1290397 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" /label="ykvZ CDS" gene 1289432..1290397 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /label="ykvZ gene" promotor_-35 1290415..1290422 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1290437..1290456 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1290449 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="upshifts" CDS 1290460..1291326 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" /label="glcT CDS" gene 1290460..1291326 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /label="glcT gene" promotor_-35 1291181..1291185 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1291202..1291221 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1291210 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" downshifts 1291328 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_RNA 1291373..1291524 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" /label="gswA RNA" S_feature 1291373..1291524 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1291373..1291524 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /label="gswA gene" promotor_-35 1291502..1291508 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1291522..1291533 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1291526 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="upshifts" CDS 1291555..1293654 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" /label="ptsG CDS" gene 1291555..1293654 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /label="ptsG gene" promotor_-35 1293672..1293676 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1293692..1293711 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1293703 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1293752..1294018 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" /label="ptsH CDS" gene 1293752..1294018 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /label="ptsH gene" CDS 1294018..1295730 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" /label="ptsI CDS" gene 1294018..1295730 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /label="ptsI gene" downshifts 1295717 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-35 1295770..1295776 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1295791..1295802 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1295794 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1295821..1296060 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" /label="splA CDS" gene 1295821..1296060 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /label="splA gene" S_feature complement(1295841..1297180) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1296138..1297166 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" /label="splB CDS" gene 1296138..1297166 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /label="splB gene" downshifts 1297136 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1297181..1297861) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" /label="ykwB CDS" gene complement(1297181..1297861) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /label="ykwB gene" promotor_-10 complement(1297871..1297890) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1297894) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1297905..1297912) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1297946..1297953 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1297967..1297985 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1297973 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="upshifts" CDS 1297996..1299963 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" /label="mcpC CDS" gene 1297996..1299963 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /label="mcpC gene" misc_feature complement(1298436..1298451) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1298448) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1299934 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1300007..1300009 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1300025..1300044 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1300035 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1300077) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" /label="downshifts" CDS 1300101..1300967 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" /label="ohaC CDS" gene 1300101..1300967 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /label="ohaC gene" downshifts 1300947 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1301006..1301779) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" /label="ykwD CDS" gene complement(1301006..1301779) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /label="ykwD gene" downshifts complement(1301023) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1301811..1301830) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1301821) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1302054..1302073 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1302067 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1302069..1302172 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1302116..1304230 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" /label="pbpH CDS" gene 1302116..1304230 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /label="pbpH gene" promotor_-10 complement(1303409..1303427) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1303421) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1303443..1303448) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1304211 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" /label="downshifts" promotor_-35 1304303..1304311 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1304323..1304341 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1304335 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="upshifts" CDS 1304394..1306214 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" /label="kinA CDS" gene 1304394..1306214 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /label="kinA gene" CDS complement(1306225..1307406) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" /label="dapX CDS" gene complement(1306225..1307406) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /label="dapX gene" downshifts complement(1306259) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1307434..1307453) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1307450) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1307482..1307500) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1307494) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1307496..1307564) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1307515..1307520) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1307558..1307577) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1307564) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1307608..1307769) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" /label="ykzT CDS" gene complement(1307608..1307769) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /label="ykzT gene" promotor_-10 complement(1307792..1307811) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1307805) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1307825..1307832) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1307906..1307913 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1307925 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1307926..1307944 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1307973..1308884 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" /label="cheV CDS" gene 1307973..1308884 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /label="cheV gene" downshifts complement(1307978) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" /label="downshifts" promotor_-35 1308427..1308435 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1308449..1308466 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1308452 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1308869 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1308928..1309392) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" /label="kre CDS" gene complement(1308928..1309392) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /label="kre gene" downshifts complement(1308946) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1309422..1309441) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1309432) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1309456..1309463) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1309518..1310810) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" /label="ykuC CDS" gene complement(1309518..1310810) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /label="ykuC gene" downshifts complement(1309540) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1310834..1310853) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1310838) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="upshifts" promotor_-35 complement(1310869..1310873) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1310886..1311380) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" /label="ltdD CDS" gene complement(1310886..1311380) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /label="ltdD gene" promotor_-10 complement(1311396..1311415) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1311412) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1311429..1311438) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1311437..1312297) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" /label="ppeE CDS" gene complement(1311437..1312297) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /label="ppeE gene" misc_feature complement(1312318..1312337) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1312331) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="upshifts" promotor_-35 1312368..1312375 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1312391..1312410 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1312404 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="upshifts" CDS 1312440..1313204 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" /label="fadH CDS" gene 1312440..1313204 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /label="fadH gene" S_feature 1313205..1313353 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1313334..1313352 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1313355..1313504 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1313355 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1313402) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" /label="downshifts" CDS 1313505..1315235 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" /label="ykuG CDS" gene 1313505..1315235 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /label="ykuG gene" CDS 1315301..1315819 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" /label="ykzU CDS" gene 1315301..1315819 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /label="ykzU gene" downshifts 1315817 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 1315862..1315867 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1315880..1315899 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1315883 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="upshifts" CDS 1315915..1316463 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" /label="ykuH CDS" gene 1315915..1316463 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /label="ykuH gene" S_feature 1316464..1316615 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1316616..1317839 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" /label="ykuI CDS" gene 1316616..1317839 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /label="ykuI gene" promotor_-10 complement(1317802..1317820) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1317812) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1317818 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(1317835..1317840) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1317888..1317895 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1317907..1318008 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1317907 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1317910..1317929 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1317925..1318008 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" /label="fsrA RNA" gene 1317925..1318008 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /label="fsrA gene" downshifts 1317965 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 1318019..1318024 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1318039..1318323 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1318039 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1318041..1318059 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1318300..1318306 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1318320..1318331 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1318325..1318412 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1318325 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" misc_feature 1318401..1318420 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1318414 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1318485..1318724 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" /label="ykuJ CDS" gene 1318485..1318724 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /label="ykuJ gene" S_feature 1318725..1318833 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1318834..1319352 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" /label="ykuK CDS" gene 1318834..1319352 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /label="ykuK gene" promotor_-35 1319389..1319396 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1319410..1319429 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1319424 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1319486..1319683 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" /label="abbA CDS" gene 1319486..1319683 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /label="abbA gene" downshifts 1319679 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" /label="downshifts" S_feature 1319724..1319820 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1319821..1320264 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" /label="ykuL CDS" gene 1319821..1320264 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /label="ykuL gene" S_feature 1320265..1320372 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1320340..1320345 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1320360..1320379 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1320374 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1320413..1321294 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" /label="ccpC CDS" gene 1320413..1321294 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /label="ccpC gene" downshifts 1321273 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1321329..1321336 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1321351..1321370 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1321356 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1321406..1321882 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" /label="fldN CDS" gene 1321406..1321882 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /label="fldN gene" CDS 1321872..1322765 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" /label="ykuO CDS" gene 1321872..1322765 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /label="ykuO gene" CDS 1322781..1323236 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" /label="fldP CDS" gene 1322781..1323236 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /label="fldP gene" promotor_-10 complement(1323052..1323071) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1323065) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1323085..1323093) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1323230 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" /label="downshifts" promotor_-35 1323275..1323282 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1323296..1323315 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1323297 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1323341..1324051 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" /label="dapH CDS" gene 1323341..1324051 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /label="dapH gene" downshifts complement(1323350) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1323460..1323464) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1323460) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1324121..1325245 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" /label="dapI CDS" gene 1324121..1325245 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /label="dapI gene" promotor_-35 1325257..1325263 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1325277..1325288 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1325279 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1325283..1325297) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1325307..1325311) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1325307..1325552 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" /label="ykuS CDS" gene 1325307..1325552 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /label="ykuS gene" upshifts complement(1325308) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1325540 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1325585..1326535 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1325589..1326392) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" /label="mscT CDS" gene complement(1325589..1326392) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /label="mscT gene" downshifts complement(1325601) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1326443..1326462) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1326452) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1326476..1326483) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1326508..1326515 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1326530..1326549 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1326537..1326628 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1326537 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="upshifts" CDS 1326629..1327171 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" /label="ahpA CDS" gene 1326629..1327171 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /label="ahpA gene" CDS 1327243..1327689 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" /label="ykuV CDS" gene 1327243..1327689 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /label="ykuV gene" downshifts 1327697 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1328082..1328089 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1328102 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1328104..1328123 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1328155..1328730 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" /label="rok CDS" gene 1328155..1328730 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /label="rok gene" downshifts 1328708 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1328771..1329736) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" /label="sppO CDS" gene complement(1328771..1329736) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /label="sppO gene" downshifts complement(1328784) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1329080..1329081 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1329099..1329118 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1329105..1329829 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1329105 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1329757..1329775) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1329778) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1329790..1329795) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1329816..1329822 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1329832 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1329836..1329855 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1329873..1330472 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" /label="mobA CDS" gene 1329873..1330472 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /label="mobA gene" CDS 1330523..1331542 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" /label="moeB CDS" gene 1330523..1331542 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /label="moeB gene" CDS 1331560..1332852 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" /label="moeA CDS" gene 1331560..1332852 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /label="moeA gene" CDS 1332813..1333334 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" /label="mobB CDS" gene 1332813..1333334 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /label="mobB gene" CDS 1333334..1333807 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" /label="moaE CDS" gene 1333334..1333807 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /label="moaE gene" CDS 1333800..1334033 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" /label="moaD CDS" gene 1333800..1334033 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /label="moaD gene" downshifts 1334012 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1334078..1334083 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1334100..1334118 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1334108 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="upshifts" S_feature 1334120..1334206 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1334196..1334199 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1334208 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1334214..1334233 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1334257..1336014 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" /label="yknU CDS" gene 1334257..1336014 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /label="yknU gene" CDS 1336026..1337840 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" /label="yknV CDS" gene 1336026..1337840 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /label="yknV gene" promotor_-10 complement(1336463..1336482) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1336473) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1336497..1336504) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1337891..1337900 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1337912..1337927 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1337916 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="upshifts" CDS 1337950..1338645 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" /label="skiW CDS" gene 1337950..1338645 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /label="skiW gene" CDS 1338650..1339783 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" /label="skiX CDS" gene 1338650..1339783 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /label="skiX gene" CDS 1339784..1340476 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" /label="skiY CDS" gene 1339784..1340476 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /label="skiY gene" CDS 1340473..1341666 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" /label="skiZ CDS" gene 1340473..1341666 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /label="skiZ gene" downshifts 1341644 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" /label="downshifts" promotor_-35 1341715..1341721 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1341735..1341746 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1341743 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1341788..1341795 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1341810..1341829 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1341815..1341906 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1341815 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="upshifts" promotor_-35 1341870..1341877 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1341891..1341910 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1341908 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="upshifts" CDS 1341946..1342701 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" /label="fruR CDS" gene 1341946..1342701 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /label="fruR gene" upshifts complement(1342094) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1342096..1342098) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1342698..1343609 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" /label="fruK CDS" gene 1342698..1343609 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /label="fruK gene" CDS 1343624..1345531 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" /label="fruA CDS" gene 1343624..1345531 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /label="fruA gene" downshifts 1345516 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1345600..1345607 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1345618..1345637 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1345621 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="upshifts" CDS 1345676..1346257 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" /label="sipT CDS" gene 1345676..1346257 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /label="sipT gene" downshifts 1346242 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1346286 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1346291..1346560) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" /label="ykoA CDS" gene complement(1346291..1346560) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /label="ykoA gene" downshifts complement(1346296) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(1346561..1346626) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1346607..1346626) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1346626) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1346679..1346686 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1346697..1346716 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1346701 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="upshifts" CDS 1346741..1348363 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" /label="ykpA CDS" gene 1346741..1348363 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /label="ykpA gene" downshifts 1348351 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" /label="downshifts" CDS 1348420..1349331 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" /label="panE CDS" gene 1348420..1349331 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /label="panE gene" downshifts 1349336 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1349365..1350597) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" /label="ampS CDS" gene complement(1349365..1350597) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /label="ampS gene" downshifts complement(1349376) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1350615..1350634) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1350639) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1350649..1350654) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1350707..1350841) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" /label="ykpC CDS" gene complement(1350707..1350841) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /label="ykpC gene" downshifts complement(1350718) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1350863..1350881) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1350874) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1350876..1350941) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1350897..1350902) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1350942..1351949) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" /label="mreBH CDS" gene complement(1350942..1351949) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /label="mreBH gene" upshifts complement(1351995) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1351996..1352004) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1352018..1352026) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1352136..1352145 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1352157 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="upshifts" promotor_-10 1352158..1352173 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1352160..1352232 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1352233..1352511 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" /label="abhA CDS" gene 1352233..1352511 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /label="abhA gene" downshifts 1352509 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" /label="downshifts" S_feature complement(1352543..1354172) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1352554..1352658 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1352566) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1352640..1352647 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1352659..1352678 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1352660 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="upshifts" CDS 1352701..1353987 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" /label="kinC CDS" gene 1352701..1353987 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /label="kinC gene" CDS 1354003..1354836 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" /label="ykqA CDS" gene 1354003..1354836 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /label="ykqA gene" promotor_-10 complement(1354169..1354187) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1354184) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1354203..1354208) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1354899..1355564 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" /label="ktrC CDS" gene 1354899..1355564 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /label="ktrC gene" downshifts 1355548 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1355655..1355661 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1355676..1355695) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1355676..1355695 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1355688 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1355690) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1355719..1357452 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" /label="adeC CDS" gene 1355719..1357452 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /label="adeC gene" S_feature complement(1356847..1357451) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1357441 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1357486..1359153) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" /label="rnjA CDS" gene complement(1357486..1359153) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /label="rnjA gene" downshifts complement(1357496) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1359159..1359368) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" /label="rnpZA CDS" gene complement(1359159..1359368) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /label="rnpZA gene" promotor_-10 complement(1359405..1359424) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1359427) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1359429..1359606) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1359439..1359442) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1359607) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1359609..1359620) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1359634..1359640) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1359679..1359686 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1359700..1359719 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1359716 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1359754..1360527 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" /label="ykrA CDS" gene 1359754..1360527 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /label="ykrA gene" downshifts 1360498 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1360563..1361117) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" /label="defB CDS" gene complement(1360563..1361117) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /label="defB gene" downshifts complement(1360574) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1361139..1361158) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1361149) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1361173..1361180) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1361202 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1361226) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(1361227..1361385) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" /label="ykzV CDS" gene complement(1361227..1361385) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /label="ykzV gene" CDS complement(1361292..1361435) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" /label="putative antitoxin CDS" gene complement(1361292..1361435) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /label="gene" promotor_-35 1361381..1361385 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1361386..1361454) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1361395..1361409 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1361422 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1361438..1361457) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1361467) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1361470..1361479) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1361541..1361548 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1361562..1361581 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1361566 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1361599..1362270 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" /label="ykyA CDS" gene 1361599..1362270 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /label="ykyA gene" promotor_-35 1361938..1361947 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1361960..1361978 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1361972 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1362217 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 1362445..1362450 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1362467..1362486 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1362468..1362693 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1362468 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1362472..1362491) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1362488) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1362592..1362600) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1362598) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1362614..1362622) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1362694..1363809 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" /label="pdhA CDS" gene 1362694..1363809 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /label="pdhA gene" CDS 1363813..1364790 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" /label="pdhB CDS" gene 1363813..1364790 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /label="pdhB gene" S_feature 1364791..1364904 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1364825..1364844) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1364842) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1364859..1364862) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1364905..1366233 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" /label="pdhC CDS" gene 1364905..1366233 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /label="pdhC gene" promotor_-35 1365049..1365056 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1365071..1365090 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1365074 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="upshifts" CDS 1366238..1367650 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" /label="pdhD CDS" gene 1366238..1367650 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /label="pdhD gene" downshifts 1367647 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1367695..1368069) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" /label="slp CDS" gene complement(1367695..1368069) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /label="slp gene" downshifts complement(1367743) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(1368100..1368119) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1368110) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1368273..1368278 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1368294..1368312 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1368304 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="upshifts" S_feature 1368308..1368417 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1368340) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1368401..1368408 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1368419 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1368423..1368442 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1368438..1368648 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" /label="srrA RNA" gene 1368438..1368648 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /label="srrA gene" CDS 1368488..1368607 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" /label="rgpA CDS" gene 1368488..1368607 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /label="rgpA gene" downshifts complement(1368494) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts 1368594 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1368639..>1370238 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1368647..1370119) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" /label="speA CDS" gene complement(1368647..1370119) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /label="speA gene" downshifts complement(1368665) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(1370120..1370215) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1370198..1370217) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1370215) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1370222..1370225 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1370232..>1370238) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 1370238..1370239 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs27_019" CDS 1370436..1372376 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" /label="ylaA CDS" gene 1370436..1372376 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /label="ylaA gene" CDS 1372366..1372635 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" /label="ylaB CDS" gene 1372366..1372635 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /label="ylaB gene" promotor_-35 1372601..1372605 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1372619..1372638 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1372632 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1372635..1373156 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" /label="sigP CDS" gene 1372635..1373156 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /label="sigP gene" CDS 1373153..1373446 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" /label="sigQ CDS" gene 1373153..1373446 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /label="sigQ gene" CDS complement(1373486..1374097) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" /label="ylaE CDS" gene complement(1373486..1374097) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /label="ylaE gene" downshifts complement(1373500) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1374129..1374148) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1374138) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1374163..1374166) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1374353) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1374370..1374558) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" /label="ylaF CDS" gene complement(1374370..1374558) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /label="ylaF gene" downshifts complement(1374424) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1374580..1374599) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1374597) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1374612..1374619) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1374625..1374644 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1374632 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="upshifts" CDS 1374671..1376509 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" /label="bipA CDS" gene 1374671..1376509 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /label="bipA gene" CDS 1376566..1376883 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" /label="ylaH CDS" gene 1376566..1376883 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /label="ylaH gene" downshifts 1376857 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(1376932) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1376939..1377148) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" /label="ylaI CDS" gene complement(1376939..1377148) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /label="ylaI gene" misc_feature complement(1377162..1377181) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1377177) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1377231..1377860) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" /label="ylaJ CDS" gene complement(1377231..1377860) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /label="ylaJ gene" downshifts complement(1377262) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1377762..1377780) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1377768) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1377792..1377800) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1377895..1377906) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1377900) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1377912..1377917 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1377921..1377927) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1377933..1377951 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1377933 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="upshifts" S_feature 1377934..1378014 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1378015..1379343 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" /label="ylaK CDS" gene 1378015..1379343 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /label="ylaK gene" S_feature complement(1379199..1379346) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1379242) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 1379344..1379934 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1379347..1379832) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" /label="ylaL CDS" gene complement(1379347..1379832) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /label="ylaL gene" promotor_-10 complement(1379844..1379863) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1379872) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1379878..1379885) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1379935..1380864 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" /label="glsB CDS" gene 1379935..1380864 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /label="glsB gene" misc_feature 1380449..1380468 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1380458 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="upshifts" promotor_-35 1380888..1380891 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1380906..1380925 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1380914 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1380962..1381243 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" /label="ylaN CDS" gene 1380962..1381243 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /label="ylaN gene" downshifts 1381232 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" /label="downshifts" promotor_-35 1381306..1381309 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1381322..1381448 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1381322 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1381327..1381333 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1381449..1382660 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" /label="ftsW CDS" gene 1381449..1382660 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /label="ftsW gene" promotor_-35 1382670..1382674 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1382689..1382708 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1382708 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1382735..1386181 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" /label="pycA CDS" gene 1382735..1386181 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /label="pycA gene" promotor_-10 complement(1385747..1385765) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1385767) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1385781..1385786) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1386161 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts 1386206 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" /label="downshifts" downshifts complement(1386238) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 1386250 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(1386584..1387504) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" /label="ctaA CDS" gene complement(1386584..1387504) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /label="ctaA gene" downshifts complement(1386590) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1387544..1387563) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1387559) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1387577..1387584) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1387639..1387646 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1387660..1387679 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1387661..1387766 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1387661 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" S_feature 1387768..1387858 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1387768 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1387774..1387777 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1387792..1387808 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1387859..1388776 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" /label="ctaB CDS" gene 1387859..1388776 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /label="ctaB gene" downshifts 1388805 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" /label="downshifts" upshifts 1388824 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1388825..1388830 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1388884..1388889 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1388904..1388922 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1388912..1389015 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1388912 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" CDS 1389016..1390086 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" /label="ctaC CDS" gene 1389016..1390086 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /label="ctaC gene" CDS 1390119..1391987 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" /label="ctaD CDS" gene 1390119..1391987 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /label="ctaD gene" CDS 1391987..1392610 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" /label="ctaE CDS" gene 1391987..1392610 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /label="ctaE gene" CDS 1392613..1392945 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" /label="ctaF CDS" gene 1392613..1392945 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /label="ctaF gene" CDS 1392972..1393865 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" /label="ctaG CDS" gene 1392972..1393865 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /label="ctaG gene" downshifts 1393840 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1393897..1394259) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" /label="ylbA CDS" gene complement(1393897..1394259) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /label="ylbA gene" downshifts complement(1393916) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1394252..1394256 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1394265..1394278 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1394283..1394302) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1394287..1394398 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1394287 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1394295) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1394317..1394324) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1394399..1394845 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" /label="ylbB CDS" gene 1394399..1394845 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /label="ylbB gene" promotor_-35 1394431..1394438 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1394450..1394469 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1394455 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1394854..1394861 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1394875..1394894 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1394886 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" CDS 1394929..1395969 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" /label="ylbC CDS" gene 1394929..1395969 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /label="ylbC gene" promotor_-10 complement(1395892..1395910) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1395897) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1395926..1395931) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1395949 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 1396133..1396142 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1396156..1396175 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1396170 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="upshifts" CDS 1396201..1396599 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" /label="ylbD CDS" gene 1396201..1396599 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /label="ylbD gene" downshifts complement(1396205) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS 1396615..1396854 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" /label="ylbE CDS" gene 1396615..1396854 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /label="ylbE gene" downshifts 1396833 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1396921..1396928 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1396939..1396958 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1396944 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1396970..1397419 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" /label="ricF CDS" gene 1396970..1397419 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /label="ricF gene" downshifts 1397405 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" /label="downshifts" CDS 1397474..1397746 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" /label="ylbG CDS" gene 1397474..1397746 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /label="ylbG gene" S_feature complement(1397551..1397774) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1397749..1397869 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" /label="csfG RNA" gene 1397749..1397869 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /label="csfG gene" S_feature complement(1397776..1397899) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1397819) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" /label="downshifts" S_feature 1397870..1397975 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1397900..1397912) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1397907) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1397927..1397933) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1397956..1397960 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1397976..1397995 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1397977..1398068 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1397977 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="upshifts" CDS 1398069..1398623 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" /label="rsmD CDS" gene 1398069..1398623 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /label="rsmD gene" CDS 1398628..1399113 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" /label="coaD CDS" gene 1398628..1399113 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /label="coaD gene" downshifts 1399080 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" /label="downshifts" CDS complement(1399124..1400350) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" /label="spoVV CDS" gene complement(1399124..1400350) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /label="spoVV gene" S_feature 1399125..1400399 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1400351..1400452) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1400374..1400381 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1400393..1400412 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1400401..1400530 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1400401 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1400447..1400465) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1400462) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1400482..1400487) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1400531..1401313 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" /label="ylbK CDS" gene 1400531..1401313 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /label="ylbK gene" promotor_-35 1401093..1401099 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1401113..1401124 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1401124 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1401315..1402340 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" /label="ylbL CDS" gene 1401315..1402340 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /label="ylbL gene" downshifts 1402224 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1402357..1403604) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" /label="ylbM CDS" gene complement(1402357..1403604) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /label="ylbM gene" downshifts complement(1402384) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" /label="downshifts" promotor_-35 1403521..1403527 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1403541..1403552 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1403545 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="upshifts" CDS complement(1403601..1403786) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" /label="ylzH CDS" gene complement(1403601..1403786) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /label="ylzH gene" promotor_-35 1403619..1403623 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1403639..1403658 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1403648..1403783 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1403648 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="upshifts" promotor_-10 complement(1403677..1403696) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1403687) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1403710..1403717) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1403754..1403761 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1403775..1403794 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1403785 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1403814..1404332 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" /label="ylbN CDS" gene 1403814..1404332 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /label="ylbN gene" CDS 1404354..1404533 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" /label="rpmF CDS" gene 1404354..1404533 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /label="rpmF gene" downshifts 1404513 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1404556) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1404560..1404563) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1404614..1404619 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1404635..1404653 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1404636 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1404679..1405260 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" /label="gerR CDS" gene 1404679..1405260 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /label="gerR gene" downshifts 1405261 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1405317..1405799) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" /label="ylbP CDS" gene complement(1405317..1405799) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /label="ylbP gene" downshifts complement(1405336) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" /label="downshifts" downshifts 1405789 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1405822..1405841) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1405841) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1405855..1405862) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1405899..1405905 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1405917..1405936 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1405919 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="upshifts" CDS 1405959..1406855 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" /label="panE CDS" gene 1405959..1406855 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /label="panE gene" CDS 1406926..1408545 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" /label="bshC CDS" gene 1406926..1408545 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /label="bshC gene" downshifts 1408517 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 1408579..1408582 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1408597..1408670 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1408597..1408616 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1408597 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1408654) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" /label="downshifts" CDS 1408671..1409102 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" /label="mraZ CDS" gene 1408671..1409102 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /label="mraZ gene" CDS 1409172..1410107 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" /label="rsmH CDS" gene 1409172..1410107 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /label="rsmH gene" S_feature complement(1409774..1411226) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1410147..1410500 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" /label="ftsL CDS" gene 1410147..1410500 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /label="ftsL gene" CDS 1410497..1412647 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" /label="pbpB CDS" gene 1410497..1412647 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /label="pbpB gene" promotor_-10 complement(1411207..1411225) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1411226) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1411240..1411246) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1412630 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1412702..1412707 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1412723..1412741 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1412723 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="upshifts" CDS 1412764..1414704 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" /label="spoVD CDS" gene 1412764..1414704 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /label="spoVD gene" promotor_-35 1414500..1414506 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1414521..1414529 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1414527 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="upshifts" downshifts 1414677 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" /label="downshifts" S_feature 1414722..1414789 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1414759..1414763 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1414779..1414798 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1414791..1414879 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1414791 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" CDS 1414880..1416364 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" /label="murE CDS" gene 1414880..1416364 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /label="murE gene" S_feature 1416365..1416475 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1416476..1417450 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" /label="mraY CDS" gene 1416476..1417450 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /label="mraY gene" CDS 1417451..1418806 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" /label="murD CDS" gene 1417451..1418806 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /label="murD gene" promotor_-35 1418630..1418635 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1418651..1418669 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1418661 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="upshifts" CDS 1418867..1419967 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" /label="spoVE CDS" gene 1418867..1419967 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /label="spoVE gene" S_feature 1419968..1420089 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1420090..1421181 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" /label="murG CDS" gene 1420090..1421181 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /label="murG gene" promotor_-35 1420570..1420579 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1420592..1420607 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1420597 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" promotor_no_box 1420603..1420703 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1420663 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1421213..1422124 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" /label="murB CDS" gene 1421213..1422124 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /label="murB gene" downshifts 1422142 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" /label="downshifts" CDS 1422254..1423045 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" /label="divIB CDS" gene 1422254..1423045 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /label="divIB gene" CDS 1423042..1423737 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" /label="ylxW CDS" gene 1423042..1423737 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /label="ylxW gene" CDS 1423760..1424467 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" /label="ylxX CDS" gene 1423760..1424467 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /label="ylxX gene" CDS 1424485..1424850 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" /label="sbp CDS" gene 1424485..1424850 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /label="sbp gene" promotor_-35 1424702..1424705 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1424721..1424740 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1424737 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" S_feature 1424851..1425023 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1425024..1426346 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" /label="ftsA CDS" gene 1425024..1426346 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /label="ftsA gene" upshifts complement(1425231) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1425235..1425239) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1425254..1425258) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1426382..1427530 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" /label="ftsZ CDS" gene 1426382..1427530 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /label="ftsZ gene" downshifts 1427504 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR join(1427625,1427632) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs20" N_region 1427626..1427631 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs20" S_feature <1427632..1427677 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1427642..1427649 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1427662..1427681 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1427679 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1427736..1428530 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" /label="ylmA CDS" gene 1427736..1428530 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /label="ylmA gene" promotor_-35 1428448..1428451 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1428466..1428485 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1428474 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="upshifts" misc_RNA 1428543..1428644 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswE RNA" gene 1428543..1428644 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /label="tswE gene" downshifts 1428631 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" /label="downshifts" CDS 1428732..1430012 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" /label="thiQ CDS" gene 1428732..1430012 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /label="thiQ gene" misc_feature complement(1429953..1429969) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1429958) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1430033..1430038 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1430054..1430072 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1430058 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="upshifts" CDS 1430095..1430340 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" /label="ylmC CDS" gene 1430095..1430340 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /label="ylmC gene" promotor_-35 1430256..1430264 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1430275..1430293 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1430283 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1430341..1430451 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1430443..1430462 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1430453 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1430503..1431339 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" /label="ylmD CDS" gene 1430503..1431339 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /label="ylmD gene" CDS 1431346..1432038 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" /label="ylmE CDS" gene 1431346..1432038 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /label="ylmE gene" CDS 1432035..1432490 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" /label="sepF CDS" gene 1432035..1432490 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /label="sepF gene" CDS 1432497..1432769 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" /label="ylmG CDS" gene 1432497..1432769 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /label="ylmG gene" downshifts 1432758 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" CDS 1432830..1433603 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" /label="ylmH CDS" gene 1432830..1433603 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /label="ylmH gene" promotor_-35 1433319..1433326 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1433340..1433358 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1433363 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1433604..1433696 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1433697..1434191 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" /label="divIVA CDS" gene 1433697..1434191 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /label="divIVA gene" promotor_-35 1434204..1434211 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1434225..1434244 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1434232 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1434254..1434480 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /label="iswA RNA" gene 1434254..1434480 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /label="iswA gene" downshifts 1434447 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" /label="downshifts" CDS 1434533..1437298 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" /label="ileS CDS" gene 1434533..1437298 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /label="ileS gene" downshifts 1437289 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(1437344) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" /label="downshifts" promotor_-35 1437379..1437385 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1437400..1437411 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1437400 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="upshifts" CDS 1437443..1437817 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" /label="ylyA CDS" gene 1437443..1437817 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /label="ylyA gene" promotor_-35 1437849..1437853 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1437868 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" promotor_-10 1437869..1437888 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1437920..1438384 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" /label="lspA CDS" gene 1437920..1438384 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /label="lspA gene" CDS 1438386..1439297 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" /label="rluD CDS" gene 1438386..1439297 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /label="rluD gene" promotor_-35 1439292..1439299 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1439314..1439333 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1439328 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" misc_RNA 1439337..1439453 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaA RNA" gene 1439337..1439453 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /label="pyaA gene" CDS 1439480..1440025 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" /label="pyrR CDS" gene 1439480..1440025 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /label="pyrR gene" downshifts complement(1439674) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" /label="downshifts" downshifts 1440016 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" /label="downshifts" misc_RNA 1440029..1440146 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaB RNA" gene 1440029..1440146 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /label="pyaB gene" CDS 1440199..1441506 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" /label="pyrP CDS" gene 1440199..1441506 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /label="pyrP gene" misc_RNA 1441507..1441621 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaC RNA" gene 1441507..1441621 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /label="pyaC gene" CDS 1441652..1442566 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" /label="pyrB CDS" gene 1441652..1442566 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /label="pyrB gene" CDS 1442550..1443836 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" /label="pyrC CDS" gene 1442550..1443836 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /label="pyrC gene" CDS 1443833..1444927 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" /label="pyrAA CDS" gene 1443833..1444927 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /label="pyrAA gene" CDS 1444912..1448127 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" /label="pyrAB CDS" gene 1444912..1448127 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /label="pyrAB gene" CDS 1448124..1448894 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" /label="pyrK CDS" gene 1448124..1448894 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /label="pyrK gene" CDS 1448894..1449829 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" /label="pyrD CDS" gene 1448894..1449829 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /label="pyrD gene" CDS 1449798..1450517 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" /label="pyrF CDS" gene 1449798..1450517 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /label="pyrF gene" CDS 1450496..1451146 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" /label="pyrE CDS" gene 1450496..1451146 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /label="pyrE gene" downshifts 1451148 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" S_feature 1451193..1451265 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1451245..1451252 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1451266..1451285 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1451267 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1451291..1451396 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /label="mswE RNA" gene 1451291..1451396 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /label="mswE gene" S_feature 1451397..1451557 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1451558..1452259 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" /label="cysH CDS" gene 1451558..1452259 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /label="cysH gene" CDS 1452271..1453335 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" /label="cysP CDS" gene 1452271..1453335 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /label="cysP gene" CDS 1453384..1454532 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" /label="sat CDS" gene 1453384..1454532 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /label="sat gene" upshifts complement(1453473) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1453485..1453489) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1453507..1453508) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1454545..1455138 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" /label="cysC CDS" gene 1454545..1455138 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /label="cysC gene" S_feature 1455139..1455236 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1455237..1456010 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" /label="sumT CDS" gene 1455237..1456010 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /label="sumT gene" promotor_-35 1455915..1455922 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1455937..1455956 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1455938 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" CDS 1456013..1456798 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" /label="sirB CDS" gene 1456013..1456798 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /label="sirB gene" CDS 1456779..1457267 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" /label="sirC CDS" gene 1456779..1457267 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /label="sirC gene" downshifts 1457247 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1457294) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1457307..1459025) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" /label="fbnA CDS" gene complement(1457307..1459025) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /label="fbnA gene" promotor_-10 complement(1459047..1459066) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1459061..1459066 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1459061) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1459079..1459084) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1459082..1459100 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1459086 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="upshifts" CDS 1459141..1461813 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" /label="tcaB CDS" gene 1459141..1461813 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /label="tcaB gene" promotor_-10 complement(1460546..1460565) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1460557) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1460580..1460587) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1461819..1461838 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1461822..1461895 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1461822 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1461896..1462771 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" /label="yloC CDS" gene 1461896..1462771 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /label="yloC gene" CDS 1462848..1463117 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" /label="remA CDS" gene 1462848..1463117 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /label="remA gene" misc_feature complement(1462928..1462932) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1462933) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1463125..1463739 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" /label="gmk CDS" gene 1463125..1463739 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /label="gmk gene" CDS 1463743..1463946 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" /label="rpoZ CDS" gene 1463743..1463946 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /label="rpoZ gene" downshifts 1463935 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS 1464027..1465247 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" /label="coaBC CDS" gene 1464027..1465247 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /label="coaBC gene" S_feature complement(1465086..1465661) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1465244..1467661 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" /label="priA CDS" gene 1465244..1467661 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /label="priA gene" promotor_-10 complement(1465657..1465675) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1465661) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1465689..1465695) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1467512..1467516 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1467532..1467551 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1467543 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1467688..1468170 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" /label="defA CDS" gene 1467688..1468170 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /label="defA gene" CDS 1468175..1469128 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" /label="fmt CDS" gene 1468175..1469128 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /label="fmt gene" CDS 1469115..1470458 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" /label="rsmB CDS" gene 1469115..1470458 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /label="rsmB gene" CDS 1470462..1471553 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" /label="rlmN CDS" gene 1470462..1471553 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /label="rlmN gene" CDS 1471560..1472324 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" /label="prpC CDS" gene 1471560..1472324 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /label="prpC gene" downshifts 1471613 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" /label="downshifts" CDS 1472318..1474264 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" /label="prkC CDS" gene 1472318..1474264 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /label="prkC gene" promotor_-35 1474173..1474179 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1474193..1474211 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1474209 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1474279..1475175 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" /label="rsgA CDS" gene 1474279..1475175 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /label="rsgA gene" CDS 1475180..1475833 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " /label="rpe CDS" gene 1475180..1475833 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /label="rpe gene" promotor_-35 1475831..1475840 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1475854..1475873 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1475859 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="upshifts" CDS 1475906..1476550 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" /label="thiN CDS" gene 1475906..1476550 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /label="thiN gene" promotor_-35 1476311..1476317 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1476328 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="upshifts" promotor_-10 1476332..1476350 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1476441..1476446 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1476462..1476480 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1476475 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1476551..1476621 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1476622..1476702 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" /label="spoVM CDS" gene 1476622..1476702 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /label="spoVM gene" downshifts 1476717 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1476762..1477134 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1476775..1476963) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" /label="rpmB CDS" gene complement(1476775..1476963) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /label="rpmB gene" downshifts complement(1476791) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" downshifts complement(1476837) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(1476964..1477056) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1477038..1477057) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1477056) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1477073..1477076) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1477107..1477114 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1477129..1477147 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1477136 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" promotor_-35 1477175..1477178 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1477193..1477212 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1477201 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" CDS 1477240..1477602 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" /label="yloU CDS" gene 1477240..1477602 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /label="yloU gene" downshifts complement(1477453) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1477618..1479279 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" /label="yloV CDS" gene 1477618..1479279 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /label="yloV gene" S_feature 1479280..1479369 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1479342..1479349 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1479363..1479382 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1479371 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="upshifts" CDS 1479418..1480080 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" /label="sdaAB CDS" gene 1479418..1480080 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /label="sdaAB gene" CDS 1480106..1481008 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" /label="sdaAA CDS" gene 1480106..1481008 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /label="sdaAA gene" CDS 1480986..1483034 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" /label="recG CDS" gene 1480986..1483034 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /label="recG gene" promotor_-35 1483070..1483077 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1483092..1483111 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1483098 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1483143..1483709 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" /label="fapR CDS" gene 1483143..1483709 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /label="fapR gene" CDS 1483723..1484724 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " /label="plsX CDS" gene 1483723..1484724 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /label="plsX gene" CDS 1484743..1485696 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" /label="fabD CDS" gene 1484743..1485696 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /label="fabD gene" CDS 1485689..1486429 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" /label="fabG CDS" gene 1485689..1486429 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /label="fabG gene" promotor_-35 1486460..1486464 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1486480..1486499 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1486485 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1486513..1486746 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" /label="acpA CDS" gene 1486513..1486746 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /label="acpA gene" downshifts 1486727 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" promotor_no_box 1486755..1486855 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1486815..1486885 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1486815 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1486886..1487635 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" /label="rnc CDS" gene 1486886..1487635 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /label="rnc gene" downshifts 1487607 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1487677..1487683 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1487695..1487714 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1487717 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1487736..1491296 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" /label="smc CDS" gene 1487736..1491296 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /label="smc gene" S_feature complement(1491230..1492300) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1491316..1492305 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" /label="ftsY CDS" gene 1491316..1492305 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /label="ftsY gene" downshifts 1492292 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1492342..1492827) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" /label="ylqB CDS" gene complement(1492342..1492827) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /label="ylqB gene" downshifts complement(1492345) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1492849..1492867) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1492865) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1492881..1492888) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1492930..1492936 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1492951..1492970 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1492953 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1493004..1493336 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" /label="ylxM CDS" gene 1493004..1493336 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /label="ylxM gene" downshifts complement(1493007) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" /label="downshifts" CDS 1493350..1494690 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" /label="ffh CDS" gene 1493350..1494690 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /label="ffh gene" S_feature 1494691..1494795 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1494796..1495068 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" /label="rpsP CDS" gene 1494796..1495068 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /label="rpsP gene" CDS 1495068..1495313 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" /label="ylqC CDS" gene 1495068..1495313 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /label="ylqC gene" downshifts 1495285 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" S_feature 1495330..1495434 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1495435..1495821 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" /label="ylqD CDS" gene 1495435..1495821 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /label="ylqD gene" CDS 1495826..1496350 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" /label="rimM CDS" gene 1495826..1496350 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /label="rimM gene" CDS 1496347..1497078 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" /label="trmD CDS" gene 1496347..1497078 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /label="trmD gene" promotor_-35 1497084..1497091 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1497105..1497124 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1497109 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" misc_RNA 1497157..1497198 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" /label="L19 leader RNA" gene 1497157..1497198 /locus_tag="BSU_misc_RNA_30" /label="gene" CDS 1497218..1497565 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" /label="rplS CDS" gene 1497218..1497565 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /label="rplS gene" downshifts 1497567 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" /label="downshifts" promotor_-35 1497620..1497626 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1497639..1497707 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1497639 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1497640..1497659 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1497708..1498556 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" /label="rbgA CDS" gene 1497708..1498556 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /label="rbgA gene" promotor_-35 1498577..1498584 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1498597..1498615 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1498607 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1498627..1499394 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" /label="rnhB CDS" gene 1498627..1499394 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /label="rnhB gene" CDS 1499426..1501156 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" /label="ylqG CDS" gene 1499426..1501156 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /label="ylqG gene" upshifts complement(1500663) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1500664..1500683) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1500698..1500705) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1501153..1501434 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" /label="ylqH CDS" gene 1501153..1501434 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /label="ylqH gene" downshifts 1501266 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" /label="downshifts" S_feature 1501435..1501554 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1501526..1501533 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1501547..1501566 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1501556 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1501607..1502764 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" /label="sucC CDS" gene 1501607..1502764 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /label="sucC gene" promotor_no_box complement(1501679..1501779) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1501719) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1502793..1503695 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" /label="sucD CDS" gene 1502793..1503695 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /label="sucD gene" downshifts 1503685 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" /label="downshifts" CDS 1503756..1504649 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" /label="dprA CDS" gene 1503756..1504649 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /label="dprA gene" promotor_-35 1504655..1504662 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1504677..1504696 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1504684..1504836 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1504684 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1504837..1506912 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" /label="topA CDS" gene 1504837..1506912 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /label="topA gene" downshifts 1506882 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 1506944..1506949 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1506956 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1506965..1506983 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1506988..1508295 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" /label="trmFO CDS" gene 1506988..1508295 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /label="trmFO gene" promotor_-35 1508301..1508305 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1508322..1508341 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1508332 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1508363..1509277 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" /label="codV CDS" gene 1508363..1509277 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /label="codV gene" promotor_-35 1508402..1508406 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1508419 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="upshifts" promotor_-10 1508422..1508441 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1509290..1509835 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" /label="clpQ CDS" gene 1509290..1509835 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /label="clpQ gene" CDS 1509852..1511255 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" /label="clpY CDS" gene 1509852..1511255 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /label="clpY gene" CDS 1511295..1512074 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" /label="codY CDS" gene 1511295..1512074 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /label="codY gene" downshifts 1512049 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1512093 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1512194..1512201 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1512214..1512232 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1512225..1512378 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1512225 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1512353..1512360 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1512375..1512394 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1512380 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1512454..1512843 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" /label="flgB CDS" gene 1512454..1512843 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /label="flgB gene" CDS 1512843..1513295 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" /label="flgC CDS" gene 1512843..1513295 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /label="flgC gene" SCAR 1513296..1513297 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_004" CDS 1513352..1514116 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" /label="sigD CDS" gene 1513352..1514116 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /label="sigD gene" promotor_-35 1514126..1514132 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1514145..1514648 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" /label="swrB CDS" gene 1514145..1514648 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /label="swrB gene" promotor_-10 1514147..1514158 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1514161 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1514644..1514650 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1514665..1514684 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1514667..1514791 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1514667 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1514792..1515532 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" /label="rpsB CDS" gene 1514792..1515532 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /label="rpsB gene" downshifts 1515514 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" /label="downshifts" S_feature 1515559..1515633 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1515634..1516515 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" /label="tsf CDS" gene 1515634..1516515 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /label="tsf gene" S_feature 1516516..1516660 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1516661..1517383 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" /label="pyrH CDS" gene 1516661..1517383 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /label="pyrH gene" CDS 1517385..1517942 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" /label="frr CDS" gene 1517385..1517942 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /label="frr gene" downshifts complement(1517889) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" /label="downshifts" promotor_-35 1517931..1517934 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1517949..1517968 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1517967..1518072 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1517967 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1518073..1518855 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" /label="uppS CDS" gene 1518073..1518855 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /label="uppS gene" CDS 1518859..1519668 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" /label="cdsA" gene 1518859..1519668 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /label="cdsA gene" promotor_-35 1519649..1519656 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1519671..1519690 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1519672 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1519730..1520881 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" /label="dxr CDS" gene 1519730..1520881 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /label="dxr gene" CDS 1520888..1522156 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" /label="rasP CDS" gene 1520888..1522156 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /label="rasP gene" CDS 1522189..1523883 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" /label="proS CDS" gene 1522189..1523883 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /label="proS gene" S_feature 1523884..1523991 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1523992..1528305 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" /label="polC CDS" gene 1523992..1528305 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /label="polC gene" S_feature 1528306..1528370 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1528316..1528533 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surG RNA" gene 1528316..1528533 /gene="surG" /locus_tag="BSU_misc_RNA_71" /label="surG gene" promotor_-35 1528342..1528348 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1528363..1528374 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1528372..1528439 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1528372 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="upshifts" promotor_-35 1528422..1528428 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1528441..1528634 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1528441 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="upshifts" promotor_-10 1528442..1528461 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1528635..1529105 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" /label="rimP CDS" gene 1528635..1529105 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /label="rimP gene" downshifts complement(1528956) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1529140..1530255 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" /label="nusA CDS" gene 1529140..1530255 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /label="nusA gene" promotor_no_box complement(1529202..1529302) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1529242) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1530269..1530544 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" /label="rulR CDS" gene 1530269..1530544 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /label="rulR gene" CDS 1530546..1530848 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" /label="rulQ CDS" gene 1530546..1530848 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /label="rulQ gene" CDS 1530868..1533018 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" /label="infB CDS" gene 1530868..1533018 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /label="infB gene" promotor_-35 1532913..1532919 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1532928 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1532934..1532952 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1533015..1533293 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" /label="ylxP CDS" gene 1533015..1533293 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo /label="ylxP gene" CDS 1533310..1533663 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" /label="rbfA CDS" gene 1533310..1533663 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /label="rbfA gene" downshifts 1533654 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" CDS 1533745..1534674 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" /label="truB CDS" gene 1533745..1534674 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /label="truB gene" promotor_-35 1534459..1534466 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1534480..1534499 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1534489 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1534693..1535643 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" /label="ribC CDS" gene 1534693..1535643 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /label="ribC gene" promotor_-35 1535676..1535682 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1535683..1535799 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1535683 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1535697..1535716 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1535800..1536069 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" /label="rpsO CDS" gene 1535800..1536069 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /label="rpsO gene" downshifts 1536052 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" S_feature 1536097..1536182 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1536163..1536166 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1536182..1536201 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1536184 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1536242..1538359 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" /label="pnpA CDS" gene 1536242..1538359 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /label="pnpA gene" downshifts 1538142 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 1538343 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature 1538388..1538476 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1538477..1539436 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" /label="ylxY CDS" gene 1538477..1539436 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /label="ylxY gene" promotor_-10 complement(1538545..1538553) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1538548) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1538567..1538574) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1539040..1539045 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1539061..1539079 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1539066 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1539476..1540705 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" /label="mlpA CDS" gene 1539476..1540705 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /label="mlpA gene" downshifts 1540694 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1540734..1540739 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1540749 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1540755..1540773 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1540783..1541040 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" /label="ymxH CDS" gene 1540783..1541040 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /label="ymxH gene" S_feature 1541041..1541095 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1541068 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1541137..1541146 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1541156..1541225 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1541156 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="upshifts" promotor_-10 1541160..1541179 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1541226..1542119 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" /label="spoVFA CDS" gene 1541226..1542119 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /label="spoVFA gene" CDS 1542122..1542724 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" /label="spoVFB CDS" gene 1542122..1542724 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /label="spoVFB gene" misc_feature 1542778..1542797 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1542778..1542849 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1542778 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1542850..1543890 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" /label="asd CDS" gene 1542850..1543890 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /label="asd gene" S_feature 1543891..1543981 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1543982..1545196 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" /label="dapG CDS" gene 1543982..1545196 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /label="dapG gene" CDS 1545227..1546099 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" /label="dapA CDS" gene 1545227..1546099 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /label="dapA gene" S_feature complement(1545570..1546754) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1546106 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1546199..1546202 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1546216 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1546218..1546237 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1546277..1547944 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" /label="rnjB CDS" gene 1546277..1547944 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /label="rnjB gene" promotor_-10 complement(1546741..1546759) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1546758) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1546775..1546780) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1547932 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1547999..1548005 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1548019..1548030 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1548020 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="upshifts" CDS 1548060..1548797 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" /label="tepA CDS" gene 1548060..1548797 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /label="tepA gene" CDS 1548794..1549006 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" /label="tepJ CDS" gene 1548794..1549006 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /label="tepJ gene" misc_feature 1549034..1549053 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1549048 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="upshifts" CDS 1549137..1551500 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" /label="spoIIIE CDS" gene 1549137..1551500 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /label="spoIIIE gene" S_feature 1551501..1551601 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1551562..1551569 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1551584..1551603 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1551602 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="upshifts" CDS 1551644..1552369 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" /label="ymfC CDS" gene 1551644..1552369 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /label="ymfC gene" downshifts 1552356 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 1552425..1552431 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1552444 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1552446..1552457 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1552508..1553716 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" /label="bcbE CDS" gene 1552508..1553716 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /label="bcbE gene" downshifts 1553674 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1553785..1553792 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1553805..1553824 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1553827 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" promotor_-35 1553839..1553842 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1553858..1553870 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1553872 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1553896..1555176 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" /label="ymfF CDS" gene 1553896..1555176 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /label="ymfF gene" CDS 1555173..1556459 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" /label="ymfH CDS" gene 1555173..1556459 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /label="ymfH gene" downshifts 1556309 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" /label="downshifts" S_feature 1556460..1556513 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1556514..1557242 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" /label="efpI CDS" gene 1556514..1557242 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /label="efpI gene" promotor_-35 1557258..1557264 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1557276 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1557278..1557289 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1557289) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1557300..1557314) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1557323..1557327) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1557323..1557580 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" /label="ymfJ CDS" gene 1557323..1557580 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /label="ymfJ gene" downshifts 1557565 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1557597) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" /label="downshifts" promotor_-35 1557638..1557641 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1557656..1557675 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1557656 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1557710..1558225 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" /label="ymfKn CDS" gene 1557710..1558225 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo /label="ymfKn gene" CDS 1558161..1558499 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" /label="ymfKc CDS" gene 1558161..1558499 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo /label="ymfKc gene" CDS 1558566..1559432 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" /label="rodZ CDS" gene 1558566..1559432 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /label="rodZ gene" promotor_no_box 1558629..1558729 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1558689 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" downshifts 1559392 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1559482..1560063 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" /label="pgsA CDS" gene 1559482..1560063 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /label="pgsA gene" CDS 1560081..1561331 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" /label="cinA CDS" gene 1560081..1561331 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /label="cinA gene" S_feature 1561332..1561458 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1561438..1561445 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1561460..1561479 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1561460 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1561504..1562550 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" /label="recA CDS" gene 1561504..1562550 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /label="recA gene" downshifts 1562562 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 1562607..1562672 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1562644..1562653 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1562666..1562681 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1562674 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1562718..1563893 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " /label="pbpX CDS" gene 1562718..1563893 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /label="pbpX gene" S_feature 1563894..1563993 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1563967..1563974 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1563988..1564007 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1563995..1564168 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1563995 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1564169..1565731 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" /label="rny CDS" gene 1564169..1565731 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /label="rny gene" downshifts 1565708 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" CDS 1565800..1566594 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" /label="pdeB CDS" gene 1565800..1566594 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /label="pdeB gene" promotor_-35 1566349..1566354 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1566370..1566388 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1566390 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="upshifts" promotor_-35 1566638..1566643 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1566654..1566793 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1566654 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="upshifts" promotor_-10 1566659..1566677 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1566686) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1566697..1566710) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1566719..1566723) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1566730) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" /label="downshifts" CDS 1566794..1567054 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" /label="spoVS CDS" gene 1566794..1567054 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /label="spoVS gene" downshifts 1567006 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts complement(1567038) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" /label="downshifts" downshifts 1567050 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1567095..1567269 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1567253..1567260 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1567271 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1567275..1567294 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1567320..1568363 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" /label="tdh CDS" gene 1567320..1568363 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /label="tdh gene" CDS 1568376..1569554 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" /label="kbl CDS" gene 1568376..1569554 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /label="kbl gene" downshifts 1569536 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" promotor_-35 1569634..1569637 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1569646 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1569652..1569671 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1569702..1571231 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" /label="miaB CDS" gene 1569702..1571231 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /label="miaB gene" CDS 1571233..1571664 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" /label="ricA CDS" gene 1571233..1571664 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /label="ricA gene" downshifts 1571647 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1571795..1571800 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1571816..1571834 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1571824..1571925 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1571824 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="upshifts" CDS 1571926..1572471 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" /label="cotE CDS" gene 1571926..1572471 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /label="cotE gene" downshifts 1572465 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" /label="downshifts" downshifts complement(1572472) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" /label="downshifts" promotor_-35 1572529..1572532 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1572547..1572566 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1572551 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="upshifts" CDS 1572604..1575180 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" /label="mutS CDS" gene 1572604..1575180 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /label="mutS gene" CDS 1575196..1577079 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" /label="mutL CDS" gene 1575196..1577079 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /label="mutL gene" S_feature complement(1576982..>1577114) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /modified_by="User" /label="S611" downshifts 1576994 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1577004) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(1577114,1577121) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_028" N_region 1577115..1577120 /note="EcoRI site (GAATTC)" /created_by="User" /modified_by="User" /label="IIG_Bs27_028" CDS complement(1577119..1577379) /gene="ymaG" /locus_tag="PG10_pseudo_BSU_17310" /old_locus_tag="BSU_17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /modified_by="User" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAP*" /label="PG10_pseudo_BSU_17310" gene complement(1577119..1577379) /gene="ymaG" /locus_tag="PG10_pseudo_BSU_17310" /old_locus_tag="BSU_17310" /modified_by="User" /label="PG10_pseudo_BSU_17310" promotor_-35 1577375..1577380 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1577396..1577414 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1577406..1577425) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1577416 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="upshifts" upshifts complement(1577419) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1577438..1577447) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1577468..1577881 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" /label="ymaF CDS" gene 1577468..1577881 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /label="ymaF gene" upshifts 1577932 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="upshifts" misc_feature 1577938..1577957 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1577981..1578925 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" /label="miaA CDS" gene 1577981..1578925 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /label="miaA gene" promotor_-35 1578905..1578913 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1578924..1578942 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1578926 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="upshifts" CDS 1578965..1579186 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" /label="hfq CDS" gene 1578965..1579186 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /label="hfq gene" downshifts complement(1578976) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1579038..1579042) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1579042) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1579057..1579062) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1579186 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1579382..1579654 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" /label="ymzC CDS" gene 1579382..1579654 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /label="ymzC gene" promotor_-35 1579670..1579677 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1579691..1579710 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1579693 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="upshifts" CDS 1579736..1579966 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" /label="ymzA CDS" gene 1579736..1579966 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /label="ymzA gene" S_feature 1579967..1580043 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1580000 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 1580045..1580152 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1580125..1580132 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1580146..1580165 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1580154 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="upshifts" CDS 1580209..1580601 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" /label="nrdI CDS" gene 1580209..1580601 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /label="nrdI gene" CDS 1580561..1582663 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" /label="nrdE CDS" gene 1580561..1582663 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /label="nrdE gene" CDS 1582681..1583670 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" /label="nrdF CDS" gene 1582681..1583670 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /label="nrdF gene" downshifts 1583630 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(1583684..1584343) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1583699) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 1583720..1584340 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" /label="ymaB CDS" gene 1583720..1584340 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /label="ymaB gene" downshifts 1584321 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" /label="downshifts" promotor_-35 1584356..1584360 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1584378..1584745 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1584378 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1584382..1584399 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1584388) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS complement(1584404..1585171) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" /label="cwlC CDS" gene complement(1584404..1585171) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /label="cwlC gene" promotor_-10 complement(1585180..1585199) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1585203) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1585212..1585221) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1585325..1585330 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1585346..1585364 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1585346 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1585628..1585633 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1585650..1585668 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1585654..1585794 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1585654 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="upshifts" CDS 1585795..1586763 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" /label="spoVK CDS" gene 1585795..1586763 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /label="spoVK gene" downshifts 1586732 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-35 1586827..1586835 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1586842 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="upshifts" promotor_-10 1586846..1586865 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1586896..1588158 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" /label="hflX CDS" gene 1586896..1588158 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /label="hflX gene" CDS 1588176..1589441 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" /label="ynbB CDS" gene 1588176..1589441 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /label="ynbB gene" promotor_-35 1589489..1589496 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1589511..1589530 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1589523 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="upshifts" CDS 1589551..1589958 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" /label="glnR CDS" gene 1589551..1589958 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /label="glnR gene" downshifts complement(1589557) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" /label="downshifts" misc_feature 1589939..1589957 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1589964 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1590017) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" /label="downshifts" CDS 1590017..1591351 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" /label="glnA CDS" gene 1590017..1591351 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /label="glnA gene" downshifts 1591328 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature 1591373..>1591422 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" SCAR 1591422..1591423 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs04" S_feature <1591423..1592175 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1591515..1591533) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1591533) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1591549..1591554) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1592176..1593567 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" /label="xynP CDS" gene 1592176..1593567 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /label="xynP gene" CDS 1593598..1595199 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" /label="xynB CDS" gene 1593598..1595199 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /label="xynB gene" S_feature complement(1593714..1594019) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1594014..1594033) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1594019) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1594047..1594055) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1595197 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" /label="downshifts" CDS complement(1595336..1596490) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" /label="xylR CDS" gene complement(1595336..1596490) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /label="xylR gene" downshifts complement(1595339) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1596389..1596567) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1596535..1596541 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1596550..1596569) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1596551..1596567 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1596561 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1596567) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1596584..1596587) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1596594..1596601 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1596616..1596635 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1596627..1596731 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1596628 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="upshifts" CDS 1596732..1598069 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" /label="xylA CDS" gene 1596732..1598069 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /label="xylA gene" S_feature 1598070..1598144 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1598101 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" CDS 1598220..1599719 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" /label="xylB CDS" gene 1598220..1599719 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /label="xylB gene" S_feature 1599720..1600035 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1599993 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1600202..1600837) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" /label="yncB CDS" gene complement(1600202..1600837) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /label="yncB gene" promotor_-10 complement(1600874..1600893) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1600883) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1600908..1600915) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1601025..1601032 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1601047..1601066 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1601049..1601247 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1601049 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="upshifts" CDS 1601248..1602663 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" /label="yncC CDS" gene 1601248..1602663 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /label="yncC gene" downshifts 1602653 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1602756) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1602765..1603949) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" /label="alrB CDS" gene complement(1602765..1603949) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /label="alrB gene" S_feature complement(1603950..1604029) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1604022..1604040) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1604033) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1604056..1604061) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1604341..1604348 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1604363..1604382 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1604371 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1604413..1604874 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" /label="yncE CDS" gene 1604413..1604874 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /label="yncE gene" CDS 1604904..1605338 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" /label="dutA CDS" gene 1604904..1605338 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /label="dutA gene" S_feature complement(1605087..1605392) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1605185 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" S_feature 1605339..1606435 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1605394..1605679) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1605437) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1605674..1605693) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1605679) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1605705..1605710) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1605941) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1605941..1606201) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" /label="cotU CDS" gene complement(1605941..1606201) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /label="cotU gene" promotor_-10 complement(1606222..1606241) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1606232) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1606254..1606263) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1606436..1606561 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" /label="ynzJ CDS" gene 1606436..1606561 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo /label="ynzJ gene" S_feature 1606562..1606678 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1606605..1606769 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" /label="conserved hypothetical protein from phage origin CDS" gene 1606605..1606769 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /label="gene" promotor_-35 1606653..1606662 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1606676..1606695 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1606680..1606990 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1606680 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1606971..1606978 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1606992..1607011 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1606992 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1607043..1607882 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" /label="thyA CDS" gene 1607043..1607882 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /label="thyA gene" promotor_-10 complement(1607065..1607084) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1607086) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1607099..1607102) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1607842 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts complement(1607988) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature complement(1607989..1608295) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1608005..1608292) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" /label="conserved protein of unknown function CDS" gene complement(1608005..1608292) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /label="gene" downshifts complement(1608032) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1608119..1608127 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1608141..1608160 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1608143 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="upshifts" S_feature 1608154..1608314 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1608286 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1608335..1609057) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" /label="yncM CDS" gene complement(1608335..1609057) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /label="yncM gene" downshifts complement(1608340) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1609082..1609101) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1609090) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1609092..1609216) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1609217..1609573) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" /label="ynzK CDS" gene complement(1609217..1609573) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /label="ynzK gene" promotor_-10 complement(1609597..1609616) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1609614) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1609632..1609636) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1609813) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1609819..1610019) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" /label="cotC CDS" gene complement(1609819..1610019) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /label="cotC gene" downshifts 1610002 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1610041..1610060) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1610053) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1610073..1610082) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1610194..1610382) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" /label="tatAC CDS" gene complement(1610194..1610382) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /label="tatAC gene" downshifts complement(1610210) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" misc_feature complement(1610351..1610358) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1610364) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1610411..1610430) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1610429) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1610445..1610452) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1610461..1610598 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" /label="hypothetical protein CDS" gene 1610461..1610598 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /label="gene" promotor_-35 1610492..1610497 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1610512..1610530 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1610530..1610632 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1610530 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="upshifts" CDS 1610633..1611031 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" /label="yndA CDS" gene 1610633..1611031 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /label="yndA gene" S_feature 1611032..1611836 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1611096..1611530) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" /label="flvS CDS" gene complement(1611096..1611530) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /label="flvS gene" downshifts complement(1611112) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1611560..1611579) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1611576) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1611593..1611600) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1611837..1612025 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" /label="ynzB CDS" gene 1611837..1612025 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /label="ynzB gene" S_feature 1612026..1612111 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1612070 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1612140..1612146 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1612158..1612317 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1612158 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1612160..1612171 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1612318..1613880 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" /label="yndD CDS" gene 1612318..1613880 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /label="yndD gene" promotor_-10 complement(1612621..1612640) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1612630) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1612655..1612662) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1613910..1615001 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" /label="yndE CDS" gene 1613910..1615001 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /label="yndE gene" CDS 1614991..1616205 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" /label="yndF CDS" gene 1614991..1616205 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /label="yndF gene" promotor_-35 1616283..1616290 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1616305..1616324 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1616316 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="upshifts" CDS 1616352..1617158 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" /label="yndG CDS" gene 1616352..1617158 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /label="yndG gene" S_feature complement(1616966..1618064) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1617163..1617780 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" /label="yndH CDS" gene 1617163..1617780 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /label="yndH gene" CDS 1617777..1619417 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" /label="yndJ CDS" gene 1617777..1619417 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /label="yndJ gene" promotor_-10 complement(1618051..1618070) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1618064) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1618084..1618092) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1619057..1619823) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1619454..1619819 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" /label="yndK CDS" gene 1619454..1619819 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /label="yndK gene" downshifts 1619796 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1619816..1620096) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surA RNA" gene complement(1619816..1620096) /gene="surA" /locus_tag="BSU_misc_RNA_72" /label="surA gene" S_feature complement(1619825..1619956) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1619868) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1619916..1619925 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1619938..1619947) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1619939..1619958 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1619944 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" S_feature 1619946..1620044 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1619956) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1619958..1620088) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1620045..1620803 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" /label="pghL CDS" gene 1620045..1620803 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /label="pghL gene" upshifts 1620078 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1620094..1620113) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1620095) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1620128..1620135) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1620618..1620829) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1620782 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" S_feature 1620827..1621446 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1620830..1621369) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" /label="yndM CDS" gene complement(1620830..1621369) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /label="yndM gene" promotor_-10 complement(1621370..1621384) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1621376) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1621398..1621404) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1621424..1621433 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1621446..1621461 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1621448 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" CDS 1621487..1621921 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" /label="fosB CDS" gene 1621487..1621921 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /label="fosB gene" CDS 1621779..1622126 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" /label="yzzP CDS" gene 1621779..1622126 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /label="yzzP gene" S_feature 1621922..1622254 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1622213..1622222 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1622234..1622249 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1622256..1622434 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1622256 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1622325..1622404 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="ncrF RNA" gene 1622325..1622404 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /label="ncrF gene" downshifts 1622391 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1622463..1623080) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" /label="lexA CDS" gene complement(1622463..1623080) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /label="lexA gene" downshifts complement(1622464) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1623104..1623123) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1623125) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1623137..1623144) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1623160..1623167 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1623179 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1623181..1623200 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1623230..1623547 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" /label="dinK CDS" gene 1623230..1623547 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /label="dinK gene" promotor_-10 complement(1623247..1623265) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1623250) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1623279..1623286) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1623566..1624219 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " /label="dinL CDS" gene 1623566..1624219 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /label="dinL gene" promotor_-35 1624222..1624229 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1624243..1624262 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1624256 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="upshifts" CDS 1624283..1624516 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" /label="ynzC CDS" gene 1624283..1624516 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /label="ynzC gene" S_feature 1624517..1624652 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1624620..1624627 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1624641..1624660 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1624654 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="upshifts" CDS 1624685..1626688 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" /label="tktA CDS" gene 1624685..1626688 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /label="tktA gene" misc_feature complement(1624889..1624908) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1624906) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1626678 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1626690..1627348) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1626788 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="upshifts" misc_feature 1626789..1626808 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1626841..1627287 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" /label="pcfA CDS" gene 1626841..1627287 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /label="pcfA gene" misc_feature 1627311..1627330 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1627319 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1627330..1627347) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1627348) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1627366..1627370) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1627373..1627591 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" /label="yneF CDS" gene 1627373..1627591 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /label="yneF gene" downshifts 1627603 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" /label="downshifts" S_feature 1627648..1627947 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1627665..1627838) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" /label="spo0D CDS" gene complement(1627665..1627838) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /label="spo0D gene" downshifts complement(1627678) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1627876..1627895) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1627883) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1627909..1627916) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1627918..1627926 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1627938..1627957) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1627938..1627956 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1627949..1628057 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1627949 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1627950) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1627972..1627979) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1628058..1628765 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" /label="ccdA CDS" gene 1628058..1628765 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /label="ccdA gene" promotor_-35 1628785..1628792 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1628804..1628823 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1628812 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1628854..1629216 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" /label="yneI CDS" gene 1628854..1629216 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /label="yneI gene" promotor_-35 1629234..1629237 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1629252..1629271 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1629263 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1629295..1629786 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" /label="yneJ CDS" gene 1629295..1629786 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /label="yneJ gene" downshifts 1629782 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1629817..1630245) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" /label="yneK CDS" gene complement(1629817..1630245) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /label="yneK gene" downshifts complement(1629834) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1630263..1630282) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1630275) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1630277..1630362) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1630296..1630303) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1630333..1630342 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1630352..1630461 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1630352 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1630355..1630374 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1630357..1630376) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1630362) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1630364..1630447) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1630391..1630394) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1630418 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1630479..1630871) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" /label="cotM CDS" gene complement(1630479..1630871) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /label="cotM gene" downshifts complement(1630492) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" /label="downshifts" promotor_-35 1630714..1630719 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1630735..1630753 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1630739 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="upshifts" promotor_-35 1630849..1630853 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1630863..1630877 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1630878..1630897) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1630880 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1630893) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1630911..1630920) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1630952..1631098) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" /label="sspP CDS" gene complement(1630952..1631098) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /label="sspP gene" downshifts complement(1630973) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1631130..1631276) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" /label="sspO CDS" gene complement(1631130..1631276) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /label="sspO gene" S_feature 1631276..1631409 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1631276 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1631287..1631289 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1631292..1631303) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1631306) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1631318..1631324) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1631399..1631406 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1631411..1631503 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1631411 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1631421..1631440 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1631462) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1631504..1634233 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" /label="citB CDS" gene 1631504..1634233 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /label="citB gene" misc_feature complement(1631524..1631528) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1631528) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1634234..1634304 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1634305..1634817 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" /label="yneN CDS" gene 1634305..1634817 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /label="yneN gene" downshifts 1634774 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-35 1634843..1634849 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1634862 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1634864..1634875 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1634898..1635023 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" /label="ynzL CDS" gene 1634898..1635023 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /label="ynzL gene" downshifts complement(1634916) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" /label="downshifts" promotor_-35 1635037..1635043 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1635058..1635069 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1635060 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" CDS 1635088..1635234 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" /label="sspN CDS" gene 1635088..1635234 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /label="sspN gene" CDS 1635271..1635522 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" /label="sspT CDS" gene 1635271..1635522 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /label="sspT gene" downshifts 1635500 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1635543..1635548 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1635562..1635581 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1635566..1635657 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1635566 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1635658..1636023 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" /label="yneP CDS" gene 1635658..1636023 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /label="yneP gene" CDS 1636039..1636338 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" /label="yneQ CDS" gene 1636039..1636338 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /label="yneQ gene" downshifts 1636314 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1636369..1636656) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" /label="yneR CDS" gene complement(1636369..1636656) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /label="yneR gene" downshifts complement(1636390) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(1636456) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1636686..1636705) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1636698) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1636721..1636728) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1636744..1637325) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" /label="plsY CDS" gene complement(1636744..1637325) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /label="plsY gene" S_feature 1637326..1637456 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1637351..1637370) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1637368) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1637441..1637444 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1637458 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1637460..1637479 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1637495..1637902 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" /label="yneT CDS" gene 1637495..1637902 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /label="yneT gene" downshifts 1637898 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" /label="downshifts" promotor_-35 1637964..1637967 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1637982..1638001 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1637986..1638300 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1637986 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" CDS 1638301..1640268 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" /label="parE CDS" gene 1638301..1640268 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /label="parE gene" CDS 1640272..1642692 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" /label="parC CDS" gene 1640272..1642692 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /label="parC gene" downshifts 1642672 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1642700..1642889) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1642739..1642915) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" /label="ynfCc CDS" gene complement(1642739..1642915) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo /label="ynfCc gene" downshifts complement(1642743) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1642890..1643300) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" /label="ynfCn CDS" gene complement(1642890..1643300) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo /label="ynfCn gene" promotor_-10 complement(1643273..1643292) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1643276) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1643307..1643314) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1643341..1643360) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1643342) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1643375..1643382) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1643389..1643408) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1643400) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1643422..1643431) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1643648..1643653 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1643666..1643685 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1643671 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="upshifts" S_feature 1643684..1643748 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1643749..1645146 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" /label="alsT CDS" gene 1643749..1645146 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /label="alsT gene" downshifts 1645135 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 1645180 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(1645236..1645982) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1645359..1645366 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1645378 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1645379..1645398 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1645449..1646948 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" /label="eglS CDS" gene 1645449..1646948 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /label="eglS gene" promotor_-10 complement(1645981..1646000) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1646004) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1646014..1646023) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1646896 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1647016..1647279 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" /label="ynfE CDS" gene 1647016..1647279 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /label="ynfE gene" downshifts complement(1647538) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1647538..1648806) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" /label="xynC CDS" gene complement(1647538..1648806) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /label="xynC gene" S_feature complement(1648807..1648936) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1648937..1650478) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" /label="xynD CDS" gene complement(1648937..1650478) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /label="xynD gene" S_feature complement(1650479..1650800) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1650790..1650809) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1650801) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1650824..1650827) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1651027..1651034 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1651047..1651066 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1651054 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1651073..1651519 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" /label="yngA CDS" gene 1651073..1651519 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /label="yngA gene" CDS 1651526..1652419 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" /label="yngB CDS" gene 1651526..1652419 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /label="yngB gene" misc_feature 1652036..1652055 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1652044 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="upshifts" CDS 1652492..1653088 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" /label="yngC CDS" gene 1652492..1653088 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /label="yngC gene" downshifts 1653078 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1653137..1654336) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" /label="nrnB CDS" gene complement(1653137..1654336) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /label="nrnB gene" S_feature complement(1654337..1654408) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1654396..1654407) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1654408) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1654422..1654428) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1654506..1656041) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" /label="ldeE CDS" gene complement(1654506..1656041) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /label="ldeE gene" downshifts complement(1654518) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1656052..1656834) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" /label="ldeF CDS" gene complement(1656052..1656834) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /label="ldeF gene" CDS complement(1656855..1657754) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" /label="ldeG CDS" gene complement(1656855..1657754) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /label="ldeG gene" CDS complement(1657769..1657990) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" /label="lgeHB CDS" gene complement(1657769..1657990) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /label="lgeHB gene" CDS complement(1658005..1659339) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" /label="ldeHA CDS" gene complement(1658005..1659339) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /label="ldeHA gene" CDS complement(1659349..1660998) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" /label="ldeI CDS" gene complement(1659349..1660998) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /label="ldeI gene" promotor_no_box 1659398..1659498 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1659458 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1661042..1662184) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" /label="ldeJ CDS" gene complement(1661042..1662184) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /label="ldeJ gene" promotor_-10 complement(1662203..1662221) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1662220) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1662237..1662242) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1662275..1662580) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " /label="ynzE CDS" gene complement(1662275..1662580) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /label="ynzE gene" CDS complement(1662570..1662743) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" /label="conserved protein of unknown function CDS" gene complement(1662570..1662743) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /label="gene" CDS complement(1662851..1664383) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" /label="yngK CDS" gene complement(1662851..1664383) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /label="yngK gene" downshifts complement(1662862) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1664418..1664437) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1664418) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1664450..1664459) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1664519..1664911) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" /label="yngL CDS" gene complement(1664519..1664911) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /label="yngL gene" downshifts complement(1664550) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1664939..1664950) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1664946) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1664964..1664970) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1665018,1665025) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs10" N_region 1665019..1665024 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs10" S_feature complement(<1665025..1665130) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1665115..1665134) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1665130) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1665148..1665155) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1665404..1666879) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" /label="dacC CDS" gene complement(1665404..1666879) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /label="dacC gene" downshifts complement(1665416) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(1666913..1667890) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" /label="galM CDS" gene complement(1666913..1667890) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /label="galM gene" promotor_-10 complement(1667919..1667937) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1667931) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1667949..1667957) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1668024..1669415) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" /label="yoeA CDS" gene complement(1668024..1669415) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /label="yoeA gene" downshifts complement(1668038) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" /label="downshifts" downshifts 1668184 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" promotor_-35 1669205..1669211 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 1669225..1669243 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 1669236..1669569 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 1669236 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="upshifts" S_feature complement(1669416..1669520) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(1669480..1669580) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1669520) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1669542..1669547 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1669563..1669581 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1669571 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1669629..1669636 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1669649..1669668 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1669652 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" CDS 1669701..1670246 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" /label="iseA CDS" gene 1669701..1670246 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /label="iseA gene" downshifts 1670230 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA complement(1670340..1670412) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg1 tRNA" gene complement(1670340..1670412) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /label="trnSL-Arg1 gene" downshifts complement(1670438) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1670465..1671010) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" /label="yoeC CDS" gene complement(1670465..1671010) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /label="yoeC gene" promotor_-10 complement(1671050..1671069) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1671064) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1671083..1671090) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1671326..1671556) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" /label="yoeD CDS" gene complement(1671326..1671556) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /label="yoeD gene" downshifts complement(1671340) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1671582..1671601) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1671594) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1671613..1671619) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1671648..1671667) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1671658) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1671671..1671678 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1671692..1671711 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1671696 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="upshifts" CDS 1671741..1673504 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" /label="ggt CDS" gene 1671741..1673504 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /label="ggt gene" downshifts 1673485 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1673605..1674462) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" /label="ftsR CDS" gene complement(1673605..1674462) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /label="ftsR gene" promotor_-10 complement(1674508..1674527) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1674528) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1674541..1674548) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1674590..1675579 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" /label="yogA CDS" gene 1674590..1675579 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /label="yogA gene" S_feature complement(1674646..1675604) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(1675636..1677117) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" /label="gltB CDS" gene complement(1675636..1677117) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /label="gltB gene" downshifts complement(1675649) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" /label="downshifts" CDS complement(1677134..1681696) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" /label="gltA CDS" gene complement(1677134..1681696) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /label="gltA gene" promotor_no_box 1680157..1680257 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1680217 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1681697..1681768) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(1681748..1681767) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1681765..1681772 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1681768) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1681782..1681789) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1681784 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1681787..1681806 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1681843..1682745 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" /label="gltC CDS" gene 1681843..1682745 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /label="gltC gene" downshifts 1682725 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1682797..1683912) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" /label="proJ CDS" gene complement(1682797..1683912) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /label="proJ gene" CDS complement(1683909..1684802) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" /label="proH CDS" gene complement(1683909..1684802) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /label="proH gene" promotor_-10 complement(1684807..1684826) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1684815 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" upshifts complement(1684825) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1684840..1684846) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1684855..1684873) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1684873) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1684889..1684894) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1684950..1685318) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" /label="rtp CDS" gene complement(1684950..1685318) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /label="rtp gene" promotor_-10 complement(1685353..1685371) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(1685376) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="upshifts" S_feature complement(1685378..1685497) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(1685383..1685391) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(1685489..1685508) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1685497) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1685499..1685595) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(1685523..1685530) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1685618..1686334) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" /label="yoxD CDS" gene complement(1685618..1686334) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /label="yoxD gene" downshifts complement(1685640) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1686372..1686391) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1686381) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1686407..1686410) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1686435..1686441 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1686455..1686473 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1686460 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="upshifts" CDS 1686485..1686790 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " /label="yoxC CDS" gene 1686485..1686790 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /label="yoxC gene" downshifts 1686774 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" /label="downshifts" CDS 1686861..1687631 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" /label="yoxB CDS" gene 1686861..1687631 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /label="yoxB gene" promotor_-35 1687613..1687620 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1687632 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1687635..1687654 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1687675..1688208 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" /label="yoaA CDS" gene 1687675..1688208 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /label="yoaA gene" S_feature 1688209..1688294 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 1688251 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1688287..1689531) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" /label="yoaB CDS" gene complement(1688287..1689531) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /label="yoaB gene" S_feature 1688296..1689035 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(1688301) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1689532..1689624) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(1689625..1691088) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" /label="yoaC CDS" gene complement(1689625..1691088) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /label="yoaC gene" CDS complement(1691106..1692140) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" /label="yoaD CDS" gene complement(1691106..1692140) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /label="yoaD gene" S_feature complement(1692152..1692223) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(1692195) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1692224..1692315) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswF RNA" gene complement(1692224..1692315) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /label="mswF gene" promotor_-10 complement(1692343..1692362) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1692355) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1692377..1692384) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1692397..1692404 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1692418..1692437 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1692422 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="upshifts" CDS 1692464..1694506 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" /label="yoaE CDS" gene 1692464..1694506 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /label="yoaE gene" promotor_-35 1694514..1694523 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1694536..1694551 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1694539 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1694573..1694866 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" /label="yoaF CDS" gene 1694573..1694866 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /label="yoaF gene" downshifts 1694846 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1694891..1695238) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(1694922) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1695239..1695643) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" /label="yoaG CDS" gene complement(1695239..1695643) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /label="yoaG gene" S_feature complement(1695644..1695739) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(1695729..1695744) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1695729..1695848) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" /label="hypothetical protein CDS" gene complement(1695729..1695848) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /label="gene" upshifts complement(1695739) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1695757..1695766) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1695844..1695850 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1695864..1695875 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1695875..1696083 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 1695875 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1695918..1696040 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" /label="conserved hypothetical protein CDS" gene 1695918..1696040 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /label="gene" CDS 1696084..1696377 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" /label="yozQ CDS" gene 1696084..1696377 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /label="yozQ gene" S_feature 1696378..1696471 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 1696428 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1696493..1698178) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" /label="yoaH CDS" gene complement(1696493..1698178) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /label="yoaH gene" downshifts complement(1696505) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(1698179..1698266) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(1698258..1698276) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1698266) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1698290..1698297) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1698435..1698444 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1698454 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1698457..1698476 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1698503..1699954 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" /label="yoaI CDS" gene 1698503..1699954 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /label="yoaI gene" downshifts 1699930 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1699991..1700689) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" /label="exlX CDS" gene complement(1699991..1700689) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /label="exlX gene" downshifts complement(1700006) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1700724..1700743) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1700743) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1700745..1700958) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(1700757..1700764) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1700959..1701636) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" /label="yoaK CDS" gene complement(1700959..1701636) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /label="yoaK gene" S_feature complement(1701637..1704126) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 1701809..1702846 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" /label="pelB CDS" gene 1701809..1702846 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /label="pelB gene" promotor_-35 1703043..1703049 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1703064..1703075 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1703076 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1703103..1703786 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" /label="yoaM CDS" gene 1703103..1703786 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /label="yoaM gene" CDS complement(1704127..1704432) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " /label="yozS CDS" gene complement(1704127..1704432) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /label="yozS gene" S_feature complement(1704433..1704534) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(1704513..1704532) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1704534) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1704547..1704554) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1704562..1704664) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(1704604) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1704665..1705843) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" /label="oxdD CDS" gene complement(1704665..1705843) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /label="oxdD gene" promotor_-10 complement(1705869..1705888) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1705888) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1705902..1705911) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1705966..1706454) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" /label="yoaO CDS" gene complement(1705966..1706454) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /label="yoaO gene" downshifts complement(1705991) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" /label="downshifts" CDS complement(1706479..1706634) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" /label="hypothetical protein CDS" gene complement(1706479..1706634) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /label="gene" CDS complement(1706674..1707429) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" /label="yoaP CDS" gene complement(1706674..1707429) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /label="yoaP gene" promotor_-35 1707682..1707687 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1707703..1707721 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1707718 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="upshifts" CDS 1707737..1708093 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" /label="yoaQ CDS" gene 1707737..1708093 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /label="yoaQ gene" CDS complement(1708052..1708291) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" /label="yozT CDS" gene complement(1708052..1708291) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /label="yozT gene" S_feature 1708094..1708530 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(1708292..1708393) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(1708394..1708891) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" /label="yozF CDS" gene complement(1708394..1708891) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /label="yozF gene" S_feature complement(1708892..1708991) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(1708992..1709903) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" /label="yoaR CDS" gene complement(1708992..1709903) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /label="yoaR gene" promotor_-10 complement(1709925..1709936) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1709927) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1709951..1709957) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1710187..1710194 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1710203 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1710209..1710228 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1710250..1710732 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" /label="yoaS CDS" gene 1710250..1710732 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /label="yoaS gene" CDS 1710742..1710996 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" /label="yozG CDS" gene 1710742..1710996 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /label="yozG gene" S_feature 1710997..1711101 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 1711102..1711896 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" /label="yoaT CDS" gene 1711102..1711896 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /label="yoaT gene" S_feature 1711897..1712907 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(1712020..1712892) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" /label="yoaU CDS" gene complement(1712020..1712892) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /label="yoaU gene" CDS 1712993..1713871 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" /label="yoaV CDS" gene 1712993..1713871 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /label="yoaV gene" S_feature complement(1713984..1714043) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(1714019) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1714044..1714475) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" /label="yoaW CDS" gene complement(1714044..1714475) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /label="yoaW gene" promotor_-10 complement(1714495..1714514) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1714503) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1714505..1714738) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(1714528..1714534) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1714739..1714757) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1714739..1715371) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" /label="yoaZ CDS" gene complement(1714739..1715371) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /label="yoaZ gene" upshifts complement(1714745) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1714773..1714778) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1715509..1715516 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1715531..1715550 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1715535 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="upshifts" CDS 1715597..1716517 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" /label="penP CDS" gene 1715597..1716517 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /label="penP gene" promotor_-10 complement(1716028..1716047) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1716043) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1716062..1716069) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1716518..1717175 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(1717014..1717376) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" /label="yobA CDS" gene complement(1717014..1717376) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /label="yobA gene" CDS complement(1717437..1717649) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" /label="yozU CDS" gene complement(1717437..1717649) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo /label="yozU gene" promotor_-35 1717688..1717695 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1717710..1717729 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1717713 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="upshifts" CDS 1717753..1718016 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" /label="yobB CDS" gene 1717753..1718016 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /label="yobB gene" downshifts 1717994 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1718393..1720993) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" /label="yppS CDS" gene complement(1718393..1720993) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /label="yppS gene" S_feature complement(1720994..1721103) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 1721019..1721026 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1721041..1721060 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1721049..1721676 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 1721049 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1721093..1721112) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1721103) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1721127..1721133) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1721149..1721608) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(1721191) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1721653) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(1721663..1722304) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" /label="xynA CDS" gene complement(1721663..1722304) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /label="xynA gene" S_feature complement(1722305..1722422) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(1722399..1722418) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1722422) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1722432..1722434) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1722510,1722517) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs05" N_region 1722511..1722516 /note="SacI site (GAGCTC)" /modified_by="User" /label="IIG_Bs05" misc_RNA <1722517..1722601 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" /label="bsrF RNA" S_feature <1722517..1722594 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" S_feature complement(<1722517..1722581) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" gene <1722517..1722601 /gene="bsrF" /old_locus_tag="BSU_misc_RNA_75" /locus_tag="PG10_pseudo_BSU_misc_RNA_75" /modified_by="User" /label="PG10_pseudo_BSU_misc_RNA_75" downshifts 1722579 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1722612..1722944) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" /label="csaA CDS" gene complement(1722612..1722944) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /label="csaA gene" downshifts complement(1722626) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1723009..1723734) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" /label="yobQ CDS" gene complement(1723009..1723734) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /label="yobQ gene" CDS complement(1723749..1724492) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" /label="yobR CDS" gene complement(1723749..1724492) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /label="yobR gene" promotor_-10 complement(1724520..1724539) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1724539) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1724553..1724559) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1724570..1725145) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" /label="yobS CDS" gene complement(1724570..1725145) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /label="yobS gene" CDS complement(1725151..1725852) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" /label="yobT CDS" gene complement(1725151..1725852) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /label="yobT gene" promotor_-10 complement(1725882..1725901) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1725882) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1725886..1725901) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1725916..1725923) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1725916..1725923) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1725926) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1725929..1726411) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" /label="yobU CDS" gene complement(1725929..1726411) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /label="yobU gene" misc_feature complement(1726450..1726467) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1726454) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1726465..1727406) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" /label="yobV CDS" gene complement(1726465..1727406) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /label="yobV gene" downshifts complement(1726498) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1727436..1727455) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1727444) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1727469..1727473) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1727477..1727486 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1727499..1727518 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1727507 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="upshifts" S_feature 1727522..1727586 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 1727558..1727563 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1727579..1727597 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1727588 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="upshifts" CDS 1727612..1728157 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" /label="yobW CDS" gene 1727612..1728157 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /label="yobW gene" downshifts 1728116 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS complement(1728184..1728507) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" /label="czrA CDS" gene complement(1728184..1728507) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /label="czrA gene" downshifts complement(1728191) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1728528..1728547) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1728539) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1728560..1728567) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1728628..1728634 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1728645 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1728649..1728668 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1728701..1729378 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" /label="yocA CDS" gene 1728701..1729378 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /label="yocA gene" downshifts 1729370 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1729468..1730004) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" /label="yozB CDS" gene complement(1729468..1730004) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /label="yozB gene" downshifts complement(1729491) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1730031..1730050) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1730051) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1730064..1730071) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1730141..1730923) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" /label="yocB CDS" gene complement(1730141..1730923) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /label="yocB gene" downshifts complement(1730150) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1730945..1730963) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1730964) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1730977..1730983) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1731020..1731027 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1731042..1731061 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1731046 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1731094..1731591 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" /label="yocC CDS" gene 1731094..1731591 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /label="yocC gene" promotor_-35 1731598..1731601 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1731617..1731636 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1731619 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1731655..1732632 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" /label="yocD CDS" gene 1731655..1732632 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /label="yocD gene" downshifts 1732604 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 1732729..1732736 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1732751..1732770 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1732758 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1732794..1733852 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" /label="desE CDS" gene 1732794..1733852 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /label="desE gene" S_feature 1733853..1733922 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 1733906..1733912 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1733924..1733943 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1733924 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1733972..1735084 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" /label="desK CDS" gene 1733972..1735084 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /label="desK gene" CDS 1735103..1735702 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" /label="desR CDS" gene 1735103..1735702 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /label="desR gene" downshifts 1735640 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1735684 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1735724..1736222) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(1735760) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1736194..1736203 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1736206..1736224) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1736215..1736409 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 1736215 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1736216..1736235 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1736222) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1736241..1736246) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1736297..1737160) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" /label="walL CDS" gene complement(1736297..1737160) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /label="walL gene" downshifts complement(1736310) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 1736366 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1736398) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" S_feature 1736411..1737178 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 1737156..1737160 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1737169..1737183 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1737180 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1737199..1737218) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1737212) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1737214..1737407) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(1737230..1737236) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1737408..1739183) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" /label="recQ CDS" gene complement(1737408..1739183) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /label="recQ gene" S_feature complement(1739184..1739314) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(1739307..1739509) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" /label="ssrSA RNA" gene complement(1739307..1739509) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /label="ssrSA gene" downshifts complement(1739359) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1739507..1739526) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(1739525) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="upshifts" S_feature complement(1739527..1739719) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(1739539..1739546) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(1739748..1740374) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" /label="azoJ CDS" gene complement(1739748..1740374) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /label="azoJ gene" downshifts complement(1739764) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1740408..1740427) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(1740421) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="upshifts" promotor_-35 complement(1740441..1740448) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(1740525..1741016) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" /label="yocK CDS" gene complement(1740525..1741016) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /label="yocK gene" downshifts complement(1740534) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1741028..1741046) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(1741040) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="upshifts" promotor_-35 complement(1741060..1741066) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(1741091..1741423) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" /label="yocL CDS" gene complement(1741091..1741423) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /label="yocL gene" S_feature complement(1741424..1741714) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 1741439..1741444 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 1741459..1741477 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 1741461 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="upshifts" CDS 1741501..1741728 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" /label="yoyB CDS" gene 1741501..1741728 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /label="yoyB gene" CDS complement(1741715..1742191) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" /label="yocM CDS" gene complement(1741715..1742191) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /label="yocM gene" S_feature 1741729..1742236 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(1742192..1742294) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 1742209..1742214 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1742229..1742247 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1742238 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="upshifts" CDS 1742258..1742521 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" /label="yozN CDS" gene 1742258..1742521 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /label="yozN gene" promotor_-10 complement(1742274..1742293) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1742294) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1742296..1742821) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(1742307..1742311) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1742526..1742759 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" /label="yocN CDS" gene 1742526..1742759 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /label="yocN gene" downshifts 1742746 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1742845..1743189) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" /label="yozO CDS" gene complement(1742845..1743189) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /label="yozO gene" downshifts complement(1742866) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" /label="downshifts" S_feature complement(1743190..1743262) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(1743258..1743277) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1743262) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1743264..1743367) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(1743291..1743296) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1743354..1743369) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1743367) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1743382..1743391) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1743510) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1743546..1743749) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" /label="yozC CDS" gene complement(1743546..1743749) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /label="yozC gene" promotor_-10 complement(1743770..1743789) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1743788) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1743790..1743856) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(1743805..1743812) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1743822..1743829 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 1743841 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="upshifts" misc_feature complement(1743843..1743855) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1743843..1743862 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 1743846..1743978 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(1743867) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="upshifts" CDS 1743979..1745466 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" /label="dhaS CDS" gene 1743979..1745466 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /label="dhaS gene" promotor_-10 complement(1744422..1744439) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1744428) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1744452..1744460) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1745452 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1745514..1745519 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1745535..1745553 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1745540 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="upshifts" CDS 1745567..1747465 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" /label="sqhC CDS" gene 1745567..1747465 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /label="sqhC gene" promotor_-10 complement(1746510..1746529) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1746518) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1746543..1746552) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1747455..1748300 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" /label="sodF CDS" gene 1747455..1748300 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /label="sodF gene" S_feature 1748301..1749807 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(1748333..1749670) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" /label="yocR CDS" gene complement(1748333..1749670) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /label="yocR gene" downshifts complement(1748344) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1749698..1749717) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1749713) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1749715..1750873) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(1749732..1749739) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1749791..1749794 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1749809..1749828 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1749809 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="upshifts" CDS 1749889..1750854 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" /label="yocS CDS" gene 1749889..1750854 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /label="yocS gene" downshifts 1750842 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1750904..1752157) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" /label="odhB CDS" gene complement(1750904..1752157) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /label="odhB gene" downshifts complement(1750918) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" CDS complement(1752173..1755007) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" /label="odhA CDS" gene complement(1752173..1755007) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /label="odhA gene" promotor_-10 complement(1755102..1755121) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1755117) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1755119..1755235) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(1755136..1755143) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1755236..1757152) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" /label="yojO CDS" gene complement(1755236..1757152) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /label="yojO gene" CDS complement(1757163..1758077) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" /label="yojN CDS" gene complement(1757163..1758077) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /label="yojN gene" promotor_-10 complement(1758081..1758100) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(1758096) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="upshifts" promotor_-35 complement(1758117..1758121) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(1758141..1758731) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" /label="sodC CDS" gene complement(1758141..1758731) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /label="sodC gene" CDS complement(1758824..1760068) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" /label="cwlS CDS" gene complement(1758824..1760068) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /label="cwlS gene" downshifts complement(1758826) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1760131..1760149) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1760144) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1760146..1760366) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(1760162..1760169) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1760352..1760370) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1760366) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1760382..1760390) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1760450..1761667) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" /label="yojK CDS" gene complement(1760450..1761667) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /label="yojK gene" downshifts complement(1760476) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1761700..1761719) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1761708) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1761733..1761740) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1761903..1762526) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" /label="cdaS CDS" gene complement(1761903..1762526) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /label="cdaS gene" S_feature complement(1762527..1762677) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 1762553..1762559 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1762565 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1762573..1762584 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1762591..1762599 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1762607..1762707 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 1762611..1762629 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1762622 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1762660..1762678) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1762667..1762752 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 1762667 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1762677) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1762694..1762700) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1762728..1762735 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1762748..1762767 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1762754 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="upshifts" CDS 1762792..1764150 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" /label="mdtK CDS" gene 1762792..1764150 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /label="mdtK gene" promotor_-10 complement(1763134..1763145) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1763139) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1763159..1763165) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1764166..1765014 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" /label="rsbRC CDS" gene 1764166..1765014 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /label="rsbRC gene" promotor_-10 complement(1764430..1764449) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1764437) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1764463..1764471) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1764977 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1765009) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1765040..1765705) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" /label="bshBB CDS" gene complement(1765040..1765705) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /label="bshBB gene" downshifts complement(1765054) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1765724..1766074) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" /label="yojF CDS" gene complement(1765724..1766074) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /label="yojF gene" CDS complement(1766071..1766349) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" /label="yoyC CDS" gene complement(1766071..1766349) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /label="yoyC gene" promotor_-10 complement(1766376..1766395) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1766392) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1766410..1766416) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1766425..1767321) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" /label="yojE CDS" gene complement(1766425..1767321) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /label="yojE gene" promotor_-35 1767163..1767172 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1767183 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1767186..1767205 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1767201..1767419 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(1767345..1767364) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1767365) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1767376..1767383) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1767420..1767893 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" /label="gerT CDS" gene 1767420..1767893 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /label="gerT gene" downshifts 1767890 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1767928..1768164) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" /label="yojB CDS" gene complement(1767928..1768164) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /label="yojB gene" downshifts complement(1767936) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1768187..1768206) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1768202) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1768220..1768229) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1768249..1769583) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" /label="yojA CDS" gene complement(1768249..1769583) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /label="yojA gene" S_feature complement(1769584..1769719) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(1769716..1769735) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1769726) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1769750..1769757) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1769815..1769822 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1769837..1769856 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1769840 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1769841..1769947 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 1769948..1770337 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" /label="yodA CDS" gene 1769948..1770337 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /label="yodA gene" downshifts 1770347 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1770744..1771082) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" /label="arxR CDS" gene complement(1770744..1771082) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /label="arxR gene" promotor_-35 1771105..1771112 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1771126..1771145 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1771135 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="upshifts" S_feature 1771139..1771211 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(1771170..1771189) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1771173) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1771201..1771207) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1771212..1771820 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" /label="noxC CDS" gene 1771212..1771820 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /label="noxC gene" downshifts 1771810 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1771863..1772465) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" /label="yodD CDS" gene complement(1771863..1772465) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /label="yodD gene" CDS complement(1772481..1773392) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" /label="yodE CDS" gene complement(1772481..1773392) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /label="yodE gene" promotor_-10 complement(1773421..1773440) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1773437) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1773456..1773461) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1773513..1773516 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1773531..1773550 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1773533 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="upshifts" CDS 1773576..1773776 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" /label="yoyD CDS" gene 1773576..1773776 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /label="yoyD gene" CDS 1773776..1775266 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" /label="yodF CDS" gene 1773776..1775266 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /label="yodF gene" promotor_-10 complement(1774511..1774522) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1774515) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1774536..1774542) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1775254 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1775301..1776701) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" /label="ctpA CDS" gene complement(1775301..1776701) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /label="ctpA gene" downshifts complement(1775325) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-35 1776472..1776481 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1776493..1776508 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1776507 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1776721..1776740) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1776741) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1776754..1776761) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1776800..1776809 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1776815 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1776822..1776841 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1776854..1777555 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" /label="yodH CDS" gene 1776854..1777555 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /label="yodH gene" promotor_-35 1777580..1777588 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1777602..1777621 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1777607 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="upshifts" CDS 1777643..1777894 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" /label="yodI CDS" gene 1777643..1777894 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /label="yodI gene" downshifts 1777915 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1777965..1778786) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" /label="ldcB CDS" gene complement(1777965..1778786) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /label="ldcB gene" downshifts complement(1777991) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1778787..1778868) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(1778869..1779570) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" /label="deoD CDS" gene complement(1778869..1779570) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /label="deoD gene" S_feature complement(1779571..1779660) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(1779645..1779664) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1779660) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1779680..1779684) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1779718..1779724 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1779739..1779750 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1779756 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="upshifts" CDS 1779772..1779897 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" /label="yoyE CDS" gene 1779772..1779897 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /label="yoyE gene" downshifts 1779895 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1779937..1780251) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" /label="yodL CDS" gene complement(1779937..1780251) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /label="yodL gene" downshifts complement(1779949) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1780272..1780290) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1780279) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1780301..1780309) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1780312..1780923) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" /label="pgpB CDS" gene complement(1780312..1780923) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /label="pgpB gene" CDS complement(1781001..1781177) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" /label="yozD CDS" gene complement(1781001..1781177) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /label="yozD gene" downshifts complement(1781005) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1781016) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1781020..1781039) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1781055..1781058) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1781191..1781209) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(1781212) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="upshifts" S_feature complement(1781214..1781435) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(1781225..1781230) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 1781235..1781240 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1781255..1781273 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1781257 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="upshifts" CDS 1781296..1781439 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" /label="yoyF CDS" gene 1781296..1781439 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /label="yoyF gene" CDS complement(1781436..1782116) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" /label="yodN CDS" gene complement(1781436..1782116) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /label="yodN gene" S_feature 1781440..1782451 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(1782143..1782162) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1782149) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1782176..1782185) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1782267..1782491) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" /label="yozE CDS" gene complement(1782267..1782491) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /label="yozE gene" downshifts complement(1782281) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1782532..1782551) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1782544) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1782578..1782856) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" /label="yokU CDS" gene complement(1782578..1782856) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /label="yokU gene" CDS complement(1782853..1784268) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" /label="kamA CDS" gene complement(1782853..1784268) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /label="kamA gene" promotor_-35 1783524..1783527 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1783543..1783562 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1783548 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1784297..1785124) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " /label="kamB CDS" gene complement(1784297..1785124) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /label="kamB gene" CDS complement(1785102..1786412) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" /label="yodQ CDS" gene complement(1785102..1786412) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /label="yodQ gene" CDS complement(1786421..1787074) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " /label="yodR CDS" gene complement(1786421..1787074) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /label="yodR gene" CDS complement(1787059..1787748) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" /label="yodS CDS" gene complement(1787059..1787748) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /label="yodS gene" CDS complement(1787755..1789089) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" /label="yodT CDS" gene complement(1787755..1789089) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /label="yodT gene" CDS complement(1789070..1789225) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" /label="conserved hypothetical protein CDS" gene complement(1789070..1789225) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /label="gene" promotor_-10 complement(1789108..1789126) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1789124) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1789142..1789147) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1789219..1789452) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" /label="yoyG CDS" gene complement(1789219..1789452) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /label="yoyG gene" downshifts complement(1789226) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 1789328..1789332 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1789341..1789355 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1789356 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1789357..1789376) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1789366) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1789391..1789400) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1789412..1790191) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" /label="cgeE CDS" gene complement(1789412..1790191) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /label="cgeE gene" CDS complement(1790220..1791500) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" /label="cgeD CDS" gene complement(1790220..1791500) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /label="cgeD gene" promotor_-10 complement(1790868..1790886) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1790884) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1790900..1790907) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1791468..1791486) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1791478) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1791502..1791507) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1791565..1791870) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " /label="cgeC CDS" gene complement(1791565..1791870) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /label="cgeC gene" downshifts complement(1791698) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1791894..1791913) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(1791909) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="upshifts" promotor_-35 complement(1791927..1791936) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 1792006..1792015 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1792029..1792048 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1792029 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1792050) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1792052..1792066) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1792075..1792079) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1792075..1792476 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" /label="cgeA CDS" gene 1792075..1792476 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /label="cgeA gene" CDS 1792483..1793436 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" /label="cgeB CDS" gene 1792483..1793436 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /label="cgeB gene" downshifts 1793426 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1793507..1794655) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" /label="phyC CDS" gene complement(1793507..1794655) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /label="phyC gene" downshifts complement(1793524) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" promotor_-35 1794668..1794672 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1794681..1794700) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1794688..1794707 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1794690) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 1794698 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1794959..1794967 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1794981..1795000 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1794984 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="upshifts" CDS 1795025..1796050 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 1795025..1796050 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 1795428 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 <1795430..1795434 /Source="Nicolas_upshift_promotors" /id="U1702" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1418 /SigmaFactorBS="tttcatttttgacctcacagccactaATAGTTTCCActaaga aaagtagTAAGTATCTTAAAAAACAGAtaaagctgtatctcctgtgaacacaatgggt g" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" SCAR 1795444..1795445 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 1796042 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1796094..1796525) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" /label="msrB CDS" gene complement(1796094..1796525) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /label="msrB gene" downshifts complement(1796099) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1796526..1797059) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" /label="msrA CDS" gene complement(1796526..1797059) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /label="msrA gene" promotor_-35 1797063..1797069 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1797080..1797190 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 1797080 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1797082..1797101 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1797087..1797106) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1797107) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1797122..1797123) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1797191..1797616 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" /label="ypoP CDS" gene 1797191..1797616 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /label="ypoP gene" downshifts 1797604 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 1797649..1798880 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(1797666..1799003) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" /label="dinF CDS" gene complement(1797666..1799003) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /label="dinF gene" CDS complement(1799075..1799269) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" /label="ypmT CDS" gene complement(1799075..1799269) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /label="ypmT gene" downshifts complement(1799088) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1799282..1799845) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" /label="ypmS CDS" gene complement(1799282..1799845) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /label="ypmS gene" CDS complement(1799855..1800622) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" /label="ypmR CDS" gene complement(1799855..1800622) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /label="ypmR gene" promotor_-10 complement(1800646..1800665) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1800663) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1800676..1800683) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1800700..1801281) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" /label="scuA CDS" gene complement(1800700..1801281) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /label="scuA gene" S_feature complement(1801282..1801397) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(1801429..1801680) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" /label="ypmP CDS" gene complement(1801429..1801680) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /label="ypmP gene" downshifts complement(1801442) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1801703..1801722) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1801717) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1801766..1803034) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" /label="ilvA CDS" gene complement(1801766..1803034) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /label="ilvA gene" promotor_-10 complement(1803068..1803087) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1803087) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1803099..1803106) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1803241..1803260 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1803244 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="upshifts" CDS 1803283..1804278 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" /label="silP CDS" gene 1803283..1804278 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /label="silP gene" CDS 1804299..1804940 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" /label="yplQ CDS" gene 1804299..1804940 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /label="yplQ gene" S_feature 1804941..1806042 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(1804979..1805599) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" /label="ypkP CDS" gene complement(1804979..1805599) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /label="ypkP gene" downshifts complement(1805005) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1805600..1806106) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" /label="dfrA CDS" gene complement(1805600..1806106) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /label="dfrA gene" CDS complement(1806103..1806897) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" /label="thyB CDS" gene complement(1806103..1806897) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /label="thyB gene" CDS complement(1806981..1807514) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" /label="ypjQ CDS" gene complement(1806981..1807514) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /label="ypjQ gene" downshifts complement(1806986) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" /label="downshifts" promotor_-35 1807444..1807449 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1807460..1808406 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 1807462 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1807466..1807484 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1807532..1808143) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" /label="ypjP CDS" gene complement(1807532..1808143) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /label="ypjP gene" promotor_-10 complement(1808175..1808194) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1808194) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1808207..1808212) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1808363 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" /label="downshifts" CDS complement(1808403..1809176) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" /label="rsmJ CDS" gene complement(1808403..1809176) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /label="rsmJ gene" downshifts complement(1808438) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(1809218..1809652) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" /label="brxA CDS" gene complement(1809218..1809652) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /label="brxA gene" downshifts complement(1809230) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1809681..1809700) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(1809692) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="upshifts" S_feature complement(1809694..1809758) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(1809714..1809721) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(1809737) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1809759..1811435) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" /label="ilvD CDS" gene complement(1809759..1811435) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /label="ilvD gene" S_feature complement(1811436..1811626) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(1811615..1811634) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1811626) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1811649..1811652) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1811724..1812857) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" /label="ypgR CDS" gene complement(1811724..1812857) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /label="ypgR gene" downshifts complement(1811740) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature complement(1812879..1812898) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1812882) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1812917..1813534) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" /label="hdhQ CDS" gene complement(1812917..1813534) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /label="hdhQ gene" CDS complement(1813550..1814032) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" /label="bsaA CDS" gene complement(1813550..1814032) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /label="bsaA gene" S_feature complement(1814033..1814180) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(1814171..1814189) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(1814181) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="upshifts" promotor_-35 complement(1814200..1814208) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 1814234..1814243 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1814256..1814271 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 1814258..1814344 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 1814258 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" promotor_-35 1814307..1814314 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1814329..1814348 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 1814346 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" CDS 1814375..1815280 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" /label="metAA CDS" gene 1814375..1815280 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /label="metAA gene" misc_feature 1815315..1815334 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1815329 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" S_feature 1815330..1815510 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 1815511..1816659 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" /label="ugtP CDS" gene 1815511..1816659 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /label="ugtP gene" S_feature complement(1815680..1816709) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 1816655 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1816691..1816710) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1816709) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1816725..1816733) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1816740..1816886 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" /label="hypothetical protein CDS" gene 1816740..1816886 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /label="gene" promotor_-35 1816779..1816786 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1816800..1816819 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1816811..1816901 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 1816811 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1816902..1817102 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" /label="cspD CDS" gene 1816902..1817102 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /label="cspD gene" downshifts 1817117 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS complement(1817154..1817336) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" /label="degR CDS" gene complement(1817154..1817336) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /label="degR gene" S_feature 1817162..1817467 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(1817171) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1817397..1817415) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1817429..1817435) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1817433) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1817443..1817449 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1817464..1817475 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1817469 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1817492..1817761 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" /label="ypzA CDS" gene 1817492..1817761 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /label="ypzA gene" downshifts 1817616 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" /label="downshifts" downshifts 1817744 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(1817789..1817971) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" /label="ypeQ CDS" gene complement(1817789..1817971) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /label="ypeQ gene" downshifts complement(1817809) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1817964..1818644) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" /label="ypeP CDS" gene complement(1817964..1818644) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /label="ypeP gene" S_feature complement(1818645..1818782) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 1818661..1818666 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1818679..1818698 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1818684 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1818727..1819416 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" /label="queP CDS" gene 1818727..1819416 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /label="queP gene" promotor_-35 complement(1818780..1818796) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1818783) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1818784..1819173) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(1819154..1819173) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1819171) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1819185..1819193) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1819416..1819814 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" /label="ypdQ CDS" gene 1819416..1819814 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /label="ypdQ gene" promotor_-35 1819807..1819813 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1819828..1819839 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1819839 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1819856..1819984 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" /label="sspL CDS" gene 1819856..1819984 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /label="sspL gene" S_feature 1819985..1820965 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(1819992..1820882) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" /label="exnP CDS" gene complement(1819992..1820882) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /label="exnP gene" downshifts complement(1820029) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1820904..1820923) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1820911) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1820935..1820941) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1820939 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(1820983..1821129) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" /label="ypzF CDS" gene complement(1820983..1821129) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /label="ypzF gene" downshifts complement(1820999) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1821153) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1821154..1821165) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1821180..1821186) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1821204..1821461) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" /label="ypbS CDS" gene complement(1821204..1821461) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /label="ypbS gene" promotor_-10 complement(1821481..1821500) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1821496) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1821512..1821519) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1821526..1825107) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" /label="dynA CDS" gene complement(1821526..1825107) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /label="dynA gene" S_feature complement(1825108..1825179) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(1825169..1825188) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1825179) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="upshifts" S_feature complement(1825224..1825421) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(1825267) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1825283..1825372) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" /label="fbpC CDS" gene complement(1825283..1825372) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /label="fbpC gene" promotor_-10 complement(1825400..1825419) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1825421) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1825434..1825441) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1825443..1825949) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" /label="bpsB CDS" gene complement(1825443..1825949) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /label="bpsB gene" CDS complement(1825953..1827050) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" /label="bpsA CDS" gene complement(1825953..1827050) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /label="bpsA gene" promotor_-10 complement(1827068..1827079) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1827071) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1827094..1827100) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1827124..1828440) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" /label="pbuX CDS" gene complement(1827124..1828440) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /label="pbuX gene" downshifts complement(1827137) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1828437..1829021) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" /label="xpt CDS" gene complement(1828437..1829021) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /label="xpt gene" misc_RNA complement(1829110..1829210) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswA RNA" gene complement(1829110..1829210) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /label="gswA gene" downshifts complement(1829117) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" S_feature complement(1829211..1829351) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(1829352..1830857) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" /label="ypwA CDS" gene complement(1829352..1830857) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /label="ypwA gene" promotor_no_box complement(1830793..1830893) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1830833) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" downshifts 1830845 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1830883..1830902) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1830899) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1830916..1830923) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1830969..1831961) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" /label="kdgT CDS" gene complement(1830969..1831961) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /label="kdgT gene" downshifts complement(1830987) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1832006..1832596) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" /label="kdgA CDS" gene complement(1832006..1832596) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /label="kdgA gene" CDS complement(1832598..1833572) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" /label="kdgK CDS" gene complement(1832598..1833572) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /label="kdgK gene" CDS complement(1833610..1834629) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" /label="kdgR CDS" gene complement(1833610..1834629) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /label="kdgR gene" promotor_-10 complement(1834677..1834696) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1834687) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1834708..1834715) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1834750..1834757 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1834771..1834850 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 1834771 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1834772..1834791 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1834851..1835678 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " /label="kduI CDS" gene 1834851..1835678 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /label="kduI gene" CDS 1835680..1836444 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" /label="kduD CDS" gene 1835680..1836444 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /label="kduD gene" downshifts 1836433 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1836475) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(1836485..1838410) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" /label="ypvA CDS" gene complement(1836485..1838410) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /label="ypvA gene" promotor_-10 complement(1838441..1838460) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1838445) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1838447..1838511) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(1838475..1838479) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1838512..1838703) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" /label="yptA CDS" gene complement(1838512..1838703) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /label="yptA gene" promotor_-10 complement(1838722..1838740) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1838731) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1838733..1839038) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(1838756..1838761) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1838770..1838776 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1838791..1838802 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1838800 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="upshifts" CDS 1838867..1839019 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" /label="ypzG CDS" gene 1838867..1839019 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /label="ypzG gene" downshifts 1839029 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1839072..1840229) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" /label="rlmKB CDS" gene complement(1839072..1840229) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /label="rlmKB gene" downshifts complement(1839083) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1840317..1840717) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rnpB RNA" gene complement(1840317..1840717) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /label="rnpB gene" downshifts complement(1840327) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1840714..1840733) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1840732) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1840748..1840754) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1840776..1841072) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" /label="gpsB CDS" gene complement(1840776..1841072) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /label="gpsB gene" promotor_-10 complement(1841097..1841116) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1841107) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1841130..1841137) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1841150..1841779) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" /label="ypsA CDS" gene complement(1841150..1841779) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /label="ypsA gene" downshifts complement(1841745) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1841781..1842008) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" /label="cotD CDS" gene complement(1841781..1842008) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /label="cotD gene" promotor_-10 complement(1842036..1842055) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(1842051) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="upshifts" S_feature complement(1842053..1842207) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(1842069..1842077) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(1842092..1842220) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" /label="conserved protein of unknown function CDS" gene complement(1842092..1842220) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /label="gene" upshifts complement(1842207) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" S_feature complement(1842209..1842320) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(1842210..1842229) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(1842245..1842249) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1842321..1843562) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" /label="yprB CDS" gene complement(1842321..1843562) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /label="yprB gene" promotor_-10 complement(1843276..1843294) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(1843285) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="upshifts" promotor_-35 complement(1843309..1843316) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(1843578..1845827) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" /label="yprA CDS" gene complement(1843578..1845827) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /label="yprA gene" promotor_-10 complement(1845843..1845862) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1845859) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1845876..1845882) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1845930..1846436) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" /label="ypqE CDS" gene complement(1845930..1846436) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /label="ypqE gene" downshifts complement(1845953) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1846480..1846499) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1846497) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1846513..1846520) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 1846518..1846527 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1846541..1846560 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1846553 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="upshifts" CDS 1846574..1846993 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" /label="ypqA CDS" gene 1846574..1846993 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /label="ypqA gene" S_feature 1846994..1847144 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(1847014..1847391) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" /label="yppG CDS" gene complement(1847014..1847391) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /label="yppG gene" downshifts complement(1847047) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature 1847389..1847534 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(1847421..1847439) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1847440) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1847453..1847462) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1847535..1847554 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1847536 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1847579..1847767 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" /label="yppF CDS" gene 1847579..1847767 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /label="yppF gene" downshifts 1847783 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" CDS complement(1847806..1848177) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" /label="yppE CDS" gene complement(1847806..1848177) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /label="yppE gene" downshifts complement(1847839) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1848189..1848208) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1848202) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1848221..1848226) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1848223..1848468) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" /label="yppD CDS" gene complement(1848223..1848468) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /label="yppD gene" promotor_-10 complement(1848494..1848512) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1848499) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1848524..1848532) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1848618..1848624 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1848639..1848650 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1848646 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="upshifts" CDS 1848667..1848771 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" /label="sspM CDS" gene 1848667..1848771 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /label="sspM gene" downshifts 1848753 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1848796..1849758) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" /label="yppC CDS" gene complement(1848796..1849758) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /label="yppC gene" promotor_-35 1848926..1848935 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1848947..1848962 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1848947 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1848951..1849286 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 1849257..1849261 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1849277..1849296 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1849288..1849798 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 1849288 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1849759..1850215) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 1849799..1850419 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" /label="recU CDS" gene 1849799..1850419 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /label="recU gene" promotor_-10 complement(1850204..1850215) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1850215) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1850230..1850236) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1850441..1853185 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" /label="ponA CDS" gene 1850441..1853185 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /label="ponA gene" downshifts complement(1852855) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" /label="downshifts" downshifts 1853171 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1853261..1853755) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" /label="ypoC CDS" gene complement(1853261..1853755) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /label="ypoC gene" downshifts complement(1853274) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1853752..1854411) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" /label="nth CDS" gene complement(1853752..1854411) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /label="nth gene" CDS complement(1854430..1855128) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" /label="dnaD CDS" gene complement(1854430..1855128) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /label="dnaD gene" S_feature complement(1855129..1855220) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(1855221..1856513) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" /label="asnS CDS" gene complement(1855221..1856513) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /label="asnS gene" S_feature complement(1856514..1856575) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(1856575..1856594) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1856575) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1856609..1856616) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1856657..1857838) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" /label="aspB CDS" gene complement(1856657..1857838) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /label="aspB gene" downshifts complement(1856661) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1857861..1858346) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" /label="tseB CDS" gene complement(1857861..1858346) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /label="tseB gene" promotor_-10 complement(1858294..1858313) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1858311) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1858326..1858333) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1858355..1858525) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" /label="ypmA CDS" gene complement(1858355..1858525) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /label="ypmA gene" S_feature complement(1858526..1858597) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 1858559..1858565 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1858580..1858599) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1858580..1858591 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1858587..1858661 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 1858587 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1858597) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1858599..1858667) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(1858615..1858621) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1858631 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1858668..1861463) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" /label="dinG CDS" gene complement(1858668..1861463) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /label="dinG gene" promotor_-35 1859136..1859140 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1859137 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1859142..1859146 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1859793..1859808) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1859807) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1859821..1859830) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(1861464..1861588) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(1861589..1861972) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" /label="panD CDS" gene complement(1861589..1861972) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /label="panD gene" CDS complement(1861974..1862834) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" /label="panC CDS" gene complement(1861974..1862834) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /label="panC gene" CDS complement(1862836..1863669) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" /label="panB CDS" gene complement(1862836..1863669) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /label="panB gene" S_feature complement(1863670..1863877) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(1863872..1863891) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1863877) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1863908..1863912) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1863915..1864892) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" /label="birA CDS" gene complement(1863915..1864892) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /label="birA gene" CDS complement(1864877..1866070) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" /label="cca CDS" gene complement(1864877..1866070) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /label="cca gene" CDS complement(1866075..1867208) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" /label="bshA CDS" gene complement(1866075..1867208) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /label="bshA gene" CDS complement(1867205..1867915) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" /label="bshBA CDS" gene complement(1867205..1867915) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /label="bshBA gene" CDS complement(1867908..1868321) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" /label="mgsA CDS" gene complement(1867908..1868321) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /label="mgsA gene" CDS complement(1868337..1869140) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" /label="dapB CDS" gene complement(1868337..1869140) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /label="dapB gene" CDS complement(1869152..1869487) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" /label="ypjD CDS" gene complement(1869152..1869487) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /label="ypjD gene" promotor_-10 complement(1869507..1869526) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1869517) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1869540..1869547) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 1869556..1869563 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1869572..1869591) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1869577..1869596 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1869583 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1869591) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" CDS 1869627..1870499 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" /label="ypjC CDS" gene 1869627..1870499 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /label="ypjC gene" CDS complement(1870541..1871335) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" /label="ypjB CDS" gene complement(1870541..1871335) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /label="ypjB gene" downshifts complement(1870566) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" /label="downshifts" S_feature complement(1871336..1871403) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(1871404..1871961) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" /label="ypjA CDS" gene complement(1871404..1871961) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /label="ypjA gene" S_feature complement(1871962..1872041) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(1872086) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1872108..1872875) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" /label="qcrC CDS" gene complement(1872108..1872875) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /label="qcrC gene" CDS complement(1872910..1873584) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" /label="qcrB CDS" gene complement(1872910..1873584) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /label="qcrB gene" CDS complement(1873586..1874089) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" /label="qcrA CDS" gene complement(1873586..1874089) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /label="qcrA gene" downshifts 1874098 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1874153..1874172) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1874153) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1874187..1874194) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1874232..1874678) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" /label="ypiF CDS" gene complement(1874232..1874678) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /label="ypiF gene" downshifts 1874681 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" /label="downshifts" CDS complement(1874733..1875272) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" /label="ypiB CDS" gene complement(1874733..1875272) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /label="ypiB gene" downshifts complement(1874746) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1875305..1875323) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1875316) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="upshifts" promotor_-35 complement(1875335..1875343) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(1875344..1876615) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" /label="ypiA CDS" gene complement(1875344..1876615) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /label="ypiA gene" S_feature complement(1876616..1876683) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(1876680..1876699) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1876683) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1876713..1876720) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1876750..1876769) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1876756) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="upshifts" S_feature complement(1876758..1876902) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(1876780..1876787) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(1876884..1876902) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1876902) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1876918..1876923) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1876951..1878237) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" /label="aroA CDS" gene complement(1876951..1878237) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /label="aroA gene" downshifts complement(1876974) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1878248..1879363) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" /label="tyrA CDS" gene complement(1878248..1879363) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /label="tyrA gene" CDS complement(1879412..1880494) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" /label="hisC CDS" gene complement(1879412..1880494) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /label="hisC gene" CDS complement(1880505..1881308) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" /label="trpA CDS" gene complement(1880505..1881308) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /label="trpA gene" promotor_-10 complement(1880993..1881012) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1881010) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1881024..1881031) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1881301..1882503) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" /label="trpB CDS" gene complement(1881301..1882503) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /label="trpB gene" CDS complement(1882484..1883131) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" /label="trpF CDS" gene complement(1882484..1883131) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /label="trpF gene" downshifts complement(1882578) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" /label="downshifts" misc_feature complement(1882754..1882757) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1882754) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" downshifts complement(1882974) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" /label="downshifts" misc_feature 1883136..1883888 /created_by="AR/SM" /id="IIG_Bs01" /note="due to the curing of the trpC2 locus (auxotrophy) of the Delta6 strain by transformation with chromosomal DNA from donor Bsu 3NA multiple snp`s were transferred to the oroginal trpC locus" /modified_by="User" /label="IIG_Bs01" /note="Geneious type: MiniBacillus__exchange" CDS complement(1883136..1883888) /locus_tag="PG10_trpC_var_BEP06_07765" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_007409461.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /protein_id="ANY35339.1" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASLNRFIGLIA EVKKASPSKGLIKENFVPVRIAKDYETAKADALSVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKEMDVLVEVHDA TTLEQILKVFTPDILGINNRNLKTFETSIMQTEQIASLAPKESLLVSESGIGSLEHLT FVKEHGARAVLIGESLMRQTSQRKAIHALFRE*" /label="PG10_trpC_var_BEP06_07765" gene complement(1883136..1883888) /locus_tag="PG10_trpC_var_BEP06_07765" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /label="PG10_trpC_var_BEP06_07765" misc_feature complement(1883169..1883171) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1883172 /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" Polymorphism join(1883278,1883281) /Source="geneious" /ID="SNP_BsPG10_2374282_2374283" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change /CDS_Position=606 /Change="AG -> GT" /Codon_Change="TCC,TTG -> TCA,CTG" /Coverage="129 -> 130" /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="AG" /Variant_Nucleotides="GT" /Variant_P_Value="2e-203" /Variant_Raw_Frequency="128 -> 129" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883292,1883294) /Source="geneious" /ID="SNP_BsPG10_2374296_2374296" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> A" /CDS_Position=593 /Change="A -> G" /Codon_Change="GTT -> GCT" /Coverage=119 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.2e-179" /Variant_Raw_Frequency=119 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883294,1883296) /Source="geneious" /ID="SNP_BsPG10_2374298_2374298" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=591 /Change="G -> A" /Codon_Change="CTC -> CTT" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="9.9e-148" /Variant_Raw_Frequency=116 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883319,1883321) /Source="geneious" /ID="SNP_BsPG10_2374323_2374323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="K -> M" /CDS_Position=566 /Change="T -> A" /Codon_Change="AAG -> ATG" /Coverage=81 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="A" /Variant_P_Value="6.3e-98" /Variant_Raw_Frequency=81 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883321,1883325) /Source="geneious" /ID="SNP_BsPG10_2374325_2374327" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="V -> I" /CDS_Position=562 /Change="TAC -> GAT" /Codon_Change="GTA -> ATC" /Coverage="79 -> 84" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="TAC" /Variant_Nucleotides="GAT" /Variant_P_Value="2.3e-77" /Variant_Raw_Frequency="74 -> 78" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883327,1883329) /Source="geneious" /ID="SNP_BsPG10_2374331_2374331" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=558 /Change="T -> G" /Codon_Change="ACA -> ACC" /Coverage=70 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="1e-63" /Variant_Raw_Frequency=70 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883336,1883338) /Source="geneious" /ID="SNP_BsPG10_2374340_2374340" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=549 /Change="C -> A" /Codon_Change="ACG -> ACT" /Coverage=59 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="A" /Variant_P_Value="1e-59" /Variant_Raw_Frequency=59 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883351,1883353) /Source="geneious" /ID="SNP_BsPG10_2374355_2374355" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=534 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=66 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="6e-64" /Variant_Raw_Frequency=65 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883354,1883356) /Source="geneious" /ID="SNP_BsPG10_2374358_2374358" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=531 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=63 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.3e-68" /Variant_Raw_Frequency=60 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883359,1883361) /Source="geneious" /ID="SNP_BsPG10_2374363_2374363" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> I" /CDS_Position=526 /Change="C -> T" /Codon_Change="GTA -> ATA" /Coverage=65 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="3.9e-82" /Variant_Raw_Frequency=64 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883369,1883371) /Source="geneious" /ID="SNP_BsPG10_2374373_2374373" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=516 /Change="G -> A" /Codon_Change="GAC -> GAT" /Coverage=79 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="7.7e-116" /Variant_Raw_Frequency=78 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883372,1883374) /Source="geneious" /ID="SNP_BsPG10_2374376_2374376" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=513 /Change="G -> A" /Codon_Change="CCC -> CCT" /Coverage=92 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="4e-141" /Variant_Raw_Frequency=90 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883375,1883377) /Source="geneious" /ID="SNP_BsPG10_2374379_2374379" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=510 /Change="T -> C" /Codon_Change="ACA -> ACG" /Coverage=97 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.3e-165" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883381,1883383) /Source="geneious" /ID="SNP_BsPG10_2374385_2374385" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=504 /Change="C -> T" /Codon_Change="GTG -> GTA" /Coverage=109 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="4.3e-193" /Variant_Raw_Frequency=108 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883407,1883409) /Source="geneious" /ID="SNP_BsPG10_2374411_2374411" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="S -> T" /CDS_Position=478 /Change="A -> T" /Codon_Change="TCA -> ACA" /Coverage=148 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value="2.9e-307" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883439,1883441) /Source="geneious" /ID="SNP_BsPG10_2374443_2374443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="G -> E" /CDS_Position=446 /Change="C -> T" /Codon_Change="GGG -> GAG" /Coverage=161 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=161 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883492,1883494) /Source="geneious" /ID="SNP_BsPG10_2374496_2374496" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=393 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=174 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883540,1883542) /Source="geneious" /ID="SNP_BsPG10_2374544_2374544" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=345 /Change="T -> C" /Codon_Change="GTA -> GTG" /Coverage=168 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=167 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883555,1883559) /Source="geneious" /ID="SNP_BsPG10_2374559_2374558" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=0 /Amino_Acid_Change="-> I" /CDS_Position=331 /Change="AAT" /Codon_Change="-> ATT" /Coverage=164 /locus_tag="BSU_22660" /Protein_Effect="Insertion" /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="AAT" /Variant_P_Value="3.90000001038273e-316" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883573,1883575) /Source="geneious" /ID="SNP_BsPG10_2374574_2374574" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=315 /Change="A -> G" /Codon_Change="CTT -> CTC" /Coverage=155 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883582,1883584) /Source="geneious" /ID="SNP_BsPG10_2374583_2374583" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=306 /Change="A -> T" /Codon_Change="ATT -> ATA" /Coverage=153 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=152 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883594,1883596) /Source="geneious" /ID="SNP_BsPG10_2374595_2374595" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=294 /Change="A -> G" /Codon_Change="CGT -> CGC" /Coverage=128 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="4e-295" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883659,1883661) /Source="geneious" /ID="SNP_BsPG10_2374660_2374660" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="I -> L" /CDS_Position=229 /Change="T -> G" /Codon_Change="ATT -> CTT" /Coverage=131 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="2.3e-302" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883669,1883671) /Source="geneious" /ID="SNP_BsPG10_2374670_2374670" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=219 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=126 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="1.6e-290" /Variant_Raw_Frequency=126 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883677,1883680) /Source="geneious" /ID="SNP_BsPG10_2374678_2374679" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="EA -> ET" /CDS_Position=210 /Change="CC -> TT" /Codon_Change="GAG,GCT -> GAA,ACT" /Coverage="124 -> 130" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="CC" /Variant_Nucleotides="TT" /Variant_P_Value="4.7e-253" /Variant_Raw_Frequency="119 -> 125" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883697,1883699) /Source="geneious" /ID="SNP_BsPG10_2374698_2374698" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="Q -> R" /CDS_Position=191 /Change="T -> C" /Codon_Change="CAG -> CGG" /Coverage=104 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="9e-228" /Variant_Raw_Frequency=101 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883713,1883715) /Source="geneious" /ID="SNP_BsPG10_2374714_2374714" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="D -> N" /CDS_Position=175 /Change="C -> T" /Codon_Change="GAT -> AAT" /Coverage=95 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency="1.1%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="2.8e-220" /Variant_Raw_Frequency=93 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883741,1883743) /Source="geneious" /ID="SNP_BsPG10_2374742_2374742" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=147 /Change="T -> C" /Codon_Change="GCA -> GCG" /Coverage=98 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.2e-260" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883756,1883758) /Source="geneious" /ID="SNP_BsPG10_2374757_2374757" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=132 /Change="G -> A" /Codon_Change="GCC -> GCT" /Coverage=197 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value /Variant_Raw_Frequency /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883781,1883783) /Source="geneious" /ID="SNP_BsPG10_2374782_2374782" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="P -> L" /CDS_Position=107 /Change="G -> A" /Codon_Change="CCG -> CTG" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value=0 /Variant_Raw_Frequency=118 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883798,1883800) /Source="geneious" /ID="SNP_BsPG10_2374799_2374799" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=90 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=133 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=131 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1883813,1883815) /Source="geneious" /ID="SNP_BsPG10_2374814_2374814" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=75 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=130 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=130 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" CDS complement(1883881..1884897) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /modified_by="User" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" /label="trpD CDS" gene complement(1883881..1884897) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /modified_by="User" /label="trpD gene" CDS complement(1884869..1886416) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" /label="trpE CDS" gene complement(1884869..1886416) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /label="trpE gene" S_feature complement(1886495..1886626) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(1886538) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1886617..1886636) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(1886626) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" CDS complement(1886632..1887015) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" /label="aroH CDS" gene complement(1886632..1887015) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /label="aroH gene" promotor_-35 complement(1886651..1886658) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(1887012..1888100) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" /label="aroB CDS" gene complement(1887012..1888100) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /label="aroB gene" promotor_-10 complement(1887141..1887156) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1887154) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1887169..1887177) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1888100..1889272) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" /label="aroF CDS" gene complement(1888100..1889272) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /label="aroF gene" promotor_-10 complement(1889307..1889326) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1889324) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1889339..1889346) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1889347..1890117) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" /label="cheR CDS" gene complement(1889347..1890117) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /label="cheR gene" promotor_-10 complement(1890143..1890162) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1890160) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1890174..1890180) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(1890192..1890353) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(1890235) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" CDS complement(1890354..1890803) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" /label="ndk CDS" gene complement(1890354..1890803) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /label="ndk gene" promotor_-10 complement(1890846..1890865) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1890853) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1890878..1890885) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1890919..1891965) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" /label="hepT CDS" gene complement(1890919..1891965) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /label="hepT gene" CDS complement(1891907..1892608) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" /label="menG CDS" gene complement(1891907..1892608) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /label="menG gene" CDS complement(1892615..1893370) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" /label="hepS CDS" gene complement(1892615..1893370) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /label="hepS gene" S_feature complement(1893371..1893456) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(1893445..1893464) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1893456) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1893475..1893482) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1893534..1893761) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" /label="mtrB CDS" gene complement(1893534..1893761) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /label="mtrB gene" downshifts complement(1893555) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" /label="downshifts" CDS complement(1893783..1894355) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" /label="folEA CDS" gene complement(1893783..1894355) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /label="folEA gene" promotor_-10 complement(1894384..1894403) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1894394) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" S_feature complement(1894396..1894479) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(1894416..1894422) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(1894524) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" /label="downshifts" CDS complement(1894543..1894821) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" /label="hbs CDS" gene complement(1894543..1894821) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /label="hbs gene" S_feature complement(1894822..1895047) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(1895029..1895048) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1895047) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1895065..1895070) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1895195..1896673) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" /label="spoIVA CDS" gene complement(1895195..1896673) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /label="spoIVA gene" downshifts complement(1895208) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1896674..1896835) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(1896822..1896840) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(1896847) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="upshifts" CDS complement(1896854..1897588) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" /label="yphF CDS" gene complement(1896854..1897588) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /label="yphF gene" promotor_-35 complement(1896855..1896860) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(1896880) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" /label="downshifts" CDS complement(1897610..1897813) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" /label="yphE CDS" gene complement(1897610..1897813) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /label="yphE gene" promotor_-10 complement(1897849..1897868) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1897870) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1897882..1897889) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1897935..1898134) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(1897978) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1898109..1898128) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1898134) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1898142..1898151) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1898151..1899188) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" /label="gpsA CDS" gene complement(1898151..1899188) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /label="gpsA gene" CDS complement(1899206..1900516) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" /label="der CDS" gene complement(1899206..1900516) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /label="der gene" S_feature complement(1900517..1900641) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(1900627..1900646) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1900641) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1900661..1900664) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1900670..1900864) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" /label="ypzH CDS" gene complement(1900670..1900864) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /label="ypzH gene" CDS complement(1900861..1901754) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" /label="yphB CDS" gene complement(1900861..1901754) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /label="yphB gene" CDS complement(1901751..1902350) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" /label="yphA CDS" gene complement(1901751..1902350) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /label="yphA gene" promotor_-35 1902223..1902229 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1902238..1902421 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 1902240 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1902243..1902254 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1902361..1902379) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1902380) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1902395..1902400) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1902428..1902559 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " /label="ypzI CDS" gene 1902428..1902559 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /label="ypzI gene" downshifts 1902547 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1902602..1903651) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" /label="fni CDS" gene complement(1902602..1903651) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /label="fni gene" downshifts complement(1902622) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1903526) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" /label="downshifts" CDS complement(1903664..1904812) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" /label="rpfA CDS" gene complement(1903664..1904812) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /label="rpfA gene" misc_feature 1903993..1903996 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1904020 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1904086 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1904790 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" /label="downshifts" S_feature complement(1904813..1904952) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(1904951..1904970) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1904952) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1904954..1905044) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(1904985..1904992) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1905045..1905719) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" /label="cmk CDS" gene complement(1905045..1905719) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /label="cmk gene" S_feature complement(1905720..1905797) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(1905798..1905974) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" /label="ypfB CDS" gene complement(1905798..1905974) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /label="ypfB gene" promotor_-10 complement(1905986..1906004) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1906003) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1906019..1906025) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1906019..1906672) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " /label="dgrA CDS" gene complement(1906019..1906672) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /label="dgrA gene" promotor_-10 complement(1906702..1906721) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1906715) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1906737..1906741) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1906765..1908117) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" /label="sleC CDS" gene complement(1906765..1908117) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /label="sleC gene" downshifts complement(1906780) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1908152..1909069) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" /label="sleB CDS" gene complement(1908152..1909069) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /label="sleB gene" downshifts complement(1908540) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" /label="downshifts" misc_feature complement(1908691..1908698) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1908694) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1909107..1909118) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1909116) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1909132..1909138) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1909208..1909864) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" /label="prsW CDS" gene complement(1909208..1909864) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /label="prsW gene" downshifts complement(1909222) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1909889..1909908) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1909904) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1909984..1910958) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" /label="ypdA CDS" gene complement(1909984..1910958) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /label="ypdA gene" downshifts complement(1909992) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-35 1910812..1910817 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1910833..1910851 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1910843..1911036 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 1910843 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="upshifts" downshifts 1910994 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1911067..1912350) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" /label="gudB CDS" gene complement(1911067..1912350) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /label="gudB gene" downshifts complement(1911070) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" /label="downshifts" promotor_-35 1911108..1911114 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1911126..1911130 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1911126 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1912393..1912412) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1912414) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1912427..1912434) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1912506..1913090) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" /label="mecB CDS" gene complement(1912506..1913090) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /label="mecB gene" downshifts complement(1912508) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" /label="downshifts" S_feature complement(1913091..1913172) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(1913165..1913184) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(1913172) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="upshifts" promotor_-35 complement(1913198..1913205) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(1913249..1914028) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" /label="ypbG CDS" gene complement(1913249..1914028) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /label="ypbG gene" promotor_-10 complement(1914054..1914069) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(1914065) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="upshifts" promotor_-35 complement(1914081..1914090) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(1914114..1914557) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" /label="ypbF CDS" gene complement(1914114..1914557) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /label="ypbF gene" downshifts complement(1914131) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1914620..1915342) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" /label="ypbE CDS" gene complement(1914620..1915342) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /label="ypbE gene" downshifts complement(1914901) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" CDS complement(1915293..1915862) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" /label="ypbD CDS" gene complement(1915293..1915862) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /label="ypbD gene" promotor_-10 complement(1915611..1915629) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1915627) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1915644..1915650) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1915881..1916627 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(1915922..1917412) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" /label="recS CDS" gene complement(1915922..1917412) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /label="recS gene" CDS complement(1917405..1918463) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" /label="gmmB CDS" gene complement(1917405..1918463) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /label="gmmB gene" promotor_-35 1917753..1917762 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1917773..1918563 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 1917773 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1917775..1917794 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1918504..1918523) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1918527) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1918535..1918542) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1918541..1918547 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 1918561..1918580 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 1918565..1918634 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 1918565 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="upshifts" promotor_-35 1918614..1918621 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1918636..1918728 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 1918636..1918655 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1918636 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="upshifts" CDS 1918729..1918977 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" /label="fer CDS" gene 1918729..1918977 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /label="fer gene" downshifts 1918961 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1919017..1919589) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" /label="fmnP CDS" gene complement(1919017..1919589) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /label="fmnP gene" downshifts complement(1919037) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1919581..1919888) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" /label="fswB RNA" gene complement(1919581..1919888) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /label="fswB gene" S_feature complement(1919590..1919694) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(1919887..1919906) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1919903) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1919920..1919926) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1920015..1920022 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1920033 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1920037..1920056 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1920086..1921663 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" /label="serA CDS" gene 1920086..1921663 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /label="serA gene" downshifts 1921645 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(1921706..1922473) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" /label="aroC CDS" gene complement(1921706..1922473) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /label="aroC gene" downshifts complement(1921721) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1921975..1922587 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(1922500..1922519) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1922513) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1922534..1922537) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1922547 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS complement(1922585..1923691) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" /label="rsiX CDS" gene complement(1922585..1923691) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /label="rsiX gene" downshifts complement(1922602) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" /label="downshifts" CDS complement(1923627..1924211) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" /label="sigX CDS" gene complement(1923627..1924211) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /label="sigX gene" promotor_-35 1924005..1924010 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1924021 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1924025..1924029 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1924162..1924167 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1924179 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1924183..1924201 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1924219 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1924260..1924279) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1924264..1924371 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(1924268) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1924292..1924299) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1924327 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(1924356..1924414) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(1924387) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1924415..1926184) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" /label="resE CDS" gene complement(1924415..1926184) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /label="resE gene" downshifts complement(1924471) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(1926181..1926903) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" /label="resD CDS" gene complement(1926181..1926903) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /label="resD gene" S_feature complement(1926904..1926983) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(1926984..1928159) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " /label="resC CDS" gene complement(1926984..1928159) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /label="resC gene" CDS complement(1928179..1929807) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" /label="resB CDS" gene complement(1928179..1929807) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /label="resB gene" CDS complement(1929804..1930343) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" /label="resA CDS" gene complement(1929804..1930343) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /label="resA gene" S_feature complement(1930344..1930437) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(1930438..1931172) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" /label="rluB CDS" gene complement(1930438..1931172) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /label="rluB gene" promotor_-10 complement(1931181..1931200) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1931204) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1931215..1931219) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1931264..1931800) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" /label="spmB CDS" gene complement(1931264..1931800) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /label="spmB gene" promotor_-10 complement(1931269..1931288) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1931273) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1931303..1931310) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1931805..1932395) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" /label="spmA CDS" gene complement(1931805..1932395) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /label="spmA gene" CDS complement(1932383..1933531) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" /label="dacB CDS" gene complement(1932383..1933531) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /label="dacB gene" promotor_-10 complement(1933553..1933571) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1933560) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1933586..1933591) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1933654..1934193) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" /label="ypuI CDS" gene complement(1933654..1934193) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /label="ypuI gene" downshifts complement(1933667) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1934202..1934219) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1934217) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1934234..1934239) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1934248..1934841) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" /label="spcB CDS" gene complement(1934248..1934841) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /label="spcB gene" CDS complement(1934831..1935586) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" /label="scpA CDS" gene complement(1934831..1935586) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /label="scpA gene" promotor_-35 1935430..1935439 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1935452..1935471 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1935461 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1935632..1935651) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1935647) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1935665..1935672) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1935812..1935819 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1935830..1935849 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1935835 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="upshifts" CDS 1935867..1936391 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" /label="ypuF CDS" gene 1935867..1936391 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /label="ypuF gene" CDS complement(1936405..1936779) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" /label="ypzK CDS" gene complement(1936405..1936779) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /label="ypzK gene" downshifts complement(1936421) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1936841..1936860) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1936853) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1936872..1936879) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1936892..1937356) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" /label="ribH CDS" gene complement(1936892..1937356) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /label="ribH gene" promotor_-35 1937227..1937231 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1937245..1937249 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1937248 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1937389..1938585) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" /label="ribBA CDS" gene complement(1937389..1938585) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /label="ribBA gene" CDS complement(1938600..1939247) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" /label="ribE CDS" gene complement(1938600..1939247) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /label="ribE gene" CDS complement(1939258..1940343) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" /label="ribD CDS" gene complement(1939258..1940343) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /label="ribD gene" S_feature complement(1940344..1940472) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(1940473..1940617) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" /label="fswA RNA" gene complement(1940473..1940617) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /label="fswA gene" promotor_-10 complement(1940634..1940653) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1940644) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1940668..1940675) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1940737..1941081) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" /label="ypuD CDS" gene complement(1940737..1941081) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /label="ypuD gene" downshifts complement(1940752) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1941113..1941131) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1941126) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1941140..1941145 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1941146..1941152) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1941160..1942082 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 1941160 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1941161..1941179 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1941167..1941182) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1941170) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1941172..1941238) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(1941195..1941204) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1941233..1941241) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1941238) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1941255..1941263) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1941316..1941870) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" /label="sipS CDS" gene complement(1941316..1941870) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /label="sipS gene" downshifts complement(1941326) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1941896..1941915) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1941914) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1941916..1942315) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(1941927..1941933) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1942137..1942373 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" /label="ypzC CDS" gene 1942137..1942373 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /label="ypzC gene" CDS complement(1942316..1942522) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" /label="ypzJ CDS" gene complement(1942316..1942522) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /label="ypzJ gene" misc_feature complement(1942555..1942574) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1942577) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="upshifts" CDS complement(1942631..1942885) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" /label="ypuC CDS" gene complement(1942631..1942885) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo /label="ypuC gene" promotor_-35 1942765..1942774 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1942776..1943165) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" /label="ypuC CDS" gene complement(1942776..1943165) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo /label="ypuC gene" S_feature 1942788..1943859 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 1942788..1942807 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1942788 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1943143..1943346) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" /label="ypuB CDS" gene complement(1943143..1943346) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /label="ypuB gene" CDS 1943755..1943871 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" /label="hypothetical protein CDS" gene 1943755..1943871 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo /label="gene" downshifts 1943822 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" /label="downshifts" promotor_-35 1943948..1943957 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1943970..1943989 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1943970 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1944012..1944224 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" /label="ypzD CDS" gene 1944012..1944224 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /label="ypzD gene" downshifts 1944218 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" downshifts complement(1944360) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1944360..1944791) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" /label="ppiB CDS" gene complement(1944360..1944791) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /label="ppiB gene" S_feature complement(1944792..1944878) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(1944861..1944880) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1944878) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1944894..1944899) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1944928..1944937 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1944947..1945044 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 1944947 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1944950..1944965 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1945045..1945917 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" /label="ypuA CDS" gene 1945045..1945917 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /label="ypuA gene" downshifts 1945824 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 1945890 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1945947..1947266) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" /label="lysA CDS" gene complement(1945947..1947266) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /label="lysA gene" downshifts complement(1945967) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1947267..1947331) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(1947327..1947346) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1947331) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1947361..1947368) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1947372..1947990) /gene="spoVAF" /locus_tag="PG10_5'_ext_BSU_23390" /old_locus_tag="BSU_23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /modified_by="User" /translation="MTTSSGKIFRYSCFYFISSDLVSLCASA*SAPGQHEIYRFK*RY AYPDHPADIFS*LRNRVSQNGCHSHTDGFIDSNGFNCRCSDRADCD*GRPFFS*GDSV RLTCGDWNLYDA*L*IKLGKQNEPSCPHDTRCFISYKRARHRIYSANYCHGKHQIPSD TVLMAADSL*RKGAVAGSCPHSETWRKSKTQHRSPQKSLKAAYQFI" /label="PG10_5'_ext_BSU_23390" gene complement(1947372..1947990) /gene="PG10_5'_ext_BSU_23390" /locus_tag="PG10_pseudo_BSU_23390" /old_locus_tag="BSU_23390" /modified_by="User" /label="PG10_5'_ext_BSU_23390" SCAR join(1947976,1947983) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs23" N_region 1947977..1947982 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs23" S_feature complement(<1947983..1947999) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" CDS complement(1948000..1949169) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" /label="dacF CDS" gene complement(1948000..1949169) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /label="dacF gene" promotor_-10 complement(1949198..1949209) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1949213) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1949223..1949229) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1949315) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1949324..1950139) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" /label="pupG CDS" gene complement(1949324..1950139) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /label="pupG gene" CDS complement(1950152..1951336) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" /label="deoB CDS" gene complement(1950152..1951336) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /label="deoB gene" promotor_-10 complement(1951385..1951404) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1951403) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1951405..1951496) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(1951420..1951427) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1951497..1952387) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" /label="ripX CDS" gene complement(1951497..1952387) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /label="ripX gene" CDS complement(1952395..1952622) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" /label="yqzK CDS" gene complement(1952395..1952622) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /label="yqzK gene" promotor_-10 complement(1952525..1952544) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1952536) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1952558..1952565) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1952615) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1952624..1952642) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1952652..1952670) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1952658..1952664) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1952665) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1952687..1952692) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1952747) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" /label="downshifts" CDS complement(1952747..1953196) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" /label="fur CDS" gene complement(1952747..1953196) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /label="fur gene" promotor_-10 complement(1953220..1953239) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(1953230) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="upshifts" S_feature complement(1953232..1953308) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(1953255..1953259) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(1953309..1953953) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" /label="spoIIM CDS" gene complement(1953309..1953953) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /label="spoIIM gene" promotor_-10 complement(1953984..1954002) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(1954001) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="upshifts" promotor_-35 complement(1954017..1954022) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(1954054..1954269) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" /label="yqkK CDS" gene complement(1954054..1954269) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /label="yqkK gene" downshifts complement(1954134) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1954369..1955688) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" /label="mleA CDS" gene complement(1954369..1955688) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /label="mleA gene" downshifts complement(1954376) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" CDS complement(1955706..1957112) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" /label="mleN CDS" gene complement(1955706..1957112) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /label="mleN gene" promotor_-10 complement(1957160..1957179) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1957169) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1957171..1957252) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(1957194..1957201) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1957253..1958680) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" /label="ansB CDS" gene complement(1957253..1958680) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /label="ansB gene" CDS complement(1958725..1959714) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" /label="ansA CDS" gene complement(1958725..1959714) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /label="ansA gene" S_feature complement(1959715..1959794) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(1959776..1959795) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1959794) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1959796..1960116) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(1959810..1959817) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1959835..1959842 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1959855..1959874 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1959857 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="upshifts" CDS 1959896..1960246 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" /label="ansR CDS" gene 1959896..1960246 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /label="ansR gene" S_feature complement(1960118..1960254) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(1960161) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" /label="downshifts" CDS complement(1960255..1961418) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" /label="yqxK CDS" gene complement(1960255..1961418) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /label="yqxK gene" CDS complement(1961415..1961972) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" /label="nudF CDS" gene complement(1961415..1961972) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /label="nudF gene" promotor_no_box complement(1961902..1962002) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1961942) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1961986..1961991 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1962007..1962025 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1962009..1962023) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 1962013 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="upshifts" S_feature 1962020..1962194 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(1962025..1962028) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(1962028) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="upshifts" CDS 1962047..1962169 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" /label="mciZ CDS" gene 1962047..1962169 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /label="mciZ gene" promotor_-35 1962170..1962177 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1962191..1962210 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1962196 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="upshifts" CDS 1962232..1963152 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" /label="yqkF CDS" gene 1962232..1963152 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /label="yqkF gene" downshifts 1963141 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1963184..1963408) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" /label="yqkE CDS" gene complement(1963184..1963408) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /label="yqkE gene" downshifts complement(1963241) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1963431..1963450) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1963438) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1963465..1963472) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1963487..1963494 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1963509..1963528 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1963516 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="upshifts" CDS 1963570..1964487 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" /label="yqkD CDS" gene 1963570..1964487 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /label="yqkD gene" downshifts 1964462 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" /label="downshifts" CDS complement(1964527..1964766) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" /label="yqkC CDS" gene complement(1964527..1964766) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /label="yqkC gene" downshifts complement(1964538) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1964779..1965102) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" /label="yqkB CDS" gene complement(1964779..1965102) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /label="yqkB gene" promotor_-10 complement(1964845..1964864) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1964846) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1964878..1964885) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1965099..1966130) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" /label="yqkA CDS" gene complement(1965099..1966130) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /label="yqkA gene" promotor_-10 complement(1965126..1965145) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1965133) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1965156..1965163) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1966123..1966467) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" /label="yqjZ CDS" gene complement(1966123..1966467) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /label="yqjZ gene" CDS complement(1966477..1966947) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" /label="yqjY CDS" gene complement(1966477..1966947) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /label="yqjY gene" S_feature complement(1966948..1967024) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 1966948 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1966999..1967018) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1967024) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1967026..1967132) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(1967033..1967040) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1967133..1967471) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" /label="yqjX CDS" gene complement(1967133..1967471) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /label="yqjX gene" CDS complement(1967468..1968706) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" /label="polYB CDS" gene complement(1967468..1968706) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /label="polYB gene" misc_feature 1967630..1967631 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1967641 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1967696 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1968731..1968749) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(1968740) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="upshifts" promotor_-35 complement(1968766..1968771) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 1968811..1968814 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1968829..1968848 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1968838 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="upshifts" CDS 1968872..1969078 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" /label="yqzH CDS" gene 1968872..1969078 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /label="yqzH gene" promotor_-35 1969561..1969564 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1969579..1969598 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1969595 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="upshifts" CDS 1969627..1970859 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" /label="yqjV CDS" gene 1969627..1970859 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /label="yqjV gene" CDS 1970706..1971068 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" /label="yqjU CDS" gene 1970706..1971068 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /label="yqjU gene" S_feature complement(1970885..1971064) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(1970918) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1971065..1971451) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" /label="yqjT CDS" gene complement(1971065..1971451) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /label="yqjT gene" CDS complement(1971455..1972414) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" /label="coaA CDS" gene complement(1971455..1972414) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /label="coaA gene" S_feature complement(1972415..1972485) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(1972486..1973832) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" /label="dsdA CDS" gene complement(1972486..1973832) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /label="dsdA gene" S_feature complement(1973833..1973907) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(1973908..1974687) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" /label="yqjQ CDS" gene complement(1973908..1974687) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /label="yqjQ gene" CDS complement(1974693..1975652) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" /label="yqjP CDS" gene complement(1974693..1975652) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /label="yqjP gene" promotor_-10 complement(1975674..1975693) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1975693) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1975708..1975715) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1975749..1975756 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1975770..1976056 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 1975770 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1975772..1975791 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1975786..1976031 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" /label="pswI RNA" gene 1975786..1976031 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /label="pswI gene" CDS 1976057..1976893 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" /label="proI CDS" gene 1976057..1976893 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /label="proI gene" downshifts 1976891 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1976934..1978577) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" /label="yqjN CDS" gene complement(1976934..1978577) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /label="yqjN gene" downshifts complement(1976946) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1978595..1978601 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1978608 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1978615..1978626 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(1978633..1978652) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1978638) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1978684..1978691 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1978705..1978724 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1978707 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 1978749..1979765 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" /label="yqjM CDS" gene 1978749..1979765 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /label="yqjM gene" downshifts 1979752 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 1979814..1979823 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1979836..1979851 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1979840 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 1979875..1980636 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" /label="yqjL CDS" gene 1979875..1980636 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /label="yqjL gene" downshifts 1980544 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 1980632 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1980664..1980864) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(1980680..1980805) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" /label="rpmGCc CDS" gene complement(1980680..1980805) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo /label="rpmGCc gene" downshifts complement(1980707) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1980798..1980830) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" /label="rpmGCn CDS" gene complement(1980798..1980830) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo /label="rpmGCn gene" promotor_-10 complement(1980858..1980877) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1980864) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1980890..1980897) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1980912..1981835) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" /label="rnz CDS" gene complement(1980912..1981835) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /label="rnz gene" promotor_-10 complement(1981861..1981880) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1981874) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1981894..1981899) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1981973..1981980 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1981994..1982013 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1981996..1982061 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 1981996 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="upshifts" CDS 1982062..1983531 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" /label="zwf CDS" gene 1982062..1983531 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /label="zwf gene" downshifts 1983514 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" terminator 1983539..1983578 /created_by="User" /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" /label="Delta6_zwf-T-gndA_Terminator" Polymorphism join(1983551,1983554) /Source="geneious" /ID="SNP_BsDelta6_2480646_2480647" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="TA -> AT" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TA" /Variant_Nucleotides="AT" /Variant_P_Value=0 /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(1983559,1983560) /Source="geneious" /ID="SNP_BsDelta6_2480654_2480654" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.1e-279" /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(1983571,1983572) /Source="geneious" /ID="SNP_BsDelta6_2480667_2480667" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=116 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.9e-244" /Variant_Raw_Frequency=110 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 1983580 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1983654..1985063) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" /label="gndA CDS" gene complement(1983654..1985063) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /label="gndA gene" downshifts complement(1983671) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" downshifts complement(1983744) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" misc_feature complement(1985127..1985145) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1985129) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1985173..1986417) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" /label="polYA CDS" gene complement(1985173..1986417) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /label="polYA gene" S_feature complement(1986418..1986692) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 1986438..1986445 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1986459..1986478 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1986459 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="upshifts" CDS 1986490..1986777 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" /label="mifM CDS" gene 1986490..1986777 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /label="mifM gene" promotor_-10 complement(1986674..1986693) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(1986694) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="upshifts" promotor_-35 complement(1986709..1986712) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 1986808..1987635 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " /label="oxaAB CDS" gene 1986808..1987635 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /label="oxaAB gene" downshifts 1987452 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 1987628 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1987640..1988560) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(1987683) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1987753..1987759 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1987773..1987791 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1987782 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="upshifts" CDS 1987815..1988543 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" /label="yqjF CDS" gene 1987815..1988543 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /label="yqjF gene" CDS complement(1988584..1989699) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" /label="yqjE CDS" gene complement(1988584..1989699) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /label="yqjE gene" downshifts complement(1988605) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" CDS complement(1989717..1991240) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " /label="yqjD CDS" gene complement(1989717..1991240) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /label="yqjD gene" promotor_-10 complement(1990823..1990842) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1990845) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1990857..1990861) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1991233..1991655) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" /label="yqjC CDS" gene complement(1991233..1991655) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /label="yqjC gene" promotor_-35 1991684..1991691 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1991705..1991724 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1991719..1991872 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 1991719 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="upshifts" downshifts 1991829 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" CDS complement(1991857..1992387) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" /label="yqjB CDS" gene complement(1991857..1992387) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /label="yqjB gene" S_feature 1991874..1992509 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(1992404..1992415) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1992411) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1992430..1992436) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1992439..1993407) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" /label="yqjA CDS" gene complement(1992439..1993407) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /label="yqjA gene" downshifts complement(1992455) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1993478..1994200) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" /label="artR CDS" gene complement(1993478..1994200) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /label="artR gene" downshifts complement(1993489) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS complement(1994193..1994852) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" /label="artQ CDS" gene complement(1994193..1994852) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /label="artQ gene" S_feature complement(1994853..1994932) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(1994933..1995700) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" /label="artP CDS" gene complement(1994933..1995700) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /label="artP gene" promotor_-10 complement(1995750..1995769) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1995765) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1995784..1995791) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1995968..1996405) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" /label="brxB CDS" gene complement(1995968..1996405) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /label="brxB gene" downshifts complement(1995977) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1996429..1996448) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(1996450) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="upshifts" promotor_-35 complement(1996463..1996470) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 1996503..1996509 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1996522 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1996524..1996542 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1996566..1997459 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" /label="bmrU CDS" gene 1996566..1997459 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /label="bmrU gene" promotor_-35 1997492..1997499 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1997515..1997534 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1997523 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" CDS 1997560..1998729 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" /label="bmr CDS" gene 1997560..1998729 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /label="bmr gene" downshifts 1998712 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" CDS 1998802..1999638 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" /label="bmrR CDS" gene 1998802..1999638 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /label="bmrR gene" downshifts 1999636 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1999700) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(1999700..2000974) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" /label="bkdB CDS" gene complement(1999700..2000974) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /label="bkdB gene" CDS complement(2000997..2001980) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" /label="bkdAB CDS" gene complement(2000997..2001980) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /label="bkdAB gene" CDS complement(2001994..2002986) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" /label="bkdAA CDS" gene complement(2001994..2002986) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /label="bkdAA gene" CDS complement(2003008..2004432) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" /label="lpdV CDS" gene complement(2003008..2004432) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /label="lpdV gene" CDS complement(2004453..2005544) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" /label="buk CDS" gene complement(2004453..2005544) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /label="buk gene" CDS complement(2005563..2006657) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" /label="bcd CDS" gene complement(2005563..2006657) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /label="bcd gene" CDS complement(2006669..2007568) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" /label="ptb CDS" gene complement(2006669..2007568) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /label="ptb gene" misc_feature complement(2007604..2007623) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2007609) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2007611..2007692) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(2007693..2009771) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" /label="bkdR CDS" gene complement(2007693..2009771) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /label="bkdR gene" promotor_-10 complement(2009831..2009850) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2009848) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2009858..2009865 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2009867..2009870) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2009879..2009898 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2009886 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="upshifts" CDS 2009924..2010160 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" /label="yqzF CDS" gene 2009924..2010160 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /label="yqzF gene" downshifts 2010151 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2010202..2011107) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" /label="mmgF CDS" gene complement(2010202..2011107) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /label="mmgF gene" downshifts complement(2010205) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2011125..2012543) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" /label="mmgE CDS" gene complement(2011125..2012543) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /label="mmgE gene" misc_feature complement(2011420..2011439) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2011437) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2012558..2013676) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" /label="mmgD CDS" gene complement(2012558..2013676) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /label="mmgD gene" CDS complement(2013710..2014849) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" /label="mmgC CDS" gene complement(2013710..2014849) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /label="mmgC gene" CDS complement(2014877..2015740) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" /label="mmgB CDS" gene complement(2014877..2015740) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /label="mmgB gene" CDS complement(2015765..2016946) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" /label="mmgA CDS" gene complement(2015765..2016946) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /label="mmgA gene" downshifts complement(2016526) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" /label="downshifts" misc_feature complement(2016633..2016639) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2016636) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2016860..2016960) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2016900) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2016993..2017011) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2017011) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2017027..2017032) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2017073..2017804) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" /label="glpQ CDS" gene complement(2017073..2017804) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /label="glpQ gene" downshifts complement(2017080) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2017827..2017846) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2017838) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2017861..2017864) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2017883..2018503) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" /label="yqiI CDS" gene complement(2017883..2018503) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /label="yqiI gene" CDS complement(2018518..2018811) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" /label="yqiH CDS" gene complement(2018518..2018811) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /label="yqiH gene" promotor_-10 complement(2018831..2018850) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2018837) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2018865..2018872) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2019067..2019074 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2019088..2019107 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2019105..2019310 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 2019105 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2019119..2019271 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" /label="hypothetical protein CDS" gene 2019119..2019271 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /label="gene" promotor_-35 2019279..2019286 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2019301..2019320 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2019312 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2019344..2020462 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" /label="yqiG CDS" gene 2019344..2020462 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /label="yqiG gene" downshifts 2020447 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2020489..2020659) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(2020532) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2020643..2020658) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2020659) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2020661..2020789) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(2020670..2020679) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2020788..2020807) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2020811) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2020821..2020829) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2020921) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2020927..2021730) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" /label="spo0A CDS" gene complement(2020927..2021730) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /label="spo0A gene" promotor_-10 complement(2021773..2021791) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2021779) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2021781..2021933) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(2021802..2021810) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2021929..2021948) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2021941) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2021960..2021967) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 2021975..2021976 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_005" CDS complement(2022036..2023766) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" /label="recN CDS" gene complement(2022036..2023766) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /label="recN gene" downshifts complement(2022051) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2023803..2024252) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" /label="argR CDS" gene complement(2023803..2024252) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /label="argR gene" S_feature complement(2024253..2024338) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(2024350..2025195) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" /label="yqxC CDS" gene complement(2024350..2025195) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /label="yqxC gene" downshifts complement(2024383) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" /label="downshifts" CDS complement(2025192..2027093) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" /label="dxs CDS" gene complement(2025192..2027093) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /label="dxs gene" promotor_-35 2026301..2026307 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2026322..2026333 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2026330 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2027094..2027222) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(2027217..2027236) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2027222) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2027251..2027257) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2027268..2028158) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" /label="ispA CDS" gene complement(2027268..2028158) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /label="ispA gene" CDS complement(2028148..2028402) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" /label="xseB CDS" gene complement(2028148..2028402) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /label="xseB gene" CDS complement(2028399..2029745) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" /label="xseA CDS" gene complement(2028399..2029745) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /label="xseA gene" S_feature complement(2029746..2029882) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(2029883..2030734) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" /label="folD CDS" gene complement(2029883..2030734) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /label="folD gene" CDS complement(2030746..2031141) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" /label="nusB CDS" gene complement(2030746..2031141) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /label="nusB gene" misc_feature complement(2031184..2031203) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2031203) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2031205..2031367) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(2031405..2031812) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" /label="yqhY CDS" gene complement(2031405..2031812) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /label="yqhY gene" downshifts complement(2031412) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" /label="downshifts" CDS complement(2031833..2033185) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" /label="accC CDS" gene complement(2031833..2033185) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /label="accC gene" promotor_-10 complement(2032714..2032733) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(2032721) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="upshifts" promotor_-35 complement(2032748..2032754) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(2033197..2033676) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " /label="accB CDS" gene complement(2033197..2033676) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /label="accB gene" promotor_-10 complement(2033735..2033754) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2033746) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2033768..2033775) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2033832..2034488) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" /label="spoIIIAH CDS" gene complement(2033832..2034488) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /label="spoIIIAH gene" downshifts complement(2033839) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" CDS complement(2034489..2035178) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" /label="spoIIIAG CDS" gene complement(2034489..2035178) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /label="spoIIIAG gene" CDS complement(2035171..2035791) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" /label="spoIIIAF CDS" gene complement(2035171..2035791) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /label="spoIIIAF gene" promotor_-10 complement(2035497..2035515) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2035515) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2035531..2035536) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2035805..2037004) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" /label="spoIIIAE CDS" gene complement(2035805..2037004) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /label="spoIIIAE gene" CDS complement(2037023..2037424) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" /label="spoIIIAD CDS" gene complement(2037023..2037424) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /label="spoIIIAD gene" CDS complement(2037431..2037637) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" /label="spoIIIAC CDS" gene complement(2037431..2037637) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /label="spoIIIAC gene" CDS complement(2037660..2038175) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" /label="spoIIIAB CDS" gene complement(2037660..2038175) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /label="spoIIIAB gene" CDS complement(2038169..2039092) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" /label="spoIIIAA CDS" gene complement(2038169..2039092) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /label="spoIIIAA gene" S_feature complement(2039093..2039167) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(2039168..2039449) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" /label="yqhV CDS" gene complement(2039168..2039449) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /label="yqhV gene" promotor_-10 complement(2039469..2039487) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(2039492) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="upshifts" promotor_-35 complement(2039503..2039508) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(2039594..2040151) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" /label="efp CDS" gene complement(2039594..2040151) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /label="efp gene" downshifts complement(2039606) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2040176..2041237) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" /label="papA CDS" gene complement(2040176..2041237) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /label="papA gene" CDS complement(2041234..2041680) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" /label="yqhS CDS" gene complement(2041234..2041680) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /label="yqhS gene" promotor_-10 complement(2041729..2041748) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2041745) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2041761..2041768) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2041767..2042303) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" /label="yqhR CDS" gene complement(2041767..2042303) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /label="yqhR gene" promotor_-10 complement(2042316..2042327) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(2042325) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="upshifts" promotor_-35 complement(2042341..2042347) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 2042373..2042379 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2042392 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2042394..2042412 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2042449..2042452 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2042467..2042486 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2042478 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" CDS 2042530..2043486 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" /label="yqhQ CDS" gene 2042530..2043486 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /label="yqhQ gene" CDS 2043526..2043921 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" /label="yqhP CDS" gene 2043526..2043921 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /label="yqhP gene" promotor_no_box 2043804..2043904 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2043864 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2043907 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2043918..2044793) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" /label="yqhO CDS" gene complement(2043918..2044793) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /label="yqhO gene" promotor_-10 complement(2044820..2044838) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2044837) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2044854..2044859) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2044919..2045347) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" /label="mntR CDS" gene complement(2044919..2045347) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /label="mntR gene" downshifts complement(2044946) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2045382..2045401) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2045390) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2045417..2045421) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2045447..2046283) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" /label="lipM CDS" gene complement(2045447..2046283) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /label="lipM gene" promotor_-10 complement(2046307..2046326) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2046318) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2046320..2046864) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(2046340..2046347) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2046364..2046369 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2046383..2046402 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2046383 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="upshifts" S_feature 2046394..2046473 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 2046474..2046854 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" /label="yqhL CDS" gene 2046474..2046854 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /label="yqhL gene" downshifts 2046790 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2046834 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2046889..2048355) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" /label="gcvPB CDS" gene complement(2046889..2048355) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /label="gcvPB gene" downshifts complement(2046909) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" /label="downshifts" CDS complement(2048348..2049694) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" /label="gcvPA CDS" gene complement(2048348..2049694) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /label="gcvPA gene" CDS complement(2049724..2050812) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" /label="gcvT CDS" gene complement(2049724..2050812) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /label="gcvT gene" misc_RNA complement(2050886..2051085) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" /label="swgA RNA" gene complement(2050886..2051085) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /label="swgA gene" downshifts complement(2050936) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" /label="downshifts" S_feature complement(2051086..2051156) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 2051089..2051094 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2051110..2051128 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2051114 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2051124..2051253 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(2051142..2051161) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(2051156) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="upshifts" promotor_-35 complement(2051175..2051182) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 2051254..2052927 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" /label="yqhH CDS" gene 2051254..2052927 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /label="yqhH gene" CDS 2052948..2053742 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" /label="yqhG CDS" gene 2052948..2053742 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /label="yqhG gene" misc_feature 2053278..2053279 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2053284 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="upshifts" promotor_-35 2053766..2053769 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2053785..2053804 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2053786..2053924 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 2053786 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2053925..2054098 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" /label="sinI CDS" gene 2053925..2054098 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /label="sinI gene" promotor_-35 2054083..2054087 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2054100..2054119 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2054100 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2054132..2054467 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" /label="sinR CDS" gene 2054132..2054467 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /label="sinR gene" downshifts 2054444 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts 2054534 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts complement(2054566) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2054583,2054590) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27" N_region 2054584..2054589 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs27" promotor_-35 2054659..2054665 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2054666 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2054679..2054690 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2054709..2055035 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" /label="yqzG CDS" gene 2054709..2055035 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /label="yqzG gene" S_feature complement(2054852..2055076) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(2054895) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2055017 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2055077..2055256) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" /label="spoIIT CDS" gene complement(2055077..2055256) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /label="spoIIT gene" promotor_-10 complement(2055275..2055293) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2055290) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2055308..2055314) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2055327..2055701) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" /label="comGG CDS" gene complement(2055327..2055701) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /label="comGG gene" CDS complement(2055702..2056085) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" /label="comGF CDS" gene complement(2055702..2056085) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /label="comGF gene" CDS complement(2056111..2056458) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" /label="comGE CDS" gene complement(2056111..2056458) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /label="comGE gene" CDS complement(2056442..2056873) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" /label="comGD CDS" gene complement(2056442..2056873) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /label="comGD gene" CDS complement(2056863..2057159) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" /label="comGC CDS" gene complement(2056863..2057159) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /label="comGC gene" CDS complement(2057173..2058144) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" /label="comGB CDS" gene complement(2057173..2058144) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /label="comGB gene" CDS complement(2058197..2059267) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" /label="comGA CDS" gene complement(2058197..2059267) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /label="comGA gene" promotor_-10 complement(2059285..2059304) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2059301) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2059318..2059325) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2059450..2059678) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(2059491) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2059679..2060632) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" /label="yqxL CDS" gene complement(2059679..2060632) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /label="yqxL gene" promotor_-10 complement(2060656..2060675) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2060677) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2060689..2060695) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2060715..2060721 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2060736..2060754 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2060754 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="upshifts" CDS 2060775..2062103 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" /label="yqhB CDS" gene 2060775..2062103 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /label="yqhB gene" S_feature 2062104..2063078 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(2062156..2062992) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" /label="rsbRD CDS" gene complement(2062156..2062992) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /label="rsbRD gene" S_feature complement(2062993..2063177) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 2063079..2063149 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Gln1 tRNA" gene 2063079..2063149 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /label="trnSL-Gln1 gene" CDS complement(2063216..2063596) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" /label="mgsR CDS" gene complement(2063216..2063596) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /label="mgsR gene" downshifts complement(2063222) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2063625..2063643) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2063644) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2063658..2063664) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2063683..2063688 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 2063704..2063722 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 2063713 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="upshifts" promotor_-35 2063763..2063770 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 2063785 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="upshifts" promotor_-10 2063786..2063805 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 2063828..2064073 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" /label="yqgY CDS" gene 2063828..2064073 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /label="yqgY gene" downshifts 2063970 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" /label="downshifts" downshifts 2064059 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" /label="downshifts" S_feature 2064104..2064859 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(2064113..2064748) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" /label="yqgX CDS" gene complement(2064113..2064748) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /label="yqgX gene" downshifts complement(2064138) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2064770..2064789) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2064787) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2064803..2064810) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2064827..2064834 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2064849..2064868 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2064861 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2064881) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2064883..2064897) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2064905..2064909) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2064905..2065078 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" /label="yqgW CDS" gene 2064905..2065078 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /label="yqgW gene" downshifts 2065066 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" /label="downshifts" CDS complement(2065110..2065424) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" /label="yqgV CDS" gene complement(2065110..2065424) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /label="yqgV gene" S_feature 2065111..2066178 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(2065124) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2065427..2066488) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" /label="yqgU CDS" gene complement(2065427..2066488) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /label="yqgU gene" CDS complement(2066550..2067680) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" /label="yqgT CDS" gene complement(2066550..2067680) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /label="yqgT gene" promotor_-10 complement(2067688..2067706) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2067720) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2067722..2067727) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2067763..2069679) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" /label="ltaSC CDS" gene complement(2067763..2069679) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /label="ltaSC gene" downshifts complement(2067790) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" /label="downshifts" promotor_-35 2068795..2068801 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2068814..2069843 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 2068814 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2068817..2068835 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(2069680..2069746) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(2069740..2069759) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2069746) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2069774..2069781) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2069796..2070761) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" /label="glcK CDS" gene complement(2069796..2070761) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /label="glcK gene" CDS complement(2070772..2070987) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" /label="yqgQ CDS" gene complement(2070772..2070987) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /label="yqgQ gene" S_feature complement(2070988..2071096) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(2071097..2072620) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " /label="glpG CDS" gene complement(2071097..2072620) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /label="glpG gene" promotor_-10 complement(2072638..2072657) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2072651) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2072672..2072679) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2072710..2072883) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" /label="yqgO CDS" gene complement(2072710..2072883) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /label="yqgO gene" downshifts complement(2072737) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2072899..2072910) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2072911) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2072924..2072930) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2072950..2073513) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" /label="folN CDS" gene complement(2072950..2073513) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /label="folN gene" S_feature complement(2073514..2073597) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(2073598..2073747) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" /label="rpmGA CDS" gene complement(2073598..2073747) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /label="rpmGA gene" downshifts complement(2073644) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2073784..2073803) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2073794) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2073819..2073822) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2073831..2074910) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" /label="yqgM CDS" gene complement(2073831..2074910) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /label="yqgM gene" CDS complement(2074907..2075377) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" /label="yqgL CDS" gene complement(2074907..2075377) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /label="yqgL gene" promotor_-35 2075322..2075330 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2075344..2075352 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2075345..2075518 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 2075346 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2075413..2075432) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2075425) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2075444..2075451) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2075490..2075494 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2075510..2075529 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2075520 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" CDS 2075557..2075910 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" /label="yqzD CDS" gene 2075557..2075910 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /label="yqzD gene" CDS 2075907..2076371 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" /label="yqzC CDS" gene 2075907..2076371 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /label="yqzC gene" downshifts 2076357 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2076400..2077182) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" /label="pstBB CDS" gene complement(2076400..2077182) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /label="pstBB gene" downshifts complement(2076411) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2077193..2078002) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" /label="pstBA CDS" gene complement(2077193..2078002) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /label="pstBA gene" CDS complement(2078023..2078907) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" /label="pstA CDS" gene complement(2078023..2078907) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /label="pstA gene" CDS complement(2078907..2079836) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" /label="pstC CDS" gene complement(2078907..2079836) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /label="pstC gene" CDS complement(2079905..2080807) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" /label="pstS CDS" gene complement(2079905..2080807) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /label="pstS gene" upshifts complement(2080862) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2080870..2080886) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2080897..2080899) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" Polymorphism join(2080916,2080918) /Source="geneious" /ID="SNP_BsDelta6_2581727_2581726" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)6 -> (T)7" /Codon_Change /Coverage=117 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=114 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2080962..2083112) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" /label="pbpA CDS" gene complement(2080962..2083112) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /label="pbpA gene" downshifts complement(2080972) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2081706..2081724) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2081714) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2081740..2081746) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2082401..2082420) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2082418) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2082434..2082443) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2083162..2083181) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2083167) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2083197..2083201) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2083226..2084518) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" /label="yqgE CDS" gene complement(2083226..2084518) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /label="yqgE gene" promotor_-10 complement(2084541..2084552) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2084552) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2084566..2084572) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2084625..2085233) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" /label="sodA CDS" gene complement(2084625..2085233) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /label="sodA gene" downshifts complement(2084640) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2085285..2085304) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2085296) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2085298..2085366) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(2085319..2085326) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2085357..2085375) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2085366) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2085390..2085396) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2085412..2085894) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" /label="yqgC CDS" gene complement(2085412..2085894) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /label="yqgC gene" S_feature complement(2085895..2086187) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 2085937..2085943 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2085958..2085977 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2085971 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="upshifts" CDS 2086004..2086771 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" /label="yqgB CDS" gene 2086004..2086771 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /label="yqgB gene" promotor_-10 complement(2086185..2086203) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(2086187) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="upshifts" S_feature complement(2086189..2087125) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(2086217..2086223) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 2086772..2087202 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 2087159 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(2087170) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" CDS complement(2087187..2087615) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" /label="yqgA CDS" gene complement(2087187..2087615) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /label="yqgA gene" promotor_-35 2087611..2087615 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 2087625..2087639 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 2087634 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="upshifts" promotor_-10 complement(2087638..2087657) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(2087661) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="upshifts" promotor_-35 complement(2087672..2087679) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 2087830..2087835 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2087851..2087869 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2087863 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2087892..2088191 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" /label="yqfZ CDS" gene 2087892..2088191 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /label="yqfZ gene" promotor_-35 2088204..2088211 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2088226..2088245 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2088237..2088313 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 2088237 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2088314..2089447 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" /label="ispG CDS" gene 2088314..2089447 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /label="ispG gene" downshifts 2089428 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(2089473..2089862) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" /label="yqfX CDS" gene complement(2089473..2089862) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /label="yqfX gene" downshifts complement(2089499) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2089893..2089904) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2089897) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2089918..2089924) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2089937..2089944 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2089955..2089974 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2089956 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="upshifts" CDS 2089995..2090576 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" /label="yqfW CDS" gene 2089995..2090576 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /label="yqfW gene" downshifts 2090574 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" /label="downshifts" S_feature 2090619..2091227 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(2090619..2091056) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" /label="zur CDS" gene complement(2090619..2091056) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /label="zur gene" downshifts complement(2090623) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2091057..2091151) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(2091147..2091166) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2091151) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2091181..2091188) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2091194..2092075) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" /label="yqfU CDS" gene complement(2091194..2092075) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /label="yqfU gene" promotor_-35 2092071..2092076 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2092092..2092110 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2092108 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2092113..2092132) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2092119) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2092121..2092448) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 2092137..2092146 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2092153 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2092159..2092178 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2092191..2092445 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" /label="yqfT CDS" gene 2092191..2092445 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /label="yqfT gene" downshifts 2092432 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2092472..2093365) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" /label="nfo CDS" gene complement(2092472..2093365) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /label="nfo gene" S_feature 2092477..2093278 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2092493) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" /label="downshifts" CDS complement(2093375..2094691) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" /label="cshB CDS" gene complement(2093375..2094691) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /label="cshB gene" promotor_-10 complement(2094727..2094746) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2094738) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2094762..2094766) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2094795..2094804 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2094816 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2094818..2094837 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2094860..2095603 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" /label="yqfQ CDS" gene 2094860..2095603 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /label="yqfQ gene" downshifts 2095585 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" promotor_-35 2095607..2095614 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2095628..2095647 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2095630..2095725 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2095630 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="upshifts" CDS 2095726..2096670 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" /label="ispH CDS" gene 2095726..2096670 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /label="ispH gene" downshifts 2096641 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2096693..2097814) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" /label="yqfO CDS" gene complement(2096693..2097814) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /label="yqfO gene" downshifts complement(2096718) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2097807..2098457) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" /label="trmK CDS" gene complement(2097807..2098457) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /label="trmK gene" S_feature complement(2098458..2098566) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2098554..2098573) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2098566) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2098568..2098681) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2098589..2098593) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2098714..2099076) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" /label="cccA CDS" gene complement(2098714..2099076) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /label="cccA gene" downshifts complement(2098726) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-35 2099072..2099076 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2099084..2099098 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2099105 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2099113..2099132) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2099115) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2099117..2099238) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2099144..2099151) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2099227..2099246) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2099235..2099254 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2099238) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2099240..2099379) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2099241..2099345 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2099241 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2099260..2099266) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2099309..2099316 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2099330..2099349 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2099347..2101496 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2099347 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2099405..2100520) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" /label="sigA CDS" gene complement(2099405..2100520) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /label="sigA gene" downshifts complement(2099424) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" /label="downshifts" S_feature complement(2100521..2100718) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2100719..2102530) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" /label="dnaG CDS" gene complement(2100719..2102530) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /label="dnaG gene" promotor_-35 2102125..2102131 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2102141 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2102143..2102162 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2102170..2102466 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" /label="antE CDS" gene 2102170..2102466 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /label="antE gene" CDS complement(2102564..2103058) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" /label="yqxD CDS" gene complement(2102564..2103058) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /label="yqxD gene" promotor_-10 complement(2103031..2103049) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2103042) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2103059..2103172) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2103061..2103069) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2103067..2103072 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2103088..2103106 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2103103 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2103157..2103175) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2103172) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2103174..2103251) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2103191..2103196) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2103217..2103236) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2103251) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2103252..2103255) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2103312..2104124) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" /label="ppsR CDS" gene complement(2103312..2104124) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /label="ppsR gene" CDS complement(2104150..2104788) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" /label="ccpN CDS" gene complement(2104150..2104788) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /label="ccpN gene" S_feature complement(2104789..2104920) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2104914..2104933) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2104921..2106960) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" /label="glyS CDS" gene complement(2104921..2106960) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /label="glyS gene" upshifts complement(2104923) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2104948..2104955) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2104967) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" downshifts complement(2105033) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" /label="downshifts" CDS complement(2106953..2107840) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" /label="glyQ CDS" gene complement(2106953..2107840) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /label="glyQ gene" misc_RNA complement(2107923..2108097) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" /label="tboG RNA" gene complement(2107923..2108097) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /label="tboG gene" downshifts complement(2107957) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" /label="downshifts" promotor_-35 2108072..2108077 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2108093..2108111 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2108101..2108120) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2108103..2109515 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2108103 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2108113) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2108135..2108142) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2108137..2108904) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" /label="recO CDS" gene complement(2108137..2108904) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /label="recO gene" CDS complement(2108941..2109084) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" /label="yqzL CDS" gene complement(2108941..2109084) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /label="yqzL gene" S_feature complement(2109085..2109231) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2109232..2110137) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" /label="era CDS" gene complement(2109232..2110137) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /label="era gene" CDS complement(2110118..2110528) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" /label="cdd CDS" gene complement(2110118..2110528) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /label="cdd gene" promotor_-10 complement(2110566..2110585) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2110577) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2110579..2110646) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2110600..2110603) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2110647..2111018) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" /label="unpK CDS" gene complement(2110647..2111018) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /label="unpK gene" CDS complement(2110999..2111472) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" /label="rnrY CDS" gene complement(2110999..2111472) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /label="rnrY gene" CDS complement(2111473..2113608) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" /label="pgpH CDS" gene complement(2111473..2113608) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /label="pgpH gene" promotor_-35 2113452..2113457 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2113472 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2113473..2113491 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2113687..2114646) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" /label="phoH CDS" gene complement(2113687..2114646) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /label="phoH gene" downshifts complement(2113702) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" CDS complement(2114643..2115839) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" /label="yqfD CDS" gene complement(2114643..2115839) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /label="yqfD gene" promotor_-10 complement(2114710..2114729) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2114715) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2114743..2114750) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2114790..2114808) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2114802) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="upshifts" promotor_-35 complement(2114823..2114829) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2115017) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="upshifts" promotor_-10 complement(2115031..2115042) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2115057..2115063) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2115858..2116139) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" /label="yqfC CDS" gene complement(2115858..2116139) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /label="yqfC gene" CDS complement(2116196..2116615) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" /label="yqfB CDS" gene complement(2116196..2116615) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /label="yqfB gene" downshifts complement(2116210) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2116640..2117635) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" /label="floA CDS" gene complement(2116640..2117635) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /label="floA gene" CDS complement(2117657..2118970) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" /label="nfeDA CDS" gene complement(2117657..2118970) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /label="nfeDA gene" promotor_-10 complement(2119006..2119021) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2119023) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="upshifts" promotor_-35 complement(2119034..2119043) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2119101..2119547) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" /label="yqeY CDS" gene complement(2119101..2119547) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /label="yqeY gene" downshifts complement(2119114) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" downshifts complement(2119312) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(2119562..2119735) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" /label="rpsU CDS" gene complement(2119562..2119735) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /label="rpsU gene" misc_feature 2119671..2119675 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2119676 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2119796..2119815) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2119811) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2119829..2119836) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2119854..2119859 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2119874 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2119875..2119893 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2119908..2120831 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" /label="yqeW CDS" gene 2119908..2120831 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /label="yqeW gene" CDS complement(2120868..2122223) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" /label="mtaB CDS" gene complement(2120868..2122223) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /label="mtaB gene" downshifts complement(2120874) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2122223..2122993) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" /label="rsmE CDS" gene complement(2122223..2122993) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /label="rsmE gene" CDS complement(2123016..2123951) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" /label="prmA CDS" gene complement(2123016..2123951) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /label="prmA gene" CDS complement(2123976..2125103) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" /label="dnaJ CDS" gene complement(2123976..2125103) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /label="dnaJ gene" misc_feature 2125020..2125023 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2125031 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2125104..2125281) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2125143..2125233 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surC RNA" gene 2125143..2125233 /gene="surC" /locus_tag="BSU_misc_RNA_79" /label="surC gene" CDS complement(2125303..2127138) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" /label="dnaK CDS" gene complement(2125303..2127138) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /label="dnaK gene" downshifts complement(2125326) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" /label="downshifts" CDS complement(2127162..2127725) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" /label="grpE CDS" gene complement(2127162..2127725) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /label="grpE gene" S_feature complement(2127726..2127796) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2127797..2128828) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" /label="hrcA CDS" gene complement(2127797..2128828) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /label="hrcA gene" promotor_-10 complement(2128869..2128888) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2128882) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2128903..2128910) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2128909..2130048) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" /label="hemN CDS" gene complement(2128909..2130048) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /label="hemN gene" promotor_-10 complement(2129921..2129932) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2129925) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="upshifts" promotor_-35 complement(2129946..2129952) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2130101..2131939) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" /label="lepA CDS" gene complement(2130101..2131939) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /label="lepA gene" downshifts complement(2130123) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2131974..2131993) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2131991) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2132009..2132013) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2132073..2132411) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" /label="yqxA CDS" gene complement(2132073..2132411) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /label="yqxA gene" downshifts complement(2132079) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2132428..2133633) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" /label="spoIIP CDS" gene complement(2132428..2133633) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /label="spoIIP gene" promotor_-10 complement(2133653..2133671) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2133665) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2133687..2133692) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2133696..2134802) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" /label="gpr CDS" gene complement(2133696..2134802) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /label="gpr gene" promotor_-10 complement(2134830..2134841) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2134837) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2134856..2134862) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2134901..2134904 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2134917 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2134920..2134939 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2134931..2135005 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2135006..2135272 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" /label="rpsT CDS" gene 2135006..2135272 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /label="rpsT gene" downshifts 2135261 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2135287..2136330) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" /label="holA CDS" gene complement(2135287..2136330) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /label="holA gene" downshifts complement(2135332) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2136359..2136378) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2136370..2136519) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" /label="hypothetical protein CDS" gene complement(2136370..2136519) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /label="gene" upshifts complement(2136371) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2136392..2136396) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2136394..2136733) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2136437) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" /label="downshifts" promotor_-35 2136506..2136512 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2136526..2136545 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2136527 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="upshifts" CDS 2136560..2136694 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" /label="yqzM CDS" gene 2136560..2136694 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /label="yqzM gene" downshifts 2136688 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" /label="downshifts" CDS complement(2136734..2139064) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" /label="comEC CDS" gene complement(2136734..2139064) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /label="comEC gene" promotor_-10 complement(2136751..2136770) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2136767) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2136784..2136793) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2139068..2139637) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" /label="comEB CDS" gene complement(2139068..2139637) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /label="comEB gene" promotor_-10 complement(2139664..2139683) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2139674) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2139698..2139705) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2139704..2140321) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" /label="comEA CDS" gene complement(2139704..2140321) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /label="comEA gene" promotor_-35 2140342..2140347 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2140359 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2140363..2140381 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2140382..2140396) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2140384) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2140386..2141233) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2140405..2140409) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2140405..2141226 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" /label="comER CDS" gene 2140405..2141226 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /label="comER gene" promotor_-10 complement(2141221..2141240) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2141227..2141307 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2141234) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2141254..2141261) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2141267 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2141292..2142035) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" /label="yqeM CDS" gene complement(2141292..2142035) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /label="yqeM gene" downshifts complement(2141322) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2142032..2142388) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" /label="rsfS CDS" gene complement(2142032..2142388) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /label="rsfS gene" CDS complement(2142406..2142966) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" /label="yqeK CDS" gene complement(2142406..2142966) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /label="yqeK gene" CDS complement(2142956..2143525) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" /label="nadD CDS" gene complement(2142956..2143525) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /label="nadD gene" CDS complement(2143537..2143827) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" /label="yqeI CDS" gene complement(2143537..2143827) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /label="yqeI gene" CDS complement(2143821..2144663) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" /label="aroE CDS" gene complement(2143821..2144663) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /label="aroE gene" downshifts 2144655 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" /label="downshifts" CDS complement(2144681..2145781) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" /label="rgpH CDS" gene complement(2144681..2145781) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /label="rgpH gene" CDS complement(2145785..2146303) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" /label="yqeG CDS" gene complement(2145785..2146303) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /label="yqeG gene" promotor_-10 complement(2146213..2146230) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2146227) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2146246..2146249) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2146304..2146865) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2146337) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" /label="downshifts" promotor_-35 2146528..2146535 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2146546..2146646 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2146546..2146565 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2146546 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(2146596..2146854) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sdaM RNA" gene complement(2146596..2146854) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /label="sdaM gene" CDS 2146647..2146805 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" /label="sda CDS" gene 2146647..2146805 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /label="sda gene" S_feature 2146806..2147052 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2146853..2146872) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2146864) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2146888..2146892) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2146916..2147063) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2146953) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2147009 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 2147054..>2147131 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2147058..2147077) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2147063) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2147090..2147099) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2147131,2147133) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_003" N_region 2147132 /note="inserted C residue" /created_by="User" /modified_by="User" /label="IIG_Bs27_003" S_feature <2147133..2147575 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" CDS complement(2147146..2147562) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" /label="psiE CDS" gene complement(2147146..2147562) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /label="psiE gene" CDS complement(2147608..2148906) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" /label="yrkQ CDS" gene complement(2147608..2148906) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /label="yrkQ gene" CDS complement(2148893..2149588) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" /label="yrkP CDS" gene complement(2148893..2149588) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /label="yrkP gene" misc_feature complement(2149654..2149671) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2149663) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2149749..2149755 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2149762..2149780 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2149777 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2149856..2151073 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" /label="yrkO CDS" gene 2149856..2151073 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /label="yrkO gene" promotor_-35 2150315..2150322 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2150337..2150356 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2150353 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2150992..2151240 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" /label="hypothetical protein CDS" gene 2150992..2151240 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /label="gene" S_feature complement(2151169..2152216) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2151585..2152142 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" /label="yrkN CDS" gene 2151585..2152142 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /label="yrkN gene" S_feature 2152143..2152265 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2152218..2152632) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2152261) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" CDS complement(2152633..2153157) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" /label="yrkL CDS" gene complement(2152633..2153157) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /label="yrkL gene" promotor_-35 2153005..2153012 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2153023..2153042 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2153037 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2153158..2153245) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2153240..2153259) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2153245) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2153247..>2153383) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2153274..2153281) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2153383,2153390) /created_by="User" /note="deletion occured in betwen marked nucleotides " /modified_by="User" /label="IIG_Bs12" N_region 2153384..2153389 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs12" CDS complement(2153442..2153972) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" /label="sigZ CDS" gene complement(2153442..2153972) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /label="sigZ gene" promotor_-10 complement(2154018..2154037) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2154041) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2154051..2154058) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2154107..2155087 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" /label="yrpG CDS" gene 2154107..2155087 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /label="yrpG gene" CDS complement(2155361..2156677) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" /label="yraO CDS" gene complement(2155361..2156677) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /label="yraO gene" S_feature complement(2156678..2156791) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2156792..2157661) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" /label="yraN CDS" gene complement(2156792..2157661) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /label="yraN gene" promotor_-10 complement(2157684..2157703) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2157701) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2157718..2157723) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2157768..2157769) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2157776) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2157806..2157807) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2157806..2158909 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" /label="prpF CDS" gene 2157806..2158909 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /label="prpF gene" misc_feature 2158799..2158818 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2158805 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2159156) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" /label="downshifts" CDS complement(2159182..2160015) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" /label="csn CDS" gene complement(2159182..2160015) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /label="csn gene" misc_feature complement(2160045..2160064) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2160054) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2160220..2160224 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2160235..2160457 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2160235 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2160239..2160258 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2160458..2160721 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" /label="yraL CDS" gene 2160458..2160721 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /label="yraL gene" downshifts 2160709 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS 2160858..2161673 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" /label="yraK CDS" gene 2160858..2161673 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /label="yraK gene" S_feature complement(2162008..2162080) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2162051) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2162081..2162437) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" /label="yraJ CDS" gene complement(2162081..2162437) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /label="yraJ gene" CDS complement(2162490..2162849) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" /label="yraI CDS" gene complement(2162490..2162849) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /label="yraI gene" misc_feature complement(2162942..2162961) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2162952) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2163121..2163222) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" /label="hypothetical protein CDS" gene complement(2163121..2163222) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /label="gene" S_feature complement(2163262..2163364) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2163304) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2163365..2163751) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" /label="yraH CDS" gene complement(2163365..2163751) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /label="yraH gene" misc_feature complement(2163793..2163809) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2163809) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2163942..2163948 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2163963..2163974 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2163963 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="upshifts" CDS 2164000..2164245 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" /label="yraG CDS" gene 2164000..2164245 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /label="yraG gene" CDS 2164263..2164631 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" /label="yraF CDS" gene 2164263..2164631 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /label="yraF gene" CDS 2164650..2165786 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" /label="adhB CDS" gene 2164650..2165786 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /label="adhB gene" CDS 2165805..2166002 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" /label="yraE CDS" gene 2165805..2166002 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /label="yraE gene" CDS 2166018..2166317 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" /label="yraD CDS" gene 2166018..2166317 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /label="yraD gene" downshifts 2166308 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2166580..2167002) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" /label="adhR CDS" gene complement(2166580..2167002) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /label="adhR gene" promotor_-35 2167000..2167003 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2167019..2167038 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2167034..2167184 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2167034 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="upshifts" promotor_-10 complement(2167037..2167056) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2167044) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2167070..2167077) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2167153..2167172) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2167161) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="upshifts" CDS 2167185..2167379 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" /label="yrzP CDS" gene 2167185..2167379 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /label="yrzP gene" promotor_-35 complement(2167187..2167194) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2167397..2167404 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2167420..2167439 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2167424 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="upshifts" S_feature 2167425..2167509 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2167510..2168559 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" /label="adhA CDS" gene 2167510..2168559 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /label="adhA gene" promotor_-35 2168627..2168634 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2168649..2168668 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2168662 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="upshifts" CDS 2168690..2169199 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" /label="sufL CDS" gene 2168690..2169199 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /label="sufL gene" downshifts 2169168 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" /label="downshifts" S_feature 2169213..2170318 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2169241..2171274) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" /label="sacC CDS" gene complement(2169241..2171274) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /label="sacC gene" downshifts complement(2169266) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2171183..2171350) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" /label="hypothetical protein CDS" gene complement(2171183..2171350) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /label="gene" S_feature complement(2171275..2171430) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2171431..2172258) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " /label="levG CDS" gene complement(2171431..2172258) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /label="levG gene" CDS complement(2172279..2173088) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" /label="levF CDS" gene complement(2172279..2173088) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /label="levF gene" CDS complement(2173105..2173593) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" /label="levE CDS" gene complement(2173105..2173593) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /label="levE gene" CDS complement(2173593..2174033) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" /label="levD CDS" gene complement(2173593..2174033) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /label="levD gene" downshifts 2174030 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" /label="downshifts" misc_feature complement(2174070..2174088) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2174074) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2174223..2177030) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" /label="levR CDS" gene complement(2174223..2177030) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /label="levR gene" misc_feature complement(2177246..2177265) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2177252) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="upshifts" CDS 2177577..2177717 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" /label="hypothetical protein CDS" gene 2177577..2177717 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /label="gene" misc_feature 2177698..2177717 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2177708 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="upshifts" CDS 2177756..2179144 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" /label="aapA CDS" gene 2177756..2179144 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /label="aapA gene" downshifts 2179133 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(2179166..2179239) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2179208) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2179240..2179872) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" /label="yrhP CDS" gene complement(2179240..2179872) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /label="yrhP gene" downshifts complement(2179296) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2179926..2179945) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2179937) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2179951..2179957 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2179960..2179967) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2179971..2179990 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2179976 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="upshifts" CDS 2180025..2180852 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " /label="yrhO CDS" gene 2180025..2180852 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /label="yrhO gene" downshifts 2180848 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2180965..2180974 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2180987..2181002 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2180992 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="upshifts" CDS 2181048..2181548 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" /label="sigV CDS" gene 2181048..2181548 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /label="sigV gene" CDS 2181548..2182405 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" /label="rsiV CDS" gene 2181548..2182405 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /label="rsiV gene" promotor_-10 complement(2182423..2182434) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2182442) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2182449..2182455) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2182516..2184420 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" /label="oatA CDS" gene 2182516..2184420 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /label="oatA gene" promotor_-35 2184501..2184507 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2184523..2184541 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2184529 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="upshifts" CDS 2184554..2184844 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" /label="yrhK CDS" gene 2184554..2184844 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /label="yrhK gene" S_feature 2184845..2184960 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2184942..2184949 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2184962..2185087 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2184962 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2184963..2184981 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2184981..2185081 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" /label="surF RNA" gene 2184981..2185081 /gene="surF" /locus_tag="BSU_misc_RNA_82" /label="surF gene" downshifts 2185044 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(2185088..2188252) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" /label="cypB CDS" gene complement(2185088..2188252) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /label="cypB gene" downshifts complement(2185104) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2186238..2186247 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2186261..2186280 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2186282 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2188268..2188852) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" /label="bscR CDS" gene complement(2188268..2188852) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /label="bscR gene" CDS complement(2189075..2189617) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" /label="yrhH CDS" gene complement(2189075..2189617) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /label="yrhH gene" S_feature complement(2189618..2189703) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2189701..2189716) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2189703) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2189729..2189738) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2189772..2189988) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2189806..2189964) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" /label="hypothetical protein CDS" gene complement(2189806..2189964) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /label="gene" downshifts complement(2189815) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2189986..2190005) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2189988) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2189990..2190120) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2190019..2190028) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2190121..2190270) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" /label="yrzI CDS" gene complement(2190121..2190270) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /label="yrzI gene" downshifts 2190264 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" /label="downshifts" S_feature complement(2190271..2190361) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2190363..2190582) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2190406) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" downshifts 2190528 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2190561..2190580) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2190582) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2190584..2190659) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2190595..2190602) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2190660..2191460) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" /label="yrhG CDS" gene complement(2190660..2191460) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /label="yrhG gene" S_feature complement(2191529..2191682) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2191572) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2191673..2191692) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2191682) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="upshifts" promotor_-35 complement(2191707..2191713) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2191723..2192091) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" /label="yrhF CDS" gene complement(2191723..2192091) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /label="yrhF gene" S_feature complement(2192092..2192188) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2192174..2192193) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2192178..2192181 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2192194) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="upshifts" promotor_-10 2192197..2192216 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2192199 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="upshifts" S_feature 2192200..2192406 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2192209..2192213) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2192407..2195349 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" /label="yrhE CDS" gene 2192407..2195349 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /label="yrhE gene" CDS 2195368..2195850 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" /label="yrhD CDS" gene 2195368..2195850 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /label="yrhD gene" downshifts 2195830 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2195886..2196116) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" /label="yrhC CDS" gene complement(2195886..2196116) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /label="yrhC gene" downshifts complement(2195906) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2196117..2196198) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2196199..2197338) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" /label="mccB CDS" gene complement(2196199..2197338) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /label="mccB gene" CDS complement(2197340..2198263) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" /label="mccA CDS" gene complement(2197340..2198263) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /label="mccA gene" downshifts complement(2198256) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" /label="downshifts" S_feature complement(2198264..2198327) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2198328..2199023) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" /label="mtnN CDS" gene complement(2198328..2199023) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /label="mtnN gene" promotor_-10 complement(2198763..2198782) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2198781) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2198795..2198804) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2199044..2199685) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" /label="yrrT CDS" gene complement(2199044..2199685) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /label="yrrT gene" promotor_-10 complement(2199252..2199271) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2199271) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2199288..2199291) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2199737..2199746 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2199743..2199762) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2199749) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2199759..2199778 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2199768..2199832 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2199768 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2199778..2199781) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2199813..2199820 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2199834 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2199836..2199853 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2199878..2200081 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" /label="yrzA CDS" gene 2199878..2200081 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /label="yrzA gene" downshifts 2200088 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2200118..2200819) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" /label="yrrS CDS" gene complement(2200118..2200819) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /label="yrrS gene" downshifts complement(2200130) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2200884..2202638) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" /label="pbpI CDS" gene complement(2200884..2202638) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /label="pbpI gene" misc_feature complement(2200912..2200931) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2200922) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2201953..2201968) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2201956) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2201981..2201990) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2202184..2202202) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2202198) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2202217..2202224 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2202217..2202222) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2202239..2202258 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2202244 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2202692..2203165) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" /label="greA CDS" gene complement(2202692..2203165) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /label="greA gene" downshifts complement(2202699) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(2203166..2203298) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2203280..2203299) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2203298) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2203300..2203408) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2203313..2203320) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2203401..2203420) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2203408) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2203416..2204051) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" /label="udk CDS" gene complement(2203416..2204051) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /label="udk gene" promotor_-35 complement(2203436..2203440) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2203546..2203551 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2203567..2203585 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2203574 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2204058..2205326) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" /label="yrrO CDS" gene complement(2204058..2205326) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /label="yrrO gene" CDS complement(2205345..2206274) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" /label="yrrN CDS" gene complement(2205345..2206274) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /label="yrrN gene" CDS complement(2206280..2206933) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " /label="yrrM CDS" gene complement(2206280..2206933) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /label="yrrM gene" S_feature complement(2206934..2207038) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2207020..2207039) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2207038) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2207055..2207059) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2207085..2208167) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" /label="yrrL CDS" gene complement(2207085..2208167) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /label="yrrL gene" downshifts complement(2207119) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2208183..2208202) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2208203) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2208217..2208220) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2208293) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2208298..2208579) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" /label="yrzB CDS" gene complement(2208298..2208579) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /label="yrzB gene" downshifts complement(2208358) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2208597..2209013) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" /label="rimF CDS" gene complement(2208597..2209013) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /label="rimF gene" promotor_-10 complement(2208845..2208863) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2208864) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2208879..2208884) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2209021..2209287) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" /label="yrzL CDS" gene complement(2209021..2209287) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /label="yrzL gene" promotor_-35 2209175..2209183 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2209198..2209217 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2209206..2210395 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2209206 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2209288..2209348) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2209342..2209361) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2209348) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2209372..2212008) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" /label="alaS CDS" gene complement(2209372..2212008) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /label="alaS gene" promotor_-35 complement(2209375..2209382) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2211774..2211792) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2211790) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2211806..2211813) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2212009..2212087) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2212088..2212295) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboA RNA" gene complement(2212088..2212295) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /label="tboA gene" promotor_-10 complement(2212303..2212322) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2212318) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2212337..2212344) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2212339..2213400) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" /label="yrrI CDS" gene complement(2212339..2213400) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /label="yrrI gene" promotor_-35 2213309..2213314 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2213320..2213555 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2213321 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2213330..2213348 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2213417..2213428) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2213418) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2213442..2213448) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2213556..2214284 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" /label="glnQ CDS" gene 2213556..2214284 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /label="glnQ gene" downshifts complement(2214012) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" CDS 2214306..2215127 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" /label="glnH CDS" gene 2214306..2215127 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /label="glnH gene" CDS 2215188..2215838 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" /label="glnM CDS" gene 2215188..2215838 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /label="glnM gene" CDS 2215855..2216511 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" /label="glnP CDS" gene 2215855..2216511 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /label="glnP gene" downshifts 2216510 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2216546..2216677) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " /label="yrzQ CDS" gene complement(2216546..2216677) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /label="yrzQ gene" downshifts complement(2216564) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2216699..2216890) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" /label="yrzR CDS" gene complement(2216699..2216890) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /label="yrzR gene" CDS complement(2216902..2217426) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" /label="yrrD CDS" gene complement(2216902..2217426) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /label="yrrD gene" upshifts complement(2217013) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2217017..2217028) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2217043..2217049) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2217397..2217408) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2217403) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2217423..2217429) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2217484..2219880) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" /label="recDB CDS" gene complement(2217484..2219880) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /label="recDB gene" downshifts complement(2217510) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2217730..2217736 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2217744 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2217751..2217762 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2217764..2218113 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2217865) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" /label="downshifts" CDS complement(2219905..2220525) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" /label="yrrB CDS" gene complement(2219905..2220525) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /label="yrrB gene" CDS complement(2220611..2221726) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" /label="mnmA CDS" gene complement(2220611..2221726) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /label="mnmA gene" downshifts complement(2220612) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" CDS complement(2221757..2222896) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" /label="iscSA CDS" gene complement(2221757..2222896) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /label="iscSA gene" promotor_-10 complement(2222463..2222482) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2222475) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2222496..2222503) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2222915..2223331) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" /label="cymR CDS" gene complement(2222915..2223331) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /label="cymR gene" S_feature complement(2223332..2223429) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2223414..2223433) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2223429) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2223449..2223452) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2223477..2223484 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2223498..2223517 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2223506 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="upshifts" CDS 2223534..2224799 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" /label="rarA CDS" gene 2223534..2224799 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /label="rarA gene" downshifts 2224798 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2224841..2225605) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" /label="tcdA CDS" gene complement(2224841..2225605) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /label="tcdA gene" downshifts complement(2224859) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2225689..2225889) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" /label="ssrSB RNA" gene complement(2225689..2225889) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /label="ssrSB gene" downshifts complement(2225707) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" /label="downshifts" upshifts 2225876 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2225877..2225886 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2225887..2225906) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2225898) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2225919..2225926) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2225941..2227719) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" /label="aspS CDS" gene complement(2225941..2227719) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /label="aspS gene" CDS complement(2227733..2229007) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" /label="hisS CDS" gene complement(2227733..2229007) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /label="hisS gene" misc_RNA complement(2229097..2229329) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" /label="tboH RNA" gene complement(2229097..2229329) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /label="tboH gene" downshifts complement(2229127) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2229339..2229342 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2229353..2229372) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2229357..2229376 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2229359..2229643 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2229359 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2229372) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2229387..2229394) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2229389..2229559) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" /label="yrzK CDS" gene complement(2229389..2229559) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /label="yrzK gene" promotor_-10 complement(2229590..2229601) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2229607) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="upshifts" promotor_-35 complement(2229616..2229622) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2229619..2229626 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2229640..2229658 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2229645 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2229692..2231248 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" /label="yrvJ CDS" gene 2229692..2231248 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /label="yrvJ gene" downshifts 2231227 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2231275..2231673) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" /label="dtd CDS" gene complement(2231275..2231673) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /label="dtd gene" downshifts complement(2231283) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2231727..2233931) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" /label="rsh CDS" gene complement(2231727..2233931) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /label="rsh gene" promotor_-10 complement(2233960..2233979) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2233967) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2233969..2234059) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2233994..2234001) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2234023 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" /label="downshifts" CDS complement(2234099..2234611) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" /label="apt CDS" gene complement(2234099..2234611) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /label="apt gene" downshifts complement(2234104) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" CDS complement(2234617..2236977) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" /label="recJ CDS" gene complement(2234617..2236977) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /label="recJ gene" promotor_-10 complement(2235081..2235100) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2235089) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2235114..2235123) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2236991..2237010) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2237002) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2237025..2237031) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2237044..2237367) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" /label="yrvD CDS" gene complement(2237044..2237367) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /label="yrvD gene" promotor_-10 complement(2237388..2237406) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2237399) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2237421..2237427) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2237443..2237940) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" /label="yrvC CDS" gene complement(2237443..2237940) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /label="yrvC gene" S_feature complement(2237941..2238016) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2238010..2238029) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2238016) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="upshifts" promotor_-35 complement(2238043..2238050) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2238098..2240311) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" /label="secDF CDS" gene complement(2238098..2240311) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /label="secDF gene" downshifts complement(2238103) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" promotor_-35 2239870..2239875 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2239889..2239908 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2239897 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2240350..2240646) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" /label="comN CDS" gene complement(2240350..2240646) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /label="comN gene" downshifts 2240557 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" /label="downshifts" S_feature complement(2240647..2240725) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2240687..2240692 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2240709..2240727 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2240711..2240730) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2240711 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="upshifts" upshifts complement(2240725) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="upshifts" S_feature complement(2240727..2241645) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2240745..2240748) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2240762..2242318 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" /label="spoVB CDS" gene 2240762..2242318 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /label="spoVB gene" promotor_-10 complement(2241631..2241649) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2241645) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="upshifts" promotor_-35 complement(2241661..2241669) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2242319..2243083 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2242322..2242978) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" /label="yrbG CDS" gene complement(2242322..2242978) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /label="yrbG gene" promotor_-10 complement(2242997..2243008) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2243009) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2243022..2243028) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2243061..2243066 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2243082..2243100 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2243085 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2243113..2243565 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" /label="yrzE CDS" gene 2243113..2243565 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /label="yrzE gene" downshifts 2243549 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2243604) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2243622..2243888) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" /label="yrbF CDS" gene complement(2243622..2243888) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /label="yrbF gene" CDS complement(2243925..2245070) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" /label="tgt CDS" gene complement(2243925..2245070) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /label="tgt gene" upshifts complement(2243977) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2244021) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2244023..2244042) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2244057..2244062) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2245097..2246125) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" /label="queA CDS" gene complement(2245097..2246125) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /label="queA gene" CDS complement(2246155..2246355) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" /label="yrzS CDS" gene complement(2246155..2246355) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /label="yrzS gene" CDS complement(2246348..2247352) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" /label="ruvB CDS" gene complement(2246348..2247352) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /label="ruvB gene" CDS complement(2247363..2247968) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" /label="ruvA CDS" gene complement(2247363..2247968) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /label="ruvA gene" promotor_-10 complement(2247987..2248006) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2248003) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2248005..2248106) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2248017..2248023) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2248107..2248619) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" /label="bofC CDS" gene complement(2248107..2248619) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /label="bofC gene" promotor_-10 complement(2248648..2248659) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2248663) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="upshifts" CDS complement(2248667..2249974) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" /label="csbX CDS" gene complement(2248667..2249974) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /label="csbX gene" promotor_-35 complement(2248674..2248680) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2249928) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2249998..2250016) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2250013) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="upshifts" promotor_-35 complement(2250031..2250037) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2250045..2251070) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" /label="yrbE CDS" gene complement(2250045..2251070) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /label="yrbE gene" promotor_-10 complement(2251107..2251126) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2251127) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="upshifts" promotor_-35 complement(2251141..2251148) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2251196..2251203 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2251217..2251236 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2251225 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2251257..2251262 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2251271 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2251278..2251296 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2251308..2251955 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" /label="yrzF CDS" gene 2251308..2251955 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /label="yrzF gene" S_feature complement(2251630..2251963) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2251934 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(2251965..2252162) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2252001..2252123) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" /label="hypothetical protein CDS" gene complement(2252001..2252123) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /label="gene" downshifts complement(2252008) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2252171) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2252172..2252189) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2252196..2252203) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2252208..2252498 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" /label="yrzH CDS" gene 2252208..2252498 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /label="yrzH gene" misc_feature 2252219..2252238 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2252219..2252366 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2252219 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="upshifts" CDS 2252505..2252645 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" /label="yrzT CDS" gene 2252505..2252645 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /label="yrzT gene" downshifts 2252634 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2252694..2252700 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2252708..2252808 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2252715..2252733 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2252716 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="upshifts" upshifts 2252768 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="upshifts" CDS 2252809..2254263 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" /label="alaP CDS" gene 2252809..2254263 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /label="alaP gene" downshifts 2254264 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2254304..2255026) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" /label="yrbC CDS" gene complement(2254304..2255026) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /label="yrbC gene" S_feature 2254309..2254730 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2254320) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2255049..2255068) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2255066) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2255082..2255089) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2255129..2255725) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" /label="sgpA CDS" gene complement(2255129..2255725) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /label="sgpA gene" downshifts complement(2255144) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2255768..2255779) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2255770) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2255772..2255836) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2255794..2255800) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2255873..2257036) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" /label="safA CDS" gene complement(2255873..2257036) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /label="safA gene" downshifts complement(2255881) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" /label="downshifts" S_feature complement(2257037..2257112) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2257088..2257106) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2257112) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2257122..2257127) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2257153..2258259) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" /label="nadA CDS" gene complement(2257153..2258259) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /label="nadA gene" promotor_-10 complement(2257835..2257853) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2257860) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2257869..2257874) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2258171 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2258172..2258175 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2258246..2259115) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" /label="nadC CDS" gene complement(2258246..2259115) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /label="nadC gene" downshifts 2258340 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2259069..2260664) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" /label="nadB CDS" gene complement(2259069..2260664) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /label="nadB gene" promotor_-35 2260692..2260699 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2260692..2260711) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2260713 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2260715..2260734 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2260716) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2260726..2260733) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2260767..2261954 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" /label="nifS CDS" gene 2260767..2261954 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /label="nifS gene" promotor_-10 complement(2260768..2260787) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2260786) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2260802..2260811) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2261669..2261674 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2261683 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2261685..2261704 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2261914..2262456 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" /label="niaR CDS" gene 2261914..2262456 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /label="niaR gene" downshifts 2262439 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2262481..2263338) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" /label="pheA CDS" gene complement(2262481..2263338) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /label="pheA gene" S_feature 2262484..2263193 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2262501) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2263355..2263798) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" /label="thrR CDS" gene complement(2263355..2263798) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /label="thrR gene" CDS complement(2263859..2265145) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" /label="obgE CDS" gene complement(2263859..2265145) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /label="obgE gene" CDS complement(2265179..2265757) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" /label="spo0B CDS" gene complement(2265179..2265757) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /label="spo0B gene" S_feature complement(2265758..2265823) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2265808..2265827) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2265823) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2265825..2266042) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2265835..2265957 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" /label="hypothetical protein CDS" gene 2265835..2265957 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /label="gene" promotor_-35 complement(2265841..2265848) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2266078..2266362) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" /label="rpmA CDS" gene complement(2266078..2266362) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /label="rpmA gene" downshifts complement(2266087) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" CDS complement(2266375..2266713) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" /label="rppA CDS" gene complement(2266375..2266713) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /label="rppA gene" CDS complement(2266716..2267024) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" /label="rplU CDS" gene complement(2266716..2267024) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /label="rplU gene" misc_RNA complement(2267038..2267113) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" /label="ldlU RNA" gene complement(2267038..2267113) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /label="ldlU gene" promotor_-10 complement(2267125..2267144) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2267145) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2267158..2267165) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2267171..2268037) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" /label="spoIVFB CDS" gene complement(2267171..2268037) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /label="spoIVFB gene" CDS complement(2268030..2268824) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" /label="spoIVFA CDS" gene complement(2268030..2268824) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /label="spoIVFA gene" downshifts 2268827 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" /label="downshifts" promotor_no_box 2268833..2268933 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2268848..2268866) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2268859) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="upshifts" promotor_-35 complement(2268882..2268887) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2268893 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2268936 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(2268971) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2268974..2269780) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" /label="minD CDS" gene complement(2268974..2269780) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /label="minD gene" CDS complement(2269782..2270462) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" /label="minC CDS" gene complement(2269782..2270462) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /label="minC gene" CDS complement(2270515..2271033) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" /label="mreD CDS" gene complement(2270515..2271033) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /label="mreD gene" CDS complement(2271030..2271902) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" /label="mreC CDS" gene complement(2271030..2271902) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /label="mreC gene" CDS complement(2271933..2272946) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" /label="mreB CDS" gene complement(2271933..2272946) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /label="mreB gene" upshifts complement(2272987) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2272999..2273017) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2273038..2273733) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" /label="ysxA CDS" gene complement(2273038..2273733) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /label="ysxA gene" CDS complement(2273770..2274339) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" /label="maf CDS" gene complement(2273770..2274339) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /label="maf gene" promotor_-10 complement(2274191..2274206) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2274200) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2274219..2274228) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2274378..2274397) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2274394) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2274411..2274417) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2274490) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2274492..2275490) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" /label="spoIIB CDS" gene complement(2274492..2275490) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /label="spoIIB gene" promotor_-10 complement(2275537..2275556) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2275545) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2275568..2275575) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2275613) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS complement(2275624..2276370) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" /label="comC CDS" gene complement(2275624..2276370) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /label="comC gene" promotor_-10 complement(2276398..2276417) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2276405) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2276432..2276439) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2276510..2277802) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" /label="folC CDS" gene complement(2276510..2277802) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /label="folC gene" downshifts complement(2276515) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2277803..2277861) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2277862..2280504) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" /label="valS CDS" gene complement(2277862..2280504) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /label="valS gene" S_feature complement(2280505..2280563) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2280564..2280786) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboV RNA" gene complement(2280564..2280786) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /label="tboV gene" downshifts complement(2280607) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2280815..2280834) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2280827) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2280829..2280937) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2280849..2280854) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2280891..2280900 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2280913..2280932 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2280914 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2280930..2280944) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2280937) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2280952..2280956) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2280952..2281143 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" /label="yszA CDS" gene 2280952..2281143 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /label="yszA gene" CDS complement(2281162..2282187) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" /label="cotN CDS" gene complement(2281162..2282187) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /label="cotN gene" downshifts complement(2281192) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" /label="downshifts" CDS complement(2282220..2283947) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" /label="spoVID CDS" gene complement(2282220..2283947) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /label="spoVID gene" promotor_-35 2283549..2283552 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2283568..2283587 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2283574 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2283943..2283947 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2283956..2283970 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2283970 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2283985..2284003) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2284001) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="upshifts" promotor_-35 complement(2284019..2284024) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2284078..2285370) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" /label="hemL CDS" gene complement(2284078..2285370) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /label="hemL gene" downshifts complement(2284095) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2285400..2286374) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" /label="hemB CDS" gene complement(2285400..2286374) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /label="hemB gene" CDS complement(2286371..2287159) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" /label="hemD CDS" gene complement(2286371..2287159) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /label="hemD gene" CDS complement(2287149..2288093) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" /label="hemC CDS" gene complement(2287149..2288093) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /label="hemC gene" CDS complement(2288126..2288956) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" /label="hemX CDS" gene complement(2288126..2288956) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /label="hemX gene" CDS complement(2288964..2290331) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" /label="hemA CDS" gene complement(2288964..2290331) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /label="hemA gene" misc_feature complement(2290395..2290414) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2290401) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2290403..2290492) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2290452..2290471 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2290460 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2290489..2290508) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2290492) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2290494..2290910) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2290519..2290527) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2290561..2291058 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" /label="ysxD CDS" gene 2290561..2291058 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /label="ysxD gene" promotor_-10 complement(2290894..2290912) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2290910) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2290912..2291042) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2290928..2290934) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2291022..2291033) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2291042) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="upshifts" promotor_-35 complement(2291048..2291054) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2291080..2291667) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" /label="engB CDS" gene complement(2291080..2291667) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /label="engB gene" downshifts complement(2291108) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2291664..2293988) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" /label="lonA CDS" gene complement(2291664..2293988) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /label="lonA gene" S_feature complement(2293989..2294100) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2294085..2294104) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2294100) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2294118..2294125) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2294169..2295827) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" /label="lonB CDS" gene complement(2294169..2295827) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /label="lonB gene" downshifts complement(2294188) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2295871..2295889) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2295882) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2295905..2295910) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2295979..2297241) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" /label="clpX CDS" gene complement(2295979..2297241) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /label="clpX gene" downshifts complement(2295989) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2297242..2297331) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2297319..2297338) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2297331) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2297333..2297464) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2297350..2297357) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2297509) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" CDS complement(2297513..2298787) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" /label="tig CDS" gene complement(2297513..2298787) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /label="tig gene" S_feature complement(2298788..2298977) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2298964..2298983) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2298977) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2298998..2299002) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2299015..2300019) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" /label="ysoA CDS" gene complement(2299015..2300019) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /label="ysoA gene" promotor_-10 complement(2300044..2300063) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2300062) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2300075..2300082) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2300138..2300737) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" /label="leuD CDS" gene complement(2300138..2300737) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /label="leuD gene" downshifts complement(2300159) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" /label="downshifts" CDS complement(2300750..2302168) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" /label="leuC CDS" gene complement(2300750..2302168) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /label="leuC gene" promotor_-35 2302057..2302061 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2302076..2302080 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2302076 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2302218..2303315) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" /label="leuB CDS" gene complement(2302218..2303315) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /label="leuB gene" CDS complement(2303336..2304892) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" /label="leuA CDS" gene complement(2303336..2304892) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /label="leuA gene" promotor_-35 2303732..2303735 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2303748..2306189 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2303748 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2303750..2303769 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2304879..2305907) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" /label="ilvC CDS" gene complement(2304879..2305907) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /label="ilvC gene" CDS complement(2305931..2306449) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" /label="ilvH CDS" gene complement(2305931..2306449) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /label="ilvH gene" promotor_-35 2306170..2306173 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2306189..2306193 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2306191 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2306446..2308170) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" /label="ilvB CDS" gene complement(2306446..2308170) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /label="ilvB gene" S_feature complement(2308171..2308291) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2308292..2308538) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboILV RNA" gene complement(2308292..2308538) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /label="tboILV gene" downshifts complement(2308335) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" /label="downshifts" S_feature complement(2308539..2308665) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2308647..2308666) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2308665) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="upshifts" S_feature complement(2308667..2308797) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2308681..2308688) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2308792..2308811) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2308801) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2308825..2308828) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2308923..2308932 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2308946..2308965 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2308948 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="upshifts" CDS 2308986..2309321 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" /label="cotQ CDS" gene 2308986..2309321 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /label="cotQ gene" downshifts 2309315 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-35 2309402..2309409 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2309423..2309442 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2309425..2309489 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2309425 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="upshifts" CDS 2309490..2309945 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" /label="ysnE CDS" gene 2309490..2309945 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /label="ysnE gene" promotor_-35 2310053..2310059 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2310073..2310091 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2310080 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="upshifts" CDS 2310129..2310950 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" /label="ysnF CDS" gene 2310129..2310950 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /label="ysnF gene" downshifts 2310943 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts 2311007 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" /label="downshifts" tRNA complement(2311014..2311087) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg2 tRNA" gene complement(2311014..2311087) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /label="trnSL-Arg2 gene" downshifts complement(2311048) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2311124..2311143) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2311127) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2311157..2311164) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2311218..2311727) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" /label="ysnB CDS" gene complement(2311218..2311727) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /label="ysnB gene" downshifts complement(2311235) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" /label="downshifts" CDS complement(2311743..2312339) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" /label="rdgB CDS" gene complement(2311743..2312339) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /label="rdgB gene" CDS complement(2312352..2313089) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" /label="rph CDS" gene complement(2312352..2313089) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /label="rph gene" promotor_-10 complement(2313171..2313190) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2313187) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2313200..2314300) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" /label="gerM CDS" gene complement(2313200..2314300) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /label="gerM gene" promotor_-35 complement(2313205..2313210) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2313217) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2314323..2314341) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2314339) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2314356..2314361) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2314415..2315233) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" /label="rcmE CDS" gene complement(2314415..2315233) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /label="rcmE gene" downshifts complement(2314427) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2315241..2315681) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" /label="ysmB CDS" gene complement(2315241..2315681) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /label="ysmB gene" promotor_-10 complement(2315724..2315743) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2315733) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2315735..2315877) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2315759..2315763) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2315922) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" CDS complement(2315925..2316149) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" /label="gerE CDS" gene complement(2315925..2316149) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /label="gerE gene" upshifts 2316198 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2316200..2316218 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2316207..2316226) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2316227) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2316240..2316249) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2316265..2316708) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" /label="ysmA CDS" gene complement(2316265..2316708) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /label="ysmA gene" CDS complement(2316769..2317530) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" /label="sdhB CDS" gene complement(2316769..2317530) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /label="sdhB gene" downshifts complement(2316777) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2317533..2319293) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" /label="sdhA CDS" gene complement(2317533..2319293) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /label="sdhA gene" CDS complement(2319327..2319935) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" /label="sdhC CDS" gene complement(2319327..2319935) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /label="sdhC gene" promotor_-35 2319705..2319712 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2319725..2319744 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2319727 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2319936..2320031) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2320021..2320040) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2320031) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="upshifts" S_feature complement(2320033..2320654) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2320055..2320062) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2320170..2320174 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2320184..2320284 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2320191..2320210 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2320200 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" CDS 2320228..2320674 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" /label="yslB CDS" gene 2320228..2320674 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /label="yslB gene" upshifts 2320244 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" downshifts 2320662 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2320700) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" /label="downshifts" CDS complement(2320718..2321944) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" /label="lysCA CDS" CDS complement(2320718..2321209) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" /label="lysCB CDS" gene complement(2320718..2321944) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /label="lysCA gene" gene complement(2320718..2321209) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /label="lysCB gene" downshifts complement(2322058) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" /label="downshifts" misc_RNA complement(2322070..2322249) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" /label="kswC RNA" gene complement(2322070..2322249) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /label="kswC gene" downshifts complement(2322102) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2322274..2322293) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2322281) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="upshifts" promotor_-35 complement(2322306..2322313) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2322314..2324086) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" /label="uvrC CDS" gene complement(2322314..2324086) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /label="uvrC gene" promotor_-10 complement(2324113..2324132) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2324127) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="upshifts" promotor_-35 complement(2324146..2324153) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2324216) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" /label="downshifts" CDS complement(2324222..2324536) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" /label="trxA CDS" gene complement(2324222..2324536) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /label="trxA gene" promotor_-10 complement(2324562..2324581) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2324576) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2324578..2324787) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2324597..2324599) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2324681..2324791) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" /label="CDS C-terminal fragment" gene complement(2324681..2324791) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo /label="gene" promotor_-10 complement(2324777..2324795) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2324787) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="upshifts" promotor_-35 complement(2324810..2324816) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2324859..2326346) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" /label="abfB CDS" gene complement(2324859..2326346) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /label="abfB gene" S_feature complement(2326347..2326459) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2326440..2326459) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2326459) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="upshifts" promotor_-35 complement(2326474..2326481) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2326563..2327540) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" /label="etfA CDS" gene complement(2326563..2327540) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /label="etfA gene" downshifts complement(2326571) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2327576..2328349) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" /label="etfB CDS" gene complement(2327576..2328349) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /label="etfB gene" CDS complement(2328364..2329140) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" /label="fadB CDS" gene complement(2328364..2329140) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /label="fadB gene" downshifts 2328429 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" /label="downshifts" CDS complement(2329155..2329739) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" /label="fadR CDS" gene complement(2329155..2329739) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /label="fadR gene" promotor_-10 complement(2329781..2329800) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2329781) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2329813..2329820) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2329844..2331526) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" /label="lcfA CDS" gene complement(2329844..2331526) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /label="lcfA gene" misc_feature complement(2331555..2331574) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2331563) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2331651) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2331715..2332119) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" /label="yshE CDS" gene complement(2331715..2332119) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /label="yshE gene" downshifts complement(2331717) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2332134..2334491) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" /label="mutSB CDS" gene complement(2332134..2334491) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /label="mutSB gene" CDS complement(2334512..2336224) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" /label="polX CDS" gene complement(2334512..2336224) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /label="polX gene" S_feature complement(2336225..2336297) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2336298..2336831) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" /label="yshB CDS" gene complement(2336298..2336831) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /label="yshB gene" CDS complement(2336838..2337095) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" /label="zapA CDS" gene complement(2336838..2337095) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /label="zapA gene" promotor_-10 complement(2337122..2337141) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2337138) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2337153..2337160) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2337178..2337197 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2337185 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="upshifts" CDS 2337229..2338170 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" /label="rnhC CDS" gene 2337229..2338170 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /label="rnhC gene" promotor_-10 complement(2337902..2337921) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2337917) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2337935..2337942) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2338153 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2338185) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2338206..2340620) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" /label="pheT CDS" gene complement(2338206..2340620) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /label="pheT gene" downshifts complement(2338229) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2340636..2341670) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" /label="pheS CDS" gene complement(2340636..2341670) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /label="pheS gene" S_feature complement(2341671..2341991) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2341752..2341958 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" /label="hypothetical protein CDS" gene 2341752..2341958 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /label="gene" S_feature 2341981..2342245 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2341981 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2341986..2342005) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2341988..2342002 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2341991) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2342020..2342023) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2342025..2342771) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" /label="rlmBB CDS" gene complement(2342025..2342771) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /label="rlmBB gene" promotor_-10 complement(2342798..2342817) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2342804..2342810 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2342811) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="upshifts" promotor_-10 2342824..2342835 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2342831..2342837) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2342838 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2342890..2343105 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" /label="sspI CDS" gene 2342890..2343105 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /label="sspI gene" S_feature complement(2343087..2344499) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2343116..2343123 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2343139..2343158 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2343147 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2343174..2344280 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" /label="ysfB CDS" gene 2343174..2344280 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /label="ysfB gene" promotor_-35 2344316..2344319 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2344335..2344354 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2344339 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="upshifts" CDS 2344383..2345795 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" /label="glcD CDS" gene 2344383..2345795 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /label="glcD gene" promotor_-10 complement(2344485..2344504) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2344499) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2344517..2344526) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2345792..2347126 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" /label="glcF CDS" gene 2345792..2347126 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /label="glcF gene" Polymorphism join(2346825,2346827) /Source="geneious" /ID="SNP_BsDelta6_2935628_2935628" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=1035 /Change="C -> T" /Codon_Change="CTC -> CTT" /Coverage=142 /locus_tag="BSU_28690" /Protein_Effect="None" /Reference_Frequency="1.4%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=140 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2347124 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" downshifts complement(2347163) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2347165..2347407) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" /label="ysfE CDS" gene complement(2347165..2347407) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /label="ysfE gene" S_feature complement(2347408..2347579) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2347467..2347637) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" /label="hypothetical protein CDS" gene complement(2347467..2347637) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /label="gene" CDS complement(2347580..2349376) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" /label="cstA CDS" gene complement(2347580..2349376) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /label="cstA gene" promotor_-10 complement(2347682..2347700) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2347700) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2347712..2347720) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2349373 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2349401..2349420) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2349411) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2349435..2349441) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2349471..2349527) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2349495) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2349528..2351030) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" /label="abfA CDS" gene complement(2349528..2351030) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /label="abfA gene" downshifts complement(2350901) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(2351005..2351105) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2351045) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2351049..2351894) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" /label="araQ CDS" gene complement(2351049..2351894) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /label="araQ gene" CDS complement(2351895..2352836) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" /label="araP CDS" gene complement(2351895..2352836) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /label="araP gene" CDS complement(2352872..2354173) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" /label="araN CDS" gene complement(2352872..2354173) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /label="araN gene" CDS complement(2354204..2355388) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" /label="egsA CDS" gene complement(2354204..2355388) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /label="egsA gene" CDS complement(2355385..2356203) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" /label="araL CDS" gene complement(2355385..2356203) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /label="araL gene" CDS complement(2356181..2356870) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" /label="araD CDS" gene complement(2356181..2356870) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /label="araD gene" CDS complement(2356887..2358569) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" /label="araB CDS" gene complement(2356887..2358569) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /label="araB gene" CDS complement(2358583..2360073) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" /label="araA CDS" gene complement(2358583..2360073) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /label="araA gene" promotor_-10 complement(2360166..2360185) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2360173) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2360175..2360250) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2360200..2360207) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2360251..2361222) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" /label="abnA CDS" gene complement(2360251..2361222) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /label="abnA gene" S_feature complement(2361223..2361351) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2361336..2361355) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2361351) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2361370..2361373) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2361419..2362504) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" /label="frvX CDS" gene complement(2361419..2362504) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /label="frvX gene" downshifts complement(2361433) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2362530..2362549) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2362553) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2362564..2362571) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2362622..2362631 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2362637 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2362643..2362658 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2362688..2363080 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" /label="ysdB CDS" gene 2362688..2363080 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /label="ysdB gene" downshifts 2363051 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" /label="downshifts" S_feature 2363096..2363402 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2363096..2363365) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" /label="ysdA CDS" gene complement(2363096..2363365) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /label="ysdA gene" downshifts complement(2363112) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" downshifts complement(2363281) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2363359 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" CDS complement(2363422..2363781) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" /label="rplT CDS" gene complement(2363422..2363781) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /label="rplT gene" downshifts complement(2363435) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(2363813..2364013) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" /label="rpmI CDS" gene complement(2363813..2364013) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /label="rpmI gene" CDS complement(2364026..2364547) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" /label="infC CDS" gene complement(2364026..2364547) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /label="infC gene" misc_RNA complement(2364609..2364748) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" /label="mRNA L20 leader attenuator sequence" gene complement(2364609..2364748) /locus_tag="BSU_misc_RNA_47" /label="gene" promotor_-10 complement(2364745..2364764) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2364755) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2364757..2364821) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2364778..2364785) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2364803..2364822) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2364821) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2364838..2364842) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2364940..2364947 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2364961..2364979 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2364961 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="upshifts" CDS 2364993..2365658 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" /label="yscB CDS" gene 2364993..2365658 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /label="yscB gene" downshifts 2365636 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2365690..2366385) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" /label="pftB CDS" gene complement(2365690..2366385) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /label="pftB gene" downshifts complement(2365712) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2365756) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(2366407..2366847) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" /label="pftA CDS" gene complement(2366407..2366847) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /label="pftA gene" promotor_-10 complement(2366869..2366888) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2366888) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2366904..2366907) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2366981..2367706) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" /label="lytT CDS" gene complement(2366981..2367706) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /label="lytT gene" downshifts complement(2367010) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" /label="downshifts" CDS complement(2367684..2369465) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" /label="lytS CDS" gene complement(2367684..2369465) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /label="lytS gene" promotor_-35 2369549..2369552 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2369561..2369580) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2369566) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2369567..2369586 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2369574 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2369632..2370414 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" /label="ysaA CDS" gene 2369632..2370414 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /label="ysaA gene" downshifts 2370398 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" downshifts complement(2370448) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2370455..2372386) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" /label="thrS CDS" gene complement(2370455..2372386) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /label="thrS gene" misc_RNA complement(2372430..2372677) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboT RNA" gene complement(2372430..2372677) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /label="tboT gene" promotor_-10 complement(2372433..2372442) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2372433) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2372488) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2372688..2372707) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2372701) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2372703..2372783) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2372723..2372727) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2372784..2373629) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" /label="ytxC CDS" gene complement(2372784..2373629) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /label="ytxC gene" promotor_-10 complement(2373649..2373667) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2373655) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2373683..2373688) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2373708..2374349) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" /label="ytxB CDS" gene complement(2373708..2374349) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /label="ytxB gene" CDS complement(2374383..2375318) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" /label="dnaI CDS" gene complement(2374383..2375318) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /label="dnaI gene" CDS complement(2375346..2376764) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" /label="dnaB CDS" gene complement(2375346..2376764) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /label="dnaB gene" promotor_-10 complement(2376793..2376812) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2376801) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2376827..2376830) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2376879..2377337) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" /label="nrdR CDS" gene complement(2376879..2377337) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /label="nrdR gene" downshifts complement(2376898) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2377338..2377485) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2377476..2377495) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2377485) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="upshifts" S_feature complement(2377487..2377565) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2377510..2377513) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2377610) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" /label="downshifts" CDS complement(2377611..2377991) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" /label="speD CDS" gene complement(2377611..2377991) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /label="speD gene" S_feature complement(2377992..2378146) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2378126..2378145) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2378133 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2378134..2378153 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2378146) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2378160..2378166) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2378224..2378235) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2378230..2379252) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" /label="gapB CDS" gene complement(2378230..2379252) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /label="gapB gene" upshifts complement(2378231) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2378250..2378256) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2379296..2379315) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2379327) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2379328..2379335) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2379458..2379838) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" /label="ytcD CDS" gene complement(2379458..2379838) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /label="ytcD gene" downshifts complement(2379482) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(2379839..2379969) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2379894..2379898 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2379914..2379933 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2379915..2380021 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2379915 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2379959..2379978) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2379969) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2379993..2380000) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2380022..2381212 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" /label="ytbD CDS" gene 2380022..2381212 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /label="ytbD gene" promotor_-10 complement(2380844..2380862) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2380860) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2380878..2380883) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2381236..2382078 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" /label="ytbE CDS" gene 2381236..2382078 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /label="ytbE gene" promotor_-35 2381851..2381856 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2381872..2381890 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2381873 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2382071 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2382111) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2382120..2382713) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" /label="coaE CDS" gene complement(2382120..2382713) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /label="coaE gene" CDS complement(2382729..2383361) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" /label="spcF CDS" gene complement(2382729..2383361) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /label="spcF gene" S_feature complement(2383362..2383526) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2383527..2384357) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" /label="mutM CDS" gene complement(2383527..2384357) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /label="mutM gene" CDS complement(2384380..2387022) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" /label="polA CDS" gene complement(2384380..2387022) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /label="polA gene" promotor_-10 complement(2387077..2387096) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2387086) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2387110..2387117) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2387146..2387265) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2387189) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2387266..2389005) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" /label="phoR CDS" gene complement(2387266..2389005) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /label="phoR gene" CDS complement(2388998..2389720) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" /label="phoP CDS" gene complement(2388998..2389720) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /label="phoP gene" promotor_-10 complement(2389788..2389807) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2389798) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2389800..2389900) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2389821..2389827) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2389932..2390870) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" /label="mdh CDS" gene complement(2389932..2390870) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /label="mdh gene" downshifts complement(2389945) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2390914..2392185) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" /label="icd CDS" gene complement(2390914..2392185) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /label="icd gene" misc_feature complement(2391970..2391989) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2391982) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2392186..2392268) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2392268) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="upshifts" S_feature complement(2392270..2392348) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2392270..2392289) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2392305..2392309) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2392349..2393467) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" /label="citZ CDS" gene complement(2392349..2393467) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /label="citZ gene" downshifts 2392962 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" misc_feature 2393309..2393312 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2393317 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2393446 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2393468..2393674) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2393642..2393654 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2393653 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2393660..2393679) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2393674) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2393694..2393698) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2393794) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" /label="downshifts" CDS complement(2393801..2394265) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" /label="ytwI CDS" gene complement(2393801..2394265) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /label="ytwI gene" promotor_-10 complement(2394278..2394297) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2394292) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2394294..2395479) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2394294..2394299 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2394310..2394318) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2394314..2394332 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2394320 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="upshifts" CDS 2394362..2395477 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" /label="ytvI CDS" gene 2394362..2395477 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /label="ytvI gene" downshifts 2395448 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2395510..2395893) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" /label="ytzA CDS" gene complement(2395510..2395893) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /label="ytzA gene" downshifts complement(2395524) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2395894..2395985) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2395986..2397743) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" /label="pyk CDS" gene complement(2395986..2397743) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /label="pyk gene" CDS complement(2397786..2398745) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" /label="pfkA CDS" gene complement(2397786..2398745) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /label="pfkA gene" S_feature complement(2398746..2398847) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2398836..2398855) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2398847) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2398871..2398875) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2398929..2399906) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" /label="accA CDS" gene complement(2398929..2399906) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /label="accA gene" downshifts complement(2398956) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2399891..2400763) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" /label="accD CDS" gene complement(2399891..2400763) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /label="accD gene" promotor_-35 2400725..2400730 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2400746..2400764 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2400750..2401924 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2400750 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2400764..2400847) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2400836..2400855) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2400847) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2400849..2401001) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2400871..2400875) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2401003..2401097) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2401046) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" /label="downshifts" CDS complement(2401098..2402330) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" /label="maeB CDS" gene complement(2401098..2402330) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /label="maeB gene" S_feature complement(2402331..2402447) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2402435..2402454) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2402447) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" CDS complement(2402467..2405814) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" /label="dnaEC CDS" gene complement(2402467..2405814) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /label="dnaEC gene" promotor_-35 complement(2402468..2402475) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2403479..2403488 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2403500..2403515 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2403500 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2403688..2403707) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2403707) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2403721..2403728) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2405845..2405864) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2405863) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" promotor_-35 complement(2405878..2405885) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2405903..2405908 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2405920 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="upshifts" promotor_-10 2405924..2405942 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2405954..2406295 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" /label="ytrH CDS" gene 2405954..2406295 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /label="ytrH gene" CDS 2406292..2406795 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" /label="ytrI CDS" gene 2406292..2406795 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /label="ytrI gene" promotor_-35 2406828..2406831 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2406846..2406865 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2406846 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" CDS 2406897..2407088 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" /label="ytzJ CDS" gene 2406897..2407088 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /label="ytzJ gene" downshifts complement(2406898) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" /label="downshifts" downshifts 2407064 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2407106..2408047) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" /label="nrnA CDS" gene complement(2407106..2408047) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /label="nrnA gene" S_feature 2407109..2407480 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2407141) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2407449..2407458 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2407472..2407491 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2407482..2407876 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2407482 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2407838..2407844 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2407860..2407879 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2407878..2408177 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2407878 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2408066..2408085) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2408082) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2408084..2408498) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2408100..2408103) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2408178..2408480 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" /label="ytpI CDS" gene 2408178..2408480 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /label="ytpI gene" S_feature 2408481..2410276 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2408499..2409818) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" /label="ytoI CDS" gene complement(2408499..2409818) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /label="ytoI gene" promotor_-10 complement(2409844..2409863) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2409865) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2409878..2409883) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2409994..2410896) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" /label="ytnM CDS" gene complement(2409994..2410896) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /label="ytnM gene" CDS complement(2410915..2412165) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" /label="sndA CDS" gene complement(2410915..2412165) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /label="sndA gene" CDS complement(2412183..2412875) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" /label="ribR CDS" gene complement(2412183..2412875) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /label="ribR gene" CDS complement(2412922..2414250) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" /label="cmoJ CDS" gene complement(2412922..2414250) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /label="cmoJ gene" CDS complement(2414247..2414528) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" /label="cmoI CDS" gene complement(2414247..2414528) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /label="cmoI gene" CDS complement(2414543..2415547) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" /label="cmoO CDS" gene complement(2414543..2415547) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /label="cmoO gene" CDS complement(2415544..2416323) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" /label="tcyN CDS" gene complement(2415544..2416323) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /label="tcyN gene" CDS complement(2416320..2417027) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" /label="tcyM CDS" gene complement(2416320..2417027) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /label="tcyM gene" CDS complement(2417057..2417776) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" /label="tcyL CDS" gene complement(2417057..2417776) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /label="tcyL gene" promotor_-35 2417602..2417609 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2417624..2417643 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2417624 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2417798..2418610) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" /label="tcyK CDS" gene complement(2417798..2418610) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /label="tcyK gene" CDS complement(2418624..2419433) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" /label="tcyJ CDS" gene complement(2418624..2419433) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /label="tcyJ gene" CDS complement(2419447..2419983) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" /label="snaA CDS" gene complement(2419447..2419983) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /label="snaA gene" promotor_-35 2420020..2420027 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2420038..2420057) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2420041..2420060 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2420044..2420135 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2420044 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2420054) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2420071..2420078) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2420136..2421062 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" /label="ascR CDS" gene 2420136..2421062 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /label="ascR gene" S_feature complement(2420538..2421067) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2421112) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" /label="downshifts" CDS complement(2421113..2421796) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" /label="ytkL CDS" gene complement(2421113..2421796) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /label="ytkL gene" S_feature complement(2421797..2421858) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2421859..2422626) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" /label="ytkK CDS" gene complement(2421859..2422626) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /label="ytkK gene" promotor_-10 complement(2422671..2422690) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2422693) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2422706..2422708) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2422753..2422989) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" /label="ytzD CDS" gene complement(2422753..2422989) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /label="ytzD gene" downshifts 2422838 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" /label="downshifts" downshifts complement(2422858) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" /label="downshifts" CDS complement(2422949..2424334) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" /label="argH CDS" gene complement(2422949..2424334) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /label="argH gene" CDS complement(2424331..2425542) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" /label="argG CDS" gene complement(2424331..2425542) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /label="argG gene" S_feature complement(2425543..2425620) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2425613..2425632) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2425619) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2425647..2425654) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2425712..2426224) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" /label="moaB CDS" gene complement(2425712..2426224) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /label="moaB gene" downshifts complement(2425730) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2426250..2426269) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2426258) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2426283..2426290) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2426309..2427496) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" /label="ackA CDS" gene complement(2426309..2427496) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /label="ackA gene" downshifts complement(2426324) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" /label="downshifts" S_feature complement(2427497..2427601) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2427586..2427605) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2427601) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2427603..2427732) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2427621..2427625) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2427669..2427872) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" /label="hypothetical protein CDS" gene complement(2427669..2427872) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /label="gene" promotor_-10 complement(2427730..2427741) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2427732) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2427756..2427762) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2427844..2428833) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" /label="ytxK CDS" gene complement(2427844..2428833) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /label="ytxK gene" downshifts complement(2427862) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2428894..2429397) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" /label="tpx CDS" gene complement(2428894..2429397) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /label="tpx gene" downshifts complement(2428900) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" /label="downshifts" promotor_no_box 2429114..2429214 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2429174 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2429393 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2429420..2429439) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2429436) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2429453..2429460) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2429507..2429962) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" /label="gerW CDS" gene complement(2429507..2429962) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /label="gerW gene" downshifts complement(2429535) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" CDS complement(2429976..2430656) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" /label="ytfI CDS" gene complement(2429976..2430656) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /label="ytfI gene" upshifts complement(2430068) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="upshifts" promotor_-10 complement(2430075..2430086) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2430101..2430107) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2430394) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2430669..2430687) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2430683) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="upshifts" promotor_-35 complement(2430702..2430707) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2430731..2431225) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" /label="yteJ CDS" gene complement(2430731..2431225) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /label="yteJ gene" downshifts complement(2430746) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2431238..2432245) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" /label="sppA CDS" gene complement(2431238..2432245) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /label="sppA gene" promotor_-10 complement(2432269..2432284) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2432286) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2432288..2432367) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2432296..2432305) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2432345..2432364 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2432355 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2432360..2432379) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2432364..2432430 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2432367) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2432395..2432399) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2432431..2433234 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" /label="ppnKB CDS" gene 2432431..2433234 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /label="ppnKB gene" downshifts 2433164 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" /label="downshifts" downshifts 2433222 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2433266..2434855) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" /label="ytcJ CDS" gene complement(2433266..2434855) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /label="ytcJ gene" downshifts complement(2433275) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2434875..2436464) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" /label="ytcI CDS" gene complement(2434875..2436464) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /label="ytcI gene" promotor_-10 complement(2436510..2436527) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2436515) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2436543..2436549) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2436642) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2436643..2436852) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" /label="sspA CDS" gene complement(2436643..2436852) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /label="sspA gene" promotor_-35 2436848..2436852 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2436852 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2436861..2436875 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2436873..2436884) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2436884) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2436899..2436905) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2436946..2438151) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" /label="trmG CDS" gene complement(2436946..2438151) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /label="trmG gene" CDS complement(2438155..2439300) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" /label="iscSB CDS" gene complement(2438155..2439300) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /label="iscSB gene" S_feature complement(2439301..2440444) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2439387..2439394 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2439405..2439494 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2439405 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2439407..2439426 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2439495..2440832 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" /label="braB CDS" gene 2439495..2440832 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /label="braB gene" promotor_-10 complement(2440430..2440449) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2440444) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2440464..2440471) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2440808 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2440927..2442615) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" /label="ezrA CDS" gene complement(2440927..2442615) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /label="ezrA gene" downshifts complement(2440928) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2442616..2442721) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2442698..2442706 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2442709..2442728) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2442717..2442736 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2442721) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" upshifts 2442721 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2442722..2442811 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2442723..2443282) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2442744..2442746) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2442812..2443618 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" /label="hisK CDS" gene 2442812..2443618 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /label="hisK gene" promotor_-10 complement(2443286..2443305) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2443299) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2443317..2443324) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2443568..2443614) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2443590) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2443615..2444238) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" /label="refZ CDS" gene complement(2443615..2444238) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /label="refZ gene" S_feature 2443619..2443961 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2443939..2443946 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2443961..2443980 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2443963..2444106 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2443963 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2444078..2444082 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2444098..2444117 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2444108..2444238 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2444108 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2444240..2444364 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2444240 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2444254..2444272) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2444256..2444275 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2444272) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2444283..2444291) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2444365..2444856 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" /label="msrC CDS" gene 2444365..2444856 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /label="msrC gene" downshifts 2444835 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2444894..2446633) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" /label="dgcP CDS" gene complement(2444894..2446633) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /label="dgcP gene" downshifts complement(2444912) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" promotor_-35 2446107..2446114 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2446128..2446146 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2446131 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="upshifts" S_feature 2446133..2446728 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2446663..2446682) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2446671) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2446673..2447506) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2446709..2446716 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2446730..2446927 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2446730..2446749 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2446730 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2446787..2446919 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" /label="ldsD RNA" gene 2446787..2446919 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /label="ldsD gene" CDS 2446928..2447530 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" /label="rpsD CDS" gene 2446928..2447530 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /label="rpsD gene" downshifts 2447453 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(2447508..2447727) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2447516 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" /label="downshifts" downshifts complement(2447551) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2447563 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2447608..2447781 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2447723..2447741) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2447735) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="upshifts" downshifts 2447739 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2447756..2447762) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2447801..2449069) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" /label="tyrS CDS" gene complement(2447801..2449069) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /label="tyrS gene" downshifts complement(2447827) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" misc_RNA complement(2449093..2449366) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" /label="tboY RNA" gene complement(2449093..2449366) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /label="tboY gene" S_feature complement(2449114..2449257) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2449157) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2449364..2449383) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2449376) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2449396..2449403) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2449411..2451129) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" /label="acsA CDS" gene complement(2449411..2451129) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /label="acsA gene" promotor_-35 2451143..2451150 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2451157..2451176) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2451165..2451184 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2451171 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2451180) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2451190..2451196) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2451213..2451220 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2451234..2451253 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2451237 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2451290..2451922 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" /label="acuA CDS" gene 2451290..2451922 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /label="acuA gene" promotor_-35 2451495..2451503 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2451517..2451536 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2451523 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2451949..2452593 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" /label="acuB CDS" gene 2451949..2452593 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /label="acuB gene" CDS 2452590..2453753 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" /label="acuC CDS" gene 2452590..2453753 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /label="acuC gene" downshifts 2453744 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2453764..2454492) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" /label="motS CDS" gene complement(2453764..2454492) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /label="motS gene" downshifts complement(2453800) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2454482..2455300) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" /label="motP CDS" gene complement(2454482..2455300) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /label="motP gene" CDS complement(2455363..2456367) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" /label="ccpA CDS" gene complement(2455363..2456367) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /label="ccpA gene" downshifts complement(2455380) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(2456402..2456421) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2456417) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2456419..2456527) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2456527..2456546) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2456527) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2456529..2456594) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2456560..2456566) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2456640) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2456643..2457719) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" /label="aroX CDS" gene complement(2456643..2457719) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /label="aroX gene" promotor_-10 complement(2457760..2457779) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2457780) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="upshifts" S_feature complement(2457782..2457882) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2457794..2457801) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2457816 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2457870..2457889) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2457882) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2457903..2457909) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2457955..2458281) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" /label="brxJ CDS" gene complement(2457955..2458281) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /label="brxJ gene" downshifts complement(2457964) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2458305..2458760) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" /label="ytxH CDS" gene complement(2458305..2458760) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /label="ytxH gene" CDS complement(2458791..2459213) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" /label="ytxG CDS" gene complement(2458791..2459213) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /label="ytxG gene" promotor_-10 complement(2459234..2459252) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2459247) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2459266..2459272) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2459286..2459304) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2459295) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="upshifts" promotor_-35 complement(2459315..2459323) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2459375..2460673) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" /label="murC CDS" gene complement(2459375..2460673) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /label="murC gene" downshifts complement(2459384) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2460698..2460717) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2460699) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2460701..2460897) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2460730..2460739) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2460880..2460899) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2460897) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2460911..2460917) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2460923..2463781) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" /label="sftA CDS" gene complement(2460923..2463781) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /label="sftA gene" promotor_-10 complement(2463815..2463834) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2463825) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="upshifts" promotor_-35 complement(2463850..2463854) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2463924) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" /label="downshifts" CDS complement(2463941..2464546) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" /label="ytpR CDS" gene complement(2463941..2464546) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /label="ytpR gene" CDS complement(2464562..2465371) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" /label="ytpQ CDS" gene complement(2464562..2465371) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /label="ytpQ gene" CDS complement(2465386..2465709) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" /label="ytpP CDS" gene complement(2465386..2465709) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /label="ytpP gene" S_feature complement(2465710..2465848) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2465748..2465864) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" /label="hypothetical protein CDS" gene complement(2465748..2465864) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /label="gene" promotor_-10 complement(2465835..2465854) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2465848) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="upshifts" promotor_-35 2465856..2465863 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2465878..2465897 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2465883 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="upshifts" CDS 2465944..2466390 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" /label="ytoQ CDS" gene 2465944..2466390 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /label="ytoQ gene" S_feature 2466391..2467119 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2466445..2467518) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" /label="ytoP CDS" gene complement(2466445..2467518) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /label="ytoP gene" downshifts complement(2466464) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2467540..2467559) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2467544) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2467573..2467580) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2467615..2467618 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2467633..2467652 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2467638 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="upshifts" CDS 2467677..2467994 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" /label="ytzB CDS" gene 2467677..2467994 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /label="ytzB gene" downshifts 2467994 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2468047..2469747) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" /label="maeC CDS" gene complement(2468047..2469747) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /label="maeC gene" downshifts complement(2468066) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2469779..2469797) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2469786) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2469812..2469818) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2469829..2470599) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" /label="ytnP CDS" gene complement(2469829..2470599) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /label="ytnP gene" S_feature complement(2470600..2470688) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2470686..2470705) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2470688) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2470721..2470725) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2470745..2471386) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" /label="trmB CDS" gene complement(2470745..2471386) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /label="trmB gene" downshifts complement(2470755) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(2470820) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2471412..2471431) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2471421) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2471423..2471871) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2471447..2471451) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2471530..2471536 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2471551..2471562 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2471558 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="upshifts" CDS 2471593..2471871 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" /label="ytzH CDS" gene 2471593..2471871 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /label="ytzH gene" S_feature 2471872..2472042 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2471872..2472486) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" /label="ytmP CDS" gene complement(2471872..2472486) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /label="ytmP gene" downshifts 2472020 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2472487..2472822) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2472814..2472833) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2472822) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2472848..2472855) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2472849..2475005) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" /label="amyX CDS" gene complement(2472849..2475005) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /label="amyX gene" Polymorphism join(2474546,2474548) /Source="geneious" /ID="SNP_BsDelta6_3063349_3063349" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=459 /Change="A -> G" /Codon_Change="GTT -> GTC" /Coverage=168 /locus_tag="BSU_29930" /Protein_Effect="None" /Reference_Frequency="1.2%" /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=165 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2475031..2475960) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" /label="ytlR CDS" gene complement(2475031..2475960) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /label="ytlR gene" CDS complement(2476009..2476923) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" /label="ytlQ CDS" gene complement(2476009..2476923) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /label="ytlQ gene" promotor_-10 complement(2476686..2476704) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2476694) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2476718..2476724) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2476949..2477500) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" /label="ytlP CDS" gene complement(2476949..2477500) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /label="ytlP gene" misc_feature 2477363..2477382 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2477366 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2477523..2477542) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2477535) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2477558..2477561) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2477583..2477590 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2477601..2477620 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2477604..2477615) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2477608 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2477618) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2477629..2477635) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2477649..2478584 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" /label="ytkP CDS" gene 2477649..2478584 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /label="ytkP gene" downshifts 2478560 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(2478618..2480009) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" /label="ytjP CDS" gene complement(2478618..2480009) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /label="ytjP gene" downshifts complement(2478630) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature complement(2480010..2480450) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2480036..2480041 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2480055..2480074 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2480068 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="upshifts" CDS 2480106..2481404 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" /label="pbuO CDS" gene 2480106..2481404 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /label="pbuO gene" promotor_-10 complement(2480427..2480446) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2480450) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2480461..2480467) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2481391 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2481444..2482601) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" /label="ythQ CDS" gene complement(2481444..2482601) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /label="ythQ gene" downshifts complement(2481469) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2481717..2481722 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2481737..2481755 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2481745 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2482598..2483308) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" /label="ythP CDS" gene complement(2482598..2483308) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /label="ythP gene" promotor_-10 complement(2483322..2483337) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2483339) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2483349..2483358) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2483365..2483366 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2483378..2483483 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2483378 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2483386..2483396 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2483449..2483455 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2483470..2483489 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2483485..2483598 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2483485 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2483599..2483820 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" /label="ytzE CDS" gene 2483599..2483820 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /label="ytzE gene" downshifts 2483803 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" /label="downshifts" downshifts 2483872 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2483941..2484660) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" /label="rsuA CDS" gene complement(2483941..2484660) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /label="rsuA gene" downshifts complement(2483955) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2484726) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" /label="downshifts" CDS complement(2484729..2486363) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" /label="murJ CDS" gene complement(2484729..2486363) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /label="murJ gene" misc_feature complement(2486395..2486414) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2486411) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2486481..2486485 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2486501..2486520 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2486519 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2486565..2487827 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" /label="ytfP CDS" gene 2486565..2487827 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /label="ytfP gene" S_feature 2487828..2487926 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2487900..2487906 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2487922..2487940 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2487928..2488015 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2487928 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2488016..2489554 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" /label="opuD CDS" gene 2488016..2489554 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /label="opuD gene" downshifts 2489534 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2489591..2489773) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" /label="yteV CDS" gene complement(2489591..2489773) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /label="yteV gene" downshifts complement(2489610) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2489788..2489806) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2489808) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2489822..2489827) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2489841..2490509) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" /label="rmgU CDS" gene complement(2489841..2490509) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /label="rmgU gene" CDS complement(2490531..2491817) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" /label="rmgT CDS" gene complement(2490531..2491817) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /label="rmgT gene" CDS complement(2491829..2492332) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" /label="rmgS CDS" gene complement(2491829..2492332) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /label="rmgS gene" CDS complement(2492329..2493450) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" /label="rmgQ CDS" gene complement(2492329..2493450) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /label="rmgQ gene" CDS complement(2493458..2494423) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" /label="rmgP CDS" gene complement(2493458..2494423) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /label="rmgP gene" upshifts complement(2494449) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2494450..2494469) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2494484..2494491) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2494579..2494586 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2494599 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2494602..2494621 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2494639..2496957 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" /label="rmgR CDS" gene 2494639..2496957 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /label="rmgR gene" downshifts 2496947 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" CDS complement(2496998..2498494) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" /label="ytcQ CDS" gene complement(2496998..2498494) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /label="ytcQ gene" downshifts complement(2497000) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2498519..2499379) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" /label="ytcP CDS" gene complement(2498519..2499379) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /label="ytcP gene" promotor_-10 complement(2499455..2499474) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2499464) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2499490..2499497) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2499586..2500347) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" /label="ytbQ CDS" gene complement(2499586..2500347) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /label="ytbQ gene" downshifts complement(2499615) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2500348..2500423) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2500424..2501611) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" /label="bioI CDS" gene complement(2500424..2501611) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /label="bioI gene" CDS complement(2501680..2502687) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" /label="bioB CDS" gene complement(2501680..2502687) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /label="bioB gene" CDS complement(2502690..2503385) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" /label="bioD CDS" gene complement(2502690..2503385) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /label="bioD gene" CDS complement(2503382..2504551) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" /label="bioFC CDS" gene complement(2503382..2504551) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /label="bioFC gene" promotor_-35 2503418..2503425 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2503440..2503459 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2503458 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2504541..2505887) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" /label="bioK CDS" gene complement(2504541..2505887) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /label="bioK gene" promotor_-35 2504957..2504961 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2504976 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2504977..2504995 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2505877..2506653) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" /label="bioW CDS" gene complement(2505877..2506653) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /label="bioW gene" S_feature complement(2506654..2506746) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2506732..2506751) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2506746) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2506766..2506773) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2506863..2507762) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" /label="ytaP CDS" gene complement(2506863..2507762) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /label="ytaP gene" promotor_-10 complement(2507785..2507803) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2507802) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2507814..2507822) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2507892..2507899 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2507915..2507934 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2507921 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2507980..2509014 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" /label="msmR CDS" gene 2507980..2509014 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /label="msmR gene" promotor_-35 2508963..2508970 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2508985..2508993 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2509002 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2509048..2510328 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" /label="msmE CDS" gene 2509048..2510328 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /label="msmE gene" CDS 2510321..2511232 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" /label="msmF CDS" gene 2510321..2511232 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /label="msmF gene" CDS 2511229..2512059 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" /label="msmG CDS" gene 2511229..2512059 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /label="msmG gene" promotor_-35 2512032..2512036 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2512052..2512071 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2512060 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2512079..2513377 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" /label="melA CDS" gene 2512079..2513377 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /label="melA gene" downshifts 2513358 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2513399..2513710) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" /label="ytwF CDS" gene complement(2513399..2513710) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /label="ytwF gene" downshifts complement(2513410) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2513734..2513753) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2513742) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2513768..2513775) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2513776 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS complement(2513827..2516241) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" /label="leuS CDS" gene complement(2513827..2516241) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /label="leuS gene" downshifts complement(2513831) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" S_feature complement(2516242..2516337) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2516351..2516565) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" /label="tboL RNA" gene complement(2516351..2516565) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /label="tboL gene" downshifts complement(2516382) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2516577..2516596) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2516598) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2516602..2516607 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2516611..2516616) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2516623..2516641 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2516636..2517076 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2516636 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2516668..2517003) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" /label="ytvB CDS" gene complement(2516668..2517003) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /label="ytvB gene" S_feature complement(2516998..2517262) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2517247..2517266) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2517262) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="upshifts" promotor_-35 complement(2517281..2517288) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2517301..2517308 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2517322..2517341 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2517338 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2517340..2517407 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2517408..2518193 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" /label="blrA CDS" gene 2517408..2518193 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /label="blrA gene" S_feature 2518194..2518250 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2518430..2519623) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" /label="yttB CDS" gene complement(2518430..2519623) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /label="yttB gene" downshifts complement(2518450) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2519624..2519722) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2519703..2519722) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2519722) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2519736..2519743) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2519760..2519763 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2519778..2519797 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2519782 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="upshifts" CDS 2519812..2520558 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" /label="yttA CDS" gene 2519812..2520558 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /label="yttA gene" downshifts 2520453 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" /label="downshifts" downshifts 2520552 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2520595..2522535) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" /label="bceB CDS" gene complement(2520595..2522535) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /label="bceB gene" downshifts complement(2520606) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2522525..2523286) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" /label="bceA CDS" gene complement(2522525..2523286) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /label="bceA gene" misc_feature complement(2523310..2523328) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2523329) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2523388..2524392) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" /label="bceS CDS" gene complement(2523388..2524392) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /label="bceS gene" downshifts complement(2523427) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2524385..2525080) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" /label="bceR CDS" gene complement(2524385..2525080) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /label="bceR gene" promotor_-10 complement(2525104..2525122) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2525116) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2525138..2525141) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2525177..2526487) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" /label="ytrF CDS" gene complement(2525177..2526487) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /label="ytrF gene" downshifts complement(2525199) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" /label="downshifts" CDS complement(2526477..2527172) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" /label="ytrE CDS" gene complement(2526477..2527172) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /label="ytrE gene" CDS complement(2527187..2528164) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" /label="ytrD CDS" gene complement(2527187..2528164) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /label="ytrD gene" CDS complement(2528194..2529180) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" /label="ytrC CDS" gene complement(2528194..2529180) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /label="ytrC gene" promotor_-35 2529050..2529059 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2529066 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2529072..2529087 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2529174..2530052) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" /label="ytrB CDS" gene complement(2529174..2530052) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /label="ytrB gene" CDS complement(2530045..2530437) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" /label="ytrA CDS" gene complement(2530045..2530437) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /label="ytrA gene" S_feature complement(2530438..2530682) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2530471..2530608) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" /label="conserved protein of unknown function CDS" gene complement(2530471..2530608) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /label="gene" downshifts 2530606 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2530677..2530696) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2530682) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2530710..2530717) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2530763..2531035) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" /label="ytzC CDS" gene complement(2530763..2531035) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /label="ytzC gene" downshifts complement(2530770) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2531075..2531086) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2531079..2531087 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2531079) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="upshifts" upshifts 2531090 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2531101..2531107) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2531101..2531119 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2531130..2531135 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2531149..2531168 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2531156 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="upshifts" CDS 2531197..2532165 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" /label="ytqA CDS" gene 2531197..2532165 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /label="ytqA gene" CDS 2532162..2532746 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" /label="ytqB CDS" gene 2532162..2532746 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /label="ytqB gene" downshifts 2532710 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2532736..>2532867) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /modified_by="User" /translation="LAKKLIKASGKTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC* " /label="IIG_Bs13_pseudo_BSU_30500" gene complement(2532736..>2532867) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /modified_by="User" /label="IIG_Bs13_pseudo_BSU_30500" downshifts complement(2532777) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR 2532870..2532871 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs13" S_feature complement(<2532871..2532886) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" promotor_-10 complement(2532877..2532896) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2532886) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2532888..2533022) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2532908..2532915) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2532997..2533016) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2533022) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2533115..2534506) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" /label="ytnA CDS" gene complement(2533115..2534506) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /label="ytnA gene" downshifts complement(2533123) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(2534507..2534641) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2534642..2536540) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" /label="asnB CDS" gene complement(2534642..2536540) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /label="asnB gene" promotor_-35 2535698..2535704 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2535719..2535730 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2535731 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2536541..2536664) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2536690..2537892) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" /label="metK CDS" gene complement(2536690..2537892) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /label="metK gene" downshifts complement(2536709) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2537935..2537946) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2537941) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2537943..2538059) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2537960..2537966) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2538060..2538198) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswG RNA" gene complement(2538060..2538198) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /label="mswG gene" downshifts 2538158 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2538207..2538226) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2538222) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="upshifts" promotor_-35 complement(2538243..2538247) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2538319..2538326 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2538338 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2538340..2538359 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2538395..2539978 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" /label="pckA CDS" gene 2538395..2539978 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /label="pckA gene" downshifts 2539967 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" /label="downshifts" CDS complement(2540017..2540259) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" /label="ytmB CDS" gene complement(2540017..2540259) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /label="ytmB gene" downshifts complement(2540031) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2540311..2541084) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" /label="ytmA CDS" gene complement(2540311..2541084) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /label="ytmA gene" S_feature complement(2541085..2541175) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2541151..2541160 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2541164..2541183) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2541172 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2541173..2541192 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2541177) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2541198..2541205) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2541235..2542239 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" /label="ytlA CDS" gene 2541235..2542239 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /label="ytlA gene" CDS 2542252..2543034 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" /label="ytlC CDS" gene 2542252..2543034 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /label="ytlC gene" S_feature complement(2542256..2543804) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2543009..2543821 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" /label="ytlD CDS" gene 2543009..2543821 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /label="ytlD gene" downshifts 2543806 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(2543848..2544324) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" /label="rppG CDS" gene complement(2543848..2544324) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /label="rppG gene" downshifts complement(2543849) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" /label="downshifts" misc_feature complement(2544354..2544373) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2544367) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2544369..2544503) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2544503) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2544505..2544516) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2544531..2544537) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2544533..2544937) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" /label="ytkC CDS" gene complement(2544533..2544937) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /label="ytkC gene" promotor_-10 complement(2544965..2544984) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2544982) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2544984..2545070) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2544997..2545006) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2545103..2545540) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" /label="dps CDS" gene complement(2545103..2545540) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /label="dps gene" downshifts complement(2545115) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2545557..2545575) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2545575) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2545577..2545802) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2545590..2545596) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2545632..2545651 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2545633..2545809 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" /label="ytzI CDS" gene 2545633..2545809 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /label="ytzI gene" upshifts 2545634 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2545803..2546240) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" /label="ytkA CDS" gene complement(2545803..2546240) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /label="ytkA gene" downshifts 2545829 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2546259..2546278) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2546280) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 complement(2546289..2546297) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2546360..2546833) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" /label="luxS CDS" gene complement(2546360..2546833) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /label="luxS gene" downshifts complement(2546369) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" /label="downshifts" downshifts complement(2546456) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" S_feature complement(2546834..2547185) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2546905..2546912 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2546925..2546944 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2546930 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2546962..2547189 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" /label="ytjA CDS" gene 2546962..2547189 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /label="ytjA gene" CDS complement(2547186..2547749) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" /label="ytiB CDS" gene complement(2547186..2547749) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /label="ytiB gene" misc_feature complement(2547774..2547793) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2547789) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2547843..2548091) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" /label="rpmEB CDS" gene complement(2547843..2548091) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /label="rpmEB gene" downshifts complement(2547864) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2548119..2548138) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2548152..2548159) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2548156) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 2548218..2548224 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2548238..2548249 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2548250 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="upshifts" CDS 2548296..2549627 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" /label="ythA CDS" gene 2548296..2549627 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /label="ythA gene" CDS 2549671..2550711 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" /label="ythB CDS" gene 2549671..2550711 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /label="ythB gene" promotor_-35 2550705..2550711 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2550726..2550737 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2550736 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="upshifts" CDS 2550765..2550923 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" /label="ytzL CDS" gene 2550765..2550923 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /label="ytzL gene" downshifts 2550912 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2550942..2551829) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" /label="mntD CDS" gene complement(2550942..2551829) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /label="mntD gene" downshifts complement(2550965) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" CDS complement(2551819..2553126) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" /label="mntC CDS" gene complement(2551819..2553126) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /label="mntC gene" CDS complement(2553132..2553884) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" /label="mntB CDS" gene complement(2553132..2553884) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /label="mntB gene" CDS complement(2553903..2554823) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" /label="mntA CDS" gene complement(2553903..2554823) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /label="mntA gene" promotor_-10 complement(2554859..2554870) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2554860) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2554862..2554953) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2554884..2554890) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2554938 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2554939..2554958) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2554941..2554953 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2554953) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2554955..2555036) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2554973..2554980) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2555036) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="upshifts" promotor_-10 complement(2555045..2555064) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2555078..2555085) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2555103..2556218) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" /label="menC CDS" gene complement(2555103..2556218) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /label="menC gene" downshifts complement(2555146) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2556215..2557675) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" /label="menE CDS" gene complement(2556215..2557675) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /label="menE gene" promotor_-10 complement(2557118..2557136) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2557122) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2557151..2557157) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2557764) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS complement(2557766..2558581) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" /label="menB CDS" gene complement(2557766..2558581) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /label="menB gene" CDS complement(2558616..2559440) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" /label="menH CDS" gene complement(2558616..2559440) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /label="menH gene" promotor_-10 complement(2558698..2558717) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2558698) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2558733..2558736) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2558864) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2558874..2558885) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2558900..2558906) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2559428..2561170) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" /label="menD CDS" gene complement(2559428..2561170) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /label="menD gene" CDS complement(2561167..2562582) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" /label="menF CDS" gene complement(2561167..2562582) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /label="menF gene" S_feature complement(2562583..2562695) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2562675..2562694) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2562695) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="upshifts" S_feature complement(2562697..2562847) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2562710..2562713) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2562808..2562814 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2562828..2562847) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2562828..2562839 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2562836 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2562847) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2562861..2562870) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2562872..2563591 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" /label="yteA CDS" gene 2562872..2563591 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /label="yteA gene" S_feature complement(2562942..2563599) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2563580 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2563600..2564418) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" /label="ytdA CDS" gene complement(2563600..2564418) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /label="ytdA gene" promotor_-10 complement(2564439..2564458) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2564453) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2564473..2564481) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2564519..2564527 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2564540..2564559 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2564541 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="upshifts" CDS 2564590..2565876 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" /label="ytcA CDS" gene 2564590..2565876 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /label="ytcA gene" CDS 2565873..2566823 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" /label="ytcB CDS" gene 2565873..2566823 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /label="ytcB gene" CDS 2566826..2568049 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" /label="ytcC CDS" gene 2566826..2568049 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /label="ytcC gene" downshifts complement(2567973) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2568050..2568617 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2568123..2568554) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" /label="cotOO CDS" gene complement(2568123..2568554) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /label="cotOO gene" downshifts complement(2568149) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(2568556..2569611) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" /label="cotS CDS" gene complement(2568556..2569611) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /label="cotS gene" CDS complement(2569626..2570759) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" /label="cotSA CDS" gene complement(2569626..2570759) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /label="cotSA gene" promotor_-10 complement(2570792..2570811) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2570811) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2570824..2570833) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2570897..2570906 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2570920..2570939 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2570922 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="upshifts" CDS 2570949..2572022 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" /label="cotI CDS" gene 2570949..2572022 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /label="cotI gene" promotor_-35 2571246..2571252 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2571263 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2571266..2571277 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2572011 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2572049..2572055 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2572070 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2572071..2572089 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2572102..2572569 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" /label="ytaB CDS" gene 2572102..2572569 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /label="ytaB gene" downshifts 2572541 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2572600..2574996) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" /label="glgP CDS" gene complement(2572600..2574996) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /label="glgP gene" downshifts complement(2572615) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2574983..2576437) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" /label="glgA CDS" gene complement(2574983..2576437) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /label="glgA gene" CDS complement(2576434..2577465) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" /label="glgD CDS" gene complement(2576434..2577465) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /label="glgD gene" CDS complement(2577489..2578631) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" /label="glgC CDS" gene complement(2577489..2578631) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /label="glgC gene" CDS complement(2578628..2580511) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" /label="glgB CDS" gene complement(2578628..2580511) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /label="glgB gene" S_feature 2579337..2580756 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2580543..2580558) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2580556) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2580573..2580578) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2580623) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" /label="downshifts" tRNA complement(2580744..2580815) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Glu tRNA" gene complement(2580744..2580815) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /label="trnB-Glu gene" tRNA complement(2580841..2580931) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser2 tRNA" gene complement(2580841..2580931) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /label="trnB-Ser2 gene" tRNA complement(2580935..2581009) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asn tRNA" gene complement(2580935..2581009) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /label="trnB-Asn gene" tRNA complement(2581020..2581096) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ile2 tRNA" gene complement(2581020..2581096) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /label="trnB-Ile2 gene" tRNA complement(2581112..2581185) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly2 tRNA" gene complement(2581112..2581185) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /label="trnB-Gly2 gene" tRNA complement(2581196..2581271) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-His tRNA" gene complement(2581196..2581271) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /label="trnB-His gene" tRNA complement(2581289..2581364) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Phe tRNA" gene complement(2581289..2581364) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /label="trnB-Phe gene" tRNA complement(2581377..2581453) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asp tRNA" gene complement(2581377..2581453) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /label="trnB-Asp gene" tRNA complement(2581465..2581541) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met2 tRNA" gene complement(2581465..2581541) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /label="trnB-Met2 gene" tRNA complement(2581559..2581651) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser1 tRNA" gene complement(2581559..2581651) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /label="trnB-Ser1 gene" tRNA complement(2581658..2581734) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met3 tRNA" gene complement(2581658..2581734) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /label="trnB-Met3 gene" tRNA complement(2581737..2581813) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met1 tRNA" gene complement(2581737..2581813) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /label="trnB-Met1 gene" tRNA complement(2581833..2581905) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ala tRNA" gene complement(2581833..2581905) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /label="trnB-Ala gene" tRNA complement(2581911..2581987) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Pro tRNA" gene complement(2581911..2581987) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /label="trnB-Pro gene" tRNA complement(2582003..2582079) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Arg tRNA" gene complement(2582003..2582079) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /label="trnB-Arg gene" tRNA complement(2582089..2582174) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu2 tRNA" gene complement(2582089..2582174) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /label="trnB-Leu2 gene" tRNA complement(2582189..2582263) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly1 tRNA" gene complement(2582189..2582263) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /label="trnB-Gly1 gene" tRNA complement(2582269..2582355) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu1 tRNA" gene complement(2582269..2582355) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /label="trnB-Leu1 gene" tRNA complement(2582366..2582441) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Lys tRNA" gene complement(2582366..2582441) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /label="trnB-Lys gene" tRNA complement(2582479..2582554) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Thr tRNA" gene complement(2582479..2582554) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /label="trnB-Thr gene" tRNA complement(2582587..2582662) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Val tRNA" gene complement(2582587..2582662) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /label="trnB-Val gene" rRNA complement(2582683..2582800) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-5S rRNA" gene complement(2582683..2582800) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /label="rrnB-5S gene" rRNA complement(2582856..2585783) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-23S rRNA" gene complement(2582856..2585783) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /label="rrnB-23S gene" rRNA complement(2585951..2587505) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-16S rRNA" gene complement(2585951..2587505) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /label="rrnB-16S gene" Polymorphism join(2587307,2587309) /Source="geneious" /ID="SNP_BsDelta6_3178443_3178443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="T -> C" /Codon_Change /Coverage=95 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="3.5e-102" /Variant_Raw_Frequency=94 /comment="rrnB-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" S_feature complement(2587506..2587797) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2587633..2587641 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2587639 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2587749 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2587770..2587789) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2587797) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2587799..2588765) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2587803..2587810) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2587922..2587925 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2587937 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2587940..2587959 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2587970..2588071 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswC RNA" gene 2587970..2588071 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /label="tswC gene" downshifts 2588070 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" /label="downshifts" CDS 2588171..2588749 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" /label="thiT CDS" gene 2588171..2588749 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /label="thiT gene" downshifts 2588739 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2588791..2589312) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" /label="yuaI CDS" gene complement(2588791..2589312) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /label="yuaI gene" downshifts complement(2588809) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" /label="downshifts" downshifts complement(2588881) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2589330..2590859) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" /label="floT CDS" gene complement(2589330..2590859) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /label="floT gene" CDS complement(2590880..2591404) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" /label="nfeDB CDS" gene complement(2590880..2591404) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /label="nfeDB gene" promotor_-10 complement(2591448..2591463) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(2591454) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="upshifts" S_feature complement(2591456..2591543) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(2591475..2591484) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(2591528..2591546) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2591538 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2591542..2591561 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2591543) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2591561..2591566) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2591572..2592060 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" /label="yuaE CDS" gene 2591572..2592060 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /label="yuaE gene" downshifts 2592037 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" /label="downshifts" CDS complement(2592066..2592644) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" /label="yuaD CDS" gene complement(2592066..2592644) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /label="yuaD gene" S_feature 2592082..2592473 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(2592093) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2592678..2592697) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2592687) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2592711..2592718) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2592732..2593940) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" /label="gbsB CDS" gene complement(2592732..2593940) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /label="gbsB gene" downshifts complement(2592753) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2593709..2593728) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2593721) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2593743..2593750) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2593957..2595429) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" /label="gbsA CDS" gene complement(2593957..2595429) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /label="gbsA gene" promotor_-10 complement(2595480..2595499) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2595481) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2595514..2595521) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2595541..2595547 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2595561..2595580 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2595576 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2595628..2596170 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" /label="gbsR CDS" gene 2595628..2596170 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /label="gbsR gene" downshifts 2596153 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2596247..2596254 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2596267..2596367 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 2596267 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2596269..2596288 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2596368..2596913 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" /label="bslA CDS" gene 2596368..2596913 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /label="bslA gene" downshifts 2596900 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2597005..2597012 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2597026..2597045 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2597033 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2597038..2597206 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" /label="swdA RNA" gene 2597038..2597206 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /label="swdA gene" downshifts 2597187 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 2597279..2597947 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" /label="ktrA CDS" gene 2597279..2597947 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /label="ktrA gene" CDS 2597954..2599291 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" /label="ktrB CDS" gene 2597954..2599291 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /label="ktrB gene" downshifts 2599277 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2599327..2599590) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" /label="yubF CDS" gene complement(2599327..2599590) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /label="yubF gene" downshifts complement(2599345) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2599630..2599649) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2599632) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2599662..2599669) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2599699..2600547) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" /label="lytG CDS" gene complement(2599699..2600547) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /label="lytG gene" promotor_-10 complement(2600592..2600611) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2600602) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2600626..2600633) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2600708..2602243) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" /label="yubD CDS" gene complement(2600708..2602243) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /label="yubD gene" downshifts complement(2600717) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 2601901..2602001 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2601961 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2602027 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature complement(2602244..2602411) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(2602400..2602419) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2602411) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2602413..2603290) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(2602434..2602441) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2602653..2602662 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2602676..2602695 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2602676 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="upshifts" CDS 2602728..2603213 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" /label="cdoA CDS" gene 2602728..2603213 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /label="cdoA gene" S_feature 2603214..2603500 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(2603320..2603392) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Ala1 tRNA" gene complement(2603320..2603392) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /label="trnSL-Ala1 gene" downshifts complement(2603335) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2603379) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2603403..2603422) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2603423) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2603437..2603440) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2603457 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2603500..2604330) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" /label="uppP CDS" gene complement(2603500..2604330) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /label="uppP gene" downshifts complement(2603511) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2604331..2604422) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(2604423..2605589) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" /label="yubA CDS" gene complement(2604423..2605589) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /label="yubA gene" promotor_-35 2605585..2605589 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2605597..2605611 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2605613..2605632) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2605613 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2605632) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2605646..2605653) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2605711..2605718 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2605724 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2605729..2605748 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2605771..2606784 /gene="iolU" /locus_tag="PG10_BSU_31170_3'_ext" /old_locus_tag="BSU_31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /modified_by="User" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQANSCQSA FSH*" /label="PG10_BSU_31170_3'_ext" gene 2605771..2606784 /gene="iolU" /locus_tag="PG10_BSU_31170_3'_ext" /old_locus_tag="BSU_31170" /modified_by="User" /label="PG10_BSU_31170_3'_ext" downshifts 2606728 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" SCAR join(2606753,2606760) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_029" N_region 2606754..2606759 /note="EcoRI site (GAATTC)" /created_by="User" /label="IIG_Bs27_029" CDS complement(2606781..2608133) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" /label="pgi CDS" gene complement(2606781..2608133) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /label="pgi gene" downshifts complement(2606792) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2606948..2606966) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2606965) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2606982..2606987) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2608106) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2608109..2608120) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2608165..2608184) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2608171) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2608173..2608244) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(2608199..2608202) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2608245..2609417) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" /label="bdhK CDS" gene complement(2608245..2609417) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /label="bdhK gene" S_feature 2608580..2609501 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(2609450..2609469) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(2609463) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="upshifts" promotor_-35 complement(2609486..2609489) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(2609521..2610684) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" /label="bdhJ CDS" gene complement(2609521..2610684) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /label="bdhJ gene" downshifts complement(2609536) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2610699..2610718) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(2610717) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="upshifts" S_feature complement(2610719..2610874) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(2610733..2610740) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 2610770..2610776 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2610791..2610809 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2610801 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2610802..2610860 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 2610847..2610853 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2610849..2610860) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2610862 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2610867..2610878 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2610874..2610880) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2610874) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2610876..2611187) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 2610914..2611150 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" /label="yuzA CDS" gene 2610914..2611150 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /label="yuzA gene" downshifts 2611110 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2611176 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2611228..2611620) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" /label="yugI CDS" gene complement(2611228..2611620) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /label="yugI gene" downshifts complement(2611232) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2611662..2611681) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(2611669) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="upshifts" S_feature complement(2611671..2611821) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(2611697..2611701) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 2611724..2611730 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2611737..2612721 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 2611737 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2611745..2611763 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2611822..2612982) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" /label="yugH CDS" gene complement(2611822..2612982) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /label="yugH gene" promotor_-35 2612874..2612880 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2612892 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2612894..2612898 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2612983..2613483) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" /label="yugG CDS" gene complement(2612983..2613483) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /label="yugG gene" promotor_-10 complement(2613513..2613532) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 2613519..2613525 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2613534) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="upshifts" promotor_-10 2613540..2613551 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2613540 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2613543..2613550) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 2613552..2613630 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 2613631..2614452 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" /label="yugF CDS" gene 2613631..2614452 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /label="yugF gene" downshifts 2614432 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2614479) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(2614481..2614741) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" /label="yugE CDS" gene complement(2614481..2614741) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /label="yugE gene" promotor_-35 2614731..2614734 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 2614749..2614768 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 2614761 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="upshifts" S_feature 2614762..2614827 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(2614767..2614786) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2614772) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2614798..2614804) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2614828..2615991 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" /label="patB CDS" gene 2614828..2615991 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /label="patB gene" promotor_-35 2616054..2616060 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2616072..2616091 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2616082 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2616117..2617403 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" /label="kinB CDS" gene 2616117..2617403 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /label="kinB gene" S_feature complement(2617119..2617861) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 2617398..2617405 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2617419..2617438 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2617420 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2617449..2617835 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" /label="kapB CDS" gene 2617449..2617835 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /label="kapB gene" downshifts 2617817 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2617862..2618479) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" /label="kapD CDS" gene complement(2617862..2618479) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /label="kapD gene" promotor_-10 complement(2618514..2618532) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2618531) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2618533..2620621) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(2618547..2618552) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2618595..2618598 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 2618613..2618632 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 2618624 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="upshifts" CDS 2618690..2619868 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" /label="yuxJ CDS" gene 2618690..2619868 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /label="yuxJ gene" promotor_-35 2619906..2619912 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2619924..2619943 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2619929 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="upshifts" CDS 2619961..2621835 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" /label="pbpD CDS" gene 2619961..2621835 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /label="pbpD gene" promotor_-10 complement(2620601..2620620) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2620621) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2620634..2620643) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2621856..2622269 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" /label="yuxK CDS" gene 2621856..2622269 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /label="yuxK gene" downshifts 2622261 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2622472..2623029) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" /label="yufK CDS" gene complement(2622472..2623029) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /label="yufK gene" misc_feature 2622493..2622512 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2622503 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2622513) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 2622525..2623206 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(2623055..2623074) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2623063) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2623090..2623094) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2623207..2624808 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" /label="maeL CDS" gene 2623207..2624808 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /label="maeL gene" CDS 2624801..2625508 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" /label="maeM CDS" gene 2624801..2625508 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /label="maeM gene" downshifts 2625493 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" /label="downshifts" promotor_-35 2625672..2625679 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2625690..2625979 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 2625690 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2625694..2625713 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2625980..2627059 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" /label="nupN CDS" gene 2625980..2627059 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /label="nupN gene" CDS 2627135..2628667 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" /label="nupO CDS" gene 2627135..2628667 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /label="nupO gene" CDS 2628660..2629706 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" /label="nupP CDS" gene 2628660..2629706 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /label="nupP gene" CDS 2629707..2630666 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" /label="nupQ CDS" gene 2629707..2630666 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /label="nupQ gene" S_feature 2630667..2630788 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 2630761..2630764 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2630779..2630798 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2630790 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="upshifts" CDS 2630820..2632166 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" /label="maeN CDS" gene 2630820..2632166 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /label="maeN gene" downshifts 2632149 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(2632202..2632417) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" /label="yufS CDS" gene complement(2632202..2632417) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /label="yufS gene" promotor_-35 2632357..2632363 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2632377..2632388 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2632381 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2632428..2632446) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2632435) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2632460..2632467 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2632462..2632467) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2632482..2632577 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 2632482..2632501 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2632482 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2632540..2632544 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2632560..2632579 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2632579..2632728 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 2632579 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2632648..2635053 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" /label="mrpA CDS" gene 2632648..2635053 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /label="mrpA gene" CDS 2635046..2635477 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" /label="mrpB CDS" gene 2635046..2635477 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /label="mrpB gene" CDS 2635477..2635818 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" /label="mrpC CDS" gene 2635477..2635818 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /label="mrpC gene" promotor_no_box 2635709..2635809 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2635769 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2635811..2637292 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" /label="mrpD CDS" gene 2635811..2637292 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /label="mrpD gene" S_feature complement(2636544..2638412) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 2637298..2637774 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" /label="mrpE CDS" gene 2637298..2637774 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /label="mrpE gene" CDS 2637774..2638058 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" /label="mrpF CDS" gene 2637774..2638058 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /label="mrpF gene" CDS 2638042..2638416 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" /label="mrpG CDS" gene 2638042..2638416 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /label="mrpG gene" downshifts 2638387 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2638455..2638835) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" /label="yuxO CDS" gene complement(2638455..2638835) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /label="yuxO gene" downshifts complement(2638457) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" /label="downshifts" CDS complement(2638854..2639498) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response quorum-sensing regulator" /protein_id="NP_391046.1" /db_xref="EnsemblGenomes-Gn:BSU31680" /db_xref="EnsemblGenomes-Tr:CAB15156" /db_xref="GOA:P14204" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2KRF" /db_xref="PDB:3ULQ" /db_xref="SubtiList:BG10381" /db_xref="UniProtKB/Swiss-Prot:P14204" /translation="MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQH DFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHG AISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL*" /label="comA CDS" gene complement(2638854..2639498) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /label="comA gene" S_feature complement(2639499..2639578) /Source="Nicolas_S_feature" /locus_tag="new_3253449_3253528_c" /HighExp="S2, Lbstat, M0t90, M40t90, MG 5, S1, ferm, T1.30H, nit, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1213" CDS complement(2639579..2641888) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /EC_number="2.7.-.-" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7698645, 7855425, 10419951, 14679219, 15066026, 16091050, 16787201, 20208433, 24130811; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_391047.2" /db_xref="EnsemblGenomes-Gn:BSU31690" /db_xref="EnsemblGenomes-Tr:CAB15157" /db_xref="GOA:Q99027" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10380" /db_xref="UniProtKB/Swiss-Prot:Q99027" /translation="MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQ FMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHL KDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIF NLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLIL TNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILG RMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFR LKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKV IFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINT PRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEK QRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVIS MTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLY RIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGI KERVRALDGRLRIETSEGKGFKADIEIEL*" /label="comP CDS" gene complement(2639579..2641888) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /label="comP gene" promotor_-35 2640573..2640580 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2640594..2640613 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2640609 /Source="Nicolas_upshifts" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 2641482..2642453 /Source="Nicolas_S_feature" /locus_tag="new_3255432_3256404" /HighExp="S8, C30, S7, Gly, Lbstat, Fru, C90, Pyr, G135, M/G" /AntisenseName="comX" /AntisenseCor="-2.6572990440080099E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.606" /TUlongSig="NA" /TUlongPSig="NA" /label="S1214" upshifts 2641482 /Source="Nicolas_upshifts" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2641494..2641510 /Source="Nicolas_upshift_promotors" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2641903..2642070) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484; Product type f: factor" /codon_start=1 /transl_table=11 /product="competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified)" /protein_id="NP_391048.1" /db_xref="EnsemblGenomes-Gn:BSU31700" /db_xref="EnsemblGenomes-Tr:CAB15158" /db_xref="GOA:P45453" /db_xref="InterPro:IPR009233" /db_xref="SubtiList:BG11324" /db_xref="UniProtKB/Swiss-Prot:P45453" /translation="MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYY LADPITRQWGD*" /label="comX CDS" gene complement(2641903..2642070) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /label="comX gene" CDS complement(2642058..2642956) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoprenyl transferase (pre-ComX modification)" /protein_id="NP_391049.2" /db_xref="EnsemblGenomes-Gn:BSU31710" /db_xref="EnsemblGenomes-Tr:CAB15159" /db_xref="GOA:P33690" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033965" /db_xref="SubtiList:BG10379" /db_xref="UniProtKB/Swiss-Prot:P33690" /translation="MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGE NLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSI YSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGV LLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDA SEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLD KEKKS**RNAY*VIQRGIQDARP" /label="comQ CDS" gene complement(2642058..2642956) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /label="comQ gene" S_feature complement(2642957..2643070) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1215" promotor_-10 complement(2643064..2643083) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2643070) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2643097..2643103) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2643141..2643281) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" /label="degQ CDS" gene complement(2643141..2643281) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /label="degQ gene" downshifts complement(2643170) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2643282..2643368) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(2643352..2643371) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2643368) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2643385..2643391) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2643468..2643486) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2643478) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2643501..2643507) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2643503..2643628 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" /label="hypothetical protein CDS" gene 2643503..2643628 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /label="gene" S_feature complement(2643656..2644085) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 2643681..2643686 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2643698) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 2643701..2643719 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2643703 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="upshifts" CDS 2643742..2644110 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" /label="cotIC CDS" gene 2643742..2644110 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /label="cotIC gene" CDS complement(2644086..2645315) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" /label="pdeH CDS" gene complement(2644086..2645315) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /label="pdeH gene" S_feature 2644111..2645424 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(2645350..2645369) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2645369) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="upshifts" downshifts 2645382 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2645384..2645391) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2645452..2646924) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" /label="pncB CDS" gene complement(2645452..2646924) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /label="pncB gene" downshifts complement(2645462) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" misc_feature 2646805..2646809 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2646812 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2646922 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS complement(2646940..2647491) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" /label="pncA CDS" gene complement(2646940..2647491) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /label="pncA gene" promotor_-10 complement(2647513..2647532) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2647526) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2647545..2647552) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2647588..2647986) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" /label="yueI CDS" gene complement(2647588..2647986) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /label="yueI gene" S_feature complement(2647987..2648057) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(2648058..2648306) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" /label="yueH CDS" gene complement(2648058..2648306) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /label="yueH gene" promotor_-10 complement(2648329..2648348) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2648340) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2648364..2648367) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2648379..2648600) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" /label="yueG CDS" gene complement(2648379..2648600) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /label="yueG gene" downshifts complement(2648406) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2648594 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2648618..2648637) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2648624) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2648650..2648659) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2648660..2649769) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" /label="yueF CDS" gene complement(2648660..2649769) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /label="yueF gene" promotor_-35 2649421..2649428 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2649443..2649462 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2649452..2649846 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 2649452 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2649817..2649836) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(2649833) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="upshifts" S_feature complement(2649835..2650275) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 2649838..2649840 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2649848 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2649850..2649855) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 2649856..2649875 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2649884..2650273 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" /label="yuzE CDS" gene 2649884..2650273 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /label="yuzE gene" CDS complement(2650314..2650550) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" /label="yuzF CDS" gene complement(2650314..2650550) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /label="yuzF gene" downshifts complement(2650320) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2650570..2650589) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2650584) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2650586..2650726) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(2650603..2650612) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2650727..2651257) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" /label="yueE CDS" gene complement(2650727..2651257) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /label="yueE gene" promotor_-10 complement(2651277..2651296) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(2651288) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="upshifts" S_feature complement(2651290..2651376) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(2651308..2651316) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(2651371..2651390) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2651378) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2651404..2651413) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2651455..2652186) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" /label="bznD CDS" gene complement(2651455..2652186) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /label="bznD gene" downshifts complement(2651485) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2652201..2652220) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2652212) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2652235..2652242) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2652249..2652704) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" /label="yueC CDS" gene complement(2652249..2652704) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /label="yueC gene" promotor_-35 2652657..2652663 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2652678..2652696 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2652686..2655053 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 2652686 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2652736..2655966) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" /label="yueB CDS" gene complement(2652736..2655966) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /label="yueB gene" CDS complement(2655963..2660450) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" /label="yukAB CDS" gene complement(2655963..2660450) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /label="yukAB gene" promotor_-35 2659725..2659731 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2659746..2659764 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2659752..2660714 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 2659752 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2660511..2661866) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" /label="yukC CDS" gene complement(2660511..2661866) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /label="yukC gene" downshifts complement(2660532) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" /label="downshifts" CDS complement(2661881..2662120) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" /label="yukD CDS" gene complement(2661881..2662120) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /label="yukD gene" CDS complement(2662190..2662483) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" /label="yukE CDS" gene complement(2662190..2662483) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /label="yukE gene" downshifts complement(2662200) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" /label="downshifts" downshifts 2662477 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" S_feature complement(2662484..2662562) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 2662525..2662532 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2662542..2662561) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2662543 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2662547..2662564 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2662562) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2662576..2662583) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2662621..2662626 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2662641..2662660 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2662653..2662759 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 2662653 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2662828..2662834 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2662848..2662867 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2662851 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2662956..2662959 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 2662968 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="upshifts" promotor_-10 complement(2662971..2662990) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2662975..2662994 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(2662993) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2663004..2664272 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" /label="adeR CDS" gene 2663004..2664272 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /label="adeR gene" promotor_-35 complement(2663005..2663012) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2664332..2664351 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2664337 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2664374..2665510 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" /label="ald CDS" gene 2664374..2665510 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /label="ald gene" downshifts 2665510 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" /label="downshifts" promotor_-35 2665559..2665567 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2665577 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2665579..2665597 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2665622..2666299 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" /label="yukJ CDS" gene 2665622..2666299 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /label="yukJ gene" downshifts 2666283 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2666343..2666552) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" /label="mbtH CDS" gene complement(2666343..2666552) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /label="mbtH gene" downshifts complement(2666355) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2666568..2673704) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" /label="dhbF CDS" gene complement(2666568..2673704) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /label="dhbF gene" CDS complement(2673724..2674662) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" /label="dhbB CDS" gene complement(2673724..2674662) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /label="dhbB gene" CDS complement(2674690..2676309) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" /label="dhbE CDS" gene complement(2674690..2676309) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /label="dhbE gene" CDS complement(2676338..2677534) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" /label="dhbC CDS" gene complement(2676338..2677534) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /label="dhbC gene" promotor_-35 2677382..2677389 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2677404..2677423 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2677411 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2677560..2678345) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" /label="dhbA CDS" gene complement(2677560..2678345) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /label="dhbA gene" S_feature complement(2678346..2678455) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(2678450..2678469) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2678455) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2678457..2678538) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(2678483..2678490) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2678539..2679408) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" /label="besA CDS" gene complement(2678539..2679408) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /label="besA gene" S_feature complement(2679409..2679489) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(2679473..2679492) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2679489) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2679506..2679513) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2679622..2680218) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" /label="yuiH CDS" gene complement(2679622..2680218) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /label="yuiH gene" S_feature complement(2680219..2680303) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 2680254..2680261 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2680271 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2680276..2680295 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2680297..2680311) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2680303) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2680319..2680323) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2680319..2680921 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" /label="bioYB CDS" gene 2680319..2680921 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /label="bioYB gene" downshifts 2680907 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" CDS complement(2680991..2682319) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" /label="hisP CDS" gene complement(2680991..2682319) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /label="hisP gene" downshifts complement(2681007) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2682373..2682392) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2682376) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2682407..2682414) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2682466..2683968) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" /label="pepA CDS" gene complement(2682466..2683968) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /label="pepA gene" downshifts complement(2682481) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2683533..2683547 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2683549 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2683969..2684043) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 2683991..2683998 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2684009..2684028 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2684011..2684125 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 2684011 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2684038..2684057) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2684048) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="upshifts" CDS 2684126..2684602 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" /label="yuiD CDS" gene 2684126..2684602 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /label="yuiD gene" downshifts 2684551 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" /label="downshifts" CDS complement(2684633..2685289) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" /label="spsC CDS" gene complement(2684633..2685289) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /label="spsC gene" downshifts complement(2684661) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2684937..2684946 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2684960..2684979 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2684977 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="upshifts" S_feature 2684979..2685425 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(2685303) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2685305..2685316) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2685331..2685337) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2685382 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" /label="downshifts" CDS complement(2685393..2685713) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" /label="yuiB CDS" gene complement(2685393..2685713) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /label="yuiB gene" downshifts complement(2685407) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" /label="downshifts" S_feature 2685427..2685637 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 2685579..2685679 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2685639..2685748 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 2685639 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="upshifts" downshifts 2685705 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2685732..2685751) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2685737) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" S_feature 2685750..2686301 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(2685766..2685773) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2685767..2685910) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" /label="yuiA CDS" gene complement(2685767..2685910) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /label="yuiA gene" promotor_-10 complement(2685934..2685953) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2685955) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2685969..2685972) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2686083..2687303) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" /label="yumB CDS" gene complement(2686083..2687303) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /label="yumB gene" downshifts complement(2686111) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2687304..2687431) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(2687431) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2687433..2687497) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(2687433..2687451) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2687467..2687472) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2687488..2687507) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2687496) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2687522..2687529) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2687571..2687578 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2687590..2687609 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2687590 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="upshifts" CDS 2687635..2688633 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" /label="trxBB CDS" gene 2687635..2688633 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /label="trxBB gene" promotor_-10 complement(2687658..2687676) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2687673) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2687693..2687698) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2688609 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2688672..2688812) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" /label="yuzG CDS" gene complement(2688672..2688812) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /label="yuzG gene" downshifts complement(2688684) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2688813..2688942) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(2688923..2688942) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2688942) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2688944..2689191) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(2688956..2688962) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2688999..2689006 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2689020..2689039 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2689028 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2689091..2690071 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" /label="guaC CDS" gene 2689091..2690071 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /label="guaC gene" upshifts complement(2689192) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2689196..2689207) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2689221..2689227) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2690039 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2690144) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2690145..2690768) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" /label="paiB CDS" gene complement(2690145..2690768) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /label="paiB gene" CDS complement(2690792..2691310) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" /label="paiA CDS" gene complement(2690792..2691310) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /label="paiA gene" misc_feature complement(2691357..2691376) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2691369) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2691371..2691479) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(2691466..2691483) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2691477) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2691498..2691505) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2691633) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2691648..2692010) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" /label="sufA CDS" gene complement(2691648..2692010) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /label="sufA gene" promotor_-10 complement(2692041..2692060) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2692051) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2692074..2692081) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2692089..2692943) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" /label="dapF CDS" gene complement(2692089..2692943) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /label="dapF gene" promotor_-10 complement(2692659..2692678) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2692667) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2692691..2692700) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2692965..2692984) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2692979) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2692999..2693002) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2693066..2694280) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" /label="yutK CDS" gene complement(2693066..2694280) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /label="yutK gene" promotor_-35 2693615..2693621 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2693636..2693654 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2693643 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="upshifts" S_feature 2693647..2694416 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(2694317..2694336) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(2694322) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="upshifts" promotor_-35 complement(2694351..2694358) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 2694373 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" /label="downshifts" CDS complement(2694417..2694653) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" /label="yuzB CDS" gene complement(2694417..2694653) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /label="yuzB gene" S_feature 2694418..2694834 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(2694435) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2694618..2694619) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2694623..2694627) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2694625) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2694668..2694687) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2694669) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2694701..2694708) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2694811..2694816 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2694830..2694849 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2694836 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="upshifts" CDS 2694916..2695983 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" /label="yutJ CDS" gene 2694916..2695983 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /label="yutJ gene" downshifts 2695967 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" /label="downshifts" CDS complement(2696009..2696335) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" /label="yuzD CDS" gene complement(2696009..2696335) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /label="yuzD gene" downshifts complement(2696032) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2696367..2696386) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2696384) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2696399..2696406) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2696419..2696423 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2696435..2696770 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" /label="yutI CDS" gene 2696435..2696770 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /label="yutI gene" promotor_-10 2696436..2696455 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2696441 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2696560) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2696748 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2696812..2698785) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" /label="yuxL CDS" gene complement(2696812..2698785) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /label="yuxL gene" downshifts complement(2696824) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2698800..2698818) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2698823) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2698830..2698838) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2698893..2699822) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" /label="thrB CDS" gene complement(2698893..2699822) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /label="thrB gene" downshifts complement(2698906) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2699819..2700877) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" /label="thrC CDS" gene complement(2699819..2700877) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /label="thrC gene" CDS complement(2700877..2702178) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" /label="hom CDS" gene complement(2700877..2702178) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /label="hom gene" promotor_-35 2702063..2702072 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2702087..2702106 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2702094 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2702179..2702260) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(2702245..2702264) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2702260) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2702262..2702378) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(2702279..2702286) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2702379..2703398) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" /label="cotNH CDS" gene complement(2702379..2703398) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /label="cotNH gene" promotor_-35 2703206..2703211 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2703227..2703245 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2703231 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2703421..2703439) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2703428) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2703437..2703442 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2703455..2703460) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2703458..2703522 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 2703458..2703476 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2703458 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2703495..2703504 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2703517..2703536 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2703524 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="upshifts" CDS 2703551..2704051 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" /label="yutG CDS" gene 2703551..2704051 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /label="yutG gene" CDS complement(2704078..2704848) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" /label="nucF CDS" gene complement(2704078..2704848) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /label="nucF gene" downshifts complement(2704106) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2704877..2705311) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" /label="yutE CDS" gene complement(2704877..2705311) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /label="yutE gene" CDS complement(2705335..2705610) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" /label="yutD CDS" gene complement(2705335..2705610) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /label="yutD gene" promotor_-10 complement(2705630..2705649) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2705655) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2705657..2706349) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(2705663..2705670) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2705673..2705679 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2705694..2705705 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2705702 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="upshifts" CDS 2705725..2706357 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" /label="yutC CDS" gene 2705725..2706357 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /label="yutC gene" downshifts 2706318 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2706373..2707269) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" /label="lipA CDS" gene complement(2706373..2707269) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /label="lipA gene" downshifts complement(2706394) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(2707270..2707404) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(2707391..2707410) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(2707404) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="upshifts" promotor_-35 complement(2707426..2707430) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 2707444..2707450 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2707464..2707475 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2707476 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="upshifts" CDS 2707504..2708484 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" /label="lytH CDS" gene 2707504..2708484 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /label="lytH gene" upshifts complement(2707582) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2707596..2707615) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2707632..2707635) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2708476 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2708512..2709276) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" /label="fisB CDS" gene complement(2708512..2709276) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /label="fisB gene" downshifts complement(2708528) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2709290..2709308) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2709298) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2709324..2709329) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2709349..2709654) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " /label="yunC CDS" gene complement(2709349..2709654) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /label="yunC gene" downshifts complement(2709357) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2709668..2709687) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2709691) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2709701..2709709) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2709719..2711107) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" /label="yunD CDS" gene complement(2709719..2711107) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /label="yunD gene" CDS complement(2711127..2711948) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" /label="yunE CDS" gene complement(2711127..2711948) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /label="yunE gene" CDS complement(2711966..2712814) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" /label="yunF CDS" gene complement(2711966..2712814) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /label="yunF gene" promotor_-35 2712333..2712338 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2712354..2712372 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2712368 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2712825..2712844) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2712840) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2712852..2713199) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" /label="yunG CDS" gene complement(2712852..2713199) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /label="yunG gene" promotor_-10 complement(2713212..2713231) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2713231) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2713245..2713251) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2713296..2714636) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" /label="pucH CDS" gene complement(2713296..2714636) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /label="pucH gene" downshifts complement(2713324) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" /label="downshifts" downshifts complement(2714380) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" /label="downshifts" promotor_-35 2714693..2714699 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2714713..2714732 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2714715..2714733) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2714721 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2714722..2714810 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(2714732) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2714749..2714754) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2714811..2716406 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" /label="pucR CDS" gene 2714811..2716406 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /label="pucR gene" CDS 2716551..2717900 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " /label="pucJ CDS" gene 2716551..2717900 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /label="pucJ gene" CDS 2717906..2719198 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" /label="pucK CDS" gene 2717906..2719198 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /label="pucK gene" CDS 2719211..2720695 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" /label="pucL CDS" gene 2719211..2720695 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /label="pucL gene" CDS 2720695..2721039 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" /label="pucM CDS" gene 2720695..2721039 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /label="pucM gene" promotor_-35 2720761..2720764 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2720782..2720801 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2720794 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2721014 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2721055..2721442) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 2721402..2721411 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2721424..2721443 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2721427 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="upshifts" ncRNA complement(2721463..2721594) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" /label="auzJ ncRNA" CDS 2721463..2721594 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " /label="yuzJ CDS" gene 2721463..2721594 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /label="yuzJ gene" gene complement(2721463..2721594) /gene="auzJ" /locus_tag="BSU_ncRNA_2" /label="auzJ gene" S_feature 2721595..2721663 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 2721630 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2721800..2722321) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" /label="pucE CDS" gene complement(2721800..2722321) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /label="pucE gene" CDS complement(2722312..2724549) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" /label="pucD CDS" gene complement(2722312..2724549) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /label="pucD gene" CDS complement(2724550..2725383) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" /label="pucC CDS" gene complement(2724550..2725383) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /label="pucC gene" CDS complement(2725380..2725997) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" /label="pucB CDS" gene complement(2725380..2725997) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /label="pucB gene" downshifts complement(2725489) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" /label="downshifts" CDS complement(2725994..2726986) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" /label="pucA CDS" gene complement(2725994..2726986) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /label="pucA gene" S_feature complement(2726987..2727073) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(2727051..2727070) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2727073) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2727084..2727089) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2727215..2728465) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" /label="pucG CDS" gene complement(2727215..2728465) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /label="pucG gene" CDS complement(2728482..2729720) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" /label="pucF CDS" gene complement(2728482..2729720) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /label="pucF gene" CDS 2729943..2730080 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" /label="hypothetical protein CDS" gene 2729943..2730080 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /label="gene" promotor_-35 2730102..2730105 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2730120..2730139 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2730121 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="upshifts" CDS 2730162..2731028 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" /label="bsnA CDS" gene 2730162..2731028 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /label="bsnA gene" downshifts 2731031 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2731062..2732165) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" /label="frlP CDS" gene complement(2731062..2732165) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /label="frlP gene" downshifts complement(2731077) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2732166..2733099) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 2732203..2732210 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2732224..2732243 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2732234 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2732285..2732291 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2732302 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2732306..2732325 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2732347..2733075 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" /label="frlR CDS" gene 2732347..2733075 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /label="frlR gene" CDS complement(2733100..2733954) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" /label="frlD CDS" gene complement(2733100..2733954) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /label="frlD gene" misc_feature complement(2733287..2733306) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2733299) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2733457..2733557) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2733497) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2733968..2734870) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" /label="frlM CDS" gene complement(2733968..2734870) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /label="frlM gene" CDS complement(2734874..2735752) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" /label="frlN CDS" gene complement(2734874..2735752) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /label="frlN gene" CDS complement(2735810..2737078) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" /label="frlO CDS" gene complement(2735810..2737078) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /label="frlO gene" promotor_no_box 2736969..2737069 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2737029 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2737149) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS complement(2737159..2738145) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" /label="frlB CDS" gene complement(2737159..2738145) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /label="frlB gene" upshifts 2738092 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2738095..2738099 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2738188..2738207) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2738201) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2738222..2738229) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2738359) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2738361..2738735) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" /label="yurQ CDS" gene complement(2738361..2738735) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /label="yurQ gene" upshifts complement(2738799) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2738806..2738817) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2738831..2738837) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2738838..2739956) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" /label="dadA CDS" gene complement(2738838..2739956) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /label="dadA gene" promotor_-10 complement(2739981..2740000) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2739987) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2739989..2740599) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(2740014..2740020) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2740053..2740062 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2740076..2740095 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2740080 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2740093..2740108) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2740097) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2740115..2740119) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2740115..2740261 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" /label="sspG CDS" gene 2740115..2740261 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /label="sspG gene" CDS 2740261..2740536 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" /label="yurS CDS" gene 2740261..2740536 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /label="yurS gene" upshifts complement(2740405) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2740421..2740435) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2740444..2740448) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2740516 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2740600..2740983) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" /label="glxB CDS" gene complement(2740600..2740983) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /label="glxB gene" S_feature complement(2740984..2741093) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(2741094..2741372) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" /label="yuzN CDS" gene complement(2741094..2741372) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /label="yuzN gene" promotor_-10 complement(2741370..2741389) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2741394) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2741404..2741411) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2741535..2741641) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(2741578) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2741642..2743039) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" /label="sufB CDS" gene complement(2741642..2743039) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /label="sufB gene" downshifts 2742837 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS complement(2743060..2743503) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" /label="sufU CDS" gene complement(2743060..2743503) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /label="sufU gene" CDS complement(2743493..2744713) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" /label="sufS CDS" gene complement(2743493..2744713) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /label="sufS gene" CDS complement(2744713..2746026) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" /label="sufD CDS" gene complement(2744713..2746026) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /label="sufD gene" CDS complement(2746044..2746829) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" /label="sufC CDS" gene complement(2746044..2746829) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /label="sufC gene" promotor_-10 complement(2746873..2746892) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2746874) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" promotor_-35 complement(2746906..2746913) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(2746930..2746949) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2746939) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" S_feature complement(2746941..2747022) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(2746965..2746969) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(2746986..2747233) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" /label="bsrI RNA" gene complement(2746986..2747233) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /label="bsrI gene" CDS complement(2747023..2747160) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" /label="yuzK CDS" gene complement(2747023..2747160) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /label="yuzK gene" S_feature complement(2747161..2747245) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(2747229..2747248) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2747245) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2747247..2747353) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(2747264..2747267) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2747354..2747731) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" /label="yurZ CDS" gene complement(2747354..2747731) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /label="yurZ gene" promotor_-10 complement(2747748..2747759) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(2747754) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="upshifts" promotor_-35 complement(2747773..2747779) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(2747816..2748640) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" /label="metQ CDS" gene complement(2747816..2748640) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /label="metQ gene" downshifts complement(2747824) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2747973) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-35 2748000..2748005 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2748021..2748039 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2748023 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2748654..2749322) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" /label="metP CDS" gene complement(2748654..2749322) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /label="metP gene" CDS complement(2749315..2750340) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" /label="metN CDS" gene complement(2749315..2750340) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /label="metN gene" S_feature complement(2750341..2750445) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(2750446..2750552) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswH RNA" gene complement(2750446..2750552) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /label="mswH gene" downshifts 2750515 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2750579..2750598) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2750591) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2750593..2750666) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(2750614..2750621) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2750667..2751011) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" /label="yusD CDS" gene complement(2750667..2751011) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /label="yusD gene" S_feature complement(2751012..2751117) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(2751118..2751438) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" /label="yusE CDS" gene complement(2751118..2751438) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /label="yusE gene" CDS complement(2751440..2751880) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" /label="yusF CDS" gene complement(2751440..2751880) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /label="yusF gene" CDS complement(2751880..2752116) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" /label="yusG CDS" gene complement(2751880..2752116) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /label="yusG gene" downshifts complement(2751892) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" /label="downshifts" upshifts complement(2752131) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2752136..2752147) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2752162..2752168) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2752172..2752555) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" /label="gcvH CDS" gene complement(2752172..2752555) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /label="gcvH gene" promotor_-10 complement(2752582..2752601) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(2752593) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="upshifts" promotor_-35 complement(2752614..2752621) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(2752622..2752978) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" /label="yusI CDS" gene complement(2752622..2752978) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /label="yusI gene" promotor_-10 complement(2753001..2753020) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(2753011) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="upshifts" promotor_-35 complement(2753034..2753039) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(2753089..2754873) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" /label="fadE CDS" gene complement(2753089..2754873) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /label="fadE gene" downshifts complement(2753099) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2754888..2756063) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " /label="fadA CDS" gene complement(2754888..2756063) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /label="fadA gene" CDS complement(2756074..2758443) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" /label="fadN CDS" gene complement(2756074..2758443) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /label="fadN gene" promotor_-35 2757862..2757867 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2757882..2757900 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2757885 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2758511..2758530) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(2758514) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="upshifts" S_feature complement(2758522..2758788) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(2758544..2758551) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 2758569..2758575 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2758590..2758601 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2758612 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="upshifts" CDS 2758618..2758764 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" /label="yuzL CDS" gene 2758618..2758764 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /label="yuzL gene" S_feature 2758765..2759791 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(2758789..2759697) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" /label="putM CDS" gene complement(2758789..2759697) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /label="putM gene" S_feature complement(2759698..2760220) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 2759792..2760037 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" /label="yuzM CDS" gene 2759792..2760037 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /label="yuzM gene" CDS 2760050..2760382 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" /label="yusN CDS" gene 2760050..2760382 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /label="yusN gene" promotor_-10 complement(2760203..2760222) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2760220) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2760236..2760245) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2760371 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2760443..2760450 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2760464..2760483 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2760475 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="upshifts" CDS 2760541..2761008 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" /label="mdtR CDS" gene 2760541..2761008 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /label="mdtR gene" CDS 2761005..2762630 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" /label="mdtP CDS" gene 2761005..2762630 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /label="mdtP gene" downshifts 2762615 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2762666..2763049) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" /label="yusQ CDS" gene complement(2762666..2763049) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /label="yusQ gene" CDS complement(2763068..2763457) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" /label="yusR CDS" gene complement(2763068..2763457) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /label="yusR gene" CDS complement(2763479..2763808) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" /label="yusS CDS" gene complement(2763479..2763808) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /label="yusS gene" promotor_-10 complement(2763843..2763862) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2763850..2763857 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2763857) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2763872..2763891 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2763876..2763883) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2763882 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="upshifts" CDS 2763942..2764829 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" /label="yusT CDS" gene 2763942..2764829 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /label="yusT gene" CDS complement(2764849..2765136) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" /label="yusU CDS" gene complement(2764849..2765136) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /label="yusU gene" downshifts complement(2764861) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2765161..2765988) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " /label="feuV CDS" gene complement(2765161..2765988) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /label="feuV gene" downshifts complement(2765177) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" /label="downshifts" S_feature complement(2765989..2766126) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(2766111..2766130) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2766126) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2766146..2766149) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2766206..2766643) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" /label="cotNW CDS" gene complement(2766206..2766643) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /label="cotNW gene" promotor_-10 complement(2766667..2766685) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(2766673) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="upshifts" promotor_-35 complement(2766701..2766706) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(2766753..2768261) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" /label="yusYc CDS" gene complement(2766753..2768261) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo /label="yusYc gene" downshifts complement(2766774) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(2768252..2768548) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" /label="yusYn CDS" gene complement(2768252..2768548) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo /label="yusYn gene" promotor_-10 complement(2768571..2768590) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2768587) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2768605..2768608) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2768625..2768630 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2768642..2768661 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2768642 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="upshifts" CDS 2768682..2769524 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" /label="yusZ CDS" gene 2768682..2769524 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /label="yusZ gene" promotor_-35 2769054..2769060 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 2769075..2769086 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 2769083 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="upshifts" promotor_-35 2769551..2769558 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2769567 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2769570..2769589 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2769614..2770075 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" /label="mrgA CDS" gene 2769614..2770075 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /label="mrgA gene" downshifts 2770051 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2770119..2771495) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" /label="htrB CDS" gene complement(2770119..2771495) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /label="htrB gene" downshifts complement(2770127) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2771496..2771667) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(2771648..2771667) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2771667) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2771678..2771685) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2771728..2771747) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 2771738..2771757 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2771740 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2771746) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="upshifts" S_feature complement(2771748..2772811) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(2771762..2771769) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 2771773..2772450 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" /label="cssR CDS" gene 2771773..2772450 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /label="cssR gene" CDS 2772447..2773802 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" /label="cssS CDS" gene 2772447..2773802 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /label="cssS gene" S_feature complement(2772901..2773829) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 2773770 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2773830..2773994) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" /label="spxO CDS" gene complement(2773830..2773994) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /label="spxO gene" promotor_-35 2774018..2774025 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2774039..2774058 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2774043..2774062) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2774049..2774161 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 2774049 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2774056) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2774058..2774336) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(2774076..2774083) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2774162..2775037 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" /label="yuxN CDS" gene 2774162..2775037 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /label="yuxN gene" promotor_-10 complement(2774326..2774345) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2774336) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2774338..2774879) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(2774359..2774366) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2774871..2774889) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2774879) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2774881..2775010) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(2774902..2774909) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2775012 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" downshifts complement(2775055) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(2775073..2776461) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" /label="fumC CDS" gene complement(2775073..2776461) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /label="fumC gene" upshifts complement(2776485) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2776490..2776508) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2776519..2776527) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2776528..2776713) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" /label="yvzF CDS" gene complement(2776528..2776713) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /label="yvzF gene" downshifts 2776717 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2776757..2776776) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2776766..2776772 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2776771) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2776786..2776797 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2776789 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2776792..2776795) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2776831..2778279 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" /label="gerAA CDS" gene 2776831..2778279 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /label="gerAA gene" S_feature complement(2777827..2780470) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 2778248..2779345 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" /label="gerAB CDS" gene 2778248..2779345 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /label="gerAB gene" CDS 2779342..2780463 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" /label="gerAC CDS" gene 2779342..2780463 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /label="gerAC gene" CDS complement(2780471..2781106) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" /label="liaR CDS" gene complement(2780471..2781106) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /label="liaR gene" CDS complement(2781084..2782166) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" /label="liaS CDS" gene complement(2781084..2782166) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /label="liaS gene" CDS complement(2782163..2782888) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" /label="liaF CDS" gene complement(2782163..2782888) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /label="liaF gene" CDS complement(2782922..2783794) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" /label="liaG CDS" gene complement(2782922..2783794) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /label="liaG gene" promotor_-10 complement(2783813..2783832) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2783833) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2783847..2783850) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2783895..2784572) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" /label="liaH CDS" gene complement(2783895..2784572) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /label="liaH gene" downshifts complement(2783911) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" /label="downshifts" CDS complement(2784599..2784979) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" /label="liaI CDS" gene complement(2784599..2784979) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /label="liaI gene" promotor_-10 complement(2785002..2785021) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2785022) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2785036..2785039) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2785141..2786409) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" /label="yvqJ CDS" gene complement(2785141..2786409) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /label="yvqJ gene" downshifts complement(2785154) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2786443..2786462) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2786454) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2786477..2786484) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2786580) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2786586..2787167) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" /label="yvqK CDS" gene complement(2786586..2787167) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /label="yvqK gene" CDS complement(2787190..2788518) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" /label="yvrA CDS" gene complement(2787190..2788518) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /label="yvrA gene" CDS complement(2788518..2789579) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" /label="yvrB CDS" gene complement(2788518..2789579) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /label="yvrB gene" CDS complement(2789542..2790486) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" /label="yvrC CDS" gene complement(2789542..2790486) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /label="yvrC gene" S_feature complement(2790487..2790756) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(2790595..2790725) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" /label="srbL RNA" gene complement(2790595..2790725) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /label="srbL gene" promotor_-10 complement(2790733..2790752) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2790756) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2790758..2791685) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(2790768..2790775) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2790818..2790825 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2790840..2790859 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2790844 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="upshifts" CDS 2790884..2791675 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" /label="yvrD CDS" gene 2790884..2791675 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /label="yvrD gene" downshifts 2791546 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 2791656 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2791713..2792591) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" /label="yvrE CDS" gene complement(2791713..2792591) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /label="yvrE gene" downshifts complement(2791730) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2792615..2792633) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2792634) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2792647..2792653) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2792663..2794405) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" /label="yvrG CDS" gene complement(2792663..2794405) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /label="yvrG gene" CDS complement(2794402..2795115) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" /label="yvrH CDS" gene complement(2794402..2795115) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /label="yvrH gene" misc_feature complement(2795146..2795165) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2795164) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="upshifts" CDS complement(2795268..2795507) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" /label="rsoA CDS" gene complement(2795268..2795507) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /label="rsoA gene" downshifts complement(2795275) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2795503..2795521) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2795511..2796041) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" /label="sigO CDS" gene complement(2795511..2796041) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /label="sigO gene" upshifts complement(2795512) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2795536..2795542) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2796044..2796063) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2796051) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" CDS 2796056..2796394 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" /label="yvrJ CDS" gene 2796056..2796394 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /label="yvrJ gene" promotor_-35 complement(2796078..2796085) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2796094..2796113) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2796106) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2796128..2796134) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2796140..2796240 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 2796200 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="upshifts" promotor_no_box 2796368..2796468 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2796428..2796514 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 2796428 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="upshifts" CDS 2796515..2797672 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" /label="oxdC CDS" gene 2796515..2797672 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /label="oxdC gene" downshifts 2797658 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 2797733..2798143 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" /label="rsiO CDS" gene 2797733..2798143 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /label="rsiO gene" downshifts 2798142 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2798177..2799406) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" /label="yvrN CDS" gene complement(2798177..2799406) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /label="yvrN gene" downshifts complement(2798194) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2799399..2800088) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" /label="yvrO CDS" gene complement(2799399..2800088) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /label="yvrO gene" CDS complement(2800072..2801265) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" /label="yvrP CDS" gene complement(2800072..2801265) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /label="yvrP gene" promotor_-10 complement(2801309..2801328) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2801322) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2801343..2801350) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2801436..2802245) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" /label="fhuC CDS" gene complement(2801436..2802245) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /label="fhuC gene" downshifts complement(2801453) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2801592..2801601 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2801614..2801633 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2801618 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2802261..2803271) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" /label="fhuG CDS" gene complement(2802261..2803271) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /label="fhuG gene" CDS complement(2803271..2804425) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" /label="fhuB CDS" gene complement(2803271..2804425) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /label="fhuB gene" promotor_-10 complement(2804358..2804377) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2804375) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2804389..2804396) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2804437..2804444 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2804459..2804478 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2804468 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2804523..2805470 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" /label="fhuD CDS" gene 2804523..2805470 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /label="fhuD gene" downshifts 2805446 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 2805490 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2805644 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(2805705..2807114) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" /label="lysP CDS" gene complement(2805705..2807114) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /label="lysP gene" downshifts complement(2805720) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2806532..2806536 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2806554..2806570 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2806561 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="upshifts" S_feature 2806568..2807535 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(2807216) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" misc_RNA complement(2807218..2807397) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" /label="kswB RNA" gene complement(2807218..2807397) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /label="kswB gene" promotor_-10 complement(2807427..2807444) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2807438) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2807459..2807466) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2807492 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(2807514..2807654) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" /label="sspJ CDS" gene complement(2807514..2807654) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /label="sspJ gene" downshifts complement(2807524) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" upshifts complement(2807682) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="upshifts" S_feature complement(2807684..2808272) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(2807687..2807698) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(2807712..2807718) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 2807744..2807751 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2807765 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2807767..2807786 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2807821..2808303 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" /label="yvsG CDS" gene 2807821..2808303 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /label="yvsG gene" promotor_-35 2808317..2808324 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2808338..2808357 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2808350 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2808403..2810256 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" /label="ltaSP CDS" gene 2808403..2810256 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /label="ltaSP gene" downshifts 2810242 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2810284..2811210) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" /label="yvgK CDS" gene complement(2810284..2811210) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /label="yvgK gene" downshifts complement(2810296) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2811222..2811241) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2811243) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2811257..2811260) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2811279..2811298 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2811288 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="upshifts" CDS 2811321..2812103 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" /label="modA CDS" gene 2811321..2812103 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /label="modA gene" CDS 2812075..2812767 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" /label="modB CDS" gene 2812075..2812767 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /label="modB gene" downshifts 2812759 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" /label="downshifts" CDS complement(2812798..2813628) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" /label="pgoN CDS" gene complement(2812798..2813628) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /label="pgoN gene" downshifts complement(2812804) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2813491..2813495 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2813511..2813515 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2813520 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2813630 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2813658..2813677) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2813676) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2813692..2813699) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2813784..2813790 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2813804 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2813805..2813823 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2813851..2814336 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" /label="yvgO CDS" gene 2813851..2814336 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /label="yvgO gene" downshifts 2814335 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" /label="downshifts" CDS complement(2814380..2816392) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" /label="nhaK CDS" gene complement(2814380..2816392) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /label="nhaK gene" downshifts complement(2814388) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2816058..2816062) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2816060) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2816393..2816544) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(2816521..2816539) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2816544) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2816647..2818362) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" /label="cysI CDS" gene complement(2816647..2818362) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /label="cysI gene" downshifts complement(2816654) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" CDS complement(2818388..2820205) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" /label="cysJ CDS" gene complement(2818388..2820205) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /label="cysJ gene" promotor_-10 complement(2820247..2820266) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2820256..2820263 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2820266) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" upshifts 2820269 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2820276..2820295 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2820279..2820286) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2820376..2822700) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" /label="helD CDS" gene complement(2820376..2822700) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /label="helD gene" downshifts complement(2820394) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2822720..2822727 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2822742..2822761 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2822743..2822758) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2822746 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2822748) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2822793..2822812) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2822802) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2822828..2822834) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2822838..2822857) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2822858) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2822871..2822879) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2822885) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" /label="downshifts" CDS complement(2822898..2823506) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" /label="yvgT CDS" gene complement(2822898..2823506) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /label="yvgT gene" promotor_-10 complement(2823545..2823564) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2823562) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2823580..2823584) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2823693..2824109) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" /label="bdbC CDS" gene complement(2823693..2824109) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /label="bdbC gene" downshifts complement(2823703) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2824114..2824782) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" /label="bdbD CDS" gene complement(2824114..2824782) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /label="bdbD gene" promotor_-10 complement(2824834..2824853) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2824849) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2824860) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2824867..2824872) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2824902..2827010) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" /label="cadA CDS" gene complement(2824902..2827010) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /label="cadA gene" S_feature complement(2827002..2827103) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(2827097..2827116) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2827103) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2827132..2827139) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2827170..2829578) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" /label="copA CDS" gene complement(2827170..2829578) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /label="copA gene" downshifts complement(2827192) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2827258) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2829579..2829661) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(2829662..2829871) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" /label="copZ CDS" gene complement(2829662..2829871) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /label="copZ gene" promotor_-10 complement(2829895..2829914) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(2829916) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="upshifts" promotor_-35 complement(2829927..2829933) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(2829945..2830250) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " /label="csoR CDS" gene complement(2829945..2830250) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /label="csoR gene" misc_feature 2830214..2830233 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2830225 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2830264..2830283) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(2830290) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="upshifts" promotor_-35 complement(2830297..2830303) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 2830342..2830348 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2830363..2830381 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2830371 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2830378..2831454 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" /label="iolW CDS" gene 2830378..2831454 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /label="iolW gene" downshifts 2831441 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2831491..2832126) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" /label="azoRB CDS" gene complement(2831491..2832126) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /label="azoRB gene" downshifts complement(2831504) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2832127..2832224) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(2832204..2832223) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2832224) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2832237..2832243) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2832286..2834181) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" /label="yvaC CDS" gene complement(2832286..2834181) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /label="yvaC gene" promotor_-10 complement(2834232..2834243) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2834232) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2834258..2834264) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2834331) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2834344..2834745) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" /label="yvaD CDS" gene complement(2834344..2834745) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /label="yvaD gene" CDS complement(2834742..2835101) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" /label="yvaE CDS" gene complement(2834742..2835101) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /label="yvaE gene" CDS complement(2835098..2835670) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" /label="yvaF CDS" gene complement(2835098..2835670) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /label="yvaF gene" promotor_-10 complement(2835708..2835727) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2835713) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2835741..2835748) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2835781..2836575) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" /label="yvaG CDS" gene complement(2835781..2836575) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /label="yvaG gene" promotor_-10 complement(2836596..2836614) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2836608) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2836629..2836635) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2836641..2836660) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2836652) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2836654..2836719) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(2836674..2836681) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2836761..2837120) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" /label="ssrA RNA" gene complement(2836761..2837120) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /label="ssrA gene" downshifts complement(2836764) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2837104..2837112) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2837114) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2837127..2837132) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2837172..2837191) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2837180) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2837182..2837246) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(2837204..2837208) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2837246) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="upshifts" promotor_-10 complement(2837247..2837266) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(2837281..2837288) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(2837297..2837767) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" /label="smpB CDS" gene complement(2837297..2837767) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /label="smpB gene" promotor_no_box 2837594..2837694 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2837654 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2837764 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2837812..2837831) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2837818) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" S_feature complement(2837820..2837911) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(2837847..2837850) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(2837912..2840251) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" /label="rnr CDS" gene complement(2837912..2840251) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /label="rnr gene" promotor_-35 2839012..2839015 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2839031..2839034 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2839040 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2840270..2841010) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" /label="estA CDS" gene complement(2840270..2841010) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /label="estA gene" promotor_-10 complement(2840666..2840684) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(2840678) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="upshifts" promotor_-35 complement(2840699..2840705) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(2841038..2841056) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2841052) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="upshifts" downshifts complement(2841140) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" /label="downshifts" CDS complement(2841142..2841372) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" /label="secG CDS" gene complement(2841142..2841372) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /label="secG gene" promotor_-10 complement(2841402..2841421) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2841423) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" promotor_-35 complement(2841436..2841439) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 2841461..2841467 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2841481..2841492 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2841482 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="upshifts" CDS 2841521..2842291 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" /label="yvaM CDS" gene 2841521..2842291 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /label="yvaM gene" promotor_-35 2841543..2841551 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2841562..2841580 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2841592 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2842331..2842564) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" /label="yvzC CDS" gene complement(2842331..2842564) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /label="yvzC gene" promotor_-35 2842655..2842662 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 2842670 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="upshifts" promotor_-10 2842674..2842693 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 2842716..2843123 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" /label="rghRA CDS" gene 2842716..2843123 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /label="rghRA gene" CDS 2843153..2843572 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" /label="rghRB CDS" gene 2843153..2843572 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /label="rghRB gene" promotor_-35 2843610..2843617 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2843631..2843650 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2843638 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2843664..2843990 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" /label="catR CDS" gene 2843664..2843990 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /label="catR gene" S_feature 2843991..2844075 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 2844046..2844053 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2844066..2844084 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2844077 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2844115..2845815 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" /label="yvaQ CDS" gene 2844115..2845815 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /label="yvaQ gene" S_feature complement(2844831..2845824) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 2845793 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2845855..2846535) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" /label="opuBD CDS" gene complement(2845855..2846535) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /label="opuBD gene" downshifts complement(2845869) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2846229..2846235 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2846250..2846268 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2846255..2849006 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 2846255 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2846552..2847472) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" /label="opuBC CDS" gene complement(2846552..2847472) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /label="opuBC gene" CDS complement(2847484..2848137) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " /label="opuBB CDS" gene complement(2847484..2848137) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /label="opuBB gene" CDS complement(2848154..2849299) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" /label="opuBA CDS" gene complement(2848154..2849299) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /label="opuBA gene" S_feature complement(2849300..2849367) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(2849367) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2849368..2849387) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2849398..2849402 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2849402..2849405) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2849418..2849436 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2849423 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2849518..2849522 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2849538..2849557 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2849541 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" CDS 2849583..2850116 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" /label="yvaV CDS" gene 2849583..2850116 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /label="yvaV gene" S_feature complement(2849783..>2850182) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 2850105 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2850182,2850189) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs14" N_region 2850183..2850188 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs14" S_feature <2850189..2850264 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" S_feature complement(<2850189..2850255) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" CDS complement(2850260..2850949) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" /label="opuCD CDS" gene complement(2850260..2850949) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /label="opuCD gene" downshifts complement(2850300) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" promotor_-35 2850892..2850900 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2850914..2850933 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2850928 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2850967..2851878) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" /label="opuCC CDS" gene complement(2850967..2851878) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /label="opuCC gene" CDS complement(2851898..2852551) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " /label="opuCB CDS" gene complement(2851898..2852551) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /label="opuCB gene" CDS complement(2852574..2853716) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" /label="opuCA CDS" gene complement(2852574..2853716) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /label="opuCA gene" promotor_-10 complement(2853760..2853779) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(2853775) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="upshifts" promotor_-35 complement(2853794..2853797) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 2853913..2853920 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2853933..2853952 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2853944 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="upshifts" CDS 2853980..2854537 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" /label="opcR CDS" gene 2853980..2854537 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /label="opcR gene" S_feature 2854538..2855302 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(2854555..2855190) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" /label="yvbG CDS" gene complement(2854555..2855190) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /label="yvbG gene" downshifts complement(2854568) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2855231..2855249) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2855237) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2855265..2855271) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2855276..2855283 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2855295..2855314 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2855304 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2855340..2855954 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" /label="yvbH CDS" gene 2855340..2855954 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /label="yvbH gene" downshifts 2855940 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 2856008..2856011 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2856026..2856045 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2856034 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2856086..2856784 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" /label="yvbI CDS" gene 2856086..2856784 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /label="yvbI gene" downshifts 2856757 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2856820..2858637) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" /label="yvbJ CDS" gene complement(2856820..2858637) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /label="yvbJ gene" downshifts complement(2856839) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2857010) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" misc_feature complement(2858679..2858698) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 2858683..2858702 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2858688 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2858692) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2858757..2859224 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" /label="yvbK CDS" gene 2858757..2859224 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /label="yvbK gene" downshifts 2859221 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2859269..2860561) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" /label="eno CDS" gene complement(2859269..2860561) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /label="eno gene" downshifts complement(2859279) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2860591..2862126) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" /label="pgm CDS" gene complement(2860591..2862126) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /label="pgm gene" CDS complement(2862119..2862880) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" /label="tpiA CDS" gene complement(2862119..2862880) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /label="tpiA gene" CDS complement(2862911..2864095) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" /label="pgk CDS" gene complement(2862911..2864095) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /label="pgk gene" S_feature complement(2864096..2864336) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(2864336) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2864338..2864411) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(2864350..2864369) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2864385..2864389) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2864412..2865419) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" /label="gapA CDS" gene complement(2864412..2865419) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /label="gapA gene" promotor_-35 2865338..2865341 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2865358..2865360 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2865360 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2865466..2866488) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" /label="cggR CDS" gene complement(2865466..2866488) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /label="cggR gene" upshifts complement(2865482) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2865510..2865511) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2866489..2866600) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 2866526 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2866581..2866600) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2866600) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2866602..2866712) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(2866614..2866621) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2866695..2866714) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(2866710) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="upshifts" promotor_-35 complement(2866727..2866736) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(2866786..2868180) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" /label="araE CDS" gene complement(2866786..2868180) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /label="araE gene" downshifts complement(2866800) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2868279..2868298) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2868293) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2868313..2868320) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2868320..2868327 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2868341..2868360 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2868347 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="upshifts" CDS 2868384..2869472 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" /label="araR CDS" gene 2868384..2869472 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /label="araR gene" downshifts 2869452 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2869521..2870531) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" /label="yvbT CDS" gene complement(2869521..2870531) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /label="yvbT gene" downshifts complement(2869528) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2870532..2870609) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(2870599..2870618) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2870609) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2870632..2870639) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2870688..2871566) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" /label="yvbU CDS" gene complement(2870688..2871566) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /label="yvbU gene" promotor_-35 2871224..2871230 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2871245..2871256 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2871256 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2871600..2871607 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2871613..2871632) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(2871618) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="upshifts" promotor_-10 2871621..2871640 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2871623 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2871646..2871650) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 2871666..2872583 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" /label="cyeB CDS" gene 2871666..2872583 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /label="cyeB gene" downshifts 2872572 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2872624..2873967) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" /label="yvbW CDS" gene complement(2872624..2873967) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /label="yvbW gene" misc_RNA complement(2874036..2874271) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" /label="tboX RNA" gene complement(2874036..2874271) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /label="tboX gene" downshifts complement(2874170) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2874272..2874368) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(2874369..2875403) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" /label="yvbX CDS" gene complement(2874369..2875403) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /label="yvbX gene" promotor_-10 complement(2875425..2875443) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2875431) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2875456..2875463) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2875511..2876233) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" /label="lutC CDS" gene complement(2875511..2876233) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /label="lutC gene" downshifts complement(2875527) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" /label="downshifts" CDS complement(2876233..2877672) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" /label="lutB CDS" gene complement(2876233..2877672) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /label="lutB gene" promotor_-35 2877220..2877223 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2877240 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2877241..2877245 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2877394 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 2877548 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2877549..2877550 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2877699..2878415) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" /label="lutA CDS" gene complement(2877699..2878415) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /label="lutA gene" promotor_-35 2878319..2878326 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2878340..2878342 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2878340 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2878413 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" S_feature complement(2878416..2878482) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(2878479..2878498) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(2878482) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="upshifts" promotor_-35 complement(2878513..2878520) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(2878590..2879192) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" /label="yvfU CDS" gene complement(2878590..2879192) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /label="yvfU gene" CDS complement(2879209..2880324) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" /label="yvfT CDS" gene complement(2879209..2880324) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /label="yvfT gene" CDS complement(2880328..2881065) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" /label="yvfS CDS" gene complement(2880328..2881065) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /label="yvfS gene" promotor_-10 complement(2880354..2880373) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(2880368) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="upshifts" promotor_-35 complement(2880385..2880392) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(2881066..2881971) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" /label="yvfR CDS" gene complement(2881066..2881971) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /label="yvfR gene" promotor_-10 complement(2881991..2882009) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2882002) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2882025..2882028) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2882180..2882187 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2882198..2882217 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2882205 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="upshifts" CDS 2882255..2883064 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" /label="rsbQ CDS" gene 2882255..2883064 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /label="rsbQ gene" CDS 2883100..2884311 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" /label="rsbP CDS" gene 2883100..2884311 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /label="rsbP gene" downshifts 2884298 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2884365..2885654) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" /label="ganB CDS" gene complement(2884365..2885654) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /label="ganB gene" CDS complement(2885734..2887797) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" /label="ganA CDS" gene complement(2885734..2887797) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /label="ganA gene" CDS complement(2887816..2888667) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" /label="ganQ CDS" gene complement(2887816..2888667) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /label="ganQ gene" CDS complement(2888671..2889927) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" /label="ganP CDS" gene complement(2888671..2889927) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /label="ganP gene" CDS complement(2889967..2891232) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" /label="ganS CDS" gene complement(2889967..2891232) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /label="ganS gene" promotor_-10 complement(2891264..2891283) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2891286) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2891298..2891305) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2891373..2892365) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" /label="ganR CDS" gene complement(2891373..2892365) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /label="ganR gene" downshifts complement(2891407) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" /label="downshifts" S_feature complement(2892495..2892544) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(2892518) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2892545..2893204) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" /label="lutR CDS" gene complement(2892545..2893204) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /label="lutR gene" S_feature complement(2893205..2893310) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(2893302..2893321) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2893311) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2893336..2893339) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2893363..2893370 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2893385..2893404 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2893385 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="upshifts" S_feature 2893388..2893493 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(2893394..2893411) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2893398) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2893419..2893425) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2893494..2895185 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" /label="lutP CDS" gene 2893494..2895185 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /label="lutP gene" downshifts 2895170 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2895212..2896522) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" /label="sigL CDS" gene complement(2895212..2896522) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /label="sigL gene" S_feature 2895215..2896285 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(2895224) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2896342..2896361 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2896342..2896600 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 2896342 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2896536..2896555) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2896551) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2896570..2896573) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2896601..2896819 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" /label="yvfG CDS" gene 2896601..2896819 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /label="yvfG gene" downshifts 2896798 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" SCAR join(2896826,2896833) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs26" N_region 2896827..2896832 /note="EcoR site (GAATTC)" /created_by="User" /modified_by="User" /label="IIG_Bs26" promotor_-35 2896864..2896867 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2896873 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2896884..2896902 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2896918..2898387 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" /label="pnbA CDS" gene 2896918..2898387 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /label="pnbA gene" downshifts 2898364 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS 2898390..2898581 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" /label="hypothetical protein CDS" gene 2898390..2898581 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /label="gene" downshifts 2898560 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2898608..2899093) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" /label="padC CDS" gene complement(2898608..2899093) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /label="padC gene" CDS complement(2899116..2899427) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" /label="yveG CDS" gene complement(2899116..2899427) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo /label="yveG gene" CDS complement(2899479..2899571) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" /label="yveF CDS" gene complement(2899479..2899571) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo /label="yveF gene" promotor_-10 complement(2899611..2899630) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2899628) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2899644..2899651) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2899702..2900385) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" /label="racX CDS" gene complement(2899702..2900385) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /label="racX gene" downshifts complement(2899720) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" /label="downshifts" CDS complement(2900401..2901756) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" /label="pbpE CDS" gene complement(2900401..2901756) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /label="pbpE gene" promotor_-10 complement(2901768..2901783) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2901784) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2901795..2901804) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2902058..2902065 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2902079..2902098 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2902082 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="upshifts" S_feature 2902104..2902294 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 2902295..2903716 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" /label="sacB CDS" gene 2902295..2903716 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /label="sacB gene" downshifts 2903710 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2903790..2905340 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" /label="levB CDS" gene 2903790..2905340 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /label="levB gene" promotor_-35 2905384..2905390 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2905404..2905415 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2905404 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="upshifts" CDS 2905448..2907010 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" /label="aspP CDS" gene 2905448..2907010 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /label="aspP gene" downshifts 2906988 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2907000..2907689 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" /label="yvdT CDS" gene 2907000..2907689 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /label="yvdT gene" promotor_-35 2907039..2907046 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2907060..2907079 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2907069 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="upshifts" downshifts 2907670 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(2907768) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS 2907771..2908106 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" /label="psmA CDS" gene 2907771..2908106 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /label="psmA gene" CDS 2908106..2908426 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" /label="psmB CDS" gene 2908106..2908426 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /label="psmB gene" S_feature 2908427..2908617 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(2908462..2908974) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" /label="yvdQ CDS" gene complement(2908462..2908974) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /label="yvdQ gene" downshifts 2908594 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2909010..2909021) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2909016) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2909036..2909042) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2909089..2909225) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(2909132) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" CDS complement(2909226..2910569) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" /label="cotNP CDS" gene complement(2909226..2910569) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /label="cotNP gene" promotor_-10 complement(2910598..2910617) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2910606) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2910630..2910639) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2910631..2910636 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2910652..2910670 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2910655 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2910864..2910873 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2910882 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2910887..2910906 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2910925..2911887 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" /label="cotR CDS" gene 2910925..2911887 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /label="cotR gene" S_feature 2911888..2912141 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(2912168) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" tRNA complement(2912172..2912247) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnQ-Arg tRNA" gene complement(2912172..2912247) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /label="trnQ-Arg gene" promotor_-10 complement(2912274..2912293) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2912295) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2912309..2912312) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2912378..2912384 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2912394..2912469 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 2912394 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2912399..2912418 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2912446..2912453 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2912467..2912486 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2912471 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="upshifts" CDS 2912517..2913110 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" /label="clpP CDS" gene 2912517..2913110 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /label="clpP gene" downshifts 2913099 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 2913144..2913542 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(2913156..2913836) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" /label="mdxM CDS" gene complement(2913156..2913836) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /label="mdxM gene" downshifts complement(2913180) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" CDS complement(2913833..2915518) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" /label="mdxL CDS" gene complement(2913833..2915518) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /label="mdxL gene" CDS complement(2915511..2917784) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" /label="mdxK CDS" gene complement(2915511..2917784) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /label="mdxK gene" CDS complement(2917762..2918646) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" /label="mdxJ CDS" gene complement(2917762..2918646) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /label="mdxJ gene" CDS complement(2918652..2919488) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" /label="mdxG CDS" gene complement(2918652..2919488) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /label="mdxG gene" CDS complement(2919489..2920796) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" /label="mdxF CDS" gene complement(2919489..2920796) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /label="mdxF gene" promotor_-35 2919854..2919863 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2919876..2919895 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2919880 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2920836..2922089) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" /label="mdxE CDS" gene complement(2920836..2922089) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /label="mdxE gene" S_feature complement(2922090..2922184) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(2922185..2923954) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" /label="mdxD CDS" gene complement(2922185..2923954) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /label="mdxD gene" promotor_-35 2923875..2923880 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2923896..2923914 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2923906 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2923992..2924011) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2924005) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2924024..2924031) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2924067..2925017) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" /label="mdxR CDS" gene complement(2924067..2925017) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /label="mdxR gene" promotor_-10 complement(2925032..2925050) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2925045) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2925062..2925070) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2925151) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2925223..2925798) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" /label="yvdD CDS" gene complement(2925223..2925798) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /label="yvdD gene" downshifts complement(2925235) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2925841..2925860) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2925847..2925854 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2925857) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="upshifts" upshifts 2925864 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2925867..2925886 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2925875..2925882) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2925915..2926235 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" /label="yvdC CDS" gene 2925915..2926235 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /label="yvdC gene" downshifts 2926216 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2926262) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2926262..2927854) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" /label="yvdB CDS" gene complement(2926262..2927854) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /label="yvdB gene" CDS complement(2927873..2928466) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" /label="yvdA CDS" gene complement(2927873..2928466) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /label="yvdA gene" promotor_-10 complement(2928508..2928527) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2928521) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2928542..2928546) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2928592..2928597 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2928613..2928631 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2928614 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2928787..2928794 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2928808..2928827 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2928812 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" CDS 2928849..2929826 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" /label="yvcT CDS" gene 2928849..2929826 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /label="yvcT gene" downshifts 2929798 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2929864..2931804) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" /label="psdB CDS" gene complement(2929864..2931804) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /label="psdB gene" downshifts complement(2929888) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" /label="downshifts" CDS complement(2931779..2932558) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" /label="psdA CDS" gene complement(2931779..2932558) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /label="psdA gene" S_feature complement(2932559..2932640) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(2932641..2933711) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" /label="psdS CDS" gene complement(2932641..2933711) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /label="psdS gene" CDS complement(2933705..2934418) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" /label="psdR CDS" gene complement(2933705..2934418) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /label="psdR gene" promotor_-10 complement(2934464..2934483) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2934476) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2934478..2934739) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(2934496..2934499) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2934499..2934506 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2934517..2934536 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2934522 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2934565..2934774 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" /label="yvzJ CDS" gene 2934565..2934774 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /label="yvzJ gene" downshifts 2934752 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2934784) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2934810..2935574) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" /label="yvcN CDS" gene complement(2934810..2935574) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /label="yvcN gene" downshifts complement(2934832) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2935575..2935832) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" /label="crh CDS" gene complement(2935575..2935832) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /label="crh gene" CDS complement(2935856..2936806) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" /label="whiA CDS" gene complement(2935856..2936806) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /label="whiA gene" CDS complement(2936829..2937782) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" /label="mgfK CDS" gene complement(2936829..2937782) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /label="mgfK gene" CDS complement(2937784..2938671) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" /label="yvcJ CDS" gene complement(2937784..2938671) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /label="yvcJ gene" CDS complement(2938696..2939172) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" /label="yvcI CDS" gene complement(2938696..2939172) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /label="yvcI gene" promotor_-10 complement(2939192..2939211) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2939206) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2939227..2939231) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2939250..2939269) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2939263) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2939284..2939287) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2939339..2939489) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(2939382) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" /label="downshifts" CDS complement(2939490..2940440) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" /label="trxB CDS" gene complement(2939490..2940440) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /label="trxB gene" S_feature complement(2940441..2940528) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(2940517..2940536) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2940528) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2940530..2940621) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(2940551..2940554) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2940569..2940575 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2940589..2940607 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2940603 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="upshifts" S_feature 2940604..2943990 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(2940646..2942067) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" /label="cwlO CDS" gene complement(2940646..2942067) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /label="cwlO gene" downshifts complement(2940666) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" /label="downshifts" downshifts complement(2940790) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" misc_feature 2941694..2941698 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2941704 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2941983..2941987 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2941990 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2942068..2942265) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 2942188 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2942253..2942272) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(2942265) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" promotor_-35 complement(2942284..2942291) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(2942448..2943902) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" /label="yvcD CDS" gene complement(2942448..2943902) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /label="yvcD gene" downshifts complement(2942468) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" S_feature complement(2943903..2944027) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 2943948 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2944028..2945797) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" /label="bmrA CDS" gene complement(2944028..2945797) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /label="bmrA gene" S_feature complement(2945798..2945872) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(2945861..2945880) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2945872) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" CDS complement(2945962..2946321) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" /label="yvzA CDS" gene complement(2945962..2946321) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /label="yvzA gene" downshifts complement(2945982) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2946336..2948246) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" /label="yvcB CDS" gene complement(2946336..2948246) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /label="yvcB gene" CDS complement(2948248..2948790) /gene="yvcA" /locus_tag="PG10_pseudo_BSU_34850" /old_locus_tag="BSU_34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /modified_by="User" /translation="MVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGKNKE SIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKKTDI YTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDEEKA KNKVEKLINSITFLIDKKEK*" /label="PG10_pseudo_BSU_34850" gene complement(2948248..2948790) /gene="yvcA" /locus_tag="PG10_pseudo_BSU_34850" /old_locus_tag="BSU_34850" /modified_by="User" /label="PG10_pseudo_BSU_34850" N_region 2948849..2949898 /comment="Inserted sequence is a combination of three independent chromosomal regions. First the arabinose inducible mtlA promoter, second a copy of the original comK gene as well as third a copy of the original comS gene." /modified_by="User" /label="IIG_Bs27_024" promotor_-35 2948909..2948916 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2948930..2948949 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2948935 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" CDS 2949009..2949587 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 2949009..2949587 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" CDS 2949636..2949776 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 2949636..2949776 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" S_feature complement(<2949899..2949940) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" CDS complement(2949966..2950595) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" /label="hisIE CDS" gene complement(2949966..2950595) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /label="hisIE gene" downshifts complement(2949985) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" /label="downshifts" CDS complement(2950592..2951350) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" /label="hisF CDS" gene complement(2950592..2951350) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /label="hisF gene" CDS complement(2951347..2952084) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" /label="hisA CDS" gene complement(2951347..2952084) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /label="hisA gene" CDS complement(2952081..2952719) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" /label="hisH CDS" gene complement(2952081..2952719) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /label="hisH gene" promotor_no_box 2952577..2952677 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2952637 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2952720..2953304) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" /label="hisB CDS" gene complement(2952720..2953304) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /label="hisB gene" CDS complement(2953301..2954584) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" /label="hisD CDS" gene complement(2953301..2954584) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /label="hisD gene" CDS complement(2954581..2955222) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" /label="hisG CDS" gene complement(2954581..2955222) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /label="hisG gene" CDS complement(2955215..2956390) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " /label="hisZ CDS" gene complement(2955215..2956390) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /label="hisZ gene" S_feature complement(2956391..2956468) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 2956434..2956440 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2956452..2956471 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2956452..2956471) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2956465 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2956468) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2956484..2956491) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2956600..2956619 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2956607 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="upshifts" CDS 2956641..2957393 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" /label="yvpB CDS" gene 2956641..2957393 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /label="yvpB gene" S_feature 2957394..2957632 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(2957415..2957426) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2957421) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2957441..2957447) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2957633..2958298 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" /label="pelC CDS" gene 2957633..2958298 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /label="pelC gene" downshifts 2958269 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(2958318..2958836) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" /label="hprF CDS" gene complement(2958318..2958836) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /label="hprF gene" downshifts complement(2958352) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2958840..2959490) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" /label="ppaX CDS" gene complement(2958840..2959490) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /label="ppaX gene" CDS complement(2959487..2960425) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" /label="yvoD CDS" gene complement(2959487..2960425) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /label="yvoD gene" CDS complement(2960449..2961258) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" /label="lgt CDS" gene complement(2960449..2961258) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /label="lgt gene" CDS complement(2961272..2962204) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" /label="hprK CDS" gene complement(2961272..2962204) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /label="hprK gene" promotor_-10 complement(2962246..2962265) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2962252) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2962281..2962286) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2962321..2962328 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2962340 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2962343..2962360 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2962386..2963576 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" /label="nagA CDS" gene 2962386..2963576 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /label="nagA gene" promotor_-35 2963374..2963380 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2963395 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2963396..2963414 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2963573..2964301 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" /label="nagBA CDS" gene 2963573..2964301 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /label="nagBA gene" CDS 2964319..2965050 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" /label="nagR CDS" gene 2964319..2965050 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /label="nagR gene" CDS complement(2965070..2968939) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" /label="yvnB CDS" gene complement(2965070..2968939) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /label="yvnB gene" downshifts complement(2965192) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2968959..2968970) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2968966) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2968985..2968991) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2969029..2969035 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2969049..2969068 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2969054 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="upshifts" CDS 2969104..2969577 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" /label="yvnA CDS" gene 2969104..2969577 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /label="yvnA gene" S_feature 2969578..2969685 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(2969618..2970835) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" /label="cypX CDS" gene complement(2969618..2970835) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /label="cypX gene" downshifts complement(2969631) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2969657..2969662 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2969677..2969688 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2969687..2969972 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 2969687 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="upshifts" downshifts 2969929 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(2970851..2971597) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" /label="pchC CDS" gene complement(2970851..2971597) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /label="pchC gene" S_feature complement(2971598..2971784) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(2971770..2971789) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2971784) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2971803..2971810) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2971918..2971925 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2971940..2971959 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2971952 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="upshifts" S_feature 2971953..2972022 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 2972023..2972532 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" /label="pchR CDS" gene 2972023..2972532 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /label="pchR gene" S_feature complement(2972428..2973766) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(2972469) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2972553..2973764 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" /label="pchE CDS" gene 2972553..2973764 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /label="pchE gene" downshifts 2973762 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" /label="downshifts" CDS complement(2973792..2974151) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" /label="yvlD CDS" gene complement(2973792..2974151) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /label="yvlD gene" S_feature 2973807..2974523 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(2973811) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2974153..2974350) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" /label="yvlC CDS" gene complement(2974153..2974350) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /label="yvlC gene" CDS complement(2974355..2975452) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" /label="yvlB CDS" gene complement(2974355..2975452) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /label="yvlB gene" CDS complement(2975477..2975803) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" /label="yvlA CDS" gene complement(2975477..2975803) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /label="yvlA gene" promotor_-10 complement(2975856..2975871) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2975871) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2975873..2976363) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(2975883..2975892) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2975951..2975954 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2975969..2975988 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2975979 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="upshifts" CDS 2976021..2976251 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" /label="yvkN CDS" gene 2976021..2976251 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /label="yvkN gene" promotor_-10 complement(2976354..2976373) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(2976364) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="upshifts" promotor_-35 complement(2976389..2976393) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(2976450..2976932) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" /label="yvzB CDS" gene complement(2976450..2976932) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo /label="yvzB gene" downshifts 2976458 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" /label="downshifts" downshifts complement(2976473) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2976605) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2976613..2976616) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2976693..2976697) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2976693) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2976713..2976716) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2976933..2977066) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(2977094..2979967) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" /label="uvrA CDS" gene complement(2977094..2979967) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /label="uvrA gene" downshifts complement(2977111) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2979975..2981960) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" /label="uvrB CDS" gene complement(2979975..2981960) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /label="uvrB gene" promotor_-10 complement(2981994..2982013) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2982006) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2982008..2982093) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(2982025..2982032) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2982138) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" /label="downshifts" CDS complement(2982146..2982376) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" /label="csbA CDS" gene complement(2982146..2982376) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /label="csbA gene" promotor_-10 complement(2982403..2982422) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(2982413) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="upshifts" S_feature complement(2982415..2982479) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(2982436..2982443) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(2982456..2982474) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2982477) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2982489..2982495) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2982545) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(2982571..2982671) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2982611) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2982693..2982700 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2982714..2982733 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2982731 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2982823..2985318 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" /label="yvkC CDS" gene 2982823..2985318 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /label="yvkC gene" misc_feature 2985333..2985337 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2985351 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="upshifts" CDS 2985394..2985963 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" /label="yvkB CDS" gene 2985394..2985963 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /label="yvkB gene" CDS 2985994..2987328 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" /label="yvkA CDS" gene 2985994..2987328 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /label="yvkA gene" downshifts 2987309 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" /label="downshifts" CDS complement(2987376..2988569) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" /label="minJ CDS" gene complement(2987376..2988569) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /label="minJ gene" downshifts complement(2987385) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" /label="downshifts" downshifts complement(2987450) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2988570..2988647) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(2988573) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2988648..2988986) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" /label="swrAAc CDS" gene complement(2988648..2988986) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo /label="swrAAc gene" CDS complement(2988961..2989077) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" /label="swrAAn CDS" gene complement(2988961..2989077) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo /label="swrAAn gene" S_feature complement(2989078..2989167) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(2989149..2989167) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2989167) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2989169..2989249) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(2989181..2989186) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2989235..2989253) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2989249) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2989267..2989274) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2989386..2990828) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" /label="ctpB CDS" gene complement(2989386..2990828) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /label="ctpB gene" downshifts complement(2989475) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2990874..2990885) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2990885) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2990900..2990906) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2990968..2991858) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" /label="ftsX CDS" gene complement(2990968..2991858) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /label="ftsX gene" downshifts complement(2990985) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" /label="downshifts" CDS complement(2991851..2992537) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" /label="ftsE CDS" gene complement(2991851..2992537) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /label="ftsE gene" S_feature complement(2992538..2992670) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(2992660..2992679) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2992670) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2992694..2992697) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2992771..2993109) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" /label="cccB CDS" gene complement(2992771..2993109) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /label="cccB gene" downshifts complement(2992772) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2993136..2993155) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(2993149) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" CDS complement(2993158..2994042) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" /label="yvjA CDS" gene complement(2993158..2994042) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /label="yvjA gene" promotor_-35 complement(2993169..2993176) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(2994030..2994049) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(2994051) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" promotor_-35 complement(2994064..2994071) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(2995199..2995270), complement(2994169..2995197)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" /label="prfB CDS" gene complement(2994169..2995270) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /label="prfB gene" downshifts complement(2994185) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(2995271..2995339) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(2995340..2997865) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" /label="secA CDS" gene complement(2995340..2997865) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /label="secA gene" S_feature complement(2997866..2997946) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(2997936..2997955) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2997946) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2998033..2998602) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" /label="hpf CDS" gene complement(2998033..2998602) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /label="hpf gene" downshifts complement(2998041) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 2998569..2998575 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2998588..2998607 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2998595 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2998629..2998647) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2998637) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2998639..>2998740) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(2998659..2998667) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 2998740..2998741 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_008" CDS complement(2998744..2999226) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" /label="flgN CDS" gene complement(2998744..2999226) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /label="flgN gene" CDS complement(2999242..2999508) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" /label="flgM CDS" gene complement(2999242..2999508) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /label="flgM gene" S_feature complement(2999509..2999588) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(2999589..3000008) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" /label="yvyF CDS" gene complement(2999589..3000008) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /label="yvyF gene" promotor_-10 complement(3000047..3000065) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3000058) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3000079..3000086) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3000082..3000804) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" /label="comFC CDS" gene complement(3000082..3000804) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /label="comFC gene" CDS complement(3000768..3001064) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" /label="comFB CDS" gene complement(3000768..3001064) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /label="comFB gene" promotor_-10 complement(3001090..3001109) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3001103) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3001120..3001127) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3001124..3002515) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" /label="comFA CDS" gene complement(3001124..3002515) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /label="comFA gene" promotor_-10 complement(3002529..3002548) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3002544) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3002562..3002569) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3002621..3003466) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" /label="fakBA CDS" gene complement(3002621..3003466) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /label="fakBA gene" downshifts complement(3002632) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3002883..3002890 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3002904..3002923 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3002914..3004646 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 3002914 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3003493..3003512) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3003512) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3003527..3003530) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3003564..3004253) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" /label="degU CDS" gene complement(3003564..3004253) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /label="degU gene" downshifts complement(3003578) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature complement(3004254..3004335) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(3004336..3005493) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" /label="degS CDS" gene complement(3004336..3005493) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /label="degS gene" S_feature complement(3005494..3005621) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 3005541..3005544 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3005559..3005578 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3005570..3005656 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 3005570 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3005615..3005634) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3005621) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3005638..3005646 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3005645..3005652) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3005658 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3005660..3005668 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3005710..3006363 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " /label="yvyE CDS" gene 3005710..3006363 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /label="yvyE gene" S_feature complement(3006066..3006658) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 3006363..3007538 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " /label="tagV CDS" gene 3006363..3007538 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /label="tagV gene" promotor_-10 complement(3006654..3006672) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3006663) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3006686..3006692) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3007510 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(3007611..3008687) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" /label="tagO CDS" gene complement(3007611..3008687) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /label="tagO gene" downshifts complement(3007627) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 3007673..3007682 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3007696..3007715 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3007704..3008937 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 3007704 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3008688..3008770) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(3008758..3008777) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3008770) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3008789..3008795) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3008832..3010025) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" /label="tuaH CDS" gene complement(3008832..3010025) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /label="tuaH gene" downshifts complement(3008862) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" /label="downshifts" CDS complement(3010054..3010812) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" /label="tuaG CDS" gene complement(3010054..3010812) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /label="tuaG gene" CDS complement(3010836..3011516) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" /label="tuaF CDS" gene complement(3010836..3011516) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /label="tuaF gene" CDS complement(3011545..3013011) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" /label="tuaE CDS" gene complement(3011545..3013011) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /label="tuaE gene" S_feature complement(3013012..3013095) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(3013096..3014481) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" /label="tuaD CDS" gene complement(3013096..3014481) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /label="tuaD gene" CDS complement(3014543..3015712) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" /label="tuaC CDS" gene complement(3014543..3015712) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /label="tuaC gene" CDS complement(3015709..3017160) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" /label="tuaB CDS" gene complement(3015709..3017160) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /label="tuaB gene" CDS complement(3017216..3017365) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" /label="tuaAc CDS" gene complement(3017216..3017365) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo /label="tuaAc gene" CDS complement(3017310..3017849) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" /label="tuaAn CDS" gene complement(3017310..3017849) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo /label="tuaAn gene" misc_feature complement(3017905..3017922) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3017909) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3018076..3019566) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" /label="lytC CDS" gene complement(3018076..3019566) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /label="lytC gene" downshifts complement(3018098) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3019605..3021722) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" /label="lytB CDS" gene complement(3019605..3021722) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /label="lytB gene" CDS complement(3021746..3022054) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" /label="lytA CDS" gene complement(3021746..3022054) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /label="lytA gene" downshifts 3021960 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 3022050..3022054 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3022063..3022077 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3022064..3022082) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3022070 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3022096..3022103) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3022099) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3022120..3022128 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3022142..3022155 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3022160 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="upshifts" CDS 3022238..3023158 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" /label="tagU CDS" gene 3022238..3023158 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /label="tagU gene" downshifts 3023148 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3023198..3024340) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" /label="mnaA CDS" gene complement(3023198..3024340) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /label="mnaA gene" downshifts complement(3023222) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3024379..3024398) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3024393) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3024413..3024416) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3024469..3024473 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3024489..3024508 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3024490..3024585 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 3024491 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="upshifts" CDS 3024586..3025464 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" /label="gtaB CDS" gene 3024586..3025464 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /label="gtaB gene" S_feature 3025465..3026556 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(3025534..3025889) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 3025798..3026016 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" /label="hypothetical protein CDS" gene 3025798..3026016 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /label="gene" CDS complement(3025890..3025973) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" /label="yvzH CDS" gene complement(3025890..3025973) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo /label="yvzH gene" S_feature complement(3025974..3026165) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(3026166..3028868) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" /label="ggaB CDS" gene complement(3026166..3028868) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /label="ggaB gene" S_feature complement(3028869..3028991) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 3028890..3028896 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3028911..3028929 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3028916..3031748 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 3028916 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3028992..3030332) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" /label="ggaA CDS" gene complement(3028992..3030332) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo /label="ggaA gene" CDS complement(3030373..3030579) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" /label="yvzI CDS" gene complement(3030373..3030579) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo /label="yvzI gene" S_feature complement(3030580..3031453) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(3031447..3031466) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3031453) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3031455..3031694) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(3031479..3031485) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3031676..3031694) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(3031694) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="upshifts" promotor_-35 complement(3031708..3031715) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 3031717..3031724 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3031736..3031755 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3031750..3031880 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 3031750 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3031822..3031922 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3031882 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS 3031886..3032482 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" /label="yvzE CDS" gene 3031886..3032482 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo /label="yvzE gene" downshifts 3032080 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3032521..3034104) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" /label="tagH CDS" gene complement(3032521..3034104) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /label="tagH gene" downshifts 3032564 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" /label="downshifts" CDS complement(3034124..3034951) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " /label="tagG CDS" gene complement(3034124..3034951) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /label="tagG gene" S_feature complement(3034952..3035016) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(3035012..3035031) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3035016) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3035018..3035115) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(3035047..3035050) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3035116..3037356) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" /label="tagF CDS" gene complement(3035116..3037356) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /label="tagF gene" CDS complement(3037356..3039377) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" /label="tagE CDS" gene complement(3037356..3039377) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /label="tagE gene" promotor_-35 3038119..3038128 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3038141..3038156 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3038152 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3039378..3039537) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(3039538..3039927) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" /label="tagD CDS" gene complement(3039538..3039927) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /label="tagD gene" S_feature complement(3039928..3040062) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(3040046..3040065) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3040062) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3040076..3040083) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3040217..3040223 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3040234..3040326 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 3040234 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3040235..3040254 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3040327..3041097 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" /label="tagA CDS" gene 3040327..3041097 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /label="tagA gene" S_feature complement(3040454..3040802) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(3040806..3040817) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3040810) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3040832..3040838) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3041122 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS 3041130..3042275 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" /label="tagB CDS" gene 3041130..3042275 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /label="tagB gene" downshifts 3042263 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" /label="downshifts" promotor_-35 3042317..3042324 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3042339..3042358 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3042349 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="upshifts" CDS 3042395..3043723 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" /label="tagC CDS" gene 3042395..3043723 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /label="tagC gene" downshifts 3043718 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3043779) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" SCAR 3043803..3043804 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_002" downshifts 3043827 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3043880..3045121) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" /label="pgdS CDS" gene complement(3043880..3045121) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /label="pgdS gene" downshifts complement(3043899) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3045143..3045161) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3045165) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3045174..3045181) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3045262..3045429) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" /label="edmS CDS" gene complement(3045262..3045429) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /label="edmS gene" downshifts complement(3045289) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" CDS complement(3045444..3046586) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" /label="capA CDS" gene complement(3045444..3046586) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /label="capA gene" CDS complement(3046605..3047054) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" /label="capC CDS" gene complement(3046605..3047054) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /label="capC gene" promotor_-35 3046748..3046754 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 3046762 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="upshifts" promotor_-10 3046768..3046786 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 3046775..3048984 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(3047069..3048250) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" /label="capB CDS" gene complement(3047069..3048250) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /label="capB gene" promotor_-35 3048964..3048971 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3048986 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3048987..3049006 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3049007) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3049012..3049026) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3049034..3049038) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3049034..3050014 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" /label="rbsR CDS" gene 3049034..3050014 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /label="rbsR gene" promotor_-35 3049863..3049870 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3049884..3049903 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3049899 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" CDS 3050016..3050897 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" /label="rbsK CDS" gene 3050016..3050897 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /label="rbsK gene" CDS 3050894..3051289 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" /label="rbsD CDS" gene 3050894..3051289 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /label="rbsD gene" CDS 3051305..3052786 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" /label="rbsA CDS" gene 3051305..3052786 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /label="rbsA gene" CDS 3052788..3053756 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" /label="rbsC CDS" gene 3052788..3053756 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /label="rbsC gene" CDS 3053768..3054685 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" /label="rbsB CDS" gene 3053768..3054685 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /label="rbsB gene" promotor_-35 3054694..3054700 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3054715..3054733 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3054717 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="upshifts" CDS 3054767..3055303 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" /label="ywsB CDS" gene 3054767..3055303 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /label="ywsB gene" downshifts 3055286 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature 3055331..3055441 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 3055410..3055416 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3055431..3055442 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3055443 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3055459..3055755 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" /label="ywsA CDS" gene 3055459..3055755 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /label="ywsA gene" S_feature 3055756..3056408 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(3055795..3056322) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" /label="ywrO CDS" gene complement(3055795..3056322) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /label="ywrO gene" downshifts complement(3055805) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3056342..3056361) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3056355) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="upshifts" downshifts 3056366 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3056375..3056382) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3056421) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3056422..3057189) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" /label="alsD CDS" gene complement(3056422..3057189) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /label="alsD gene" CDS complement(3057251..3058963) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" /label="alsS CDS" gene complement(3057251..3058963) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /label="alsS gene" promotor_-35 3057862..3057871 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3057885..3057904 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3057885 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3059017..3059036) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3059022) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3059042..3059049 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3059051..3059055) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3059063..3059082 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3059073 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="upshifts" CDS 3059121..3060029 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" /label="alsR CDS" gene 3059121..3060029 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /label="alsR gene" promotor_-35 3060097..3060105 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3060107..3060239 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 3060107 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3060119..3060138 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3060240..3061568 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" /label="ywrK CDS" gene 3060240..3061568 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /label="ywrK gene" downshifts 3061559 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3061625..3062302) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" /label="ywrJ CDS" gene complement(3061625..3062302) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /label="ywrJ gene" downshifts complement(3061635) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3062362..3063504) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" /label="cotB CDS" gene complement(3062362..3063504) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /label="cotB gene" promotor_-10 complement(3063541..3063560) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3063549) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3063551..3063631) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(3063574..3063582) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3063632..3064720) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" /label="cotH CDS" gene complement(3063632..3064720) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /label="cotH gene" S_feature complement(3064721..3064834) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 3064776..3064785 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3064798..3064817 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3064811 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3064834) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3064838..3064852) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3064861..3064865) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3064861..3065448 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" /label="cotG CDS" gene 3064861..3065448 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /label="cotG gene" CDS 3064949..3065428 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " /label="doubtful CDS (putative in frame frameshift)" gene 3064949..3065428 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /label="gene" S_feature complement(3065332..3065529) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 3065365 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(3065375) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" /label="downshifts" downshifts 3065434 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts 3065513 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3065528..3065547) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3065534) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3065556..3065563 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3065560..3065569) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3065578..3065597 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3065584 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="upshifts" CDS 3065622..3066239 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" /label="ywrF CDS" gene 3065622..3066239 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /label="ywrF gene" S_feature 3066240..3066340 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 3066297 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" /label="downshifts" promotor_-35 3066366..3066375 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3066387..3066402 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3066388 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3066417..3066752 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" /label="ywrE CDS" gene 3066417..3066752 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /label="ywrE gene" promotor_-10 complement(3066708..3066726) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3066717) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3066741..3066746) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3066751 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3066757..3068334) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" /label="hpxW CDS" gene complement(3066757..3068334) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /label="hpxW gene" S_feature 3066796..3068507 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 3068485..3068492 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3068503..3068522 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3068509 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3068548..3069024 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" /label="chrS CDS" gene 3068548..3069024 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /label="chrS gene" CDS 3069038..3069631 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" /label="chrB CDS" gene 3069038..3069631 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /label="chrB gene" CDS 3069628..3070164 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" /label="chrA CDS" gene 3069628..3070164 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /label="chrA gene" downshifts 3070145 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(3070191..3070412) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" /label="ywqO CDS" gene complement(3070191..3070412) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /label="ywqO gene" upshifts 3070359 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3070366..3070367 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3070409..3070954) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" /label="ywqN CDS" gene complement(3070409..3070954) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /label="ywqN gene" promotor_-35 3070971..3070978 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3070993..3071012 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3070997 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="upshifts" CDS 3071077..3071958 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" /label="ywqM CDS" gene 3071077..3071958 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /label="ywqM gene" CDS complement(3072043..3072759) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" /label="nfi CDS" gene complement(3072043..3072759) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /label="nfi gene" downshifts complement(3072063) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3072769..3073233) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" /label="rttO CDS" gene complement(3072769..3073233) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /label="rttO gene" CDS complement(3073223..3075031) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" /label="rttN CDS" gene complement(3073223..3075031) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /label="rttN gene" CDS complement(3075050..3075310) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" /label="ywqI CDS" gene complement(3075050..3075310) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /label="ywqI gene" CDS complement(3075320..3075742) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" /label="ywqH CDS" gene complement(3075320..3075742) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /label="ywqH gene" S_feature complement(3075743..3075825) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(3075817..3075836) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3075825) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3075849..3075856) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3075959..3076084) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" /label="hypothetical protein CDS" gene complement(3075959..3076084) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /label="gene" S_feature complement(3076002..3076133) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(3076045) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3076134..3076919) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" /label="ywqG CDS" gene complement(3076134..3076919) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /label="ywqG gene" S_feature complement(3076920..3077035) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(3077028..3077047) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3077035) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3077061..3077068) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3077111..3078433) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" /label="uglF CDS" gene complement(3077111..3078433) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /label="uglF gene" downshifts complement(3077123) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3078467) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3078469..3078594) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(3078469..3078487) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3078503..3078508) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3078574..3078593) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3078594) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3078628..3079392) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" /label="ptpZ CDS" gene complement(3078628..3079392) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /label="ptpZ gene" downshifts complement(3079411) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(3079445..3080158) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" /label="ptkA CDS" gene complement(3079445..3080158) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /label="ptkA gene" downshifts complement(3079462) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" /label="downshifts" CDS complement(3080148..3080894) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" /label="tkmA CDS" gene complement(3080148..3080894) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /label="tkmA gene" promotor_-10 complement(3080926..3080945) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3080938) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3080962..3080965) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3081128..3081271) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" /label="ywzD CDS" gene complement(3081128..3081271) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /label="ywzD gene" downshifts complement(3081149) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3081272..3081357) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(3081347..3081358) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3081357) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3081359..3081589) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 3081396..3081400 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3081416..3081435 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3081425 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="upshifts" CDS 3081475..3083085 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" /label="ywqB CDS" gene 3081475..3083085 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /label="ywqB gene" promotor_-10 complement(3081577..3081595) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3081589) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3081591..3081765) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(3081609..3081616) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3081752..3081771) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3081765) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3081785..3081793) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3083072..3085840 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" /label="hepA CDS" gene 3083072..3085840 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /label="hepA gene" downshifts complement(3085889) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3085966..3086823) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" /label="ywpJ CDS" gene complement(3085966..3086823) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /label="ywpJ gene" CDS complement(3086829..3087605) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" /label="glcR CDS" gene complement(3086829..3087605) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /label="glcR gene" promotor_-10 complement(3087631..3087650) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3087653) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3087655..3087727) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(3087665..3087672) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3087729..3087828) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(3087772) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(3087829..3088170) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" /label="ssbB CDS" gene complement(3087829..3088170) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /label="ssbB gene" promotor_-10 complement(3088192..3088211) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3088211) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3088225..3088232) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3088247..3088630) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" /label="ywpG CDS" gene complement(3088247..3088630) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /label="ywpG gene" promotor_-10 complement(3088652..3088671) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 3088659..3088678 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3088663 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3088672) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="upshifts" promotor_-35 complement(3088686..3088693) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 3088753..3088772 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3088756 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3088805) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS 3088805..3089215 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" /label="ywpF CDS" gene 3088805..3089215 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /label="ywpF gene" S_feature 3089216..3089299 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 3089257 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3089355..3089663) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" /label="ywpE CDS" gene complement(3089355..3089663) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /label="ywpE gene" downshifts complement(3089356) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS 3090007..3090843 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" /label="ywpD CDS" gene 3090007..3090843 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /label="ywpD gene" promotor_-35 3090223..3090230 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3090245..3090264 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3090248 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3090842 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" /label="downshifts" CDS complement(3090890..3091282) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" /label="mscL CDS" gene complement(3090890..3091282) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /label="mscL gene" downshifts complement(3090896) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3091355..3091780) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" /label="fabZ CDS" gene complement(3091355..3091780) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /label="fabZ gene" promotor_-10 complement(3091841..3091860) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3091857) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3091859..3091943) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(3091875..3091882) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3091922 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3091925..3091944 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3091935..3091954) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(3091943) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="upshifts" S_feature complement(3091945..3093029) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(3091968..3091973) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 3091972..3093036 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" /label="rapD CDS" gene 3091972..3093036 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /label="rapD gene" S_feature 3093037..3093921 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(3093059..3093868) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" /label="flhP CDS" gene complement(3093059..3093868) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /label="flhP gene" downshifts complement(3093074) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3093902..3094714) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" /label="flhO CDS" gene complement(3093902..3094714) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /label="flhO gene" S_feature complement(3094715..3094794) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 3094745..3094752 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3094766..3094785 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3094775 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3094788..3094806) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(3094794) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="upshifts" promotor_-35 complement(3094820..3094827) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(3094877..3095878) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " /label="mbl CDS" gene complement(3094877..3095878) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /label="mbl gene" downshifts complement(3094883) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" misc_feature complement(3095933..3095952) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3095957) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="upshifts" S_feature complement(3095959..3096043) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(3096044..3096325) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" /label="spoIIID CDS" gene complement(3096044..3096325) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /label="spoIIID gene" CDS complement(3096340..3096450) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" /label="usd CDS" gene complement(3096340..3096450) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /label="usd gene" promotor_-10 complement(3096481..3096499) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3096503) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3096515..3096520) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3096596..3096602 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3096616..3096635 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3096632 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="upshifts" CDS 3096675..3097088 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" /label="ywoH CDS" gene 3096675..3097088 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /label="ywoH gene" CDS 3097110..3098300 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" /label="ywoG CDS" gene 3097110..3098300 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /label="ywoG gene" CDS complement(3098391..3099797) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" /label="ywoF CDS" gene complement(3098391..3099797) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /label="ywoF gene" downshifts complement(3098688) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3099830..3099849) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3099848) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3099864..3099867) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3099903..3101375) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" /label="pucI CDS" gene complement(3099903..3101375) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /label="pucI gene" CDS complement(3101556..3102914) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" /label="ywoD CDS" gene complement(3101556..3102914) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /label="ywoD gene" downshifts complement(3101570) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3102914..3103483) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" /label="ywoC CDS" gene complement(3102914..3103483) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /label="ywoC gene" promotor_-10 complement(3103502..3103513) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3103520) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3103527..3103533) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3103590..3103757) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" /label="hypothetical protein CDS" gene complement(3103590..3103757) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo /label="gene" CDS complement(3103667..3104131) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" /label="ywoB CDS" gene complement(3103667..3104131) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /label="ywoB gene" promotor_-10 complement(3104161..3104180) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3104166) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3104194..3104201) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3104332..3104335 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3104350..3104369 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3104354 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3104413..3105627 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" /label="amtB CDS" gene 3104413..3105627 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /label="amtB gene" promotor_-10 complement(3105243..3105261) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3105244) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3105275..3105282) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3105493..3105499 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3105513..3105532 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3105515 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3105639..3105989 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" /label="glnK CDS" gene 3105639..3105989 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /label="glnK gene" downshifts 3105982 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3106041..3106049 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3106063..3106071 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3106070 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3106112..3106121 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3106134..3106149 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3106138 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" CDS 3106170..3106751 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" /label="bcrC CDS" gene 3106170..3106751 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /label="bcrC gene" promotor_-10 complement(3106268..3106287) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3106278) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3106301..3106309) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3106732 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(3106792..3107214) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" /label="ywnJ CDS" gene complement(3106792..3107214) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /label="ywnJ gene" downshifts complement(3106811) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3107249..3107264) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3107268) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3107277..3107286) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3107325..3108176) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" /label="spoIIQ CDS" gene complement(3107325..3108176) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /label="spoIIQ gene" downshifts complement(3107334) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts complement(3107576) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" promotor_-35 3107813..3107815 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3107832..3107851 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3107833..3108179 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3107833 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3108171..3108174 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3108181..3108316 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3108181 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3108210) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3108216..3108225) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3108317..3108808 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" /label="ywnH CDS" gene 3108317..3108808 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /label="ywnH gene" promotor_-35 3108546..3108551 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3108567..3108585 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3108578 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3108669..3109577) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3108805..3109323 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" /label="ywnG CDS" gene 3108805..3109323 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /label="ywnG gene" downshifts 3109128 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 3109326 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3109482..3109613 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " /label="hypothetical protein CDS" gene 3109482..3109613 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /label="gene" CDS complement(3109610..3110044) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" /label="ywnF CDS" gene complement(3109610..3110044) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /label="ywnF gene" downshifts complement(3109622) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3110093..3110112) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3110100) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3110102..3110399) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3110127..3110134) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3110173..3110177 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3110194..3110213 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3110206..3110286 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3110207 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3110287..3111735 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" /label="clsA CDS" gene 3110287..3111735 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /label="clsA gene" upshifts complement(3110399) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3110400..3110418) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3110401..3110744) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3110434..3110440) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3110722..3110740) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3110744) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3110756..3110761) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3111724 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3111756..3112529) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" /label="mta CDS" gene complement(3111756..3112529) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /label="mta gene" downshifts complement(3111778) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" promotor_-35 3112604..3112607 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3112623..3112642 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3112627 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="upshifts" CDS 3112674..3113057 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" /label="ywnC CDS" gene 3112674..3113057 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /label="ywnC gene" downshifts 3113044 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3113092..3113733) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" /label="ywnB CDS" gene complement(3113092..3113733) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /label="ywnB gene" downshifts complement(3113142) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3113801..3114202) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" /label="ywnA CDS" gene complement(3113801..3114202) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /label="ywnA gene" promotor_-10 complement(3114251..3114270) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3114261) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3114263..3114336) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3114285..3114290) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3114337..3116046) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" /label="ureC CDS" gene complement(3114337..3116046) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /label="ureC gene" CDS complement(3116043..3116417) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" /label="ureB CDS" gene complement(3116043..3116417) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /label="ureB gene" CDS complement(3116414..3116731) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" /label="ureA CDS" gene complement(3116414..3116731) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /label="ureA gene" S_feature complement(3116732..3116816) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3116816) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3116818..3116831) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3116818..3116911) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3116912..3117076) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" /label="ywzE CDS" gene complement(3116912..3117076) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /label="ywzE gene" promotor_-10 complement(3116999..3117017) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3117011) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="upshifts" promotor_-35 complement(3117029..3117037) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3117077..3117248) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3117249..3117431) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" /label="ywzF CDS" gene complement(3117249..3117431) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo /label="ywzF gene" S_feature complement(3117432..3117578) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3117566..3117585) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3117578) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" S_feature complement(3117580..3117694) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3117600..3117607) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" Polymorphism join(3117681,3117683) /Source="geneious" /ID="SNP_BsDelta6_3770059_3770058" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)8 -> (A)9" /Codon_Change /Coverage=64 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="2.1e-197" /Variant_Raw_Frequency=61 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 3117708 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3117711..3117715 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3117728..3117916) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" /label="csbD CDS" gene complement(3117728..3117916) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /label="csbD gene" downshifts complement(3117739) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" /label="downshifts" downshifts 3117906 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3117942..3117960) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3117953) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3117974..3117980) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3117989..3118489) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" /label="ywmF CDS" gene complement(3117989..3118489) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /label="ywmF gene" promotor_-10 complement(3118525..3118544) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3118532) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3118558..3118564) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3118624..3119757) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" /label="rapB CDS" gene complement(3118624..3119757) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /label="rapB gene" downshifts complement(3118642) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3119784..3119803) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3119791) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3119854..3119872) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3119870) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3119886..3119893) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3119949..3120974) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" /label="moaA CDS" gene complement(3119949..3120974) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /label="moaA gene" downshifts complement(3119962) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3120990..3121778) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" /label="fdhD CDS" gene complement(3120990..3121778) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /label="fdhD gene" promotor_-10 complement(3121804..3121823) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3121810) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3121812..3122023) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3121837..3121844) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3122024..3122185) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" /label="ywmE CDS" gene complement(3122024..3122185) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /label="ywmE gene" promotor_-10 complement(3122198..3122216) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3122218) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="upshifts" promotor_-35 complement(3122230..3122236) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3122279..3122953) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" /label="ywmD CDS" gene complement(3122279..3122953) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /label="ywmD gene" downshifts complement(3122294) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3123006..3123146) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" /label="hypothetical protein CDS" gene complement(3123006..3123146) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /label="gene" CDS complement(3123277..3123960) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" /label="ywmC CDS" gene complement(3123277..3123960) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /label="ywmC gene" promotor_-35 3124337..3124341 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3124346..3125377) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" /label="spoIID CDS" gene complement(3124346..3125377) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /label="spoIID gene" promotor_-10 3124356..3124375 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3124362) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3124374 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3125405..3125423) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3125418) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3125420..3125537) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3125439..3125444) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3125479..3125484 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3125496..3128156 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3125496 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3125500..3125518 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3125573..3126883) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" /label="murAA CDS" gene complement(3125573..3126883) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /label="murAA gene" downshifts complement(3125582) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3126907..3126926) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3126914) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3126917..3127657) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" /label="ywmB CDS" gene complement(3126917..3127657) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /label="ywmB gene" promotor_-35 complement(3126940..3126949) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3127288) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3127290..3127298) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3127312..3127320) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3127412..3127427) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3127420) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3127440..3127449) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3127658..3127785) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3127786..3128016) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" /label="ywzB CDS" gene complement(3127786..3128016) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /label="ywzB gene" S_feature complement(3128017..3128279) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3128152..3128171 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3128158 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="upshifts" CDS 3128186..3128659 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" /label="ywmA CDS" gene 3128186..3128659 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /label="ywmA gene" promotor_-10 complement(3128263..3128282) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3128279) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="upshifts" S_feature complement(3128281..3128664) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3128297..3128300) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3128693..3129091) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" /label="atpC CDS" gene complement(3128693..3129091) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /label="atpC gene" downshifts complement(3128709) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3129083..3129101) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3129092) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3129115..3129121) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3129115..3130536) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" /label="atpD CDS" gene complement(3129115..3130536) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /label="atpD gene" CDS complement(3130562..3131425) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" /label="atpG CDS" gene complement(3130562..3131425) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /label="atpG gene" S_feature complement(3131426..3131501) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3131502..3133010) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" /label="atpA CDS" gene complement(3131502..3133010) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /label="atpA gene" CDS complement(3133027..3133572) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" /label="atpH CDS" gene complement(3133027..3133572) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /label="atpH gene" CDS complement(3133569..3134081) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" /label="atpF CDS" gene complement(3133569..3134081) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /label="atpF gene" S_feature complement(3134082..3134243) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3134244..3134456) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" /label="atpE CDS" gene complement(3134244..3134456) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /label="atpE gene" CDS complement(3134502..3135236) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" /label="atpB CDS" gene complement(3134502..3135236) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /label="atpB gene" promotor_no_box 3135050..3135150 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3135110 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3135244..3135627) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" /label="atpI CDS" gene complement(3135244..3135627) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /label="atpI gene" misc_feature complement(3135316..3135334) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3135318) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3135628..3135898) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3135860..3135869 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3135869 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3135874..3135893) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3135883..3135902 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3135898) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3135900..3136021) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3135906..3135913) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3136050..3136679) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" /label="upp CDS" gene complement(3136050..3136679) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /label="upp gene" downshifts complement(3136066) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3136723..3136742) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3136746) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" promotor_-35 complement(3136757..3136764) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3136814..3138061) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" /label="glyA CDS" gene complement(3136814..3138061) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /label="glyA gene" downshifts complement(3136837) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3138103..3138122) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3138120) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3138122..3138206) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3138137..3138142) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3138251) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" /label="downshifts" CDS complement(3138268..3138810) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" /label="ywlG CDS" gene complement(3138268..3138810) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /label="ywlG gene" CDS complement(3138823..3139272) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" /label="rpiB CDS" gene complement(3138823..3139272) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /label="rpiB gene" S_feature complement(3139273..3139372) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3139364..3139383) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3139372) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="upshifts" promotor_-35 complement(3139397..3139404) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3139429..3139881) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" /label="prpB CDS" gene complement(3139429..3139881) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /label="prpB gene" promotor_-10 complement(3139898..3139917) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3139916) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="upshifts" promotor_-35 complement(3139932..3139935) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3139957..3140514) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" /label="mntP CDS" gene complement(3139957..3140514) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /label="mntP gene" promotor_-10 complement(3140541..3140559) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3140554) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="upshifts" promotor_-35 complement(3140575..3140580) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3140593..3141633) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" /label="tsaC CDS" gene complement(3140593..3141633) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /label="tsaC gene" downshifts complement(3140598) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3141634..3141698) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3141688..3141707) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3141698) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3141700..3141789) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3141723..3141727) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3141790..3142233) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" /label="ywlB CDS" gene complement(3141790..3142233) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /label="ywlB gene" CDS complement(3142300..3142974) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" /label="spoIIR CDS" gene complement(3142300..3142974) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /label="spoIIR gene" promotor_-10 complement(3142736..3142754) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3142743) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3142769..3142775) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3143006..3143023) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3143007) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3143039..3143044) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3143080 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3143084..3143103 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3143115..3143477 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" /label="ywlA CDS" gene 3143115..3143477 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /label="ywlA gene" downshifts complement(3143490) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3143494..3143781) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" /label="ywkF CDS" gene complement(3143494..3143781) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /label="ywkF gene" S_feature complement(3143782..3143840) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3143838..3143857) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3143841..3144707) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" /label="prmC CDS" gene complement(3143841..3144707) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /label="prmC gene" upshifts complement(3143854) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3143870..3143879) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3144709..3145779) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" /label="prfA CDS" gene complement(3144709..3145779) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /label="prfA gene" downshifts complement(3144712) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" downshifts 3145780 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3145807..3145826) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3145831) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3145833..3145944) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3145840..3145846) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3145876..3145895 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3145890 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3145905..3146291 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" /label="ywkD CDS" gene 3145905..3146291 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /label="ywkD gene" promotor_-10 complement(3145926..3145944) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3145944) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="upshifts" promotor_-35 complement(3145958..3145965) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3146359..3146367 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3146378..3146396 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3146379 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3146413..3146967 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" /label="racA CDS" gene 3146413..3146967 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /label="racA gene" misc_feature 3146897..3146901 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3146902 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3146946 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3147001..3147960) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" /label="ywkB CDS" gene complement(3147001..3147960) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /label="ywkB gene" downshifts complement(3147023) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3147998..3148016) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3148012) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3148031..3148037) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3148042..3149790) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" /label="maeA CDS" gene complement(3148042..3149790) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /label="maeA gene" promotor_-10 complement(3148516..3148534) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3148524) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3148549..3148555) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3149791..3149881) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3149865..3149884) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3149881) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3149898..3149905) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3150024) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(3150029..3150616) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" /label="tdk CDS" gene complement(3150029..3150616) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /label="tdk gene" CDS complement(3150705..3150905) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" /label="rpmEA CDS" gene complement(3150705..3150905) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /label="rpmEA gene" downshifts complement(3150718) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3150906..3150983) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3150979..3150998) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3150983) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3151012..3151019) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3151024..3152307) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" /label="rho CDS" gene complement(3151024..3152307) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /label="rho gene" S_feature complement(3152308..3152610) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3152338..3152499) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" /label="hypothetical protein CDS" gene complement(3152338..3152499) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /label="gene" promotor_-10 complement(3152590..3152609) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3152610) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3152625..3152629) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3152714..3153679) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" /label="glpX CDS" gene complement(3152714..3153679) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /label="glpX gene" downshifts complement(3152720) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 3153296..3153305 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3153318..3153337 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3153326 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3153710..3154999) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" /label="murAB CDS" gene complement(3153710..3154999) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /label="murAB gene" S_feature complement(3155000..3155359) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3155378..3156016) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" /label="tal CDS" gene complement(3155378..3156016) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /label="tal gene" downshifts complement(3155404) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" S_feature complement(3156017..3156135) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3156136..3156993) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" /label="fbaA CDS" gene complement(3156136..3156993) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /label="fbaA gene" S_feature complement(3156994..3157120) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3157102..3157121) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3157120) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="upshifts" promotor_-35 complement(3157135..3157142) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3157174..3157548) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" /label="spo0F CDS" gene complement(3157174..3157548) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /label="spo0F gene" promotor_-10 complement(3157588..3157606) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3157602) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="upshifts" S_feature complement(3157604..3158243) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3157605..3157608 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3157617..3157625) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3157624..3157643 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3157637 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3157651..3157656 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3157672..3157691 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3157682 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" CDS 3157714..3158235 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" /label="ywjG CDS" gene 3157714..3158235 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /label="ywjG gene" promotor_-35 3158178..3158181 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3158196..3158215 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3158210 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3158233..3158252) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3158243) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="upshifts" downshifts 3158254 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3158267..3158274) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3158317..3159924) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" /label="pyrG CDS" gene complement(3158317..3159924) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /label="pyrG gene" downshifts complement(3158330) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3159925..3160112) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3160100..3160119) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3160112) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3160134..3160141) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3160166..3160687) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" /label="rpoE CDS" gene complement(3160166..3160687) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /label="rpoE gene" downshifts complement(3160222) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" S_feature complement(3160688..3160790) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3160771..3160790) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3160790) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3160792..3160869) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3160806..3160809) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3160870..3162009) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" /label="acdA CDS" gene complement(3160870..3162009) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /label="acdA gene" CDS complement(3162006..3164123) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" /label="fadF CDS" gene complement(3162006..3164123) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /label="fadF gene" S_feature complement(3164124..3164182) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3164183..3164202) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3164196) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3164216..3164223) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3164222..3164228 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3164242..3164253 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3164247 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="upshifts" CDS 3164278..3165474 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" /label="clsB CDS" gene 3164278..3165474 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /label="clsB gene" S_feature complement(3164470..3165348) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3165338..3165356) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3165349) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3165372..3165377) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3165487..3166449 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" /label="uvsE CDS" gene 3165487..3166449 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /label="uvsE gene" promotor_-35 3166463..3166469 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3166484..3166502 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3166484 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="upshifts" CDS 3166530..3166802 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" /label="ywjC CDS" gene 3166530..3166802 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /label="ywjC gene" downshifts complement(3166536) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 3166792 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" /label="downshifts" S_feature 3166837..3167243 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3166844..3167368) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" /label="ywjB CDS" gene complement(3166844..3167368) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /label="ywjB gene" downshifts complement(3166866) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3167378..3169105) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" /label="ywjA CDS" gene complement(3167378..3169105) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /label="ywjA gene" promotor_-10 complement(3169139..3169158) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3169153) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3169172..3169178) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3169194..3170696) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" /label="clsC CDS" gene complement(3169194..3170696) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /label="clsC gene" promotor_-10 complement(3170720..3170738) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3170738) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3170753..3170759) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3170783..3171155) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3170826) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3171182..3171853) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" /label="narI CDS" gene complement(3171182..3171853) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /label="narI gene" downshifts complement(3171200) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(3171850..3172404) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" /label="narJ CDS" gene complement(3171850..3172404) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /label="narJ gene" CDS complement(3172430..3173893) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" /label="narH CDS" gene complement(3172430..3173893) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /label="narH gene" CDS complement(3173883..3177569) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" /label="narG CDS" gene complement(3173883..3177569) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /label="narG gene" misc_feature complement(3177600..3177619) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3177624) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3177626..3177755) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3177765..3178241) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" /label="arfM CDS" gene complement(3177765..3178241) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /label="arfM gene" downshifts complement(3177800) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3178264..3178283) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3178276) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="upshifts" promotor_-35 complement(3178298..3178301) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3178348 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3178351..3178370 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3178385..3179104 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" /label="ywiC CDS" gene 3178385..3179104 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /label="ywiC gene" downshifts 3179088 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3179136..3179852) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" /label="fnr CDS" gene complement(3179136..3179852) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /label="fnr gene" downshifts complement(3179138) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" /label="downshifts" downshifts complement(3179208) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" misc_feature complement(3179878..3179897) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3179890) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3179951..3181138) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" /label="narK CDS" gene complement(3179951..3181138) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /label="narK gene" misc_feature complement(3181168..3181187) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3181186) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3181274..3182944) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" /label="argS CDS" gene complement(3181274..3182944) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /label="argS gene" downshifts complement(3181276) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3182941..3183369) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" /label="ywiB CDS" gene complement(3182941..3183369) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /label="ywiB gene" misc_feature 3183437..3183451 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3183437..3183456) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3183444 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3183453) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3183473..3183476) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3183508..3183527) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3183520) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="upshifts" SCAR join(3183549,3183556) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs09" N_region 3183550..3183555 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs09" S_feature <3183556..3186034 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3183557..3184933) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" /label="ywhL CDS" gene complement(3183557..3184933) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /label="ywhL gene" CDS complement(3184972..3186327) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" /label="ywhK CDS" gene complement(3184972..3186327) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /label="ywhK gene" promotor_-10 complement(3186363..3186382) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3186381) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3186395..3186404) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3186507..3186526 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3186508 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3186553) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" /label="downshifts" CDS 3186557..3187702 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" /label="rapF CDS" gene 3186557..3187702 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /label="rapF gene" promotor_-35 3187561..3187565 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3187582..3187601 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3187589 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3187672) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 3187686..3187805 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" /label="phrF CDS" gene 3187686..3187805 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /label="phrF gene" downshifts 3187790 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" S_feature 3187835..3187903 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3187904..3188377 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" /label="ywhH CDS" gene 3187904..3188377 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /label="ywhH gene" downshifts 3188366 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3188409..3189281) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" /label="speB CDS" gene complement(3188409..3189281) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /label="speB gene" downshifts complement(3188420) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3188486) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(3189342..3190172) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" /label="speE CDS" gene complement(3189342..3190172) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /label="speE gene" S_feature complement(3190173..3190268) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3190256..3190275) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3190267) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3190288..3190295) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3190313..3190318 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3190334..3190352 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3190336 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="upshifts" CDS 3190374..3192449 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" /label="pbpG CDS" gene 3190374..3192449 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /label="pbpG gene" downshifts complement(3192502) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(3192626..3192741) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3192669) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" /label="downshifts" CDS complement(3192742..3193260) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" /label="ywhD CDS" gene complement(3192742..3193260) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /label="ywhD gene" CDS complement(3193274..3193933) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" /label="ywhC CDS" gene complement(3193274..3193933) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /label="ywhC gene" promotor_-35 3193956..3193959 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3193969..3193988) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3193974..3193993 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3193977 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3193987) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3193989..3194272) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3194003..3194010) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3194042..3194230 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" /label="hmtB CDS" gene 3194042..3194230 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /label="hmtB gene" downshifts 3194219 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3194273..3194692) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" /label="ywhA CDS" gene complement(3194273..3194692) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /label="ywhA gene" promotor_-10 complement(3194742..3194761) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3194753) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3194776..3194783) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3194812..3196728) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" /label="thrZ CDS" gene complement(3194812..3196728) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /label="thrZ gene" promotor_-10 complement(3196006..3196024) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3196011) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3196041..3196045) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3196759) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3196782..3197003) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTB RNA" gene complement(3196782..3197003) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /label="tboTB gene" misc_RNA complement(3197035..3197256) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTA RNA" gene complement(3197035..3197256) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /label="tboTA gene" S_feature complement(3197288..3197550) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3197299 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" /label="downshifts" downshifts complement(3197331) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3197338..3197493) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" /label="hypothetical protein CDS" gene complement(3197338..3197493) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /label="gene" promotor_-35 3197500..3197503 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3197512..3197525 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3197519 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3197527..3197546) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3197550) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3197560..3197566) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3197573..3198973) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" /label="mmr CDS" gene complement(3197573..3198973) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /label="mmr gene" CDS complement(3198973..3199443) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" /label="ywgB CDS" gene complement(3198973..3199443) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /label="ywgB gene" downshifts complement(3199399) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3199555..3200055) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" /label="ywgA CDS" gene complement(3199555..3200055) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /label="ywgA gene" downshifts complement(3199558) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" /label="downshifts" CDS complement(3200091..3201392) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" /label="ywfO CDS" gene complement(3200091..3201392) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /label="ywfO gene" promotor_-10 complement(3201416..3201435) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3201430) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3201432..3201553) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3201451..3201453) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3201554..3201778) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" /label="ywzC CDS" gene complement(3201554..3201778) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /label="ywzC gene" S_feature complement(3201779..3201863) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3201852..3201871) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3201862) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3201886..3201889) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3201929..3201935 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3201950..3201961 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3201951 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="upshifts" CDS 3201993..3202769 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" /label="psrF CDS" gene 3201993..3202769 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /label="psrF gene" downshifts 3202755 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" /label="downshifts" promotor_-35 3202857..3202864 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3202879..3202898 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3202883..3207109 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3202883 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3202913..3203803) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" /label="ywfM CDS" gene complement(3202913..3203803) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /label="ywfM gene" promotor_no_box complement(3203803..3203903) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3203843) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3203971..3204816) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" /label="lipL CDS" gene complement(3203971..3204816) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /label="lipL gene" downshifts complement(3204134) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" /label="downshifts" CDS complement(3204865..3205764) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" /label="cysL CDS" gene complement(3204865..3205764) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /label="cysL gene" promotor_-10 complement(3205807..3205826) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3205810) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3205840..3205847) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3205911) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3205911..3206882) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" /label="pta CDS" gene complement(3205911..3206882) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /label="pta gene" promotor_-10 complement(3206917..3206936) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3206942) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3206952..3206956) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3207030..3207041) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3207033) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3207055..3207061) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3207104..3207123 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3207111 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3207152..3207916 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" /label="hemQ CDS" gene 3207152..3207916 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /label="hemQ gene" downshifts 3207903 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(3207923,3207930) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs11" N_region 3207924..3207929 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs11" S_feature <3207930..3207982 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" CDS complement(3207932..3209170) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" /label="ywfA CDS" gene complement(3207932..3209170) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /label="ywfA gene" promotor_-10 complement(3209212..3209231) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3209224) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3209243..3209250) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3209380..3210792) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" /label="rocC CDS" gene complement(3209380..3210792) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /label="rocC gene" downshifts complement(3209387) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3210792..3212492) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" /label="rocB CDS" gene complement(3210792..3212492) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /label="rocB gene" misc_feature complement(3211461..3211477) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3211473) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3212566..3214113) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" /label="rocA CDS" gene complement(3212566..3214113) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /label="rocA gene" downshifts complement(3212573) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3214157) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3214159..3214339) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3214160..3214178) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3214340..3215614) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" /label="rocG CDS" gene complement(3214340..3215614) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /label="rocG gene" S_feature complement(3215615..3215697) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3215697) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3215710..3215728) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3215790) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" /label="downshifts" CDS complement(3215791..3216255) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" /label="bslB CDS" gene complement(3215791..3216255) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /label="bslB gene" S_feature complement(3216256..3216366) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3216348..3216367) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3216366) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="upshifts" promotor_-35 complement(3216382..3216389) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3216577) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3216579..3217034) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" /label="spsL CDS" gene complement(3216579..3217034) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /label="spsL gene" misc_feature 3216669..3216688 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3216677 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3217027..3217878) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" /label="spsK CDS" gene complement(3217027..3217878) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /label="spsK gene" CDS complement(3217892..3218839) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" /label="spsJ CDS" gene complement(3217892..3218839) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /label="spsJ gene" CDS complement(3218839..3219579) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" /label="spsI CDS" gene complement(3218839..3219579) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /label="spsI gene" promotor_-35 3219597..3219602 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3219603 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3219604..3220623) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" /label="spsG CDS" gene complement(3219604..3220623) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /label="spsG gene" promotor_-10 3219617..3219635 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3220487..3220496 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3220509..3220524 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3220520 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3220626..3221348) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" /label="spsF CDS" gene complement(3220626..3221348) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /label="spsF gene" CDS complement(3221341..3222462) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" /label="spsE CDS" gene complement(3221341..3222462) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /label="spsE gene" CDS complement(3222462..3223331) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" /label="spsD CDS" gene complement(3222462..3223331) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /label="spsD gene" CDS complement(3223332..3224501) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" /label="spsC CDS" gene complement(3223332..3224501) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /label="spsC gene" CDS complement(3224522..3225946) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" /label="spsB CDS" gene complement(3224522..3225946) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /label="spsB gene" CDS complement(3225951..3226721) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" /label="spsA CDS" gene complement(3225951..3226721) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /label="spsA gene" promotor_-10 complement(3226756..3226775) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3226770) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3226789..3226798) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3226889..3226894 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3226910..3226928 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3226912..3227040 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3226912 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="upshifts" CDS 3227041..3227586 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" /label="gerQ CDS" gene 3227041..3227586 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /label="gerQ gene" downshifts 3227572 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3227630..3228001) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" /label="ywdK CDS" gene complement(3227630..3228001) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /label="ywdK gene" downshifts complement(3227648) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3228063..3229385) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" /label="ywdJ CDS" gene complement(3228063..3229385) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /label="ywdJ gene" CDS complement(3229405..3229722) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" /label="ywdI CDS" gene complement(3229405..3229722) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /label="ywdI gene" promotor_-10 complement(3229751..3229770) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3229762) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3229784..3229790) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3229825..3229832 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3229848..3229867 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3229851 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="upshifts" CDS 3229890..3231260 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" /label="ywdH CDS" gene 3229890..3231260 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /label="ywdH gene" CDS complement(3231285..3231962) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" /label="ung CDS" gene complement(3231285..3231962) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /label="ung gene" downshifts complement(3231299) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3231789..3231808) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3231805) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3231824..3231829) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3231976..3232782) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" /label="ywdF CDS" gene complement(3231976..3232782) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /label="ywdF gene" promotor_-10 complement(3232275..3232293) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3232289) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3232308..3232314) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3232811..3232830) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3232817) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3232846..3232853) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3232872..3233405) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" /label="ywdE CDS" gene complement(3232872..3233405) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /label="ywdE gene" CDS complement(3233453..3234088) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" /label="ywdD CDS" gene complement(3233453..3234088) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /label="ywdD gene" CDS complement(3234081..3234419) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" /label="ywzG CDS" gene complement(3234081..3234419) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /label="ywzG gene" promotor_-10 complement(3234441..3234460) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3234452) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3234475..3234482) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3234503..3234506 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3234521..3234540 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3234521 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="upshifts" CDS 3234563..3235378 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" /label="pdxK CDS" gene 3234563..3235378 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /label="pdxK gene" downshifts 3235357 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3235433) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3235468..3235716) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" /label="ywdA CDS" gene complement(3235468..3235716) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /label="ywdA gene" downshifts complement(3235488) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" /label="downshifts" upshifts complement(3235734) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3235736..3235809) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3235744..3235750) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3235810..3237249) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" /label="sacA CDS" gene complement(3235810..3237249) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /label="sacA gene" CDS complement(3237246..3238631) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" /label="sacP CDS" gene complement(3237246..3238631) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /label="sacP gene" misc_feature complement(3238650..3238659) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3238664) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3238666..3238730) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3238709..3238726) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3238730) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3238742..3238749) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3238772..3238791) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3238790) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3238805..3238812) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3238871..3238874 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3238881 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3238889..3238908 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3238933..3239703 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" /label="nirC CDS" gene 3238933..3239703 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /label="nirC gene" S_feature 3239704..3240771 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3239742..3240572) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" /label="sacT CDS" gene complement(3239742..3240572) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /label="sacT gene" downshifts complement(3239743) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3240598..3240617) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3240604) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3240612..3240914) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" /label="ywcI CDS" gene complement(3240612..3240914) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /label="ywcI gene" promotor_-35 complement(3240632..3240639) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3240915..3241053) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3241038..3241057) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3241053) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3241368..3241376 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3241387..3241405 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3241388 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="upshifts" CDS 3241444..3241521 /gene="vpr" /old_locus_tag="BSU_38090" /created_by="User" /modified_by="User" /transl_table=11 /locus_tag="PG10_BSU_38090-3'_ext" /translation="MKKGISQQTPPAISDTIGAYLQNDA*" /label="PG10_BSU_38090-3'_ext" gene 3241444..3241521 /gene="vpr_3'-chimera" /old_locus_tag="BSU_38090" /created_by="User" /locus_tag="PG10_BSU_38090-3'_ext" /label="PG10_BSU_38090-3'_ext" SCAR 3241454..3241455 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_017" CDS complement(3241457..3242458) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " /label="ywcH CDS" gene complement(3241457..3242458) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /label="ywcH gene" S_feature complement(3242459..3242620) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3242632..3243381) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" /label="nfrAA CDS" gene complement(3242632..3243381) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /label="nfrAA gene" downshifts complement(3242665) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3243399..3243418) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3243416) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3243433..3243436) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3243487..3244668) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" /label="rodA CDS" gene complement(3243487..3244668) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /label="rodA gene" downshifts complement(3243501) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3244669..3244800) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3244794..3244809) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3244800) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="upshifts" promotor_-35 complement(3244821..3244830) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3245035..3245042 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3245053..3245163 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3245053..3245072 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3245053 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="upshifts" CDS 3245164..3245427 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" /label="ywcE CDS" gene 3245164..3245427 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /label="ywcE gene" downshifts 3245317 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3245433 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3245470..3245844) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" /label="qoxD CDS" gene complement(3245470..3245844) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /label="qoxD gene" downshifts complement(3245481) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3245846..3246460) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" /label="qoxC CDS" gene complement(3245846..3246460) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /label="qoxC gene" CDS complement(3246474..3248423) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" /label="qoxB CDS" gene complement(3246474..3248423) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /label="qoxB gene" misc_feature 3247687..3247706 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3247693 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3248117..3248217 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3248177 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3248287 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" CDS complement(3248451..3249416) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" /label="qoxA CDS" gene complement(3248451..3249416) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /label="qoxA gene" S_feature complement(3249417..3249485) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3249472..3249491) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3249485) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3249487..3249672) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3249504..3249508) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3249603..3249608 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3249624..3249642 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3249629 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3249663..3249682) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3249672) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3249674..3249783) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3249697..3249701) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3249739 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3249768..3249787) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3249783) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3249803..3249807) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3249861..3249879) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3249866..3249872 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3249878) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3249887..3249905 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3249890 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3249895..3249900) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3249932..3250177 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" /label="ywzA CDS" gene 3249932..3250177 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /label="ywzA gene" downshifts 3250159 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3250248..3251789) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" /label="galT CDS" gene complement(3250248..3251789) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /label="galT gene" downshifts complement(3250277) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3251793..3252965) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" /label="galK CDS" gene complement(3251793..3252965) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /label="galK gene" promotor_-10 complement(3252983..3253001) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3253005) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3253016..3253022) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3253046..3253429) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" /label="ywcD CDS" gene complement(3253046..3253429) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /label="ywcD gene" CDS complement(3253447..3254118) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" /label="slrC CDS" gene complement(3253447..3254118) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /label="slrC gene" promotor_-10 complement(3254140..3254159) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3254149) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3254175..3254178) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3254259..3254262 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3254277..3254296 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3254286..3254473 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3254286 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="upshifts" CDS 3254474..3254632 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" /label="slrA CDS" gene 3254474..3254632 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /label="slrA gene" S_feature 3254633..3255017 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3254998..3255003 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3255019..3255037 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3255019 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="upshifts" CDS 3255075..3255383 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" /label="vbfB CDS" gene 3255075..3255383 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /label="vbfB gene" downshifts complement(3255161) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3255165..3255265) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3255205) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3255380..3256921 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" /label="vbfA CDS" gene 3255380..3256921 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /label="vbfA gene" downshifts 3256912 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3256952..3257554) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" /label="ywbO CDS" gene complement(3256952..3257554) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /label="ywbO gene" downshifts complement(3256966) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3257555..3257836) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3257837..3259087) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" /label="efeB CDS" gene complement(3257837..3259087) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /label="efeB gene" downshifts complement(3257933) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" /label="downshifts" CDS complement(3259106..3260263) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" /label="efeM CDS" gene complement(3259106..3260263) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /label="efeM gene" misc_feature complement(3259179..3259198) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3259206) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3260260..3261705) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" /label="efeU CDS" gene complement(3260260..3261705) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /label="efeU gene" promotor_-10 complement(3261739..3261758) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3261749) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3261772..3261779) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3261862..3262530) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" /label="thiE CDS" gene complement(3261862..3262530) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /label="thiE gene" downshifts complement(3261871) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3262527..3263345) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" /label="thiM CDS" gene complement(3262527..3263345) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /label="thiM gene" CDS complement(3263353..3264258) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" /label="cidR CDS" gene complement(3263353..3264258) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /label="cidR gene" misc_feature complement(3263993..3264012) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3264004) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3264299..3264318) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3264309..3264316 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3264320) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" upshifts 3264328 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3264330..3264349 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3264334..3264341) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3264364..3264750 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" /label="cidA CDS" gene 3264364..3264750 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /label="cidA gene" CDS 3264732..3265409 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" /label="cidB CDS" gene 3264732..3265409 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /label="cidB gene" downshifts 3265381 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3265453..3265460 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3265471 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3265474..3265493 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3265513..3266712 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" /label="ywbF CDS" gene 3265513..3266712 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /label="ywbF gene" CDS 3266746..3266943 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" /label="ywbE CDS" gene 3266746..3266943 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /label="ywbE gene" downshifts 3266922 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(3266978..3268168) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" /label="rlmI CDS" gene complement(3266978..3268168) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /label="rlmI gene" downshifts complement(3266993) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" /label="downshifts" downshifts complement(3267077) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" misc_feature complement(3268192..3268211) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3268208) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3268228..3268235 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3268244 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3268249..3268268 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3268289..3268669 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" /label="glxA CDS" gene 3268289..3268669 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /label="glxA gene" downshifts 3268567 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" /label="downshifts" downshifts 3268638 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" downshifts complement(3268714) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 3268729..3268730 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs27_020" promotor_-35 <3268730..3268733 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3268748..3268767 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3268767 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3268979..3268986 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3268999..3269018 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3268999 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="upshifts" CDS 3269051..3270430 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" /label="sacX CDS" gene 3269051..3270430 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /label="sacX gene" S_feature complement(3270139..3271342) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3270484..3271326 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" /label="sacY CDS" gene 3270484..3271326 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /label="sacY gene" CDS complement(3271377..3272237) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" /label="gspA CDS" gene complement(3271377..3272237) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /label="gspA gene" downshifts complement(3271387) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" /label="downshifts" downshifts 3272221 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3272259..3272277) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3272277) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3272292..3272298) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3272347..3273060) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" /label="ywaF CDS" gene complement(3272347..3273060) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /label="ywaF gene" promotor_-35 3272462..3272463 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3272483..3272500 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3272485 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3273088..3273099) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3273089) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3273114..3273120) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3273135..3273141 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3273156..3273175 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3273166 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 3273211..3273726 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" /label="tyrZR CDS" gene 3273211..3273726 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /label="tyrZR gene" misc_RNA 3273727..3273933 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboYB RNA" gene 3273727..3273933 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /label="tboYB gene" downshifts 3273893 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3273975..3275216 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" /label="tyrZ CDS" gene 3273975..3275216 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /label="tyrZ gene" promotor_-35 3275307..3275315 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3275326..3275344 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3275337 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="upshifts" CDS 3275372..3276739 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" /label="eapD CDS" gene 3275372..3276739 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /label="eapD gene" downshifts 3276716 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(3276769..3277401) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" /label="relQ CDS" gene complement(3276769..3277401) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /label="relQ gene" downshifts complement(3276787) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3277437..3277452) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3277445) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3277465..3277473) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3277543..3278478) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" /label="menA CDS" gene complement(3277543..3278478) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /label="menA gene" downshifts complement(3277555) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3278222..3278231 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3278245..3278264 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3278249 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3278479..3278566) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3278549..3278568) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3278566) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3278584..3278588) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3278611..3278623) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3278611) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3278638..3278644) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3278641..3278775) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" /label="hypothetical protein CDS" gene complement(3278641..3278775) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /label="gene" promotor_-35 3278722..3278729 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3278743..3278762 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3278752 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="upshifts" S_feature 3278755..3278859 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3278854..3278863 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3278861 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3278875..3278890 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3278897) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3278899..3278913) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3278925..3279074 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" /label="ywzH CDS" gene 3278925..3279074 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /label="ywzH gene" CDS 3279092..3280603 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" /label="dltA CDS" gene 3279092..3280603 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /label="dltA gene" CDS 3280600..3281787 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" /label="dltB CDS" gene 3280600..3281787 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /label="dltB gene" CDS 3281804..3282040 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" /label="dltC CDS" gene 3281804..3282040 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /label="dltC gene" CDS 3282040..3283218 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" /label="dltD CDS" gene 3282040..3283218 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /label="dltD gene" S_feature 3283219..3283308 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3283309..3284067 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" /label="dltE CDS" gene 3283309..3284067 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /label="dltE gene" downshifts 3284035 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature complement(3284069..3285296) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3284115..3284122 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3284136..3284155 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3284149 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="upshifts" CDS 3284208..3285299 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" /label="ilvK CDS" gene 3284208..3285299 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /label="ilvK gene" downshifts 3285201 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 3285289 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3285333..3286661) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" /label="licH CDS" gene complement(3285333..3286661) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /label="licH gene" downshifts complement(3285341) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" CDS complement(3286658..3286990) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" /label="licA CDS" gene complement(3286658..3286990) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /label="licA gene" CDS complement(3287009..3288367) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" /label="licC CDS" gene complement(3287009..3288367) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /label="licC gene" CDS complement(3288383..3288691) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" /label="licB CDS" gene complement(3288383..3288691) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /label="licB gene" promotor_-10 complement(3288736..3288755) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3288752) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3288769..3288775) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3288820) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3288820..3290745) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" /label="licR CDS" gene complement(3288820..3290745) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /label="licR gene" promotor_-35 3289483..3289492 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3289506..3289525 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3289514 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3290818..3290835) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3290842) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="upshifts" promotor_-35 complement(3290850..3290857) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3290908..3291066) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" /label="yxzF CDS" gene complement(3290908..3291066) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /label="yxzF gene" downshifts complement(3290935) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3291095..3291685) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" /label="aag CDS" gene complement(3291095..3291685) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /label="aag gene" promotor_-10 complement(3291713..3291731) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3291724) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3291745..3291751) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3291754..3291760 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3291776..3291794 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3291779 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="upshifts" CDS 3291814..3293457 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" /label="katX CDS" gene 3291814..3293457 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /label="katX gene" S_feature complement(3291951..3293500) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3293452 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3293502..3293593) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3293504..3293510 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3293518 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3293525..3293544 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3293545) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" /label="downshifts" CDS 3293562..3294764 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" /label="yxlH CDS" gene 3293562..3294764 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /label="yxlH gene" S_feature complement(3293595..3294760) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3293638) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS complement(3294761..3295537) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" /label="yxlG CDS" gene complement(3294761..3295537) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /label="yxlG gene" CDS complement(3295534..3296421) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" /label="yxlF CDS" gene complement(3295534..3296421) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /label="yxlF gene" CDS complement(3296428..3296616) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" /label="yxlE CDS" gene complement(3296428..3296616) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /label="yxlE gene" CDS complement(3296613..3296819) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" /label="yxlD CDS" gene complement(3296613..3296819) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /label="yxlD gene" CDS complement(3296816..3297136) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" /label="yxlC CDS" gene complement(3296816..3297136) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /label="yxlC gene" promotor_-35 3296949..3296958 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3296971..3296990 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3296973 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3297129..3297665) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" /label="sigY CDS" gene complement(3297129..3297665) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /label="sigY gene" upshifts complement(3297693) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3297694..3297709) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3297721..3297730) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3297796..3297803 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3297817..3297836 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3297826 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="upshifts" CDS 3297877..3299250 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" /label="yxlA CDS" gene 3297877..3299250 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /label="yxlA gene" S_feature complement(3298157..3298699) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3298687..3298706) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3298699) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3298721..3298728) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3299085 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3299265..3300095) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" /label="nnrA CDS" gene complement(3299265..3300095) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /label="nnrA gene" downshifts complement(3299271) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3300114..3300132) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3300129) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3300147..3300153) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3300173) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3300175..3300194) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3300181..3301908) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" /label="cydD CDS" gene complement(3300181..3301908) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /label="cydD gene" downshifts complement(3300280) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" /label="downshifts" CDS complement(3301905..3303608) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" /label="cydC CDS" gene complement(3301905..3303608) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /label="cydC gene" CDS complement(3303608..3304624) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" /label="cydB CDS" gene complement(3303608..3304624) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /label="cydB gene" promotor_-10 complement(3304498..3304516) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3304507) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3304532..3304537) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3304608..3306014) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" /label="cydA CDS" gene complement(3304608..3306014) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /label="cydA gene" S_feature complement(3306015..3306223) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3306206..3306225) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3306223) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3306225..3306333) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3306239..3306244) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3306330..3306349) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3306345) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="upshifts" promotor_-35 complement(3306363..3306370) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3306491..3306498 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3306508 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3306513..3306531 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3306570..3307922 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" /label="cimH CDS" gene 3306570..3307922 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /label="cimH gene" S_feature complement(3307521..3310003) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3307907 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3307998..3308017 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3308004 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="upshifts" CDS 3308044..3309732 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" /label="yxkI CDS" gene 3308044..3309732 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /label="yxkI gene" promotor_-35 3309730..3309739 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3309751..3309766 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3309755 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="upshifts" CDS 3309790..3309990 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" /label="yxzE CDS" gene 3309790..3309990 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /label="yxzE gene" S_feature 3309991..3310935 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3310004..3310843) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" /label="yxkH CDS" gene complement(3310004..3310843) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /label="yxkH gene" promotor_-10 complement(3310869..3310887) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3310887) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3310900..3310907) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3310902 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(3310950..3312047) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" /label="msmX CDS" gene complement(3310950..3312047) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /label="msmX gene" downshifts complement(3310951) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3312080..3312099) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3312097) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3312099..3312167) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3312112..3312119) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3312168..3313061) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" /label="yxkF CDS" gene complement(3312168..3313061) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /label="yxkF gene" promotor_-10 complement(3313088..3313107) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3313107) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3313121..3313128) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3313135..3313140 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3313156..3313174 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3313165 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3313182..3313188 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3313203..3313221 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3313209 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="upshifts" CDS 3313245..3314702 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" /label="aldY CDS" gene 3313245..3314702 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /label="aldY gene" promotor_-10 complement(3314128..3314146) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3314143) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3314161..3314166) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3314683 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 3314727 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3314744..3315580) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" /label="gdnE CDS" gene complement(3314744..3315580) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /label="gdnE gene" downshifts complement(3314762) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" misc_RNA complement(3315657..3315759) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" /label="gdwB RNA" gene complement(3315657..3315759) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /label="gdwB gene" downshifts complement(3315683) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3315785..3315804) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3315796) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3315798..3316539) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3315818..3315824) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3315876..3315883 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3315896..3315914 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3315905 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" S_feature 3315915..3316000 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3315976..3315983 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3315997..3316016 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3316002 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" CDS 3316148..3316690 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" /label="yxkC CDS" gene 3316148..3316690 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /label="yxkC gene" promotor_-10 complement(3316515..3316534) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3316539) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3316548..3316557) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3316680 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" S_feature 3316725..3317047 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3316765..3317784) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" /label="galE CDS" gene complement(3316765..3317784) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /label="galE gene" downshifts complement(3316783) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3317810..3317829) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3317824) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3317844..3317847) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3317899..3318405) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" /label="yxkA CDS" gene complement(3317899..3318405) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /label="yxkA gene" promotor_-10 complement(3318411..3318430) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3318433) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3318435..3318438 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3318444..3318450) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3318453..3318472 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3318456 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="upshifts" CDS 3318535..3319410 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" /label="yxjO CDS" gene 3318535..3319410 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /label="yxjO gene" S_feature complement(3318785..3318873) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3318807) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3318833..3318933) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3318873) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="upshifts" CDS 3319488..3319961 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" /label="yxjN CDS" gene 3319488..3319961 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /label="yxjN gene" CDS 3319979..3321199 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" /label="yxjM CDS" gene 3319979..3321199 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /label="yxjM gene" CDS 3321186..3321842 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" /label="yxjL CDS" gene 3321186..3321842 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /label="yxjL gene" promotor_-35 3321840..3321845 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3321859..3321878 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3321862 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="upshifts" CDS 3321892..3323124 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" /label="pepT CDS" gene 3321892..3323124 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /label="pepT gene" downshifts complement(3321909) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" downshifts 3323109 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 3323170..3323179 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3323192..3323207 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3323194..3323416 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3323194 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3323373 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" /label="downshifts" promotor_-35 3323427..3323433 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3323446..3323546 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3323446 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="upshifts" promotor_-10 3323448..3323466 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3323525..3323532 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3323546..3323564 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3323548..3323645 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3323548 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" CDS 3323646..3323909 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" /label="yxjJ CDS" gene 3323646..3323909 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /label="yxjJ gene" promotor_-35 3323673..3323676 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3323691..3323710 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3323703 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3323857 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3323901 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 3323976..3323985 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3323991 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3323997..3324012 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3324038..3324526 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" /label="yxjI CDS" gene 3324038..3324526 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /label="yxjI gene" promotor_-35 3324531..3324538 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3324552..3324571 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3324562 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3324592..3324698 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswI RNA" gene 3324592..3324698 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /label="mswI gene" downshifts 3324693 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3324781..3325914 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" /label="yxjH CDS" gene 3324781..3325914 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /label="yxjH gene" S_feature complement(3325054..3325297) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3325292..3325311) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3325301) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3325326..3325333) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3325920..3325927 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3325942..3325961 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3325948 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3325983..3326089 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswJ RNA" gene 3325983..3326089 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /label="mswJ gene" downshifts 3326036 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 3326090..3326166 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3326167..3327303 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" /label="yxjG CDS" gene 3326167..3327303 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /label="yxjG gene" downshifts 3327290 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3327356..3328129) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" /label="yxjF CDS" gene complement(3327356..3328129) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /label="yxjF gene" downshifts complement(3327366) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3328146..3328796) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" /label="scoB CDS" gene complement(3328146..3328796) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /label="scoB gene" CDS complement(3328793..3329509) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" /label="scoA CDS" gene complement(3328793..3329509) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /label="scoA gene" CDS complement(3329533..3330951) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" /label="yxjC CDS" gene complement(3329533..3330951) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /label="yxjC gene" promotor_-10 complement(3330119..3330137) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3330138) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3330153..3330158) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3330952..3331036) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3331020..3331038) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3331036) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3331054..3331059) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3331105..3331953) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" /label="rlmA CDS" gene complement(3331105..3331953) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /label="rlmA gene" downshifts complement(3331115) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(3331954..3332139) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3332128..3332147) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3332139) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3332141..3332866) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3332163..3332167) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3332301..3332308 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3332321..3332340 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3332330 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3332340..3332442 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswB RNA" gene 3332340..3332442 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /label="gswB gene" S_feature 3332443..3332546 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3332518..3332524 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3332538..3332549 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3332548 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="upshifts" CDS 3332569..3333762 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" /label="nupG CDS" gene 3332569..3333762 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /label="nupG gene" promotor_-10 complement(3332853..3332871) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3332869) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3332884..3332891) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3333538 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3333758 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3333804..3334232) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" /label="yxiTc CDS" gene complement(3333804..3334232) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo /label="yxiTc gene" CDS complement(3334233..3334475) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" /label="yxiTn CDS" gene complement(3334233..3334475) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo /label="yxiTn gene" S_feature complement(3334476..3334539) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3334528..3334543) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3334539) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3334555..3334564) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3334572 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(3334620..3334910) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" /label="yxiS CDS" gene complement(3334620..3334910) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /label="yxiS gene" downshifts complement(3334626) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3334935..3334954) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3334952) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3334960..3337020) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" /label="katE CDS" gene complement(3334960..3337020) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /label="katE gene" promotor_-35 complement(3334968..3334975) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3337049..3337067) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3337053) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3337082..3337088) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3337113..3337118 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3337132 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3337134..3337152 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3337146..3337220 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3337221..3338501 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" /label="citH CDS" gene 3337221..3338501 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /label="citH gene" S_feature 3338502..3338641 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3338598 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3338659..3339387) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" /label="bglS CDS" gene complement(3338659..3339387) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /label="bglS gene" downshifts complement(3338676) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3339418..3339437) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3339429) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3339451..3339458) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3339575..3339682) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3339618) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" /label="downshifts" CDS complement(3339683..3340516) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" /label="licT CDS" gene complement(3339683..3340516) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /label="licT gene" promotor_-10 complement(3340547..3340566) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3340566) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3340580..3340587) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3340612..3341292) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" /label="yxiP CDS" gene complement(3340612..3341292) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /label="yxiP gene" promotor_-10 complement(3341339..3341358) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3341348) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="upshifts" promotor_-35 complement(3341372..3341379) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3341440..3341443 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3341458..3341477 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3341458 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="upshifts" CDS 3341499..3342785 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" /label="yxiO CDS" gene 3341499..3342785 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /label="yxiO gene" promotor_-10 complement(3342230..3342248) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3342238) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3342262..3342269) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3342756 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3342804..3344243) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" /label="deaD CDS" gene complement(3342804..3344243) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /label="deaD gene" downshifts complement(3342827) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" /label="downshifts" misc_feature complement(3344267..3344286) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3344284) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3344325..3345473) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" /label="yxiM CDS" gene complement(3344325..3345473) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /label="yxiM gene" promotor_-10 complement(3345500..3345516) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3345516) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3345518..3345602) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3345531..3345536) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3345603..3345791) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" /label="yxzI CDS" gene complement(3345603..3345791) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo /label="yxzI gene" CDS complement(3345822..3345953) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " /label="yxzJ CDS" gene complement(3345822..3345953) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /label="yxzJ gene" CDS complement(3345965..3346426) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" /label="yxiK CDS" gene complement(3345965..3346426) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /label="yxiK gene" CDS complement(3346442..3346738) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" /label="yxiJ CDS" gene complement(3346442..3346738) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /label="yxiJ gene" CDS complement(3346766..3347254) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" /label="yxiI CDS" gene complement(3346766..3347254) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /label="yxiI gene" CDS complement(3347272..3347724) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" /label="yxzG CDS" gene complement(3347272..3347724) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /label="yxzG gene" S_feature complement(3347725..3347793) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3347794..3348123) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" /label="yxiH CDS" gene complement(3347794..3348123) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /label="yxiH gene" S_feature complement(3348124..3348245) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3348246..3348662) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" /label="yxiG CDS" gene complement(3348246..3348662) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /label="yxiG gene" CDS complement(3348713..3349081) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" /label="yxzC CDS" gene complement(3348713..3349081) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /label="yxzC gene" CDS complement(3349075..3349545) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" /label="yxiF CDS" gene complement(3349075..3349545) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /label="yxiF gene" S_feature complement(3349546..3349870) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3349871..3350299) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" /label="wapI CDS" gene complement(3349871..3350299) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /label="wapI gene" CDS complement(3350361..3357365) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" /label="wapA CDS" gene complement(3350361..3357365) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /label="wapA gene" misc_feature 3357372..3357386 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3357386 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3357396..3357415) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3357411) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3357430..3357437) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3357527..3358462) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" /label="yxxF CDS" gene complement(3357527..3358462) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /label="yxxF gene" downshifts complement(3357748) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(3358463..3358583) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3358614..3359060) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" /label="yxiE CDS" gene complement(3358614..3359060) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /label="yxiE gene" downshifts complement(3358628) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3359097..3359116) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3359104) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3359130..3359137) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3359163..3360572) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" /label="bglH CDS" gene complement(3359163..3360572) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /label="bglH gene" CDS complement(3360595..3362424) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" /label="bglP CDS" gene complement(3360595..3362424) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /label="bglP gene" promotor_no_box complement(3362416..3362516) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3362456) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="upshifts" S_feature complement(3362458..3362650) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3362631..3362650) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3362650) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3362652..3362785) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3362663..3362670) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3362807..3363115) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" /label="yxxE CDS" gene complement(3362807..3363115) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /label="yxxE gene" downshifts complement(3362830) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" /label="downshifts" CDS complement(3363161..3363604) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" /label="rtbE CDS" gene complement(3363161..3363604) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /label="rtbE gene" CDS complement(3363601..3365310) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" /label="rtbD CDS" gene complement(3363601..3365310) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /label="rtbD gene" misc_feature complement(3364472..3364491) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3364480) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="upshifts" CDS complement(3365330..3365599) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" /label="yxiC CDS" gene complement(3365330..3365599) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /label="yxiC gene" CDS complement(3365611..3365976) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" /label="yxiB CDS" gene complement(3365611..3365976) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /label="yxiB gene" S_feature complement(3365977..3366042) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3366029..3366048) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3366042) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3366063..3366066) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3366283..3367692) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" /label="abnB CDS" gene complement(3366283..3367692) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /label="abnB gene" downshifts complement(3366306) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" /label="downshifts" S_feature complement(3367693..3367802) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3367826..3367990) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" /label="yxzL CDS" gene complement(3367826..3367990) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /label="yxzL gene" promotor_-10 complement(3367875..3367893) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3367890) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3367904..3367912) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3368182..3368201) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3368198) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3368214..3368221) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3368230..3368237 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3368252..3368271 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3368255 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="upshifts" CDS 3368309..3368755 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" /label="hutP CDS" gene 3368309..3368755 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /label="hutP gene" downshifts 3368760 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" /label="downshifts" CDS 3368868..3370394 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" /label="hutH CDS" gene 3368868..3370394 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /label="hutH gene" CDS 3370391..3372049 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" /label="hutU CDS" gene 3370391..3372049 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /label="hutU gene" CDS 3372062..3373327 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" /label="hutI CDS" gene 3372062..3373327 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /label="hutI gene" CDS 3373320..3374279 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" /label="hutG CDS" gene 3373320..3374279 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /label="hutG gene" S_feature 3374280..3374354 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3374355..3375782 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" /label="hutM CDS" gene 3374355..3375782 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /label="hutM gene" downshifts 3375778 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3375826..3377127) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" /label="pdp CDS" gene complement(3375826..3377127) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /label="pdp gene" downshifts complement(3375843) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3377157..3378338) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" /label="nupC CDS" gene complement(3377157..3378338) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /label="nupC gene" S_feature complement(3378339..3378418) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3378419..3379090) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" /label="deoC CDS" gene complement(3378419..3379090) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /label="deoC gene" promotor_-35 3379039..3379042 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3379057 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3379058..3379077 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3379118..3379137) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3379133) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3379151..3379158) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3379196..3380137) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" /label="deoR CDS" gene complement(3379196..3380137) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /label="deoR gene" promotor_-10 complement(3380182..3380201) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3380188) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3380190..3380270) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3380217..3380220) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 3380286..3380287 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_018" promotor_-35 3380383..3380389 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3380405..3380423 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3380415 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="upshifts" CDS 3380477..3381862 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" /label="csbC CDS" gene 3380477..3381862 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /label="csbC gene" downshifts 3381848 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 3381893..3382443 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3381904..3383784) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" /label="htpG CDS" gene complement(3381904..3383784) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /label="htpG gene" downshifts complement(3381910) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" S_feature complement(3383785..3383882) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3383873..3383892) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3383882) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3383907..3383914) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3383952..3384203) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" /label="yxcA CDS" gene complement(3383952..3384203) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /label="yxcA gene" downshifts complement(3383970) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" misc_feature complement(3384225..3384244) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3384234) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="upshifts" promotor_-35 3384267..3384273 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3384287..3384305 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3384288 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="upshifts" CDS 3384320..3385141 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" /label="yxbG CDS" gene 3384320..3385141 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /label="yxbG gene" downshifts 3385125 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" /label="downshifts" CDS complement(3385170..3386312) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" /label="yxbF CDS" gene complement(3385170..3386312) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /label="yxbF gene" downshifts complement(3385180) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3386313..3386412) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3386400..3386419) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3386411) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3386433..3386440) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3386455..3387792 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" /label="aldX CDS" gene 3386455..3387792 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /label="aldX gene" S_feature complement(3387197..3387797) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3387831..3388310) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " /label="yxbD CDS" gene complement(3387831..3388310) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /label="yxbD gene" downshifts complement(3387842) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3388390..3389382) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" /label="yxbC CDS" gene complement(3388390..3389382) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /label="yxbC gene" downshifts complement(3388414) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" /label="downshifts" downshifts 3389372 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3389405..3389424) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3389423) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3389439..3389446) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3389445..3389452 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3389466..3389890 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3389466 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3389467..3389486 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3389472..3389884 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="srlX RNA" gene 3389472..3389884 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /label="srlX gene" upshifts complement(3389492) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3389502..3389516) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3389524..3389528) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3389856 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" /label="downshifts" CDS 3389891..3390625 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" /label="yxbB CDS" gene 3389891..3390625 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /label="yxbB gene" CDS 3390625..3390894 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" /label="yxbA CDS" gene 3390625..3390894 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /label="yxbA gene" CDS 3390898..3391380 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" /label="yxnB CDS" gene 3390898..3391380 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /label="yxnB gene" CDS 3391401..3393644 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" /label="asnH CDS" gene 3391401..3393644 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /label="asnH gene" CDS 3393641..3394840 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" /label="yxaM CDS" gene 3393641..3394840 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /label="yxaM gene" promotor_-10 complement(3394596..3394614) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3394618) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3394629..3394635) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3394831 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts complement(3394904) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3394904..3396136) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" /label="yxaL CDS" gene complement(3394904..3396136) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /label="yxaL gene" promotor_-10 complement(3396168..3396187) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3396180) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3396201..3396206) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3396237..3396662) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" /label="yxaJ CDS" gene complement(3396237..3396662) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /label="yxaJ gene" promotor_-10 complement(3396690..3396709) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3396704) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3396722..3396728) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3396854..3396861 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3396871 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3396876..3396895 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3396919..3397374 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" /label="yxaI CDS" gene 3396919..3397374 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /label="yxaI gene" downshifts 3397312 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" S_feature 3397375..3397988 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3397404..3398612) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" /label="yxaH CDS" gene complement(3397404..3398612) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /label="yxaH gene" downshifts complement(3397431) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" /label="downshifts" S_feature complement(3398613..3398719) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3398720..3399733) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" /label="qdoI CDS" gene complement(3398720..3399733) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /label="qdoI gene" S_feature complement(3399734..3399807) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3399792..3399811) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3399807) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3399824..3399831) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3399827..3400402) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" /label="qdoR CDS" gene complement(3399827..3400402) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /label="qdoR gene" downshifts complement(3399851) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3400431..3400450) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3400445) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3400465..3400472) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3400473..3400479 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3400494..3400512 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3400501 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="upshifts" CDS 3400533..3401603 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" /label="yxnA CDS" gene 3400533..3401603 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /label="yxnA gene" downshifts 3401601 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3401660..3402091) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" /label="yxaD CDS" gene complement(3401660..3402091) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /label="yxaD gene" promotor_-35 3402121..3402128 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3402142..3402161 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3402151..3402317 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3402151 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3402203..3402222) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3402223) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3402237..3402244) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3402318..3402722 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" /label="yxzK CDS" gene 3402318..3402722 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /label="yxzK gene" S_feature complement(3402339..3403391) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3402692..3403384 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" /label="yxaC CDS" gene 3402692..3403384 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /label="yxaC gene" CDS complement(3403424..3404455) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" /label="yxaB CDS" gene complement(3403424..3404455) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /label="yxaB gene" downshifts complement(3403436) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-35 3404422..3404425 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3404438 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3404442..3404461 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3404492..3404510) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3404510) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3404525..3404531) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3404548..3405696) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" /label="glxK CDS" gene complement(3404548..3405696) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /label="glxK gene" promotor_-10 complement(3405735..3405754) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3405746) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3405765..3405772) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3405818..3405825 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3405839..3405858 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3405846 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3405892..3406623 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" /label="gntR CDS" gene 3405892..3406623 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /label="gntR gene" CDS 3406616..3408157 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" /label="gntK CDS" gene 3406616..3408157 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /label="gntK gene" CDS 3408186..3409532 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" /label="gntP CDS" gene 3408186..3409532 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /label="gntP gene" promotor_-35 3408985..3408989 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3409005..3409024 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3409014 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3409555..3410961 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" /label="gntZ CDS" gene 3409555..3410961 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /label="gntZ gene" downshifts 3410950 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3411058..3411077 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3411060..3411351 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3411060 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="upshifts" promotor_-35 3411324..3411331 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3411346..3411365 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3411353 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3411375..3411382 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3411397..3411416 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3411400) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3411403..3411417) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3411412 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3411425..3411429) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3411425..3411988 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" /label="ahpC CDS" gene 3411425..3411988 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /label="ahpC gene" CDS 3412002..3413531 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" /label="ahpF CDS" gene 3412002..3413531 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /label="ahpF gene" downshifts complement(3413358) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" /label="downshifts" downshifts 3413524 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3413557..3413640) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3413600) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3413641..3415080) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" /label="bglA CDS" gene complement(3413641..3415080) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /label="bglA gene" CDS complement(3415094..3415324) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" /label="ptsJ CDS" gene complement(3415094..3415324) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /label="ptsJ gene" S_feature complement(3415325..3415536) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3415533..3415552) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3415538) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3415567..3415574) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3415600..3415607 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3415618..3415637 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3415633 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="upshifts" CDS 3415668..3416378 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" /label="yydK CDS" gene 3415668..3416378 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /label="yydK gene" CDS 3416406..3416564 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" /label="yyzN CDS" gene 3416406..3416564 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /label="yyzN gene" downshifts 3416641 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3416695..3417417) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" /label="liaM CDS" gene complement(3416695..3417417) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /label="liaM gene" downshifts complement(3416707) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-35 3417318..3417321 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3417337..3417341 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3417352 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3417438..3418067) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" /label="liaL CDS" gene complement(3417438..3418067) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /label="liaL gene" S_feature complement(3418068..3418216) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3418217..3418975) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" /label="liaK CDS" gene complement(3418217..3418975) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /label="liaK gene" promotor_-10 complement(3418665..3418684) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3418681) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3418697..3418704) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3418956..3419915) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" /label="liaE CDS" gene complement(3418956..3419915) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /label="liaE gene" downshifts 3419904 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3419951..3419954 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3419959 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3419973..3420122) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" /label="liaD CDS" gene complement(3419973..3420122) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /label="liaD gene" downshifts complement(3419980) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" /label="downshifts" misc_feature 3420031..3420048 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3420036 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3420117 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3420143..3420162) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3420164) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3420177..3420184) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3420457..3420464 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3420479..3420498 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3420483 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="upshifts" CDS 3420594..3422519 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" /label="fbp CDS" gene 3420594..3422519 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /label="fbp gene" S_feature 3422520..>3422549 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" SCAR 3422549..3422550 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs27_025" downshifts 3422559 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3422807..3423697) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" /label="argI CDS" gene complement(3422807..3423697) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /label="argI gene" downshifts complement(3422813) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" downshifts complement(3422875) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" /label="downshifts" CDS complement(3423771..3425174) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" /label="rocE CDS" gene complement(3423771..3425174) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /label="rocE gene" S_feature complement(3425175..3425396) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3425397..3426602) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" /label="rocD CDS" gene complement(3425397..3426602) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /label="rocD gene" misc_feature complement(3426659..3426677) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3426662) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3426772..3426777 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3426792..3426811 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3426807 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="upshifts" CDS 3426843..3428228 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" /label="rocR CDS" gene 3426843..3428228 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /label="rocR gene" CDS complement(3428210..3428398) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" /label="yyzO CDS" gene complement(3428210..3428398) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo /label="yyzO gene" CDS complement(3428515..3428643) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" /label="hypothetical protein CDS" gene complement(3428515..3428643) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /label="gene" downshifts 3428567 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS complement(3428663..3429865) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" /label="htrC CDS" gene complement(3428663..3429865) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /label="htrC gene" downshifts complement(3428687) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3429897..3429908) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3429897) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3429923..3429929) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3429947..3430741) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" /label="walJ CDS" gene complement(3429947..3430741) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /label="walJ gene" CDS complement(3430763..3431605) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" /label="walI CDS" gene complement(3430763..3431605) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /label="walI gene" CDS complement(3431592..3432959) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /modified_by="User" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYTNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" /label="Delta6_BSU_40390_SNPvariant" gene complement(3431592..3432959) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /modified_by="User" /label="Delta6_BSU_40390_SNPvariant" Polymorphism join(3432186,3432188) /Source="geneious" /ID="SNP_BsDelta6_4151091_4151091" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="N -> T" /CDS_Position=773 /Change="T -> G" /Codon_Change="AAC -> ACC" /Coverage=184 /locus_tag="BSU_40390" /Protein_Effect="Substitution" /Reference_Frequency="0.5%" /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="Delta6_BSU_40390_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(3432949..3434784) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" /label="walK CDS" gene complement(3432949..3434784) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /label="walK gene" CDS complement(3434792..3435499) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" /label="walR CDS" gene complement(3434792..3435499) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /label="walR gene" S_feature complement(3435500..3435596) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3435584..3435603) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3435596) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3435598..3435790) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3435619..3435622) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3435790) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="upshifts" misc_feature complement(3435800..3435819) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3435882) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" tRNA complement(3435883..3435955) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Phe tRNA" gene complement(3435883..3435955) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /label="trnY-Phe gene" tRNA complement(3435991..3436067) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Asp tRNA" gene complement(3435991..3436067) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /label="trnY-Asp gene" S_feature complement(3436068..3436148) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3436149..3436220) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Glu tRNA" gene complement(3436149..3436220) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /label="trnY-Glu gene" tRNA complement(3436230..3436305) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Lys tRNA" gene complement(3436230..3436305) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /label="trnY-Lys gene" misc_feature 3436277..3436293 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3436290 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3436306..3436402) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3436386..3436405) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3436402) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3436419..3436426) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3436436..3436537) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3436476) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3436530..3437822) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" /label="purA CDS" gene complement(3436530..3437822) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /label="purA gene" downshifts complement(3436541) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3437862..3437881) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3437882) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3437896..3437903) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3438028..3438447) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" /label="yycE CDS" gene complement(3438028..3438447) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /label="yycE gene" promotor_-10 complement(3438445..3438456) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3438456) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3438471..3438477) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3438568..3439932) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" /label="dnaC CDS" gene complement(3438568..3439932) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /label="dnaC gene" downshifts complement(3438588) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3438632) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3439963..3439982) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3439977) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3439997..3439999) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3440044..3440050 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3440065..3440083 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3440067 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="upshifts" CDS 3440102..3440302 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" /label="yycD CDS" gene 3440102..3440302 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /label="yycD gene" downshifts 3440272 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" /label="downshifts" S_feature 3440317..3440638 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3440350..3440553) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" /label="yyzB CDS" gene complement(3440350..3440553) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /label="yyzB gene" S_feature complement(3440554..3440854) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3440619..3440622 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3440637..3440656 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3440640 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="upshifts" CDS 3440674..3440814 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" /label="yycC CDS" gene 3440674..3440814 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /label="yycC gene" S_feature 3440815..3440886 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3440862) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3440865..3440879) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3440887..3440891) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3440887..3442095 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" /label="yycB CDS" gene 3440887..3442095 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /label="yycB gene" downshifts 3442076 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 3442200..3444257 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" /label="yycA CDS" gene 3442200..3444257 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /label="yycA gene" downshifts 3444122 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(3444294..3444743) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" /label="rplI CDS" gene complement(3444294..3444743) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /label="rplI gene" downshifts complement(3444308) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3444740..3446719) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" /label="gdpP CDS" gene complement(3444740..3446719) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /label="gdpP gene" misc_feature complement(3445221..3445240) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3445224) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3445637..3445644 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3445658..3445676 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3445662..3446328 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3445662 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3446756..3447685) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" /label="yybS CDS" gene complement(3446756..3447685) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /label="yybS gene" S_feature complement(3447686..3447822) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3447804..3447823) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3447822) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3447838..3447843) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3447912..3448061) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" /label="yyzH CDS" gene complement(3447912..3448061) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /label="yyzH gene" downshifts complement(3447938) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3448100..3448119) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3448117) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="upshifts" promotor_-35 complement(3448133..3448139) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3448140..3448149 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3448162..3448181 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3448168 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3448180) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3448182..3448695) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3448184..3448198) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3448207..3448211) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3448207..3448689 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" /label="cotF CDS" gene 3448207..3448689 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /label="cotF gene" downshifts 3448676 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3448719..3449096) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" /label="hypR CDS" gene complement(3448719..3449096) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /label="hypR gene" S_feature 3448721..3449250 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3448740) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3449151..3449170) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3449163) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3449184..3449191) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3449232..3449236 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3449250..3449269 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3449252 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3449277..3449291) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3449280) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3449301..3450230 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" /label="ppaC CDS" gene 3449301..3450230 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /label="ppaC gene" downshifts 3450216 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 3450232..3450233 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_014" CDS complement(3450235..3450789) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" /label="maa CDS" gene complement(3450235..3450789) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /label="maa gene" CDS complement(3450807..3451187) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" /label="yyaH CDS" gene complement(3450807..3451187) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /label="yyaH gene" CDS complement(3451243..3452178) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" /label="ccpB CDS" gene complement(3451243..3452178) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /label="ccpB gene" promotor_-35 3452168..3452177 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3452191..3452210 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3452198 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3452222..3452241) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3452236) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3452237..3452995) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" /label="exoA CDS" gene complement(3452237..3452995) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /label="exoA gene" promotor_-35 complement(3452254..3452261) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3452528..3453031 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 3452990 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS complement(3453060..3453299) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" /label="rpsR CDS" gene complement(3453060..3453299) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /label="rpsR gene" downshifts complement(3453066) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3453134) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" /label="downshifts" CDS complement(3453343..3453861) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" /label="ssbA CDS" gene complement(3453343..3453861) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /label="ssbA gene" CDS complement(3453902..3454189) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" /label="rpsF CDS" gene complement(3453902..3454189) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /label="rpsF gene" S_feature complement(3454190..3454256) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(3454255..3454274) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3454256) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3454288..3454293) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3454300..3455400) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" /label="engD CDS" gene complement(3454300..3455400) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /label="engD gene" promotor_-10 complement(3455448..3455467) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(3455463) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="upshifts" promotor_-35 complement(3455482..3455489) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(3455527..3457530) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" /label="yyaE CDS" gene complement(3455527..3457530) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /label="yyaE gene" CDS complement(3457581..3457787) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" /label="yyzM CDS" gene complement(3457581..3457787) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /label="yyzM gene" promotor_-10 complement(3457749..3457768) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3457774) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3457783..3457789) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3457813..3457832) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(3457824) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="upshifts" promotor_-35 complement(3457849..3457853) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(3457881..3458897) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" /label="yyaD CDS" gene complement(3457881..3458897) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /label="yyaD gene" promotor_-10 complement(3458930..3458948) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3458942) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3458964..3458969) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3459073) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" /label="downshifts" promotor_-35 3459257..3459262 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3459275..3459356 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 3459275 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3459278..3459296 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3459357..3459974 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" /label="sprC CDS" gene 3459357..3459974 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /label="sprC gene" promotor_-35 3459945..3459953 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3459964 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 3459967..3459985 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3459986 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3460013..3460861) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" /label="parB CDS" gene complement(3460013..3460861) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /label="parB gene" downshifts complement(3460033) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" /label="downshifts" CDS complement(3460854..3461615) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" /label="parA CDS" gene complement(3460854..3461615) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /label="parA gene" misc_feature complement(3461649..3461668) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3461667) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3461759) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="upshifts" promotor_-10 complement(3461762..3461770) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(3461784..3461792) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 3461796..3461804 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3461812 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3461816..3461834 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3461863..3462303 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" /label="yyaB CDS" gene 3461863..3462303 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /label="yyaB gene" downshifts 3462252 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3462354..3463205) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" /label="nocA CDS" gene complement(3462354..3463205) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /label="nocA gene" downshifts complement(3462373) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(3463206..3463326) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(3463327..3464046) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" /label="rsmG CDS" gene complement(3463327..3464046) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /label="rsmG gene" CDS complement(3464060..3465946) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" /label="trmF CDS" gene complement(3464060..3465946) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /label="trmF gene" CDS complement(3465967..3467346) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" /label="mnmE CDS" gene complement(3465967..3467346) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /label="mnmE gene" S_feature complement(3467347..3467477) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(3467469..3467488) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3467477) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3467504..3467508) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3467532..3467551) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(3467542) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="upshifts" promotor_-35 complement(3467565..3467572) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 3467632..3467638 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3467643..3469928 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 3467643 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3467653..3467672 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3467657..3468283) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" /label="jag CDS" gene complement(3467657..3468283) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /label="jag gene" downshifts complement(3467674) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3468280..3469065) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" /label="oxaAA CDS" gene complement(3468280..3469065) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /label="oxaAA gene" promotor_-10 complement(3469110..3469129) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3469122) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3469124..3469209) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(3469141..3469147) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3469210..3469560) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" /label="rnpA CDS" gene complement(3469210..3469560) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /label="rnpA gene" S_feature complement(3469561..3469711) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(3469712..3469846) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" /label="rpmH CDS" gene complement(3469712..3469846) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /label="rpmH gene" promotor_no_box 3469870..3469970 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(3469882..3469901) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3469892) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3469894..3469962) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(3469917..3469924) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3469930..>3470063 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 3469930 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3469948..3469967) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3469962) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3469983..3469987) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3470064..3470211 /locus_tag="new_1_148" /created_by="stephanmichalik" /label="S1" S_feature complement(3470087..3470360) /locus_tag="new_24_297_c" /created_by="stephanmichalik" /label="S2" S_feature 3470213..3470472 /locus_tag="new_150_409" /created_by="stephanmichalik" /label="S3" ORIGIN 1 atggaaaata tattagacct gtggaaccaa gcccttgctc aaatcgaaaa aaagttgagc 61 aaaccgagtt ttgagacttg gatgaagtca accaaagccc actcactgca aggcgataca 121 ttaacaatca cggctcccaa tgaatttgcc agagactggc tggagtccag atacttgcat 181 ctgattgcag atactatata tgaattaacc ggggaagaat tgagcattaa gtttgtcatt 241 cctcaaaatc aagatgttga ggactttatg ccgaaaccgc aagtcaaaaa agcggtcaaa 301 gaagatacat ctgattttcc tcaaaatatg ctcaatccaa aatatacttt tgatactttt 361 gtcatcggat ctggaaaccg atttgcacat gctgcttccc tcgcagtagc ggaagcgccc 421 gcgaaagctt acaacccttt atttatctat gggggcgtcg gcttagggaa aacacactta 481 atgcatgcga tcggccatta tgtaatagat cataatcctt ctgccaaagt ggtttatctg 541 tcttctgaga aatttacaaa cgaattcatc aactctatcc gagataataa agccgtcgac 601 ttccgcaatc gctatcgaaa tgttgatgtg cttttgatag atgatattca atttttagcg 661 gggaaagaac aaacccagga agaatttttc catacattta acacattaca cgaagaaagc 721 aaacaaatcg tcatttcaag tgaccggccg ccaaaggaaa ttccgacact tgaagacaga 781 ttgcgctcac gttttgaatg gggacttatt acagatatca caccgcctga tctagaaacg 841 agaattgcaa ttttaagaaa aaaggccaaa gcagagggcc tcgatattcc gaacgaggtt 901 atgctttaca tcgcgaatca aatcgacagc aatattcggg aactcgaagg agcattaatc 961 agagttgtcg cttattcatc tttaattaat aaagatatta atgctgatct ggccgctgag 1021 gcgttgaaag atattattcc ttcctcaaaa ccgaaagtca ttacgataaa agaaattcag 1081 agggtagtag gccagcaatt taatattaaa ctcgaggatt tcaaagcaaa aaaacggaca 1141 aagtcagtag cttttccgcg tcaaatcgcc atgtacttat caagggaaat gactgattcc 1201 tctcttccta aaatcggtga agagtttgga ggacgtgatc atacgaccgt tattcatgcg 1261 catgaaaaaa tttcaaaact gctggcagat gatgaacagc ttcagcagca tgtaaaagaa 1321 attaaagaac agcttaaata gcaggaccgg ggatcaatcg gggaaagtgt gaataacttt 1381 tcggaagtca tacacagtct gtccacatgt ggataggctg tgtttcctgt ctttttcaca 1441 acttatccac aaatccacag gccctactat tacttctact attttttata aatatatata 1501 ttaatacatt atccgttagg aggataaaaa tgaaattcac gattcaaaaa gatcgtcttg 1561 ttgaaagtgt ccaagatgta ttaaaagcag tttcatccag aaccacgatt cccattctga 1621 ctggtattaa aattgttgca tcagatgatg gagtatcctt tacagggagt gactcagata 1681 tttctattga atccttcatt ccaaaagaag aaggagataa agaaatcgtc actattgaac 1741 agcccggaag catcgtttta caggctcgct tttttagtga aattgtaaaa aaattgccga 1801 tggcaactgt agaaattgaa gtccaaaatc agtatttgac gattatccgt tctggtaaag 1861 ctgaatttaa tctaaacgga ctggatgctg atgaatatcc gcacttgccg cagattgaag 1921 agcatcatgc gattcagatc ccaactgatt tgttaaaaaa tctaatcaga caaacagtat 1981 ttgcagtgtc cacctcagaa acacgcccta tcttgacagg tgtaaactgg aaagtggagc 2041 aaagtgaatt attatgcact gcaacggata gccaccgtct tgcattaaga aaggcgaaac 2101 ttgatattcc agaagacaga tcttataacg tcgtgattcc gggaaaaagt ttaactgaac 2161 tcagcaagat tttagatgac aaccaggaac ttgtagatat cgtcatcaca gaaacccaag 2221 ttctgtttaa agcgaaaaac gtcttgttct tctcacggct tctggacggg aattatccag 2281 acacaaccag cctgattccg caagacagca aaacagaaat cattgtgaac acaaaagaat 2341 tccttcaggc cattgatcgt gcatctcttt tagctagaga gggacgcaac aacgttgtaa 2401 aactgtccgc aaaaccggct gaatccattg aaatttcttc caattcgcca gaaatcggta 2461 aagttgtgga agcaattgtt gcggatcaaa ttgaaggtga ggaattaaat atctctttta 2521 gtccaaaata tatgctggat gcactaaagg tgcttgaagg agcagaaata cgcgtaagct 2581 ttacaggcgc aatgagacct ttcttaattc gcacgccgaa tgatgaaacg attgtacagc 2641 ttatccttcc tgtcagaacc tattaatccg atacactgct gccgacccgt cggcagcttt 2701 tctattcggt atctgctccg acaagttttc cctttcccta attcgttttt ttttagtaca 2761 attagatatt agtgatattt gaaagaggtc gatataatgg caaatccgat ttcaattgat 2821 acagagatga ttacactcgg acaattctta aaattagccg atgtgattca gtctggcggt 2881 atggcgaagt ggtttttaag cgagcatgaa gtgcttgtga acgatgagcc ggacaaccgc 2941 cggggcagaa agctgtatgt tggagatgtg gtagagattg aaggatttgg ttcatttcaa 3001 gtcgtcaatt aaagcgggtg acactgattg tatatccaga acttagaact gacatcttac 3061 cgcaactacg accatgctga acttcaattt gaaaataaag taaatgtgat catcggagaa 3121 aacgcccagg ggaagacaaa cctcatggag gcgatctatg tcttgtccat ggcgaaatcg 3181 caccggacat caaatgacaa agaacttata cggtgggaca aagactatgc taaaatagag 3241 ggaagagtga tgaagcaaaa cggggcgatc ccgatgcagc tcgtcatctc caaaaagggt 3301 aaaaagggca aggtcaatca tattgaacag caaaagctca gccagtatgt cggggccctc 3361 aacaccatta tgttcgcgcc ggaagattta aatcttgtaa agggaagccc tcaagtgaga 3421 aggcggtttc ttgacatgga aatcggacag gtttctcccg tctaccttca tgatctttct 3481 ctttaccaga aaatcctttc ccagcggaat cattttttga aacagctgca aacaagaaaa 3541 caaactgacc ggacgatgct cgatgttctg accgatcagc ttgtagaagt tgcagcaaaa 3601 gtcgtcgtaa aacgcctgca gtttacagca cagctcgaga aatgggcgca gcccatccat 3661 gcaggcatct caagagggct tgaagaactg accctgaaat accatacagc tcttgatgta 3721 tcagatcccc tagatttgtc gaaaatagga gatagctatc aagaagcgtt ttctaaatta 3781 agagaaaaag aaattgagcg tggtgtgacg ctgtcagggc ctcatcgcga tgatgttctt 3841 ttctatgtga acggacgcga tgtgcagacg tatggttctc aaggacagca gcgaacgacg 3901 gcgttgtccc ttaagctggc ggagattgac ctgatccatg aagaaatcgg agaatatccc 3961 attttactat tggatgatgt actgagtgaa ctggatgatt atcgccagtc acacttgctt 4021 catacgatcc aaggccgtgt acaaacgttt gtcacaacga caagcgttga tggcattgat 4081 cacgaaacct tacgtcaagc aggaatgttc cgtgtgcaaa atggtgcgtt agtgaagtga 4141 agaaatgagg tgagcaattg tatattcatt taggtgatga ctttgtggtt tcaacacgag 4201 atattgtcgg catttttgac tttaaagcca acatgtcgcc tattgttgaa gaatttctga 4261 aaaaacagaa acacaaggtg gtgccttccg taaacggcac gcccaaatct atcgtagtca 4321 cggttcagaa tatatattac tctcccttat cttccagcac attaaaaaaa cgtgcgcaat 4381 ttatgtttga aatagattct tagaaatttt ttatcacgaa tatatcgttt agaaaagtgt 4441 aggtgaatga cgtggctatg gaacagcagc aaaacagtta tgatgaaaat cagatacagg 4501 tactagaagg attggaagct gttcgtaaaa gaccggggat gtatatcggt tcgacaaaca 4561 gcaaaggcct tcaccacttg gtatgggaaa ttgtcgacaa tagtattgac gaagccctcg 4621 ccggttattg tacggatatc aatatccaaa tcgaaaaaga caacagtatc acggttgtag 4681 ataatggccg cggtattcca gtcggtattc atgaaaaaat gggccgtcct gcggtagaag 4741 tcattatgac ggtgcttcat gccggaggaa aatttgacgg aagcggctat aaagtatccg 4801 gaggattaca cggtgtaggt gcgtcggtcg taaacgcact atcaacagag cttgatgtga 4861 cggttcaccg tgacggtaaa attcaccgcc aaacctataa acgcggagtt ccggttacag 4921 accttgaaat cattggcgaa acggatcata caggaacgac gacacatttt gtcccggacc 4981 ctgaaatttt ctcagaaaca accgagtatg attacgatct gcttgccaac cgcgtgcgtg 5041 aattagcctt tttaacaaag ggcgtaaaca tcacgattga agataaacgt gaaggacaag 5101 agcgcaaaaa tgaataccat tacgaaggcg gaattaaaag ttatgtagag tatttaaacc 5161 gctctaaaga ggttgtccat gaagagccga tttacattga aggcgaaaag gacggcatta 5221 cggttgaagt ggctttgcaa tacaatgaca gctacacaag caacatttac tcgtttacaa 5281 acaacattaa cacgtacgaa ggcggtaccc atgaagctgg cttcaaaacg ggcctgactc 5341 gtgttatcaa cgattacgcc agaaaaaaag ggcttattaa agaaaatgat ccaaacctaa 5401 gcggagatga cgtaagggaa gggctgacag cgattatttc aatcaaacac cctgatccgc 5461 agtttgaggg ccaaacaaaa acaaagctgg gcaactcaga agcacggacg atcaccgata 5521 cgttattttc tacggcgatg gaaacattta tgctggaaaa tccagatgca gccaaaaaaa 5581 ttgtcgataa aggtttaatg gcggcaagag caagaatggc tgcgaaaaaa gcgcgtgaac 5641 taacacgccg taagagtgct ttggaaattt caaacctgcc cggtaagtta gcggactgct 5701 cttcaaaaga tccgagcatc tccgagttat atatcgtaga gggtgactct gccggaggat 5761 ctgctaaaca aggacgcgac agacatttcc aagccatttt gccgcttaga ggtaaaatcc 5821 taaacgttga aaaggccaga ctggataaaa tcctttctaa caacgaagtt cgctctatga 5881 tcacagcgct cggcacaggt atcggagaag acttcaacct tgagaaagcc cgttaccaca 5941 aagttgtcat tatgacagat gccgatgttg acggcgcgca catcagaaca ctgctgttaa 6001 cgttctttta cagatatatg cgccaaatta tcgaaaatgg ctacgtgtac attgcgcagc 6061 cgccgctcta caaggttcaa caggggaaac gcgttgaata tgcatacaat gacaaggagc 6121 ttgaagagct gttaaaaact cttcctcaaa cgcctaagcc tggactgcag cgttacaaag 6181 gtcttggtga aatgaatgcc acccagctat gggagacaac catggatcct agctccagaa 6241 cacttcttca ggtaactctt gaagatgcaa tggatgcgga tgagactttt gaaatgctta 6301 tgggcgacaa ggtagaaccg cgccgaaact tcatagaagc gaatgcgaga tacgttaaaa 6361 atcttgacat ctaatcataa aaagccttat ttccaataag aaataaggct tttttctgaa 6421 caagatcaga tgcagcgatg cctgcaatac ctatatattc tagcaattta atgtgtataa 6481 tcataagttt attgatataa tggagaatag tgaaatcgta ttgaaggtca taatggacaa 6541 tctactccca catatttcat gtgatacttc agggaggttt tttaatgagt gaacaaaaca 6601 caccacaagt tcgtgaaata aatatcagtc aggaaatgcg tacgtccttc ttggattatg 6661 caatgagcgt tatcgtgtcc cgtgctcttc cggatgttcg tgacggttta aaaccggttc 6721 atagacggat tttgtatgca atgaatgatt taggcatgac aagtgacaag ccttataaaa 6781 aatccgcgcg tatcgttgga gaagttatcg ggaaatacca cccgcacggt gattcagcgg 6841 tatatgaatc catggtcaga atggctcagg atttcaacta ccgttatatg ctcgttgacg 6901 gtcacggaaa cttcggttct gttgacggag actcagcggc ggccatgcgt tatacagaag 6961 cacgaatgtc taaaatctca atggagattc ttcgcgacat cacaaaagac acaatcgatt 7021 accaggataa ctatgacggg tcagaaagag aacctgtcgt tatgccttca aggttcccga 7081 atctgctcgt gaacggtgct gccggcattg cggtaggtat ggcaacaaac attcctccgc 7141 accagctggg agaaatcatt gacggtgtac ttgctgttag tgagaatccg gacattacaa 7201 ttccagagct tatggaagtc attccagggc ctgatttccc gaccgcgggt caaatcttgg 7261 gacgcagcgg tatccggaaa gcatacgaat caggccgagg ctctatcacg atccgggcaa 7321 aagctgagat cgaacaaaca tcttcgggta aagaaagaat tatcgttaca gagttacctt 7381 accaagtaaa taaggcgaaa ttaattgaga aaattgctga tctcgtaagg gacaaaaaga 7441 tagagggtat cacagatctg cgtgatgagt cagatcgtac aggtatgaga attgtcattg 7501 aaatcagacg cgatgccaat gcgaatgtta tcttaaacaa tctgtacaaa caaactgctc 7561 tacaaacatc ttttggcatc aacctgcttg cgcttgttga tggccagccg aaagttttaa 7621 ctcttaagca atgcctggag cattaccttg accatcaaaa agttgtcatt agacgccgta 7681 ctgcttatga attgcgtaaa gcagaagcga gagctcatat cttggaagga ttgagagttg 7741 cactggatca tctcgatgca gttatctccc ttatccgtaa ttctcaaacg gctgaaattg 7801 cgagaacagg tttaattgaa caattctcac tgacagagaa gcaagcacaa gcgatccttg 7861 acatgaggct ccagcgttta acgggactgg aacgtgaaaa gatcgaagaa gaataccagt 7921 ctcttgttaa attaattgca gagctaaaag acatcttggc aaatgaatat aaagtgcttg 7981 agatcattcg tgaagaactc acggaaatca aagagcgttt taacgatgaa agacgtactg 8041 agatcgtcac ttctggactg gagacaattg aagatgaaga tctcatcgag agagaaaata 8101 tcgtagttac tctgacgcac aacggatacg tcaaacgtct tcctgcatca acttaccgca 8161 gtcaaaaacg gggcggaaaa ggtgtacaag gtatgggaac aaacgaagat gatttcgttg 8221 aacatttgat ctctacgtca actcatgaca cgattctctt cttctcgaac aaggggaaag 8281 tgtatcgtgc aaaagggtat gaaatccctg aatacggcag aacggcaaaa ggaatcccga 8341 ttattaacct gctggaggta gaaaagggtg agtggatcaa cgcgattatt ccagtcacgg 8401 aattcaatgc ggagctttac ctcttcttca ctacaaagca tggggtttca aaacgaacat 8461 cgctatctca attcgctaat atccgcaaca atggtctaat tgctctgagt cttcgtgaag 8521 atgatgaact gatgggtgta cgtctgactg acggcacaaa acaaatcatc attggaacga 8581 aaaacggttt actgattcgt ttccctgaaa cagatgtccg agagatggga agaactgcgg 8641 cgggcgtaaa aggcatcacc ctgacggatg acgacgttgt tgtcggcatg gagattttag 8701 aggaagaatc acacgtcctt atcgtaactg aaaaagggta cggaaaacga actcctgctg 8761 aagagtacag aacccaaagc cggggcggaa aaggactcaa aacagcgaaa atcaccgaga 8821 acaacggcca actagtagca gtgaaagcta ctaaaggtga agaggatcta atgattatta 8881 cagctagcgg cgtactcatc agaatggaca tcaatgatat ctccatcacc ggacgtgtca 8941 ctcaaggtgt gcgtctcatc agaatggcag aagaagagca tgttgctaca gtagctttag 9001 ttgagaaaaa cgaagaagat gagaatgaag aagaacaaga agaagtgtga aaaaaagcgc 9061 agctgaaata gctgcgcttt tttgtgtcat aaccctttac agtcataaaa attatggtat 9121 aatcatttct gttgtctttt taaagacaca agcatgacca ttatgactag taaaaacttt 9181 ttcaaaaaag tattgaccta gttaactaaa aatgttacta ttaagtagtc gctttgagag 9241 aagcacacaa agttctttga aaactaaaca agacaaaacg tacctgttaa ttcattttta 9301 taaatcgcac agcgatgtgc gtagtcagtc aaactagggc ctgcacgacg caggtcacac 9361 aggtgtcgcc gcaggatgcg gtgaacttaa cctgtgatcc atttatcgga gagtttgatc 9421 ctggctcagg acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg 9481 agcttgctcc ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa 9541 gactgggata actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt 9601 caaacataaa aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt 9661 tggtgaggta acggctcacc aaggcgacga tgcgtagccg acctgagagg gtgatcggcc 9721 acactgggac tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc 9781 aatggacgaa agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa 9841 gctctgttgt tagggaagaa caagtgccgt tcgaataggg cggtaccttg acggtaccta 9901 accagaaagc cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt 9961 tgtccggaat tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc 10021 ccccggctca accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag 10081 tggaattcca cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg 10141 cgactctctg gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag 10201 ataccctggt agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct 10261 tagtgctgca gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac 10321 tcaaaggaat tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac 10381 gcgaagaacc ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt 10441 cgggggcaga gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt 10501 taagtcccgc aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta 10561 aggtgactgc cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct 10621 tatgacctgg gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg 10681 ttaagccaat cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg 10741 aagctggaat cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt 10801 gtacacaccg cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt 10861 ttaggagcca gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc 10921 gtatcggaag gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc 10981 ttgggtctta taaacagaac gttccctgtc ttgtttagtt ttgaaggaac tttgttcctt 11041 gaataagtta agatgggcct gtagctcagc tggttagagc gcacgcctga taagcgtgag 11101 gtcggtggtt cgagtccact caggcccacc atcttatata acggggcctt agctcagctg 11161 ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg ctccaccaac 11221 gtgttctttg aaaactagat aacagtagac atcacattca attagtaaca caagatatca 11281 catagtgatt ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta 11341 ggagccgatg aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg 11401 atccggagat ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga 11461 attcatagga tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag 11521 agaaagcaaa tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga 11581 ggcttgcctc ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg 11641 aagaggtctg gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc 11701 tcctgagtgg atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc 11761 atctcccaag gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg 11821 tgaaaagcac cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc 11881 agagcccgtt aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatctc 11941 gtgcaaggtt aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg 12001 agtacgtggt cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt 12061 aacactgaat ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta 12121 ggggtgaaat gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct 12181 agcctcaagg taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt 12241 taccgaattc agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt 12301 gataagatcc gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata 12361 cgttaagtgg aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc 12421 caccatttaa agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc 12481 ggggctaaac gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc 12541 taagggctgt gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt 12601 atgagtagcg aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa 12661 ggctcgtccg ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga 12721 caacaggttg atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag 12781 gatagggtaa gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa 12841 atccgtttcc cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga 12901 ttccacactg ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca 12961 caggtaggcg aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca 13021 aaatgacccc gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc 13081 gcagtgaata ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg 13141 cgaagtatag gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa 13201 gcgaaggtgc gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta 13261 gcgaaattcc ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg 13321 tctcaacgag agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag 13381 gacggaaaga ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta 13441 caggataggt aggagccttg gaaaccggag cgccagcttc ggtggaggca tcggtgggat 13501 actaccctgg ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc 13561 aggtgggcag tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt 13621 ccctcagaat ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga 13681 gacctacaag tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa 13741 gggccatcgc tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag 13801 tccacatcga cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag 13861 tcggtcccaa gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg 13921 tcgtgagaca gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct 13981 tagtacgaga ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat 14041 cgctgggtag ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc 14101 tcaagatgag atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat 14161 aggtctgagg tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact 14221 taaccatatt tttgaatgat gtcacacctg ttatctagtt ttgagagaac actctcaatt 14281 tgtttggtgg cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc 14341 tcttcagcgc cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa 14401 gcttaaaccc agctcaatga gctgggtttt ttgtttgtta aaaatgaaga agaaactgtg 14461 aagcgtattt agggaatttc ttttctgata ctaataaaaa ctgctgaatt aacacgtagt 14521 catcacttat atgctgtgtt aataactcat accaccattc tgtttcatac cttgcaatca 14581 tcccaacgtt gtacaaaatc aaataatgaa ttgtcatttc gggaagcctc agaaattgct 14641 ccctttgaga agggatataa tattggttct tttccatgtc aaacaataag ctggtcgatg 14701 tccatggctc cttgtcttgt ggtgaaattt cgaacagcag cccgtgttca tttttttttg 14761 taaaagacca ttgataatga tgggacatgt attcagcaaa ccttgaatca gacattttgt 14821 aattgattac tacttcctcc ggtacaaaaa tttcgttctt atccttctca acttttgtca 14881 taaatcgttc tttctgctga aagtagaaaa tatcgctaag ttctggaatg gccattaata 14941 attttttcat ggtataccgt tcatctacta tatccgattg tccgaataaa tgtttcataa 15001 aatgtacgca taggccattc cgttgtattt tcacttcatc gtcgctaaaa caataatttt 15061 gtttctttcg ttttcttgtt gttacgccat gtgccagtac tgatgtatgg cttggataat 15121 gaggatcacg tgtaattaag catgctttga taagctgtgc cattccataa aataaaagaa 15181 tcggtttgat ttctaaggga gaatatgcgg cttgtttata aaacgattcg gcatgcttta 15241 agaaataaat aaaccgttca ctgtttttaa aagagttttt tttcgcatcg ttaataccgt 15301 ttaagatata aaccttttct agaaatttct gggttgattc aacggagtaa aatagcgcta 15361 agtctttcca ctcatgatat gtcatgtata tttcttaatc ctttccgtta tctaaatatt 15421 tcaactcttt cccgcttcct tgacatgctc ttggctagtt gataatctac atataatatt 15481 ttgccgaaaa gagggggatt tactaatgtg ggaaagtaaa ttttcaaaag aaggcttaac 15541 gttcgacgat gtgctgcttg taccagcaaa gtctgaggta cttccgcgtg atgtggattt 15601 atctgtagaa cttacaaaaa cgttaaagct aaatattcct gtcatcagcg caggtatgga 15661 cactgtaaca gaatcagcaa tggcaattgc aatggcaaga cagggcggct tgggcatcat 15721 tcacaaaaat atgtccattg aacagcaggc tgaacaagtt gataaagtaa agcgttctga 15781 gcgcggcgtt atcacaaatc ccttcttttt aactcctgat caccaagtat ttgatgcgga 15841 gcatttgatg gggaaataca gaatttccgg tgttccgatt gtaaataacg aagaagacca 15901 gaagcttgtt ggaattatta caaaccgtga ccttcgtttt atttctgact actcaatgaa 15961 aatcagcgac gtcatgacga aagaagagct agttactgca tctgtaggaa ctactctgga 16021 tgaagctgaa aagattttgc agaaacataa aattgaaaag cttcctctcg tagatgacca 16081 gaataaatta aaaggtctta tcacaattaa agacattgaa aaagtcattg agttcccgaa 16141 ctcatctaaa gacattcacg gccgcctgat cgttggcgcg gcagttggtg taactggcga 16201 tacaatgact cgcgtcaaaa agcttgttga agccaatgtt gatgtgattg ttatcgatac 16261 agctcacgga cactctcaag gcgttttaaa cacagtcaca aaaatccgtg aaacgtatcc 16321 cgaattaaac attattgctg gaaacgtggc aacagctgaa gcgacaagag cgcttatcga 16381 agctggagca gacgttgtca aagttggaat agggcctggt tcaatttgta ctacacgtgt 16441 tgtagccggc gtgggtgttc cgcaaattac agcaatttat gattgtgcga ctgaagcaag 16501 aaaacacggc aaaacaatca tcgccgacgg tgggattaaa ttctctggcg atatcactaa 16561 agcattggca gccggcggac atgctgttat gctcggaagc ttgcttgcag gcacatcaga 16621 aagccctggt gaaactgaaa tctaccaagg cagaagattt aaggtatacc gcggcatggg 16681 atcagttgct gcaatggaaa aaggaagtaa agaccgttac ttccaagaag aaaacaaaaa 16741 atttgttcct gaaggaattg aaggacgcac accttacaaa gggccagttg aagaaaccgt 16801 ttatcagcta gtcggaggcc ttcgttctgg tatggggtat tgcgggtcca aagatctgcg 16861 tgcgctaaga gaagaagctc agttcattcg catgactggc gcaggacttc gcgaaagcca 16921 tccgcatgac gtacagatta caaaagaatc acctaactat acaatttcat aataaattgt 16981 tacaaattaa aaacatttga cagggtctct gactctgtct atttttttta tactgattat 17041 gataaaattt atactgttgt gcattgaaaa tgtccttaac ggcttaatta tagatgaaga 17101 aaatgaaata cggaggtcgt acgattgaac atcaagaaat gtaaacagct actgatgtca 17161 ttggttgtgt taactctagc tgtcacgtgt ctggctccaa tgtcaaaagc gaaagcagcc 17221 agcgatccaa ttgatatcaa tgcatctgct gctattatga tcgaagcttc ttcaggtaaa 17281 attctttaca gtaaaaatgc agataagaga ctgccaattg cgagtatgac aaaaatgatg 17341 acagagtatc tgttattgga agcaattgat caaggtaaag tgaaatggga ccaaacctat 17401 acgcctgatg actatgtgta tgaaatttcc caagataaca gcttatcaaa cgttcctctt 17461 cggaaagacg ggaaatacac agtaaaagaa ttatatcaag ctacagcaat ttattctgca 17521 aatgctgctg ctattgcgat tgcagaaatc gttgccggtt ctgaaactaa gtttgttgaa 17581 aaaatgaatg caaaagcaaa agaactaggc ttaacagatt acaaatttgt taacgcaaca 17641 ggtcttgaaa acaaagatct tcacgggcat cagcctgagg ggacaagcgt aaatgaagaa 17701 agtgaagttt ctgcaaagga tatggcggtt cttgcggatc acttgattac tgactaccct 17761 gagatactgg agacttccag tatcgccaaa acgaaattca gagaaggcac cgatgatgaa 17821 atggacatgc cgaactggaa ttttatgctg aaggggcttg tcagcgagta taaaaaagcg 17881 actgtagacg gactgaaaac aggttctact gactctgcgg gttcatgctt tacaggaaca 17941 gctgaacgca acggtatgcg tgtcatcact gttgttttaa acgcaaaggg caaccttcat 18001 acaggccgtt tcgatgaaac gaaaaaaatg tttgattatg ctttcgacaa tttctccatg 18061 aaagaaattt atgctgaagg cgatcaagta aaaggccata aaacaatttc agttgataag 18121 ggtaaagaga aagaagtagg cattgtgaca aacaaggcgt tctctcttcc tgtcaaaaat 18181 ggtgaagaaa agaattacaa agcgaaggtc acactgaata aagacaactt aactgctcct 18241 gtgaaaaaag gaaccaaggt tgggaagctg actgcggaat acacaggtga tgaaaaggat 18301 tacggattcc ttaacagcga tctggctggc gtagaccttg ttacaaaaga aaatgtagaa 18361 aaagcaaact ggtttgtttt gacaatgcgc agtatcggcg gattttttgc cggaatttgg 18421 ggaagcattg ttgatacggt aaccggctgg ttttaatcaa ttgaaagagc tctgatggat 18481 gttagggctc tttcgcgtaa tatactgaaa aaacccaatt tttaataaaa aatgattttc 18541 aaagcgctaa aaaccgaata aaatagtata tatgcatatg aattattgga tttctaggat 18601 acaataagga ttagaaatca tataactata ccttgattag ggggaccaag aaatggctca 18661 aacaggtact gaacgtgtaa aacgcggaat ggcagaaatg caaaaaggcg gcgtcatcat 18721 ggacgtcatc aatgcggaac aagcgaaaat cgctgaagaa gctggagctg tcgctgtaat 18781 ggcgctagaa cgtgtgccag cagatattcg cgcggctgga ggagttgccc gtatggctga 18841 ccctacaatc gtggaagaag taatgaatgc agtatctatc ccggtaatgg caaaagcgcg 18901 tatcggacat attgttgaag cgcgtgtgct tgaagctatg ggtgttgact atattgatga 18961 aagtgaagtt ctgacgccgg ctgacgaaga atttcattta aataaaaatg aatacacagt 19021 tccttttgtc tgtggctgcc gtgatcttgg tgaagcaaca cgccgtattg cggaaggtgc 19081 ttctatgctt cgcacaaaag gtgagcctgg aacaggtaat attgttgagg ctgttcgcca 19141 tatgcgtaaa gttaacgctc aagtgcgcaa agtagttgcg atgagtgagg atgagctaat 19201 gacagaagcg aaaaacctag gtgctcctta cgagcttctt cttcaaatta aaaaagacgg 19261 caagcttcct gtcgttaact ttgccgctgg cggcgtagca actccagctg atgctgctct 19321 catgatgcag cttggtgctg acggagtatt tgttggttct ggtattttta aatcagacaa 19381 ccctgctaaa tttgcgaaag caattgtgga agcaacaact cactttactg attacaaatt 19441 aatcgctgag ttgtcaaaag agcttggtac tgcaatgaaa gggattgaaa tctcaaactt 19501 acttccagaa cagcgtatgc aagaacgcgg ctggtaagaa cataggagcg ctgctgacat 19561 gttaacaata ggtgtactag gacttcaagg agcagttaga gagcacatcc atgcgattga 19621 agcatgcggc gcggctggtc ttgtcgtaaa acgtccggag cagctgaacg aagttgacgg 19681 gttgattttg ccgggcggtg agagcacgac gatgcgccgt ttgatcgata cgtatcaatt 19741 catggagccg cttcgtgaat tcgctgctca gggcaaaccg atgtttggaa catgtgccgg 19801 attaattata ttagcaaaag aaattgccgg ttcagataat cctcatttag gtcttctgaa 19861 tgtggttgta gaacgtaatt catttggccg gcaggttgac agctttgaag ctgatttaac 19921 aattaaaggc ttggacgagc cttttactgg ggtattcatc cgtgctccgc atattttaga 19981 agctggtgaa aatgttgaag ttctatcgga gcataatggt cgtattgtag ccgcgaaaca 20041 ggggcaattc cttggctgct cattccatcc ggagctgaca gaagatcacc gagtgacgca 20101 gctgtttgtt gaaatggttg aggaatataa gcaaaaggca cttgtataaa acagttgaaa 20161 gctgtggaaa cttatagtac attataagca caaataaaga tcgaaaagcg ttgataggaa 20221 ctagtaggga gcctctcttt ctaagagagc cgatggttgg tgcgaatcgg tgaaagatgc 20281 tgtctgaatc catccttgag cgaaatgctg aagcgagtag gcatttacgg gataaccgtt 20341 atgtttgaaa gtggaaaacg agtctttgat ttgttttcaa tcagggtggc aacgcgagag 20401 ctctcgtccc tttatgggga tgagggctct ttttattttc gataaatcaa taaaaaaagg 20461 agtgtttcgc atgcttgata cgaaaatgct gagagcaaat tttcaagaaa ttaaagcaaa 20521 gcttgtacac aaaggcgaag acttaactga ttttgataag tttgaggcgc tggatgatag 20581 acgaagagag cttatcggca aggttgaaga gttaaaagga aaacgaaatg aagtttctca 20641 gcaggttgct gtgctgaagc gtgagaaaaa agacgcggat cacattatta aagaaatgcg 20701 tgaagtcggc gaggaaatta aaaagctcga tgaagaatta cggacagtgg aagctgagct 20761 tgatacaatc ctgctctcaa tcccgaatat tccgcatgag tctgtacctg tcggtgaaac 20821 agaagacgac aacgtagaag tgcgtaaatg gggtgaaaag ccttcatttg cttatgagcc 20881 gaagccgcac tgggatattg cggatgagct gggtattctg gattttgaac gtgctgccaa 20941 agtaacagga agccgtttcg tgttctataa aggcttaggt gctcgtctgg agcgtgcgct 21001 ttataacttt atgcttgatc tgcatgtgga tgagtataac tacactgaag tgatcccgcc 21061 atatatggta aaccgcgcaa gcatgacggg aacggggcag cttcctaaat ttgaagagga 21121 tgcatttaaa atcagagaag aagattattt cttaattcca acggcggaag tgccgattac 21181 aaacatgcat cgcgatgaaa tcctttcagg tgacagcctg ccgatcaact atgcggcatt 21241 cagtgcttgc ttccgttctg aagctggttc agcaggacgt gacacacgcg gattaattcg 21301 tcagcaccaa tttaataaag ttgagcttgt aaagtttgtg aagcctgaag attcttatga 21361 agaattagag aaacttacaa accaagcaga acgggttctt cagctgcttg agcttccata 21421 ccgtgtcatg agcatgtgta cgggtgactt aggctttacg gctgcgaaaa aatacgatat 21481 cgaagtttgg attccaagcc aagacacata tcgagaaatc tcttcttgca gcaacttcga 21541 agcgttccag gcgagacgtg cgaatattcg tttcagacgt gaagcgaaag gcaagcctga 21601 gcatgtacac acactgaacg gctcaggact ggcggttgga agaacagttg ctgctatctt 21661 agaaaattat cagcaggaag acggaagcgt tgtgattccg aaagtgcttc gtccttatat 21721 ggggaataga gaagtaatga aaccgtaaat tatggaaagg cgtgcctgac aaggtgcgcc 21781 tttttgctta tgtaaacacg gcattttcat aaaaacaaaa aaagttttta aaaatgcttg 21841 accacacgag aacatacgtg atatagttag tcttgtcgat acggaggaat acccaagtcc 21901 ggctgaaggg atcggtcttg aaaaccgaca ggggtgtcaa agcccgcggg ggttcgaatc 21961 cctcttcctc cgccatattg attttaattc taatgaaaca caagcatata ttggagattg 22021 ttttgtccgt tgcattcggt gcggcggatt ttttatttta aagaaaaagt gaatctcgac 22081 tgagattcac tttttttgat tatcatgaat aactgaagca atttgatcta caatattttc 22141 aatcgagttt tcgtcgttca gaagatcata atcttcaatg cgaagtttta aaacagggca 22201 ggcattaaaa ccgcttatcc agttctcgta gcgtgtatgc atttcttccc aataagaccg 22261 gcttgtctga agctccatct cacggccgcg ttgttcaatc cggtttaaaa tgttctccag 22321 atctccttct aaatagatca acacatctgg atgtgggaaa tacggtgtca ttaccattgc 22381 ttcgaaaagg cttgtgtaag tcttataatc aacctttgac attgtccctt tatcagcatg 22441 catttttgcg aaaattcctg tatcttcata aatcgaacga tcctgtacaa aacctccgcc 22501 ggcttcaaaa attgttttct gttctttgaa gcgttcagct aagaagtaaa tttgaaggtg 22561 aaagctccaa cgttcaaaat catgatagaa cttttccaaa tatggattat gatcgacttc 22621 ctccaacgat gttttaaatc caagccgttt agctaaagtt tttgttaaag tcgattttcc 22681 gacacctact gttcctgcta ctgtaataat tgaattctta gggatatgat gttccttcat 22741 acgataagct cctttacatg ggcggcaatg cgttcaaagt cgctcttatt caaaacgaaa 22801 tcctttgaat caccatctac ggttaacact gtaagttcag ggtctgcttc ctgcagctgc 22861 ttgatggcga cttcataatc tgaaatcagc tgctccaaat agctagtttc aatttttttc 22921 tcaaaggggc gcccgcgttt ttcaatgcgg tgtagcaatg taggcagact ggcctttatg 22981 taaatgatga aattcggctt tggcagatca tccgttagca ggtgatatat ctttttgtat 23041 ttttccagct gatgtggaga caaggttcgt tccgcaaaaa tcacattttt ataaatatga 23101 taatcagcta ttacaggctg tccctttttt aaaaagtgat cactggtgtc ttcaagctgt 23161 ttgtatctgt gacaaagaaa aaacatctcg agctggaagc tccattcctt tatattgtca 23221 taaaacttat caaggtacgg gttatcctct acaatctcat tgatcatagg gaatccgaat 23281 ttttgtgaga gcatcgttgc gagagttgtt tttcctgccc cgataggacc ttctattgca 23341 ataaaagggg ctgtattcat cggaatcctc cttatatctg aaaaacgtgc gtcagttacc 23401 gaccttcata ttgtatcaca acccttgggt gcccccatga aaaaaagacg tttccaaatt 23461 atcgaaacgt ctttttgaca acattaaatt gatcagacag cagcagccag ttttgtggaa 23521 aggaaagacc cagcttccaa tagctgatgc ctcttaaatt cagctcttta atcagattga 23581 attttgcttg aatcgagcgg gcatcctcga accatacctc gtgccttctg ttttctgcat 23641 cagtatagcg gaagaaagga gcttgagcgg tttggtcata ctgaatggaa gcattgttct 23701 gatcagctat gacaatggct tgctgagggc ttactgctct tgctggagtt ccccctgctg 23761 tatatggcag cgtccagtca tatccatata aattctggcc catgacaatt ttgttcgcag 23821 gcatttcagt caaagcatat tctatgacat cacggacagg tccaattgga gaaaccgctt 23881 gaggcggtcc gccgctatag ccccattcat atgtcatgag aacaacaaag tcgacaattt 23941 cgccatgtgc cctgtaatca tgagcttcat accacctgcc ctgctgtgtt gcacttgttt 24001 taggagcaag agccgtagaa atttctaagc cctctcgatg gaaaagatcc cttgcttcgc 24061 ggaggaattg attataggcc tctctatcct ggggccgcaa atattcaaag tcgaaatgaa 24121 tgtcacggaa gccatatctt ctggcattct cgactatttc atttagaagc cgtcttttta 24181 cagtttcgtc gttcaaaagg atccggccaa gttcatcgct gaatgcctgg ttttctaggt 24241 tcgttataat catcatcaat gttgtatttt gactttctgt aatgctcctt aaattcgtta 24301 aaggcggtgc gactaaggtt ccgttccgct gtgcctggaa gctgaatgcg ccaaggtaag 24361 ttaagtaggg cgacgcttct ctggccgcct gctggagatt ttcgctgact tgatttcctc 24421 ggggctccaa ataagcattt gattcgatgt ctcgtttagg agctggaggg atgtataaac 24481 ggaaaccaat ctgaagcacg gtatttaact ggatgcggtt aacccttgcg agctcggctg 24541 ctgttgtatt gaactgccgg gcgatggatg tcagggtatc acctcgcttc acatcataga 24601 actggccagc tattggaatg acaatggttt gtccgacaac aaggctgtcg ggattcggta 24661 tttcattcgt ttcagtgatg tcatttgtgg ttgttctgta ttgtgaagcg atagcagaaa 24721 gagtgtcgcc ttgttttacc acataaattt gaatgaaaaa cgcctccttt catatcgcta 24781 tcaatgtatg aaagaaaagc gctgatcatg tttatttttc tataatttgt tcttccgtcg 24841 taatttctgc gaaaagaaca ttctccatca tggttaaggc gaattcgtta tcttcgtcac 24901 tgtttgacgc gatacagtcc ttaggaatcg tgatgctgta ttccctcata taagcgtcat 24961 tagcggtaaa cagcacgcat atattgccgg ctatacctgt tatgataata tgtctcacct 25021 gcaactcagt aagaagggtg tgaagtgctg tttcgtagaa agcggaatgt ttcggtttga 25081 ttaaaaaata atcagcatct accggagcta tctttgtgat gatatccttg cttctttcat 25141 ttgtgcattc ttgctgtatg tttttaatgt cagcttgcca aagtccataa tgatcattga 25201 tgtaaataat cggccattca ttttgtctcg cgtgctcctt taatgataaa atatgaggaa 25261 cgattttttc tgttttttta gcgagggttt cccccatatc gaattcaaaa ttattgatca 25321 tgtctacaat gagaagggct ttatctgctt tggacaatcg acagtctcct ttccgtttca 25381 gttatagtta atatgtagcc tttttaggca atgaaaaaac tttgaaaaga gagcttatcc 25441 ttatgacaca agatgaactt tatatgaaag aagcaattaa agaagcgaaa aaggctgaag 25501 agaaaggtga agtgccaata ggtgcggtgc ttgtcattaa tggtgaaatt atagcgcgtg 25561 cgcataattt aagagagact gaacagcgat ctattgccca tgcagaaatg cttgtaattg 25621 atgaagcgtg taaggcactc ggaacatggc ggctggaagg tgcgactctt tatgtgacgc 25681 ttgagccttg tccaatgtgt gctggtgcag tcgtactttc tcgagtggaa aaagtggttt 25741 ttggcgcatt tgatccgaaa ggcggctgtt caggcacgct aatgaacctt cttcaggagg 25801 aacgctttaa tcatcaggct gaagtggtga gcggtgtgct tgaggaagaa tgcggcggaa 25861 tgctcagtgc gtttttcaga gaactaagaa aaaagaagaa agccgccagg aaaaacttgt 25921 ctgaatagta cggttgcaat ttttagggga aacagatata cttaagtgtg catcgtaata 25981 gatgcaacat aaaatttgat atttattttg ccgtgctaag cggggaggta gcggtgccct 26041 gtacctgcaa tccgctctag cagggccgaa tcccttctcg aggttcgttt actttaaggc 26101 ctgccttaag taagtggtgt tgacgtttgg gtcctgcgca atgggaattc atgaaccatg 26161 tcaggtccgg aaggaagcag cattaagtga aacctctcat gtgccgcagg gttgcctggg 26221 ccgagctaac tgcttaagta acgcttaggg tagcgaatcg acagaaggtg cacggtaaat 26281 caatcatcaa attttcagac tcacctaata ttaggtgagt tttttgttat gtaaaaagag 26341 cttttggaat cgaaacaagg ttcatgtata atgggaatga tgaataacgg aggagggcaa 26401 acccgtgagt taccaagctt tatatcgagt attcaggcct cagcgctttg aagatgtggt 26461 cggacaagaa cacattacaa aaacgctgca aaatgccctt ttgcaaaaaa agttttctca 26521 cgcctatctg ttttccgggc ctagaggaac cggaaaaacc agtgcagcca aaatatttgc 26581 taaggctgtc aactgtgaac atgctcctgt tgatgagcca tgcaacgaat gtgcggcctg 26641 taaagggata acaaacgggt caatatccga tgtcatagaa attgacgccg cttctaataa 26701 cggtgttgat gagattcgtg acattcgcga taaagtgaag tttgccccat cggccgtcac 26761 atataaggta tatatcatag atgaggtgca tatgctttct atcggcgctt ttaatgcatt 26821 actaaaaaca ttagaagagc cgcctgagca ttgtattttc atattagcaa caactgaacc 26881 gcacaaaatt cctttaacca ttatctctag atgtcagcgt tttgacttta aacgaattac 26941 ctcccaagcg attgtaggcc gcatgaataa aattgttgat gctgaacagc tgcaagtgga 27001 ggaaggatcg ctggaaatca tcgcgagtgc tgcagacgga gggatgaggg atgccctgag 27061 ccttcttgat caggccatat cattcagcgg cgatatcctg aaagtcgaag atgcgctttt 27121 aattacgggt gctgtttctc aattatatat cgggaagctt gcaaaatccc tgcatgataa 27181 aaacgtttct gacgcactgg aaacattaaa tgaattgctt cagcaaggaa aagatccagc 27241 taagctgata gaagatatga ttttctattt cagggacatg ctgctgtaca aaacagcccc 27301 tggcttagag ggagtgcttg agaaagtaaa agtcgatgaa acgttccggg aactaagtga 27361 acaaattccg gctcaggccc tatatgaaat gattgatatt ctgaacaaga gccatcagga 27421 aatgaaatgg acaaatcatc cgcgtatctt tttcgaagtg gccgttgtga agatttgcca 27481 aacctcacat caatctgctg ctgatctccc ggaagtggat atgctgatga aaaaaatcca 27541 gcagctcgaa caggaagtag agcggctcaa aacaacgggc ataaaagcag ctgcggaaag 27601 cccgaaaaaa gaagcgccgc gtgtgccaaa gggcgggaaa tccaattaca aagcgccagt 27661 aggcagaatt catgagattt tgaaggaagc cacaagaccg gatcttgatc tgctcagaaa 27721 cagttggggc aagcttcttg ctcatctcaa acagcaaaac aaagtatcac atgccgcttt 27781 gctgaatgac agtgaacctg tggctgccgg atcggcggca tttgttctga aattcaaata 27841 tgaaattcat tgtaaaatgg tcgctgagga taacaacgga gtccggacta atcttgagca 27901 gattttagaa tcgatgctcg gaaaaagaat ggatttgatt ggcgttccag aagcacaatg 27961 gggtaaaata agagaagaat ttttagaaga tcatcagcag gaaaatgaag gatcaaatga 28021 accggctgaa gaagacccgc ttattgccga agcgaaaaag cttgttggag cggatttaat 28081 tgaaataaaa gactaacaaa atgaaagaga gtgaatgcta tgcgtggcgg aatgggtaat 28141 atgcaaaaaa tgatgaaaca aatgcaaaaa atgcaaaagg acatggcgaa ggctcaagaa 28201 gagcttgcag aaaaggttgt tgaaggaact gcaggcggcg gtatggtaac agtaaaagca 28261 aacggccaaa aagaaatcct ggatgttatc atcaaagaag aagtcgttga tcctgaagat 28321 attgatatgc ttcaagattt agtgcttgct gcaacgaatg aagctttgaa aaaagttgac 28381 gaaatcacaa acgaaacaat gggtcaattt acaaagggaa tgaacatgcc aggtttattc 28441 tagggggata aaagaacatg caatatcctg aaccaatatc aaagctgatt gacagcttta 28501 tgaaattgcc agggatcgga ccgaaaacag cggttcgtct ggcttttttt gttctaggta 28561 tgaaagaaga tgtagtatta gattttgcga aagcattagt aaatgcgaaa cgcaacctga 28621 catattgttc agtttgcggg catattacag atcaggaccc ttgctatata tgtgaagata 28681 cgcgcaggga taagtctgtt atctgtgttg tgcaagaccc taaagacgtt atcgctatgg 28741 agaaaatgaa ggaatacaac ggacagtatc acgttcttca cggcgctatt tctccaatgg 28801 acggcatcgg accggaggat attaaaatac cagaattgtt aaaacgatta caggatgatc 28861 aagtgacaga agtgatcctc gcgacaaacc ctaatataga aggggaagca acagcgatgt 28921 atatatcaag gctcctcaag ccgtctggta ttaagctctc ccgtattgcc cacggactgc 28981 ccgtcggcgg tgatttggaa tatgctgatg aggtcactct ttctaaagca cttgaaggaa 29041 gacgtgaatt gtaaggagga aaaagcgatc catgggtttt cttcgcaaga aaacattaag 29101 aagagagttt gatgaaaaac taaccgagca gctttttaag caaaaggaag agtggaacag 29161 gcaaaaaaag ctggttgaaa aaagcttaga accgtctgct gaagtgttat acgaactgaa 29221 agtagctgaa gcgaagtatt ttttttactt aagggaagcg aagcagcgaa atttaaaaat 29281 cagccggtgg aagtaagtgg tctaaactcc tggatcttct cataagcttg tactagaaca 29341 agcgaaggag atgagaagat tcatggagcc tatttttatt attgggatta ttttaggact 29401 ggttattctt ctttttttat caggttcagc agcgaagcct ttaaagtgga ttggcatcac 29461 agctgttaaa tttgtggcag gtgctttgct gctggtttgt gtaaatatgt ttggcggcag 29521 tcttggcatt catgtgccga ttaatctggt tacaacagct atcagcggaa ttttaggaat 29581 acccggaata gctgcgttag tcgtcattaa gcaatttatc atttaattga tattatgtat 29641 tgacttagac aactgaaggt gttattctaa tatacgtcgc tgatgacgaa cagctttttt 29701 gaaaagaaaa tgctaaaaag ttgttgacag tagcggcggt aaatgttatg ataataaagt 29761 cgcttaaacg agcggtaaac aaagttcttt gaaaactaaa caagacaaaa cgtacctgtt 29821 aattcatttt tataaatcgc acagcaatgt gcgtagtcag tcaaactact ttatcggaga 29881 gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa gtcgagcgga 29941 cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg tgggtaacct 30001 gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt tgtttgaacc 30061 gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc cgcggcgcat 30121 tagctagttg gtgaggtaac ggctcaccaa ggcgacgatg cgtagccgac ctgagagggt 30181 gatcggccac actgggactg agacacggcc cagactccta cgggaggcag cagtagggaa 30241 tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga aggttttcgg 30301 atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg gtaccttgac 30361 ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 30421 gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct taagtctgat 30481 gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt gagtgcagaa 30541 gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag gaacaccagt 30601 ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg gggagcgaac 30661 aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt tagggggttt 30721 ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta cggtcgcaag 30781 actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt ggtttaattc 30841 gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta gagataggac 30901 gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg tgtcgtgaga 30961 tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc attcagttgg 31021 gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg tcaaatcatc 31081 atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag ggcagcgaaa 31141 ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt ctgcaactcg 31201 actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg aatacgttcc 31261 cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga agtcggtgag 31321 gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga agtcgtaaca 31381 aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat tttacggaat 31441 ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt gaaggaactt 31501 tgttccttga ataagttaag atgggcctgt agctcagctg gttagagcgc acgcctgata 31561 agcgtgaggt cggtggttcg agtccactca ggcccaccat cttatataac ggggccttag 31621 ctcagctggg agagcgcctg ctttgcacgc aggaggtcag cggttcgatc ccgctaggct 31681 ccaccaacgt gttctttgaa aactagataa cagtagacat cacattcaat tagtaacaca 31741 agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg gtggatgcct 31801 tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg agctgtaagc 31861 aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg agtggtatcc 31921 atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat ctaagtaccc 31981 ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg gattagccca 32041 aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac aaaggaacga 32101 ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt agtcaaaact 32161 tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg tcggaatccg 32221 ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc agtaccgtga 32281 gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc gtgtgcctac 32341 aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa ccggcgagtt 32401 acgatcccgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga gtctgaatag 32461 ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt ccagggtgaa 32521 gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc ggggatgagg 32581 tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc cgaaatagct 32641 ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac taggggcccc 32701 taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt gggagtcaga 32761 ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag ctaaggtccc 32821 aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga tgttggctta 32881 gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact ctgcgccgaa 32941 aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac agtggtagga 33001 gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt agaagtgaga 33061 atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc ctaaggtttc 33121 ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg aaaggcgtag 33181 gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc aatgggggga 33241 cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt aggctgggaa 33301 ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata tagtagcgaa 33361 gttcctgatt ccacactgcc aagaaaagcc tctagcgagg tgagaggtgc ccgtaccgca 33421 aaccgacaca ggtaggcgag gagagaatcc taaggtgatc gagagaactc tcgttaagga 33481 actcggcaaa atgaccccgt aacttcggga gaaggggtgc tctgttaggg tgcaagcccg 33541 agagagccgc agtgaatagg cccaggcgac tgtttagcaa aaacacaggt ctctgcgaag 33601 ccgtaaggcg aagtataggg gctgacgcct gcccggtgct ggaaggttaa gaggagcgct 33661 tagcgtaagc gaaggtgcga attgaagccc cagtaaacgg cggccgtaac tataacggtc 33721 ctaaggtagc gaaattcctt gtcgggtaag ttccgacccg cacgaaaggc gcaacgatct 33781 gggcactgtc tcaacgagag actcggtgaa attatagtac ctgtgaagat gcaggttacc 33841 cgcgacagga cggaaagacc ccgtggagct ttactgcagc ctgatattga atgttggtac 33901 agcttgtaca ggataggtag gagccttgga aaccggagcg ccagcttcgg tggaggcatc 33961 ggtgggatac taccctggct gtattgacct tctaacccgc cgcccttatc gggcggggag 34021 acagtgtcag gtgggcagtt tgactggggc ggtcgcctcc taaaaggtaa cggaggcgcc 34081 caaaggttcc ctcagaatgg ttggaaatca ttcgcagagt gtaaaggcac aagggagctt 34141 gactgcgaga cctacaagtc gagcagggac gaaagtcggg cttagtgatc cggtggttcc 34201 gcatggaagg gccatcgctc aacggataaa agctaccccg gggataacag gcttatctcc 34261 cccaagagtc cacatcgacg gggaggtttg gcacctcgat gtcggctcat cgcatcctgg 34321 ggctgtagtc agtcccaagg gttgggctgt tcgcccatta aagcggtacg cgagctgggt 34381 tcagaacgtc gtgagacagt tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga 34441 gctgtcctta gtacgagagg accgggatgg acgcaccgct ggtgtaccag ttgttctgcc 34501 aagggcatcg ctgggtagct atgtgcggac gggataagtg ctgaaagcat ctaagcatga 34561 agcccccctc aagatgagat ttcccattcc gcaaggaagt aagatccctg aaagatgatc 34621 aggttgatag gtctgaggtg gaagtgtggc gacacatgga gctgacagat actaatcgat 34681 cgaggactta accacatttt gaatgatgtc acacctgtta tctagttttg agagaacacc 34741 tctctaaagg cggaaggtaa ggaaactccg ctaagggctc tcacatcctg tgagaaacgc 34801 ccagtacctt catcctgaag gcatttgttt ggtggcgata gcgaagaggt cacacccgtt 34861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 34921 gtgagagtag gacgccgcca agcaagctta aacccagctt aatgagctgg gttttttgtt 34981 tactcaagat cgagaaaatc aaacaaatac aaacaccgag ggcttatata gcccatatac 35041 tgatttaaag tttcaaaaag gtctaaatag tgtatacaat atccgtttta aggggaggct 35101 aactgtacgg aggtggagaa gatggacgaa acagttaaac ttaatcatac atgtgtgatt 35161 tgtgatcaag agaagaatag aggcattcat ctttatacga aattcatatg cttagattgt 35221 gagagaaaag taatttctac atcaacttct gatcctgact atgcgtttta cgtaaaaaaa 35281 ctaaagagca ttcatacacc gccattatat tcatagacct gaaaaggtct ttttttgtac 35341 tcttaataat aaaaagaaga tgaaacttgt ttaaggattg aacgtagtag ataataatat 35401 taaaactgag tatagacaca ggagtcgatt atctcatgca gagatttttt cactttttgg 35461 tgtggagttt aactagcagt gcgacttttg ttttcattgg aatattgagc ttttttggtt 35521 taaaccagtc gattttttta tctattgttt atgggcttgc ttctggagca gccgtatata 35581 tagctggcat ctggaatgca agacggttat ttcttaaaaa gcatgaattg acaggaagag 35641 agtatgctta cattaagaaa aacttagagg aagcaaggca gaaaatggtc cgtcttagga 35701 aagccttgtt tcaggctaaa agcattcaaa tgtttaagca aaatgcagaa atgctaagga 35761 ttgtgagaag gatttatctc ctcaccaaaa aagagccaaa gcggttttat caggcagaac 35821 gattttttta tcaaactctc gattcggttg ttgaattgac agagaagtat gcttttctat 35881 catctcaccc aaaaaaaagc aaagaactgt cgatgtcgtt aagtgagaca cgcatcactc 35941 ttactgaatt gaccaagcgt ttagaggaag atttaactca agcaatgggt gatgaaattg 36001 acgagttgca gtttgaatta gacgcagcaa aacattcatt aaagaaataa gggaagaggg 36061 taagagcgat gaaccgagac caaagcgacc ttcatataga tgaattattg gcagatcctt 36121 ttggtggtaa catagagata ccaggttcgg aggctgtaaa agcagagaaa gagcaagtac 36181 ggcttgttga tgttcttcct gaggaaaaca aggaaaaagc aattcagctt gctggacaga 36241 ttgatcataa aaatatgcaa agcattgtct tatacggttc acaagctcaa tctaaactgc 36301 tgaacttttc tcatgatatg attaatcatg ttcaaaagaa ggatgtcggg gagattggcg 36361 aaatacttgg agagctgatg aaaaagctgg agcaagtaaa tcctgatgat ctccaatcta 36421 agaaaaaggg ttttttggca cgcatgtttg gaagagtatc aagttctctt caagaggtgc 36481 tgtctaaata ccaaaagacc agtgtgcaga tagacagaat cagcttgaag ctggagcact 36541 ctaaaaatgc tttaatcagt gacaacaagc tgttagagca gttatatgaa aaaaataaag 36601 aatatttcgc agcgctgaat gtttatattg ctgcaggaga actgaagctg gaggaattaa 36661 aaacaaaaac gattcctgaa ctgaagcaac aggctgaatc gagtgatcat aaccaaatgg 36721 ccgttcaaga ggtgaatgat ttaattcaat ttgctgaccg gttagataaa agggtgcatg 36781 atttgctgct gagcaggcaa attacaatcc aaagtgcacc gcaaatcagg ctgattcaaa 36841 atacaaacca agcgttagct gaaaagattc agtcatccat tgtgacagcg attccgttat 36901 ggaaaaatca agttgccatt gcactgacgc ttttaaggca gcgcaatgca gtggatgcac 36961 agcagaaagt atctgataca accaatgagc ttttgctgaa aaatgcggag cttttaaaaa 37021 ccaatacaat tgaaactgca cgggcaaatg aaagaggcct tgttgatata gataccttga 37081 agaaggtgca ggaaagctta ataagcacgc ttgaagaaac actgactata caagaagaag 37141 gacgaatcaa acgccgtcag gcagaagaag agctcatgat gatggaaggc gacctgaagc 37201 aaaagctgat tacaataaag gaaagatgat taccagtaag tctggcttta agttctgtca 37261 gaggcacgat ataataaggt gtaagaagac acattcaaag gattgttttc atgaacacac 37321 ctttatataa agcattaatt caacatgcga gaagaaattc tcattcattt catgttccgg 37381 gacatcacaa tggagatgtc ttttttgatg acgctaagtc aatattcgat ccgcttctca 37441 ccattgatgt aactgaactg gcaggactgg atgatctcca tcatccttct ggggtgatta 37501 aggaagctca ggagcttgcc agtcaattat atggatcggc ggaaagtttt tttctggtaa 37561 atggtacgac tgtcggaaac ttagcgatga ttttatctgt ttgtgaacct ggtgatacaa 37621 ttctggttca aagaaactgt cataaatctg tatttcatgc tgttgatttg tccggtgctg 37681 agccggttta tcttgcacct gacgttgatt cagcgatgca tgtgcctacg catgttccgc 37741 ttggaacaat taaagaggcc ctggaagcat atccagatgc gaaaggcttg gtactgacca 37801 atccgacata ttacggacat agtgctgatt tgactgagat cattactgaa gcccatcatt 37861 acgggattcc tgttttggtc gatgaagcgc atggcgcaca ttttatttta ggtgagcctt 37921 ttccggtctc agctttaaaa atgggggcag atattgttgt tcagtcggcc cacaaaacgt 37981 tgccagccat gacgatgggt tcttatttgc atctcaacag cagctgcagg attaacaggg 38041 atcgggtggc agagtattta aaccgattac aaagcagcag cccgtcttat ccgattatgg 38101 cttcgttaga tattgcccgc gcttatgtac agcatattat agaagaacaa aagctttctg 38161 acattctgca gcggatagaa acacttaaac aaacgtttga ttcacttaca aatgcagaag 38221 ctgttaaccc tgctaatcca ctgatcatca cggatccgct aaagctcaca attcgttcaa 38281 aacgcgggca ttctggctat acgctgcaaa gcattttaga gcgtgccaac atattcactg 38341 agcttgctga tgaaaatcaa gttctgctcg ttctcccatt gggaggaaaa cggagaataa 38401 acgctgaaat cattagaagc atcgatgaag agattgagaa aacgcctccg gatcagacgt 38461 ttgtttctgc agaatggggt gtgcagcctg ttactgtctt gccttatcca aaaaaggtct 38521 tacattcgtt taagaaagaa tatgtgagct ttgaggaagc agctggccgg cttaatgcag 38581 aagatatcat cccttatcct ccgggtatcc cgatgattat ggcgggagaa agaataacaa 38641 aagaaagtgt gcaaaagctc agccgcttga tcagcatgaa aacgcatgtt caagggaata 38701 tgaaaatcaa agagaaacaa ctacttgttt atatagaaga ggagaaatca tgagcggttt 38761 atttattaca ttcgaaggtc ctgaaggtgc agggaaaacg actgttctgc aggagatcaa 38821 aaacatactg acagcagaag gccttcaggt tatggcaact cgagagccag gcggaataga 38881 tattgcagaa caaattagag aggttattct gaatgagaac aatatattaa tggacccaaa 38941 aacagaagct ctcttatatg cggctgcaag acgccagcat ttagttgaaa aagtaaaacc 39001 tgctttagaa caggggttta tcgttctttg cgacagattc atagacagtt ctcttgcgta 39061 tcaaggatat gcaagagggc ttggaattga tgaggttctg tccattaatg aatttgccat 39121 tggagatatg atgccccatg taacggttta tttttcaatt gatccggaag aaggactgaa 39181 gcgtatttac gcaaacggct cacgggagaa aaacaggctc gatttagaaa aactggactt 39241 tcatacaaaa gtacaagaag gttatcaaga gctgatgaag cgatttccgg aaagatttca 39301 ttcagttgat gccgggcaat ccaaagacct cgtcgttcag gatgttctaa aggtgatcga 39361 tgaagcgttg aaaaaaattc aattgtgacc tgtttcccaa tagttgatat aataatgtaa 39421 acgagatcac gttgtttcca atctaaagga ggccttcaca gatgaaattg atagtggcag 39481 ttgtacaaga tcaggacagc aacagacttt tgaaaacctt aacggatcac aacttcagag 39541 tcacaaagct tgcaacgaca ggaggatttc ttaaatcagg caatacaacg tttatgatcg 39601 gtgtcgagga tatacgcgtc aataaagcgt tgagtctcat taaagaaaac gggcagaaac 39661 gtgatcagat gattgcccct gtatctccaa tgggtggaaa tgctgattcc tatgtccctt 39721 atccagtcga agttgaagtt ggcggagcga cagtatttgt ccttccagtc gatgaatttc 39781 atcaatttta aggatctgaa actgtgaaaa ttaataaaga tatacgtaca tttatagata 39841 ataagcagat tccctctgtg aaaacatctg agatcacagc atcgtttaaa acatcaatgg 39901 aaaaccaaag cagcaaaatg aagcttgatc agcttaccag gctgttatct gatatagaag 39961 catttggaaa aaggctaacg aaatctcgga attttaaaga cttagcgaga tttaaaggac 40021 ttgtgaaacg ttttgtcaaa gaagctgtgg acagcggtct ttcacatgaa acatcgaaaa 40081 gctttgacct ttacgggaac agcagaacgc tgggacttgt gaaagaaata gatgacaaat 40141 tgatacagct tacggaagag atgatggatc aggaaaaacc ggcaattgat ttgctggagc 40201 gtattggcga aataaaaggt ttattaatta acctttacac atagagagtg atacaatggc 40261 aatatcctgg aaggaaatga acgagcttca gcccagagtg atgaagcttt tatataatag 40321 tattgagaag gacagactat cacacgctta tttgtttgag gggaaaaaag gaacaggcaa 40381 gcttgatgcc gcgctgcttc ttgcaaaaag cttcttttgt ctggagggtg gcgcggagcc 40441 ttgtgagagc tgccgaaact gtaaacggat agagtcaggg aaccatcctg atctccatct 40501 tgttcagcct gatggcttat caatcaaaaa ggcgcaaatt caagcgctcc aagaagagtt 40561 ttctaagaca ggacttgaat cgcataaaaa gctgtatatt atttcgcacg cagatcaaat 40621 gacagcaaat gcggcgaaca gcctgctgaa atttttagaa gaaccgaaca aagacacaat 40681 ggccgtcctc atcactgagc agccccaaag gttattggat accatcattt caagatgcca 40741 aacccttcct tttcagcctt tgcagccgaa agcaattgaa gacagactga tcgaacagga 40801 cgtctcgcct catatggcaa ggcttctggc caacatgact aataatgtag cagaagcagt 40861 cgaattaagt cgaaatgatg agtttgcaga gtctagagcg aaagtgataa aattgtatga 40921 agtcctacac cagcggaaag gacatgcttt tttctttatt caagatcaat ggatgccctt 40981 tttcaaagaa aaaacccatc aagaaatggg tcttgatatg ctcttattga tatatcgtga 41041 tgtgttgtcc atccaaatag gaaatgaaga taaattgatt tatcaagact tattccaatc 41101 aataaaacag catgcgctac aatcaacaca acaaagcgtt acgaatcaga tacttgctgt 41161 tttagaagca aagaaacggc ttcattccaa tgtgaatgta caaggattaa tggagcactt 41221 ggtgttaatg ttgcaggagg gataagcttg tacaatgtaa ttggtgtccg ctttaagaaa 41281 gcgggtaaaa tatattattt tgatccgaat ggatttcata tagaacatga cagctgcgta 41341 attgtagaaa ctgtcagagg cgttgagtac ggccaggtcg taattgcaaa taaacaggtg 41401 gatgagcatg atgtggtgct tccccttcga aaagtgatac gtgtggcaga cgatcgcgat 41461 cttctcattg tagaagaaaa taaacaggaa gcactatcag catttgatat ctgccaaaag 41521 aaagtgattg agcatggctt ggatatgaag ctggtcgatg ttgaattcac gtttgatcgc 41581 aataaagtca ttttttactt cactgctgac ggccgagtcg actttagaga gcttgtaaag 41641 gatttggctt ctatctttaa gacaagaatt gagctgcgcc aaatcggagt gagggatgag 41701 gcaaaaatgc tcggaggaat cggtccttgc ggaagaatgc tttgctgttc aacgtttctt 41761 ggagattttg aacccgtttc cattaaaatg gccaaggatc agaacttgtc tttaaatcct 41821 acgaagattt cgggtctttg cggacgattg atgtgctgtc taaaatatga gaacgatgag 41881 tatgagacgg caaaagaaca gcttccggat ataggagaaa tgattacgac agcaaacggt 41941 cccgcgaagg tcgtcggact aaatattctg gaacgggtgc ttcaggtgga actgataaac 42001 cgtgaaaaag tgatagaata tacttgggaa gagctcttgg aagagggcgt cgtatccgca 42061 caaaccacag attaacgagg tgtggaacct tggataaaaa agagttattt gatacagtca 42121 ttaacttaga agaacaaatt ggctcactgt accggcagct gggggatttg aagcagcata 42181 tcggtgagat gattgaggaa aatcatcatt tacagcttga aaacaagcat ttgcgcaaac 42241 ggctggacga tacgacgcag cagattgaaa agttcaaagc tgataaaaaa gaatcaaaaa 42301 cacagaagac agagcaaact gatatagggg aaggatatga taatctggca cgtctgtatc 42361 aagaaggatt tcatatctgc aatgtccact atggaagtgt tcgaaaagag gattgtcttt 42421 tctgtctgtc attcttaaat aaaaaatagg gaaaaggctt ccgcataaga cgggagcctt 42481 tttcaaaggt actgaaagga taagaagatg gtttcattac atgatgatga aagattagat 42541 tatttgctgg cagaggacat gaaaatcata caaagcccaa cagtgtttgc tttttcgttg 42601 gacgctgtgc ttctgtccaa atttgcgtac gttccgattc aaaaagggaa aattgttgat 42661 ttatgcaccg gcaatggtat tgtgccgctg ctgctcagta caagatcaaa agcagacatt 42721 ctgggagtcg aaattcaaga aagactgcat gatatggctg ttcgcagcgt ggagtataat 42781 aagttggacg atcagatcca gatcatacat gatgacctga aaaacatgcc ggagaaactt 42841 ggacataatc gatatgatgt tgtcacctgc aatccgccgt attttaaaac gccgaaacaa 42901 actgaacaaa acatgaacga gcatctccga atcgcaagac atgaaatcca ctgcacgctg 42961 gaggatgtca tttcagtcag cagcaagctg ctcaagcaag ggggaaaagc agctcttgtt 43021 caccggccgg gaaggcttct ggagattttt gaactgatga aggcttatca aatcgagccg 43081 aaacgtgtac aatttgtcta tccgaagcaa gggaaagaag ccaataccat tttggttgaa 43141 ggtatcaaag gcgggcgccc ggatttgaaa attcttcctc ccttattcgt atatgatgaa 43201 caaaatgaat atacaaaaga aatcaggacc attttatatg gagacaaata accatttctt 43261 ctacgtcgtg aaatgtaagg acaatagctg gtatgccggg tataccaacg atctgcataa 43321 acgagtgaaa acgcacaatg atggaaaggg cgcaaagtac acaaaagtaa gacgtccggt 43381 tgaattaatt tttgccgaga gcttttcaac aaagcgggaa gctatgcagg cggaatatta 43441 tttcaaaaaa ctaactcgga agaaaaaaga gctttatata gaagaaaagc ggaacagcaa 43501 ggaggctgta tatgttaagg cgccaaatga gctttaatgg aaagtcggac atggggattc 43561 tttacttggt cccaacccca atcggaaatt tagaggatat gacattccgg gcgatcgaca 43621 cgctgaaatc agtggatgcg attgctgcgg aagatacgag gcaaacgaaa aagctttgtc 43681 atgtatatga aattgaaaca ccgctcgtca gctatcacga acacaataaa gaaagcagtg 43741 ggcacaaaat tattgaatgg ctgaaatcgg gaaaaaacat tgctcttgtc agtgatgccg 43801 gtctgccgac gatttctgat cccggagcgg aaattgtaaa ggattttacg gatataggcg 43861 gttatgttgt tccgttgccg ggagcaaatg ctgcattaac agctcttatt gcttcaggta 43921 ttgtaccgca gccttttttc ttttacggtt ttctcaacag acagaaaaaa gaaaagaaga 43981 aggagcttga agcccttaaa aaacggcagg aaacgatcat tttttatgaa gcgccccaca 44041 gattgaagga aaccttgtca gcgatggcag agatattagg agatcgggaa attgctgtaa 44101 cacgtgaact cactaagaaa tatgaagagt ttatccgagg aaccatatct gaggtcattg 44161 gatgggcaaa cgaggatcag atacgcggcg agttttgtct tgtcgtagaa ggaagtaata 44221 atgaagaggt agatgaggaa gaacaatggt gggaaaccct cactgcgaaa gaacatgtcg 44281 agcattacat ttcgaaaggc gctacgtcta aagaagctat taaaaaagca gcagtcgatc 44341 gcaatgtacc aaagcgtgaa gtgtacgatg cttaccatat taagcaataa aaaaacgttc 44401 ttgtgtcata acaagaacgt tttttgtaca agaaatgatt atttaaggtt ttgaagctgg 44461 ttttggattt cgctgatgat ttgctcagcg ccttctttac taagaaccaa tttaccgcct 44521 gcaagtttaa ggttatcatc agaaacttca ccagttactt ggcaagtcat gtttggttta 44581 tattttttaa ggatgatttt ttcatcatca acatagattt caagagcatc tttttctgcg 44641 attccaagag tacgacgcag ttcgatagga ataactacac gtcctaattc atcaacttta 44701 cgtacaatac cagtagattt cataaacatt ctcctcccaa gagatactta tttgtttaaa 44761 ttatattttt cttcgtcatt attcgacaaa atccttacct tcatagcata acaaggtttc 44821 caataatcgt caatcatttt gtttactatt gattgtaaga attagttctt atagtcagta 44881 atgtcttgga aactaccgaa ataacagcat tttataaata tttaataaag ctattatcct 44941 actaaaaatc cttttaaatc aagactttcg aaccaaagtt ttttatttca tttgattata 45001 tacgacaaaa ttcgacacga acagactttt tttattttca ttaaagattt ttaattttaa 45061 ttattctttt tcagggcgta tgtatatatt cttgatctta aaggctaaga tggtatcata 45121 gataaaggat aaatataaat aatattcata tatgatttgc acttatcgcc gctctcgtcc 45181 tttgggcggg agctttttga cattctgatt aggaggtttc aagatgccgc aagaaaacaa 45241 tacattttac attacaacac cgatttatta tccgagcgga aaattacata tcggccatgc 45301 atatacgaca gtcgcaggag atgcaatggc acgttacaaa agattaaaag ggttcgatgt 45361 tcgctattta acgggaacgg acgagcatgg acaaaagatc cagcaaaaag ctgaacagga 45421 aaacattaca cctcaggagt atgtggatcg cgcagcggca gatattcaaa aactgtggaa 45481 gcagcttgaa atctcaaacg acgactttat ccgcacgaca gaaaaacggc ataaagttgt 45541 cattgaaaaa gtgtttcaaa agcttcttga taacggggac atctatcttg atgagtatga 45601 aggctggtac agcatccctg atgaaacgtt ctacacggaa actcagctcg ttgatattga 45661 gcggaatgaa aagggagagg tcatcggcgg aaaaagccct gacagcggtc acccagttga 45721 attgatcaaa gaggaatctt atttcttccg catggggaaa tacgcggatc gtcttctgaa 45781 atactatgaa gaaaacccga cattcattca gccagaatca cgcaaaaacg aaatgattaa 45841 taactttatc aaacctggac ttgaggattt ggcagtatca cgtaccactt ttgattgggg 45901 cgtgaaggtg ccggaaaatc caaagcatgt tgtatatgtt tggattgacg cactatttaa 45961 ctatttaacg gcactcggtt atgatacaga aaatgatgag ctttatcaaa aatattggcc 46021 tgccgatgtt catttagtcg gtaaggagat tgtacgattc catactattt actggccaat 46081 tatgctgatg gcgctggatc ttccgctgcc aaagcaagta ttcgcgcatg gctggctttt 46141 gatgaaagac ggaaaaatgt cgaaatcaaa aggaaacgtt gtagatccgg ttacattaat 46201 tgaacgctat ggtttagacg aacttcgcta ttacttgctt cgcgaagtgc cgttcggatc 46261 agacggtgtt ttcacgccgg aaggatttgt tgagcgaatc aactatgatt tagcgaatga 46321 tttaggaaat ctattgaatc gtactgttgc gatgattaat aagtattttg acggacaaat 46381 cggttcttac aaaggtgctg ttacggaatt tgaccatacg ctcacttctg ttgctgaaga 46441 aacagtgaaa gcttatgaga aagcaatgga aaatatggag ttctcggtag cactttcgac 46501 tttatggcag ctcatcagcc gcacaaacaa atacattgat gagacagctc catgggtgct 46561 tgcgaaagat ccggcaaaag aagaagaatt gcgatcagtt atgtatcatc tcgctgaatc 46621 attgcgtatt tcagcggtac tgcttcagcc attcttaaca aaaacacctg aaaaaatgtt 46681 cgagcagctg ggcattactg atgaatcttt aaaagcttgg gacagcatta cagctttcgg 46741 ccagctgaaa gatacaaaag tacaaaaagg cgagccattg ttccctcgtt tagaggcaga 46801 agaagaaatt gcttacatca aagggaaaat gcaaggttca gcaccagcga aagaagaaac 46861 aaaagaagaa gagcctcaag aggtcgatcg tttacctgaa attacgattg atcaatttat 46921 ggatgtagag cttcgcgtag ctgaggtcat tgaggcagag ccagtgaaaa aagcagaccg 46981 tttattgaag ctgcagcttg atcttggttt tgaaaagcgc caagtggtat ccggcattgc 47041 gaagcattat acgcctgaag agcttgttgg aaaaaaactc gtttgtgtaa caaatctaaa 47101 accggttaaa ctcagaggag agctttctca aggtatgatc cttgcaggag aagcagacgg 47161 cgttttaaag gtcgtatcta tcgatcagtc gttaccaaaa ggcacaagaa ttaaataatg 47221 ataaacaaaa ggtgtttcac gtgtaacaat tcgtcgaaca ccttttgtgt ttcgacaaga 47281 aaggagtttt tcacttatgt tgtttgacac tcacgcgcat ttaaatgcag aacaatatga 47341 tactgatctt gaagaggtta ttgaacgggc aaaagctgaa aaagttgaac gaattgtcgt 47401 agttggtttt gaccgtccga cgattacccg tgcgatggaa atgattgagg aatatgattt 47461 tatttatgca gccattggct ggcaccctgt tgacgctatt gacatgacag aggaagactt 47521 agcgtggatt aaagagcttt ctgctcatga gaaagtggta gcgatagggg aaatgggact 47581 ggattatcat tgggataaat cacctaaaga tattcaaaaa gaggtgttta gaaatcaaat 47641 cgccttagcg aaagaggtca atttgcctat tatcattcat aaccgtgatg caacggagga 47701 tgtcgtgacc attttgaaag aggaaggcgc agaagctgtg ggcggaatca tgcactgctt 47761 tacaggaagt gcggaagtgg caagagaatg catgaaaatg aatttttatt tatcatttgg 47821 gggaccggtg acatttaaaa atgcgaagaa accgaaggaa gtagtgaagg aaattcccaa 47881 tgaccggctg ctgattgaaa cggactgccc gtttctcaca ccgcaccctt tccgcgggaa 47941 aagaaatgag ccaagctatg tgaaatatgt ggcagaacaa atcgccgaat taaaagaaat 48001 gacctttgaa gagattgctt ccatcacgac tgaaaatgcg aaaagacttt tccgtataaa 48061 ctgacaaaaa acgctagcgg gttttgtaag agcttgtccc ttacagcgtt tttctataaa 48121 agttctacat gctttcttct cctcatagga taggtttgtc gacaagtctt tcttccgttt 48181 ctcagtgtat ttcaggataa tgaagaggac actgagcttt tgggagaaag agaagggagg 48241 gttgacagcc ttttagatac tctatataat ctctccgagg agaaggaggc gtttttcatc 48301 acacaaaaaa tgaaaaagct gttttccgta aagcttagca aaagcaaagt cattctggtt 48361 gctgcttgtt tgcttttggc aggaagcggg actgcgtacg cggctcatga gctgacgaaa 48421 caatcagtct cagtttctat caatggcaaa aagaaacata tacgcacaca tgcaaataca 48481 gtcggtgatc ttttggagac gcttgatata aagacaagag acgaagacaa gatcacacct 48541 gctaaacaga caaagataac agcagacatg gacgttgtgt atgaggctgc aaaacctgtg 48601 aagcttacaa taaacgggga agaaaagacg ttatggtcaa cagcaaaaac ggtcggtgca 48661 ttactggacg aacaagatgt tgatgtgaaa gaacaagatc aaattgatcc cgcaatagat 48721 acagatattt cgaaagacat gaagattaac atagagcccg catttcaggt tactgtgaat 48781 gatgcaggga aacaaaagaa gatctggacg acttcgacta cggtcgctga ctttttaaaa 48841 cagcaaaaga tgaacataaa agacgaagat aaaatcaagc ctgcgttaga tgcaaagctg 48901 acgaaaggaa aggctgatat tacaattact cgtatcgaaa aggtcaccga tgtagttgaa 48961 gagaagattg cgttcgatgt gaaaaagcaa gaagacgctt ctcttgaaaa agggaaagaa 49021 aaggtcgtcc aaaaaggaaa agaaggcaag ctaaaaaaac atttcgaagt cgttaaagaa 49081 aacggtaaag aagtgtccag agagcttgta aaagaagaaa cagctgaaca aagcaaagat 49141 aaagtgattg ctgtcggcac aaagcaaagc agtccaaaat ttgaaacggt cagtgcttca 49201 ggtgattcaa aaacagttgt gtcccgcagc aatgaatcaa caggcaaagt catgactgta 49261 tcatctacgg cttatacggc aagctgcagc ggttgttcag gacatacagc gacaggcgtc 49321 aatttaaaaa ataatccgaa tgccaaagtc atcgctgtgg atccaaatgt cattccgcta 49381 ggctccaaag tccacgtgga aggctatgga tatgccattg ctgcagatac cggttcagcg 49441 attaaaggga acaagataga cgtctttttc ccagagaaat catcggcgta ccgatgggga 49501 aataaaacag tcaaaattaa aatcttaaat tagtatatac ttatgtattc agagggtttt 49561 gcgccctctg tttttttcgt tataatagac aaagtgcatt ttctgcttat tagacgctcg 49621 atataagaaa aagtttcatg aatatacaaa agtttttatt ttgtcttgga ggaaataatg 49681 aaaattaaag agatcattgt ggtcgagggg cgtgacgata cggcccgcat caaattggct 49741 gttgatgcag acacaattga aacaaatggt tcagccatcg atgatcatgt gattgaccaa 49801 atccgtttgg cccagaagac gagaggcgtc attattttaa cggatccgga ctttccggga 49861 gagaagattc gcaaaaccat ctcagaggct gtacccggct gtaagcatgc atttttgcca 49921 aaacatcttg ccaaacctaa aaacaagcgg ggaattggtg tggagcatgc atcggttgaa 49981 agcattaggg catgtttaga aaatgtgcat gaggagatgg aagcgcagcc gagtgacatt 50041 tcagctgagg atttgattca tgccggacta ataggcgggc ctgcggccaa atgccgccgg 50101 gaacgactgg gtgatctgtt gaaaatcggc tatacaaatg gcaaacagct tcaaaaacgg 50161 ctgcaaatgt ttcaaattaa aaaaagtgat tttatgagtg cgctcgatac cgttatgcgg 50221 gaggaacaga atgaataaag atattgcgac accgattaga acgaaagaga tactgaagaa 50281 atacggtttt tcttttaaaa agagcttagg acagaatttc ttaattgata cgaacatttt 50341 aaacagaatt gttgatcacg cggaagtgac ggagaaaaca ggtgtcattg aaatcggccc 50401 gggaatcggg gctttaaccg aacagcttgc caagcgggcg aaaaaggtcg tggcatttga 50461 gattgaccag cgattattgc cgattctgaa ggatacactg tcaccttacg aaaatgtcac 50521 tgtcattcat caggacgtgt taaaggctga tgtcaaatca gtcattgaag aacaatttca 50581 agattgtgat gagatcatgg tagttgccaa ccttccttat tacgtaacaa caccgattat 50641 catgaaactg cttgaagaac atcttccgct gaaagggatt gtggttatgc tgcaaaaaga 50701 agtggctgag cgcatggcgg ctgatccttc atctaaggaa tacggctcgc tttcaatcgc 50761 ggtgcagttt tatacagaag ccaaaacggt gatgatcgtc ccgaaaaccg tatttgttcc 50821 tcagcctaat gtcgattccg cagtcattcg tctgattctc cgagacggcc cggcagtgga 50881 cgtggaaaac gaatcctttt tctttcagct catcaaggca agctttgcac agcgccgtaa 50941 aacgctgctc aataacttag ttaacaatct gcctgaagga aaagcacaaa aatcaacgat 51001 tgaacaagtg ctcgaagaaa caaatattga cggtaagcgc cgaggtgaat ccctgtctat 51061 tgaggaattc gcagcgctgt ctaacggatt gtataaagcc cttttctaaa agggcttttt 51121 gttttgcgca ccacatggac tgccgctaca taggctagag aaggaccttt cattcaatga 51181 taagaaaaaa cttggactca gcgaaaaaag gcgctttctc aaggctcttt ctttcatgat 51241 gaggcttagt ctatgtgtgg agtgaggaac gtgcaatttc aaatagggga tatggtagcc 51301 agaaaatcct atcagatgga tgttttgttt cgaattatag gaatagagca aacaagcaaa 51361 ggaaattcaa ttgccatttt gcatggagat gaagtcaggc tgattgctga ttcggatttt 51421 tctgatctgg tggcagtgaa aaaggatgag cagatgatgc ggaaaaagaa agatgagagc 51481 agaatgaatg agtcgctcga attgctccgc caagattata agctgctcag agaaaagcag 51541 gagtactatg cgacaagcca atatcagcat caggagcatt atttccatat gccgggcaaa 51601 gtgcttcatc tggatggtga cgaagcatat ttgaaaaaat gcctgaatgt ctataaaaaa 51661 attggagtgc cggtctatgg catccattgc catgaaaaga aaatgtctgc ttctattgaa 51721 gtattgctcg acaaatatcg acctgacatc ctggtgatca cagggcatga tgcgtactcg 51781 aagcaaaagg gcggtattga tgatttgaat gcgtacagac attctaagca ctttgttgaa 51841 acagttcaaa cagcccgaaa aaagatccct cacttagatc agcttgttat ttttgcgggg 51901 gcctgccaat cccattttga atcactcatc agagcgggtg cgaattttgc aagttcaccg 51961 tcaagagtca atattcatgc gcttgatccg gtatatatcg tcgcgaagat cagctttacg 52021 ccgtttatgg aacggattaa tgtatgggaa gtgctccgta atacgctgac aagagagaaa 52081 gggcttggag gtattgaaac aagaggagtt ctgagaattg gtatgcctta taagtccaat 52141 taacagttga aaacctgcat aggagagcta tgcgggtttt ttattttaca taatgataca 52201 taatttaccg aaacttgcgg aacataattg aggaatcata gaattttgtc aaaataattt 52261 tattgacaac gtcttattaa cgttgatata atttaaattt tatttgacaa aaatgggctc 52321 gtgttgtaca ataaatgtag tgaggtggat gcaatggcga agacgttgtc cgatattaaa 52381 agatcgcttg atgggaattt aggtaaaagg ctgacgttaa aagcaaacgg tggccgccga 52441 aaaacgattg agcgttcggg cattttagct gagacgtacc cttctgtttt tgtgatacaa 52501 ctagatcaag acgagaactc gtttgaaaga gtttcataca gttatgctga tattttgact 52561 gagactgttg agctgacatt taatgatgac gccgcaagct cagtggcatt ttaacgggca 52621 gtgaaccttt tgtttactgc tttttgtttt gccctttttt ggtttccaat aattttaacg 52681 aaagttccat ctgatttaac aaaagataaa acagtcacat attatcgtga cgtgcacgaa 52741 tggctatcac ttctaaaaaa ggagttgttt cgtttgggca gacgtcgtgg agttatgtca 52801 gatgagttta aatatgagct ggctaaagac cttggttttt atgacacagt aaaaaatgga 52861 ggctggggtg aaattcgggc ccgcgatgcc ggtaacatgg tgaagcgtgc tattgaaatc 52921 gccgaacagc aaatggctca gaatcagaat aaccgataag gatgtgaccc gggggacgtg 52981 ctgttccctg gtttttttat tttggatata aatacataat gggctgaata tggatatgtt 53041 catcctgtac ttcaaatgtg atacaatgtt catacttatg tttagatgga gaagtaggtg 53101 aaagctatgc gtattttaga aaaagcgcca gctaagatca atctgtcact tgacgtcacc 53161 cgaaaacgcc cggatggcta tcatgaagtc gaaatgatca tgacgacaat tgatttagct 53221 gatcgaattg aattgacgga gcttgcagag gatgaagtga gggtttcctc ccacaaccga 53281 tttgtgcctg atgaccaaag aaacttagct tatcaggctg ccaagctgat caaggacaga 53341 tacaacgtga aaaagggagt ttccatcatg attacgaagg taattccggt ggctgccggt 53401 cttgccggcg gaagcagtga tgcggcggcg acactcagag ggctgaacag actgtggaat 53461 ttaaatctgt ccgcggaaac gcttgctgag cttggagcgg aaattggctc tgacgtttca 53521 ttttgtgtct atggcggaac tgcattagca acagggcgcg gcgagaaaat taaacatatc 53581 agcacgcctc cgcactgctg ggtcatttta gcgaagccga caatcggtgt ttcaactgct 53641 gaagtgtaca gagcgctgaa actggatggt atagagcatc ccgatgtaca aggcatgatc 53701 gaggcgatag aagaaaagag ttttcagaag atgtgcagcc ggttaggcaa tgtgcttgaa 53761 tctgttacac tcgatatgca tcctgaagtt gcgatgatca aaaaccagat gaaacgcttt 53821 ggtgcagatg ccgtgttaat gagcgggagc ggcccgacag tgtttggact ggttcagtat 53881 gagtcgaagg tgcagagaat ttataacggg ttaagaggct tctgcgatca agtttatgcg 53941 gtgagaatga tcggcgaaca gaacgctctt gattaaatcc gtatgttaag ttatattgat 54001 cttaaaatat tcggattttg ggggtgagtt catgaagttt cgtcgcagcg gcagattggt 54061 ggacttaaca aattatttgt taacccatcc gcacgagtta ataccgctaa cctttttctc 54121 tgagcggtat gaatctgcaa aatcatcgat cagtgaagat ttaacaatta ttaaacaaac 54181 ctttgaacag caggggattg gtactttgct tactgttccc ggagctgccg gaggcgttaa 54241 atatattccg aaaatgaagc aggctgaagc tgaagagttt gtgcagacac ttggacagtc 54301 gctggcaaat cctgagcgta tccttccggg cggttatgta tatttaacgg atatcttagg 54361 aaagccatct gtactctcca aggtagggaa gctgtttgct tccgtgtttg cagagcgcga 54421 aattgatgtt gtcatgaccg ttgccacgaa aggcatccct cttgcgtacg cagctgcaag 54481 ctatttgaat gtgcctgttg tgatcgttcg taaagacaat aaggtaacag agggctccac 54541 agtcagcatt aattacgttt caggctcctc aaaccgcatt caaacaatgt cacttgcgaa 54601 aagaagcatg aaaacgggtt caaacgtact cattattgat gactttatga aagcaggcgg 54661 caccattaat ggtatgatta acctgttgga tgagtttaac gcaaatgtgg cgggaatcgg 54721 cgtcttagtt gaagccgaag gagtagatga acgtcttgtt gacgaatata tgtcacttct 54781 tactctttca accatcaaca tgaaagagaa gtccattgaa attcagaatg gcaattttct 54841 gcgttttttt aaagacaatc ttttaaagaa tggagagaca gaatcatgac aaaagcagtc 54901 cacacaaaac atgccccagc ggcaatcggg ccttattcac aagggattat cgtcaacaat 54961 atgttttaca gctcaggcca aatccctttg actccttcag gcgaaatggt gaatggcgat 55021 attaaggagc agactcatca agtattcagc aatttaaagg cggttctgga agaagcgggt 55081 gcttcttttg aaacagttgt aaaagcaact gtatttatcg cggatatgga acagtttgcg 55141 gaagtaaacg aagtgtacgg acaatatttt gacactcaca aaccggcgag atcttgtgtt 55201 gaagtcgcga gactcccgaa ggatgcgtta gtcgagatcg aagttattgc actggtgaaa 55261 taataagaaa agtgattctg ggagagccgg gatcactttt ttatttacct tatgcccgaa 55321 atgaaagctt tatgacctaa ttgtgtaact atatcctatt ttttcaaaaa atattttaaa 55381 aacgagcagg atttcagaaa aaatcgtgga attgatacac taatgctttt atatagggaa 55441 aaggtggtga actactgtgg aagttactga cgtaagatta cgccgcgtga ataccgatgg 55501 tcgcatgaga gcgattgcat ccatcacgct ggatcacgaa tttgttgtac atgatattcg 55561 tgtgattgat ggaaacaatg gtcttttcgt tgcgatgccg agtaaacgca cccctgatgg 55621 agagttccgc gatattactc atcctattaa ttcaagcacg cgaggaaaga ttcaagatgc 55681 cgtgttaaat gagtatcatc gtctgggtga cactgaagca ttagaattcg aagaagctgg 55741 agcttcttaa aaaataacca aaaagcaagg actgctgaaa gggctgacat aagccttttg 55801 ccggcggtcc ttttttaatt ctgatttttc aaacttagtt gcactcaata gaaaattctt 55861 gcacttcatg aagtctcctt gaaatcagaa gatatttagg atatattttt ctatggataa 55921 aagggatatt ggaggccaat aaatggataa gcggtttgca gttgttttag cggctggaca 55981 aggaacgaga atgaaatcga agctttataa agtccttcat ccagtttgcg gtaagcctat 56041 ggtagagcac gtcgtggacg aagccttaaa attatcttta tcaaagcttg tcacgattgt 56101 cggacatggt gcggaagaag tgaaaaagca gcttggtgat aaaagcgagt acgcgcttca 56161 agcaaaacag cttggcactg ctcatgctgt aaaacaggca cagccatttc ttgctgacga 56221 aaaaggcgtc acaattgtca tttgcggaga tacgccgctt ttgacagcag agacgatgga 56281 acagatgctg aaagaacata cacaaagaga agcgaaagct acgattttaa ctgcggttgc 56341 agaagatcca actggatacg gccgcattat tcgcagcgaa aacggagcgg ttcaaaaaat 56401 agttgagcat aaggacgcct ctgaagaaga acgtcttgta actgagatca acaccggtac 56461 gtattgtttt gacaatgaag cgctatttcg ggctattgat caggtgtcta atgataatgc 56521 acaaggcgag tattatttgc cggatgtcat agagattctt aaaaatgaag gcgaaactgt 56581 tgccgcttac cagactggta atttccaaga aacgctcgga gttaatgata gagttgctct 56641 ttctcaggca gaacaattta tgaaagagcg cattaataaa cggcatatgc aaaatggcgt 56701 gacgttgatt gacccgatga atacgtatat ttctcctgac gctgttatcg gaagcgatac 56761 tgtgatttac cctggaactg tgattaaagg tgaggtgcaa atcggagaag atacgattat 56821 tggccctcat acggagatta tgaatagtgc cattggcagc cgtacggtta ttaaacaatc 56881 ggtagtcaat cacagtaaag tggggaatga tgtaaacata ggaccttttg ctcacatcag 56941 acctgattct gtcatcggga atgaagtgaa gatcgggaat tttgtagaaa ttaaaaagac 57001 tcaattcgga gaccgaagca aggcatctca tctaagctat gtcggcgatg ctgaggtagg 57061 cactgatgta aacctgggct gcggttcaat tactgtcaat tatgatggaa agaataagta 57121 tttgacaaaa attgaagatg gcgcgtttat cggctgcaat tccaacttgg ttgcccctgt 57181 cacagtcgga gaaggcgctt atgtggcggc aggttcaact gttacggaag atgtacctgg 57241 aaaagcactt gctattgcca gagcgagaca agtaaataaa gacgattatg tgaaaaatat 57301 tcataaaaaa taatcctaaa ttcggaggtt tatccatgtc taatcaatac ggagataaga 57361 atttaaagat tttttctttg aattcgaatc cagagcttgc aaaagaaatc gcagatatag 57421 ttggagttca attagggaaa tgttctgtca caagatttag tgacggggaa gtccaaatta 57481 atatcgaaga aagtattcgc ggatgtgatt gttacatcat ccagtctaca agtgaccccg 57541 ttaacgagca tattatggaa ctgctgatta tggtagatgc gttaaaacgc gcttctgcaa 57601 aaacgattaa cattgttatt ccttattacg gttatgcgcg tcaagacaga aaagcaagat 57661 cccgtgagcc aatcacagct aaacttttcg ctaacctgct tgaaacagcc ggtgcgactc 57721 gtgtgattgc acttgacctg catgcgccgc aaattcaagg attctttgat ataccgattg 57781 accacttaat gggtgttccg attttaggag aatattttga aggcaaaaat cttgaagata 57841 tcgtcattgt ttcaccagac catggcggtg tgacacgtgc ccgcaaactg gctgaccgac 57901 taaaagcgcc aattgcgatt atcgataaac gccgtccgcg tccaaacgtg gcggaagtca 57961 tgaatattgt aggtaacatc gaagggaaga ctgctatcct catcgatgac attattgata 58021 ctgcaggtac gattacactt gctgctaatg cgctcgttga aaacggagcg aaagaagtat 58081 atgcatgctg tacacaccct gtactatcag gccctgcggt tgaacggatt aataattcaa 58141 caattaaaga gcttgttgtg acaaacagca tcaagcttcc tgaagaaaag aaaattgaac 58201 gctttaagca gctttcagtc ggaccgcttc tggccgaagc gattattcgc gttcatgagc 58261 agcaatcagt cagctatctg ttcagctaaa ccatttttcg aggtttaaat ccttatcgtt 58321 atgggtattg tttgtaatag gacaactaaa acgacaagag gatggtgctg aatatggcaa 58381 ctttaacggc aaaagaaaga acggacttta ctcgttcgtc tcttcggaat atccgtactt 58441 caggacatgt tccaggtatc atatatggga aggatacggg taacaaacct gtgtcattag 58501 acagtgtgga gctcatcaaa acgctgaggg acgaaggcaa aaatgcagtc attacgcttg 58561 aggtcagcgg agaaaaacac tcagtcatgg taacagacct gcagacggac ccgctgaaaa 58621 atgaaatcac tcatgctgat tttcaagtag ttaatatgag tgaggacatt gaagtggaag 58681 ttccgattca tctgaccgga gaagccattg gagtgaaaaa cggaggcgta ctgcagcagc 58741 cgttatatgc acttactgta aaggccaagc caaaagccat tccgcaaacg attgaggctg 58801 atatttcaag cctcgatgta aatgaagtac tgacgattgc ggatttgcct gctggcggtg 58861 actactcctt taatcatgaa tcagatgagg ttgtggcttc aatccttcct ccgcagcagc 58921 aggaagcagc tgaggtcgat gaagaggaat ctgccgatgc tcagcctgaa ggtgaaaacg 58981 aacaataata gcttaaggcg taaccctccc gcggttacgt cttttgtgct agaatgagaa 59041 gaattatagc ccgtttatga agacgggagt tatgtgacta agggaggatt cgccatgctt 59101 gtgattgccg gtctcggaaa cccggggaag aactatgaaa atacacggca taatgtcgga 59161 tttatggtga tagatcagct tgcaaaggaa tggaatatag agctgaatca aaataaattt 59221 aacggattat acggaaccgg atttgtttcc ggcaaaaagg ttctacttgt taaaccgctt 59281 acatatatga atttatcagg agaatgtttg cggcctttaa tggactacta tgatgtcgat 59341 aacgaagatt tgacagtcat ttacgacgac cttgaccttc cgactggcaa gatccgttta 59401 agaacgaaag gaagcgccgg agggcacaat ggcatcaaat cactgatcca gcatcttgga 59461 acgtccgagt ttgaccgtat ccgcatcgga atcggccggc ctgtaaacgg catgaaggtc 59521 gttgattatg tgttaggctc ctttaccaag gaggaggcac ctgagatcga agaagcggtt 59581 gataaatctg tgaaggcttg tgaggcttct ttgagtaaac cgtttttaga agtcatgaac 59641 gaatttaacg caaaggtata aaatgtaaca acaaagtcca tactacacca aaatgacttt 59701 ttcatcagga ggacccttgt atggctttgc attattattg tcgtcattgc ggagtgaaag 59761 taggcagtct cgaatcttca atggtatcga cagactcact tggatttcag cacttaacaa 59821 atgaggaaag aaacgatatg atttcttata aagaaaatgg agatgtccat gttttgacga 59881 tatgtgaaga ctgccaagag gcgcttgacc gaaatccgca ttaccacgaa tatcacacat 59941 ttattcaata aaaagctttg gtgtagacac tagaccaaag cgtttttctg ttctcgcagg 60001 aaacagagag gaggggccat atggacaaca ttcaaacctt tataaaagaa agcgatgact 60061 ttaaatccat catcaacggt ttacacgagg gcctgaagga acagctgctc gcgggtctgt 60121 cgggttccgc gcgttctgtt tttacttctg ctctggctaa tgaaacgaat aagcctatct 60181 ttctcatcac ccataactta tatcaagccc agaaagtaac agatgatctg acttcacttc 60241 tagaggatcg gtctgtcctt ttgtaccccg tcaatgaact catttcatca gaaatcgcag 60301 ttgcaagccc tgaattgcgg gcgcagcgat tagatgtcat taatagacta acgaatggag 60361 aagcgccaat tgtcgttgct ccggtagctg caatcagaag aatgctgccg cctgttgagg 60421 tgtggaaaag cagccagatg ctcattcaag taggccatga tattgaacct gaccagcttg 60481 cctcacggct ggtagaggta gggtatgagc ggtctgatat ggtttctgcg cccggggaat 60541 tcagtattcg cgggggaatc attgacattt atccgctgac ttcagagaat ccggtgagaa 60601 ttgaactttt tgacaccgag gtggattcaa tccgcagctt taattcagat gatcagcggt 60661 caattgagac ccttacctcg atcaatatcg gtcccgcgaa ggaattaatt atcagaccgg 60721 aagaaaaagc gcgggcgatg gagaaaatcg atagtggtct tgccgcgagc ttgaaaaaat 60781 taaaggctga caaacaaaaa gaaatacttc atgcgaatat ttctcacgat aaagaacgct 60841 tgtctgaagg ccagacagat caggagctcg tgaagtatct ctcatatttc tatgaaaagc 60901 ctgctagttt actagattat acacctgata atacacttct gattttggat gaagtcagtc 60961 ggattcatga gatggaagaa cagcttcaaa aagaagaagc ggagtttata acaaatcttc 61021 ttgaggaagg gaagattttg catgacattc gtttgtcatt cagcttccaa aaaatagtgg 61081 ctgagcaaaa acggcctctg ctgtactact ctttattttt gcggcatgta caccatacga 61141 gcccgcaaaa tatcgtcaat gtgtcaggcc ggcaaatgca gagtttccat ggccaaatga 61201 acgtgcttgc gggcgaaatg gagcgtttta aaaaatcaaa tttcactgtt gtgttcttag 61261 gagcaaacaa ggaacgtacg cagaaattgt catctgtttt ggctgattat gatatcgagg 61321 ccgccatgac agacagcaaa aaagcgcttg ttcagggaca ggtctatatc atggaaggcg 61381 agctccaatc gggatttgag ctgccgttaa tgaagcttgc cgttatcacg gaagaagaac 61441 tgttcaaaaa ccgtgtaaag aagaagccgc gaaaacagaa gcttaccaat gcagagcgca 61501 tcaaaagcta ttctgagctt caaattggag attatgtcgt tcatattaat cacgggatcg 61561 gaaaatacct ggggattgaa actcttgaaa tcaacggcat tcataaagac tatttaaata 61621 tacattatca gggcagtgac aagctttacg tccctgtaga acaaattgat caggtccaaa 61681 aatatgttgg ctccgaagga aaagagccaa agctgtataa attaggcgga agtgaatgga 61741 agcgggtcaa gaaaaaagta gagacatccg ttcaggatat tgctgatgac ttaattaagc 61801 tgtatgccga aagagaagcg agcaagggct atgcgttttc tcctgaccat gagatgcagc 61861 gtgaattcga atcggctttc ccttatcaag agactgagga tcagctccgt tctattcacg 61921 aaatcaaaaa agacatggaa agagaacgtc cgatggaccg cttgctgtgc ggagatgtgg 61981 gctacggtaa aacagaggtt gccatacgtg ccgcgtttaa ggcgatcggt gacggaaagc 62041 aggtagctct gctcgttccg acaaccattt tggcacagca gcactatgaa accataaaag 62101 agcgcttcca ggactatccg attaatatcg gccttctcag caggttcaga acgagaaaag 62161 aagcaaacga aacaatcaaa gggctgaaaa atggaacggt tgatatcgtc atcgggacgc 62221 atcggctgct atcaaaggat gtcgtgtata aagacttagg gctcctcatc attgatgaag 62281 agcagcgttt cggtgtaacc cataaagaaa agatcaagca aataaaagcc aatgttgatg 62341 tattaacgtt aacagcaacg ccgattccgc gtacgctgca tatgtctatg cttggcgtaa 62401 gggacctttc agtcatcgag actccgccgg aaaatcgctt ccccgtacag acgtatgttg 62461 tggaatataa cggcgctctt gtcagagagg cgattgaacg tgagcttgca cgcggaggcc 62521 aggtctattt cttgtacaac cgggtagagg acattgagcg gaaagcggat gaaatttcaa 62581 tgctagtccc tgacgcgaag gtagcatatg cgcatgggaa aatgacagaa aatgaattag 62641 aaaccgttat gctaagcttc cttgaaggag aatcagacgt tctcgtcagc acaaccatta 62701 tcgaaactgg cgtggacatc ccaaacgtca atacgctgat cgtatttgac gccgacaaga 62761 tgggactttc tcagctttac cagctgcggg ggcgtgtcgg ccgttctaac cgtgtggcgt 62821 atgcgtactt cacgtatcgc cgggataaag tgctgacaga agtggctgaa aaaaggctgc 62881 aggctattaa agaattcaca gagttaggtt ccggttttaa aatcgcaatg cgtgacttaa 62941 cgattcgcgg agccgggaat cttcttggtg cccagcagca tggcttcatc gattcggtcg 63001 gatttgacct ctattcacaa atgctgaagg aggccattga ggagcgtaaa ggagacacag 63061 cgaagacaga gcagtttgaa acagaaattg atgtcgagct tgatgcgtat attccggaaa 63121 cttatattca agacggcaaa cagaaaattg atatgtataa acgcttcagg tctgtggcga 63181 caatcgaaga gaagaatgag cttcaagatg aaatgatcga ccgctttgga aactatccaa 63241 aagaagtcga atacttgttt actgttgcag aaatgaaagt ctatgcgaga caggaacgtg 63301 tcgagctgat taagcaggat aaagatgctg tcagattgac gatttctgaa gaagcaagtg 63361 ctgaaattga cgggcagaag ctgtttgagc ttggcaatca atatggcaga caaatcggac 63421 tgggaatgga agggaaaaaa ctcaaaatct ccatacagac gaaaggccgt agtgctgatg 63481 aatggctcga caccgtgctg ggcatgctga agggcttaaa agatgtgaaa aagcaaacca 63541 tttcatcaac gtaaattttg ttactctctg gtgtatatta catttgatgt gacggatact 63601 aatttcaagc gaggcggaag gtacataaag taactgcttt aggtctttcc cacatgtata 63661 taccatcaaa tgaaagagag gcaccagaga tgaaagcaac cggtatcgta cgtcgtattg 63721 atgacttagg tcgggtcgtg attcctaaag aaattcgaag aactctgaga atcagggaag 63781 gcgatccgct tgagattttt gtagatcgtg acggagaagt gattttgaaa aagtactctc 63841 cgatcagtga gcttggagac tttgcaaagg agtatgcaga cgcgctttac gacagcctcg 63901 gccattcagt gctgatttgt gatcgtgatg tatatattgc cgtgtccggc agctccaaaa 63961 aagattactt aaacaagtca atcagcgaaa tgctggaaag aacaatggat cagcgcagct 64021 ccgtgcttga gagtgatgcg aaatcagtac agcttgtgaa tggaattgat gaggacatga 64081 attcttatac tgtaggccca attgtggcga acggtgatcc gataggtgct gtggtgatct 64141 tttcaaaaga tcagacaatg ggcgaagtag agcataaagc cgttgaaaca gcagctggat 64201 ttttggctcg tcaaatggaa cagtaggtct tattcctttc ttcgaaaata ggtatgtaaa 64261 gaacagctct ccttgggacg ctgttctttt tcatgcgtgc cgaaaaagga atccaagggt 64321 tgggatgtgg tataataacc tcgtttttat ttgtgccgcg gtaatacgtg aaccgtattg 64381 cccctgacgt tgggaaggag cttttggatg gacgattcaa taggcgttaa acggcattgg 64441 atttggcagg gggcttttgt tttaattctg gcaggcgtca tcacaaaaat tttaagcgct 64501 gtttacagag tcccgtttca aaacattgtc ggcgatgttg gattttatat atatcagcag 64561 gtatacccct ttcttggtat tgcggtcatg ctgtccacat caggatttcc agtcattatt 64621 tcaaagctga tgaatgatta tagtgaaaaa aatcatcaca ccatattaaa aatatcagcg 64681 ttgtttttgt ctttaatcgg tattttatta tttctttgtt tatatctggg tgctgttcct 64741 attgcactct ttatgggaga ttcgcatcta gccgtgttaa ttcaagtggc cgcatacgcg 64801 tttctgcttt tcccatttgt cgcgttgcta agaggcggtt ttcaggggcg gcacgaaatg 64861 ctcccttcag ccttatcaca gatgacagag cagtttctgc gtgttgcggt gctcttgggt 64921 ttatcatttt ggctcgtgaa aaagggagcc tcgctttata ctgcgggagc ggcagccgct 64981 tcaggctctc ttgccggaag tttggttgca ttgataatac tggggttttt ttggttcaaa 65041 acgaaaagag acaaccaaac ggataggcaa aacgaaaatg tcatcacaac aaaagaattg 65101 acgaaaaaac tgcttttata ttcggtcaca atttgtgtaa gcagtttgct gcttttgttt 65161 atccagcttg ttgatgcttt gaatttatat gcattgcttt cgggtggtga ggcaagcgaa 65221 gaagcaaaat gcctaaaggg gatctatgat cggggacaac ccttgttgca gctcggttca 65281 gtttttgccg taagcattgc gacgtcactc gttccgtata tttctatggc tgtaaaaaac 65341 aaagagctga agatcatgaa agaaaaaatc acgtcatctt tgaaactatg ccttgtgctc 65401 ggtacaggcg catcggctgg gttgatttgc attctaaagc cggtaaatat catgctgttt 65461 caaaatggag aagggacagg tgcgttacaa gtatttagct gctccatttt gtttgcatcc 65521 ttggcggtaa cggcagcggc agtcttacag ggagcgggat acacagtttt tcctgcgata 65581 gcggtgggcg cgggtgttgc ggtgaaatgg gtgttaaaca cacttttggt tccgcgctat 65641 gggattgaag gcgcatcgct tgcgacagcg gcttcctttg cggctgtcgc cggccttaac 65701 ttgtatcagc ttcggcaaaa ggaatggctc gataagctta gaggcgtttt gattccgatt 65761 attggatctg ctcttttgat gtcagctgtt ttgcttgcgt atacgcgtct ctggactttc 65821 ttgtttcctg caacaggaag aggagcggct gtgattgaga gtctttctgc tgttgccatt 65881 ggtggcgcgg tgtttattta ttgtatgatg agattgggaa tatttacaga tgaagagctg 65941 aacagtgtgc cattcggcag caagttaagc aaattcatga gaaggagaga acaaaatggc 66001 gggtaaaatt acagtcgtcg gacttggtgc cggagacatg gaccaattga caattggtat 66061 acacaagctg ctgacgaagg cagatacgct gtatgtcaga accaaggatc atcctttaat 66121 tgaggagctt gaaaaagaaa cgaagaacat ccgtttcttt gatgatatat atgagaaaca 66181 tgatcagttc gaggcggtat atgaagaaat tgcagatatc ctctttgaag cggcgcggcg 66241 tgaggacgtg gtttacgctg tgccgggaca cccttttgtc gcagaaaaaa cagttcagct 66301 gctgacggag cggcaggaaa aggaaaacgt tcaagtgaaa gtcgcggggg gacaaagttt 66361 ccttgatgcc acattcaatg tcttgcaaat tgacccgatt gaaggttttc aatttgtgga 66421 tgccggcaca ttgtccgcgg atgagcttga gctcagacat catctgatca tatgtcaggt 66481 ttacgaccaa atgacggctt ctgaagtcaa gctgacattg atggagaagc tgcctgatga 66541 ttatgaggtc gtcattgtga ctgcagcagg cagccgtggc gaggagatca ggacagtgcc 66601 attatttgag ctggaccgca atgtcgcttt gaacaactta acaagtgtgt atattccgcc 66661 gattaaagaa gagaagctgc tttatcacga attctccacg ttccgaagca tcatcagaga 66721 gcttcgcgga cctaatggat gtccgtggga taaaaagcag acgcatcagt cattaaagca 66781 gtacatgatt gaagaatgtt atgagcttct cgaagctatt gacgaagaag acacagacca 66841 tatgatcgaa gagcttggcg acgttttgct tcaggtcttg cttcacgcgc aaattggtga 66901 agatgaaggt tatttcacaa ttgatgatgt cataaaagga atcagtgaaa aaatggtccg 66961 aagacatccc catgtgttta aagatgttaa ggttcaggat gaaaacgatg ttttagccaa 67021 ttgggaagat ataaaaaagg ccgaaaaaaa tacatctgaa tcatcattac tagacagcgt 67081 accgaaaacc cttccagctc tttcgaaagc agctaaattg cagaaaaaag cagcgaaggt 67141 cggttttgac tgggaagacg tcagcgatat ttgggaaaag gtaagtgagg aaatgaagga 67201 attttcttct gaggtttctg aagctcctca cgaacacaat cttaaagctg agtttggcga 67261 cattttgttc gcgctggtga atgtagcccg cttctacaaa atagagccag aggaagcgct 67321 gaccatgact aatgacaaat tccggagacg gttctcgtac attgaggaaa cagcgaagga 67381 agagggagtc gagttggctg atatgtccct tgaggacatg gacaaactgt ggaatgaagc 67441 aaaagaaact gagaggagat catagatatg agattagata aatttttgaa agtatcacgg 67501 ctgatcaaac ggcgtacact agcgaaggaa gtagctgacc aaggacgaat ctctattaac 67561 ggaaaccaag ctaaagctag ctctgacgta aaaccgggag atgaactaac ggtccgcttc 67621 ggccaaaagc ttgtaacggt tcaagttaat gaattgaaag acacgacgaa aaaagaagaa 67681 gctgcaaaca tgtacacgat tctaaaagaa gaaaaactcg gcgaataggc ttgttctaaa 67741 aaaacccccc acctcataca atgcagtaat aatgctaaaa gtatcgagga tatgggggct 67801 gaatagatga attcatatta tgatcaaaaa ggttcttcgt ctgttccgga acagcatgat 67861 gtgacaatga aaggccggaa gcatttagat atttctgggg ttaagcatgt ggagagtttt 67921 gataacgaag aattcctgct ggaaacggtg atgggaatgc tctccgtcag aggccaaaac 67981 ctgcagatga aaaatcttga tgtggaaaaa gggattgttt cgattaaagg cagggtattt 68041 gatttagtgt acttagacga acaacaaggg gataaagcta aagggttttt tagcaagttg 68101 tttaaatgac gctgacgaca caattctata caatgctagc gatgtccggt atgggtctct 68161 ggcttggtgc ttcgcttgat acataccggc tctttgtcat tcgtgccaaa acagccagat 68221 ggctattatt tattcatgat attcttttct ggattatgca agggctgctt ttcttttatg 68281 tcttgcttca tgtaaatgag ggagaattca ggatttacat ctttttagcg gttctgctgg 68341 gcgttgcgac gtatcagagc ctttgcaaac gaatctatat aaaaatactg aaattcgtca 68401 tttaccttgt tgtttctgtt tatcaattct tcaaaaaact cattcagcac gtgttatttc 68461 gtcctattgt gtggacatgc ggagcgatca tctggctggc ggcattttta ttcaagaaaa 68521 catacagcct gataggtttt ctcctgctgt gtctatataa aatagtcatg gttctgtgtt 68581 ttccgatccg ttttatcgcg aaacaatgtt tgaaacttct tcctgtgaaa atgcgtctaa 68641 cttttagacg ttattttgaa aaaggtgcag gatttctcaa aaagaagaag aaactattga 68701 taaccataag aacgaccatc acacggtttt tgaagagatg aaaggaggac cgtctggttt 68761 gaatttttcc agggaacgaa cgataactga aatacaaaac gactataaag aacaagtaga 68821 acggcaaaat cagctgaaga aacgaagacg caaagggctg tacagacggt taactgtatt 68881 cggcgcccta gtattcctga cggcaattgt gctggcaagc tctgtatggt cccaaacatc 68941 ttcccttagt gcaaaagaag aaaagaaaga acagcttgaa aaagaactga aaagtttaaa 69001 gacaaaacaa acggatttaa aagaagaaat atccaaattg aaggatgagg attacgtcac 69061 agagcttgcc agaagggact tattcatgtc tggagacgga gaaattatct tcaatgtgga 69121 gaagaagagc aagtagcctt gttgacactt aaatttttat ttaggtataa ttaagcaaac 69181 gatcttttta taagcctaag gaggagcact ttttttatgt cgattgaagt tggcagcaag 69241 ttgcaaggga aaattacagg tattacaaat tttggagcat ttgttgaatt gcctggaggc 69301 tcaaccggtc tcgttcacat tagtgaggta gctgataatt atgtcaaaga cattaacgac 69361 cacttaaaag tcggcgacca agttgaagtg aaagtcatca acgttgaaaa agacgggaaa 69421 attggtttat ctattaaaaa agctaaagac cgtccgcaag ccagacctag aaatgatttc 69481 cgtccgaaag aatcttttga acagaaaatg aataagtttt taaaagacag cgaagatcgc 69541 ttgtcatctt taaaacgcaa tacggaatca aaacgtggag ggcgcggagc aagaagagga 69601 taacttgctg ctttctataa aataaatgaa gcatccgttc atcccgacgg atgctttttt 69661 attatcctca ttctctttaa gagtcagaaa attacaacat taaagtttct gttgacgaaa 69721 gagacaaacc tttgtattat ataacttgtg cttagaagca caaaacaata tggcggtgta 69781 gctcagctgg ctagagcgta cggttcatac ccgtgaggtc gggggttcga tcccctccgc 69841 cgctaccata tttgtttggc ccgttggtca agcggttaag acaccgccct ttcacggcgg 69901 taacacgggt tcgaatcccg tacgggtcat cctaacaaat cggtttctct tgcagaagcc 69961 gatttttttc atttttagac aacattccgg aaattctttt cataaacgaa tatcaaggca 70021 gaaaccgtcg aagatttctt tggtattgtt accttctttt gacaaaatcc tatctgtgct 70081 ttcgctataa tgacaggcaa cgaatataac aggtgggaga tgagaggaat ggaaaaagca 70141 gaaagaagag tgaacgggcc aatggcggga caagctttgg aaaaactcca atcgtttttt 70201 aacaggggca cgaagctggt gactcatcat ttgcattcac tgtttttcta taaaggattc 70261 atttatgttg tcatcggatt tttgcttgga cgggctttca tattatccga ggtgcttcct 70321 ttcgcacttc ctttctttgg agcgatgctt cttatcagaa gagacaaagc gttttatgcg 70381 gttttggctg tgcttgcagg tgcgctgacc atatctccaa agcactcatt gctcatactg 70441 gcggcattgc tggcattctt cgtattttct aaagtggctg ccttcattac cgacgatcgt 70501 gttaaagcgc tcccgattgt cgtgttcttc tccatggctg cagcaagagc cgggtttgtt 70561 tatgcccaaa atggcgtatt tacaacctat gattatgtaa tggctatcgt tgaggctgga 70621 ctatcgttta tcttaacact gattttcctt cagagccttc cgatttttac tgtgaaaaaa 70681 gtgaaacaat cattaaaaat agaggaaatc atttgcttta tgattcttat tgcctctgtt 70741 ttaacggggc tggctggctt gtcctaccaa gggatgcagg cagaacatat attggctcgt 70801 tatgttgtgt tgagtttttc ctttattggc ggagcaagca tcggctgtac ggttggggtt 70861 gtgaccggcc tgattcttgg cttggcgaat atcggaaacc tatatcaaat gagtctgctt 70921 gctttttccg gtttattggg cggtttgctg aaggaaggga aaaaagcggg tgcagcaatt 70981 ggtttgatcg ttggatcact tcttatatct ttatatggtg aaggctctgc cggtctgatg 71041 acaacgctct atgagtcatt aatcgcagtc tgcctgtttt tgctcacacc tcaatctatt 71101 acgaggaaag tggcgagata tattccggga actgtcgagc atcttcaaga gcaacagcaa 71161 tacgctagaa aaatccgtga tgtcactgct cagaaggtag accaattctc caatgtattt 71221 cacgcgctgt ctgaaagctt tgcaaccttt tatcaagcat cagacgaaca gacagatgac 71281 agcgaagttg atctgttctt aagcaaaatc acggagcatt cctgccagac gtgctacaag 71341 aaaaacaggt gctgggtaca gaactttgat aaaacatatg acttaatgaa acaagttatg 71401 cttgaaacag aggaaaaaga atatgcatca aaccgaaggc tgaaaaaaga gtttcaacag 71461 tattgttcta aatccaagca ggttgaagag ctgattgagg atgagctcgc acatcatcat 71521 gcccatttga cactcaagaa aaaagtccaa gacagcaggc gccttgttgc tgaacagctt 71581 ttaggcgttt ctgaggttat ggccgacttt tctcgggaaa taaaaagaga gcgagaacaa 71641 cactttctgc aggaagagca aatcatagaa gcgcttcagc atttcggaat tgagattcag 71701 catgtcgaga tctatagtct tgaacaagga aatatcgata ttgaaatgac cattccgttc 71761 agcggacatg gagaaagtga aaaaatcatt gctcctatgc tttctgacat tctggaggaa 71821 caaattcttg tgaaagccga acagcactct ccgcatccga atggatacag ccatgtcgcc 71881 tttggatcaa caaaatcata cagggtgtcc acgggagctg ctcacgctgc gaagggcggc 71941 ggccttgtct ccggtgacag ctacagcatg atggagcttg gagccagaaa atatgctgca 72001 gcaatcagtg acggaatggg caatggcgca agagcgcact ttgaaagcaa tgaaacgatc 72061 aagcttcttg aaaaaatcct tgaatcgggc attgatgaaa aaatagcaat taaaacgatc 72121 aacagcatac tgtctctaag gacaactgac gaaatatatt ccacgcttga cctatctatt 72181 atcgatcttc aagatgccag ctgtaaattt ttgaaggttg gatcgacgcc cagctttatc 72241 aaacggggtg accaggtcat gaaagttcaa gcgagcaatc tgccaatcgg tattattaat 72301 gaattcgatg tggaggttgt gagtgaacag ctgaaagcgg gtgacctctt aattatgatg 72361 agtgatggca tttttgaggg gcctaagcat gtggaaaatc acgacttatg gatgaagcgt 72421 aaaatgaaag ggttgaaaac aaatgacccg caggagattg ccgatttgct tatggaagaa 72481 gtcatccgca caagatccgg ccaaattgag gacgatatga ctgttgttgt cgtccggatt 72541 gatcacaata caccgaagtg ggcatccatt cctgttccgg caatctttca aaacaaacaa 72601 gaaatttcat aacgcttccg tataaatcaa atttcttctg gcgaagatgg gaatatatga 72661 atctgagaat cctcgtattc tccaggagga atgaatgtga acaacggaca tttaaatcaa 72721 attttgctga taacggatgg ctgctcaaac catggggaag acccgcttgc aatggctgct 72781 tttgctaaag agcaggggat tacggtaaat gtcattggta taatggaaga aaatcaaatt 72841 gaccctgagg caatgaagga agtcgaaggg attgcacttg ccggaggagg cgtgcaccaa 72901 gtcgtttatg catctcagct ttcacaaact gttcaaatgg taacaaagaa agcgatgacg 72961 caaaccttac aaggtgtagt caatcaagaa ctgaaacaga ttctcggaaa gaatgtggaa 73021 atggaagagc tttctccgga aaaacgcggc gaagtcatgg aagtggtaga cgagcttgga 73081 gaaacggtgc atcttcaggt tttggttctt gttgatacaa gtgcaagtat ggcgccaaag 73141 cttccaacag taaaagaggc gctgattgat ttgtctgtaa gcctcaattc ccgaattggg 73201 aataacgaat ttgcgatgtg tatatttccc gggaaaaaac aagaggtcga gcttgtgctg 73261 aactggacac cgaagctgca atctctttcc acactctttg caaagctttc gacaggcggc 73321 atcacgccga caggtccggc gattcgtgaa gcgacactgc agtttgaaaa aatacgctca 73381 agaaggggca tgctggcaga tgatgaacga cgctttgacg agtttggcat gtagcctcaa 73441 gccgggtacg acaatcaaag gcaagtggaa tggaaacact tatacattgc gtaaacagct 73501 tggtaaaggg gccaatggaa ttgtgtattt ggcagaaaca tcagatggac atgttgcctt 73561 aaaggtgagt gatgacagcc tgtctattac ttctgaagtg aatgtcttga aatctttctc 73621 aaaggcccag tccgttacga tggggccttc tttttttgat acggatgatg cctatattcc 73681 cagtgccaat acgaaagttt cattttatgc aatggaatac ataaaagggc cgctgctttt 73741 gaagtatgtc agtgataaag gagcagagtg gataccggta ttaatgattc agctgttatc 73801 cagcttatcg gtgcttcacc agcaaggatg gatattcggc gatcttaaac ctgataatct 73861 gatcgtaact ggtccgcccg caaggatccg ctgcattgat gtgggcggca cgacaaagga 73921 aggccgggcg ataaaagagt atacggagtt ttatgacaga ggctattggg ggtatggaac 73981 aagaaaggca gagccatcct atgatctgtt cgcagttgcc atgattatga tcaacagtgt 74041 gcataaaaaa gaatttaaga aaacgaacca gcccaaagaa cagcttaggt ctctcatcga 74101 aggaaacccg ctgcttcaaa agtataaaaa agcgcttttt tcagccttga acggagatta 74161 tcaatccgca gatgaaatga aaaaggatat gctagacgcg gggcaaaaag cagcacaaag 74221 aaaacagcct ataaaagcat caccgcagcc tgccacacga caaagacagc aaaaaccgcg 74281 ccaaggaaaa ataacgaaga cgcgatatac cccaaaacag aaaccggcta agtcgggggg 74341 gttatttgaa acaacgctta tcgtgatcag tgttttagcg ctttatttcg cctatattat 74401 ctttttctta atctgaatgg tgcaaactgc agagcctatg cttcttcttt gcttggaggg 74461 gttgaaagtg ttaggatatg aatatcttta aaatacctgc tcattgtgag gaggacattg 74521 tgaaaagtgt caaagatttt ttaaacaaac acaatcttac gttaaaaggg gcgacaatca 74581 ttgtaggcgt ttccggcggt ccggactcaa tggctcttct tcacgcgttg catacgttat 74641 gcggccgttc agcgaatgtt attgcagctc acgttgacca tcggttcaga ggtgcggaat 74701 ccgaggagga catgcgtttt gtccaagctt attgtaaagc tgaacagctc gtgtgcgaaa 74761 cggctcaaat caatgtaacc gcatatgcac aggaaaaagg actcaataag caggctgcag 74821 cacgcgattg ccgctaccag ttttttgagg aaatcatgtc gaagcaccaa gcggactatc 74881 tggctcttgc gcatcatggt gatgaccagg ttgaaacaat gcttatgaaa ctggctaagg 74941 gtacgcttgg aacgggactt gcgggaatgc agccggttag acgttttggg acagggcgga 75001 tcatcaggcc gttcttaacc attacaaagg aagagatcct tcactattgc catgaaaacg 75061 gcttgagcta ccggacggat gaaagcaacg ccaaagatga ctacacaaga aacagattca 75121 gaaaaacagt gctcccgttt ttgaagcagg aatctccgga tgtgcataaa aggtttcaga 75181 aagtgagtga agcactgacg gaagatgagc aattcttaca gtcattaacg aaagatgaaa 75241 tgaataaagt aatcacaagc cagtctaata catcagttga aatcaattcc tctcaattgc 75301 ttgccctccc gatgccttta caaagaagag gagttcaact aatattaaac tatctttatg 75361 aaaacgttcc atcatccttt tcagcccatc acattcagca gtttctcgat tgggcggaaa 75421 atggcggtcc ttcaggagta ctggactttc cgaaagggct gaaggtggtc aaatcatatc 75481 agacatgttt gtttacattt gaacaatggc agtgcaaaaa tgttcccttt gaataccaaa 75541 ttagcggagc tgctgatgaa acggcagtgc tccctaatgg atatctgata gaggcaaggc 75601 attatgcgga ctcgcctgaa gaacatggga atgctgtttt tatcacaagt gaaaaaaagg 75661 tgcgatttcc cttaacaatc cggacgagaa aagctggaga ccggatcaaa ctaaaaggga 75721 tgaacggctc aaaaaaggta aaggatatat ttattgataa gaaattgcct ctccaagaaa 75781 gagacaactg gccgattgtg acggacgcaa gcggtgaaat tatctggata cctggcttga 75841 aaaaatcaat ttttgaagat cttgtgattc caaacagcga ccgcattgta ttacaatata 75901 gacagcatga aaagtgtagg gggcaagcaa aatcatgatg aaacatgata tcgagaaagt 75961 actgatctca gaggaagaga tacaaaagaa agtaaaagag ttaggtgcag aattaacgag 76021 cgagtatcaa gatacatttc cgttggcaat cggtgtgtta aaaggagcac ttccttttat 76081 ggcggatctt atcaagcata ttgatacata tttggaaatg gatttcatgg atgtatcaag 76141 ctacggaaat tctacggttt cttctggaga agtaaaaatc attaaagatt tggatacatc 76201 tgtagagggc cgggacatct taattattga agatatcatc gacagtgggt taaccttaag 76261 ttatctcgta gagctcttcc gataccgtaa agcaaaatca attaagattg ttaccctttt 76321 ggataaaccg agcggaagaa aagcggacat caaagcagac tttgtcggtt ttgaagttcc 76381 tgacgcgttt gtagtgggtt acggacttga ttatgctgag cgctatcgca atctgcctta 76441 tatcggagtg ttaaaaccgg cagtttatga aagctgatcg gcagcctgct tccgagatgg 76501 ttattgtttg tattggaatg attttctatg gtactattga acatagttgt gcttactgtg 76561 ggaggaggta aggaatgaat cgggtcttcc gtaataccat tttttattta cttattttat 76621 tagtagtaat cggggttgtg agctacttcc agacctcaaa tccgaaaaca gaaaatatgt 76681 cgtacagtac gttcatcaaa aacctggatg acgggaaagt tgatagcgta tcggttcagc 76741 ctgtcagagg tgtttatgag gtaaaagggc agctgaaaaa ctacgacaaa gatcaatact 76801 ttttgactca tgttcctgaa ggaaagggag cagaccagat atttaacgct ttgaaaaaga 76861 cagacgtaaa ggttgagccc gcgcaagaaa caagcggatg ggtgacgttc ctgacgacca 76921 tcatcccatt tgtcattatc tttattctgt ttttcttcct gctcaatcag gctcaaggcg 76981 gcggcagccg tgtcatgaac tttggcaaga gtaaagcgaa gctgtataca gaggaaaaga 77041 aacgcgtcaa atttaaagac gttgcagggg ctgacgaaga aaagcaagaa cttgttgaag 77101 ttgttgagtt tctgaaagat ccccgcaagt ttgccgagct cggcgccaga ataccgaaag 77161 gcgtgctttt agtcggacct ccgggtaccg gtaaaacatt gcttgccaag gcttgtgcag 77221 gagaagccgg cgtacctttc ttcagcatca gcggatctga tttcgttgaa atgtttgtag 77281 gggtcggtgc ttcccgtgtg cgtgacttgt ttgaaaatgc gaaaaagaat gcgccttgtt 77341 tgatcttcat tgatgaaatt gacgcagtcg gacgccagcg tggcgctggt ctcggcggtg 77401 gacacgatga acgtgaacag acgctaaacc aattgcttgt tgaaatggac ggattcagcg 77461 ctaatgaagg aattatcatc attgctgcga cgaaccgtgc ggacatcttg gacccagcct 77521 tacttcgtcc gggacgtttt gaccgtcaaa tcacagtgga ccgcccagat gtcattggcc 77581 gtgaagctgt attgaaagtc catgcgagaa acaaaccgct ggatgaaacg gttaacctaa 77641 aatcaattgc catgagaaca ccaggcttct caggcgctga cttagaaaac ctcttgaatg 77701 aagctgcgct tgtagcggct cgtcaaaaca agaaaaaaat cgatgcgcgt gatattgacg 77761 aagcgacgga ccgtgtaatt gccggacccg ctaagaagag ccgcgttatc tccaagaaag 77821 aacgcaatat cgtggcttat cacgaaggcg gacacaccgt tatcggtctc gttttagatg 77881 aggcagatat ggttcataaa gtaacgattg ttcctcgggg ccaggctggc ggttatgctg 77941 ttatgctgcc aagagaagac cgttatttcc aaacaaagcc ggagctgctt gataaaattg 78001 tcggcctctt gggcggacgt gttgctgaag agattatctt cggtgaagtc agcacagggg 78061 cgcacaatga cttccagcgt gcgacgaata ttgcaagacg aatggttaca gaattcggta 78121 tgtcagaaaa actgggaccg ttgcaatttg gacagtctca gggcggtcag gtattcttag 78181 gccgtgattt caacaacgaa cagaactaca gtgatcaaat cgcttacgaa attgatcagg 78241 aaattcagcg catcatcaaa gaatgttatg agcgtgcgaa acaaatcctg actgaaaatc 78301 gtgacaagct tgaattgatt gcccaaacgc ttctgaaagt tgaaacgctt gacgctgaac 78361 aaatcaaaca ccttatcgat catggaacat tacctgagcg taatttctca gatgatgaaa 78421 agaacgatga tgtgaaagta aacattctga caaaaacaga agaaaagaaa gacgatacga 78481 aagagtaatt cgctttcttt ctaaaaaaac tgccggctga cgctggcagt ttttttatgt 78541 aaatgattgg ctcagctgcg gcttttacaa tcatccaatt ctggtatcga tttgtttaca 78601 aatgagccgc tgatcgtgta tggtattgta gaatgtttgt aaaaagtaaa gtagagaaac 78661 tattcaaaag tggtgataga ggttgttact ggttatcgat gtggggaaca ccaatactgt 78721 acttggtgta tatcatgatg gaaaattaga atatcactgg cgtatagaaa caagcaggca 78781 taaaacagaa gatgagtttg ggatgatttt gcgctcctta tttgatcact ccgggcttat 78841 gtttgaacag atagatggca ttattatttc gtcagtagtg ccgccaatca tgtttgcgtt 78901 agaaagaatg tgcacaaaat actttcatat cgagcctcaa attgttggtc caggtatgaa 78961 aaccggttta aatataaaat atgacaatcc gaaagaagta ggggcagaca gaatcgtaaa 79021 tgctgtcgct gcgatacact tgtacggcaa tccattaatt gttgtcgatt tcggaaccgc 79081 cacaacgtac tgctatattg atgaaaacaa acaatacatg ggcggggcga ttgcccctgg 79141 gattacaatt tcgacagagg cgctttactc gcgtgcagca aagcttcctc gtatcgaaat 79201 cacccggccc gacaatatta tcggaaaaaa cactgttagc gcgatgcaat ctggaatttt 79261 atttggctat gtcggccaag tggaaggaat cgttaagcga atgaaatggc aggcaaaaca 79321 ggaaccaaag gtcattgcga caggaggcct ggcgccgctc attgcgaacg aatcagattg 79381 tatagacatc gttgatccat tcttaaccct aaaagggctg gaattgattt atgaaagaaa 79441 ccgcgtagga agtgtatagg aggtttagta atggattatt tagtaaaagc acttgcgtat 79501 gacggaaaag ttcgggctta tgcagcgaga acgactgata tggtaaatga ggggcagaga 79561 cgccatggta cgtggccgac agcatccgct gcactaggcc gtacaatgac agcttcactt 79621 atgctcggcg ctatgctgaa gggcgatgat aagctgaccg tgaaaatcga gggcggaggt 79681 ccgatcggag ctattgtagc tgatgccaat gccaaaggag aagtcagagc ctatgtctct 79741 aacccgcaag ttcattttga tttaaatgaa caaggtaagc ttgatgtcag acgtgcggtt 79801 ggaacaaacg gaacgttaag tgtcgtaaaa gatttaggtt tgcgcgagtt cttcacagga 79861 caagtagaaa tcgtttcagg agaattagga gatgatttta cttactatct tgtgtcatct 79921 gagcaggttc cttcatcagt gggcgtaggt gtgctcgtaa atcctgacaa taccattctt 79981 gcggcagggg gctttattat tcagctgatg ccgggaacag atgatgaaac aatcacaaaa 80041 attgaacagc gtctatctca agtagagccg atttctaagc tcatccaaaa agggctgaca 80101 ccagaagaaa ttttagaaga agtcctaggc gagaaacctg agattttgga aacgatgcct 80161 gtcagattcc attgcccttg ttcaaaagaa cggttcgaaa cagccatttt aggactaggc 80221 aaaaaagaaa ttcaagatat gatagaagaa gatggacaag ccgaagcagt atgccatttt 80281 tgtaatgaaa agtacttatt tacaaaagaa gagctggaag ggcttcgtga ccaaactacc 80341 cgctaagctc tttagcgggt ttttaatttg agaaaagggg ctgaaagcag gtttgaaatc 80401 aagaacaatc tggaccatta ttttaggggc gctgttggtt tgctgtattg ctgttgcata 80461 tacgctgacg aaatcccaag ccggcgcatc gtcatccggt gagtctattg cgactatcgg 80521 aggcaagagt gtgacaagag aagaatggct gaaagaaatg gaagatcagt atggtaagtc 80581 aacgcttgaa gatatgatca atgtccgagt tgttgagcag ctggctaaaa agaacaaact 80641 taaaatatcc aaaagcgaag ttgatcgtga gtttttgctg attaaagcgg tcaataattc 80701 cttttacgaa gatgaacata cgacggagaa agagtggaaa gaccaaattc gttataatat 80761 cctccttgag gatttgttaa caagggatat cgatatctca aacaaagaat tggaatcatt 80821 ctataataaa aataaggaac tatatcagtt tgatgattcg tatcgaattc ggcacattgt 80881 tgtaaaagat gaagaagaag caagagaagt cctgaaagaa ctgaaaggcg gatcaagctt 80941 tgaagctgtc gctgccgaaa gatctacaga cagatataca tcaccatacg gcggagattt 81001 aggttttgtc acagaggcat cagacaacat tccatcagca tacattgaag aggcgaaaac 81061 actcaaagag gatgaatggt ctcaggaacc aataaaggtc agcaacggat atgccattat 81121 ccagctgaaa gaaaaactaa aggcaagaac gttctcattt gatgaagtaa aggaccagat 81181 cagacggcaa atcgcaatgg atcagctagg cgataaagcg acagttaaga cactttggaa 81241 agaagccgat gtatcttggt tttatgggga aaaaagtact aagtgattga caaaaaattt 81301 tgaaattgat agattatata cataatacca atacaaatag tcggaaattg aggtgtcgag 81361 aatggtacgt gtagcaaact ccattactga attaattggg aatacgccaa tcgttaaatt 81421 aaatcgcctt gcagatgaaa acagtgcgga tgtatatcta aaacttgaat acatgaaccc 81481 tggaagcagt gtaaaagacc gtatcggttt agctatgatt gaagcggctg aaaaagaagg 81541 aaaattaaaa gccggtaata caatcattga accgacaagc ggaaatactg gaatcgggct 81601 tgcaatggtt gctgctgcta aaggattaaa agccattttg gttatgcctg atacaatgag 81661 catggagcgc cgcaaccttc ttcgcgcata tggtgctgag cttgtgctga ctcctggtgc 81721 ggaaggcatg aaaggtgcta ttaagaaagc tgaagagctt gctgaaaagc acggatactt 81781 tgtgccgcag cagtttaaca acccttctaa ccccgaaatt caccgccaaa caacgggtaa 81841 agaaatcgtt gagcaattcg gtgatgatca gcttgacgca tttgtagccg gaatcggaac 81901 gggcggaacg attacgggag cgggcgaagt gctgaaggaa gcataccctt ccatcaagat 81961 ttatgctgtt gaaccgtcag attccccagt gctttcagga ggaaaaccag gcccccacaa 82021 aattcaggga atcggagcag gattcgtgcc ggacatctta aacactgaag tatatgatga 82081 aatcttccct gtgaagaatg aagaagcatt cgaatatgcc cgcagagctg cacgtgaaga 82141 aggaattctc ggaggcatct catcaggtgc ggcaatttat gctgctcttc aagtagcaaa 82201 aaaactcgga aaaggcaaaa aagtattggc catcattcca agtaacggcg aacgttatct 82261 aagcacgccg ctgtaccaat tcgattaaaa aaagccaaaa ctcccggttc gccgggagtt 82321 tttttatatt tcgtgcatca aatatgccat gtctgcgacg aatgttattc ttggaagaga 82381 aattcacttt tttcactaac aacattgctt tacaattaaa aacaagtaaa aaagaaaata 82441 gaggaatgat acaaatggca caacgcagac cggcaggcaa aaaaatacct tttcaaaaag 82501 actcattctt acaacaattt gagaaacttg cgcaatcccg gaaacatcat gtacttctcg 82561 aaagtgcaag aggcggcaga tatagtatag ccggtcttga tccaattgcg actgtgaaag 82621 gaaaagacgg aataactaca attaagcatg gtgatgagat gctgtttaaa gaaggtgatc 82681 cattacgggc cttccacagc tggtttaaaa cactggaaac agaaacgaat catgagttcc 82741 ctgactttca aggcggggca atcgggtttc tcagctatga ttacgcacgg tacattgaaa 82801 attttaaaat gctctcatta gatgatttag aaacaccaga tatttatttt cttgtttttg 82861 atgatatagc agtttatgac catcaagaag agtctctatg gctgattact catgttaatg 82921 gttctgatca ggaaacagcg gatgtgaagc tatctgagtt agagcagatg tggttgactg 82981 agcttcccgc tgtcacttcg cgagagatga agcctgaaac agctggttct ttcgcggcgc 83041 catttaccga ggatgggttc tcacaagctg tagagaaaat caaacaatac attgccagcg 83101 gagatgtgtt tcaagtcaat ctatcaataa ggcagtcaca gtcactgtct gtccacccat 83161 atcaaattta caaaaccttg agagaagtaa atccttctcc ttatatggcg tatttagaaa 83221 cacctgattt ccaaatcatt tgcggatcgc ctgaactgct tgtcagcaaa aagggcaagc 83281 tattagagac gagaccgatt gcgggcaccc gttccagagg gaaaacaaat gaagaagacg 83341 aggcgcttgc aaacgaattg atacacaatg aaaaagaacg cgcggaacat gtcatgctgg 83401 ttgatcttga gcgaaatgat ctgggaagag tatcacgtta cgggtctgtg cgcgtaaatg 83461 aattcatggc aattgaaaaa tactcgcatg tgatgcacat tgtgtctaat gtccaaggtg 83521 aactgcagga tgggtatgat gctgtagata ttattcatgc tgtgtttccc ggaggaacca 83581 ttactggtgc accgaaagta agaacgatgg aaattataga agaacttgag ccgacacgcc 83641 gagggcttta tactggatct ataggatggt ttggatataa tcacgatctg cagtttaata 83701 tcgtcattcg aaccatttat gcaaccggag ggcaggcatt tatgcagtcc ggtgcaggag 83761 ttgtgattga ttctgttccg aagcacgaat acaaggaatc attcaaaaaa gcttttgcga 83821 tgcaaagagc attagagctg agcgaagaag agacaaaaat tagatgaggt gagcggagaa 83881 atgattttaa tgattgataa ctacgattca ttcacgtaca acttggtaca gtatttgggc 83941 gagcttgggg aagagctggt tgtgaaacgc aatgacagca tcacaatcga tgaaattgaa 84001 gaactgtctc cggactttct gatgatatct cccggaccgt gcagccctga tgaggcggga 84061 atcagcctcg aagcaattaa acatttcgca gggaaaattc ctattttcgg tgtatgtctc 84121 ggacatcagt ccatcgcaca agtgttcggt ggtgatgttg ttagggcaga acggcttatg 84181 cacgggaaaa cctcggatat cgagcatgac ggcaaaacca tttttgaagg gttgaaaaat 84241 ccccttgttg cgacgcgata ccactcgctg atcgtaaaac ctgagacgct gccaagctgt 84301 tttacagtaa cagcacaaac gaaagaagga gaaatcatgg ctattcgcca caatgacctc 84361 ccgatagagg gtgtgcaatt tcacccagag tctattatga cctcctttgg gaaagaaatg 84421 ctcagaaatt ttattgagac atatcgcaag gaagttattg cgtgatgata tatgtgaacg 84481 gccggtatat ggaggagaaa gatgcagttc tttctccttt tgaccatggg tttttatatg 84541 ggatcggtgt tttcgaaacc ttcaggctct acgaaggctg cccgtttttg cttgattggc 84601 atatagagag gcttgaacgc gcgcttaagg atctgcaaat cgaatatact gtttcaaagc 84661 atgagatcct tgagatgctg gacaagctgc ttaagctaaa tgatatcaag gatggcaatg 84721 cccgcgtcag actgaacata tcagcgggaa tcagcgataa aggctttgtc gcccagacgt 84781 acgataagcc caccgtttta tgctttgtga atcagctgaa accagaaagt cttcctttgc 84841 aaaaagaagg aaaggtttta tcgatacgga gaaacactcc agagggatcg ttccggttaa 84901 aatctcatca ttatctaaat aatatgtatg cgaaacggga aattggaaat gatccgcgtg 84961 tcgagggaat tttcttaacg gaggatggag ctgttgcaga gggtatcata tctaatgtct 85021 tctggagaaa aggtcgctgt atctatacgc catcgcttga taccggtatt ctggacggcg 85081 tcacgagacg ttttatcata gaaaatgcaa aggatatcgg cctggagctc aaaacgggcc 85141 gatatgagct agaagctctc ttgacagctg acgaagcgtg gatgacgaac tcggttcttg 85201 aaatcatccc gtttactaaa atagaagaag taaactatgg aagccaaagc ggagaagcaa 85261 cctccgctct tcaattgtta tacaaaaaag aaataaagaa catgattcat gaaaagggag 85321 gaagagcatg gcgcagcaca caatagatca aacacaagta atccacacta agcccagcgc 85381 tttatcatat aaagagaaga cgctggtgat gggaatttta aacgtaacgc ctgactcttt 85441 ctcggacggc ggaaaatatg acagcttgga caaggcgctg ctgcacgcga aagagatgat 85501 cgatgatggt gcccatatca ttgatattgg aggggaatcg acaaggcctg gcgctgagtg 85561 cgtatctgag gatgaggaga tgtccagagt cattccggtg attgagcgga ttacgaaaga 85621 gcttggtgtt cctatttctg tagacacgta caaggcttct gtcgcagatg aagcagtgaa 85681 agccggtgca tccattatca atgatatttg gggagccaaa catgatccga agatggcttc 85741 cgttgcagct gaacataatg ttccaattgt actcatgcat aaccgccctg aaagaaacta 85801 caatgactta ttgccggata tgctgtcgga cttaatggag agtgtaaaaa ttgctgttga 85861 ggccggagta gacgagaaga acattattct tgatcctggt atcggtttcg cgaaaaccta 85921 tcacgataac ttggcagtga tgaacaaact agagattttc agcggattgg gatatccggt 85981 tcttctggca acctcccgaa aaagattcat cggacgtgtt ctggatcttc cgcctgagga 86041 gcgggctgag ggcacaggcg cgactgtgtg tctcggcatt caaaaaggct gtgacattgt 86101 cagggtccat gatgtaaagc aaattgccag aatggcgaaa atgatggacg cgatgctgaa 86161 taagggaggg gtgcaccatg gataaagttt atgtagaagg tatggagttt tacggatatc 86221 acggtgtgtt cacagaagaa aacaaacttg gccagcggtt taaagtcgat ttaaccgctg 86281 agctggattt aagcaaagct ggacagacag acgaccttga gcaaacgatc aactatgctg 86341 agctctatca cgtatgtaaa gatatcgtgg aaggggagcc tgtgaaattg gtggaaacgc 86401 tggcggaacg tattgctggc actgttctcg gaaaatttca gcctgttcag caatgtacgg 86461 tgaaagtgat taagccagac ccgccaattc ccggacacta taaatcagta gcaattgaaa 86521 ttacgagaaa aaagtcatga acaacatagc ttatattgca cttggatcta atattggaga 86581 tagagaaacg tatttaaggc aagcagtggc tttactgcat cagcatgctg cggtgacagt 86641 cactaaagtg tcgtctattt acgaaactga cccggtcgga tacgaagatc aagctcaatt 86701 tttgaatatg gctgttgaaa tcaagacatc attgaaccct tttgaactcc ttgaactgac 86761 gcagcagata gaaaatgaat taggcagaac aagggaagta agatgggggc cgcggacggc 86821 agaccttgac attttgttat ttaatcgtga aaatattgaa acagagcaac taattgttcc 86881 gcatccgaga atgtatgagc gtttgtttgt ccttgcgccg cttgcggaaa tttgccagca 86941 ggttgaaaaa gaggctacaa gcgccgaaac agaccaagaa ggtgtaagag tatggaagca 87001 gaaatctggg gtagacgaat tcgtgcattc agaaagctga aaggttatac tcaagaagga 87061 tttgcaaaag cattaggtat atcagtttct attctcggcg aaattgaacg cggaaaccga 87121 ttgccgtctg ctgccatcat tcaagatgca gcagatgttt taaatataag tgcggacgaa 87181 ttggcgccgc cagaaaaata gaacaaatga aaggaggaga aaaattgttc aaaatcggag 87241 atattcaatt gaaaaaccgg gttgtgctcg cacctatggc tggtgtctgc aactctgcgt 87301 tcagattgac tgtaaaggaa ttcggagccg gattggtatg cgctgaaatg gtcagtgaca 87361 aagcgatcct ttacaacaat gcaagaacaa tgggtatgct ttatattgat gaacgtgaga 87421 aaccactgag ccttcaaatt ttcggaggaa aaaaggaaac ccttgtggaa gcggcgaagt 87481 ttgtagacca aaacacaact gctgatatca ttgatattaa catgggatgt cccgtgccga 87541 agattacaaa atgcgatgcg ggagccaaat ggcttctcga tcctgataag atttacgaaa 87601 tggtttctgc agtagtggat gctgttaata agccagttac agtgaaaatg agaatgggct 87661 gggatgaaga ccacattttc gcagtgaaaa atgcacaggc tgtagaacgt gcgggcggta 87721 aagcagtggc gcttcacggc cgtacgagag tgcagatgta cgaaggaacg gcaaactggg 87781 atatcatcaa agaagtaaaa caatcagtat cgattccggt tatcggaaac ggcgatgtta 87841 agacaccgca ggatgctaag cgtatgctcg atgagacagg agtagacggg gtcatgatcg 87901 gacgcgctgc attgggtaac ccgtggatga tttaccgtac ggttcagtat cttgaaacag 87961 gtaaattaaa agaagagccg caagtacgcg aaaaaatggc cgtatgcaaa ctgcatcttg 88021 accgcctgat tgacttaaaa ggtgaaaacg tagcggtaag agaaatgaga aagcacgctg 88081 catggtatct gaaaggcgtg aaaggcaatg cgaacgttcg taatgaaatc aatcattgcg 88141 agacgagaga agagtttgta cagcttttag atgcatttac ggttgaagtt gaggcaaaag 88201 agcttcaaaa tgcaaaagta ggataatact cacctctatt tgctgctcac tgctagtttt 88261 acgctggcag tttttctgct tttttcatga aacaatatct gtaatggagt gataacaatg 88321 agtcaagaag agcataacca tgaagaattg aatgatcagc tgcaagtcag acgcgataaa 88381 atgaatcagc tgagagataa cggcatcgat ccattcggcg cacgttttga aagaactcat 88441 cagtctcaag aagttatttc ggcatatcaa gatctaacca aagaagagtt agaagaaaaa 88501 gcgattgaag ttacaatcgc aggccgcatg atgacaaaac gcggcaaagg aaaagccggc 88561 tttgcccatc ttcaggattt agaaggccaa atccaaatct acgtaagaaa agacagtgtc 88621 ggtgacgacc aatatgaaat cttcaagtct tctgacctcg gtgatcttat cggcgtaacc 88681 ggaaaagtct tcaaaacaaa tgtaggcgaa ttgtctgtta aagcaacttc ctttgaattg 88741 ctgacaaaag cgcttcgtcc gcttcctgac aaataccatg gtttaaaaga cgttgagcag 88801 cgctaccgtc agcgctatct ggatcttatc gtaaacccag acagcaaaca tacgttcatt 88861 acacgaagca agatcattca agctatgaga aggtaccttg atgatcatgg atacttagaa 88921 gtagaaacac ctacaatgca cagcattcct gggggagctt ctgcacgtcc gtttatcact 88981 caccacaacg cgttagacat tccactctat atgcgtattg ctatcgaact gcacctaaaa 89041 cgtctaattg tcggcggttt agaaaaagta tatgaaatcg gccgtgtttt ccgtaacgaa 89101 ggtgtctcta cacgccataa ccctgaattt acaatgattg agttatatga agcatatgcg 89161 gactataaag atatcatgag cttaactgaa aaccttgtcg ctcatatcgc ccaagaagtg 89221 cttggcacaa ctacgattca atacggggaa gagcaaatcg accttaaacc ggagtggaaa 89281 agaatccata tggttgacgc agtcaaagaa gcgaccggcg ttgatttctg ggaagaggtt 89341 actgttgagc aggcgcgtga atatgcaaaa gaacatgaag tagaaattaa agactctatg 89401 acagtaggcc atatcatcaa cgaattcttc gaacaaaaaa ttgaagaaac gcttattcag 89461 ccaacgttta tttacgggca tcctgtagaa atttctcctc ttgctaagaa aaaccctgag 89521 gacccgcgtt ttacagaccg ttttgagctg tttatcgttg gccgtgaaca tgccaacgcg 89581 tttacagagc tgaatgatcc tattgatcaa agagaacgct ttgaagcgca attaaaagag 89641 cgtgaagccg gtaatgatga agctcattta atggatgaag actttgttga agctctggaa 89701 tacggtatgc cgccaacagg aggtttaggc atcggtatcg accgtctggt tatgctgctg 89761 acgaatgccc cttctattcg cgatgtgctg ttattcccgc aaatgagaca acgctaataa 89821 aaaagagcgg tatcctccat agggaaagga tgccgctctt tttaaatccc ttagtatttc 89881 ttcaaaaaaa ctattgcact attatttact aggtggtata ttattattcg ttgccgctaa 89941 acaaggcgat aacgaaaaaa agaacttcaa aaaaagttat tgacttcact gagtcaacga 90001 gttataataa taaagtcgct tgaacgaagt gaacaaaatg atctttgaaa actaaacaag 90061 acaaaacgta cctgttaatt cagtttttaa aaatcgcaca gcgatgtgcg tagtcagtca 90121 aactacttta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc gtgcctaata 90181 catgcaagtc gagcggacag atgggagctt gctccctgat gttagcggcg gacgggtgag 90241 taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg ggctaatacc 90301 ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta ccacttgcag 90361 atggacccgc ggcgcattag ctagttggtg aggtaatggc tcaccaaggc aacgatgcgt 90421 agccgacctg agagggtgat cggccacact gggactgaga cacggcccag actcctacgg 90481 gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa cgccgcgtga 90541 gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt gccgttcgaa 90601 tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt gccagcagcc 90661 gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg gctcgcaggc 90721 ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat tggaaactgg 90781 ggaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa tgcgtagaga 90841 tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc tgaggagcga 90901 aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa cgatgagtgc 90961 taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc actccgcctg 91021 gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca caagcggtgg 91081 agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac atcctctgac 91141 aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca tggttgtcgt 91201 cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgatcttagt 91261 tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga ggaaggtggg 91321 gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta caatggacag 91381 aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc tcagttcgga 91441 tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg atcagcatgc 91501 cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga gagtttgtaa 91561 cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg acagatgatt 91621 ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac ctcctttcta 91681 aggatatttt acggaatata agaccttggg tcttataaac agaacgttcc ctgtcttgtt 91741 tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa cagtagacat 91801 cacattcaag taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg 91861 gcgcacggtg gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc 91921 ttcggggagc tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc 91981 gtaatggagt ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact 92041 gaaacatcta agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc 92101 gaaacgggat tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg 92161 gagttacaaa ggaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca 92221 gccctgtagt caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga 92281 aattccgtcg gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata 92341 gtgaaccagt accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc 92401 tgaaaccgtg tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta 92461 gaatgaaccg gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg 92521 aaagcgagtc tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta 92581 cccatgtcca gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga 92641 aaagtgcggg gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg 92701 ttctctccga aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg 92761 attggactag gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact 92821 tatccttggg agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga 92881 ccgccagcta aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca 92941 accaggatgt tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg 93001 agtgactctg cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc 93061 ttcgaacagt ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg 93121 agcgcttaga agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac 93181 cgaatgccta aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc 93241 gaggccgaaa ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca 93301 tttgagcaat ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca 93361 agcagttagg ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag 93421 cgaaatatag tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga 93481 gaggtgcccg taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag 93541 agaactctcg ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct 93601 gttagggtgc aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa 93661 cacaggtctc tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga 93721 aggttaagag gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg 93781 ccgtaactat aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac 93841 gaaaggcgca acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg 93901 tgaagatgca ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg 93961 atattgaatg ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca 94021 gcttcggtgg aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc 94081 ccttatcggg cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa 94141 aaggtaacgg aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta 94201 aaggcacaag ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt 94261 agtgatccgg tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg 94321 ataacaggct tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc 94381 ggctcatcgc atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag 94441 cggtacgcga gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg 94501 caggaaattt gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt 94561 gtaccagttg ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg 94621 aaagcatcta agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag 94681 atccctgaaa gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct 94741 gacagatact aatcgatcga ggacttaacc atatttttga atgatgtcac atctgttatc 94801 tagttttgag agaacactct caatttgttt ggtggcgata gcgaagaggt cacacccgtt 94861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 94921 gtgagagtag gacgccgcca agcaattgca cgttagtgca attatggagg attagctcag 94981 ctgggagagc atctgcctta caagcagagg gtcggcggtt cgagcccgtc atcctccacc 95041 attatgccgg tgtagctcaa ttggtagagc aactgacttg taatcagtag gttgggggtt 95101 caagtcctct tgccggcacc acttttatat gatataatac tcaagtctct tgtagaagag 95161 ccattagctc agttggtaga gcatctgact tttaatcaga gggtcgaagg ttcgagtcct 95221 tcatggctca ccattttacg cgggtgtggc ggaattggca gacgcgctag acttaggatc 95281 tagtgtcttt atgacgtggg ggttcaagtc ccttcacccg cattatatag gataacagtt 95341 agaaaaactg gacatcctgt ctgcggaagt agttcagtgg tagaacacca ccttgccaag 95401 gtgggggtcg cgggttcgaa tcccgtcttc cgctccaact ataccatcca cgccggggtg 95461 gtggaattgg cagacacaca ggacttaaaa tcctgcggta ggtgactacc gtgccggttc 95521 aagtccggcc ctcggcatta tgttttgcgc ccgtagctca attggataga gcgtttgact 95581 acggatcaaa aggttagggg ttcgactcct ctcgggcgcg ccatatcttt taatagaata 95641 gataggaaat cgggaagtag ctcagcttgg tagagcacat ggtttgggac catggggtcg 95701 caggttcgaa tcctgtcttc ccgaccattt ttttatgggg ccttagctca gctgggagag 95761 cgcctgcttt gcacgcagga ggtcagcggt tcgatcccgc taggctccac caaaagtttt 95821 taaaaaagtt gttgactttg aagaagtgac gttgtatact aataaagttg ctttaacaaa 95881 gcggacaaac aaaatgatct ttgaaaacta aacaagacaa aacgtacctg ttaattcagt 95941 ttttaaaaat cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat 96001 cctggctcag gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg 96061 gagcttgctc cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta 96121 agactgggat aactccggga aaccggggct aataccggat ggttgtttga accgcatggt 96181 tcaaacataa aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag 96241 ttggtgaggt aacggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc 96301 cacactggga ctgagacacg gcccagactc ctacgggagg cagcagtagg gaatcttccg 96361 caatggacga aagtctgacg gagcaacgcc gcgtgagtga tgaaggtttt cggatcgtaa 96421 agctctgttg ttagggaaga acaagtaccg ttcgaatagg gcggtacctt gacggtacct 96481 aaccagaaag ccacggctaa ctacgtgcca gcagccgcgg taatacgtag gtggcaagcg 96541 ttgtccggaa ttattgggcg taaagggctc gcaggcggtt tcttaagtct gatgtgaaag 96601 cccccggctc aaccggggag ggtcattgga aactggggaa cttgagtgca gaagaggaga 96661 gtggaattcc acgtgtagcg gtgaaatgcg tagagatgtg gaggaacacc agtggcgaag 96721 gcgactctct ggtctgtaac tgacgctgag gagcgaaagc gtggggagcg aacaggatta 96781 gataccctgg tagtccacgc cgtaaacgat gagtgctaag tgttaggggg tttccgcccc 96841 ttagtgctgc agctaacgca ttaagcactc cgcctgggga gtacggtcgc aagactgaaa 96901 ctcaaaggaa ttgacggggg cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa 96961 cgcgaagaac cttaccaggt cttgacatcc tctgacaatc ctagagatag gacgtcccct 97021 tcgggggcag agtgacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg 97081 ttaagtcccg caacgagcgc aacccttgat cttagttgcc agcattcagt tgggcactct 97141 aaggtgactg ccggtgacaa accggaggaa ggtggggatg acgtcaaatc atcatgcccc 97201 ttatgacctg ggctacacac gtgctacaat ggacagaaca aagggcagcg aaaccgcgag 97261 gttaagccaa tcccacaaat ctgttctcag ttcggatcgc agtctgcaac tcgactgcgt 97321 gaagctggaa tcgctagtaa tcgcggatca gcatgccgcg gtgaatacgt tcccgggcct 97381 tgtacacacc gcccgtcaca ccacgagagt ttgtaacacc cgaagtcggt gaggtaacct 97441 tttaggagcc agccgccgaa ggtgggacag atgattgggg tgaagtcgta acaaggtagc 97501 cgtatcggaa ggtgcggctg gatcacctcc tttctaagga tattttacgg aatataagac 97561 cttgggtctt ataaacagaa cgttccctgt cttgtttagt tttgaaggat cattccttcg 97621 aaacgtgttc tttgaaaact agataacagt agacatcaca ttcaagtaat acaagatatc 97681 acatagtgat tctttttaac ggttaagtta gaaagggcgc acggtggatg ccttggcact 97741 aggagccgat gaaggacggg acgaacaccg atatgcttcg gggagctgta agcaagcttt 97801 gatccggaga tttccgaatg gggaaaccca ccactcgtaa tggagtggta tccatatctg 97861 aattcatagg atatgagaag gcagacccgg ggaactgaaa catctaagta cccggaggaa 97921 gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa cgggatcagc ccaaaccaag 97981 aggcttgcct cttggggttg taggacactc tgtacggagt tacaaaggaa cgaggtagat 98041 gaagaggtct ggaaaggccc gccataggag gtaacagccc tgtagtcaaa acttcgttct 98101 ctcctgagtg gatcctgagt acggcggaac acgtgaaatt ccgtcggaat ccgggaggac 98161 catctcccaa ggctaaatac tccctagtga ccgatagtga accagtaccg tgagggaaag 98221 gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa accgtgtgcc tacaagtagt 98281 cagagcccgt taacgggtga tggcgtgcct tttgtagaat gaaccggcga gttacgatcc 98341 cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag cgagtctgaa tagggcgcat 98401 gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca tgtccagggt gaagttcagg 98461 taacactgaa tggaggcccg aacccacgca cgttgaaaag tgcggggatg aggtgtgggt 98521 aggggtgaaa tgccaatcga acctggagat agctggttct ctccgaaata gctttagggc 98581 tagcctcaag gtaagagtct tggaggtaga gcactgattg gactaggggc ccctaccggg 98641 ttaccgaatt cagtcaaact ccgaatgcca atgacttatc cttgggagtc agactgcgag 98701 tgataagatc cgtagtcgaa agggaaacag cccagaccgc cagctaaggt cccaaagtat 98761 acgttaagtg gaaaaggatg tggagttgct tagacaacca ggatgttggc ttagaagcag 98821 ccaccattta aagagtgcgt aatagctcac tggtcgagtg actctgcgcc gaaaatgtac 98881 cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg aacagtggta ggagagcgtt 98941 ctaagggctg tgaagccaga ccggaaggac tggtggagcg cttagaagtg agaatgccgg 99001 tatgagtagc gaaagagggg tgagaatccc ctccaccgaa tgcctaaggt ttcctgagga 99061 aggctcgtcc gctcagggtt agtcgggacc taagccgagg ccgaaaggcg taggcgatgg 99121 acaacaggtt gatattcctg taccacctcc tcaccatttg agcaatgggg ggacgcagga 99181 ggatagggta agcgcggtat tggatatccg cgtccaagca gttaggctgg gaaataggca 99241 aatccgtttc ccataaggct gagctgtgat ggcgagcgaa atatagtagc gaagttcctg 99301 attccacact gccaagaaaa gcctctagcg aggtgagagg tgcccgtacc gcaaaccgac 99361 acaggtaggc gaggagagaa tcctaaggtg atcgagagaa ctctcgttaa ggaactcggc 99421 aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta gggtgcaagc ccgagagagc 99481 cgcagtgaat aggcccaggc gactgtttag caaaaacaca ggtctctgcg aagccgtaag 99541 gcgaagtata ggggctgacg cctgcccggt gctggaaggt taagaggagc gcttagcgta 99601 agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt aactataacg gtcctaaggt 99661 agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa ggcgcaacga tctgggcact 99721 gtctcaacga gagactcggt gaaattatag tacctgtgaa gatgcaggtt acccgcgaca 99781 ggacggaaag accccgtgga gctttactgc agcctgatat tgaatgttgg tacagcttgt 99841 acaggatagg taggagcctt ggaaaccgga gcgccagctt tggtggaggc atcggtggga 99901 tactaccctg gctgtattga ccttctaacc cgccgccctt atcgggcggg gagacagtgt 99961 caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg taacggaggc gcccaaaggt 100021 tccctcagaa tggttggaaa tcattcgcag agtgtaaagg cacaagggag cttgactgcg 100081 agacctacaa gtcgagcagg gacgaaagtc gggcttagtg atccggtggt tccgcatgga 100141 agggccatcg ctcaacggat aaaagctacc ccggggataa caggcttatc tcccccaaga 100201 gtccacatcg acggggaggt ttggcacctc gatgtcggct catcgcatcc tggggctgta 100261 gtcggtccca agggttgggc tgttcgccca ttaaagcggt acgcgagctg ggttcagaac 100321 gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg aaatttgaga ggagctgtcc 100381 ttagtacgag aggaccggga tggacgcacc gctggtgtac cagttgttct gccaagggca 100441 tcgctgggta gctatgtgcg gacgggataa gtgctgaaag catctaagca tgaagccccc 100501 ctcaagatga gatttcccat tccgcaagga agtaagatcc ctgaaagatg atcaggttga 100561 taggtctgag gtggaagtgt ggcgacacat ggagctgaca gatactaatc gatcgaggac 100621 ttaaccatat ttttgaatga tgtcacatct gttatctagt tttgagagaa cactctcaat 100681 ttgtttggtg gcgatagcga agaggtcaca cccgttccca taccgaacac ggaagttaag 100741 ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggacg ccgccaagca 100801 agcttaaacc cagctcaatg agctgggttt tttgtatttt ggtttattgg tatcataaaa 100861 ttccacttaa ctgtataata taataacttt ataccgaatt ttaaatcagc aatcaggttt 100921 tgtggaccgg gaaaatggaa ataatgaagg atagagcgag aaagttgaaa attctcgaga 100981 aacggcttat agtaagatta aagtcaaata tagtcaaagt cagtaaagga gggggttgag 101041 tgggacataa tatttctgac atcattgaac aatatttaaa acgagtgtta gatcaaaatg 101101 gcaaggaaat tttagagatt aaacgaagtg aaattgcaga taaatttcaa tgcgttcctt 101161 cccaaataaa ttatgtcatc aacaccagat ttacaagcga aagaggatat attgttgaga 101221 gcaaacgcgg gggcggcggt tacatcagaa tcattaaaat taaaatgaac aatgaagttg 101281 tcctgatcaa taatataatt tctcaaatta atacccattt gtctcaagca gcctctgatg 101341 acattatttt aaggctatta gaagacaagg taatttcaga aagagaagca aaaatgatgg 101401 tcagcgtaat ggaccgctca gttttacaca ttgacttacc tgaacgtgat gaattaagag 101461 cgagaatgat gaaggcaatg ctgacttctt taaaattaaa ataagcgggt gaaaagattg 101521 atttgtcaag agtgccacga gagaccagcc acttttcact ttacaaaggt tgttaacgga 101581 gaaaaaatag aagttcatat ttgtgaacaa tgtgccaaag aaaatagtga ttcatatggt 101641 ataagtgcaa atcagggttt ctctattcat aatttacttt cgggtttact gaacatggat 101701 tcttcatttc aaaatgcagg aactcaaatg ttcagtcact cggagcaaat atctgcttgt 101761 ccgaaatgcg gaatgacttt tcagcaattc agaaaaattg gccgttttgg atgttctgaa 101821 tgttacaaaa catttcatag caacattaca ccaatcctac gtaaagtgca cagcggaaac 101881 actgtgcatg caggtaagat accgaaacga ataggcggca atcttcatgt cagacggcag 101941 attgatatgc taaaaaagga attagaatcc ttaatccatc aagaagaatt tgaaaatgca 102001 gctcatgtaa gagatcaaat tcgtttatta gaacaatcac tcaaaagtac agatagtgag 102061 gaggaacagg agtaatgtcg ctaaagcatt ttattcagga cgcactaagc agttggatga 102121 agcagaaagg acctgaaagt gacattgtac tcagcagccg catacgttta gcaagaaact 102181 ttgagcatat tcggttccct acgcggtatt ccaatgaaga agcctcatcc atcatacagc 102241 aatttgaaga tcagttttca gagcaagaaa ttcccggaat cggcaaattt gttttgatta 102301 gaatgaatga tgcacagcct ttagaaaagc gtgtacttgt tgaaaaacat ctaatcagcc 102361 cgaatttgac agagtctcct tttggcggct gtttgctttc tgaaaatgag gaagtaagcg 102421 tcatgctaaa tgaagaggac catattagaa ttcagtgtct tttccctgga tttcagcttt 102481 tagaagcaat gaaagccgca aaccaggtcg acgactggat tgaagaaaaa gttgattatg 102541 cattcaatga gcaaagagga tacttaacca gctgtcctac aaacgtaggt actggtttaa 102601 gggcttcggt catgatgcat ctgccggcgc tggttttaac taggcaaata aatcgaatta 102661 taccggcaat taatcaatta ggcttagttg ttagaggaat ttatggggaa ggcagcgaag 102721 cagtagggaa tatctttcaa atttcaaatc agatcacgct tggtaagtca gagcaggata 102781 ttgtagagga tcttaacagt gttgctgctc agttgattga acaagaacga tctgcccgag 102841 aagcgattta tcaaacttct aaaatcgaac ttgaggatcg ggtatatcgg tcatatgggg 102901 tcttgtctaa ttgccggatg atagaatcga aagaaactgc aaagtgcctt tcagatgttc 102961 ggttaggcat agacttaggc ataataaaag gactttcaag caacatactt aacgaactta 103021 tgattttgac gcagccaggg tttttacagc aatactcggg aggcgctttg cgaccgaacg 103081 aaagggacat tcgaagagcg gctctcatca gagaacggct tcacttagaa atgaatggga 103141 aaagacagga ggatgaatcg atatgatgtt tggaagattt acagaacgag ctcaaaaagt 103201 actggcgcta gcacaggaag aagcacttcg gttaggtcat aataacattg gcactgagca 103261 tattttatta ggactggtaa gagaaggaga gggcattgct gctaaagctc ttcaagcgct 103321 tggactcggt tcagaaaaaa ttcagaaaga agtagaaagt ttgatcgggc gcgggcagga 103381 aatgtctcaa acgattcatt atactcctag agctaaaaaa gtcattgagc tttcaatgga 103441 tgaggcaaga aaactcggtc attcttatgt gggaacagaa catattcttc ttggtctgat 103501 tcgtgaagga gaaggtgttg ctgcgagagt tctgaataat ctcggtgtca gcttaaataa 103561 agcaagacag caggtgctcc agcttctagg aagtaatgaa acaggatcat cagcggcagg 103621 aacaaacagc aatgcgaata cgcctacgct tgacagcttg gcaagagact taactgctat 103681 tgcgaaggaa gacagccttg accctgtaat cggcagaagc aaggagatcc agcgtgtcat 103741 tgaagtgtta agccgcagaa cgaaaaacaa ccctgttctc attggggaac caggtgtagg 103801 taaaacggct atcgcagaag gtttggcaca gcaaattatc aataatgaag tacccgaaat 103861 tttgcgtgat aaacgtgtga tgacattaga catgggaaca gttgttgccg gcacaaaata 103921 ccgcggagaa tttgaggatc gcctgaagaa ggtcatggat gaaattcgcc aggcaggaaa 103981 tatcattcta ttcatcgatg agctccatac attaatcggg gcaggcggag cagaaggtgc 104041 tattgatgca tctaatattt taaaaccttc acttgctcgt ggcgaactcc aatgtattgg 104101 tgcaacgact cttgatgagt accgtaaata tattgaaaaa gatgcagcac tggaacgccg 104161 ttttcagccg attcaggttg atcagccatc tgtagatgaa agtattcaaa ttttacaagg 104221 tctgcgtgac agatacgaag cccaccaccg cgtttctatc actgatgatg ccattgaagc 104281 tgcggttaag ctttctgaca gatatatttc tgaccgcttc cttccggata aagcaattga 104341 cttgatcgat gaagcgggtt caaaggtgag actgcgctca tttacaacgc ctcctaactt 104401 aaaagagctt gagcagaagc ttgatgaggt tcgtaaagag aaggatgcgg cagtgcaaag 104461 ccaagagttt gaaaaagctg cttccttgcg tgatactgaa caacgcctgc gcgagcaagt 104521 agaggatacg aagaaatcat ggaaagagaa gcaagggcag gaaaactcag aggttactgt 104581 ggatgatatt gcgatggttg tatccagctg gaccggtgtg cctgtatcta aaatcgccca 104641 aactgaaact gataagcttc tcaatatgga aaacattctt cactcccgtg tcatcggcca 104701 ggatgaagca gttgtagcgg ttgcaaaagc cgtcagacgt gcaagagcag gattgaaaga 104761 tcctaaacgc ccaatcggct cattcatttt cttaggccct acaggtgtag gtaaaacaga 104821 acttgcacga gcacttgctg aatccatttt tggcgatgaa gaatccatga tcagaattga 104881 tatgtctgaa tacatggaaa aacattcaac ttcaagactt gttggttcac ctccgggtta 104941 tgtgggatat gatgaaggcg gtcaattgac agagaaagtc agaagaaaac cttactctgt 105001 cgtgcttctt gatgagatcg agaaagcgca ccctgatgtc ttcaatatcc ttctgcaagt 105061 tcttgaagac ggacgattga ctgattctaa aggacgcaca gtcgatttcc gcaataccat 105121 tctgatcatg acatcaaacg tcggagcaag tgagctaaaa cgcaataaat atgtcggctt 105181 taacgttcag gatgaaactc aaaatcataa agacatgaaa gataaagtga tgggtgaatt 105241 aaaacgagcg ttcagacctg agttcatcaa ccgtattgat gaaatcattg tcttccattc 105301 acttgagaaa aaacatctca ctgagattgt gtcattaatg tctgatcaat taacgaaacg 105361 cctgaaagaa caagatcttt ctatcgaatt gacagatgct gcaaaagcga aagtcgcgga 105421 agagggcgtt gacctggaat acggtgcccg tccgttaaga agagcgatcc aaaaacatgt 105481 cgaggatcgt ttatctgaag aactcctcag aggaaatatt cataaaggac agcatattgt 105541 tcttgatgta gaagatggcg aatttgtcgt aaaaacgact gctaaaacga attaatatag 105601 aagacggaaa tgaggcatac agcatgtaag tgtatgcctc actttcatat caagaaatag 105661 aacaagggag aggtcttaca ctatatatgg ctaaaacaaa atcgaagttc atctgccaat 105721 cctgcggcta cgagtctcca aaatggatgg ggaaatgtcc gggctgtggt gcttggaata 105781 caatggtgga agaaatgatt aaaaaagcac cggccaatcg gagagcggct ttttctcatt 105841 ctgttcaaac tgtacagaaa ccttcaccta ttacatcaat cgaaacatca gaagaacccc 105901 gcgtcaaaac ccagcttggc gagtttaaca gagtactcgg cggaggtgtc gttaaaggct 105961 ccctcgtttt aattggcggt gatcctggta tcggaaagtc aacgctatta ctgcaggttt 106021 ccgctcaatt atcaggctca tcaaacagtg tcctgtatat ttcgggagaa gaatctgtaa 106081 agcaaacgaa gctgcgagca gaccgtctcg gcattaataa tccgtcactg catgttttat 106141 ctgaaaccga tatggagtat atttcgtctg ctatacaaga gatgaatcca tcgtttgtcg 106201 ttgttgactc tattcaaacg gtttaccaaa gcgatattac atctgctcca ggcagtgtgt 106261 cacaggtcag agaatgtacc gctgagctga tgaaaattgc aaaaacaaaa ggtattccga 106321 tttttatcgt agggcacgtg acgaaagaag ggtctattgc aggtccgaga ctgttggagc 106381 atatggttga cactgtttta tattttgaag gagaacgcca ccatactttc cgtattttgc 106441 gggctgtaaa aaaccgtttc ggatctacaa acgaaatggg cattttcgaa atgcgggaag 106501 aggggctcac tgaggttttg aatccttcgg aaattttctt agaagaacgc tctgctggtt 106561 ccgcaggctc gagtatcact gcctctatgg agggcactag accgattctc gttgaaattc 106621 aggcactcat ctcgccaaca agttttggca acccaaggcg tatggcaacg ggaatagacc 106681 ataacagggt ttctctgtta atggctgtgt tagaaaaaag agttggactg ctgctgcaaa 106741 atcaggatgc ttatttgaaa gtggctggcg gcgttaagct tgatgaaccg gcaattgatc 106801 ttgcgattgt gattagtatt gcatcaagct ttagagacac acctccaaat cctgcagatt 106861 gttttattgg agaagtggga ttaaccggag aagtccggcg ggtttcaaga attgaacagc 106921 gtgtgaaaga agcggcaaag cttggtttta aacgcatgat catacccgcg gcaaatctgg 106981 atggatggac aaaaccaaaa gggattgagg ttatcggagt agcaaatgtt gcagaagcgc 107041 ttcgtacttc attaggagga taatagatgg aaaaagagaa aaaaggggcg aaacacgagt 107101 tagacctgtc atctatattg cagtttgttg ctccgggtac accgctcaga gcggggatgg 107161 aaaacgtctt gagagcaaat acaggcggtc tgattgttgt tggatataat gataaagtaa 107221 aagaagtggt ggacggcggc tttcacataa acacggcttt ttctccggcg catttatatg 107281 agctggctaa aatggatgga gcgatcattt taagtgattc tggtcaaaag atcctatacg 107341 cgaatactca gctgatgccg gatgccacaa tttcttcatc agaaacagga atgcggcaca 107401 gaactgccga aagagtagct aagcaaactg gctgtcttgt aatcgccatt tctgaaagaa 107461 gaaatgtcat aacgttatat caggaaaaca tgaagtatac actaaaagac ataggattta 107521 ttttaaccaa ggcgaaccaa gccattcaaa cacttgaaaa atataagaca atcctcgata 107581 aaacgattaa tgcactgaac gcgttagagt ttgaggaact tgttaccttc agtgatgtct 107641 tgtctgtcat gcatcgttat gaaatggtac tgagaatcaa aaacgaaatt aatatgtata 107701 tcaaagagct ggggacagaa gggcatctga tcaaactgca agtcattgaa ttgattacgg 107761 atatggaaga agaggccgct ttatttatta aggactatgt aaaagaaaag attaaagatc 107821 cgtttgttct cttgaaggag ctgcaggata tgtccagtta tgatctgctg gatgattcca 107881 ttgtgtataa gcttctcggt taccctgctt ctactaatct tgatgattat gtattgccga 107941 gaggatacag gctgttaaat aagataccgc gtcttccgat gccgattgtt gaaaatgttg 108001 tagaagcatt tggagtcctg ccaaggatta ttgaggcgag tgcagaagaa ttagatgaag 108061 tagagggaat cggtgaagta cgagcccaaa aaatcaaaaa aggattaaaa cgcctgcaag 108121 agaagcatta tttagacaga caactgtgat ttcggttaaa accttatgaa tacgggtata 108181 ttaatgttgg tttttgttta ttctgatatt cgtaggatgc ataagacttt gtgaaattaa 108241 aatgttaaaa aaggaggtgg gggtatgtta aaacgaatag ttcaggcgtt cttcattatt 108301 tttggcggcg ttgttggtat atttttgata cctgaattgt ttgtactgtt aaatatacag 108361 gacatacctt taataacaaa cgcatatacg tctgcggcaa taggagcaat tatctttttt 108421 ctcatcagta tatggggtac agaatacgtt gtgaactggg tgaagtggat agaggattca 108481 ttgttaaaag cgccggttcc agatttgtta tttggaagtc ttggcttagt ttttggactt 108541 ataattgctt atcttatcgt aaatgttatt cctttagaca atatacctta ccgcatattc 108601 agcacaataa ttcctgtatt tttggctttc ttcctcggtt atctcggctt ccaggtgggc 108661 tttaagaaaa aggatgaatt gatcagcctg ttttccattt ccgccagaat gcaaaagaaa 108721 aaaggaacag ctgatgaaga acatgaggtt caagacaaga agctgaaaat tttggacact 108781 agtgttatta ttgatgggag aatagcagat atttgtcaga ctggtttttt agagggagtt 108841 atcgtgattc cgcagtttgt ccttgaggaa ttgcagcata ttgcagactc ttcagatgtt 108901 ttaaaacgaa acagaggacg ccgcggtctt gatatcctga accgcattca gaaagaatta 108961 gacattgaag ttgaaattta cgaaggcgac tttgaagata ttcaggaggt tgacagcaag 109021 ctcgtcaaac ttgctaagct gacatccggg gtcgttgtga cgaatgattt taatttaaat 109081 aaagtgtgcg agcttcagaa ggtagcagta ttaaacatta atgaccttgc caatgcggtt 109141 aagcctgttg tgcttcctgg cgaggaaatg aatgttcagg tcattaagga cgggaaagag 109201 cataatcagg gagttgccta cttggatgac ggtacgatga ttgtcgttga agaaggacgg 109261 aattatatcg gcaagcatat tgatgtactc gtcacaagtg tgctgcagac agcagcggga 109321 cgaatgattt ttgcgaagcc taagctgttg gagaaggcgc tgtaaaggga gaagaaacaa 109381 tgagttatga tgtggtgatt cctgcagccg gacagggaaa gcggatgaag gcagggagaa 109441 ataaactgtt cattgagctg aagggagacc cggtgatcat acacacgtta agagtgtttg 109501 acagccaccg gcagtgcgat aaaatcattt tggtgattaa cgagcaggag cgggagcact 109561 ttcagcaatt gctgtccgat tacccgtttc aaacttcaat tgagcttgtt gcaggcggag 109621 atgagcgaca gcacagtgtg tataaggggc tgaaagccgt aaagcaggaa aagattgtcc 109681 ttgtacatga cggtgcccgt ccatttataa aacatgaaca aattgacgaa ctgatcgcag 109741 aggcggaaca gacaggagcg gccatccttg ctgttccggt aaaagatacg attaaacgcg 109801 ttcaagattt acaagtcagt gagacgattg aacgttcaag cttgtgggct gtccaaacgc 109861 cacaagcttt tcgtctttct ttattgatga aggctcacgc tgaggccgag cgcaagggat 109921 ttttagggac ggatgacgcc agcctcgttg aacagatgga gggcggttcg gtccgtgttg 109981 tagaaggcag ctatacaaat attaagctga cgacgccaga cgatttgacg tcagctgaag 110041 ctatcatgga atcagaaagt gggaataaac atgtttagaa ttggacaagg atttgatgtg 110101 catcaattag tggagggccg tcctctcatt attggcggaa ttgaaatccc gtacgaaaaa 110161 gggctgcttg gccattctga tgcagacgta ttgttgcata ccgtcgctga cgcctgcctg 110221 ggagctgtgg gtgaaggaga cataggcaag cattttcctg acacagatcc cgagttcaag 110281 gacgcagatt ctttcaaatt acttcagcat gtctggggaa tcgtgaaaca gaaggggtat 110341 gtccttggga acattgattg caccatcata gcgcaaaagc cgaagatgct gccgtacata 110401 gaagatatga gaaaaagaat tgctgaaggc cttgaggcag atgtttctca agtaaatgta 110461 aaagcaacaa cgacagaaaa gcttggattt acaggccggg cggaaggaat agcggctcag 110521 gcgacagtac tgatacaaaa aggctaactt gttttgatgc cgggtctatt tggtggtaga 110581 atagattcat acatttttgc ctgaggccat acatgacatg aaaggaagta tttgaaaatg 110641 ggaaacgaag tacgcgtccg ttatgcaccg agtccaaccg gacatttgca tattggaaat 110701 gccagaacgg cgctttttaa ttatttattt gcccgcaatc aaggcggtaa gtttatcatt 110761 cgagttgagg atactgataa aaagcgcaat attgagggcg gagaacaaag ccagctgaat 110821 tatctgaagt ggctaggtat tgactgggat gagagtgtgg atgtcggagg agagtacggt 110881 ccataccgtc agtcagagcg taacgatatc tataaagtgt actatgaaga gcttcttgaa 110941 aaagggcttg cttataaatg ttactgtacg gaagaagagc ttgaaaaaga gcgtgaagaa 111001 cagattgccc gcggagaaat gcctcgttat tccggaaaac acagagacct gactcaggaa 111061 gaacaggaga aatttatcgc cgaaggcaga aaaccaagta ttcgtttccg tgtgccggaa 111121 ggaaaagtca tcgccttcaa cgacatcgta aaaggcgaaa tttcttttga atcagatggc 111181 atcggcgact tcgttattgt gaaaaaggac ggaacgccta cttataactt cgcggtagct 111241 attgatgact acttaatgaa aatgacacac gtgctgcgcg gtgaggatca tatttctaac 111301 acaccgaaac agattatgat ctatcaagca ttcgggtggg atattcctca gttcggacac 111361 atgacgctga ttgtaaacga aagccgtaaa aagctcagca aacgtgatga atccattatt 111421 caattcatcg agcagtacaa agagcttggc tacctgccag aagcgctgtt caactttatc 111481 ggcttgttag gctggtcacc ggttggagaa gaagagcttt tcacaaaaga gcagtttatt 111541 gaaatttttg atgtaaatcg tttatctaaa tcaccagctt tgtttgatat gcataagcta 111601 aaatgggtta acaaccaata tgtgaagaag ctggatcttg atcaggttgt tgaactgacg 111661 cttccgcatt tgcaaaaagc cggcaaagtt ggcactgagc tttctgctga agaacaagaa 111721 tgggttcgta aactgatttc cctgtatcat gagcaattaa gctacggtgc ggaaattgtt 111781 gagctgactg atttgttctt tacggatgag atcgagtata atcaagaagc gaaagctgtt 111841 ctggaagaag aacaggttcc tgaagtgctc agcacattcg cagcgaagct tgaagagctt 111901 gaggagttca ctccggataa tatcaaagca tcgatcaaag cagtgcagaa agaaactggc 111961 cataaaggga aaaaactgtt tatgccgatt cgtgttgctg taacagggca aactcacggt 112021 ccggaactgc cgcaatcaat tgaattgatc ggtaaagaga ctgcaattca gcgtttaaag 112081 aatatctaaa taaatgattg ttgacaggga agagtataaa gctttaggcc attacagaaa 112141 ggatcttcat tggctgagag agatccatga gccgggtttt agaagtgcgc ccttaagacc 112201 tttgaagaac gttttttgaa atcagtattc aaaggcggcc gccgccgtta caggctgaag 112261 ttgggagagc agaagtctgc ttttcaaaca gagtggaacc gcgcggttaa agcgtctctg 112321 tcatgtttac atgcagagac gcttttttta ttgggtagag gaaatcagat agagaaacgg 112381 ggggaagcat gtgtttttta gaatgctcaa agaagacatt gatactgtgt tcgatcaaga 112441 tcccgcagca agaagctatt ttgaagtgat tttaacttat tccggtttac atgctatatg 112501 ggcgcatcgg attgcacatg ctttatataa acgaaaattt tatttccttg cacgccttat 112561 atctcaagta agccgatttt ttaccgggat agaaatccac cccggcgcta caatcgggag 112621 aagatttttc atagaccacg gcatgggggt tgtcattggg gagacatgtg aaatcggcaa 112681 taacgtaacc gtttttcagg gggttaccct cgggggaacg ggaaaagaaa agggaaaaag 112741 gcacccaacg attaaagatg acgcattgat agccacaggt gctaaagtgc tcggttctat 112801 tacggtcggt gaaggctcaa agattggcgc tggttcagta gtgctgcatg atgttcctga 112861 tttttcaaca gttgtcggta tccctggacg ggtcgttgta caaaatggca agaaagtaag 112921 acgcgattta aaccatcagg atttgcccga tccagttgct gaccgcttta agtctttgga 112981 acagcagatt ttagagctga aggcagaact tgaagacaga aaagaaagga tcaatcaaaa 113041 atgacaatca cactttataa tacattgact agacagaagg aaacattcgt tcctcttgaa 113101 gagggaaaag tgaaaatgta tgtatgcgga cccacggttt acaattacat tcatatcggg 113161 aacgcgcgtc cggcaatcgt ttacgatacg gttcgaaact atttagagta taaaggctat 113221 gatgtgcagt atgtctctaa cttcacagac gtagacgata aattaattaa agcggcaaat 113281 gaactcggtg aggatgtacc caccatttca gagcgtttta ttaaagcata ctttgaagac 113341 gtaggtgcgc tcggctgccg aaaagccgac cttcatccgc gagtaatgga gaacatggat 113401 gccattatcg aattcgtaga tcagctcgtg aaaaagggct acgcatatga atcagaaggt 113461 gacgtatatt tcaaaaccag agcatttgaa gggtacggaa agctttctca gcaatcaatc 113521 gatgaactaa gatcaggtgc acgcatccgg gtcggcgaga aaaaagaaga tgctcttgat 113581 ttcgcactgt ggaaagcggc aaaagaagga gaaatctctt gggatagccc ttgggggaaa 113641 gggcgtccgg gctggcacat tgaatgctca gcaatggtga aaaagtatct cggtgaccag 113701 attgatatcc atgcgggcgg acaggattta acattccctc accatgaaaa cgaaattgcg 113761 caatctgagg cgctgacagg caaaacgttt gcgaagtact ggcttcataa tggttatatc 113821 aatattgata atgaaaaaat gtcaaaatca ctaggcaact ttgtgcttgt gcatgacatc 113881 attaaacagc atgatccgca gcttttgaga ttctttatgc tatctgttca ttatcgccat 113941 ccgattaact attcagaaga gcttctggag aatacgaaaa gcgcgttcag ccgtttaaaa 114001 acagcgtaca gcaatcttca gcaccgtctg aacagcagta cgaatttaac cgaagatgac 114061 gatcaatggc ttgaaaaggt tgaagaacac cgcaaagcat tcgaagaaga gatggacgat 114121 gattttaata cggcgaatgc catttcagtc ttgtttgact tagcgaaaca cgccaattat 114181 tatcttcaga aagatcatac ggctgatcat gtgattacgg cgtttattga gatgtttgac 114241 cgcattgttt ctgtcctcgg tttttcgttg ggtgagcagg aacttctcga tcaagagatt 114301 gaagacttaa tcgaaaagcg aaatgaagcg cgccggaatc gcgattttgc attgtcagac 114361 cagatccgcg accagctgaa aagcatgaat atcattcttg aagatacggc tcaaggcact 114421 cgctggaaac ggggagaata acagatgctt gaatttgata cgataaaaga ttctaagcag 114481 cttaacggtc ttgcgcttgc ttatataggt gatgccattt ttgaagtgta tgtcaggcat 114541 cacctgctta agcagggctt taccaaacca aatgatcttc ataagaaatc aagccggatt 114601 gtttcagcaa agtcacaggc tgagatccta ttttttctgc agaatcaatc attttttacg 114661 gaagaagagg aagcggtgct gaaaagaggc agaaatgcca agtcagggac aacacctaaa 114721 aatacagatg ttcagacgta ccgctacagt acagcatttg aagcgcttct gggctacctt 114781 tttctagaga aaaaagagga acgacttagt cagctcgtag ccgaagctat acaattcggg 114841 acgtcaggga ggaaaacaaa tgagtcagca acatgattac gtcataggga aaaatgcagt 114901 gatcgagacg ttaaaatctg atcggaagct gtataagctg tggatggcgg aaaacaccgt 114961 aaagggacaa gcacagcaag tgattgagct tgccaaaaag cagggaatca cgattcaata 115021 cgtcccgaga aaaaaactcg atcaaatggt gacaggacag catcagggcg tagtggcaca 115081 ggttgcagcg tatgaatatg cagaactgga cgatttatat aaagcagccg aagaaaaaaa 115141 tgaacagcct ttcttcctca ttctggacga gcttgaagac cctcataatc ttggttccat 115201 tatgaggaca gcagatgcgg tcggcgctca tggcatcgtc attccaaaac ggagagctgt 115261 cgggctgaca acaacagtgg caaaagcttc aacaggagca attgagcaca ttcctgtagc 115321 aagagtcacc aatttggcac ggacgttaga agagatgaaa gagcggggaa tctgggttgt 115381 cggaacggat gcgtccgcgc gtgaggattt ccgtaatatg gacggcaata tgcctttggc 115441 tctagtcatc ggaagtgaag gaaaagggat gggccgcctt gtgaaggaaa agtgcgattt 115501 tctcattaaa ctcccgatgg ccggaaaggt aacttcacta aatgcatctg tcgcggctgg 115561 tcttttgatg tatgaagtct accggaaacg aaaccctgtg ggagaataaa gacccatgga 115621 tatcctgtta gtagacgggt acaacatgat tggagcctgg ccgcagctga aggatttaaa 115681 agcgaacagt tttgaagagg cgagagacgt actgattcag aaaatggcgg aatatcaatc 115741 gtatacagga aacagggtta ttgttgtttt tgacgcgcat ctcgtaaaag ggcttgagaa 115801 aaaacagacc aaccatagag ttgaagtaat ttttacaaaa gaaaatgaga cggctgatga 115861 gcggatagaa aagctcgctc aggctttgaa taatattgcg actcaaattc acgttgcgac 115921 ctctgactat actgagcagt gggcgatttt cggacagggg gcattgcgga aatcggcccg 115981 ggagcttctg agagaggtag aaacgattga aaggcgaata gagagacggg taagaaaaat 116041 cacttccgaa aagccggcgg gtaaaattgc tttatcggaa gaggttttga aaacgtttga 116101 aaagtggagg cggggagact tagattaagt tgacgctttt ttgcccaata ctgtataata 116161 tttctatcta cgtgcgccgg ggggatcgga gtgaatctac agaacaacaa gggaaaattc 116221 aacaaagagc agttttgcca gttggaggac gagcaggtca ttgaaaaggt tcatgttggg 116281 gacagtgatg cgttagatta cttgattacg aagtaccgaa actttgttcg ggcaaaagca 116341 agatcctatt tcttaatagg ggcggacaga gaggatattg ttcaggaagg catgataggc 116401 ctctataagt ctattcgtga cttcaaagag gacaagctta cctcattcaa agcttttgca 116461 gaattatgta ttacccgcca aattattacc gcaataaaga cagctactcg ccagaaacac 116521 attcctttga attcctacgc ctcattagat aaaccgatct ttgatgaaga atcagaccga 116581 acgctgctgg atgtcatttc aggagcgaaa accttaaatc ctgaggaaat gatcattaat 116641 caggaagaat ttgatgatat tgaaatgaaa atgggagaac tattaagtga tttagagaga 116701 aaagtactcg tcttatatct cgacgggaga agttaccaag agatttctga tgaactgaac 116761 cgacatgtga aatcgatcga caatgccctt cagcgtgtga aacgcaagct ggagaagtac 116821 ttggaaattc gcgaaatcag tttgtaatag gaatttatgc tatattgaca gtatttttct 116881 gactatgata tgttactaaa gataagaact aatgtctatt tagaaaaagg tgtaatgaca 116941 tgagaaaaaa gattacgtta gcatgcaaga catgcggaaa ccgtaattat acgacaatga 117001 agagctctgc atcagcggct gagcgattag aagtaaagaa atactgcagt acttgcaatt 117061 cacatacagc tcatcttgaa acaaaatagt ttttgcgctt ttaaattgtg gaggtctttt 117121 acatgcgtat tatgaaattc tttaaagatg ttgggaaaga aatgaaaaag gtaagctggc 117181 ctaaaggaaa agagttaacg cgttatacca ttacggtaat ttcaacagtt atcttttttg 117241 ttatcttttt tgccctcctt gacacaggaa tttctcaatt aattcgttta atagttgaat 117301 aatgatcagc aatacgtgct ataatagatc ataatattac ttgccaaaac ccgttcagcg 117361 ggttttttat tgtggcttaa aatgaaagtt atcataggct tgccgcctat tttttgaagc 117421 gttatggtaa ttcactaaaa ccaaatgcgg ggagggaagg actggacagt cctgaataga 117481 atggaaaaga attggtatgt tgttcacacg tactctggtt atgagaataa agtaaaagcc 117541 aacttggaaa agcgtgttga atcaatgggg atgcaggata aaattttccg tgtagtcgta 117601 cccgaagaag aagaaacgga tatcaaaaac ggcaagaaaa aagtcgtgaa aaagaaagta 117661 ttccctggtt atgtgcttgt tgaaattgta atgacagacg actcttggta tgtcgtccgc 117721 aacacgccgg gcgttactgg attcgtagga tctgccgggt caggttcaaa accgacgccg 117781 cttcttccgg gggaagcaga aaccattctg aagagaatgg gcatggatga acgaaaaact 117841 gatattgact ttgaactgaa agagacagtg aaagtaatag acggaccttt tgctaacttt 117901 acaggatcaa ttgaagagat tgattatgat aaaagcaagg tcaaagtttt cgttaatatg 117961 tttggccgtg aaacgccggt tgagctggaa tttacccaaa tcgataaatt gtaatgtgaa 118021 aaaacttgaa attgctatat ataaatgata atatagcaaa ggtacgtctt ggacttatcc 118081 aaggcaacta gcatgatatt tcgtcattca tataaagaat gaaaccttga gtgggagggt 118141 ttaccctatt accacatcac ggacttaagg aggtgtgtct cgtggctaaa aaagtagtta 118201 aagttgtaaa attgcaaatt cctgctggaa aagctaaccc agcaccacca gttggacctg 118261 cacttggtca agccggtgtt aacatcatgg gattctgtaa ggagtttaac gctcgtacag 118321 ctgaccaagc tggtttaatc attcctgttg aaatttcggt ttacgaagac cgttcattta 118381 catttattac aaaaactcca cctgctgcag tattgcttaa aaaagcagct ggaattgagt 118441 ctggttctgg tgaaccaaac cgtaataaag tggcaaccgt taagcgcgat aaagtacgcg 118501 aaatcgctga aacgaaaatg cctgacttaa acgcagcaga cgttgaagcg gcaatgcgca 118561 tggttgaagg tactgcccgc agtatgggta ttgtaatcga ggattaattt gtttcttgtc 118621 gggttgcgag ttttaacaag ttcgcaaccc ttattcgtgg gaggttattc cgctataacc 118681 acataaggag gaaattttaa aatggctaaa aaaggtaaaa agtacgttga agctgctaag 118741 cttgtagacc gttctaaagc ttacgacgtc tctgaagcag tagctctcgt taaaaaaaca 118801 aacacagcta aattcgacgc tacagttgaa gtggctttcc gtttaggggt tgaccctcgt 118861 aaaaacgacc agcaaatccg tggagcagtt gtgcttccaa acggaactgg taaaactcag 118921 cgcgttctcg ttttcgcaaa aggcgaaaaa gcgaaagaag ctgaagctgc tggtgcagat 118981 ttcgtaggcg atactgacta catcaacaaa attcaacaag gctggttcga tttcgatgtt 119041 atcgtagcta cacctgacat gatgggtgaa gttggtaaaa tcggtcgtgt acttggacca 119101 aaaggtttaa tgccgaaccc taaaactggt acagttactt tcgaagttga aaaagctatc 119161 ggcgaaatca aagctggtaa agttgaatac cgcgttgata aagctggaaa cattcatgtt 119221 cctatcggta aagtttcttt cgaggatgaa aaacttgttg agaacttcac aacaatgtac 119281 gatacaatcc ttaaagctaa acctgctgca gctaaaggcg tttacgtgaa aaacgttgct 119341 gtaacttcta ctatgggacc tggtgtcaaa gtagactctt caacttttaa cgtaaaataa 119401 tattgacatg acatcaacat tctgatatta ttcaaaatgt tgtaaaatag aatatcattt 119461 ataccgtaga cagtaggggc ctaaccgctt aattatccta ccgaggtgta tattatcaca 119521 gctattacgt tacgtatgct tgtatataca gcctccatgt ctcatggagg ctttttatat 119581 ggaatccgtc gtctcagtcg tgatcaccta acggtataag tgttacacaa gaatctacag 119641 gaggtgtaac catgagcagc gcaattgaaa caaaaaaagt tgttgttgaa gaaattgctt 119701 ctaaactgaa agaaagtaaa tcaacgatca tcgttgacta tcgcggactt aacgtttctg 119761 aagtaactga acttcgtaaa cagcttcgcg aagctaacgt tgagttcaaa gtttacaaaa 119821 atacgatgac tcgccgtgcg gttgaacaag ctgagcttaa tggtttgaat gatttcttaa 119881 ctggaccgaa cgcgatcgca ttcagcactg aagatgttgt cgctccggct aaagttctta 119941 atgacttcgc taaaaatcac gaagctcttg aaatcaaagc tggcgttatc gaaggtaaag 120001 tttctactgt tgaagaagtg aaagctcttg ctgaacttcc atcacgcgaa ggcttgcttt 120061 ctatgttgct tagcgtactt caagctccag ttcgcaacct tgctcttgct gcaaaagctg 120121 tggcagaaca aaaggaagaa caaggcgctt aatctaatca gtttttcata aattaaaaca 120181 aaatggagga attacaaatg gctttaaata tcgaagaaat cattgcttcc gttaaagaag 120241 caactgtact tgaattgaac gacctagtaa aagcaatcga agaagaattt ggcgtaactg 120301 ctgctgctcc tgtagctgta gctggcggag ctgctgctgg cggagctgct gaagagcaaa 120361 gcgaattcga tcttatcctt gctggtgcag gatctcaaaa aatcaaagtt atcaaagttg 120421 tacgtgaaat cactggtctt ggcttgaaag aagctaaaga gcttgttgac aacactccaa 120481 aaccacttaa agaaggtatt gctaaagaag aagctgaaga gcttaaagct aaacttgaag 120541 aagttggcgc ttctgtagaa gttaagtaat cttcacttac ctgtagggga agctcgcttt 120601 tatgaggcga gctttttctt tgccattctt taagccatga aaaaaggagg ttctaataat 120661 gagtgagcac tattattcag aaaaaccttc agtaaaaagc aacaagcaaa cctggtcttt 120721 taggcttcgg aataaagatt tcacgtttac cagcgacagc ggggtttttt ctaaaaaaga 120781 agttgatttc ggctcccgcc tgctgattga ttcttttgaa gagcctgagg ttgagggcgg 120841 cattttagat gtaggctgcg gatacggccc gattggttta tcgctcgcca gcgactttaa 120901 agaccggacc atccacatga ttgacgttaa tgagagagcc gtagaactat caaatgaaaa 120961 tgcggaacag aacggaataa caaacgttaa gatttatcaa agcgatttgt tttcaaacgt 121021 tgattctgct caaacatttg cttctattct tacaaatccc ccaatccgag ccggaaaaaa 121081 agttgtccat gctatctttg agaaaagcgc tgaacactta aaagcttcag gtgaattgtg 121141 gatcgtcata cagaaaaagc aaggcgcgcc ttctgccatt gaaaagctcg aggaactgtt 121201 cgatgaagtt tccgtcgttc aaaaaaagaa aggctattat atcataaaag caaaaaaagt 121261 ttgactcggt attttaacta tgttaatatt gtaaaatgcc aatgtatata ttttgcttga 121321 tatgatgaat tgtcaatatc tatgtataaa ttatacaagt atggaaatgc taataaaatc 121381 ggtatttgtt tttggatgtg gttttcttaa ttagaaaccc ttttttcttt tgtcttgtaa 121441 aagtattttc tttctttgga agaaatgctt attacacata taatacgcat gatttgaggg 121501 gtgaatcagt tgacaggtca actagttcag tatggacgac accgccagcg cagaagctat 121561 gctcgcatta gcgaagtgtt agaattacca aatctcattg aaattcaaac ctcttcttat 121621 cagtggtttc ttgatgaggg tcttagagag atgtttcaag acatatcacc aattgaggat 121681 ttcactggta acctctctct tgagttcatt gattatagtt taggtgagcc taaatatcct 121741 gtagaggaat caaaagaacg tgatgtgact tactcagctc cgctaagagt gaaggttcgt 121801 ttaattaaca aagaaactgg agaggtaaaa gaccaagatg tcttcatggg tgatttccct 121861 attatgacag atacaggtac ttttatcatt aacggtgcgg aacgtgttat cgtttcccag 121921 cttgttcggt ctccaagtgt atatttcagt ggtaaagtag acaaaaacgg taaaaaaggt 121981 tttaccgcaa ctgtcattcc aaaccgtggc gcatggttag aatacgaaac tgatgcgaaa 122041 gatgttgttt atgtccgcat tgatcgcaca cgtaagttgc cggttacggt tcttttgcgt 122101 gctctcggct tcggctccga tcaagagatt cttgatctca taggagaaaa cgaatacctg 122161 cgaaatacgc ttgataaaga taacacagaa aacagcgaca aagcgttgct ggaaatttac 122221 gagcgtctcc gtcctggaga gccgcctaca gtagaaaatg cgaaaagctt gcttgattct 122281 cgtttctttg atccgaaacg atacgatctt gccaatgtag gacgctataa aattaataaa 122341 aaacttcata ttaagaatcg cctcttcaat cagagacttg ctgaaacgct tgttgatcct 122401 gaaacaggag aaatccttgc tgaaaaaggc cagattcttg atagaagaac gcttgataaa 122461 gtactgccat acttagaaaa cggaatcggt tttagaaagc tgtatccgaa tggcggcgtt 122521 gttgaagatg aagtgactct tcaatcaatt aaaatctttg ctccgactga tcaagaagga 122581 gaacaggtta tcaatgtaat cggcaatgct tacatcgaag aagagattaa aaacatcacg 122641 cctgctgata ttatttcttc aatcagctac ttcttcaacc tgctgcacgg agtaggcgac 122701 acagatgata tcgatcatct tggaaaccgc cgtttacgtt ctgtaggcga gcttctccag 122761 aaccaattcc gtatcggttt aagccgtatg gagcgtgtgg ttcgtgagag aatgtcaatt 122821 caagatacga atacaattac gcctcagcag ctgatcaata ttcgtcctgt tattgcgtcc 122881 attaaagagt tctttggaag ctcacagctt tctcaattca tggatcagac gaacccgctt 122941 gctgaattaa cgcacaagcg tcgtctgtca gcattaggac cgggcggatt gacacgtgag 123001 cgtgccggaa tggaagtgcg tgacgttcac tactcccact atggccgtat gtgtccgatt 123061 gaaacgcctg agggcccgaa catcggtttg atcaactcac tatcatctta tgcaaaagta 123121 aaccgttttg gctttattga aacgccatat cgccgcgttg accctgaaac agggaaggta 123181 acgggcagaa tcgattactt aactgctgat gaagaggata actatgttgt cgctcaagcg 123241 aatgctcgtc ttgatgacga aggcgccttt attgatgaca gcatcgtagc tcgtttccgc 123301 ggggagaaca ccgttgtttc cagaaatcgt gtagactaca tggatgtatc gcctaagcag 123361 gttgtatctg ctgcgacagc atgtatcccg ttcttagaaa acgatgactc caaccgtgcc 123421 ctcatgggag cgaacatgca gcgtcaggct gtgcctttga tgcagccgga agcgccattt 123481 gttggaactg gtatggaata cgtatcagga aaagactctg gtgccgctgt tatttgtaaa 123541 caccctggta tcgttgaacg cgtagaagcc aaaaacgttt gggttcgccg ttatgaagaa 123601 gtagacggtc aaaaagtaaa aggaaacctg gataaataca gcctgctgaa atttgtccgc 123661 tctaaccaag gtacgtgcta caaccagcgt ccgatcgtaa gtgtcggcga tgaagtggta 123721 aaaggagaaa tccttgctga cggtccttct atggagcttg gtgaacttgc acttggccgt 123781 aacgtaatgg tcggcttcat gacgtgggat ggctacaact atgaggatgc catcatcatg 123841 agtgaacgcc tagtgaagga tgatgtttat acatctatcc acattgaaga atacgaatca 123901 gaagcacgtg atacgaaact tggacctgaa gaaatcactc gcgatattcc aaacgtcggt 123961 gaagatgcgc ttcgcaatct tgatgaccgc ggaatcatcc gtattggggc agaagtaaaa 124021 gacggagatc ttcttgttgg taaagtaacg cctaaaggcg taactgaact gactgccgaa 124081 gaacgccttc ttcacgccat ctttggcgag aaagcccgcg aggttcgtga tacttctctt 124141 cgtgtgcctc atggcggcgg cggaattatc catgacgtta aagtcttcaa ccgtgaagac 124201 ggagacgaac ttcctccagg tgttaaccag ttagtacgcg tatatatcgt tcagaaacgt 124261 aagatttctg aaggggataa aatggccggt cgtcacggta acaaaggtgt tatctctaag 124321 attcttcctg aagaggatat gccttacctt cctgacggca caccaattga tatcatgctt 124381 aacccgctgg gcgtaccatc acgtatgaac atcgggcagg tattggaact tcacatgggt 124441 atggccgctc gttaccttgg cattcacatt gcatctcctg tatttgacgg agcgcgagaa 124501 gaggatgtct gggaaacact tgaagaagcc ggcatgtctc gtgacgccaa aacagtgctt 124561 tacgacggac gtactggaga gccgtttgat aaccgtgtat ctgtcggtat catgtacatg 124621 atcaaactgg ctcacatggt tgacgataaa cttcatgcac gctctacagg cccttactca 124681 cttgttacgc agcagcctct tggcggtaaa gcgcaatttg gcggacagcg ttttggtgag 124741 atggaggttt gggcacttga agcttacggt gcggcttaca ctcttcaaga aattctgact 124801 gttaagtctg atgacgtggt tggacgtgtg aaaacatacg aagccatcgt taaaggcgac 124861 aatgttcctg aaccaggtgt tccggaatca ttcaaagtat taatcaaaga acttcaaagc 124921 ttaggtatgg atgtcaaaat cctttctggt gatgaagaag aaatagaaat gagagattta 124981 gaagacgaag aagatgcgaa acaagctgac ggcctggcat tatcaggtga tgaagagccg 125041 gaagaaacag catctgcaga cgttgaacgc gatgtagtaa caaaagaata atctctagtt 125101 ataaaggcaa gtgacatcgg ttaatccgaa gataaaaagg gaggtaggcc ccttgctaga 125161 tgtgaacaat tttgagtata tgaacatcgg tcttgcttca ccagataaaa tccgttcatg 125221 gtcttttggt gaagtgaaaa agcctgaaac gataaactat cgtacgttaa aacctgaaaa 125281 ggacggtcta ttctgcgaac gcattttcgg accgactaag gactgggaat gtcattgcgg 125341 gaagtacaag cgagttcgtt ataaaggcgt agtttgtgac cgctgcggag tcgaagtaac 125401 acgggctaaa gtccgtcgtg agagaatggg gcacattgaa ctggctgccc cagtttccca 125461 catttggtat ttcaaaggta ttccaagccg tatgggtctt gtgctggata tgtcacctcg 125521 tgctttagaa gaagtcattt actttgcttc ttacgttgta actgatccgg cgaatacacc 125581 gcttgaaaag aaacagcttc tgtctgagaa agaataccgt gcttatcttg ataaatacgg 125641 taataaattc caagcatcta tgggtgctga agcaattcat aaacttcttc aagatatcga 125701 tcttgtaaaa gaagttgata tgttaaaaga agagctgaaa acttcacaag gacaacgccg 125761 tactcgtgcg atcaaacgtc ttgaagtttt agaagccttc cgtaactcag gaaacaagcc 125821 ttcttggatg atccttgatg tgcttcctgt tattcctccg gagcttagac cgatggttca 125881 gctagatggc ggacgttttg cgacttctga tttgaatgac ctttatcgtc gtgtcatcaa 125941 ccgtaacaat cgtttgaaac gccttttgga ccttggtgcg cctagcatca tcgttcaaaa 126001 cgaaaagcgt atgcttcaag aggctgtcga tgccctaatt gacaacggcc gccgcggacg 126061 ccctgtaaca ggtcctggaa acagaccgtt aaaatctctt tctcacatgc tgaaagggaa 126121 gcaaggccgt ttccgtcaaa accttcttgg taaacgtgtc gattactccg gacgttctgt 126181 aatcgttgtt ggtcctcatt tgaaaatgta ccaatgcgga ttaccgaagg aaatggcact 126241 tgaacttttc aaacctttcg ttatgaaaga acttgttgaa aaaggtcttg ctcacaacat 126301 taagagtgcg aaacgcaaaa ttgagcgcgt acagcctgaa gtttgggatg tactagaatc 126361 agttattaag gagcatccgg tactgctgaa ccgtgcccct acacttcaca gattaggtat 126421 ccaggcgttt gaaccaacgc ttgttgaagg acgcgcaatc cgtcttcacc cgctcgtatg 126481 tacagcttac aacgctgact ttgacggtga ccaaatggcg gttcacgtac cattatctgc 126541 tgaagcacaa gctgaagcac gcatcttgat gcttgctgct caaaacatct tgaaccctaa 126601 agatggtaaa ccggttgtaa caccgtctca ggatatggta ctaggtaact attacctgac 126661 acttgagcgt gccggtgctg tcggtgaagg tatggtcttc aagaatacag acgaagcgct 126721 tcttgcttat caaaacggat atgttcacct tcatacgaga gtagctgttg cagctaactc 126781 acttaagaat gtgacattta ccgaagaaca gcgctcaaaa ttgttaatta caactgtcgg 126841 taagcttgtc ttcaatgaaa ttcttccgga atcattccct tacatgaatg aaccaacgaa 126901 gagcaacatt gaagagaaaa cacctgaccg tttcttctta gaaaaaggtg ctgatgttaa 126961 agctgttatc gcacagcagc caatcaatgc gccgtttaaa aaaggcattc tgggtaaaat 127021 catcgcggaa atctttaaac gattccatat tacggaaacg tctaaaatgc ttgaccgcat 127081 gaaaaaccta ggtttcaaat attcaactaa agctggtatt acagttgggg tttctgacat 127141 cgtcgtactc gatgataaac aagaaattct tgaggaagcg caaagcaaag ttgacaacgt 127201 tatgaagcaa ttccgccgcg gtcttatcac tgaagaagaa cgctatgaga gagtcatctc 127261 tatctggagt gctgcaaaag acgttatcca aggcaaactg atgaaatcac ttgatgaact 127321 caacccgatc tacatgatga gtgactctgg tgcccgtggt aacgcatcta actttacgca 127381 gcttgccgga atgcgcggcc tgatggccaa cccggctgga cgtatcattg agttgccgat 127441 caaatcaagt ttccgtgaag gtctgacagt attggagtac tttatctcca cacacggtgc 127501 gcgtaaaggt cttgccgata ccgctcttaa aactgctgac tcaggttacc ttacacgccg 127561 tctcgttgac gttgctcagg atgttatcat ccgtgaaact gattgcggaa ctgaccgagg 127621 cattcttgct aagcctctta aagaaggaac tgaaacaatt gagcgcttag aagaacgctt 127681 aatcggacgt tttgcaagaa aacaagtgaa gcaccctgaa acaggtgaag tgcttgtgaa 127741 tgaaaacgaa ctgatcgatg aagataaagc actggagatt gtcgaagccg gcattgaaga 127801 agtgtggatc cgttctgcct tcacatgtaa tacgcctcat ggtgtatgta aacgatgcta 127861 tggccgaaat cttgcaactg gctccgatgt tgaagtcggt gaagctgtcg gaatcattgc 127921 tgcccaatca atcggtgagc ctggtacaca gttaacaatg cgtacattcc atacaggcgg 127981 ggttgccgga gacgatatca cacagggtct tccgcgtatc caagagcttt tcgaagcgcg 128041 taatccgaaa ggtcaggcaa caattacaga aatcgacggt acagtcgttg agatcaatga 128101 agttcgtgat aagcaacagg aaattgtggt tcaaggcgca gtggaaacac gttcttatac 128161 ggcaccttac aactcccgcc tgaaagtagc ggaaggagat aaaattactc gaggccaagt 128221 actgacagaa ggttcaatcg atccgaaaga acttcttaaa gtgactgacc tgacgactgt 128281 tcaagagtat cttctccatg aggttcaaaa ggtttaccgt atgcagggtg ttgaaatcgg 128341 tgataaacac gtagaagtaa tggttcgcca gatgcttcgc aaagtacgcg tgattgatgc 128401 cggtgacact gatgtgcttc caggtacatt gcttgatatt caccaattta ctgaagcgaa 128461 caaaaaggta ttgcttgaag gcaaccgacc agctacaggc cgtcctgtct tactcggtat 128521 tacaaaagca tctcttgaaa ctgattcatt cttatctgct gcttccttcc aggaaacaac 128581 acgtgtcctt acagatgcag cgatcaaagg taagcgtgac gagcttctcg gcttgaaaga 128641 gaatgttatc atcggtaagc ttgttccagc aggtacagga atgatgaaat accgtaaagt 128701 aaaaccagta tcaaatgttc agccgactga cgatatggtc ccggttgaat aactgattta 128761 actctgctga aagactgcaa aaacagtctt tcagcagata tatttatgaa aaagtcactc 128821 tatgagaaga acgaatctaa aaaatgtcat accttgttga cattcgtctc ctagaatgat 128881 aatataacca aggtgctcga aataaacctg ttactttgga ggatatgttt atgtcttatg 128941 ataaagtatc acaggccaaa tcaattatta ttggtacgaa gcaaacagtg aaagctctaa 129001 agcgaggttc agtaaaggaa gtagtcgttg caaaagacgc agatccgata ctcacgtcaa 129061 gtgttgtttc acttgctgaa gatcaaggta tctctgtctc aatggttgaa tccatgaaaa 129121 agctcggcaa agcctgcgga attgaggtag gagcagccgc tgttgccatt attttataac 129181 gtacttttgt ttttgcgtaa gattccatct tgtgtaaaga cattgttttt tgccttttga 129241 tgaaccacct gggtatgtgg gttataaaac gtaatgaagg gaggaaaaat tcatgcctac 129301 aattaatcag ctaattcgca aaggacgcgt gagtaaagta gaaaactcaa agtctcctgc 129361 acttaacaaa ggatacaaca gctttaaaaa agagcacact aacgtatctt ctccacaaaa 129421 acgcggggta tgtactcgtg ttggtacaat gacaccgaaa aaaccgaact cagcacttcg 129481 taaatatgct cgtgttcgtt tgactaacgg aatcgaggtt actgcttaca ttcctggtat 129541 cggtcacaac ctgcaagagc acagtgttgt acttatccgc ggcggacgtg taaaagactt 129601 accaggggta cgttaccaca tcgttcgtgg tgcgcttgat actgctggag ttgaaaaccg 129661 tgcacaaggc cgttctaaat acggtacgaa aaaacctaaa gcaaaataat atacgaaaat 129721 acgcataatt gatgaaggga ggatattcag atgccacgta aaggtcctgt agcaaaaaga 129781 gatgttttac ctgatccgat ttacaactct aagcttgtat ctcgtttaat caacaaaatg 129841 atgatcgatg gtaaaaaagg taagtctcaa acgatcctat acaagtcatt cgatatcatt 129901 aaagaacgta ctggcaatga tgcaatggag gttttcgaac aagcattgaa aaacatcatg 129961 cctgtacttg aagtaaaagc acgccgtgta ggtggtgcga actaccaagt tcctgtagaa 130021 gttcgtcctg aacgtcgtac gactcttgga cttcgctggt tagttaacta cgctcgtctt 130081 cgtggagaaa aaacgatgga agagcgttta gctaacgaaa tccttgacgc agctaacaac 130141 actggtgctg ctgttaagaa acgtgaagac actcataaga tggctgaagc aaacaaagca 130201 tttgctcact atcgctggta ggatttatag attaacaaaa cacaatttcc taataaggaa 130261 ggagaaatta cccaatggca agagagttct ccttagaaaa aactcgtaat atcggtatca 130321 tggctcacat cgatgccggt aaaacgacta ctacagaacg tatcttgttc tatactggtc 130381 gtatccacaa aattggtgaa actcatgaag gagcttcaca aatggactgg atggagcagg 130441 aacaagaacg tggtatcaca atcacttccg ctgcgactac tgcacagtgg aaaggatacc 130501 gcgtaaacat catcgatact ccaggacacg tagacttcac agttgaagtt gaacgttctc 130561 ttcgtgtact tgatggtgct gttgctgtac ttgacgcgca atcaggcgtt gagcctcaaa 130621 cagaaactgt ttggcgtcag gcaacaactt atggagtacc gcgtatcgtt tttgttaaca 130681 aaatggacaa aatcggtgca gacttccttt actctgtagg aactttaaga gaccgtcttc 130741 aagcaaacgc tcatgcaatt caattgccga tcggtgctga agataacttc gaaggtatca 130801 ttgaccttgt agaaaacgtt gcgtatttct acgaagatga cctcggaact cgttctgatg 130861 caaaagaaat ccctgaagag tacaaagagc aagctgaaga gcttcgcaac agccttattg 130921 aagctgtatg tgagcttgat gaagagctta tggataagta ccttgagggt gaagaaatca 130981 caattgacga gttaaaagca ggaattcgta aaggtacatt aaatgttgaa ttctaccctg 131041 ttcttgttgg ttctgccttc aaaaacaaag gtgttcaact agtacttgat gctgttcttg 131101 actaccttcc tgcaccaact gacgttgctg caatcaaagg tacacgtcct gatacaaatg 131161 aagagattga gcgtcattct tctgacgaag agccattctc tgcattagca tttaaagtta 131221 tgactgaccc ttacgttggt aagttgacgt tcttccgtgt gtactctgga acacttgatt 131281 ctggttcata cgtgaaaaac tctactaaag gcaaacgtga gcgtgttgga cgtattcttc 131341 aaatgcacgc taacagccgt gaagaaatct ctactgtata cgcaggggat atcgcagctg 131401 ctgtaggtct aaaagataca actactggag atactctatg tgatgagaag gatcttgtta 131461 tccttgagtc aatggaattc ccagaaccag ttatcgacgt tgctattgag cctaaatcaa 131521 aagctgacca agataaaatg ggtatcgctt tagcgaaact tgctgaagaa gatcctacat 131581 tccgtactca aacaaaccca gaaactggcc aaacgatcat ctctggtatg ggtgaacttc 131641 accttgatat cattgttgac cgtatgaaac gcgaatttaa agtagaagcc aatgttggtg 131701 ctcctcaagt tgcgtaccgt gaaacattcc gtaccggtgc aaaagttgaa ggtaaattcg 131761 tacgtcagtc tggtggacgc ggtcagttcg gacacgtttg gatcgaattc gaaccaaacg 131821 aagaaggcgc tggctttgaa tttgaaaatg cgattgtcgg tggggtcgtt cctcgtgaat 131881 acatcccagc tgttcaagca ggtctggaag atgcactcga aaatggtgta ctagcaggct 131941 tcccgcttat cgacattaaa gctaaacttt tcgacggttc ttaccatgat gttgactcaa 132001 acgaaatggc atttaaagtc gctgcttcta tggcattgaa aaatgcagtc agcaaatgta 132061 acccagttct tcttgaacca atcatgaaag tggaagtggt tattccagaa gaatatatgg 132121 gagatatcat gggtgatatc acttcacgtc gcggacgcgt agaaggtatg gaagcacgcg 132181 gtaacgctca agttgttcgt gctatggttc ctcttgctga aatgttcggt tacgctactg 132241 cacttcgttc taatacgcaa ggtcgcggta cgttcactat gcacatggat cactacgaag 132301 aagtgccgaa gagcgtcgca gaagaaatta tcaaaaaaaa taaaggcgaa taattgattt 132361 tgccgcttaa ctcaagtata actactattg taagatgagg aagtgaaagc tttctttcac 132421 ttcctatcac tctatacatt actaattaaa agctcttaag gaggatttta gaatggctaa 132481 agaaaaattc gaccgttcca aatcacatgc caatattggt acaattggac acgttgacca 132541 tggtaaaaca actttaactg ctgctatcac aacagtactt cataagaaat ctggtaaagg 132601 tacagctatg gcgtacgatc aaattgatgg tgctccagaa gaacgcgagc gcggtatcac 132661 aatctctact gcacacgttg agtacgaaac tgaaactcgt cactatgcac acgttgactg 132721 cccaggacac gctgactatg ttaaaaacat gatcactggt gctgcgcaaa tggacggagc 132781 tatccttgta gtatctgctg ctgatggccc aatgccacaa actcgtgagc acatccttct 132841 ttctaaaaac gttggtgtac catacatcgt tgtattctta aacaaatgcg acatggtaga 132901 cgacgaagag cttcttgaac tagttgaaat ggaagttcgc gatcttctta gcgaatacga 132961 cttccctggt gatgatgtac cagttgttaa aggttctgct cttaaagctc ttgaaggaga 133021 cgctgagtgg gaagctaaaa tcttcgaact tatggatgcg gttgatgagt acatcccaac 133081 tccagaacgc gacactgaaa aaccattcat gatgccagtt gaggacgtat tctcaatcac 133141 tggtcgtggt acagttgcta ctggccgtgt agaacgcgga caagttaaag tcggtgacga 133201 agttgaaatc atcggtcttc aagaagagaa caagaaaaca actgttacag gtgttgaaat 133261 gttccgtaag cttcttgatt acgctgaagc tggtgacaac attggtgccc ttcttcgcgg 133321 tgtatctcgt gaagaaatcc aacgtggtca agtacttgct aaaccaggta caatcactcc 133381 acacagcaaa ttcaaagctg aagtttacgt tctttctaaa gaagagggtg gacgtcatac 133441 tccattcttc tctaactacc gtcctcagtt ctacttccgt acaactgacg taactggtat 133501 catccatctt ccagaaggcg tagaaatggt tatgcctgga gataacactg aaatgaacgt 133561 tgaacttatt tctacaatcg ctatcgaaga aggaactcgt ttctctattc gtgaaggcgg 133621 acgtactgtt ggttcaggcg ttgtttctac aatcactgag taatagtatg gttttaaacg 133681 agacccctgt gggtctcgtt ttttgtttgc ttatcttttt cttgtataat aggatctatc 133741 atattcgagg ggttaatatt tatgattcct gaaaagaaat caatcgcaat catgaaagaa 133801 ctaagcattg gaaatacaaa gcaaatgctg atgattaatg gagttgacgt gaaaaatcca 133861 ttgctgcttt ttttacatgg cgggccggga acgccgcaaa tcggatatgt tagacattat 133921 caaaaagagc tggaacagta ttttacagta gttcattggg atcagagagg atcggggctt 133981 tcttattcta agcgaatttc gcatcactct atgacaataa atcacttcat taaagataca 134041 atccaagtca ctcaatggct tttagctcat ttttcaaaat caaaacttta cctagccggt 134101 cattcttggg gatcaatact ggcgcttcat gtgctgcagc agcgtcctga tttattttac 134161 acgtattatg gaatcagcca ggttgttaac ccgcaagatg aagaatcaac tgcttatcaa 134221 catattcgtg aaatttccga atcaaaaaaa gccagcatat tatctttcct tacacgtttc 134281 attggtgctc cgccttggaa gcaggatatc cagcacctta tctatcggtt ttgtgttgag 134341 ctaaccaggg gaggattcac tcaccgtcat cgtcaatctc tcgctgtatt atttcaaatg 134401 cttactggca atgagtatgg agtgcggaac atgcacagct tccttaatgg attgcgcttc 134461 agtaaaaaac atttaactga tgagttgtac cggtttaatg cttttacatc agttccttct 134521 attaaagtac cgtgtgtttt catttcaggg aaacatgact taattgttcc tgcagaaata 134581 tcgaaacagt attatcaaga acttgaggca cctgaaaagc gctggtttca atttgagaat 134641 tcagctcaca ccccgcatat tgaggagcca tcattattcg cgaacacatt aagtcggcat 134701 gcacgacacc atttatgata gatccttgat aaataagaaa aacccctgta taataaaaaa 134761 agtgtgcaaa tcatgcatat tttaaataag tcttgcaaca tgcgcctatt ttctgtataa 134821 tggtgtatgt tggtctttga ctgcgatgaa gtgagaggtt gctgacacac ccggccgctt 134881 tgccatggca aggtgttcag gtttttctca cggagaactg tctaacgtga tgtaggcgaa 134941 aaggagggaa aataatggca aaacaaaaaa ttcgtattcg tttgaaagca tatgatcata 135001 gaatccttga tcaatctgca gagaagattg ttgaaacggc aaaacgttct ggtgccagcg 135061 tatctggtcc gattccgttg ccaactgaaa aatcagttta cacaatcctt cgtgcggtgc 135121 acaaatacaa agattctcgt gagcaatttg aaatgcgtac acataaacgt ttaatcgaca 135181 ttgtgaaccc aacaccacaa actgttgatg ctcttatgcg attagactta ccatctggtg 135241 tcgatatcga aattaaactt taattctaaa atatagaatg atcttaatag gaggtgtgac 135301 gaatgaccaa aggaatctta ggaagaaaaa ttggtatgac gcaagtattc gctgagaatg 135361 gtgatcttat tccggtaact gttatcgagg ctgctccaaa cgttgttctt caaaagaaaa 135421 cagctgaaaa cgacggttac gaagcaatcc agcttggttt tgacgacaag cgtgaaaagc 135481 tttctaacaa acctgaaaaa gggcacgttg caaaagcgga aactgctcct aagcgcttcg 135541 ttaaagaatt acgcggagtg gaaatggatg cgtatgaagt tggtcaggaa gtcaaggttg 135601 aaattttctc tgctggagaa atcgtagatg taacaggagt atctaaaggt aaaggtttcc 135661 aaggtgcgat caagcgccac ggacaatctc gcggacctat gtctcacggt tcacgctacc 135721 accgtcgtcc tggttcaatg ggacctgtag atcctaaccg tgtattcaaa ggtaaattat 135781 tacctggacg tatgggcgga gagcaaatca ctgttcaaaa ccttgaaatc gtaaaagttg 135841 atgcagaacg caatcttctt ttgatcaaag gtaacgtacc tggtgcgaag aaatctttaa 135901 tcactgttaa aagtgctgtt aaatctaaat aattctctta ggaaaggagg aaattgatta 135961 tgccaaaagt agcattatac aaccaaaacg gttctactgc tggtgacatc gaattaaacg 136021 cttctgtatt tggtatcgaa ccaaatgaga gtgttgtatt cgacgctatt cttatgcaaa 136081 gagcttcctt acgtcaagga actcacaaag taaaaaatcg ttctgaagta cgcggcggag 136141 gtcgtaaacc atggcgtcaa aaaggtactg gacgtgcccg tcaaggttca atccgttcac 136201 cgcaatggcg cggaggtggt gtcgtattcg gcccaacacc acgcagctat tcttataaat 136261 tacctaaaaa agttcgccgc ttggcaatca aatcagtatt gtcttctaaa gtgatcgaca 136321 acaacatcat cgttcttgaa gatcttactc ttgatacggc taaaacaaaa gaaatggcag 136381 ctatccttaa aggattatct gttgagaaaa aagctttaat cgtaactgcg gatgcaaacg 136441 aagcagtagc attatctgct cgtaacattc ctggagttac tgttgttgaa gctaacggaa 136501 tcaacgtttt agacgttgtc aaccacgaga agcttctgat tacaaaagca gcggttgaaa 136561 aagtagagga ggtgcttgca taatgaaaga tcctcgtgat gttctaaagc gccccgtcat 136621 tactgaacgt tctgccgatt taatgactga aaaaaaatat acttttgaag ttgatgtaag 136681 agctaacaaa acagaagtga aagacgcggt tgaaagcatc tttggagtga aagttgacaa 136741 agtcaacatc atgaactaca aaggcaaatc aaaacgtgtt ggacgctaca ctggtatgac 136801 tagccgtcgc agaaaagcga tcgtaaaact tactgcagac agcaaagaaa tcgaaatttt 136861 tgaagcttaa ttatctgtaa aaagaaggag ggaaattcaa aatggcgatt aaaaagtata 136921 aaccgacctc taatggacgt cgtggcatga caacttcaga ttttgctgaa atcacgactg 136981 acaagccgga aaaatccttg cttgctcccc ttcacaaaaa aggcggacgt aacaaccaag 137041 gtaaattgac tgtacgtcac caaggtggcg gacataaacg ccaataccgt gttatcgact 137101 tcaaacgcga taaagatggt atacctggac gcgttgctac agttgaatac gatccaaacc 137161 gttcagctaa catcgctcta atcaactatg cagacggaga aaaacgttac attcttgctc 137221 ctaaaggaat tcaagtaggt actgaaatca tgtcaggtcc tgaagctgac attaaagtag 137281 gtaatgcact tccacttatc aacatccctg ttggtacagt tgtgcataac attgaattaa 137341 aacctggtaa aggcggacag cttgtacgtt cagctggtac atctgctcag gttcttggta 137401 aagaaggtaa atacgttctt gtacgtctta actctggtga agttcgcatg atcctttctg 137461 cttgccgtgc ttctatcggt caagtaggta acgaacagca cgaacttatc aacattggta 137521 aagctggacg ttctcgctgg aaaggcatcc gtcctacagt tcgtggttct gtaatgaacc 137581 ctaacgatca cccacacggt ggtggtgaag gacgtgcgcc aatcggacgt aaatcaccaa 137641 tgtctccatg gggcaaacca actcttggat tcaagactcg taagaaaaag aacaaatccg 137701 ataaatttat cgtacgtcgt cgtaaaaata aataacgggg ttgtctacgg ttcttttcgg 137761 accgtagtgc aatcacgaag ggaggttcca aaatggctcg cagcttaaaa aaaggaccat 137821 ttgtcgatgg acacttgatg actaaaatcg agaaattaaa tgaaacagac aagaaacaag 137881 tcgtaaaaac ttggtctcgt cgttctacta ttttcccaca gtttattggt cacacaatcg 137941 cagtctatga cggacgtaaa cacgtgcctg tattcatctc tgaagatatg gtagggcaca 138001 agttgggtga attcgctcca actcgtacgt acaaaggtca tgctagtgat gacaaaaaaa 138061 caagacgcta agagaggagg cttttaaatg caagctaaag ctgttgcaag aacagtccgt 138121 attgctcctc gtaaagcacg tctagtaatg gacctgattc gaggcaagca agtaggtgag 138181 gcagtatcaa tcttgaacct tacaccaaga gctgcttctc caattatcga gaaagtatta 138241 aaatccgcta ttgcaaatgc tgagcataac tatgaaatgg acgctaacaa cctggttatt 138301 tctcaagcat tcgttgacga aggccctacg ttaaaaagat tccgcccacg tgctatggga 138361 cgtgcgagcc aaatcaacaa acgtacgagc cacattacaa tcgttgtatc agaaaagaag 138421 gagggataag tagtgggtca aaaggtaaat ccagtcggtc ttcgtatcgg agtcattcgt 138481 gattgggaat ctaagtggta cgctggtaaa gattacgctg acttcctgca cgaagattta 138541 aaaattcgtg aatacattag caaacgcctt tctgacgctt ctgtttctaa agtagaaatt 138601 gagcgtgcag caaaccgcgt taacattacg atccacacag ctaagcctgg tatggttatc 138661 ggtaaaggcg gttctgaagt cgaagcactt cgcaaagccc ttaacagcct tactggcaag 138721 cgtgtacaca ttaacattct tgaaatcaaa agagcagatc ttgatgcaca gctagttgct 138781 gacaacatcg ctcgtcaatt agaaaaccgt gtttctttcc gccgtgcgca gaaacaacaa 138841 atccaacgta ctatgcgtgc tggagcacaa ggtgtgaaaa caatggtttc tggtcgtctt 138901 ggcggtgcag atatcgctcg ttctgaatac tacagtgaag gaactgttcc attgcacaca 138961 ttacgtgcgg acattgacta tgcaacatct gaagctgata ctacttacgg taagcttggt 139021 gtaaaagtct ggatctatcg tggagaggtt cttcctacta agaagaaaaa tgaggaagga 139081 ggaaaataat atgttattac caaaacgcgt taaatatcgc agagagcatc gcggaaaaat 139141 gcgtggccgt gcgaaaggcg gtactgaagt acatttcgga gaattcggta tccaagctct 139201 agaagcttct tggattacta accgtcaaat cgaagctgca cgtattgcga tgactcgtta 139261 catgaaacgt ggcggtaaag tttggatcaa aattttccct tctaaacctt acactgctaa 139321 accacttgag gtacgtatgg gatccggtaa aggggctcca gaaggttggg tagctgttgt 139381 aaaaccgggc aaagttttat ttgaaatttc tggtgtgtct gaagaggttg ctcgtgaagc 139441 gcttcgcctt gcatctcaca aattgccaat taaaacgaag ttcgtaaaac gtgaagaaat 139501 tggtggtgaa tcaaatgaaa gctaatgaaa ttcgtgacct taccactgct gaaattgaac 139561 aaaaagtaaa gtctcttaaa gaagaacttt tcaatcttcg ctttcaatta gcgacaggac 139621 aacttgaaaa tactgctcgc attcgtgaag tgcgcaaagc tatcgcgcgc atgaaaactg 139681 tgattcgtga aagagaaatt gctgctaata aataatcact gaggggaggt cgtgagcatg 139741 agcgaacgta accaacgcaa agtttaccaa ggccgtgttg tttctgacaa aatggataaa 139801 accattactg ttgttgttga gacatacaaa aaacatacac tttacggtaa acgcgtaaaa 139861 tactcaaaaa aattcaaagc acatgatgaa aataatcaag ctaaaatcgg tgacatcgtt 139921 aagatcatgg aaactcgtcc attgtctgca actaagcgtt tccgtctagt tgaagttgtc 139981 gaagaagctg ttattatcta ataaagttcg gaattctttt tccgaaggga ggtaacaaat 140041 aatgattcaa caagagactc gtttaaaagt agctgacaac tctggcgcac gtgaagtact 140101 tactattaaa gttcttggtg gttctggacg taaaacagct aacattggtg atgtaattgt 140161 ttgcacggtt aaacaagcaa caccaggagg cgttgtcaaa aaaggtgaag tcgtaaaagc 140221 tgttatcgtt cgcactaaaa gcggagcgcg cagaagtgac ggttcataca tcagcttcga 140281 tgagaatgca tgtgttatca tccgtgacga caagagccca cgcggaactc gtatcttcgg 140341 accagttgct cgtgaattgc gtgaaaacaa ctttatgaaa attgtttctc tagctccaga 140401 agttatctaa ttgaaataaa tgccttactc aaggaggtgc gatcaggatg catgtaaaaa 140461 aaggcgataa agttatggtt atctctggta aagataaagg caaacaagga acaatccttg 140521 ctgctttccc taaaaaggac cgcgttttag ttgaaggtgt taacatggta aagaaacact 140581 ctaaaccaac tcaagctaac cctcaaggcg gtatttctaa tcaagaggcg ccaattcatg 140641 tatcaaacgt tatgccgctc gatcctaaaa caggtgaagt gactcgcgta ggatacaaag 140701 tggaagatgg caaaaaagtt cgtgtagcaa aaaaatctgg gcaagttcta gataaatagt 140761 attaaaagga agggaggtct atctcatgaa ccgccttaaa gaaaagtaca ataaagaaat 140821 tgcacctgct ttaatgacta agttcaacta tgattcagtc atgcaagtgc ctaaaatcga 140881 aaaaatcgta atcaacatgg gtgttggtga cgctgttcaa aacgccaaag caatcgacag 140941 tgctgttgag gaattaacgt ttatcgcagg tcaaaaacct gtcgttactc gtgcgaagaa 141001 atcaattgct ggattccgtc ttcgtgaggg aatgcctatc ggtgcgaaag taactcttcg 141061 cggagagcgc atgtatgatt tccttgataa acttatttct gtatctttac cgcgtgtacg 141121 tgacttccgc ggggtttcta aaaaatcttt cgacggtcgc ggtaactaca cacttggtat 141181 caaagaacag ttaatcttcc ctgaaattga ctacgataaa gtaacaaagg ttcgcggaat 141241 ggacatcgtt atcgtaacaa ctgctaatac tgacgaagaa gctcgtgagc tattaactca 141301 agtaggtatg ccgttccaga aataatcaat gaaagggagg cgaaatcgtg gctaaaaagt 141361 ctatgattgc gaaacaacaa cgtacaccaa agtttaaagt acaagagtac acacgctgtg 141421 aacgctgcgg acgtccgcat tcagtcattc gtaaatttaa actttgccgt atttgtttcc 141481 gtgagcttgc atataaagga caaattcctg gcgtgaaaaa agccagctgg taatccccaa 141541 gaaagggaag gaggtaatta tataatggtt atgacagatc caattgcaga tatgctaact 141601 cgtattcgca atgcaaacat ggtacgtcat gagaagcttg aaattcctgc ttctaaattg 141661 aaaagagaaa ttgctgaaat tttaaagcgt gaaggtttca ttcgtgacgt tgagttcgta 141721 gaagacagca aacaaggtat tatccgcgtt ttcttgaaat acggacaaaa caacgagcgc 141781 gttatcactg gtcttaaaag aatcagcaag cctggtttgc gtgtttatgc taaatctaat 141841 gaagtacccc gcgtacttaa cggtcttgga atcgcgatta tttctacatc acaaggtgtt 141901 ttaacggaca aagaagcccg tgcaaaacaa gctggtggag aagttctagc atacgtttgg 141961 taagaagttt aacatgaatg gaggtgtttg gtatgtctcg tgtaggtaag aagctacttg 142021 agattccttc tgatgttaca gtaacgttaa atgataacaa cactgtagct gtgaaaggac 142081 caaaaggaga attaactcgt acgtttcacc ctgatatgga gattaaagta gaggacaatg 142141 tgcttacagt cgctcgtcct tctgatcaaa aagagcaccg tgccctgcat ggtacgactc 142201 gcagtctgct tggcaacatg gttgaaggtg tatctaaagg atttgaaaga ggtttggaat 142261 tagtcggtgt cggttaccgt gcttctaaat ccggaaataa acttgtttta aacgttggat 142321 actctcatcc tgttgagatc gttcctgaag aaggcatcga aatcgaagtt ccttctcaaa 142381 caaaagtagt tgtaaaaggt acagacaaag aacgcgtagg agctattgct gctaacatcc 142441 gcgctgtacg ttctccagag ccttacaaag gtaaaggaat ccgctacgaa ggtgaagttg 142501 ttcgccgtaa agaaggtaaa tctgctaagt aagatcgctt aaagtgaaga aaggagtgac 142561 ctagatgatt acgaaaacta gcaaaaatgc tgctcgtctt aaaagacacg ctcgtgttcg 142621 cgctaaactt tccggtactg ctgaaagacc gcgcctgaac gttttccgtt ctaacaagca 142681 catttacgct caaatcatcg atgatgtaaa tggtgtaaca cttgctagtg catctactct 142741 cgataaagac ttgaacgttg aaagcactgg agatacttct gctgctacta aagttggaga 142801 attagttgca aaacgcgctg ctgaaaaagg catttctgac gtagtatttg accgtggcgg 142861 atacttatac catggacgtg taaaagcttt ggctgatgcc gctcgtgaag ctggacttaa 142921 attttaataa aagaaggagg gacacatgat tatgcgtcgt attgacccaa gcaaattaga 142981 gttagaagaa cgcttagtta cggttaaccg cgtagcgaaa gttgttaaag gtggtcgtcg 143041 tttccgcttc gcagctctag tcgttgtcgg tgacaaaaac ggacacgtag gattcggtac 143101 tggtaaagca caagaagtac cagaagcgat tcgcaaagct gttgaagatg cgaaaaagaa 143161 tttgattgaa gtaccaatgg ttggaactac aattccacac gaaatcatcg gacgtttcgg 143221 tgcaggtaac atcttgttaa aacctgcttc tgaaggtact ggagttatcg ctggaggccc 143281 tgtacgtgcg gtacttgagc tagctggtgt agctgatatc ctttctaagt ctttaggttc 143341 taacacaccg atcaacatga ttcgtgcaac acttcaaggt ttaagtgaac ttaaacgtgc 143401 tgaagacgtt gcgaagcttc gtggaaaatc tgtagaagaa ctgttaggat aaggagggaa 143461 cattaatggc taaattagaa attaccctca aacgaagtgt aatcggtcgc ccggaagacc 143521 aacgcgttac tgtaagaaca cttggtttaa agaaaacaaa ccaaactgtt gttcatgaag 143581 acaacgctgc gatccgtggt atgattaata aagtatctca tttagtttct gttaaagaac 143641 aataaaaata tttgatcgga taaggaggtg tcctaatgaa acttcatgaa ttaaaacctt 143701 cagaaggttc acgcaaaacg cgtaatcgcg taggtcgtgg tattggttct ggcaacggta 143761 aaacagctgg taaaggtcac aaaggtcaaa acgctcgttc tggcggcggt gtacgccctg 143821 gattcgaggg gggacaaatg cctttattcc aacgtcttcc taaacgtggt ttcactaaca 143881 tcaaccgcaa ggaatacgct gtagtcaacc tagacaaatt gaacggtttt gcagaaggaa 143941 cggaagtcac tcctgaactt cttctagaga ctggtgttat tagcaaactt aatgcaggag 144001 taaagattct tggcaacggt aaattagaga aaaaattaac tgtaaaagcc aataaattct 144061 ctgcttctgc gaaagaagct gttgaagctg ctggcggtac agctgaggtg atctaacttg 144121 tttaaaacaa tctccaactt tatgcgtgtg agtgatatca ggaataaaat catattcact 144181 ttactcatgc ttatcgtctt tcgcataggt gcgtttattc ctgtgcctta cgttaacgct 144241 gaagcgttac aggcacagtc tcaaatgggt gtttttgatc tccttaatac atttggcggc 144301 ggtgcgcttt accaattttc cattttcgca atgggaatta ctccttatat cacggcttcg 144361 atcatcattc agctgcttca gatggatgtg gtaccgaagt ttaccgagtg gtctaagcaa 144421 ggtgaagttg gccgccgtaa attagctcag ttcacaaggt actttacgat tgtgcttggt 144481 ttcatccaag cgttaggtat gtcatatgga ttcaacaatc tggcaaacgg tatgctgatc 144541 gaaaaatccg gtgtatcgac atatcttatc attgctttag tgctcactgg cggaactgcc 144601 tttttaatgt ggcttgggga acaaattact tctcatggag taggcaacgg aatatcgatc 144661 attatcttcg cggggattgt gtctagtatt ccaaaaacaa ttgggcaaat atatgagact 144721 caatttgtcg gcagcaacga tcagttgttt attcatattg tgaaagtcgc acttcttgtg 144781 attgcgattt tagcagttat tgttggagtt attttcattc agcaagccgt acggaaaatt 144841 gcgattcaat atgctaaagg cacaggtcgt tcacctgctg gcggaggtca gtctacacac 144901 cttccattga aagtgaatcc tgcaggggtt attccggtaa tctttgcggt tgcgtttttg 144961 ataacgccgc ggacgatcgc gtcattcttt ggaacaaacg atgtgacaaa gtggattcaa 145021 aacaactttg ataatacgca tccggtgggt atggcgatat atgttgcgtt gattattgcc 145081 tttacgtact tttatgcttt tgtacaggta aaccctgaac aaatggctga taaccttaaa 145141 aaacagggtg gctatatccc gggggttcgt ccagggaaaa tgactcaaga tagaattacg 145201 agcattttgt atcgacttac gtttgtgggt tctatattct tagccgtgat ttccattctt 145261 cctatctttt tcattcaatt cgctggattg cctcaaagtg cacaaattgg cggaacatct 145321 ttgttaattg ttgtcggggt agccttggag acaatgaaac aactagaaag ccagttggtg 145381 aaacgaaact accgtggatt tatgaaaaac tagaggaaat ggatttatcc attccctctt 145441 aataaagaga ggacggggga aatccgaatg aacttagtct taatggggct tcctggtgcc 145501 ggtaaaggca cacagggcga acgaattgtt gaggattatg ggattcctca tatctcaaca 145561 ggagatatgt tccgtgctgc tatgaaagaa gaaacaccac tcggactcga agcaaaatct 145621 tatattgata agggagagct cgtacctgac gaagtcacaa tcggaattgt aaaagagaga 145681 cttggcaaag atgattgtga aagaggtttt cttctggacg gatttccgcg aacagtcgct 145741 caagccgaag ctcttgaaga aattcttgag gaatacggca agccgattga ttatgtcatt 145801 aacattgaag tcgacaaaga tgttctgatg gaacgtctga ctggacgcag aatttgcagt 145861 gtttgcggca caacctatca tttagtcttt aatccgccga aaacgccggg tatttgtgat 145921 aaagacggag gcgaactcta tcaacgggca gatgataatg aggaaacagt ctctaaacgg 145981 cttgaggtaa acatgaagca aactcagcct ttactcgatt tctattcaga gaaaggttat 146041 cttgcaaacg tgaatggcca gcaggacatt caagacgttt atgcagatgt gaaggatctt 146101 cttggaggat taaaaaaatg attatctgta aaaccccacg tgaacttggt atcatgcggg 146161 aagcagggcg aatcgtggct ttaactcatg aagagttaaa aaagcacatt aaaccaggaa 146221 tctcgacaaa agaattggat caaattgccg aacgttttat taagaagcag ggtgcaatcc 146281 catcttttaa ggggtataat gggtttcgcg ggagcatttg cgtatcagtt aatgaagaac 146341 tcgttcacgg catacctggc agcagggtgc tgaaggacgg tgacatcatc agtattgata 146401 tcggtgctaa attaaatggt tatcatggtg actctgcatg gacatatccg gtaggaaaca 146461 tcagcgatga tgacaaaaaa cttctggaag tgacagagga gtctttatat aaaggcttgc 146521 aggaagcaaa accaggtgaa cgtttgtcga atatttccca cgcaatacaa acgtatgtcg 146581 aaaatgagca gttttcagtt gttagggagt atgtcggaca tggtgttggt caagacttgc 146641 atgaggaccc gcaaattcct cattacggtc cgcccaacaa aggaccacgg cttaaacctg 146701 gcatggttct cgctattgaa cctatggtga acgctggcag ccgctacgtg aaaacattgg 146761 ctgataactg gacggttgta acggtagatg ggaaaaagtg tgctcatttt gaacatacga 146821 ttgcgattac ggaaacgggt tttgatatac tgacgagagt ctagatgatg aaaataattc 146881 cgaagacaga tgtttttcaa gcttgatagg gcagaaagct tgggtgaaca ttggcaagac 146941 cgaattcatc ttgcttcttg tcgttggaat tttaaccatc atcaatgtac taacagcaga 147001 cggagaaaag cgtacatttc attctcctaa gaaaaagaat atcaatcatt taacccttta 147061 tgattgcgta tctccggaag ttcagaacag tataaacgaa acagggcgtg tgacaaactt 147121 cttttgaaat ttgtcagaaa gcaagttact gatttgaaga agggagaaca cttgaatggc 147181 gaaagacgat gtaattgaag tggaaggtac tatagtcgaa acactgccaa acgcgatgtt 147241 caaagttgaa cttgaaaatg gccacactgt tttggctcat gtatctggta aaatccgcat 147301 gcacttcatt cgcattttac ctggagacaa agttacggta gaattatctc catatgactt 147361 aactcgtggc aggattacgt accgttacaa ataaagcact ccggaaactg aaggaggttg 147421 gaaacacatg aaagtgagac catcagttaa accaatctgc gaaaaatgta aagttattcg 147481 cagaaaagga aaagtaatgg tgatctgtga aaatccaaag cataaacaaa aacaaggata 147541 atttataagg aggtgcccag agaatggctc gtattgctgg tgtagatatc ccacgtgaca 147601 aacgtgttgt tatttcttta acatacatct tcggaattgg ccgcacaacg gctcagcaag 147661 ttttaaaaga agctggagtt tcagaagata ctcgtgtgcg cgatcttact gaagaagaac 147721 ttggtaaaat ccgtgatatt attgacaaac tgaaagtaga aggtgacctt cgccgtgaag 147781 tttctcttaa tatcaaacgt ctgatcgaaa tcggaagcta ccgcggaatc cgtcatcgca 147841 gaggattacc tgttcgcgga caaaactcta aaaacaacgc gcgtactcgt aaaggtccgc 147901 gtcgtactgt agctaacaag aaaaaataag taagggaggt tcttaaacaa tggctgctgc 147961 tcgtaaatct aacacgcgta aacgtcgcgt gaaaaagaat attgagtctg gaattgctca 148021 tattcgttca actttcaata acacgatcgt tacgatcact gacactcatg gtaatgctat 148081 ttcttggtct agtgccggag ctttaggatt cagaggttct cgtaaatcta ctccttttgc 148141 tgcgcaaatg gctgcagaaa cagctgctaa aggttcaatc gaacatggtc ttaaaactct 148201 agaggttact gttaaaggac ctggttcagg ccgtgaagct gcaatccgtg cacttcaagc 148261 tgctggacta gaagtcactg ctatcagaga cgtaactcct gttcctcata acggatgccg 148321 tccaccaaaa cgtcgccgcg tgtaatttgt ttgtatagat tttgtgtccc tgtcaataat 148381 gggttatgat acagttattt atgaaacgaa tgcaccgact cgttgcctga gcacatacgg 148441 gactaaacaa tggggaattt cggatggaat ctcatatgat tctattcgag gtttcgacgt 148501 tttgaaggag ggttttaagt aatgatcgag attgaaaaac caaaaatcga aacggttgaa 148561 atcagcgacg atgccaaatt tggtaagttt gtcgtagagc cacttgagcg tggatatggt 148621 acaactctgg gtaactcctt acgtcgtatc ctcttatcct cactccctgg tgccgctgta 148681 acatcaatcc agatagatgg tgtactgcac gaattctcga caattgaagg cgttgtggaa 148741 gatgttacaa cgattatctt acacattaaa aagcttgcat tgaaaatcta ctctgatgaa 148801 gagaagacgc tagaaattga tgtacagggt gaaggaactg taacggcagc tgatattaca 148861 cacgatagtg atgtagagat cttaaatcct gatcttcata tcgcgactct tggtgagaat 148921 gcgagtttcc gagttcgcct tactgctcaa agaggacgtg ggtatacgcc tgctgacgca 148981 aacaagagag acgatcagcc aatcggcgtg attccgatcg attctatcta tacgccagtt 149041 tctcgtgtat cttatcaggt agagaacact cgtgtaggcc aagttgcaaa ctatgataaa 149101 cttacacttg atgtttggac tgatggaagc actggaccga aagaagcaat tgcgcttggt 149161 tcaaagattt taactgaaca ccttaatata ttcgttggtt taactgacga agctcaacat 149221 gctgaaatca tggttgaaaa agaagaagat caaaaagaga aagttcttga aatgacaatt 149281 gaagaattgg atctttctgt tcgttcttac aactgcttaa agcgtgcggg tattaacacg 149341 gttcaagagc ttgcgaacaa gacggaagaa gatatgatga aagttcgaaa tctaggacgc 149401 aaatcacttg aagaagtgaa agcgaaacta gaagaacttg gactcggact tcgcaaagac 149461 gattgactag tttcccttgt gaactaggat tttcgtgtgt ttattattca gaaacagcat 149521 tccaataaag gaggggacat cacatgtcat acagaaaact aggacgtacg agtgcacagc 149581 gtaaagctat gcttcgtgat cttacaactg atttgatcat caacgaaaga atcgaaacaa 149641 ctgaaacacg tgcgaaagaa cttcgctctg tagttgaaaa aatgatcacg cttggcaaac 149701 gcggtgatct tcacgctcgc cgtcaagctg ctgcatacat ccgcaacgag gttgcaaacg 149761 aagaaaataa tcaagatgca cttcaaaaat tattctctga cattgcaact cgttacgagg 149821 agcgccaagg tggatacaca cgtattatga agcttggtcc tcgccgtggt gacggagcac 149881 caatggcaat tatcgaattg gtttaatcac atatttttgt gtatctaaag aagggcggga 149941 cagtttctaa ctggatctat gccctttttt tagatactgc aacttttaat agagagaaaa 150001 gcagagcatt agctgagagg aggccggttt tccatgaatc aaaatcagtt gatatcggta 150061 gaggatatcg tatttcgata tcggaaggac gcagaaagac gagcactaga cggcgtctcc 150121 ctgcaggtgt atgagggtga atggcttgca atcgtaggtc ataacggttc agggaaatca 150181 acactggccc gggcattgaa tggtttaatt cttcctgaat caggcgacat tgaggttgcc 150241 gggattcaat tgacagagga atctgtttgg gaagtgcgta agaagatagg tatggtcttt 150301 caaaatccgg ataaccaatt tgtcggaacg actgttcgcg atgatgtggc ttttggttta 150361 gaaaacaatg gtgtaccgcg ggaagaaatg attgagagag tagactgggc agtaaaacag 150421 gtgaatatgc aagattttct cgatcaagag ccgcaccatc tctccggagg ccaaaagcag 150481 agagttgcga ttgcgggggt tattgccgca cgtcctgata ttattatctt agatgaagca 150541 acatccatgc ttgatccgat cgggcgagaa gaagtgcttg aaacggtaag acatttaaaa 150601 gagcagggca tggcgactgt catatccatt acacatgacc tgaatgaggc agcaaaagca 150661 gacaggatca ttgtcatgaa tggcggtaaa aaatatgctg aagggccgcc tgaagagatt 150721 tttaaattga ataaagaact tgttcgaatt gggcttgatt tacccttctc attccagctt 150781 agccagcttt taagagaaaa tggactggct ttggaagaaa accatttgac tcaggaaggg 150841 ctggtgaaag agctgtggac attacaatca aagatgtaga gcatcgctat cagatgaaga 150901 ccccgtttga gcgcctagca ctgtatgata tcaatgcatc gattaaagaa ggaagctacg 150961 tagccgttat cgggcataca ggctctggca agtccactct tctacagcac ctaaatggtc 151021 tcctgaagcc gacgaaggga cagatatcac taggcagcac tgtcattcag gcagggaaaa 151081 agaataaaga tctgaaaaaa cttcgtaaaa aagtcggaat cgttttccaa tttcctgagc 151141 atcaattatt cgaagaaaca gttcttaaag atatttcatt cggaccgatg aactttggtg 151201 ttaaaaaaga agatgctgaa caaaaagcga gagagatgct gcagcttgta ggtttatcag 151261 aagagctttt ggacaggtca ccctttgaat taagcggggg acaaatgcgc agagttgcaa 151321 ttgccggcgt acttgcaatg gaccctgaag tgcttgttct ggatgaaccg actgcaggat 151381 tggacccaag agggcgaaaa gagattatgg acatgtttta tgagcttcat caacgtggga 151441 acttgacgac gatccttgtg acacacagca tggaggatgc agctgcatac gctgatgaaa 151501 tgattgttat gcataaagga acgatacaag catcaggcag tccgcgtgat ctgtttttaa 151561 agggtgaaga gatggccggc tgggggctgg atcttcctga aacaataaaa ttccaaagac 151621 accttgaagc tgcactgggt gtgagattta atgagcctat gctcacaatc gaagatgccg 151681 ctgccgaaat ccgtgctctt tttcagggag agaagacttt atgatggaca gcatgattat 151741 cggcaagtat gtaccgggga cttcacttgt gcaccggctt gaccccagaa caaaactgat 151801 cacgatcttt ttatttgtct gcattgtatt cttagccaat aatgttcaga catatgcgtt 151861 gcttggttta tttacaattg gcgtcgtttc tttaacaaga gttcctttct cttttttaat 151921 gaaagggctg aagccaatca tctggattgt cctttttacg ttccttcttc acattcttat 151981 gacacatgaa ggaccgatta tctttcaaat aggttttttc aaagtctatg agggcggtct 152041 ggttcagggg atattcattt ctcttagatt cgtctatttg attttaatca caaccttatt 152101 aacgcttacg actacaccga ttgagattac cgatggaatg gagcagctgc tgaacccatt 152161 gaaaaaatta aagcttcctg ttcatgagct ggctcttatg atgtcaattt ctttacggtt 152221 tattccgaca ctgatggagg agacagataa gatcatgaag gctcagatgg cgcgaggcgt 152281 tgattttaca agcgggcctg tcaaagaaag agtgaaggct attgtcccgc ttcttgtccc 152341 gctcttcgtc agcgcattta aacgcgccga agagcttgcg gtggcaatgg aagcaagagg 152401 ctatcaaggc ggagaaggac gtacgaaata tagaaagctt gtatggacag gaaaagacac 152461 ttctgtcatt gtcagcttaa ttgtattagc tgctttgtta tttttcttaa gggcttagag 152521 gtgctgtatg agactgaaat gcacgatttc ttatgacgga catttgttta acggttatca 152581 ggttcagccg ggcaaaagaa cggttcagga tgaactggag aaggctttgg ctgtcctgca 152641 taagtcaaaa gacagaattc cggtcgtttc gtctggaaga acagacagcg gggttcacgc 152701 agccggacag gtgattcatt ttgacactcc gctgtctatc ccggctgaga gatggccata 152761 tgccttaaat gcactgcttc cggacgatat cgcagtcaaa caggcagaaa ttgcggatga 152821 tgggttccat gcacgattta gcgcagtcaa aaaagaatat cgctactttg tatacacgga 152881 gaaacacccg gacgtattta aacggcatta cgcttaccat ttttcatatc gccttaatgt 152941 gcaggacatg agagaagcgg caaagcatct tatagggaca catgatttta cgagcttttg 153001 cgcggctaaa acagaagtgc aggacaaggt aagaacgata tacgaacttg attggactga 153061 gacggctgac ggcctgcaaa tgcggatcac aggcagcggt ttcttatata atatggtcag 153121 aattattgcg ggtactttgc ttgatgcagg tattggaaaa atttctcccg atgaggtgaa 153181 atccatgctg gaagcgaagg atcgcgaagc ggcagggcgc acagcgccgg ggcacgggct 153241 atatttatgg aacgtttact atgacaacta aaccaggtgt ataatatttt cttgacagag 153301 tctgcataaa gttataagat atcatatggt atgtatttca accccacgat aagccccgga 153361 acttattgtg ttgtgaaata gaacgtaatc gaagtttatt gaaaatgaca gatcatttag 153421 gagggaaatt caatgcgtac aacacctatg gctaacgcaa gtactattga acgcaagtgg 153481 ttagttgttg atgctgctgg caagacttta ggtcgtcttt cttcagaagt tgcagctatc 153541 cttcgcggaa aacacaaacc aacttacaca ccacacgttg atactggaga tcatgtgatc 153601 atcatcaacg ctgaaaaaat cgagttaact ggtaaaaagt taactgacaa aatctactac 153661 cgtcacactc aacatccagg cggattaaaa tcaagaactg ctcttgaaat gcgtacaaac 153721 taccctgaga aaatgcttga gcttgctatc aaaggcatgc ttccaaaagg ttctctaggt 153781 cgtcaaatgt tcaaaaaatt gaacgtatac cgtggttctg agcatccaca cgaagcacaa 153841 aaacctgaag tttacgaact tcgcggttaa ttaaaaagga ggttaccaat ttggcacagg 153901 ttcaatatta cggtactggc cgtcgtaaaa gctctgtagc gcgtgtgcgt ttagttccag 153961 gagaaggccg tatcgtcgtt aataatcgtg aaatcagcga acatatccca tctgcagctt 154021 taatcgaaga tatcaaacaa ccattaactt tgactgaaac agctggcact tatgatgttt 154081 tagtaaacgt acatggaggc ggcctatctg gtcaagctgg agcaatccgt cacggtatcg 154141 ctcgtgcttt gcttgaagca gatccagaat accgtacaac tcttaaacgt gcaggtcttc 154201 tgactcgtga cgctcgtatg aaagaacgta aaaaatacgg tcttaaaggc gctcgtcgtg 154261 cacctcagtt ctcaaaacgt taattttacg ttttcaaaaa gctctcgacc ttgggttggg 154321 agcttttttc tttcaataaa acgtggcagt cccgcataaa aataacaact gaatggacgc 154381 ttgacggggt taagcaaatt gtttgtttat aaacggtctc tttgtaataa tcatggtaga 154441 tttcattctt attcaattgg aagttcggtc aatgtttatt atcgttatgt gatcagccca 154501 gctccatcta accactgtat ctcatccgtt aaagttcact gctgattctt aacccggaga 154561 aacaatagct ctcattgcta atggctttat gtaacgaagt aaaagtaaat ctgatgatat 154621 aaatcacata tctcctttgt gatttttttg cgtttttatg aacttttttc taaatatgca 154681 aagggaaagc gatatcaatc tagaaatatt tgttatactc tatacattaa agtaaggaga 154741 agattcatga atgcgttagt agctcataat agcaaagcct gggataaaaa agtagaaaca 154801 ggcaatgaat ggactgttgc tgttgaacag caggttatcg aacaagcaaa aaaaggcaat 154861 tgggatataa gggtaacacc aatgaaagat gtaccgaagg attggtttcc gcctatcaaa 154921 ggtctgaaag tactctgttt agcatcaggc ggcggccagc agggtccagt tttggcagcc 154981 gcaggcgcgg atgtcactgt attagataac tcagaaaaac agctgaatca ggatagaatg 155041 attgctgagc gagatggtct gacgatacac actgtcaaag gaagcatgga cgatttaagt 155101 gtatttaatg atgaatcatt tgatgtcatt gtacatcctg ttgccaatgt ttttgttgag 155161 aatgtcctcc cggtatggaa ggaagcgtac cgtgtgttga aaaggaacgg cattctaatc 155221 tcgggttttg tcaatcctgt tgtatttctg tttgatacag aattagaaca gcaaggtgtt 155281 ttaaaagtaa aacactctat tccatacgct gacccagaag atcttccgaa acataaagtg 155341 aaaaaactga tcgaaaataa tgaggctctg gaattcggcc attccttaga agaccaaatc 155401 aaaggccaaa ttgatgccgg ttttatcgtt actggttttt atgaagataa aggcggtttt 155461 gtattagacc aatatatcca tacatattct gcaacaagaa gcgtgaaagt atgaaaagca 155521 gcgacctgtt agaggggctg cttttttcat aaccaattac agaacatttg ttcctcaccc 155581 tgcagaaagc tgatttttta tcaatgttac accttcattt gggcgaattt ccaaccgaat 155641 tcgggcattg tttcatcatc caaacctcaa aataatcggt aaaaggagag tgaatttata 155701 tggcagaagt actgtctttt atggatgtga aacgccaaaa ggattttgaa ttagaaaaga 155761 acttgctcaa agaactctct ctgagacaaa ttatccagtc tgttaaggat tgtttggaac 155821 cattatttcc atttttacat gatgaacgag atattattac cgaaggctgt attgattttg 155881 cgattgaagc ttatttgtta ggcgggcgtt ttgggatatt cggctattac ggagaatcaa 155941 tgcagagtat cagtgcccgc tctgcaagag aagaagaaga gctgcgtatg gagttttttg 156001 attatctcta taattggata cacgagcaat acgcaacatt tgataaaaac actgtttatg 156061 aagcggcacg caagttcatt aaagattggt ggacagcagg gtttgttcaa agagaaaaac 156121 agtgtaagct tcgcatgcgg taatcatatt tcccgaccct gtcccatagt tatgtaataa 156181 cggacaagcg ggaggggaag ggatgaggaa aaagcttaaa tggctcagtt ttttgctagg 156241 cttcatcata ttactatttc tgttcaagta tcagttcagc aataacgact cttggaagcc 156301 gtggagcctg cccttgagcg gtaaaatcat ttatctagat ccaggtcatg gcgggcctga 156361 cggcggagca gtcggcggaa agctgttaga gaaggatgtt accctggaag tggcctttag 156421 agtcagggat tatcttcaag aacaaggagc gcttgttatc atgaccagag aaagtgatac 156481 tgatctcgct ccagaaggaa caaaaggcta tagccgacga aaagctgagg atctaagaca 156541 acgagtcaaa ttaataaacc attcagaggc ggagctctat atcagcattc atcttaatgc 156601 gattccgtca caaaaatgga gcggagccca aagcttttat tacgggaaat atgcggaaaa 156661 tgagaaagtc gcaaaataca ttcaggatga gctgagaaga aatctggaaa acacaacccg 156721 gaaagcaaag cggattcatg gtatctactt aatgcaaaac gtcaccaaac cgggggcgct 156781 tatagaagtc ggatttttat ccaatccaag tgaagcaacg ttgctcggta aaccgaaata 156841 tcaagacaag gtggcatctt ccatatataa aggcattttg cgatatttca cagaaaaagg 156901 agaccctccg gagtaatgga gggttttctt gtggttctaa gcataagaca cccgccattt 156961 atgtatgata taataataat tgtaaacgaa tacacaaaag ggtgaggttc gatgataaga 157021 gaagatgaag taagaaaact agtcggagaa atgcgcgaac cttttcttca aagacctctg 157081 ggagaattgg atgccgttaa ggaaattaaa ataaagcctg aaaaacggca tatcagtgta 157141 aaagtcgctc ttgcaaaaac aggaactgca gaacaaatgc agattcagca agagatcgta 157201 aacgtattaa aaggggcagg agctgagaca gtcggccttc gatttgaaga gctgcctgaa 157261 gaaacggttg ctaaattccg ggcgccgtca gctgagaaaa aaacattatt aaatatggat 157321 aacccgccag tctttcttgc tgtagcaagt ggaaaaggcg gcgtaggcaa gtcaactgtg 157381 tcagtaaacc tagctatttc tctggctcgt ctagggaaaa aggttggttt aattgatgcg 157441 gatatttatg ggttcagtgt gccggacatg atgggtatca ctgtgcgtcc aacaattgaa 157501 ggagagaaac ttcttcctgt tgaacgcttt ggagtaaagg tcatgtcaat gggctttttc 157561 gtagaagaaa atgccccggt cgtatggaga gggccgatgc tcggcaaaat gctgaataat 157621 tttttccatg aagtagagtg gggagaagta gactatatcg ttcttgatct tccgcctggt 157681 acaggggacg ttgctctcga tgtacataca atgcttccga gctgcaaaga aattatcgta 157741 tctacgccac atccgacagc tgcttttgtc gcggccagag cgggctctat ggcgattaaa 157801 accgatcatg aggtcgtggg tgtcatagag aacatggctt attatgaaag tgcaaagaca 157861 ggggaaagag aatatgtgtt tggaaaaggc ggaggagata aactggctga ggaactaaac 157921 gtgcctttgc tcggcagaat cccattgaaa cagcccgatt gggataagga ccaatttgct 157981 ccgtctgttt atgacgaaaa tcatccaatc ggagaaatat atcaggacat cgcaaaaaaa 158041 atagatgcaa aaatgtcagt gcaggtataa aaggtgaacc gggattccag atcccggctt 158101 tccctttatt cactttcttt tgctgtgtct tttgctgctt ttttcagctc atcttcgaac 158161 tgctttttgt aaagcggact agaaagtgtt tcgttaataa cctcttctaa ataactgcgg 158221 aattcttggc tttttgccag ctggctgtac tttttatcca tgccgggatc ctgcataacg 158281 ctcatcagca tcttctggta atctggatcc ttcatcagct ttttaatcac tttttcatgc 158341 tctgtctgaa gagttttggc aaagccctca gcaaaatcag tgtcttcaaa gatgtttttc 158401 caaaattctt cacctttttt agatgtgagt gttttttcta ttgttccttt aattgcatct 158461 tggtcaatca ccagcgcttc attcatggca tcatcattta ataattcctt aatagctttc 158521 tttccatcat cagtttttaa tatatcaaca accatttttt tggtctgatc atagtccata 158581 tccgctgctt ggtcttttgg agcgcaagct gttacagata ataacaaaaa acagctcatc 158641 aatagcgttt tggcttttga catgcttaag ctcctttcac atacttgtct tacctttaat 158701 atgattcatc tgtttggaat tatacataac aaaatatcgc tgttcgcgat ttttgagggg 158761 atgaataaag aaatgaaaag ccgtggttta gttcgttttt tcttttctat tttagctgtc 158821 ggggcgctta tcacgagtat tgtgggtttt gctttaaagt ggggagaata tagagggctg 158881 tttctaacat ttgaagcggg acagattttc tctgttttat tttggtttat cggtgtaggc 158941 atgattttca gtgtgatcag ccaaatgggt tttttcgtgt ttttaacagt tcatcggttt 159001 gcgcttgaga tattaaggtc ctcctctttg tggaatttgc tgcagttgtt tttcatcctg 159061 tttgttgctt ttgatttaat gtacgtgcgt tttttatttt ttggagagag cggagaatcg 159121 ctggctggct atgcgtggtt accggtgttt ttattgatct ttggagtgat tacagcttat 159181 ataaagcaaa agcagtcctc taagaaaaca tttgtgtcat cgttattttt gatggttgtg 159241 attaccgcat tagaatggtt ccctgcatta agagtaaatg atgaggactg gctttattta 159301 atgctttttc cgttaatggc atgtaatgcc ttccaattgc tgatgctgcc gaagtttgca 159361 gcaaagtaat tactttacct ctgcggattt ggcatcagaa tttgcgatga gatcacccac 159421 ggttacattt tttaatcctt tttctttcag ctgatggatg atatcaggca atgcttcttc 159481 tgtttgtttt gcagaatcgg aggcatgtaa aagaataatg tctccaccgg aaacttgctt 159541 ggtcacattg tcgatgattt tttcaactcc gggatttgtc cagtcttgag agttcacact 159601 gtaatgaacg actgtataat tgtattgctt tgcgaccttt agaacattct tattgaattg 159661 gccggtaggg ggtcttaata gctgtatgtc tttgacccct aacttttcaa aggctgtttg 159721 cgcacggttc atgtcctttt ttatttcgct gctctctaaa ttggcatagt ttttataagc 159781 gtagcccatg ctcccgattt gatggccgtc ctttacgata cgggccactg tgtcgggatg 159841 gcgttctgcc caagaagcgg acaggaaaaa cgttgcgttt ttaatcccgt ttgctttcag 159901 agtattaagt atcggttctg ctctctcatc accccagctg atatcgaaag taagtgaaat 159961 atctttagag tctgtttctc ctttataaat ggctttaggt ccggtgtcag ttgaaaacac 160021 gggaagcggg acagctcttt ggatataaaa aaagctggca gctgcaaatg cggcgataag 160081 tataataatt aattgtttta cccgtttaat gtgccacaca tagaagtgat tcactgatga 160141 tgcctcctta tcttgtccat cattcttgtt ttacatctta tgagcatgga caattgaata 160201 taaccgataa aatgtctctt cacatacagc ctaaattggg tgttgacctt ttgataatat 160261 ccgtgatata ttattattcg tcgctgataa acagctgaca tcaactaaaa gcttcattaa 160321 atactttgaa aaaagttgtt gacttaaaag aagctaaatg ttatagtaat aaagctgctt 160381 cgttaagcgg cagtaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca 160441 tttttataaa tcgcacagcg atgtgcgtag tcagtcaaac tactttatcg gagagtttga 160501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cggacagatg 160561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 160621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 160681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 160741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 160801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 160861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 160921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 160981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 161041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 161101 gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc agaagaggag 161161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 161221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 161281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 161341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 161401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 161461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 161521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 161581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 161641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 161701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 161761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 161821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 161881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 161941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 162001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 162061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 162121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaagtaa tacaagatat 162181 cacatagtga ttctttttaa cggttaagtt agaaagggcg cacggtggat gccttggcac 162241 taggagccga tgaaggacgg gacgaacacc gatatgcttc ggggagctgt aagcaagctt 162301 tgatccggag atttccgaat ggggaaaccc accactcgta atggagtggt atccatatct 162361 gaattcatag gatatgagaa ggcagacccg gggaactgaa acatctaagt acccggagga 162421 agagaaagca aatgcgattc cctgagtagc ggcgagcgaa acgggattag cccaaaccaa 162481 gaggcttgcc tcttggggtt gtaggacact ctgtacggag ttacaaagga acgaggtaga 162541 tgaagaggtc tggaaaggcc cgccatagga ggtaacagcc ctgtagtcaa aacttcgttc 162601 tctcctgagt ggatcctgag tacggcggaa cacgtgaaat tccgtcggaa tccgggagga 162661 ccatctccca aggctaaata ctccctagtg accgatagtg aaccagtacc gtgagggaaa 162721 ggtgaaaagc accccggaag gggagtgaaa gagatcctga aaccgtgtgc ctacaagtag 162781 tcagagcccg ttaacgggtg atggcgtgcc ttttgtagaa tgaaccggcg agttacgatc 162841 tcgtgcaagg ttaagcagaa gatgcggagc cgcagcgaaa gcgagtctga atagggcgca 162901 tgagtacgtg gtcgtagacc cgaaaccagg tgatctaccc atgtccaggg tgaagttcag 162961 gtaacactga atggaggccc gaacccacgc acgttgaaaa gtgcggggat gaggtgtggg 163021 taggggtgaa atgccaatcg aacctggaga tagctggttc tctccgaaat agctttaggg 163081 ctagcctcaa ggtaagagtc ttggaggtag agcactgatt ggactagggg cccctaccgg 163141 gttaccgaat tcagtcaaac tccgaatgcc aatgacttat ccttgggagt cagactgcga 163201 gtgataagat ccgtagtcga aagggaaaca gcccagaccg ccagctaagg tcccaaagta 163261 tacgttaagt ggaaaaggat gtggagttgc ttagacaacc aggatgttgg cttagaagca 163321 gccaccattt aaagagtgcg taatagctca ctggtcgagt gactctgcgc cgaaaatgta 163381 ccggggctaa acgtatcacc gaagctgcgg actgttcttc gaacagtggt aggagagcgt 163441 tctaagggct gtgaagccag accggaagga ctggtggagc gcttagaagt gagaatgccg 163501 gtatgagtag cgaaagaggg gtgagaatcc cctccaccga atgcctaagg tttcctgagg 163561 aaggctcgtc cgctcagggt tagtcgggac ctaagccgag gccgaaaggc gtaggcgatg 163621 gacaacaggt tgatattcct gtaccacctc ctcaccattt gagcaatggg gggacgcagg 163681 aggatagggt aagcgcggta ttggatatcc gcgtccaagc agttaggctg ggaaataggc 163741 aaatccgttt cccataaggc tgagctgtga tggcgagcga aatatagtag cgaagttcct 163801 gattccacac tgccaagaaa agcctctagc gaggtgagag gtgcccgtac cgcaaaccga 163861 cacaggtagg cgaggagaga atcctaaggt gatcgagaga actctcgtta aggaactcgg 163921 caaaatgacc ccgtaacttc gggagaaggg gtgctctgtt agggtgcaag cccgagagag 163981 ccgcagtgaa taggcccagg cgactgttta gcaaaaacac aggtctctgc gaagccgtaa 164041 ggcgaagtat aggggctgac gcctgcccgg tgctggaagg ttaagaggag cgcttagcgt 164101 aagcgaaggt gcgaattgaa gccccagtaa acggcggccg taactataac ggtcctaagg 164161 tagcgaaatt ccttgtcggg taagttccga cccgcacgaa aggcgcaacg atctgggcac 164221 tgtctcaacg agagactcgg tgaaattata gtacctgtga agatgcaggt tacccgcgac 164281 aggacggaaa gaccccgtgg agctttactg cagcctgata ttgaatgttg gtacagcttg 164341 tacaggatag gtaggagcct tggaaaccgg agcgccagct tcggtggagg catcggtggg 164401 atactaccct ggctgtattg accttctaac ccgccgccct tatcgggcgg ggagacagtg 164461 tcaggtgggc agtttgactg gggcggtcgc ctcctaaaag gtaacggagg cgcccaaagg 164521 ttccctcaga atggttggaa atcattcgca gagtgtaaag gcacaaggga gcttgactgc 164581 gagacctaca agtcgagcag ggacgaaagt cgggcttagt gatccggtgg ttccgcatgg 164641 aagggccatc gctcaacgga taaaagctac cccggggata acaggcttat ctcccccaag 164701 agtccacatc gacggggagg tttggcacct cgatgtcggc tcatcgcatc ctggggctgt 164761 agtcggtccc aagggttggg ctgttcgccc attaaagcgg tacgcgagct gggttcagaa 164821 cgtcgtgaga cagttcggtc cctatccgtc gcgggcgcag gaaatttgag aggagctgtc 164881 cttagtacga gaggaccggg atggacgcac cgctggtgta ccagttgttc tgccaagggc 164941 atcgctgggt agctatgtgc ggacgggata agtgctgaaa gcatctaagc atgaagcccc 165001 cctcaagatg agatttccca ttccgcaagg aagtaagatc cctgaaagat gatcaggttg 165061 ataggtctga ggtggaagtg tggcgacaca tggagctgac agatactaat cgatcgagga 165121 cttaaccata tttttgaatg atgtcacatc tgttatctag ttttgagaga acactctcaa 165181 tttgtttggt ggcgatagcg aagaggtcac acccgttccc ataccgaaca cggaagttaa 165241 gctcttcagc gccgatggta gtcgggggtt tccccctgtg agagtaggac gccgccaagc 165301 agatttatta attctaccat gtttgtttat gaagctttat attattccgc agtagctcag 165361 tggtagagct atcggctgtt aaccgatcgg tcgtaggttc gaatcctacc tgcggagcca 165421 ttgcttccat agctcagcag gtagagcact tccatggtaa ggaagaggtc agcggttcga 165481 gcccgcttgg aagcttaaat gtattattac caaggtttct cataaggaga aagctttttt 165541 tattgcgata tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 165601 gggttcgaat cccgtcttcc gctccattta tcctaacggg atattgtaaa ttgaattgcg 165661 cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg gttcgactcc 165721 tctcgggcgc gccatatctt ttaatagaat agataggaaa tcgggaagta gctcagcttg 165781 gtagagcaca tggtttggga ccatggggtc gcaggttcga atcctgtctt cccgaccatt 165841 ttttatgggg ccttagctca gctgggagag cgcctgcttt gcacgcagga ggtcagcggt 165901 tcgatcccgc taggctccac caaaagtttt taaaaaagtt attgactttg aagaagtgac 165961 attgtatact aataaagttg ctttaacaaa gcggacaaac aaaatgatct ttgaaaacta 166021 aacaagacaa aacgtacctg ttaattcagt ttttaaaaat cgcacagcga tgtgcgtagt 166081 cagtcaaact actttatcgg agagtttgat cctggctcag gacgaacgct ggcggcgtgc 166141 ctaatacatg caagtcgagc ggacagatgg gagcttgctc cctgatgtta gcggcggacg 166201 ggtgagtaac acgtgggtaa cctgcctgta agactgggat aactccggga aaccggggct 166261 aataccggat ggttgtttga accgcatggt tcaaacataa aaggtggctt cggctaccac 166321 ttacagatgg acccgcggcg cattagctag ttggtgaggt aacggctcac caaggcaacg 166381 atgcgtagcc gacctgagag ggtgatcggc cacactggga ctgagacacg gcccagactc 166441 ctacgggagg cagcagtagg gaatcttccg caatggacga aagtctgacg gagcaacgcc 166501 gcgtgagtga tgaaggtttt cggatcgtaa agctctgttg ttagggaaga acaagtaccg 166561 ttcgaatagg gcggtacctt gacggtacct aaccagaaag ccacggctaa ctacgtgcca 166621 gcagccgcgg taatacgtag gtggcaagcg ttgtccggaa ttattgggcg taaagggctc 166681 gcaggcggtt tcttaagtct gatgtgaaag cccccggctc aaccggggag ggtcattgga 166741 aactggggaa cttgagtgca gaagaggaga gtggaattcc acgtgtagcg gtgaaatgcg 166801 tagagatgtg gaggaacacc agtggcgaag gcgactctct ggtctgtaac tgacgctgag 166861 gagcgaaagc gtggggagcg aacaggatta gataccctgg tagtccacgc cgtaaacgat 166921 gagtgctaag tgttaggggg tttccgcccc ttagtgctgc agctaacgca ttaagcactc 166981 cgcctgggga gtacggtcgc aagactgaaa ctcaaaggaa ttgacggggg cccgcacaag 167041 cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac cttaccaggt cttgacatcc 167101 tctgacaatc ctagagatag gacgtcccct tcgggggcag agtgacaggt ggtgcatggt 167161 tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc aacccttgat 167221 cttagttgcc agcattcagt tgggcactct aaggtgactg ccggtgacaa accggaggaa 167281 ggtggggatg acgtcaaatc atcatgcccc ttatgacctg ggctacacac gtgctacaat 167341 ggacagaaca aagggcagcg aaaccgcgag gttaagccaa tcccacaaat ctgttctcag 167401 ttcggatcgc agtctgcaac tcgactgcgt gaagctggaa tcgctagtaa tcgcggatca 167461 gcatgccgcg gtgaatacgt tcccgggcct tgtacacacc gcccgtcaca ccacgagagt 167521 ttgtaacacc cgaagtcggt gaggtaacct tttaggagcc agccgccgaa ggtgggacag 167581 atgattgggg tgaagtcgta acaaggtagc cgtatcggaa ggtgcggctg gatcacctcc 167641 tttctaagga tattatacgg aatataagac cttgggtctt ataaacagaa cgttccctgt 167701 cttgtttagt tttgaaggat cattccttcg aaacgtgttc tttgaaaact agataacagt 167761 agacatcaca ttcaagtaat acaagatatc acatagtgat tctttttaac ggttaagtta 167821 gaaagggcgc acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg 167881 atatgcttcg gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca 167941 ccactcgtaa tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg 168001 ggaactgaaa catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg 168061 gcgagcgaaa cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc 168121 tgtacggagt tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag 168181 gtaacagccc tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac 168241 acgtgaaatt ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga 168301 ccgatagtga accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag 168361 agatcctgaa accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct 168421 tttgtagaat gaaccggcga gttacgatct cgtgcaaggt taagcagaag atgcggagcc 168481 gcagcgaaag cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt 168541 gatctaccca tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca 168601 cgttgaaaag tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat 168661 agctggttct ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga 168721 gcactgattg gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca 168781 atgacttatc cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag 168841 cccagaccgc cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct 168901 tagacaacca ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac 168961 tggtcgagtg actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga 169021 ctgttcttcg aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac 169081 tggtggagcg cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc 169141 ctccaccgaa tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc 169201 taagccgagg ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc 169261 tcaccatttg agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg 169321 cgtccaagca gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat 169381 ggcgagcgaa atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg 169441 aggtgagagg tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg 169501 atcgagagaa ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg 169561 tgctctgtta gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag 169621 caaaaacaca ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt 169681 gctggaaggt taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa 169741 cggcggccgt aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac 169801 ccgcacgaaa ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag 169861 tacctgtgaa gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc 169921 agcctgatat tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga 169981 gcgccagctt cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc 170041 cgccgccctt atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc 170101 tcctaaaagg taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag 170161 agtgtaaagg cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc 170221 gggcttagtg atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc 170281 ccggggataa caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc 170341 gatgtcggct catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca 170401 ttaaagcggt acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg 170461 cgggcgcagg aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc 170521 gctggtgtac cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa 170581 gtgctgaaag catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga 170641 agtaagatcc ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat 170701 ggagctgaca gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct 170761 gttatctagt tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca 170821 cccgttccca taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt 170881 ccccctgtga gagtaggacg ccgccaagca attgcacatt agtgtaattt tttaaaaaag 170941 ttattgactt tgaagaagtg acattgtata ctaataaagt tgctttaaca aagcggacaa 171001 acaaaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca gtttttaaaa 171061 atcgcacagc gatgtgcgta gtcagtcaaa ctactttatc ggagagtttg atcctggctc 171121 aggacgaacg ctggcggcgt gcctaataca tgcaagtcga gcggacagat gggagcttgc 171181 tccctgatgt tagcggcgga cgggtgagta acacgtgggt aacctgcctg taagactggg 171241 ataactccgg gaaaccgggg ctaataccgg atggttgttt gaaccgcatg gttcaaacat 171301 aaaaggtggc ttcggctacc acttacagat ggacccgcgg cgcattagct agttggtgag 171361 gtaacggctc accaaggcaa cgatgcgtag ccgacctgag agggtgatcg gccacactgg 171421 gactgagaca cggcccagac tcctacggga ggcagcagta gggaatcttc cgcaatggac 171481 gaaagtctga cggagcaacg ccgcgtgagt gatgaaggtt ttcggatcgt aaagctctgt 171541 tgttagggaa gaacaagtac cgttcgaata gggcggtacc ttgacggtac ctaaccagaa 171601 agccacggct aactacgtgc cagcagccgc ggtaatacgt aggtggcaag cgttgtccgg 171661 aattattggg cgtaaagggc tcgcaggcgg tttcttaagt ctgatgtgaa agcccccggc 171721 tcaaccgggg agggtcattg gaaactgggg aacttgagtg cagaagagga gagtggaatt 171781 ccacgtgtag cggtgaaatg cgtagagatg tggaggaaca ccagtggcga aggcgactct 171841 ctggtctgta actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct 171901 ggtagtccac gccgtaaacg atgagtgcta agtgttaggg ggtttccgcc ccttagtgct 171961 gcagctaacg cattaagcac tccgcctggg gagtacggtc gcaagactga aactcaaagg 172021 aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 172081 accttaccag gtcttgacat cctctgacaa tcctagagat aggacgtccc cttcgggggc 172141 agagtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 172201 cgcaacgagc gcaacccttg atcttagttg ccagcattca gttgggcact ctaaggtgac 172261 tgccggtgac aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgacc 172321 tgggctacac acgtgctaca atggacagaa caaagggcag cgaaaccgcg aggttaagcc 172381 aatcccacaa atctgttctc agttcggatc gcagtctgca actcgactgc gtgaagctgg 172441 aatcgctagt aatcgcggat cagcatgccg cggtgaatac gttcccgggc cttgtacaca 172501 ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac cttttaggag 172561 ccagccgccg aaggtgggac agatgattgg ggtgaagtcg taacaaggta gccgtatcgg 172621 aaggtgcggc tggatcacct cctttctaag gatattatac ggaatataag accttgggtc 172681 ttataaacag aacgttccct gtcttgttta gttttgaagg atcattcctt cgaaacgtgt 172741 tctttgaaaa ctagataaca gtagacatca cattcaagta atacaagata tcacatagtg 172801 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 172861 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 172921 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 172981 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 173041 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 173101 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 173161 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 173221 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 173281 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 173341 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 173401 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat ctcgtgcaag 173461 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 173521 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 173581 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 173641 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 173701 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 173761 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 173821 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 173881 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 173941 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 174001 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 174061 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 174121 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 174181 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 174241 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 174301 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 174361 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 174421 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 174481 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 174541 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 174601 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 174661 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 174721 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 174781 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 174841 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 174901 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 174961 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 175021 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 175081 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 175141 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 175201 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 175261 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 175321 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 175381 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 175441 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 175501 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 175561 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 175621 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 175681 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 175741 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 175801 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 175861 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag caagcttaaa 175921 cccagctcat tgagctgggt tttttgtttt atatctgtgc cgatttgctt tcgtcagtat 175981 ccattttatc aagcttctgc tttttaaagt tttctaatac ttttgaattc caatacaatc 176041 cctagcatga tcaacatgag agtcataaat aatcaaaatg cagtttgtac gggagactca 176101 tccagactcc atccgactgc gattggcagg atagagccgc caatccattg gcagcgaaca 176161 gcatgcttgt cgtttgttct gtttttccat gataaaattg attggtgaca ataaaataat 176221 ggcgaacatg ccggccataa ataagtccta agaaaaaact aagaataatc cctgcaaaag 176281 ctgttttatt gattgccaaa atacagagtt aaatgaggcc gctcatattt atcagcctga 176341 gataatgatg ataggttatt ttttcggaaa ccagctcggg ttgccaaatg agagaaaaga 176401 tattactgtc attaaaacga ttcttggttt catccggata tgataaaatg tctcagacta 176461 tatttgagcc atttttttct tcagcaatca tcttgcgtaa ttgataaaaa tttattatga 176521 tactctttgt atgacaactc cttgcctcaa tacaatatac tcaacgtttc cccgttttct 176581 ccggtcgttt ttcttttcat tttctcccgt aaaataaaaa aagctcccaa tacaatagat 176641 atggtgcgga tttatttttt actaaaaagg agtcgttata tttgaataat agttttacat 176701 taaaacagca atggttcggg aatatccgaa aagacattct tgctggcatt ttagttgcgt 176761 tagcgttaat acctgaagcg attggctttt ctattatagc cggtgtggat ccgatggtcg 176821 gtctttatgc gtcattttgc atagccatta ttatttctat ttttggtggc agacctggca 176881 tgatttcagc tgcgacaggc tcaatggcag tcgttatggt gtcgctggtt gctgatcatg 176941 ggcttcagta tttatttgcg gctacgattt tgacaggcat tattcaggtg attttaggta 177001 tcagtaaaat tgcaagatta atgaaattca tcccgcgttc tgtgatgatc gggtttgtga 177061 atgcgctggc gatccttatc ttctctgcgc agcttcccca gtttgaaggt gcttcttgga 177121 gcatgtatgc gatgcttgcc gggtcgttgg ttattattta tgtgctgcca aggtttacga 177181 ctgctgttcc gtctccgctt gtggcgatta ttgtgatgac aattattgcg gtcactttcc 177241 atgtggatgt gcggacggtt ggtgatatgg gcaatatttc tagttcattg cctcatttct 177301 taatccctga tgttccgttt acctttgaaa cactgcaaat tatttttcct tattcaattg 177361 ctttagcgtt tgtcgggttg cttgaatctt tgctgacagc acagattatt gatgaaatga 177421 cggatacgga tagtgataaa aataaagaga gccgcggaca gggaattgcg aatatcgtga 177481 ctggattctt tggcggaatg gcaggctgcg ctatgatcgg acaatctgtc attaatacaa 177541 aagcgggcgg tcgcggacgt ttgtcagcat ttgttgccgg tgcttttctg atgtttttaa 177601 ttgcggtgtt aagtcatgtc gtggtgaaaa tcccaatggc ggcgttagta gctgtaatgg 177661 ttatggtgtc tgtcggcact tttgattggt cttctttaaa aggtctcaaa aaagcgccgc 177721 tcacggactc gattgtcatg gttgtgactg tggttacggt tgttgtgacg gatgacttat 177781 ctaagggtgt atttgtcggt gttcttttaa gtgccgtgtt ctttgtagca aaaatctcga 177841 agctgaaaat cgtttctcat gcagaggatc aaaagcttag aacgtatcaa gtgaaggggc 177901 aaatcttttt tgcgtcagtg actgatctta cgaatgcgtt tatatatcaa gaggatattg 177961 agcgggttgt gattgactta actgaagctc acgtatggga cgattctggt gcggccgcac 178021 ttgataagat tgttgcgaag tttaaggaac aaggcattga agctgagtta aaaggtttga 178081 ataaagcgag taaatctcta atgaaacaga tggcataaaa tagagaagcc cagatgaatg 178141 agatctgggc ttttttatat aacatacact taagcagcat tgatataata gagagaagag 178201 aaattttaaa taggggactt gcatatgatg cttcagaagc tgaaccgtgt attggggaga 178261 gtgatgccgc tgttaacgcc gactagtgtg gtgctgggcg tgctgctgtc tcagttttta 178321 aatgggtatg aatgggctgt gccttggatc tttgctttta ttacgtttgc aggcagtttg 178381 agcgcgaact ttcaatcttt gagacatgca ttgtctcatc ctctccctat gattcttgca 178441 ctattcgttc ttcatatttt catgccgctt tttgcttggg gcagcggcca tcttatattt 178501 aaaggtgatc ctttgacgat taccggttta acattggctg ttgtgattcc tacggggatt 178561 acaagcttga tttgggcagc gatgtacaaa gggaatgtcg gtttgacact ttcgattatt 178621 ttagttgata ctgtgctgtc accgctaatc gtaccgctga gtctttcatt gctggccggc 178681 gctcaggttc acatggatgt gtggggaatg atgaaaggtc tgattgtaat ggtcgtgatt 178741 ccttcttttt tgggcatgct gtttaatcag atgtcatctc cagaaagaac tgcgtttgtg 178801 agcagtgcgc tgtcgccttt ttcaaagctt tgcttgatgg cagtgattgc gattaacagt 178861 tcagcgattg ctccttattt caaatccatt gatttgagat ttgcaggaat agctgtaacg 178921 gtattcttta tcgcgttaac aggttatgcc gctgcttggc tgatcggaaa aatgatgaaa 178981 aggcggcaag aggaaatagt ctctcttata tttacgggag gcatgaggaa tattagtgcc 179041 ggcgcagttc ttgccgttac gttcttcccg tctcaggttg ccgttcctgt tgtgatcggc 179101 atgctgtttc agcagatatt ggctgctttg tttggctata tgctgaatcg ttttgaatta 179161 aaaccaatgt tgcagaaggc ataaaaaaac cgctcatagg gttgagcggt tttttccgta 179221 tagccattcg agcgcgttga tgaactgttt gcagaaatac ttgtggtggt gcaccgctcc 179281 tttttcaatt gaaagacaca actggtcttc agtgaagcct ttttctttta gactttgatg 179341 aacttgcttt gtttttttca gcatatgtcg ctgaatggat tgtttttcac ggccttcttc 179401 actcccgata gacatgaaaa cacgtgcagt gccgggcttt aaagaagata tatgaatggt 179461 ttccgctgcg ttctcgtacc agtatgaacc tgatatagag cctattttcc cgaacattga 179521 cggatatttt aatatggcga acattgagat gaggccgcct aatgaggcac cgatcattcc 179581 tcttgactgc ggttccctgg tgacgttcca gttttcttcg attagcggaa tgaactggtt 179641 cgttatatca gacagatagt gatatcccat tccgccgaag tccgtgaacc gatcactgag 179701 tgatgcagcc ggccatgggg tgtattcatc aagccggttt tcgggttcga taccgatcag 179761 cacgagttca gggagccttt gctgttgaaa ggcgctttct agtaattcga tttggttttg 179821 gaacaaagaa ctgccatcct gcacgtaaac agcaggaaat cccccgctgt ctgtgctgta 179881 ggaaggaggg aggtacagcg tgaacctcct gttgccggct ttgtgttctg aaagagatcc 179941 tttcaagcat tctccccctt tttttgcttg aaaagcagat ataagaaata aggaactccg 180001 aggatcgcca aaatgatgcc tgcgggcact tctgcgggct gaaaaaacag ttttccggca 180061 aagtctgcgc ttatcacaag aagcatcccg attaaaccgc tcagtggcag gatatagcga 180121 tgttcgacgc cagccagtct ccgtgagata tggggagcaa ttaagccgac aaacgccata 180181 cttcccgcta cggagacaca ggcgctgatg attgctacac aggcaacgag aaggatggtt 180241 ttttctttat ttgatgaaat accgaggctt ctgactgtgt cttcatcaaa acgaatggtg 180301 tcgagcaggc gggatttgcc gataagaatc ggtataaaca gcagcatcca tgggagtaca 180361 gctgtaatat acgtccagtt ggcagaccag atgcttccgt ttttccacac catggccatt 180421 tgatagtctt gcgggtccat ttttaaagat aaaaacaaag acagggcgct gaatcctgaa 180481 ttgatcgcaa tccctaccaa aataattctt cctgaatcta aattgcctct gtgccatgca 180541 aatatgtaaa tcaggatcgc cgcgatgagc ccgcctatca atccaaagag cggcattccc 180601 atcgctgcag ctatggatgt cacttccttc tggccttgga ataagagcat aaacgctaca 180661 atgccagctc ctgcccctgc gttgattccg agaattccag ggtcagcaag cccgtttctc 180721 gtgatggcct ggataacagc gcctgcaatg ccaagaccga gtccaataat agcagccatg 180781 acaacccgcg gcagtcttaa atcgaacagc aaaatttcat actgcggatt cgggtcgatt 180841 tgaaaaagag tggagagcag ctcagcagga cgaacagaaa atgatccgct cgttaagctg 180901 aaatagctga caacaagaat caaagcgatg aacaatgcat attttttagc cattttgctc 180961 ccctcctttt cgtttaatta aataaaggaa gaaaggtacg ccgataatgg atgttacgac 181021 ctcaatcggt gtttcaaacg gatagttgat aaatctgctt gcgagatcac acagggttaa 181081 aaagattccg cccaaaatac aggaacacgg aatcagcctg ctgtaatcag agccgacgag 181141 aaatctcgtg atatgcggaa caaccaaccc gacaaacgca atttttccgg ccagcgctac 181201 ggcactgccg gttagaatga tgacggaaag catcgccatg attttaatgg tttttttctt 181261 ttgccccagg cttttagaaa tgtcgtcccc taatgataca gcggttacct ttttgctgag 181321 agaaatggcc attataatgc caatcaggaa aaacggagcg gcaagcttca ggaaatctgg 181381 actcatttga tgaagtctgg cactgtacca gaaactgaga tcctgagaaa tttgaaaata 181441 aatcgacatg gccgctgata agctgctgag cagcatgctt gtgactgtgc cgatgatggc 181501 gagctgcacg ggggtaaatc cgtttggcat catggcggca aggccgaata ctaacaccgc 181561 tcctaacgct gagccgataa aagagtatat catcatttca atcgaagatg attgcgggag 181621 cagaaccatg caaagcgtaa tgataaacgc tgaaccatct gaaacaccca taatggatgg 181681 cgaagctaaa taattgcgcg taatgccctg cataagcgct ccagaaacag caagggctgc 181741 ccctatgagc agagcgccgg cagcccttgg aatccgggaa tgccatataa tttgatggtc 181801 tgtgtttccc ggatcgaaat gaataagaga tgtaaaaaca atatctgtgc tgagatgctt 181861 tgccccataa aggattgaaa gcaaaagtga cagcgctata gcaaatggag aagtaatcaa 181921 tatgatacgt gtccactgtt ttgaatacat acaaaaacct actctgaatt agttttgtgt 181981 caatttttca gcagccgctt tcaggaaacg gactttgctc caagctgtgc cgccttgtgc 182041 gagagggtcc actgagttga catacacatg gtcttctttg actgctttaa ggcttttcca 182101 gattggattt ttctctaaat cttttaaggc atcaggtttg tctgcatttt catcatcaga 182161 aaattggacg aaaatatggt ccgggttcat ttcacttaat ttttctaatg aactcagctc 182221 ttgcgctttt gcagccttta cttcgttcgg cgccttaagg cctaaatcac cgtatagtgt 182281 ggagttgaaa tacacctgtt cagggtaaat gtaaatgttg ccttgtctga ttctgatgac 182341 aagcgctttt gaatctttcg ctttatcgtt gatttttgtt tttatttctt ttagatcctg 182401 ttcatagtct gcaataattt tctttgcttt tttctctttt ccagtcagct gggcaagaag 182461 catcatgttt tccttccagt ttgaagagat atgagaaact gggatcgtcg tgcctgctgt 182521 gctgattttt tgcagcgttt tttccggaaa ctttgttgaa gcaaggataa catctggctt 182581 catttcaaga atcttttcaa tatttggctc cattttttct ccggttggtt cggctttatc 182641 agtgatgtct ttgaacatat cagggaattt gccggagaat gaaattgcgc cttgcggatg 182701 aacgtcaagc aatttcgcgt cttccattga ttcaacgctt cccgtaatgg caattttgtc 182761 tgtcggtaca gttacttcat atgttttatc aaggtattca attttcttct tctcagatgc 182821 tgtgccgctt gccttgctgg cagttgattc atttttgctg ccgcaagctg ccgccgtcag 182881 cgcgagaagt aagattaata aggtaagaga tatctttttc atctatagag cctcctgttc 182941 aattgataac tattatcaat tggaattata gagaatgaac agatataaca ccatggacaa 183001 attcctgatt tatcatggac aatctccgga tagtaaagaa acagtttgct gaacgatgcg 183061 ttcgtgcccg caagctgagt attcattcca cgggtcaagg gatagaagat aaacacggtt 183121 atctcgtacc gcgcttaggt tttgccatgc ttctgtctgc tgtaattgct ggtagtaagc 183181 tatggtctcc ggctctttaa aaagaaaaag catcatacag tcagcttggt aatttgcgat 183241 attttctaac gaaatcgctt gttctgaagg tgtgtcagcc gttgttgccg agctgaatcc 183301 taaatcccca aagaaaactt cgcggacact tcggttatga gccagataga agttttgctt 183361 atgcagcctc aaaaagagaa aacgcagccc ttgaacgtgc tgaagtgttt ttttggcggc 183421 cgttgtctgc tggtcataat ccgctagcca cttttctgct tcggactcct cctttaaaaa 183481 tgaggcagtt tgcagaaagt gggttctcca gctttcttct gaaggaaggt acatgacttc 183541 tgcgatgcga ttcaggcgat cttgttcttc tggagaaata gaatccatgc tgacaatcac 183601 atctggttct gcctgtgata acgtgtacag gttttcttcc cacttttcat taaaccggta 183661 tgcactgagc tggacgggta tatctgtcga ataatgctga tagtagtaag acgtccattt 183721 cggatgcaga gcggccgcaa aaggtatgtg gtgaagaggg atgagatggc ccattgtgcc 183781 ccttccgtat gcggcgattt tctttcggcg ttttttcata tagcttgtag gtgaacagcc 183841 tgtatatttt ttaaagattc tgctgaaata aaattcatct tgataaccgg tttggtgtgc 183901 gatttctttc aatttgcagt ttgattttgc catgagccgt tttgcctttg tgattcgtgt 183961 tttcgtaata aattctgtta cgctctgtcc tgtccatttt ttaaagcttt cactgtagtg 184021 tttggcactg attcctgcca tttgcgacag ctgggcaagc gtgatttttg tatcggcatg 184081 ggtttcgata tagtgttttg ttttttcgat tgctgaatgt gtatccgttt gatcagataa 184141 actggcagta aaaagatcat aaatcaggct ttgtacttca atcacacatt ttagctgaga 184201 aagctgagac gattcattcc atagtgcggc aagctcttga agccggactg caagattttc 184261 gatatgtgaa acattcataa gcttcagttt ggctaattcc gattctgtgc acggtgtgaa 184321 aatatcttgc ccggtttcct tgatatagct tagaagcctg attatacagg catctatatg 184381 tccatcggct gctggcgtaa agccaaaggt ctcgttaggc ggacaaacat aaagtgtctt 184441 tttttgcaga ggattggtgt ttgttccgat cgaaatatag ccgtttcctt ttaaatgaaa 184501 aatcagcacg aatgaatcgg ctaattgctg ttctgagaag agatcacttg tcttttttag 184561 atattcaatt tgtactggtt gataaatcac tgcattttgc acgagtagac caccttttca 184621 gaagctttca attgataatc attttcaata aaaattgtac caaataaatg aaagttttcc 184681 tatataaagc gggtgggttt ttagcatgaa aaaaaccctt acttatgtgt aaaagtaagg 184741 gtctttcgtt caataagaat atgttacacg tgtaacatac gatgcttatg ttctaataaa 184801 tgagatactt ttttcttgtt ttgctgaatt gttggagtgt tttttcatag ctgtttatga 184861 tgttctcaac cgaagttcca ttttcaattt ttgtcctgat ccagccgttg cctgccagtt 184921 tatcgaatga acctgttgac aggaactcaa aatcctcagg atagagatcg tgtatggttt 184981 taatgactga aagacccgtt ttaacggctt caaacttatc tctgtctgtc acatagagct 185041 gcacaccgtg gcaaagcgtt ccttgatgtt tagaaaacgt cggtgtgaag gatgctgccc 185101 taaatgtaac gcccggcaaa tggaggctgt ttaatgtttc ttcaagttct gtgcttttga 185161 taaagggagc tccgatcaat tcgaatggct ttgttgtccc tcgcccttcg gatatatttg 185221 ttccttcaat cagcccggtt gcaggataaa caaatgtgct ttccaccgtc ggcatgttag 185281 gcgaagggag gacgaaaggc aatcgggtat cgtcaaaatc catttttcgt ttccagtgtt 185341 tcatttttac cactgtaaga tcggcatcaa tactaaattc tttgttgaac agtgaagcca 185401 attcgcctat cgtcatccca tgcttcaatg gaatgggata caatccgaca aatgaggcgt 185461 attcaggttc taagattggt ccttcaatat gattcccgcc ttgaggattc ggacggtcca 185521 gcaccataaa tggaatgccg ttttctttag cggcttccat tgcgtatgcc attgtataaa 185581 tgtacgtgta gaaacgggtc ccgacatcct gaatgtcaaa cattagaata tcgacatttt 185641 taagcatttc tggagtcggt tttttcgttt ttccgtagag gctgtatacg ggaaccccgg 185701 ttttttcgtc aatgtaagag cctacttcgt ctccagcctg ggcgtcaccg cggacgccgt 185761 gttcagggcc gaataaagct gtcagtttga tatccgggtt ctcgtaaagg atatcgacac 185821 tgctttttag agatgtgttt actccggctg gattggtgat cagtccgatg cgttttccct 185881 tgagctgttt tttatagtct ggcaagagcg tgtctatccc agtctggact ttaggttttt 185941 tagctgtttg attctttgaa tcgggtgaag cagaggcagc ggttatcgtt ccgaacatca 186001 tgagccctgt cagaaaagcg aatattgttt ttctcatgtg tccctcctta ttaaagcggt 186061 cttcccgttt tgatatttaa tccgtagcca agtgggtaaa gggtgttccc tggtttcgtg 186121 actgacggaa tgtcaactgg aagtgtgcct ttaggttttg cctggccgaa tatcgccatc 186181 actccggccg gaatattagg ttgaagataa cggccatttg cgtatccttt aaagccatag 186241 actgcaatca gtgcttttgc ttcttcgaaa ttggctgcgt cataggggtt gcgcaggctc 186301 attaagacaa atggtttgtt gtgctgcagt gcggctttca tgacagctct cggaaacacg 186361 gtggcccatt tgcttgaatc tgatattgtg tcgtcgatga caccgtcgtt gacgacaggg 186421 tcatttttga cgacatagga gccggtaatg atataatcag cctcttttac ttgtttttca 186481 tgctcggtct taaatacttg gctggcaaag ttcattttgc tgagggatac gggtttgatt 186541 ttctttcgct tgatgagatc gtgaatggtt tgttcgattg aagcagtttg ttcttcgtaa 186601 ggtgccacaa ttaagattcg gctgcctttt ttaggcttga acggcaaagt gtgctgttca 186661 ttttttaata cagttactgc tttttcagct aattttttct ctgctttcag gtgctgcttg 186721 cttcctacga tttttttggc tttggctatt ttttcttttg tactgtcgct gtttcgcgct 186781 ggatacatgc cgcgttttat tttcagggaa atgattcttt caactgaatt gttgatttgt 186841 tgttcaggaa tatccccgtt tttcacggct tctttcaaag cttgaataac acgtgcgaat 186901 ttctgttctt ctttcaatga agtgactgag gctggcatta atgcaatatc gacaccagct 186961 tttacggcca tgaccacagc ctcttcctgt ccgaaatgat ctgcgattgc cttcatattg 187021 agcgcatcgg taacgatgac cccattaaag cccatttcct gacgaagaag acctgtcatc 187081 actttttttg aaagtgtagc tggaaccaga atgtccgatc catcgagttt gcttttgtaa 187141 gtggtgtcat caaaggcggg aaactgaaca tgggctgtca tcaccatatc agcaccagca 187201 tcaattgctt tttgaaaagg ataaagctcg acctcacgaa gccgttcttg gccatgggaa 187261 acgagcggca gtccataatg gctgtcaacg tccgtgtctc catgtcccgg gaaatgtttg 187321 agggcagacg cgatatcctg ccgctgcaac cctttcatcg tatataaacc gaggcgtgat 187381 gtcagttctc gattggagct gaatgaccgt acgccgatta caggattatc aggattattg 187441 ttaatgtcca cgacagggct gaaatctgta ttgatgccta aggcagagag ctcttttccg 187501 atgatgctgc cggtctgata cgcattgatt ctgcttctgg ctgcgcccag cgccatattc 187561 cctgggaaat tagtgccctc ccctaacctc gttacaatgc cgccttcctg atcaatactc 187621 agcatgagcg ggatttttgg acttgccttt tggtaatcgt ctgtcagttg gacagtttgt 187681 tttgttgttt ttacattttc tgcaaaaagg atgatgcctc cgaattgata tttcttgacg 187741 aggctggcga cttcatcatt catttttgta agggcttgcg gagaggactc gccttccttt 187801 tgccaatttc taaaatcagg catcagcatc tggccgagtt tttcatctaa cgacatacga 187861 ttgacaatct gattggcatc gattgcacgt ttggatgcag aggcttctgt ctgtctggcc 187921 ccgaaaaagc atgaaagaaa gagaacggct gaaaggataa gcggaaagac aggtctcata 187981 gaaacttcct cctatcgtct aatcattcac tccatcgctt cataaatcgc ggttatgaca 188041 cttccataac tgcctgttgg aaattggtca ccttcaaaga cgttcggatt ttcttccgga 188101 tcaataactg gtgtatgctt tttatttgtt aacaatgcga tgcctaaatt gtatgctgga 188161 tcaataattg taactgtccc cgtccagccg gtatgcccgt aagcattttc gctggcatga 188221 gggccaaaca tccattccat gcttttactt ccgttccgcc tccagccaag agcgaatgtc 188281 ggatctgttg ctgaaggtgc tgtaaacagg tcggctgttt tctgatcaaa taaagaaatg 188341 tttcggtatg aacctttgtt taacatgact tgcagcagta tggccatatc atctgcattt 188401 gagaacaatc cggcatgccc agacacgccg tccattgagt aaaacgcttt ttcgtcatgc 188461 acctctcctt gcagcgtgtt tgtgcggatg ttagggaatt gaataacgcc gtcacgtgta 188521 ttgcccatgc gttcagtagc tgcgaactgt ttcggtttaa agcccttttg cagcggattg 188581 tacaaggtat gcttcagcct gagcggtttg tagagctctt gctccgtgta gacatcaagc 188641 ggtttgccgg tgagtttttc gacaatacat ccgagtagca tatatccaat gtcactgtat 188701 acgtgttttg tcccggtttg ataatcgagc ggaattttcg tcaaatattc aatcgttttg 188761 tcccgttctt gggaatagta cttgccggct ttttccggcg tgtaaaagta aaagcttgat 188821 gggagccctg attggtgctg gaggacatca atgacacgta tcttgtcttt tccttttatg 188881 aggtcacccg gctgatcctt gaaacccggc aaatatgcag aaactttttc atagacgtca 188941 agttttcctt ggctgactaa gcgctgcaat gcaaaatttg ttgcgtacat ttttgtattt 189001 gaggctaagt caaacatcgt gcgggttttc attttggccg gacggcgcag cagttctgat 189061 ccttcgtact ttttactgta gccgtatgct gcttttttta tgatgcgtcc atccttcacc 189121 accacaagaa cggcgcctgg aaatcctgct gcaatatccc gttctatcat ctgatctacc 189181 ttccttagct tcttcgtcga gaattgtgca gtttctgcat ttatgatttt cggctcaatc 189241 aagttgcctg ctgtttgtgc gaaggtttca tttggcgcaa atatcgatag ggttaaaatg 189301 gcactgaata tgaacagtgt ctttgttttc acaggctagc ccctttctgt gcttctatcc 189361 cgtttactat ccctaaaaca gaaacaattt aatcgaactg agaagccatt tcatctttat 189421 atccgaatgc ataggtcaat aaaaaaccgg ccgcgtagga aataaagagc ccaacgatat 189481 acaggatgat ttgcgaaggc aggactagaa aagatagcgg cagtccggag acaccaatcg 189541 caatggtggc tacttgaaaa taagcttgaa aggcgccgcc gattccagct cctaaacatg 189601 ctgttaaaaa cggacggcca agcggcagcg tgactccgaa aataagcggt tcaccaatgc 189661 cgagcagtcc cgatggaagc ccgccggcga ttgctttcct cagtgttgtt tttttcgtct 189721 tcacgaaaac ggcaaaggcc gcgcctacct gtcctgcacc tcccatagcc aaaataggga 189781 gcagaggatc attgccaatt gaattgatca gttccatgtg cacaggcgtc aagccttgat 189841 gcagtccggt tacgacgaga ggaaggaagg ttgcgcccag aataaagccc gcagcgatgc 189901 cgccgatgtc caggatggac agtaggccgg atgtaatagc atcagaaatg aatccgccta 189961 aaggcataaa tacgacatac gttacgattc cggtgattaa cagtgaaacg gtgggtgtga 190021 caatgatatc aagtgattga ggaataaaac ggcgaataaa ttgttcggtg taagcaatga 190081 atatggctgc gaaaaggacg ccgatcagac ctcccctgcc cgggagaagc tcttctccaa 190141 ataaactgat ttttgcgatc tccggattga taatcaagat cccggccaaa gccccaagtg 190201 cgggtgtccc gccaaattct ttcgaagcgt taataccgac gagaatgccg agataagtga 190261 acagccctga tccgatgact gtcaggataa tcgcaatttg tgagtctgca gagagccagc 190321 ctgcttgaat aattgctttg gtaatcccag taattaaacc ggaagcgact agagcgggaa 190381 taagagggat aaaaatgctg gcaattttac gtaagaaaag tttaaaagga gtggcatttt 190441 tccgattgat atcggctttc tttttggccg ctgcttcttt gacatcggca ccttcttctg 190501 ctgacacgag ctttgagaaa gcagctgtaa catgattgac aactcctgtg ccgaggataa 190561 tttgtaaggt ttcagcttca acgaccccca atacgccgtc aagctttctt aaagcctgag 190621 catccgcttt gctttcatcg taaggcgtaa tgcgcaggcg tgtcatgcaa tgcgtatatg 190681 aagaaatatt ggattttcct ccgcatagct caaggatttt ctgtgcgaga tgatggtagt 190741 tattttcttt gctcattaaa acccctcccc ttcaagatgc cttattttat tctcatagat 190801 tgtatggctg ctctcgtttt atctatataa ccggttgtcg tttcatactg ctcagccgcc 190861 atgcctaaaa acaaaacatc aattataaaa agctgggcga ggcgggaaga agtggctgca 190921 cttcgaatca aggcttcatt ggaatgggct gtatacaaag ggacatcagc cagtgcggag 190981 acggatgtct gactgaattg tgtgaggctg atcgttgtga tgcctttttc cttagccatg 191041 gcgaacagtt caacgatttc ctgtgtctct cctgaaaacg aaatggcgaa tacgatgtcg 191101 tctttatctg catttgcgat taaagatgcc acaagatgag tgtctgtaaa cgcggttgct 191161 tgtttatgaa tgcgaagcca cttttgctgg gcgtccttgg cgacaatgcc ggaagccccg 191221 aggccgataa aatgcacggt atgagctttg agaagcagag aaaccgctcg ttcaagctct 191281 ttgtagtcca tcaggtctga agtatcctga atggcttgaa tggcattgcc ggccgttttt 191341 tcggaaatgg agggcagcgg ctcgtgggga acaatatccc ggtagccctg aaacgtaggc 191401 tttgccagat cgcctgctac tctcattttt aaatcttgaa atccttttaa accgagtgat 191461 ttgcagagcc tgatgacggc agcgtcactt gaattggcta aggcgctgat ttcgttgacc 191521 gtgctttcga ttgctttgtg gggatgggct aggatataat ctgcaagttt gcgctcggat 191581 ggagggagct tatgcttcat tgattggatg atcgctaaac cgcctgtggc cattctagtt 191641 ctctccttat catggatggt aatgttcgat tgctttgtca atgaaaccgt ttgcttcatc 191701 gagtaatgtc tgtgcttgtt tctgatctgt gcttgttttg agcatgacga ttgctgtttt 191761 gacgtgatga tcggcttgtt ccagagtgta tctggctgtg tcgtatgaag cgtttgtaag 191821 gctttggatg atgctgatgg cgcgttcttt tagttttttg ttgctgacgt tgacgtctac 191881 catcaagttt tcgtaaacct tgccgatttt gaccattaca gcggtagata tcatgtttag 191941 aatcatttta tgagcggttg cggctttcat acgtgttgat cctgtaatgg cctcaggtcc 192001 gacgacaacc tcaatgctgt gatccgcatc cttgctgatg gcggaatttt cattgcaagt 192061 aagggcgatg gtgtgtgctc cgactttacg ggcgtatctt agggcgcctg cggcgtaggg 192121 tgtgcggccg cttgctgcga tggcaatgac ggtgtcattt gaagtgagct gtatgtttct 192181 taaatcttca gctcctgctt cttcactgtc ttcaatgccc tctgctgcct gtaaaaaggc 192241 ttcggggcct ccagccatga ttccgatgac ctgatctggg cttacgctgt aggtgggagg 192301 acattcaaca gcatccatga cgccgagtct gccgcttgtg ccggcgcctg tatatatgag 192361 ccggcctcca ttttgaaacg attcatatgc gcagtctaca gctgttttga tgtcggggag 192421 aacctcctga acggctgcag cgactttcat atcttcgttg ttgatcattt taaggatgcc 192481 gagagtgttt gctttgtgga tttcaactgt ttgactattg cgtgattccg ttgtaagacg 192541 gtgaaggttt aatggttctg acatgaggat gccccctgtt ttaaaatgat atatctcaat 192601 attcagtata ttcatttctg ttatgatatt tcaactatgt ttttaaattt ttgaaatttt 192661 atttcactta agactataag aaatgatgaa ggatcaactg ttctccaagc ggcccgattc 192721 ttcgccgtcc tttatcaagg aacccgcttt tcatataaag gtgttttgcg cgtatgttca 192781 gatgattgac ggccaagatg atttcgtcgc accatggaaa atatccgctc acaaaagcgg 192841 gaagcaaaag catggctttt ttcgcatagc cttttccgtg atgcacagcg gttaaagaca 192901 gggagctgag cagtaaagca aatggattgt tagaatagga agcaagcgtt tcttttgatg 192961 catgtaaaat gaaaaaaccg actggaaggt cgtcttttaa gatgacaacc gggtatcggt 193021 cctgtatgcc cagagcctga gacagcacct ctttcgggag ggaggtaaag cgtttgtcat 193081 cgttggtgag cgtgaatgat tggagctcgg gcaagtgttc aggcttatag aaggataaag 193141 aaatgtcttg agtcatgggg tggcctcctt acaatatgtc gttaagctcg ttttccgaaa 193201 tgacgcggta gcccgcttgt tttaacagtg cggcggttac tccgctgccg gtgatttttt 193261 tgccagagaa tgtgccgtta tagataaaac cgcttccgca agatggactg ttttctttta 193321 atatgacggc agaagcgttg atttcttttg cgtaagccaa tgttttcgcg gcgccttcca 193381 tatatagttc tgtgacgtct tctcctgaag ctgtcacgat tttcgctgtt ccattgagga 193441 catcctcgcc agtgcctcct atgatttctg cgggttcgcg tggggtagag aagccgccga 193501 gaagttcagg gcaagccatg actgctttct tttcatcgac tagttttctg attttctccg 193561 acgctgcgtg agagccgtta tatctgcatt caatgcctcc aaggcaagaa ctgactagaa 193621 tcatattggt ttctcctctc ttgctttgct tgtctctatc ataaaataaa tggctttagt 193681 tgggaggctt tttcagttaa aaaaggagtt aaaaagtttg aaaataaaaa atttaatttt 193741 cctctttaca aacagggggt gacctgtata taataacttt tgtcagctcg acgagaacac 193801 aacggcccgt tggtcaagcg gttaagacac cgccctttca cggcggtaac acgggttcga 193861 atcccgtacg ggtcaccatt tggaggatta gctcagctgg gagagcatct gccttacaag 193921 cagagggtcg gcggttcgag cccgtcatcc tccaccatct tgccggtgta gctcaattgg 193981 tagagcaact gacttgtaat cagtaggttg ggggttcaag tcctcttgcc ggcactgttt 194041 tttcaaaatt ttatgtggag gggtagcgaa gtggctaaac gcggcggact gtaaatccgc 194101 tccctcaggg ttcggcagtt cgaatctgcc cccctccacc attattgggc tatagccaag 194161 cggtaaggca acggactttg actccgtcat gcgttggttc gaatccagct agcccagtca 194221 cagacacctt tgatcaaaag gtgtcttttt tcttttcgga aaaatcattc caacttctaa 194281 ctgttcagtc tgtataataa ttttaaaaat atgttaaggt agtttattca cgaattacca 194341 tctacaccct gccaaaaatt tgataaactt attttataaa aaaattgaaa ccttttgaaa 194401 cgaagctcgt atacatacag accggtgaag gcagaggtta gataaatatg gaaatgatga 194461 ttaaaaaaag aattaaacaa gtcaaaaaag gcgaccagga tgcatttgcg gacatcgtag 194521 atatttacaa agataaaatt tatcagcttt gctaccgtat gcttggcaat gtgcatgagg 194581 cggaggatat tgcacaggaa gctttcatca gagcgtacgt taatatcgac agttttgata 194641 ttaaccggaa attttcaact tggctttatc gaatcgcgac caatttgacc attgaccgca 194701 ttcgcaaaaa gaagccggat tattacctcg acgcagaggt ggctggtacg gaaggcttga 194761 ccatgtattc tcaaatcgtc gcagatggtg ttttgcctga agatgcagtt gtatcgctgg 194821 agctctcaaa cacgatacag cagaaaattt taaagcttcc tgacaaatac agaacagtca 194881 tcgtattaaa gtatattgac gaactctcat taattgaaat cggggagatt ctaaacattc 194941 ctgtggggac tgtgaaaacg cggattcaca gaggcagaga ggctcttaga aaacaattaa 195001 gggatcttta agtggggtga tgaaatgagc tgtcctgaac aaattgtgca gcttatgcat 195061 atgcatcttg atggagatat ccttccaaaa gatgaacacg tattaaatga acatctggag 195121 acatgcgaga aatgcagaaa gcatttttac gagatggaga aatccatagc gctcgtacgg 195181 agcacatcgc atgtcgaagc ccccgcggat tttaccgcta atgtcatggc aaaattgcct 195241 aaggagaaga aaagagcttc tgtaaaaaga tggttcagaa cccatcccgt tatcgcagct 195301 gctgcggtat tcatcatttt gatgggcggg ggttttttta acagctggca taatgaccac 195361 aatttcagcg tgtccaagca gccgaatctt gtggttcata accatactgt gaccgtgcca 195421 gaaggtgaga cggtcaaagg tgatgtcact gtcaaaaacg gcaagctgat tattaaaggc 195481 aaaatagacg gggatgtaac cgtcgtaaac ggcgaaaagt atatggcctc tgctggacaa 195541 gtcaccggtc agattgaaga aatcaatcag ttattcgact ggacatggta caagatgaag 195601 tctgcgggga aaagtgtact cgatgcattc aatccgaacg gagaagagta aagcgcgtta 195661 gccgctttgc tctttttttg cgggctgaga gggctggcac atttcacttg ctaaatcgaa 195721 atgtggtata atgggctcgc tatgtaaagt acatatgcgt aacacgtaaa acacaaaata 195781 cgaaatgact gaaatcttgg aggacgagga aatggctttt gaggatatcc cttttttgca 195841 gtacctcggc aatgccgttg atattctcct tgtttggtat gtgatatata aattgattat 195901 ggtgatacgc ggcacgaaag cggttcagct gttaaaagga attgtagtca tcgtgcttgt 195961 tcgtatggcc agccaatatt tgggcctcag cacacttcaa tggctgatgg accaagcgat 196021 aacatgggga tttttagcaa ttattattat ttttcagcct gagctgagaa gagcgcttga 196081 acagctaggc cgcggccgct ttttttcgag gagcggcacg cctgttgaag aagcgcagca 196141 gaaaacgatt gaggccatta caaaagcaat caattatatg gcgaaacgcc gtataggcgc 196201 cctgctgacc attgagcggg atactggaat gggcgattat attgagaccg gcataccact 196261 aaatgccaaa gtcagctctg agctgctgat caatattttt attccaaaca ccccgcttca 196321 tgacggtgcg gtaattatga aaaataatga aattgccgcg gccgcctgtt atctgccgct 196381 ttctgagagc ccgtttattt caaaagaact gggcacgcgg cacagagcag ctgtcggtat 196441 cagtgaagta acagacagtt tgacgattat tgtgtctgaa gagaccggcg gcgtcagtgt 196501 ggcaaagaac ggcgaccttc acagagagct tacagaagaa gcgctgaaag aaatgcttga 196561 agccgagttt aagaaaaaca ccagagacac ttcttctaac cgctggtatt ggaggggcaa 196621 gaaaaatgga taaattctta aacaaccgct gggctgtgaa aattattgct ctgcttttcg 196681 cgctcttgct ttatgtggcg gttaacagca accaagcacc gactccaaaa aaaccgggtg 196741 aatctttctt tccgacatca acaactgatg aagcaactct gactgatatt ccggttaaag 196801 cgtattatga tgatgaaaat tacgtcgtga cgggtgttcc gcaaacggtt aatgtcacga 196861 taaaaggctc gacaagcgcc gtgaaaaagg ctcggcagac caaaaacttt gaaatatatg 196921 ccgatatgga acatttgaaa accggcacac ataaggttga gcttaaggcc aaaaacgtgt 196981 cggatgggct gacaatctca attaatccgt ctgttacgac agtgaccatt caggaacgga 197041 cgaccaaaag ttttcccgta gaagtggagt actacaacaa aagcaagatg aaaaaaggct 197101 attctccgga gcagccgatt gtcagtccga aaaatgtgca gattaccgga tcgaaaaatg 197161 tgatcgataa tatttctctt gtaaaagctt cagtgaattt ggaaaacgca gatgaaacga 197221 ttgaaaagga agcgaaagtg actgtctatg ataaagacgg aaacgcgctt cctgtcgacg 197281 tggagccctc ggtcatcaag attaccgttc cggtgacaag cccgagtaaa aaagtgccct 197341 ttaaaattga acggacagga agccttcctg acggtgtcag catagcgaat attgaatcca 197401 gccccagtga ggtaacggtt tacggctcac aggatgtgtt ggattctctt gaatttattg 197461 acggcgtcag cctagattta agtaaaatta acaaggattc cgatatcgag gcagatattc 197521 cgcttcctga cggtgtcaaa aaaatctcac cgtcaaaggt gactttgcat atagaagtcg 197581 atagtgaagc ggatcagaag ttcgagaatg tccctatcaa gactgtaggg ctgagcagct 197641 cacaaaacat tgaatttctt gatcctgaat cacaagcgat agatgtaacg gctaaaggct 197701 ctcccacgaa tataaataaa ctgaaaaaat cagatattga attgtatgtg aatgtttcag 197761 atttagagga cggggagcat agcgtgaagc ttgaagtgaa cgggccacag aatgtaactt 197821 ggtccttggg gcggaaaaac gccaaaatca agctgacgtc taagaaaagc aatacatcaa 197881 cgaatgataa cagcagcaat acatcaggga accaggacac agataaacaa acaaatgatc 197941 aaaagaacaa tcagcaagaa gatacaaaga acactgataa aaacaacaac gatcaaaacc 198001 aagacggaaa taaagatcaa aaccaagatc aggatgagga tgaatccact gcgaattcac 198061 aatcctcatc ggaataaaaa aggagcgatt ataaaatggg caagtatttt ggaacagacg 198121 gtgtaagagg tgtcgccaat agtgagctta cacctgagct ggcctttaaa gtcggacgtt 198181 tcggcggtta tgtgctgaca aaagacaaac aacgtccaaa agtgctgata ggccgcgata 198241 cacgcatctc cggccatatg ctggagggag cccttgtcgc cggactttta tccattggcg 198301 cagaagtcat gcgcctgggt gtcatttcta caccaggtgt atcttatttg acaaaagcga 198361 tggatgcaga ggcgggcgtc atgatttccg cttctcataa cccagtgcag gataacggca 198421 tcaaattctt tgggggagat ggatttaagc tttctgatga acaggaggct gaaattgagc 198481 gcctgatgga cgaacctgag gataagctgc caagacctgt cggagcagac cttggacttg 198541 taaacgatta ttttgaaggc ggacaaaaat atctgcaatt cttaaaacag acagctgatg 198601 aagatttcac aggcattcat gtggcattgg actgtgccaa tggcgcaacg tcatccttgg 198661 cgacacacct gtttgctgat ttagatgcag atgtttctac aatggggact tccccgaacg 198721 gattaaacat taatgacggc gtcggttcga ctcatcccga agcgctcagc gcgtttgtca 198781 aagagaaaaa cgcggatctc ggtcttgcgt tcgacggtga cggcgaccgc ctgattgctg 198841 tcgatgaaaa aggaaatatt gtagacggcg accaaatcat gtacatatgc tcaaaacatc 198901 tgaaatcaga gggccgttta aaggatgata cagtggtttc aaccgtgatg agcaacctcg 198961 gcttctataa ggcgctcgaa aaagaaggca tcaaaagcgt gcagacagct gtcggcgacc 199021 gctacgtagt agaagcaatg aaaaaagacg gctacaacgt cggcggagag cagtcaggac 199081 atcttatttt ccttgattac aacacgacag gggacggatt attgtctgct attatgctga 199141 tgaacacttt aaaagcaaca ggcaagccgc tgtcagagct tgcagctgaa atgcagaagt 199201 tcccgcagct gttagtcaat gtgagagtga ctgataaata taaagttgaa gaaaatgaaa 199261 aagtaaaagc agttatttct gaagttgaaa aagaaatgaa cggcgacggc cggattttgg 199321 tgcgcccttc aggaactgaa ccgctcgtcc gtgtcatggc tgaagcgaag acgaaagagc 199381 tgtgcgatga gtatgtcaat cgcattgttg aagtcgtccg gtcagaaatg ggattagagt 199441 aacgaagtct attatcagag agtgaacaag acaagcgagg tttacataag ataattgtga 199501 gacatacggc aaagttgctt aaaaaacaat tgaccgttta tgccacatgt tgtaaaatca 199561 agcttgtctt gttcttattt tctcaatagg aaaagaagac gggattattg ctttacctat 199621 aattatagcg cccgaactaa gcgcccggaa aaaggcttag ttgacgagga tggaggttat 199681 cgaattttcg gcggatgcct cccggctgag tgtgcagatc acagccgtaa ggatttcttc 199741 aaaccaaggg ggtgactcct tgaacaaaga gaaatcacat gatcttccaa aaaacatgta 199801 ggaggggacg attgaaagtc cccttgaaat ttgactttct tcgtctcctt ttacaatctt 199861 aggaggaaga aaaatatgtg tggaatcgta ggttatatcg gtcagcttga tgcgaaggaa 199921 attttattaa aagggttaga gaagcttgag tatcgcggtt atgactctgc tggtattgct 199981 gttgccaacg aacagggaat ccatgtgttc aaagaaaaag gacgcattgc agatcttcgt 200041 gaagttgtgg atgccaatgt agaagcgaaa gccggaattg ggcatactcg ctgggcgaca 200101 cacggcgaac caagctatct gaacgctcac ccgcatcaaa gcgcactggg ccgctttaca 200161 cttgttcaca acggcgtgat cgagaactat gttcagctga agcaagagta tttgcaagat 200221 gtagagctca aaagtgacac cgatacagaa gtagtcgttc aagtaatcga gcaattcgtc 200281 aatggaggac ttgagacaga agaagcgttc cgcaaaacac ttacactgtt aaaaggctct 200341 tatgcaattg ctttattcga taacgacaac agagaaacga tttttgtagc gaaaaacaaa 200401 agccctctat tagtaggtct tggagataca ttcaacgtcg tagcatctga tgcgatggcg 200461 atgcttcaag taaccaacga atacgtagag ctgatggata aagaaatggt tatcgtcact 200521 gatgaccaag ttgtcatcaa aaaccttgat ggtgacgtga ttacacgtgc gtcttatatt 200581 gctgagcttg atgccagtga tatcgaaaaa ggcacgtacc ctcactacat gttgaaagaa 200641 acggatgagc agcctgttgt tatgcgcaaa atcatccaaa cgtatcaaga tgaaaacggc 200701 aagctgtctg tgcctggcga tatcgctgcc gctgtagcgg aagcggaccg catctatatc 200761 attggctgcg gaacaagcta ccatgcagga cttgtcggta aacaatatat tgaaatgtgg 200821 gcaaacgtgc cggttgaagt gcatgtagcg agtgaattct cctacaacat gccgcttctg 200881 tctaagaaac cgctcttcat tttcctttct caaagcggag aaacagcaga cagccgcgcg 200941 gtactcgttc aagtcaaagc gctcggacac aaagccctga caatcacaaa cgtacctgga 201001 tcaacgcttt ctcgtgaagc tgactataca ttgctgcttc atgcaggccc tgagatcgct 201061 gttgcgtcaa cgaaagcata cactgcacaa atcgcagttc tggcggttct tgcttctgtg 201121 gctgctgaca aaaatggcat caatatcgga tttgacctcg tcaaagaact cggtatcgct 201181 gcaaacgcaa tggaagctct atgcgaccag aaagacgaaa tggaaatgat cgctcgtgaa 201241 tacctgactg tatccagaaa tgctttcttc atcggacgcg gccttgacta cttcgtatgt 201301 gtcgaaggcg cactgaagct gaaagagatt tcttacatcc aggcagaagg ttttgccggc 201361 ggtgagctaa agcacggaac gattgccttg atcgaacaag gaacaccagt attcgcactg 201421 gcaactcaag agcatgtaaa cctaagcatc cgcggaaacg tcaaagaagt tgctgctcgc 201481 ggagcaaaca catgcatcat ctcactgaaa ggcctagacg atgcggatga cagattcgta 201541 ttgccggaag taaacccagc gcttgctccg ttggtatctg ttgttccatt gcagctgatc 201601 gcttactatg ctgcactgca tcgcggctgt gatgtggata aacctcgtaa ccttgcgaag 201661 agtgttactg tggagtaata attaattaac ccctttggat aagaaggtct tcacatgtgc 201721 tgctaggctc caaatgtaca cctttccgta agggcaaagt caaatgtgaa aaaaaactgt 201781 tccaaagtta atcagaaatt tattttcata ttgtatcctt cggtatcaag tgaaaggagc 201841 atcatatgaa aacattatgg aaagtcctca aaattgtttt tgtcagcttg gctgctttgg 201901 ttttgcttgt atccgtctcg gtatttattt atcaccattt ccagctaaat aaggaggcgg 201961 cactgctgaa aggtaaaggc acagtagtcg atgttgacgg taaaaagatg aatgtgtatc 202021 aagagggaag cgggaaggat acgtttgtgt ttatgtccgg ttcgggtatt gctgcgcctg 202081 cttatgaaat gaaggggctg tacagcaagt tttcaaaaga aaataagatt gctgttgtag 202141 atcgggcagg ttatggatac agtgaagtgt ctcacgatga cagagatatt gatacggtat 202201 tggaacagac gaggaaagcg cttatgaaaa gcggaaataa gcctccttat attttaatgc 202261 ctcattcgat atccgggatt gaagcgatgt attgggcaca gaaatatcct aaggaaatca 202321 aggccattat tgcgatggat attggattgc cccagcagta cgtcacgtat aaattgagcg 202381 gagttgaccg attgaaagtg agagggttcc acctgttaac ctcgattggt tttcatcggt 202441 ttataccttc cgctgtatat aatcctgagg tgattcgaca gtcgttttta actgatgaag 202501 aaaaagaaat ctataaagcc attaacttta agcaattttt taatgcagat atggagcatg 202561 agcttttaca gtcttaccaa aacggcagca aatctgtgaa tctgcctgcg ccaaaggaaa 202621 ctcccgtctt gattttagat gcagtctctg accaaaatag acattcaaag tatgctatac 202681 aaaaccgaaa agactatgaa gcgtttgcgg ctcaattcaa tactgccgat ataaaggaac 202741 tgaggggaac acacagtatt tatttatatc agcctgatca aatatataaa ctgtccatgg 202801 agtttatgag aaaggttcgc taggatgaag ggttatcgta ttttaatcgt tgaggacgat 202861 gtgatgattg gtgatttgct gcaaaagatt ttgcagcgcg agggatatcg tgtgatatgg 202921 aaaacagatg gagcggatgt gctttcggtg attcagaagg tggatttggt cattatggat 202981 gtgatgctgc cgggtgaaga cgggtatcaa atgtctgcaa aaatcaaaaa gctggggctg 203041 ggcattccgg ttatttttct ctcagcccgc aatgacatgg acagcaagct tcaaggtttg 203101 cagatcggcg aggattatat ggtaaagccc tttgatccga gagagctgct attaagaatg 203161 cggaatatgc ttgagcatca ttatgggacc tttacgcaaa tcaaacattt gtatattgat 203221 gcggtaacga aaaaagtgtt caatgaaagc ctgcatgatg aggtattatt tactgcgatt 203281 gagcggaaaa ttttctttta tttatatgaa aatagagaca gtatcctgac aaaggaacat 203341 ttctttgaat atctatggca gctcgaagat agaaacccga atattgtcaa tgtgcatatt 203401 aaaaaaatta gagctaaaat caatgatcaa gcgggtgaga tgattgaaaa tatatatgga 203461 gaagggtatc ggctgaatac cgttgtgaag aaatgaagct caagacaaaa tatcagttgt 203521 tattgtttac ggccgtcatt agtgttccga tgctattgct ggcggtcagt gttttgatgt 203581 cggtgattta tgacagcatg tttaaaccga tgaatcatgg tatgcccttt cacaggtcgt 203641 ttgcataccc ggcaatgatc gttgtatttt tgatatcact cttattgtta gcttttttat 203701 tttcaaagtc gattcattct ctgttgcata aaatcaatct attaaatcaa accattcggc 203761 atttggcgag tgatcaaagg gtgcccgata aaattgaagt gaagcgtgct gatgaaatcg 203821 gggaactgat caagtcggtc aatttgttaa ttgaacggac gacatatcgt gaactggagc 203881 tgagacagca ggaggaaatc aaaaaggagc ttttgcaaaa actgcggcat gacattaata 203941 cacctttaac ggctctcagg ctgcagttat tttatttgga agaccaatgt catggtcagg 204001 ctgtattcga atcattgtat cagcaaatcg aatatatctc ggaattaact aatgaattca 204061 atctatattc cgctgagacg ctggaaagct cttatattgt aaatgaagaa gtgcgtctaa 204121 acgagctatt agaaacagcg gtgaaaaagt gggattattt atacagtatg agtgggattg 204181 agctgcacta taagccggca gatcaagatg tgatatggat gagcaacacg ttatggatgg 204241 aaaggctgtt tgataatatt tttcaaaata cgttaaggca ttcaaaagct aaaaagatgg 204301 aagtcacgat tgaacatggc gatgttttta ttcgtgatga cggtattgga tttgatcgga 204361 atgagagcag tgagggactt gggttaaaga ttattgagga tacatgcagg ctgcttgcga 204421 ttacttatga gctgcataca aatgataacg gaacggggtt cttgttttca aaagagtgac 204481 cccgctgatg tttttctttc tcctataaaa tttatataat agggagaaag aaatggggtg 204541 aacatcatat gtttaaaaaa atcatcaaaa cgattaagta cctctcaagc agttctagtg 204601 accgatatcg cagacaccgg cattacagca gcagccggcg cagacattat cgcagctaca 204661 gcagcagttc gggcaaaaga agacactacg accgttatgg cggcagtcat cgttacaaac 204721 gccggagcta cagcagcagt taatccaaaa aaagttcttg ttccgctttt gggacaaggg 204781 tttttttatg tgaccgattg aatggcccgg tttagatcct cgcgaatgga agcggtgtgc 204841 tgatactctt cctcaatgcc caataatctt ttcagcagca aggttacttc ctttgtcagt 204901 gttaattcct ccagccaagt gccgtttttc ttcttttttc ctttatattg agagtacagc 204961 aagaataaca gcgtttctcc gagatcgaag aagtcatcct gttttcgtac ctttatttcc 205021 tccatttctt caggagtcaa ttgtttggca aggccgaaat cgatgaggca gagcctgcca 205081 tcattgatga tgatattagg cgttctgatg tcgctgtgga agataaggcg atcatgcagg 205141 tattctataa tctcaagcag ctgcgaaatc agttgtaacg ccataagctc tgtgaacggc 205201 tgttttcgaa aaaataataa ttcttctata ttctctccct caatgaactg catgacataa 205261 taagcctgtc cgtctatgat gaattcatct atgaagcccg gaatttgcgg gtggtgaatg 205321 tttttgagca gttttatttc ctgctggaat cggactttct ctttttcctt tttggctttt 205381 gtcggccgaa gctgttttaa gacataaggt gtttgagcta ggatatcggt gcacaaataa 205441 accaaaccgt agcctcccat accgaggcac tcttcgattt tgtattgatg atttaagata 205501 acgccgttct ttagagggcg gtcaaatagc agttttttta gaagttttaa tgccatgtct 205561 gcacttccct tggttgtact gactatagtt taccttctag acggagaata aaaaagagcc 205621 ggataaccgg ctcggtataa gttaaaactg ctttgtcacg tcgtattcat aatctatttt 205681 tgcttttacg ttgctcatcg tcgatctggc tgtcgctaat gtattatatt taaaactcca 205741 tacctttgcc acactgagtt gatccgacaa agagatatca taagaccctg aagtcgagct 205801 gtttacaagg gcacggctcc attcgttatt ttcgcttgtc atgatcagat ggcgtgtatt 205861 tccctggctt ggtgtttgag tggcggttgt ttgaactctg gttacaatgg catcacgcgg 205921 tatcccagat tggtttgtta aatcaacctt gatcacgctg gagtcagaac ctgaggggct 205981 aaggcttgta tttcctttat tttcagcaac gccgctgaat tggaacgttc cgctgcctga 206041 tttgattcgg tcttcaattg aaagcgtaaa gtacatgttt ccagtatagg tgcctcgtga 206101 cactttcaca tagaaggtat ccgtcgtgtt ttgggcgtct gcatttgcat aaataaaaga 206161 agaaaacgta ttagggttaa taacttctgt cccttgagaa acaggtattc tgttcttgtc 206221 ataaatttca attttcatcc ctgtatacgc gctctggtat gtactcctca tgtatacttt 206281 ttctccctta ttagccgtaa aagtgaaata ggcttcatct tgaccagctt ccagtattgt 206341 tgtatcgata tttttatatt tccaataacc gatcggcatt gcggtatcaa atgaattgtt 206401 tcctgtgata gcagtgactc cgacagctga tgccgaatac gtaaaggtag ataagacaga 206461 aagcataaca gcgaattgaa taagccattt tttcaccatg caaacaacct ccttttattt 206521 ccatcataca taataacgat ttaggtgtaa ataaatgttt tttgaggtta atatatacat 206581 tatattcgcc gataaaaaag aataagagag aatactcggg agggaattca atgcgtctga 206641 atcggcaatt tatccgcact cagctgattg cacagaacat attgagcaag aatgcgcctg 206701 ccaaacggga gaatgcgact gaaaatccag cggcagttct ggaaaaggca tatagcaggc 206761 ttaagtcaca atcttcaact gggggaatca atcagttcaa ttattctaaa accagcgtgt 206821 cgggaaacag cgggacgttc agcaaagtgt atcaatcagc gaatgatcga acagtgacag 206881 acacagggga agaaacagtg attcaatccc aaaaccccta tgaatctgag agtgatatca 206941 gaatcaaaat actagatgaa aaatacagca ggatgaatgc gattaataaa acaaagtctg 207001 atccattagg ctatattaag gataagtacc aaaattcaaa gtctccttat ttcagaagtg 207061 atctgtcagc tgcagaaaga caggccgctt acgataatga aacagaatgg ttattcaaag 207121 ggaaggcgca aaactataac cttcaggatg ctgtgtttcg gaatgtcaca tttcatgggg 207181 aagtggaagc tgagaatgaa aaggtgtatc agcggggaca ggttaaccag cagctgcaag 207241 tactgttgaa tcgaaaccat attcatattc cagaggggac agagctgacg tttacaatca 207301 caccgattga ctatcaggtg cgggtaagcg ggacagacga tcaggatctg atcaagcaaa 207361 ttgagcaagt gctgcaatct ggagacaaca gcaaagaact atttttacac atcatgaaaa 207421 gtcaaagcag tgattcagca caattttccg aagaggccta taaaaagtat caggcagctc 207481 gtgagatgta tgaagttaca ggctaccatt tgaaggattt agaagtgatt gatgggcggt 207541 acgtcacgcc tgagggacgt gacttaatgg atgtatataa ggaagagctt gaaaaagatc 207601 cagtgcagaa acaaacggct tcttatgcta tatcttacta tcgttcagag ctcagtaaaa 207661 tcgcggaagc cgggtataat gccattccgg atttcatcct atcaattgat tacagcaatg 207721 gatctctgag agatgtggga caaagcaaga gctatgggac cggagatacc gggtggcttg 207781 aagcattaaa gcgtcaaacg ggtgtgaatt attaggtaag ctgttcatgt aggacagctt 207841 attttttatg agaatctaag gggtgaatta atcccaatat tcaaataatt ttattatttt 207901 tatataaaag attttaaaag aagtgaacga ttcaaaactc tgaacaaagg tgtttacctg 207961 aaaaaaacaa ttgtattttc cagagaaatt tattatgatg aaataagtaa tttaggagat 208021 tatataacaa ttttaagttt gaattttctg attgttatca ctgattcatg tgaaggcaag 208081 caggtctgct gttttctcat ttatgagtat tttgttagga ggaggaagag gagtggcaaa 208141 taaagaatta aagaggggcc tgggcgcgcg ccatattcag atgatcgcct tgggcggtac 208201 aatcggtgtt ggcttgttta tgggttctgc cagcacgatt tcatggactg gcccatctgt 208261 ccttctggct tatgcaatat gcggaatttt tatctttttt attatgcgtg cgatgggtga 208321 aatgctgtat gtcgagccga gcacaggttc ttttgcgacg ttcggccatc aatatattca 208381 tccgatggca ggttatataa cagcatggag caactggttc cagtggatta tcgtcggcat 208441 gtcagaaatt atcgctgtcg gttcttatac gaagtattgg ttcccggatt tgcctgcttg 208501 gatacctggt atcgtggcaa tggtgattct tggtgcggcg aatttaattt ctgttaagtc 208561 gtttggggaa tttgagtttt ggtttgcgat gattaaaatc gtgacgatta tcttgatgat 208621 tattgcggga atcggaatta ttttcttcgg ttttggcaat ggcggagatg cgatcggttt 208681 gtcgaacctg tggtctcacg ggggcttctt tgcaggaggt ttctcaggtt tcttctttgc 208741 actgtctctt gtcattgcag cctatcaagg agttgagctg atcgggatta cagcgggtga 208801 agcgaaggac ccgcaaaaca cgctaagaaa tgcgattcaa agtattatct ggcgtatttt 208861 gattttctac attggcgcta tttttgtgat cgtgacggtg tatccttggg atgagctcaa 208921 ctcactcgga agtccgtttg tgtctacgtt ctcgaaaatt ggaattacgg cagcggccgg 208981 cattattaac tttgtcgtga ttactgcggc aatgtccggc tgtaacagcg gtattttcag 209041 cgcgggccgc atgctgtata cactgggtgt caatggacaa gcaccgaaat tctttaagaa 209101 gatttcacgc aatggtgtgc cgctgtatgg cacaattgcg gtgctgatcg gtttggctgt 209161 cggcgttgta ctgaactata tcgcgccgcc gaagatcttt gtctatgtat acagcgcaag 209221 cgtgctccca gggatgattc cttggtttat cattttgatc agccatatcg gattcagaaa 209281 agcgaagggt gctgcattag ataaacatcc attcaaaatg ccgtttgctc cttttacaaa 209341 ctatttgacg attgctttct tgctgatggt tctggttggc atgtggttta acgatgatac 209401 tcgtatctcc ctgattgtag gcgtgatttt cttagcgctt gtggtcatta gttattatgt 209461 gtttgggatt ggcaaacgca cgcaggccaa tttgacaaaa agcgaacaag cagctgaata 209521 acgataaaaa agagacattc acggatgtct ctttttttat ttttcgcgta tggattttcc 209581 ctattttagc aagctatagg gtaaagatag cagaaggaaa ggtgttcata aaatggatgt 209641 tacactcggt tatttgcgcg aatcactttc gaatcatcta gaaaatgaag tctgccagcg 209701 tatttgcaag aagatgctgg cgaagcgtta tgcaaatgaa gaggaatttg taaaagactt 209761 agatgataat gaaatgtctt ttttgaacca tgtattagaa aaagaaatta agtatgccca 209821 gaatgaacag gatcaaaaac gggccaagga attaaacgag gtgtatgaat tactgctttg 209881 agaaaggcgg gtaagaaatg ggagcaattg aacgaagcgg atatacattt cagccggagt 209941 ttagcgttgt ccgtcaaaac ggagccatcc atgtgtacca tcaaggagaa tttgtggaag 210001 aaatcgaatt tgaatttaac ggggaatatc ccgatcatga tttgattgaa gagcttgtga 210061 atcattattg ttttgagcat gagatttaga gccctgccgt gcagggctct tttatttagg 210121 atgtaatcag gccatacttt ttcaggatat ccacggtgat gtttttggct tttgtgccgg 210181 aatcatcgac attggtgaca aagacataag agccatgctc tgttttgatg aatccgacaa 210241 accatcctaa tcccatatca gtcaggcggg ttccggtttt cccgtagagc gtgtaatgat 210301 cgccttcctc ttgaatcatc atgcgcttga cgattttcat caccggcttg tcaaatggaa 210361 gctcctcttt agccagtttc tccaaaaaag tttcttgttc cagcggagat attgtgagcg 210421 agctttgcag ccaaaactgg tcgattcccc cgctgatatc ctcgttgccg taagatagag 210481 tatgaagcca tgttttcatt ctttcctcgc cgatatctct cgctaatgcc tgataatacc 210541 agattgcgga ttcgcgcatg gccgagccaa gcgtatggtc gcggttccat gattcgaatt 210601 cacgcttgac cccgtcccat cgtttaacat cgtattcatc tcttacagct ttgacctgca 210661 aaccgattaa agcgttcacg actttaaagg tggattgcgg agtttgtctt tgatttgccc 210721 gttttctgtt atagacaaat gtctgatcct tttgtaaatc gtgaagaatg aaggttccat 210781 ccgtatcctt gaattcatca tcgacattca ttttgctgac attcaagtgt ttttcatgag 210841 cagatgatgc tgcgtggacg gagaagccgc cgatccctgc aatactcagc acaagcacaa 210901 catatatcca ttttttcatt ttgttctccc cttcgttttg attaactacc ttttctctct 210961 ttcgtttgtt cttcctttaa aaaataatca aaaagcgctt aaatttggtt ttgcaaacaa 211021 atactgttac tgggtttata gtcggaagat aacgtgaaaa tagagggtaa aaaggaaggc 211081 agggtaagcg gatgaatgag cagattccac atgacaaaag tctcgataac agtctgacac 211141 tgctgaagga agggtattta tttattaaaa acagaacaga gcgctacaat tcagatctgt 211201 ttcaggcccg tttgttggga aaaaacttta tttgcatgac tggcgctgag gcggcgaagg 211261 tgttttatga tacggatcga ttccagcggc agaacgcttt gcctaagcgg gtgcagaaat 211321 cgctgtttgg tgttaatgcg attcagggaa tggatggcag cgcgcatatc catcggaaga 211381 tgctttttct gtcattgatg acaccgccgc atcaaaaacg tttggctgag ttgatgacag 211441 aggagtggaa agcagcagtc acaagatggg agaaggcaga tgaggttgtg ttatttgaag 211501 aagcaaaaga aatcctgtgc cgggtagcgt gctattgggc aggtgttccg ttgaaggaaa 211561 cggaagtcaa agagagagcg gatgacttca ttgacatggt cgacgcgttc ggtgctgtgg 211621 gaccgcggca ttggaaagga agaagagcaa ggccgcgtgc ggaagagtgg attgaagtca 211681 tgattgaaga tgctcgtgcc ggcttgctga aaacgacttc cggaacagcg ctgcatgaaa 211741 tggcttttca cacacaagaa gatggaagcc agctggattc ccgcatggca gccattgagc 211801 tgattaatgt actgcggcct attgtcgcca tttcttactt tctggtgttt tcagctttgg 211861 cgcttcatga gcatccgaag tataaggaat ggctgcggtc tggaaacagc cgggaaagag 211921 aaatgtttgt gcaggaggtc cgcagatatt atccgttcgg cccgttttta ggggcgcttg 211981 tcaaaaaaga ttttgtatgg aataactgtg agtttaagaa gggcacatcg gtgctgcttg 212041 atttatatgg aacgaaccac gaccctcgtc tatgggatca tcccgatgaa ttccggccgg 212101 aacgatttgc ggagcgggaa gaaaatctgt ttgatatgat tcctcaaggc ggggggcacg 212161 ccgagaaagg ccaccgctgt ccaggggaag gcattacaat tgaagtcatg aaagcgagcc 212221 tggatttcct cgtccatcag attgaatacg atgttccgga acaatcactg cattacagtc 212281 tcgccagaat gccatcattg cctgaaagcg gcttcgtaat gagcggaatc agacgaaaaa 212341 gttaaattaa aaagctctct tcctttatcg aagagagctt tttgattact tctttttttc 212401 atcgtagtat tggacgggat acatggagcc ttctgatacc attttgttgt cctcgatatc 212461 ttgcgggtcc gggtggccgg ctttatcaac tgggaacgtt tccatgtctg gctgttttgt 212521 tattttcatc ttcatgctgt gaatgaattc tcttgccttt tggcgatttg acgggtcttt 212581 taatagataa gaagtgatgc cgacagttga aacagcgaga cctgaaagta acagcttttg 212641 tttcatggtg atactccttt ctattttaag aatagtgttt cctgtatcat tcccgttttg 212701 gaaattgcta aacctgttgt gtttttatca ttggaattaa cagtaaattc catttaagaa 212761 gaaactagtg acttcattcc tgtattggaa ggtaatatac attgacttat tatagatttc 212821 agtcaaaatt cgataaatat tgacaaagta aagtaatcag aataataata taattagcaa 212881 gagaatgtca tcatacatga aaggtgttta cgatatgaat caattgcatc gaagaatggg 212941 aacgttttcc ctcatgatgg tcgggctcgg gtcgatgatc ggttcaggct ggctgttcgg 213001 ggcttggcgt gcggctcaaa tagcaggacc agctgctatt atttcatggg ttattggaat 213061 ggtcgtcatt ttatttattg ctctttctta tagtgaacta ggttctatgt tccctgaagc 213121 ggggggaatg gtcaaataca cgcaatattc acacggttcg tttatcggtt ttattgcggg 213181 ctgggccaac tggattgcga ttgtgtccgt cattccggtt gaagcggtgg cctccgttca 213241 atatatgagt tcttggcctt gggaatgggc gaaatggaca agcggtttgg tgaagaatgg 213301 aacgctgact ggggaaggac tagcgtttgc ctctgtattg cttctcattt attttctgct 213361 gaactactgg acagtcaatc tattttcgaa agcgaattca ttaattacga tttttaaaat 213421 tattattccg ggtcttacga ttggagcttt gctgtttgtc ggattccacg gagaaaactt 213481 tactggcggt caaagcattg cgccgaatgg ctgggcaagt gtgctgacgg cggttgccac 213541 ttccggtatc gtttttgcgt ttaatggttt ccaaagcccg attaatatgg cgggtgaagc 213601 aaaaaatccg gggaaatcaa tcccgattgc ggttgttggc tctctttttg ttgcgacagt 213661 gatttatgtc ctgctgcaga tcgccttcat tggagctgtg aatccttctg atattgctca 213721 cggctggagc catctgaatt ttaattctcc ttttgctgat ctggcgattg cgctgaatat 213781 taactggctt gttattgtgt tatatgcaga tgcatttgta tcaccgtctg gaacggggat 213841 tacgtatacg gcgacaacgt cccgaatgat ttacggaatg gaaaaaaaca aatacatgcc 213901 gagtatattc gggaagcttc atccgattta cggcgttccg cgacaagcaa tgttctttaa 213961 cttgattgtt tcgttcatct ttttgttcct gttcagagga tggggcgtat tagcggaaat 214021 tatttctgtt gctacgttaa tttcttatat caccggcccg atcacagtga tgacattgag 214081 acggacgggg aaagacctgt acaggcctct tcgtttaaaa ggcttaaatg tgattgctcc 214141 gcttggattt atctttgcgt cactggtgct gtattgggcg cgctggccgt taacaggaca 214201 ggttctgttt attatcctga tcggtcttcc gatttatttc tattatcagg cgaaggcgaa 214261 atggaaaggg tttggccgga actttaaagc cggcgtctgg atggtgtttt atctgctggc 214321 catgatggtt atttcttatt tgggcagtga taaattcggc ggcctgaatg tcattcatta 214381 tggctgggat atggttctga ttgcgatggt atcccttgta ttctatgtgt gggcgctgaa 214441 gagcggctac cagacagaat acttaaagga tgcgaaagag ataaattctc agctgcttaa 214501 tggacagtca gaagctgctg ccggaaaaga ataaaatata gaagaaaacc ttgcgatagt 214561 tgtcgcaagg ttttttgctt ttaataaccc ttttttactt tgtggaaaag atcaggatag 214621 ttggtgaaca ctcctgttac gccccaatca agcaggcgat gcatatcagc ttcattattg 214681 actgtgtaag gatgaagcag gaggccgtgg ctgcggatca tacggacgtt ttcttgattt 214741 aaagctttat aatccgggcc cgcaccgaca gcgtatgttt tgatttcttc cagggcagca 214801 tctgtcattg acgccatttg tttggcttcc agcaattgaa cggtcggcag gtttggctgt 214861 aattgatgga cttttaccag gctttctttg ctgaacgatt gaatgatcac ctggcctggc 214921 ttagaatgct ttcccagtaa tttatgtttc tgcaaagaag cgatcagttt ttcttccata 214981 cctgggtagg tgtcaggcga ttttgtttca atgtagtagt tcgcgtgctt tccgaaacgg 215041 tctaatacct cttctaatgt aggaacttta aggccgacgt actgcggctt tgctttttcc 215101 ggataggctt cattaaacca agaaccggcg tcaagcttct taatgtctgc gagcgtatgg 215161 tctttcaccc aacccattcc gtttgtggtg cggtccagtt tttcgtcatg catgacaatc 215221 aattttccgt cttttgtcat ttgcagatcc aattcaataa aatcagcttt cattttctga 215281 gcggtttcgt aagacagaat cgtgtgctca ggcacatatc cagaagcccc tctgtgcgcg 215341 acggtcagga tacggtcagg tgacagcagg tttccttttg acgctgccga cactggcgtt 215401 accataaatg agagtaagcc cagcgacaga acaaacaagg ccagtattct attttttctc 215461 atgatttctc ctccttatag ataagcacta cctgtctttc ataataaaaa acggatgtaa 215521 acggcgtgtt ggaaaactat taatctttta tgtgtctttc ttaaacatgc tctgcccgtt 215581 ttcctgtatt ccacgtcaaa gccaagaaga cgatggcaag aatgcaggat gagatcagca 215641 tgataaagcc gccgttccag ttaaaacggt ccacgacaaa gcccataatg gcgtttgcga 215701 aggcggatcc gccgatgtat ccgaaaaatc cggtcaaacc ggctgcagtt ccggctgctt 215761 ttttcggtgc taggtcaatt gcttgaaggc cgatcagcat aacaggtccg tagattaaga 215821 agccaatgct gatcagggcg atattgtcca cgagcggatt gccggccgga ttcagccagt 215881 acaccaatac ggcaatgaaa acacccgcca taaacaaaac gcctgccggt gcccggcggc 215941 ttttgaagaa tcggtcactg atccagccgc acaagatcgt tcccggtatg cctgcgtatt 216001 cgtaaagaaa atacgaccag cgtgagtctt caggagaaaa gcctttggct tctgttaagt 216061 aagtaggcgc ccagtcaacc acgccgtatc gcacgaaata aacaaataca ttggcaaaag 216121 cgatgtacca aagaaatttg ttgttcagca catattgaaa aagaatttct tttgttgtta 216181 attctttttc ctgattttta aaagcgtgtt ttggatagtc attccgatac tcttcaattg 216241 gcgggagtcc gcaggattga ggcgtatcac gaaccaataa aacaattaaa aatgaaatga 216301 taatggcgat gatggcaggg aagaaaaaca cgcttttcca agtgacgaac atcgcgatcc 216361 caagagtgac aagcggagca agaataccgc cgcctatgtt atgggcgaca ttccagatcg 216421 acatttttgt gccgcgttca cttatggaga accaatgggc catcgtcctg ccgcatggcg 216481 gccagcccat tccttgaaac catccgttga taaacataaa aataaacatg atggtgacgc 216541 tcgaagtcac ccaaggcatt gaaacgaata gaatattaac gattgctgat aaaaataggc 216601 ctgtcgccag aaaatatctc ggattacagc ggtcagacac cattcccatg atgaatttgc 216661 tgaagccgta cgcaatggac acagcggcca gcaccaaacc cagttctgtt ttcgaaaatc 216721 cctgttcctg cagataagga atggcaaagg caaagttttt ccgcagcagg tagtagcctg 216781 cgtagccaat gaaaatacca atgaatactt gcagtctgag ccgtttgtat gccgcatcca 216841 tctttgaatc atccagtctc tcaatatgag gagccggttt aaatatatta agcattaata 216901 attatccccc tttgctgttt gtgctggatg tgtggcgtgc ctcctttccc gaaaaacaaa 216961 aagagccaga aaacacccct tgtcaaaagg ggttggattc ctggctctcc tcatctccat 217021 ccaagctatt aacttatcat gatagcgctt tcttaaatta tcatagtccg gagcgaatgt 217081 aaacgggtaa ttttcaaatt gggccttagg gaagtgaata ttatcctttt actaaatgca 217141 attatatttt tttactagta acataaaaat ctggagggag gctgtttaaa gatggatgaa 217201 ttagatatcg cattctttat tttaccgtta ggaattatgc tgctatcgat tgtcgggacc 217261 tgtatttgta aaaacccgta tctgatgcca atgcttagtt tggtgatttc tcttgtgctc 217321 acctttacca tttttaatca atcatttttg ggatgggctg ttgtctatag cttggtttct 217381 ctggctttat cctatatcac attgattgtg gtaaggaaaa ggaaggaatc aggaaattaa 217441 aaagacctca ctttctaaca tatcgttgac taaagcaact atatgtgatt ataattgctt 217501 tagtcaacga tattagaaag tgggaattga tttgaaaaca agagaatcat ctgtcgggtt 217561 aaaattcaga aagttcaatc gattttatac aaacgtcctt ggtttcctta atgagcacat 217621 ttacgacagc ccgttttcct taacagaaac acggatttta tttgagattt ataatacgcc 217681 taattgtacg gcaaaagctc ttcaggataa gctggggctt gaccggggat atgtcagcag 217741 gattgtgaag cagtttgaaa aagaagattt gatttataaa cagaggagca aagatgacgc 217801 ccgccaccat tacatttttg tcacagaaac aggaaaaacg atttataaaa agctggagga 217861 gaaagccaac gaacaagtag aactgatgct gaaggtaatc aaccaaaagg agcagcacaa 217921 gcttgccgag gcgatggcag agattgaagc gatcctttca cagtcgcttt ctgccagagc 217981 atcagagata tcgattagag attattttct ttcggaggat cttcaactcc ttattgagaa 218041 acaaagacaa ttttacgcgg aggctcacgg ttgggatgac acgtttttag cttatcttca 218101 ggagacattt gacgctgaca tcgaaaaaat atggattgcg gaaagcggcg ggaaatttgc 218161 cggctctgtc gggttggtca agcacgatga aaagacagtc cagctcagat ggtttctggt 218221 tgatgcggat tttcggggca gggggcttgg cacgcaattg ctggagcatc tggttgcata 218281 ctgccaagac atgaagtttg accgcatttt cctttggacg gtgagcacga tggctgaggc 218341 tcgtccgctc tataaaaaat ttggattcag gataagtgaa gtaaaacaag aagcgccatt 218401 atggggacag cagctgacag aagaacggtg ggatttggag ctgtcatgaa aagactgcat 218461 tatgcgtgga tcatcgtctc cgtcaccttt ttgatcttat tggcggttca gggggtgcgg 218521 ctgtcgtttg gtgcgtttgt ggagccgtgg gaacggcagt tttcaatcga tagaagcacc 218581 atctcgctga tttcgacggt gagttttatt gtttatggca tatcacagcc tgtgatcggt 218641 cggcttgtgg acaaatgggg tgcccgggct gttttggcat ggagtgcgtt actgacagga 218701 gtcagcattt tcttaacata ccttgtgact tcgccttggc agctgttttt gctttacggg 218761 ctgggtgtct cgcttggagt gggcggagca tcgaatgtgg cggcaagtgt attggtcgtc 218821 aattggttca gcaaaaagcg gggactagcc tttgggatca tggaagcagg ctttggcgcg 218881 gggcaaatgc ttctcgttcc cggctcactc atgttgatcc attggtttag ctggaagctg 218941 acggttgtgg tgttgggact gctgttaatc gtgattgtct ttccggctgc gctgctgatg 219001 ctgcggaaca atccttcaga aaagaataca gagccgatag gcggactggc tgcatcagaa 219061 aaagaaacag cacccaaaac aacagctctt tcagtggccg ggatgtttcg tatgaggcaa 219121 ttctggttct tgatttttcc gtttttgatc tgtggattta cgaccgtggg gctgatggat 219181 acccatttga ttccgttttc tcatgatcat ggcttttcaa cgacagtcac gagtgctgct 219241 gtcagtctgc tagcaggctt taatattgct gggatcttgc tgtccggaat tgtagcggac 219301 cggtggagca gccggaaaat cctgtgcatt ttatatgcgg tgcgggcgct gtcgatcgtg 219361 attcttattt acagccacga gccctacttg cttttagcct ttgcgattct gtttggatta 219421 gtggactttg caacggtagc accgactcaa atgctcgcca cccagtactt tcaaaactac 219481 tcgatcggcc tcatgattgg ctggctgtca ctcgcccatc agatcggatc ggcactaggt 219541 gcgtatgtgc ccggcgtcat ctacacggta acgggtgagt atacactggc tttttatttg 219601 tcgattggaa tgctcgtgct tgcgagcgta atgaatgtga tgctgaggga gccagctgcg 219661 gttacgcgtg acagtgcggc tgtggtagac aagtgatgag gacaaaggga aagcatctct 219721 gatttcgaga ttattcagag atgctttttt tgtatttttg ttctaatacg aagtcgatca 219781 taccgactat gcgggcgttt tcggattttt gtttgaagcg ttcagaaatt tgaacttttc 219841 ttgaaaatgg ggaaacaata aaaacccaaa aaaggccgat caaggcaaaa aacatttgta 219901 cagctaattc tattaattca ttaaaacgag tgctgaaaaa atagaagtat aacgttatta 219961 atgtcacagt acatacgatt ttggcaagtg tgtttgaatg taagcaatgg ttcactaaag 220021 aataccttta attgattcag catgattgaa tcatatttgt ttaggaaaat aagaagttct 220081 ttatcatctt ttttatgttc taaaataaag ttgctgtttc tgtttcttta tatgtatggt 220141 ggtctacatt caatatatac atctcttaaa gtataaaaat tgagtatttc ttagtaagga 220201 tgaaacaaaa ttacatgatt tttttgttat atctttcagt tagaataaaa tctataactc 220261 ctctcattcg caaatattcg gctctctgtg caaagtgcag aacagtatgt aattgtcctt 220321 ttctagatat atttaaaagc tttatcaaat caataaggat tttcaagaaa ataattaata 220381 atagaaagat aaaaatgtgt ggtatgtcaa tgtaattgat ttgtcctgaa aataaagaag 220441 ttgcatagac aacaataata cttccgcaaa acatcaaact catataatgt ggaagggaaa 220501 atggacgagt tgaaaaatat gcttttaatt ggcttagcat agcattatct cttgtatcta 220561 agtagcccaa aagctcttta tcatttttac taattgtaag aacatgattc aatacagcac 220621 taaaattcat tgaatcttca ttatcagagg cagtatgttt attagcctgt atgttttgtt 220681 gatccatttt atatttttta taaagtattg tattaattaa cttgtttttc tcatagaatt 220741 cagatcgttg attaagggat gcttttcctt tgtttttatt tccttttttt atgattttag 220801 tataagtcat aaaaatacaa atgactgtaa aaatagaaaa cactgcaggt gaaatatctg 220861 aaagaatagt attggtgaag acttcttttg cttggatgaa aaggaaagaa gctaaagtca 220921 tagatataaa catgcataaa actgctactt tcacaagaaa ctgaagcgga agagaaggtt 220981 ccgaataata gtgcttcaac tggttgagtg tcagagaatc ttggcgaaaa agataatcta 221041 ttatctcctg ctgattttgc atctgattga tatcatgagc gatgtttttt gttttttcaa 221101 aaactatttg atcatttttc atttttgata aacctccaaa agacgataga taaactaaaa 221161 aaactgcatg agcatatttt aacttatgtt catgcagttt tgtattaaag ttagctagta 221221 taataagcaa aaatggccag taacatagca gataatgcgg tagcgacttt gactccttta 221281 ttgttcgtta aatcactgcc catattccca attagtaaaa gtgcagcaac acctacaaca 221341 gggaataaat attgatcata agacggccaa tctaacgcta attcactctc gggagacgta 221401 actggtactc ccttgtacgt ctttatttta aacgtaatcg tagtcgttag tccagttgtg 221461 acattgtcac cgactggaat atcaggtgta tagattttaa tttgaatgtt taaagattca 221521 gctgttggat ttacataaac ctccaaataa ccgttgcgta ctgataagct cagactattt 221581 aaaaggtttt gataagagtc gatttgtgac gcagtgagag acgtttgagt gtcgcccaat 221641 aaacccgtga tataggcacc tggtttacca tttgtaatgg taattgtgtt tggtgaacct 221701 tcacttggta tggttgccag aagtgaagtt gatagaataa tatccaactc aggtgatgtg 221761 aaaatggttt ctgtcgtatc aaattcaaac atcgcgtttg ccagacttgt tagattttct 221821 aaagctggaa tggtagataa aatgtctgtc agtgtacgca gtcttgcatc atataccgga 221881 tcagacggcg gatttacatt gcttgcacct gagtctcttc ctgaataccc gtctttatca 221941 atcccgatgc ttccagagcc gcttccgatg gttccttcat aaaattgatc aaaggcccag 222001 ttgtttggca tcggatagcc gagattgccg ctaaatcctg ttgacatatt tgccacaaaa 222061 ctatactttg tcagtcctgc ttcagatgta cggatacaaa tgtttcttgg tccgtaaacc 222121 cctatttcat acttaggtgc ggttgaaaat gtctgcattt ttgtaaatgc tgacttaatc 222181 tcttggaaat aaggaatgat tttatcggtc acttcataat cgtatgcatc aaaatcgaca 222241 gcgaaataaa tggtcgtgcc tgacggaaaa cctaatcttc tagcagcaga agcggcacta 222301 tatgcatctc ttgtgccttg gtctttgaca aaataagaag attcatagcc gccgtcttga 222361 taaattggga aaaccttcaa tccggcatca agaataactg caagctcttt agatgtcagg 222421 gctttagatg tgaggccgct gcttgtccgc acatttccgg tcaaatatct gccaaccgtt 222481 ttataaccgt tattccgcag tgtttgagct ttttctgcgg ttataattgt agcagtgtca 222541 caagcagaag cggtgcgagt tgtgtctcct gagcttgata ataaagcttt aatggttggc 222601 atatctgcat aacctgtttg cggcaggcac atgaactctt gaaatgcttt aacagctgaa 222661 acaacaccca caccatattt gccgtcaaac tcaccaggat cgaacgattt tccgttacaa 222721 tagagggcgt actgaacaat taagacaaat cctgttcttg aatcgccggg agttaaagta 222781 gggcacaaac ttgtggtgcc gtttccgaaa aatccattgg caacacttgt gctcatgcct 222841 tcttcttttt gcagggcata aataagagct ttatttgtat cgcggccata cagtccgtca 222901 caaggcatta acccgatata gtcattgtag tctcgattta agttttgttg aatctggcga 222961 attcttgaat cacccccaga caccagctta aaagcgctca tgtctaataa ggctttcata 223021 attaacgtgg tgacaatccc atcctgtgtt gtcagtccgg cagctttttg aaattctttt 223081 accgcatttt ctgttttttc gtaaaagacg cctgtaaaac cgccgggatt aaagccttta 223141 caccataaag ccccttgtaa aataaaattc atgttgcttg gttttgaatc tggagcttgg 223201 cgtttaagag gcttaaataa gcgctgtgtt gtcggcccga agttatcggc tggctctgag 223261 atacccaatt caatttgaag cgcccgagtc agaccgtaga tcgtatccca cccagttttc 223321 ccgctttctt caactgggtt atacccatgt ttgccgctgt acgtatcgtt cagccattgc 223381 tgtgtgatta agaccatttc atcaaccatt tcgattcctc ctttgttaga ttgcgttcat 223441 ttataggtgg caaacgtagg acaaaataaa aaaatggatg ccgttaagca tccattttac 223501 atccgttctc caacagcttc gctttcggtt tcagctctga aatgtagagg cctaaaagtg 223561 taagcgcgcc tcctagaaga gcgatccatg tcatgttttc gtgcagaatc aggacagaag 223621 cggcgatcgt gataaccggg accatgtaaa tatacgcact ggatttgacg gctccgagca 223681 ctccaactga ataattccaa gtggcgaagc acagggcaga agcgccaatc cctaagaaaa 223741 gcatgttgag tatatttgaa gcagatgaaa atcggcttag gtcaaaatgg aagtcgaaca 223801 aaaataaagc gggaaccata aacaataaac catacaaaaa tactctctgt gtcagctcga 223861 tgatgtggta ttcgtaggcg cttaattttt tcatgaatat cgagtatccg ccaaacacga 223921 gagcagcccc ggctgccatg atgtctccga gcggatttag acgcagtacc acattgccgt 223981 taaacgtaat caataaaagc ccgatcagtg ccgagataaa tccaatcaaa aaagtcagac 224041 gcaatttttc gccttcgagc agaaaatggg ccaaaaccgc agtgatcatc ggtataatgg 224101 acacgatcat gccgacattg gaggcgtatg tataggtgag agctatattt tctaatagaa 224161 agtataaggt tacgccaaat aaaccagctc cggcaaacaa cagctcctgc cgccaatttc 224221 tgaacggaat catgttggga cggacgagga taagagcgat aaagcccatc aaaaaccgat 224281 aaaataatat ttccattgga gagaagtcag ccagcagaac ttttgtcgaa ataaaggtcg 224341 tcccccaaat cagaatggtc acaatggctg cgatatgccc cgaagtttct ctttgtatgt 224401 tcatctgtga agctcctttt caaaaatctt catgtattgc ttcggcgtca gccccacctg 224461 ccgtttaaaa aacttcgtca tatgactctg atcgctgaat cctgtctgaa atgccgcatc 224521 aatcggcctt accccttgtt caaggagttt tttggcttga ttaatccgga ttgtttccat 224581 gtagctatta ggggtaatgc ctttttgttt tgtaaatgaa cgcaataaat gatacttgct 224641 ccagcctgtt aattcactca aatcattgag tgtaacattt tcggcataat gctcttctaa 224701 aaattcacaa accattttga cttcgtctga tggttctgga acgctgctaa ggaacgtgac 224761 atctgaataa tggcggatca gctcctctaa tagatgaaga aacagctcct ccttacgcaa 224821 agcttgtttt tcctcggata tcaaaatatg caattcctgc aggctggctg tcagctcatg 224881 gcggaataac acatgctggg agaaataagg gagatgcccg gagccagtaa tctctttcac 224941 cgccttctcc atgatatccg gcatgacatt gatacaccga taatcaagcg tccggccgtc 225001 aatctgttca cagctatgcg tgtcacgggg gttaaagagg agaagatcac ctggattgat 225061 gatatattct tgatcctgac aggccagata ccgttgccct ttttcaataa atccaatcac 225121 ataataatcg tgaaagtggt tcgggaactt ctgcataatt cccttgaagc ggtaggcttc 225181 tatatgaagg tgtgggtcaa gctgcagtgt gcgggtttcg ttttgcatgg gatgcctcct 225241 gtcggtgtgg tggtcttgga ttaagtgtag catgattttg ggggatttct tgtatgatgt 225301 tgctgtttag gaatagagaa agcagaccgt tatttgtctg ctttcgttta agaatttaaa 225361 agattttaac cctcaataat aattttatct tttttaataa aaatttattt ttcaaatatt 225421 tcagttataa tggtttggaa cagataggag gggcaaagat gtatcaatca aagaaggttt 225481 tattgttagg ttcaggtgaa ttaggtaaag aggtagtgat tgaagcccag cgtcttgggg 225541 tacagacggt ggcagttgac agttacgagc atgctccggc gatgcaggtc gcgcataaca 225601 gttatgtcgt tgatatgctg gacccagagc agatcagaac catcattgag aaagaaaatc 225661 cggatttgat tgtgcctgag gttgaggcga ttgcgacgga tgaattgctg aagcttgaag 225721 aggaaggatt tcacgttatc ccgaatgccc gtgcggccaa gctgacgatg gatcgggaag 225781 gcatcagacg acttgcggcg gaaacgcttg gacttgcgac agctggctat gaatttgcga 225841 atacatatga tgaatttata caagcggcag ctcagatcgg ttttccttgt gtcgttaaac 225901 cattgatgag ttcttctgga aaaggccaaa gtgtgtgccg ctctgaagcg gatttagaga 225961 gctgctggga gacggcgatg gaaggcggac gggtgaaaaa cggccgcgtg atcgttgagg 226021 agtttatccc tttcgaatca gaaatcacac tcttaaccgt acgtgcggtt aacggtacgg 226081 cattttgtga gccgatcggt catgtgcaaa aggacgggga ttatatcgaa tcgtggcagc 226141 cgcatgatat gacagagcag caaatagaag aagcgaagca tattgcgaaa acgatcacgg 226201 atgagcttgg cggatacggc ctgtttggtg ttgagctgtt ccttgcgaaa gatagggtat 226261 atttcagtga ggtatctcct cgtccgcatg atacgggtct tgtcacgctg gtgacgcaaa 226321 atttgtcaga atttgcgctg catgtccggg cgattctcgg ctttccgatt acagaaatca 226381 cacagctttc tcctggcgcc agcaggcccc tcaaagcgcc ggaagaatta gcggattaca 226441 ctgttgaagg attggaaaac gcactggcag tcccaaagac tcaagtgcgc gtctttggaa 226501 agccgataac aaaagccgga cgtcgtatgg cagttgcgct ttctgctgct gattcagttg 226561 aaacggcaag agagaatgca aagaaagcgt tggaccagct aattttaaaa tagagtttga 226621 acaggtcttg tcagatacaa gattcaatgc agtttgccgc ggttgaaagt ggtctgcgct 226681 tttaccaggc atatgatcaa agcctttctt tgtggccgat tgagtcggaa gcattctatg 226741 tttctactcg ttttggaaaa acacatatca ttgcaagtgg gccaaaggac gcaccttcgc 226801 tcattttgct tcacggaggc cttttcagct ctgcgatgtg gtatccgaat atcgcagcgt 226861 ggagcagtca atttcgtaca tatgcggtcg atataatagg agacaaaaat aaaagtatac 226921 catcagcagc catggaaacg agagctgatt ttgcagaatg gatgaaagat gtctttgatt 226981 ctcttggact tgagacggca catctggccg gcctttcgct tggcgggtcc catatcgtga 227041 atttcttact ccgcgcgcct gaaagagtag agcgggcggt tgttatcagt cccgctgaag 227101 cgtttatttc atttcatccg gatgtctata aatacgctgc agagcttaca ggggcaagag 227161 gagctgaatc atatatcaag tggatcacag gcgacagtta tgatctgcat cctttactgc 227221 aaagacaaat tgtggcgggc gtggaatggc aggatgagca aaggagcctg aagccgacag 227281 aaaacggctt tccgtacgtg ttcacagacc aggaattgaa atcaatacaa gtcccggtac 227341 ttctgatgtt cggtgagcac gaggctatgt accatcagca aatggccttt gagcgggctt 227401 cggtattggt gccgggaatt caggctgaaa tcgtaaagaa cgccggacat ctgttatctc 227461 tggagcagcc agagtacgtc aatcaacgcg tcttgtcctt tttatgcggg gggataaaat 227521 agtaaggaac atgaaaagat tggcattcat ttttcaaaag gtaacaaatg ttgtataata 227581 atagaatttg aatgctgctt tttttgggag cattctatgt tatcatgctt attggagaaa 227641 aatttttcct gtaacgctat tcgatcacta tcgtcaaata atatagatgg ttttacaatt 227701 ggaggtttgg ttacactgtg aattacatcc cctgtatgat tacgatagga aacttcattt 227761 gcggattgct ggcgattcat tccttgctat atcacaacat tcattcagca gtgcttttta 227821 tttttacagg catgttcctt gatttctttg acgggatggc tgctcgtaag ctgaatgccg 227881 tttctgatat ggggagagaa ctggattcgt ttgccgatct ggttacgttt ggggtggctc 227941 cttctatgct tgcttacagt gtcgcgttgt ataccctgcc atttatcggg atcttatgcg 228001 cattgacgta cagcatttgc ggaatgcttc gcctctctaa atttaacatt gaacaaagca 228061 agctcccgac gtttatcggt atgccgattc cgtttgcggg catgtgtctc gttattctaa 228121 gcttcaccta taacccgatc cttctggcaa tcggcacttg cggactctca tatttgatgg 228181 tgagtaaaat aaaattccct cattttaaaa aacatgcggc agaaaacctg gagtctggga 228241 gatggaatta gttcagcagc tcatagcgga ttacggttat ctcgctattt ttttgatgct 228301 ggtattagga attgtaggat tgccgattcc agatgaagtg atgatgaccg ttgttggcta 228361 tttcacgcat accgatgtat tgaattatga gctttcgata ttgattagtt ttgtcggggc 228421 tttgttaggt atgctgatca gctacatgat tggcagaaaa gccggacgcc cgtttatcga 228481 caagtacggc aagtgggtcg gcttaaaaga aaaaagaatg atgaaagtgg aaaaatggat 228541 gaagaaatac ggtccatatt ctcttatttt aggttatttt attcccggcg tcagacatgt 228601 gacgtgctac ttttcgggga tcggcaaaat ggatctgaaa acgtatgttg cgtttgctgc 228661 aatcggcgcc tttttatggt gctttgtttt tattacaatc ggaagggtta tagggattat 228721 tcatgtttaa tacggctgta aagattctgt atcgatcatt gatagagctg acgaatcatc 228781 gtctgtcatc ctatctgatt aaaggatttt gcgagtcgaa aatcagcaaa ccggtcattc 228841 cgcttttctc aaaacatttt cggctgaatt gggatgatgt ggacggtacg gctgctgatt 228901 acggatcgct gtccgaattg ttcattcgac aaataaatct ggagcggcgc cctgtgtcaa 228961 aagaggcgca tgcggtggtc agccctgttg acggtgtggt tcagacggta ggaatcatca 229021 acccgaatca aacctttacg gtgaagggaa aagattactc attcgctgag ctgaccggct 229081 gtaaaagcgc agaccatcaa tacaacggcg gatatttcgt cgtgctgtat ttaagcccga 229141 ggcattatca ccgtttccat tctccgatca gctgcaggta tcaaaagctg gccgagctcg 229201 gaaatcgctc atacccggta aatcaactag gcttaaaata cgggaaagat gtgctgtcga 229261 aaaattatcg gtttgtgtac gagctgaata gcggcagccg aaatgtcctg atgattcctg 229321 tcggcgcgat gaatattaat tctatcgtgc agacgaatac ccgtactgaa ttggagatcg 229381 gcgaggagct gggatacttt tcatttggct caaccgtcat tttggttttt gaaaaagacg 229441 cgttccagcc gtccgcccat ttagcagaag gccaagaagt ccaagtcgga gaactgatag 229501 gttacgaaga ataaaaagag gagcttgcat aaacgcagcg cctctttttt tgaagaaagg 229561 tgagattcat ggagaaacaa atcatcagct ggattacaga ttatcagaac accggagatg 229621 aagccgtcct gcggcaagtg cgagaagtgt gctggccgat cgttgaagcg gttttgcaag 229681 agaaagtaat ggatgatgaa caagcgaaca atttgcgcga aaaaggaatc gagcggtttc 229741 cattcatcat cagcaaatac caagcggatg tgcagcttcc ggttgagaca tttttacaaa 229801 atacgtatcg gttttacttt catcaggtga tgagagaatc cagctaaagc ttctttcaac 229861 agagaagctt ttttttgttg gcaggaaaag gaaacttttt ctatatctat ctcgtaatga 229921 ctagagaacc tagcagaaaa ggagagatag aattgaaacg aatgatagtg agaatgaccc 229981 tgccgctgct gatcgtttgt ctggcgtttt cttctttttc agcctcagcc cgtgctgctt 230041 ctgaagaaaa atattgggat cactggattg aacgacatgc acagcctctg gatgcttcca 230101 atgcttcaaa caaagacctt cgatttctaa aaaaggtgct gaagggaaaa cgaatcgttc 230161 agttaggaga aaccacacac ggtgctggcg aaatcaatgc cacaaaggtc agaatgatca 230221 aatacctcca cgaagagctg ggatacgatg tattggcctt tgaatccggc tttcctgata 230281 caaatgcatc ctaccttaat atggaccaat taacccctaa aagcacgatg aaaaactcca 230341 tttacgctgt atggcacaca gaagatgtcg tcgaattgtt tgattacatg aaagagcaaa 230401 aagagaaagg cgatccgctg atccttaccg gttttgatat tcaaagcatg aagaattcat 230461 tcaatgtagc tgcgactcaa tgggtaaaag cggtggaccc tgagaaagca gagttgctct 230521 cccaatcaga aaatgatttt tcaacattag tgacagacag caatacgttt gatgaatttt 230581 cgcaaaagaa ggaaaagctt gtgaaaaact atcagaagct gatcaagttc actaaaacac 230641 atgcttcaga gctaaaagaa aaccttccaa aagagccgaa agcttatgag atgtttatgc 230701 attctcttca gctgagaatt gacgtaatgg aaacatatat gctggaagaa atgaaagaaa 230761 aactagagga gtatccggag aatattgagg atttttcatt ctttatgaga gaccgcatga 230821 tggctgaaca atttcagtgg gtagccgaca ccctttatcc gaaaaagaaa atcattgtct 230881 ggggccacaa ttaccatcta cgcaaacaga atacgaagat gataaaggac tgggtacagc 230941 taaacggccc taacatgggt gattatttgc cggagcggct gaaaaaacaa acatatacga 231001 ttggcattta tgcttactca ggtgcgagtc ttgatagctc cgataataag actgttaagc 231061 cggttacaag cccgccgccg tctgggagcc ttgaagcttt gctgaaagcg gcggaccgac 231121 cggctgtttt tgttgatttt ctccatacaa aaaacaagaa aggcacttcg tggatgtata 231181 ccccgcggac tgcgctctat tgggggtaca tggaagagca gatgatcctg aaggaacaat 231241 atgacggtgt catttggctg gagcatatca cgccctctgt cattatcaag tgagcggtgt 231301 cccctgtggt aaacagggga tttttacata tcgcaaaaat aatcaaaaca tataatccgt 231361 gatccattat tctaaaacag aaaggagatt ggagcgtgca atgtattatg aaaaagctgt 231421 ccagaaaaca atcaattgga ttgaatcaca tttacatgag caaatatcaa acgaggatat 231481 tgttaacgtt tcaagctttt caaaattcca ttttcatcgg atttttcaaa aagaagtcgg 231541 catgtcggtt gcttcttata ttcggttaag acgtcttgcg aatgcggcgg cagctttgct 231601 ttatacagat catcgtatta tcgatattgc tttgtattat cagtttgaat ctcaagaagc 231661 atttacgagg acgttcaaaa agatgtatca catgccgcca ggagcatacc gaacatttat 231721 gaaacgcttt acttcaaaaa aggaggaatc ttacatggag aaaaaaatga aaggctgggt 231781 attgagcggg agccatccgt tccaattcga aatggggatt gaccgggaaa atgtacatca 231841 gggaaaagct tcagggtatt taaagtcaac gatggttcag gatatcggtg aatttgcgac 231901 gatgatgcag caattcaaag cagatcgcta tctaggaaaa aggcttcgtc tatcaagttt 231961 tatcaaaaca aagggggtgc agcattttgc ctcactttgg atgcgggttg acagtgctgc 232021 tgatgatgtt ctccaatttg ataatatgag caacagacct attaccggaa caaccaattg 232081 gaatcattat gctatcgttt tagatgtccc agaaaatagc gctgtgatat cttttggcgt 232141 tcaattatct gggccgggtc aggtgtggat ggatcatgtt gtttttgaag aggtagatga 232201 gagcgttcct tcaacaaacc ttgaaatgcc gggagaactt ttagatgaac cggtaaattt 232261 atcttttgaa gaggaactac aaaaatagtt ttcagacaac tacttttatt agtgagttaa 232321 tggaaaatac tatttgttat taataaaccc ttgtgctgct taggtttgta agagcttgga 232381 tatttttatc agtctgggcg gatctgttca tctttgcggc attttcctgt atgatatagt 232441 aagagtgtgc atagcaacta actataattg aacagggtgt ttaaaacatg gaaaaacaat 232501 acagagtatt actttactat aaatatgttc cgattgaaga tccagaggcg tttagagagc 232561 agcatctggc tttttgtaag gagcttggtt tgttaggccg tatccttgtt tcttctgaag 232621 gaattaacgg tacggtatca ggtacggttg aacagactga aaaatatatg gaaacaatga 232681 aagctgatcc tcgctttgcg gacatggtat ttaaaattga tgaagcagaa ggccatgcct 232741 tcaaaaaaat cttcgtccgc cataaaaaag agcttgtaac gcttcgtctt gaagatgatg 232801 tcgatccgaa cgaaacaaca ggccagcatt tgaagcctgc agaattttat gagaagatgc 232861 aggatccaaa cacaattgtc atcgacgcgc gtaacgatta cgagtatgac cttggccatt 232921 tcagaggtgc ggtccgtcct gacatcgaag ccttccgtga attacctgaa tggattgaag 232981 agcacaaaga tatgcttgaa ggcaaaaaga ttttaacgta ctgtacaggc ggcgtgcgct 233041 gtgaaaagtt ctcaggatgg ctggtgaagc aaggctttga agatgtagct cagcttgatg 233101 gcggaatcgt gacatacgga aaagatccag aggtgcaagg caagctttgg gacggccagt 233161 gctacgtatt tgatgaaaga atcagcgtgc ctgtcaaccg tgtcgagcat gtgattgtcg 233221 gcaaggacta ctttacagga gaaccgtgtg agcgttatgt gaactgcgca aatccatctt 233281 gcaataaaaa aatgatatgc acaccggaaa atgagtataa atatatgcgc agctgcagcc 233341 acgaatgccg cacgaaccca agaaacctgt atgtgaaaga gcataatatg acagaagaag 233401 aagtaaacgc aagactggca gcgattgaaa cagaagatca cgctgctgct gaataaaaaa 233461 agaacacctc gtattgaggt gttctttttt tctatatgct ttcagtttgg ctgtttgcgg 233521 aaacccattc tttttggcgg aaggcctttt cccattttga taccacgata caggcgatcg 233581 catgtcccgg tacgttcacg cctgttctcg ccatgtccat gacgcggtca acacccgcga 233641 taatggcaac gccttcagcc ggcagtccta cagcattggc agtcgccaga agaactacaa 233701 gcgatcctga gggtacagct gcaatgcctt tactggtcat cacaagcaca agcatcatga 233761 gcagctgctg ggacaatgtc atgtctactt gaaaggcctg tgcgagaaag atacaagaaa 233821 ccgataaata taagctggag ccgtcacagt tcaatgacaa gccggaggga acgacaaatg 233881 ataccactcg tttgggacag ccgtatttct ccattctatc catcagctga gggagaatgg 233941 tttcagtgct tgtggtggaa aatgcaatta aaaacagatc ccatatcatt ttcaatactt 234001 cgaaatactt aatctgaaag atgagaccga caagcggaaa gaggacaaag aggatcagga 234061 acaggccaag gaatacggtg ccaaccagct taaacatagg gaggaggagt tcaatgccat 234121 attggcctac agaagcagcc atcagggcta acacgccgat aggagcagtg accatgacga 234181 tttgcgtgag cttgaacata atctgagctg tagattcaaa aaacttcatt actggttcag 234241 aagctttgcc gataccagct gcggcgacac caaataaaat ggcgaagaaa ataacggcaa 234301 gcaaatcatt tctggccatg acatcaataa tgtttgtagg gataatatcc aggatcattt 234361 gcttgaaatc aacaactttg tctgtgtagc cggaaagttc atgaatatct ttttttgcca 234421 aatgggagag gtcaagcccg acacctggtt ttaagacatt cgctaataaa agtccaagcc 234481 ctaataccaa cgttgtaatc acttcgaacc aaatgatcgt cttgatgccg agactgccca 234541 tttttttcat gcttccgctt cctgcggctc caatgacaat ggtagaaaat acaatcggca 234601 caacaatcat tttaatcagg cggataaatc catctccgac aggcctcagt gccatcccga 234661 aatcaggaaa aaagtggccg atcaccgcgc cgacagccaa agcgattaaa atttgaaacg 234721 cgattaattt tttcaaatga atcccccttt agaacgatag aatgtaggca tattcatatc 234781 attcgtgatt caaatgcaaa cacctttttt caagttattt tattttgaca gcgctttcat 234841 tatgttggcg aaaaagtccc ccgcagcagg ggggactttt ttacttcatt tgaatgtgct 234901 ttagatcttc ttcagaggta tttgtgaaaa taaccggtgt tatggctgaa gcggcatgct 234961 gcttgatgta attgagatca aaggtgagaa gcagttcgcc ttgtttgacg gcttgtccgc 235021 ttgtgacatg tgcttcaaag ccttccccat tcagtttgac ggtatcgatg ccgacatgaa 235081 tcaggatttc agtgccgccg gcgctcataa agccgatggc gtgttttgtc ggaaaaatcg 235141 agacgatctc gccgtccgca ggtgcaacga cttttccttc tgatggtata atcgcaaatc 235201 cctcgcccat cattttttct gaaaagacct gatcaggcac atcccctaaa gagactgttt 235261 ctcctttaat cggataaata aaggtctcat cggaatcggg cttcagcggt ttgtcagtta 235321 ccgtgtccag cgcggcggcg gtggcaggga cgcctccggc catgattgtt ttgatgtcgt 235381 cttttaaggc atcggacttg gttccgaata ttgcctggaa gttgttgttg acctccagca 235441 cacctactgc accaagccgt tttaattcat ccttgcagac ttggcttggc tgatgaacgg 235501 tcacacgaag ccttgtgata catgcatcca ggttagcgat attttgctgt ccgcccaagg 235561 cctgcagcac gtgaaaggca agctggtctt ttgcaactgg agctttctcc tcattctgac 235621 cgtcttcatc tgtctcacgg ccgggcgttt tcaaattcca tttcagaatc gcaaatcgga 235681 acaaataata ataaatgaaa gcaaacacga tcccgacagg aatgacaacc cagccgtttg 235741 tagacagtcc gtagttcaag acgtagtcaa ttcctccgcc tgagaacgta tagccgtggc 235801 ggacatggaa taaatcacaa acgacaaaga tgacgccggc aagaatagag ttaatcaaat 235861 agagcacggg cgcaacgaac aagaaagaaa actcaaccgg ttctgtaatt ccggtcagca 235921 tagatgtgag cgccgcagaa atcatcacgc cggagatcat ttttttcttt tccggacgcg 235981 cggtatggat aatggcaaga gcaacggccg gcagacagaa aatcatgtaa gggaaatccc 236041 ccatcataaa gcgcccggct gtcgggtctc ccgcgaaaaa ccttgtcagg tcgccggtta 236101 cggtgttgcc tgttgatggg tctgtgtatt ctcccatcat aaaatagaaa ggcgtataaa 236161 aaatatgatg caggccaaaa ggaatcagca aacgatagat cgttgcataa aagaacaggc 236221 cgactgttga atcggcaatt aaactgctgg ctgcgttaat tccgttttgg atcagcggcc 236281 aaacgaatga gaaaatgacg ccgatcacca atgaactgac ggaagtaatg atcgggacaa 236341 agcgttttcc agagaaaaat ccaaggaccg gatgcagctc gattgatgaa aatcgcttat 236401 ataaataggc ggcgagaagc ccgataatga ttcctccgaa aacccccata tcaatcaggt 236461 gctcggctcc ttcatacgga ggctgaaggc cgagtaattt tcccatattg tcgagggtga 236521 cggttaaaat taagtatccg atgacagcgg caagtccggc tacaccttct ccgccggcta 236581 atccgatcgc gacccccacg gcgaaaatca gcggaaggtt atcgaataca acgccgcccg 236641 catcctttat aatagggatg ttcagtaaat ccttgtctcc gaaacggagc aaaagacctg 236701 ctgccggcag gacggcaacc ggagtcatca acgcgcggcc aagctgctgc agaatttgaa 236761 atgccttttt aaacatgaca gtctcctttt attgtgttat gagaatgatg cactctttaa 236821 tttttgagct gctttataat cggcgataac ggttacatga ttgtgttttt gaagaatgga 236881 ggctggtaca tctgtcgtga caggaccttc agccatcttt tgaatggcgt ctgctttttc 236941 ctcgccgctt gctaaaagca caatatgttt gctgaattcc atgatggttt taatgcccat 237001 tgaaatcgcg agtctcggaa ccagcaccgg atcgccgccg aagaatctgg catttgcctg 237061 tatcgtgctt tccgagagct tcacaacacg tgtccggtct tcaaaatcag atcccggttc 237121 attaaaaccg atatggccat tggcgccgat gccgagaatt tggacatcaa tgcctcccgc 237181 ctggcggatg agatcctcgt atactttgca tgccgcctca agctgcggat tgtctccttg 237241 cgggatatga atatgatcag gctgcatatt gatatgctga aaaagatgct catgcataaa 237301 atggttataa ctttgcggat gagatggaga gagaccagca tattcatcca aattaaatgt 237361 agtaaccttt gaaaaatcaa tttcgcctgc ctgatagtct gaaatcaact gcttatacaa 237421 gccgaccggt gtgcttcctg ttgccaggcc gagaacggca tctttcttag cttgtatttg 237481 ttctttaata atggcagcgc ttaacttaca gagttcttcg tagtgctcgg cgatcagaat 237541 cttcatgtga caccccctca aagagataga caagcaccat atttgttatg accaatttat 237601 gatacttgtc attacgaatt tagcaccgcc cttatcaaac tgtcaatatt aatttctgaa 237661 aatttgttat aaaagaagga tacaaatctt tcatattggg agggcaaatg gtattatggt 237721 ctcaatgaaa aagaacggat tgcatacaga atggggagaa tgaaatgaca gctttatatt 237781 ctgttatcaa gtttaaaatc attgagttaa ttaaatcggg caaatatcag gcgaatgatc 237841 agctgccgac ggagagtgag ttttgcgaac aatatgatgt cagcagaaca actgtgagac 237901 tggctctgca gcagctagag cttgagggat atattaaaag aattcaagga aaagggacat 237961 ttgtatcggc ggccaaaata caaacgccga ttccgcataa gattacgagc tttgcagaac 238021 aaatgagagg acttcgttct gaatcaaaag tgcttgagct tgtggtgatt cctgccgatc 238081 attccatcgc cgagcttttg aaaatgaaag agaatgaacc tgtcaacaag cttgtcagag 238141 tcagatacgc cgagggggaa cctttgcagt atcatacctc atatattccc tggaaggcgg 238201 caccggggct ggcgcaggag gaatgcaccg gctcgctgtt tgaattgtta aggacaaaat 238261 acaatattga aatcagcagg ggcacggaat cgatcgaacc gattttaacg gatgaaacga 238321 tcagcggaca cttattaacc aatgtcggag cgcctgcgtt tttatcagaa tcccttacct 238381 atgataaaaa tgaagaagtg gtggaatatg cgcaaattat tacacgggga gaccgaacga 238441 aattcaccgt agaacagtca tatcattcat aaagcaatgt gttttaagaa gggaatggtg 238501 gttctatgtt tttatttacg aatggaaaag tgctgtgggg agcagtgatt gctgcattca 238561 tcctttcaat tgtattttac ccttttctgc cgacgcagat gccgattcat tatgatgttg 238621 cgaacagtcc ggatctgacg gttaacaagc tggcggggac tgtgatgctg cctgttttga 238681 tggtggtgtt tgcatgggcg cggaagatca attggcaatt tgtattcgca gtgtatattt 238741 tgctgatttg ccacattgtc gtcctttgtt tagcgctcta aatcaaacag ccagaataaa 238801 actggctgtt ttctttaatt tcagcttcat ctgacaatga atgtggtgta taatagctga 238861 tgatcctaaa gaatattctg aaatttatag gtgtgaagcg gcgtattatt aaaggaaagg 238921 ctgtatactt tttgcagctt taaaaagact gaatatttaa acaattatgt gaaaggtgtg 238981 ctgattagat tgaataagct tattgaacga gaaaaaactg tatattataa ggaaaagccc 239041 gacccgtctt ccttggggtt tggacaatat tttacagatt atatgtttgt gatggactac 239101 gaagagggga ttggatggca tcatccgaga attgcgccgt acgcaccgct tacgcttgat 239161 ccgtcttcat ctgtttttca ttacggccag gctgtttttg aaggattaaa agcatacaga 239221 acagacgacg gcagggtgct gctgttccgt ccggatcaaa atatcaaacg gctgaacaga 239281 tcgtgtgagc gcatgagcat gcccccttta gacgaagagc tggtgcttga ggcattgacg 239341 caattagttg agctggagaa agattgggtt ccaaaggaaa aaggaacgtc actgtatatt 239401 cgtccttttg tcattgccac agaaccgagt ctcggtgtga aggcatccag gagctataca 239461 tttatgatcg tgctttcgcc tgtcggctcc tattatggcg acgatcagct gaagccggtt 239521 agaatctatg tcgaagatga gtatgtgagg gcggtcaacg gaggagtcgg gtttgcaaaa 239581 acggctggaa actatgccgc cagtcttcag gcacagcgga aagcgaatga actgggctat 239641 gaccaggtac tgtggctgga cgccatcgaa aagaaatatg tggaagaagt agggagcatg 239701 aacatctttt tcgtcataaa cggggaagct gtcacacctg ctttaagcgg aagcatttta 239761 agcggggtta cacgtgcgtc tgcgattgaa ttgattcgaa gctggggcat tccggttcgt 239821 gaagagagaa tatcgattga tgaggtgtat gcggcctctg cacgcggaga attgacagag 239881 gtctttggca caggcacggc agcagtcgtt acgcctgtcg gtgaactcaa catccatgga 239941 aaaacggtga ttgtaggcga cgggcaaatc ggggacctct cgaaaaagct gtatgaaacg 240001 ataacagata ttcagcttgg caaggtaaaa ggcccgttta actggacagt ggaagtgtga 240061 aaatcgaaaa agaacctgcc cggaggcagg ttctttttat tttgaatgag tcatatcagc 240121 agccggctgg cttttgcggt tttttacata atatattgca tagcaaatgg ccataaatgg 240181 aacgccgcaa tagagtgcga ttctttgatt cggatcaaag gcaatgccaa cgacggaagc 240241 caggcataac aggaacgcag caatcggcac gaacggatac aaaggggttc tgtatttcaa 240301 atcagtaacc ttgtttcccg cttcgatata acgttttctg aacatgaatt gagaagcagc 240361 gattcccatc cacacgacaa cgacggcaaa accggaaatc gacacgagca caacgtatac 240421 agtgtctggc gcaaatacgc tggacagcaa cgacagaatg ccgccgatca tgctgaacac 240481 cagcgcgtta aaaggggttc cttttgacgt cagctttgca aatgtcggat gaagcgtttt 240541 ttcttttgat aaagaccaca gcatccggga agaagcgtag agtccggaat tagccgctga 240601 caggatcgct gtcaggataa caaagttcat gatatcggct gcgtatggta caccgactct 240661 gtcaaagaca gcgacaaacg ggcttttgat gacacctgca tcttgaatcg gaatcagccc 240721 tgacagcaca aaaattgttc cgacaaagaa gagcgagaga cgccagaccg ttgtttttat 240781 cgcttttggt atcgtcttgt caggatcaac gctttcaccg gctgcgattc cgattagttc 240841 cgttcccgaa aaggcaaaat tgacggacag catcgtcatc aaaatcggga caaatccatt 240901 gggaaaaagc ccgccttccg ccgtgaagtt ggacagcatc ggagcggctt ctccgccttt 240961 gatcgggatg atgccgaaca tggcagagcc gcctaaaaga ataaataata caatggctaa 241021 tactttgatg ctggaaaacc aaaattctga ttcagcgaaa aacttgaccg aaaatgcgtt 241081 aagcaagaag atgaacagcg caaagacggc actccacatc caaaccgatg tatgggggaa 241141 ccagcgctgc attaacaggc cggctgctgt gaattctgat cccaatgcca cggtccatgt 241201 cagccaatac agccaagcga ccgtaaatcc ggtgcccggc cctatgtatt tggctgcata 241261 ggtgtgaaag gcgccggtca caggcatggc gactgacagc tcaccgaggc atagcatgac 241321 cagatagacg atgccggccc cgactaagta ggcgagtatc gttccggccg ggcctgcttg 241381 ctgaatggta taacctgagc ttaaaaacag cccggttccg atgacacctc ccaaggaaag 241441 cataaagagg tgccggcttt tcatacttct ctgaaaggtt gtctcattct tgttgtgggc 241501 agagttcatc tttttccaac tttctatcag cgatttattt ccttcctaat aaaaaatctc 241561 atgtcagaaa gtgacacgag actccggcga accggcttta agttagaata tacaaactat 241621 tccgataagt caagttgttt ttaaagagcg ggcccaagcc gcaatttctt gaatattttc 241681 gggttttgtc cggcagcagc cgccaatcag cctcgctcct ttttcatgcc aggtgcgggc 241741 gctcgccccg taagattctg cgcatgctgc gccgttccac gtttttgttt ccggatcata 241801 ttgctcacct gaattcgggt agacaatgat cggttttgac gtgttctttt ttaactcctc 241861 tatcaaggaa gggatatgct gaagcggcgt gcagttgatg ccgagtgctg caatttggcg 241921 gtgttcatca agccacgatg cgcagtcagc tgcaggtgtt ccgtcactga tatgcaagcc 241981 gtctttagca ctgaagctga tccatgcata cgtttcagga aattccttca acagccgaac 242041 aatcgctttg gcttcagtca gacacggaat cgtttcgcat gccaatacat cagctccggc 242101 ttcaatcagc gccttcatcc gggggcgatg aaattcaatc agttcatctt ctgatattgc 242161 gtagttgccg cgatactcag acccgtctgc aagataagcg ccataagggc ctatagaagc 242221 cgcaatgatc ggttttggcc gattcaaacg gttctcttca agcgaccaaa attcatcacg 242281 tgcttcagct gcgatgctga cggacaactc gatgagccgg cgtgcttccg cttcgctcag 242341 cccgcgtgcg gcaaagcctt caaatgtaga ctgatagctg gcggtgattg cacaatcggc 242401 gcctgccgca aaataatcag tatgaacttg tttaatcagc tccggctctt ccatcaggat 242461 ttttgccgac cacagactgt cattcaaatt acagcccttg cgttcaagct cggtcgccat 242521 ggcgccgtct agcacaataa gcgggtatgt atctaatatg tgttggatag gattcataga 242581 atgtaccgat gccttctttc agattttttt gaaaaagata tgaaaatcgt aatggaggct 242641 tacgtgtttg tcaataaacg caaaaagaga aaggtgttca gcccatatgt ctgaacaccc 242701 ttttcttatg atatttgttt gttgtgcgtg tcagtctttg tgtctgaaac cggccagcac 242761 tcaatgccat tatggttttt gagcacatct ttataaaaga ccggatcctt gcctgctttt 242821 ttctggcgtg tatagtcttt cagcgccgta aaaacgacct ttgatagtaa gaaaatcgcg 242881 attaaattca cgatgaccat caaacccatg aacaaatcag caagatccca gacgagctgg 242941 actttggcaa cacagccaaa cacgatcatt gccagcacgc cgatacggta gacaaaaatc 243001 agttttttgc ttttgttcaa aaagccgata ttggtttcgc cataataata gtttccaatt 243061 agagcacaga atccgaataa caaaatcaga atcgcgagaa agcctgatgc ccatgatccg 243121 acatgggagc tgagggaggc ttgtgtcaag gcgattccgc tcagacccgg agtatgatag 243181 gcatccgaaa acagaatgat aaaagcggtg cttgtacaaa tgaccagtgt atctgtcagt 243241 acaccaaaag cttggatcag cccctgtttg acgggatggc ttgttgtggc ggtggcagcg 243301 gcatttggtg cgcttcccat tcccgcttcg tttgaaaaga ttccccgtct gacgccttgc 243361 atgagtgccg cgcccaaagc cccgccggcg gcctggtcaa aaccaaacgc atttttcacg 243421 attagcgcaa gcacacctgg cagctgcgta atgttggaga aaatgacgaa aaacgcaact 243481 ccgatataca ggacagccaa tacgacgaca atggattcag ccagctttgc aatgcgcttg 243541 actccgccaa aaataatcgt gccgaataca gcaattaaaa tgagtcccaa tgtcaggcgg 243601 tttgtgccaa acgcgttttc aaaggcaagg ctgactgtat tggattgaac cgagttgaag 243661 acgataccga acgataaggt gattaacaca gcgaacagcg cgcccatcca ccttttgttc 243721 agcccttttt ccatgtaata cgccggcccg ccgcggaagc cgtttacatc ttttacttta 243781 taaatctgag ccagtgtgct ttccacaaag ctggatgctg atccgataat ggcgataatc 243841 cacatccaga agattgcacc gggcccgccg agtgcaatgg cgatagcaat gcccgtaata 243901 tttcccgttc cgacacgggc cgccatgctg atgcaaaagg cttgaaacgg agaaatgctg 243961 ttttttgacc gggaagcagc accttctctt aataccctga ccatttcttt cagcatgcga 244021 acctgtaaaa acttaagcct gaacgtaaaa tagattccaa aagaaaggag caaaacaatt 244081 aatagctttg accacaaaag atcatttgca ataccgacga tatgttctag gatttgctgc 244141 atagaatcac ctcttttttc atgtttaaaa aatgctgagc tcccattcct gcgccatatg 244201 cttcagcagc ataccgccag tgaggctgtt gccgtattca tcaatggcag gcccgtaaat 244261 gccgatgccg catccggatt gaaaaggctg ttctcttctg gcgcttggag gcaccagcgc 244321 catgatgccg ccggagacgc cgcttttggc cggcacgccg acaaacgccg catatttgcc 244381 tgaagcgttg tacatgccgc acgtcagcat taatgccttg gccaattttg ccacatcttt 244441 tggaatcacc tgctcgtgtc gaatcggatg atacccgtca tgagcaagga tcaggccgat 244501 caacgcaata tcttctgtag tgctctccat agcgcattgc ttcaagtaca cctcaagtgt 244561 ttcttctact tcagcttcta aaaagtttgt ttcttttaaa tagtaggcca gcgctctgtt 244621 gcggtgggcg gtttcccatt cagaacggaa tacttcttca tgaattcttg gccgttttcc 244681 tatcaaagtt tccatcaccg agtaaagaaa ctcgagcttt tcgtatgcag attctccggg 244741 aaggatcgaa gcgatggtga gggcacccgc gttgatcatg ggattgaagg gctttcccgg 244801 cttgttgatt tcgagccgaa tgattgaatt aaaggcgtca cctgtcggct cgacatctac 244861 gcggtcaagc acatagggaa tgccgcggct catgcaggcg gcaataaagc taatcacttt 244921 tgaaatgctt tgcatggtaa aagagacgtt ccagtcgccg gcgtgtatca tcgttccatc 244981 aggctccaat acacagatgc cgagctgtga atcattgact tttcctaaag cggggatata 245041 gtttgcgctt tgtccattgg cggcaaaagg gcgatagtat tcaacccaat catgaagctg 245101 taacgccggg tttatgtctt tctggtgctc ttttatcaat tctttcatcg aattcctcct 245161 cactgatttt tttcttaaag gactgaggtg tatcaaaacg aaggctaagg gggcgttaaa 245221 cgctttcata atagcggaag gtataattac tgtataatgg agactacaga atcatacaaa 245281 atacgacaaa aacattttga aaataagcag taagatttat aaaaacctca tgttctgggt 245341 caaaagcaat ttgcaggttt tctcccgatt ccccaaaata aaaagcgagg atgtgatcaa 245401 cataaaactg gaacggttta ttgaaaaaga cggatatata ctggccctca tgctgattac 245461 ggtgccgctg gccggtgaac tgaaatttta tcccctcaat gaagaattcc gggtcagctt 245521 tggggcaccg gtttttttct tctttttatc attgttgcgg catgtgcccg ctgtgctgcc 245581 gggttttctg actggagcgg ctgttttcat ctttcgcgtc tttctggaat tatggggcgg 245641 aggacacaat gggctgactc cgattctgta tgatcaagcg tctggctttt tcttttatat 245701 gacttacgcc tgtctgtttt ccatattaaa ggccaatcgt ttccgtgaac ggccgattat 245761 gctcggtttc attgggttta tgattgaagt tgtgtcagat tgtgtcgagc taactgtgca 245821 atttctcatt tttcatacgg ttgtcacgcc tgagaaaatc actgacattg cggtgattgc 245881 gatttctcac acatttattg tgatgagctt ttatagtgtg ctgaagctgt atgaaacaca 245941 atcgagagaa aaacagacaa ggcagcagca cgagcacatg ctgatgatcg tttccaattt 246001 atatgaagaa acggtgcacc taaaaaagac attgaaaacg acagagaaag tgacaaacga 246061 ttcgtatcag ctctatcggg aaatgaaggg caaggatgtt cagctgagcg gcagaatcct 246121 gagactggcc ggagagattc atgaagtgaa aaaggacaac cagcggatat tcgcagggct 246181 ttcaaaactg atttcgaatg agagtttgag agattatatg agggcttctg atttgctgca 246241 gctcgtgatt cgaatgaatg aaaagtacgc tgaagcacta gggaagcaga ttgattttta 246301 ctgctcgatc gagggagagc atgacgaata tcacgtattt atcgtgcttt cgatcattaa 246361 taatctaaca gcaaatgcgg tagaggctat ggatgaagag ggaatggtca gcctgaggct 246421 ccgtaagcca aatgagagta tggtagaatt ccaggtggaa gacaatggcc ccgggatttc 246481 cgagaaaatc ggagacattg tgtttgaccc gggctttact tcaaaatatg acgaatttgg 246541 cacgccttct acgggtatcg gactttccta cgtaaaggaa atcgtgacag agctagaagg 246601 ggatatcacg tttgataatc agcagcgggg agtggtgttt gccatcaggc tgcctgtccg 246661 gcatttgatt cagaaagggt gaaccaaaag ctatgcgttt ttttattgca gatgatgacc 246721 gtgcggtgcg gtcaatttta aggcagatca ttgaggacga agatctcggg gaagctgctg 246781 gtgaagcaga cgacggaagc caagtggaag ggcatatgct gcaatttaag cagattgata 246841 ttttattaat cgatctgtta atgcccggaa gagacggcat tgagacgatt cgtcagatcc 246901 agaatacgta ctccggcaaa atcgtaatga tctctcaagt ggaggcgaag gaaatggtcg 246961 gggaagcgta ctcgctcggc atcgaatatt ttatccataa gccgattaac cgcattgaaa 247021 ttgtcacggt tctccaaaag gtgaaggagc ggatcgagct tgaacactcg attggagcca 247081 ttcagcattc tctaagccgg cttgtcaatc ggactgaacg gaaagcgcgt ccccagcaga 247141 agagtgacag cggtttaaaa gaggcaggaa cattcctgtt gtccgagctg ggcatgatgg 247201 gagaaggcgg cgcacatgat ctcatggcgg tcctgcagta tttagcagaa cacgagcaat 247261 ccgagccgca cgaaaaacaa agcccttcgc taaaacaaat attcacccaa gtagcggtac 247321 ggaagctggg gacaggagcc tcacagacgg aagtcaatcg cgaaatgaaa gcctcggagc 247381 agcgtatccg cagagcgatt attcattcgc tgcaccattt tgcttcactg ggcacaactg 247441 atttttcgaa tccaaaattt gaaacctatg catcgaaatt ctttgatttt ccggttgtca 247501 gccagaaaat gaaagaactc caatccaagg atgcaaaacc ccttgcacct gctagaataa 247561 atatgaaaaa attcatccac gtgttttttt tggaagcaaa gcttttgcat gagacgatga 247621 aacaaagaag gatataaacc aaacagccgg ctgaccaggc tgtttttttg ctgcgcagaa 247681 tcccggccgg acagtgattt accgcttttt tataaaatat cagaaaataa agatattgac 247741 ttattgttta tttgtcttac aattaaacaa aaggatatat gggaaggagc ggatgtgaaa 247801 gaaaaattaa taaaagcgct tacagataga ggccgtatac acaaataaca ggaggttatg 247861 ttgatgagcc gtatcagaaa agcacccgct ggaattttag gttttccggt tgctcctttt 247921 aacacacaag gaaaactgga ggaagaagct ctttttcaaa acattgagtt tttgctgaat 247981 gagggcttgg aagcgatatt tatcgcttgc gggtctggtg aattccaatc tctcagccag 248041 aaggaatatg agcaaatggt ggaagtcgca gtctcggcag ccggaggaaa ggtgccggtc 248101 tacacggggg tgggcggcaa cctcagcaca gcgcttgatt gggcgcagct gtcggagaaa 248161 aaaggcgccg acggctactt gattctgcct ccgtatttgg tgcatggcga acaggagggg 248221 ctgtaccagt atgcgaaaac gattattgaa agcactgact tgaacgcgat tctttatcag 248281 cgcgataacg cagttctctc tgttgaacag atcaaacgtc tgaccgaatg tgaacagctt 248341 gtcggtgtca aagacggggt aggaaatatg gatttgaata tcaatctcgt ctatacgatc 248401 ggcgaccgct tgggatggct caacggaatg ccgatggctg aagtgacgat gccggcttat 248461 ctgccgatcg ggttccactc ttactcttca gcgatttcaa attatatccc gcatatttcg 248521 cgaatgttct atgatgcatt gaaaaacgga aatgacgagc ttgtgaagga actctatcgg 248581 catgtgattc tgccgatcaa cgacattcgc aaacaacgaa aaggctacgc cgtatccttg 248641 attaaagccg gtatggaaat catgggtttg aatgtaagga atacagccag accgcctgtc 248701 ggcccggttg aaaaagatca ttatcagcaa ttggaagcaa ttttgaagca ggcggctgac 248761 cgttttccga aaaaagccgc gacggtttga ccagaaaaaa cacgaaaggg gcaatgggca 248821 tgtctgtgat cacggaacaa aacacgtacc tcaactttat taacggagag tgggttaagt 248881 ctcaatcagg cgatatggtc aaagtcgaaa accctgccga tgtgaatgat attgtcggat 248941 atgtacagaa ttcaacggct gaagatgtgg aacgtgccgt caccgccgcc aatgaagcca 249001 aaacggcttg gagaaagctg acgggtgccg agcgcggcca atacttatac aaaacagcgg 249061 atatcatgga gcagcgcttg gaggaaatcg ccgcctgtgc aacgcgtgaa atgggtaaaa 249121 cattgccgga agcgaaggga gaaacagccc gggggattgc cattctgcgc tattacgccg 249181 gagagggcat gcgaaaaacg ggtgacgtca ttccgtctac tgacaaagac gcgctcatgt 249241 ttaccacccg tgttccgctc ggtgtggtcg gtgtgatttc tccgtggaac ttcccagtgg 249301 cgattccgat ttggaaaatg gcgccggcat tggtatacgg caataccgtt gtcatcaaac 249361 cggcgacaga aacagctgtg acatgcgcga agatcattgc ctgctttgag gaagcggggc 249421 tcccggcagg ggtcatcaat ttggtgacag gcccgggttc tgttgtcggg caggggcttg 249481 ctgagcatga cggtgtaaac gccgttacgt ttaccggttc aaatcaagtc ggaaaaatca 249541 tcgggcaagc cgctttagcg aggggagcca aatatcagct tgagatgggc ggcaaaaacc 249601 ctgtcatcgt agctgatgac gctgaccttg aagctgcggc agaagctgtc ataacggggg 249661 ccttccgttc aaccggccag aaatgcaccg cgacaagccg tgtcatcgta caaagcggaa 249721 tttacgagcg ctttaaagaa aaactgctcc agcgcacaaa agatattaca atcggagaca 249781 gcttaaaaga ggatgtctgg atgggaccga tagccagcaa gaatcagctt gataactgcc 249841 tgtcatacat tgagaaaggc aaacaggagg gcgcttccct tttaatagga ggagaaaagc 249901 tggagaacgg aaagtatcaa aacggctatt atgttcagcc tgccatcttt gacaatgtga 249961 catctgagat gacaattgcc caggaggaaa ttttcggtcc ggtgatcgcc ttgatcaagg 250021 tggactcgat agaggaggcg ctgaacatcg ccaatgatgt gaagttcggt ttaagtgcat 250081 ccatcttcac ggaaaacatc ggccgaatgc tttctttcat tgatgaaatc gatgccgggc 250141 tggttcggat caatgcagaa agcgcaggtg ttgagctgca ggcgcctttt ggcggcatga 250201 agcagtcgag ctcccactcc cgagaacagg gtgaggcagc gaaggacttt ttcacagcga 250261 tcaaaactgt ttttgtgaag ccgtaatggt gctggaaaga ggcgtgcgtc tctttcccgg 250321 tttatcacaa ccagcatatg attctctact ttgaaaagga gaagatacta tgaaaaaaga 250381 ctttgcgagt gttactccgg cgggcaaaaa aacgtccgtg cgctggttca tcgtgtttat 250441 gctgtttctt gtgacctcta ttaactacgc ggatcgagcg acgctttcca tcaccggaga 250501 ttccgtccag cacgatttgg gattggactc ggtcgccatg ggatatgtct tttctgcctt 250561 tggctgggcc tatgtcatcg gacagcttcc gggcggctgg ctgctggacc gttttggttc 250621 aaagactatc attgcgttaa gcatcttttt ctggtcgttt tttacgttgc tgcaaggggc 250681 gattggcttt ttctccgccg gcacagcgat tatcctgctg tttgcactgc gttttctggt 250741 tggtttatca gaagcgcctt catttcccgg aaacggcaga gttgttgcct catggtttcc 250801 aagctccgag cgcgggacag cttcagcctt ttttaattca gcacaatact tcgcaatcgt 250861 cattttttct cctttaatgg gctggcttac ccactctttc ggctggcatt ccgttttcgt 250921 tgtcatgggt attgcaggca ttcttctggc tgtcatctgg ctaaaaacgg tgtatgaacc 250981 gaaaaaacat ccgaaggtta atgaagctga gcttgcgtac atcgaacagg gcggcgggct 251041 gatttccatg gatgacagta aaagcaaaca agaaacagaa tcgaaatggc cgtatatcaa 251101 acagctgtta acgaaccgca tgctgattgg cgtgtacatc gcgcaatact gtattacgac 251161 tctcacctat ttctttctca catggtttcc ggtatatttg gttcaggccc gcggcatgtc 251221 tattcttgaa gctgggtttg tcgcttccct gccggcgctg tgcggatttg ccggcggcgt 251281 gcttgggggc attgtgtcag acatcttact caaaaaaggc cgttcactga cctttgcaag 251341 aaaagtgcca atcattgccg gcatgctgct gtcttgcagt atgattgtct gtaactacac 251401 agattcagca tggctcgtcg ttgtcattat gtcgctcgcg tttttcggaa aaggcttcgg 251461 cgcattgggt tgggctgtcg tgtcggacac gtctccgaaa gaatgtgcag gattaagcgg 251521 cggtttgttc aacactttcg ggaatattgc ctcaattaca acaccgatta ttatcggata 251581 cattgtcaat gccactggat ctttcaatgg cgcgcttgtg tttgtcggcg ctaacgcgat 251641 tgcggcgatc ctcagctatt tgctgctggt cgggccgatc aaacgggtcg tgttaaagaa 251701 acaagaacaa gaccccgatc aatcgttgcc tgtctaatat ttatgaaagc gctttataaa 251761 gggaggaaaa tgcatgagtt caccgataca agagcaggtt caaaaagaaa aaagatcgaa 251821 tattccctca atttctgaaa tgaaggtgat tcctgttgcg ggacatgaca gcatgctgct 251881 gaatctaagc ggagcacaca gcccgttttt tacccggaat atcgtaatct taacagacag 251941 cagcggaaat cagggagtcg gcgaggtgcc tggcggagag catattcgcc gcacactgga 252001 gctgtcagag ccgcttgttg tcggaaaatc tatcggtgcg taccaggcga tattgcaaac 252061 ggtcagaaag cagtttggcg atcaggacag gggagggcga ggaaaccaga cgtttgattt 252121 gcgcaccact gtgcacgccg tcaccgcact ggaagcggct ttgttggatt tgcttggaaa 252181 gtttcttcag gaaccggtcg cggctttgct gggcgaaggg aagcagcgtg atgaagtaaa 252241 aatgctcggt tacctctttt acatcggcga ccgaaatcgg acgaccttgc cgtatcaaag 252301 cgatgagcag tcagattgtg cgtggttccg tctgcgccat gaggaagcgc tgacgccgga 252361 ggccattgtg cgtcttgccg aatccgcaca ggagcgctat ggctttcagg atttcaaatt 252421 gaaaggcggg gtgctgcggg gagaagagga aatcgaagct gttaccgcat tatcgaaacg 252481 ttttccagag gcaaggatca ctcttgatcc gaacggggca tggtcattag aggaagctat 252541 tgcattatgc aaaggaaagc aagatgtgct cgcgtatgcg gaagatccat gcggggatga 252601 gaatggctac tccgctcgtg aagtaatggc tgaattccgc cgcgcgacag ggcttccgac 252661 tgcgacaaat atgattgcga ctgactggcg ggaaatgggt cacgcgattc agctccacgc 252721 ggtcgatata ccgctggctg atccgcattt ttggacgatg caagggtcgg tgcgggttgc 252781 gcaaatgtgc catgattggg gtttgacatg gggctcgcac tccaacaacc actttgatat 252841 ttcccttgcg atgtttaccc atgtggcagc agcggctccg gggcggatca cggcgattga 252901 tacccattgg atctggcagg acgggcagcg attaacgaaa cagccttttg agatttcttc 252961 tggctgtgtc aaggtgccgg ataagcctgg actaggcgtc gatattgata tggaacaagt 253021 ggaaaaagcg catgagatct atcggaaaat gaatttaggc gcacggaatg atgcgatccc 253081 aatgcagttc ctgatcagca actgggaatt tgaccggaag cgcccgtgtc ttgtgcgata 253141 agtttgattg taaatattgt catatccgct attttgtctt acaattgaac aactgaaggg 253201 agagttgttc gtgtacgaag gtttagagga tttgaaagtc gatacagtca atcggaaaac 253261 attagccaag caggtcatcg aacggattgt ccatttatta tcgagcggac agttgagggc 253321 cggagacaaa ttgccgacag aaatggaact gatggacatt ttgcatgtca gcaggccggt 253381 gctacgggaa gcactcagtt cacttgaaac gctgggcgtc attacgagaa aaacacgagg 253441 gggcacatat ttcaacgata aaatcggcat gcagccattt tccgtcatgc ttgctttggc 253501 cactgataat cttccggcta tcattgaagc gcggatggcg ctagaactcg ggctcgtgac 253561 aattgccgcg gaaaaaatca atgaggaaga gcttcagcgt ttgcagaaga cgatcgacga 253621 tattgccaac agcactgaca atcattatgg tgaagcggat aaagagttcc atcgaattat 253681 tgcgttaagc gccaataacc ccgtcgttga agggatgatt cagtccctgc tgatcaccca 253741 tgcgaaaatt gacagccaaa ttccgtacag ggagagagat gtaacggtcg aatatcacaa 253801 aaaaatctac gacgcccttg ccaaaagaga tccgtacaaa gcacattacc acatgtatga 253861 gcatctgaaa tttgtccgtg acaaaattct aaaaggaatg gatgaaaaat aatggtgagc 253921 aaccgcagtt gaaacgtaag agctgcggtt tttttaaacc aatttagaaa acgcttacta 253981 aaatatgagg agtgattttc atatggcgat gaacctcagg aagaaccaag ccccccttta 254041 catcaaagtg catgaaatag ataacaccgc gattattgta aatgatggag ggctgccaaa 254101 gggcactgtt ttctcatgcg ggctcgtact tgaagaggat gttcctcaag gccataaggt 254161 ggccctcacc gatctcaatc aaggggacga gatcgtgcgt tacggagagg tgatcggatt 254221 tgctgatgag acgatcaaac gcgggagctg gatacgggaa gccctcgtga gaatgcccgc 254281 tcctccggcg ttagacgatc ttcctctcgc aaacagggtg ccgcagccgc ggcccccact 254341 tgaaggatat acatttgaag gataccgaaa tgcggatggc agtgcgggga caaaaaatat 254401 cctcggcatc acgacaagtg ttcaatgtgt tgttggcgtt ttggattatg cagtcaaacg 254461 aataaaagaa gagctgctgc cgaaataccc aaatgtcgat gacgttgtgc cgctgcatca 254521 tcaatacgga tgcggcgtgg cgatcaatgc gcccgacgct gtcattccga tccgcacgat 254581 tcaaaatctt gcgaagcatc cgaacttcgg cggtgaagta atggtaatcg gattgggatg 254641 tgaaaagctc ctcccggaaa gaattgcctc cgaaaatgat gatgacattc tatcgctcca 254701 ggatcaccga ggttttgcgg cgatgatcca atccattttg gaaatggcgg aggaacggtt 254761 aatcaggctg aacagcagaa cccgggtgtc atgccctgtt tcggatctgg ttatcggcct 254821 gcaatgcggc ggcagtgatg cgttttccgg cgtgacggcg aaccctgccg tggggtatgc 254881 ggctgattta ttggttcgcg caggtgcaac ggttttgttt tctgaagtga cagaggtgcg 254941 ggatgccatt catttattaa cgccgcgggc tgtcagtgaa gaggtcggac aatcgctgat 255001 caaagagatg aagtggtatg acagctatct tcggcgggga gacgcagacc gtagcgcaaa 255061 cccgtcacca ggcaataaaa aaggcggatt atccaatgtg gtggaaaaag cgttaggttc 255121 ggtagcgaaa tcaggcacaa gccccatctc cggcgtgctc ggccctggtg aaagagcaaa 255181 gcaaaaaggc ctgctgttcg cggcgacacc ggcaagcgat tttgtgtgcg gcaccctgca 255241 gctggctgcg ggcatgaatt tgcaggtgtt tacgacaggg agaggaacac catatggcct 255301 ggctgctgcg ccggttctga aagtatcgac gcggcattcc ttatcagagc attgggctga 255361 tttaatcgat atcaatgccg gccgaatcgc gacaggagag gccagtatcg aagacgtagg 255421 ctgggaaatc ttcaggacga ttttggatgt ggcaagcggc cgcaaacaaa cgtgggcaga 255481 ccgttggggt cttcataatg atttgtgctt gtttaatcct gctccagtga cttgattcat 255541 gtttttatag cggaaagatg gaatatgctg taaaatgaaa atcagcgtat aggaaacgga 255601 ggggttacag catggcattc attagattcc gagtgacacg aattcaatag tgaacaactc 255661 tcgcctgaat gcgagagaat cgggatgaat ccgcctatgt atgagccctt atatggttat 255721 caaaaaagag ggtggcgtgc ctgccctttt ttgtgccttc aagcatccct tctctctact 255781 gcaggccgga gcatgagaaa ggggaaatgg gatgacaaac cttaacgaaa aacagcttat 255841 cactgagatt gtcgggcttg cacgcagcca aggtttgacg gttcattctg agaacgcgca 255901 attgaatgaa accggaatgg actttcaagt tgtatttgcc aaggacgaca caggtatgcc 255961 atgggtgctg cgaaaaccgc ggcgaagtga tgttgtggaa agagcatctg cagaaggcat 256021 aacgcttgcc tttctccgcg cgaatctgac tgctgatgtg ccggattgga gaattcatac 256081 accggaattg atcgcttacc ccatgttaaa aggaacgccg gctgctggaa ttgacttgga 256141 acaaaagcaa tatgtatgga atatggatca tcagccgccg tcagacgact ttgtccgcac 256201 acttgccgac atactggctg aattacatgg cacggatcaa atatctgctg ggcaatccgg 256261 aatagaagtg ataaggccag aagatttcag gcaaatgaca gcagactcta tggttgatgt 256321 gaagaataag cttggcgtat ctacgacgct ttgggaaaga tggcaaaagt gggtagatga 256381 tgatgcatac tggccgggtt tctcttcttt gatacacggc gatctccacc cgccgcatat 256441 ccttatcgat caaaatggac gtgtcacagg acttctggat tggacagaag cgaaggttgc 256501 tgacccagcc aaggattttg ttctttatca aaccattttc ggagaaaaag aaactgcccg 256561 tttgcttgaa tactatgatc aagcaggcgg ccgaatatgg gcaaaaatgc aggaacacat 256621 ctcagagatg caggcggcgt atccggtgga aatcgccaag ctagctctgc aaacacagca 256681 ggaggaacac atcaatatgg cgctggaagc acttggtgta acatcggatt aagaattgac 256741 ttcgtttcat gaaccgagta ttataaactc tacaaataat agaacggatt aacaatcgtg 256801 aggaagagca agtacgcatc agaatggagg ttcagagagt cggtggcagg tgtgaaccga 256861 tcctcccctg atgccgaatg ggcttctgaa ttgctttgct gaacggatag taggcgatgc 256921 cgggtttctc tccccgttac caagagagga gtatcgaaac ataggttttc tgtacttaga 256981 gtgaacggct gtatagctgt taataaaggt ggtaccgcga gaccctcgtc ctttgcatag 257041 gacgggggtt ttttgtgttt cttaaaggag gtgacggcca atgtacgatg gctggtggtg 257101 gcatagcaga tgagttagaa aggaggatat caaatggtca ttgcaactga tgatcttgag 257161 gtcgcatgtc ctaaatgtga aagagcggga gaaatcgaag gaacaccttg cccggcctgc 257221 agcggaaaag gtgttattct gactgctcaa ggatatacgc ttctcgattt tatccaaaag 257281 catttgaata agtaaaggag aaaagctgag ctgagatgag agcagaagag cagagtaaga 257341 ttcgtgaggc cgcagcaggt acgatttttt tgctgatcgg aacagtttgt tttgcgtcta 257401 aatcgatttg gataaaatgg gcataccaaa tgggtgctga gccagatgcc gtgctgctat 257461 acaggcagct gctggctgtt ccgctgtttt ggctgatttt tttaatatac cgtcctccaa 257521 tgccagacgg taagaaaaaa ggagacctat ggaaggcttg tggcgcggga gtgttttgtt 257581 tttttctgtc tcccttgctt gattttatcg ggctgaacca tgtatccgca atggttgaac 257641 gtatattgct gatgagctat ccgttgtttg tgtttggatt caccgcgtgt cgtgaccgga 257701 aaatgtcctc aattcaggac cttttcgcag ttctggcggt catgtttggg cttttcttgg 257761 cgctgggcgg ctggaatgct gagcttttcc aggcgaatat gattggagct gtattcattt 257821 tgttatcttc ggccgtctat gctggttatc ttgtcctttc cgggcatctc gtccatcaaa 257881 tcggagggat ccgtctcaat gcatacggga tgacagctgc tggagctgcc atgatgcttt 257941 acacagggat aaaatcggcg gctggcatga atacgccaat ggcagcatat ccgctttcta 258001 tgtatggttt gttcgcagta attgcagtcg ttaccacagt gattccattt gtgctaatgc 258061 ttgagggcat aaaacgaatc ggggcacagc gagccgccgc catttcaatg gcagggccta 258121 tcctgacgat tttctatgga gctttatttc tcggtgaacg gctcgggctc attcaagtca 258181 ttggatgcgg tggcgtattt tttgtcatta cgggcatgga atacaggaag ctgaaaacag 258241 gaaaaaaaga ataattttta taaaacacac acgtttttca attacaataa gtgtaattac 258301 gtgtgtgttt tttgattttg taaaggttag gtgaggagat gcagcgcata ttgcttgtag 258361 aagacgacca ctcaatcagt gaaatggtgg atcattattt aacaaaagaa ggctttggaa 258421 ttgtgcatgc tttcgacgga gaagagggca tccggctgtt tcagcagggt tcatacgatt 258481 tggtcctcct tgatatcatg ctcccgaagc tgaacggcat ggattttctg aaaatcatcc 258541 gggaaaaaag caatataccg gtcttaatga tttcggcaaa agatggagat gtggacaagg 258601 cattgggact gggctttggg gcggatgatt atatcgccaa accgttttcg atgattgagc 258661 tgacagcccg agtaaaagcc gcgatacggc gggcgacgca atattcggca gaggagccgg 258721 ctgtgaataa ggtgatccgg attcaccagc ttgcgataga tatagacaat gtttccgttt 258781 tgaaaaacgg agagccgctc cagctgacgt caacagaatg gcagctgctg tgcttatttg 258841 catcaaatcc taaaaaagtg tttacgaaag aacaaatcta ccgttccgtt tggaatgaag 258901 agtactttga tgatcagaac atcattaacg tacatatgcg gcggctcaga gaaaagattg 258961 aggatgaccc ctcctcccct caatatatta aaacgttatg gggcatcggt tataaattag 259021 gagagtttta gaatgacagt gctatgggtg gccgctgtca tcgctctggc gtgtctgaat 259081 gtgattcaat tcataatgaa aaagaagcgg gacgggaatc tggcttacac ggctgaccag 259141 cttagctaca tgctcagccg ggattcggca ggacaaattt tgcttcctac agacgatcat 259201 gcgctcaaag acttgcttgt taacatcaat cttatcgttg agaatcgtca gcagatcagc 259261 gcccaatttg ccaaaacaga gcaatccatg aagcggatgc tgaccaatat gtcgcacgac 259321 ctgaaaacgc cgttaacggt cattctcggt tatattgaag ccattcaaag tgacccgaac 259381 atgccggacg aagagcggga aagattgctg gggaagctcc gccagaaaac aaatgaactt 259441 attcagatga tcaattcctt ttttgattta gcgaaattag aatctgaaga taaagagatc 259501 ccgatcacca aagtacatat gaacgacata tgcaaacgaa atatcctgca ctattatgac 259561 gctgttcagt caaaaggctt tcaagcagcc atcgatatcc ccgatacgcc ggtgtatgcg 259621 caggcgaatg aagaggctct ggacagaatc ctgcaaaacc tattgtccaa tgcgattcaa 259681 tatggcgcgg ccggcaagtt aatcgggctg acgctgtctt atgatgagag gaacatcgcc 259741 atcaccgtat gggatcgcgg aaaagggatt agtgaaaccg atcagcagcg ggtgtttgag 259801 aggctgtaca cactggaaga atccagaaat aaagcatttc aaggaagcgg cttgggttta 259861 accatcacaa aacggcttac agaaaaaatg ggaggcatca tatccgtcca aagcaagccg 259921 tacgaacgga ctgcatttac gatcacattg aaacgcatga catattaatc gtaagaattt 259981 cttaaggttt gagaaataaa aatgacaggg ctcgccgcta caatagaaaa caggaaaaga 260041 gagggaagga gaaacaaagt tgacttatat cgtacaaaca aacgggctga ccaaaacata 260101 tcagggcaaa gaggtcgtat ccaatgtcag catgcatatt aaaaaaggtg aaatctatgg 260161 ctttctcggc ccgaacggcg cggggaaaac aaccattatg aaaatgctga cgagccttgt 260221 caaaccgaca agcggtgaaa tcatcatcct tgggaacaag ttcacccaca cgtcatatga 260281 ggtgctgggg aacatcggca gcatgattga atatccgatt ttttatgaaa acctgacagc 260341 tgaagaaaat ttagatctgc attgtgaata tatgggatac cacaataaaa aagccataca 260401 agaagtgctg gatatggtga atttaaaaca aatcgacaaa aaacccgtca aaaccttttc 260461 cctcgggatg aagcagcgcc ttggaattgc gcgtgccatc ctcacgaagc cggacctgct 260521 tattctggat gagccggtga atggtcttga ccctctcggc attaaaaaga tcaggcaatt 260581 gtttcaagtg ctgagcaaag agtacgggat gacgctgctg atctcaagcc acctgctggg 260641 tgaaatcgaa caaatcgcgg acacaatcgg cgtcattcgg gacggcaggc tgcttgaaga 260701 ggtatcaatg gaggatgtca ggggccagaa cactgaatac atcgagcttg tcacgccgaa 260761 tcagacaagg gcctgctttg tgctggagaa agagctgcaa ttaaccaact ttaaaatatt 260821 aaatgagaaa acgattcgaa tttacgaggc tgaagcctct caggctgcca tatccaaagc 260881 attgatttta aatgatgtag acattgaatc aatgaacaaa aagtatacgt cgctggagga 260941 ttattttatc aaattgatca acggcaatag catcagtgcg taaaggagga gagacacgtt 261001 gatgaatttg atcagaatcg aattaagaaa aatgaaaatg ggctggtata tcagaggtgc 261061 cctcattgcc aacgtgatca ttatgggttt tatgtggctg atcagttatt ccgaaaaagc 261121 cgatggcggg gtttcgttcc aaagtacgga tgaagcattc ctcatcatcg gcaccttcgt 261181 cagagcggta tttatcgtat ttggcgctgt gctgatcgta aaattggtga tttcggaata 261241 taaaaacaaa accattcttg tgatgttcac gtacccgatc agccgtaaaa agctgctcac 261301 cgctaagctc atgatcgcgg gcggactgac gtttatcacg attttacttt caaatatact 261361 catagccgcc ggtttctttt ggctgaactc gatctgccat ttcataccgg gagagcttac 261421 ttccgagatc atttctcaac aggcggtcaa aatggcggtt ttcgcttttg gcgccgctgg 261481 aaccagttta gttcccatct tttttgggat gcgtagacac tcggttccgg cgaccatcat 261541 ttcatctgta gtaattgtga tgctcatcag ctcaacaagt ccgggcttct cgatttcatc 261601 tgttgtgtat atcccgttat cgttagcggc attcggtttg ttcttttcct acatggcgat 261661 caggaatgcg gacaagcagg atgcgtaaac aaaggcgccc aatatgtata aaaggccgat 261721 gctgtcagca ccggcctttc cattatgagt ctgttcttgt ttcaagataa tgcttcttgc 261781 caatctcttt gctcatcata tagaaatgga agcaatattc accgattgcc atgacgatcg 261841 cgccgaataa agccgccaat gcaacttcac cgccagtcat ccccatagaa agcggcatgc 261901 ccatcagcca gatcacgaga aaggccaaac caaaatcagc caaagttgca atcatattat 261961 tccatttcgg caatacataa agatcgccca gcaaataaga aataacccct aacacaatcg 262021 tcattagcag cgtatcacca aacgtgaaac caaagcccag accaagcacc agatacaaca 262081 caataatcgt cataatacct ttaatagcga gcgctttcac atgtgtcatt acaattcctc 262141 cttttgtcat ttgatttgtt atgtataatt cctcaaatgt aaaaagttaa accttatttc 262201 ttttcggagg cgggtgcaaa tctgctgggg agaggtcaat gatgtgaatc caggaattga 262261 ggctgcggcg cttcgacagc ggaaacgtga agcttgtact gcaccggacg ctgctttgat 262321 gcccaacagc ccattatgtt tgctgttttt agatgaataa atttaaaaac ttctcctgtc 262381 cctccgtcat cacttctgaa gtaatgaaat atgatgaaaa gagatcaagg ggaggtgacg 262441 tgatggcggt cgtgagagca acgagtgcgg atgtcgattt gatggcaagg ctgctcagag 262501 cggaagcgga aggcgaaggc aagcagggga tgctgcttgt cggcaacgtt ggaattaatc 262561 ggctgcgggc gaattgctca gattttaaag gcctccgcac catcaggcag atgatttatc 262621 agccacacgc gtttgaggct gtgactcatg gatattttta tcaaagggcg cgagatagcg 262681 agcgtgccct tgcacgccgg tcgattaatg gtgaaaggcg ctggcctgca aaatttagtt 262741 tatggtactt caggccgcag ggggactgtc cagcccagtg gtataaccag ccgtttgtgg 262801 ccagatttaa gtcacactgc ttttatcagc cgacggcgga gacgtgtgaa aatgtatata 262861 acacatttta gagacaggac accgttcaaa ttgaacggtg tttttctttg aaaagatgca 262921 atgcaaaata ttcctgtgag ataatcaaag aaaaaagagc tgacggagat gacagaatgg 262981 caacaattga cctgcaaaag aaaagtgtaa agatcgtact ggagaaaaag cagttaacga 263041 aggtgacggc tcgtgttgga ctggttcttg atattacggg atcgatgaga ccgctctaca 263101 aaaacgggac ggttcaaaat gtggtggagc ggattttggc agtggctgat cagtttgatg 263161 ataacggttt gctggatgta tgggtgtatg ataatgaatt ttcccgatta aagccagttt 263221 cagaaaagga tttttcgggc tatgtcgatc gtgaaatttt aaataatgac cgcttgcata 263281 aattcggcag aaatgatgag ccgccagtca tgaaggacgt gctgcgcaaa tatgttacgg 263341 aggaaccgag ctcgtatcct gctttcattg tttttatcaa tgacgggggc tgtaaaaagt 263401 caatcaaacc gataattgaa gcttcttctg ataaaccggt gttctggcag tttgtcggca 263461 tcggaaacgg aaactttgat tttctcaata aactggatac gttagaaggg cgtgtcattg 263521 ataacacgaa cttcctgcat atcgaagaga ttgaccgcat ttctgatgat gagctttatg 263581 atgctctgct tgctgaattt ccattttggc tgaaagaagc gaaggaaaaa gggattgtaa 263641 gagaacaaga gcctcctgct gaaaagccga aaaagaaggg ctttttcagc agattgtttt 263701 cgaaataact gataaagagc actgagtcat tctgcgaaat ggctcggtgt ttttgttttt 263761 ttaagatcat gtgaagaaaa ataggccgaa tgggcggctt gcaaacgaca ggatatgcag 263821 aaaacgcgtc attcagccag ctttcggcat gtttcagcag caggcttgtg agggaagacc 263881 tgtttttaat gttcagcgct tacaatcagt tcacacttct tcacagtcgt ttaacaatga 263941 tttcctataa tggagacgat caatgaggag agaggggatc ttgaatggca tacgacagtc 264001 gttttgatga atgggtacag aaactgaaag aggaaagctt tcaaaacaat acgtttgacc 264061 gccgcaaatt tattcaagga gcggggaaga ttgcaggact ttctcttgga ttaacgattg 264121 cccagtcggt tggggccttt gaagtaaatg ctgcgcctaa cttctcaagc tatccgttta 264181 cattaggggt agcgtcaggt gatccgcttt ctgacagtgt cgtgctttgg acacgtctgg 264241 caccagatcc gctgaatggc gggggaatgc cgaagcaagc agtgcctgtc aaatgggagg 264301 tcgcaaagga tgagcatttc cgcaaaatcg taagaaaagg cactgaaatg gctaaaccaa 264361 gtcttgccca ttccgttcat gtggaagcgg acgggcttga gccaaacaaa gtgtactatt 264421 accgtttcaa aaccggccat gaactaagcc ctgtcggaaa aacaaaaaca ctgcctgccc 264481 ctggcgccaa tgtgccgcaa atgacctttg catttgcttc ctgccagcaa tatgagcacg 264541 gatattatac ggcctacaag catatggcaa aggaaaagct tgatcttgtc ttccatctcg 264601 gtgattacat atatgaatac ggcccaaatg aatatgtatc aaaaacaggc aatgtccgca 264661 cgcacaacag cgcggaaatc attacgctgc aagactatcg gaaccgtcac gctcaatacc 264721 gttctgacgc caatcttaaa gctgcacatg cggcattccc ttgggttgta acttgggatg 264781 accatgaagt tgaaaacaac tatgccaata aaatacctga aaaaggacag tcggttgaag 264841 cattcgtgct ccgccgcgcg gcagcatacc aggcatacta tgaacatatg ccgctccgca 264901 tttcctcttt gccgaatggc ccagatatgc agctgtaccg gcactttacg tacggaaacc 264961 tggcgtcctt caatgtgctt gatacccgcc agtacaggga cgaccaagcc aataacgacg 265021 gcaataagcc gccttctgat gaatcgcgca atccgaatcg gactctgctt ggaaaagaac 265081 aggagcagtg gctcttcaac aatttgggca gctcgacagc ccactggaat gtgctggcgc 265141 agcagatttt ctttgccaag tggaatttcg ggacaagcgc aagcccgatc tacagcatgg 265201 attcgtggga cggctacccg gctcagcgcg aacgggttat caatttcatt aaaagcaaaa 265261 atctgaataa tgttgtcgta ctgacaggtg atgtacacgc aagctgggca tcgaatttgc 265321 atgtcgattt cgagaagaca agttcaaaaa tattcggagc cgaatttgtt ggaacctcga 265381 tcacttccgg agggaacgga gcggataagc gagcggatac ggaccaaatt ttaaaagaaa 265441 atccgcacat ccagttcttt aacgactatc gcggatatgt ccgctgtaca gtgacgcctc 265501 accagtggaa agccgattat cgggtgatgc catttgtgac cgagccgggc gcagccattt 265561 ccacgcgggc ttcattcgtt taccagaaag accaaaccgg gttgagaaag gtatcatcca 265621 caacaatcca aggcggggtg aagcaatccg atgaggtcga agaggatcgt ttcttttcgc 265681 acaacaaagc ccacgaaaaa caaatgatta agaagcgtgc aaaaatcacg aattaaggag 265741 tggaaattat gttttcaaac attggaatac cgggcttgat tctcatcttc gtcatcgccc 265801 tcattatttt tggcccttcc aagctgccgg aaatcgggcg tgccgccgga cggacactgc 265861 tggaatttaa aagcgccaca aaatcacttg tgtctggtga tgaaaaagaa gagaaatcag 265921 ctgagctgac agcggtaaag caggacaaaa acgcgggctg aatgctgatg aggcagacac 265981 cgggtctgcc tcttttttta tgaaagggag ggcttttttg aatggataaa aaagaaaccc 266041 atctgatcgg gcatttagaa gagcttcgcc gccggattat cgtcaccctt gcggcatttt 266101 ttctatttct catcacggct tttttgttcg tacaggacat ttatgactgg ctgatcaggg 266161 atttggatgg aaagctggct gtgctaggac cgagtgaaat cctctgggtg tatatgatgc 266221 tttccggcat ttgtgccatt gcggcttcta tccctgttgc cgcgtaccag ctgtggcgtt 266281 tcgttgcacc ggcgctgact aaaacggagc gcaaggtgac gctcatgtac ataccaggtt 266341 tatttgcgtt gtttttggcg ggcatctcct tcggatactt tgtcttgttt ccgatcgtgc 266401 tcagcttttt gactcattta tcctccggcc actttgaaac gatgtttacg gctgaccgct 266461 actttaggtt tatggtgaat ttgagcctgc cgttcggctt cttgtttgag atgcccttgg 266521 tggtgatgtt tttaacaagg ctgggcatct taaatcctta cagactggcc aaagcgagaa 266581 agctttccta ttttctgctg attgtcgtgt ccatattgat tacaccgcct gattttattt 266641 ctgattttct cgtgatgatc ccgcttcttg tcctgtttga agtgagtgtc accctatcgg 266701 cgtttgtcta caaaaagagg atgagggaag aaacagcggc ggccgcttag tgcagcgtac 266761 cacccggtga cttcacatcc tcatcatatt gtgcggccgt aacagcggcg attctcaatg 266821 cccggacaat cgtgtccagg ctgaggctcg gcgctgtttt gtcgattgtt tgctgcggaa 266881 tgtaaggaat atgaataaaa ccgccgcgaa tgtgtgggga tgtccggcta atgtgatcca 266941 ttaacccgta gaacaaatag ttgcatacaa aggtccccgc tgtgtaggaa accgcagctg 267001 gaatgccgtg ttccttcatc ttagcagtca ttcgtttcac gggaagcctt gtccagtaag 267061 cggcgggccc atctggagaa atctcttcat caatcggctg atgtccttcg ttatcgggga 267121 ttcgcgcatc tgcaaggttg attgccactc gttccggtgt aatctgcatc cgtcctcctg 267181 cttggccgac acaaattacg atatctggct gatgtttttg aatggcttgg cgcagagtgt 267241 ccagagcgga tctaaagacg gttggaattt gttccgctgt aataatggct tcttctgtct 267301 cgaagccatt aagccgtttc gccgcttccc atgatggatt gacggtttct ttgtcaaaag 267361 ggtcaaagcc tgtgatcagc actttttttc tcattctccc atctcctttt tcttttattc 267421 tattgtttat ttatgggttt ttcatcaaaa taatgtaaag gagtgaatca taatggagca 267481 tttgccggag cagtatcgcc agttattccc aaccttgcag acgcatacga tgcttgccag 267541 ctgttctcag agcgcattgg cagagcctgt atcaagggcg atccaggatt attatgatag 267601 cctgctgtat aaagggacga actggaaaga agcgattgaa aaaacagagt ttgcgagaaa 267661 cgagtttgca aagctgatcg gggctgaacc ggatgaagtg gcgattgtgc cgtcagtttc 267721 tgatgcactg gtttctgtag catcgtcctt aactgcattt ggaaagaagc acgttgtata 267781 tacagatatg gattttccgg cggtgcctca tgtttggcag gcacactccg attataccgt 267841 atccgtcatt ccatcaatag acggcgtgct gccgcttgaa caatatgaaa cgcatatttc 267901 ggatgaaaca gtactgacgt gtgttcctca cgttcattat cgtgacggct atgttcagga 267961 tataaaagcg attgccgaga tttctcagag aaagggctct ttattgtttg tagatgctta 268021 tcaatcagcc gggcatattc ccattgatgt gaaggaatgg ggcgtagata tgctggcagc 268081 aggcacccgg aagtatttgc tcggcatacc gggtgtggcg tttctttatg tgagaaagga 268141 gctggctgac gcactgaagc cgaaagcatc agcttggttc ggaagagaga gcggatttga 268201 tggggcttat gcaaaagtcg cgcgccgttt tcaaacgggc accccagctt ttatcagcgt 268261 atacgcagct gcagcggctt tatcgctgct gaatcatatt ggggtttctc atatcaggga 268321 tcatgtgaaa acgatctgtg ccgatgcagt tcaatatgcc gctgaaaaag gcctgcagct 268381 ggcggcggca caaggtggga ttcagccggg catggttgcg atccgggatg agcgggcatc 268441 ggaaacggcg gggttgctga agaagaaaaa agtgatttgc gcgccgcggg aaaatgttat 268501 ccgtctcgct ccccattttt ataatacgaa ggaggaaatg cggcacgcga ttgatgaaat 268561 cgcggcgaaa acgatccaca agtaaacatg aaaaagcccc tgaacactag tcaggggctt 268621 ttcatattaa tgatctactt taacgcgttt cataaagaaa gcgccaatta aaccgataat 268681 ggcaacaatc attgcaaaca caaatgcgtg ctgtacgcct gctgtcaaag cttgcgggat 268741 gactgccgga tcggcagggt ttttaactgt actcatataa tcatgctggc ctgcagccat 268801 aatgctgacc gcaaccgctg ttccgatagc gccggccatt tgctgcagcg tgttcataat 268861 ggcggtgccg tctggataaa attcacgcgg cagttggttt aaaccgtttg tctgtgcagg 268921 catcatgatc atagaaatcc cgatcatcaa gcaggtgtgc aggatgataa tcagcacagc 268981 tgttgaagtg gtcgtgacat ttgagaagaa ccatagtaca acggtgacaa tcacaaatcc 269041 cggaatgaca agccatttcg gcccgtattt atcgaacaag cggcctgtaa caggggacat 269101 aaatccattt aaaataccgc ccggcaagag aacaagacca gatgcaaatg cagtgaggac 269161 taagccgcct tgcagataca tcggcagaag cagcatagat gacagaatga ccatcataca 269221 aatgaacacc atgatcacac ccaaaataaa catcgggtat ttgaacgcac ggaggttcat 269281 cataggctgc ttcattgtca gctggcggat tgaaaataag ataaggccga caacgccgac 269341 aatcagcgac acgataacag tcgggctgga ccatcccccg gagccttcac ccgcgttgct 269401 gaatccgaat acaatgccgc cgaagccaat cgtcgacagg atgatagaca atacatcgat 269461 tttcggcttt gtcgtttcag atacattttg catatatgcg ataccgaaaa caagcgccag 269521 cacaaggaat ggaagagaga tccagaaaat ccagtgccag ttgagatgct ccagaaccaa 269581 tcctgagaaa gttgggccga tggcgggcgc gaacataatg acaagcccga tcgttcccat 269641 tgcggcaccc cgtttatgag gcgggaaaat caccaagatt gtgttaaaca tcagcggcag 269701 taaaagaccg gttccaagtg cctgaacgat ccttgccgct aataaaaacg agaagctcgg 269761 cgcaagcgcc gcaatgaatg tacctaaaat tgaaaagata agtgacacgg taaaaagctg 269821 tcttgttgtg aaccactgca acagcagtcc tgaaacagga acaaggatac cgagtacaag 269881 caggtagccc gtcgttaacc attggacggt tgccgctgta atgttcaatt ccttcataag 269941 gtcggttaac gcaatattca gcgctgtttc actgaacatg ccgataaaac cggccaacag 270001 caaggaaatc ataatcggca tcactttgta ttgctgagat gctttagctg ttgtttccaa 270061 aatcatttcc cctctctatc aactgcatgt agtatgtcgt tttttttatc tcttcagcag 270121 gtcaggaatg cagctggaga tatgaaggag cggcgtactg ttttttgccg tcaaagataa 270181 aaggatgccg ccttcaatca tcgcgttaac cacagtgctg gcttcttttg cacggctctc 270241 gctgcagcca gtctgccgca gtttttcctc atacacagag gcccattctt tgtaggcttc 270301 atgacaggct tcgcgcaacg gttcgctttt caatgacgtc tcagccgcta gcaagcccac 270361 aggcaagcct tcaatgtctt ccgtacatga aaactggcag gagagctcct tcaaaaaggc 270421 ttgaatgcct tccgctggat cggtgcaggc ttccatgcag tccgcgattt tctgacggat 270481 atactccttc atctcattca cggcttcgat cgcaagctgt tctttacccc cgggaaagtg 270541 gtagtaaaga gagcctttag gcgcgccgct ttcctttata atctggttca gccccgtgcc 270601 gtaataccct tgcagctgaa aaagccgggt agctgccgaa aggattttct cacgggaatc 270661 tccataactc ataacattcc caccttactg aattgcaatc aaaaatatag tgactggtct 270721 attatcttga ttcaatcatc aattgtcaag aaaaattcat tgtatgaaaa gacaaaaaaa 270781 gaaggatatg acaacaaaaa atactgagag aaaagctgac tgatcttttg actgaataga 270841 taaaatgtac aatgattaat catcatatgg atgtaaggag agaaatagat gaaaaaacaa 270901 cgaatgctcg tactttttac cgcactattg tttgttttta ccggatgttc acattctcct 270961 gaaacaaaag aatccccgaa agaaaaagct cagacacaaa aagtctcttc ggcttctgcc 271021 tctgaaaaaa aggatctgcc aaacattaga attttagcga caggaggcac gatagctggt 271081 gccgatcaat cgaaaacctc aacaactgaa tataaagcag gtgttgtcgg cgttgaatca 271141 ctgatcgagg cagttccaga aatgaaggac attgcaaacg tcagcggcga gcagattgtt 271201 aacgtcggca gcacaaatat tgataataaa atattgctga agctggcgaa acgcatcaac 271261 cacttgctcg cttcagatga tgtagacgga atcgtcgtga ctcatggaac agatacattg 271321 gaggaaaccg cttatttttt gaatcttacc gtgaaaagtg ataaaccggt tgttattgtc 271381 ggttcgatga gaccttccac agccatcagc gctgatgggc cttctaacct gtacaatgca 271441 gtgaaagtgg caggtgcccc tgaggcaaaa gggaaaggga cgcttgttgt tcttaacgac 271501 cggattgcct cagcccgata tgtcaccaaa acaaacacaa ctacaacaga tacatttaaa 271561 tcagaagaaa tgggcttcgt cggaacaatt gcagatgata tctattttaa taatgagatt 271621 acccgtaagc atacgaagga cacggatttc tcggtttcta atcttgatga gctgccgcag 271681 gttgacatta tctatggata ccaaaatgac ggaagctacc tgtttgacgc tgctgtaaaa 271741 gccggagcaa aggggattgt atttgccggt tctgggaacg ggtctttatc tgatgcagcc 271801 gaaaaagggg cggacagcgc agtcaaaaaa ggcgttacag tggtgcgctc tacccgcacg 271861 ggaaatggtg tcgtcacacc aaaccaagac tatgcggaaa aggacttgct ggcatcgaac 271921 tctttaaacc cccaaaaagc acggatgttg ctgatgcttg cgcttaccaa aacaaatgat 271981 cctcaaaaaa tccaagctta tttcaatgag tattgaagaa aagaaggcga ataagccttc 272041 ttttttttgg ctttttagga ccaataatga cctctgaatc ttaaaatttc tttaaaaata 272101 agccaaaatt accctttact taattaattt ggtaacgtaa tataattgga gaatttgtta 272161 caaaaaaagg aggatattat gaaatttgta aaaagaagga tcattgcact tgtaacaatt 272221 ttgatgctgt ctgttacatc gctgtttgcg ttgcagccgt cagcaaaagc cgctgaacac 272281 aatccagtcg ttatggttca cggtattgga ggggcatcat tcaattttgc gggaattaag 272341 agctatctcg tatctcaggg ctggtcgcgg gacaagctgt atgcagttga tttttgggac 272401 aagacaggca caaattataa caatggaccg gtattatcac gatttgtgca aaaggtttta 272461 gatgaaacgg gtgcgaaaaa agtggatatt gtcgctcaca gcatgggggg cgcgaacaca 272521 ctttactaca taaaaaatct ggacggcgga aataaagttg caaacgtcgt gacgcttggc 272581 ggcgcgaacc gtttgacgac aggcaaggcg cttccgggaa cagatccaaa tcaaaagatt 272641 ttatacacat ccatttacag cagtgccgat atgattgtca tgaattactt atcaagatta 272701 gatggtgcta gaaacgttca aatccatggc gttggacaca tcggccttct gtacagcagc 272761 caagtcaaca gcctgattaa agaagggctg aacggcgggg gccagaatac gaattaatga 272821 aaaacaaaac cttgaagaat gctattcttc aaggttattc tgctttcagc acaatggttt 272881 tcgcagccat atcatgaacg gtttgttttt tcttcgtaaa tgcggcagtc aaatagatca 272941 ggcgggagaa cacatgcacc cacgctatca ggtaacggac aatggcttgc gggaaggata 273001 tttttttata tgtttcgtcc ctcacgattt gcagcccgat gatttttttg cctagtgtgc 273061 ccttccaatt tgtcagcggc atcagcaaag ggtacacaat cagcatcaat atggcgacaa 273121 taatgacacc ggcggaccca tcgccaaacg taaatccggc tgccaaaatc actgctgcgg 273181 caatgattac atcaagtaaa agagcgcagg cgcgcagcat gaaaccagct agttccaata 273241 gaaacactcc ttaaaatgtt aaataaacac ctaatgattg taaaaaagaa gggcctaaag 273301 tgggaatagg tgataagcct taaatcacaa aagttggtga aaatgtcata ggtaaattgg 273361 cataatcagc cagcttatca cattaccaaa ttctttttta gcccgaaacc aagccctcag 273421 aagttatttt tgttaaaata gaaaagttac aacagaattc ggagggttta ttgtgggaaa 273481 agtgaaacga aatgcccctt gcccatgcgg cagcggcaag aaatataaaa aatgctgcgg 273541 aagtaaagtt gtcgacttcc cggcggaact agcggcaaaa gaagcgaaac aaattcagga 273601 agacttagtg gagtatgcct tcacagtaca tagagaaagc atttcaggct ttatcaacca 273661 gcatgatttt ctttctgcta tggacagaca gacgaaagac atcagcgtat ttaacttagg 273721 aatctgggga atcttcttcc acccgcttgc tggtgagaag acaatcttcg aagagtacct 273781 tcagaaaaaa ggcgattcga tcactcgtcc gaaaacgcgt gagatcgtag aatcatggca 273841 gagcatgacg cctgctttat tgctgctgaa ggacctgaag gaaggcatca ttcactttga 273901 agatgtcatt acggcaaaac aattcgaagt ggaaatggac gccagcaatc aagaccttcc 273961 tccagtggga agcctgattc ttggataccc aatccacgaa gcggaaaaag cagaattctt 274021 catgcagttc acgatcttcc cggtgaagag aacagaagcg ctgatcagca aggtgaagaa 274081 atatgcggat gccgctgtga aggacggcaa aacgccggag gacttcatga agcaggaatt 274141 caacaacgtt ctgttcgcgt tgttagctga gaaagatgaa gagccacaag cagagaaagc 274201 ggaagtaagc actgttgagt gggcaaacga cttggagaaa gaaaccgctg cggctattga 274261 agaaggcatg agcggggaag agtatccgac tgaattgatc ccagctgtta ttgacatctg 274321 gaaaacattc tgcgagaaaa aatcacctgt catcagaaag ccggaagctt ttgcggcggc 274381 agttgaatat tatgtaaacg caatttctct taacggcgcg tccgtttccc aggctaaact 274441 ggcgaaaaaa tacggcgtta gcgcatcaac gatttccagc cgttacaaag aaattgaaag 274501 cacgctgcaa gatgaagcag atcgttttgc acaagcgtta tcctcataat ggaaaaaacc 274561 ttgaaaagcc aggcttttca aggttttttt atttctgaaa cggaattttg atttctaacc 274621 ggaagatggg gtggcggtag gtaaaatcca gcctgccaaa agcgcccttc accagttttt 274681 gaatgatata tgtgcccatg ccttcatgag cgccgttttt cgttgagcgg ccaaacgatt 274741 gataaattgt atcgagcact tttgggtcca tcccgggagt gctgttttca caagtcagta 274801 cataaagccc gctgcgcagt gaagtctcca gtttaatctc tgctttttct cgggcctccg 274861 ccgcgctgtc gagcgcattt tctaatatgt tgccgaccaa gctgacctga tcagcaggcg 274921 aaaacggaag ggaagaaagc ggtgtatgca tatgcagcga aacactcaca ttcgaggcgc 274981 gggctttttc taaaaaatca taaagcaccc ctgcaacgta cgcgttctct cctttcaaaa 275041 aacggtcata ttggctgtat tgatccgccc agttttgaat atatgcttgt gtatctgcct 275101 tgggctgagc tgatttgatt gcagtgatat gtttcattgt gtcatgattc cggcttctga 275161 catcaatcag catttgattg gcgtgctgtt cagcttgagt cagcttatca atttgatcag 275221 aaagccttgc ctgcaaagca gactgtccga tacggagccc ttcacaccct gcaaatatcg 275281 cgattacaca taataccggc atgatgtctg tgccaatcaa caccactccc accgacatca 275341 cttgaatcac cgcaatccac gcacaaagcc ctgaggaaca gtgtttccac acccgcttcg 275401 tattccaaat gtacaatcct gcagcagctg cgcctaaagc agcggcgagc caagaggcgg 275461 ctgtgctgtg tgaaaaagca gcagctccct gataacatat gaaactaaat aaaatcagat 275521 aaagacattg aaaaagggta atcacgtact aaactcctca aaaatagtag ttttgaaaat 275581 aatcaagctg ctgcttagtg atcatcgctt ttttagacgt tccctcaaag gaaactgtga 275641 atgaatgctt ggtataagcg gaaaaatgct ttatgtaatg aatgttgata ataaaggaac 275701 gatgcgaacg aagaaaatct ttttcgggca ggtcgccttt aatatcattt aatgtttgat 275761 acgtttgcac ctcttcggcg gttgtcacaa tcgtcgtcga acgtcccgtc cgttctgcga 275821 aaataatatc cttcttttgc aggacgtgca tttcagactt ttgctttatc aatatacgcc 275881 cattcaaact cgtttccgtt ttctttttca agtaccggtc gaaggaagcg gccagacggt 275941 cggcatagta cggcttcata atataatcat ggacgttcag gtcaaaggcg tgaaccgcat 276001 aaccgccgtg gccggtaaca aaaatcacat ccacatcaag tgaatgggat ttgatcaaat 276061 cagcaagctc gtagccagac atatggggca tctcgatatc ggcaagcagc agatcaatgt 276121 ctccgttctt tacccgcctg taggcttcct tcgctgaatc ggtggaaaag acaatttcga 276181 cgtcctgcat tctggacacg atcgcttcta acttctctaa atctactcga taatcatcta 276241 caagtccgac ttttaccatt atcattcccc tagttacata gaatcatctt tattctatcc 276301 catttcacga cataaaaaga actcttcgcg acaactttat ccaactaatc cagcttttcg 276361 tatatagtca ttactagaaa taaagataag ggagattgtg acatgattac actgaccgat 276421 tgcagccgca ggtttcagga taagaaaaaa gtagtcaaag cggtgcgaga tgtaagctta 276481 acaattgaaa aaggagaagt cgtcggcatt ctcggagaaa acggtgccgg caaaacgacg 276541 atgctgagaa tgattgcttc cttgcttgaa ccatcacagg gtgtaatcac agtagacggc 276601 tttgacacgg tcaagcagcc ggctgaggtc aaacaaagaa tcggtgtctt attcggagga 276661 gaaaccgggc tttacgacag gatgaccgct aaagaaaatc tccaatactt cggcaggctg 276721 tatgggctga accgccacga gatcaaagca agaatagaag atttatcgaa acggttcggc 276781 atgcgcgatt atatgaaccg gagagtgggc gggttttcga aaggcatgag gcagaaagtc 276841 gccattgcca gagcgctgat tcacgatccg gacatcattt tatttgatga gccgacaact 276901 gggcttgata ttacgtcaag caacatcttc cgcgaattta tacagcagct gaaaagagaa 276961 caaaaaacga ttcttttctc cagccacatt atggaggaag tgcaggcgct ctgtgacagt 277021 gtcatcatga ttcacagcgg agaggtgatt taccgagggg cgcttgaatc actatacgag 277081 agcgagcgca gtgaggattt gaattacatc tttatgtcta agcttgtcag ggggatttct 277141 taaatgctga gccatattta taaaaaagaa atgatcgacg ctttacgcga cagaaaaacg 277201 atattactca caatcttagt gccgatgatt atgatgcttg gacttgtctt tttttatgaa 277261 agcatgctgt ccgacaaagg ggagcagtac acgctggctg tcggccattc gcttccgccc 277321 gcactggaaa gcaagcttaa tgagattgac gaaatcagcg taaaaacatt tgcaaagcct 277381 gaagaggcag ttgatgaagg aaaagcagat gcctatctga acgtcccgaa agagttcgac 277441 tcatatgtca acagcatgac accttttaag gttgatgttt acggcaattc aatcgatcaa 277501 gggtcgtcaa atgccatgca gcttgtgcag tctgccttag atcagtacaa aaatgaaatt 277561 gtgcagcaac gtttaacaaa taagcatatt gatcaatcgg tgatccagcc gtttacaatt 277621 cagcaaaagg aagcggatga ggagaaaggg acttccgcta ttatgctttc cgccattctg 277681 cccatgctga ttctgacttc cattgtttcc ggcgcaatgc cgatcgctct tgatatcatg 277741 gccggtgaaa aggaccgaaa gtcaatcgag gcgctgctat taacgccagt cagcagaaac 277801 aaagtgctgg tcggcaagtg gcttgcggtt tccacttttg gcgtggcttc aggtgtattt 277861 gctttggtgt ttttgatttt gtccaccgtg ttatttaccg aaaatttaaa aacggccttc 277921 cagctgggag atcatatgtg gagtgtaatc ggcgcttcag ccttaatcat tgtgctctct 277981 gcattgctga tatctgcgat ggagcttttc atcagcatca tgtccagctc ggtaaaagaa 278041 gcgcaaagtt atatgtctct cgtcgtcttt ctgcctgtgt tcccgatgtt tttcatcttc 278101 agcaaggcac cgaaccaatt tgacttatca tactttctca tcccgtttct gaacctgcat 278161 gcgttattta aacagctttt attcgggatg gttgacccgg ctaccatttt gtctacgtca 278221 ggaaccatcg ccgtgctcat cgccatcttc tttttactag ccagagcctg cttcctgaaa 278281 gacaaatggg ttcttccaaa ataaacttgc gaaaggagaa atacactttc tcctttttgt 278341 atatcctgaa aaaagaagga aaatagaaaa aggatatcta atacaaaaag tgaccctgca 278401 ctatttttca tcaaaattgg tttcaaagga gaaggaacaa tggatcaaac acgtacactc 278461 ggcaaaacga agctgaaggt gaagcggatc ggattcggcg cgaatgcggt cggcgggcat 278521 aatctatttc caaatctaaa tgatgaaaca gggaaggatt tagtgcgcac ggcattggat 278581 ggcggcgtca attttatcga taccgccttt atatatggat tggggcgatc tgaagaatta 278641 atcggcgaag tcgtacagga acgcggcgtg cggaatgagc tcatcatcgc caccaaagga 278701 gctcataaag aagtggacgg cagcattgaa ttagacaata gccgggagtt tcttcgcagc 278761 gaggtggaga agagcctgaa gcggctgaaa acagattaca ttgatttgta ttatgttcac 278821 tttccggatg gaaaaacacc tctcgctgaa gtggcgggca ctttgaaaga gctgaaggat 278881 gaggggaaaa tcaaagcgat cggcgcttcg aacctcgatt atcagcaatt gcaggatttt 278941 aatgctgacg gctatttgga ggtcttccag gccgaatatt ctctcataca gcgtgatgcc 279001 gagaaagagc ttcttccata ctgtgaaaaa caaggcatct cctttattcc ttactttccg 279061 cttgcgtccg gactgctgac aggaaaattc acgcaagaca cagtctttga tgatttcaga 279121 aaggataaac ctcaatttca gggtgaaacg tttatccaca atctcaaaaa agtagataag 279181 ctgaaagcag tagcggagga aaaacaagcg gatacggcac atgtcgcctt ggcgtggctg 279241 ttaacgagac cggcgattga tgccattatt ccaggagcta aacgaccgga gcaattacag 279301 gataacctga aaaccttgaa cattgaactg accgaagatg aagtgaattt catcagcgac 279361 attttcaaat aaaaaaggaa atagccgtca tggctatttc cttttggtgt tttattcttt 279421 gatgaatgct tcgactaatt ctgctgctct gtaatcatcc atatcaagct gccattggtc 279481 gatgtcattt ttcttcattt tcacttcaac tgttttttca gatgaagcag gtccaagctt 279541 tttgaattcc tcaggataga cttgaagcgc gtatttcact gcctcttcat agctggcact 279601 agagttttta ctgtagtagt ctttcacttt gtcttcgatg cggtctgaaa gagaagatgc 279661 atctacaggt ttaactgtgg cttcaacaat tgcttcgtct ttagagattg aagtcgtttt 279721 tgcttgaatg gaagagtttt tgcttaatcc ctctttaatg ccgttcacga tattatcaag 279781 cgctttgctg tccgcatatg tgctggaaag gccggaagct gagagataac cgtctttggc 279841 tgattcatta aaatcattta caatttcatt tttgttagcg ccggtgattt tttcgaaatc 279901 ggcgttatct ttgccgaaaa gaaggacatc aacataagct gataacgctt ttgcagaatc 279961 ttggagctta tctgccgtcg ccaggatttt tttgtctttt ccgtcaattt taaaagtaac 280021 tgattttggc tttttatcac cgtaagattc cggcgtatag ttaagctcgt attgcttgcc 280081 tttatctaca acgaagaaaa gatttccttc aacggatttg tcagcgttaa tcgtgctgcc 280141 ctgaagcttt tcgctatagt cttcagggtc tgtgtcagac attttggtat caccttgata 280201 caatgtgaaa tccatactgt ctacattcag cgggtctttt cctgtgtttt tcaccgcgac 280261 attgactttt aacacaagct ggtcatctga agtggactta tcatatttag acggaagtgt 280321 gtaagagaca tccttgattt tgacttgagc tatatctgag cttttttctg tttctgattc 280381 tttcttctcc gcgcttgttt tgctgccgga acaagcagct gtaaacatca tcagcagaag 280441 aattaggaaa acagcgtacg tttttttctg aaacattcat ttttcctcct caaatggttt 280501 aggaaagggg agtcttttgt ctttgagaaa tggatctttt tgaatggatt agcatcatat 280561 aaccaaaaaa atcagttctt ttctcacggt tttcaccgga ttttctggaa actccgccct 280621 cctttgtcat gaatggacct ataaaaagtt acaacggaat taattttaag attattagct 280681 tttatattga ataggttcat catcctattt ttggtgaaaa atgttctggt aaaactggta 280741 aactcagaaa actgtgtatt ttagactatt actttttgat tagttggagg gaacttaaga 280801 aggatgaaag gggccgcctt tgtgaagaaa gagggactga aacaaaaagc actggaaatc 280861 ggccgggtgc cgacacactt aaaactggaa attgaagatt atggcggtga tgataaaaga 280921 gctcattttt gttgggcaga tcctcaggat gagaataccg gcattatcgt ggagcttgga 280981 ccggacggag agctggaatc cctttcccgt gatattgagc ctgaaagcgg agaaaggctg 281041 tctgaggaga aactagagga tatcatgcgc caatttgtcg agactcatca tccgggggca 281101 ctctctgcct ttgttcgtga agaaaatgac cgtgcatacg gcgataaagt gagattttca 281161 tatgttcaaa tggaggctgg gcttcctctc cccatgagcg gatttatggc tgatgtttcc 281221 ttatcaggtg agattgttta cttccgttat tacggcgaag cgggcagcat catcaagcca 281281 aagcgggtcg cggatgttga agaggcactt gcctttatca agaaggacgt ggagttcgac 281341 cttttgtttg aggttctcca tcgttctgtt tacaaaaacg gagatgatca gccgcatttg 281401 gtgtacgagc ctgaaggtag ggcgattacc gtacctgcgg atttggttca agaagaacaa 281461 gcagttgatg atgacgatga ttacagggag ccggagagct ttcctctccc tttattcgag 281521 ggcatccgcg aaaaggccga tcctgacagc atgattggta ttgaaaatgg gtttgtcaaa 281581 gagcgggaag cggatttggg agatgggaga attggaatcg tttggcggaa tccggatgac 281641 cctgtgtatc agccggcgga taaaagcatg gacagctggt ttaagggacg gactcatcaa 281701 gtgctgaaaa ccatctataa caaagaaacc ggaaaactcg aaggcgtcat gtcatttatg 281761 gagaaaaaag ggccgctgac agtaaccttg gcagagtgtg aaaaaatcgc gcttcgcttt 281821 ctatttgctt tatttccgaa tgccgatcaa tattttagga tcagatacga cgaaaaagat 281881 gaagaagaaa acgcagtcgc tggttttacg tttgaagcgc attgtcacgg agttccgctc 281941 cgatttgggc agatcagaat ttgtgtcagc cgccagacag ggtatatcac cgtttatatg 282001 ggaccggata ttgacccaaa taagctggca accattgatc ctgtgccggc tatttcagtt 282061 gaacaagcca agtctatctt ttggcagcat tttaaagttg agcttggctg ggaaagagag 282121 tacggggatg atgaagaaca cagctaccgg ctcgtctata agccggtgta tccgcatttt 282181 atcgatgcac atacagggga gcctgtcttc agcatatggt gaaacagcca aaagtcacgc 282241 aattgcctca gatatagaag agagtatgtg atgaaagtaa cagaaagaat ctcaaaaaac 282301 aatgacaata atagaaaagg acctttcttc actttaaatg aagaaaggtc tttttatata 282361 ataaacagga ttctctttgt cgtagactct ttgaaaggga tgacttcatt ggttaataaa 282421 cagctgaaaa agaaggcgca ggagatcgga aatgtaccga cgcattatga gcttgagata 282481 gaagattacg accaaaagca aaagaagtac gggcaggcat attttatctg gaaggaccct 282541 aaagatccgg aaaagcacat tacagttgaa cttagaaatg acggcgcctt gctcaccttt 282601 tcaacaactg tccactccga gacagacaaa aaacttccag atgccgagct gaagctgacg 282661 gctcttcagt ttgccgctgc caatcatccc ggcacattta tgaattttca ttttcaaggc 282721 aaggaagaaa gggggcagca catccggttt gtctatacca aaatggagct ggggcttccg 282781 attcccaatt caggcttttt aattgatatg acacgaagcg gtcagattgt ccactttcta 282841 tattacgggg aagggcataa agccgaagtt ccgacggaat ttgtagcaaa agagaaggtt 282901 gtatcccatt acttaaacac aatgtctttt gagctgatgt acgatgtcat tgatggcgaa 282961 caggaaccaa ggcttgtata tgaaccgatt ctaccgggat acagctatcc cgcagatgta 283021 gacgaaattg tgcccgacca gcatatcgca gatgaaagaa tagaaaacac ggcgccactg 283081 ccgccgcttc agaacaagga agaagttgat atatttgcct tgctgggttt tacctctgat 283141 atgcagaaag tcagtgaaag agactttgga gaacaaattg gaagcacgtg gcgcaggggc 283201 gctgcgccgg agcgtaagga tttaagcata ggaagctatt ttgaaacgag aaataaaaat 283261 acaatcaaaa tgaagacgga taaaagaacc ggaaaattaa aagcagcgct ttcttttatg 283321 gactggcgga acaacctcca atgctccacg gaagaatgcc aagagatagc gcttcaattt 283381 ttgtatgccc tctatccgag agcggctgag tttttcaggg tgaatcccgt ccgaattgat 283441 gaaagaggga gagtccgcaa ccatttttct gtctggtata aaggagtgcc gctgcggttc 283501 ggcgctgccc gcatcattgt caatccggaa actgggttga ttgacgcttt tatggcgcct 283561 gatattgaac ctgaacaatt ggaagcgata aatcacaggc cggatgtttc cgctgaagaa 283621 gcgaaagaag catttttagc cgcttttgat gtgaaactgg aatggcagcc tgattttaca 283681 gcaggcagtg accagcactg caaacttgtc tataagccgg tttacccttc ctatattgat 283741 gcgcacataa ggaaaaagaa aaggctgtga ggggtgtcta gttaggaatc atctccaagt 283801 gggggtagtc cttgaatcgt ttccaatccc cgccccattc gaaaccgagt gtcttagcga 283861 tctcgacaac ctccagccaa tctgattttc cgttttgatt gccgtcatat tccatatccc 283921 atatgatgct gccatccttt ttttgaaggg cgaaatcaat cgctaaacca tagttatgat 283981 acgattcccc tcctcttgca taggtgacaa tattcccttt ttttgtacgt ccctgtttat 284041 ataattcatc ttgttcctta aaggacctga atccttcagt aatgacgacg tcaatgcctt 284101 tattcgctgc agcggctttg agtgcatcgg cattctgctt cacaatcgga tgaagatccg 284161 aggggacagg catgtcctgc aaggcgtttt gagaatgcca ttcatgccga atataactaa 284221 aacaaagatc tagaagaaat agaatacata agataacaaa tgtttttgcg ggtaagttca 284281 tatcggtctc actttctcaa gatgtgctga atgttaacgc ttttaagtga ttgactctct 284341 ctaaaagcga acagctatga taaaatataa cataaatagt agcaggagga aggaggcaga 284401 ccgatgagag caaagattcc atcagaagaa gtagcagtaa agctgaatga atggtacaag 284461 ctcattcgcg catttgaagc agatcaagca gaagcgttaa agcaggagat tgaatatgat 284521 ttagaagata tggaagagaa tcaggacttg cttttatatt tttctttgat ggaattccgg 284581 catcgaatca tgcttgataa gctgatgccg gtgaaagaca gcgataccaa gcctccgttc 284641 tctgatatgc tgaacgaaat tgaaagcaat cagcaaaaac tcacgggctt actggaatac 284701 tacttttatt atttcagagg aatgtacgaa ttcaagcaga aaaatttcat attagcgatt 284761 gaccattata aacatgccga ggaaaagctc gagtatgtcg aggatgagat cgaaaaagct 284821 gagtttcttt ttaaagtcgc agaagtgtat tatcacatca aacaaacgta tttttccatg 284881 aattatgcga gccaggcgct tgatatctat acgaaatatg aactgtacgg tcgccgccgg 284941 gttcagtgtg aatttatcat cgccggaaat ttgaccgatg tgtatcatca tgaaaaagca 285001 ctgacccact tgtgcagcgc tttagaacat gccaggcagc ttgaagaagc gtacatgatc 285061 gctgctgcct attataatgt cggacactgt aagtacagtc tgggtgatta caaagaagcg 285121 gagggctatt tcaaaacagc cgccgccatt tttgaggagc acaactttca gcaagctgtt 285181 caagctgtat tttcactgac ccatatctac tgtaaagagg gaaaatacga caaggcagta 285241 gaggcttatg accgcgggat aaagagcgcg gctgaatggg aggatgacat gtacttgacg 285301 aaattccgcc tcattcatga gctgtatctt ggaagcggcg acctgaacgt gcttacagaa 285361 tgctttgacc tgctggaatc caggcagctt cttgctgacg ccgaagatct gctgcatgat 285421 acagcggaac gtttcaatca gttggaacat tacgagtccg ccgctttctt ttaccgcagg 285481 ctgatgaata ttaaaaagaa gcttgccgag cagcgttttc aataggaaat ggcagagaac 285541 tacaggttct ctgctttttt tgtgctgttt tcaactcgga aaaacagggt attttccact 285601 gcatagtgag aaacagagga ggatatcaag tatgtacaaa gatttaaccg gaaaaacagc 285661 gattgtgaca gggtcttcaa aaggaatcgg gaaagccatt gcggaacggt tcggaaagga 285721 gaaaatgaat gttgttgtaa attaccacag cgacccgtct ggagcagatg aaactctgga 285781 aatcattaag cagaacggag ggaaagccgt ctcagttgag gcggacgtgt caaaagaaga 285841 ggggattcag gcgctcttgg acacagcttt agagcatttc ggcacgctcg atgtgatggt 285901 aaacaactcc ggttttaacg gcgttgaggc gatgccgcat gagatgagtc ttgaagattg 285961 gcagagagtg attgatgtca atgttaccgg aacctttctg ggagcgaaag cagcacttaa 286021 ccacatgatg aaaaacaata tcaagggcaa tgtgctgaat atctcaagtg ttcatcagca 286081 gattccgcgc cctgtaaacg ttcagtattc cacatccaaa ggcggcatca agatgatgac 286141 ggaaacgctg gcgctcaatt atgcggataa gggaatccgc gtcaatgcga tagcgcccgg 286201 caccattgcc acagaatcaa atgttgatac gaaaaaggaa gagagcaggc aaaaacaatt 286261 gaaaaaaatc ccgatgaaag ccttcggaaa gcctgaagaa gtggcggcag cagcagcttg 286321 gctcgtatct gaggaagcaa gctatgtgac cggcgcaaca cttttcgtcg acggcggaat 286381 gacactttat ccatctcagc ttgaatagaa gacaaaacag ggggattgcg ggatgaaaac 286441 agactggtgg aaggatgcag tggtgtacca aatttacccg agaagctttc aggacagcaa 286501 tggagacgga attggggact tgcgggggat tatttcccgt cttgactaca taaaggagct 286561 cggggcagat gtgatttgga tttgcccgat ctatccttct ccgaatgttg attacggcta 286621 tgatgtgaca aaccataagg cgattatgga ttcttacgga acaatggacg attttcacga 286681 gctgctggac caggtgcatc agcggggatt aaagctggtg atggactttg tgttaaatca 286741 cacctcggtc gagcatccgt ggtttaaaga agcggagctg gacaaaaaca gcaaataccg 286801 tagctattat tattggcgtc ccggcacaaa gaacggcccg ccgacggact ggctctcaaa 286861 ctatggatgc ccggtctggc aatacgaaga gcacaccgga gaatactatc tccatatgaa 286921 tgccgtcaaa caagctgatt taaactggga aaatcccgaa gttcgccagg cggtgtatga 286981 catgatgaaa ttttggctcg ataaaggggt cgacggtttg cgaattgatc agctccatct 287041 catttctaag aaagaatatc ttccttcgta tgaggactat atcaatcagc aggcagagcc 287101 gaagcccttt cagccaaatg gcgaacgaat ccatgactat ttaaaagaaa tcacagatga 287161 agtgttttct cattatgatg tcatgtctgt cggagaggtc ggcagtgtca caccggaaga 287221 aggcctgaaa tatacgggaa cagataagca tgagctgaat atgatttttc actttcagca 287281 tatggagctt gatcagcagc ccggaaaaga acattgggat ttgaagcccc ttgagctttc 287341 tgatttaaaa tcggttttga caaaatggca aaagaagctt gaacatcaag gctggaatac 287401 attgttttgg tgcaaccacg accagccccg gattgtgtcc agattcggag acgatgggga 287461 ataccgcaaa gcatcagcga aaatgctggc agccgtaatt tattttatga agggcacgcc 287521 gtatatttat cagggagaag aaatcgggat gacaaacgcg ccgttcaccc ggattgaaga 287581 ctacaaagat atccaaacga tcaatatgta tcataaacgg gtgtttgaaa aaggctatga 287641 tccaaatgat gtgatgagat cgatcttagc caaaagccgg gatcacgccc ggaccccgat 287701 gcagtggaac agcggcaaaa atgccggatt tactgacggc acgccttggc tgaaggtcaa 287761 tccgaacttc accgcaatca atgtggagga agcgcaggga gatcctgatt ctgtcttaaa 287821 ctattacaaa aagctgatca gcctgagaaa gcagtacgct gacctcatga aagggagctt 287881 tgatcttttg cttccggacg atccgcagtt gtttgtatac atgagagaaa acagtaaaca 287941 acagcttttg tcggtcaata atttttcaaa agagcaggct gtttttcagt ggcctaagaa 288001 ctgcggcaaa gctcaggcct cactgcttct cagcaattat aacaacgatg atcttgatga 288061 cgaaatggtg ttccggcctt atgagagcag ggtctatctt ctggacaaaa caaactaatg 288121 attgaagtag cccggcattt ttagccgggt ttttttagta catatattcg ctctgcaggc 288181 gggaagaata aatgaaaatg aaatttattc ttgcaaaacg taatgacttc ggtttattat 288241 gatataggat tacaaaatcg ttatcatttt gatttaaagt tactgaaaaa gaggggatat 288301 acgatatgtt taaaaaatgg agcggtttgt ttgtgattgc agcgtgcttt ttattagttg 288361 cagcatgcgg caactcatca acaaaagggt cggcggattc aaagggtgat aaactgcacg 288421 ttgtcacaac gttctacccg atgtatgaat tcacaaaaca aattgtaaaa gacaaaggcg 288481 atgtggatct gttaatccca tcttccgttg aaccgcatga ttgggaaccg acgccgaaag 288541 acattgccaa cattcaggat gctgatttgt tcgtttataa tagtgaatac atggagacat 288601 gggttccgtc agctgaaaaa agcatgggcc aaggccatgc cgttttcgtt aatgcaagca 288661 aaggcattga tttaatggaa ggctctgaag aagaacacga agagcatgat catggggagc 288721 atgagcacag tcatgcaatg gaccctcacg tatggcttag ccctgttctg gcacagaagg 288781 aagttaaaaa tattacggct caaatcgtga agcaggaccc ggataacaaa gaatactatg 288841 agaaaaatag taaagaatat attgcaaaac tgcaggatct tgataaacta tatcgtacaa 288901 ccgcaaaaaa agcggagaaa aaagaattta tcacgcagca tacagctttt ggctatctgg 288961 caaaagaata cggcttgaag caggttccga ttgcagggct ttcacctgac caagaaccga 289021 gcgcagccag cttggcaaag ctgaaaacat atgccaaaga acataatgta aaagttattt 289081 actttgaaga aattgcatcc tcaaaggtcg cagatacgct cgccagtgaa atcggcgcga 289141 agacagaagt gctgaataca ctggaaggct tgagcaaaga agaacaggat aaaggtttag 289201 ggtatatcga cattatgaaa caaaacctcg atgccctgaa agattcacta ttggttaaat 289261 cataagatag tgtgcgccgg aggggtgcac actatttctt tgtgagaaag gaagattaac 289321 atgaatctcg tctcattgaa agatatcgtt ttcggctatt cccatacgcc tgttttagat 289381 aaagtatcac ttgatattga aagcggtgag ttcgtcggca tcactggacc aaacggcgcc 289441 tctaaatcga cgctcataaa ggtaatgctc ggcatgctga aaccgtggga aggcacagtg 289501 acgatcagta aaaggaatac agaagggaaa cgcctgacca tagggtacgt cccgcagcaa 289561 atttcttcat ttaatgccgg atttccgagc acggtgctgg agcttgttca gtcaggccgc 289621 tatacaaaag ggaaatggtt taaacgttta aatgaagaag atcatcttga agtagaaaaa 289681 gcattgaaaa tggtggaaat gtgggacctc cgccatcgta aaatcggtga tttatcaggc 289741 ggacagaaac agaaaatctg tatcgccaga atgctcgcca gcaacccgga tctgctgatg 289801 ctggacgaac cgacgacagc tgttgattac gacagcagaa aaggatttta cgaatttatg 289861 catcatctcg tgaaaaatca caaccgcaca gttgtgatgg ttactcacga acaaaacgaa 289921 gtacagcaat ttttagataa agtgattcga ttagagagag gagaaaaagg cggatggaaa 289981 tgtttgactt ggaattcatg cgacgagctt ttctagcagg cggcatgatc gccgtcatgg 290041 ctccgatact aggagtgtat ctcgttctca gaagacaggc cttaatggct gacacacttt 290101 cacatatctc attgtcaggt gttgccatcg gcttttttct cagcaccaat ataaccgcag 290161 caagcatagt cgtcgtgacc atcggcgcga tcggaattga atacatgcgg cgggcgtatc 290221 ggacttattc agaagtgtcc attgccatct taatggcagc tggtttgtcc ttcgcgatgt 290281 ttttaatcag cctttccaaa ggcacagcca atatgagcat cgatcaatac ctatttggat 290341 cgcttgtgac agtaaaccag cagcaggtct atattatcag tattatcaca ctgctgatcc 290401 tgctttattt tattgtactg agaaggccgc tctacctgct gacgtttgat gaagctacag 290461 ccaaaacatc gggaatcaat acaaacgttc tctcgttgtc attcagtatt gtcacaggcc 290521 ttgcgatttc agtcattatt ccgatcatcg gggtccttct tgtatcggcc ctgctcgtat 290581 tgccggcagc cttcgccatc agaattgcaa aaggctttaa catggttttc attacagcca 290641 tactcatttc attattcagc gtatttacgg gactgacatc atcctatcag ctcgggacgc 290701 cgccaggtcc gtctattacc ctgctattga tcgttttgct attaatcgga tttgcagttc 290761 agggagtttg gacgtttatc aaaaaagaag ctcagcgcaa aaaaagaagc cgataacatg 290821 aaaagcagtt ttccctaggg aaaactgctt tttttataga aacaattcgg caaggcgctc 290881 ataagattct tttttcgcct caaaatcaaa cacattgcac agaaccatga tttcatttgt 290941 ttcgtagcag cctgtgaggt ctaacagctg ttgtttgaca gtggtgggag aaccgatcac 291001 catccgcttt ctgttttctt ctatgagttt tttatcggac gctgtatagg gatgagcttt 291061 cgcttcctcg atgcttggca cgcggctgtc caagcctttt ccgacgcgaa gaagccacag 291121 atcctggctt aatgcgagtt cttctgcctc ttcatctgtt tttgcgcaaa tgacaaaaat 291181 cgtaaacagt gcggatggat tcgaaaaatg ggctgagggc cgaaagcttt cccggtagat 291241 gcggaatgca ttttctcctc gctcgggatt aatgaaatgc ccaaatacat atccaatccc 291301 ctggtgcgcc gcgcgtcttg cgctgttttc accaagaccg agcacccata gctcgggtgc 291361 cgtaccaata aggggcgccg ctttgattcc ggcatacgga tggtcgggag gaagggaatc 291421 tgttagaaaa taagagacat cctgcagctg tctgttaaat tcggttaagc tttttttcac 291481 cccgtccgtt aatgcaagtc tggtttttgt cgtgccgccg ggggagcgac cgacgccgag 291541 gtcaatccgg tttggataca gggcctcaag ctggcgaaag gtttcagcca ctttaaatgg 291601 gctgtattgg ggcagaagca cgccgcctga tccgacacga atggtgtttg tctgtgctgc 291661 gatgcgggcg atcatgattt caggcgctgt gcttgccagt cctttcgtgc tgtgatgctc 291721 ggcaaaccaa taacgcttat agccccactg ttcgcttaat tgggcaagct caaccgaatg 291781 ctggagagtt gtcacagggc tttctccttt agaaacaggt gcctgatcaa gtatgcttaa 291841 atgaatcaaa aggccgcttc ctttctgtct gtttttagat ggtgacacca gaataggcaa 291901 aatgacttgc ccgcgtcaaa tggtttgttt aagaagcgca ctttatagca tttgcaaatc 291961 atatatcaaa tatggaagtt ttttttcgag gtttttcgtc aattattctt aacttttacg 292021 aaactttgat ataataacaa acgtatatat tagtaattta cggcttattt tccttgtgag 292081 cgtaaaaata aatgtgacta tcttcacatt ttgatgagta ggagtgaatc gtgtggcaat 292141 ttctttagaa aaaggtcaac gaattgattt aacaaaagga aaagccggtc tgtcaaaatt 292201 gatggtcggt ctcggctggg acccagtgtc ctcaggcgga ggattcttca gcaaactgct 292261 tggcggaggc ggtccgaata tcgactgtga cgcttcagtg ctgatgctgg aaaacggaaa 292321 attcaccgat aagaaaaacc tgatttattt cggcaacctg aaaagccgct gcggcggtgt 292381 acagcataca ggcgacaacc tgacgggtga cggtgcgggc gatgacgagc aaattatgat 292441 agatttagat aaagtgcctg gaaacatcga taagcttgta tttgtagtga acatttacga 292501 ttgtgtcaga agaaaacaag atttcggcat gattcaaaat gcgtttatcc gcgtagttga 292561 tcaatctaat cacgaggaaa tgctcaagta caatttgaga gacaattacg ccggcagaac 292621 aagcctgatt acagcagaaa tctaccgcag cggcagtgag tggaagtttg cggcggtcgg 292681 tgaaggcaca aacgatacga gattagaaga tattatcagt cgatacgtat aaaagaaaag 292741 gagtggatga aacatgacaa tttcattggc aaaaggacaa aaagtagatt taacaaaaac 292801 aaatccgggt ctttcaaagg ttgttgtcgg tttaggctgg gatacgaaca agtatgacgg 292861 cgggcacgac tttgatcttg actcaagtgt gtttctgtta gacgccgcgg gcaaatgcgc 292921 gtcaccaaac gactttattt tctacaacca gcttgaaggc ggcaacggtt cagtcgttca 292981 ttcaggcgac aacctgactg gtgctggcga aggcgacgat gagaatgtaa aagtaaatct 293041 cagcgctgta ccggcaaaca ttgataaaat ctcatttgtt attaccattc acgatgcaga 293101 agcgcgcagc caaaactttg gacaagtatc aaacgcgttt gtccgcatcg taaatgaaga 293161 aacaaatgaa gagctcatcc gttacgatct tgcagaagat ttctctattg aaacggcaat 293221 cattgcaggg gagctttaca gacataacgg cgagtggaaa ttctcagcaa tcggctcagg 293281 ctaccaaggc ggccttgccc gcattgcaac agactacggt ttgcaagtcg gttaagacaa 293341 atacgaagag cagaaaggag agaggcagta tggccattca attatcaaaa ggacagcgca 293401 ttgatttaac aaaaacaaat ccgggactga ctaaagcggt gatcggctta ggctgggata 293461 caaacaagta ctccggcgga cacgattttg acctggatgc ttcggccttt ttagttgatg 293521 cgcatgataa ctgcgtaaat gatctcgatt tcgtcttcta taataacctt gaacatccga 293581 gcggcggtgt catccatacg ggtgacaacc gcacgggtga gggcgacgga gatgatgagc 293641 agattatcgt tgatttctca aaaatccctg ctcacattga gaaaatcggc atcacagtga 293701 ccattcacga cgctgaagca cgcagccaaa actttggaca agtttccaat gcatttgtcc 293761 gcgttgtgga tgaagaaacg cagaatgagc ttcttcgctt cgatttggga gaagacttct 293821 ccattgaaac agctgttgtc gtttgtgagc tttacagaca cggcggcgag tggaaattca 293881 atgcaatcgg cagcggattt tccggcgggc tggctgcatt gtgccggaat tacggtttgc 293941 aagtgtaagc gagtgacaaa tagagaagtc accgtttcaa attataggag gaaaaaactt 294001 ggacttttta catcatattt tgtctacgta tgcttcattt ttcgattgga aaatgtgggg 294061 ggaagttctg actgatcctg tttcctgggg tttgatcggt tcccttgttg ttctggaagg 294121 ccttttatcg gccgataacg cgcttgttct tgcggtcatg gttaaacacc tgccggaaaa 294181 acagcggaaa aaagcgttaa cgtatggttt gtttggagct tatattttca ggtttatttt 294241 catcgggctc ggtatgcttc tcattaaatt ctggtggatc aaggtgcttg gcgcgcttta 294301 cctggcttgg ctcgtcatta agcacttctg gataggcgaa aaagaagagg aagcggacgg 294361 catgaagaaa aactcttgga tggtccgcac gttcgggatc ttctgggcga ctgtcatttc 294421 agtagaatta atggatcttg ccttctctgt ggacagcatc ctggccgcgt ttgcagtatc 294481 tgaaaaagta tgggtgcttc tgattggcgg tatgcttggt attttaatga tgcgtacagt 294541 ggcaaaagtg ttccttgtgc tgattgataa aattcctgag ctggaaaaca cagcattcgt 294601 cttaatcggc attatcgcgc tgaaaatggc ggggagcgct ttccattacg aaatgccgca 294661 ctctgtattc ttcattatca ttatcgctgc atttgcggta acattgatca ttcactacat 294721 caataaacaa aagcaggtgc gcgaacaaac agccgcttca aaagaagaat aaaacaaaac 294781 aaggagggag gttcaatgtc cttccttttt tgttaccgaa atatcgtttc aatgacaaac 294841 cggaaaggag gatatgatga gacaagaaga actaaccatt cataaagcac ttccggctga 294901 tggcgattgg aaaagcctgc tgtttcagcc attgccggag cgggatcact atgaaactgc 294961 acaaggcctt tctttttctc gtcttgccgg tcagatattg ggcacgccta ttgatgagac 295021 ggactactat aacgagctgt atgagctgtc tgtaaacgac cgcataacga ttttgagtga 295081 aacgcttgat aaaacaatcg aaccggaaac atttcaaaag cttcagcata ttcattccat 295141 caatcagaaa gaaaaagggc tgtcagtcag ccgctttgtt gcctttctgg acggggaaaa 295201 gctgattgcg aagcactcaa atcccttgat gcaccgccat ttaagaaaag cgttgatgac 295261 gcttttacat acctttgcgg acagtcatga aaaggggctg aatcatcctg attttcgcag 295321 agtgctgctt gatgtctcga agttttcctt aaaccatctg aacccttggc tggaaaaaac 295381 cgatatagag cgggagatgc cgaaggttgt ttggtatgga gatgcgacga aaagccagct 295441 ctatttctta tattatctga tgctggtcgg ctgtgatgta ctgctgttcc atccggcggg 295501 aacggatcag ctggcgcttg tcgacccgaa gcaggagctc ggttttacgg aaaagctccc 295561 ggatgtttcg gagcttcagc cgtttccgaa agaaaaacca gaccggaaat caacagtggc 295621 ttaccgctca acaaaggaaa ttgaacatgt gctgaatcac gaggaatcca tgctatataa 295681 gccgtggcag ttcagagatc acacaccggt gtccgttacg ctgaaaacga cctatgatga 295741 attgttttta atcacgaaag aacgcgcctt tattcggccg aatttcaaag ctgataaaca 295801 ttccattgag attccgaatg tattcgccaa aattatgggc gtgtcgaaag acaataagga 295861 atattggaac aggcttcata ctctagcgga ttatcaggaa acagaaatgg tcagaagctt 295921 tccatttaca gaagaaataa agtcgaacta tcaatttcac tacagccacg cacttgatca 295981 agaagggaac attgatccgg acaagctgat ggcaagcaat gtgtggcagt acaaacagct 296041 gccggcgggc gttcagactg ccattgccaa aacgatttcg agaatgtgca ggtacccgcg 296101 gcttaaagcc ttgcatcagg aacaagtcaa ggatgttcaa atctatttgt ttaaacaaac 296161 aacaaacctg cctgctaatc tgctgaaatt gattcaaatg ttcgactatg cgcaaaccgt 296221 tccgaaactc gttttatatc atacggaaat gagcggcgga ctcacgcgtt cggatgctgc 296281 cgccctgctg ttcctgaatg aaatcggaat cgatatcatc atttataatc cgcccggaca 296341 ccaagatatt gagcagttta ttgaagagga tcagtatgat atccactggc tggatgacat 296401 ggtgtttcag caggactaca aagagccttc gcttgtgaaa aggctcttca gaaccattac 296461 ccaaaaataa ggagagaaga aaagcatgac aacagaaaat caaaatccgc ttgttctcga 296521 taaaaatgaa gagatttccc agcaaaaagc tgacgatatc cgtcttcagc tccgtcagga 296581 accagaagtg aagcggcttg ctcaacaaat tgacgtcaaa aaccaaatgg agctgcttga 296641 gtacggcaag gagccggccg ttgaaatatc caagttctct gaccgcatct tggggatgat 296701 gaaaacaaca agcgtgacag actccggcac aatgctgact cagcttggga aaatcatgga 296761 ccgcttcgac aaaaatgatt ttgatgagcc aaagggatta atggcgaaaa ttttcaaacg 296821 cggcggcagc atgattgaaa aaatctttaa aaagtatcag acgcttggcg gagagattga 296881 aaaaatccac gttgagattt caaaatacaa agatgagatg acgaagacga actacacgct 296941 cgatgaaatg tatgaaaaca atatcaaata ctatatggag cttgaaaaat acgtcgttgc 297001 cgggcagatg aaactggaag agatgcagtc gatccttcct tcatatgagg aaaaagcggc 297061 aagcgggaac cagctggcgc aaatgcagct cgatacgttg cgcaacggca ttcaggcgct 297121 tgaggaacgg gtgtatgatc ttgacatggc acggatggtg gcgcttcaaa ccgcacctca 297181 aatccgtctc ctgcagcgag gaaatgcaaa gctgatcggg aaaatcaact ccgcgtttat 297241 cattaccatt ccgattttca aaaacggcat tattcaggct gttacggtaa agcggcaaaa 297301 gcttgtggct gattccatga gcgagcttga ccgccggaca aacgagatgc tgaaacgaaa 297361 tgctgaaaac atctcgagcc aaagtgttga aattgcgaga atggccggca gaccgagcat 297421 agatattgaa acgattgaat cgtcttggaa cacgattgtc agcggcatgc aggaaacaaa 297481 acaaatcgaa gaagaaaaca agcgcctccg cgaagacggc gcgagacgaa ttgcccagct 297541 tcaggataat attaaaaaag cagcattgca gcaataataa aaaccccgct tgtggaacat 297601 aagcggggta tttcaattac atcatttagt taatgacaat gtgtaaagac aggtgtaaac 297661 ttaaacggta atcattttgc atatcagagg tgttggcaat gggaaaacaa cagcctatat 297721 cccagcgtaa actgctgggc gtcgccggtt tggggtggct gtttgatgca atggatgtcg 297781 gaatattatc gtttattatc gccgcgctcc atgtagagtg gaatctgtcg cccgaagaaa 297841 tgaaatggat cggaagcgtc aattccatcg gcatggctgc gggtgcgttt ttgtttggtt 297901 tgcttgctga tcgaatcggc cgcaaaaaag tgttcatcat caccctttta tgcttttcca 297961 tcggaagcgg catttccgct tttgtgacga gcttatcggc atttctaatc cttcgtttcg 298021 tgattggtat gggacttggc ggcgagcttc cagtcgcttc aacactcgtt tcggaagcgg 298081 ttgtgcctga aaagcggggc agagtgattg tgcttttgga aagcttttgg gccgtgggct 298141 ggctcgcagc ggccttgatt tcttactttg tgataccaag cttcggctgg caggctgccc 298201 ttctgttaac tgcgctgact gctttttatg cgctgtacct gcggacgagt ctacctgatt 298261 cgccgaaata tgaatcgctt tctgccaaaa agaggtcgat gtgggagaat gtaaaaagcg 298321 tctgggcaag acagtatata cggccgacgg tgatgctgtc gatcgtttgg ttctgtgtgg 298381 tgttttctta ttacggcatg ttcctatggc tcccgagtgt catgctgctg aaaggcttca 298441 gcatgattca aagctttgaa tatgtcctgc tgatgacgct tgctcagcta cctggctatt 298501 tctctgccgc atggctgatt gaaaaagcgg gccggaagtg gatactcgtc gtttacttga 298561 ttggcacagc aggaagcgcc tatttcttcg gaacggcgga ttccttaagt cttctgctta 298621 cggctggagt gctgttatcg tttttcaatc tcggtgcgtg gggcgtgctg tatgcttata 298681 ccccggagca atacccgact gcgattcgag caacaggttc aggaacgaca gcagcgtttg 298741 gaagaatcgg cggcatcttc gggcctttgc tcgtcggaac cctggcagcc cgtcatattt 298801 cgttttcggt catcttttca atcttttgca ttgcaatctt acttgcggtt gcttgtattt 298861 tgattatggg gaaagaaacg aaacaaactg agctagaata ggaaaagcac ctcttaaaag 298921 aggtgctttc agcgtgtcga caaaccctcg cattcgttgt caggactgcg cttcggtgct 298981 caatgcgaag tggatcaacg gctaaattct caggcgtcct gcctaaacgc cgtcgtcatc 299041 acatcctgtg aatgtccgct cctatgctcg tccttcctag acttcaaggg ttttcaatca 299101 cgctgaaaag attttgtcaa caatctgagg cacctcttga atgaggtgct tttttacaat 299161 tgcgcccggg ctgtggattg gcgtttcccg gttttactga ttgtctggta gagcgtcata 299221 gaaagtatga acagaatggc agtaaatcct gtgacagctc cgaaatgctg tgtgctttga 299281 tataaaaaac ctgcaatact tgtaccgaca gtggttccgg catacatagc ggcattggaa 299341 agggaagcga tggttcctcg cgcatttggt gcaatggatt gaaagacacc catcattaac 299401 ggaaagatga tgccagctgt aaagaacgtg agaaaaaagc cggcttctac taaaaacaag 299461 tttggaaaga acggaagagc gaaatagaga gcgcccatta gcagcatccc gctgatcagt 299521 gttttaaaca tgcccagctt ttctgaaacc cggctgccga taaggctccc gagcatattt 299581 cccagtccga gtacaagcat agctgcgcca atttgtgaca cggttaaatg ataatccgcg 299641 gaaagccaag tacccagaaa gctgaacgat gcgaagtttc cggtttgaaa cagaaaatag 299701 gcaagcagaa tgaccgatgt tttcggcaat gaaaaaagct cccgataggg gttgacaatt 299761 gatgggcgcg ccaatggttc agaaggccgg atgccaggca tgaccgccgc caggatcaat 299821 agaagaataa gcgagcacgc tgacaaaacg aaaaatggcg tatgccatgt aaaggaagcg 299881 agaaaccctc caataggaag tccgagcatt tgtgaagcgg ccaaacctgc tgtcgcaatc 299941 cccatgcctt ttatgatctg agaaggctgg acaatgactg ggatggacgc ccaaatttga 300001 ggcgtcacaa acgcagcgct aacgcctgcg gcaaaacgga acaggcacat ggcggcaaaa 300061 gagggagcga tgccgcataa aaatgtggat acgataaagc ctgcaagtcc ccacagcatg 300121 actgttttcc tgttcagccg gtctgagatt gggcctgcaa tgaaagcgaa gagtgcataa 300181 ccgagtgcat aagcactgac catccagcct gacaaatcag tagagacatg aaactgatcc 300241 tgtaaaaggg ggagaagcgg cgaaagcaaa aaggtatccg tgccaatgac aaacatgaca 300301 ctgaagaaaa gccaaatgcg attcaaattt tatcactcct attgttttat aactttaaaa 300361 ctatgaaaca gatatgtata gagaaaaccc tttgttagag ggtttccaaa aagccaggca 300421 ggtatgtttg aaatgtgtct tcacgcagac tgacgtattt tgtccgcgaa tctttccggg 300481 ttgccgtcaa tcccgcttca cgcagcgttt taaaatgata agatgccgtg gttttgacaa 300541 tattgcactt ttcacctact tcaccgcagc tgagttcttt tccgctgaca taaagcgtac 300601 gaataatggc aagccttgat tcatcagaca gtgctttaaa aatttgcgct ctgatttgat 300661 catctgattg tttcatagtc atgaaactat aatacataat gggtgttgaa aaagcaactt 300721 atttttccag taaaggagca ggaagtcata agaggaagga ggaattcaat tccaataaaa 300781 gcgttttcaa ctaaaggtag gagaaaaatc acccgtaaaa tacaatcata taggaggatt 300841 acagagcatt tagaagcata aataagatca tgtggtcaca tggatgttta taaagaaatg 300901 gtacagaata aaagagaata tgctgtttgt gtgggaagtt acataaatgt tacggtaata 300961 aagattgctt aatatggagg gaaaatatga gtgtagatga gaaaccaatt aagataaaag 301021 tcgagaaagt ctctaagatt tttgggaaac aaacaaagaa ggcagttcaa atgcttgcca 301081 acggaaagac aaaaaaagag atcctgaaag caaccggatc aaccgttggg gttaatcagg 301141 cagattttga agtatatgat ggtgagatat ttgtcatcat gggtctatca gggagcggta 301201 aatcaacttt agtacggatg ttaaaccggc ttattgaacc gactgccgga aatatttaca 301261 ttgatggtga catgataaca aatatgtcaa aagaccagct ccgggaagtc cgccggaaaa 301321 aaatcagcat ggtcttccaa aagttcgctc tgtttccgca cagaacgata cttgaaaaca 301381 cagaatacgg actggagctt caaggtgtag acaaacaaga gcggcagcaa aaagcgcttg 301441 agtctcttaa gctcgttgga ctggaaggat ttgaacacca atatcccgac cagctttccg 301501 gcgggatgca gcagcgtgtc ggccttgccc gcgcgttgac gaatgacccg gacatccttc 301561 tgatggacga agcgttcagt gcgctcgatc cactgattcg taaagatatg caggatgagc 301621 ttcttgatct tcacgataat gtcggaaaaa caattatctt tattacgcat gacttggacg 301681 aagcgttgcg gatcggcgac agaattgtcc taatgaagga cggcaacatc gttcaaatcg 301741 gcacgcctga agaaatcctg atgaatccat ctaacgaata tgttgagaaa ttcgtcgaag 301801 atgttgattt gtctaaagtc ctcacagcag gccacattat gaaacgcgct gaaacagtgc 301861 ggattgataa agggcctcgc gtagcattga cactgatgaa aaaccttgga atttcttcaa 301921 tttatgcagt ggataaacaa aagaaattat taggtgttat ctatgcgtct gatgcgaaaa 301981 aagcggctga gtctgatttg tcacttcaag acatcttgaa tacagaattt acgactgtac 302041 cagagaatac gtatctgact gagatttttg acgttgtgtc cgatgcgaat attccaattg 302101 cggttgtgga tgagaagcaa agaatgaaag gaattgtcgt aagaggcgcg ctgattggcg 302161 cacttgccgg caataacgag tatatcaatg ctgaaggcac taacgaacaa acacaagatc 302221 cttctgcaca ggaggtgaaa taagatggat agactgccta gaataccttt agcagatatt 302281 attgaccgtt ttgttgactg gattacgatg acgtttggcg gattcttcga cggaatcgct 302341 aacggattgg ccgcttttgt aaatggaatt gtcaccggtc ttggatttat tccatctatt 302401 ttgttaacga ttattttcgc cgcacttgcg tggtggatca gtacaagggg aattgcgtta 302461 tttacgttga ttggattcct cctgatcgat tatttaggat attgggaccc aatgctgcaa 302521 acattggcgc ttgttttgac atctgtgatt atttcgattg tggtcggggt tccgatcgga 302581 atttgggcgt ctcagaaaga aacggttcgc cgtattgtaa cgccaattct tgatttaatg 302641 cagacaatgc ctgctttcgt atatctattg ccggcgattt tcttctttaa catcggtgtt 302701 gtgccgggtg ttgttgcatc tgttatcttc gcgatgccgc cgacaatccg catgactgtt 302761 ctcggtatta aacaagtgcc ggcggatttg attgaagcga ctgaggcatt cggttctaca 302821 acagctcagc gtttgtttaa agttcagctc ccgcttgcga caaaaacgat tttggccggg 302881 atcaaccaga gcatcatgct tgcgttatca atggttgtta tcgccgcaat ggtcggtgca 302941 ccgggacttg gttctgaagt atacagtgcc gttacacagc tgaaaaccgg ggtcggagta 303001 gaggccggta tcgccatcgt tatcgttgcc attaccctgg accgtattac tcaaaatatt 303061 aaagtgaaga agaaaagcag ggggaatgcc tgatgcttaa aaaaatcata ggcatcggcg 303121 tttccgccat gctggcgctc tcacttgcgg cttgcggttc agaaaacgat gaaaatgcat 303181 ccgcagcaga acaagtgaat aagaccatca tcgggattga ccccggttca gggattatgt 303241 ccctgactga caaagcgatg aaggattatg acctgaatga ctggacattg atttcagcgt 303301 caagtgctgc gatgaccgct acgcttaaaa agtcatacga ccgtaagaaa ccgattatca 303361 ttacaggatg gacaccgcac tggatgttct ccagatataa gctgaaatat ctcgatgatc 303421 cgaaacaatc ttatggcagc gcagaggaaa tccatacgat cacacgcaaa ggcttcagca 303481 aagagcagcc gaatgccgca aagcttctga gccagtttaa atggacgcag gacgaaatgg 303541 gcgaaatcat gatcaaggtg gaagaaggcg agaaacctgc caaagttgct gctgagtacg 303601 tcaataaaca caaggatcag attgccgaat ggacaaaagg cgttcaaaag gtgaagggag 303661 acaaaatcaa ccttgcctat gtggcgtggg acagtgagat tgcaagtaca aacgtcatag 303721 gcaaagtctt agaagacttg ggctatgagg taacacttac tcaggtagag gctgggccga 303781 tgtggactgc aattgcgacg ggaagtgcgg atgcatccct ttccgcatgg ctgccgaata 303841 cccataaagc atacgccgct aaatataaag gcaaatatga tgatattggc accagtatga 303901 ctggtgtgaa gatggggctt gttgttcctc aatatatgaa aaatgtcaac tcaattgaag 303961 atttgaagaa gtaatcaaaa aagcagcctg tgtcaggctg ctttttttgc gttaagaagc 304021 gttagcggca gcaagtgatt ccgccttctg aaatgttttg agcacggcgt tcgccaaaat 304081 atgaatgccg gtaaacatcg catttctgtc aaaggtcatg tgcggatgat ggagccccgg 304141 ctggagcccg cagcctagtc cgagcatcgt tgttttcaga ttcggcacct tcacggcgta 304201 aaaatggaaa tcctcgccgc cggtggtgac aagcgggtca tcaagccgct cagccccgat 304261 gatttccgta atggcttctg ccatgatcgc ttcagcttct ttattttgtg ttgccgcagg 304321 aaggctgtgt tctttgtgca gctcgatctt tgcgccaaat gcagcggcgg ccgcttcaca 304381 ggctctttct gtttcggcga ttaatgcctc catggcttca ttggtctgtg cgcgcaaatc 304441 aaggctgaac gatgcttttc ctggaatgat gttagagctt tcaccgccgg cttgcagttt 304501 tgtcattttg acggtatgcg ggatttgcgg gtcaatatga atgagtccga gcttgtgtac 304561 aagaaatgcc gcaatttcaa tgctgttttt cccgaggtgc ggacgggcgc catgagcctc 304621 ttccccgatg atcgttccct caatgtgctg gcttgatccg tgcagaatag aaggagcgca 304681 gcggccgttc tgtgtttcct ggatcggacg gacgtgaacg ccatacaaat agtcgatatc 304741 atcaagcacg ccttcttcta tcattttcaa ggcgccgccg cctttttctt ctgccggctg 304801 aaagataaaa cggattgtgc ccttcggaag ctcaggttgt ttttttagca gcattaacgt 304861 gcccaatgcc attgtcatat gtgaatcgtg tccgcaggaa tggttggcgc gaaatgtgcc 304921 gttaacctcc tgccacagcg cgtcaatatc agcgcgtacc gctacaacag gtgagcctga 304981 gccgatttcg ccgacaaccc cggtgcagtc tgaaaacgtg cgcgtccggc accctaaatc 305041 ctcaagcttt tgtttcaaaa atgaagttgt ctcatattcc ttccagctga cttcagggtt 305101 cgcgtgcaga tgctcgaaga tgtccataat ggtttgtttc atttcttctg aaagcttttg 305161 catggtaaga aatacctcct tctatcagaa tgaattttta ccttctttac tttatttata 305221 ttgaaacagg aagataggct gtatataata tagcacatat tgctactatt cagaataatt 305281 aatattttca aacagagggg atggatcgaa atatgagtat gccagcagcc gaaacacagc 305341 ctaagaaaaa acgtatgaca tttaaaatgc ctgacgccta tgtcctctta tttatgattg 305401 ctttcatttg cgcaatcgct tcatatattg tgccggcagg tgaatttgac cgcgtgacaa 305461 agggggatgt cacgaccgct gttccgggaa gctatcattc aattgaacag tctccggtca 305521 gattgatcag cttttttact tctctacagg atggaatggt tggatcagca cccatcatct 305581 ttctgatttt attcacaggc ggcaccattg ctattctaga aaaaacgggt gccatcaatg 305641 gcctgattta caatgtcatc agcaaattcc gcacaaagca attattattt atttgtattg 305701 tcggcgcatt gttctccatt ctcggaacaa ccgggattgt cgtgaattca gttatcggtt 305761 ttatccccat cggcctcatt gtggcacgat ccttaaaatg ggacgcagtc gcgggagccg 305821 ctgttatata catcggctgc tacgctggat ttaactccac catattatca ccgtcaccgc 305881 tcggtttatc acaatcaatc gcggagctcc ctcttttctc aggaatcggc ctgcgagttg 305941 tgatatacat atgctttttg ctgtcttcta ttatttatat ctatttgtat acgagaaaat 306001 taaaaaaatc aaaagatgcc agtgtgttag gaacagattg gttccctgcg gcaggaatgg 306061 gcgaagccgg taaagaagaa gatcagtcag tgccgtttac cgttcgccat aagctgattt 306121 tggctgtggc gggactctca cttgtcggat ttttatacgg cgctttgaag cttggctggt 306181 cagattccca aatggctgcg acatttattt ttatttctgt ccttgccggt ttaataggcg 306241 ggcttgcggc gaacgatatt gccaaaacct tcattacggg ctgccaaagt cttgtatacg 306301 gggcgctgat tgtcgggatg gcacgaagca tttccgttat ccttgaaaat ggaaagcttc 306361 tcgatactgt cgtcaatgct ttggcttcac ttttggatgg attcagcccg attgctgggg 306421 caatcggcat gtatatcgcc agtgcgctgc ttcattttct catctcttca ggttctggcg 306481 aagccgttgt atttattcca atcctggcgc cgctcgctga tttgatggga atcacgagac 306541 aggttgcggt tgaagcggtt atgcttggag aaggggtcgt caactgtgtg aacccgacat 306601 ccggcgttct catggcggtg cttgccgcca gcggtattcc gtatgtcaag tggctgcggt 306661 ttatggtgcc gcttgctctg atttggttct tgatcgggct tgtctttatc gtgatcggag 306721 tcatgatcaa ttgggggccg ttttaacgat tgctgcccgc cggcttgtac ggcgggcttt 306781 tgagttattc attgcagaag cgcaggctgt tattgtaaca tgtaagccat aagccattcg 306841 taaaagtgcg ggaggaaggt catgaataat ctgcgtaata gactttcagg cgtgaatggg 306901 aaaaataaga gagtaaaaga aaaagaacaa aaaatctggt cggagattgg gatgatagcg 306961 ggagcatttg cgctgcttga tgtgatcatc cgcggcatta tgtttgaatt tccgtttaaa 307021 gaatgggctg caagccttgt gtttttgttc atcattatct tatattactg catcagggct 307081 gcggcatccg gaatgctcat gccgagaata gacaccaaag aagaactgca aaaacgggtg 307141 aagcagcagc gaatagaatc aattgcggtc gcctttgcgg tagtggtgct tacgatgtac 307201 gacaggggga ttccccatac attcttcgct tggctgaaaa tgattcttct ttttatcgtc 307261 tgcggcggcg ttctgtttct gcttcggtat gtgattgtga agctggctta cagaagagcg 307321 gtaaaagaag aaataaaaaa gaaatcatct tttttgtttg gaaagcgagg gaagcgttca 307381 cagtttcggg cagctttttt tataggaaca ttgatttgta ttcactctgc caagttgttt 307441 tgatagagtg attgtgataa ttttaaatgt aagcgttaac aaaattctcc agtcttcaca 307501 tcggtttgaa aggaggaagc ggaagaatga agtaagaggg atttttgact ccgaagtaag 307561 tcttcaaaaa atcaaataag gagtgtcaag aatgtttgca aaacgattca aaacctcttt 307621 actgccgtta ttcgctggat ttttattgct gtttcatttg gttctggcag gaccggcggc 307681 tgcgagtgct gaaacggcga acaaatcgaa tgagcttaca gcaccgtcga tcaaaagcgg 307741 aaccattctt catgcatgga attggtcgtt caatacgtta aaacacaata tgaaggatat 307801 tcatgatgca ggatatacag ccattcagac atctccgatt aaccaagtaa aggaagggaa 307861 tcaaggagat aaaagcatgt cgaactggta ctggctgtat cagccgacat cgtatcaaat 307921 tggcaaccgt tacttaggta ctgaacaaga atttaaagaa atgtgtgcag ccgctgaaga 307981 atatggcata aaggtcattg ttgacgcggt catcaatcat accaccagtg attatgccgc 308041 gatttccaat gaggttaaga gtattccaaa ctggacacat ggaaacacac aaattaaaaa 308101 ctggtctgat cgatgggatg tcacgcagaa ttcattgctc gggctgtatg actggaatac 308161 acaaaataca caagtacagt cctatctgaa acggttctta gacagggcat tgaatgacgg 308221 ggcagacggt tttcgatttg atgccgccaa acatatagag cttccagatg atggcagtta 308281 cggcagtcaa ttttggccga atatcacaaa tacatctgca gagttccaat acggagaaat 308341 cctgcaggat agtgcctcca gagatgctgc atatgcgaat tatatggatg tgacagcgtc 308401 taactatggg cattccataa ggtccgcttt aaagaatcgt aatctgggcg tgtcgaatat 308461 ctcccactat gcatctgatg tgtctgcgga caagctagtg acatgggtag agtcgcatga 308521 tacgtatgcc aatgatgatg aagagtcgac atggatgagc gatgatgata tccgtttagg 308581 ctgggcggtg atagcttctc gttcaggcag tacgcctctt ttcttttcca gacctgaggg 308641 aggcggaaat ggtgtgaggt tcccggggaa aagccaaata ggcgatcgcg ggagtgcttt 308701 atttgaagat caggctatca ctgcggtcaa tagatttcac aatgtgatgg ctggacagcc 308761 tgaggaactc tcgaacccga atggaaacaa ccagatattt atgaatcagc gcggctcaca 308821 tggcgttgtg ctggcaaatg caggttcatc ctctgtctct atcaatacgg caacaaaatt 308881 gcctgatggc aggtatgaca ataaagctgg agcgggttca tttcaagtga acgatggtaa 308941 actgacaggc acgatcaatg ccaggtctgt agctgtgctt tatcctgatg atattgcaaa 309001 agcgcctcat gttttccttg agaattacaa aacaggtgta acacattctt tcaatgatca 309061 actgacgatt accttgcgtg cagatgcgaa tacaacaaaa gccgtttatc aaatcaataa 309121 tggaccagag acggcgttta aggatggaga tcaattcaca atcggaaaag gagatccatt 309181 tggcaaaaca tacaccatca tgttaaaagg aacgaacagt gatggtgtaa cgaggaccga 309241 gaaatacagt tttgttaaaa gagatccagc gtcggccaaa accatcggct atcaaaatcc 309301 gaatcattgg agccaggtaa atgcttatat ctataaacat gatgggagcc gagtaattga 309361 attgaccgga tcttggcctg gaaaaccaat gactaaaaat gcagacggaa tttacacgct 309421 gacgctgcct gcggacacgg atacaaccaa cgcaaaagtg atttttaata atggcagcgc 309481 ccaagtgccc ggtcagaatc agcctggctt tgattacgtg ctaaatggtt tatataatga 309541 ctcgggctta agcggttctc ttccccattg agggcaaggc tagacgggac ttaccgaaag 309601 aaaccatcaa tgatggtttc ttttttgttc ataaatcaga caaaactttt ctcttgcaaa 309661 agtttgtgaa gtgttgcaca atataaatgt gaaatacttc acaaacaaaa agacatcaaa 309721 gagaaacata ccctggaagg atgattaatg atgaacaaac atgtaaataa agtagcttta 309781 atcggagcgg gttttgttgg aagcagttat gcatttgcgt taattaacca aggaatcaca 309841 gatgagcttg tggtcattga tgtaaataaa gaaaaagcaa tgggcgatgt gatggattta 309901 aaccacggaa aggcgtttgc gccacaaccg gtcaaaacat cttacggaac atatgaagac 309961 tgcaaggatg ctgatattgt ctgcatttgc gccggagcaa accaaaaacc tggtgagaca 310021 cgccttgaat tagtagaaaa gaacttgaag attttcaaag gcatcgttag tgaagtcatg 310081 gcgagcggat ttgacggcat tttcttagtc gcgacaaatc cggttgatat cctgacttac 310141 gcaacatgga aattcagcgg cctgccaaaa gagcgggtga ttggaagcgg cacaacactt 310201 gattctgcga gattccgttt catgctgagc gaatactttg gcgcagcgcc tcaaaacgta 310261 cacgcgcata ttatcggaga gcacggcgac acagagcttc ctgtttggag ccacgcgaat 310321 gtcggcggtg tgccggtcag tgaactcgtt gagaaaaacg atgcgtacaa acaagaggag 310381 ctggaccaaa ttgtagatga tgtgaaaaac gcagcttacc atatcattga gaaaaaaggc 310441 gcgacttatt atggggttgc gatgagtctt gctcgcatta caaaagccat tcttcataat 310501 gaaaacagca tattaactgt cagcacatat ttggacgggc aatacggtgc agatgacgtg 310561 tacatcggtg tgccggctgt cgtgaatcgc ggagggatcg caggtatcac tgagctgaac 310621 ttaaatgaga aagaaaaaga acagttcctt cacagcgccg gcgtccttaa aaacatttta 310681 aaacctcatt ttgcagaaca aaaagtcaac taaccgcaac tttagagtaa agggctgatt 310741 gtcaatgtgg gagcagttgt atgatccgtt tggaaacgag tatgtgagcg cacttgtggc 310801 gctcactccg attctctttt ttcttttggc tttaactgtt ttgaaaatga aaggcattct 310861 tgcggcattt cttaccctag ccgtcagttt cttcgtctcc gtttgggcat ttcatatgcc 310921 ggttgaaaaa gcgatttctt ctgttttgtt aggaatcggg agcgggctgt ggcccattgg 310981 ctacatcgtc ctgatggcgg tgtggctgta taaaatcgcc gtgaaaaccg ggaaatttac 311041 cattattcgg tccagcattg ccggcatttc gcctgaccaa cgattacagc tattattaat 311101 tggtttttgt tttaacgcgt ttttagaagg cgcggccggt tttggtgttc cgattgcgat 311161 tagtgcggcg ctgctcgtcg aacttggttt taaaccgtta aaagcggcgg cgctctgctt 311221 gattgcaaac gctgcctccg gagcctttgg ggcgattggg attcctgtca tcacaggggc 311281 gcagattggt gatttgtctg ctcttgagct gtctcggaca ttaatgtgga cactgccgat 311341 gatctcattt ttaataccat tcctgcttgt attcttatta gaccgaatga aaggaatcaa 311401 acagacatgg cccgctcttc tggttgtgag cggtgggtat acagcggttc agacactgac 311461 aatggcggtg ctcgggccgg aattagcaaa cattttggcg gccttattca gcatgggcgg 311521 gcttgccctc ttcctccgca aatggcagcc gaaagagatt taccgcgagg aaggggccgg 311581 cgatgctggt gagaaaaagg cataccgtgc cgctgacatt gcgaaagcgt ggtctccttt 311641 ctacatttta actgcggcga tcaccatctg gagccttcct gccttcaaag cgcttttcca 311701 agaaggcggg ctgttatatc aatcaacgct cctgttcaaa atgccttttc tgcatcagca 311761 aattatgaaa atgccgccga ttgcgccatc tgccatgccg ttagatgcag tctttaaagt 311821 tgatctgctg tcagcgactg gtacagcgat tttagcggcg gtcatcgtga cagggctgtt 311881 cagcaaaaag ttctcctctc gggatgcctt tgcttccttg aaggagacgg gaaaagagct 311941 gtgggtgccg attatgacga tctgcttcgt gatggggttt gccaatctgg ccaacttcgc 312001 agggctcagc tcttcaattg ggttagcatt ggcgaaaaca ggagacctgt tcccgtttgt 312061 cagtcctgtt ctcggctgga ttggcgtgtt catcaccggt tctgttgtca gcaataatgc 312121 tttgttcggc catttgcagg ttgtcacggg agcgcagatc ggtgcgggtt cagatttgct 312181 gttagccgca aatacggcgg gcggtgtcat ggcgaaactt gtttctcctc aatctatcgc 312241 catcgctgcc gcagcggtcg gccaaacagg caaggaatct aaactgttta aaaggacagt 312301 ggcgtacagc ctgattctgt tattgatcat ttgtatatgg acgtttattc ttgcaagatt 312361 aggagtgtaa tagaaaaaag cagtacatgc ccagcatgta ctgctttttt tatgttaatt 312421 tgctttcttt gtcatttcgg ctgttgtttt cactctggct tttcccataa ataaaatggt 312481 aaccgccgcg aggacaattg gaatcaaagc gagcaaaaag acatacgtga tacttgatga 312541 catcgcgtca ataatgcgat tcaggatcgc atcaggaatc tgggaacgtg ttcccgcttg 312601 gaatatctcc tgcgggtcgc caatattttg cgcagcgcct gatcccgctg agcctttcat 312661 accgctgaag gcgtcattca gcttgtttgt gaatacgttt gtttgcaccg ttccgaaaat 312721 ggtgacacct aaggtcatgc caaatgatcg caaaaatgaa tttgtagagt ttgccgttcc 312781 ccgaaagcga ggttcaagat cattcatcga tgccgccggc agcagggaga agttaaagcc 312841 tacaccaaag cctgaaatca tcataaagac tgtcagccat acccgtgctg tgtcaggcgt 312901 catattggaa agaagcagca tgccgataaa gaaagctata acagatatca gcatcaaatt 312961 gcggaagctt gccttcgttt ggaagatccc gccgatcatg cttccgatga ctgatccaat 313021 catcatcggc gtcagaatga agcccgcgct tgtcgccgag ctgccgtaga ccgcctgaac 313081 gaaaatcgga ataaataccg ctaaaataat aaatgttccg ccatacagga aagcgagaat 313141 ctgtgctgtg gcaaacaagc ggttcttaaa catccagaaa gaaataatcg gctcttctgc 313201 ttttctctcc acaataaaaa aggcaatgaa gaaaacggcg aatacaataa acagcccgat 313261 gatctgaatg gagttccaat cgtatgtttt gccgccaagc tcaagggcga acatcaggca 313321 tacaatggat acgactaagg taatcgcgcc gccccagtct attttctgct ttctgtgctc 313381 cagagattct ttgtagtagc gaataatgaa aaacaatgac aatgcgccga tcggcacatt 313441 gatgtaaaac acccagtgcc agctgatcga atctgtaatg atcgcgccta agagcggacc 313501 aagaacactg gataatccaa atacagcacc gaacatgccg gacatttttc cgcgtttttc 313561 cggcggaaac aaatcaaaga taatggtaaa ggcaatcggc aggagcgcgc cgcctccgat 313621 cccttgaatg gcccggaaga tgatcagctg attcatcgtc tgggcaatcc cgcataaagc 313681 agaaccgatt aagaaaaaaa taagtccaaa caggaaaaaa cgttttcggc cgtacatatc 313741 ggaaagcttg ccgtaaatcg gcatgccagc cataaccgcc accatatagg atgccgtcac 313801 ccaggcaaat ttatcgaagc ttccaagatc ggctacgata ttgcccatcg cggtggcaac 313861 aatcgtattg tccattgcag acatcaagat gcccagcagg agaccgagga ccacaaattt 313921 ggtggaagcc tgttttgctg ttgttgtgtc catttgttct acctcctctt acttttctat 313981 gtaagttctg atatcatgat aatagtttga ttgttgaata tctcgattat caagataaac 314041 tcgattttat agggaggact gtcagttgtc aacaagaaat tccagaagtg agttggaaaa 314101 gactgctgtt cagctttttc gaaaactggg cacaagaacg gttctgtttc atcaggcagc 314161 cgctcaagct ctcggtctgt ttcccaccga tttgaaatca gctgacattt taaatgaagc 314221 agggccgatg acggccggag agctggggaa aaaaaccggc ctcagcacgg gttccgtcac 314281 ggcgcttgtt gaccggctgg aaaaagcggg gtatgtggct cgtgaaaagg acccgaacga 314341 tcgcaggaga gtcgtaatcg tccctttgac tgcttcgaaa aaacatataa aggatttgtt 314401 ccgtcctctg tctgagtcaa cgatggattt gtgccgcgaa tatacggaag aggagctgga 314461 actcattttc agttttgtag gcaaagctgc cgatattatg gaggaagagc ttgaacgtct 314521 gaaacagtaa gtgaatttgt gcatagcttg gcccgttccc gaataaattg tacaagttac 314581 ataagagaag ggagtacggg ccggtgaaca tttttttgag ctatattgtg ctgggactgt 314641 ccttgtctgc gcctgtgggg ccagtgaatg cggcgcaaat agacaaagga attaaaaacg 314701 gtttttggca tgcatggatt ttcggtttag gcgccatgac agcggatggg ctgtacatgc 314761 tttttatcta tttcgggctg tcgcagttct tgaccgctcc atttgtgaaa acgtttttgt 314821 ggctgttcgg cttttttgtc ctgacctata ccggaattga aacgctgaaa aacgtcagag 314881 aaccgatgga tgtgcgaagc tcgcggggga aaccgtcata caggaaaaca ttcgcatcgg 314941 gttttctcat ttcattgtca aacccattga gcatcctttt ttggcttgga atttacggaa 315001 gcattcttgc gaaaacagca gaggcctaca atatgaatca gcttctaatc tatagctccg 315061 gcatcatgat cggcatttta atctgggatt tctgcatggc tatcacagcc agtacgttca 315121 gaaacctgct tcatgaaaag ctattgagag gattgaccgg aatcgccggt gtatccctcc 315181 ttgtgtttgg cttttacttt ggttatcagg gcatcaaaca gttattgggc tgattcatga 315241 aggacagtca cctgccgctt ccagttttaa tatagtatcc agatgatact ggaggtggat 315301 caatggtgaa tgggatttac accaaaagtt ttctggaacg tattcaggaa gagcttcctg 315361 aatggcaaag aatcgctttt gagctgctgg cagaaactct gggggacgac gcggatacat 315421 ttccgtgcat tcccggacgc caggcgtttc tgactgatca gcttcggatt gcttttgccg 315481 gagatccgcg ggaaaaccgc acagcggagg aactggctcc gttgcttgcg gagtacggca 315541 agatatcgcg ggacacggga aaatacgcat ccctcgttgt gttgtttgat acaccggaag 315601 atttggcgga gcattattcg attgaagcgt atgaagagct gttttggcgc tttttaaata 315661 gactgagtca tcaagacgaa aaagaatggc cggaagacat tccggccgat cctgagcatt 315721 ataaatggga gttttgtttt gacggcgagc cgtatttcat tctgtgcgct acaccggggc 315781 acgaggcaag aagaagccgg agctttcctt tttttatggt cacgtttcag ccaaggtggg 315841 tgtttgatga cctaaatgga tcaactgcat ttggccgtaa catgagcagg ctgatccgat 315901 ctcgtttaga ggcctatgat caggctccga ttcacccgca attaggctgg tacggaggaa 315961 aagataatcg tgaatggaag cagtatttcc tccgtgatga cgaaaaacag gtatcgaagt 316021 gcccgttttc ttatttaaag aacatgttca acaaaatgaa ataaatcaag gactggcagg 316081 gcgatcttta tgaccctgct ttttttgata gatcatggta acgatggcga taatcacgag 316141 aaaacctatg ctgacgaaaa aaccgggccg gcttgatttt tcaaacaatg taccggacac 316201 agctgcagca atcagaacca tcgctaaata aatttgcgtt tttcccatgc cctcgggatc 316261 agtcagcttt ttgctggaga acaggataaa cagccaagtg tataaaagca taagccccgc 316321 agctgttgtc atatgctcat aaatgttttt aggcagcact aacgacaaaa taatggagag 316381 gacaagcccc gcaaacgtca gcccaagtgc cggccagcat atttttttgc cttcctttag 316441 agtaaagcat ttcggcgcgt cgccgtcatc agccattgta caaagcaatg tcgtaaccgc 316501 aaatagcgaa gcgacaaggg tcgagaaccc tgcgatgatg aaaatcccgt taaatatatc 316561 aaggatgatc tcaaggttat atccttttaa tgacgtaatg aacggactgt cctgttcagt 316621 aaacgtgtgt aacggaacca aaagcagagc aagcccgatt gaaatgatat aaataatcgc 316681 cagcgtcgcc agcatcagtt tccctgattt agacgcttcc tcaggttttt ttaagtgaac 316741 cgccatcagc cccatgacct caattccgcc aaaagcgtaa aacgcgtaga ttaaacctgt 316801 ccacagcccc atggcgccgt atgggaaaaa ctcactcgtc ttatttggaa catgtatgcc 316861 atgatttccg ccggacagga taccgcataa agccaggatg gcaatgacaa taaacataaa 316921 aatagcagct gttttaatga ctgccagcac gttttctgtt ttttcaaaga cggacaggcc 316981 ggtgaaaata ataaggagcc caagtactgc gtagattgag gcaaacaccc atagcggcac 317041 ttgaggaaac caatgcttcg taaagagcga aatggctgtc agctggcttc cggtaatcag 317101 catttctgat gtccagtaca cccagccgtt gctgaagcct gcccatttgc cgaatgcttt 317161 tcgggcatac gcacaaaacg agcccttttc cggctgcttc gccgatagct tggcgagctg 317221 ttcaaagaca aaatacgtac cgatccctgc gatcagaaat gaaaggagaa cggaaaaacc 317281 gctttttaca attgcgatgc tggaaccgag aaagaagcct gttccaatcg tgcagccgac 317341 tccgatcagt gacagctgcc accaagccag attccctttt ggctggtctt tttttgtttg 317401 gctcattatt tattcaaccc cttttatcta aggttagatt gtgatctgtc caaagcttat 317461 atacatcgga tttttgcctc tttttacatg gagaaggaag cagacgctca tactaatgaa 317521 aaaaggagca aaccaatgac acagcaatat attgtggagc cgaaaaaagg gcttgggctg 317581 aagctgaaaa aggggcagat tttaaaggtg gttgatgtag aagggcagca ggtggctgat 317641 tttgtcgcat accatgccaa ggatttttat gaacaccttg atcagggagc gacgatagac 317701 gccaatcact ccattcatgt gaaggtcaac gaccatctct actccaacct gtataagccg 317761 atgttaaccc tgattgaaga tacggtcggc aagcatgatc tgctgttgcc cgcctgccgt 317821 cctgatatga acaggctctt atatgggaag caaaaggatg agtttcagga tacgtgctat 317881 gacaatatga accgtgcgct tgagcagttt ggcgtaccga agccccacat gcattaccca 317941 tttgcgattt ttatgaatac tgtccttgat gagaaaggga atctgtctgt ggaaacgccg 318001 ctttcgaatg ccggagatta tgtaaggctc agggcggaga tggatttaat tgtcgcgttt 318061 tcttcctgcc cgattgaaaa agggaaatgc aatggcgaca gtgtgacatc catacgggtt 318121 gaagtcagct gatctctctt gttcacagtg aatgaagacc tgtgctatat ttaataggga 318181 tacataacag tcatgattca ttttcattga tttagggaaa tgatcagtaa taagggaaaa 318241 tgtacaggag gaatgattgg gatgagcatg caggaaaaga ttatgcgtga gttacatgtg 318301 aagccctcaa ttgatccaaa gcaagaaatt gaggaccgag tcaatttttt aaaacaatat 318361 gtaaagaaaa ccggtgctaa aggctttgta ttgggaatca gcgggggcca ggattcaaca 318421 cttgcgggaa gactcgctca gcttgcggtg gagagcattc gcgaggaggg cggagacgct 318481 caatttatcg cggtccgtct tccgcatggc acacagcagg atgaagacga tgcccagctt 318541 gctttgaagt ttattaagcc ggataaatca tggaagtttg atattaaatc gacagtcagc 318601 gctttttctg atcagtatca gcaggaaaca ggcgatcagc tgacggactt taataaagga 318661 aacgtaaaag caagaacaag aatgatcgcg caatacgcga tcggcggcca ggaaggtctt 318721 cttgtgttag gaacagacca tgctgctgaa gcagtgactg gtttctttac gaagtacggt 318781 gacggcggag cagacctcct gccgctgaca ggcttgacga agcgccaggg aagaaccttg 318841 ctgaaagagc tgggtgcacc ggaacgctta tacttaaaag aaccgactgc cgatctgctc 318901 gacgaaaaac cgcagcagtc ggatgaaaca gagcttggca tttcctacga cgagattgac 318961 gattatctcg aaggaaaaga agtatcagcg aaagtatcag aagcgctgga aaaacgctac 319021 agcatgactg aacataaacg ccaggttccg gcgtctatgt ttgatgactg gtggaaataa 319081 gttgaagaaa gcccgctctc ggagcgggct tttgtcgtgt acagaagctt tatttgatgc 319141 ggatatgatt cagctttacc attaatctgt cggcgaacct tcggaggctg cctcttgtat 319201 caggatctaa tgggagttcg gctctcgcgg caatgttctc tgccacatcc tgaatcgaca 319261 ggttgtctgt ttgaatgtgg tcctcaaaaa tgggtgatga taatccttca acacagcggt 319321 caatttgttt ggcggcccat gagttttttc cttctgctct ggtgcgcagc ctttttaaca 319381 aggtttcctt tgaagccatt agtgtaaagt ggtgaacgat cctgccttcc tgtctgagcc 319441 tgccgatgat ctcattgaag tattcagggt gtacaatcgt cataggcaca ataaggatgc 319501 cgcggtatgt atctgtcaga gaagctagca aactgtaatt gaacgcccgc cataaaggat 319561 agctttgaaa atcgtccttt gcgatctcct gcggcaccat ggagcgcagc gcaaaaccca 319621 ttttctcggg atcatacacg taagatgggt tcagccttct gtgcagttcg aaggctgttt 319681 gtgtttttcc cgaaccgaat gccccgttta tccaaatgat catcgccatt tctcccttcc 319741 tatttatcat acagaaaaag acccttccat cgaagagtca gctggaaaaa caataaaggc 319801 ggaaggtttt aacgcttttt tgcgtcgaag tattaaaata cctgcagaaa tgttgtacaa 319861 tgaatgtcat tcaggcaaaa atggctacaa caaagcgcac tataagcttg accggtaaag 319921 ccggtatcta tataaatatt cgctaaataa gcatataatg aatatataat ttcattcctt 319981 aggaggattt cgccgaagat gaacgctaaa cgagccatcc cagtaagaga aagaaatatc 320041 gtcctgatcg gattcatggg tgtaggaaaa acaacaatcg gccaattggt cgctaaaaaa 320101 ttatatagag attttattga tattgaccag cagatcgaaa aggatttcaa tatgtcaatt 320161 cctgagatat ttgagaaaaa gggagaagac tttttccgga aaacggagaa ggaatatatt 320221 ttagacatct gccatcataa acgattcaaa atcgtatctc tgggcggggg atcttttaaa 320281 caagaagaaa tcagaaattg ctgtctggaa aactgtctcg tgcttcatct ggacctgtca 320341 tgggagaact ggaagcagcg cgcggattta ttgatcgaaa gccgccctgt actgcataac 320401 cgttcaatgg atgaaatgga acagctgttt aacgaaagaa aagtcattta tgacaagcac 320461 aattcaaaag tggcaacaga caacctttcc ccggaagagg ttgccgatta cattgttgag 320521 acattaaaaa ttggctggga tctttatcag ccgatgtaaa aagccgtgcg cagcgcacgg 320581 ctttttttat cgttttatcc cttgtatcaa aatcgctttt aaacaaaagg agatgggctg 320641 tccgttttgg ttcaatgtaa tacagaacgt gtcgcgtgct tcgtctgatg cgtgattcaa 320701 gtgggtaatg atttgttttt ctcggtcagc gggggttccg cctcgtttga tccagctatc 320761 gtattgaatc ggcaagttcc acttttggat gtcttgatag gccagttgat tggcgctgaa 320821 catcgcctgc cattctgata atgagctttc acgaacatgg gaagggtctc gaagccggtt 320881 caaatgattg acaaactcat caagaacggg atcttcaggc gcgtaatgat caactaagag 320941 aaaacgtccg tcctgtttta gtacgcgtgc aacctctctg acagctttgc ggacatctga 321001 aaaatggtgg gctgcgtatc ggcaggtgat gatgtcaaat gaatcgtcgg ggaaggggag 321061 tgactctgcc gttccttgct gaaagcgtac gttttcaact cctttttctt gcgcgaagga 321121 ggacgcaacc tcaaccatct ctttcgttgc atcaacaccg atgcactcct gtacataagg 321181 agaaaatgcc agcgccgtat ggccggcgcc cgctcctata tccagcactc gatgctctgc 321241 ccggcattcc gctgttttga tcatcaaccc caaatcttcc ccctcggcaa ataccttttc 321301 atcccgatac atctcggcgt ttttagaaaa cggtgtttca tttgtcattt gaaccagctc 321361 cttcttttcg taaatgatga tatggattat gttagcaatt tctgttatga ttcgtccaag 321421 atataaaaat gatgaaaatg ataggttcaa cctatggagg ctgaaatgga tattaaagtg 321481 atggaatatg cagcggaaat tgcccggcgc caaagcttta caaaggcggc ggaacatctt 321541 catatcgcac agccgtctct cagccagcaa atcaaaaagc ttgaggctga gctggggctt 321601 accctttttc acagatccca tggctctgtt acactgacac ctcacggcag gcgtttcatt 321661 gaaaaagccg aggacatcat tcgttccaga gatgatttgc ttcgggaaat gcaggagcga 321721 tcacagggaa tcggtcataa attatccatc gggattcctg ctgtaacagg gagatatctc 321781 tttcctccgc tgctgaagca gtttttggcg cgctatcctc atgtggaggt tcagcttgtt 321841 gaaaaagatc cggtttcatt agagaagatg acggcaaagg gagaagttga cctttctgtt 321901 ttatccttgc ccatcgagga tgaacggctc tccattacac ccttgctcac ggaaccggtt 321961 gttctcgcgg tgccgaagga aaaacaaagg tggatgccgc cggaattggt cgcgctgatt 322021 gagaaagcgc tggaagaaga tgagggacgc cagccgtgtg tgccgattga catggtaagg 322081 aacgtgccct ttattctgtt aaaagaaggc ttcggctttc gcaggacagt tctcgatctc 322141 tgtgcggaaa gcggctttaa gccgaatgct gcctttaaga cgagccatat tgaaaccgcc 322201 caatctcttg tggctaacgg attaggtgtg acaatggcac cgaatatggt cagaagggat 322261 aaagatccgg gtgtgatcta tttatcgatt caatccgcgc catcacgaac cctcgtcttt 322321 gtctttttaa agaaccgcta tgtcagtctg acggcccagg cctttatgga actaagccgg 322381 gaaagtctta aacaaacgtt tgatgaaggc tgtctgggaa acaaagatga aaatatttag 322441 aaaacaaaga cgaaacgtgg tagtatagga atacaaacta aatcttataa aacaaagggg 322501 aataatcgga aatgcaacta ttcgatctgc cgctcgacca attgcaaaca tataagcctg 322561 aaaaaacagc accgaaagat ttttctgagt tttggaaatt gtctttggag gaacttgcaa 322621 aagtccaagc agaacctgat ttacagccgg ttgactatcc tgctgacgga gtaaaagtgt 322681 accgtctcac atataaaagc ttcggaaacg cccgcattac cggatggtac gcggtgcctg 322741 acaaggaagg cccgcatccg gcgatcgtga aatatcatgg ctacaatgca agctatgatg 322801 gtgagattca tgaaatggta aactgggcac tccatggcta cgccacattc ggcatgcttg 322861 tccgcggcca gcagagcagc gaggatacga gtatttcacc gcacggtcac gctttgggct 322921 ggatgacgaa aggaattctt gataaagata catactatta ccgcggtgtt tatttggacg 322981 ccgtccgcgc gcttgaggtc atcagcagct tcgacgaggt tgacgaaaca aggatcggtg 323041 tgacaggagg aagccaaggc ggaggtttaa ccattgccgc agcagcgctg tcagacattc 323101 caaaagccgc ggttgccgat tatccttatt taagcaactt cgaacgggcc attgatgtgg 323161 cgcttgaaca gccgtacctt gaaatcaatt ccttcttcag aagaaatggc agcccggaaa 323221 cagaagtgca ggcgatgaag acactttcat atttcgatat tatgaatctc gctgaccgag 323281 tgaaggtgcc tgtcctgatg tcaatcggcc tgattgacaa ggtcacgccg ccgtccaccg 323341 tgtttgccgc ctacaatcat ttggaaacaa agaaagagct gaaggtgtac cgctacttcg 323401 gacatgagta tatccctgct tttcaaactg aaaaacttgc tttctttaag cagcatctta 323461 aaggctgata aatgtgaaaa gccgccgcat atcatcaggc ggtttttttc tgcaaactgc 323521 cggaatgaga acagactgga gacgaataga tatgaaacaa agaatcattg atgaattaaa 323581 acggatcgag cagtcatacg gagtcaaaat cgtgtatgcc gtcgagtcag gaagccgcgc 323641 atggggattt ccctcgcagg atagtgatta cgacgtccgc tttatttatg ttccgaaaaa 323701 ggagtggtac ttttcaattg agcaggagcg tgatgtcatt gaggaaccga ttcacgattt 323761 gctggatatc agcggctggg agctgagaaa aacgcttcgg cttttcaaaa agtcaaaccc 323821 tccgctactc gaatggctgt cctcagacat tgtgtattat gaagcattta cgaccgcaga 323881 gcagttaaga aaactccgca cggaggcatt taagcctgaa gcaagcgtgt atcactatat 323941 caatatggcg agaaggaacg tcaaggatta tctacaagga caagaggtca aaattaaaaa 324001 gtacttctac gttcttcggc ctattttggc ctgccaatgg attgaaaagc acggaaccat 324061 accgccaatg gactttactg ttttgatgaa tgaacttgtt gctgaacccg agctgaaggc 324121 tgaaatggaa accttgcttg aacggaaaag aagaggggaa gagcttgacc tcgaagcaag 324181 aatcgatgtt attcaccaat tcattgaaac ggaaatcgaa agaatcatgg aagcggcaaa 324241 agaactgaag gcagagaaaa aagatatgac atctgaattg aaccgtttgc ttttgaatac 324301 ggttgaagaa gtgtggaagg atggaggaag ctgatgtttt ttgtcgcttc cttttctcct 324361 ttattcgaca gaatcccccc ccgactttct aactatctga ttgtggcaaa cccacaaaaa 324421 taatcagaat ctttgtattt tgagaatatt gtgaacgctg gttttgtcca tttacaataa 324481 actcatacaa atacttctta gattgcgggg tgttgaggtt ggaagtgatc acaagagatt 324541 ttttcttatt tttatccaaa agcggctttc tcaataaaat ggcgaggaac tggggaagtc 324601 gggtagcagc gggtaaaatt atcggcggga atgactttaa cagttcaatc ccgaccattc 324661 gacagcttaa cagccaaggc ttgtcagtta ctgtcgatca tttaggcgag tttgtgaaca 324721 gcgccgaggt cgcacgggag cgtacggaag agtgcattca aaccattgcg accatcgcgg 324781 atcaggagct gaactcacac gtttctttaa aaatgacgtc tttaggtttg gatatagata 324841 tggatttggt gtatgaaaat atgacaaaaa tccttcagac ggccgagaaa cataaaatca 324901 tggtcaccat tgacatggag gacgaagtca gatgccagaa aacgcttgat attttcaaag 324961 atttcagaaa gaaatacgag catgtgagca cagtgctgca agcctatctg taccggacgg 325021 aaaaagacat tgacgatttg gattctttaa acccgttcct tcgccttgta aaaggagctt 325081 ataaagaatc agaaaaagta gctttcccgg agaaaagcga tgtcgatgaa aattacaaaa 325141 aaatcatccg aaagcagctc ttaaacggtc actatacagc gattgccaca catgacgaca 325201 aaatgatcga ctttacaaag cagcttgcca aggaacatgg cattgccaat gacaagtttg 325261 aatttcagat gctgtacggc atgcggtcgc aaacccagct cagcctcgta aaagaaggtt 325321 ataacatgag agtctacctg ccatacggcg aggattggta cggctacttt atgagacgcc 325381 ttgcagaacg tccgtcaaac attgcatttg ctttcaaagg aatgacaaag aagtaaaaaa 325441 ggagagatta tcatgacaac accttacaaa cacgagccat tcacaaattt ccaagatcaa 325501 aacaacgtgg aagcgtttaa aaaagcgctt gcgacagtaa gcgaatattt aggaaaagac 325561 tatccgcttg tcattaacgg cgagagagtg gaaacggaag cgaaaatcgt ttcaatcaac 325621 ccagctgata aagaagaagt cgtcggccga gtgtcaaaag cgtctcaaga gcacgctgag 325681 caagcgattc aagcggctgc aaaagcattt gaagagtgga gatacacgtc tcctgaagag 325741 agagcggctg tcctgttccg cgctgctgcc aaagtccgca gaagaaaaca tgaattctca 325801 gctttgcttg tgaaagaagc aggaaagcct tggaacgagg cggatgccga tacggctgaa 325861 gcgattgact tcatggagta ttatgcacgc caaatgatcg aactggcaaa aggcaaaccg 325921 gtcaacagcc gtgaaggcga gaaaaaccaa tatgtataca cgccgactgg agtgacagtc 325981 gttatcccgc cttggaactt cttgtttgcg atcatggcag gcacaacagt ggcgccgatc 326041 gttactggaa acacagtggt tctgaaacct gcgagtgcta cacctgttat tgcagcaaaa 326101 tttgttgagg tgcttgaaga gtccggattg ccaaaaggcg tagtcaactt tgttccggga 326161 agcggagcgg aagtaggcga ctatcttgtt gaccatccga aaacaagcct tatcacattt 326221 acgggatcaa gagaagttgg tacgagaatt ttcgaacgcg cggcgaaggt tcagccgggc 326281 cagcagcatt taaagcgtgt catcgctgaa atgggcggta aagatacggt tgttgttgat 326341 gaggatgcgg acattgaatt agcggctcaa tcgatcttta cttcagcatt cggctttgcg 326401 ggacaaaaat gctctgcagg ttcacgtgca gtagttcatg aaaaagtgta tgatcaagta 326461 ttagagcgtg tcattgaaat tacggaatca aaagtaacag ctaaacctga cagtgcagat 326521 gtttatatgg gacctgtcat tgaccaaggt tcttatgata aaattatgag ctatattgag 326581 atcggaaaac aggaagggcg tttagtaagc ggcggtactg gtgatgattc gaaaggatac 326641 ttcatcaaac cgacgatctt cgctgacctt gatccgaaag caagactcat gcaggaagaa 326701 attttcggac ctgtcgttgc attttgtaaa gtgtcagact ttgatgaagc tttagaagtg 326761 gcaaacaata ctgaatatgg tttgacaggc gcggttatca caaacaaccg caagcacatc 326821 gagcgtgcga aacaggaatt ccatgtcgga aacctatact tcaaccgcaa ctgtacaggt 326881 gctatcgtcg gctaccatcc gtttggcggc ttcaaaatgt cgggaacgga ttcaaaagca 326941 ggcgggccgg attacttggc tctgcatatg caagcaaaaa caatcagtga aatgttctaa 327001 gcgggactaa atgggcatcc tccctgcggg ggtgtccatt tcatccatat actataaaaa 327061 agaggaggaa gtgccataga aaacacacag ctgattattt cgatttgtat ttatatggcg 327121 ggaatgctgc taatcggcta ctttgcttac aagcgtacgt cgaatctgac ggattatatg 327181 ctgggaggac gctctttggg tccggcagta accgctctca gtgccggcgc tgccgatatg 327241 agcggctggc tgctaatggg gcttccgggc gccatgtttt ctactggtct gagcggcgct 327301 tggatcgtca tcggactttg ccttggagcg tgggcgaact ggctttacgt cgcaccacgg 327361 ctgagaacct atactgaaaa agcggggaat tctattacaa ttcccggatt cctggaaaat 327421 cgcttcggag atcaaacaaa gcttctcaga ctgttttcgg gaattgtcat tttagtcttt 327481 ttcacgtttt atgtatcgtc cggaatggtg tccggcggcg tcttattcaa cagcatcttg 327541 gggatggatt atcacaccgg cctgtggatt gtgacgggtg ttgttgtggc atataccctg 327601 tttggcggct ttttggcagt cagctggaca gattttgttc aggggattat tatgtttgcc 327661 gcactcattc ttgtgccgat cgttacgttt ttccacacgg gaggagcagg tgatacagtt 327721 gctgaaatcc gctctgtaga tcctgatatg tttaatattt tcaaaggaac gagcgtcctt 327781 ggcattattt ctttgtttgc ctgggggctg ggatactttg gccagccgca tattattgtg 327841 cgttttatgg cgataacgtc tgtcaaagag atcaaaagag cgcgcagaat tgggatgggc 327901 tggatgattt tgtctgcagt aggcgcagtg ctgaccggtt tgggcggaat cgcttattac 327961 catcagcgcg gcatgacact gaaggaccca gagacgattt ttattcaatt agggaatatc 328021 ttgttccatc cgattatcac gggttttctg atttcagcga ttttggccgc gattatgagt 328081 acaatttctt cccagctgct tgtgacatca agctctctgg tagaagattt gtataagtcg 328141 atgttcagac gctcagcttc agataaagaa ctggtgtttt taggccgact ggctgttctg 328201 gctgtttcaa ttgtcgcgtt ggttctggct tgggagaaaa ataacaccat ccttggattg 328261 gtcagctacg cgtgggcggg cttcggtgca tcattcgggc cagttgtact gctcagtctg 328321 ttttggaaac gaatgaccaa atggggggca ctcgccggca tgattgtggg agcagcgact 328381 gtaatcattt gggcgaatgc cggtctttcg gactttctgt atgaaatgat acctggtttt 328441 gctgcgagtc tattatctgt cttttttgtc agcatattga cgcaggctcc gtcacaagct 328501 gtcacagacc agttcaacga ctaccaagat acaatgtcgc aataaagatc gaaaggagga 328561 ggaaggggct gtcccttttt cctcttttct ccttttaagc ggccattttt ttcttttgga 328621 aacaaacgta tttttttcta tacaaaaaga ccccgtatgg atatgattaa agtaaaaaaa 328681 gtataggaga aaaaggtatg gaagagcttt tagagagagt tttttcattt tcagatgttg 328741 ataagctaat tgattttatt agctatgaac tgcaaaagcc agtgatactg gaaagcgcgg 328801 atttcttttt gttagcctat aattcttact atattaacca ttttgattct gccaaccagc 328861 agactatttt ttcgaaaaag tgtccggtcc agatttttga gaggtttctg aaggacggaa 328921 ttattgaaaa attgaaaaca gagcctgagc cttttcgcgt caataaaatt gaaagcattg 328981 ggttaaacca gagggtggtc gtgagtgcaa agcacaaagg ggaagtcatg ggctacatct 329041 ggattcagga gctggaccaa aatctgacgg atgaagagct cgactttttg tacgagacct 329101 ccttccatgt cgggaaaatc atttataaaa cgaataaatt gaaacaggaa aaggaagaaa 329161 aagcagagga tctcatcaaa cgggcgatct atcagcaatt tacctctgag aaggaactca 329221 gacgggaagc tgaaaggatc aacaccgtgc tgccttccat gttttcagtt gttatcctgc 329281 acgccgcaaa tggggatggg gaagcggttg aggatttaaa ggaaaatatc aggtcgtacc 329341 tgaatttacg ggataaggtc agtcatgtct taacgatcga atcaaacatt gtcatcgtcg 329401 tagcgagttt ttcccaaaaa agctccgtct cctcagcagc ttctgagttt attaacaagc 329461 tgttaacaca ttttcacttt caaaaaatac ctacccctat ttatatcggt atcggaaacg 329521 aatataatca cctattaaaa cttggcaaga gctacacaga agcacttgaa gtcatcaaag 329581 ccgcagaaat caccggcaat caggaaaaca ttccatatga atatgccaaa ctcggcattt 329641 accgctattt agaaagcatc gaacagaaaa atgaattttt agaatacgag aataaagatt 329701 tagctttatt aaaagcaaaa gacgaagaaa gcagcactga gctgctcaaa accttggaaa 329761 tctatctcct caacaactgc aaaacaaaac cagcggcaga acagctgttt attcaccaaa 329821 atacattgaa ttaccgcatc aaacagatta ctgagatgac gtcgatcgat ttaagcgatt 329881 tcagaacgcg gtgccagctc tatctcgatt tgatgctgat gaaaaagaaa taaaaaagaa 329941 accagtactt gtactggttt cgtcttcact taaaatcctc tgtaaacata cggatcatca 330001 ggttttttaa tggtattcca gtcagttact ttgacgacag ggagagttga cttgaatggc 330061 tggtaatatt ctgaggccag agtgccctta atgtgaatcc attcatcatc cttgatgtcc 330121 atgtccttcg gaaattccac aagcatcccg tacacgccgg aatcagcgat acagtgaatg 330181 atgccaaacc ttaatacgaa cagctgattt ttgttaattg cgtttccttt gtaagcaaat 330241 ccatgaaatt ctatcgtccg tccgagaaat tcacccggat agttatagat ggtttccatt 330301 ccttttagga aatcgtcatc ggtcagagaa atctcttttt tgctggaata cttattaaac 330361 agctgtttca tttgtttgtc atagctgtct tgcgcgtaat aaaggctggc atcaggccgc 330421 aaatactgtg tttgggagta gtgatctccg ctctccatcg ccttaaacga gaaccctttt 330481 gttttgacta tggatgagtc aagcgttgca atcgggaaga agatgcctga caccaaagga 330541 aaaagaaaaa caacataaat caaataacgc tgataaaatg gcttgttttg ttcatggtca 330601 tgctcgtgat catggccgca cccgcaatca tggtcatggt gatgtccgct tttttcaggc 330661 gacttgataa atagatatgc ttggacggcg gtcagaatgg ccagcaggaa gatcgcaata 330721 aaggaaagat aggcatattt catattgata tattttgtta gatttcctga ggcatgcaga 330781 tgataaaaga aaaacgtaaa tcccatcagc accaataaac gaaacatcca atcacccctt 330841 taccagtagt gatcccgcta aaacaatcac gacaatgtat gtaatcagca ggaaaacaaa 330901 tcgttttttg aaggccgcaa gcatcatcaa tagattctta atatccacca ttgcaccaaa 330961 gacgagaaag gcgattaacg atcctaatga aaacgtgctg ctgaaggaag acgcgatgaa 331021 cgcatcaact tctgaacaaa gcgacaggac aaacgccaga cccatcatca cgagggaaga 331081 ggatacatca ttctgcccga tcgcaagcag agtggatgtt ttgacatacg tctgcatagc 331141 ggctgcgata aaggcgccga tgattaaata tttccccacg gagaaaaatt catcaatggc 331201 atgccgcaag gtcccgccca gtttttggag caaggtgccg tgatgatgat ggtggtgccc 331261 gggttcatca ggctttaaaa gctggttatc cttaaattga taggataaga tgaccccgat 331321 gatcagcgaa acggcgagag ccagtccgcc tctgtaaaag accacgctcc atctattccc 331381 gaacgcaata taagtagaaa ataaaacgat aggattaatg ataggcgcgg tcagcatgaa 331441 agcaacgccc gcatgcagag gaactccctt taacagaagc cgcctcgtaa tcgggatgat 331501 gccgcattcg caggcgggaa ataaaacgcc ggccagcgca ccgaataaaa cggcgagaaa 331561 acggtttttc ggcatgattc ttgcaatcat ttcttcagaa acaaacattt gaatgattcc 331621 ggaaagtatg acgccaatca gaataaacgg aatggcttct attaaaatgc tgataaaaat 331681 agaattcagc tgaagaaaag atgattgtgc tgtcacaata aaacctccgc tcatgttaag 331741 ctgcctttct tatgatacca gaaaaaaagg cactgcttgt ttgacggagg aggggaaagg 331801 atcgtttcac tttggttagg attccaaaaa gccgagtagg atactgcctg tttctgcagc 331861 ttcttttccg agccaaatca ggtgtcccca tgagtgaagc aaacagagaa cagcgccacg 331921 aatgtgctct tttgcatgat gtgcatgtga caagtcaacc aatccgtcat aaacactttg 331981 cataatcagc acgggacata tgatggcttg caggtctttt aaagagacag cggcggtttg 332041 tgacaagtca atcagaaatc cttcacccga gcgctgccgg ctgttcattt tccgaaatgc 332101 ttctatgtct ttttcattca tcaaggactt gattcgctga aacggaagcg tgctgaattg 332161 ggggctcata gctcgaaaca tcaaacgcgg gaaagcgtta ttcaaggaag aaatcagctt 332221 ccatatccac ttttccaccg gcgggcggaa gagaatttcc cccaatttat attcagtgtc 332281 ttttggggtg agccactctt tggtgactgc ggattgcagg gtcaatgtat ttactctttc 332341 cggataatgt gaggcaaagc atatgccgct cggccctcct gctgagatgg cgatcacatg 332401 gacactctcg atttgtagat gatctaataa tttcacatag aaacggcagg cattggcaag 332461 actttttcca atttcttttg acgtccgtcc atagccaggc cttgaaggcg taatgatgga 332521 atacccttgt tcaatcaacg ctgtgtatcc gaattcctcg taacaatttg aatgcccgcc 332581 atgcatgaca aggatcggag ttcccttgcc tgtcacagaa tattctagtg taccgccatc 332641 gaaggtgatc gtttcaactc gtcttttcat ctgtttcacc caattggttt ttgcctatta 332701 tagagttttc agcaattgac cacaaggtag aagaaatgaa taaacaaagg cccttgaaat 332761 atgatatact ttgtattgat attcattctc aattaaaact ttgatataga tgtgaacggg 332821 aggcaggacg gatggctgag aatcaagagg tatatgacgt tacgattata ggcggggggc 332881 cgatcgggct gtttactgct ttttactgcg ggatgcggga gctgaaaaca aaggtaatcg 332941 aatttttgcc gaagctcgga gggaaggtgt ctttattctt tcctgagaaa atcattcgcg 333001 atatcggcgg cataccgggg attgcgggaa agcagctgat cgagcagctg aaggagcagg 333061 cggcaacgtt tgatcctgat atcgtattga atcagcgtgt gaccgggttt gaacgcctag 333121 atgacggcac cattgttctg acgggttctg aagggaaaaa gcactataca agaactgtga 333181 ttttggcttg cggcatgggt acacttgagg tcaatgagtt tgacagcgag gatgcggccc 333241 gatatgcggg caaaaatctt cattatggag tggagaagct cgatgcgttt aaagggaaac 333301 gcgtggtgat atcaggcggc ggagatactg cggtcgattg ggctaatgag cttgaaccga 333361 ttgcggcgtc tgtgactgtc gttcatcggc gtgaggaatt cggcggaatg gaaagcagcg 333421 tgacgaaaat gaagcaatca tcggtgcggg tgcttacgcc ttatcggctg gagcagttga 333481 acggagatga agagggcatc aaaagcgtga ccgtttgtca tactgagtct ggccagagga 333541 aagacataga aattgatgag ctgatcatta atcatgggtt caaaattgat ctcgggccga 333601 tgatggagtg ggggctggag attgaagaag gaagggtgaa agctgacaga catatgcgaa 333661 cgaatcttcc gggcgtgttt gtggcgggcg acgcggcttt ttatgaaagc aagctgagat 333721 tgattgccgg cggatttacg gaaggcccga cagcggtcaa cagtgccaag gcttatctgg 333781 accctaaggc cgagaatatg gcgatgtatt ccacccatca taaaaaattg gtgcataaat 333841 aaaacagccc ttgaggaaaa gggctgcttg ccatcaggtg tgaaggagtt ttttctctgc 333901 atgttgattg tggatgaaag ctagcaattc atcctgttct tgtacggctg tgaatccata 333961 aatgccggca gctgagtcat cgcctatgca gacgatagga gggcggcttg ctgacggttc 334021 cggcaaaatg ccaatttgtt cgccaccatt gatcaattgc tgaacggaca gcttgtttgg 334081 gcaaatgacc atgtgcagcg gggattcact gatggtacgc tgaatcatgt gggtgaaccg 334141 gtcatctatg acgttttcat gagtgatata aaacgaacag gattcatgct tttgcatgtt 334201 ttccactgca tggcggctcc cgacaacaag acgtttctct gaatcaggct gaatggcggt 334261 gacaagaaag ccccgtttct caagctctgt ctttgcttgc tcagatgctg cactcagttt 334321 ggctgtcagc tggcggatgt cgattttctg agaagccagt gctctgaaaa attcacaaac 334381 cgcccggcgc gatgtgaaaa aaacgtcttc aaaggtgcca atctttcgaa gaatttcttc 334441 attgacaggc atgttttcgg tccgccattt cggccactcg atgagatcgg cgccggaatc 334501 gcgcagcttg tctgcaagcg ggtcttcatc ttcgccatga gtcacaacca tcaaatgccg 334561 tccgatgagc ggtttgcttt caaaccagct gtgtgtttga aagttgacga tgtctccgat 334621 gacgataatc gcagggtttg taatctggtg ttcctgcact ttttgctgaa tgttctcaag 334681 tgttcctttc acactccgct ggcggcccca cgttccccat tggatgacaa tgacagggac 334741 agaaggcgat ttcccgtatg aaataagctg ctggcaaata taagacaagt tcttgacacc 334801 catgtaaaaa acaagggttt gaacgcttcg ggccagccct tcccagtcaa ggttcggcgt 334861 gccttttaat gatttatcat gcgctgtaat catggcaaaa gacgatgcaa aatcccgatg 334921 cgtgacgggg atgcccgcat atagcggcgc tgcaattcca gaggtgattc ccggcaccat 334981 ttcatagcga atgccgtgct catgaagagc atctgcttcc tcgccgactc tgccgaatac 335041 gctcggatct ccgcccttca agcgaacgac ggttaaccca tttaatgctt tttcaaccag 335101 cagggcgtta atttcttttt gtttcataaa atggcggttt ggcagttttc cgcaataaat 335161 aaactggcag tccggtgatg caaattcgag cagcttcggg ttggcgagcc ggtcatataa 335221 aatcacatct gcttccttga gcgcctgttt tcctttgatg gtgagcaggc ctgggtcgcc 335281 gggtccggct cccacgaaat atacgattcc gttcttcatg atcatgtcat ccttccgtca 335341 ctgtaaaaaa tgaaggacca ctagaaaagt gatccggtct tttgatcaat atacgagata 335401 aacatgttct ccttcgatca gcgtttcata tgttttgacg catccgtggt caggttcttg 335461 gacgattccg tcttctaagg aaattttcca gtcgtgcatc gggcagaaaa catattgacc 335521 gctgacgatg ccttctgcca ggacgccgcc cttatgcgga cagcggtttt caatggcgcg 335581 gatgcttccg tctgaaagct tgaaaaccgc gagctcctta tcttcaatat acactgtttt 335641 gcctaattgt tcaggcaatt cttcaatttt tccgatacat acttttgtta cgtctttgtt 335701 taccatgtcc attcctcctc aatgatagtt tttgtcatta tgatgtggtc acgacatttt 335761 caaataattc tttagaggtt tgtttatcct ctaaaaagtc tttccacgga tccttgtgga 335821 cagagagtgt ttcattcatt cggccgttca gctcctgccg cttttccgga tcgtttaaca 335881 cggattggac atgggataaa ccgacgcgct caagccatgc ggacgtacgc tccagatagt 335941 ttgcggtttc cctgtaatat tgcaggtaag cgcccgcgta ttctaagact tcttcatttg 336001 ttttcacctt catcagcaaa tcgccggcac gcaaatgggt tccgccgttt ccgccgacat 336061 aaagctccca gcctccgtcg atgccgacaa cgccaaggtc cttaatgccg gattccgcac 336121 agtttcgcgg gcaggcagac acggccattt tgactttgtg aggcgtgttc agcccttcga 336181 attttttctc aagcgcaatg cccagtgcca tggagtcttg tgtgccgaag cggcagaatt 336241 gctcgcctac acatgttttc actgtgcgga gcgtttttcc gtacgcgtag cccgatggca 336301 tatcaagatc ttcccatacc ttcggaaggt cttctttttt cacgccgata agatcaattc 336361 gctggccgcc tgtcattttc acgagcggga tctcatattt gtcaacgaca tcggcgatct 336421 tgcgcaaatc tgtggagttg gtcacgccgc cgtacatccg aggaacgact gagtatgttc 336481 cgtctttttg aatattggcg tgcattcgtt cattaacaaa gcgggatgtc cggtcatcct 336541 cgtatttggt tggattgatc atgcctaagt agtagttcag agcgggtcgg catttagaac 336601 agccttctgg cgttttccag ccgagcacat tcatgacttc tcttgtatgt gacagccctt 336661 tggctttgat ttcttctacg acttcatctc tcgacaatgt ggtgcagccg caaatggctt 336721 ctttttgcgc tgacgcatca aagtctgatc cgagcgtatg ctggaggatt tcttctacga 336781 gcggcttaca gcctccgcat gagcgggatg cgccggtgca tgctttgatt tcgtccgttg 336841 acgagcagcc cttttcctgt atggcttgaa taatcgcacc ttttgacacg ccgttacagc 336901 cgcagatgat ttcatcgtcg ctcatcgctg cggttatgct tgtgcctgct tcctggctga 336961 ggggctgtaa gattgatatt ttagaggttt cagagatatc ggcttctttt tgaatcatag 337021 aaaacaggcg attgccttcg ctgctgtcgc cgaataaaac agcaccgaca atttgattgc 337081 ctctcaggac aattttttta tagatgccgt cctgctcatc gaagacttta atcgcttttt 337141 tctcctctga ttcgttaaag tcaccggcag agaagacctc gacgcctgat acctttaact 337201 gtgtggagag aacggagccc tcatacggtt ttgtttcgat gccgcacata tgctttgcca 337261 gcacttttgc ctgttcatac agcggcgcca caagcccgta ggcgattcct cggtgctcgg 337321 cacattcgcc gaccgcgtaa atgtgcggga tttcagtctg catataatcg ttgacgatga 337381 tgccgcggtt aaccggaatg ccgctctcgg ccccgagcgt tgtatttggg cggatgccga 337441 cagccatgac gactaaatca gcttcaatgc ttgtgccatc cttgaatcgg aggccttcga 337501 cacggtcgtc accgacaatt tcttctgttt gcttttcaag taaaaaggtc ataccttgtt 337561 tttctaactc gttttgcagc aggcgtcctg ccgttgcatc aagctggcgc tccatcagga 337621 atggggcaag gtggatgacg gacacgtcca tgccgagatt cagcagtccg cgagctgctt 337681 ccaaaccaag tagtcctccg ccgatgacgg cagctttttt atattgtttt gacgcggcga 337741 gcattgtgtc tgtatctttt atgtcccgga aagctgtgac gccttttttg tctgcgcccg 337801 gaatcggaag gataaaaggg accgatcctg tcgccaggat caattcatcg taaggctgga 337861 ttctgtctgc atctgtgatg actgttttgt tttccgtgtc cactttgatg actgtttcat 337921 ttgtatacaa ttgaatgttg ttttcttcgt accagtccca atcgtttaac gtaatatctt 337981 taatatctgt atcgccttga agcacttttg acaaaaggat tcggttgtaa ttgggatgcg 338041 gttcggcacc gaaaattgtg atctgaaact cgtctttagc aacactcagt atctcttcaa 338101 tggcccttac cccggccatt ccattaccaa caagaactag ctgttttttt cccatcagat 338161 gatccgctcc ttatcaaatg ttttttccag cgtagcacag caaaaaggaa tatttaagat 338221 acatgttata aaatgtaaca aaatatacga aaagttctaa aaattttatg aaaaatttaa 338281 ataggtatga ttcggacggc gcatacctta aaaccgggca ttttacaggc tggatctaag 338341 gcttccccga ttaaatcatt cacattttga gcgtctgccc aatggatggg aacaaaaacg 338401 gtatcttttc tgatttgttc tgataatttg ctgcggacgg tgatgcttcc ccgcggcgat 338461 tctattttta ccagtacacg gtcctcgata ttgtaggtcg ctgctgtttg cggatggatc 338521 tccataaacg attcaaaatg tctcgcggca agggcggcgc tttttcttgt ttggacgcct 338581 gttaagtagt gagacatgac tctgcctgtc gttaaataaa gcggataatc ggctgtcggc 338641 ttctcttttg gaacaggtgg ttcgtttgga atcacactta atgccgcttt ttgatccgga 338701 tgagcaaatg attctgtaaa caagcgccca gttccgggat gatcagattc cggacacggc 338761 caatgaatgc cgccttcacg tctgagcctg ccgtatgaga tgcctgaata atcggcaatc 338821 ccgcctcggc tcgcttctct caattcattg aaaatatcct ccgctgacgt ataagaaaag 338881 tagcggccct tgccgagagc ggatgcgaga tcacaaatga tctgccaatc atgctttgct 338941 tcgccggggc atggccggct tgcttctctt aatgtcacgc gtccttctac atttgtcatg 339001 gtgccttcat cttctaagta agaggaggca ggtaaaatca catctgcgta tttcgcagtc 339061 tcagaaataa acaaatcgat tgcgacaaag aatgtcagtc ttcttaaagc ctttttcacg 339121 agatttgcat ttggactgga aacagcaggg ttggagcaca tgaggaacag tcctttgatg 339181 tcgccgtcat tgattttttc catcatttca taggctgaga caccttttcg cgggagttca 339241 tcctgatgga ttccccacac tttcgcaata tgcgcccggt gttcttcgtt ttcgatagaa 339301 cggtagcctg gaagctgatc ggctttttgg ccatgctctc tggcgccttg cccgttgcct 339361 tgtccggtga tcgccccgta gcccgagtaa ggtttgccga tttttcctgt gatcagcacc 339421 atgtttaaga agcctttcac agccgctgtt ccatcggttt gctgttcaat cccgcgggct 339481 gtaaacagca tgccggacgt ttccttggca aacttcacag cagcttttct tatatccacc 339541 agcgagacac tcgtctgttc ggcgatgtca ttcaggtcca acgagtcagt atgctgcttc 339601 agctcttcga atccatttgt tcgtgattga atgaaatcct cgtttataag ctgttcgtca 339661 atgatgattt tgacgagacc gttggcaagg gcggcgtctg tgccgggttt gattttcaga 339721 tgaagatcgg cgattttcgt tgtcgctgtt tcacgaggat caatggcaat gaagtaagct 339781 ccgttttctt tcgctttttc aaaatacggc ataatcgtag gctggcattc cgcaatattg 339841 gtgccggcca gaatgatcac acgggtgtgg gggatgtctg ataaaggatt cgttaagcct 339901 ctgtccgcgc cgaatgtttg gttggctgcg gtggctgctg cggacataca aagtctcccg 339961 ttgtagtcga tgtattttgt ctgtaagcct actcgtgcga acttccctaa caaatacgcc 340021 tcttcatttg taatcgaggc gcttccgtat accgccatgg cgtcatgtcc gtgttcagtt 340081 tggatcattg tcacttggtc tttgatatga ttcagtgctt cttcccagga aacaggcata 340141 aactcgccgt ttttcttcag cagcggccgg gtgatgcggg aggagttcaa ggcatgctgg 340201 tgagcattca tgcccttgat gcatagccga ccctgtgtcg taggattatc aatcccgatc 340261 gcagtgtact ttttgcgcgt gacgatggtt tgttccacga gctgcatttt gcactgcatg 340321 ctgcaaaacg ggcattgagt gtcatatgtt ttttctgatt ggacgtcttg ctgtttatca 340381 cggaaatatc taagcagtcg ttcagtcaaa atgcctcatc ctttcttata tgcgcccgtc 340441 tctacagtcg ggttttgaat cagtgacaga tctgtttgga ggctttccag cagctgtgcc 340501 cttaggtctt cttcgaatag cacttctctg atatgaacga tcccgagacg gtctatccac 340561 tgatgaacac cttctaagta atgagccgtt tcccgataat actggatcag tcctttgatc 340621 atgccggcag tgctgtcttc gttctcagtc acgcaaaaca aagctcctga acgggcatga 340681 gttccccgga cgccgccgat gtgaatgtcc cagccagctt gtgtccgaat tgcgccgaca 340741 tcttgcaggg cggcctcggt gcagtctgtt tcacatgata agctgataga aatgggagcg 340801 ggtaagggaa gcatctcaag ttgtctttcg atttgggctg ccagctgctg aatcgatcga 340861 ttttgcccgc atgtacatgc tttgatgctt tgcagcgcgt gtcggtgttc attagtgtaa 340921 acgggcattt tcaggtcttt tttcatgttc gggagatccg caggcttgat cccggaaagc 340981 ttcagccttt ggccgtgagt gatggatacg tcgggaatgc tgtatgcctc aatgatgttg 341041 gcgatggttc ttagctgctc cgcgtttgtc cgcccgccgt acatttgcgg aatcaggatg 341101 catgtctctt cagtggctgg ctcaggctgg acaaacccag ggtacagcat ttccagatag 341161 tattgaatcg caggaacaca agtactgcat ccgttttttg ttttccagtc aagctggttc 341221 atcacttctg ccggattagt gaatggcctg cgctgaagct cagcgatgat gtcgtcttct 341281 gtaaaatcag tacagctgca aaacgaaggt gtgctggcgg gcttcgtata ttcgctgttg 341341 gtcatgtatc tcaaaaggtc ttcaacgagc ggtttgcatc ctccgcagga cccagtggct 341401 ttggtgcagt gcttgacttc ctcaacagtt gttaagctat tcgtgtgcac cgcgtcttca 341461 atcgcgcctt tcgtcactgt gttgcattgg caaatcgttt cactggaagg catggattca 341521 aataaagggc cgcttgtctc cggttcgatg atctgttttt tggcaatgga gatgtctcgt 341581 tgtttaagca ggctgtcgag aagccgctgc ttgtcacggg tgtctccgaa taaaataacg 341641 ccggccagtt tgtcatctac aaaaagcgct tttttataaa cgcctgcttg ttcgtcgtag 341701 attttgatgc tcgtcgtgcg ttcatcctct tggatctttc ctgctgacca cacatcgatt 341761 ccagctattt ttaacgccgc agatggtgct gagccttgat attcctcaca tggaacgccg 341821 caaatatgac tggcgagcgc ttttccctgc tcataaagcg gagccaccaa tccgtacacc 341881 gttccgttat gctcagcgca ttcaccaacg gcgtagatat tcggttcgct tgtctgcatg 341941 aagtcattca cgatgatccc gcggttcact ttgattccag cggatacagc caattcaata 342001 ttcggtttga cgccggccgc catcacaatc aagtctgctt ttaatgaaga gccatcttta 342061 aaatggattc ggtctgcctt cgtggcgccg gaaatggaga cggtgtcttt ctccaaaaga 342121 aaggttaggc ctttttgttc cagctctgtt tgcagcagcc gcgccgctgt ttgatcgagc 342181 tgtttttgca taatgccggc ggagtggtga atgacgctga catccatacc gagatgctgt 342241 aaacctactg cagcttccag tcctaataag ccggctccga ttaccgcagc cttttgaaag 342301 tgctgggcca tgttcatcag cgcttggcag tcttctattg tccgaaatcc atagacacct 342361 tttttgtctg ccccggggat agggagaata tgaggggagg agcctgttgc cactattaat 342421 ttgtcatacg acagagtgcg tttccgatct gtgatgacct gctgctgatc tgtatcaatc 342481 tgaataaccg tttcgcctgt gtaaagcgtg atcccgtgct tgtcgtacca atccttgctg 342541 ttcagtgtaa tatcatcgag tgacgcttca ccctgcaata cagaggataa gagaatgcga 342601 ttgtaattgg gatgcggctc gcttccgaaa atgacaatct caaacatgtg gcgattcagc 342661 tttaatactt cttcaataca gcggattccg gccatgccgt ttcccgctaa cactaatctt 342721 tgtttcttca tgtatcagac ctcctttggc gaagctcgta agttttctcc tattaaaaat 342781 tatgtcacaa tgcattgtta acgcattaaa cgtgtcacaa aaacttacac atgtcttttc 342841 cagaaaataa tggtcctata tccttgattc agaaaatgta aaataatgag ggtctagaaa 342901 ggggaatctt atgaagctgt cggaactgaa aactagcggt catccactca ctttgctctg 342961 ttccttttta tactttgatg tcagttttat gatatgggtt atgcttgggg cgctgggtgt 343021 ttatatttct caggattttg gcctgtctcc ttttgagaaa gggcttgtcg tagctgtgcc 343081 gattttatct ggatctgtgt ttcgtatcat tcttggtatt ttaacggaca gaatcggacc 343141 gaaaaaaacg gcagtgatcg ggatgctggt gacgatgatt ccgctgcttt gggggacatt 343201 cggcggccgt tccctgactg agctgtatgc catcgggatt ctgcttggcg tggcgggagc 343261 aagctttgct gtagcgctgc ctatggccag ccgctggtat ccgcctcatt tgcagggact 343321 tgcgatgggg attgccggag cggggaacag cggcacgttg tttgcaaccc tgtttggccc 343381 tcgtctggca gagcagttcg gctggcacat tgtcatggga attgcgctaa ttccattatt 343441 gatcgtcttt attctttttg tatccatggc aaaggattcc cctgcacagc cgtctcccca 343501 gccgctcaaa agctatctgc atgtgtttgg gcaaaaggaa acatggtttt tctgcctgct 343561 gtacagcgtc acatttggcg gatttgtcgg gctctcaagc tttttatcta ttttctttgt 343621 tgatcaatac cagctgtcaa aaattcacgc aggggacttc gttacattat gtgtggcggc 343681 ggggagcttt ttccggcctg tcgggggctt gatttcagat cgtgtcggcg gcacgaaagt 343741 tctttctgta ttgtttgtca tcgtggcact gtgtatggcc ggagtcagta gcctgccatc 343801 tctctcaatg gttattgttc tattgtttgt cggaatgatg gggctcggaa tgggaaacgg 343861 cgcagtattc cagctcgtgc cgcagcgctt ccgcaaagaa atcggcatgg tgacgggaat 343921 cgtcggtgcg gccggaggaa tcggagggtt tttcttgccg aacatcttag gatctctcaa 343981 acagatgaca ggcacatatg ctatcggttt tatcacgttt tcctgtatcg cgctgctggc 344041 gtttgcactt gtgcttgccg caggctatta ctggcggaaa agctggagcg cggaaagcag 344101 cccggcggat gtttaggatt ttgacggaca cgcgtttgtg cgtgtctttt ttattttctc 344161 ttgattttca acagtgaacc gatcaaaata aatagtaatt attacgattt gttagtgaga 344221 ggagttttct gaatgaatca acatacgctg ctcccgaaaa aaacggagcg tcttcaatac 344281 tttggatcgg tcagtccgat caaaggcgag aaaccagtgg aaaaagagaa aatgaaggac 344341 ctgcaaaata tcaggaagga ttattttttt gacattcagc atgtaggtgt agctaatgtg 344401 tcccatccag tcacaatcac ttctgccatg atgcctgccg agcaaacaac ggctgcgaac 344461 tttacaatga cttgtaattt gccgagaaat cagaagggga ttaacatgag ccggttaaca 344521 gagctgctgc aagtctatca tcaaaatggc tggattctct cattttcctc tcttcagcaa 344581 tttacgaaag agcttgcaga aaacatggac acatcatctg ccacagttga agtgaggttt 344641 ccgtggtttt tcgaacggaa aagcccgaag cttgagaaag cgggtttgat gcatgctgat 344701 atattcatgt ctgtcaccta tcgcaaagat cagccgttta aacagcgtgc cggcatctca 344761 gcaaaagtaa cgactctgtg cccttgctcc aaggaaatca gcgaatacag tgcccataat 344821 cagaggggaa cggtcagcat ttgggcggat attcacccgg ccgcatcgct gccaagtgat 344881 gttaaagctg atttgcttca cgccgcagaa tcaaatgctt ctgcgagact gcatccggta 344941 ttgaagcggc ctgatgaaaa agccgtgaca gaaacggcct atgaaaaccc gagatttgtt 345001 gaggatctcg cccggctgat tgctgcagat ttgtttgagc ttgaatgggt gtcagccttt 345061 gagattgaat gccgaaatga agaatcgatc catcttcacg atgcctatgc gaagctgtgt 345121 ttttcgaagg aagtggataa aatatgaaac tctcattatt cattattgca gttcttatgc 345181 cagtcatcct gctgtcagcc tgctccgatc atgcagaaga acacgcaagt atcaatacaa 345241 agaaaacggt cgaaaacata acggacgttc gaaaaacagc aaaaacaagc attgattgga 345301 caaagccttc gggcggagaa tacccggata ttaaacagaa gcatgtctgg attgatgtga 345361 atgtgaagga gcagaaggct tacatcaagg aaggaagcaa caccatctat acaatgatga 345421 tttcttctgg tcttgatcaa acaaaagatg atgctacgcc aaagggcacc ttttatgtag 345481 agcctgaacg gggagaatgg tttttctccg aaggatacca ggaaggcgca gaatactggg 345541 tatcatggaa aaatcacggt gaatttttat ttcatagtgt gccaatgact aaggatcaaa 345601 aagtcatcaa aacggaagca gaaaaactag gaacgaaagc atctcacgga tgtatcaggc 345661 tgaccattcc agatgcgaaa tgggtatatg aaaatatccc tgaacataca aaagtggtga 345721 tcagctgaat tgaaaaccgt tgacaaaaag gaaaaaagac catacaattt aaatcgtaac 345781 aattacgttt tatgataaat ggcttatcat tgtctgtgca tctgtgaaaa gcggaaaggc 345841 atcgattaag gatcttgctg tcggcaaagg caaggatttg cgatggggaa aaggattaaa 345901 cgcggttgga gtctttactg atttagaaat cgggcggcag cgagaaatga gcgcgaaaag 345961 ctgctctaca ccattgtaca tacggcgaag tattcaattt aaatcgtaat cattctattt 346021 taatggaggc actattatga aaaaaattcc ggttaccgta ctgagcggtt atctcggtgc 346081 gggaaaaaca acattgctga acagcatttt gcaaaatcgc gaaggcttga aaatagcggt 346141 tatcgtaaac gatatgagcg aggtgaacat tgacgcgggc ttggttaagc aggaaggtgg 346201 cctttccaga acagatgaaa agcttgtgga aatgtcaaat ggctgcattt gctgcacgct 346261 tcgcgaagac ttattaattg aagttgagaa gctggcaaaa gacggacggt ttgattatat 346321 cgtcatcgaa tcgacaggaa tcagcgaacc gatcccggtg gcccagactt tctcttatat 346381 cgatgaagag atgggaatcg atcttacaaa attctgtcag ctggatacga tggtgacggt 346441 tgttgatgcc aaccgttttt ggcatgatta tcagtcaggc gaaagccttc tggaccgcaa 346501 agaagcattg ggggaaaagg atgaaagaga aatcgccgac ctcttgatcg atcaaattga 346561 gttttgcgat gtactgatct taaataaatg tgatttggtc agcgagcaag agctcgaaca 346621 gcttgaaaac gttcttcgta aactgcagcc aagagccagg ttcattcgtt ccgtcaaagg 346681 aaatgtaaaa ccgcaggaga ttttgcatac agggttattt aacttcgagg aagcgagcgg 346741 atcggccggc tggattcaag agctgacggc aggccatgcg gaacacaccc cggaaacaga 346801 agaatacggt atctcttcat ttgtatataa gagacgtttg ccgtttcatt ctacacgatt 346861 ttaccgttgg ttggatcaaa tgccaaagaa cgtggtacgt gccaaaggaa tcgtctggtg 346921 cgcatctcat aacaacctcg ctttgctgat gtcgcaagca ggtccgtcgg ttacgattga 346981 gcctgtatct tattgggtgg cggcgttgcc gaagcttgag caggagcaag tcaaacagca 347041 ggagccggaa atcctggagg agtgggaccc ggagttcggc gaccgcctaa cgcagctagt 347101 ttttatcgga actgacctgg atgaagaaac gatcacgaaa gagcttgatc aatgcctgtt 347161 gactgagtat gaatttgatt ccgactggtc gctgtttgag gacccgttta aatggaagct 347221 gaatcaatag aaaaaaagcc gtcccatggg gaacggcttt ttttaatgaa acgtttgttt 347281 aaacataatg agcgtatttt ttctcaagga tattctgaaa gaccgcggca atggagcaga 347341 tggcccaata aatgagagcg gtcagaatat acatggtcat ataatcaaac tctctgcccc 347401 cgatgatttt cgcatgctgg agcaattccg gcactgtaat catcgcagcg agagaggacg 347461 ccttgatcaa gtcgagcaat acattggcaa gcggaggcag cgcaatacgt atcgattgcg 347521 gcaaaatgat gcccctcatc gtctgccaat aggaaagacc cagcgaggat gcggcttccc 347581 actgtccttt ttcgacggat gaaatggctg aacggttaat ttccgcaatg taggcggcgc 347641 tgtttaggct aaagccgatt aaagcagccg tgacagcgga aaattcaatg ccgatataag 347701 gaaacccgaa ataaaggata aacaaaatca ccaaaatcgg aacgcctcgc ataaatgaga 347761 tatagagctt cgccggccat cttaacaaag caagtttaga cattctggcg agtgatatga 347821 acaggccgat cacagttccc gcaaacatgc ttacaaaaga gatgagcagt gtataaccaa 347881 tgccttttat gacataaggg aacgattcaa tggccagctt cgtgttgaaa atatattccc 347941 actgaatgct attgatcatg gcgtccgatt acaaatcaac gtcctgaacg tcggcatcaa 348001 ttttttttga tacatctgct ttattgaaga attgtttcga cagtttagtc aaagagccat 348061 ccttgctcat ctctttcaat gcttcgttca tctttttctg aagtgccgca ttgctttttt 348121 tcatgacaag ggcctgtttg ttcggcatgt acttgatgtc aggatgaatt gtaatgttga 348181 gatccgggaa tgccgcgagc gcaagtgtct gcaggtaata gtcgtttaaa atgacgtcag 348241 tgcgtccgtt ggcaacatct tttaaatatt gctcattcgt cgcattatca taaatcactt 348301 ctttggcgcc gtattttctc gcgacctcca tgtagacggt tgtagccgcg ccagccgctt 348361 tcttcccttt taaatccttg agcgttttaa tccctgataa atcgtctttt cggacaattg 348421 ccgtgccgta tgaatattta tatggagtgg aaaatgcgaa cttctcctca cggtccttcg 348481 tcacatcgat gtcattcgcg gctgcgtcaa cctgtccgct gttcaccgct gtcagcatcc 348541 cgtcaatgcc catctccttg aactcaacct tcagccccaa gcgttttgcc gcttcacgaa 348601 caacttcaac ctcgtagccc gtcagcttat cagagccaga gtcagtatcg tgataagaag 348661 tgggatagag cgtacctgat gtagcgacta cgattttccc tttatcctta atctgctccc 348721 agcctgtatc cttggaatcg gcttcatttt tgccggaaca ggctgccaat ataagaaaga 348781 aagccattgt gaaactgaat ataacggctt tggaatgcat gaatgatttc acctatagtt 348841 cccccaatct gttaatcaac taaaaagata gcattgaaca taaggggttg caatatgttg 348901 atcgcgtttt caaaaagttc gaattgtgta tacaaaaagc atgggtgggt gtttaaaagc 348961 gtctatgaag ggaagaggtg atgaaaaaag gaattgtcca aggatgaatg ccagacgtac 349021 caaggaaacg catgtgaaag tgaaggatgc agcagacccg tcactcatct atgccaatac 349081 cggaagaaat ggtcaagagg catgaaaccg atcttcagaa taaatttaag tcttgctgat 349141 gcccctaagg catatgatat attcgatgag aaagaaaatg gaaacattta aaccataatg 349201 gggagtcaaa tgaatattta caaaccagcc ggattttgga tcagacttgg agctgcattg 349261 ttagactaca ttatagtctc cgtgccgctt ttgctgatct attggctgat tacaggaaaa 349321 gacccaaacg acagcatgtt catcagtttg gttgttctgc tgtattctat tttgctgccg 349381 atgttttggc gcggttatct tatcggaaaa aggatctgcg gaatcagaat cgtaaaaaaa 349441 gacggatcac aggtcagtct gttaacaatg tttttacggg ttattgtagc cggcctggtt 349501 tactgtataa ccttcggact cggcttgatc gccagcctga ttctgattgc cgtacgagaa 349561 gacaaacgga ccctgcatga tttaatcgcg ggaacatatg tcacttatgc gacaccaggt 349621 gaagaggaac ttaatgctga cgaagagatt agaaagagcg aataatggtt cgctcttttt 349681 atttttatgc ataaaaaata caaggcagca aaacatatga aaaataggat tggaggaata 349741 aaatggatga aacgaataac catcaacatt atcacaatgt tcattgcagc ggctgtcatt 349801 tctctgaccg gtacagctga ggccgctgaa aaacagcagc agtctcccgc aaatgttaca 349861 ctgacagatc agcaaaagaa agagattgaa caactggaag cagagattct taaaaagcgc 349921 aaagacgtga tctcaaagta tgtacaatac ggtatcctgc ctaaagaaag aggagaacac 349981 atcaaaaatc acttggacaa acactttgaa atgatgaaac aaaacggctt tgttccaaag 350041 caccatcctc atccgcataa atttgaaaaa agacattaag attttaagca tccaatggga 350101 attgggtgct tttgcgttat ttacaggtag gcaatattag ctgagctgtt ccgcgactaa 350161 catcgagttg atatgaaacg cgtttcatag cctatgatag gtttatcaaa taattcagga 350221 gtgataaaca ctatgatcca ccagcatcca gaatcttttc cgaaacattt tttgtggggc 350281 tctgcttctg cagcgtacca gattgaaggc gcttggaatg aagatggcaa aggcccttct 350341 gtttgggatg tgtttacgaa aataccgggc aaaacgttta aaggaaccaa tggcgagatt 350401 gcggttgacc attatcaccg atttaaagaa gatgtcgctc tgatggctga gatggggtta 350461 aaagcatatc gattttccgt cagctggcca cgggtttttc caaaaggaaa aggagagatc 350521 aatgaagcag gtctagcgtt ttacgatagt ctgattgatg aattgctttc tcatcacatc 350581 gagccggttc tgactttata tcactgggat ttgcctcaag cgcttatgga cgaatacggc 350641 gggtttgaat ccagaaacat catagaggat tttaatcact actgtattac tctttataaa 350701 cgttttggag acagggtgaa atattgggtt acgttaaacg aacagaacta caattttaat 350761 cacggattta ttacagccat gcatccgcct ggagtgaaag acagaaaacg attttacgaa 350821 gcaaaccata ttgcgtttct ggctaatgca aaagccatcg aatcatttag agaatatgtg 350881 cctgaaggca aaataggtcc tagctttgct tattctccgg cttacccttt atcaagtcat 350941 ccagaggata tactggcatt tgaaaacgcc gaagaattta cgaacaattg gtggcttgac 351001 atgtattgct ggggaaccta cccgcaaatt ccattccgct gcttggaaaa acagggatgg 351061 gcgccgacaa ttgaagcagg agatatggac ctgctcgcca aagggaagcc tgattttgta 351121 ggtgtcaatt attatcagac gatcacctat gaacgaaatc cgcttgatgg tgtgtcagaa 351181 gggaaaatga atacgacagg ccaaaaggga accaatcagg agacggggat acccggagtg 351241 ttcaaaacga aaaaaaatcc gcatctgaca acgagcaact gggattggac aattgaccca 351301 attgggctgc gtatcggtct tcgccgaatt acaagccgct atcagcttcc agtgtttata 351361 acagagaacg gtttgggtga atttgataaa gttgaggacg gcactgtaca ggatgattat 351421 cgaattgatt atttgcgttc gcatcttgag caatgcagac aagccatcag tgacggtgtc 351481 gatttaatcg gctattgcag ctggtcgttt actgatctgt taagctggct gaacggctac 351541 caaaaaagat acggatttgt atatgtcaat cgtgatgaag aaagcacatc cgatttaaaa 351601 cgcttgaaga aaaaaagctt ttattggtat caagatgtca tcaagacaaa cggagaaagt 351661 ttataaagag tccctgagag ttattctctc aggggttttt cattacacag aaacagcatc 351721 aataatataa gtgtcggcgt gcaaatctga catttcagcc ggcacagtcc agcatgtcaa 351781 ttgatagtct cctttaggca gatcaaagga cagtctttta gacatgatgc tttcaatatg 351841 aattccgttt tctgtgacat gaaaaggaac agtcactttt ttttcgtagg agtttactgt 351901 ttctgaactg ttcaggcgaa aaagaataaa ggcctttgta tttcgctgtg cctcaaagga 351961 aatggctccg tctgccgcag catatccttt ttcaatcgct tcgtcagtcc aatccattac 352021 aggaggtgta gaatcctttt gaaatacagt aaattgatga tatgaaatcg aaagttcttg 352081 cggcttccat gatttgatca atgtgctgtt cctcctctat gtactgttta ctgaattgtg 352141 aataaaacct ttgtgccgtc tgggtaatcg gtaagccgat gcccgaccca agagcctgct 352201 ccgcggttgt cagcgggaga aatgtattct acagaagctc cctcaccgcc ttctttgcac 352261 atggccattg gccattcatc tctgtcatac ccctttttgg aaggtacgtc ctttaatgat 352321 tgctcgcggc gttcttcagc tccgtctctg tcaatagtgc acacctctga gtgcccctca 352381 tttatcgcat ccttaatatg cttggcagtt tcgggatacc ggtcagatgg gaaggccatt 352441 gtttcatcat attctttcgt ttgagacgtt ttttgatcag ctgagaaaaa gtctcctttt 352501 atcaggccga cagctgcagc tgctatgatg acgatgacga gaagtatcgt ttttatgatg 352561 tccgtcgtga tgttcacctc ccgcttttaa aactgacaca agagtaatcc agaaagcatt 352621 tggtgtaaag gtttaaattt tatgttttac gatcagttta ttgcagaaat cgtaatttta 352681 gcagatcgaa atatttgttt tcagcaaaat acgattgcca atttacaata atgatagtaa 352741 gtcatcagcc gttttcggct tgattaatca ttttaaattg gcttatgata ccggtaagct 352801 cctcagctaa ttgagaaagt gtttcagaag ctgcggtaat ctcctccatt gcagcaaatt 352861 gctcctctgt taatgcagcc gcttgccggg tatttttagt agattcttta atgtcggccg 352921 tattggctgc aaaggaatca tttatttgat gtgcactggc tgaaatgttt gttacagatg 352981 ctgataaatc actaatctcg gcgctgattt cacctgttgc agctgcaatt tccttaaatg 353041 catctctggt gcgctggatc atggtgactc cttctgcagc ttctgttttc acatgctcaa 353101 cagatcttgc agaccggttc atatcctttt gtatttctat gatcagtttt gaaatctgcc 353161 ccgcagactg ttgagactct tctgctaatt tccgtacttc atcagcaaca acagcaaagc 353221 cttttccttg ttcaccggct ctggcagctt caatcgctgc attcagcgca agcaggtttg 353281 tctgatcagc aatttgggtg atgaccgata aaatttgctc aatttgttta gagcggccgt 353341 ctaactggtg tatgatttct ccgcttttct gaattgactg gtgaatcgca tccatttgcg 353401 cctgtacatt tgcaatttcc ttttgtccaa tgtctgcttt tgattgagcg agctgccctt 353461 tgtcagcgat agcggcagta tttgcagaaa tatcccggat gtctgctgaa gcttgtttta 353521 atgagctttc actattttca attcgggtga tctgatcttg ggctccattt gcaatctgct 353581 gtacagcttc tgtgattttt tctgaagctt gatttgtttc ctctgctccg gctgagagct 353641 gctgagaggc tgacgcaagc tgaagggctg attgttgtac ggtttgtatg gtatcgttca 353701 gcttcattct catcttatta taatagacgc ttagttctga aagctcgtca ccggttttgt 353761 ctgacacctc tattgtcata tctccgtttc cggcactttc aaaggcgctt tttaaagcgt 353821 tcagccgctt gttgattttt ctggtgaaaa ccaagacaag gatgactgat accataatga 353881 cgataacaag aacgatagcg aattgagtga aaagtgattg tgtaagtgat gctaaaatac 353941 tttgattagc tccggtatac agcatgccga tgatgttccc attttgatct tttaacggca 354001 tgtatgcagt ctgataagaa gaacctgcta catctgcttg tccgtaaaaa cgctttcctt 354061 tctttaaaac agcggcaata acttcagaag aagcctgggt gccgacggct ctttcgccat 354121 ttttcatgac attggttgca acacgagtat cgccttggaa aatggtaatg gtatcacctg 354181 tcttttcacc aagcagatca acaatatctt catttccatt gatttgtgtt tgccctttat 354241 agagcttatt gtttttcacc tgccagtcgc ctgacatgac atcatcaata taagtgctgc 354301 ttaaagcgag atcacctttc gctttttcag ttgccatttg tttcatgctt tctgtaattt 354361 ccttaagcat cacagtgcca actgatgccg aaaacaaaag aatcaccacg aaaacgaggc 354421 aaagaatttt agttcctagc ttcatcttaa atcgttttat caacataatt cctcccttta 354481 cgatttgcag gtcatattac ttatcgggtt tttgggttta aagttttatt ttagaaaaaa 354541 taaaaccggc ctgatcttca ggccggttgt gtgatgctat tcaaggtttg cgtggtgagt 354601 gaacatagtt tcagaatcga gacctttttt ctccatgagt tttaaaatca ctgcatcata 354661 gaagagcagc aaagtttgtt caaataatga tcccattggc tgaatggttt tatagcttcc 354721 gttagactgg tctttagggg aaccaggcat tctgatgatg aggtccgctt gttttccgat 354781 gcttgattcc ggattgatgg ttaaagcggc aacaattccg tgtaagcttt ttgcttttgc 354841 tgcggtatga atcaagctct ttgtctcgcc tgatcctgag ccgataataa ctagatctcc 354901 ttcggcgagc ggcggagtga gaatctcacc tactatatgg gcgttgaagc ccatgtgcat 354961 cagtctcatc gcgaaggatt ttgccatcag gccagaccgc cccgcacccg cggtgaaaat 355021 ttggtgggat gaaagaatgt gatcggcaag ctggtcagct tcttcattag aaatataagc 355081 tgctgaattg tgtaactcat tgagaatttc cgctacgtat tcagtcgttt tcatcggagt 355141 tatccttgga caatcagctg cttcattttt gaagctgttt ccgccttatc agctgcgctt 355201 gtaattccgc ccccgacaat gacaaggtca ggcttttgct ggatcacttc tggcagtgta 355261 tcaagtttga tgccgcccgc gattgcggtt tttgcgtttt ttacggtatt tttgattgtc 355321 gttaattctt cgaaagagtt tttgccctct gcttgaagat catagccagt gtggacgcag 355381 atgtagtcaa caccgagtgc gtcaatttct ttcgcacggg attcgatatc tttcacgtta 355441 atcatgtcca ctaagatttt cttcttttgt tttttggctt cttctactgc gcctttaatc 355501 gttgcatcgt ctgtagcccc taaaacggtg atgatgtcag cgcctgcttc cgacgctttc 355561 ataatttcgt agcctccggc atccatgatt ttcaggtctg caagaacctt caattgagga 355621 aatgcttctt ttatttcttt aacggctctt aggccttcat tgatgacgac cggtgttccg 355681 atttcaacta cgtcgatgta ttgttctacc tctttgacaa gctcaatggc ttccgggatg 355741 ttgacgaggt ctaatgcaag ctgtaattcc attgttgatc cactcccttt ttcgaattat 355801 tgttcattct ataggttcct tcttttgttg agaagtaggc actttgaagt caacaagtta 355861 cttggaggat actgtgagga gagacaatca gatttctttc gcttgatttt atgagtgagt 355921 ataatgaaaa aagagtctgc aaaaaagtaa gtaagtgatg atacgtatct aacatacaaa 355981 aaggttacta agggggggga ttctattgag ccggatggac gacaaaaggt ttaattgtga 356041 gaaggaatta acgcttgcag tgattggcgg taaatggaaa atgctcattt tatggcattt 356101 aggaaaagaa ggcacaaaac ggttcaatga attaaaaaca ttgattcctg atattacgca 356161 gaagatcctc gtgaatcagc tgagagagct tgagcaggat atgattgttc acagggaagt 356221 gtatccagtt gtcccgccga aggttgaata ttctctgacc ccgcacggag aaagcctcat 356281 gcctattctt gaagccatgt atgagtgggg gaaaggctat atggaattga ttgatatcga 356341 caaaaatgtc atgaaagaat cgttgtaaga cgctcttcgc aagggtgtct ttttttgcct 356401 ttttttcggt ttttgcgcgg tacacatagt catgtaaaga ttgtaaattg cattcagcaa 356461 taaaaaaaga ttgaacgcag cagtttggtt taaaaatttt tatttttctg taaataatgt 356521 ttagtggaaa tgattgcggc atcccgcaaa aaatattgct gtaaataaac tggaatcttt 356581 cggcatcccg catgaaactt ttcacccatt tttcggtgat aaaaacattt ttttcattta 356641 aactgaacgg tagaaagata aaaaatattg aaaacaatga ataaatagcc aaaattggtt 356701 tcttattagg gtggggtctt gcggtcttta tccgcttatg ttaaacgccg caatgctgac 356761 tgacggcagc ctgctttaat agcggccatc tgttttttga ttggaagcac tgctttttaa 356821 gtgtagtact ttgggctatt tcggctgtta gttcataaga attaaaagct gatatggata 356881 agaaagagaa aatgcgttgc acatgttcac tgcttataaa gattagggga ggtatgacaa 356941 tatggaaata actttttacc ctttaacgga tgcacaaaaa cgaatttggt acacagaaaa 357001 attttatcct cacacgagca tttcaaatct tgcggggatt ggtaagctgg tttcagctga 357061 tgcgattgat tatgtgcttg ttgagcaggc gattcaagag tttattcgca gaaatgacgc 357121 catgcgcctt cggttgcggc tagatgaaaa cggggagcct gttcaatata ttagcgagta 357181 tcggcctgtt gatataaaac atactgacac tactgaagat ccgaatgcga tagagtttat 357241 ttcacaatgg agccgggagg aaacgaagaa acctttgccg ctatacgatt gtgatttgtt 357301 ccgtttttcc ttgttcacca taaaggaaaa tgaagtgtgg ttttacgcaa atgttcatca 357361 cgtgatttct gatggtatct ccatgaatat tctcgggaat gcgatcatgc acatttattt 357421 agaattagcc agcggctcag agacaaaaga aggaatctcg cattcattta tcgatcatgt 357481 tttatctgaa caggaatatg ctcaatcgaa gcggtttgaa aaggacaagg cgttttggaa 357541 caaacaattt gaatcggtgc ctgaacttgt ttccttgaaa cggaatgcat ccgcaggggg 357601 aagtttagat gctgagaggt tctctaaaga tgtgcctgaa gcgcttcatc agcagattct 357661 gtcgttttgt gaggcgaata aagtcagtgt tctttcggta tttcaatcgc tgctcgccgc 357721 ctatttgtac agggtcagcg gccagaatga tgttgtgacg ggaacattta tgggcaaccg 357781 gacaaatgcg aaagagaagc agatgcttgg catgtttgtt tctacggttc cgcttcggac 357841 aaacattgac ggcgggcagg cgttttcaga atttgtcaaa gaccggatga aggatctgat 357901 gaagacactt cgccaccaaa agtatccgta taatctccta atcaacgatt tgcgtgaaac 357961 aaagagctct ctgaccaagc tgttcacggt ttctcttgaa tatcaagtga tgcagtggca 358021 gaaagaagag gatcttgcct ttttgactga gccgattttc agcggcagcg gattaaatga 358081 tgtctcaatt catgtaaagg atcgatggga tactgggaaa ctcaccatag attttgatta 358141 ccgcactgat ttattttcac gtgaagaaat caacatgatt tgtgagcgca tgattaccat 358201 gctggagaac gcgttaacgc atccagaaca tacaattgat gaattaacac tgatttctga 358261 tgcggagaaa gagaagctgc ttgcgagggc cggcggtaaa tctgtgagct accgtaagga 358321 catgacgata ccagagctgt tccaagaaaa ggctgaactg ctttctgatc atccagcggt 358381 tgtatttgaa gatcgcacat tgtcctatcg aacgttacat gagcaatctg cacgcatcgc 358441 caatgtgctg aaacagaaag gggttggccc ggacagtcct gtcgcggttt tgattgaacg 358501 ctctgaacgg atgattacag ctatcatggg aattttaaaa gccggcggag cctatgtgcc 358561 gattgatccg ggttttcctg ctgagcgcat tcaatatatt ttggaggact gcggggcgga 358621 tttcatcctg actgaatcga aggttgcggc gcctgaagcc gatgctgagc tgattgactt 358681 agatcaggcg attgaggaag gtgcagaaga aagcctgaat gcagatgtga acgctcggaa 358741 ccttgcctac attatttaca catcgggaac aaccggacgc ccgaaaggcg ttatgatcga 358801 gcatcgccag gttcatcatt tggttgaatc tctgcagcag acgatttatc aaagcggcag 358861 ccaaaccctg cggatggcat tgcttgcgcc gttccacttt gatgcgtcag tgaagcagat 358921 cttcgcgtcg cttcttttgg gccaaaccct ttatatcgta ccgaagaaaa cagtgacgaa 358981 cggggccgcc cttactgcat attatcggaa gaacagcatt gaggcgacgg acggaacacc 359041 ggctcatttg caaatgctgg cagcagcagg cgattttgaa ggcctaaaac tgaagcacat 359101 gctgatcgga ggagaaggcc tgtcatctgt tgttgcggac aagctgctga agctgtttaa 359161 agaagccggc acagcgccgc gtttgactaa tgtgtacggg ccgactgaaa cgtgcgttga 359221 cgcgtctgtt catccggtta tccctgagaa tgcagttcaa tcagcgtatg tgccgatcgg 359281 gaaagcgctg gggaataacc gcttatatat tttggatcaa aaaggccggc tgcagcctga 359341 aggcgtggcg ggtgagcttt atatcgcggg agacggtgtg ggccgaggct atttacattt 359401 gcctgaatta acggaagaga agtttttaca agatccattc gtgccgggcg atcgcatgta 359461 ccggaccggg gacgtggtgc gctggcttcc agatggaaca atcgaatatt taggcagaga 359521 ggatgaccag gtcaaagtcc gcggataccg gattgagctt ggggaaattg aagccgtgat 359581 tcagcaggcg ccagacgttg caaaagccgt tgttttggca cgccctgacg aacagggaaa 359641 tcttgaggtt tgcgcatatg ttgtgcagaa gcctggaagc gaatttgcgc cagccggttt 359701 gagggagcat gcggccagac agcttcctga ctatatggtg ccggcttact ttacagaagt 359761 gacagaaatt ccgcttacac caagcggcaa agtcgaccgc cgcaagctgt ttgcactaga 359821 ggtgaaggct gtcagcggca ctgcctatac agcgccgcga aatgagactg aaaaagcaat 359881 cgcagccatt tggcaggacg tgctgaacgt tgagaaggcg gggatctttg acaatttctt 359941 tgaaactggc ggacattcat taaaagccat gaccctttta acaaagattc ataaggaaac 360001 aggcattgag attccgcttc aatttttgtt tgagcatccg acgattacgg ctcttgcaga 360061 ggaagctgat cacagagaaa gcaaagcttt tgcggtgatt gaacctgctg aaaaacagga 360121 gcattacccg ctttcattgg cacagcagcg aacatatatc gtcagccagt tcgaggatgc 360181 gggagtcggc tataacatgc cagcagcagc aattctggaa gggcctttag atattcaaaa 360241 gctggagcgc gcatttcagg gattaatccg acgccacgag tcattgagaa catcatttgt 360301 tcttgaaaac agcacgccga gacagaaaat tcacgatagc gttgatttca acatcgaaat 360361 gattgaaaga ggcggccgct cagatgaggc aattatggct tcattcgttc ggacatttga 360421 tttggcgaaa gctccgctgt tcagaatcgg tttgctgggg cttgaagaga accgtcatat 360481 gctgctgttt gacatgcacc atttgatttc tgacggtgta tccattggca ttatgctgga 360541 ggagttagca cgcatttata aaggcgaaca gcttcctgat cttcgtctcc agtataagga 360601 ctacgctgta tggcaaagca gacaggctgc tgaagggtac aagaaggacc aggcttattg 360661 gaaggaagtc tttgcaggcg agctcccggt gcttcagctt ctgtccgatt acccaagacc 360721 acctgttcaa agctttgaag gggatcgggt gtcaatcaag ctggatgcgg gggtaaagga 360781 tcgcctcaat cgtttggctg aacaaaacgg cgccacttta tatatggtga tgctttccgc 360841 ttactatacg cttttgtcaa agtatacggg gcaggatgac atcattgtcg ggacaccgtc 360901 agcgggcaga aatcactccg atacagaggg cattatcggg atgttcgtca atacgcttgc 360961 gattcgcagt gaggtgaagc agaatgagac gtttacccaa ttgatctcgc gtgtccgcaa 361021 acgggtgctg gatgcctttt ctcatcagga ctatccgttt gagtggcttg ttgaagattt 361081 gaacatcccg cgtgatgtta gcaggcatcc gctgtttgac acgatgttca gccttcaaaa 361141 cgcgacagag ggcattccgg ctgtcggcga tctttccttg tctgttcaag agaccaattt 361201 caagattgcc aaatttgatt tgacggtgca ggcgagagaa accgatgaag gcattgagat 361261 tgatgtggat tacagcacaa agctgtttaa acaaagcacg gcagacaggc tgcttacgca 361321 ttttgcgcgt ttgcttgaag atgctgcggc tgatccagag aagccgattt ctgagtataa 361381 gcttctttct gaagaggagg ctgcttcgca aattcagcag tttaacccgg gcagaacacc 361441 ttatccgaaa gataaaacaa ttgttcagct gtttgaggag caagcggcga atacgccaga 361501 ccacactgcg cttcaatatg aaggcgaatc actcacttat cgtgaactga atgaacgggc 361561 caatcgttta gcccgcggca ttctttctct tggagctggc gaaggcagaa ctgcggctgt 361621 cttatgcgag cggtcaatgg atatgattgt gtcgatcttg gcagtattaa aatcaggttc 361681 ggcttatgtt ccgatcgatc cggaacatcc gattcagcgg atgcagcatt tcttccgtga 361741 cagcggagca aaggtgcttc tcactcagag gaaattaaag gctttggcgg aagaagcgga 361801 atttaagggc gttatcgtgc tagccgatga ggaagaaagc tatcatgccg atgcgcgaaa 361861 tctcgcactg cctcttgatt ctgcagcaat ggccaacctg acgtatactt ccggaacgac 361921 tggaacacct aaggggaata tcgtgacaca tgccaatatt ctccgcacgg tgaaggaaac 361981 gaattatctc agcattacag aacaggatac gattctcggt ctttccaatt acgtgtttga 362041 cgcgtttatg ttcgatatgt tcggctcttt gttaaacgga gccaagctgg tgctgatacc 362101 gaaggaaacc gttttggaca tggctcgcct gtcccgcgtc attgaacggg agaacatcag 362161 cattctcatg attacaaccg ctttgttcca cttgcttgtg gacttgaatc cggcatgctt 362221 gtcaacgctt cgcaagatta tgtttggcgg ggaacgggct tcggttgagc atgtcagaaa 362281 agctttgcaa acggttggaa agggcaagct ccttcatatg tatggaccgt ctgaaagcac 362341 ggttttcgcg acgtatcatc cggttgatga attggaggag cacacgctgt ctgttccgat 362401 tggaaaaccg gtcagcaata cggaagtata cattcttgac cgtacgggac acgtgcagcc 362461 tgccgggatt gccggagagc tttgcgtcag cggcgaagga ctcgtgaaag gctattacaa 362521 ccgtccagaa ctgactgagg agaaatttgt tccccatccg tttacatccg gcgaacgcat 362581 gtataaaacg ggagaccttg cgagatggct gccgaatggc gacatcgaat ttatcgggcg 362641 aatcgaccat caggtgaaga ttcgcggaca gcgcatcgag cttggagaaa tcgaacatca 362701 gctgcaaacc catgatcgtg ttcaggaaag tgttgtgctt gccgttgatc aaggagcggg 362761 agataaactg ttgtgtgctt actatgtcgg agaaggagac atctcatcac aagagatgag 362821 agagcatgct gcgaaggact tgccggcata tatggttcct gcggtgttta tccaaatgga 362881 cgagctgccg ctgacaggga acggaaaaat tgaccggaga gcgctgccga ttcctgatgc 362941 caacgtttca agaggtgttt catatgttgc gccacgcaat ggaacggaac aaaaagtcgc 363001 ggacatttgg gcacaggtac ttcaggcaga acaagtcggc gcttatgacc acttctttga 363061 cattggcgga cattcattag caggcatgaa gatgcttgcc ttggttcatc aggaactggg 363121 cgttgagctg tcactcaagg atctcttcca gtcaccgacg gttgagggct tggcacaggt 363181 gattgcctct gctgaaaaag ggacagccgc aagtatcagc ccggcagaga aacaagatac 363241 gtatcctgtt tcttcaccgc aaaaacggat gtacgtgctt cagcagcttg aggatgcgca 363301 aacgagctat aacatgccgg cggttctgcg cctgacaggt gagcttgatg ttgaaaggct 363361 taacagcgtc atgcagcagt taatgcagcg tcatgaagcc ttgagaacca cgtttgaaat 363421 aaaagatgga gaaacggtgc agcggatctg ggaagaggct gagtgcgaga tagcctattt 363481 cgaagccccg gaagaagaga cagagcggat cgtttctgag tttattaagc ctttcaaaat 363541 cgaccaactt ccactgttca gaatagggct tatcaagcat tcagacactg agcatgtgct 363601 gctgttcgat atgcatcata ttatttctga tggtgcatct gtcggtgtgc tgattgagga 363661 gctttcaaag ctgtacgacg gagaaaccct tgagccgctc cgtattcaat ataaggatta 363721 tgccgtgtgg cagcagcagt tcattcagtc tgagctttac aagaagcaag aagagcattg 363781 gctgaaggag ctggacggag agctgccggt gctgacgctt ccgactgatt acagtcggcc 363841 tgccgttcaa acatttgagg gagaccgcat tgcattttca ttagaagcag gcaaagctga 363901 tgctctgcgc aggcttgcaa aagaaacgga ttccacgctt tacatggtgc ttctggcttc 363961 atacagtgcg tttttatcaa aaattagcgg gcaagacgat atcatcgtcg gttcacctgt 364021 ggccggacga tctcaagcgg acgtcagccg cgtcatcgga atgttcgtca atacattggc 364081 gctgcgcacg tatccgaagg gtgaaaagac gtttgctgac tatcttaacg aagtgaaaga 364141 aacggcactc agcgcttttg atgcgcagga ttacccactt gaggatttga tcggaaatgt 364201 tcaggttcag cgtgacacaa gcagaaatcc gttattcgat gcagtttttt caatgcaaaa 364261 tgcgaatata aaggatttaa caatgaaagg gattcagctt gagccgcatc cgtttgaacg 364321 gaaaacagcc aagtttgacc tcacgctgac ggctgacgaa accgacggag ggcttacatt 364381 cgtactcgaa tacaatacag ctctgtttaa gcaggaaacg attgaacgat ggaagcaata 364441 ttggatggag cttttagatg cagttactgg gaacccgaac cagccgcttt ccagcctgtc 364501 actggtcacc gagacagaaa agcaagcgct tcttgaggca tggaagggca aagcgctgcc 364561 tgtgccgaca gacaaaacgg ttcatcagct attcgaagag actgcccagc gccacaaaga 364621 ccgcccggct gtcacataca acggccagtc ttggacgtac ggcgagctga atgcgaaggc 364681 aaaccgtctc gcgcggattc tgatggactg cggcatcagc ccggatgacc gcgtcggcgt 364741 tctcacgaag ccgtcgcttg aaatgtccgc cgcggtgctc ggcgtcttga aagccggagc 364801 ggcgtttgtg ccgattgatc ctgactatcc ggatcagcgg attgagtata ttttacagga 364861 cagcggcgcg aagcttctct tgaaacagga aggcatttca gtgccggaca gctatacggg 364921 agatgtcatt cttctcgacg gaagccgcac gattctaagc ctgccgcttg atgaaaacga 364981 cgaggaaaat ccagaaaccg ctgtaaccgc ggagaacttg gcgtacatga tttacacgtc 365041 tggaacgacc ggacagccga agggtgtcat ggtcgagcac catgcgcttg tgaacctgtg 365101 cttctggcac cacgacgcgt tcagcatgac agcggaggac cgcagtgcga agtacgcggg 365161 ctttgggttc gacgcttcca tttgggagat gttcccgacc tggacgatcg gtgccgaact 365221 tcacgtcatt gaggaagcga tccgcctcga tatcgtccgc ctgaacgatt attttgaaac 365281 gaacggcgta acgatcacgt tcctgccgac acagcttgcg gaacagttca tggagcttga 365341 gaacacatca cttcgcgtat tgcttactgg aggagacaag ctgaagcgcg cagtgaaaaa 365401 gccgtacaca ctcgtcaata actacgggcc gacagagaat acggtcgttg ccacaagcgc 365461 agaaatccat ccggaggaag gctcgctttc catcggaagg gccattgcca atacgagagt 365521 atacattctc ggcgagggca atcaggtgca gccggaaggc gtagccggag agctttgcgt 365581 ggcggggcgc ggactggcac gcggctatct gaatcgagaa gacgaaaccg cgaagcggtt 365641 tgtcgctgat ccgtttgtgc cgggtgagcg catgtaccgc accggcgatt tggtgaaatg 365701 gacgggcggc ggcatcgaat acatcggccg gatcgaccag caggtcaagg tccgcggcta 365761 ccggatcgag ctctcagaaa ttgaagtcca gctcgcccag ctttctgagg tgcaggatgc 365821 ggcggtgaca gctgtcaaag ataaaggcgg caacacagcg atcgcggcgt atgtcacacc 365881 ggaatcagct gacatagaag cactgaaatc agcactgaag gaaaccctgc cggattacat 365941 gatcccggcg ttctgggtga cgctgaacga gcttccggtt acggcaaacg gcaaagtgga 366001 ccgcaaagcc ttgcctgagc cggacatcga agcgggaagc ggagaataca aagcgccgac 366061 gaccgacatg gaagagctgc ttgccggcat ctggcaggac gtgcttggaa tgtctgaagt 366121 cggtgtcacc gacaatttct tctcgcttgg cggagattcc atcaaaggaa ttcaaatggc 366181 gagccgcttg aaccagcacg gctggaagct ggaaatgaaa gatctcttcc agcacccgac 366241 gatcgaagag ctcacccagt acgtagagcg tgccgaaggc aaacaggcag accaaggccc 366301 ggtggagggc gaagtcatcc tgacgccgat ccagcgctgg ttctttgaaa agaacttcac 366361 gaacaagcac cactggaacc aatctgtgat gcttcacgcc aagaagggct ttgatcctga 366421 acgggtggag aaaacattgc aggcgctgat cgagcatcat gacgcgctcc gcatggtcta 366481 tcgtgaggga caggaagacg tcattcaata caacagaggt cttgaagctg cttcagctca 366541 attggaggtc atccagattg agggccaagc tgcagattac gaagaccgaa tagagagaga 366601 agcggagcgt ttgcaaagca gcatcgactt gcaggaaggc ggcttgttaa aagcaggctt 366661 gttccaagcg gaagacggag atcacttgct tcttgccatt caccacttag tggttgacgg 366721 cgtgtcgtgg cggattttac tggaggattt cgccgcggta tatacacagc ttgagcaagg 366781 caatgaaccg gttctcccgc agaaaacaca ttcatttgca gagtatgcag agagattgca 366841 agacttcgcg aactccaaag cctttttgaa agaaaaagag tattggagac agcttgaaga 366901 acaagctgtt gcggcaaagc ttccgaaaga ccgcgaatct ggtgatcagc gaatgaaaca 366961 tacaaagaca attgaattct cgctgactgc tgaagagaca gaacagctca ccacaaaggt 367021 gcatgaggca tatcacacag aaatgaatga tattttgctg acggcattcg gattggcaat 367081 gaaggagtgg acgggtcaag atcgagtaag tgttcattta gaggggcatg gacgtgaaga 367141 aatcatagaa gacctgacca tttctcgcac agtcggctgg tttacaagta tgtacccaat 367201 ggtgctcgat atgaagcatg cggatgatct gggctaccag ctgaagcaaa tgaaagaaga 367261 tatcagacat gtgccgaata agggagtcgg atacggcatt ctgcgctatc tgacggcacc 367321 ggaacataaa gaagatgtgg cgttctcgat tcagccggat gtcagcttca actatttagg 367381 tcagtttgac gaaatgtcgg atgcaggttt gtttacgaga tcagagctgc catcaggaca 367441 gtcattaagc cctgaaacag aaaaaccgaa tgcgctggat gttgtcggat atatcgaaaa 367501 cggaaaactg acgatgtcac tggcctatca ttctcttgaa tttcatgaaa aaacagtaca 367561 aacattcagt gacagcttta aagcgcatct tctcagaatc attgaacatt gcctatctca 367621 agatggtacg gaactgaccc cgagtgatct tggtgacgac gatttgacgc tggatgagct 367681 ggataaatta atggaaattt tctaatagag gtggcatatg agcaaaaaat cgattcaaaa 367741 ggtgtacgca ctgacaccaa tgcaggaggg aatgctgtat catgcgatgc ttgatccgca 367801 ttcttcctcg tacttcacac aattagagct tgggattcac ggcgcttttg atcttgaaat 367861 ctttgagaaa agcgtcaatg aactgattcg gtcatacgat attctccgta cggtatttgt 367921 gcatcagcag ctgcaaaaac cgcgtcaggt cgtgttagcg gaacgcaaaa caaaagtgca 367981 ttatgaggat atcagtcatg cagacgaaaa ccgccagaaa gagcacattg agcgttacaa 368041 acaagacgtt cagcgccaag gctttaacct ggcaaaagac atattgttca aggtagcggt 368101 tttccgcctt gctgcagatc agctgtatct tgtctggagc aatcatcata ttatgatgga 368161 cggctggagc atgggcgtcc tcatgaaaag cctgttccaa aactatgaag cgctcagagc 368221 aggcaggaca ccggcaaacg gtcagggcaa gccttattcc gattacatca agtggcttgg 368281 aaaacaggac aatgaagaag cggagagcta ctggagcgag cgcttggcgg gttttgaaca 368341 gccaagcgtg ctcccgggcc gcctgcctgt gaaaaaagac gaatacgtca ataaagaata 368401 ttcatttaca tgggacgaaa cactggttgc ccgtattcag caaaccgcaa atctccatca 368461 agtgacaggg cctaacctat ttcaggccgt ttggggcatt gttctcagca aatacaactt 368521 tacggatgat gtgatcttcg gaacggtcgt ctcgggacga ccgtctgaaa tcaacggaat 368581 cgaaacgatg gcggggctgt ttatcaacac cattccagtg cgggtgaaag ttgaacgaga 368641 tgctgcattc gctgatattt tcacagctgt tcagcagcat gcagtagagg cagagcgtta 368701 cgattacgtg ccgctctatg agattcaaaa acgctcagct cttgatggca atctcttaaa 368761 ccatctggtc gcgtttgaaa attatccgct tgatcaagag cttgaaaacg gcagcatgga 368821 agaccgcctc gggttttcga ttaaggtaga aagcgcattt gaacaaacga gcttcgattt 368881 caacctgatt gtgtatccgg gcaaaacgtg gaccgtcaaa attaaatata acggagccgc 368941 ctttgattcc gcttttatcg aacggacagc ggagcacctt acccgcatga tggaagcagc 369001 tgtcgatcag ccggccgctt ttgtgcgtga gtacgggctt gtgggagacg aagagcagcg 369061 gcaaattgtc gaggtgttta acagcacgaa agccgaactc cctgaaggaa tggctgttca 369121 ccaagtgttt gaagagcaag cgaaacggac gccggcgagc accgccgtcg tatatgaagg 369181 aaccaagctg acgtaccgcg agctgaatgc agcggctaac cgtctggcga gaaagcttgt 369241 cgaacatggg cttcaaaaag gggaaacagc agcgattatg aacgaccgct cagtagaaac 369301 cgttgtcggc atgctggctg ttttaaaagc aggcgccgca tatgtgccgc ttgatccagc 369361 gcttcctggg gatcgtcttc gtttcatggc agaggacagc tccgttcgaa tggttttgat 369421 cggaaattct tatacagggc aggcacatca gctgcaagtg ccggttctta cactggacat 369481 aggctttgaa gagagtgaag cggctgacaa tctcaacctg ccatccgccc cgtctgattt 369541 ggcgtacatc atgtacacat ccggttcaac gggcaaaccg aaaggcgtca tgatcgaaca 369601 taaaagcatt ctgcgcctcg tcaaaaatgc cgggtacgtt cctgttactg aagaagaccg 369661 catggcgcaa acgggagctg tcagctttga tgccggaacg tttgaggtat tcggcgcact 369721 gctgaatggc gcagcacttt atccggtcaa aaaagagaca ctgcttgatg cgaaacaatt 369781 tgctgcattc ctgcgtgagc aaagcatcac aactatgtgg ctgacatcac ctttattcaa 369841 ccagcttgct gcaaaggatg cgggtatgtt cggcacactg cgccatttaa tcatcggcgg 369901 agatgccctt gtcccgcata ttgtcagcaa agtaaaacag gcatcgccgt cgctttcatt 369961 gtggaacgga tacggcccga cagaaaacac gacgttttca accagttttc tgatcgaccg 370021 cgagtatggc ggctctatcc caatcgggaa gccgatcgga aattccactg cctatattat 370081 ggatgagcag caatgcctgc agccaatcgg cgcgcctggt gagctttgcg taggcggaat 370141 cggtgtagcg cgtgggtatg tcaatctccc tgagctgacg gagaagcaat ttctggaaga 370201 cccgttcaga ccgggtgaga gaatttaccg cactggtgac ttggcaagat ggctgccgga 370261 cggcaatatc gaatttttag gcagaatcga caaccaagtg aaggtgcgcg gcttccgaat 370321 tgagcttggc gaaattgaaa caaaactgaa catggctgag catgtgacag aagccgcggt 370381 gatcatacgc aagaacaaag cagacgaaaa tgaaatttgc gcgtacttca cggcggatcg 370441 tgaagtggct gtgagtgagc tgagaaaaac actgtctcag tctttgcctg actatatggt 370501 ccctgcccac ctgattcaaa tggacagcct gccgctcacg ccaaacggga aaatcaacaa 370561 aaaggaactg cctgcaccgc aatcagaagc cgtgcagccg gaatacgcag caccaaaaac 370621 agagagtgaa aagaaattag cggagatctg ggaaggaata ctcggcgtca aagcaggcgt 370681 taccgataac ttctttatga tcggcggcca ttctttgaaa gcgatgatga tgacggcgaa 370741 aattcaagag cattttcata aggaagttcc gataaaagtg ctttttgaaa agccgactat 370801 tcaagaactg gcactgtatt tggaagagaa cgaaagcaag gaggagcaga cgtttgaacc 370861 gatcaggcaa gcatcttatc agcagcatta tcctgtatcc ccggcccagc ggagaatgta 370921 tatcctcaat cagcttggac aagcaaacac aagctacaac gtccccgctg tacttctgct 370981 ggagggagaa gtagataaag accggcttga aaacgcgatt cagcaattaa tcaaccggca 371041 cgaaatcctc cgtacatcgt ttgacatgat cgacggagag gttgtgcaaa ccgttcataa 371101 aaacatatcg ttccagctgg aggctgccaa gggacgggaa gaagacgcgg aagagataat 371161 caaagcattt gttcagccgt ttgaattaaa ccgcgcgccg ctcgtccgtt cgaagcttgt 371221 ccagctggaa gaaaaacgcc acctgctgct cattgatatg catcatatta ttactgacgg 371281 aagttcaaca ggcattctaa tcggtgatct tgccaaaata tatcaaggcg cagatctgga 371341 actgccacaa attcactata aagattacgc agtttggcac aaagaacaaa ctaattatca 371401 aaaagatgag gaatactggc tcgatgtctt taaaggcgaa ctgccaatac tggatcttcc 371461 cgcggatttc gagcggccag ctgaacggag ctttgcggga gagcgcgtga tgtttgggct 371521 tgataagcaa atcacggctc aaatcaaatc gctcatggca gaaacagata cgacaatgta 371581 catgtttttg ctggcggcgt tcaatgtact cctttccaag tacgcgtcac aggatgatat 371641 cattgtcggc tcgccgacag ctggcagaac acatcctgat ctgcaaggtg tgccgggtat 371701 gtttgtcaac acggtggcac tcagaacggc accagcggga gataaaacct tcgcgcaatt 371761 ccttgaagag gtcaaaacag ccagccttca agcattcgag caccagagct atccgcttga 371821 ggagctgatt gaaaagcttc cgcttacaag ggatacaagc agaagtccgc tgttcagcgt 371881 gatgttcaac atgcagaata tggagattcc ttcattaaga ttaggagatt tgaagatttc 371941 ctcgtattcc atgcttcatc atgttgcgaa atttgatctt tccttggaag cggtcgagcg 372001 tgaagaggat atcggcctaa gctttgacta tgcgactgcc ttgtttaagg acgagacgat 372061 ccgccgctgg agccgccact ttgtcaatat catcaaagcg gccgcggcta atccgaacgt 372121 tcggctgtct gatgtagatc tgctttcatc tgcagaaacg gctgctttgc tagaagaaag 372181 acatatgact caaattaccg aagcaacctt tgcagcactt tttgaaaaac aggcccagca 372241 aacacctgac cattctgcgg tgaaggctgg cggaaatctg ttgacctatc gcgagcttga 372301 tgaacaggcg aaccagctgg cgcatcatct tcgtgcccaa ggggcaggaa atgaagacat 372361 cgtcgcgatt gttatggacc ggtcagctga agtcatggta tccattctcg gtgtcatgaa 372421 ggcgggggca gctttccttc cgattgatcc tgatacacct gaagaacgaa tccgttattc 372481 attagaggac agcggagcaa aatttgcggt cgtgaatgaa agaaacatga cggctattgg 372541 gcaatatgaa gggataattg tcagccttga tgacggtaaa tggagaaatg aaagcaagga 372601 gcgcccatca tccatttccg ggtctcgcaa tcttgcatac gtcatttata cgtccggtac 372661 gaccggaaag ccaaagggcg tgcagattga gcatcgtaat ctgacaaact atgtctcttg 372721 gtttagtgaa gaggcgggcc tgacggaaaa tgataagact gtattgcttt catcttacgc 372781 atttgacctt ggctatacga gcatgttccc tgtacttctg ggcgggggcg agctccatat 372841 cgtccagaag gaaacctata cggcgccgga tgaaatagcg cactatatca aggagcatgg 372901 gatcacttat atcaagctga caccgtctct gttccataca atagtgaaca ccgccagttt 372961 tgcaaaagat gcgaactttg aatccttgcg cttgatcgtc ttgggaggag aaaaaatcat 373021 cccgactgat gttatcgcct tccgtaagat gtatggacat accgaattta tcaatcacta 373081 cggcccgaca gaagcaacga tcggcgccat cgccgggcgg gttgatctgt atgagccgga 373141 tgcatttgcg aaacgcccga caatcggacg cccgattgcg aatgccggtg cgcttgtctt 373201 aaatgaagca ttgaagcttg tgccgcctgg agcgagcgga cagctctata tcacgggaca 373261 ggggctcgcg agagggtatc tcaacaggcc tcagctgaca gccgagagat ttgtagaaaa 373321 tccatattcg ccgggaagcc tcatgtacaa aaccggagat gtcgtacgaa gactttctga 373381 cggtacgctt gcatttatcg gccgggctga tgatcaggtg aaaatccgag gctaccgcat 373441 tgagccgaaa gaaattgaaa cggtcatgct cagcctcagc ggaattcaag aagcggttgt 373501 actagcggtt tccgagggcg gtcttcaaga gctttgcgcg tattatacgt cggatcaaga 373561 tattgaaaaa gcagagctcc ggtaccagct ttccctaaca ctgccgtctc atatgattcc 373621 tgctttcttt gtgcaggttg acgcgattcc gctgacggca aacggaaaaa ccgacagaaa 373681 cgctctgccg aagcctaacg cggcacaatc cggaggcaag gccttggccg caccggagac 373741 agcgcttgaa gaaagtttat gccgcatttg gcagaaaacg cttggcatag aagccatcgg 373801 cattgatgac aattttttcg atttaggcgg ccattcatta aaagggatga tgctgattgc 373861 caacattcag gcggaattgg agaaaagcgt accgcttaaa gcactgttcg agcagccgac 373921 agttcgccag ctggcggctt atatggaggc gtctgctgtt tcaggcggcc atcaagtact 373981 caaaccggct gacaagcagg atatgtatcc attgtcatcc gcacagaaac gaatgtacgt 374041 gctcaatcag cttgaccgcc agacgataag ctacaacatg ccatctgttc ttctaatgga 374101 aggagagctt gatatttcgc gcctgcgcga ctcactcaat cagcttgtga accgtcacga 374161 atcattgcgg acgtcattta tggaagctaa tggtgagcct gttcagcgca tcattgagaa 374221 ggcggaggtt gatcttcatg tgtttgaagc caaagaagac gaagcggacc aaaagattaa 374281 ggaatttatc cggccattcg acttaaacga cgcaccgctc attcgcgcag ctttgcttcg 374341 aatagaagcg aaaaaacatt tgctgctttt agatatgcat catatcatcg cagacggcgt 374401 ctcaagaggc atctttgtaa aagaattggc gctgctttac aaaggagagc agcttccgga 374461 gccgacgctt cattataaag atttcgccgt ttggcaaaat gaagctgagc aaaaagaacg 374521 gatgaaggag catgaggcgt actggatgtc agttctttca ggcgagctgc cagagcttga 374581 tctcccgctc gattatgccc gtccgcctgt gcaaagcttt aaaggagata cgatccgttt 374641 ccgtacggga agtgagacgg caaaggcggt agaaaaactg cttgccgaaa ccggaacgac 374701 cttgcacatg gtgctccatg ctgttttcca cgtcttttta agcaaaattt ccggacagcg 374761 ggatatcgtc atcggctccg ttactgccgg ccggacgaat gctgatgttc aggacatgcc 374821 gggaatgttc gtcaatacac ttgccctgag aatggaagcg aaagaacagc aaacatttgc 374881 ggagcttttg gagctagcaa agcagacgaa cctgtcagcc cttgagcatc aggagtatcc 374941 gtttgaagat ctggttaatc agcttgatct ccctcgggat atgagccgaa acccattgtt 375001 taatgtgatg gtgacgacag aaaaccctga taaagaacag cttacattgc aaaatctgag 375061 catttcacct tatgaggctc atcagggaac ttctaagttt gatctgacac tgggcggatt 375121 tactgatgaa aatggcattg gcttgcagct cgaatatgcg acagatctgt tcgcaaaaga 375181 aacagctgaa aaatggagcg aatacgttct gcggctacta aaggctgttg cggataaccc 375241 gaaccagccg ctttccagtc tgttactggt caccgagaca gaaaagcaag cgcttcttga 375301 ggcatggaag ggcaaagcgc tgcctgtgcc gacagacaaa acggttcatc agctattcga 375361 agagactgtc cagcgccaca aagaccgccc ggctgtcaca tacaacggcc aatcttggac 375421 gtacggcgag ctgaacgcga aggcaaaccg cctcgcccgg attctgatgg actgcggcat 375481 cagcccggat gaccgcgtcg gcgttctcac gaagccgtcg cttgaaatgt ccgccgcggt 375541 gctcggcgtc ttgaaagccg gagcggcgtt tgtgccgatt gatcctgact acccggatca 375601 gcggattgag tatattttac aggacagcgg cgcgaagctt ctcttgaaac aggaaggcat 375661 ttcagtgccg gacagctata cgggagatgt cattcttctc gacggaagcc gcacgattct 375721 aagcctgccg cttgatgaaa acgacgaggg aaatccagaa accgctgtaa ccgcggagaa 375781 cttggcgtac atgatttaca cgtctggaac gaccggacag ccgaagggtg tcatggtcga 375841 gcaccatgcg cttgtgaacc tgtgcttctg gcaccacgac gcgttcagca tgacagcgga 375901 ggaccgcagt gcgaagtacg cgggcttcgg gttcgacgct tccatttggg agatgttccc 375961 gacctggacg atcggcgctg aacttcacgt cattgatgaa gcgatccgcc tcgatatcgt 376021 ccgcctgaac gattattttg aaacgaacgg cgtaacgatc acgttcctgc cgacacagct 376081 tgcggaacag ttcatggagc ttgagaacac atcacttcgc gtcctcttga ccggaggaga 376141 caagctgaag cgggcagtga aaaagccgta cacactcgtc aacaactacg ggccgacaga 376201 aaatacggtc gttgccacaa gcgcagaaat ccatccggag gaaggctcgc tttccatcgg 376261 acgggccatt gccaatacga gagtatacat tctcggcgag ggcaatcagg tgcagccgga 376321 aggcgtagcc ggagagcttt gcgtggcggg gcgcggactg gcacgaggct atctgaatcg 376381 agaagacgaa accgcgaagc ggtttgtcgc tgatccgttt gtgccgggtg aacgcatgta 376441 ccgcaccggc gacttggtga agtgggtgaa cggcggcatc gaatacatcg gccggatcga 376501 ccagcaggtc aaggtccgcg gctaccggat cgagctctca gaaattgaag tccagctcgc 376561 ccagctttct gaggtgcagg atgcggcggt gacagctgtc aaagataaag gcggcaatac 376621 agcgatcgcg gcgtatgtca caccggaaac agctgacata gaagcactaa aatcaacact 376681 aaaggaaacc ctgccggatt acatgatccc ggcgttctgg gtgacgctga acgagcttcc 376741 ggttacggca aacggcaaag tcgaccgcaa agccttgcct gagccggaca tcgaagcggg 376801 aagcggagaa tacaaagcgc cgacgaccga catggaagag ctgcttgccg gcatctggca 376861 ggacgtgctt ggaatgtctg aagtcggtgt caccgacaat ttcttctcgc ttggcggaga 376921 ttccatcaaa ggaattcaaa tggcgagccg cttgaatcag cacggctgga agctggaaat 376981 gaaagatctc ttccagcatc cgacgatcga agagctcacc cagtacgtag agcgtgccga 377041 aggcaaacag gcagaccaag gcccggtgga gggcgaagtc atcctgacgc cgatccagcg 377101 ctggttcttt gaaaagaact tcacgaacaa gcaccactgg aaccaatcgg tgatgcttca 377161 cgccaaaaag ggctttgatc ctgaacgggt ggagaaaaca ttgcaggcgc tgatcgagca 377221 tcatgacgcg ctccgcatgg tctaccgcga ggaaaacggg gacatcgttc aggtgtataa 377281 accgatcggt gagagcaagg tcagcttcga aatcgtggat ctgtacggct ccgatgaaga 377341 gatgctgaga agccagatta agcttctcgc gaacaagctg caaagcagtc tcgatctgcg 377401 aaacgggccg cttttaaagg cggagcaata tcgcacagaa gctggggatc acctgctcat 377461 tgctgtacac catctcgtgg tcgacggtgt gtcatggcgg attttgcttg aagactttgc 377521 ttcaggctac atgcaggctg agaaagaaga gagccttgtc ttcccgcaaa aaacaaactc 377581 cttcaaggat tgggcggaag aactggcggc attcagccaa tcagcgcatc ttttacagca 377641 ggctgaatac tggtcgcaaa ttgccgctga acaggtttct cctttaccta aggattgtga 377701 aacagagcag cggatcgtca aggatacatc atctgtccta tgtgaattaa cggcagaaga 377761 cactaagcat cttttaacag atgttcatca gccatatgga actgaaatca acgatattct 377821 tctcagcgcg ctcggtttga caatgaaaga atggacaaag ggggccaaaa ttggcattaa 377881 ccttgaggga cacggccggg aggacattat cccgaatgtg aatatctcca gaacggtcgg 377941 ctggtttacg gcacaatacc ctgttgtgct cgacatatct gacgcagatg cctcagctgt 378001 gatcaaaaca gtcaaagaaa acctgcgccg cattccggac aaaggtgttg gctacggcat 378061 tcttcgttat ttcacagaaa cagcggaaac aaagggcttc acaccggaga tcagcttcaa 378121 ctatttgggc caattcgaca gtgaagtcaa aaccgatttc tttgaaccgt ccgctttcga 378181 tatggggcgc caagtaagcg gagaatcaga ggcgctgtac gcattaagct tcagcggcat 378241 gatcagaaac ggccggtttg tgctttcctg ctcctacaat gagaaggagt ttgaaagagc 378301 tacagtcgag gagcaaatgg aacggtttaa agaaaacctc ctgatgctaa tccgccattg 378361 cacggaaaaa gaagacaagg aattcacacc aagcgacttc agcgccgaag accttgaaat 378421 ggacgagatg ggagatatct ttgacatgct tgaggagaat ttaaaataaa acgcaaggga 378481 attacagaag gcgggagcga aacatatgag tcaatttagc aaggatcagg ttcaagatat 378541 gtattaccta tcgccgatgc aggaagggat gctttttcat gccatcctga atcccggcca 378601 aagcttttac cttgaacaaa tcacgatgaa agtaaaaggc agcttgaata tcaaatgtct 378661 tgaagaaagc atgaatgtga tcatggaccg gtacgatgta tttcgtaccg tgttcattca 378721 cgaaaaagta aaaaggcctg tccaagtcgt attgaaaaaa cggcagttcc atatagaaga 378781 aatcgatctg acacacttaa cgggcagcga gcaaacagcc aaaatcaatg agtacaaaga 378841 acaggataag atcaggggtt ttgatttgac gcgggatatt ccgatgcggg cagccatttt 378901 caagaaagct gaagaaagct ttgaatgggt gtggagctac caccacatta ttttggacgg 378961 atggtgcttc ggcatcgtcg tacaggatct atttaaggta tacaatgctc tgcgcgaaca 379021 aaagccgtac agcctgccgc ccgtcaaacc gtataaagac tacatcaagt ggcttgaaaa 379081 gcaggataaa caagcatcac tgcgttactg gcgcgaatat ttagagggct ttgaaggaca 379141 aacgacgttt gcggagcaaa gaaagaaaca aaaggacggc tatgagccga aagagctgct 379201 cttttcactg tcggaggcgg aaacaaaggc ctttaccgag cttgcaaaat cgcagcatac 379261 cactttgagt acggcgctgc aggcagtctg gagcgtattg atcagccgct atcagcagtc 379321 tggcgatttg gccttcggta cagttgtttc agggcgtccc gcggaaatca aaggcgttga 379381 acatatggtc gggctgttta tcaacgttgt cccgagacgt gtgaagctgt ctgagggtat 379441 cacatttaac ggcttgctca agcggctgca ggagcaatcg ctgcagtccg agccgcatca 379501 atatgtgccg ctttatgaca tccaaagcca ggccgatcag ccgaaactga ttgaccacat 379561 cattgttttt gagaactatc cgcttcagga tgcgaaaaat gaagaaagca gtgaaaacgg 379621 ctttgatatg gtggatgttc atgtttttga gaagtcgaat tatgatctca acctgatggc 379681 ttccccggga gatgagatgc tgattaagct tgcctataat gagaatgtgt ttgatgaggc 379741 gtttatcctg cgcttgaaat ctcagcttct tacagcaatt cagcagctca tccagaatcc 379801 tgatcagcct gtcagcacga tcaacctcgt tgacgacagg gagagagaat ttttgctaac 379861 cggcttaaac ccgccggctc aagctcatga aacaaagcct ctgacgtatt ggttcaagga 379921 agcagtgaac gccaatccgg atgcaccggc gcttacgtat tccggccaga ccctgtctta 379981 tcgcgaatta gatgaggaag cgaaccgcat tgcacgccgg ctgcaaaaac acggtgcggg 380041 caaaggctct gttgtagcgc tgtacacgaa gcgctcactt gaactggtga tcggcattct 380101 cggtgtatta aaggcgggag cagcctatct gccggttgat ccgaagctgc cagaggaccg 380161 aatctcgtat atgctggctg acagtgcggc agcctgtctt ctgacgcatc aggagatgaa 380221 agaacaagcg gctgagctgc cgtatacagg cacaacgctc ttcattgatg atcaaacacg 380281 gtttgaagaa caggcaagcg atcctgcaac cgcgattgat cctaatgatc cggcatatat 380341 catgtacacg tccggcacaa ccggaaagcc aaagggcaat atcaccactc atgccaatat 380401 tcaaggattg gtcaagcatg tagactacat ggcattttct gatcaggata cgttcttgtc 380461 tgtttcgaat tacgcctttg atgcatttac ctttgatttc tatgcttcta tgctgaatgc 380521 ggcacggctc attatcgcag atgaacatac gctgcttgat acagaacggc tcacagatct 380581 gatcctgcaa gagaatgtca atgtcatgtt tgcgacaacc gcactattta atcttctcac 380641 agatgcggga gaggattgga tgaaggggct tcgctgtata ttattcggcg gagagcgcgc 380701 gtcagtgcct catgtcagaa aagcgctgcg gatcatgggg ccgggcaagc tgattaactg 380761 ctacgggccg actgagggaa cagtgtttgc gacagctcac gtcgtgcatg atctgccgga 380821 ttccatctcc tcattgccga tcggaaagcc gatcagcaat gccagtgttt atattctgaa 380881 tgagcaaagc cagctccagc cattcggggc ggtcggtgaa ctgtgcatca gcggaatggg 380941 cgtgtcaaaa gggtatgtaa atcgtgctga cctcacgaag gaaaagttta tcgagaaccc 381001 gttcaagccg ggagaaacgc tttaccgtac aggggattta gcgcgctggc tgccggatgg 381061 aacgattgaa tacgccggcc gtattgacga ccaggtcaaa atacgcggac accggattga 381121 gcttgaagaa atcgaaaagc agctgcagga atacccaggt gtgaaagatg cggtcgttgt 381181 ggcggaccgc catgagtctg gcgatgcatc aatcaatgcc taccttgtga accgaacgca 381241 gctttcagct gaagacgtga aggcgcacct gaaaaaacag cttcctgctt acatggtgcc 381301 gcaaaccttt accttcttgg atgagcttcc tttaacgacg aacgggaaag tcaataaacg 381361 gctgctccca aaacctgatc aggatcagct ggcggaagaa tggattggac cgcggaacga 381421 gatggaagaa acaatcgcac aaatatggtc tgaggttctc ggcagaaagc aaattggcat 381481 tcatgacgat ttctttgcgc tcggagggca ttccttgaag gccatgaccg ccgcgtcccg 381541 catcaagaaa gagctcggga ttgatcttcc agtgaagctt ttgtttgaag cgccgacgat 381601 cgccggcatt tcagcgtatt tgaaaaacgg gggctctgat ggcttgcagg atgtaacgat 381661 aatgaatcag gatcaggagc agatcatttt cgcatttccg ccggttctgg gctatggcct 381721 tatgtaccaa aatctgtcca gccgcttgcc gtcatacaag ctatgcgcct ttgattttat 381781 tgaggaggaa gaccggcttg accgctatgc ggatttgatc cagaagctgc agccggaagg 381841 gcctttaaca ttgtttggat attcagcggg atgcagcctg gcgtttgaag ctgcgaaaaa 381901 gcttgaggaa caaggccgta ttgttcagcg gatcatcatg gtggattcct ataaaaaaca 381961 aggtgtcagt gatctggacg gacgcacggt tgaaagtgat gtcgaagcgt tgatgaatgt 382021 caatcgggac aatgaagcgc tcaacagcga agccgtcaaa cacggcctca agcaaaaaac 382081 acatgccttt tactcatact acgtcaacct gatcagcaca ggccaggtga aagcagatat 382141 tgatctgttg acttccggcg ctgattttga catgccggaa tggcttgcat catgggaaga 382201 agctacaaca ggtgtttacc gtgtgaaaag aggcttcgga acacacgcag aaatgctgca 382261 gggcgaaacg ctagatagga atgcggagat tttgctcgaa tttcttaata cacaaaccgt 382321 aacggtttca taaatgaagt gatgaaagga ggagacagcc aatgagccaa ctcttcaaat 382381 catttgatgc gtcggaaaaa acacagctca tctgttttcc gtttgccggc ggctattcgg 382441 cgtcgtttcg ccctctccat gcttttttgc agggggagtg cgagatgctc gctgccgagc 382501 cgccgggaca cggcacgaat caaacgtcag ccattgagga tctcgaagag ctgacggatt 382561 tgtacaagca agaactgaac cttcgccctg atcggccgtt tgtgctgttc ggacacagta 382621 tgggcggaat gatcaccttc aggctggcgc aaaagcttga gcgtgaaggc atctttccgc 382681 aggcggttat catttctgca atccagccgc ctcatattca gcggaagaaa gtgtcccacc 382741 tgcctgatga tcagtttctc gatcatatta tccaattagg cggaatgccc gcagagcttg 382801 ttgaaaataa ggaggtcatg tcctttttcc tgccttcttt ccgatcagat taccgggctc 382861 ttgaacaatt tgagctttac gatctggccc agatccagtc gcctgttcat gtctttaacg 382921 ggcttgatga taaaaaatgc atacgagatg cggaagggtg gaagaagtgg gcaaaagaca 382981 tcacattcca tcaatttgac ggcgggcaca tgttcctgct gtcacaaacg gaagaagtcg 383041 cagaacggat ttttgcgatc ttgaatcagc atccgatcat tcaaccgtga tcaaaagcgg 383101 acagcttcgg ctgttccgct ttttttgtgt tgaatgccaa tttctgcatg gtataatagt 383161 cgaaatactc aaataaaggc aggtcgaaac atgcgcacgt ctcccaggat gaaatggttt 383221 gtattgctgt ttacgtttgt tttcgccatc ggaatgaact cattcagaaa ttcctttcaa 383281 ttttttatgc tgccaatggc agacgccttc catgccgaca ggtcgctgat ttcggtttct 383341 gtcagcattt ttatgatcac aaccggcatc gtccagtttt ttgtcggttt ttttatcgac 383401 cgtttcagtg tcagaaaaat tatggcgctg ggagctgttt gcatcagcgc aagctttttg 383461 gtgcttcctt attcaccgaa tgttcatgtg ttttccgcca tttacggtgt gcttggcgga 383521 atcgggtatt cctgcgcggt cggcgtgacg acccagtatt tcatcagctg ttggtttgac 383581 acacacaaag gtctggcgct tgctattttg accaatgcca actctgcggg cctgctgctt 383641 ctctcgccca tttgggctgc ggctccgtat catgccggct ggcagagcac ctataccatt 383701 ttgggaatcg tcatggcggc tgttctgctg ccgctcctcg tctttgggat gaagcacccg 383761 ccacatgcgc aagcggaaac tgtgaaaaaa tcttatgatt ggcgagggtt ttggaacgtg 383821 atgaagcaat cccgcctcat tcatatcctg tacttcggcg tgtttacttg cggatttaca 383881 atgggaatta ttgatgctca cctcgtcccg atactgaagg atgcgcatgt ctctcatgtc 383941 aacggaatga tggccgcgtt cggggcattt atcatcattg gcggattatt ggcgggctgg 384001 ctgtcagatc tcctcggcag cagaagcgtc atgctatcca tcttattttt cattcggctg 384061 ctcagcctca tttgcctgct cattcccatt ctcggaattc atcacagcga cctttggtac 384121 ttcgggttta tcctgttatt cgggctcagt tacacaggcg tgatcccgct gaccgcggcg 384181 tcaatttcgg aaagctatca aacaggattg atcggatcgc tgttaggcat caatttcttt 384241 atccatcagg ttgccggagc tctcagcgtg tatgcgggcg gtttgttttt tgacatgact 384301 catggttatt tactgattgt cgctgtgtgc atcgtgtttg tgggtttatc ggctgtaata 384361 gagctggtgc cgtttttaga taaacagaag gcaaaagaaa cccaccattc aatataaaag 384421 gatcagcact gtcaatgctg atccttttta aatttgagtt tttttgtttc ggtattttta 384481 aggataatct ccttgaatct gttcatctcc tcttcggagt gaaaaaaatg tttggggatc 384541 gcaatatatt ggccacttga tgtattgacc ctgaagatat ttttatattc gaaaacagct 384601 gtaatttcat cccaattgaa aatgaggtca tattttttag aacatatacg aattccttct 384661 tggttcagag tatatgttct tttggatttc atccgttcgt tcttcttgta tgctctggaa 384721 aacttcacat atagaagaag gaggagcagc agtgtaaaca gaacggacat cacgataatc 384781 aacatactgt tcataaacaa gttaagcgcg tcacttccat aaacgatacg gggccatccg 384841 ttaatgaagt taactgcagc aaatatggcg caaaacaata gaaagtaaaa gcatgatatt 384901 tttgcgattt gataaaaaaa gatttctctt acatccttaa aagtgatttc tcctggaaga 384961 ttgatacttt cactagcata ttgaatcata cggtaaacct acacctctaa ccatgttttt 385021 ccttttagtc tagcataatt tctcattttt ttgcaggcat accagggcgc tttgtttttt 385081 tctccagatt gatattgctc cccaccacgc caatcataat acaaacagcc ccggcaagat 385141 gataccaggc caggctttcg ttgagaatca caaatcctgc aatcatcgtc acaatggtag 385201 atacatgatt aaaagcgctc attttaaacg cctcaattcg cgacagcgta tagttagaca 385261 gaaatgaagt gacaagtgaa gacagcacgc ccaaatacac aatggcgaga acgaagccgg 385321 gctcccggaa cggcagaaaa taagtgccga ctgttcccgc cgctccgtga cgcacaaggg 385381 cgatggcgtt gaagacgaca aagccgatgg ctgacatgat gtaggtgagc tcggtcagct 385441 tgaaccgctg cgtcattttt ctggcagcag tattgtacat cgctgaagac aaagcggaca 385501 ataggatcag caaagaccct tttaagctgg ctgattccac gtcaacgcct ttcatcacaa 385561 aaataaacat gacgccggca acggataaaa ccgtgaaccc cttttgcgtc cacgttgggc 385621 gttcctttaa aacataagcg gcaaagacca tcgtgaaaat cggaatggct gcctgaataa 385681 ttcccgcttc agaggaggac gagtacacaa ggccgaatgc ctgaaagctg aaaaataacg 385741 cgggatacag cagggcgagc ggcaaaatgt caatgacgtc ctttacgcgg attgatagct 385801 ttacccagcc gaataagatc ggtacagtgg ccgcagcaaa cgcaatggtg aaccgatgcg 385861 ccaaaatatc aaacggctct gctgtttgca gtgcgatttt tacgaataga aaggataaac 385921 cgataatgaa cgaatataaa atagccgcta tataagcggg ggtttgctga tgtttaacca 385981 taatgggaag ggctccttta cctgaattgc agcgccggtc gctcccttta ttgtatggcc 386041 gcggtcagaa cggtacaatg agaaaaacaa tgaactgtac cggtacaaaa cagggggaga 386101 aggcatggag aaatatatga gtctattaac gaggatagag gagatgatgc aaagcacctc 386161 atatcaagaa ggagacaggc ttccatctat ccgtcagctg tccgcccgct accaagtcag 386221 caaaagcaca gtgatccgcg cgctgcagga gctggaaaag cgccacctta tctattctgt 386281 tccgaaaagc ggctattata ttgtgaaaaa gtcagggaaa tcaaaaagcg ggcagcctgg 386341 ccccatcgac tttgccacat ctgcgccgga tcccgatgtg tttccgtatc ttgattttca 386401 gcactgcatc aacaaagcga ttgatacata caaaaacgat ttgtttattt atgggacgcc 386461 aaaggggctt ccatcactca tccgcgtact ccgaaagctc ttggccactc aacaggtatt 386521 tgcggatgaa cggcatattt tcattacatc aggtgtccag caggcgttat ccttgctttg 386581 tgccatgccg ttcccaaatg ggaaagagaa gatcgccatt gaacagccgg gctaccattt 386641 gatggtcgaa cagcttgaga cacttgggat tcccgccatc ggggtgaaac gaacggaaga 386701 agggcttgat atagccaagg ttgagcggtt atttcaaaca gaatcgatta aattttttta 386761 tacgatgccg cgcttccata acccgcttgg gtgctcattg tcagagcgtg ataaacagga 386821 gcttgtgaga ctggcagaag cgtatgatgt ctatctcgtt gaggatgatt acctcggtga 386881 tctggaggaa aataaaaagg cagatccgct gtacgcatat gatctgtcct cacatgtcat 386941 ctatttgaaa agcttctcga aaatgatgtt ccccggcctc cgcgtggggg cggctgtttt 387001 gcccgaagcg ctgactgaca cgttctatgc gtacaaaaag ctgaacgaca tcgactgttc 387061 gatgatttct caagcggcat tggagattta cctgaaaagc ggtatgtacg gcaggcataa 387121 ggagaaaatc agagattctt ataaagagcg gtcgctgagg ctacatcaag ccattcgaac 387181 tcacaggcag ctgggaagcg gacgctttac gttctccagc gggcaggcac cctgtatgca 387241 cacccatctg gtgcttcctc aggatctgcc cgcctcaaga gtgattcata gactggaaaa 387301 acaaggggtt ctccttgagg cgatagaccg tcattattta tcagattatc cgaaagaaaa 387361 tctattaaaa atcaatattt ccaatgtgaa aacggaagat attgagcgcg gtgtcaagct 387421 gttgatgagc catttataaa agctcttcgt acgagaccat tgtgatatcc tcggggaaat 387481 cagggtgtac ggcgcataca gccattttgt agccgggatc gacctcatac gttttgatat 387541 agcatgggga atggctgtcc ggaagctcaa tggatacttg tccgtcctgg tgcaggcgca 387601 ctgaaaagga atcaagcgga agcgataagc ctttgccttc cttgtttgat aaagctttct 387661 ttcattgacc atagatgata aaaatagtct gtctgctcgt ccttgtcttt tgctaaaagg 387721 tcgctgtact ctgtttttga aaagaagcgc ttggcgatct caaggctgat cggtttcgtt 387781 ttttcgatat ctatgccgat cggctgtgaa tcaaacgcgc aaatgaccca gcgtccggag 387841 tgagaaatgt tgaaatgagc gtcgggaaga tcagggatgc acggcttccc gtattcctgc 387901 gtgctaaagc ggatatcgga tttgtccaac tgatactgcc tgcttatgac tgagcgaacg 387961 agcacatctc ccagcagggt gcggtgagca tcttctttat gataaaatct ccggcatttc 388021 tcccgttttt caggtgatat gaaagacatg aaccgttcat tttcttcctg tgaaagcggg 388081 cggtccatat aaattccgta aatcttcatt ctagatcctc cgtctgcaaa agattgtcaa 388141 aaccatccta tcatacttcc acaagactca tatagaggag aaaataaaaa aacaaagcca 388201 aggcggcttt gttttagtgt acaggcggag atgctttcac tgcggctgtc cgccttgcca 388261 cagcataatt cagcaactgg attgactggg gcaatgaaaa acgcaaaata agtccggtga 388321 ggatggcggt caaaatggtg ccaaaaccga tcggtccgcc catgccccat gccgcaaaca 388381 aaatggttaa ttccatgccg ttccgcaccc attgcacatt ccagccggtt ttttctgtaa 388441 tcagcatcat cagtgaatca cgcggccccg cgccaaggcc tgctgataca taaacaccga 388501 cgccgtaacc aatcagcacc acgcctagag agaagacgat gatcgagcct gtgtaggtcg 388561 agagggcagg cagaatgaaa ttgaaaaaat ctataaatac accaatgagc accatattca 388621 ggagggcacc aattttcggc caagctctcg taaacaatga cgtgaatccg acgatgagcg 388681 ctccaataat gatggaccac tggccgacgg taagcccgaa gtgctgaaac aggctgtaat 388741 gaaatgcatc ccacggacta atgccgagtg cttttccttc tatcgtcagg gatacaccaa 388801 aagccaaaat gatcaaaccg gcaaaataaa atgtccagcg cagaacaagt tcttgcttca 388861 cgtgaggtcc cttctttcgt aaaaatcagt cgattgtcat tgtagcacat ctgacagaag 388921 ggcggaatag gcgaaagggg ctcaacaaaa aaacagggcc gccggaggcg ccctgtttca 388981 gcgtgttggc aaacccttgc attcgttgtc aggcctgtgc ttcggtgctc acgaatttaa 389041 cattagctgt gctccaatgc tcgcccttcc tagacttcaa aggttttcaa tcacgctgaa 389101 aatcacaaaa tcctaaaacg aatatcgttt taggattttg tcaataatct gaaacagggc 389161 gctgacgctc tgtttttctt attacagcgg gttcaaaatc cggtttaaga accgctgtgt 389221 ccgttcttct tttggtgcgg agaaaatttg ctccggcggt ccctgctcca cgataacgcc 389281 gccgtcgatg aagatgactt catccgcaac ctcctgcgcg aacttgattt cgtgggtcac 389341 gacgaccatg gtccagcctt cattggccaa gtccttgata accttcagca cctctccgac 389401 aagctcggga tcaagcgctg aggtcggttc gtcaaacagc atgagctcag gctgtatcgc 389461 cagtgcgcgg gcgatgccga cgcgctgctg ctggccgccg gaaagctgga acggatataa 389521 atccattttg tccttcaatc cgactttatc aagaagctga atcgcttctt ttctgacttc 389581 ctctttgttc cgtttttgca cctgaacagg gccctccatc acgttttcga gggctgtgcg 389641 gtgcgggaac aggtgatacg cctgaaacac cattccggat tttcggcgaa gctttaggat 389701 atccgcctgt ttcacctttt tggagaaatc gatggagaaa tcatcaaatg caagctctcc 389761 gcgattcggg atctccagag cgttcaggca gcggagcagc gtcgttttcc ctgaacctga 389821 aggcccaagt atggcgatga cttttccttt ttcaatcttc atatctatct tttttaaaat 389881 ttcattttca ccgaatgatt tgtttaatcc tttaacggta agcatactcg gaacctcctt 389941 atttggccac gtagcggtca agacgccgtt cgatgacatg ctggacgagt gagagcagga 390001 agcagataat ccaataaata aaggctgctt caatatagat cactaaaatt tgatcaagat 390061 tccgcgcgcc gatttcctgg gcttttctga acagctcagc gaccagaatt tgagaggcga 390121 gggatgtatc tttaatcagg ctgataaagg tattggataa tggcgggatc gacacacgaa 390181 acgcctgcgg caaaatgacg cggaacagcg ttttttgatg tgtcatgcca attgtgtagc 390241 cggcttccca ttgccctttc ggcacggata aaatagatgc ccgaatgatt tcagatgcat 390301 aggcgccgac gtttaatgaa aaggcgataa ctgcgcttgg aaatggatct aatgtgacgt 390361 taaaggccgg gaacagatag aaaatgatga acaattgaac gagaagagga gtgccgcgta 390421 ttgcggatac gtatacgctg aacacccatc tcaaaggtct cactttcgac attctggcaa 390481 gcgccgtaat cagcgccagg atcattccga atataaagga aagaatcgta aggggaatcg 390541 tatagtagat tccccctgaa agtatcggcc agaatgactg ctgcaccaga tcccacggga 390601 tcgccgtgcc aagcgtcaat gccggcagat tatttagaaa catcttcgcc gaaccatttt 390661 ttagaaattt tagaaagagt cccgtcctct ttcatttctt ttaatgcttt gttgacttga 390721 tcaacaacct cgccgcttcc tttacggaac gtgaaatatg ttgactgagg ctcacctgtt 390781 tcaaacgcga ttttcacgtt tttattgcca gatgttttta agtagttcaa tacggcaagc 390841 ttatcgttgt atgtcatatc gacgcggcct tgctggatca tttgaagggc ctgcgccatg 390901 ccttcaacgc cttctacttt agcgccggca tttgtagcta atttgttgta gttgcttgtc 390961 agtgattgag ctgacgtttt tccttttaca tctgcttcag acttaatatc gttgttgtct 391021 tttttcgtta cgacaacggc tcttgatgtt gtgtatttat ctgagaaatc atatttgtct 391081 tcacgatctg tttttccgac ttggttggca acaacgtcaa accgtttgga attcaggccg 391141 gcaaacatac tgtcccattg tgtttcctta aagtcgactt taagcccgag gcgttttgcg 391201 acttctgtga taacttcgac atcatagcca gtcagtttat cagtgtcttt gtcgtggtaa 391261 gtgaacggct catatgttcc ttccgttccg actgtgagca cacctttttt cttaattgaa 391321 gcccaaagat cgccatcttt ggcattatct tttgactgat tgtcatttcc tgctccgcaa 391381 gctgcaagag ctgcaatact tacgaccatg aataaagcca ataatgcttt tttcatctta 391441 ttccccactt ttctggttga ttttattgaa ataaaaaatt agcttacaaa tctaaaggat 391501 aacttttttt tagtatgagt caagtatttg gttttcataa gacaaaatct tttaaaataa 391561 atccaaaaat tgctgtgccg gtttaggcaa ataactgtcc gttctccaca tgacagccgg 391621 tgtcataatg aagggattat tttcgatatg gacggtgtga acgtgatttc tcatatgaac 391681 gggaatcatt gtgacaggca aaatagacgc gccgaatccg gatgacacga ggctgagcaa 391741 agttgcagag tcgtggcatt cacaaacaat gcgcggctcc aggttcaaac gatgaaattc 391801 attcatgacc tgattataga cgccttttcc gttgacaggc cgcagcagga tcagcggaaa 391861 tgaaggaatg tccaccatct taatggtgtc tccgcacgga tatccggctt catctgaaag 391921 cacgagcaca catggaatgt catcaagctg cttgaattgt actgtgtcac ttttgatcag 391981 tgttgtcgtg accgccgcat cgatttgccg gctttccagc agttccaaca gtgtcgcggg 392041 ttcattttcc caaatattaa aggtgagatg ggggtatctc tctttgatct gtgttacttt 392101 ttcaagcatc agagccgcgc aataaatcgt tgatcccacg gcaagtgtac cggctacttc 392161 ctccttcagc tcctgtacct caatgactgc atcttcaaac ctatgcagaa tctcttttgc 392221 tctttttaga aaaacagctc cttcatatgt aagagtcatt tgttttttct tgttacggtc 392281 aaacagaaca acaccaagtt cgtcctccag ctgtttgagc tgcctgctta aaggcggctg 392341 cgccatgtga agctttttgg ctgcggacgt aattttctgt tcttgggcaa tggtaatgaa 392401 gtatcgaagc tggcgaatat ccaaaagaaa gcgcctcctt atcatacctt ttaggtatta 392461 attatagatt taatagatat ttttcatatg gatatatcag gagtatgatt gaaatgaaag 392521 cagaattcaa gcgtaaagga gggggcaaag tgaaactcgt tgtcggaatg acaggggcaa 392581 caggggccat tttcggggtc aggctgctgc agtggctgaa ggccgccgga gtggaaaccc 392641 atctcgttgt gtctccttgg gcaaacgtca cgatcaaaca cgaaacaggc tatacgttac 392701 aagaagtaga acaactggcc acatacactt actcacataa ggatcaggcg gcagccattt 392761 caagcgggtc gtttgatacc gatggaatga ttgttgcgcc gtgcagcatg aaatctctcg 392821 caagcattcg cacaggaatg gcggataatc tgctgacacg tgcggcggat gtcatgctca 392881 aggagagaaa aaaactcgtc ctcttaacga gagagacgcc tttgaaccaa attcatctcg 392941 aaaatatgct agcgcttacg aaaatgggca ccatcattct tcctccgatg ccggcatttt 393001 ataatcggcc gagaagctta gaggaaatgg ttgaccatat tgtttttaga acgttggacc 393061 aattcggcat tcggcttcct gaagcgaagc gctggaatgg gattgaaaaa caaaaaggag 393121 gagcttgatc atggcttatc aagatttcag agaatttctc gctgcccttg aaaaagaagg 393181 acagctgctt acagtgaatg aagaggtaaa gccggaaccg gatttagggg cctccgcacg 393241 ggcagccagc aatcttggcg ataaaagccc tgcgctctta tttaacaaca tttacggcta 393301 tcataacgcg cgaattgcga tgaatgtcat cggctcttgg ccaaaccatg ccatgatgct 393361 gggcatgccg aaagacacac cggtaaaaga acagtttttt gaattcgcaa agcgttatga 393421 ccagtttccg atgccggtca aacgtgagga aacagcgcca tttcatgaaa atgaaatcac 393481 agaagatatc aatttgttcg atatactgcc tcttttcaga attaaccagg gtgatggagg 393541 ctactattta gacaaagcat gtgtcatttc ccgtgatctt gaggaccctg acaacttcgg 393601 caaacaaaat gtcggcattt acagaatgca agtcaaagga aaagaccgcc ttggcattca 393661 gcctgtcccg cagcacgata ttgcaatcca tctgcgccaa gctgaagaac gcggcatcaa 393721 ccttccggtc actattgcgc tcggctgtga gccggtcatt acaacggcgg catcgactcc 393781 gcttctctat gatcaatcag aatacgaaat ggcaggtgcg attcaaggcg aaccatatcg 393841 catcgtcaaa tcaaagctgt ctgatcttga tgttccgtgg ggcgctgaag tggtgcttga 393901 aggtgagatt attgccggag agcgcgaata tgaagggccg ttcggtgaat tcacaggcca 393961 ttattccggc ggacgcagca tgccgattat caaaattaaa cgcgtctatc acagaaacaa 394021 tccgatcttt gaacatttat acttaggcat gccttggaca gaatgcgatt acatgatcgg 394081 cattaacaca tgcgtgccgc tttatcagca gttaaaagaa gcgtatccga acgaaattgt 394141 ggcagtgaac gccatgtaca cacacggttt aatcgcgatt gtttccacaa aaacccgcta 394201 tggcggattt gcgaaagcgg tcggcatgcg cgcactcaca acgccgcacg gactcggcta 394261 ctgcaaaatg gtcatagtcg ttgatgagga tgtcgatcca ttcaaccttc cgcaggtcat 394321 gtgggcgctt tcgaccaaaa tgcatccgaa acatgatgcg gtcatcattc cggacttatc 394381 tgtcctgccg cttgatccgg gatccaatcc atcaggaatc actcacaaaa tgattctcga 394441 cgccactaca ccggttgcgc cggaaacaag aggccattat tcacagccgc ttgattctcc 394501 gctaacaacg aaagaatggg aacaaaaact aatggactta atgaataaat aaggaaagga 394561 tgttcgaaat gcatacatgt cctcgatgcg actcaaaaaa gggagaagtc atgagcaaat 394621 cgcctgtaga aggcgcatgg gaagtttatc agtgccaaac atgctttttt acatggagat 394681 cctgtgaacc ggaaagcatt acaaatcccg aaaaatacaa tccagcgttt aaaattgatc 394741 caaaggaaac agaaacagca attgaagttc cggcggtgcc ggaacgaaag gcttgatccg 394801 cgtgaactgt atgtcagacc gtctctttga gctgcttgac gggagctgcc tgaatgagaa 394861 gcagcatgag gccttcgttc tgcaaacagt atcagaggat ggctggccgc atgccgctat 394921 gatcagtgca ggtgaaatca tcgcgctgag ccgaactgat atccgaatcg ctctgtggaa 394981 aaacacaatg acttcggcca acatccttcg cacaggaaaa gcacagttca cggcgtggtg 395041 gaagggagcg gcctattatg taaagcttga atgcgcgcct ttaccgcctt tgaaagatgc 395101 cgaatatgaa agagaccgtt tttcctgccg catcgtttca gtgaaagagg acgttgcgaa 395161 atacgctgat ttgacttcag gtgtccgtat acagcttcac agccctgaag aggtgctgag 395221 cagatggaaa aagaccctgg aagatttaaa acggtaatat cgatagcctg acgccatgcg 395281 tcaggctttt tttatataat gaaaacaaaa gggggcgtga gaaatggaac gtgcggggat 395341 ctgtcactcg gacggctttg atttagctta tcgaattgag ggcgagggcg cacccatcct 395401 tgtgatcggg agtgcggttt actatccgcg ccttttttcc tcagatatca aacagaaata 395461 tcaatgggtc tttgtcgacc ataggggatt tgctaagcct aagcgggagc ttcgtgcgga 395521 ggattcgagg cttgatgctg tcttggctga tatcgaaagg atgagaacat ttcttcagct 395581 tgaggatgtt actatcctgg gacattccgg gcacgctttt atggctttag agtatgccag 395641 gacatatccc aaacaagttc ggaaggtggc gctctttaat actgcgcctg ataacagtga 395701 agaaagacag cgaaaaagcg aatcattttt catggaaaca gccagtcttg agagaaagaa 395761 acgctttgaa aaagacatcg agaatttgcc gcaggacatc gacaaagatc ctgaaaggcg 395821 ctttgtgcac atgtgtattc gcgctgaagc gaaaagcttt tatcaagagc ggccgcatgc 395881 tgctgcctta tgggacggtg tattcacgaa tatgccgatc attgatgaat tatggggcaa 395941 tacatttgcc cggattgatc ttcttcagcg gttagctgat gttcgtatgc cggtgtatat 396001 cggattaggg agatatgatt atttggttgc gcccgtttcg ctatgggatg ctgttgacgg 396061 tttatatccc catgttgata aggttatttt tgaaaagagc ggccatcagc cgatgctgga 396121 agaaccggaa gcctttgatc aaagcttcag gaaatggctt gatcaataaa aaacagcccg 396181 cagatcaaca tccgcgggct gtttctgatt ataagacccc tttcatcgcg cgtttgatca 396241 ccggcgagag cagcaggaga atgccgccaa gaacgataga aatcaaaccg atggtgccga 396301 agtacattgt ttcaggaatt ttatcaaaca atccggctac ttgggcattg atcgcttggg 396361 ctgctgcgtt cgtcagaaac cacatactca ttgtctgtgc agagaaggca gctggtgcca 396421 gtttcgttgt cacggataaa ccgactggag acaggcacag ctctccaagc acgacaagca 396481 ggaagctgag aacgagccaa agcgggctta cgagtgcttc ttttccttgc atagcaggga 396541 ataccataat gataaatgac aatccggcta aaataattcc gattgagaat ttaactggtg 396601 tagacggctg acgtttgcca agcttcatcc agagccatgc gaatattggc gcaaaaatga 396661 caacaaacaa tggatttaat gattggaacc atgatgactg aagttcgaat ccgcccaatg 396721 aaagtcttat gcgttcatca gcgtataccg caagaatggt cgctccctgt tcctgaatgg 396781 cccagaacat gacagcaccg ataaacaaag gaacgtaagc ggcaagacgg gatttttctg 396841 ttttgtccgc ttttttgctt gtaaacatga tgatgaaata aatcacagga atcaaaatac 396901 cgagaatact tacaaggtca atgaaacgtt tgatcgtcag cacgcctgtt tgtacagaga 396961 taatcactgc gatcgccaca atgataacac cgattccggt gccaattgca gattttttag 397021 acagcggatt cggcacattg gaacctgcaa gcccgaggtt tttctttctt gtcaaagcaa 397081 atacgataag tccgagaagc attccgaccg cggcagctcc gaatccgaga tgatagttgt 397141 acttctgtcc gagtgttccg acaattaacg gcgcgagtaa accaccgagg ttaatcccca 397201 tgtagaaaat actgaaacct gagtcgcggc gcgggtcttc tttcgtgtaa agatccccaa 397261 ctacgcttga aacgtttggt tttaataagc ctgttccgac aatgataagc accatactga 397321 tatagaatgc tatcgaactg cccggatagg cgagtgcaat gtggccgaac ataatgaata 397381 tgccgccgta aaacacggtg tttgcggtac cgaatacccg gtcagcgagc catccgccaa 397441 taatggtgga catgtatacg agtgatccgt aaatcgacat aatggcaacc gcagtgccct 397501 tgtcaaagcc gagccctccg tttaccgtct ctgtatacaa atagtaaagt aagattgctc 397561 tcattccata gtaagagaaa cgctcccaaa attcggtgaa aaatagtgta aatagtcctc 397621 gcgggtgacc aaagaaccct ttttgcggga cgcttttaat gatactttcg ttatcaatcg 397681 aagccatgtc agccaaaccc tttctaaaaa aagtgtatta taaaaatcat attcttatat 397741 aatacttgtg tcaatataat ttatactcat ttcaaatagt tccatattgg aaaaattata 397801 aatacctaaa aatagtgatt tcctcctaat ttttaaactt tttatcgtga gattttctta 397861 cacaactatt cctttatatt tttttaataa aattttagag aaatgtacaa gcagatcggg 397921 aggaccgctg gtgaatcaat cccctgtaac ggggattttt ttatgtccgt aaaccgcttt 397981 gaaaagccgc tgcacaccct cctgaatatc ttcttccttc agccgtgcaa agccgataat 398041 gagagcaggc ctgcccgttt gccgcttgtt ttccttcaag ttaaatcggc tcattccgaa 398101 tatttcaagc tgcagcccgg cagcatgtga caggatgtct tgttcggtgc gcctggtatc 398161 aaattcggta acaaaatgca gccccgcatt tgcccctttt acggtaacct ctccgctgaa 398221 ctctgcttct aaagcggtga tcaggcgttc tctcttttct ttataatgct gcttcatttt 398281 ttttatatgc ttctgatatt caccagactc gataaattcc tgcagggtga gctgtgtgag 398341 tgatgagcaa gtctgcagat catagccccg ctgtttgtat gccctcaaca gctcaggcgg 398401 caacaccata tagctgatcc gtaagccggg gagaagggac tttgaaaagg ttcccatata 398461 gatgacattt tgaaaacggt cgaggctttg cagcgccgga atactgtcta catcatatgt 398521 gaattcacta tcataatcgt cctcaatgat atatcggcgc ggctcctcgg ctgcccagtt 398581 cagcagctga attcttctgg atacaggcat aatcgttccg gacggaaact gatgcgacgg 398641 ggtggtcacc agcacatctg gctgctgtct ggtgatttca gcaatcgaca tgcctttttc 398701 atccagcatg atcgtcttta cttgttttcc ggcattcttc aaaagctgat acatgcgcct 398761 gtagccaggc tcctccatcg catacacggc ttccttgggt aaaagctcag tcaacagctg 398821 catgagcacc tgtgtgcctg cccctatgat catttgttcc ggcctgcatt ttacacccct 398881 cgtcagggaa atgagcctcg taatggccgc tctcacttca tatatccctt gcggatgtga 398941 catatcgccg agcgtgcggt atgagcggga ggccgctttt tgctcgcagc ggaaccagct 399001 tttgatcgga aaatggtctg tatcggaact catgtgtgaa aacgatatcc aatcgctctg 399061 gtcgatgtga atctctttta ggtcatccgg cagtgcaaat ggagggtgct cctcggcgga 399121 aaacatgtct agttcctcca cgaagaaacc ctttcgttca atggcgtaca aatacccctc 399181 agccagcagc tgctgatagg ctgaattcac tgaatttacg ctgaccttga gattttcagc 399241 cagctcccgc ttggagggaa ccttcgagtg cggcagcaga ttgcggctga ggatttcttt 399301 tttcagcttt tgataaattt gctgatagat ataatcggct tgttctgaac gatcgagtgt 399361 aatcgtgata tccattttgt agtttctcct tctgatacca tcaaaaagtt ataattggta 399421 cttttcatca taccaaagag aagtcagaat gataagaaaa taccgacagg gggatattca 399481 catgagtcaa acaacagcaa gcatcacaac tgcacaatgg cagcaaaaac gggatcaatt 399541 tgtgtcaaaa ggtgtgagca acggcaaccg cagtctggcg gtcaaaggag aaggggccga 399601 gctgtacgat ctggatggcc ggagatttat tgattttgca ggcgccatcg gcacgttaaa 399661 tgtcggacac tcgcatccga aggtggttga ggctgtgaag cggcaggcgg aggagctgat 399721 tcatcctggt tttaatgtca tgatgtaccc gacttatatc gaattagcag aaaaactgtg 399781 cggcatcgcg ccgggcagcc atgagaaaaa agcgattttt cttaactcag gggcagaagc 399841 ggtcgaaaac gctgtgaaaa tcgccagaaa gtatacaaag cgccaaggcg ttgtctcgtt 399901 tacacgcggg tttcacgggc gcacgaatat gacgatgagc atgacaagca aggtaaaacc 399961 ttataaattc ggtttcgggc cttttgcgcc agaggtttat caagcgccgt tcccttatta 400021 ttatcagaag ccggccggca tgagtgatga aagctatgac gatatggtca ttcaagcatt 400081 caatgatttc tttatcgctt cagtggcgcc tgaaacggtg gcgtgtgtcg tgatggagcc 400141 agtgcaggga gaaggcggat ttattattcc ttcgaaacgg ttcgtacagc acgtcgcttc 400201 attctgcaaa gaacacggca ttgtttttgt tgctgatgaa atccaaaccg gctttgccag 400261 aactggcact tatttcgcaa ttgagcactt tgatgtagtg cccgatctga tcacggtttc 400321 taaatcgctt gcggcaggcc tgccattaag cggtgtgatc gggcgtgcgg aaatgcttga 400381 tgcggcagcg ccaggggagc tgggcggcac gtatgccggc agcccgctcg gctgcgcggc 400441 ggctttggca gtcttggata ttatcgaaga agaaggactg aatgagcgat ctgaagaaat 400501 tggcaaaatc attgaagaca aggcgtatga gtggaaacaa gaattcccgt tcatcggtga 400561 catccgcaga ctcggggcga tggccgcaat cgaaatcgtc aaggatcctg acacgcgtga 400621 gcctgataag acaaaagcag cagcgatcgc ggcctatgcg aatcaaaacg gattactttt 400681 gctgacagcg ggaattaacg gtaatatcat ccgctttttg acaccgctcg tcatctcaga 400741 cagcctatta aatgaagggc tcagcatctt ggaggcgggc ctgcgagctt aatcattgga 400801 aagaaaatgg ccgggtctgc tatcatttta agtaatcatg aaaagaaagg aatgttcaat 400861 atgccagatc aattaacggt ctacaacccg gctacgggcg aggagatcaa aacgattcct 400921 cagcaatcag ccacagaggt agaagaagcc attgaacgtt cacatcaagc gtttaaaacg 400981 tggtctaaaa catcagcgaa cgaaagaacg tctcttttga aaaaatggta tgagctgatt 401041 gttgaacata aagaagagct tgcagattta attacaaagg aaaacggaaa accataccag 401101 gaagcagtcg gcgaggtact ttacggcgca ggctatatcg aatggttcgc agaggaagcg 401161 aagcgtgtgt acggaagaac ggtcccggcc ccgacaactg gtaaacgaat tgttgtcaca 401221 cgccagccgg tcggccccgt tgctgctatc acgccctgga atttcccgaa tgcgatgatt 401281 acacgcaaag cggcgcctgc tcttgccgcc ggctgtacat ttatcatcaa gccggcgccg 401341 gacacaccgc tgtctgctta tgaactagcg cgcctcgcat atgaagcggg cattccgaag 401401 gatgttcttc aggttgtgat cggcgatgga gaagaaatcg gaaatgtgtt cacaagcagt 401461 ccgaaaatcc gcaaaatcac gttcacaggc tcaacacctg tagggaaaat ccttatgaaa 401521 aacagcgctg acaccgtaaa gcacgtctca atggagctcg gcggacacgc cccgctgatc 401581 gtagatgaag atgcggacat tgaccttgcc gttgaacagg cgatggcgtc caaataccga 401641 aacgccggcc aaacctgcgt atgtgccaac cgcctgatcg ttcatgaatc cattaaagat 401701 gaatttgctg cgaaactgag cgagcaagtg tctaagctga aagtcggaaa tggacttgag 401761 gaaggcgtca atgtcggccc gattatcaac aaacgaggct tcgaaaaaat cgtcagccaa 401821 atagatgatg cggttgaaaa aggcgcgaaa gtgattgctg ggggcacata tgaccgaaac 401881 gatgacaaag ggtgctactt tgtgaatccg acagtgctca ccgatgtcga tacgtccatg 401941 aacatcatgc atgaggaaac attcggcccg gtcgccccga tcgtcacgtt ttctgatatt 402001 gatgaagcga ttcagcttgc caacgataca ccgtatggct tggctgctta cttcttcaca 402061 gaaaactacc gccgcggcat ctatatttcc gagaatctag agtatggcat tatcggctgg 402121 aatgacggcg gaccgtcagc ggttcaagcg ccattcggcg gaatgaaaga aagcggcatc 402181 ggccgtgaag gcggttcaga aggtatcgag ccgtaccttg aaacaaaata tttgtccatc 402241 ggtttataaa agaatgcacg ctcctgagag ctgccggatt ttccggcagc tctttttgtg 402301 ttccggcgaa taatcacaac aattccagcc aaaataacag caaatacatt ttgaaagaag 402361 gttccccaac aatggattta ttattggctc ttctcccggc tttgttttgg gggagcattg 402421 ttctcttcaa tgtgaaatta ggcggcgggc cgtacagcca gacactggga acgacgatcg 402481 gggcactcat tgtttctatc gttatttact tttttgttca gcccgttctg tcccttcgca 402541 tttttattgt tggaatcgta tccggcttat tttggtcact tggacaggcc aaccagttga 402601 aaagcattca attgatgggc gtgtcgaaaa caatgccgat ttccacagga atgcagctcg 402661 tttccacctc gctgttcggt gtgatcgtgt tccgcgaatg gtcaacaccg attgcgatta 402721 cgcttggcgt tctcgctttg atctttatca ttgtgggaat cattctcacg tccttggaag 402781 ataagaatga taaaaaagag ggcgagccaa gcaatttgaa aaagggcatt ttgattctcc 402841 ttgtttcgac tcttggttat ttggtttatg tagtcgtggc tagattattc aatgtgtccg 402901 gctggtccgc gctgctgcca caggcaattg gcatggtggt cggggggtta gttttaacct 402961 atagacacaa accctttaac aagtatgcga tcagaaatat tctcccaggg ttaatctggg 403021 caggcggaaa tatgtttttg tttatttctc agccgcgagt cggcgttgca acgagctttt 403081 ccctttcaca aatgggaatt gtcatttcta cgctcggcgg tattttcatc ctgcgtgaaa 403141 agaaaacgaa acgccagcta atagcaattg cgatcgggat tatcctgatt attgccgccg 403201 ccgtattctt aggaatcgcc aaaacaaatt cataacaaat ggaggaggat gtatatgtat 403261 ccggatttaa aaggaaaagt cgtcgctatt acaggagctg cttcagggct cggaaaggcg 403321 atggccattc gcttcggcaa ggagcaggca aaagtggtta tcaactatta tagtaataaa 403381 caagatccga acgaggtaaa agaagaggtc atcaaggcgg gcggtgaagc tgttgtcgtc 403441 caaggagatg tcacgaaaga ggaagatgta aaaaatatcg tgcaaacggc aattaaggag 403501 ttcggcacac tcgatattat gattaataat gccggtcttg aaaatcctgt gccatctcac 403561 gaaatgccgc tcaaggattg ggataaagtc atcggcacga acttaacggg tgccttttta 403621 ggaagccgtg aagcgattaa atatttcgta gaaaacgata tcaagggaaa tgtcattaac 403681 atgtccagtg tgcacgaagt gattccttgg ccgttatttg tccactatgc ggcaagtaaa 403741 ggcgggataa agctgatgac agaaacatta gcgttggaat acgcgccgaa gggcattcgc 403801 gtcaataata ttgggccagg tgcgatcaac acgccaatca atgctgaaaa attcgctgac 403861 cctaaacaga aagctgatgt agaaagcatg attccaatgg gatatatcgg cgaaccggag 403921 gagatcgccg cagtagcagc ctggcttgct tcgaaggaag ccagctacgt cacaggcatc 403981 acgttattcg cggacggcgg tatgacacaa tatccttcat tccaggcagg ccgcggttaa 404041 acataaaaag cgacccagac atgacatctg gatcgctttc tttattaggc acgctttttc 404101 tttacaagtg ctgctacaga taaaataatg gcagccgcag acagcaccat cgctgtaatg 404161 tctagagctg aagaacctga gttttcggaa tcgtcttctg ttttcgtggc gccgtgctca 404221 tctgtcactt gctttgcaga cgtgatgttt gtaatggaat gaggtgtatc ggcatcctcg 404281 tcacctgtcc actcaacaat gctgccgtct ttgtaatatt ggtatgcgtc ccaagcagct 404341 tcctccgctt tgtcagggtt tttggcaaca aaggtaaact gctggaactg gccttcctga 404401 atgcctccgt cagtcgcctc ccatgtcacg gatactgatt tgtcatcatg tttttgagtg 404461 gaaaccttcc agcccggaat tggctcatat tgctggaatt caacatcctt cggcattttg 404521 aggacaacct tcgttgtcgg cagatttttc tcagaaggaa ccttcattgt atacgtttcc 404581 caagagcctg cagcagactc agccggtttt acagaaacat gcgcgctggc aggggccgta 404641 aagaataaga gggagccgac aatagccgga catagtgtca atgcgatttt tttcaacaac 404701 gtaaacactc cttaattggt ctttgtaaac atgatattga tttcgttaaa gtcgccggtc 404761 aggccgtgga ctttgatctt ccagtttcct ttttcattaa tcgacaggtt ttgatcttgg 404821 aagacgcctt ttgttttttc ttttaatgta aaggtgcttt tgttttcgct gcctgacagg 404881 cctgttttat aaacggttaa cgtgatttgc tggatgtttt tcacgggatc accgttatgg 404941 tcggtgaccc gcagctcaaa aacatttttt ccaggctggt ttgggctgat gctgagagaa 405001 acgctttgtc cgttctctat cgctttggtt tggtagaacg gttccggcgc tggctcaggc 405061 gggcttggca ggcttgtaaa cacggccgct gtgatcaata cagcgatgcc gattgcccac 405121 tccgctttca acgttcggct gattcctgtg cggcgctgct ttctggtaag cagaaaatga 405181 attgcgccta agaccagcat gaaaacaaac agcccgcttt tcactaaaag agcttgtccg 405241 tacgctgtat ggaacagtga atccattgaa cgaatgatga aaaatccatt gagcaagcct 405301 gaaaacaaaa tgacgccgac tgcagtgagc gcccatgggg agaaccgtct gaccgtctcc 405361 cacgcgagcg ttttgtcagg ctgcctccat tcttttgaga gcagcaaaac gagtgccgct 405421 attccgccga cccagatgga agcggaagtt aaatgaagga aatccatcaa aatgccgacc 405481 gttttttctt caacgacagc agcatgcccg gtaaacgcct tggcaagcag gagaccgaaa 405541 aagaaaatga gcggcgctgt ccaatagcca aaggatgaaa agcggttttt ccgtatcgca 405601 gggatgacag acagtgcgag cagcacgaac agcgcagcct gtatgatcca aatggagccg 405661 cctgctgtct caaacagtgt ttctctgatg tagcccggct ggaatgcgct gccccagccg 405721 ccgcctgcgt tcgcttttgt ctgaatcgga agctgaagca aaagcgccag ccccaatgct 405781 gcgatcgagc cggtcaggat acgtctcgtc cgtttgacga gctgttctga tttcccttta 405841 taccagaaaa gatggaagaa aaccgttccg ataaacagag ataaggctgt atacagaatc 405901 gcgcgatctg ctgctgttcc cggattcagc gctgaatcgg ctgctttttg gctgctgaat 405961 ccgccatccg ctttcccgat actgaacgga atgacgccgg aaacaggatg tccatccgcg 406021 gatacggcat tccattccgc tctgtacaca tctttaggca gattcttctt cagcttcact 406081 gtcatgatgt gatgattatc ttttttgatt tcagtcttgt ccgtatccac acggtcgccg 406141 tttgaattat agactttaat gtaatgaaac ccttcttcaa ccggttcatt aaattcgatt 406201 tccacctgcg caggggcgct ttttaattcg ctgttttccc caggtgaaga tttgacaata 406261 taggcgtgag caaagcttgt tttcggcagg aaaacaagaa aaagcagaag gatgatccac 406321 catctgtttc gcttcatcac tcagacacca ccttccgctg tatgtgttgt gttatttctt 406381 ggtgcaggtg cagcgtttct ttcggtcttg aagcatgtct tccagcgctt ggtcgaaagt 406441 gcagacggct ccgccgaatc ctttttgaaa tcgttcggca tggtcaagtg tcgcaaacgg 406501 aatggcctgc ggctggcagc agtgcaggtt taattcagca tttacgacga aataagccga 406561 accggcactg acggttgtct gtaacagaaa atctctgcaa atcaagtgtg aaacctcttc 406621 cgttttatcc gcgtaacgca aaaacgcgca atgtgcgcag catagctgtt caatgtcttg 406681 gtttaccgta atcagctgaa ccgaatgagc ttgattgacg ggcttcaagc aatagctgca 406741 catatgatct gtttgaggtg ttcggacggg gagcgtgatg ccgccggccg ttttaatgac 406801 ctgatttgac tgaaccagct gattgacatc tctatatacc gtcatttccg aaacgccgaa 406861 ccttgcgctg atgtcagaaa ttctaagcga gccttcttct ttcagccact tcagtatgtg 406921 ttgctgtcta ttaatcggaa gcattcatac accctcttca ttaagatcta tttaagcgta 406981 gaggatttta gagacggaga caagtaagtg gatgataaaa aatgtgaaaa tgtgttgaac 407041 agcaacaaaa cgaaacagaa gggactctgg tataatagac agatggaata gaaagtgagg 407101 aataccctat gaaagaaaca ccatgcccga actgcggcaa acctttgaca ggcgatatgg 407161 tcagatcatc aaatgtgcct tgtcaatttc gctgcggcca ctgccgggaa cggctttatg 407221 aatataaagt ttcagctccg attatgctgg tatcattagc ggccatcgtg ctgcttattt 407281 atcttttgat gctcctccgc aatgcggcag gctcagtgct gccagctgta cagcacgtgc 407341 cgatggctgt atttgcgctt gtgtgcgcgt atcccgtttt tattgtgagt gagcggatga 407401 ttgcaaagta cgtgattcaa aatggcaaca tcatttatag aggaaagaga aaaggctcct 407461 gaaaccagga gcctttttat ttttaaaaaa ttgtcacagt catgtgccaa agtcctcttt 407521 actttcaatt gtatagggac tgtaagcgtt ttaacataga gtcaaaggga agcatcattc 407581 tctgaacata tttttgtatc ttacagcgac aaacaaaaca gggagggttt atatatgcag 407641 cagcaagaac agcagcaagg cggcatgaaa gtgaaagtgc aacgctttgg gagttatttg 407701 agcggaatga tcatgccgaa tatcggcgcg tttatcgcgt ggggtatcat taccgcgctg 407761 tttattccgg caggatggtt tccgaatgaa cagctgaaca cgctggtcag cccgatgatt 407821 acgtatttat tgccgctttt gatagcgtat acaggcggaa aaatgatcta cgaccaccgc 407881 ggcggagttg tcggagcgac agcggcaatt ggggtgattg taggatcgga tattccaatg 407941 tttttaggcg caatgattat gggtccgctt ggcggatacc tcattaaaca gactgataaa 408001 ttattcaagg ataaagtcaa gcaaggcttt gaaatgctga tcaacaactt tacggcaggg 408061 attgtcggcg cggctttaac gattctcgcg ttttacgcca tcggcccggt tgtcttgacg 408121 ctaaataaat tgctggcggc tggtgtggaa gtcattgtac acgctaattt actgccggta 408181 gccagtgttt ttgtagaacc ggcgaaagtg ttgttcctta acaacgccat aaaccatgga 408241 atcttaagcc cgatcggaat cgagcaagca tctcaaacag gaaaatcaat tctgttttta 408301 gtagaagcaa accctggacc ggggctcggc attttgctgg cctacatgtt ctttggcaaa 408361 ggatcttcaa aatcaacggc tcccggtgcg gcgatcatcc atttcttcgg agggattcac 408421 gagatttact tcccgtacat tctgatgaaa ccggccctga ttctcgcagc cattgccggc 408481 ggagcaagcg gactcttaac atttacgatc tttaatgccg gacttgtcgc ggcagcgtca 408541 ccgggaagca ttatcgcatt gatggcaatg acgccaagag gaggctattt cggcgtattg 408601 gcgggtgtat tggtcgctgc agctgtatcg ttcatcgttt cagcagtgat cctgaaatcc 408661 tctaaagcta gtgaagaaga cctggctgcc gcaacagaaa aaatgcagtc catgaagggg 408721 aagaaaagcc aagcagcagc tgctttagag gcggaacaag ccaaagcaga agaagcgtct 408781 gagctgtctc ctgaaagcgt gaacaaaatt atctttgcgt gtgatgcggg aatgggatca 408841 agtgccatgg gggcatccat cttaagaaac aaagtgaaaa aagcggagct tgacatcagt 408901 gtgaccaaca cggccattaa caatctgcca agcgatgcgg atattgtcat cacccacaaa 408961 gatttaacag accgcgcgaa agcaaagctg ccgaacgcga cgcacatatc agtggataac 409021 ttcttaaaca gcccgaaata cgacgagctg attgaaaagc tgaaaaagta atcttataga 409081 aagagagtga ttgtcatgca agtactcgca aaggaaaaca ttaaactcaa tcaaacggta 409141 tcatcaaaag aagaggctat caaattggca ggccagacgc tgattgacaa cggctacgtg 409201 acagaggatt acattagcaa aatgtttgaa cgtgaagaaa cgtcttctac gtttatgggg 409261 aatttcattg ccattccaca cggcacagaa gaagcgaaaa gcgaggtgct tcactcagga 409321 atttcaatca tacagattcc agagggcgtt gagtacggag aaggcaacac ggcaaaagtg 409381 gtattcggca ttgcgggtaa aaataatgag catttagaca ttttgtctaa catcgccatt 409441 atctgttcag aagaagaaaa cattgaacgc ctgatctccg ctaaaagcga agaagatttg 409501 atcgccattt tcaacgaggt gaactgacat gatcgcctta catttcggtg cgggaaatat 409561 cgggagagga tttatcggcg cgctgcttca ccactccggc tatgatgtgg tgtttgcgga 409621 tgtgaacgaa acgatggtca gcctcctcaa tgaaaaaaaa gaatacacag tggaactggc 409681 ggaagaggga cgttcatcgg agatcattgg cccggtgagc gctattaaca gcggcagtca 409741 gaccgaggag ctgtaccggc tgatgaatga ggcggcgctc atcacaacag ctgtcggccc 409801 gaatgtgctg aagctgattg ccccgtctat cgcagaaggt ttaagacgaa gaaatactgc 409861 aaacacactg aatatcattg cctgcgaaaa tatgattggc ggaagcagct tcttaaagaa 409921 agaaatatac agccatttaa cggaagcaga gcagaaatcc gtcagtgaaa cggtaggttt 409981 tccgaattct gccgttgacc ggatcgtccc gattcagcat catgaagacc cgctgaaagt 410041 atcggttgaa ccatttttcg aatgggtcat tgatgaatca ggctttaaag ggaaaacacc 410101 agtcataaac ggcgcactgt ttgttgatga tttaacgccg tacatcgaac ggaagctgtt 410161 tacggtcaat accggacacg cggtcacagc gtatgtcggc tatcagcgcg gactcaaaac 410221 ggtcaaagaa gcaattgatc atccggaaat ccgccgtgtt gttcattcgg cgctgcttga 410281 aactggtgac tatctcgtca aatcgtatgg ctttaagcaa actgaacacg aacaatatat 410341 caaaaaaatc atcggtcgct ttgaaaatcc tttcatttcg gacgatgtga cccgcgtagc 410401 gaggtcacct ctcagaaaac tgggagaaaa tgatagactt gtaggcccgg caaagaaaat 410461 aaaagaaccg aatgcactgg ctgaaggaat tgccgcagca ctgcgcttcg atttcaccgg 410521 tgaccctgaa gcggttgaac tgcaagcgct gatcgaagaa aaaggataca gcggcgtact 410581 tcaagaggtg tgcggcattc agtcccatga accgttgcac gccatcattt taaagaaact 410641 taatcaataa ccgaccaccc gtgacacaat gtcacgggct ttttttacta tctcgcaatc 410701 tagtataata gaaagcgctt acgataacag gggaaggaga atgacgatga aacaatttga 410761 gattgcggca ataccgggag acggagtagg aaaagaggtt gtagcggctg ctgagaaagt 410821 gcttcataca gcggctgagg tacacggagg tttgtcattc tcattcacag cttttccatg 410881 gagctgtgat tattacttgg agcacggcaa aatgatgccc gaagatggaa tacatacgct 410941 tactcaattt gaagcagttt ttttgggagc tgtcggaaat ccgaagctgg ttcccgatca 411001 tatatcgtta tgggggctgc tgctgaaaat ccggagggag cttgagcttt ccattaatat 411061 gagacccgcc aaacaaatgg caggcattac gtcgccgctt ctgcatccaa atgattttga 411121 cttcgtggtg attcgcgaga acagtgaagg tgaatacagt gaagttggcg ggcgcattca 411181 cagaggcgat gatgaaatcg ccatccagaa tgccgtgttt acgagaaaag cgacagaacg 411241 tgtcatgcgc tttgccttcg aattggcgaa aaaacggcgc agccatgtga caagcgccac 411301 aaagtctaac ggcatttatc acgcgatgcc gttttgggat gaagtctttc agcagacagc 411361 cgctgattat agcggaatcg aaacatcatc tcagcatatt gatgcgctgg ccgctttttt 411421 tgtgacgcgt ccggaaacgt ttgatgtcat tgtggcgagc aacttgttcg gtgatatttt 411481 aaccgacatc agctcaagcc tgatgggaag catcggcatt gcgccttctg cgaacatcaa 411541 tccatccggc aaatatccgt ccatgtttga accggttcac ggctcagctc ctgacattgc 411601 cggacagggc cttgccaatc cgatcggcca gatttggaca gcgaagctga tgctcgacca 411661 cttcggagag gaagaattgg gggcgaaaat tctggatgta atggagcaag tgactgccga 411721 cggcatcaaa acacgcgaca ttgggggaca aagcacaacg gctgaggtca ctgatgaaat 411781 ctgttcgcgc ttaagaaagc tctgatgaat caggccggtg gcagatggct gccccggcct 411841 gtccatttcc ttacgaaaat ttccacgaaa gtctaaccaa gcagatccaa atgctgtata 411901 ataatttgga attcttagga aagcatcggg tgaaggaagt tgaatgcaaa aacaatcacg 411961 ttaaagaaaa aaagaaaaat caaaacgatc gttgtactca gtatcattat gatcgcagct 412021 ctcattttta cgatcagatt ggtgttttac aagccttttc ttattgaagg atcatcaatg 412081 gccccaacgc ttaaagactc agaaagaatt ctggttgata aagcagtcaa atggactggc 412141 gggtttcaca gaggagacat catagtcatt catgacaaaa agagcggccg ctcatttgtc 412201 aaacgtttaa tcggtttgcc tggtgacagc attaaaatga aaaatgatca gctatacata 412261 aatgataaaa aggtggaaga accatactta aaggaatata aacaggaggt caaagagtcg 412321 ggtgtaacct taacaggtga cttcgaagtt gaggttcctt ccggtaaata ttttgtgatg 412381 ggagataacc gtctcaattc actggatagc agaaacggaa tgggcatgcc ttctgaggac 412441 gatatcatcg gtactgaatc tctcgtcttt tatccattcg gtgagatgag acaggcaaaa 412501 taaaatgcaa tgcaaaaaga acatggaaca tgacggcacc gataataaag cgccgtgcac 412561 gtttaaaaaa atgatgatga aacggtgcgg agccggcttt ccgccccgtt ttttatgata 412621 gaaagcgttt tgaagaaaag ggccctgttg aaataaacag aatcaggatt ggcgaagccg 412681 tgaagcgcat cgaattggta aatctcaaga tgggtatgct gtttttcccg cagttttttg 412741 ataagaagcg ctacgtcaaa cgacggctca taattaggga aaaacaatag gaccgggcag 412801 gctggcatgt gatgaagaga gtcgcgtatc cgggaaccgt aataacaaac cgatccgctc 412861 acctcaggca tactgctgca tttccatgcg atagtagccc ccacgctgaa tccaatcaca 412921 aagatgtgcc gtccggcgtt ttgcctgatc acattctgga tgatggtttc tcccgttttc 412981 agcctttcgt gttttgtaaa ttgttcgtat gccgtttttt cttctttcag tgtgtagact 413041 tcatcctcgc cgagcaggtt gggcgtcaac acatcatatc cagccatttt gatcagccgg 413101 cccatctttt tcatatggct gtttacacca tatatttcgt gtgcgagaat gacaagcggt 413161 tttgggaaca taacggcctc cttttgtgtt ttttccatta tatcctatcg tttcacttta 413221 ggctgagata taatggtcaa aaaaaggaga tataaaatga actcattatc tttgcctcac 413281 cgctatccat ttttgtttat tgatggcgtg acggatagcg agcccggcaa acatgcggca 413341 gcttataagc tgattagtga gaacgactgg tttatcactg atacgcaaac agaaatgccg 413401 ttttcacttg tgattgaagc gcttgcgcaa accgcggctt ttacaggaat tacagatgag 413461 aacagcttgg gattattgtc ttcggtgaag aaagcggaaa agctgggaga agctgtgcct 413521 ggtgaccggc ttgatcttac gtttgaagtc acgcgcaatc ggcgcgggtt tgtgttcgga 413581 catgccaagg catcagttgg agagcagcct gttgctgaag ctgaaatcgg catctatatt 413641 gaaaaatgaa aaaaaccctt cacaacattt tgtgaggggt tctattttgt gtcgtaatcc 413701 cgttcgcttt gagagttatc tctttgctgg cgtttgtgtt tttcatcatt catattttcc 413761 ttcagctctt cattaggaat cggatcggtt aagtcgttgt gctcggggtt ttcatttggt 413821 ttgttttgct gttttttttc tgtcatgttt gatcacctca ccgtttgttt tcctcttatt 413881 cattctcctc aaacatagga aatcgctttt ttgtcccgct gggtataatg tattagaata 413941 gagagaagca caacaaaaag ataaagagag gtacatatat gtctgttcaa agagaagatg 414001 tagatatcaa gctgatcgca attgatatgg atggtacact gctgaacgac gagcagctga 414061 tctcggatga aaaccgcaaa gccattcgtg aagcggagga taaaggtgtg tatgtggtga 414121 tcagcacggg ccggacgctg atgacgtgca gggagctggc ggaatcgcta aagctgtcat 414181 cctttctaat cacggcaaac ggcagtgaaa tttgggattc gaattttaat ttggtggaac 414241 ggaagctgct tcatacggac catattcaaa tgatgtggga tttgcggaat aagcacaaca 414301 ctaatttctg ggcttctacg gtgaataaag tatggagagg cgagtttccg gaaaacatta 414361 cggatcatga atggctcaaa ttcggctttg acatcgagga tgacgatatc cgaaacgaag 414421 tgcttgagga gctgagaaaa aacaaagagc tcgaaatcac aaattcaagt ccgacaaaca 414481 ttgaagtcaa cgcgcttggc atcaacaaag ctgcagccct tgccaaggtt acggaaaaac 414541 tcggctttac aatggagaat gtgatggcga tgggcgacag ccttaatgac attgcgatga 414601 tcaaagaagc gggtcttggc gtcgcaatgg gcaatgcgca agacatcgta aaagaaacgg 414661 ctgattatat cacggataca aatattgagg atggtgtcgc taaagcgatt cgccattggg 414721 tactataaaa aaagagagtc ctaagatgga ctctcttttt tagtttggca ggttttattc 414781 tgggaccatg gtaggttttc tgacaaaagt atttcacaaa ctgatatgat tcacttataa 414841 tgaaataaag ttcaaaaatt cggaatagtc gttccgaatt tcgggacaat aaatgacata 414901 aagcatatcg tttgctttgg caggagggat tctgtgtttc agattgattt aaactgtgat 414961 ttaggagaaa gcttcggagc ctacaagata ggccttgacc aagatatttt agagtatgtg 415021 acatcagcga atatcgcatg cggatttcat gcaggagatc ctagtgttat gcgaaaaacc 415081 gtcgcgcttg cagcagaaag aggcgtgaaa atgggtgcgc atccgggctt gccggattta 415141 ctcggttttg ggcgccgcaa tatggcgatt tctcctgagg aagcgtatga tcttgtcgtt 415201 tatcaaattg gcgcgctctc tggctttcta aaagcagagg gacttcacat gcagcacgtc 415261 aagccgcatg gcgctttata caatatggcg gcagtcgatc aaaaactgtc ggatgctatc 415321 gcgaaagctg tctataaggt tgatcccggc ctgattcttt tcggtcttgc tgagagcgag 415381 cttgtaaaag cgggagaacg gatcggactt cagaccgcaa atgaagtgtt cgccgacaga 415441 acataccaat cggacggcac gctgacaccg cgctcccagc cggacgcact cattgaaagt 415501 gatgatgccg ccgtcaccca ggtcatcaaa atggtgaaag aaggggcggt caaatctcag 415561 caaggacatg atgtgtcatt aaaagcagat acagtctgca ttcatggaga tggagcccat 415621 gcgctgacat ttgcgcaaaa aatcagaaaa cagctcaaag cggctggaat tgaagtgaca 415681 gctatttcag aacagaggtc aacataaagg aggaacaata gatggagcag cagaaaaaga 415741 cagcaggaaa aaaagcgggc agctggtcat tgctgatggg cgccgccttt ttaatggcga 415801 catcagcaat cggaccgggt ttcctcaccc aaaccgcaac attcacaaac acactcgcag 415861 caagcttcgg ttttgtcatc ttaatctcta ttattttaga tattttcgcc caaaccaatg 415921 tgtggcgcat catcgcagtt tctggaaaac gaggtcagga aattgcgaat atggtgcttc 415981 ccggactggg gtatttcatc gccattctcg tcgtgcttgg cggactagct tttaatattg 416041 ggaatatcgg aggggccggg ctgggacttc aggtgctgtt cggcattaca cctgaaacag 416101 gcgctttaat cagtgccgtt atcgccattt tgatttttgt catcaaggaa gcaggaaaag 416161 cgatggaccg ttttacgcaa atcgcggggt tcgtgatgat tattttaacg gtctacgttg 416221 cggcgacgac agctcctccg gtcggacagg cagtcgcaaa tacattcgtc ccggaacaca 416281 tcagcatatt tgccattgtc accctagtgg gcggaaccgt cggcggttat atcacatttg 416341 ccggaggaca ccgtttgctt gatgccggaa ttaaaggaaa ggaatccatt ccgcaggtga 416401 caaagagctc ggttgtcggc attttaatta catctgtcat gcgtatcgct ctttttcttg 416461 cggttctagg cgttgtatcg aaaggcctgc acatcgatga aagcaacccg gcggcttctg 416521 tcttcaagct ggctgctgga aatgtcggtt ataaaatttt cggattgatc atgtggtctg 416581 cggcgattac gtctgttatt ggagcagcct atacatctgt ttcatttttt aaaacctttt 416641 ctccaaaaat tgaaaagaat tcacgcggta ttattatcgg atttattgtg gtttctacgt 416701 tagcttttgt cacaatcggc cagcctgcga agatcctcgt ccttgtcggt tcactgaacg 416761 gcttaattct gccgattgcg ctcggaacgc tgcttgttgc cgcctacaag aaaaacattg 416821 tcggtgatta taagcatccg ctttggctga caagcacagg cgcgcttgta gtgattgtaa 416881 tggcagttat gggaatctac acgttatgta cacaacttcc tcaattgtgg agctgatata 416941 agtggagcaa ttaaacaaaa tggcgccaaa ggatgtacgc gccctgatac gagaggggaa 417001 aataaacggg ccgaccgcag gcatgtccgg cggctacgcc caagcgaatc ttgtggtttt 417061 gaaaaaggac cttgcgtttg attttctgct gttttgccag cgaaatcaaa agccctgccc 417121 cgtgctggat gtgactgaag caggttcgcc tgtgccgtct ctggctgcgc cggatgctga 417181 tatcagaacg gactttccga aataccgtat ttacaggcac ggtatcctaa cggaagaagt 417241 atctgatatt acgccatact gggaggacga ttttgtcggc tttctgatcg gatgcagttt 417301 ctcctttgaa caggcactga tcaataatgg gatagctgtc cggcatattg atgaggggac 417361 aaacgtctca atgtataaaa cgaatatcga ttgtgttccg gcgggggcgt ttcacggaca 417421 gatggttgtc agcatgaggc cggttcctga acggctggct gtacgtgctg cacaagtgac 417481 ctcgcgtttt ccggctgtgc acggagggcc gatccatatt ggcaatccgg gagcaatcgg 417541 gattcgcgat ctcgggaaac cggatttcgg agatgccgtt tccattcgtg acggcgaggt 417601 tcctgttttt tgggcatgcg gagtgacccc gcaagccgtg gctatgaatg taaagcctga 417661 aatggtcatc acacatgcgc cggggcatat gctcatcaca gatattcgag acgagtcgct 417721 tgcggtgctg tagcctctcg tcatcctgat gaacgagaat taaaagaggt gagaaagatg 417781 actgtacgat atcaaatcga acagctcggt gattctgcaa tgatgatccg attcggagaa 417841 gaaatcaatg aacaggtcaa cggcattgtc catgcagcgg ccgcttatat agaagaacag 417901 ccatttccgg gattcattga atgtatcccg gcttttacaa gtctaaccgt attttatgat 417961 atgtatgaag tgtacaagca tttgcctcaa ggcataagct caccttttga gagtgtcaag 418021 cgcgatgtcg aagagcggct ggcagaaata gccgaagact atgaggtcaa ccgccgtatt 418081 gtagaaattc ccgtttgcta tggcggtgaa ttcggtccgg atttagaaga ggtggcgaag 418141 atcaatcaac tgtcaccgga ggaagtaatc gacattcata caaacggtga atatgtggtg 418201 tatatgcttg gcttcgcgcc cggttttcct tttctaggcg ggatgtcaaa acgcattgca 418261 gctccgagaa aatcatcgcc aagaccgtcg attcccgcag gttcggtcgg tattgcggga 418321 ttgcagacag gcgtttatcc gatttcaacg ccgggcggct ggcagctgat cggcaaaacg 418381 ccgctggctc ttttccggcc gcaggaaaac ccgccgacat tgctgcgggc gggagatatt 418441 gtgaaattcg ttcgcatctc agaaaaagac tatcacgcct ataaggagga gtccaattga 418501 gcatgaaagt attaaagccc ggactgctca caacggttca ggatataggc agaacgggtt 418561 accaaaaata cggcgttctg gccagcggcg ctatggacac ggtttcactg cgcattgcca 418621 atctgttgat aggaaacggc gaaaatgaag caggtctcga aataacgatg atggggcccg 418681 gtccgtcgtt tcatttttca aaacagacac tgattgctgt gacaggggcg gacttcacgc 418741 tgcgtattaa tgacgaggaa gcgcctttat ggaagcctgt gctcatcaag gaaaacagca 418801 cggtcagctt tggcccctgc aaactcggca gccgtgctta tttggcggca gctggcggca 418861 ttgaggtgcc tgccgtcatg gaaagtaaaa gcacatacgt cagaggaagc attggcggac 418921 ttcatggcag agcgcttcaa aaagaagatg aactgaacat tggagagatg tcagctcttt 418981 cgcaaaccat cctttctcgc ttaagttcgc agcttggaaa acagggattt gcagcaccga 419041 agtggtcagt cagccgcggc agatttctgc cattgaagaa gaatcccgtc attcgggtgc 419101 tggaaggaaa gcaatttgcc tttttcacag aagaatcaaa aacgcgtttt tatgaagaag 419161 catttcgtgt cacgccgcag tccgaccgta tgggctacag gctcaaagga gaaccgctcg 419221 aactgaaggc cccgcttgag atggtgtcgg aagcggtttc attcggaaca gttcaggtgc 419281 cgcctgacgg caacccgatt atcctgcttg cagaccggca gacgactggc ggctatccga 419341 ggatcgcgca catcatatcc gctgatcttc cgattgtttc ccaaatcatg ccgggcgagc 419401 acgttcagtt tgagcctgtg tccctccagg aggcagaagc gcttgcggta gaacgggaac 419461 agcatataaa agaactgaaa acgagaatga agatggaatg gctgacatag caaaggggat 419521 gaatgatgca gaataaaaat aaaaccgtag tcaaatctat ggcgctgctt aatttgtttt 419581 tgcataaacc aagcctaacc ttaagtgaac tggtgtcgct gacgggaatg ccgaagacct 419641 ctgttcaccg gatggtcagc tccttggagg aaatggggtt cctcagtcgg gatgcgtccg 419701 gcgcttattc gctgggattg gtgtttttgg aattcggaca gcttgtcgct gacaggctgg 419761 atatcagaaa aatagcgaaa ccggtgatgg aagagctgtg ccgggaagtg gatgaggccg 419821 tgcagttgat catgagggac ggcaatgaag cgatatacgt tgagaaaata gaagggacac 419881 agactgtgcg gctgtatacg gcgatcggca ggcgttcccc cctatacgcg ggagcgtgcg 419941 ccagaagcat tctgtccttt cttccccgtg aagaaatcga agcatacatc aaacaaaccg 420001 agctcatttc gattggctcc ggaacgatta ccgatcccga aaaactgctt caggagattg 420061 atgcctctgt gcaaaatggc tatactgtca gctattcaga gctcgaaaac tatacggcgg 420121 cgatcggcgc cccgatcttt aaccatgagc gccaggtggc agccggcatt agcattgcag 420181 gctttgaagc gagatttaca gaagacaggc tgccctattt aacagaaaag gtgaaggacg 420241 ccgctttaca gatttcaaga aaaataggat atacataagt agccaatctt ttctctgctg 420301 cgtacattaa cgtatcgacg ttcaagagtg gaggaaagaa catggtgctt cgatatacag 420361 ctctgggcga ttccttgacg acagggagag gctccgggct gttttcaccc ggcttcgtcc 420421 agcgttttgg ggacatgatg gaagctgact tgaaaacaag aacggcaata aacatatttg 420481 ccagatcagg tctgaataca gaagagattt tgggactcct gtcatatccc tatgtgcaaa 420541 aatgtattcg agatgctgat atgataacga tcacagggtg cggaaacgat ctcatcgatt 420601 cggtcttagc ctaccaaacc tctaaggatg aaacgatttt cagccgtgta tccgcccatt 420661 gccatgagaa ttttgaaaag atgattgcca aagtcgccga gattaaagga gaaaatcctt 420721 ccccgtacgc cattcgtgtg ttcaacttat acaatccgtt tcccgaaatt gatatcgccg 420781 gcaaatggat cacttcgttt aattcacatt tagaaacact tgcatcagca ccccatgtca 420841 aaatcgcgga tgcctatagc atcttcaaag gcaaagaaca ggaatatctg tcctttgacg 420901 gtgtccatcc gaacagcaaa ggctatcaag cgatggctga agccgttcac aagctaggct 420961 ataaagaatt atcagtttca tagaaaacgc gcctcatgac aggcgcgttt tttatgtgtg 421021 atcgaaatat taaaagaaac ttaaaattct ctgtcttctg ttctacagac aaacaaagtg 421081 cgctagaata atggagggcg taggcaaata tagccataac gttcaatatt tcgtatataa 421141 ggaaggatgg tccttttgtt tcggattttt aaaatgtctt ttgcggttat cattattata 421201 ctggcgctta ttgcttttaa ctatacggaa cacacctctg taatccaatc ggtcatgctc 421261 gtctttcttg gtgcggtcat gtttatgcag gggcttgaag agcgcaaaaa agaaaatgac 421321 ggctcaggcg cttttaatat ttataccgcc gtttttgtat ggtctgtctc ccttatcggt 421381 tttacacttc atattatata aatctattac acatcctgaa aatgctcgac cgtcgggaac 421441 ggggtataga accgatgaag caaggctttc cactcttgat actctgaaga accgcgaaag 421501 ccttccgtat ggtcctcaag tgtttcccac tccacaagaa gcagatattt atgcgtttcc 421561 tccatgcatt ttgataacga gtgagtgata tagcccttca tgccggaaat aatcggcgca 421621 gcttgccgga atgcatcctc aaactcttgt tcaaggcctt ctttaatgtg aagcattgct 421681 gcctctctga ccatgctatc ccttctttct gtcttttcaa atagtctaca gcaaacgata 421741 ggagatttct gcaaaatcgg tgaacttttc cttcattttc aaaaaaatct tgcacgcacc 421801 aattcaatta agagaaaata acaagtggaa ggcaggggaa agtcatgtta aaaaagtgta 421861 ttctactagt atttctatgc gtcggattga ttgggttaat cggatgctcc aaaacagatt 421921 caccagagga tcgcatggaa gcattcgtga aacagtggaa cgatcagcaa ttcgatgaca 421981 tgtatcaaag cctgactaaa gatgtcaaaa aagaaatctc caaaaaagat ttcgtcaaca 422041 ggtataaagc catctatgag caggccggcg taaaaaattt gaaagtcact gcgggagaag 422101 tagataagga cgatcaagac aacaagacga tgaaacatat cccgtataaa gtcagcatga 422161 acacaaatgc cggcaaagtc agcttcaaga atactgctgt gctgaaatta gaaaaaacag 422221 atgacgagga gtcatggaat atagattggg acccatcgtt tattttcaag cagctggctg 422281 acgacaaaac cgtgcaaatt atgagcattg aaccgaaacg aggccaaatt tacgataaaa 422341 atggaaaagg cttagccgtc aatacagatg ttccggaaat tggaattgtt cccggagagc 422401 ttggcgataa aaaagagaaa gtcataaaag aactcgccaa aaaacttgat ttgactgaag 422461 acgacatcaa gaaaaagctg gatcaaggct gggtaaaaga cgattcgttt gtgccgctca 422521 aaaaggtcaa gcctgaccag gagaaattag tttctgaagc gacgtcatta caaggcgtaa 422581 caagaacgaa tgtcagctcc cgctactatc cgtatggcga aaagacagcc catttgacag 422641 gctatgtccg cgccattaca gcggaagaac tgaagaaaaa gaaagaagga acgtacagcg 422701 atacgtctaa catcggtatc gccggacttg aaaatgtgta tgaagacaag ctaagaggca 422761 caactggctg gaaaatctac gtgccgcaaa ccggggaagt catcgctgaa aagaaagcaa 422821 aggacggcga ggatcttcac ctcacaattg atatcaaaac gcaaatgaag ctgtatgatg 422881 aactgaagga tgacagcggg gcggcagtcg cgctgcagcc gaagacaggc gaaacactcg 422941 cccttgtcag cgcgccttcc tacgatccaa acggatttat tttcggctgg agcgataagg 423001 aatggaaaaa gctaaacaaa gataaaaaca atccgttttc agcgaaattc aataagacat 423061 acgcgccagg ttctaccatt aaaccgattg cggctgctat tggaatcaaa aacggcaccc 423121 ttaaagccga tgagaagaaa acaatcaaag gcaaggagtg gcaaaaagat tcaagctggg 423181 gcggctattc agtgacacgt gtgtctgaga gacttcaaca agtcgatttg gaaaacgccc 423241 ttattacgtc agacaatatt tattttgccc agaatgcgct tgatatggga gcggacacct 423301 ttacaaaagg cttgaagaca ttcggttttt cagaggacgt tccgtacgaa ttcccgatcc 423361 agaaatcgtc tattgcaaat gacaagcttg attcagacat tttgcttgcg gatacaggct 423421 acggacaagg gcaaatgcaa atgtctccgc ttcacttggc aactgcttac acgccatttg 423481 ttgacaatgg agaccttgtc aaaccgacgc tgatcaaaaa agattcacaa acagctgatg 423541 tttggcacaa gcaagtggtc acgaaggaag gagcggcaga cattacaaaa ggtctgaaag 423601 gcgttgtgga agatgagcgc ggatcagcgt atcagcctgt cgtgaaagga atcacagtgg 423661 ctggaaaaac aggaacagcc gagctgaaaa catcaaaaga tgataaagac ggcacggaaa 423721 atggctggtt tgtcggctac gattacgaaa acaaagacct gcttgtcgcc atgatgatcc 423781 aaaatgtgca ggaccgcggc ggcagccact atgtcgttga gaaagcgaaa aagcaatttc 423841 aatcgaatta aaatgtcttt ttaaaaggag cgaaaggaaa aaggggatct gaggccgaat 423901 gaactagtaa gggggcaaaa cccggtttat acaaagaaaa gagggatttt gcatgcagcg 423961 tattcaattg gcggaggatc ttcaattttc aagagtcata cacgggcttt ggcggctgaa 424021 tgaatggaac tattcagatg ctgaacttct aagcctcatt gaatggtgta tcgatcacgg 424081 catcacgacc tttgatcatg cggatattta tggaggctat acgtgcgaaa agctgtttgg 424141 aaacgccctt gccctttcgc ctggattaag agaaaacata gagttggtca caaaatgcgg 424201 tatcgttctt gaatcgcctg aacggcccgc tcacagatcg catcattata acacaagcaa 424261 atcgcatatt ttggcatccg ttgagcaatc gcttatgaac cttaggacgg attatatcga 424321 tatgcttttg attcacagac cggacccgct catggatccg gagggggtag cagaggcgtt 424381 tcaggccttg aaatgctctg gcaaggtcag gtactttggc gtttcaaatt ttaaagatca 424441 ccagtatcgg atgctggaat catatttgcc tgagaagctc gtaaccaacc agattgagct 424501 ttccgcatac gaattagaaa atatgctcga cggcactttg aacctgtgcc aggaaaaacg 424561 gattccgccg atggcttggt cgcctctggc aggcggcaaa gtattcactg aaaacacgga 424621 taaagaccga cgtgtccgta cggcgcttga atccgtccaa ggggaaatcg gcgccgcttc 424681 attggacgag gtgatgtacg catggctgta tacgcatccg gccggcatca tgccgattgt 424741 cggaagcgga aagcgcgagc ggatttccgc cgcgataaat gcgttgtcat acaagcttga 424801 ccaggatcaa tggttccgca tttttacagc cgtacagggt tacgatattc cataaaaagc 424861 atcagtttac cagctgatgc tttttcaata ttgtcacacc gcttagtgcc aaattaccat 424921 ttataagtga ttgattcttt cttgaaagcg ttttatatta aaaggaaacc tctctatatc 424981 ctctactgca tctccttgcg acttcatccg cacatcaaga ttggctagga ggtctttttt 425041 atgtatatga ctgccagaga acaaaagctg ttaaagcact tattattaca aaacagatat 425101 ataaccgtaa ctgagcttgc tgagctgatg caagtcagca cgagaaccat tcacagggaa 425161 ctcaaatcaa ttaaaccgct gatggaaacc gtggggctta cgttagataa acagcccggt 425221 aaagggttga aagcagtggg aagtcccgag ggtaaacaaa agctgcttac tgatttatca 425281 tatgaacagc atgaatacag cgccgacgaa cggaaactgc tcattctttg ttcgttatta 425341 gagtctcagg agcccgtcaa actgtacacg cttgctcatg atctccaggt gacgaatgcc 425401 acggtcagct atgacttaga tgagctcgag aagtggattt ctccctttgg actgacactg 425461 atccgcaaaa gaggttttgg catccagctc atagggccgg agaatgcgaa acggaaaatt 425521 gtcggcaact tgattgtgaa ccgtctcgac atccaaatgt ttttggaagc ggttgaatta 425581 aacatcaaag gaaaaaccga ttcttcagag aaaatgttcg gggttgtcag caaaggtgag 425641 ctgttaaaaa tggagcgcat cttatttcag ctcaaagaaa aaatcgcttt ttcattgtcc 425701 gacagctcct atatagcgct cgtcgtccat ctgacgtatg cgatcgaacg aattaagctt 425761 ggggaaacta tcaccatgga gcaaaatgag cttgaggaac tgatgaatgc gaaggaatac 425821 agctccgctc ttgaaatcgc gggcgagctt gaacgtgcct tcggcgtgac gattccagag 425881 gcggaggtcg gctatattac aatccatctt cgaagcgcca atcgaaaata caaaacagaa 425941 tacaaagcgc aggaaattga gctggaaaca gccctgcaaa caaagcggct cattgctttt 426001 atttcagaca aaatcagaat ggatctgacg aaaaactact ctttatatga aggcttgatt 426061 gcccatttgg agccggccgt cagccgcata aaagaaaata ttgagatata caatccgatg 426121 aaggaacaga tcaagcgcga ttattttctg ctttatatgg cgatcgaaga aggtgtcgaa 426181 aagtattttc cgggcatgtc cttttctgat gatgaaatcg cttttatcgt tcttcacttt 426241 ggctcggctc ttgaaatcaa aaaagaagaa gcaaaagtga aagcgcttgt cgtctgctca 426301 agcgggatcg gctcctcgaa aatgcttgcc tccagactga aaaaagagct gccggaaatt 426361 gaatcgtttg atatgtcatc tctgatcgag ctaaagggga aggatgttca agcctatgat 426421 atgattgtgt ccactgtacc gattccttat gaaaacattg attacatcat ggtcagccca 426481 ctattaaatg aggaagacgc aaaccaggtc aagcagtata tcaagcggaa gattcccctt 426541 attcttaaca aaaaaagaag ctcgaaggaa gaggcgcagc aagctgatgt acctgacatg 426601 ctggaggcgg cggaaagcat agggcggtat atggaagtta tccaagatgt tctgcgccat 426661 tttacgctag ctcaactcaa aacaaacccg gaccatagca tgcttctgct agagcttttt 426721 caacagctga agaaggatgg cctgatccgt gatccggaaa aagccgcggt ttgcctggct 426781 gagcgggaga aacaaggggg attgggaatc cccggaacaa acatggcgct ttatcatctc 426841 aaaaatgatg aaatcgtcct gccttttttc aaaatgtttg atctcagcac cccctatgaa 426901 gtggatggca tggacggaaa taccctcagg atgacacgca ttctcgtcat gatggcgcct 426961 ggctcattat ctgctgaagg ctcggagatt ttaagcgcga tcagctcggc aattatcgag 427021 agcggagaaa gcatggcggg gtttcaggaa gaaggaggac aagaattgta tcagcggtta 427081 aaccgcatat ttttcacatg gatgaaagaa aaaaacatac tgtaaacctg catggcacac 427141 gtcaaaaatt tggcgtgtgt ttttctgtgg atggggaaca aaataagaaa atgtgggact 427201 attttatcat tcagtattgg aataattcca aaatgaaata gttttacaag ttatcttttt 427261 tgggttaaaa tgggtgaggt aaggaagaaa atctaacaaa ttattgaaga ttcaagagaa 427321 tataggagat gacgatatgg aaacattaca gcatctgatt ctgcatgaca tgccgaatag 427381 cgaagaaata gaggctgtaa aaagcggaga ccatacactg acatataaag gttaccgtaa 427441 acggattaat cagctggcga atgccatgct tcaaaaagga attcaaaagg gcgaccgtgt 427501 tgcattgctt tgcaaaaacg gccatcccgc ctcaactgtt atgttcgccg cacttgaaat 427561 aggtgctgtt gtcgtacctg tcagctggca gctgaaacca tatgaaatga caggcatttt 427621 aaaagcaagt gaaccaaaag cgatgtttta cggagcggag tttaaagaga tactggatga 427681 agttcttcct gaattgtcct cactgtgtgt aacaatggaa acaggaacag cttacgaaac 427741 atctgctgaa tttgaagcgc tgtttgcagg tcctgatcat ttgccagaga cggaaatggt 427801 ttcacctgat gatacagcac ttctgatgtt tacatctgga acaacgggaa acccgaaaag 427861 atgcatgatt acacatggcg gcatatacag atacgttaaa aaatccaaca gctcaatagc 427921 acgtatgaag ggccttcgtt ttctcgcgtg ccatccgatt tatcatacga gtgcgctcat 427981 ttgcatcatg cttggaacgt ttgcagaaac aacatttgtg tttacaaagg atcaagatcc 428041 tgttcacatg ctgaaggtca ttgaagaaga gaagattcag accgtgatgg ctcttcctgt 428101 gttctacacg tatttgcttg aggcgtggga aaagcaccaa actgacttat cttcgcttgt 428161 tattttaatg acaggcggaa caaaagtgcc gagcagccta ataagccgct atcttgatat 428221 tggcattccg cttgcgcatg gctatggaag tactgaggct tggggcatca gcacatggac 428281 gcctgatatg ggaatggata aagcggcatc tgcaggaaaa cctgtggcag gtgttaaagt 428341 caaagtggaa gatcctctga ccggagaaga acttcctcaa ggagaaatcg gcgaaatcgt 428401 tgttcatact ccattcttat ttaaaggcta tgaagacaat cctgaagcaa cagcgaaagt 428461 gctgcaaaat ggatggttta gaaccggaga ttcaggatat gtagatgaag atggctttat 428521 tttcatcacg ggacgctaca aggatgtcat tatttacgga ggcgataacg tctatcctga 428581 tcaggttgaa gaagttatcc agcagatccc gggaatcctt gaaacggctg tggtcggtat 428641 tcctgacccg ctttacggtg aaaaaccgaa agcttttatc gtgaaaaatg gcggccagcg 428701 catcacggaa gaggatgtca tcgcattttg taaagaacgc ctgtccgctt acaaaatacc 428761 tgaagttgaa tttgttaacg aactgccgaa aaacaacctt ggcaaggtga aaaaagacgt 428821 cctgcgcaat caggctgtac attcataaaa gaagaagccc gtccacttta tgtggcgggc 428881 ttctttgcag ttgcacagac ggaaagctca ggcttaatgt tcttaaattg tatatcaatg 428941 tcttcgaagc cggctgcttt aaagtcagca atcatctgtc ttccaaatga tttggttttc 429001 tcaggactgg catccgcttc ccgcggctgc atcgtaatgg ctgctttgcc gcctggcttt 429061 aatgcccgat aaatctgttt tatgcctttt gtttggtcat tccaaatggt gtagttgtta 429121 acggaaatca ctttatcata aaacgaggcg gggagaggaa atgtctcgat gcttccttgt 429181 atcaggcgta cgccctttgg tttcactctg cgggcggcca gcttcagcat ggcctctgat 429241 acatcaatcc catgaagatg aacatccttc tcgcgtttca gcatctgctg catgcagtat 429301 cccgggccaa acccgacttc taaaatgctg tccccgcgcg tgatacccag ctgattgatt 429361 gtccactgat tcagtgtttg attttcagca gccatgatgt acccggcaat catgccgatg 429421 acgccctttg gcctgctgaa tcttctagaa agcatgttaa tcattcagca accaaccccc 429481 tttttgagtt aatttcctct cagcgttcca tgtgaaacat ttttctgata aagcaatgcg 429541 aaggtgccaa gccatgttta tccaaagagt gtgtgaggta cacaacaaat agacatgaaa 429601 acaaaggagg agaatcatca tggcaaatta tccaaaagaa ctgccggcac aaactcaaag 429661 tcgccagccg ggaattgaaa gcgaaatgaa tccaagtccg gtgtatgagt acgaggatta 429721 taaaggagca gacaaattaa aaggaaaagt agctcttatt acaggcggcg acagcgggat 429781 cggacgcgcg gtttccgtcg cttacgcaaa ggaaggcgca gacatcgcca ttgtgtataa 429841 ggatgagcat gaagacgctg aggagacgaa gaaacgtgtt gaacaagaag gcgtaaaatg 429901 cctgctgatt gctggtgacg taggtgaaga ggaattctgc aatgaagcgg ttgaaaaaac 429961 ggtcaaggaa ctaggcggcc ttgacatcct tgtcaacaat gcaggtgaac agcacccgaa 430021 ggaaagcatc aaagatatta cgagcgaaca gcttcaccgc acattcaaaa caaattttta 430081 ttctcaattt tatttgacta aaaaagcaat tgattacctg aaaccgggca gcgccatcat 430141 caatacgaca tccatcaacc cgtacgtagg gaacccgaca ctgattgatt atacagcgac 430201 aaaaggggcg atcaatgcct ttacaagaac aatggcgcag gcgcttgtca aagacggcat 430261 ccgtgtaaat gcagtcgcgc cgggtccaat ttggacgcca ctaatcccag ctacgttccc 430321 tgaagaaaca gttgctcaat ttgggcaaga tacgccgatg ggccgtcctg gacagcctgt 430381 tgagcacgtc ggctgttatg tgcttctggc atcagatgag tcctcttaca tgacaggtca 430441 gaccctgcat gtcaacggcg gaaactttgt gacgacataa gagggagtga gacatatggg 430501 catcacgaaa gaagaagtga acagctacta tcaaaaagca gggattgtat taacggacga 430561 ggaagtagac caaatccagc tgatggatta cggcttagga aaagaaagaa aagtcgggct 430621 ccagctcttc gtctacgtca atacagaccg ttattgttca aaggaattgg tgctgtttcc 430681 gggacagact tgcccggaac accgccatcc accggtcgac ggccaggaag gcaagcagga 430741 gaccttccgc tgccgctacg gaaaagtgta tctttacgta gaaggagaaa aaacgccgct 430801 tccaaaagtt ctccctcctc aggaagacag agaacactat acggtctggc acgaaattga 430861 gctagaaccg ggcgggcaat acacgattcc accaaacaca aagcattggt tccaggccgg 430921 ggaagaaggt gccgtcgtga cggaaatgtc atcgacgagc acggataaac atgatatctt 430981 taccgatcca agaatataag gatgggctta acagcccatc ctttttgtat tgaaaaaaac 431041 agaatcatcg ctataatggg taaaaaagga aagagggcga ggcaatgttc acttgcaagg 431101 taaatgagca catcaccatc cgattattgg agccgaagga tgcggagcgg ctggccgaac 431161 tcattatcca aaatcagcag cggcttggca agtggctgtt ttttgcggaa aatccaagca 431221 gcgctgacac gtaccgagaa acaatcattc cagattggcg gcgccagtat gccgacctga 431281 acggcattga ggcgggtctc ctttatgacg gcagcctatg cggcatgatc agcctgcata 431341 accttgatca agtgaatcgt aaggcggaaa tcggatattg gattgccaaa gaatttgaag 431401 ggaaaggcat tattacagct gcctgccgaa aactcattac gtatgctttt gaagagcttg 431461 agctgaatcg tgtggcgatc tgtgcggctg tcggaaacga aaaaagcaga gcggttccgg 431521 agcggatcgg gtttctagag gaaggaaagg cacgggatgg cttatacgta aacggcatgc 431581 atcacgacct cgtctactac agtctgttaa agcgtgaatg ggaaggcgaa aaataaagag 431641 cacactttct tgtttaaatc ttccccggat gtggaaaagt aacagcggag acgttaaaaa 431701 ggagtgattc gagatgaatc agcaagacat taaacaaaaa gtgcttgatg ttctagatca 431761 ccataaagta ggttcgctcg caacagttca aaagggcaaa ccgcattccc gctacatgac 431821 ttttttccat gacgggctga cgatttacac accgacaagc aaggaaactc ataaagcgga 431881 agaaattgag aacaacccca atgtccacat tttattaggc tatgattgtg aaggttttgg 431941 cgacgcatat gtcgaagttg ccggaaaagc aaagatcaac aattcggcag aactcaagga 432001 caaaatatgg agttccaaat tagagcgctg gtttgacggc aaggatgatc cgaatctggt 432061 gattcttgaa attgaaccgg aggatatcag attaatgaat gccggggaga aaacaccggt 432121 ctcactcgaa ctataaaaaa tttgtgtttt caggggcgat atgttattat gaatagctag 432181 taagaaaaat aagcaaataa aaaagaaagt aaacttcttt tttctgtttt gagagagaag 432241 cttaccgctt cccaagcagc ataaccagct gcccttattc ttttccttca taacaaatcg 432301 cccctaacga tgagatggaa aaaagacttt tttgttttac aattcacacc ggcgcggctt 432361 cggagccgca gtgacgattg agaggtaggg ctttcgttgt cttgtgttca agaaatttcc 432421 atggtgttta ctttccagaa tgattcttcg gaacaatgct ttatgaatct aacccgcctg 432481 acttggcgga tgatataatc tttatttgcg tatagaaaag aataagacaa accgcccggc 432541 gtacgccgga cggttttttt attgcaaaaa acacatcgta ctgaaacctc cttgtcttct 432601 ttccagtctt atctctagga tgaaattgga ggaagaataa cgtgcatgtc attacaacac 432661 aagtactttt tattttttgt tttttattgc tgattcactc gatagaaacc ttagcctatg 432721 cgacaaggct ttccggagct cgcgttggat ttattgcgtc cgcgctttct ctgtttaatg 432781 tcatggtcat cgtatccaga atgtcgaata tggtgcagca gccctttact gggcatttaa 432841 ttgatgatgc tggaaaaaac gcactggcga ttgtagggga gcagttccgc tttttaattt 432901 tcggatcgac agtcggcacc attttgggca ttatcctgct cccgtctttt gtcgctcttt 432961 tttcacgggc gattattcac ttggcgggcg gcggcggctc cgtttttcaa gtattccgaa 433021 agggattctc gaaacaagga ttcaaaaatg ccctttccta tttgcgtctg ccgtccattt 433081 catatgtaaa aggatttcat atgcgcttga ttccgaagcg tttgtttgtc atcaacatgc 433141 tgatcacatc gatttatacg attggtgtgc tttcggcttt atacgcaggc cttttggcgc 433201 cggagcgcag cacgacagcc gtcatggctt cgggtttgat caacggaatt gcaacgatgc 433261 tgctggctat ttttgttgat cctaaggtat ccgttcttgc tgatgatgtg gcaaaaggaa 433321 aacgaagcta tatctattta aaatggacct ctgtcacaat ggtcacatca agggtggcgg 433381 gcacactcct cgcccagctc atgtttattc ccggggccta ctatatcgcg tggctgacaa 433441 agtggtttta ataagaaagg ctggatcata aagatccagc ctttttgcgc ttccttattt 433501 atagttcctt aatccgcggt cgtacaaaaa atttccgaat gggacgaaag cggcgatgaa 433561 gccggcagct gaccatttca gcggccattt gacagagaag gttgcataag ccaagacaag 433621 caaatacaaa atgaacaacc cgccgtgaac cgaaccgaca attgtcaccg caagcggaag 433681 gcctgcccaa tatttaagcg gcatagcgat gaacaacagg attaagagtg acattccttc 433741 aataaaaccc atcgtgcgaa gtcttccgat cggcgtgtgc agcataaatc gccctccttg 433801 tggacacgtt ttcattttat actataaaca atccgggggg gcatatgaca gctttcaaaa 433861 aatgttcgga aaacattcat ttttacatgc cttttctagg gaactgtact tgtcatttac 433921 aaaaataccc gagataatgt gtacaaaatc aaaaaagaag gatgttgaaa tgaaacttga 433981 ccagattgat ctgaatatca ttgaggagct gaagaaggac agccgtttgt cgatgaggga 434041 attaggcaga aaaattaagc tgtcgcctcc atctgtaaca gaacgggtaa gacagcttga 434101 atcgtttggc atcatcaagc aatacacgct ggaggtcgac cagaaaaaac tggggcttcc 434161 cgtttcctgc attgtggaag caaccgttaa aaacgcggat tatgagcggt tcaaaagcta 434221 tattcaaaca ttgccgaata ttgaattttg ctaccggatt gcgggtgcag cctgctatat 434281 gctgaaaatc aatgccgaaa gcctcgaagc ggtagaagat ttcattaaca aaacatcgcc 434341 ctacgcgcaa accgtcactc acgtcatttt ctcagaaatt gacacgaaaa acgggcgcgg 434401 ttagagagtg ccgcgcgaag tctgttataa taacaggatg agcgtgaaag aaagagaagt 434461 gatcaagcat gtcaaaaaca gttgtattag ctgaaaaacc ttcagtcggc cgggatttag 434521 cccgggtact gaagtgccat aaaaaaggaa acggttatct cgaaggcgat caatatattg 434581 tgacttgggc tttaggccat ttggtgacgc ttgctgatcc ggaaggctac ggaaaagaat 434641 ttcaatcatg gcgcctagag gatctgccga ttatcccaga acccttgaag cttgtggtga 434701 taaaaaaaac cggaaagcag ttcaatgcag tcaaatccca gcttacccgt aaagacgtca 434761 atcagattgt catcgcgact gacgcaggcc gggaaggtga gcttgttgcg cgctggatca 434821 ttgagaaagc gaatgtccga aaaccaatca agcggctgtg gatttcatct gtgacggata 434881 aagcgatcaa ggaaggtttt caaaagctgc gcagcggcaa agaatatgaa aacctgtacc 434941 attctgccgt cgccagagcg gaagcggatt ggattgtggg gatcaacgcc acccgtgcac 435001 ttaccacaaa attcaatgcc cagctctcat gcgggcgtgt gcagactccg acgcttgcca 435061 tgattgcaaa gcgcgaggca gacattcagg cgtttacgcc cgttccgtat tacggcatac 435121 gtgctgcagt cgacggcatg acgctgacgt ggcaggataa gaaatcaaag cagacgagaa 435181 cgttcaatca agatgtaaca agccgtttgc taaaaaatct ccaaggaaag caagcggtcg 435241 tagctgagct gaaaaaaaca gcgaaaaaaa gctttgcgcc tgcgctttat gatttaacgg 435301 agctccagcg tgacgcccac aagcgcttcg gtttttctgc caaagaaacg ctttctgtcc 435361 tgcagaagct atatgagcag cataagctcg tcacatatcc gcggacggac tctagatttt 435421 tatccagtga catcgtcccg acgttaaaag accgtctgga aggcatggaa gtaaaaccgt 435481 atgcccaata tgtcagccaa attaaaaaac gcggcattaa atctcataaa ggatatgtca 435541 atgacgcgaa ggtgtcagac caccacgcga ttatcccgac cgaagagccg ctcgttctca 435601 gcagtctgag tgataaagaa cgaaagctgt atgacctgat tgcgaaacgt ttcctggctg 435661 tattaatgcc tgcattcgaa tatgaggaaa caaaggtcat cgcagaaatc ggcggagaaa 435721 cctttacggc gaaaggcaaa accgtgcagt cgcaagggtg gaaagccgtt tatgatatgg 435781 cggaagagga tgatgagcag gaggatgaca gagatcagac acttcctgcg cttcaaaaag 435841 gcgacacact tgccgtccgc acgttaacgg aaacaagcgg ccaaacgaag ccgcctgccc 435901 gctttaatga agggaccttg ctgtcagcga tggaaaaccc aagcgcgttt atgcagggag 435961 aagaaaaagg cctcgtcaaa acgcttggag aaacaggcgg cctcggcacg gtggcaacgc 436021 gtgccgacat tattgaaaaa ctgttcaaca gctttttaat cgagaaaaaa ggccaagata 436081 tttttatcac atctaaagga aaacagctcc tgcagcttgt tccggaggat ctgaaatcac 436141 cggccttaac agcagaatgg gagcaaaagc tgtctgcgat cgcggccggc aaattgaaat 436201 cggctgtttt tattaaagat atgaaggctt acgctcacca aacggtaaaa gaaatcaaaa 436261 acagcagcca aaccttccga catgacaaca ttacgggaac ggcatgtccg gaatgcggca 436321 aaatgatgct gaaagtaaac ggcaaacgcg ggacgatgct cgtgtgccaa gatcgtgaat 436381 gcggaagcag aaaaacgatt gcccgaaaaa caaacgcacg ctgcccaaat tgccataaaa 436441 gaatggagct tcgcggccaa ggcgagggcc aaacctttgc gtgtgtgtgc ggtcaccgtg 436501 aaaagctctc tgtatttgaa aaacgaaaaa acaaagacaa agcgcgtgct accaaacggg 436561 acgtatcctc ttatatgaaa aaacaaaata aagatgagcc gattaacaac gcgctggcag 436621 aacagctgaa aaaactcggt ttggataaat aataaaaaaa cctgtgccta tcgcacaggt 436681 tttttattgg acttaggtcc tgttttctta atgttcaaaa agggaaaaaa aagctagcaa 436741 tctgcatttt ttttctttta tagtaaatgt actttgtaac atggcagtca tattttcgtc 436801 tataactatt tgtgagcgtc tgatttgctt caggcgacaa agggggattt gcctgtgagg 436861 catgtactaa ttgctgtcat cttattcttc ttatctatcg gactttccgc agggtgtgct 436921 gaagctggaa acaagaccca aaatcagtcg gcgacagaag tgaatgccag cccgctccag 436981 ccggcggaat atttcatcta tcacaattta atgaatgaca aagggctgat caaaaccgat 437041 ttttcagacc agccttctta cttgtcggaa tctctcggac tgtggatgga gtttctgctc 437101 agcaaaaatg acgcaccaca tttccaggat caatatcagc atctgactga ttcatttctg 437161 atgagcaatc acttggtgac gtggaagatt caaaatggcc aagcgagcgg gacgaatgcg 437221 ctgatagatg atatgagaat tatgctgtct cttgaccaag ccgccgcaaa atggggccgc 437281 agcgactacg cgcaaacggc tagggatatc ggcacgtctt tgaagacata caatatgaac 437341 aacgggtttt ttacagactt ttacgactca caggccgctt caaaggatgt gacgctttca 437401 tacgtcatgc ctgatgcctt agctgtctta aagaagaatg gaatcataga cgaagaaaca 437461 gaacagcgga atgccaatgt tctctattca gctcctttaa aaaatggctt tctgccgaag 437521 acatacagct cggagacgaa ggaatacaca tatgatagtg aaatcaacct gattgatcag 437581 ctttacgctg cttggcattt gccggaaggg gatgaaaaag catctgtttt agcggactgg 437641 atcaagcagg aatttcagaa aaacggaaag ctgtacgggc ggtattcggc atatacgaag 437701 gagcctgccg tccaatatga gtctccatcc gtatatgcct tagccgtatt gtttttgaca 437761 aaacagcatg aaaacagttc tgtcatcaaa gccatatatg atagaatgaa tgactttgaa 437821 attcatgatc cggtgaaatc gtattatgga ggctatatga gcggcactca gacgcattca 437881 tttgacaatc tgctgccgct gttagccgaa aggaagcttt ttaatgaaaa tatcattcag 437941 tgaatcacaa aaattatttg cttatttttc agggctcatc gcggccctgt ctttgtttat 438001 ttattatgtg tcagcccagc aatcagaagg tgctctgatc ctttgcatca catttggcgt 438061 catcgccgca ggcatctggt tcggcccgat ttacgcgctg gcagtgacct taatcgtact 438121 ctttgttctc ggcaccttaa tgatgttttt ccagactgga cagacatcgc tctttccggc 438181 tgaggaaggg ctgcgaatgc ttgtcgtgtg gggaatcgcg cttttgctgt tttcttttat 438241 ttctggaaga atccacgata ttacagcaga gcttcggcgc tcaatgacac ggcttcaatc 438301 cgaaattaaa agctatgttg ctgttgacag agtgactggt tttgataaca agcaaaggat 438361 gaagctggaa ctttcagaag aaatcaagcg ggcggagcgc tacggcaatt cttttgtgtt 438421 tttgctgctc catatgcatt atttcaaaga gtttaagtct ttgtacggtg aaaaagaaac 438481 ggaccgcctc ttccaatatg tcggtcagca aatcaggaca agcgttcggg aaacggataa 438541 gaaattccgt ccctctgacg agcgtatcgg gatcgtgctg acgcacacgc ctgctgaaca 438601 tatgccggcc gttctgacta agctgaagaa acaattggat acatatcagc tggaaaatgg 438661 aaagtatgtg tcgcttacgt tccacgtttg ctatttgccc taccgcaacg atatccaaac 438721 agctgatcaa tttttagaag aactggaaaa cgagatgatg atgaatgaac tataaaggaa 438781 tcacattgct atgcgtcatg atgcttctat tttcagctat tgcgtctttt cccgtttctg 438841 cgcaagcgaa agatcaggat gccggcattc tcatcatcta ctcaaccttg gacggcaaag 438901 agtcgtcaca agtcaaaatg ctcgatttgc ttgcgggcca ctttacatcc catgtgacag 438961 tcaaaaaaga ttcagacgtt gaagcgtcgg atttcaaagg gaaagaccat gtgatttatt 439021 acggccaaac gaaaagaaag ctcagccaaa aattgctgtc tcttatcagc ggcgtgaaaa 439081 aaccggttgt cgccattggc tataacgcag gccaaatcag ccaattttct gggctttcat 439141 tagcccgcaa agaaaatgtg tttcaggttc acagcaggtc agaaaaggcc gatgtgtctc 439201 tggaaagcgg gcttaacgtg ctgagtgtat caggcctgaa aggaacggcg ctttacacct 439261 tcaaagcgga tgaaggcaca acgcattctt ttatatggaa aacaaaaaaa gggaatgtgt 439321 acattggatt aacaaatttg ttaaatgaca atttgatcgt ggcgaaacag ctcagagaag 439381 ctttcggaga gaaggcgggg acgacgttat tgtatttgcg tctcgaggat atcagcccga 439441 tgtctgatga aaaactgctg cttcaagccg gtacatacct gcataagcgg catattcctt 439501 ttatcctggc ggtcattccg gtttacttga atccggaaac aggcgacaaa gtgtatttgt 439561 ctaatcaacc gaagatggtc aaggtgctga agaagctgca aagcatgggc ggcagtatca 439621 tagttcacgg ctatactcac gcttatcgct acagtgaaac aggagaggga tttgaatttt 439681 gggatgcaaa ggcggatcag ccgattacat ccggaaatgc cgaagacccc ccgtccattt 439741 tggagaaaga acaggacttc ccgaacgaac aagcctatca cagctatctt gaaccatttc 439801 gggaaaagga agaaacgtat acaaaacaaa aactgacgcg tgccattgag gatttgacat 439861 catcgggtct ttacccgctg gcgtttgaag cgccgcatta cacgatgtcc gaatatggct 439921 atcaaatcgc ctcgcagtat tttacaagca ttttcggcca ggtccagctc agcagcacaa 439981 catggaaaac atccggtgca cctccgtttg tgactgctcc ttcgatgctg cacggaatga 440041 cgctttatcc ggaaacgatc ggctttgtcg acacatcgaa gcaaaacccg ctcggtgaga 440101 tggaggagca tatctcccag atgattgatt ttgaaggcgg agtagccgga ggattttatc 440161 acccgtacct tgggatgaaa tatctgcctg agctggttga tcagatggaa cgcattccag 440221 acagtgaatg gcttgattta aagaaaacga aacaaaccgt caaaacagac aaagtggaaa 440281 ttcatacaag cggtgacgga acgattcagg tgaaaaacgg cgtaagcccc atttacgagt 440341 ttttcgatca tcaccggcaa acccctctgg aaaaggcgtt atggattctc tccgctgttg 440401 tgctcttatt tgtcatcatg tttgtcagtt atacgtttta cttgagagcc acattgaaaa 440461 aacgaatttt taaggagaga agaagccttg ggtaatacgc tgttctttat ctcgctaagt 440521 ttaatatggg ttatgcttct ctaccacatg ttcctcatgc agggcgggtt tcgccactat 440581 atgaccttcg aacggaatat cccgaagtgg agagaaaata tgaaggaact gccgaaggtc 440641 agcgtcctca tcccggcgca taacgaagag gttgtgattc ggcagacgct gaaggccatg 440701 gtcaaccttt attatccgaa ggaccggctg gagattatcg tcgttaatga taattcatca 440761 gaccggacgg gtgatatcgt caatgaattt tccgagaaat acgatttcat caaaatggtg 440821 attacgaagc cgccaaatgc aggaaaagga aaatcctctg cacttaactc gggttttgcc 440881 gaatcgaacg gcgatgtgat ctgtgtgtat gacgccgaca acacgcctga gaaaatggcc 440941 gtgtattacc tcgtgctcgg cctgatgaat gacgaaaagg caggcgccgt ggtagggaaa 441001 ttccgcgtca tcaatgcggc aaagacgctg ctgacgaggt ttattaatat cgaaacgatc 441061 tgttttcagt ggatggccca gggaggcaga tggaagtggt tcaaaatcgc cacgatccca 441121 ggcaccaact tcgcgatccg cagaagcatt atcgaaaagc tcggaggctg ggatgacaaa 441181 gcgctcgctg aggatactga gctgaccatc cgggtatata atctcggcta tcacatccgc 441241 tttttccctg ccgccatcac gtgggagcag gaaccggaaa catggaaggt atggtggcgc 441301 cagcgcaccc gatgggcgcg cggcaatcaa tatgtcgtgc tcaaattttt ggcgcagttt 441361 tttaagctga aacgaaaacg gattatcttt gatttgtttt attttttctt tacgtacttc 441421 ctgtttttct ttggcgtgat catgtcaaat gcgatttttg tagtgaattt gttttatgat 441481 ttgcatttgt ctgttggatt tttggcaatg attctctgga ttttggcgtt tttcttattt 441541 atgacagagg tcatgattac gttgagcatt gaaaaaacag aaatgaacaa gcaaaacttt 441601 tttatcgtat ttctcatgta cttcacatac tcgcaggcat ggattgtgct tgttatctac 441661 tctttattcg tagaaatcaa gcaccgttta ttcaagcaag aggtcaaatg gtacaagaca 441721 gaacgataca atcaacataa aagcgggtga cctttttgaa acaaataatg atttttctca 441781 caagcttcat gctgctggcg atgactggac aaacggctct tgccaaagac gtacaggtca 441841 gcggttcgct ccttgggaaa agcagccaag aacaagccaa acagcaggtg ctgacaagcg 441901 agctgattac actgtatgga tcaaaagaca gcgcagagct gacgtatcag atcccggcag 441961 gcgcctcttc gggcaatcag caattggtaa tcgaatacga ggcatcaaat cttttaattt 442021 ctccatcatc gttaacggtt gtcattgatg atgaaccggt caagacgtta aagcttgatg 442081 gtgattccaa acggaaaaca gtgaagctga atctgaataa aagccagtct gcgcaaggct 442141 atcacaacgt atcgctgaaa ttctacggcg taatgaaaga gggcgtgtgc gtcagacagg 442201 atacatcagg caactggatc aaaatttatc cggacagccg gctgacactt gctgacagca 442261 gtgaagcgaa gggaacgtcg ctggaccatt atccgtatcc tttcgcccaa tctggaaata 442321 cagcggaaga aacagctatc gtcattccgg ataacccaag ttcagcagaa atagaagctg 442381 ctgttaaaac agaaggctat ttgaaaacgg tggacagcag tgtcagtatt gcgtatgtca 442441 cggaatctga actgaaaaaa atcgataagc cgacgattgt tatcggcgtg gacaagcatt 442501 ggaacggcaa agtgaaaaaa ctgttgaaac aagccgggct acaggcaaaa ggagaaaacc 442561 ttctgcttgc ggagcgggtg ctgaaagcag agggcaaaca gcagccggtt ctgtttgcgc 442621 aagcggcgtc cgaggacgcg ctcacaaaaa aaatcagcgt gatgacagat cagacatata 442681 caggccagct cagcggcgat acactttcaa tcagcaagct tcagcagact gaaaaaaaag 442741 aaagcgataa gctgaccctt gagaattttg gagcgggtga tatcacaatt ggagccgaca 442801 aaacatcttc agcacattat ttttatccgg cttcggctgt tttagatgaa aaccaatcgg 442861 cgaagctgtc gcttaaactg aaaaagtctg aaacgattca agcctcaacg gctgaaaacg 442921 agtcagcctc tcaggctgca gaactgaaag tgatgatcaa cggccagccg cactcggtcc 442981 ggcttgatga attaggaaaa gaagataaaa acggattcta tcatgtcaca gtgaaagtgg 443041 accctaagct gctgcaaaaa aaccgctaca ttgatattca gttcgtcacg accggtttaa 443101 aggaaaacaa cccttgtaac accactgatg aagaaaagtg ggtttttatc gataaaaaca 443161 gtacattatc atacgccatc aaaggcatgt ccccgtcagc ggattttcaa gagtggccgc 443221 tgccttacgc cggaaaccag gatcaaacaa cgttaatcgt gcttcctgac accgtaagcc 443281 aatcgaagct agaggagctt tctctcgtaa cagaatcctt tggcaacgaa gcacagcatt 443341 catatacggt aaagaaatca tctgacgtta cagcaaatga tgcgaaagga cgaaacctca 443401 ttttcatagg agggatcaat caattttctc ttctgaagga gaaatcatca gatctgcttg 443461 tgccgcagga aaagaacggc tcgtttgatg tatctagttt cgagatgctg aatgagacga 443521 caaaacaagt ggtatttacc caagcatcgg tttgggattc acgctataca atggctgtct 443581 ttgcaccgtc aaaaggagat ggcacggctg tcacaaaaga gatcatcagt tatctgaaca 443641 gcaacgatga gtcggcaacc gtccttaatg aaacaaacag ccagcaggtg tttacaaacc 443701 accagcagct caaatcggaa acaaacagtt ccgatgcaga acaaccaaca caggatcata 443761 gccagaaatg gatgtatatt ggtgtgctgg cactcattat ggtggttgcg gcagtgttca 443821 tttggattgc cgtaagacgc aaaaaaagaa agacagatac agaataaaac agaggcgatt 443881 ttagcctctg tttttttatt tttggtaagt aaattccatt tgtggaacct gtcattttat 443941 ttttttctct cagccaataa gcctctttac aacgtgcggg aacgggagta tgatctcttt 444001 tagaaaacaa atcgcttaat ctgaaatcag agcgggggac ccaatagaac ggctttttgc 444061 cgttggggtg aatccttttt aggtagggct aactctcata tgcccgaatc cgtcagctaa 444121 cctcgtaagc gttcgtgaga ggagatgaat gaaacctgtg ttcgatgtta tggcacaggg 444181 gcatccgttt gcctctgtgt tttttgttgt tcatttttga atgcaaatcg catacagaga 444241 catcatagca gaaaggacta tcatcaacat gtgagagcaa gacactgatg gatgttttat 444301 tgttttaatt gaaaaatgag aaattaaaag gggaagacat cgatgtatca ttcaatcaaa 444361 cgttttttga ttgggaaacc actaaaatcc caagcagctg gagagcaaaa actgacgaaa 444421 ttaaaagcct tggctatgct ttcctcagat gcgctgtcat ctgtcgcata tgggacagaa 444481 caaattctaa tcattttggc aacaatcagt gcagccgcat tttggtactc cattccgatt 444541 gcggttggcg ttctcatctt gctgctcgca ctgattcttt catacaggca aattatttac 444601 gcttatccgc agggcggcgg ggcgtatatc gtttctaaag aaaatctcgg tgaaaaaccg 444661 ggattgattg cgggcggttc attgcttgtt gattatattt taacagtagc ggtaagtatt 444721 tccgcaggca cggatgccat cacgtcagcc tttcctgcat tgcatgatta tcatgtgccg 444781 atcgctattt ttctcgtgtt agtgattatg attttgaacc tgcgcgggct ttcggaatca 444841 gcatccatac ttgcctaccc ggtttatctg tttgtggtgg cgcttttggt tctcattgca 444901 gtcgggttgt ttaaacttat gacaggacaa atagaccagc cagcccatca tacatcgctc 444961 ggcacacctg tagccggcat tacgctattt ttgctgctta aggctttttc ctccggatgc 445021 tcagcgttga ccggggttga ggccatttct aatgcgattc ctgcattcaa aaacccgcct 445081 gcgcgaaacg cggcaagaac gcttgcgatg atggggattt tgctggcgat tctgttttcc 445141 ggcatcacgg ttctcgcgta cgggtatggt acggcgccga aacctgatga aacagtggtt 445201 tcacaaattg cgtccgaaac ctttgggcgg aatgtgttct actatgtcat ccaaggtgtc 445261 acatcgctta ttttggttct tgcggcaaat acgggattct cagccttccc gcagcttgcc 445321 ttcaacctgg cgagagacca gtatatgccg cgaatgttta cagtcagggg cgaccgctta 445381 ggcttctcaa atgggattat ctttttaggc tttgcctcca ttgttctcat tatcttattc 445441 gggggacaga cggagcactt aatcccgtta tatgctgtgg gcgtatttat tccatttacg 445501 ctttcacaaa ccggcatgtg catgaaatgg atcaagcaaa aaccaaaagg ctggatcgga 445561 aaaatgctga tcaactcctg cggcgctctg atatcattta tggttctatc cattctgttt 445621 gtgacgaagt ttaatgtcgt atggcctgtg ttaatcttta tgcctatcgt cgttttgctg 445681 ttttttgcga ttaaaaatca ctatactgcg gttggtgaac agcttcgcat cgtagacaaa 445741 gagccggaag aaatcaaagg caccgttgtg attgtgcctg tggccggtgt caccaccgtc 445801 gtgcaaaaat cgattcacta tgcgaaatca ctgtccgatc aggtgatcgc cgttcacgtg 445861 tcatttgaca gagaacagga aaagaaattc gaaaaacgtt gggaagagct taataacgga 445921 gtgcgtctcg tgacgcttca ctcctcttac agaagccttg tccatccgtt tgataagttt 445981 ttggaaacag ttgaggcaaa agcgaagaag gagcagtttt ccgttatggt gctgtttccg 446041 caatttataa cgaaaaaacg ctggcacacc atccttcaca accaatcggc cttcctcctc 446101 agagtccggc tgttctggaa aaaggacata atggttgcca cactgccgta tcattttaaa 446161 aagtaaagct ctaggaccaa gggaatcacc ttggtccttt ttagcgggaa aaggaggtat 446221 gggggtgtat acacaaggtg cttttgtgat cgtattgaac gaaagtcagc aaattctgct 446281 ggtgaaacga aaagatgtcc ctctatggga tttgccgggc ggcagggttg atcccgggga 446341 atcggctgag gaagcggcag tgcgggagat attggaagaa acgggataca atgcagcgct 446401 ttctgcgaaa ataggtgttt accaaaggcc aaagtttcaa gatgaacagc atctgttttt 446461 cggaagcatt acaggcggac aagcaatggc tgacggcaca gagacagcgg gattaaagtg 446521 ggtttccccg gggcgtttgc cgctttttat ggtgccgaat cgaaaaaggc agatcaatga 446581 tttcaagaac ggcgctcaag atgtaaatgt caccgtcaag gatagcgggt tgctcgcggc 446641 gatcgacctg ttgaaaagaa gactgggcaa gtgattcagg tctccgggtt ttaaagcctt 446701 tctcctgtgg tattgaaaaa aggaaaaagg aggatacgtt atggcacaca aaactgcagg 446761 acaagcaatg acagagctgc ttgagcaatg gggagttgat catgtatacg gcatccccgg 446821 agacagtata aatgagttta tcgaagaatt aagacacgaa agaaatcaac tgaagttcat 446881 tcaaacccgc cacgaagagg tagcggcact ggcagccgcg gctgaagcaa aactcaccgg 446941 caagatcgga gtctgtctgt caatcgcagg gccgggagcg gtgcacttat taaatggttt 447001 atatgatgct aaagccgacg gcgcccctgt gctggcgatt gcaggacagg tttcttctgg 447061 cgaagtcgga cgggactatt tccaggagat taagctggag caaatgtttg aggacgtggc 447121 cgtgttcaac agagaggtac atagcgcgga atcacttccg gatctcttaa atcaggcgat 447181 caggaccgcc tacagcaaaa aaggcgttgc ggtattgagc gtgtcagatg atttgtttgc 447241 ggagaaaatc aaacgggagc ccgtgtatac ttcaccggtg tatattgaag ggaacctaga 447301 accgaaaaaa gaacagctcg tcacctgcgc ccaatatatt aataacgcta agaaaccgat 447361 tatcctggca gggcagggaa tgaaaaaggc gaaacgggag ctcttagaat ttgcggacaa 447421 agccgccgct ccgatcgttg ttacactccc ggcaaagggt gttgttcccg ataagcaccc 447481 acattttctc ggcaacctcg gtcagatcgg aacaaagccg gcttacgagg caatggagga 447541 atgtgattta ttaatcatgc tcggaacgtc attcccgtac cgtgattatt tgcctgatga 447601 cacgccggcg atacagctcg attcagaccc ggcaaaaatc ggaaaacggt atccggtgac 447661 agcgggcctt gtctgtgatt cggctctcgg tttgcgcgaa ttgacagagt atattgaacg 447721 caaggaagac agaagattcc tgaatgcctg cacagaacat atgcagcatt ggtggaacga 447781 aattgaaaaa gatgagacag aggcaacaac accgcttaaa cctcagcagg tcgtggcccg 447841 tcttcaggaa gcggcagccg atgatgcggt gctctctgta gatgtcggca ctgtgacagt 447901 ctggatggcg cgtcatttca aaatgaacgc gaatcaggat ttcatcgttt ccagctggct 447961 tgcgacaatg ggctgcggcc tgccgggagc gattgcagcg agcttgtccg aaccggaacg 448021 ccaggcgatc gccgtctgcg gtgacggggg attttccatg gtcatgcagg accttccgac 448081 cgccgttaaa tataagctcc cgatcacagt cgttatttta aacaacgaaa atctcggcat 448141 gattgagtac gagcagcagg tcaaaggcaa tatcgactat gtcacaaaac ttcaaaatgt 448201 cgactatgcc gcatttgcag aaagctgcgg agcaaagggc atcaaagtga ccaaagcgga 448261 agagcttgcg ccggcttttc atgaggcgct gcactctgac caaccggtcg tagtggatgt 448321 catgattgga aacgaaccgc cgcttcctgg caaaatcacc tacgggcagg cgaaaggctt 448381 tagcaagtac atgctgaaaa acttcttcga aaaccaaaaa tttgaaatgc cgtcactgaa 448441 gaaaagtttg aaacggttat tttaaaaaaa caggggccct aagagccctt gttttttttt 448501 ttttttttgg aaacaaatgt attttcagca tgtttgaatt cataaaatga tcggtatatg 448561 tattaggaac tgatttcgcc atactcgaaa cagacaaaag gacaaatgca tcttgtttca 448621 aaggaagatg catttgtcct tgcatgctta ttcttatcaa atcttacaga actcttctca 448681 taataggtta tttttctttt ttcttcagcc cgaagaagaa aggaaaagca gaaccgacca 448741 agaaggtgcc gaataaaaac atgccgccga taaacacgtg gaaatttgtg tgtccggccg 448801 taaacgccgt gattagggaa atgatactga gcacgatcat ggcaatgccg ggcgcgactc 448861 tcatttttcc cttggattta tgggcagcaa cagaacataa aatgccgata acaataggaa 448921 caatccacaa ataaaacaga ataaatactg acatcatcaa aactccgatt tttcttctat 448981 cataacaaat ttctgtcaaa aagggtatca atgagctttt gcggaaaaat aaaaaccggc 449041 tttagaagcc ggttttttta tcgaaacgta tctacaatta aaaacacatt caaagcaacg 449101 atcaatacag caatcagcca agacaccact gtgatccatt tggcgttgat cagagatccc 449161 atgatccgtt tattgcttgt aaacataata agcggaatga gggcaaaggc gatcccgaag 449221 gacagcacga cctggctcag tacgagagcg gtcgtcggat taacacctga cgcgatgatc 449281 aagatcggcg gaatgatcgt gataaaacgc cgtacataca gcggaatgcg gtagttgata 449341 aatccttgca taatcacgtc gcctgaaagt gtgccgacag acgaactgga tagaccggca 449401 acgagcagcc cgatcccgaa caaagccgca gacatagggc tgacaagatg tccgaattgc 449461 tgaaatgcga cgtcgagatc ctcaacaaac aggccgtttt tgaagaataa tgcggcagcc 449521 acaatcagca tacttgcatt aatagcccct gcaatcagca tcgctattaa aatatcaata 449581 aattcaaacc taaagatttt tttccgttct gcatcagttt tgccaaccac ccgccgctgt 449641 gtaagggcag agtgtaaata aatggcgtgc ggcataacag ttgcgccaag aatacccgct 449701 gcaagaagca cactgtcggt gccatgaaac gccgggacaa aaaggccctt catcactgac 449761 acggcatcag gctttgcgaa aaaggtctgc aacgcaaagg cgatcacgac cacaaacagc 449821 ataccggcaa tacctgcttc aagtgagcga taaccacggc gctgaagctc caatatcgcg 449881 aaagaaccga tcgccgcaat aatagacgct tcaagcatcg gaatgccgaa cagcaaatac 449941 agtcccagag ccgctccgat aaattccgcc agatcagttg cgataatgac caactcgccc 450001 tgaatccata atccgatcga gacaggcttc gggaattctt cacgggcaac ctcaggcaga 450061 tttttgcctg tcgcaatacc gagtttggcg gatagggatt gaattaaaag cgccatgata 450121 ttggaaaata agatcaccca taagagcata tatccgtatt tagaacccgc cgaaatattc 450181 gttgcgaagt tgccgggatc aatataggca atggctgcta taaatgcagg gccgagaaaa 450241 gggagcagcc ctctgaatcc tctgattttc ccgtcaagcg catcttggac ggctttggaa 450301 cggggagatt gtgctgtgat gtccttgttc atcatgtctc acctgaattc tgtttgtttt 450361 tgccgtacaa caaagagttt ccttaaggca aattatttta tctacatcat atgaccatcc 450421 cggtttcttg tcaaccgaaa atgttcaaaa tacacttctg aatttttccc tgttatgtaa 450481 catgatatgt agggattcgt gataaggtcc catataaaaa gacatcgttt catttcgaaa 450541 cgatgcctcc tgtatctaat gagtctaggc ttccttccgc agcccgcgga atataaggcc 450601 cagcaagaac acgaagatgg ctgccccgat gatggccggg aaaatagcaa agccggcgag 450661 gctcggtccc catgtgccaa gaagtccgtg cccaatccaa gcgccgatca gcccggcaat 450721 catagagccg aaaattcctc ccggcagccg gtttcctaca atggcgctcc caattaatcc 450781 gataacaatt gcaacaacta atgaaaccaa aaagctaagc atcatgatca cctctcataa 450841 atgatttacc aatcaataac cgctcctgat catttcgaaa cacttgaaag catattcctt 450901 tatgatcctg ttttaatctt tctctgcaca ctgccgtcag ctaaatgaac aatgacctca 450961 gtgcctttat gcgccgcgat ttcctttgcc cgttcaatcg cttctttctt tgtatccttg 451021 atttcagaca cacgtttggc gccctcggct ttgactgccc agcctttttt atgcttaata 451081 acatgctctg ctttattcat gagctcgggg ccgctgccgc tgcttggatc agcatcgcgt 451141 tctgtctcat catcatgcgt caggaaatca tcaatttcat ctgtagaggc gttttccgcc 451201 cattccttcg ctttgcttgt cgcaattgga atcgcgcgcc cttcctcata gccttcatca 451261 atcatcgcat tcgcaatgtc tatcgccttt tttctcaccg gcttctcaag attttttaat 451321 gaagcaggat aatccttcat cgaccaaggc atgtctatca ctccttttcc ttttataaaa 451381 atggtacccg caggtgaaaa ataaaaacgc atccgaaaaa atgaaggtat actatatagt 451441 agaaaaaacg gaagggaagt gcgggttggg tgccaacaga acgaaaagaa gacttacatc 451501 agcaattaaa agagatagag aaatgggaaa aagatcagca aaaagtctgg ttttgggaaa 451561 agctcagccg tctcccgttt caactcctgg acaagctgac accagaattc atccagaaaa 451621 agatcggcaa gctcttggat gaggtcggca gctttgttca aacaggcgga cagtacctga 451681 catctgaaaa acagattatc aggatgtttc aaaagaaact gccggaggag atctttgaat 451741 cgctggagga catccggaaa gcgcctcttc ctgtcatgga tgaaattgcg gaaggaatgg 451801 gcaaaaacag aaccaacgca gcaaccgttc aaggcgcgac aaccggtgtg ggcggcgtgt 451861 ttacgctggc ggcagacatt ccggcagtgc ttggcttatc actaaaaaca ttacaggata 451921 tcgcagtcgc atacggctat gacccaaagg agaaaaaaga acgagtcttc attgtgaaat 451981 gcctgcagct tacgtcggct gatgttgtcg gcaaaagatc gattttgcag gaattaaaac 452041 actacgatca agaccgtaca tataagaatg tcgcttctca aatccaaggc tggcgagaag 452101 tcgttttggg ctatcgagac acgtttggct ggaaaaaact tttccagata gtgccggttg 452161 ccggaatggt ttttggcgcc gctgccaatc gctcaacatt aaacgacatt accgagacag 452221 gcatgatgct gtacaaaaag aggcgcattc ttgaacgact gaaagaaaca gaacgagaga 452281 tggaatagca gaaagcagac ggacaccgcg atccgcctgc tttttttagt ggaaacatac 452341 ccaatgtgtt ttgtttgttt aaaagaattg tgagcgggaa tacaacaacc aacaccaatt 452401 aaaggaggaa ttcaaaatgg cagacaataa caaaatgagc agagaagaag caggtagaaa 452461 aggcggagaa acaacaagca agaaccatga caaagaattc tatcaagaga ttggtcaaaa 452521 aggcggagaa gccactagca aaaaccatga caaagaattc tatcaggaaa tcggcgaaaa 452581 aggcggagaa gccactagca agaaccatga caaagagttc tatcaagaaa tcggtgaaaa 452641 aggcggagaa gccactagcg aaaatcatga caaagaattc tatcaagaaa tcggccgaaa 452701 aggcggagag gcaacaagca aaaatcatga taaagaattc taccaagaaa ttggctcaaa 452761 aggcggaaac gcccgcaaca acgactaatc aaaagcataa aggcagacaa cctgtaaata 452821 aaaaagcgat ccggcacatc agctggatcg cttttttttg gaatcttctc aatttatgcc 452881 gctattgaga tacaataagt gaaaaagggg ttttcgctaa tgtccaagat gcaaaacttg 452941 ctcgccatcg caaatgaagt caaagaaaag cacgccaatt tttcaatctc agaggtcaac 453001 gaccactgcg tgcgccttgc ggtgtttacg ggagaatatg actggcacca tcaccctgac 453061 tcagacgaat tgtttattgt tcttgaaggg gagctgctga tcgattttaa ggacaaagaa 453121 accgcggtgc tcaaagcaaa tgacagcctg ctgatcccta aaggcacggt tcaccgcaca 453181 cgctcttacg tcagaacggt aaatctctgt gtggagcata aacaagccga aaccgtcatc 453241 atagaggagc agccatgcta atcaaaaaga tgatatgtga agtagatgct gcaaacgctg 453301 aagcatttgc aaaagcgcag tcacagtggg aagcgttatc gcatataagc ggctttatca 453361 aacaggccgg cggctggcga aaaacgatag acgagccgct caccgcagaa atcatcagtg 453421 tatgggaaaa cagagaagcc tatgatcatt ttatggagaa cgaacatgac agcatatacg 453481 aggaaaacga tcagaaggct gtaattcttt cgatagaggt gacggtgtac gaagaggata 453541 aaccgttcgt tcacgatctg ttacataacc ccgatatccg gtacgaacca aactggacgg 453601 ttctgaaggc ataatcaaag cccaaaacat catgttttgg gcttgtctct ttactcgcgt 453661 cccggaagtg tattatgaac aaaaggcggt gctggtttta actccggttt ttctccaaac 453721 gtttttgctt ctttcacata ttcaaaggct tctccgtccg gcgctttttc attcagccag 453781 ttttgctcgg cgcttacttc gccttcagag aaattgataa gctgatgtga gaactcttgt 453841 ttttcgagcg ctttcgggaa tgtacccggc acaaccggac cttcctgtgc ttctaattct 453901 ttaatggcgg cgagccattg gttctggtgc atcgtgtcac gcgccagcag gaagctgagc 453961 atatctttga cgcctttgtc atccgtcatt tcaaacaggc gtgcgacctg cagacggccc 454021 tgagattccg cattcaggtt ggcgcggaag tctgccagca ggtttccgct tgctacgata 454081 taaccgccgc tccaaggtac gcctgtactg ctttccggca tggcgccaag tcctgataca 454141 atcgcatggt gagggttcat gccgcctagg atggagccga tgaccggatc ttcagcagct 454201 ttttcctgct gatcaagagg ggcatcctca agaagtctgg caatcatcgt tgcgatcatt 454261 tcaacatgcc cgagctcctc agttgccgta tccatcagca agtccttgta tttttcattt 454321 cctcttgtgt tccagccttg aaataagtac tgcatggcaa ctgaaatttc tccgaattgc 454381 ccgcctaaaa tttcttgcat ttttttagcg aataatggat ctggacgatc tggtttagca 454441 ggatgctgca gcatttttgt gtgcttaaac atgtacccat ctcctttttc gtttatctct 454501 ttttatattt ccgatcgata gaaagataaa cgaaaaacag cgtatcgaga tgggaactat 454561 gaatcttttc gcagctccaa cagttcccgg atcagctccc ggccaaagat gggctcatac 454621 tgccggtaaa cagggtcaag acgcttcatc cattcttgtt tctctttatc tgacagctca 454681 taaatatgta tagcagaatt ctttttgatt tcttccagct gctccttgtt catttgttcg 454741 gcatacgttt cattccactc cgttgtctcc ttcatcgctt cagtcaaaat gcgtcttgtt 454801 tctggtgttt gcgccttcca gaagtgttca tcagtcatga cagcgtagcc gagataaccg 454861 tggctgctta ttgtcaaata gtcctgaaca ttataaaatt ttttagaata gatgtttgaa 454921 attgtatttt cttcgccatc gactacattg ttttctaaca gctgaaaggt agaattgaag 454981 gattcctgat gaggtgttgc gccaagcagc ttgaactgat cctcaatcac atcgctttgc 455041 ataatgcgca gatcctgccc ttttaagtca tccggtgttt tgaccggccc ttgatttgtt 455101 gtgatttgct taaagccgtt cgtccaatag gccaatcctt tcaattggtt tttctttaga 455161 gaatcaaaca gctgtgtgcc gatgcttccg ttcagccctt ttttgacggc gttgtaatct 455221 gtaaatgcat acggcagatc cagcactccc cattcaggcg agagcatgcc gagcttcgat 455281 gtggaggggg cgataaattg aacatcgccg ttttgcaatg cttcaatttc ttcaatgtcc 455341 gagtacaggc ttccattcgg aaatacttct atttttattt ttccgcctga tttttcgttc 455401 accagatcag cgaatttatt ggcggccagc ccttttggcg tattttcagc aaccacgtgg 455461 ctgaatttaa acacgatttg atcctgcagg ccttcctggt cgtcatcata aacaatcttt 455521 ttattgccgg tatgatcatg gaatccgata aataaagcgg ttgcaattcc agcgatcatc 455581 agtgcgagac atgcaagcaa actcttcatg aaaagccctc ccctatgtta aggataatgg 455641 gggctatgac attcgtaaag acctgaaagg agaagctgat gaacaaaaag aagctctcaa 455701 tccgttggaa aatcacgatc ttatcctata tactcgtcat tttctccttt ttgatcggcg 455761 gcattgtgct catcggcaac attcagcata cagaggagcg ggagctgaaa aagcggctga 455821 tgaatacggc ccggacggtg tcagagatga cagaagtgaa agaagccttg gcgcgaaaaa 455881 aacaaacaga agcggttcgc catgcggttg aagaaatcag gatgattaat gaagcagact 455941 atattgtcgt catggatatg aatcacatcc gatatacgca tcctgtcagc acaagcattg 456001 gcaagaaatc agaaggtgca gacgaggagg cagcttttgc ggagcacatt tatttctctg 456061 aagcaaaggg cgagatcggc acggcggttc gcgcttttta tccggtaaag gatcaagacc 456121 tgaaccaaat aggcgtggtg cttgtcggaa aaacgctgcc ggggatcgct gacatcctgc 456181 ttcatttaaa gcgtgatatc gccttcatcg ttgtgctgac actcggcttt ggccttgctg 456241 gttccttttt gctggcccgc catatcaaaa aacaaatgtt tcagcttgaa ccccatgaga 456301 ttgtccgaat gtatgaagaa cggacagcga cgtttcactc gatgaatgaa ggggtgatcg 456361 ctattgacaa tcgtctcgtc attacgatct tcaatgaaaa agcgaaacag atctttgaag 456421 tgcaggggga tctaatcggc aaggtgattt gggaggttct caaggattcg cgcctgcccg 456481 aaatcgtgga gcggaacaaa gcggtttata atgaagaaat tcgtgtcagc ggtaaggtga 456541 tcatgagcag cagaattccg atcgtcatga agaaaaaagt gatcggcgcc gttgcgattt 456601 ttcaggacag aacggaagcg gccaagatgg cagaggaatt gactggtgtc agaaactttg 456661 tggaggcgct ccgtgtccaa aaccatgagc atatgaataa gctgcacacg atcgccggtc 456721 tcatccagct ggggaaatct gaaaaagcct tgcagcttgc attccaggcg tcaactgagc 456781 aggaaaatgt gactgaattt ctgcaccgct cgattcaaaa tgacgctgcg gcaggccttc 456841 tattaagtaa aatcagaagg ggaagagagc tcggcattgc tgttcatata gatgaaaaca 456901 gcagtcttca gcaatttccc gagcatgttg atcagcatga tattgtcgtg cttttgggga 456961 atctgattga aaatgccttc ggctcatttg aaaccgttca atctgaagac aaacgaattg 457021 acattagtat cgaacaaaca gatgatatcc ttgctatttt aatagaagat aacggctgcg 457081 gaattgaacc gacacatatg cctcgccttt atgacaaagg ttttacggtc aataaaactg 457141 gcggcacagg ctatggcctg tatctagtga aacaaatcat agacaaagga tcgggcacga 457201 tagaagttga ttcacatgcg gggcagggga catctttttc tatcgttttt ccaatgaagg 457261 gggaggaagc acagcatggc tcgtaaagaa tggaaggttc tgctcattga agacgatccg 457321 atggttcaag aggtcaataa ggatttcatt acaactgtta aaggcgttac tgtctgtgca 457381 acggcaggaa acggagagga aggcatgaag ctgattaaag aagaacagcc agatctcgtc 457441 attctcgatg tgtacatgcc gaaaaaagac ggcatcaaga ccttgcagga gatcagaaag 457501 caaaagcttg aagtggatgt cattgtcgtc tccgctgcaa aagacaagga aacgatctca 457561 ctcatgctgc aaaacggggc ggttgactat atcttaaagc cgtttaagct tgagcgaatg 457621 agacaggcac tcgaaaagta caagcaatat aaacaaaaaa tcgaagcgaa tgatacgctg 457681 tcccaggaac agctcgatgc gatcctgaat attccgcagc aggccgtaca ggatctgccg 457741 aaagggttga atcacttcac gatgaatgaa gtcactgctt ttttgaaaca gcaaaccgca 457801 tccctttctg ctgaagaggt tgccaaggcg ctcggcatcg ccagagtgac agccagacga 457861 tatcttgatt acttagaaaa aaccgggatc atcaaattgg acgttcaata cggcggagtc 457921 ggccggccgg tcaaccgcta cgtgttaaaa ggataaacct gagaccaaaa agaccaaaat 457981 gtccgttatg atcataaact tccccagact gtatgaaaac gctatcattc tagtaagaaa 458041 gacacaaaag gcgaatagga cagggggatg aaggatatga aactgtttaa aaatttaaca 458101 gttcaggtca taaccgcggt catcatcggg gtcattgtcg ggctggtctg gccggatgtc 458161 ggcaaagaaa tgaaaccgct tggtgataca tttatcaacg ctgttaaaat ggtgatcgca 458221 ccaatcattt tcttcacaat cgttctcggg attgcaaaaa tgggcgatat gaagaaggtt 458281 ggaaaagtag ggggaaaagc gtttatctat ttcgaggttg tcaccaccct cgcactcatt 458341 atcggtttat ttgtcgtcaa tattatgaag ccgggtgcgg gtcttgatta cagcaagctt 458401 gaaaaaggag atgtatcaca atacacgcaa aatggcggtc agggaatcga ctggattgaa 458461 tttattacac acattgttcc gtccaacatg gttgatgcct tcgcaaaagg ggacattttg 458521 caggtcttat tcttttctat tcttttcgga gtgggtcttg cggcattagg cgaaaaagga 458581 aaaagcgtca ttgatttctt cgacaaggtt tctcacgttt ttttcaaaat tatcggctac 458641 attatgcgtg ccgcgccaat cggggcattc ggggcgatgg cgtatacaat cggacacttc 458701 gggctcgatt ccatcaaacc gctggcaagc ttaatgatgt ctgtttatat tacgatgttc 458761 ctgttcgtat ttgttgcttt aaatatcatc tgcaagcttt acggattcag cctgtggaat 458821 taccttcgct tcattaagga tgagcttttg atcgtgcttg gcacaagctc ttccgaatcg 458881 gtgcttccgc gtatgatgga taaaatggag cgctacggct gttccaaatc cgttgtcggg 458941 cttgttattc cgacgggcta ttcgtttaac ctcgacggca catccatcta tttatcaatg 459001 gcgactgtct ttttggcaca ggtgtttgga gtagacctca gcatcggcca gcaaattacg 459061 attatcctcg ttctgatgct gacatcgaag ggagcggcag gtgtgacggg aagcggattt 459121 atcgtccttg cctcaacgct gtcagcgctg caggtcattc cgctggaggg gcttgcactc 459181 ctgctcgggg tcgaccgttt catgagtgaa ggaagagcca ttgtgaacct gatcggaaac 459241 ggaatcgcca cgatcattgt tgccaaaagc gaaaatgaat ttgatgaagc aaaaagcata 459301 gaggctgttg aaggcatgaa aaaaatgaaa acagcagtct gaaaaaagaa cggcccatcc 459361 atgggccgtt tttttaattg tttaagaatt attaaggtaa ggacagagac ctcagcattt 459421 ttttgttata taatttacaa atggatacta tattgaatga aggacgtttg tcctaacagg 459481 agtgtataaa tggccgcttt agttaaattt tttcagcacc cgggagtaag gcgtttctcc 459541 atctttgtcg tgttaactgg tgtgttatat ctatttaaga gcatgatcaa cttaatattg 459601 cttaccttca ttttcacatt tctaatggat cgtttggagc ttgtcgtgcg gcagtttgta 459661 agccagttct tccgcgtgag ccagcgggtt gtcattacgt ttctttacat gttgctggct 459721 gtgctgctta cagtcggggg ctttgtgttt tatccggtcg tcgcggcgca gatccagcag 459781 ctggtaaagc agattaaaca tattgcgtat catcctgaca gcatcccttt ctttgatgag 459841 atcaccagtg tcttcggaga tattaacatc agttcatatg tcaaagaggg cttcaatgta 459901 gtgtatacgt atctggccga tatcagcaca ttcggcttgc aggtcgtgat ggcgctcatt 459961 cttagcatgt ttttcttatt tgagaaaaaa cggctttctg aattcatggc gaaatttaaa 460021 acgagcaaac ttagggtctt ttatgaggag attgcttttt tcggaagcaa atttgcaaga 460081 acgttcggca aggtgctcga ggctcaattt atcattgcgc tcgtcaactg tattctgacg 460141 tttatcgcgc tttggattat gcattttccg cagctgtttg ggctttcgat tatggtgttc 460201 ttccttggat tgatccctgt agcaggcgtc gtcatttccc tgattccgct cagcattatc 460261 gcctacagca ctggcggtgg aatgtatgtg ctctacattg tccttgtcat attcgccatt 460321 catgcgatcg aaacctattt cttaaatccg aagctgatgt cggcgaaaac agagctgcca 460381 atctttttca ccttcacagt actcattttc tctgaacact tcttcggcat ttggggttta 460441 attatcggga ttccgatctt tgtgtttctc cttgatattc tggatgtcac caacaaggaa 460501 gataggtcta aaggaccccg agagaatagc gataaaaagt agtttaaaat cgaataatga 460561 gtgtgcctcg atctgccggc ctgcctgttc agggcatgga attaagactc ggaatcggag 460621 cttggcattg ccttgcacag tggtgaacac aacaggtgac aatgcttgtc atcagtacgg 460681 aaactgaaaa gaacaaacag tcggagcaaa cgctcatcat cggtttaacc aaacatttgg 460741 aagcaacaaa tgctataata caaacagtgc ctaatgttgg gcactgttta ttttttgtcg 460801 aaaaaggagg aaggctttat ggctgagccg attttacata ttgaaggcct cgataaaaaa 460861 attgggtcta aacagatttt aaaacagatc agcatggacg tcatggaggg tgaaatcatc 460921 ggccttctcg gtccgaatgg ttccggaaaa acaacactca tccgtatcat cgtcgggctg 460981 ttgaaacaaa acagcggaag cgtgacaatc agcggattcc agcatgatac agagtttgaa 461041 aaagcgatgg aagcggttgg agcgattgtt gagaaccctg agttctatcc gtacctgaca 461101 ggctgggaaa acctcaagca ctttgcgaat atgcacaaaa aaatagcgga tgaacggctt 461161 gatgaagtgg tggaacgtgt cgggctgacg tcagcgattc atgataaggt gaaaacctat 461221 tcccttggga tgcgccagcg tctgggaatc gcccaggcaa ttcttcaccg gccgaagctt 461281 ctcattctag atgaaccgac aaacggcctc gatcctgcgg ggatgaagga ttttcgggat 461341 catattaagg aactcgcaga aatggaagga acagctgtcc tgttcgccac tcatttattg 461401 cgcgaggttg aagacttgtg cgaccgtgtc atcatcattc aaaaaggtga gatcaaagcg 461461 gaagtcagct tacaaggaac cgatcaaacc acagaaaaag cgattataga agtgcagccg 461521 caagaaaaag cgctcaattg gctgacaggc aatcaatatc aagctgagag ccaagacggg 461581 acgattgtag ttgaggtggc aaaagaaaac ataccggagc tgaaccgatc acttgtcgga 461641 caagatctga atgtattttc cattacgcct tacacgcagt cactggaaga cgaatttata 461701 aaagcgacaa cagctcatca agaggaggga gaagagcttg tctaaattaa tttggaatga 461761 acatatgaaa ctttttaatc ggaaggtcac tttggtttct cttatcctga tggctgtctt 461821 tcaattcttc atggcattga tcattaaacg gattgtcatc agtgccggaa cagatgaaaa 461881 cttcatcggc tatttatcgt atacaccgag cctgaacatt ttgctgcagg ctttaacgat 461941 cgtaattgca gcaacaattg tttcgatgga atttgataaa aagacgatca aatttttgct 462001 cattcgtccg gttaaacgcc aaaaggtctt ttggtcaaaa ttaatcacag tcgtgatggt 462061 cagcttctat ttgtatttgg catactacat tctggcatta ttattcggtc tcttgttttt 462121 tggcacatcg gtgactgcgg aatcaaagac attgctggtc aacaccttgg cgctgatcgg 462181 gtcaaactgg cttgaagctg taatgatggg attattcggg ctgctttgtt cttcgctgtt 462241 ccgcaatagc gcggtagcag ttgttgtttc ttttgtcgtt ttatacggag cgagtacact 462301 tgttcagctc atgaagttgt ttgaaaacaa gtggggcagc tttttgcttt ttgcgaacac 462361 tgactttacg caatacagaa gcggagagac agcgttgttt tcaggcatga cgccattgtt 462421 ttcaattgga attctcatca tacatgccat attcttcatc gttgttggct ggtggtgctt 462481 ctgtaaacgg gatgttcggg tctaaaggca aggaatgaca tttttgtgaa aaagctcacg 462541 taaatcaata tcatttgata ttttggttta tactaaaggt actgacggag gtgtctcgat 462601 tgaggaactt tattaccgct ttaccgatcg tattgctgct tggattctca tttgtgtcat 462661 tcatgtttca gtttgaacat cttgtttatt tcaggctcgc gcttgggttg ttttctctcg 462721 tgggactgta catgatatat aaaatgaaga cgggcatccg ctattttatc atctatctgt 462781 atgccagctg gattgtgttg gccgcagtga ccgcttttga agagccgatt ttctcaagct 462841 ttttctttgg cggcctggtg atgacgatgg gttacctgac atatatgctg atttatctcg 462901 gcatgaaaca agaccgggat gcaaatcctg tgtaatcgcg ctgttccctt ggggaacggc 462961 gtgtttttct atactgggca aaaggttaac agttgcggaa aaatggcagg aaatctataa 463021 tacatattaa atttatcgga attaaaactg gggggctgcc ggatgtcatt atttatacaa 463081 aacgatcaac agcggcaatg gatggagaaa atcggacgga ttgcggatga atttcagcaa 463141 acagctgctg aagatgacga acagggacgt tttcctgcag agaaaataca aaaactgcgt 463201 gatgctgggt atacagcatt aacattgccg gcatctcatg gcggaggggg catttctgtt 463261 tacgatatgc tcttgtttca agaacggctt gcacggggag atgctccgac ggctcttagc 463321 atcggctggc atttgagcgt gatcggggag cttggagaag gcaacagctg ggatgaagac 463381 gtatttgcat ttgttgccaa ggaagtccaa aacggagccg tcattaacag ggcggcgact 463441 gaagcgaaaa ccggaagccc gacaagagga gggcgtcccg gtacacacgc cgtcaaaaag 463501 gatggcaaat gggcagtgaa cgggagaaaa acctttacga cgatgtcaca agctctggat 463561 tattttttag taaccgcatg gattgaggac aaacaaacaa caggcgtgtt tctcattcat 463621 aaagatgatc ccggcttgtc gattgaagaa acgtgggata tgatggcgat gcgggcgact 463681 gggagccatg accttgtact gaacgaagta atgcttgatg agaataagct ggtggaactg 463741 cttcaagggc ctcgtggagc taagccgaat ggctggctgc ttcacattcc tgcgatttat 463801 cttggtgtgg ctcaagctgc tcgtgactat gcagtgcaat ttgcatctga gtattctcca 463861 aacagcttga atggaccgat caagaatgtc ccggccgtac agcaaagaac aggcgaaatg 463921 gagcttgaac tgctcaatgc cagacacttt cttttccata tcgctcaatt gtatgacgat 463981 ccggtgcggc gtccacactt gaccagcgag ctcggtgcgg cgaaacatat cgtcacaaac 464041 gctgcgctgt ctgttgttga taaagcgatg agaattgtcg gggccaaaag cctggaacga 464101 accaacccgc ttcagcgcta ttaccgtgat gtgcgcgccg gtcttcacaa cccgccgatg 464161 gatgacgccg tgatacacaa gctggcagct gaagcgtttg agtcataaaa aaaagagcct 464221 taccggctct ttttatgtat tgttttgctc ttgcagattt ttttgatgct tgcggtcgat 464281 cctgtcataa ataacgttca tcagctttgg attgcccata atcgcctctt tgttttcctg 464341 gatcagctgt tggtaagttt tcactttacg cttcggcatg ctccggcgcc ctcctgacat 464401 gtttgtattc actttctaac tccgtcagcg acaattcata cagatgacgc tttgactttt 464461 tgtatatacc attctgtatt aacagatgaa tgagctgttt ttttctgatt tctgcagact 464521 gaggtgtcat tgtgtcacca acctccaatc aaacgatatt gataatcatt atcaattaac 464581 ttcagtatac aatgtccgca atagcctgta aagatgaaaa gagtcctatt cttggccaat 464641 ttacaaacat tcaacaaatc gacaaaaagt ttcccgggca ataatttgct gtcgaaatat 464701 tccgcttcat tgaacgcacc ctgctatttt tcatgttttg aaccatacta tgtaatagaa 464761 tggaggctgg tattcaatgg agcggacaga aaatctgaaa aagggagaaa aaggggcgct 464821 cctcaatatt tttgcatatg tcatccttgc tgttgtaaag ctagttatcg ggattctata 464881 tcattctgaa gcgctgagag cagacgggtt aaataatgga acagatattg ttgcgtcagt 464941 agcagtgctg ataggattgc ggatttctca aagaccggct gacagcgatc atccatacgg 465001 ccattatcgg gctgaaacaa tttcgtctct tgttgcgtct tttattatga tggcagtcgg 465061 cattgaagtg ttaatcggcg gaggaaaagc gattgcgggc ggcacaacgg aaacgccaaa 465121 tcttatcgcg gcatggacgg cgttaggcag tgctgtgttt atgtatggca tctatttata 465181 taacaaaagg ctggcagcgt ccattaaaag ctctgccctg atggcagcgg caaaggacag 465241 caggtcagac gcttttgtaa gtgccggcgc gtttatcggt gttttttcgt cccagctgaa 465301 gctgccgtgg gttgatccgg taacggcttt tatcatcggc atcatcattt gcaaaactgc 465361 gtgggatatc tttaaagacg cttcacattc cttaacagac ggcttccatt taaaagatct 465421 tgagccttac aaacagaccg tcggcaggat cgaaaatgtg catcgcctaa aggatgtgaa 465481 agcgaggtat ttaggcagta cagttcatat cgagatggtg attacggttg atccgaagct 465541 tacagtagaa gaaggccatg gagtggcgga tgaagtagaa gacaaaataa aacatgaaca 465601 cgatgtcact catgttcatg ttcatgtaga gcctgacgac ataaaataag gctgtttaac 465661 gaattagctt atatgttcag ataaaaattc agtcacttct tcaggcgttt tggcattggc 465721 gctgtgaagg tgagctgttt tttcaccgtt cttgaaaata agcaggctgg gaatgcccat 465781 tacttggtat ttttcagcca ggtcaggaag ctcgtcctta ttcagctcat accagtcgtt 465841 ttggttgtat tcttccaaaa tatcgccgat gaacatattc atgcgtgtgc agtctgggca 465901 ccaatcagca taaaacttta caatgatttc tttatcagat tgaatcagtt cattaaattg 465961 ttcgtttgtt gtgatttttt tcatatgtca catctccttt tcaatgccat tttaatataa 466021 aataaaaagg aattacatac aaatgcattc aacatcagca tgcccaaaaa taattagatc 466081 attttccggt gaaaatgata agatagtaaa gatgaattgt agtgggggga gtatccattg 466141 aaaacaagtc taggattagt gtacggagga aagtcggcag aacataatgt ttccctgcag 466201 acagctctgg ctgtaatcaa agcgctaaat actgagaagt ttgatataca tccgatttat 466261 ataacagaaa aaggcgaatg ggttagaggc gcccgtttaa ctgaacctgt ttcaaacgtg 466321 aaaatgcttc aatttgagca aggaggcagt gctttttctc cagctgccct gaaccaggag 466381 atgtttccgc aggaagcgtc acagcaaaat gaagccatcg acgtcgtatt cccgctcctc 466441 cacggaccga acggagaaga cggtacgatc cagggaatgc tcgagctgtt gaacattcct 466501 tatgtcggca acggagtgct tgcttcctca gctggcatgg ataaagttgt catgaaacat 466561 ttatttgcgc aggttggcct tgctcaggct aaatacgcag ctttccttaa gaaagactgg 466621 actcgttctc cgaaagaaag ctgtgaggag gttgaacagg aattaggcta cccttgcttc 466681 gtaaaaccgg cgaacctcgg ctcaagtgtc ggaatcagca aatgccgaaa ccgtgaagaa 466741 ctgcaaaaag cgtttgagct tgctttccaa tatgaccgca aagtcgtcgt tgaagaagga 466801 attaacggcc gcgagatcga aatcggcgtt cttggaaatg atgatcctaa atgctctgtt 466861 gtgggagaaa tcgcaccgaa gacagatttc tacgattaca aagcgaaata tgaggatgga 466921 gatactgatc tgatgattcc ggcgattgtg actgatgagg aatacgcaac aatcagtgat 466981 atggcgatca aagcgtttaa agcgatcgac ggttcaggac tcgtcagagc ggactttttc 467041 ctgacagctg acggcgaagt tctgatcaat gaagtcaaca caatgcctgg ctttacacct 467101 ttcagcatgt tcccgttgct ctggaaagaa gccggagtgg aatatgctga cctgattgaa 467161 cagcttgtgg agcttgcaaa agaacgccac gctgaaaaac aattgattaa gcatacattc 467221 taatgaagaa ggacactgcc ggtaaaaggg cagtgttttt tcccgtatat acaaaagaaa 467281 gagagggacc ttacttgatt aagcgaacag taaaaaacat tgccgaaatg gttaaaggca 467341 cactagcaaa tccgcaatat gaacaaacag tcattcatgg agtggcaacc gatacaagaa 467401 aactggaaca acatcagctc tttattccgc tgaaagggga acgttttgac ggccactctt 467461 ttgtggagca ggcctttgaa gctggtgtag cggctgttct ttgggatcgg tcagtaccaa 467521 atccgcccga gaatcacgcc gtcattttag tggacgatac ccttactgca cttcagcagc 467581 ttgcaaaagc ttatttgcag gagcttggca cgcgtgtcat cggagtaacc ggaagcaatg 467641 gcaaaacgac aacaaaagat atgattcacg ccgtattggg gacccagtac cgtgtccaca 467701 aaactggagg aaacttcaat aatcatatcg gtttgccgct gacggtttta gcgatgcctg 467761 aaaatacgga gatcgccgta ttggagatgg gaatgagcgc caaaggagaa attgacctct 467821 tgagccgact ggcaaacccg gatgcggcag tgattacgaa tatcggcgaa tcgcatatgc 467881 aagacctcgg ctctagagag ggcatcgcgg aggcgaagct tgaaatcata aacgggctta 467941 aagaagacgg agtgctgatt tatatcgggg acgaaccgct tcttcaaaat gcatacagct 468001 gccagacgaa aacgtacggt acgggaacgc ataatgatta tcagcttcag gatgtcagcc 468061 agagtgagga aggaacccat tttacaatca aagggataga aaacacgttt tttattccaa 468121 tactcggcaa gcacaatgtg atgaacgcca tggctgcaat tgctgcaggg gcttattttg 468181 gcatcgcgcc tgaggatgcg gcaaaaggac tgagcggcct aaaggtaacc gggatgaggc 468241 ttgaactcat caaaacagac agcggccttt cgataatcaa tgacgcttat aatgcgagcc 468301 cgacttccat gaaagctgca attcaattga cagaaagcct tgaaggctac ggcaaaaaaa 468361 tgctcgtgct cggtgatatg cttgaactcg gcgatcttga agaaacgttc cataaagagt 468421 gcggcgctgt gatcagccct gataaaattg accgcgtctt tacgtacgga aaactgggag 468481 cttttatcgc ggaaggcgcc ctgaaacact ttgagaaaga ccgcgtcagc cattacactg 468541 agaaaaaaga tctccttcaa gctgtgaagg aaaacgcatc aaaaggcgat ttgattttat 468601 tcaaagcgtc cagaggtatg aagcttgaag aaatcgttaa agatttaata gagagcccgc 468661 tttcataaga aaatattttg cgaaaaaacg catattgcat cataaaataa cctgatatgc 468721 aaacactaat gtatgccggc cgaaaattat gtatatctgg ccggctgcgg ctatgataca 468781 atatatatag gttatttcgc gatacgaaca tattcgtccg gacttttcat cgtgacccga 468841 agttctccgc tggattcttg ggagcggatg gagcagcagc cggcatattc gagatgccga 468901 tctgcttctc atcttattga aaaacaaata gtgtaatggt aagataaaac ttaaagtaat 468961 tcgggctttg tatacggatg gatcctgtcc ttcttgtcta aagggcagtt ttataagtgg 469021 taaatcacga cattactgaa acagcaatta gaaggagttt gaataatttg actataacgt 469081 ttcaagattt taatttaagt tctgatctca tgaaagcaat taatcgtatg ggatttgaag 469141 aagcaacacc gattcaggca caaacgatac cgctcggact ttcaaataaa gacgtcattg 469201 gacaagcgca aacaggtaca ggtaaaacag ctgcgtttgg tatacccctt gttgaaaaaa 469261 ttaaccccga gtctcctaat attcaagcaa tcgtaatcgc gccaacccgt gaattagcca 469321 ttcaagtatc tgaagaattg tataaaatcg gacaagataa acgtgcgaag gttcttccta 469381 tttacggcgg acaggatatt ggacggcaaa tccgggcgtt aaagaagaat ccgaatatta 469441 ttgtcggaac acctggacgt cttcttgacc acatcaaccg ccgcaccatt cgtttaaaca 469501 atgtaaatac cgttgtaatg gatgaagcgg atgaaatgct gaacatggga ttcattgacg 469561 atattgaatc tatcctttca aacgtgccaa gcgagcatca gacacttctg ttctctgcca 469621 caatgcctgc gccgatcaaa cgcattgcag agcgcttcat gactgagccg gaacacgtaa 469681 aagtaaaagc gaaagaaatg acggtttcta acattcagca gttctatttg gaagtgcaag 469741 aacgtaaaaa attcgataca ctgactcgcc ttcttgatat tcagtctcct gagcttgcga 469801 tcgtattcgg acgtacaaaa cgccgtgtcg atgagctggc tgaagctctg aaccttcgcg 469861 gatatgcagc tgaaggtatt cacggtgact taacgcaggc gaaacgtatg gttgcgcttc 469921 gtaaatttaa agaaggcgca atcgaagttc tagtcgcaac tgatgttgcc gctcgcggac 469981 ttgatatctc aggtgttaca cacgtataca acttcgacgt gcctcaagat cctgaaagct 470041 acgttcaccg tatcggaaga acgggccgtg caggaaaaac aggtatggcg atgacgttca 470101 ttacaccgcg tgagaaaagc atgcttcgcg caattgaaca aacaacaaaa cgcaaaatgg 470161 accgcatgaa ggagcctaca cttgatgaag cgttagaagg tcagcaacag gttactgttg 470221 aacgtcttcg cacaacaatc agtgaaaaca acctgaactt ctacatgaca gcggcagctg 470281 agctgcttga agatcatgat gcagtaacag tggttgcggc ggctatcaaa atggctacaa 470341 aagagccaga cgacacaccg gttcgcttaa cagacgaagc gccgatggtc agcaaacgct 470401 acaagaacca gcgctcttct aaacgcagag acggtcaagg cggcggctac cgcggcggaa 470461 aagggaaaag caacaaccgt tcttcctatg acaaaaagcg ttcaaacgat cgccgttctt 470521 caggtgacag acgccagaaa aaatcttact aatttgatcg attcagagcc caaaacatga 470581 tgttttgggc ttttttatgt tcgtgatttg ttattcagca aactttcagc tgacggaagc 470641 catttttctc tgtatgctta agaatgaaac ctttctgtaa aagagacgta taaataacga 470701 cgaaaaaaag ggaggtaggt atttttgaga gagcagccaa aaaaccaaat cagtccagac 470761 ggattaaagg tttggcgact tcaagagatc atcatatccg ctgtttgctt gcttattgtc 470821 attgcagttg cagtgttaag ctattatttt cattggccgt actggatcag cggcgtgctc 470881 ggcgctgttt ggctgctggg atcgattgtg acggtcttta tcattccgaa ggtccgtcat 470941 aaggtgtggc gatatgaagt ccatgaacat gaaatagata ttcagtcagg tatttttgtg 471001 gtgacacgtg tgattgttcc gatggtcaga gttcagcacg tcgatacgtc acaagggcca 471061 ttattaaaaa aatacaacct ggcaacggtg aaaatttcca cagccgcgac cgttcattcg 471121 atccccgctt tagagatgga ggaagcggat cggctaagag actccatttc ccgtctggcg 471181 agggtgactg acgatgatgt ctgaaccgaa acgcctgcac ccggtggcag tcattttgaa 471241 tttatgccat accattattc aaacgataaa aaatatcatt ctgccattct tttttgtgta 471301 tattgtcaat tcaaaccata ctgtccgttt ttacggagcc attgcgctcg gtgtgctgtt 471361 catctggctt gtagcggcaa gcattatcaa atggagaagg tttacctatc gaattgaaga 471421 tgatgaattt agaattgaag aaggcttatt tgttacgaaa aaacgataca tatcgattga 471481 tcggattcaa acaatgaata cgagcgcggg ccttgtccag caaatcttta agcttgtgaa 471541 gctgcaaatt gaaacagcag gcggaggcaa ggaggcagaa gccgttcttt ctgctatttc 471601 tgttgaagaa gcggaacgca tcaaagaagc tgtctttaag aaaaaagcgc aaagacgaga 471661 aaatgaactt gatgaagaac ggcttgaagc tgaagaggag ttggatccgt ccgttgaggt 471721 gcaagagcac tatcgcatga acgcgaaaga attgctcatg gccgcttcta cctccggcgg 471781 aatcggagtc attatctccg ctgtatttgc acttatttcc cagcttgatg aagtgctgcc 471841 gatggattgg ttattcgata aattttcctt ccttcagcac gccagcatcg gtatttatgc 471901 ggtactcatt tttatcggtt tatttatcgc ctggattttc agcatcgcgg gcatgatgtt 471961 tagatacgcg aactttcaaa tcataaaaaa agagcaggaa ctggtgattt caaggggaat 472021 tattgaaaaa catcaagtca cgattccgct gcgaaaaata caagccatta aaatcaaaga 472081 aaatatcatt cgccagcttt tcggctttgt aacggtgtcc atcgtcagcg caggaggcgg 472141 cgaccgggaa aaagaagaag gcgctttgac cattctcttt ccaatgattc ataaaaaaaa 472201 gcttccgcac atgctccgaa catttacgcc ggaatacacg ctggaagaaa actgccgccg 472261 cctgccgcgg cgcgcgttga aacgctattt gttccgttct gtcatttttt cactcttttt 472321 gatcatcccg ttatgtatct tctttcagcc atggggctat ctgtcagtga tcctgctgcc 472381 gatagaattg ctcttcggct atctcgcgta taaagaggct gcatggacga tcaacgggga 472441 ccgtcttcag ctgacgtcta gatttatagg cagaacaacc gccattgtac tgaaaaaacg 472501 aatgcaggtc tgcaagttca gccaatccta tttccaaaag aaaggccgct tgtataccat 472561 ttctacttcg gtgaaatcat cgagccatat ggaagagtta acggtgaggg acgtaggtga 472621 agaggatgca gccttcattt taaagtggta ctcatatgaa aaagcggacg gttaataccg 472681 ccgctccagc gtgtcggcaa accctcgcat tcgttgtcag gactgcgctt cggtgctcaa 472741 tgcgaagtgg atcaacggct aaattctcag gcgtcctgcc taaacgccgt cgtcatcaca 472801 tcctgtgaaa gtccgctcct atgctcgtcc ttcctagact tcatgggttt tcaatcacgc 472861 tgaaaagatg acaaaatcct aaaatgaaaa ccattttagg attttgtcaa caatctgaag 472921 cggcggttaa taccgccgct cttttttttg cacgcataaa aacgaaagaa gaaacccgcc 472981 gcatagtcca aacaaatggg ccatcatgtt aatattggag ttgataaacg acatgagaac 473041 ggcaaatgcg agcagtgtga tgatcatttt ggaatgctcc tgcccaatta actcattgcg 473101 aaaaagaacc ataaacaggt atacgccaaa tagcccgaaa atggcgcctg aagccccgac 473161 atgcacgtaa tcaagcggct ctgtaacata agtgccgata ttgccgatga tgccggagcc 473221 ggcgtataca agaaggaaac gcgcttttcc cagcatgcgt tccaaagccg gggcaaataa 473281 aaagatggac atggaattaa acagcagatg tgtgaaaccg gcgtgcagca aaatcggtgt 473341 gataagccgc caccattcac cgtttgcgac acctagatta tagcctgtga cggtatccct 473401 ccataacacg actgaatggg caggaagtga aaaaaacagc cagagaacag cttgcaaagc 473461 caatataaag gtgacaacgg ggtaaagcct gataaatgtt tgaaaatttt cagtccgtat 473521 aaacattccg agcccctttt cttcattttg gtatatctat agtaacacgt ttatgagaca 473581 aaccatttaa atagtacgta cgcaaaggag gttatcatac atgatttacg gcattgggct 473641 ggacattacc gagcttaaac ggatcgcctc tatggctggg cgccagaaaa ggtttgccga 473701 gcggattttg acgcgaagcg agcttgacca atactatgag ctttcagaga aaagaaaaaa 473761 cgaatttctc gcgggcagat tcgcggcaaa agaagcgttc tcgaaagcat ttggcaccgg 473821 cattgggagg cagctcagct ttcaggacat tgaaattagg aaagaccaaa atggcaagcc 473881 ctatatcatt tgtacgaaac tgagccaggc cgccgttcac gtatcgatca ctcatacaaa 473941 agaatacgct gccgcgcagg ttgtgattga aaggttgtca agctagtctg catattaggg 474001 aaaccccact catatatttg atagtgcatt aagggagaca agttgtttga ggcttttatg 474061 gtacgcatct gttctgccta aacgtgtacc gagcgtaccg ttaaagtcaa acaagcgatt 474121 tcttcctttt acatcaattg agaaaaaggg gttgaaaaag gtgagaaaaa gctttgtttt 474181 gcttttaacg ggactgcttg ctgttcttat tctttctgcc tgcgggcaaa aaacacagca 474241 agatattgtg gccgggttag atgaaaaggc gaaagaatac acctcgtaca aagcaaaagc 474301 gaaaatgacc atcgagacag ggagtgagcc tcaagtatac aatgtggaaa tctggcacaa 474361 aaagccgtct ctgtacaggg tttatttaga aaatccgaaa aaggaccaaa accaagtcat 474421 tttacgaaat gaaaacggag tattcgttct cacgccgtct ttaaataaga gcttcagatt 474481 tcaaagcgat tggccgaaca acagcagcca ggtttatctg tttgaatcgc tcgtaaagga 474541 tgttcaaaac gattcggatg cagttttcac agcgaaagaa aagaaatacg tatttgaaac 474601 aaaaacaaac tatcagcata acaaaatgct gcccacgcaa gaaatcacat ttaacaaaaa 474661 agatatgagc ccgtcatctg tcaaagtgat ggatactgac cggaaagtga tggtcaaagt 474721 agaattcagc agctttgaat ttaataaaca atttgataaa gaatcatttg atgaaaagaa 474781 aaatatgacc ctttctcaaa tggatgtcgc cacaagcgca aagccttccg atacatttgc 474841 ggtcaaaacg ccgctggaac tgccgcttgg cgtcaagctg cttgaagaaa aagatatatc 474901 tactgaagac gggaagcgca tcatcatgac gtacggagga gaaaaatcat ttacgttaat 474961 tcaggaaaaa gcccagattg ccaaggcttc ctcctccgtt acgctgaacg gcgaaccggt 475021 aaatctcggc tacaccatcg gcgccctgtc ggatgcatca ttatcatgga catatgacgg 475081 cgtagattac cttctctctt ctaaagatct ttctaaagag gaaatggtga cagtagcgaa 475141 aagcatgcag ggacaatcat cgaaataacc gccaaaggcc aaacatgatt tggccttttt 475201 ttcgttagac atcgtttccc tttagccttt aattttagta tgatatgtaa atgatattga 475261 ataaaagcta ggaagtgtcg taatgagcac aaaacctttt tacagagata cgtgggcgga 475321 aattgacttg tccgcgataa aggaaaatgt cagcaatatg aaaaaacata tcggtgaaca 475381 tgtccacttg atggcagttg tgaaagcaaa cgcctacggg catggtgatg cagaaacagc 475441 aaaggctgct cttgacgcag gtgcttcatg cttggccgtg gccattttgg atgaagcgat 475501 ttcactgcgc aaaaagggat tgaaggcgcc tatattggtg cttggcgcgg ttcccccgga 475561 gtatgtggca atcgctgctg agtatgacgt gaccttaaca ggttattctg ttgaatggct 475621 tcaggaggca gcccgccaca cgaaaaaagg ttctcttcat tttcatctga aggtcgatac 475681 ggggatgaac agacttggtg taaaaacaga ggaagaagtt cagaacgtga tggcaattct 475741 tgaccgcaac cctcgtttaa agtgcaaagg ggtatttacc cattttgcga cagcggatga 475801 aaaagaaaga ggctatttct taatgcagtt tgagcgcttt aaagagctga ttgctccgct 475861 gccgttaaag aatctaatgg tccactgcgc gaacagcgcc gctggactcc ggctgaaaaa 475921 aggctttttt aatgcagtca gattcggcat cggcatgtat ggccttcgcc cgtctgctga 475981 catgtcggac gagataccgt ttcagctgcg tccggcattt accctgcatt cgacactgtc 476041 acatgtcaaa ctgatcagaa aaggcgagag cgtcagctac ggagccgagt acacagcgga 476101 aaaagacaca tggatcggga cggtgcctgt aggctatgcg gacggctggc tccgaaaatt 476161 gaaagggacc gacatccttg tgaagggaaa acgcctgaaa attgccggcc gaatttgcat 476221 ggaccaattt atggtggagc tggatcagga atatccgccg ggcacaaaag tcacattaat 476281 aggccggcag ggggatgaat atatttccat ggatgagatt gcaggaaggc tcgaaaccat 476341 taactatgag gtggcctgta caataagttc ccgtgttccc cgtatgtttt tggaaaatgg 476401 gagtataatg gaagtaagaa atcctttatt gcaggtaaat ataagcaatt aacttaccta 476461 aatggagaat tcataaaaca gctttgcttg aagagtgaat aatggtatca ttatcactgg 476521 atggataaaa gagtcgtatc cgtaagtttg gtggaggtgt atgttttttg tctgaatcca 476581 gcgcaagaac cgaaatgaaa atcagcttgc ccgaaaacct agtagctgaa ttggatggtg 476641 tagcgatgcg ggagaaacga agcagaaacg aactgatatc acaagcagtg agagcgtatg 476701 tcagcgaacg aacaactcgt cacaaccgtg atttgatgag acgcggctat atggaaatgg 476761 cgaaaatcaa cctgaatatt tcttctgagg ctcactttgc ggagtgcgag gctgaaacga 476821 cagttgagcg cttagtcagc ggaggataat catttgattg tgaaacgcgg cgatgtttat 476881 tttgctgatt tatctcctgt tgttggctca gagcaaggcg gggtgcgccc ggttttagtg 476941 atccaaaatg acatcggaaa tcgcttcagc ccaactgcta ttgttgcagc cataacagca 477001 caaatacaga aagcgaaatt accaacccac gtcgaaatcg atgcaaaacg ctacggtttt 477061 gaaagagatt ccgttatttt gctggagcaa attcggacga ttgacaagca aaggttaacg 477121 gataagatta ctcatctgga tgatgaaatg atggataagg ttgatgaagc cttacaaatc 477181 agtttggcac tcattgattt ttagacatat ttgcaggttg ctcaaataga gcaacttttt 477241 ttgttttcaa aaaacataaa cgatataata gtgaaataac gaaaaaatat gttgtttttt 477301 attgggaggt aagcgaattt gatgtcgaac cagactgtat accagttcat tgccgaaaat 477361 caaaatgaac tgctccaact gtggactgac acactaaaag aattaagcga gcaagaatcc 477421 tatcagctga ctgaccaagt gtatgaaaat atatctaaag aatatatcga cattctgctg 477481 ctgtctgtta aggacgaaaa tgctgctgaa agccaaatca gcgaactggc gcttcgagcg 477541 gtccaaatcg gactgtctat gaagtttttg gctactgcac ttgccgaatt ctggaagcgt 477601 ctctacacga aaatgaatga taagagattg ccagatcaag agagcacgga attaatctgg 477661 cagattgatc gctttttcag cccgattaac acagaaattt ttaatcaata ctcaatctca 477721 tgggaaaaaa cagtatccct gcaaaaaatc gcgctgcaag agctgtctgc gccgcttatc 477781 ccggtgtttg aaaatatcac tgtgatgcct cttgtcggaa caattgatac cgaacgcgcg 477841 aaacgaatta tggaaaacct tcttaatggc gtcgtcaaac accgttccca agtcgtgctg 477901 attgacatta caggtgtccc tgtcgtcgat acgatggttg cccatcatat tattcaggca 477961 tcagaagctg taaggcttgt cggagcaaaa tgcctgctgg ccggaatccg tccggaaatt 478021 gctcaaacaa tcgtcaacct ggggattgat ttatcccaag ttataactaa gaataccctg 478081 caaaaaggaa ttcaaacagc attggaaatg acggatcgaa aaatcgtttc attgggggaa 478141 taacattttg agacatccga aaatcccgat cttgaaactg tataattgct tattagtgtc 478201 cattcagtgg gaacttgatg accagacagc attaactttt caagaagact tattaaataa 478261 aatatacgaa acaggtgcta acggagtcgt cattgacctg acatctgtgg atatgattga 478321 ttcatttatc gcgaaagtgc tgggggacgt cattacaatg tctaagttaa tgggggctaa 478381 agtcgtcttg accggcattc agcccgctgt ggcagtgacg ctgattgaac ttggaatcgc 478441 gcttgaggaa atcgaaactg cgctcgactt agagcagggg cttgagacat tgaagcggga 478501 attgggggaa tagcgaatga acgaccaatc ctgtgtaaga atcatgacag aatgggatat 478561 tgtggccgcc agacagctgg gacgaaacgt tgcgaaagaa ctgggtttcg gcacggtaga 478621 ccaggctaga attacaacgg ctatttcaga attagccagg aatatttatt tatatgccgg 478681 caaagggcag attggaattg aacaggtcgc agacagagga aaaaaaggcc tgaaaatcat 478741 agcggaagac caagggccgg gaattcctga tatccgaaaa gtcatggaag acgggttttc 478801 aacgtctgga ggacttggtg cgggacttcc cggggtcaaa aggctgatgg atgaattcag 478861 cttaaattcc gtagcggggg aaggaacaga gatacaagcc atcaaatggc ttcggtagga 478921 ggtaagaacg tggattttag ggaggttatt gagcagcggt atcatcagct gcttagtcga 478981 tatatagccg aattaacaga aacatcttta tatcaagccc aaaaattcag ccgaaaaaca 479041 atcgagcacc aaattcctcc ggaagaaatc atcagcattc acagaaaagt gctgaaggag 479101 ctgtatccaa gtctcccgga agatgtgttt cattcgctgg attttttaat agaagtcatg 479161 attggctatg gaatggctta tcaggagcat caaaccctta gagggataca gcaggaaatc 479221 aaatcagaaa ttgaaatcgc ggcaaatgtc cagcagacgc ttctcggaac taaagttcct 479281 caggaggaag cgctggatat cggcgccatc agtgttcccg ctaaacagat gagcggtgat 479341 tactaccact ttgtcaaaga caaggaatcc atcaatatcg caatcgcgga cgtgatcgga 479401 aaaggcattc cagcggcttt atgcatgtcc atgattaaat acgcaatgga ctctttgccg 479461 gaaacgggca tacacccttc tcaagtgctg aaaaatttga atcgtgttgt tgaacaaaac 479521 gttgatgcca gtatgtttat tacgatgttt tatgcgaatt acaatatgga caagcatcaa 479581 tttacatatg cttcagcggg acatgaaccg ggattctatt attctcaaaa agacaacacg 479641 ttttacgatt tagaggccaa aggactcgtt ctcggcatct cgcaggacta tgactacaaa 479701 caattcgatc agcatctgga aaagggcgat atgattgttt tattttctga cggcgtcaca 479761 gaatgcagaa cggaaaacgg tttcttggag cgtcctgatc tgcagaagct cattgaggaa 479821 catatgtgtt cctctgcgca ggaaatggtc aaaaacattt atgacagcct cctcaaattg 479881 caggattttc agcttcacga tgattttacg ttaattgttt tgcggagaaa ggtttaacgt 479941 ctgtcagacg agggtataaa gcaactagtg atttgaagga aaatttgagg tgatacgaat 480001 gaatataaat gttgatgtga agcaaaacga gaatgatata caagtaaaca ttgcaggaga 480061 aattgatgta tactcagccc cggtgcttag agagaagctc gttcctctgg cagaacaagg 480121 agctgactta agaatttgcc tgaaagatgt cagctacatg gacagtaccg gattgggcgt 480181 ttttgtaggg acctttaaaa tggtgaaaaa acaaggtggt tcgctgaaac ttgaaaatct 480241 ttctgaacgg ctgatccgac tgtttgacat tacaggcttg aaggacatca ttgatatttc 480301 tgcaaagtca gaaggtggag tgcaatgaag aataatgctg attacatcga aatgaaagtg 480361 ccggcccaac ctgaatatgt gggaattata agactgacgc tgtcaggggt cgcaagcaga 480421 atgggctata cgtacgatga aattgaagac ttgaaaatcg cagtcagtga ggcgtgcaca 480481 aatgcggttc agcacgctta caaagaagat aaaaatgggg aagtgtcaat acgattcggt 480541 gtgtttgaag accgtttaga ggttattgtg gcggatgaag gagacagctt tgactttgat 480601 caaaagcagc aggatctagg gccgtacaca ccttcgcaca cagttgatca attatcagaa 480661 ggagggctcg gtctatattt aatggaaacg ctcatggatg aagtcagagt gcaaaaccac 480721 tccggcgtca ccgtagcgat gacaaagtat ttaaatgggg agcgagttga tcatgacaca 480781 accatcaaaa actacgaaac taactaaaga tgaagtcgat cggctcataa gcgattacca 480841 aacaaagcaa gatgaacaag cgcaggaaac gcttgtgcgg gtgtatacaa atctggttga 480901 catgcttgcg aaaaaatact caaaaggcaa aagcttccac gaggatctcc gccaggtcgg 480961 catgatcggg ctgctaggcg cgattaagcg atacgatcct gttgtcggca aatcgtttga 481021 agcttttgca atcccgacaa tcatcggtga aattaaacgt ttcctcagag ataaaacatg 481081 gagcgttcat gtgccgagac gaattaaaga actcggtcca agaatcaaaa tggcggttga 481141 tcagctgacc actgaaacac aaagatcgcc gaaagtcgaa gagattgccg aattcctcga 481201 tgtttctgaa gaagaggttc ttgaaacgat ggaaatgggc aaaagctatc aagccttatc 481261 cgttgaccac agcattgaag cggattcgga cggaagcact gtcacgattc ttgatatcgt 481321 cggatcacag gaggacggat atgagcgggt caaccagcaa ttgatgctgc aaagcgtgct 481381 tcatgtcctt tcagaccgtg agaaacaaat catagacctt acgtatattc aaaacaaaag 481441 ccaaaaagaa actggggaca ttctcggtat atctcaaatg cacgtctcgc gcttgcaacg 481501 caaagctgtg aagaagctca gagaggcctt gattgaagat ccctcgatgg agttaatgta 481561 atgatccagg ttgaagaaaa cgagcatatt caaactctag tatatcaact gaataaagaa 481621 gggaaatcga tttgcggtga cagttttttt atgaaagctg atgataagga gttaatttgc 481681 gcggttgctg acggactggg aagtggatca cttgctaacg aatcctctgc agccatcaaa 481741 gacttagtgg aaaactatgc gagtgaagac gtagaaagca ttatcgaacg ctgtaatcag 481801 gcgatgaaaa acaaaagagg cgctacagca tctatcctga aaatcaattt tgagcaaagg 481861 cagtttacgt actgctctgt cggaaatgta cggtttattc tgcattcccc gtctggtgaa 481921 agcttttatc ctctgccgat ttcgggctat ttatcaggca agccgcaaaa atacaaaacg 481981 cacaccgcca cctatgaaaa gggttcaaag ttcattatac atacagatgg actcaacgta 482041 cctgatatcc gctcccattt gaaaaaaggc caatcggtag aagaaatatc gaattcgctg 482101 aaaatgtata cgacatcgag aaaagatgac ctgacctata ttctcggaca gctgtcctaa 482161 aaaaccagaa aaagaagctg gacatccggc ttcttttttt tgcggttgac tattaataag 482221 tgcgcttatt atacttaata agtgaactta tcattctggg agcttatggg atgtggaatt 482281 atgaatacac agcgatagct gatgtggatg tgggaaaacc tggaactgtt atcaggaaac 482341 agaaacaatg gatcaatggg agacgggtat tgcatcagat tctttgaaag gacaatttca 482401 aaatggaacg gaaggaacat tgcttctgca aggaaaaaca attctcttat ggcttgagca 482461 tgtggagaaa catcgggcgt tttctgtcat ggtcaacatg cccgcatagc aatgtaataa 482521 tggagttttt tcacgtgctt caaaagcaaa aagaagattt gtgtatcaca tatggaattg 482581 tattagaagg cgctgaagca aaaaagtggg gagaaatcat tgggactgaa ctgtctaaag 482641 acatgccgac ggctgtcagc aggcttgtcc atctttacgg aggagtgata aaatgaacac 482701 aaattactgg atcggcgttg tgtcagagca acatgtatta aaaggcgctg ccggcggttt 482761 tgcacagctg tgccatggaa aaaaagcccc gctcgccaaa atgaaagagg gagattggct 482821 gatttattat tctccgagag acgcatatcc agacggcaaa ctgctgcgaa gctttactgc 482881 gatcggcaaa gtaaaaagcg gaaacatcta tccgtatcaa atggctccga attttattcc 482941 ataccgatta gatatagact attatccatg ccataaaatc ggtttttacg acattaaatc 483001 aaagcttgaa tttgttcagg aaaccaagca tcttggcttt ttatttcgca gaggacactt 483061 tgaaataagc aaaaaagatt ttttgacaat agcacaagcg atgggagtta acataagtgg 483121 aatggcactc taaatttagc ggtccgaaca caagcccggg ctttttatta tggcaggcca 483181 cgcaaagttg gcagcggaaa gtaggaaaag cattggctga gtttgacctg acccacgttc 483241 aatttgttct gctgacctcg tgcaagtata tgattgctca cggagaaacc gtcacgcaaa 483301 aaaaacttgc aagcttcagc cagaccaata tcatgatggt ttcggaggtt gtgcggacgc 483361 ttgagaaaaa aggatttatc gaaagaagca aaaatcccca ggataaaaga gaggtcctcc 483421 tgtctcttac agaaatagga ggagaaaaag taacagcggc tttgccaatt gttgagaaga 483481 ttgatcaagc cttctttgca gctgcgatga aaaaagagaa ttttctgagc ggcttacagg 483541 aactattgaa acatgagtaa agatacgggc agcgccagct gtcttttttt atgtgttttt 483601 ttcggttttt gatacactag agaaagaacg acaaaattgg aggctttggt tacatggaaa 483661 cgtcagccct tttaaaacag caaattgcga aagaaatagg tttatcacaa aaacacgttg 483721 aaagtgtcat ccgcctgctt gaggacggca atacagtccc gtttattgcc cggtatcgaa 483781 aagagcagac gggttcaatg gatgaggttc agattcagac gatttctgaa cgctggcaat 483841 acatacaaaa cctgaatcag cgaaaagaag aagtcatcag gctgattgca gagcaggata 483901 aactgacaga taatctaaaa cgtaaaatcg agcaatcggt gaagcttcag gaagtggaag 483961 acctttaccg cccttataaa caaaaacgta aaacaaaggc gacagtcgcc aaaagcaaag 484021 gccttgagcc gcttgccgac tatatcctga cacttcccca agatgatcat ctggcagcaa 484081 ctgcagacca atacatcagc gaagaaaaag aagtgttcac acgagaagaa gcgattgaag 484141 gcgccaagca cattattgcg gaacaaatct cagacgagcc gaccttcaga aagtggattc 484201 gccaggaaac cttcaaaaga ggaaccatta agtctgcagc cggaaagtcg gcagacaccg 484261 atgagaaaaa tgtgtatgaa atgtattacg agtatgaaga gccaattgca aaagttgttc 484321 cgcatagggt gctggcaatg aaccgcggcg aaaaagaaga cattttaaag gtagcgatcg 484381 aaccgcctgc ggatcacatt aaggcgtatt tagaaaaaca aatcatcaaa aatcgctcaa 484441 catccgtaag agagattttg caggagacaa ttgaagacag ctataaaagg ctgatccagc 484501 cggcaatcga gcgtgaaatc aggaaagagc tctcagaaaa agctgatgaa caggcgattc 484561 atattttctc agagaacttg agaaagcttc ttttgcagcc gccgatgaaa ggcaaaaccg 484621 ttctcggtgt tgacccagcc tttcgaactg gctgtaagct cgctgtgtca gatgagaccg 484681 gaaaagtctt gaaaattgat gtgatctatc cgcatgcgcc agtcaacaaa acaaaagaag 484741 cccatgaaaa agtgaaaaag attcttgagc agtatcaagt cgagatggtg gcgatcggaa 484801 acggcacagc atccagagaa acagagcaat tcatcgtcaa tgtactcaga gacatgccgc 484861 gcaaaattta ttatgtgatc gtcaatgaag cgggagcaag cgtctattcg gcttcagagc 484921 ttgccagaga agaattccct gaccttaagg ttgaagagcg cagtgccgta tctattgctc 484981 ggagacttca agacccgctc gcggagctcg ttaagatcga tccgaagtct gttggtgtcg 485041 gacagtatca gcatgacgtc agccaaaaac gcttaaatga atctctgcgg tttgtcgtcg 485101 aaactgtcgt aaaccaggtt ggagtaaacg tcaacacagc ctccgccgcg ctgcttcaat 485161 atgtagctgg attatcgaag tctgtagcag gcaacgttgt caaaaaacgt gaggaaatcg 485221 gaaagttttc aaatcgaaaa gaactgaagg acatcccaag gttaggtgcg aaaacctatg 485281 agcaatgtat cggtttctta agagtgcagg aagggacaga gcctttggat agaacaggca 485341 tccacccgga aagctataaa gaaacaaaag cacttttgaa aaaactcgga ctttcaacag 485401 aacatatcgg cacggcggaa ttgaaggaca aaatcaatca gctggcgctc tctgaaacgg 485461 caaaagagct gggaatcggc gaaatcactc tgaaagacat ttgtgaacag ctgacaaggc 485521 cggaacgcga tccacgcgat aaggtgccta agcctttgct gaaaacagac gtccttcagc 485581 tggaagattt gaaagaggga atggaactgc agggcaccgt gcgcaatgta gtggacttcg 485641 gagcgtttgt tgatatcgga gtcaaacaag acgggcttgt gcatatctca aaattgagca 485701 atcaattcgt caagcatcct cttgatgtcg tatctgtcgg cgatattgtg acagtttggg 485761 ttgacggcgt agatgtacaa aaaggcagag tatcgctgtc tatggtaaaa taaaagcact 485821 gcttacgagc agtgtttttt cctatagaaa taccagcatt gattcagcag tttaatttgg 485881 taattatctt tttcaaggaa cgctttttgc atctgctttt taagccaatt tggcataggc 485941 tcattcctcc tcagctttta tcataagagg gacagtgatt accatattgt atgcgaacgg 486001 tgaattgtcc cgttcaatgt tttttaagtg aggtgcacca tggataacaa agagcttcaa 486061 aagctgacag aggatatttc tgaaacatat tttaaaaagc cgttccgcca tcaggcgctt 486121 tttaatgacc ggcttaaaac cactggcggc aggtacctgt taacctccca taacattgaa 486181 ttgaacagaa aatatttgat tgaacacggc agggaggaac tgattggcat catcaagcac 486241 gagctctgcc attatcatct tcatcttgaa ggaaaagggt acaagcacag agacagagat 486301 tttagaatgc tattgcagca ggtcaacgcg ccgaggttct gtacacccct taagaaaaaa 486361 gcggaaaaca aaaaaactta tatgtatatc tgtacgacct gcggccaaca gtatataaag 486421 aagcgcgcca tgaaccctga cagatacaga tgcggaaaat gccgcggaaa aataaaaaga 486481 attttttcgt gaaaaaggtt gacgaatatg gcaagcctat gttacattat aaaagtcgtc 486541 acgagagata aataaaaaca tttacctctt gacactgcaa atcaaggctg atataataag 486601 tcttgtctca ttattccaca gtagctcagt ggtagagcta tcggctgtta accgatcggt 486661 cgcaggttcg aatcctgcct gtggagccat attggagaag tactcaagtg gctgaagagg 486721 cgcccctgct aagggtgtag gtcgcgtaag cggcgcgagg gttcaaatcc ctccttctcc 486781 gccataagat ttcgatataa gttctcaacc atcggcccgt tggtcaagcg gttaagacac 486841 cgccctttca cggcggtaac acgggttcga atcccgtacg ggtcattcca tttcgttggg 486901 ctatagccaa gcggtaaggc aacggacttt gactccgtca tgcgttggtt cgaatccagc 486961 tagcccagcc atttttattt ttgaaatcta atagtaagag ccattagctc agttggtaga 487021 gcatctgact tttaatcaga gggtcgaagg ttcgagtcct tcatggctca ccatttgtct 487081 ttttgcgggt gtggcggaat tggcagacgc gctagactta ggatctagtg tcttacgacg 487141 tgggggttcg agtcccttca cccgcacttt atttacaaag tgcacgcaaa tctgttttac 487201 taggttaaga gcctactaaa ccagcacaac acaatttaat gatcacgcgg tcgtggcgga 487261 atggcagacg cgctaggttg agggcctagt gggtgaataa cccgtggagg ttcaagtcct 487321 ctcggccgca tctcaataat accaagggtt taaccacctt tggtattatt tttttgtgtg 487381 gaaaatacgg ctatgggaga agacttgctc accaaaactc accagttact taaagtaagt 487441 catccaaacg gtcggcggtt ccttctgttt attaggaaaa agatatccgt tcattgtaaa 487501 agaaacgaac catgtcctat tcgttcaaaa aaactaaagg gtgatacata ttatacatga 487561 ttaatatgta tcaccctttt ctttcttgtt caacaatcgc gcttgaggag aacataagct 487621 aatacaactg actcgatttc taaagttgct ccattctttt tttaaacaac tcatccacaa 487681 cctgttttaa aatctcgtac gactgaattt ccttgctcaa ttcgtaaata ttagataaca 487741 caattaattc atctgcgtga tacatttgtt ggaaatcaat tagttcgcga cgaattgttt 487801 ctcgatcacc catgattgta taccccagtc gactgtggag aatttctaat tcaaactgtg 487861 ataacgattc taggaagttt tcagtgggtg gaataagctt acttaaatta tttgtataaa 487921 tatcaatata cacctgcaaa tgacttgcag aaataaaaga tgcctcgtct atagattctg 487981 ctgcaatcac attaatgcaa gcgatcacat aaggttcttg taaataagaa gacggttgga 488041 aattttctcg ataaatagag agcgcttctt ccatcgaatg gggtgaaaat tgagcgccaa 488101 atgcataggg taaaccaagc tttgcagcaa tttccgctga atccgttgag gatcctaaca 488161 caaaaacagg cacatgcgtt ccaatacccg gataagcgcg aacctcaccc tgtacactct 488221 tatccccgac aaaacgcaaa atatcattta cttctctttc aaagaaaaac actccattat 488281 ggttggaacg acgaatcaca tcggccgttt tttgatccgt tccgggtgcg cgtcctaatg 488341 ccaaatctac acgatttgga tataatgttt caagtgttcc aaattgctcc gctacgatta 488401 atggggaatg atttggcaac ataatacccc ctgaacctac gcgaatgtct tttgtatttg 488461 ctaatatatg ttgtacaatt gatacggttg ctgcacttgc ataagcgtcg tgattatgat 488521 gctctgcaaa ccaaatccgt ttatagccca tattatctac agctttagct aatgacactg 488581 cagaatcaat cccttgtttc attgtttctc cttgtcttaa tggagcaact gataaaacag 488641 atatatcaaa ttttttcata atttcacctc taaaataatg aacttataca agatcaatgg 488701 aaaaaacatt ttgaaaaatt gtttcatatt aaatggtgtc cattcctctt tgatttgcat 488761 gcaaataaat atatactttc tcaaacgatc aatacatagg caaaataaag ttatttcaca 488821 atttcacttt acttttaaag ttttaagcaa acataaaaaa atgttcagtg aacaaaatat 488881 gtaaaataca tcttattttt cagaaaggat acaagaaaat gattgatgaa atagataaaa 488941 aaatacttga tgagctgtct aaaaatagtc gccttacaat gaaaaaatta ggggaaaaag 489001 tacatctcac tgcaccagca accgcatcaa gagtagtaaa gttaatagac aatggcataa 489061 taaaaggatg tagtatcgaa gtgaatcaag tgaaattagg cttctctata catgcttttc 489121 ttaatattta tatcgaaaaa atccatcatc aaccctattt agcttttata gaaacacaag 489181 ataactatgt aataaacaat tataaagtta gtggagacgg ttgctatttg cttgaatgta 489241 aatttccttc aaacgaggta ttagatcaat ttttaaatga cttaaataaa catgcaaact 489301 ataaagtgtc gattgttatt ggtaaatagt taactttata aaacggagat gtgcggtcat 489361 ataacatgat atatatgctc taaaaaagcc ctaggttgga tatggaattt accaagctgg 489421 ggccttttta tacattataa taacaagcgc attattcatc agacattaat gaagtattat 489481 aatgcttttt tacttcctta atagacaaat aaagctgata gtttccatac ttcaataaat 489541 cattcagaag gtgatttaaa acttcttgtg aatgaaccgt taccttcaga agataacatg 489601 catctcccga aacacgatga gcttcgctaa tttcattacg agtagcaata aatttcaata 489661 aatcatcatg catatatgca ttcatgaaaa agaagacaaa ggctgtaaaa gaaaacccca 489721 tcttcaattc atcaaccaca atcgaatatg ctttaatgat accgttatcc tccatttttt 489781 tgatgcgatt gcctaccgct tgtcctgtca tatgaatttt ttcaccgatt tctttccatt 489841 gtatccgagc atttttattt aataattgga gaatttgaaa atcaattgaa tcaatttgca 489901 tagtaactcc tttcacagtg aaaaagtttt acaaaatagt atttcatgag accatcgaaa 489961 attcaatgga aattatatat ccttatacag tataaaaatt ttaagaggtg aaaaaatgac 490021 aacagcttta ttagtgattg atattcaaaa tgattacttt ccaaatggga agatggcttt 490081 aacaaaccca gagaaagcag cacaaaatgc ggctaaacta ctttcacact ttagaaacac 490141 aggcgcacct gtctttcatg tacagcatat cacagaaggt aacatcgctc attttttcca 490201 tccaaataca gaaggtgtcg aaattcatga gtcagtacgt ccattagaga aagagacagt 490261 cattgtaaaa catatgccga atagcttttt caatacagat ttaaatggaa agctacaaga 490321 agaaggggtt aaagaattag ttgtttgcgg tatgatgtcc catatgtgta ttgatgcaac 490381 agttcgttct gcagttgaac atggttatgt atgccaagtg gtagaagatg cttgcgcaac 490441 aacaacattg caaattgaag ataaaatcgt tcctgctgag catgtccatt acgcatttat 490501 ggccgcatta aatggtgtct atgcaacagt aaaaaccaca gaggcatttt taaaataaaa 490561 gaatttcctg cgcgaacata acgtctttct tttcacaaga aagatgattc aacaacttaa 490621 aaaaggatgt tcagaaaaat acttctggac atcctttatt cattatcttt tattgttttt 490681 cagtatcatt attcccatct gataaaagat caagatgtcc tgtttttgat ccatagtaag 490741 accatataca gggattgttt ttgccataaa tatagatatt gatgaaggtt tacataaagc 490801 acctaattgc ttgatttact ttaatgttag atccctcaat aactccattc tcttctaatt 490861 tctctactct agctgtagct gctgggcatg ttaaatgtac tctctcccag atctttcatt 490921 gaattcggct attatacata atttctctat aattttttat ctgtttgatc tatttgaacg 490981 ttaattcctt tcgaaaataa agtcaaagag ttaaaacact tttttttatc tatgtattcg 491041 aacactgctg atattataca cttaactctg tcgatctaag acaaataaaa aaagaaagtg 491101 agttgtaaat atgaatatta cacaaattcg aaatgcaaca attgttgtaa aatacgcaaa 491161 taaaaaattt ttgatagatc ctatgttagc agagaaaggt acgtacgcta ctttccctga 491221 aacgatcaga caagatttat ttaatccttt ggtgagtttg ccaacatcaa ttgataacat 491281 tctggatggc gtagatgcgg taattgttac tcatctacac ctagatcact ttgatgatgt 491341 ggcaaaaaac gtattgccaa aaaacatcaa aatgtttgtt caaaatgaag cagatgcaaa 491401 agaagtaaaa gcaagtggtt tcaaaaatgt agaagtgcta catcaagaca ctgtttttga 491461 agggatccaa ttagtaaaaa caaaaggtga acatggcaga ggggaagagt tattaaactt 491521 aatgggtgat gtttgtggat tagtattcaa gcacccaagt gaaaaagttt tatatgtagc 491581 tggggataca gtttggtatg atgctatcga agacgagatt catacacatc aaccagaaat 491641 cattgtggtt aatggtggag acaatcaaag attagattta ggttcactca tcatgggaaa 491701 agaagacatc tatgaagttc acaaggctgc tcctcatgct aagattatat ctgttcatat 491761 ggaagctgtt aaccattgga cactatctag agaagaatta aaaaacttta gtaaagaaaa 491821 aggattctca agtaatattt tagtgccaga agatggcgag tcttacacat tttaatatga 491881 acaccgacaa ataaatagaa gaagctcata attataaaaa ctaatcatga gcttcttcta 491941 ataatgaata ttttaaattt taaatatatc gaaaatccta aatatacgga ataacaaaaa 492001 tggaatgttc caatgatgac aaaaaaactt gaaaagcaac aaagatgtgt cgttaggagg 492061 tagaattcat ggtaatgaca aaaaaagata caaatatatc aacacagcag cctctttggt 492121 tacaaggtta tattgattca ccagaaaaac aaaaccaact ttataaaaaa acattaaaaa 492181 tcttgatttt ttcacaaata tttgggggag caggacttgg agctgggata acagttgggg 492241 cgcttcttgc acaagatatg ataggatcgg aaaatgtagc aggaattcca actgccctct 492301 ttacttttgg atctgccgta gctgccctgc ttataggagc atcctcacaa cgttttggtc 492361 gcagagctgg acttgcaggt ggtttcctta taggcggatt aggtgctata ggtgtgataa 492421 tcgcggcttt aattaacagc gttgccctat tatttgtttc tcttcttatt tatggagcag 492481 gtatggcttc taatcttcaa gttcggtatg ctgggacaga ccttgcaaat gagaaacaac 492541 gggcaactgc tgcaagtatg gccttagttt ctactacttt aggagctgta gtaggtccta 492601 acttagttaa tacaatgggg gaatttgcag attcaattgg tgttcccaat ttagctggtc 492661 cgtttattat gtcaggagca gcttttataa ttgctggaat tattctctta atttttcttc 492721 gtccagatcc gctgtttgta tcaacagcta ttgcgaatgc tgagaaaaaa gacgataaag 492781 tacaaatagg aggaagtcta aaaaatcctg ctatagacaa aaaaggaata atggtaggag 492841 ctgtcattat gattttagct caactaatca tgacagctat tatgacaatg acaccggttc 492901 acatgggtca tcacggtcat ggtttaagcg aagtgggatt agttatagga ctccatattg 492961 cagcgatgta tcttccttca ccattgactg gtttattagt agataagttt ggtcgcacaa 493021 ctatggctat tgcttcaggt gccacacttc ttgccgctgg gttggtggca gctattgcac 493081 cggcagactc attatcattg ctaatcctag cactagtatt actaggggta ggttggaact 493141 ttggtttact aacgggaact gcccttatta tagattcaac acatccatct ctacgtgcaa 493201 aaacacaggg aacattcgat gttttattag cactatcagg agcagcaggt ggagccttgt 493261 caggaatggt tgttgcacat tctagttata caatactatc aatttctgga gccgttttat 493321 cattgttact cattccagta gttatttggt attttagaag gattcaggaa aaagcataag 493381 cttatataac tgtctttgaa gaacctaagt agacattact ttaccggaac ctcctttttc 493441 tatttattat agtaaggagt tgacatggca ttagtggcat gtgtataact acacaattat 493501 ttgggattca gagagcatgt aatgaacgga agagataatt atttatcact tttattattg 493561 tacggtgttc ttgtggcatt aagttcagtc aattttggtc taactgtttt ctttttgttt 493621 tcatcacctc tccatattat taacaaacac gaaaaggatt ttaatgaaaa taaaatgatt 493681 agcgtatgta tctctaattt tcaaaatgaa tgaatagtcc tttttaagat ttacacactt 493741 attctccaag gaaaaatgac tcaatttttc gattttttat gtaaatcaaa aaagaatcat 493801 gttagagtag gtgtgctgaa aataattcaa aaaattattt tgcgatatga ttaaagtaat 493861 attgccagag agtttcaatt ggacaaaatt gtaagtgttt aatacactgg ggctgcaatc 493921 aaatatgcac ctggaatcaa ttgctaaacg ggggagttta tatgaacaac aagaaaaata 493981 tctttgatat tgttatgtac attattttcg gtgtgttaag tctttttcta gttgcaaaaa 494041 ctgattatgg cactggagtt ttagtgtttg ttgcaatttt atacctcgct gttattgctt 494101 ataaaattaa gcaagtattt agtaattcag attcttaagg tgtaacacaa ggaggatttc 494161 aattgagaaa gaaaagagtt attacttgtg ttatggctgc atcattgact ttaggctcac 494221 ttttacctgc aggttacgct tctgcaaagg aggactctaa gacaacccct tcttacgaag 494281 aactagctct acattacaaa atgaaaagtg aaaagatttc atcgaacggg aaattagttg 494341 aaattgagta tgtgagtgga aatgaaactc acaaagttca gatgaacgga aataatcata 494401 ctgtaaaagt cgatggcata gaacaaaaag gtttaaactt tgagtatgat gaaaatgttg 494461 ctaaaagaac aaattatgaa aacaataatt tgaaatcaaa tgaattcaca acacaggctg 494521 caaaacctaa aaagggatac cattatgtgg ggactttatc tgggcataca aaagcagcta 494581 aaaatgcgtt atcagttaca atgtcattag tcggtattgt ccctggcttg ggatggggga 494641 gtaaggctgc cactatttta ttctcttatt gggcaaaaga acaaatccct gatgcgtatt 494701 ataaatatga tttatacgaa aaaggagcaa tgactgatag ttggtatcag tatgctacag 494761 ttcaattttt tgaagataaa gctcataaaa agaaaatggg caaaccttgg acaagtactc 494821 ctgcaaaagt agatttacct aatagctaat tttaaaatca ctttgtcttt ataaaggaca 494881 aagtgatttt ttgttataca gaagtaaaat ccctcgtctg aggaatcttg gaaaaaactt 494941 ggttcaattt tgatataaca tgtttttttc ttgctaattt agtttttcta tgtatcgcta 495001 cacattctaa ataataagat attagccgga cggttgatgc caagctcaaa agtttatatg 495061 gaagtcaaag cataaaaaag ggtgttacaa cgtgtagtct tctttttatt ttgccaacgt 495121 aacaagtgtg aaagtaatga tttgtaggat cagttaagaa aggtttaaga ttagatattg 495181 aaaaatttta tatattttca ataaaatact ggtactataa taaatgtata cagattgtat 495241 ggagatgtaa ttaattaaaa aggagttttt taattgcgtt ggagtaaatg gttcaatgtt 495301 ttttgtatag tagcattggg atcaatatat ggttataaat tatttactaa ccaagaagtc 495361 agtactactc gtttaataat agcttctgta attgtgttgt ggaatattgt tggacttttt 495421 agcaaagaat cagtaaaaca agcacagcaa gcaaattaaa agtcataaag ttgggaaaga 495481 aggatgttac ttatgtagta tccttcttta ttattccttg aaaaatgaaa caaattggag 495541 attacagctt atataatcaa ttgaagtcgt tgattatttt catgaacagg agatttaatg 495601 ctttctgatg aaatattatc gtatgaatgt tgcaagagga aacgttactc aaagattaca 495661 gggatgtgat gaacactcct ctttatcgca ctcacctgac cccaaattgt tggggaaggg 495721 caggtacgga agatagagta ttttttcttc gtaacaaatc gaaaaggttg gataataaaa 495781 aacttataat ctaaggcggt atatagttgt gaaaaaggcg ttatttctta tattagacca 495841 gtatgcagat tgggaaggtg tttacttagc atctgcatta aatcaaagag aagattggtc 495901 ggttcacact gtttctttag accctattgt aagctcaata ggtggtttta aaacatctgt 495961 cgattacata atagggttag aacctgcaaa ttttaatttg ctagttatga ttggcgggga 496021 ttcctggagt aatgacaata aaaaactatt acattttgta aaaactgcat ttcaaaaaaa 496081 cattccaata gcagcgatat gcggtgcagt ggattttttg gcgaagaatg gtttgctgaa 496141 taatcatagc catacaggta attttgttta cttatggaaa gattacaaac aatataaacc 496201 gattagcagt tttgtagaga aacaagcagt aagagataaa aatttggtta ctgctaatgg 496261 aactgcccct attgaattta ctaatttaat tttagagatg attgattttg atactcctga 496321 gaacatagag aaaatgatgt atatgaatcg ttatggtttt tatcattttt gtgataaata 496381 tggaaatcca tttgttgatt aatttgctgg aaatgatttt cccgaatagg gggctttgcg 496441 attgagttga atttcctaat aaagcaaaga aagatgattt gaggtcaagt ttaacaaata 496501 atgccatcaa tattaatttg cagttatttc cgattcctga tataataaag aagaattatt 496561 tttgttcggt gtaaaggata gtatgaagat tgacttttcg tcttgatgat actttgggca 496621 aggatagtat atactgtgtg gttacacact aggaggcaac aaaaatggaa caaggtacag 496681 ttaaatggtt taatgcagaa aaaggttttg gctttatcga acgcgaaaat ggagacgatg 496741 tattcgtaca cttttctgca atccaaagtg acggattcaa atctttagac gaaggtcaaa 496801 aagtatcgtt tgacgttgag caaggtgctc gtggagctca agctgctaac gttcaaaaag 496861 cttaatcttc aatcgtttat acaaacaggc tctttatata gggcctgttt ttttatgtct 496921 atatcatact caataaaaaa ccctactcaa cgttcgagta gggagatgct acaaggtaat 496981 agaaaaagat ttaaaacttc aaaggtttgt ttacagtata acatactgga ttgacaatat 497041 gcggaatgta tataaattat ttaatgtttt gttcaaatat agataactga ctcttttttt 497101 cactaacctg ttcgttcatt taagtaagat tagatgaatt ataaaaatgg tttcatctaa 497161 atgttatcaa ctcgcatatc tcttttatga gaagaagata aacaattatt attcaatgtt 497221 gcagtggata taagaaattc ttaaaaataa tgaggagatc gattgttttt ttctcctgga 497281 aataatcact tagagatacc taaaacaatg aaagccctac ctctcttcca tccttacggc 497341 tccttgtccg tgccagtgtg aatcaggata ctaaaaaaag tgactatttt attgagtttt 497401 ttggtaaaac ttcaatcttc gcagaagaaa tgtaaataat aaaaatggat tagaatgtag 497461 gaataacaaa agaggtcgtt aatgttctaa acataagttg gagaagattt gcttttcatc 497521 ataatattcc gaaatatctt ttgggatgta tctaaccaaa actttttatt tgtttttcag 497581 tgattccttt aattacttcc agttcactaa tcaaaaattc atatgcatta tccagcattt 497641 ttttttcgct tgcattaagt gctttttctt tcttcatacg cattaaatca cgtacaactt 497701 cagcaccttc ttgtatttca cctgttttta ttttgtccgt gtttattttg tacctttgct 497761 tccatggcag taacctatcg gattctccat gctgaaaaat gtgcataatg tgttttaatg 497821 caagtatatc ggtaactggt cgtatattcg aactcaatat tttactcgtt ggaatcataa 497881 ctgtcatatt actgattgac attcttatga cataatactg ttgtttttcc tctaagaatt 497941 ctttttcttc tatggcttca attatacctg ctccgtgcat tggataaaca atgttatcgc 498001 caatttgaaa catatcatcc acctccatat atggtatcct tcttaagatt accatatatg 498061 gaggtgtaat atcaaaattt taataataac atgatcgaat ttttgatgtc aataactttt 498121 ttgaaaaaac agatcaagca aaaacaatag ggaacgtgtc ggatttccaa tcaggaaaag 498181 gtcaattgat ccgtgtgagc agtttttcat tggctcaatg acattacaga aatgatttga 498241 gtagataaga aagaacgata ttcgtgaaat gtcagctaaa aatatttaaa gcacatgatt 498301 aagttctaat ttctttaccg atttgatatg gataacggcc gacttactta atgatgcatt 498361 ttcacttatc ttgcaagcag aaaaaggttt gttgataaac atttagccac caaattggca 498421 ttattatcag ggaaattgac aaccttcaaa tgggtattga ggcgagaaga aaaataaaga 498481 aaggagagat tataaatgaa gaccagaaca taaagaagta aaggggaaag aacaaggtta 498541 attgaaaagc aaactatata aaatagtttg cttttttttg ttatgacttc acttcttttt 498601 ctttctcttt aatgactaat aaaacaccgc tcagaattaa aaacgaacct atccaaaatg 498661 tcccgcctat ttgttctcca agcagaatcc atccgagtaa ggttccaacc agaggctgaa 498721 aaaagaaaaa gaggcctcca cttgaggcat ttaataattg taagccgtgg ttccacaata 498781 aaaatgcaca agctgttgaa acaattccca aatacaaaag gccacctaga attttagggt 498841 caagcagtag tggcgtaaaa atcgtgctag gggagtacca ttaacaggga ctccatttat 498901 taatagaata aactttatga attcattttt ttgtatgata atggcgtcat attcatcgct 498961 tgttgaaatt tacttatgaa ataactggta ctgttaaatc caacttgata agacacttct 499021 gtcacattgg attcagggtg ttgcagtaat aataagcttt tttgaattct ataatccatt 499081 acataacgta atggcgtctt attcagcatt cgtttaaaat aacggcagca ttcagaacgg 499141 ctcagttggc cagcttttgc aatgtcctct aatgtgattt tttcaacata atggagatgg 499201 atccagttta acatttgttt cattcgatga ctttttatca tttcagattg atcgtactct 499261 aattgaaaac cattaacgac caggtttttc cacattaacg ttaattgcat cgtaatgtca 499321 atctcataga gcgatgtctt ttgttgaatc aattgattta tttttttaac agcatctaga 499381 atattttttg cccactgttg atttccagcc aaaaataaat agggcaaatt ggttgaaaac 499441 atatagggct gaacatagct tgaatacagt tcctgagata aaacgaaatg gggtgacaca 499501 ttcaagcaaa tatacgtaca atccgagcct tccttttctt cggccatgtg caggtagccg 499561 ctattgataa ataatccatc cccttcgtga acctctattt tttcttcatt tatttgaaag 499621 agagctatcc cttttagtat caaaacaaat tggatttcat catgccaatg aagcggaata 499681 tagccattta tattttgatt gatcgttgtc ttgtagcagg caactggcaa ttctaccgtt 499741 cggtgctctg ttaattcttt taaattttga tcgatcacaa aattcttcat tctgacttca 499801 cacctcaata tatttatatt ttttcattca atttgagtat tttttatcat gttttgcatt 499861 tattataaca ctattattat atttattagt gaggagtcat gtatgaatac ttccaataga 499921 agaatgggat tgttctatgt tatcacaggg gcgacatgtt gggggattgg aggcacagta 499981 gccaaaaaac tttttcaaga atatcaaatt gatgtcaatt ggcttgtaac gacacgcttg 500041 cttacggctg gaatgttact tttaatgctg caactgttca gaaaggatcg ttcccaggtt 500101 attgaggtgt ggaaacacaa agcgtcggct ggccagcttc taatttttgg cctattggga 500161 atgctagctg tgcagtacac atatatggca tccattcaac atgggaatgc tgccgttgct 500221 acgttattgc aatatttatc cccagtaatc gtcattatct acacgctgtt gcgaaaacaa 500281 acggttctta ccaaacaaga tatcataact gttgtacttg ctttagtggg ttgctttttt 500341 ttgttaacaa atggttcaat gtctcaactt tcagtgccgg cagctgcagt agtatgggga 500401 gttttatcag gattcgcggc agctttttat actttgtatg ccgttggttt attaaataaa 500461 tttgattctc ttgtcgttgt aggttgggct atgattattg gcggttttgc attgggtttt 500521 atccatccgc catggcaact ggattttcaa cgattaactg ctgaggcgta tgcatatatc 500581 ttattcgtga tattatttgg aacaatgatt gcgttctggt tcttcataaa aagcttggaa 500641 agcctctctc caaaagaaac aagcctacta ggcagtctag agcctctatc agctgttgta 500701 acaactgtcg tttggttaaa agcgccattt ggttcttttc aatggattgg tgctatttgt 500761 attataggga taactttaat attggcttta cataaagagc cttctatgga gagtgaaaaa 500821 tcgatattaa agattaggaa tcatgcaaat cgggatatat aggggctttt tttgcttaca 500881 tgaccggtcc ggcaatgaaa aacactggtg gagtttgagc cctctcggca gtatcaaaaa 500941 taccaagggt tttgacgccc taggtatttt ttcttcaaga accttcaatt tttcttctct 501001 gattgaaaaa cgtattactt ttttgtgatt ggtatccaaa tttcactttt aaaagatggt 501061 gatgttacat ccttatgctc gttccacaat atttctggac cttctatttg ttcgtaattt 501121 gacgatggaa accattcgga ataaatgcgt ccccatactt cttgcagtgt atccggaaat 501181 ggcccgattg attcgaatac agcccatgtt gaggcaggaa cttcaagccg tgagaagtta 501241 tctggacacc gtttcgttgt ggctgcgcca atatagtgat cgagctctcc gttttcctct 501301 gtccgacctt cagaaaaatt cgtggatgca ctaatgaggc ctgatggtgc tacattagat 501361 agctctttta gtttatttat tgctttttca tctaaacttt cccacataga tgcaatttcc 501421 ggattaattc ctttgaaaat aataggaact ctttttttaa tgccaacgat gcgaaatgcc 501481 tctttttctt caatacggta gttcatttca tttcctcctt taattgttag ctggaaggtc 501541 attcgtggat aagctttaag ggaatggcca ttaaatctgg cttttgatgg gtttatgcca 501601 tgtaaatttt ggaatgcccg tgcaaaagaa tctggtgagt tataaccgta ctttattgca 501661 atatcaatca cttttacatt gctgtctttc agttcaaaag ctgcaagagt aagacgtctg 501721 cgacgaatat attccgataa tgaaatacct gcaaggaagg aaaacatcct tttaaaatga 501781 tattcagagc agaaagcaag ctttgctgcc tcttgaaaat caatatcatt agtgaggttt 501841 tcttcaatat actttaacgc cctattcata cttttaagca aatccattta tttggcctcc 501901 tttaaccaaa gaataacagg agtgaaatgt atttatccga cattctgtgc acagttttgc 501961 aggatgactt atatgaaata aagtaagtga ttcacttgta tttgtacagg ttttattgaa 502021 gcatgctgtt cataaaaagg catcaataaa agaaagttat aattgtctta taaacggcac 502081 attcatataa ttgagtgaaa aaggatgcgt atcatgccta tcaattcttt tgaaaattat 502141 ccgatgagct ggaagccatc gattgataaa gctgaaaagc ctatttataa agcacttgca 502201 gggcaattgg aacaggatat tttaaacgga gttttattac ctggaacaaa acttcctcca 502261 cagcgagaat tggccgatta tctagattta aatgtgagta cgatttcaaa agcatttaaa 502321 gtgtgtgagt taaaagggct gctgagtgcg actgtaggga gcggcacatt tgtatcgtat 502381 gatgcgttgt cgaatgcgta tttacttgag gatactaagc cgacacattt aattgaaatg 502441 ggagcaatac ttccagatca cgcttcatat gagcccttgt tataccaact gaaaaacatg 502501 gttcatgagg aggattatga aaaatggttt agctatggcc gggcaggtga aagcctttgg 502561 caaaaagatg cagctgtaaa gctcatccaa agaggcggat ttgaaacatc cgttgatcac 502621 attttatttg caaatggagg gcaaaatgcg attgcagcga cattggcgag tctttgtaag 502681 cctggagatc gcatcggagt tgaccatcat acgtaccctg gattaaaaac tgttgcatca 502741 ttgcttagtg tgcaaatcgt accgataaaa tcagaaaacg atgaaatgag tccggagtca 502801 cttgaatatg cgtgtaaaaa cgaaaatatt aaaggtttgt atttaatccc ggattatcat 502861 aatccgacga cttcctttat gtctgttgag aatcgaagaa tggttgcaga cattgtaaag 502921 aaatataatc tgtttgttat tgaggatgca tcgtaccatc ttctcaacaa aaatccgctt 502981 ccggcactcg cctcattcgc accgcaacag gttattcata ttgcaagttt atcaaaatcg 503041 ttagcgccag gcctgcgttt ggcttatgta gcagtgccga gacaatataa ggagccaata 503101 tcaaaggcgc tttataattt aaatataact gtttccccgc tattagctga acttactgct 503161 cgcacgattg tatcaaatca atttgaagtc ttaattgaga gtcatcgtga acaaaccatt 503221 cgcagaaatc aactcgtaaa ccgatatgtt gcgggatata catgtttagg tgttgaaaca 503281 ggcatttttc gttggttgtt gttaccgggt aaaatgtctg gtgccgaatt tgaagaattg 503341 gctgctcgac ttggcgtgca agtgtatgcg gctgaacgct ttgtagtggg aaatagttgt 503401 cctgaaaggg ctgtaagggt ttctgtctgt gcaccaaaaa cacttgaaga gcttgaacaa 503461 ggattaatga tcctgagacg tttgctagac gatcttacct aatattgttt gccatacaat 503521 tatgacattg tatggctttt ttgtgcgtgt tatgatgatc cacatctaga gggaggttta 503581 tacaaaattg gcttttagaa aggaaggtca gatgatgtta gacaaggaca gcgtaaaagc 503641 aatagatgtt caaactgctt cattacagag ctacatcagt tcaccagaaa aacaaaaatc 503701 gttatacaag cgtacactat tcgttgtgag tatctcacaa atttttggcg gtgcggggct 503761 ggcggcagga gtgactgtcg gtgcgcttat tgcacagcaa atgcttggca ctgatgcgtt 503821 tgctggtttg ccttctgctt tatttacttt agggtcagca ggatctgcat taattgttgg 503881 aagactttct caacgttatg gccgtcgaac aggtctttca gctggcttta tgattggcgg 503941 acttggagca ataggcgtta ttatggcagc aatcataaat agtattttct tgttatttat 504001 ttcgttgctt atttacggtg caggtacagc cactaattta caggcccgtt atgcaggtac 504061 agacttagca aatcataagc agcgagcgac tgctgttagt ataaccatgg tttttactac 504121 atttggcgca gtggcaggtc caagcttagt gaatgtgatg ggggatttcg ctctttctat 504181 tggtgttcca tcacttgctg gccctttcat tttagccgca gcagcatata tgttagcagg 504241 tgtggtcctt ttcattatgc ttcgtccaga tccattagtt atagcaagaa caatagaagc 504301 ggcaaatgaa gagcctggtg ataaaggaca tttggcggca actgagcata cagaaaacaa 504361 aaaagggata atcgttgggg caacggttat ggttcttacc caaatagtaa tggtagctat 504421 tatgacaatg acaccggttc atatgagaca tcatgggcat gacttgggtg cagtcggtct 504481 tgttattggt tttcatatag gtgctatgta tctcccttca cttgttacag gtgttcttgt 504541 agataggttg ggacgtaccg caatggctat ttcctctgga acaacgttgc ttttggcagg 504601 tgtaatagca gcatttgctc cgggagaatc tatgattctt ctcgtcattg ctctttcttt 504661 actgggatta gggtggaatt ttggtttgat aagcgggact gcccttattg tagattcaac 504721 tgatactgcc acacgagcta aaacgcaggg gacagtggat gttctgattg cgttgtcagg 504781 agctgctggc ggagcattat ctggaatgat tgtggcaggt tcaagttacc tcgcattatc 504841 acttattgga gggattttgt ccttattact cattccggtg gtggtatggt ctaggggccg 504901 ctaaagggta ggattgttta atttacatta atttgttata ttgttagata aagtatattg 504961 cagcatctaa tattctaacg aactatagtt gctccattaa atctattata aagatttgac 505021 caggattcct tatagctgtg tcactcactg catattcttt aattgaatca cataaaatgg 505081 ttatcggatt tgaaaaaggc aggattactc gctttaggta aaggagtcat aacgttgtta 505141 aaaaggtttt ctcttgttat tgttacacta atgatgtcta tcgttgttgt tttagcggct 505201 gctaaagagt cgcctggaga tcatgtcatc tcatttgatg aacctattat cttgatgatc 505261 tcaattggaa tcgttgtatt tttattgatc cctccattag tcatgtcctt ttttggcaat 505321 ttggttgtaa gaataatatc tggtgtatac caatgtttta tcgttttcac ttttctgggg 505381 ctcattccaa ttggatttct tattcccaat ggctttttga caattctagt ttctattgca 505441 ggaactttag tcagtatagc tagtgttgcc gtaaccttat gcattggcaa gaataaaaaa 505501 gatatataat catcgaattg ttattttttc agattgtcag tgaaataatt atacaaaaag 505561 agaaggcttg tgggccttct ttttttgttg ttgcatcatc cccactttga gcttaatcta 505621 ttgaataata agagaaggaa cctatagaag aataaaataa ataccgagat gtcaaaaata 505681 aaactggact tcattattgt gaattcacgt aaatgtaaaa agattggaaa gaggggaatt 505741 ccttcatgac aaatagcaga acaaatccga aggttgatga atttttaagt aaagcgaaaa 505801 agtggaagga agaatttgag aagttgagaa ccatcattct tgactgtgag ctgactgaag 505861 attttaagtg gatgcatcct tgttacacat atcataataa aaatattgtt ttaatacatg 505921 ggtttaaaga atattgcgcg cttctgttcc acaaaggcgt cttattacag gatacagatg 505981 gaattctcat tcaacaaacg gagaatgtac aggcggcgcg ccagattcgg tttacaaatg 506041 ttcaggaaat aaatgagcta gaaaacattt tgaaagccta tattcacgaa gccattgaag 506101 ttgaaaaagc cggtttgaaa gtggatgtta acaaaaatat tgaattgaac attcctgaag 506161 aacttcaaaa taaattcgat gaaatccctg cattgaaaat tgcttttgaa gctttgaccc 506221 cgggacggca aagagcgtac actctttatt tttctcaagc caaacaatcc aaaacccgag 506281 aatcgagagt cgaaaaatat gtgcaaaaaa ttctcgatgg aaagggatta aaggattagg 506341 cacgccaagg ttcaggctaa aggaatagca tcatagcgta ataagatcat ttctatagaa 506401 gaaaaacaag catagtaaga tgcttgtttt ttcttaggac aacattcact tactgctgaa 506461 atgcttctaa cattgtatgc cactagacag cgttataaaa tattaatgca acacctagaa 506521 atctatccaa tgaaatagct caatggtatg gctcattaca tttagaatgc ctaggagaac 506581 taatagaacc ggaagatttt tagcaagtta ctacactcca aactttgttt ttgtattaat 506641 ataccttatt aaccattgtt tttagtcagg tgcagacaaa cgaatactga ttaatgaatc 506701 atcatgatat caatgagccg cttgattttt tcatcgtcgc ctgtatcaac gtacactgtt 506761 tttctgtttt ttatgatact ctcagtcact tcccgcatga cgcctttttc tatatcatca 506821 gcggaatccc agcgtaaagg cacattatat acatgaattg tgccatcccc attgccatga 506881 taagtgactg atccatccac taaacgagaa cctgccaact gggtcacatt ttctggatag 506941 ctggcacttg tatcatcatt aggattaatt ggctcgccag ccgcaatatg tcgaacattt 507001 aattcatcta tctcttgatt aggtccaagt tgaagccaaa ctctggcata ttcaattttt 507061 tccgaagagt atgctgccaa tacattgtct tctttgcttt tctcttctgc tgaagaggta 507121 tcatttgcag cttttgttgc ggattcttct gattctgtta ttggctccgc ttcatccttg 507181 cgtattttgg tgctctcttc aggctcagtg tgtttttcgt cagtttgcac agcagaagct 507241 tgatttgaag gttgttgtgc ttctccatcc ttactgtccg tacatccagc aagcaaaatc 507301 ataagcagca gggcagtatt gcaataacat atctttctgc gtttcttcat tttttcattc 507361 ctctctatta attcaggtca gcttcatata taagtttatg tatctaaata ttaccatgga 507421 atagatagga tgatattgaa aactgtttaa gaagaggaaa cgatcttgaa tagcatcgcg 507481 aaaacctaag aatcttaaga agttttgccc ctttttcttc aggtattgaa tgtaaagtgg 507541 gatataaatg caaacaaaaa cgaaatgcct tatccacctc gtgtcatggc agaaaaagtg 507601 ggggatttat tagagcggat ttgataatgg cggcaggtaa atgggtgttg acttatatgt 507661 ctaagcggga gactcaagtc tgctcgatcg catacaaaat accaagggcc agcaaccctt 507721 ggtattttta taccttcatg catttttgaa gtttatgctt aaaggtctgc cttactttgc 507781 aaatcgccga gctgctgcaa cgcacatgat aacggcgata ttcactgcta cgagtgccca 507841 gcccactttc tcgtgcagaa tcactgaggc aagcagcagt ccaaaaaaag gctggagaag 507901 ctggagctgc ccaaccgctg caattccccc ttgggcaaga cctcgatacc agaacacgaa 507961 gccaatcagc atgctgaata aggatacata tgcaagactg agcagtgcgg gaacgccgat 508021 cgccgaccat gagtccggcg taaaaaagaa cgacaatggc agcataagag gaagcgacag 508081 aacgagtgcc catgagatca cctgccaatt ccccagacgc cgtgaaagtt tggccccttc 508141 tgcataacca agaccgcata cgacaataga agccagcatg tacgcgtcgc caagcgggga 508201 tgaacctccc ccctgaatga gggcgaaacc tgctactaac aagctgccgg cagctgagaa 508261 aatccagaag acggggcgag ggcgttcacc cccgcgcagt acgccgaaga ctgccgttgc 508321 gagtggaaga agtccaatga agacaatggc gtgtgcggat gtgacatgct gaagcgctaa 508381 agctgtcagc aacgggaaac caatcactac gccgaacgct accactaaca atgaaatgag 508441 atctcttttg gcaggatgct gctgccggaa gatgagaagg agacctcccg ccagtacacc 508501 agctatcgca gcacggcaaa ctgtgagaaa taacggatcg aagtctgaca cagccaaacg 508561 ggtcgcaggc agcgagccgc tgaaaatgag tacgcctata aaaccattta tccagccatt 508621 tgttgttttg ttcattataa tcactccaca tatctttctt gttcattgtc tgtattttct 508681 taacaaaacc agcagctaag gattacaatg actataaact ggaattggcc ttttataaac 508741 agccagtttt cataaaaaaa tgcataccag ttaggagaac aacgcgcaaa tggatatcac 508801 gccttttttg aatagaactc tggatattcc gctttatcag cagctttatc ggtattttaa 508861 agaaaatatg catcggggcc gtattcaaaa aggaatgaag cttccttcaa aaagactcct 508921 ggcgaatcag ctttccatca gccaaacgac tgtagaacgt gcctatgaac agctcgctgc 508981 tgaaggttat attgtgagca agccaagaag cgggtggttt gctgattatc atgattctga 509041 ttttgcttat gatagaatgc caagcacaac acccattcaa caagaagcag aagaaaataa 509101 acaatggatt gattttcatt atgggaatgt agattcttct tacttccctt tttccgcatg 509161 gcgaaaaagc atggtcaata gcttagacca atatggacac gagctttatc ggccgggaca 509221 tgttttagga gagtttgagc tgagaacact cattgcagag tacctgtatc aatctcgggg 509281 ggttcattgc ggccctgaac aagtgattat aggtgccggg aaccctattc tgctgcaaat 509341 cttgtgccaa gtttttgagc cgaatatttc tatagggtat gaggatcctg gttatccaag 509401 agcacgcaag atttttgaag ccaaccgcat gaatattgtt cctataccag tcgatgatga 509461 gggaatctgt atacagaaga tcaaagaaca gcagccaaac cttgtatatg tcacaccttc 509521 ccatcaattt acgctgggaa ccataatgac aataaacaga agaattcagc tgctcaaatg 509581 ggcggccgaa aatcaatcct ttatcataga ggatgattat gacggggaat ttaggtacac 509641 aggacagccg gttccttctc tgcaagggct tgatcagcat aaccgtgtca tttatatggg 509701 cactttttct aagtctcttt tgccctcgct gcgtatcagc tatatgattc ttccttcgcc 509761 tcttttaaaa aagggtcatg aaatcacgtc cttatataag cagacagtgt cctgccacag 509821 tcagctaacc ctagctgaat ttataaaaaa tggagagtgg caaaaacaca tcaacagaat 509881 gagaaaactt taccgcaaaa aaagagccat tgtattagag gcagtgcaaa gggaattagg 509941 agagcatgtc agaatccgcg gagaaaactc tgggcttcgt atcttacttg acgtttattt 510001 gccatttggt gaaaaagagt taattgagaa ggcgaaaaaa catggagtaa aaatttatcc 510061 tgtttctctt tcttatcaac atcatcctcc tacaaaaacg gtctcgctcg ggtttgcagg 510121 ggtttctgaa tccgacataa gagaaggcat aaaaaaactg aaggctgcct ggaagatatg 510181 agggagcttt cagtttagca aaacggccaa gtgacgacta agtgttgaga gctgttcaat 510241 attttttaag tatatgatga gtgcctgcag tccaggccac gatacgtctg tttagcgaaa 510301 aacagaattt tttatttgct cctcacagtg ctaaaataaa caaaatagac aattgaaaaa 510361 atagaggtgt aagaatgaag ttagatgagt ttacaattgg ccaggtcttc aaaacgaaat 510421 cattaaaagt atcaaaagat gatattatgc ggtttgcggg tgaatttgac cctcagtata 510481 tgcatgtaga tgaagaaaaa gcgagtaaag gcagatttaa tggaattatc gcttccggca 510541 tacaaacact ggccatatct tttaaacttt ggattgaaga aggtttctat ggagacgata 510601 ttatagccgg aacagagatg aatcatatga cattcataaa acccgtatat ccggatgatg 510661 aattgtttac aattgttgag gttcttgata agcagccaaa gagaaatgaa ttgggaatac 510721 tcacagtatt gctatctact tataatcaaa aagaagtaaa agtgtttgaa ggtgagttat 510781 ctgtattgat caaacgataa ctcagaaagc ccgcttttcg cgggctcgat tgaagcagat 510841 gggtgaaaga tgttagcggg tttcctttga aaaataagag gttaaaacat cataaacaat 510901 aggcaaagaa gtaaatccct catcttctag aaaatgacct ccgtgctgaa cttcatataa 510961 cgcagcatca atttgttgtg ccagatcctt gctgaatgaa aaaggcacaa tttggtcgtc 511021 cttagaagca atgacagcac ggtgcttcgc ggactcgatg attttttgat gatcaaacga 511081 tccctgtgta aattcatcta acatctgtaa agtgggcaat gatttggcaa agccggaaac 511141 aagtatgatt ccgccaagct gttttcgtaa ttgaagatgt tccaaaaatc tcaaaatggc 511201 ggggcaacct aagctgtgcg caaccaaata cgtattttca tgtaaagtgt gctgatataa 511261 agagagtgta tccagccaat cctcaagtct tggctggagc ggattaggca tgtttaaaat 511321 gtctgcttgg accccatctg cgagcagacg ttttttcagc caagggaacc aatgatttgt 511381 tgaggaggct ctgtagccat gaatgatata gacttgtttt gtcattattt cctcctaaga 511441 aatattttca ttcagtataa aattcctctc attgggaaac aagtacgcac ttttttgtaa 511501 gtagctttac atatgaggcc ctccttgtgc cattccccac ttacacatct catctatgag 511561 gggatacaaa gatcgccctc tgtcagataa cgaatactct actttcagtg gggtgtgaga 511621 aacctcagac cgatgaataa ggccgtcagt ttgcaattcc ttaagctgtg cgcttaacat 511681 tttatgggtg atgaagggca tagccctttt cagctcgccg tatctcatcg ttttttcaca 511741 ccctaactca tagagaattc tcattttcca tttgccccct ataagagata aggtgtattc 511801 aaatggggct tgtttactgc ggcacaggct attcattgta atcaaacctc cttttttaag 511861 tatcatatca gaataaatta ggattttcgg tgttgaagtt tgagggcgat tcacgatctg 511921 aagtgaaagg ggccgcttgc tcaacaggcg gcacggtaca tgaatgttct aagtcaaaga 511981 gggttacctt actgttagtt actttattta aaaaaacgca tgtttttagc tgaaaatatc 512041 tattatggta tatttaaata taaagaaata tttgagaaat gaggaatggt atgaatacac 512101 ccaaaaaaca taagaaattt aaagcgaaaa tgattctcca aatcatcatg gttatcattg 512161 gaggaatcat agcggcatat ggactagaaa cagtgctcat tccaaacagt gtatctgatg 512221 gaggggtgac gggtcttagc atcgttggtt cacagctatt caacttgccg ctggggattt 512281 tgattgctgt gatcaacatt ccatttgtct ggttaggata taagcaaatt gggaaaagct 512341 ttgcattatt atcaattatc ggaatcgtat cgcttgccgc ggggacaagc tttttccacc 512401 acacacccgc tatcatagaa ggagataccc tgttaattac cgttgtcggc gggattatcc 512461 ttggattcgg aatggggctg gcgctgcgta atggcggcgc attagatgga attgacatgc 512521 ttgctgtgct gctatcccga aaactgccat tcggaacgag cgatctcatt ctattcttaa 512581 acctatttgt gtttattttt gtttccacag tatttggctt acaaggggca ttgctttcag 512641 tcattgctta ctacattgca tccaaagtga ttcatgttgt ggaggaaggc ttaagcggct 512701 ctaaaacctt tcaaattatt acaacccaac ctgaattaat ggtagagaca atacgtgatc 512761 aattaggccg aagcgccaca tataaagaag cttacggggg tttttcccac gagaaattta 512821 aagaaatcac atgtgtcatc aaccgtttag aagaaaccaa actaaaggaa attattaatg 512881 atattgataa aactgccttt gttaccgtgt atgatgtagc tgaagtgaag ggcagcaatt 512941 ttagaaatct taatcatcac taaaaaatag aatgaccttt ttaaccgtaa ctgacatgcc 513001 gcgggtaatt taatcaaaaa cacttttttg aggcttgtgg gtgaataacc ggtgaaggtc 513061 tgaatcacag aaataccaag ggcgtcaaaa cccttggtat tttttctggt tattagattt 513121 tatcttcagc tttacgtgct gcttcgagct tatcaatcct gtctttatat ttttctcccc 513181 agtccttcat gtgcaggata acaggttcta atgttcttcc aaactcagtt aaagagtatt 513241 cgacttttgg agggacctgt ttataaacct cgcggtgaat cacgccatcc cgttccaatt 513301 ctcttaattg tagcgtgagc atacgctggg taatttttgg gtatagtttt cgaaactcat 513361 taaacctctt tttaccgtca atgagatgat aaagaagaat gcctttccac ttacctccga 513421 tgatatctaa tgttgtctcc accggacatc cttcaaagtc atcagaagaa taatcaatgc 513481 cgagtttacg atttctcaag ctgttcactc ctaatagtat actttttgat actatataca 513541 ttcaatgtgc gtacttttta tattttaata tacatcatat aatgatgtca catctaagga 513601 atgaaaggaa tggatcatat gaaaacactc gtactcgttg tacatccgaa tatagaatcc 513661 tctcgtatca ataaaaagtg gaaagaagcc gttttaagtg aaccagatgt aactgtccat 513721 gatctttatg aaaaatatcg cgatcaacca attgatgtgg aatttgaaca acagcagctc 513781 ctggcccatg accgtatcgt ttttcagttt ccattatact ggtacagcag cccaccgctt 513841 ttaaaacagt ggtttgatga agtgtttacg tttggctggg ctcatggtcc cggcggaaat 513901 aaattgaagg ggaaagagtg ggtaactgcc atgtccatcg gttcacctga acactcttat 513961 caagccggcg gatataactt gttttcgata agcgagctga caaaaccgtt ccaagcatct 514021 gcccatttag taggcatgac ctatctgcct tcctttgccg aatatcgcgc caatacaatc 514081 agtgaccaag aaattgccga aagtgcgaat cggtatgtaa agcatattac aaatatagaa 514141 ttaaacccga aggttcgcct gcaaaggtat ttgaaacagc tggagagtgt cgatttaaca 514201 taaagattga tttttgaaaa tcctgtactc accaagcagg attttttctt gttcagcaga 514261 gggattttaa catatagcaa aaaaagaaga agccaccaaa aataagctat ttgcttggtc 514321 ctgactgctt atttttggtg aaatacttat ttctctgtga tgaaataaag caaagcgatg 514381 accggaaaag cgattccaat ccataatgct gtactccatc cgcctgaggc atatgcccat 514441 cctccaattg atgaccctat cgcaccgcct agaaagaaga tcgccatgaa taatccgttt 514501 aatcgactgc gaatttcagg cgccaacgaa aaaatagcac gttgactgag cacaaggttt 514561 gcagatacac ccatatctaa cagaatagca gcggccacta gaactgttat accgacgggg 514621 gagctgctct gaatcatgag cggcagtaat aaagagacaa cgacaacacc gagagcgatt 514681 ccagtggcaa gcctggttaa gcctcgatca gccaggcggc cgcctattgg tgcagtgact 514741 gcacccgcaa tgcccaccaa tgcgtagagt gctattgcct tctgagaaaa atgaaaatca 514801 ggaccggaca ataataaagg aacagttgtc cagaacaagc tgaaagctcc aaatacaaac 514861 gcatgataga tggcacggcg gcgtaagact ggagtcgtgc gcagcagctt ccacattgaa 514921 ccgagtaagg cagtatagtt tgtatttgct gttggttttc tggcaggaag cacttttgat 514981 aatacgatgg ccaggataac acttaccacg gcggacaaag cgaatattgc attccacccc 515041 cagatatcag cgactagact agatatcgga cgggaaagca taataccgag taataagccg 515101 ctcatgacat tgccaacaac ccggccgcgt gcagcgtctg atgcaaggta tgatgcaaat 515161 ggaacaagca cttgggctgc gattgatccc aatccgacga aaaacgcagc tgctaaaaac 515221 agtgttccat gcttcacaaa tgctgttagt gtcaaagccg ctgcgcttag aaggagcgat 515281 acaacaataa gttttttgtt ttcgataata tctcctaaag ggacaaggaa tagtaagccg 515341 gcaacgtatc cgatttgggt gagtgtgaca atcaatccag caccgcttgg agaaagtcca 515401 attgccttac taattaatcc gaccaagggt tgtgcatagt aaagattagc aacaatgata 515461 ccgcatgcag ttgcgagaag aagggttaaa ctgggtgaaa tcctctgacc tgcttgtttg 515521 tttccattag ccatatgaat gaactccttt ttaagtggtt ttttgagtgt aatcatgact 515581 tctcacaagt gattttataa actgaacgtt cagtttcgtc gattaataaa aataatatac 515641 taaacgttca gttttgtaaa tggatttctg ttttcttttt ttattcaatt taagtatact 515701 gaacgtatag tttatattgc gggaaggaat gatttatgtg cagagtaaac gagggcggcc 515761 gcgtgatgaa ggaacgcata aggcgattct ctctgcagcc tatgacctat tgctggaaaa 515821 aggcttcgat gcggtgacag tcgataaaat tgccgagcgt gcgaaagtga gtaaagcaac 515881 gatttataaa tggtggtcta acaaggctgc cgttatcatg gacagctttc tttcgaccgc 515941 gacggacagg ctgcctgtgc ctgatacagg gtcgtcagta caagatatag taacccacgc 516001 cacgaattta gctaggtttt tgacaagccg ggaaggaacc gttattaagg aattaatagg 516061 tgcagggcag ttggatgaaa aattggcaga agaatatcgc acgcgatttt tccagcctcg 516121 ccgcctccaa gcgaaaggcc ttctagaaaa gggaattcag aaaggtgaat tgagagagaa 516181 tcttgatatt gaagtaagca tagatctcat ttacggacca attttctatc gtctgcttat 516241 aacaggggat gaggtgaatg attcctatgt gcgtgatttg gtgatgaatg cgtttaaggg 516301 agttcaagct acctctgcta cagagagtat gtagctgata agaactgcaa aagctgcgga 516361 ttatatgaca aattggttcc atcgtacagt gaaatataag atttttgttg ctgagcggaa 516421 tcatcgaggg aaaagttctc ttatcggatg tcgaaaaaga agtcattcaa tcgtgaatac 516481 ataacatcat attattacat tccttttcat cgattggaac aagggttcta tacttcaatg 516541 gaataccgca aagttggagt atttaaacaa caggggaaaa tcgatggcca ttatgtaggt 516601 gtcatggcaa tggaaaaaat acttgcaatg taaacaggcc tctaaagaga cctgtttttt 516661 aatatccaga tgattgtcta gtttcagctt gggctctatg accactccca taactgaaat 516721 agtctaatat ttataccaga agggattgtt tatataaata aaagtttata taatgacggg 516781 ggcgctaagg aaacgcgggg agcgactcag gttttcgttt caaagttttg atccttaaga 516841 tatacggagc gctacatatg gaaacgtaaa ggggaatgta taatcatttg gcgtgtatat 516901 aacgatttgc ttatatattg atttgggaag gaggagctca tatgacgatt gatgttgcgg 516961 cgatgactcg ttgtttgaaa acacttagtg atcaaactag gcttatcatg atgagattat 517021 ttcttgaaca agaatattgt gtctgtcaat tggttgatat gttcgaaatg agccagcccg 517081 ccataagcca gcatttgcgg aaattaaaaa acgcaggttt tgtgaatgag gacagaagag 517141 gccaatggcg ttattattca ataaatggtt cctgtcctga gtttgataca ttgcaattga 517201 tcttacatca aattgatcaa gaggatgaat tgttaaacca tatcaaacaa aagaaaactc 517261 aagcgtgttg ccagtaagga ggcattagat tgacatcaat gattttggca gtattcatct 517321 ttttattaac tctagtattg gtcatatggc agccgaaaaa tttatctata gggtggtcag 517381 cctgtggagg cgcagtttta gctctaatag caggtgttgt caattttcat gatgtgttaa 517441 ctgtgacagg gattgtttgg aatgcgacct tggcttttgt ggccatcata ctgatatcgt 517501 taattcttga taatatcggt ttctttgaat gggcagcgct tcatatggct aaggctgcaa 517561 aaggatacgg tgtgcggatg ttcgtttatg tatctctatt aggagctatc gtcgccgcgt 517621 tatttgcaaa tgacggtgca gctcttatat tgacaccaat cgtattagcg atggtcagag 517681 cattacattt taatgaaaaa ttagtttttc cttttatcat tgccagcgga tttattgcgg 517741 ataccacttc gcttcctttt gtagtaagca atttggtcaa cattgtttca gcggactatt 517801 ttcatattac gtttattgat tatgcatcca gaatggttgt cccgtacctg ttttcgctgc 517861 tggcgagcat cattgtactt taccttttct ttagaaaaag cataccaaaa cgctatgatc 517921 tgactgaggt taaaaaacct gttgaagcaa ttaaagatca aaacatgttc agactgtcat 517981 ggtatatctt agggctgctg ttaattggat attttgcaag tgaatttttt tctatccctg 518041 tatcagtggt agcgggcagc attgcaatca ttttcttaat cgctgcgcaa aagagtccgg 518101 ccgtccatac aaagaaagtg gtgaaagagg cgccatgggc tatcgtattc ttttcaattg 518161 gcatgtacgt tgttgtgtat ggtgtccgaa atgccggatt aacggatgtc ctttcagatg 518221 tgattcaagc cgcagctgat caaggattgt ttgctgggac aattggaatg ggctttattg 518281 cggcgattct ttcttccatt atgaataact tgccgactgt tatgattgac gcattggcca 518341 ttgccggtac agatacacat gggatgatga gagaagcgct tatttatgca aatgtgatcg 518401 gttcagattt agggcctaaa ataacaccga ttggttcctt agcgacatta ttatggcttc 518461 atgttctttc gcacaaaggt atgaagattt cctggggcac gtattttaaa acaggaatta 518521 tcctcacgat acccacttta ttgatcacac ttgtcggcct gtatatttgg ctgctgataa 518581 tccattcttg tttctaaaag gacaaggtca ctatatcaag gaaaacaatg cactggtaac 518641 tcttgccgca gccaaatggc tgaagggtgg gggagaaaat accttggggc taagtggaat 518701 gtgtacagcg caggaatcga agctcaagga tgacatcgag tgctgtcaaa gcaatgaaag 518761 aagcagggat tgatatttca aatcaaacat cggagaaatt tgatgatccg gcaaaagcac 518821 acggaacaga agaagtgttt ccaaagggtc cgtgatgaaa ttggtgaccg tttaaaacag 518881 tttgctgtaa ctggggaata aagaatcgat atattcagcg ttttcttggg ttatataata 518941 caatgtgttg ttcaacaggt gtctgcgagc tgagtgcaga cacctgtttt tgtttttatt 519001 tgtctgagat tcgtaacagg gaagttattt agctggtgac agaggaaaat tgatttgtga 519061 acagaatcat gaaggagacg gtgttttaaa ggagttgtct gttttgcagg aattaacaaa 519121 aaaaaaatac agtagcttaa aaacaatgtt tgatgacaaa tattgtccca catttgtcta 519181 ttcaatatta gaccaaacca ttccgggagc tgtttatgca gatgatcaaa cctttcctaa 519241 atcgtttttt ataggaactg aatcaggcat ttattttatt gcgggagacc aagggaatcg 519301 ggattttcat gatttcattg caggatatta tgaagaacaa gtgaaatcat caaaacgatt 519361 taccttgttt tcttccagtg atacatggga tagcgtactg aaacccatac tgaaagatga 519421 cttaaaccaa atgagaagag ctgcattttc ttatcaacca aaatctttca aaaagacttt 519481 gcaactgcca aaggggcttg tattgaaaag aattgacgaa gacatcattt cacatagcac 519541 agcgtttaac agcgcgtatt atgaggagta ttggaattct gtctcacagt ttgcttcaaa 519601 aggttttgga tttgccgtat tacatggcaa tcacgtagta agtgagtgta cctctatatt 519661 tttagggcat aatcgagcgg aaatggatat ctatacactt gaagaatata gaggactggg 519721 gttagcttat tgcgtagcaa ataggtttat agcgttttgt atggaaaatg ggattgttcc 519781 tagctgggat tgtgatattt gcaacaattc gtccattgca ttagcagcta aactagggtt 519841 taagacggta acggaataca ctatttacta ctctggctaa ccttaatgaa agaaccttaa 519901 aaggagatac caaccgatgt tggtatcttt tttgttttag agttttttta cccttttagc 519961 agaaaaatgg gtgatgaaaa tcttattcat tttatttact tttaggtagg taaaacatac 520021 cccgccaact gtaaccactc cgcctagcag agagagcagt gtgggtatct cgccgatcca 520081 gagccaagat atgatcaagg ctaaagccgg tgtaacataa agtgaaaggg ttgcttctga 520141 agcaccgacg aatgaagtga catatgctag tgcgaagtaa ggaataaccg tcggcaataa 520201 tcctaagtaa acgatagaca aagttgcgct tattgaagcg ttcatcatct cttcgcctaa 520261 gcctggcaga aacacaagca taggtattgt tccgccccaa atggtgaatg taacgaatgg 520321 aataaaacca tattttttta tatagcgggc ttgaaaaacg aaataaatac tctccgaaaa 520381 tgctgccagc aggatgacca agataccgct cattgaatat gtaaagtctc ccgccccaaa 520441 tgcaatcaat aatacaccca ataaactgat catagagcca agccatttcg taaatccaaa 520501 atgctcttta taaaacaggc gggatagcat ggctgagaag atcggtgccg tagtaacgag 520561 taagcttgca actccggcac taactgtttt ttcaccgatg ttcagcaaaa tgtgatagaa 520621 tgcaaatcct aaaaacccta aaagaaaaat ggcaggaatg tctttcaagt cgggtaggcg 520681 catctgagtc aaaacagcaa aaagcaataa tgccatagag ccgattaaca aacgaaataa 520741 agcaaggtgt tctggcgtgt acccttcaag tcctgcgcga attcccggaa aagcagatgc 520801 ccataaacca atcatgagac tatgagatat cattatttga actgttttct ttcgcattcc 520861 tctcactcct ctttacaaaa accaaccagt tatttaatgt gtttctatac taataaagat 520921 ttgatgatat ggcttcaacc agttcaatag attttgaccc aaccaattta ttttaaggag 520981 accgattcta tgagctttcc agaagaaaaa aagatgaaaa agctccctaa gtacagacaa 521041 atcgttcatt ttattaaaga gaaaatagga aatggagagt ggccgattgg aagcaagatt 521101 ccaagccagc gcacgcttgc aaaagatttt caggtaaatc ggagcacagt gattacagcg 521161 ttagaggaat tgatggccga tgggctaata gaaggcacaa tggggaaagg cacagttgtt 521221 atcaacaaca catggacact gatggctaag aattctgctc ccgattggga tcaatatgtc 521281 acctctggca ttcagatgcc aagccgaaaa atcgttcaag agataaatca atcagaatca 521341 aatacagacc ttatacagct cagtaaaggt gaactttcag ctgagatttt tcctttggct 521401 gttatgaaag agatgatggg gaaggtatct caacacatgg aggcattcgg atatgaagaa 521461 ccaaaaggtt acttaccttt gagggaggca ttaagcaact atttaaaaac cattggaatc 521521 aacgtctcat cttcttccat tctgattgtc tcaggagcgt tgcaagcctt gcagctgata 521581 tcaatggggc tgttacaaag aggatcaacc gtttatcttg atcagccctc ctacctttat 521641 tcattacacg tatttcaatc agctggtatg aagctgactg gacttcctat ggataatgaa 521701 ggacttttgc ctgaaaatgt tcatttaaca agaggagagc ggggaagggc tatcttatat 521761 acaaatccat gttttcacaa tccgactggt attcttatgt ctaaaaagcg acgggaagaa 521821 atcctagcag taagtgagaa tacacagctt cctattattg aagatgacat ttatcgtgag 521881 ttatggatcg atgaaattcc gccatatcct attaaaacaa ttgataaaaa tggacacgta 521941 ctgtacatag gaagtttatc gaaaacatta agcccaggtt tgaggattgg atggatcgtc 522001 ggaccggaac cggtgattga acgtttatct gacattaaaa tgcaaacaga ttacggatcc 522061 agttcgctat cccagagagt agcggcagag tggtttactt ccggccacta ccagcagcat 522121 gtagaaaagg ttaggcagca attaaaggtg agaagagaat tggccttgag tgctttagaa 522181 actcatttga aagaagtggc gacatggaat atcccaaaag gagggttttt tgtctggata 522241 aaaatattgc cttccatatc aatgaaatta ctttatacta aagccttatc aaaagggatt 522301 ctgatcaatc tcggcagtat ctatgctcag gaaaaaggga attatattcg cttatcatat 522361 gcttatgcat ctcttgaaga ccttcaaaag gggatttatg agttgggttt aatgattaaa 522421 gaattggcaa gcaggtaact tttatatcct taaatggatg tttcactaaa aaagagatca 522481 agcctaatga tcgcttgatc tgataataac aagggttact agaatagacc aaatcatggt 522541 tcggtcttaa aataatcatg tctctgaacg aaaagtcttt ccgacttctc ttcctaaacc 522601 aaagtagtgt ctgaaattat agataagcgg gctccatttg gaagggttga tatggttttc 522661 gtccagaatg atactttcct cggcatgaaa atgtagtgcc tgcgtctcta caattgcgaa 522721 tgacgattca tattctggaa gccgaatgtg tttcacttcg gcttcgattt ggatagggca 522781 ttctttaatt cgtgttggtg atactgtttt tgattgtaaa ggcgttaacc ctgctgcctc 522841 gtatttttct tttttatatg taaatccgat ctgcttcttt aaaggcggta tactcttttt 522901 tccgctataa gatgaaattc tttcaacgtt ttcccataaa tccgggccag gcaagtttat 522961 gacacactct ttgtgtcttt ccaaattgtc gatggctttt cctcccagtc ctactccaag 523021 gattatataa tgtccaagag cccaagaaga agacatagga ctaatattag tggttccatc 523081 ctcattcaat gtggttagaa gaaatgtcga ggtaccataa tacatgatct tgggtttgat 523141 ttccttaaat cgacgagtgt cttgtttttt gatgtccaac gttttttcct ccttgtcacg 523201 cttacattta tattgtaaag gattaacatt tcaactatca tcgaaatatg aatgtaagga 523261 ggaaaatcat gaatcctaat attgcaaaaa tctcttcgtt gctatcagat ccctcgcgtt 523321 cttccattct tctcagtctg atggatggaa ggatacaccc tgcgggagag cttgcatatc 523381 tcgctaacat taaacctcaa actgcaagtt ttcacctgaa taaattgctt gaagcaaagc 523441 tgattagcgt agagaagcat gggagacatc ggtattacag attggctgac tcagatgctg 523501 caaatgtgat cgaacaattg cttcatattg cgcctaaagc aaaagtcaaa tctttaaaag 523561 agtcaaaaga gaaaaaggac ttgcatttcg cccggacctg ttatgatcat ttggcaggtt 523621 atgtgggcgt gcaaatggca cattcactag ttgagcaggg gatgttaaaa aaagttgatt 523681 taaactttga ggtgacttca gagggtgctt tattcttttc gaagttaggc atcaatgaag 523741 agcaacaacg gaataagagg agagcctttg cccgctgctg tttggattgg agtgaacggc 523801 agcatcatat tgcaggagca ttaggaaacg ccctattggt gcgcatgtta gaagaagaat 523861 ggatcgttcg tatgcctaaa acgagagcga ttaggattac acaaagcggg aaaatcgcgt 523921 ttgaaaagca cctaaacgtg aagatttagg attttgaagc ggaaacatca gatgatgagg 523981 cacgatatct aggaggagta agatttgttc taatcttact ccttcttctt attttgaagc 524041 agctcgattc cccattgcaa tagagatgcg gttccaactg tttatttgat taatgatcag 524101 aacaaggtca acatattgtt cctcatcata atgttcccgc acccgatgat atagctcatc 524161 aggaaccctt ttagatggaa tgagcgtgat gtgttcagat agttcgagag ccgctttctc 524221 ttcaggtgag taaaaatcac attcattcca agcatgtaaa cagtaaattc gctgttcagt 524281 ttctcccatt ttgcgggcat cggacgtatg catatctatg cagaaggcac agccgttcat 524341 ttgagagact ctgattttga ttagttctct cgtcgttcgg ttaattgagg attgtttcgt 524401 gtatttctcc atatccatca tgattttcat accttcaggt gcaatctcat agtaggacac 524461 tctttgactc ataaagcaag actcctttcc atagaatacc tagattgtat cccggtattg 524521 atcattttac caatgtgcgg tttgaatgac agctgtttca gcgtcttttg gaaagaagct 524581 tctttgaata aaaataaggg tagccagcaa tgatgagtgg agctgctaat gcaagcagta 524641 tccatgagcc tgattggctg tctctagtga ctctaatgaa tatataagta ccgatcagaa 524701 aatataataa agcacctaga aaccaataca tgttcattcc tctttttcct tgctttttgg 524761 ttgcgcattt ttgtctgtca tatggcttaa tcgatcaggg ttctgatttt ttaatacctt 524821 ttcggtccgg attccttttc tctttaatga taaaattgtg agatcaatcg atttcaatga 524881 tgatcattcc ttcaatgaat agtaagttcc ttatgatttt aaaggtaaat ttgaaaagat 524941 aaaacgtaca tagaggcaga acgttcatgt acgtttgggc aatgatcact tgttggaaac 525001 tctaatgttt ccctgcacct gatattgttg tgttccttct cttcctataa aatgattgga 525061 tacatgtatg tttgcacgtt gaaatatggg ttcgattttc atgaatctct attcggtgaa 525121 acaggtaaag gaagtggata aggtttgctt ataaggaatc cttttaaaga taaatattac 525181 tcacatgata ggcgggcatt aaacatgctt gcactcagag tgccgggcct ggcttttatt 525241 ctcatgatct atatagcctc tatcgtgctg caatttgttt ctgggggctg gtccatttta 525301 ttgctttatg cgtttaccat attaatcgcc atttttgctt tgcttcattg gcactcatat 525361 cgctgggtta agaaaagagt gattctgtat ttcgcggtac aaggtttgat cacctttgca 525421 cttgctaatc tcatgactgg cttctttata cttgtgatta tcggccttta tgcattttta 525481 attggacaaa ttataggaat ggcagacaga agaaggactt ttctcattct ttatctattg 525541 ctgctgctgg tcataaattc ggcgtatcac cttcataaag gtgaagtttt gcattttatt 525601 gttattgctg cgccgatcat gattgtcatc atcacttatg ccgcaacatt ttttgcccaa 525661 gtcgatgaaa aaataaaagc tcaattgact cttgaaaggc tggagctggc tcatcagcag 525721 gtagaacagc tgacgctgca gaacgaaaga cagcggatgg cccgagactt acacgatacg 525781 cttgctcaag gtcttgtcag tttaaatatg cagctggatg cgattcatgt tcatctcgcc 525841 aaaggcaaca cagagagagc gaaggaaatc atacaacaat cgatgaaaag agtgaaaagc 525901 acaatagctg atgcacgttc agctattgac gatctccgca gcaaatcaga agaaatcggt 525961 gttttaaaag aaagaattac ctcgctaatg gatcatttta tagagtcgac aggcatggct 526021 tgtttattag attacagatt gcatcaggtg ctggatgtgc gtacagctga aaactgttat 526081 tacatcattg gagaatgcat gacgaatgcg gcaaagcatg ctgaggcgaa aacaatctgg 526141 atatccattt gggatgatga aaagggaagg ctccatttaa cagttaagga taacggcaag 526201 ggatttgatg ttgaaaaagg aaagaaaaag agaggacatt atgggcttct tggcatacaa 526261 gaacgcgtca gggcaataaa tggccaattc aatatcaaga gtacaaaatt gaaaggaaca 526321 caaattgaga tcactgtacc aattcaggga gagatgcaag atgaataagg ttttaatcgt 526381 tgatgaccat cttgtcgtga gggaaggtct gaagctttta attgaaacga atgatcaata 526441 caccattata ggagaggcgg aaaatggaaa agtagcagtc cgtcttgcag atgaattaga 526501 accggatatc attctgatgg atttgtatat gccggagatg agcgggttag aggccattaa 526561 acaaataaaa gaaaaacacg atacccccat cattattttg actacatata atgaagatca 526621 cttaatgatc gaagggattg aattaggagc gaaaggatat ctgttaaaag atacgagttc 526681 agaaaccctt tttcacacaa tggatgcagc catcagagga aatgtgctat tgcagcctga 526741 tatccttaaa cgtctgcaag aaatccaatt tgagcggatg aaaaagcagc gcaatgagac 526801 gcagctgaca gaaaaggaag tcattgttct aaaagcaatt gctaaaggtc ttaaaagcaa 526861 agcgattgcc tttgatttgg gcgtctctga gcgaacagta aagtccagat taacgtccat 526921 ttacaataaa ttaggcgcga attcaagaac tgaggcagta acgattgcca tgcaaaaagg 526981 tattctgaca atagacaact aaactgcata tttgaaaatt gcccaaacgt acatgcccga 527041 atgtacgttt ttttcatttc attgtcaact acaatgagaa agaatgtgat caagcaatgt 527101 gttgaaagga gattatcatg tcaaaaatgt tatatacatt aggaggatgg gttgctcgca 527161 atcgcataaa agcaatatgt gcgtggatcg ttgtgttagt tgctgcgata ggccttgcag 527221 tgaccttgaa accaagtttt tctgaggata tgtccatacc tgacacacct tcggaaaaag 527281 cgatggatgt gattcaaaaa gaatttcctc atggtcctga taaagggagc atacgggtta 527341 ttttcggtgc tggtgatggg gagaaactta ctgggaagcc agcaaaaaaa gcaatagaag 527401 atacgttcaa agaaatcagt aaagatgatt ctgttgactc gattgcaagt ccttttgtga 527461 cagggacaat cgcgaaagat ggcacagttg cctatgctga tatccagtat aaatcatcag 527521 cagatgatat aaaggattac tctatcaaac acttaaaaga cagtttgaaa atggctgatg 527581 atgaaggatt gcaaactgag ctaagcggag atgtaccggg agcggagatg gagataggcg 527641 gtgtctctga aattgtcggc attatcttgg cttttgtcgt tttagccatt acattcggtt 527701 ctttattaat agcaggtttg ccgattttaa ctgcactgat tggtttaggt gtaagtattg 527761 gactggtttt gattgggaca caagtatttg atattgcttc tgtcagtctt tcattagccg 527821 gaatgattgg ccttgctgtt ggtattgatt atgctttatt tatttttacg aaacaccgcc 527881 agtttttagg cgaaggcata caaaagaatg aatcaattgc gagagccgtg ggaacagcgg 527941 gaagtgcagt ggtttttgcc ggacttactg ttatcgttgc actttgcgga ttaactgtcg 528001 ttaacattcc ttttatgtct gcgatggggc tgacagcagg gcttagtgta ctgatggctg 528061 ttttggcttc catcacactt gtgcctgcgg tcttatcgat tgcagggaag cggatgattc 528121 cgaaatcaaa caagaaaata gaaaaacaaa gcactgaaac aaatgtctgg ggacgctttg 528181 tcaccaaaaa tcctatcatg ctaagtgtat gcagcattct gattttgatc gtcattagta 528241 tcccatctat gcatttggaa ctgggcttgc ctgatgctgg gatgaaagct aaggataatc 528301 cggatcgccg ggcatatgac ttgcttgccg aaggctttgg agaaggattt aatggccaat 528361 taacaatcgt agcggatgcc acaaatgcta cagaaaataa ggcggaggct ttcgcagatg 528421 cagtgaaaga aataaagggc ttagaccatg tagcaagtgt cactcctgca atgcctaata 528481 aagaagggaa ctttgccatc attacggtcg ttcctgaaac aggtccaaat gatgtcacaa 528541 cgaaagattt ggtacatgat gtacgcagtt tatcagataa aaacggagta gatttgcttg 528601 ttactggatc aactgcagtg aatattgaca tttcagatcg cctgaatgat gcgataccgg 528661 tgtttgctgt acttattgtt ggctttgcgt ttgtattgct gaccatcgtt ttccgttcgc 528721 tgcttgtgcc gcttgttgct gttgcaggtt tcatgttgac gatgacagcc actcttggaa 528781 tctgtgtatt tgtcttgcaa gacgggaatc tcatcgactt tttcaaaata cctgaaaaag 528841 ggccgatact cgcgttcctg ccgattttat cgattgggat tctgttcggg ttagccatgg 528901 attatcaagt attccttgtc agcagaatgc gtgaagaata tgtaaaaaca aacaatccag 528961 tacaagccat tcaggctgga ttaaaacaca gtggtcctgt tgttacagca gccggcttga 529021 tcatgatctt cgtttttgca ggatttatct ttgcaggcga agcttctatt aaagccaatg 529081 ggctggctct ttcctttggt gtactctttg atgcctttat tgtaagaatg acactgattc 529141 caagtgtcat gaagctgatg gggaatgcag cctggtattt gccgaaatgg ttagacaaga 529201 ttattccgaa tgtggatata gaagggcatc aactgacaaa ggaaatacag ccggaaatag 529261 atcatgaaca aaagaaacaa atcagtgtgt aatagaaaaa gcagatcttt tatgatctgc 529321 tcttttgctt atggtagtat ttagaagatg aagtcggcag ttaaaaggag acgcttatgg 529381 cgccatcact cattttcgat atggatggaa ctttgtttca tattggcaga agctgcatca 529441 tactagcagg catcccagga gaagtgacat gattttttga ctttgcattc actacttgat 529501 gccaaggatc ttgagaatcc ttcttgaaaa taaaggattt tacaactgat catataagaa 529561 acctaaagaa acaagcacac aaaaccagct gcgggttttg tccaagaaaa atagagtcca 529621 taagagggac tctatttttt gaagtgcccg gctagaagca tattgcagga ctttatgaat 529681 gcaaatcact atcttataag cccttaccgt gaaatgcctg tttctgcatt gaaaaaacgc 529741 attacacgtt catttacgta agtgggttgt tccatcgata aaacatgtcc ggcattttta 529801 atgacttccg cctcaatatc tggaacgaat gaagaggctc ggtgcagggc tgagtgggga 529861 tcatagatga cttcatgttc accaagtaat aataggatag gaactcttgc tgaacgtaat 529921 tcctcatcgg taaaaacata cggaaatccg tcggcattag gatttggatt tcttgatcca 529981 tcctgccaca ttacccctgc cttaaactgc ttcacaaaaa tcgggtgcag cacattctga 530041 tcattcatca tccaatttaa gaatgtttca actccatttg acgctgtaag gccaagagcg 530101 tatttgtaga aatcgtgatg aaatggcaaa aacgtttctg ccggactcag tatagctgcg 530161 ctttttactc tctcaggcat acgtaaaagg aaattcatcg tatggagacc gccaagcgaa 530221 agtccgatca tgtgggactt ttcgatcccc agattgtcaa acacatcaag aagccaattg 530281 gcgtaatccg ttcttgtacc gcttacattc tcaggaatac tcttgttttt atcacctatg 530341 atatcaactg cataagttct gtatttactg ctccaatcgg cgatgttggg ataccacatc 530401 gtcgagctga ataatgctcc gtggagtaat acaagcggcg gggcatcctc tgggccgctt 530461 gcaatcacat gtgtttgacc aaaacgagta gatatataga atgatttaca acggaccggc 530521 caaagactaa ggctttcatt ataagtttga taatagcgga taccgttgtc acttaattcg 530581 ggaatactag atgaatggtt tgacatacaa atgcccctcc caattttgtt taaatgaatg 530641 tgccgtttcg tgatggggaa tctgattttg atataacaga ctttatttac aatataatac 530701 agttgttatt agacgtcaaa tccaagatga aaaggaaaaa aacgattgaa acagattatt 530761 gaaaatcaat ataacagaat attaacctcc tttgtggagc cgcttcatta aaaccgcaat 530821 ccaaatgcat gaatcacaaa aatcacaaca ggagggatca ggagggaagg cagcagattc 530881 agtgttttga acttcttgat tccaagaatg cttagacctg aactgaggat gagtatgcct 530941 cccacaattg tgatttcatt aataaggtct gtattgattg cgctctccat tacttgtgca 531001 aataaataga tggagccctg ccaggaaaat aatacaagtg cggcagccgc tattccaaaa 531061 ccaaaagttg aagcgagcac aatggaggtg atcccatcta acatcccgtt tgtcagaagg 531121 tatgtataat ctccatgcaa agcggcttca acagggccta atattgacag cgaacctata 531181 caaaataata agaccgcagt tgataagccc tctgctaaat tgcttttaga aaatttgttc 531241 accagcttgt tgaatcgtaa ttctaaattg atgatctggc ctagcaaacc tccaatggct 531301 aaactcacga tgaatagaat ggggtattta ctatcaggca aatgctgtgt aatggcgttg 531361 atccccagtg cgaccgcagc gaatcccatt gcctgcatca aaatatcctg gtattcatct 531421 ttaatgcctt ttttgaatat ccccccgatt atgcttcctg caatgatcat cactgtgtta 531481 aaaatcgttc caaacataag ctttctcctc caaaaatcat tcctgcataa aaaataaacc 531541 ctctagttag tagagagtca agggagatca aaacatattc atgagattat ttgatgggca 531601 gcaggatttc agtcacgtaa ttatctaggt tattcgtaat gccataatca atgagtgtga 531661 tttcgattga gtcccctgct acctcataat gatgttcttt catatatgcc agtaattttt 531721 tgtagtatgg ttcggcttct ggatgtgacc ctttaaacct aatttgcaga tattctcttg 531781 aaggaaagat gatttctgaa gaagtttttt cattttcatc ttcaagaatc ataaatatac 531841 tggaatattt gtcaaactgt tttgctttca catttgctgc agaaatggat aaaccaatct 531901 tgcctatgaa tatatcttcg tttacattca ggtgggttct caattcagct aacgaatgtt 531961 cgatatcatg gccgagaaca tattcatgct gcaaataggc cacacgcatt gcgggaagtt 532021 tgatttttga aatttgatgt aacggcatgt taacggcatc ttctatatgt gtgatgcgtc 532081 gggagatctt tcgttcaatg cgttccaatt ctttcttctt gcgatcaatt tcaacctgct 532141 ggctttttag taaatgaaga agagtgtttg tattttgaga gttataaaaa tcaagaagct 532201 tattgattgg caggcctagg gccctcaaat acttgatggt atccagccgc tcaaactgtt 532261 gggtagaata atatctatag ttcgtttgct catctttata ttccggtttc aaaaggccga 532321 tttcatcata ataccgaaga gcagagattt tcacattgaa taactttgac acttctccaa 532381 tcgaaaaaaa ttccttcatt ctaacaacct ttctgtccta tgattgatat acacacatta 532441 tatagtacgg cgagtactaa aggtaaagtt tgcagcataa agaaaaaact ccttctaaaa 532501 aggagctttt cattcttcga aataaggatt tacatggatg agcacttctt ctacatctga 532561 aaactgtctt ttgatttcat ttcgaatttc gcgggcaatg tcgtgtccct gcttaattgt 532621 caaatcatga tccaaagata aacggacatc aagcaattta tagtggccat gttctcgcgc 532681 gcggattcta tcaattcgtt ttacctgatc acattgaaaa ataacagctt tatattcctc 532741 tatcagctcg ggatcaacac tcttttccat gagcacatca acagacggcc tgattaattc 532801 cattgaaatc ttaaaaatga ggtaagcaac gattgcactg gcaatggcat cggcgtacaa 532861 cagataggac catccacggc tgtttccgat gatagccaac aggacgccga taaaagcggc 532921 aagagaggca acgatatcgc ctttatgatc gtacgcaatc gctataatcg ctttgctgtt 532981 ccattttttc ccttgcttta tagaataacg atataagatt tccttagcca cgtacgaaat 533041 cagagccgca aacaatgcgc tgtattgggg aacgcttggc cctttaacaa aggacagaat 533101 cgcttctatg aggatataaa cggatacgat cactaagata attcctacaa tcgcctcact 533161 aatgacttca gcttttccgt gaccaaaagg atggtcttga tcgggcggtt tattggaaat 533221 tccgatcact gccaagactg caatcgaagc aacgacatct gccgcggaat gtattccgtc 533281 tgcaaacacg gcttcactat cgcctaccag cccaaaaaag acctttcctg ccattaagat 533341 cagattggcg atcaatgcaa tcaaagcaac ttttctgctt atttgttctc tttcacttgc 533401 cattttttcc tcctataaaa ctgcacaaaa aaataggagt gctctatata cgctctccgt 533461 atcctttcct gtgtaatcac tttgtttatc ataccaattc aatttcgagt gggtctatag 533521 caacgttgtt tcctgtttac taataaataa ggtgacagaa aaaaagttgg agctatgcta 533581 aaaaggtcat acagcaaaca aatgagttct tatgtaacaa cagtgatgat tcgctattaa 533641 aatgctgccg tcagtgaaaa atttccacct aattttcaaa aacctattga catgagaaga 533701 tctgtatttt actattatct catattcaag atattttaat ttgagatatt tggtcggaaa 533761 gatcagcgat caagcgcaac tctaagtgtt caatcgttgt cagttctttt acacaatatt 533821 caatatgatt ttttataaca taatatctcg aattcgagat aaaagggagt gtagcgtaat 533881 ggctgaattt actcatttag tcaatgaaag acgatctgca agcaattttc tttcaggtca 533941 tccaatcaca aaagaagatc tcaatgagat gtttgaattg gttgcattgg caccatcggc 534001 ttttaatttg cagcatacaa aatatgtgac ggttcttgac caggacgtaa aggaaaagct 534061 gaagcaggcc gcaaacggac aatataaagt ggttagctct tctgcggttc tcttggtatt 534121 aggggataag caggcatatc aacaagcggc cgatatctat gaaggtttaa aggtattggg 534181 gatattaaat aagcaagagt atgaccacat ggtgcaagac accgtttcgt tttatgaaaa 534241 caggggagaa caatttaaga gagatgaggc gataaggaat gcttcacttt ctgcgatgat 534301 gtttatgctg agtgctaagg aaaaaggctg ggatacctgc ccgatgatcg gctttgatgc 534361 ggaagccgta aaacggattt tgaacataga cgaccaattt gaggttgtca tgatgattac 534421 gattggaaaa gaaaaaacag agagcagaag accgcgcggc taccggaagc ctgtgaatga 534481 gtttgttgag tatatgtaaa aggagcggat aaaaatggct aaaaaaacga tgggaattca 534541 tcatattaca gcgattgtcg gtcaccctca agagaacaca gatttttacg caggagtgct 534601 tgggcttcgt ttggtcaagc aaactgtcaa ttttgatgac ccaggtacgt atcatcttta 534661 ttttgggaat gaaggcggga agccgggaac aatcattacc ttctttccgt gggccggagc 534721 ccgccaaggc gtcattggag acggtcaagt tggcgtgact tcgtatgtcg tgccgaaagg 534781 ggctatggca ttttgggaaa agagactaga aaagttcaac gttccctaca ccaaaatcga 534841 gcgctttggg gaacaatatg tagaatttga tgatcctcat ggactgcact tagaaatcgt 534901 ggaaagagaa gaaggagagg ctaatacgtg gactttcgga gaagtaacgc ccgatgttgc 534961 cattaaaggt tttgggggtg caaccctatt atcagagcag cctgacaaaa ccgctgacct 535021 tttagaaaac atcatggggc tggagcgagt cggcaaagaa ggagacttcg ttcgttatcg 535081 ttccgccggt gatatcggaa atgtgattga ccttaagtta acgcctattg gccgcgggca 535141 aatgggggcc ggaacggtgc atcacatcgc ttggcgggct aacgatgatg aagatcagtt 535201 agattggcaa agatatattg cttcccacgg atatggtgta actcctgttc gggatagaaa 535261 ctactttaat gccatttact tcagggaaca cggggaaatc ctgtttgaaa tcgcaactga 535321 tcccccaggc tttgcacatg atgaaacaca ggaaacaatg ggcgaaaaac tgatgctgcc 535381 tgtgcaatat gaaccgcatc gcacacaaat tgaacaaggg ctgctgccgt ttgaagtaag 535441 agagttagat tgatttgaca cataaaaaat aaagaaacat atattcaatt gatgattgct 535501 ggatggtact gtcagcaaag aatcagataa aatcaaagat gaggagagat acaaatggaa 535561 gatgcaggac tgttgcttat tcgtataatg attggtgtgg tgtttttgtt ttatggcaca 535621 caaaaattat tcggctggtt tggcggatac gggattaaag gaaccggaca atggttcgaa 535681 tcaattgggg tgaaaccagg aaacgttgcg gccgctctat caggtcttgg ggagttagta 535741 agcggaattc tatttatttt aggcgtattc ctcccgcttg gagctgctat cataacaatc 535801 atcatgttag gtgctatcgt aaaagtccat ggagcgaaag gttttgcgaa tggcgccgga 535861 ggttttgaat ataacctggt gctcattgca gtttccatag gggttgcact catcggttca 535921 ggagcttacg ctttgcattt ttaatacgaa agtatgtaag aacagttgct gcttgtcagt 535981 aactgttctt ttattttcac attttcggca agcttgcagg tactctgcaa agcaaaaaag 536041 cggatatcat aaatataaat ctgtatagtg aatgatacgt attgatgagc ttggtcatga 536101 aaaacagacc tatttgaagg agtaaatgga tgaaagagat gacaggatta cattcattag 536161 tttctataga aaactttatc aaacagcaca aattcagttt tatttatata tcaaggcctg 536221 gctgtacagt atgtcacgca gttctgcccc agctcagaat agtattggat cagtttccaa 536281 acatcaaatt ggggcatatc aatgctgacg atgtagcaga ggtcgccggc agattttcag 536341 ttttcaccgt tcctgtgctt cttttgttca ttgatgggac tgagtttcta agagaagccc 536401 gttttgttca ttttgaacag cttgaacaaa agctgaaaag ggtttatcga ttatatgaag 536461 gcgaataaag gaataaggca aaaaaagaac tcaaatgagt tcttttttta ttcttcacta 536521 ggcgaagaag ggttatcaac ctgcccttga tcacttgtat cattatcaca acttgctgaa 536581 ataataattg aatgagaagg agagtaatct cctaatgtga aattcactcc gtaatttttg 536641 ctgttcgcag tatggctgtt ttgcaagttt tgtccgatat ctgtattggc gttttgtgtc 536701 attccattta tcgtgagatt tgagatgttg atttgagatc gcatgcttca aaaactcctt 536761 tcactcagaa gtagctgtca taaaggacgc tggcagtcta tttacttcta tgatattgcg 536821 tttttatatc attgcatcaa cataatggta aaaataatag cgagtgaatg atcatctttt 536881 gaagatgatc aacctatcag cagaaataaa gccgcctgat aaagaggcgg cagatcgtta 536941 tatgtcatct atgaatttga tgtatcgttt ttcgtttgcc tgaaggataa gatagtcgtt 537001 tttaatgatg agtaggagcc tatagcagcg tagccataaa accagcccat aaatacgcca 537061 gaaaagaggc tgtgtcgatg gcttatgaaa acagaaatga caaggcctgt tattaaggca 537121 actgacggta caaaagtttt ggggattttc aataatattt tgaggatttg ggttatcaat 537181 atgatgattg gaacagctat cacagcatcc caaaagttcg tgtgaataat tggaaaagcc 537241 atacggcacc tcatgaagtg tttatttctt aatttttacg ctaaaagctt ggaaagcagc 537301 tcttggatcg catatgttac attttgggct tgattggcgg agcttgtttg gcttaaagca 537361 ttggattcaa aaaccaaacc tgtattactc ccaccggaac cctctgttgt tttagacaca 537421 gagaacgggc tgatggaaac tgcaaatccg ttattaaaaa cgctgttccc ggatatcgaa 537481 tgaatataaa ctgggaattt catcattcat ctctcctctc tgttatgact gtttatacaa 537541 tatggtgtgt gagcagcagt tgcttaaaca aaacggcaaa aactttcagt aagagacaaa 537601 aacctgcaaa atgccacaag cgccttttgt taatgcagct ttttagggac gtttttttta 537661 ttttttttgc caacttcatc aaaaatattc tgattgccag actgggcttg tccgtcctta 537721 tttatgaaat cggggtgaat gagttttttc agatccctga ctgttaaagg cttggcgtca 537781 tcagttaatt ctattcctaa ttgcccgttt gcctctaatg tcgcaatttt gacatcttgt 537841 atagccgtaa cgccgtgaag ccttagctgc atttcaagct ggtcagctgt aagtctcatc 537901 ttctttaagt tttcgatatg aagctgtccg ttttcaatga cgatttttgc ttttccggtt 537961 aacatctttt caatggtgtt cgatttcatt tggatccatt ccataacgat gagtgtgctt 538021 gtgaaaattg ccgctgcaat taatgttttg aagaggctgt actcgatgat tggctgaacg 538081 ataatagttc cgatcgaaat catgacaacc gtttgagtcg acgtcatttg tgcgattgat 538141 ttccttcctg aaattctcag caaaatgacc ccggctacaa tgagaacaag agattcccaa 538201 gtgaaattca tgctaccacc tgaccaatga tgaattagat ttgtcatggg attggctttt 538261 cttccggcca atcgcaattt aatatatccg aaaggcagtc ggttcattct gtcctgaacc 538321 gaacaatatt tttggtatag atggatatat taagccaaac aatgatagca acaggagttt 538381 tttggccgaa acaatctggg aagcggggag cgccataaca tgattgaact tgaagttgtc 538441 attagaacgg ttgccagctt tggcttgctg ttaatcgcag aacgaatttt aggcaaacag 538501 acaatctctc aaatgacgat ttttgatttt attgcggcga tcacactagg ggcgattgct 538561 gccggattag cttacaatac ttcaataaaa ccgcacaata tggccatttc gtttagtatt 538621 tttgtgctaa ccatttttct aatttcgttt ctgtcgataa agaacaggaa gctgaggaaa 538681 ttttttgccg gagatccaac agtgctgatt caaaacggga agatacttga atcaaatatg 538741 aggaaaatgc gttacacact tgattattta aatcagcaat tacgggaaaa agaaatattt 538801 aatatcgaag aagttctttt tgccattctt gaaacgaatg gtcagctgac tgtgttaaga 538861 aaaccgcaat tccggcatgt gaccaaacag gatttaatga ttgcggtaaa ccaagaacaa 538921 aggcttccga tagaacttat tatggacgga gaaatcattg agaataattt aaagcagaat 538981 cgtttgacgg aatcctggct tttggaagaa ttgcgaaaaa gagacataaa ggtgaaagag 539041 accgtgtacg cagtgctgct gggtaatggg gatatttatg tggatcaata taaagaccat 539101 atatcagtcc ctatggataa ggaatgaagg aacaatcaat cttaaagccc cttattgaac 539161 gcaacggttt caacttgtct tgggtacgaa atatgcagaa gcccgtttaa cagctgaatc 539221 tgtaacaaat gagtttcagc ggcttcggga agctgaatga ttcgctcaat ttctccgtaa 539281 taccgttcac gcagcacttc catttcggct ggaaaaacag gcgtgatcgt tcctttgatc 539341 agcagctggg ttttagacag taaacggatc gttaattctt cctcatacac accgggcatt 539401 tccacaatga taaaattata ttcctcatct tgataaaagt cgtaaacaaa cgtagaagct 539461 tcggaatcaa aaaaatgttc cggggcttta tatttgagca catttgtcca aaagtcactt 539521 tgtttatatt cattcgtaat ctcaagccac tttcgaattt tttcgaaatc catatgagat 539581 tctccttaaa tttgatttga aatcggcgca gaagggtttc cgatttggtc ttggtcacta 539641 acgtctgaat caatatttcc agtgtttaaa agtgaagacg taggcgaaag atcccctaag 539701 gaaaagtttg ctccaaaata tttgctgttc gcagtatggc tgttgtgcac agtcggaccg 539761 acatctatat ttccgttttg cgtgacgccg ttgatcttaa tatttgcgat attaatttga 539821 tatggcatag acgaaacccc tttaatctaa aattggcggt ggtgcaatcg gaggagcatt 539881 aacgttggat gtatcagagt tgccgataga tgtctggtca tttacatcag gatcgtttaa 539941 gaagttttcc attacggatt ctgtaggtga tgtatcaccg aaagaagagt tggtcccttg 540001 agatttttga ttgttggtag ggctgttata agcagcttcg cctattgtaa ttgaaccatt 540061 gcccgaaata ctgttgatct tcaaataata taggttgatt actgtagacg gcatcccatc 540121 acacccttcc atctttctgt acagtacatt atgcgccgct gcacccaatt gttccttgca 540181 tttacgggca aaactctatc tggccccgga gtgatgctca attatcagtg aatgaaaagc 540241 cattgatata ggaatcaatg aattgattca gttattcgaa atgcatgaga ccttttaata 540301 aaggaagctg gcaaacagga tcagtttgaa ataattgaca atgaagctaa tgccatgaaa 540361 taatactcgt gagtaacatt actcgtgggt attatttttg gggtggtcct agttgaaaag 540421 taaaggagta gaaagccgaa aacgattact taaagctgcc gctaatgaat tttcggttcg 540481 gggattccat gacgcgaagg taagtgaaat tgtgaaaaaa gctgggttca cgcagccttc 540541 attttacctg tactttcaaa gcaaagaagc catctttgcc gagttaataa ccgattttca 540601 ctctcgagtc agaaagctga cagagtcact tcttctggaa aacggattaa acacggagga 540661 tgtgtcaaaa cgggtactgc tagctgtaga gactgttttt caatttttgg atgaggacaa 540721 ggatttaacc aagatcggct tttttctcaa cccggaagca aaacaaatga aaaaagactt 540781 ggcgatggtt ttgaaagaga acttagaagc agaacagcgg cttggctatt ttcactctga 540841 actggatatg gaaactgtcg ctgagtgttt ggtcggcatg attgaacatt taaccgaatc 540901 atttttgtta accggaatca aagatccggc aagcctcgca gcagaggttg tgaatctttt 540961 aatttacggg atgcttccga aagggaatga tgtaagatga tatctattat gatgaaagtc 541021 agtttggcag tttttatgct tgcgggaggc atcataaagg taagccgcgt tccctttcaa 541081 gttgagcatt ggcggcatta tcaatatcca ttatggtttc tgactgttac tggcattctt 541141 gaaatagccg gggcacttgc tatgacagcg ggaatttgga atcggtatgc agcaattgga 541201 gcaggtgttc tgtttgtcgt tctcatggcg ggagcaattc atgcgcatat gtttcgagca 541261 agacaatctg tcatcatggc gatacaagcg atgatttgtt tgattgtttc aatcatgatc 541321 atcatgggga gttacacgta agcttttcac taatgtttaa gaacaagccc atttgcagga 541381 aatctccttt tcttatcgaa taatagaaag tccaggaatt aactgaatca gtaaaataga 541441 gctccatttc tgtgttattc gtccggcatc agctgggctt tttttataaa ggaggaatac 541501 aggatggcat tcactttgga agacatgact gaggaagagt tcgaagcctt tcgcgggatg 541561 tccgtgcaaa attttgcgaa acaaaacata acgtcaggaa cttggacgga aaaagaggca 541621 tttgagaaat cggagcaggc atatgagaac atgattccga atgggcgaga cagcagcaat 541681 cattattttt ggaacatcac aaatgaccaa ggagaaagaa tgggctggct ctggctgtat 541741 gctgatccat tacatccgca aaaggaagcg tttatctatt cctttggatt gtatgaagcc 541801 tttcgcggaa aaggacttgc tcaattggcg cttcaaacgc ttgatgaaag agcaagagag 541861 cttggtgcgg aaaggctggc tctacatgta tttgcacaca acgagacagc cgtctatctt 541921 tatcagaaga tgggctatgc catgaccaat atacgtatgc ggaaacagct atgctgaaaa 541981 gccgcttacg ttacccaaat acaacatgcc tatctggaag cggtggcagg gtactataag 542041 tcatcattag aaagattaag gtcatgggag gcttgaacat ataaagaaaa aggacaacag 542101 ctgttgtcct tttcaatgcc gcttgaactt tctccctcag tcttttttgt cttgatgatc 542161 cagctctttt attcgtttcg taagctcatt gaaagcctga tcaagctcct tatacccttt 542221 atcatttggc gtcataaaac tgagctttcc cagcacttct tgtctttctg tctcaagctt 542281 taaccgaagc tcctcccgct catttctttc tgaaggaacg tcgtttaact gcttttcgat 542341 gccgttgttt gagatgacga gtttactgtt tgttgttttt tcgagaaagt atcggtcatg 542401 tgaaaccgcc agcaatgtgc cgctgtattg tgacagtgtt tcttccagct gttcgcgtga 542461 cggcaggtcg agatggtttg tcggctcatc taaaatcagc acgtcttttt cctccagaat 542521 atatgccatc agcttgatct ttacacgctc acccatactc atatgcttga tcggttcagt 542581 ccattgggcg gctgtaaaac ctaagtgcct catcagattt tgaacgtgcc cccttgcttt 542641 gaatgtttca ttctcaaata actcttccgg tgtttgttct aaaggcaaat caaacacctc 542701 ctgcgttaaa tagccgatgt ttgcggacgg cgacacccat acacttcctt ctgctgtttc 542761 ctgtcccaga atgatgttca gtaatgtcgt ttttccgctg ccattggggc ctatgatcgc 542821 aaccttttcg ccgtgctgaa ttgtaaagtt tgcgttttta aagagagtcc tttctccaaa 542881 cgcttttgtt acattctgaa cttctaaaaa acgttttcct gttttgtggg ttgtatcgat 542941 tgaaaagcgg actgtatatt ctggggtaac gggttccgcc tttgcttttt caagctcttt 543001 ttcaagccgc ttctgcttgg attttatctg ggcatccgta cgcttcgctt ttacccggtg 543061 atattcttta aacccttcct ttttcgtcga ttgagcatgg gctttttccg accaagaagc 543121 gagcccattc atttgtgctt caatccgttc aaccattttt tgctgctttt catattcacg 543181 ctgctgggtg agtcttttct tctcccggaa cttcatatac ccggagtaat tccctttgaa 543241 ttcaatcagc gtctgatcct caagcgacca tatttttgtt gcggcttcgt ctaaaaaata 543301 tcgatcgtga gaaacgagaa tcacagtgcc gttataatgt ttcagctgtt ggatgagaaa 543361 ttgcaagctt ttttcatcaa ggtggtttgt cggttcatct aacagcagca gatctgcatc 543421 ctctgatagt cctttcgcca gccgcgcttt cagtttttca ccgccgctta actgatgaaa 543481 atcacgaaga ggcacatgcc atttctccag taacttcttt tcggcaggtg tctgatccgc 543541 aaaggaatac gccgcggttt cctgttcaac caaagccagt tttatatcct tccgaaggat 543601 ttgaccctgt gcaggggcta agtcattgtg aatgaggtgc agcaacgtag atttcccagc 543661 gccgtttttg ccgataatcc caatgatatc tccttgctga acactggcgt ttacatgttt 543721 aaaaacagtt tgatccttta cttcatagct aacgtttgtt aatgttacga tctctttcat 543781 ccatatccct cgctttaaag ggagaataaa aaaatcctcc caaatgtgtt ggaaggatta 543841 gccgtgcctg tgcatgatca aataagctat tttttataaa tagcagtgtc gtatatatag 543901 aaaatgggca gactaatcct attttttgat ttgaaatatt gatttcaaac ggtaaaaata 543961 agattagtta atcattgtcc acccatcatc ccttcttgtt ttgattacaa acactatagc 544021 atacctttaa attcaaaagc aaaggtcatt ttcatcaaaa aaactcctgc tctcattttt 544081 gaggcaggag ttttgagtct tattgatgct tcgcttttct cactttataa atcacaatca 544141 gcaaaataaa ccaaaccggt gtgacaaata aggaaacacg agtatcctgt gccagtgcca 544201 gcacaaccag aacaaacgcc aggaacgcaa gaatcaggta atttgtaaac ggataaagcg 544261 gaagcttaaa cttgtttgtt ttcgctaatt caggtcttgt tttgcggtat ttcatatggc 544321 agatgaccgt aatcccccaa atgtagataa agcatacggt tgaaatactt gtgatcaggg 544381 tgaatacgcc ttctggcatg atgtagttta acgtaacacc gattaaaatc acgatagctg 544441 aaaagaataa agcatttcta ggcactttac gctgagtcag tttcgccatt gactcaggcg 544501 cattgtgatc tttcgccagg gaatagacca tacggcttgt actgaataca gcgctgttgc 544561 atgctgaagc agcggatgtc aacacaacaa agttgataat acttgcagcc ccgacgatgc 544621 caacagcgac aaatacttgt acgaatgggc tttcgctggg attgatgata tcccaaggat 544681 agatgctcat aatcacgaga agagccccga tataaaaaag cagcacacgg acaggaatat 544741 tgttgatcgc cttagggatt actttttcag ggttttctgt ttcaccggcc gtaagcccga 544801 caagctcaat gccgacaaaa gcaaacacaa ccatctggaa cgagaggata aacccgtgca 544861 tgccattcgg gaacaggcct ccgtggctcc agaggtttgt gaagctggac actcctgagc 544921 ttgtggaaaa gcctttgaaa atcatcacaa ggccaatgac gattaacgcc aaaatggcaa 544981 tgactttaat caaagcgaac caaaattcta attctccaaa aagcttgact gtcgccagat 545041 tcataatcag taaaataata agagcgatta agccaggcac ccattgcggc acacccggga 545101 gccaatattg agtgtagagc ccgactgctg tcagatcagc catcgcaatg gaaatccagc 545161 agaaccaata tgtccagccg gtgataaaag ctgccatatc gcctaggtag tcttgtacaa 545221 aatccacaaa agagtgatag ttcaagtttg ataacagcag ttcacccagc gatctcataa 545281 ttaaaaagca aatgatccct gtgatcatat aagcaaataa aatcgaaggt ccggcaaaat 545341 gaatcgattt gcccgagccg agaaataagc ctgtcccaat ggctccgccg atggcgatga 545401 gctggatatg cctgtttttc aagcctctct gcaacgtttg ctgatttata ttgtctttcg 545461 tcatgtcgtc tgtcacttta tgtgttcctc cattgaaaat tgtttattga gtcagcaatc 545521 tatttttaat gattattata acactaaaat ttctatcttt tttactaaaa aaggattgat 545581 gaaaagaatt ttaatgtgat ttggactatt tcccgaaaaa agcggctcca tttagggagc 545641 cgctttttta tgctttttca gtttttgtca taaacaggta gagcccgtaa tctgtcggtg 545701 cggatgcgta gcctgcctgc cgcagcattg ctgtgatatt gccgcggtgg tatgtcccgt 545761 gattgacaac gtggggaagc agttcggaaa cagttgtttt catgattccg cttgagggat 545821 tttgaatctg gagtggctta ttgagctgtt ctttttgctg taaaaatagt atatagcgct 545881 cggataacct cagaaaaagg tcttccattt cctctatttc tttagcctct gtctgttctt 545941 taagctgttc agctaaagcc aacgcatcgc tcaaggtttt gccggaaaac acttcaatcc 546001 agccgagatc agaaagataa acatgagaca atacatggga tattgacgga aacacgcttt 546061 gaatttcttg atggtatatc tcttttggaa gctcttttaa tcggttgaat atttgttgat 546121 tggcccagac gttatattca tacaatttga atgcaaaatc tgacatgtta aaattccccc 546181 tttcgtgtgt atagctttca ttatacacga acatgagttc ttatgtagag tgctcgaaaa 546241 taaaatttgt tgacatatat agtttagagg aataaactaa ttgacattga acataaagtt 546301 tagcggggta aactataatg cgtctgatta gagctcattt cataaattct tgttttttgc 546361 agcacacctg tcgactcaag aagcaggtta tccagcaggt cagtaattaa gtttccgtgg 546421 ttatacaccc acgacccgtt ccacggattg ccccctgcat caacaggaag ggaactttgc 546481 gctccaataa tataatgatg aggattagca tgtttaaccg cttcatcaag tggcgcttga 546541 tctgtacctt gactgccgac accttcaccg cctgattcat ctaataaagc attgattgtg 546601 ttttgaacca gttcaacgtg ggcaatctcc tctaaaaaaa tgccgcgaag cagatcgcgg 546661 tactgtttct gctttcctct gaaattagag ctttggaaaa aaactgcatc attgtacgca 546721 tttctccgta atgaccgcct aatatctcct gcaggacctt agcagctgcc gggtctggct 546781 tgtccggttt aatgatatta atcagttcct ctttgtagta atacataaca cgcctcattt 546841 cttcttaaga gattttctta tattatttgt aagatgagat aaaatatata catgataagc 546901 atgggaaggc gtgaaagaag aaaataaaaa aatacaggaa aagtgttgac caaataaaac 546961 aggcatggta tattattaaa cgtcgctgat gaacagcgtg aaacaaaaca gaaaaacaaa 547021 aaagttttcc taaggtgttt acaagatttt aaaaatgtgt ataataagaa aagtcgaatt 547081 gaaaaagatt cgaaaaaaca ttaaaaaact tcttgacttc aacatcaaat gatagtatga 547141 tagttaagtc gctcaataag cgcccgtagc tcaattggat agagcgtttg actacggatc 547201 aaaaggttag gggttcgact cctctcgggc gcgccatata agataccacg cgggtgtagt 547261 ttagtggtaa aacctcagcc ttccaagctg atgtcgtgag ttcgattctc atcacccgct 547321 ccattattga atgatctttg aaaactaaac aagacaaaac gtacctgtta attcagtttt 547381 tgaaaatcgc acagcgatgt gcgtagtcag tcaaactagg gcctgcacga tgcaggtcac 547441 acaggtgtca ccgcgggatg cggtggactt aacctgtgat ccatttatcg gagagtttga 547501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cgaacagatg 547561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 547621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 547681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 547741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 547801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 547861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 547921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 547981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 548041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 548101 gcccccggct caaccgggga gggtcattgg aaactgggaa acttgagtgc agaagaggag 548161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 548221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 548281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 548341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 548401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 548461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 548521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 548581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 548641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 548701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 548761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 548821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 548881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 548941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 549001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 549061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 549121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaattag taatacaaga 549181 tatcacatag tgattctttt taacggttaa gttagaaagg gcgcacggtg gatgccttgg 549241 cactaggagc cgatgaagga cgggacgaac accgatatgc ttcggggagc tgtaagcaag 549301 ctttgatccg gagatttccg aatggggaaa cccaccactc gtaatggagt ggtatccata 549361 tctgaattca taggatatga gaaggcagac ccggggaact gaaacatcta agtacccgga 549421 ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc gaaacgggat tagcccaaac 549481 caagaggctt gcctcttggg gttgtaggac actctgtacg gagttacaaa ggaacgaggt 549541 agatgaagag gtctggaaag gcccgccata ggaggtaaca gccctgtagt caaaacttcg 549601 ttctctcctg agtggatcct gagtacggcg gaacacgtga aattccgtcg gaatccggga 549661 ggaccatctc ccaaggctaa atactcccta gtgaccgata gtgaaccagt accgtgaggg 549721 aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc tgaaaccgtg tgcctacaag 549781 tagtcagagc ccgttaacgg gtgatggcgt gccttttgta gaatgaaccg gcgagttacg 549841 atcccgtgca aggttaagca gaagatgcgg agccgcagcg aaagcgagtc tgaatagggc 549901 gcatgagtac gtggtcgtag acccgaaacc aggtgatcta cccatgtcca gggtgaagtt 549961 caggtaacac tgaatggagg cccgaaccca cgcacgttga aaagtgcggg gatgaggtgt 550021 gggtaggggt gaaatgccaa tcgaacctgg agatagctgg ttctctccga aatagcttta 550081 gggctagcct caaggtaaga gtcttggagg tagagcactg attggactag gggcccctac 550141 cgggttaccg aattcagtca aactccgaat gccaatgact tatccttggg agtcagactg 550201 cgagtgataa gatccgtagt cgaaagggaa acagcccaga ccgccagcta aggtcccaaa 550261 gtatacgtta agtggaaaag gatgtggagt tgcttagaca accaggatgt tggcttagaa 550321 gcagccacca tttaaagagt gcgtaatagc tcactggtcg agtgactctg cgccgaaaat 550381 gtaccggggc taaacgtatc accgaagctg cggactgttc ttcgaacagt ggtaggagag 550441 cgttctaagg gctgtgaagc cagaccggaa ggactggtgg agcgcttaga agtgagaatg 550501 ccggtatgag tagcgaaaga ggggtgagaa tcccctccac cgaatgccta aggtttcctg 550561 aggaaggctc gtccgctcag ggttagtcgg gacctaagcc gaggccgaaa ggcgtaggcg 550621 atggacaaca ggttgatatt cctgtaccac ctcctcacca tttgagcaat ggggggacgc 550681 aggaggatag ggtaagcgcg gtattggata tccgcgtcca agcagttagg ctgggaaata 550741 ggcaaatccg tttcccataa ggctgagctg tgatggcgag cgaaatatag tagcgaagtt 550801 cctgattcca cactgccaag aaaagcctct agcgaggtga gaggtgcccg taccgcaaac 550861 cgacacaggt aggcgaggag agaatcctaa ggtgatcgag agaactctcg ttaaggaact 550921 cggcaaaatg accccgtaac ttcgggagaa ggggtgctct gttagggtgc aagcccgaga 550981 gagccgcagt gaataggccc aggcgactgt ttagcaaaaa cacaggtctc tgcgaagccg 551041 taaggcgaag tataggggct gacgcctgcc cggtgctgga aggttaagag gagcgcttag 551101 cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg ccgtaactat aacggtccta 551161 aggtagcgaa attccttgtc gggtaagttc cgacccgcac gaaaggcgca acgatctggg 551221 cactgtctca acgagagact cggtgaaatt atagtacctg tgaagatgca ggttacccgc 551281 gacaggacgg aaagaccccg tggagcttta ctgcagcctg atattgaatg ttggtacagc 551341 ttgtacagga taggtaggag ccttggaaac cggagcgcca gcttcggtgg aggcatcggt 551401 gggatactac cctggctgta ttgaccttct aacccgccgc ccttatcggg cggggagaca 551461 gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa aaggtaacgg aggcgcccaa 551521 aggttccctc agaatggttg gaaatcattc gcagagtgta aaggcacaag ggagcttgac 551581 tgcgagacct acaagtcgag cagggacgaa agtcgggctt agtgatccgg tggttccgca 551641 tggaagggcc atcgctcaac ggataaaagc taccccgggg ataacaggct tatctccccc 551701 aagagtccac atcgacgggg aggtttggca cctcgatgtc ggctcatcgc atcctggggc 551761 tgtagtcggt cccaagggtt gggctgttcg cccattaaag cggtacgcga gctgggttca 551821 gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg caggaaattt gagaggagct 551881 gtccttagta cgagaggacc gggatggacg caccgctggt gtaccagttg ttctgccaag 551941 ggcatcgctg ggtagctatg tgcggacggg ataagtgctg aaagcatcta agcatgaagc 552001 ccccctcaag atgagatttc ccattccgca aggaagtaag atccctgaaa gatgatcagg 552061 ttgataggtc tgaggtggaa gtgtggcgac acatggagct gacagatact aatcgatcga 552121 ggacttaacc atatttttga atgatgtcac acctgttatc tagttttgag agaacactct 552181 caatttgttt ggtggcgata gcgaagaggt cacacccgtt cccataccga acacggaagt 552241 taagctcttc agcgccgatg gtagtcgggg gtttccccct gtgagagtag gacgccgcca 552301 agcattactt ttatcatcgc ggggtggagc agttcggtag ctcgtcgggc tcataacccg 552361 aaggtcgcag gttcaaatcc tgcccccgca accaaatata tggttaaata aggagtgccc 552421 taagggtgca accaaaataa tcctatacaa atatggtccg gtagttcagt tggttagaat 552481 gcctgcctgt cacgcaggag gtcgcgggtt cgagtcccgt ccggaccgcc attaatgtaa 552541 acgaaacgat catgttttcg ttttttttgt gttttctttt actgtatctt ctgcttggtg 552601 tcatagccaa gctttcttta tatcgggaac atcttggata ttccagcaaa attcgataaa 552661 ctaggaagag cacaaatagg cataagcagg gttgaaagga ggttttggtt catggatgaa 552721 tttgatttga tacatagcat tactccgcgg accattcacc attcttccgt tgatgtagga 552781 ataggtgatg atgcagcgct ctacactgcg aaacacggcg ttcaggaaat tgtttgtgtt 552841 gatactatgg tagaagacgt gcacttcaaa ttacactatt cctcacctga agatatcggg 552901 tacaaggcgt tagccgttaa tataagtgat attgccgcga tgggaggcat tcctaagttt 552961 tatctggtat cacttgcggt accttcaaaa tggactgaat ctgaaatcaa ggcgatgtat 553021 gaaggaatga atgaactggc gaaactatat catatggatc tgattggcgg cgatacagtt 553081 tctaccgctg acaaattagt cgttacagtc actgtaatcg gtgaaattga aaagggacag 553141 gcctgtttgc gcagcttggc aaaaccgaat gatattgtgt ttgtaaccgg tgaaatcggt 553201 tcttctgcag cagggctttc tttattgctg gaagagacta atcctcaaaa ctcatctgtg 553261 gaaacggatt actttatcca caggcataaa cggcctgagc caagagtaag cgtcggcaga 553321 ttatgctcga tttttaaacg ggcagcttta aatgatgtta gtgacggatt ggctagtgaa 553381 ctgaacgaga ttgcagaagc cagctgtgtt tcaattgaaa ttgttgaaag catgcttcca 553441 attcattctg atttgcctaa gcttcatcct aactggaaag aatgggcttt gtttggcggt 553501 gaggattttg agctgacagg gacggtttca aatgaggagt gggaagtgtt gaagcaggag 553561 tgcgcagcgc ttcatcttcc cattacaaag attggctatg tcagggaaaa aacaaaatct 553621 aaagtgatcc taaaaacaga tcaaacatca atgatcttag agaaaaaggg atataatcat 553681 tttaaataag acgggtgact cgtgtgaagc aattaaaatg gagaactgta aatccagaag 553741 aaacaaaagc aattgccaag ctgacggcag cgtttgctaa accgggagac gtcctgacat 553801 tagagggcga tttaggtgca ggaaaaacga cttttacgaa aggttttgca gaagggctgg 553861 gaattacacg tattgtaaac agtccgactt ttacaattat aaaagaatat aacgatggcg 553921 tacttcctct ttatcacatg gatgtgtata gaatggaaga tgaaagtgaa gatttgggac 553981 ttgatgaata ttttcacgga caaggtgtct gtctcgttga atgggctcat ttaattgaag 554041 aacagctgcc acaggagcga ctgcaaattg tcatcaaaag agctggtgat gatgagcggg 554101 aaattacctt tactgctgtc gggaatcggt atgaaatgct ttgtgaggag ttaagtagac 554161 atgacaatat tagcaattga tacatcaaat tatacattgg gcattgcgct gcttcgagaa 554221 gacactgtta tagcagaata cattacatat ttgaaaaaga accactctgt aagagcgatg 554281 cctgctgttc attcattgct gaatgattgt gatatggcac cgcaggacct ttctaaaatt 554341 gtcgttgcaa aaggccctgg ttcatacaca ggagtaagaa taggtgtgac gttggccaaa 554401 acacttgcct ggtctttaga cattccaata agtgctgtat caagtcttga gacgcttgcg 554461 gcaaatggcc ggcattttga cggtctgatc agcccaatct ttgatgctag acggggacag 554521 gtgtacacag gtctgtatca atataaaaat gggcttttag agcaagttgt tccagatcaa 554581 aatgtgatgc tggcagattg gctggagatg ctaaaagaaa aggaccgccc tgttttgttt 554641 ttaggccatg atacttctct tcacaagcag atgatcgagg atgtgcttgg aacaaaagga 554701 ttcattggaa ctgccgccca gcataacccg cgcccttcag aattggcttt tctcgggaag 554761 gaaaaggaag cagctgatgt tcatgggctt gtcccggatt acttgcggct ggcagaagct 554821 gaagcgaaat ggattgaaag tcaaaagtag ggtgatagga tgaaaacaaa agcagcggtc 554881 agaaatatgc ggcttgaaga tatagatcac gtatacgaaa tcgaagcatc ctcctttacg 554941 tctccttgga cgaaggattc gttttatcat gagctgctgg aaaatccgta tgctcattat 555001 ctcgtgattg aaaaggacgg ccatcttgct gggtattgcg ggatttggat tgtgatggac 555061 gatgcccaga ttacaaatat agcgataaaa ccagagtatc gcggccagtc tttaggagaa 555121 acgctttttc gctcagctgt tgaactgtgc aaagaaaaag acgcaaggcg gctttcgctt 555181 gaagtgaggg tttcgaatca tcctgctcaa ggcttatata agaaattcgg gatgcagccc 555241 ggcggaataa gaaagaacta ttatactgat aacggggaag atgcgttaat tatgtgggtg 555301 acgataaatg agtgagcaaa aagacatgta cgtattagga attgaaacaa gctgtgatga 555361 gactgctgca gctattgtga aaaacgggaa agagatcatt tcaaacgtag tagcctctca 555421 aattgaaagc cataagcgct tcggaggcgt tgttccggaa attgcttcaa gacatcatgt 555481 tgaacaaatc actttggtta tagaagaggc gtttcgcaaa gctggcatga cgtatagtga 555541 tattgatgcg attgcagtaa cagaaggtcc gggactggtg ggagcgcttc ttatcggagt 555601 gaatgccgct aaagcattga gctttgcata taacattccg ttagtaggcg ttcatcatat 555661 agccggtcat atatacgcga accgtcttgt agaagacatc gtgttcccgg cactggcatt 555721 ggtcgtttca ggaggccata cagaactggt ttatatgaag gaacatggat catttgaagt 555781 cattggggaa acccttgatg atgcggcagg agaagcctac gacaaagtgg cgcggacgat 555841 gggattgcca tatccgggtg gaccgcaaat tgacaagcta gctgaaaaag ggaatgacaa 555901 tattccgctt cctcgcgcat ggcttgaaga aggctcttac aacttcagct ttagcggatt 555961 gaagtctgcg gtgatcaata cgcttcataa tgcatcccaa aaagggcaag agattgctcc 556021 ggaagatttg tctgccagtt tccaaaatag tgtgatcgat gtcttggtaa ccaaaacggc 556081 gcgcgcggca aaggaatatg atgtcaaaca ggtcctttta gccggaggag tagctgcaaa 556141 cagaggcctc agagctgcat tagaaaagga atttgcccag catgaaggga ttacgcttgt 556201 cattcctcca ttagctttat gcacggataa tgctgcgatg attgctgctg ctggtacaat 556261 tgcttttgaa aaaggaattc gcggtgcata tgatatgaat ggccagcccg gccttgaatt 556321 gacttcttat caaagtctca cgagataata gcgtgagact ttttatctgt ttgttattaa 556381 cagacaattc acaatttatc cacatatctg tgagtaatta tagagatatt gatggataaa 556441 gggctgaggt cactgttaat aaagtggata aattcagaat attttgtgga tagtgtgtat 556501 aaagcgctta ctttgtttat ttattagggg atgttctgtg gataaaaagc acctctaaaa 556561 agaggtgctt gactttttta atcttcttct gtggatagtt cttcccattc ggacaaaaga 556621 gattccagct cctgattaag cttctcattg tctgcatgga tagcttgtac tttttcatga 556681 tcctgataga cttcagggtc acatagcaat tcatcattgc ggctgatgtt ctcctcaatg 556741 gtttgaacgg tggtttcaat ttcttcaatc cgacggagtc gttggcgctc tttctttttc 556801 cattcttttt cttcctcgta ggaacgtttg gagtcagact tcactgtagc tggcgtttta 556861 tcagtttcct cttgctgatt cattttctcc aattcaagct gctctgtttt tttctctgta 556921 taataatcgt aatctcccag atactcctct atatggcttg aagaaagctc caatactctt 556981 gtggcgattc tgttaataaa atatctgtca tgtgagacaa ataacagtgt gcctggataa 557041 tcaatcagcg cgttttcgag aacttctttg ctgtctaaat ccagatggtt cgtcggttca 557101 tcaaggatga gaaagttggc tttttgaagc atcagcttag ctagagccaa tcttgctttt 557161 tcgcctccgc tcagtgaatg aactggtttc agcacatcat ctccggagaa taagaaattt 557221 ccgagacacg ttctgatttc tttttctggg agcccggggt actcgtccca cagctcatca 557281 aggacacgtt tagaggaagt caactcagcc tgttcctggt cataatagcc gacactgaca 557341 tttgagccgt aagaaattgt tccctgatct ggttttaggg tgtctattaa tgttttcagc 557401 aatgtcgatt tacctattcc gttagggccg acaagcgcag cgctttctcc tcttgtgagc 557461 atgaatgaca cttctgttaa aagcggcggc tggttttcat agctgattgt gagatcctga 557521 acacgaagga cttcatttcc gctctgtttt gtaatatcaa aatgaaagtt tgcggatttt 557581 tcatcgccaa gcggttttga catgacatcc attcgctcaa gctgctttct gcggctttgc 557641 gcccttttgg tggtagaggc tctcgccaga tttcgatcta cgaagtcctg cagctttgca 557701 atctcgtcct gctgcttttc atacattttc agatcttttt catactgcgc ggctttttgg 557761 tcgagataag cgctgtagtt gccgtgatac tttttgcttt ctgctcttga tacctcgtat 557821 acctggttta ctactttgtc caaaaagtag cggtcatgcg aaacgatgag aatggcgcct 557881 gaatagcctt gtaaataatg ctcaagccag gtaagcgtat caatatccag atggtttgtc 557941 ggctcatcaa gaatgagcaa atcaggctgt gttaatagaa gcttacctaa agccagtctt 558001 gttttctggc ctccgctgag gctttgaacc tgtgtagaat cgtcaaaatg gctgaagccg 558061 agaccatgca gcacagatct aacatccgct tcatattgat aaccgccttt atctttgaat 558121 tcctgctgaa gacggtcgta ggttttcatg atgctttcta attcacccgg gtcagctgcc 558181 gccatttttt cttccatagc ccgcatttcc ttttccattg cttttaagtg gtcaaaaaca 558241 gtcagcagct cttcttttat ggtaagctta gaatccaagc cagtatgctg ggcgagatat 558301 cccattgtaa tatctttcgg tttaataatt tcgccctttt catacgaaag ctggcctgcg 558361 ataattttaa ggagcgtgga ttttccggcg ccatttcttc ctacaatggc gatgcgatca 558421 cgatttctga cttccagctt tatattgttt aaaatagtat cagcaccaaa tgatttggac 558481 agctgattaa cttgtaagat catcatatta tttcacctct gctataataa gttaagtgta 558541 gcttatgaac cagaagtcag caaacaatac attggccata taagacatag agaagaaaat 558601 agtgtatgat ctgtttaagg agcgttttaa tatgaatgga ttttctcatt ttaatgaaca 558661 gggcagagcc cagatggtgg atattagcga aaaatcttcg actgtccgta ctgcggcggc 558721 tgtttcaagc gtacacatga agaatgaagt gtacgagaaa atacaaagtc acgatatcgg 558781 caaaggagat gtactggctg tcgcacaggt ggcaggcatt atggccgcaa agcaaacgtc 558841 gaatatcatt ccgatgtgcc atccgctttc attgagcggg gtagatatat cgtttgactg 558901 gaaaataaaa gaagcagaag ttatacttca tataaaagca caggtcaaaa cgaaagggag 558961 tacaggtgtg gaaatggaag cgctcacttc tgcatcggtg tgcgctctta ccgtttacga 559021 tatgtgcaag gcccttgata agggaatggt catcggccct actttcttgc tggagaagac 559081 aggcgggaaa aacggtgact ttaaaagaga actatccgag tataatttgg aggaccaaaa 559141 atgaataagg atcaatcaaa aattccgcag gcgacggcga aacggctgcc gctttactat 559201 cgctttttaa agaatctgca tgcgtcagga aaacagcgtg tatcatccgc tgaactcagt 559261 gatgccgtaa aggttgattc tgccacgatt cggagggatt tttcctattt tggagctctt 559321 ggcaaaaaag gatacggata taatgtggat tatttgctgt cttttttccg gaaaacgctt 559381 gatcaggatg agatgacaga cgtcatcttg attggtgtcg ggaacttggg aacggcattt 559441 cttcactata atttcacaaa aaacaataac acaaaaattt ctatggcttt tgatataaat 559501 gagagtaaaa taggaactga ggtaggcggc gtgcccgtct ataaccttga tgaccttgaa 559561 caacacgtaa aagatgaatc agttgccatt cttacagtgc cagcagttgc cgctcaatcc 559621 attacagaca gattggtcgc attaggaatc aagggaatcc ttaattttac gccggcccgt 559681 ttgaatgtgc cggaacacat tcgaattcat catatagatt tagcagttga gcttcagtca 559741 ctggtttatt ttttgaagca ttattcagtt ttagaggaaa tcgaatagag ggaaaggagg 559801 agcccaaata tgccgatcgg tcctggaagc cttgctgtta tcgcaatcgt tgctctgatt 559861 atcttcggtc ccaaaaagct gcctgaattg gggaaagcag cgggagacac acttcgtgaa 559921 tttaaaaacg ctactaaagg attaacgagt gatgaagagg aaaaaaagaa agaagatcag 559981 taagttagga tgacacgaat gaaagtgaat caaatgtcgc tgctggagca tattgctgag 560041 cttcgaaaac ggttgctgat tgtagcgctg gcgtttgtcg ttttctttat tgctggattt 560101 tttttagcaa agccgattat tgtgtatctg caagaaacag atgaagcgaa gcagcttacg 560161 cttaacgcgt ttaacctgac agacccgctt tatgtgttta tgcaatttgc gtttatcatc 560221 ggcatagtct tgacctcgcc ggttattctt tatcagcttt gggcttttgt gagcccgggc 560281 ctctatgaga aagagcgcaa agtaacgctc agctacattc cggtctctat tttgctgttt 560341 ttagcgggct tatctttttc atattatatt ttatttcctt ttgttgttga ttttatgaag 560401 cggatttctc aggacttgaa tgtcaatcag gtgatcggaa ttaatgaata ttttcatttt 560461 cttctgcagc tgacgattcc gtttggactg ctgttccaaa tgccggtcat cctcatgttt 560521 ttgacaaggc tcggaattgt gacaccgatg ttcttggcga aaatcagaaa gtatgcgtat 560581 tttacgctgc tggtgatcgc agccctgatt acaccgcctg agcttctgtc ccatatgatg 560641 gtcacagtcc cgcttttgat tttatatgaa atcagtatcc ttatatcgaa ggccgcttat 560701 cggaaagcac agaaaagcag tgctgccgat cgggacgtgt cttctgggca ataataaaaa 560761 atccatttct catgcgagaa atggattttc tttatttttg gttctttttg attttaaatg 560821 aaaaggcgaa catcttaaaa gaaatgctga tgttgtaagc ggcgaacacc atcagcagga 560881 tggagtaaaa tgaccacatg ctgcctggcg agcttgcggc aagataagta aagatgcacc 560941 ctacggcaaa gtagatcatt ccccaaacta ccgggtttct cataaaaata atcctccaat 561001 aatcaattgc atttgtgtgc tctgctgttc aaggtaatta cgaacaggct caagctgcat 561061 gatgacgacg aatgtattca tcattaaatg ggcgaaaatc ggcacccata tccgttttgt 561121 tctcgcatat aaaaaggcaa aggtaaagcc cattgctgta tatagaagga gatgcttcaa 561181 atcagcgtga acaataccga agataaccga gctgatcagt cctgcgaaaa agaaattcgt 561241 tttttcgtac agcgcgccga aaatgatttt tctgaagatg atttcttcta atataggccc 561301 gacgatggaa gaaacgataa tcatgagcgg gactgcctga atgacatcca gaatcgcttg 561361 tgtattttct gattctcttc cgatgccaaa aacataatat tcaatagagc ctgctattcc 561421 ttgagagaaa agggcaatga aaaaaccggc tatcgcccaa aggatagaaa gtccgattga 561481 gtccttctgt ccgtttcgca gcgtttcttt cggaacggtt ctcagaatga gcagaacaac 561541 aacgagacag gcgataaagc tgataacgga ccataatcct tgtgcatgca gcatattttc 561601 atctgtaggc tgtcctccgg cataaccgaa tttaaataac aagggaatcg cgattaatgc 561661 ggaaaactgc atgatgatat atgtcaaaat aataaaccaa tactgttttc tcaaatggta 561721 tgtactcctt tgttaagtgg gtttcgttca tctacagcta ttgtaacata atcggtacgg 561781 gggtgaaaaa gctaacggaa aagggagcgg aaaagaatga tgtaagcgtg aaaaattttt 561841 tatcttatca cttgaaattg gaagggagat tctttattat aagaattgtg ttagcactct 561901 ttagtgctga gtgctaaaat tacatattca tactattgag gaggttattt cattgttaaa 561961 gccattaggt gatcgcgttg tcattgaact cgtagaatct gaagaaaaaa ctgccagcgg 562021 aattgtgttg ccggattctg caaaagaaaa accgcaagaa ggcaaaatcg tggcagctgg 562081 ttcaggtcgc gtgttagaaa gcggagagcg cgttgcttta gaagtaaaag agggcgaccg 562141 cattatcttc tcaaaatacg caggtactga agtgaaatac gaaggtactg aatacttaat 562201 cttacgtgaa agcgacattt tagctgttat cggctaattc ttaaataaac aatacttaaa 562261 acatttgagg aggtcttgta aacatggcaa aagaaattaa gtttagtgaa gaagctcgcc 562321 gcgcaatgct tcgcggtgtc gatgcacttg ctgatgctgt taaagtaact ttaggaccaa 562381 aaggacgcaa cgtggttcta gagaaaaaat tcggttctcc gttaatcaca aatgacggtg 562441 taacaatcgc taaagaaatc gagctagaag acgcgtttga aaacatgggt gctaagcttg 562501 ttgctgaagt agccagcaaa acaaacgacg ttgccggtga cggtacaaca actgcaacag 562561 ttcttgcgca agcaatgatc cgtgaaggcc ttaaaaacgt aacagcaggc gctaaccctg 562621 taggcgtgcg taaagggatg gaacaagctg tagcggttgc gatcgaaaac ttaaaagaaa 562681 tttctaagcc aatcgaaggc aaagagtcta tcgctcaggt tgctgcgatc tctgctgctg 562741 atgaggaagt cggaagcctt atcgctgaag caatggagcg cgtaggaaac gacggcgtta 562801 tcacaatcga agagtctaaa ggcttcacaa ctgagcttga agttgttgaa ggtatgcaat 562861 tcgaccgcgg atatgcgtct ccttacatgg taactgactc tgataagatg gaagcggttc 562921 ttgacaatcc ttacatctta atcacagaca aaaaaatcac aaacattcaa gaaatccttc 562981 ctgtgcttga gcaggttgtt cagcaaggca aaccattgct tctgatcgct gaggatgttg 563041 aaggcgaagc acttgctaca cttgttgtga acaaacttcg cggcacattc aacgcagtgg 563101 ctgttaaagc tcctggtttc ggtgatcgcc gtaaagcaat gcttgaagac atcgctgtcc 563161 ttactggcgg agaagtcatc acagaagatc ttggccttga cctgaaatct actcaaatcg 563221 ctcaattggg acgcgcttct aaagttgtcg ttactaaaga aaacacaaca atcgttgaag 563281 gcgctggcga aacagacaaa atttctgccc gtgtgactca aatccgcgct caagtggaag 563341 aaacaacttc tgaattcgac agagaaaaat tacaagagcg tcttgctaaa cttgctggcg 563401 gcgtagctgt catcaaagtc ggcgctgcga ctgaaactga gctgaaagag cgtaaacttc 563461 gcatcgaaga cgccttgaac tcaactcgcg cagctgttga agaaggcatc gtatccggtg 563521 gtggtacagc gcttgtaaac gtatataaca aagtcgctgc agttgaagct gaaggcgatg 563581 ctcaaacagg tatcaacatc gtgcttcgcg cgcttgaaga gccaatccgt caaatcgcac 563641 acaacgctgg ccttgaagga tctgtcatcg ttgagcgcct caaaaacgaa gaaatcggcg 563701 taggcttcaa cgctgcaact ggcgaatggg taaacatgat cgaaaaaggt atcgttgacc 563761 caacaaaagt tacacgctca gctcttcaaa acgctgcgtc tgtagctgca atgttcttaa 563821 caacagaagc tgttgtcgct gacaagccag aagaaaacgg tggcggcgca ggaatgcctg 563881 atatgggcgg catgggcggt atgggtggaa tgatgtaata aagggatatt aacccttata 563941 catcaatgtt ttaaccgtct taaaaaacta gacaaagcgt gaataaaaaa agagaaggtc 564001 tttcatcagt ttactaaact gttgggagac cttttctcca tattagcggt catatgagca 564061 taaatgtcca tcgtcgtatt tatgtccgaa tgaccaaatt gttgctggat ttctttaatg 564121 cctactcctg cctcaattag taaggaggta tgggtatgcc taaaagagtg gggggtgaca 564181 ttctttttat cccagctttt ttgagcagcc gtttaagtct agtctcaata acctttctta 564241 attgcggatg accatcctcc cgctcaaaaa taaatgatga gtcttgataa atcaatctat 564301 ttttaagctt aatttcattt tgataaattt tatttttttt tagtagattg acatcgtttc 564361 atcaattcga acgatatcaa cagatcctgt tgttttaggt gttagcaatt ggtatttttc 564421 aatttgattg ttaggggtgt atagggtctt tgtgacctgg cttatcattg aaatctgtcc 564481 attttaaagc aagaagttca ccaattctta ggtcggtcta ggcaagtacg gtaaagacca 564541 aatggtccat ttctagcccg tcagattgag cgagctttag aaaatgtgtc agcacctctt 564601 tttccaatgc tttgttgctt cttgggtaat tgaaaatccc cagttgggtt cattttaata 564661 atcccttgag ttttagcttt tcggaaaatc atacggccgc aggcatgaat acctcccaaa 564721 caattgtgac tgtattgctc gttcagttct aacgtgcggt cttcatacat ttttttgtgt 564781 tttgctaatc gggtattgac ccaatactgc gataaaatgc atcattttct tttcactggc 564841 ccgtacactg cttattttta ccccactccg gttgtaaatc ttaagccaac cttttgcaaa 564901 tgttttgaag ggcatatctg actccttaat aaaagtcccg ttgtcgtttt ggagttctac 564961 gtgacgggct gctactgggg cttctttctt tgttttaaat cttcctttgg atatttctag 565021 acgttttttg gttaaagggt caatgcctag tagatatgat aactccacgt cttaccgcat 565081 tgcttgagtt ttgccattta tttgtcccta actaattttt tttcatcaaa ttggtcttta 565141 agtgagttta ataatttttg tttctctcga ctggtcaata attgcccttc atatttcaaa 565201 agattggata aatttgagat ggaatcaatc ctgatggatg gtaccgtaga ctttaataag 565261 aaacgaaagg ccaactgcga cttcagttgg cctttcctat ttataataaa gaaattgagt 565321 gagattgctg acagaactac gtactactcg ttttctttag ttgcccttgc taatcgttca 565381 acctctcccc gaatcccaat cgcaggctcc cacgaatcaa tcaaacgaat cgccttctga 565441 ttagattcca ccgctttcgt tttctctcct ttacgataca acagctgcgc cattccgtag 565501 tgatagtaga tcagttcaac ttgattggcg ttatgtttgt catagagcat ttgctcaaag 565561 gcttcttccg ctttttcaaa ctgatcacat ttcacgtaag cgacacccag attgaaatag 565621 gcttctatcg ttttttcgcc gccgtatgtg gagctgattt catttgccgc ttcgtataat 565681 tgaatggctt ctacatgata acctctcgca aagcttaagt caccgcgaac caatagaact 565741 ctgtgttgaa tggtagggga aatcggttga ttttcgattt cgtttaaaat tgtctctgct 565801 ttttcctgtt gcccgtcttt taaaaacagc cttgctttga gtgcatgtcc ccaaaccttt 565861 agatcatagg catcgtgagc gtctgattgt tcaagaatct tcagcccggc ttctatttgc 565921 tgaagcgctc cgtctaaatc attgacttcc atcaatgccc agcctgaggt gtcgattcgg 565981 aagtacgctt ctcgtgtgtg ttggcctaag tgatgggcgg cgtcggccgc tttgcgtccg 566041 tattcgattc gcaggggcag gttgattctg cttagaaaat ggctaatgcg ggtgatgagt 566101 tcgattagga tttctttttg ttcagtttca cttgcccatt ggatgacctt taagatgttt 566161 ggccattctt gtttcatttg atctaagttc cgtcccagca ggtagctcca atagatagag 566221 ttgggctgtt cccgctttaa atgggtttcg gcataatcaa tataatagtg cgcccagcga 566281 ttgcgggctt ctttttcata ttcgtgctgt tcggacaagt gctgttctcc gtaagcgaca 566341 acggtttggt gcgctaagta ttgtgtcctg ccttggcttc gttccggctg aatcagcgca 566401 tatgaccgca tttgttccat agcgtaatga aaacggcggg cgtctaatcc ggctgctgcc 566461 gccaggcttt tttcatcagg cggcttgctg aaaaagcaaa gcgtctgcca gagctttcgc 566521 gtatcttcat tgcatctatc ccaggtgcgg ccaaagagga attcaaacaa ttccagcagt 566581 gagtagcctg cttttccaag ctcatgaatc agctgctgag cggggatgtc atcgtctgac 566641 atataggcaa tgctgagtgc catggctttc gggtttccgg cagtcgctga aatgaattcg 566701 tttttcaggt cagatgatag atgtaacagc tgctccagct tttcccgttt acgtgggagg 566761 ttgcatgttt gtaagcagtg atgcacttct tgttgaaaaa attcgtgggc atctgtttgg 566821 tcaagaccgc ttagctgaat ggctgtcatt tctccgaagc tttcccgata agtttgcttt 566881 acgttttccc gcgctgtaag gagaactttt acgccttgcg gaaggctggt gataaattca 566941 tgaatgtcac gttctgcagt atcaatgctg tcaacgatca gcaggatcgg tttttctcta 567001 gtgtaattgg ctaacgcatt gcggacgaca aaccgtttta cattgattga tttatcgatt 567061 tgttctttgc gtccgagctg ataggcgatc gtatttaaaa aatcgctaaa gcttaatcct 567121 ttccaatcag cgctgaccca gatgatgctg ttgaatgccg gccaaactga agtatcgtcg 567181 acacaggaat aggcggcttc aagagcaatt gtggtttttc ccatgccggc ccagccggtg 567241 attaaacaga ctggtgatgg agaaagcatc cattgccgta tcgcttccat atcaaagctg 567301 cgtccgataa agcgtccgga ccagcgtgag ggtaaattat gcgtgatggg ctgttctgta 567361 agcgcattcg tttcttggcc gggtctgtca tgaaacagcc gttttactac attttcaatt 567421 tcgccttcac tcggagcccc gaataatccg tcttttcgca gtattttcgc ttttttcaaa 567481 caggatgctg cccatacagg caatgcgggt ttgatgactg ggatagtggt ggcttccagc 567541 aagtcggtca accactcgat atccaagtcg gtcttttcga gaatgatcca gatcattccg 567601 aacagttttc cgtcgtcgat tcttccggga atgtagtttg cccccatctg tccgatccag 567661 cttttgatcg tgtttgggga gactcccagc tggagtgcga ttttatctat gtaagactgt 567721 cctgtttttt cattcttttt ccttctgact ttataatcag gatgaagttt tagcgttttg 567781 acgccaggtg ccagcatttg tgcaaattgt tttcggtttt caagttcagc cataagcctg 567841 cacctcctat tagtactatt ttatcaatcc agcgtttttt gtatatgaaa aaataaaagt 567901 acagtgccgc tgtcctttta tacagcagga aaggctgttg aacgtgttaa aaagcagata 567961 aaatgggggc agtaacagag aaaacaaaaa tgtatgcact tacattttat tttctaaaga 568021 aaggaacttg ccaaatgact cacacagtac ctcaaaacat gaaagcggct gttatgcaca 568081 acacaagaga gatcaaaatt gaaacattgc ctgtgcctga tatcaatcat gatgaagtgt 568141 tgattaaggt gatggctgtc ggaatttgcg gatctgatct gcattactat acaaatggcc 568201 gaataggcaa ctatgttgtg gaaaaaccat ttatccttgg gcatgaatgt gcgggtgaaa 568261 ttgccgctgt cggatcatct gtcgatcaat tcaaggtggg agaccgcgtc gctgtagagc 568321 cgggtgttac gtgcggacgc tgtgaggcgt gcaaagaagg acgctataat ctttgcccgg 568381 atgtacagtt tttggctaca ccgccggtag acggtgcgtt tgtccaatat attaaaatgc 568441 gtcaggactt tgttttttta atcccagact cactttctta tgaagaagct gctttgatcg 568501 agccgttttc tgtcggtatc catgcggcgg ccagaacgaa gctacagccc ggatcaacga 568561 ttgcgattat ggggatgggc cctgttgggt taatggctgt tgccgcagct aaagcatttg 568621 gggcaggcac aatcattgtc accgacttag agccgctgcg gttagaagct gcgaaaaaaa 568681 tgggagcgac tcacattatt aatatacgtg aacaggatgc acttgaagag attaaaacga 568741 tcacgaatga tagaggcgtt gatgttgctt gggaaacagc agggaatcca gcggcattgc 568801 aatccgcact ggcttctgtg cgccggggcg gaaaattggc gattgtcggt ttgccttcac 568861 agaacgagat tccgctcaac gtgccgttta ttgcggataa tgagattgat atttacggga 568921 tcttccgtta tgccaatacg tatccaaagg gaatcgaatt tcttgcttca ggcattgtgg 568981 acacgaagca tctagtaacg gaccaatatt cgctggagca gacgcaagat gcgatggagc 569041 gggcgcttca atttaagaat gaatgtttaa aagtgatggt gtatccaaat cgctgagtga 569101 acagggagga tcttcgtatt ctccctcttg tttactggaa atgaaaacgg attcttgggg 569161 tgggaaatga tgattggaac agaaaaagta acggcattga aggcgaagca tcagtcaaaa 569221 tccagcaccg gcctgtcctg gtttgaacga atcggttatg gattcggcga tatgtcgtat 569281 aatattatct ttcagtttgt aaacgcatac ttattatttt attatacaga cgtcggcggc 569341 attcagcctg cggtaatcgc aactttgttt cttgttgtgc gtgtgctgga tgctattttt 569401 gacccgatca tgggattgat tttagataaa acgaatacaa ggtggggaaa agcaaggcca 569461 tatttgctgt gggtggcatt tccttttgcg ctattcacat tcttatgttt cacgacgcct 569521 catttcggtg agaccggaaa tatggtatat gcgtatgtca cttatattct gcttgggatg 569581 tcctttagta tgcaaacgat cccggtgaac agcttaacgg ggcggatgac gaattcggtg 569641 gaggaacgaa cggttctgac cacaacccgg atgattttgg tgtatatcgg cattctttta 569701 tccatttcct gtgcgacacc gcttgcaact gctatcggag gagaggatca ggcgtttgga 569761 tttcagatga cggcgctcat ctatgcggct gtcagcatcg ttttgaatct atttagtttc 569821 tttactgtac gggagcggat tcagcctaaa aagagaaaaa aacaagggat caaaaagacg 569881 ttatccgttt tattcaaaaa caaacccttg ctcatgttaa tttcatcatt tttggctttt 569941 gcgatcgggt ttaatattaa gctcagcacg atggtgtatt attttacgta taacgtaaac 570001 cataaagagt tcgtgtttat gggcaccgtt ttatttttcg gggcagcgct gatcagcaat 570061 ttgtttattc ctttcttttc tgagaagtgg ggcagaaaac aagtcatgat tatcacggca 570121 gctctatcgc ttatttctta tgccggcctg cattttacgc cgtattcttc aattccactc 570181 attttcattt ggcttttcgc ttcgggattt ttcacaacgc ctttaaatac gcttgcttgg 570241 ggaatggttg cggattgcgt cgattatgcg gaatggaaaa ccggaattcg cgcggatggt 570301 gttgtgattt cgagcatgag ctttattaat aagctgggtg ttgcgttagc cgggtcattt 570361 tcggccattt atttaggaat cgccgggtat gtggcgaata cagaccagac agttgcgtcg 570421 ttgaatgcga ttaaaaatat gaatgctttg attccgggat ttttcatttt gctttctatt 570481 attcttatcg ccttctatcc tttaacggaa aaaagatata aacacatcat ctctgagctg 570541 gagcaaaggt ctgcgagata aatagatgta aaatttttaa tattcaatgt tgtatttatg 570601 gcaaaaagta atatactgag actgtaatct agactttata aatgagtgtg ataatatgcg 570661 tagtcattct gtagtttgta ttggggaatt gttgattgat ttcttttgta ccgatgttga 570721 cgttgattta atggaagggc gccaattcct gaaaagtgcc ggcggggcac cggcgaatgt 570781 gtcggcagcg attgccaagc tgggcggaga cgccgctttc agcggaaaag taggaaagga 570841 tccgtttggg tattttctga agcgaacatt ggacgctgta catgtcgata cctctatgct 570901 ggtgatggat gagaaagcgc ctacaacgct tgcttttgtt tcattaaaac aaaatggaga 570961 gcgtgacttt gtttttaata gaggcgcgga cgctttgttt acgctggagg acattgacca 571021 ggaaaaacta aacgaagcga aaatccttca tttcggctct gcgacggcac tgttatcgga 571081 tccgttttgc tcagcctatt tacggttgat gtcgattgcg aaagacaatg gacagtttat 571141 ttcgtttgac cctaactacc gtgaagattt atggagggga agagtctcag agtttgtaag 571201 tgttgcgaaa aaagcgatcg ctgtaagtga ttttgtgaaa gtcagtgacg aggaacttga 571261 gattatcagc ggtgtgaagg atcatgaaaa gggagttgcg atccttcatg agatcggagc 571321 caacattgtc gctgtgacac ttgggaaaag cggaacgctt ctttccaatg gaaaagaccg 571381 tgaaatcatt ccaagcattc cggtgacatc aattgactca acaggggcgg gagatgcttt 571441 tgtcggtgcg gctttatatc aattggcaaa cacggatcag attcaatctg tagatgctga 571501 ttttgtgaaa ctgcgtgaga ttgtggcgtt tgccaataag gtcggagctc ttgtgtgcac 571561 taaaattgga gcgattgatg cactgccgag tttggatgag attggagttt ctttgtaaat 571621 cattgaagat gtttcttgaa agtctttgga cttttggggg catctttttt tattgcttac 571681 atttttgttc aggtaaaaag ttgtatattt tttgtttgaa atgtcatttt ttattaaaaa 571741 agtgaaactt ttaacgataa taaatagtat atgtaacaag ggttaccgaa ttagctttag 571801 gaggaacgat ataatgagta taattggaag atttaaagat attatgtctg cgaatatcaa 571861 tgctttattg gacaaggctg aaaatccgga gaaaatggta gatcaatatt taagaaatat 571921 gaatagcgat ttggctaagg ttaaggcaga aacagcagct gttatggctg aggagcagag 571981 agcaaaaaga gaatatcacg aatgccaggc ggatatggaa aagatggaaa gctatgcaat 572041 gaaggcgctg caagccggga atgagagcga tgcgagaaaa tttcttgaaa gaaaaacatc 572101 tttggagtca aagctttctg agctgcaggc ggcgaatcaa attgctgcaa ccaatgccgc 572161 acagatgaga aagatgcatg acaaattggt atctgacatt ggagagctgg aagcacgcaa 572221 aaatatgatc aaggcgaagt gggcagtagc gaaaacgcaa gaaagaatga acaaactggg 572281 cgcttctgtt tcaagtacaa gccaatcaat gtctgcattc ggccgaatgg aggacaaagt 572341 aaataaggca cttgatcagg ccaatgcaat ggctgaactg aacagcgctc cgcaggatga 572401 tatggctgat ctgtctgcaa agtatgacac tggcggttca agccaggttg atgatgaact 572461 tgcggcgtta aaagcgaaaa tgatgctcga taagtaatac ataggaggcc gcagctttcg 572521 gctgcggcgt cattttatca taaaatgtga gagggaacgg taatgataat atcttataag 572581 tgtccgaact gcggcagtga tatggcattt gacagtgaaa ccggctcgtt atcctgcagc 572641 agctgcggaa gacaggacaa tattgaaagc cttccgaaag aaaacattgc ggcacggttt 572701 tctgatgatg aagcaaaaga atatcaatgt aaaaactgcg gtgccgtttt gatcacggaa 572761 gctgaaacga cagcaacgac gtgcagcttc tgcggaggtg ctgcaatact tgccgatcgt 572821 ttatcaggac atttggcgcc ggcgaaggtc attccattta caatcagcaa gcaagaagcg 572881 gagcaggcat ttcgaaagtg gtgcaaaaaa ggccttctga caccaagagg tttcatgtct 572941 gctgatcgta tcaaaagcat caccggcatg tatattccat tttggatgtt tgatttaaat 573001 agtgaagtac aggtgagagc aaactgtacc agagtccatc aatatgaaga aggggattat 573061 atttgcacgg aaacagagca ctttgaagcg tttcgtgata tcaatctcga ttatttgaaa 573121 atccctgtcg atgcctctga aaaaatgaaa gacgaattaa tggacaaatt ggagccttat 573181 tcatacgaag agctgaagga ctttcaaacg gcatatttgg ccggttatat tgcggaaaag 573241 tacaattata ccgatgagga gctttttccg agggcaaaag agaaaatcag cagttatata 573301 gattcataca tccattctac tttttccgga tatacgtcag tcaatgtgag ggacaaacat 573361 attcacacga aaaacgtgaa cagcttttac gttttgcttc ctgtttggat ggtcagttac 573421 gattatgaaa gagcggagca tatctttgcg atgaacgggc aaacaggaaa ggtcgttgga 573481 aagccgccga tcagtcgagg aaaagtggct gcatggttta gcggaatagc aggcgggaca 573541 tttcttgcgt tgaagctcgt ctcattgatg atgggaggcg gattttgatg cgtggatttt 573601 ttgggaaagc gatctttgtt gtgctggctg ttttcatcat gatgccttta ctgggtatcg 573661 aagcggtaag agcctctgaa ttgcagcagc atgtgtacga tcgcgctcat ctattgtcaa 573721 aagcggagat cggaaaactt gaatctctct cggcaaagct gggtgcaaag agggacactg 573781 atttcatcat tattacgacc aaaagcacaa acggtgaaga tattgcagac tataccggcg 573841 atttttatga tcgttacgga aaaggcagta cagccattct gacgattgat atgacaaaca 573901 gagaagtgtt tatcgcaggc tttaaaaaag ccgaacagta tttggacaac agcaggctca 573961 atagcatcag aaatacgatt tcatctgatt tatccaatga aaattatttt gaagcttttg 574021 agacatatat tcagctttcc tataaagata tgggcataaa accgggagta aaccctgaca 574081 acatattctt tacatggtgg tttcagctga ttgctgccat cgcagtcggg ggaattgcgg 574141 tttcaatcat gctttatcat gcaggcggca aagtaacggt taatggaagt acatatatgg 574201 atcagcgtac gtctgatgtg attgatcaat acgacactta tattagaacg actgtaacaa 574261 gagaaagaaa accatcagat aaagacagcg gcagcgatgg cggtgttacg aaaggcggca 574321 cgtcatacag tgggagccgg ggcagttttt aaatgtaaga aatagagaaa gggagaggcg 574381 taatgtcgtt tttcagaaat caattagcga atgtagtaga gtgggaagaa tttagagatg 574441 atatgatttt ttataaatgg aacaatcgtg aaatcaaaaa agggagccgt ttaatcattc 574501 gtcccggaca ggatgctgtc tttttgaaca atgggcgggt tgaaggagtc tttcaagatg 574561 atggcgatta tgatattgaa tcagaaatta ttccattcct ttcaacgtta aagggcttta 574621 agtttggctt taacagcggc atgcgagctg aggtgctgtt tgtcaatacg aaggaattta 574681 ccgtaagatg gggaacaaaa caggcgataa atattccggc agcgggaatg ccaggcggga 574741 tgcccattcg cgcaaacggc acatttaatt tcaaggtgca ggactatatc agcctgattg 574801 ataaaatcgc tggcgtgaaa gatcaatatt ttgtagagga tattaaaacc cgtatcattt 574861 ctattctgga tcagcttctc atgaagtgga tcacaagaga agggaaagat atgtttaatc 574921 ttcaagcaaa cgcttttgat attgccaagg gaattcaaga ggacttagat atgcaattaa 574981 taagcgacgg gatgacggtc actggttttc aaatcatgag ctttaattat cctcaagagg 575041 ttcaagatat gattacaaag aacgcttcct acggtatggt tggggatgtg aacagatacc 575101 agcaaatatc aatgacggat ggaatggcat ccggaaagat gagcggaagc ggagcggctt 575161 cggatatggc tggaatgatg atgggaatga atatggccaa tcagatgatg aaccaaatga 575221 atcagaatca gcaggcacag tcatcaggcc cacagtcaac tggcagcgga agcaaaccga 575281 atttctgtcc aaactgcgga acaaaaacgg gcgaagccaa tttttgtccg aattgcggcc 575341 agaagcttgt ataagaatca tacagtgaaa agtccggagt gatcagcact cgggactttt 575401 ttatttagga gaataagcat tacctattgc ttgctcctga acaggccatt ttcgagcccc 575461 cgcttggata attcccagca gcaattgacg acgttccttt attgaattga cggcaatttg 575521 aaatgtttgc tttgataaag ccggtatgcc tgattgttga agctttgaga tgtctggttc 575581 tggcggcgct tgttctgcag gatggatata ggcagtatga acggtatcca gatagttttt 575641 gatacttgag cgcgcttctt tgatatgaag ctgattcggc tgatattgtt caggaattcc 575701 gtatttgaaa atggttagag cctcatccaa tacagcaaca gctataatgg atgattcctg 575761 atgctgcgtg ctgtggtaaa aatgaaggat ggggaaggcg ttatgctgag cggtcagctt 575821 tcccagttct gatgaggcag cgacaagaag aaaatcaatg tcgtgaaaat ctttgccatt 575881 ccatgcatta tggacgattt cagttccgtc atgccctaga cttaatacac tttgggcaaa 575941 ggagcgtttt tgattaaccg cactcaagac ggaaatcaaa tacgtgacag aaaatgtgat 576001 ggtaagcagt ccttgagctg tttcaataat cgtgacaagc ttccataggc ctccgttcgg 576061 agcgaggtcg ccatttccta atgtaaacat gacatagccg gaaaaataaa ttcggtctga 576121 ccaggaagcc ggttcttttg attgagtttc cataagtgag tgagggtcac tcgagtaaat 576181 caaaacccac ccgctccaaa atagactgat ccatatcact aacgtcaggc ataacagcag 576241 aggaccagcc atacttagaa cctttgcgtg gtcaccgctg attttgcggc agcccttcca 576301 cagccaggca gacaggcatc ttgtgatcgg gccggcaccg ctctctaacc ataacgtggt 576361 ccataaaaaa tcaatcatcc ccgctgtcaa taataaaagg cctgcaatga tataaccctc 576421 attcattttg gttgcctccc ttaagtcagc cttcttttat tttcttctct atttcctttt 576481 atcctgagtc tgaaacaatt gaacgaatgt ttgattttac agagaaaaat aggtgggagt 576541 tacccaacac ttactcattt ttcaatatga acagaaaatc acaagatttt tgacttgatt 576601 cacacatttt catgaagaaa aacgttcatt ttccccttga attggtgatt ttccttttat 576661 agagtaaaaa attttcagaa atttatattg actgaaagcg tttttataat tatgataata 576721 tcagatataa caaaaatgtc actataacat cactacaatt gaactattaa gtgactaata 576781 aataccaaat gaacgaggtt atgcacaaag aaatgaccat tgttctttta acgagaaatg 576841 aaatcgcttc catagggatt gacatgctaa gaagaaggga aggttatgag gttattggat 576901 aaaaacatga acaactattt tctgaagcct gcttacgaaa tgtgaggaag gcagcagccc 576961 tggaataagt ttttgacata cgcattttga aaaagactgg gggaaacagt atgaataaac 577021 aaggaaatca aatgtcattt ttacgtacaa ttattttagt ctccactttc ggcgggcttc 577081 tttttggcta tgataccggt gtgctcaatg gagctttgcc gtatatggga gagccggatc 577141 agcttaatct caatgccttc acagaaggcc ttgtcaccag ttcacttctt tttggagcgg 577201 cactgggtgc tgtgtttggc ggcaggatgt ctgattttaa cggccgccgc aaaaatattt 577261 tgttcctcgc tgttatattt tttatttcaa cgattgggtg tacgtttgca ccaaatgtta 577321 cggtcatgat tatttcccgt tttgtgctcg gtattgcggt tgggggtgca tccgtaacgg 577381 tgcctgccta tttagcagag atgtctcctg tggaaagcag gggacggatg gtgacgcaga 577441 acgaattgat gattgtatca ggacagcttt tggcctttgt ttttaatgcg atccttggaa 577501 caacaatggg agacaactcc catgtgtgga ggtttatgct ggtcattgcg tcacttccag 577561 ccttgttcct gtttttcggc atgatcagaa tgcccgagag tccccgttgg cttgtttcta 577621 aaggaagaaa agaagatgct ttgcgtgtat tgaaaaaaat cagggacgaa aaacgggcag 577681 cagctgagct gcaagaaatt gaattcgctt tcaaaaaaga agaccagctt gaaaaagcga 577741 catttaaaga tctttcagtc ccatgggtgc gccgtattgt gtttattgga ttagggattg 577801 cgattgtaca gcaaattaca ggtgtgaatt cgattatgta ttatgggact gaaattctaa 577861 gaaattccgg tttccaaacg gaagccgctt taatcggaaa tattgcgaat ggcgtgattt 577921 cggtattggc aacattcgtc ggaatctggc tgctgggaag agtggggcgc cggccgatgc 577981 tgatgacagg cttgatcggt acgacaacag cattattgct aatcgggata ttctcacttg 578041 tacttgaagg atcaccggca cttccgtatg tagtcctgtc attaacggtc acatttcttg 578101 cttttcagca gggcgccatt tcaccagtga cttggctgat gctatctgaa attttcccgc 578161 ttcgccttcg cggactggga atgggtgtta cggtattctg tctgtggatg gtgaattttg 578221 cagtcagttt cacgtttccg atattgctgg cagctatcgg gctgtccaca acgttcttta 578281 tcttcgttgg attaggaatt tgctctgtct tgtttgtgaa gaggtttttg ccggaaacga 578341 aagggctttc gcttgagcag ctggaggaaa acttccgcgc ttatgatcac agcggggcaa 578401 agaaggattc tggggctgaa gtgattggat aatttaaaaa agaatccgca cccgagtgcg 578461 gattcttttt ggtttcaaat tagttaggtc taacaaggat tttgacttgg cttttctctt 578521 taataagagc cccgaagcct tcctcgatca aatcatctag tacgattttt ttcgttacga 578581 gtttgtcggc tgagaaatag ccttctttca ttaatgacaa tacagccggg aagatgtcgc 578641 ggtatccgat aattcctttt actgtacgtt ctttgattac gatatcgttc ggatggattt 578701 cagcaccttt ttcccaaatg ctgacgatga cggtttcacc ggcaattgta gtggactgga 578761 tggcttgtcg taacaccact gggacaccag tgacttcgaa tgctacgtca acaccgcctc 578821 ctgtacgttc tgcaatctca gcgactacat cgtctgtttt agacggatca acgatgatcg 578881 cgccaagctc ctcagctttt tgctggcgtt caggagaaag ctcaacagcg taaatatcag 578941 ttgcaccggc agccttcagc gcttcaatga caagaagtcc gatcgggccg cagccgaata 579001 cagccgcttt gtcgcctgct ttgagtttgc ttgagcggac agcgtataga gcaactgcag 579061 aaggttcaac gagcgcgcct tgttcatatg ataattcatc aggaagtttg aacaaaagct 579121 cttcatccac agagacgtat tcagagaaac cgccgcctcc gccggctaag ccgaggaatc 579181 ccatttgttc atcaaggttg taggcgcctt ggtggccgtg tgtagcaaaa atcggctcga 579241 ctacaacgcg gtctccaact ttataatttt caacgccttc tccgacttcg acaacttcac 579301 cggagaattc atgccccatt gtgacaggtg ccgtttcatt tgttaatggg tgcggtttgt 579361 caaccggaat aaagatcggg ccgcccagat attcgtgtaa atcacttccg cagatgccgc 579421 accatttgac tttgatcttt acttttcccg gctccgtttt tggctcttcg atatgttcaa 579481 tacggatatc cttttggtta tgccatcttg ctgccttcat ggattaccac tcctataact 579541 tttgatgtga gtaattccgc accggtcaat atgaactgtt cacaaaatcg ccatttttaa 579601 aaccaaaaaa gaaatgaaat ttttatataa tataatctac gtttttttga aaaaaagaaa 579661 ctttaaagaa aaaagggtct cgcacactct tttttcttta tatgagagta tcaatcgttt 579721 acatagctat gaatttggtt tgaacaatac ggtaatggtt cgttcatatt gaatgcgaca 579781 actactctat caataattat aactctaata ctgctattat aataggataa tcttccatgg 579841 tttattttag cagaggtaac ttttttgact ttgtaacatt actgtaagga tattgaaata 579901 aaaaatagct ggttgatcgt gtataatctt cctagatgtt aacaaacagg gggacgaaat 579961 gttgaagaaa gtcattttag ccgcttttat cttagtagga agtactttgg gagcttttag 580021 tttttcatca gatgccagtg cgaaacatgt gaacggaaat attacttggt ataatggagt 580081 cgggaaaaaa ggctcttcag gtaagaaact tggacattgg gattgtgcga ccaaaatcgg 580141 atttgatgtt cctagaaacg ggacaaaaat cagagcttat gcaaaagcga agcctaaaaa 580201 ggtgattacg gtttataaaa atgatgttgg cagaatgcct aatgcagtgc tggatgttag 580261 ccctaaagcg tttaaagcgc ttggataccc attaagcaaa ggtaaagtag cggggcatta 580321 cagctattaa tgtacatata taatctggaa agcaagaagt cacattcttg ctttttctat 580381 tggtggagat aaaagatgaa aaaaagaatc atattattat tagcagtgat aatagcggca 580441 gctgccgcgg gggttgcgtt ttatgttgca aaggataaag gccatgagaa ggctgctgat 580501 gtttcagtca ataccgaaag cggtgatgag ctgctggttt caattacaga tacggatctg 580561 ctgacaaagt attatgaaaa tgacaaggtg atccatgagg agaagctgac cagctatccg 580621 gcatttgcct tggatcaaaa acagcaggtg ctctattata cgggcaataa tgaacagaat 580681 gaaatgaggc tttttaaatt ggatctgaag tctcataaaa aaacgatgct ttataaaggc 580741 gcggagagtg cggacagttt atttttatca aaggaccgtt caaccatcta tttccgctta 580801 ggaaaagcgg acgaaagcaa ttttcgaatc gccgcttttg atctgaagac gaaaaagtat 580861 aaaaatcttt atcctgccgc taatgatcag gatgacaccg tcagcagctt cttttataac 580921 caaaaaaacg attcatttgc attgcttcat tattctgtag aagaagacta caagaaaaca 580981 gatgaagcaa acgaaaaggg catcgaccct gaaccgacaa cgattcattt tgcggaaggc 581041 cgccaaaata aatttaatga gctgaaaagc ctgaaccaat ttatcagcga tattgctgtt 581101 tctgatgatg ataaacgtat tttattcaca tcatatacgc aaaaaggaac ggagcaaacc 581161 gcttctattc aaatgctcaa tgcggatacg aaaaaatatg aaagcatcat ctcaaatcaa 581221 aaatcattta agctgttaat tgacgcacag cctcagtttt ctaaggatgg gaagaacatt 581281 tattttcttg ccgaagccaa gggggctaaa aagctgaagg acgaaacagg gcgtgaagct 581341 aaggtgcgga cgatttattc ctatagcctt gagaataaga ccttcaaaaa agtatgggaa 581401 aatccgaacg gcatcatcaa cagctttttt gtgattaact aataaaaacc actcggcatg 581461 agctgagtgg cttttttaat ggatgaggtg cagggctaat gatccgagcc atttaaagat 581521 atgaatcaga ggtaccgaca aaaacagaag ttcaacatat gagttcattg caacattcag 581581 ctttttgaac gcagctcttt ttttcaagtc tttttgctgc tggtttgaga tcacgttatc 581641 actcctctta tatccatatt ataccattaa aacagacaaa aaagccctaa acgtttacag 581701 ttttgggctt ctttcttcgt atttggcctc ttgcaatgag aggcttttat tctgaaatat 581761 agaattttgt ctccgttcgg ggtttgtttg cttgcgggag actgcatttg ttatagggaa 581821 gaactagctt gttttcgttt ggctgttgtt ttggagattc actaatgaac ggatgccgtc 581881 gaccatttta cttccgcaca aagggcacaa tggcgtatca ctgctggcga agttttttcg 581941 ggtccagcca ttacagtctt cttttgtgca ttcccaagta ctcacatctt cctttggcag 582001 cggttcttga tttcgtttgt tatagtaaga cataaagtca cttcttccct catgtatttt 582061 actgcacatt tcctattgtc tcatactttt ccctaatctc ctaattcctt tttctttatg 582121 actttccaat aaccccatct aaaaaggaga ggagtgtgct gttaaaagca tctggctctt 582181 ctaaaaacgg gcaatggctg cttttaggaa aggtaacgag tgtcgcgttt ggaatattgc 582241 tgcgcaagtg ttccccagct gctgtagaga aaaatttctt gtcttccccg aagcacagca 582301 atgccggcac attgatgttt tggagggtgc cccggtaatc agcggccgtt tggttaaata 582361 aaatcgtgct agaaatggca gccggctgtt tgaggatttc tgccagcatc cattctgttt 582421 cggtctcggc aggcggttct gcgaacatat tctggatgaa gctttcgtag aaaggcagcg 582481 ggtcagtttg aatggcgtgc atcgctgttt ttaagccgtc aaaatcaaat ggaccatgtt 582541 cccagccctc ccattgatag tccgaagcgg attgatcgat gatcacagcg gcttgaatgt 582601 tatcattccc aaactgattg agataatccc atacgacaaa agcacccatt gaccagccgg 582661 caagaacgac atgatcaagc tccattgcat ttagaaattc ccttatgtca cgggcatatt 582721 gggaaatggt gtggccgtga agcactttgt cagattcgcc gtgtcctcta agatcaagac 582781 gaatacattg ataattggca gaaagcaccg aaaattgttt gtggaaaaat tgtccgctca 582841 tcagcacccc atgtataaac aggatcggcg tcccgctccc gtgtgtttca tagtaaaggc 582901 gtgtctgatc ttctaatatg atgtatggca tgtttctcct cctttagttt ccatcatgag 582961 tatggctggc tgctgttgag ctgatgatgg cagctgtcgc ggctgcctgc tgcgcttgaa 583021 tgactgtttc gatagcggtg tatagtcctg attccatcag cagatttttc tccatatgct 583081 cactgagata gaggctgaca gcaattttaa agttcatttc cttttgccat ttaaaagctt 583141 tttcctggtt taattcgtca gtgatgcaca aaacggtttt gatatctggc tcttccagaa 583201 atgtgaggag agcaaggtct ggataatgat aatcctttgt ttttttgaca gattcagtga 583261 tcgattgata tatctgtttg caagcggaaa caagcatttc gggctctttt tcactttgca 583321 aggccagaat atggctgacc tgatgtaagt actgtccttt tttaaagccg ttggctgcca 583381 gcagttgata gcatgtttcc gccttctgta gcgcctgcaa accttttccg ttttctccaa 583441 gcagtacggc aagcggaaca ttctgagttg aagtgaggaa ataatgattt ttcttcatct 583501 gctgataaac agctagcccc atgttcatct gttctttttg gtttgtcgtt tcagatttgc 583561 cggtgagcaa gatcagagcg gaaaggtatg tgaacatatc ccgcttatac cctagcttca 583621 ccatttcatt gtatacatcg atgaaagtct gaaatgtttg ttttgcctca tgctgaaaat 583681 gaatgtccag aatagatgca acagtaaagc ggtggtgtga attgagtgtt gagaagctgc 583741 cgatgtttga tttgatatag ctgctcaaat cataaaagcg ctgaaaatca aactctcttt 583801 tattcacaat atatgcagaa gaaatgagca ttaatatctg atcgtgtgaa actttccatt 583861 ttaattttgt ttttaattca gcataaatgg aaatgtaatg ctttgttttt tcatgtagat 583921 cgtgtgtgag cataaaaagc agctcctttt gttgttttta cgtaatacga taaatagggc 583981 caaaggtttc ataaagaaaa aacttgcctg ctagaggcaa gtttgtcggg ttatttatgg 584041 ggatcagtta tatccatcgg tctcatcatg tcatagtctt catgctctag aatatggcaa 584101 tgccatacgt atcgtccgct gtacggaccg aatgtcgccg cgattctcag gacttcacct 584161 gcatgcgctt gaatggtgtc tttccagccc ttttcacttg gcggcggcgg gacagccgga 584221 ccggtatagg acaattcccc gctttcttga taacgggcga tatcaaacgg ccgccggtct 584281 aatacacgga aggagactag atgcaggtgg atcggatgtg ttccgcgtgt cgggttgata 584341 atggaccata tttcagttgt gccgactttt ggtgtttctg tgacgggatc gtgccagcgt 584401 ttgttattaa gcagaaggac gggtctgccg tattcgtcct gggtgcctgc cagttttaac 584461 gttctgatgt tttgtattct ttcatgctgt accgaagggt atgaggcgag gtacttcggc 584521 tttctgcttt cgtctttttg tgccaatggt tttgtgactc tgaattgcat gatattcgca 584581 tctgtttcag gattgacgtc accgccgcag cccgcgctgt ttgccaaaat gatcgattct 584641 ccttcatatg ctgtgaagtc aatgatgata tcgtaacgtt cagcaggcgc aaggctgaaa 584701 gaattcagtt taacagatcg cggcaggagc cctccatctg aaccaatctg aataaaatct 584761 ccgccattat cgagtgacag gttataggtt cttgtattgg aggcgttgat gacacggaat 584821 cggtatttcc ttggctcgac ttccaagtat ggccatacct tcccgttgac gagtatggtt 584881 tctccgcaaa aagccggaac gattgaagga ttaggcagtg acggagaagg gttttccggt 584941 gcgctcggat aaaacaaaga accatcctca ttgatcgtgc ggtctgtgat aagaagcggc 585001 acatcgtatt cgtctgaagg cagttttaag cgtttttcct ttgggtcatg aatgatatat 585061 gcaccgacaa gtccggcata gacatttagc ctggtgagcg ccatggcgtg atcgtgatac 585121 cacaatatag ccccgcgctg ctggtttgga taatgataaa cctctctttt gaaataaggt 585181 cctgtttgtt caaagtcttt ggaaaaccaa gcctccggat acccgtcact atcatctggc 585241 gtgacgccgc cgtgtaaatg aacaacagtc tttacctcgg gctcttcatg ctggctgtca 585301 ctgtgatgaa tggtgtgatc aatcggaagg aaatgcgtgg aaggaaggtt attcatccat 585361 tttacatata cgttttcatt tcttttaacc tcaatggtcg gtcccggaaa taagccgttg 585421 tagccccaca ggcgggttgg agggagatcg cgatggagct gatgagtgca ttcctccatg 585481 gtgacttcgt agtatgtttt ttcttttgat tgctgtactg gctttagtgt atctgggatt 585541 gggagagcat ccacaaattt ttcaagtgtc attttcatct gtccttatct aaattttcca 585601 aattggtact atagttaatg acaataagga cgtgatggtt acaaaaaatc ttcgtgctgc 585661 agcccgcccg aagaagaaaa taacaaaatc ctaaacggca ggccgtttag gatttgatca 585721 gcattaaggc aggatatcgg gttgctgctg tgtgactggg ttggcagccg ctttctcgct 585781 caccttgcgt tttctgaaca caaggtaaga aatcagaacg attcccgtga tgacgcctgt 585841 cagcagcagc tcgtctctca tggaatcaat aaacgccatg gacactaaaa ttccgcaaat 585901 ggcgatgatg gtcaagtagg ttaggaaagg gaagagccac attttgatct tcaatgcttc 585961 tgggtttgtt ttttcgagtt ttttccgcat tttcagctgg gaaacggcga tgacaagata 586021 gacgagtaaa gcgattgcgc ctgatgagtt gactaagaat aaaaagacgg tatccggtga 586081 aaaatagttc attacgaccg cgatataaga gaaaaatgtc ccggccacaa tggcttgtac 586141 gggaacgcct tttttgctca atttcataaa acggcgcggc gcttcatttc tttctgcaag 586201 tgaatacagc attctggatg tggtatacaa acctgaattc aggcaagaga gtacggctgt 586261 gaggacgata aagttcataa tctgtgcggc tgcgggcact cctatatgct caagtacagc 586321 gacgaaaggg ctttctaaaa tatttgctga attccatggc aacagcgcca cgacaatggc 586381 gattgagccc acgtaaaaga cgatgatgcg ccatacaacg gatctggtgg cttttgtcac 586441 agattcgatc gggttggatg tttcccctgc tgcaatggca acgatttcag ttcccataaa 586501 agagaagatg acaacgacaa tgccgagcaa tacggagctg atgccctccg ggaaaaatcc 586561 gcctttgcct gtaagattcg aaaaaccgac tggctcactg cccggtgcaa agccaaaaat 586621 aaaggcaaaa ccaacgatta gaaaagcaat gatagtcaca actttaatga gggagaacca 586681 atattcaaac tcaccgaaag acttaacgga gtagacgttt gtcagggtga gcacaatggt 586741 caagatcaaa cttgtcagcc acagcggaat atcatggaac cagtattgaa taatgccagc 586801 accggcaatg gcttcgatcg ctatgacgat cacccagaaa aaccagtaca gccagccgat 586861 tgtaaatcct gcccacggtc cgatggcgtc gtgagcgtat tgagaaaacg atccgctcgt 586921 cgggtttacg gcagacatct caccgagcat tctcataata aaaatcacca ataatccggc 586981 taacgcgtaa gaaacaacgg cacccggacc ggtcgagtga atcactgaac cgctgcctac 587041 aaataggccg gctccgatta caccggcaat cgaaatcatt gtcatatggc gggtctttaa 587101 ttcctttttt aatcctgatt gagactggtt cataagttac ctccttttaa aatgcaatca 587161 ttactgaata ttatgataat tgaaactcta tcataaatat acagtttgtc gaaaattcgt 587221 gtaagaaaat ataccagctt atttcaaatt tgtagtgttt tgtttgcgct ttcagcgaat 587281 gtgtggaaaa aatgtttcgt tttttattcg ctgtgtgatt ttgcgtaata tttacaattc 587341 gatagaatgc gagaagcact ggtgtccttg ggtttgatgg gatttttggc ggagcaaata 587401 aattggatga gagaaaaagt gttccttcgt cactattttt ctgtggcggg tgaatcatgt 587461 ttctgtagac ccactgcgga tcagctttgt aagataataa taggaaaatg tgagcgagag 587521 gaggttttgt atggagagat atgatgaact gaaaaaggga gaatccggag cgctggtcag 587581 cattgccgcg tatctagttc tttccgcaat taaactgatc atcggttatc tttttcactc 587641 ggaagcactt acggcagacg ggttaaataa cacaactgac attattgctt ctgttgctgt 587701 gctgattggc ctgcgcatct ctcaaaagcc tcctgacgaa gatcatccat acggccactt 587761 tcgagcggaa acgattgcat cgcttatcgc atcgtttatt atgatggttg tcggactgca 587821 agtgctgttc agcgccggag aatctatttt ttctgctaaa caagagacgc cagatatgat 587881 tgcggcttgg acggcagcgg gcggggcagt cctgatgctg atcgtttacc ggtacaataa 587941 aaggctggcc aaaaaggtga agagccaggc gctccttgct gcggctgctg ataataaatc 588001 agacgcattc gtcagtatcg gcacatttat cggcattgtg gctgctcaat tccatcttgc 588061 ttggattgat acggtcactg cgtttgtgat cggtctgctt atttgcaaga ccgcatggga 588121 tatctttaaa gagtcatctc actctttgac agatggattc gacataaagg acatttccgc 588181 ttataaacag acaatcgaaa aaatctccgg tgtgagccgt ttaaaagaca taaaagcaag 588241 atacttgggc agtacggttc atgttgatgt ggtggttgag gtatcggcag atttaaatat 588301 tacggaaagc cacgatatag ccaatgaaat tgagcggaga atgaaggagg agcatgcgat 588361 tgattattcg catgttcata tggagccttt agaacaaaaa taatggagct tcctgtcaca 588421 ggaagcttca gcgtgtcgac aaaccctcgc attcgttgtc aggtctgcgc ttcggtgctc 588481 acgaattaga acattcgctc cgctcctatg ctcgtccttc ctagacttca agggttttca 588541 atcacgctga aaagatgaca aaaccctaaa atgaaagcca ttttaggatt ttgtcaacaa 588601 tctggagctt cctgccacag gaagcttttt tgtgtgtttt ggccagcttt attggtaaca 588661 atttgctaga atcgtttttt tatacagatt gctttttgtg gtaaagttag gttacattat 588721 gatgaatttt gtagatgact aggaggaaaa taatggcata tcaagaagac ctgcatcctt 588781 tgctggggaa agcagttgaa catattaata gagtaatggt tggaaaacga gacatcgcca 588841 tactcagctt agcagccctt cttgccaaag ggcatgtgct gcttgaggat gtacccggag 588901 tcggaaaaac gatgatggtc cgcgcgctgg caaagtcaat cggcgccgat ttcaaaagaa 588961 tccaattcac tccggatttg ctgccatctg atgtaacagg ggtatctatc tataatgcga 589021 aaacgatgga atttgaatat cgtcccggcc caattatggg aaatatcgtg ctggcagatg 589081 aaatcaaccg tacctctccg aagacacagt cggctttgct cgaagcgatg gaagagggga 589141 gcgtcacggt agatggccat acgatgcagc ttgccgatcc gttttttgtg atggcaacgc 589201 aaaacccggt cgaatatgaa gggacctatc ctttgccgga agctcagctt gaccgttttt 589261 tattcaaact tcggatgggt tatccgtcct ttaatgaaga gcttgacgtc ttatctcttc 589321 aggaaaaaag ccatccgatt gagacgcttg agccggttat tgcaaaagaa gacttcatct 589381 ttttacagag ggaagtgcaa aatgtccgtg ctgatgacag cattaaggaa tatatcgttg 589441 aaattgtgca gaaaacgaga cagcatcctt ctgttcaatt aggcgtcagt ccgcgcggct 589501 caatcgccct catgaaagcg gcacaggcat acgcgctgct gcatcatcgc gactatgtca 589561 taccggatga tattcaatat ttagctcctt tcacgctgcc gcaccggatg atgcttcatc 589621 ctgaggcaaa atttgaaggg attcaggcag aagcgatcgt aagggagatc atgtcagctg 589681 tgaaggtgcc ggttcaaagg tcggcggtcc gctgatgaat aagaaatggc aatggctcgt 589741 atatggttgg aagctgatta tattaacttt attgacggct gctgtttttt cttatgcgat 589801 gtttcagggc ggctttgtca gctggttttt gttttacgcg tttctccctt ttgtcttgta 589861 tgccgggctg ttggccttgt atccgctccg ttcttttcag gcttcaaggc aaatggataa 589921 aacacaattg catgcggggg acaggctggg cgtaacggtt acgctgagaa gaaagctgcc 589981 atttccgctg atgtatatgg tgattgaaga ttgcctgcca gaaggtatcg agtcattaaa 590041 tcgagacgga gccgcggcca aacggctcgt ttttccttgg tttaaacgga gcatgacgat 590101 gtcgtatgaa ttagctcggg taccgcgcgg agagcatcac tttcattctg tcagggtgcg 590161 aaccggggat gttcttggct tgattgaaaa aacagcattt tttgagctgg atgatacctt 590221 gtttgtttat ccattctatc agcgtttttc ctatcaggtg aatgagaggc atcaggaaga 590281 cggtgtaagc ggttcttctc ctattcatca gcaccattcc tcagtcgcag caagtgtgcg 590341 gaattatcag ccgggagacc ggtttgctgc gttagattgg aagacatctg cacggcggag 590401 ccagctgatg acgaaggaat ttgagccttc tcgcagcaaa aatctgtttc tgctgatgga 590461 ccgtttttcc tcagacgcat tcgaagaggt cgtttcagtg acagcttcga ttcttcattc 590521 tgttttaaaa aacggcgcgg gtgctggtct ggcttccatc gggaaggaaa aaaacatttt 590581 ccctattcag gaaggggatc agcattttaa gcacatgctt cggcatttag ccatcgctca 590641 ttgtgatgcg gcagacccga taagccgata tgcacgggaa gagctgggaa agccatctgt 590701 tcgccaagct gatcaagttg ttgtcacggg acagttaacg gaagatatgc tgcacctcgc 590761 agaaatagga ggcggccggg ttacggtgat actggcaaaa gagaaagatg ctgagctctc 590821 tcaagctgaa aatgtcatga ttgaacgcat gatgaaacgc caaatcagag ttcggatcat 590881 gaggggcggg cgagtttcgc gtgttgttta gaaagagagg tgactggttc acatgccgca 590941 cgatgatcac aagggaagcc gtttgagctt gctgttattt tattttctgg cttttttatt 591001 gctgtgggag tggcttaggc cgcttgacag ttttactgaa acgaaacata caggcttttt 591061 tagtgtcttt atcggcttga cgtttctgct gacttttttc aggatgaggt ggtttgtcac 591121 cgttcctttt tgtgtcatat ttacattgat ctcgatacac atcctgtttt atcaaggatc 591181 tatattcgac ttgagctggg tcagctcttt tttgcaggat gtctatctga atatcacgct 591241 gattcaatca gggcaatgga atgacatgat tccttcattt cggaccctgc tgttttttgt 591301 gctgctgtgg ctgctggtct atctcctgca ttattgggtg atttaccaga gaagaatttt 591361 gtttttcttt ttgatgacag tagcgtatat tacgattctt gataccttta cgccatatga 591421 tgccactttt gccgtaatcc gtatcgtgct gatcggcttc tttatgctgg gccttttata 591481 cttggaacgc attaagctga tggaaagaat cacactgcca aaaacatctg tcctgaaatg 591541 gtttcttcct ttatctgtat tggttttggc tgcaacggga ttcggactcg ccgctccaaa 591601 atcagagccg gcttggcctg atccggtgcc ttttcttaaa aaaatcactc atcaagaccg 591661 cgtgtctgca ggggaaagca aaatcggata cgggaatcat gatgaatcac tcggcggccc 591721 gttccagcag gatgctacac ctgtttttac atggcaggga aaagagcgta cgtatttccg 591781 tgtggaaacg aaggacacgt ataccggaaa aggctggatt gaaacagaca caggcatgtc 591841 gtatcagctt agcaatggaa aagttgaaaa tctgtggttt gaccataagg ttgcgacaga 591901 gcgccgcacc gtccgtgtaa aagtcgataa gcactacggg tataaccatc tgatgtatcc 591961 gattggtgcg gaaaccattc agccaaagca ggctgtctca cttgaaatga acggcaacac 592021 ggagcaaatt tctccgatca gtgaacaagc cggtgaaatc agaaatatgg ggaattatac 592081 agtaacgtac aattccccgg tctataagct ggatgaactg agaaaggtaa aagtgagaaa 592141 aaacagtgag gagtacacat tcagcgatcg ctacatgcag cttccagatt cactgccaga 592201 gcgggtgaga acccttgcga tcaaactgac tcaggatcac gacaatatgt ttgataaggt 592261 gaaagcggtt gaggactatt tagggtcaaa tgcgttcaca tatgaaacag aaaacgtgac 592321 cattccgaag aatgatgaag attatgtcga tcaatttctc tttgaaacga aaatgggtta 592381 ttgtgataac ttttcttccg ccatggtggt gctcttgcgc tcggccggca ttccggcccg 592441 ctgggtaaag ggttatacgt ccggcgaata caaagaagca gggaacaaaa atggcagcat 592501 ttacgaagtg acaaataaca atgcccattc ctgggtagag gtgtatttcc cggaacaggg 592561 ctgggttaca tttgagccga ctaaagggtt tacaaatccg gctcaattta catcttctga 592621 cacaaaagac tctggcagcg atagcagcag ctcgccgaag aaagcaaaag agaaacagaa 592681 agaagagaaa aaacagccgc aaaaagagga aaaacaaaag gaaaagcggg agccagctgt 592741 ttctaaaaag ccgtccgctt cgcatactaa tgccggtgcg ggcttgtatg cagcgcttgc 592801 ggttcttgca gtcctcctgg tggcagctgt attgctgtat gttttccgct cgttatggat 592861 tcctgttttc gccgtgagga aattgaagcg gcgcagtgat cagcacgcgt tttttgaggc 592921 atatggcgcg ctgctgaaac aactgaagag aaaaggactg ccgaaacgag acagtgaaac 592981 gctgcgtgat tatgcaaaac gaattgatga aaaatacgac atagaagaca tgtcaaagct 593041 gacattaagc tatgaaaggg cgctttacag aaatgaagat tcttcggcgc tatggaatga 593101 ttcgagagag ttatgggaaa atttaattaa aagaagatgg tcttgaccgc ttatcgacgt 593161 gttgttagaa ttagtgaata ttatcggagt ctgggagcga gttggcctga ctccggcaaa 593221 cggccttgcc aaagagggcg gagcgagctt catatctgtc ctcgtttttt tctgtgtcaa 593281 aaaacttaga ggagattagg tgacaaccat gacaaagtta gtgaatgaaa tgattcttgt 593341 ccttgatttc ggcagtcagt ataaccagct gattacacgc cgtatccgtg aattcggtgt 593401 ttacagcgag ctgcatccac atacattgac ggctgaagaa attaaaaaaa tgaatccaaa 593461 aggaattatt ttatccggcg gtccaaacag tgtgtatgat gaaaactctt tccgctgtga 593521 cgagaaaatc ttcgagcttg atattcctgt tttgggaatt tgctacggca tgcagctgat 593581 gactcattac cttggcggta aagttgaagc ggcaagccag cgtgaatacg gaaaagcaaa 593641 catccgcatc gaaggcacac ctgatttgtt cagagatctt ccgaatgaac aagtggtttg 593701 gatgagccac ggcgatttgg ttgtagaagt tcctgaaggc ttcactgttg acgcgacaag 593761 ccatcactgc ccgaactcag caatgagcaa agcggacaaa aaatggtatg gcgttcagtt 593821 ccacccggaa gtgcgccact ctgaatacgg caatgatctt ctgaaaaact ttgtattcgg 593881 tgtttgcgaa tgcgaaggcg aatggtcaat ggagaacttt atcgaaatcg aaatgcaaaa 593941 aatccgtgaa acggtcggag acaaacaggt tctttgcgcg ctaagcggcg gcgttgattc 594001 ctctgttgtt gctgttttga ttcataaagc gatcggcgac cagctgactt gtatctttgt 594061 agaccatggt cttctccgta aaggcgaagc tgagggtgtt atgaaaacat tcagcgaagg 594121 ctttaacatg aatgtgatta aagtagacgc aaaagatcga ttcttaaaca aactaaaagg 594181 cgtttctgat cctgagcaaa aacgcaaaat catcggtaat gaattcattt acgtgtttga 594241 tgatgaagcg gacaagctca aaggcatcga ctaccttgca caaggtacgc tttacacaga 594301 tatcatcgag agcggtacag caacggcgca aacgatcaaa tctcaccaca atgtcggcgg 594361 acttcctgaa gacatgcagt ttgagctgat cgagccgtta aatacgctct tcaaagacga 594421 agtgcgcgcg cttggcacag agctcggcat tccggatgaa atcgtatggc gtcagccgtt 594481 cccaggaccg ggactcggaa tccgcgttct tggcgaagta acagaagaaa aacttgaaat 594541 cgttcgtgaa tcagatgcaa tcttgcgtga agaaattgca aatcacggct tagagcgtga 594601 tatctggcaa tacttcactg ttcttcctga catccgcagc gttggtgtta tgggtgacgc 594661 aagaacatat gattacacaa tcggaatccg cgccgttaca tcaatcgacg gcatgacatc 594721 tgactgggcg cgtatcccgt gggatgtgct tgaagtcatt tcgacacgta tcgtaaacga 594781 agtgaagcac attaaccgcg tggtgtatga tattacaagt aagccgcctg cgacgattga 594841 gtgggaataa gaatcaatta atggaaacca tctttttggc aattttgccg ggaagatggt 594901 tttatttgtt tattacgaac aaaatccgat tttgcgcgac tattgttcgc tttttgtatt 594961 gttttttcaa aatgaacttg gtacaataga cacagaaatc aaataagatg aattcgtata 595021 atcgcgggaa tatggctcgc aagtctctac caagctaccg taaatggctt gactacgtaa 595081 acatttcttt cgtttgatat aaataaaaca cggttattta ttcaaactga aatccgtctg 595141 tagtcaagcg tcccaaaatg tattgggacg ttttttattt ggcgttttca ggacagaata 595201 aatagcaaag agtgaaggga gtcaaatagc ttgaaaacgt tttttcagtt tgatgagctg 595261 ggcaccagct atcgcaatga aatcattggc ggattaacga cttttttatc tatggcatat 595321 attttgttcg tcaatccgat tacgcttgct ttggagagcg tgaaagattt tccggaggcg 595381 ctgagaattg accagggtgc ggtctttacg gcgacagcgc tggcgtctgc agcaggctgt 595441 atcttaatgg gattaatagc gagatatccg attgccatcg cgccgggtat ggggctgaac 595501 gcgttttttg cgttttctgt tgtccttggt atgggtattt catggcaggc agctttgtcc 595561 ggtgttttta tttcaggtct tattttcgtt gctctttctt taacaggttt tcgtgaaaaa 595621 atcatcaacg ccattccgcc tgagctgaaa ttggcagtcg gtgcggggat cggcctgttt 595681 attacatttg ttggattaca aggttcagga atcattacag cgaatccttc tacgctcgtc 595741 acgatcggaa acattcacag cggtcctgtg ctgttaacga ttttcggtgt gattgtcacg 595801 gttattttaa tggtgcttcg cgtgaacgca ggcgtgttta tcgggatgct attaacagcg 595861 gtagccggca tgattttcgg tttggttccg gttccgactc aaattatcgg cagtgtgcca 595921 agccttgcgc cgactttcgg acaagcgtgg attcacctcc cggatatttt ctctgtacaa 595981 atgctgatcg ttattttaac attcttgttt gtcggatttt ttgatacagc tggtacactt 596041 gttgctgtgg caacacaagc tggtttaatg aaggaaaaca aattgccgcg tgcgggccgt 596101 gcgcttttag ctgattcatc ttctattgtg atcggtgccg tgcttggtac gtctacaaca 596161 acttcttacg tggaatcaag ctcaggtgtc gctgcgggtg cccggtcagg atttgccgca 596221 attgtaacag ggattctctt tttactggct acgtttttct cgccgctcct atcagtcgtt 596281 acgtcaaatg taacagcgcc ggcgcttatt attgttggtg cattgatggt ggcgccgctt 596341 ggcaaaatcg cttgggataa gttcgaagtg gccgttcctg ctttccttac catgatcatg 596401 atgccgttaa cgtacagcat cgcgactggt attgccatcg gatttatttt ctatccgatt 596461 acaatggtgt gcaaaggaaa agcaaaagag gttcatccaa tcatgtacgg gctgtttgtc 596521 gtatttatcc tgtactttat cttcttaaaa taaggaatga aaaaccagct gcactggcag 596581 ctggtttttt tgttgcaaaa gataaaacca tttcatacga tataccgtca tgtagatgtg 596641 ccgccatgct ttacttaaat ggaaatgact tgactgttca ggaaggcttc ggtaccttat 596701 ataagtgttt tattttcttg ctgaatggta ttccgccgta tttttttgat aggagttgct 596761 gacatgacgg aagaaagaaa agaaacgttt gaagaagaaa ttaaccagag tgaaagaata 596821 gatgcagatg aagaaccgct atcgagaatg tccagaaagg cgagccggca aagcaagcag 596881 aagcaaaaac aaaagcagaa accgcgccag gaacgcggtg aatcaactgt taaagacaag 596941 cttgcgtctg tttgggcagc catcaacaga tattgcggtt ttgcgttctc gattttaaaa 597001 tctccggcga aaactgtcgt aacggatggt ttttctcatt ataagtacgg tctgatttca 597061 atgcttatat tcagtatcat tttttcaatt gggaattggt ttcagttaaa ggcaagctgg 597121 aatcggccgc tcggtttcgg agaacgccat catgctttct atgacgggtt tttagttgtt 597181 cttgtgtatt tgctgatctt tttcgcggta atggtctttg ctatatgggc tgtctcccgc 597241 tatatgatga agcagaaggt gacgttcaga gaagcggctg ccgtattggg ttcattgctt 597301 gtacccgtaa ttgctgtttc aatcctttgg ctgatctttg cgatcgtaaa tatcccaatg 597361 ctgacagtac tgtttacggt gctgatcttg ttttccatct tttttatcat cgcgctgtat 597421 gtacagcgtg tgtaccaggc ggcacaagat gcaccaattg attatatcta ttgtgtattt 597481 gcagtagttg cgatagcgct gctgtttacg gcagtgactt ggccgtttat ttctgaatat 597541 attacggcgt cgttgattcc gctttaatga aaaaaccggc taatcctagc cggttttttt 597601 atgtcacact ttttacaaat atatctaaaa aacatagttg atttgtagga ttaacccgtg 597661 tatgatgggg aaaatgctga aaacgtccag cgcaaaaacc tttatgttta aggaggatga 597721 tggacatggc tgatgtactt cgccgagcaa ttaaccaaaa gaagcaattt ttaaaaacca 597781 aattactgct ctcggaattt tatcaaggaa gaggggaaca gcttgctgac tacacgctga 597841 gtgagcttga gaaagaatac aagtcccttc agaaaatgaa aaaagagatc tgacaataga 597901 tataaagagg tgagtctgct gaaaagcggg cttttttgtt ttgattttga aaaggcgaga 597961 aagagggtaa actactactg ttcaacacat aaaagcgtgt cgaaatattt tgcttaagct 598021 tacgggcgaa gctgattgta aacggctcat ttctctagta gaatatgaat gctttgtgca 598081 agctgaagag tagggggatg aataaaatga tgcaaaccat cttatcaaat gggatagcca 598141 tggttctcat aattctcatt attaatattg tctatgtgtc attttttacg ataagaatga 598201 ttttaacgct gaaaggacag cgttatttag cggccggcat cagtacgatt gaaatactgg 598261 tttatgtgac aggactgagt ctggtgctcg ataacttaga ccagattcaa aatgtgatcg 598321 cgtacgcgct cggttacggt cttggcgtaa ttgtcggcat gaaaatagaa gaaaaattgg 598381 cgcttggcta tattatggtc aatgtgatta cgaaggagct cgatcttgat cttccgaagc 598441 agctccgtga aaaaggctac ggcgtgacaa actgggtggc aggcgggctt gaaggcgacc 598501 gcacagccct tcagatcctg acgccgagaa gatatgaact ccagctatat gatacgatta 598561 aaacacttga ttcaaaagcc tttattattg cgtacgaacc aaaaacaatc cacggcggct 598621 tctgggtcaa agcggtgaag aagaggagaa ttaaagaata atggcaaagc cgaagaagaa 598681 aaagtttgaa gtgacagagc agcaaacgat tgatgcggtg cttcagcaaa tgaaagaaga 598741 aggatatctg cctgtaaggc gaatggaaga gcctattttt atggaaaaaa aggaaaatgg 598801 gtcaattcag atcgttccgt gcgggaaaaa aatcgtattt gaagggaaat tgatctaaaa 598861 cacgaacatt agtagaatga atttttgtat cgttcgataa tatcgttgac attatccatg 598921 tccgttgtta agataaacat gaaatcaaaa cacgacctca tataatcttg ggaatatggc 598981 ccataagttt ctacccggca accgtaaatt gccggactat gcaggaaagt gatcgataaa 599041 actgacatgg atatatcgca gaagcgaacg actgacgata catgtaccat gcccggtttg 599101 tattgcttcc tcataagtgc aatgcagagc gggtattttt tattttctga aaacaaaagc 599161 attagaaggt ggggaacaga atgcagccgc tagtaggaat catcatggga agcacttccg 599221 attgggagac aatgaaacac gcatgcgaca tacttgacga actcaatgtt ccgtacgaaa 599281 aaaaggtcgt ttccgctcac cggacgcctg atttcatgtt tgaatatgct gaaactgcta 599341 gagaaagagg catcaaggtg attattgccg gtgccggagg agcggcgcat ctgccaggga 599401 tgacggctgc gaaaacaaca ctgccagtca ttggagttcc ggttcagtcc aaggcgctga 599461 acggaatgga ttcacttctt tccatcgtcc aaatgcctgg aggcgtgcct gttgcgacaa 599521 catccatcgg caaagcgggt gctgtgaacg caggcctgtt agcggcgcaa attttgtcag 599581 catttgacga agaccttgcc cgtaagctgg atgagagaag agaaaataca aaacagacag 599641 tgttagaaag cagtgatcag cttgtctaaa caaatcatct atccgggagc tgtaatcggc 599701 attatcggcg gcggccagct tgggaaaatg atggctgtgt ccgccaaaca aatggggtat 599761 aaagtcgcgg tcgttgatcc ggtgaaagat tcgccgtgcg ggcaggttgc ggatgtcgaa 599821 attaccgctc attataatga ccgtgaagcg attcgaaaat tggctgaaat cagcgatatc 599881 atcacatatg agtttgaaaa catcgactat gatgcgctgc attggctaaa agatcatgcg 599941 tatctcccgc aaggaagtga gctgctgctt attacccaaa accgtgaaac agagaaaaaa 600001 gcaattcaat ccgcgggctg tgaagtcgca ccgtacagca tcgtcaaaac aaagaatgaa 600061 ttgaaacagg cagtacagga gctcaggctt ccggcagtgc tgaaaacatg ccgcggcggg 600121 tacgacggca aaggccaatt tgtgataaaa gaagaggcgc aaatggagca ggcagccgct 600181 ctgttagaac acggaacttg cattcttgaa agctgggttt cttttaaaat ggaactgtcg 600241 gtgatcgtcg ttagatcggt aaacggtgaa atttcaacat ttccgacagc tgaaaacatt 600301 caccacaaca atattctttt ccaaagcatc gtgcccgcac gggtagagaa agggattcag 600361 cagaaggctg ctgatctcgc agttaagctt gcagatgagc ttaaccttgt cggaccgctt 600421 gctgttgaga tgttcctgac agaggacgga gagcttttgg tcaatgaact ggcgccaaga 600481 ccgcacaatt cagggcatta tacgctggac ctttgcgaga cgagccagtt tgagcagcat 600541 atcagagcgg tatgcgggct tccgcttggg aagacagatt tgctgaagcc gggcatgatg 600601 gtgaatcttc tcggcgatga agtgaagctt gttgaggaag acccggagct tttaaaagag 600661 gcaaagctat atatatacgg aaaacatgaa atcaaaaaag gccgcaaaat ggggcatatt 600721 acatttatga agcagcctga agacgaatgg attcaggaga tcacaaataa atggatgaat 600781 agagacggag gacaagcaga atgatcgaac gttattcaag acctgaaatg tccgcgattt 600841 ggacggatga aaacagattt caagcatggt tagaggttga aattcttgcc tgtgaagcgt 600901 gggcggagct tggcgtcatt ccgaaagaag atgtaaaggt tatgcgcgaa aacgcgtcat 600961 ttgacatcaa ccgcatttta gaaatcgaaa aggacacgcg ccatgacgtt gtcgctttta 601021 cgcgcgctgt atccgaatca ctgggcgaag aaagaaaatg ggtgcattac ggcttaacgt 601081 caactgacgt tgttgatacg gctctttcct acttattaaa acaggcaaac gatattttgc 601141 tcaaggatct tgagagattt gttgacatta taaaagaaaa agcgaaagaa cataaataca 601201 cagtcatgat ggggcgcaca cacggcgtac acgctgagcc tacaacattc ggcttaaaac 601261 ttgcgctttg gcatgaagaa atgaaacgta atcttgagcg cttcaaacaa gcgaaagcag 601321 gcatcgaggt tggaaagatt tccggtgctg tcggcacata tgcgaacatt gatccatttg 601381 ttgaacaata tgtctgtgag aagctcggat tgaaagcagc accgatttcc actcaaaccc 601441 ttcagcgtga ccgccatgct gactatatgg caacacttgc tttgatcgcg acaagcatcg 601501 agaaattcgc tgtggaaatc cgcggactgc aaaagagtga aacacgtgaa gtagaggaat 601561 ttttcgcgaa agggcaaaag ggttcatctg caatgccgca taaacgaaat ccgattggct 601621 ctgaaaacat gacaggcatg gcgcgcgtga tccgcggcta catgatgaca gcttacgaaa 601681 atgttccatt atggcatgag cgcgatattt ctcattcttc agcagaacga attattcttc 601741 cggatgcgac aattgcgctg aactacatgc tgaaccgctt ctccaacatc gtgaagaact 601801 taacggtctt cccggaaaac atgaagcgca acatggaccg cactctcggc cttatctatt 601861 ctcagcgtgt gctccttgct ttgattgaca caggcctgac tcgtgaagaa gcctatgata 601921 cagttcagcc gaaagcaatg gaagcgtggg aaaaacaagt gccgttccgc gagcttgtgg 601981 aagcggaaga gaaaatcacg tcacgtcttt ctccagaaaa aattgctgac tgctttgatt 602041 acaattacca tctgaaaaat gttgatctga tctttgaacg tttaggttta gcatagaaga 602101 agcttttagc ggcttcttct aagccgccgc agtttgaaaa ttcccaacat tcgggttagg 602161 aggccttccg tgaatattgt gaagaatgaa cttttatacg aaggaaaagc aaaaaagatc 602221 tacaaaaccg atgacgaaaa cacgctgtat gtcgtgtata aagactccgc cactgccttt 602281 aacggcgaga aaaaagcaga aatcagcgga aaagggcgct taaataatga aatttcaagc 602341 ctcattttca aacaccttca tgctaagggc attaacaatc attttatcga gcgcatttcg 602401 gaaacggagc agctcattaa aaaggtaacg attgtgccgc ttgaagtcgt ggtaagaaat 602461 gttgtggcag gaagcatgtc caaacgtctc ggcattccag aaggcacgga gcttgagcag 602521 ccgattatcg agttttacta caaggatgac gcgctgggtg atccgctcat cacagaagat 602581 catatttggc ttttgaaggc ggcgactcct gagcaggtag aaaccattaa gtccattaca 602641 acaatagtaa atgaagagct tcaaagcatc ttcgacgatt gtcatgtcag attaatagat 602701 ttcaagcttg aattcggttt agatgcagaa gggcaagtgc ttttggcgga tgaaatatct 602761 cctgacacat gccgcttgtg ggataaagaa acgaacgaaa agctggacaa agatttattc 602821 agacgcaatc tgggaagctt aaccgacgca tacgaagaga ttttcaatag actgggaggc 602881 attcatcatg tataaagtaa aagtttatgt cagcttaaaa gaaagtgtac tagatccaca 602941 agggagcgct gtccagcatg ccttgcacag tatgacttac aacgaagttc aagatgtgcg 603001 catcgggaaa tacatggagc ttaccattga aaaatctgac cgtgatcttg acgtgctagt 603061 gaaagaaatg tgcgaaaaac ttcttgcgaa cacagtgatt gaagattata gatatgaggt 603121 tgaggaggta gtcgcacagt gaaatttgcg gtgattgtgt tacccggctc caactgtgat 603181 atcgatatgt atcatgctgt aaaggatgag ctcggccatg aagtggaata cgtctggcat 603241 gaggaaacaa gccttgacgg cttcgacggc gtgttaattc cgggaggatt ttcttacggc 603301 gattacttaa gatgcggcgc catcgcccga tttgcgaata ttatgccagc tgtcaaacaa 603361 gcagcggctg aaggaaaacc tgttcttggc gtctgtaacg gattccagat tttacaggag 603421 cttgggctgc tgccaggcgc aatgagacgc aacaaagatc tgaagttcat ttgccgtccg 603481 gttgaattga ttgttcagaa cgacgaaacc ttattcacag cttcctacga aaagggagaa 603541 tcgattacaa tcccggttgc ccatggtgaa gggaatttct actgtgatga cgagacgctt 603601 gctacattaa aggaaaacaa tcaaattgct ttcacatacg gctctaatat taatggaagt 603661 gtcagcgaca ttgccggtgt cgtgaatgag aaaggcaatg tattaggcat gatgcctcac 603721 cctgagcgcg cggtcgatga actgcttgga agcgccgacg gtcttaaatt gttccagtct 603781 atcgtgaaaa attggaggga aactcatgtc actactgctt gaaccaagta aagaacaaat 603841 aaaagaagag aaactgtatc agcaaatggg tgtcagtgat gatgagtttg cattgataga 603901 atccattctt ggaagattgc cgaactacac agaaatcgga attttttctg tcatgtggtc 603961 tgagcattgc agctataaaa actcaaagcc gattctgcgt aaattcccga caagcggcga 604021 gcgtgtgctg caggggccgg gggaaggcgc cggaatcgtt gatatcggtg ataaccaagc 604081 ggttgtgttc aaaattgaat cacataacca cccatcagct ctcgagcctt accaaggcgc 604141 tgcgactggc gtaggcggaa ttatccgtga tgtattctca atgggtgcac gcccaatcgc 604201 tgtattgaac tctcttcgat ttggtgaact gacttcaccc cgcgtgaagt acttgtttga 604261 agaagtagta gcgggtatcg ccggatacgg caactgtatc ggcatcccga cagtcggcgg 604321 agaagtgcag tttgacagca gctatgaagg aaatccgctc gtcaacgcaa tgtgcgtcgg 604381 tttaatcaac catgaagaca tcaaaaaagg ccaggcaaag ggtgtcggca acacagtaat 604441 gtacgtagga gcgaaaacag ggcgtgacgg catccacggc gctacgtttg cttctgaaga 604501 aatgtcagac tcgtctgaag aaaagcgttc tgctgtccaa gtcggcgatc cgtttatgga 604561 gaagcttttg cttgaagcat gtctggaagt catccaatgc gacgccttag tcggcattca 604621 ggatatggga gctgccggtt taacaagctc aagtgcagaa atggcaagta aagccggttc 604681 tggcattgaa atgaatcttg acctgattcc tcagcgcgaa acaggcatga ccgcgtatga 604741 aatgatgctt tctgaatcac aagaacggat gcttttggtt attgagcgcg gacgtgagca 604801 ggaaatcatc gatatttttg acaagtatga tcttgaagcg gtttctgtcg gacatgtgac 604861 agatgataaa atgcttcgcc tgacacataa aggagaggtt gtgtgcgagc tgcctgttga 604921 tgccttggca gaagaagcac cggtttacca taagccttct caagagcctg cttactatcg 604981 cgagtttttg gaaacagacg ttccggctcc gcaaattgaa gatgcgaatg aaatgctgaa 605041 ggcccttctt cagcagccga cgattgcgag taaagagtgg gtttatgatc agtatgacta 605101 catggtgcgc acgaatacag ttgtcgctcc tgggtctgat gctggtgttc tcagaatccg 605161 cggaacgaaa aaggcgctgg cgatgacgac agactgtaac gcgcgttatc tctatcttga 605221 tcctgaagtc ggagggaaaa ttgctgtcgc tgaagcagcg cgcaacatca tttgctcagg 605281 cgcagaaccg cttgcggtga cagataacct taacttcgga aaccctgaga agccggaaat 605341 cttctggcag atcgaaaaag cggcagacgg cataagcgaa gcgtgcaatg ttctcagcac 605401 tccggttatc ggcggtaacg tatcgcttta taacgaatca aacggcacgg cgatctatcc 605461 gacaccagtt atcggcatgg tcggcctaat tgaagataca gcgcacatta caacacagca 605521 tttcaaacaa gcaggagatc tcgtatacgt gatcggcgaa acaaaaccag agtttgccgg 605581 aagcgagctg caaaaaatga cagaaggccg tatttacggc aaagcgccgc aaatcgatct 605641 tgatgtagag ctgtctcgtc aaaaagcact gcttgacgcg attaaaaaag gcttcgttca 605701 atctgcgcat gatgtgtctg aaggcggctt aggcgtagcg attgcggaaa gtgtcatgac 605761 gacggaaaac cttggcgcta atgtgactgt agaaggggaa gcggcgttat tattctctga 605821 atctcaatct cgcttcgtcg tttcagtgaa aaaagaacat caagctgcgt ttgaagcaac 605881 tgtcaaagat gcagttcata ttggtgaggt aacagctgac ggaattctgg cgattcaaaa 605941 ccaagacgga caacaaatga ttcatgcgca aacgaaagag cttgaacgcg tatggaaagg 606001 agctatccca tgcttgctga aatcaaaggc ttaaatgaag aatgcggcgt ttttgggatt 606061 tggggacatg aagaagcccc gcaaatcacg tattacggtc tccacagcct tcagcaccga 606121 ggacaggagg gtgctggcat cgtagcgact gacggtgaaa agctgacggc tcacaaaggc 606181 caaggtctga tcactgaagt atttcaaaac ggcgaactca gcaaagtaaa gggaaaaggc 606241 gctatcgggc acgttcggta cgcaacggct ggaggcggcg gatacgaaaa tgttcagccg 606301 ctcctcttcc gttcccaaaa caacggcagc ctggcgcttg ctcataacgg aaatcttgtc 606361 aacgccactc agctgaagca gcagctcgaa aatcaaggga gcatctttca aacctcttcg 606421 gatacagagg ttttggctca cctgatcaaa agaagcggac acttcacgct gaaggatcaa 606481 attaaaaact cgctttctat gctgaaaggc gcctacgcgt tcctgatcat gaccgaaaca 606541 gaaatgattg tcgcacttga tccaaacggg ctgagaccgc tatccatcgg catgatgggc 606601 gacgcttatg tggtcgcatc agaaacatgc gcatttgacg tcgtcggcgc aacgtacctt 606661 cgcgaggtag agccgggaga aatgctgatc attaatgatg aaggcatgaa atcagagcgt 606721 ttttccatga atatcaatcg ttccatttgc agcatggagt acatttattt ctccagacca 606781 gacagcaata ttgacggtat taatgtgcac agtgcccgta aaaaccttgg gaaaatgctg 606841 gctcaggaat ccgcagttga agctgacgtc gtaaccgggg ttccggattc cagtatttca 606901 gcggcgatcg gctatgcaga ggcaacaggc attccgtatg agcttggctt aatcaaaaac 606961 cgttatgttg gcagaacgtt tattcagccg tcccaggctc tgcgtgagca aggcgtcaga 607021 atgaagctgt ctgcggtgcg cggggttgta gaaggcaaac gcgtcgtgat ggtggatgac 607081 tctatcgtgc gaggaacaac tagccgccgg attgtcacga tgctaagaga agcgggtgcg 607141 acagaggtgc atgtgaaaat cagttcaccg ccgatcgctc atccgtgctt ttacggcatt 607201 gacacttcca cacatgaaga actgatcgcg tcttcgcatt ctgttgaaga aatccgtcag 607261 gaaatcggag ccgataccct ctcatttttg agtgtggaag ggctgctgaa aggcatcggc 607321 agaaaatacg atgactcgaa ttgcggacag tgtctcgctt gctttacagg aaaatatccg 607381 actgaaattt accaggatac agtgcttcct cacgtaaaag aagcagtatt aaccaaataa 607441 aacttgaaaa atgacataaa ggcagcgcag ttcggctgcc tttctctttc tgccctcgtt 607501 cggggagata ttttgaaaag cgccttaaag gagtgaatag gatgtctgaa gcatataaaa 607561 acgcaggagt tgacatcgaa gccggatatg aagctgtaaa acgaatgaaa aaacacgtgg 607621 agcgcacgaa acggcttggc gttatgggca gccttggcgg ttttggcggc atgtttgacc 607681 tgtctgagct ttcttatcaa aaaccagttc tcatttcggg aacggacggt gtcggcacaa 607741 aattaaagct cgctttttcc atggataagc atgacacgat tggcgtggat gctgttgcaa 607801 tgtgtgtcaa tgacgtgctg gcacaaggtg cagagccgct gtttttcctc gattatttag 607861 cggttggcaa agcggaccca gtgaaaattg aacagattgt acaaggtgtt gcggaaggct 607921 gtgagcagtc aggttcagcc ttagtcggcg gtgaaacggc tgaaatgccg gggctctata 607981 cagctgatga atacgatatt gccggtttct cagtcggagt ggcagaaaag gacgaaatcg 608041 tgactggaga aaaaattgaa gagggccatc tgttgatcgg cctcagctcc agcggccttc 608101 acagcaacgg cttttccctt gtcagaaaag tgcttctgga tgatgcggag ctggacctcg 608161 atacaacata tgagccgttt gaacgcccgc ttggcgagga attgcttgaa ccgacaagga 608221 tttacgtgaa gcctgtgctt gccgcggtca aaagcggaaa aatcgacggc atggcgcacg 608281 tgacaggcgg aggatttatt gaaaatattc cgcgtatgct tccggaaggc ttaagtgcgg 608341 aaattgatca tggctcatgg ccgatcccgc cgattttttc tttcttgcaa gagtacggca 608401 agctaaagga agaagacatg ttcaacgtct ttaatatggg tatcggtttt gttttggcag 608461 tcaaagaaga gcatctgaca gatgtgatcg gaacgcttga aagccatggc gaaaaagcct 608521 atttaatcgg gcgtgtgaaa aaaggtgaag gcgtcacatt cggcggtgcg gcactttcat 608581 gaaaaagttt gcggtatttg catcaggaaa cggttcaaac ttcgaagcca tcgtcacgcg 608641 tttgaaggag gagaactggg atgcgtcagc agcgctcctc gtttgcgaca aaccgcaggc 608701 gaaagtcatc gaacgggcgg aagcattcca cattccatcc ttcgcatttg agccgaagtc 608761 ttatgaaaac aaggctgcat ttgaacaagc catcattgaa cagcttcgtc ttcacgaggt 608821 tgaattgatt gctcttgccg gctatatgag gctgatcggt gatacgctcc ttcaagcata 608881 tgggggaaaa atcattaaca ttcacccatc gcttcttccg gcgtttcctg gaatcgacgc 608941 agtcggacag gcgttccggg cgggtgtgaa ggtggccgga atcaccgtgc attatgtcga 609001 tgaaggaatg gatacaggtc cgatcatcgc tcaaaaggca atcgaaattg atgaacatga 609061 tacattggaa acaatcgaac agcgaattca caagcttgag cataaatggt atccgagtgt 609121 gattaaacag ctattaggat taaataacag aggtgaaaag gcatgaccat taaacgtgca 609181 ttaatcagtg tttcagataa aacaaatctc gttcctttcg taaaagaact gacagagctt 609241 ggcgttgaag tcatctccac aggcggaacg aaaaagcttc ttcaagaaaa cggtgtggat 609301 gtgatcggaa tttctgaagt gacaggcttt cctgaaatta tggacggccg gttaaaaacc 609361 ctacacccga atattcacgg cggccttctg gcggttcgcg gcaatgaaga gcatatggcg 609421 cagatcaatg aacacgggat tcagccgatt gacctcgttg tcgtcaacct ctatccattt 609481 aaagaaacga tttctaaaga agacgtcacg tatgaagaag cgatcgaaaa tatcgacatc 609541 ggcggacctg gcatgctgcg cgcggcatca aagaaccatc aggatgtcac ggttatcgtc 609601 gatccggccg attacagccc agtgctaaat caaatcaaag aagaaggcag cgtatctctt 609661 cagaaaaaac gcgagctcgc ggcaaaagta ttccgtcata ctgcggcata tgatgcactg 609721 atcgctgact atctgacaaa tgttgtcggt gaaaaagaac cagagcaatt cactgtgaca 609781 tttgagaaaa aacaatcgct tcgctatgga gaaaacccgc atcaggaagc aactttctat 609841 caaacagctc ttcctgtcaa aggctccatt gcgcaagcag aacagcttca cggaaaagag 609901 ctttcttaca acaacattaa agacgcggat gctgcagttc aaatcgttcg tgaattcact 609961 gaaccggctg ctgttgctgt gaagcatatg aacccgtgcg gcgtgggaac aggaaaaacg 610021 atcgcagaag cgtttgacag agcgtttgaa gcggataaaa catctatctt cggcggcatt 610081 atcgcgctga accgtgaagt ggacaaggca actgccgaag cgcttcacaa cattttctta 610141 gaaatcatca ttgcgccttc attcagccaa gaagcgctcg acgtcctgac tgcgaagaaa 610201 aatctccgtc tgctgacgct tgacgtatcc gccgctgttc aaaaggaaaa acagctgaca 610261 tccgttcaag gcgggctgct gattcaagat ttagatatgc acggcttcga tgatgctgag 610321 attagcattc cgacaaaaag agagccgaac gagcaagagt gggaagactt gaagcttgct 610381 tggaaagtcg tgaagcatgt gaaatcaaat gcgattgttc tcgcgaagga caacatgaca 610441 gtcggcgtgg gagcaggcca aatgaaccgc gtcggatcgg caaaaatcgc aatcgagcaa 610501 gcaggggaaa aagcgaaggg cagcgcgctc ggttcggatg catatttccc aatgccagat 610561 actgtcgaag aagcggcaaa agcgggcgtt acagccatca ttcagccagg cggatcgatc 610621 cgagatgagg attccatcaa aaaagcggat gaatacggca ttgccatggt attcaccggc 610681 atcagacact tcaaacatta aggggatgaa aacgacgtga atgtattaat tatcggtaaa 610741 ggcggaagag aacatacgct ggcgtggaag gcagcgcaaa gcagcctcgt cgagaatgta 610801 tttgccgctc ccggaaatga cggcatggca gcttccgctc agcttgtaaa cattgaggaa 610861 agcgaccacg cagggcttgt ctcatttgca aaacaaaatc aggtcggcct gaccattgtc 610921 ggccctgagg ttcctttaat tgaaggtctg gtggatgaat tcgaaaaagc gggcttacat 610981 gtgttcggtc cgtcaaaagc tgcggcgatc atcgaaggaa gcaaacagtt cgctaaggat 611041 ttaatgaaga aatacgacat tccgaccgca gaatacgaga cgtttacatc ctttgatgag 611101 gcgaaggcat atgtgcagga aaaaggtgct ccgattgtga taaaagcaga tggacttgca 611161 gctggaaaag gcgttactgt ggctatgaca gaggaagaag caattgcgtg cttgcatgac 611221 tttcttgaag atgaaaagtt cggtgatgcg agcgcgtccg ttgtcattga agaatatctt 611281 tctggtgaag aattttctct aatggccttt gtcaaagggg aaaaggtgta tccgatggtg 611341 attgcccagg atcacaagcg ggcgtttgac ggagacaaag gcccgaatac aggcggcatg 611401 ggcgcctact cgccagttcc gcaaatttcg gaagaaacgg tccgccatgc tgtagaaacg 611461 atcgttaagc cggctgcaaa agcaatggta caagaaggcc gttccttcac tggcgttttg 611521 tacgctggat tgatgcttac tgaaaacggc tcgaaggtca ttgaatttaa tgcccgtttc 611581 ggcgatccgg aaacacaggt cgtgcttccg cgcatggaat ctgatctggt acaggtgctt 611641 cttgatcttt tagatgataa ggaagttgac ttaagatgga aggataccgc ggcagtgagt 611701 gttgtgcttg catcagaagg gtatccggaa agctatgcaa aaggcacgcc gatcggcagc 611761 cttgcagcag aaactgagca ggtcgtggtc ttccatgccg gaacgaaagc agaaggtgga 611821 gagttcgtta caaacggggg gcgcgtcgcc aatgtgacgg cttttgatga aacgtttgaa 611881 gcggctagag accgagtgta caaagcggtt gatgaaattt tcaaaccggg actctttttc 611941 agaaaagaca ttggggcacg cgctttaaag gctgcccaaa aataagtgag gaaaacccgc 612001 agaatagctg cgggtttttt gttatcaaaa agcgggatgg cagctagaag aagaaagcac 612061 aacgagcgtg gttggttttc catgggccat cgaggtgtca ataaaatcct caagcgtatg 612121 taccgattca gtcacgacct ttgtcacata gctgtacatc cccgtgatgc ggtggttttc 612181 tgctacatca ggatgcgatg ttgcaaaggc ggcgtagtgc ttgcagcttt tcggctccat 612241 gagaataaaa gcggtgacat gcttgtttag tttttcgtaa cagatattcg cgctgtagcc 612301 ggtaatcact cctttgtctt ccagcttcct gacacgctcc gccgcgcttg gcgagctgag 612361 tccgacaagc tttcccagct caaccatcgt taatctgccg tttcgctgca aatgcgagag 612421 aatctgaagg tctgtatcgt ccatttgtct ggctccttta catatttagg cgaatgaatg 612481 aaaattcctt tgatcgtaag gtaatgctgt tgatttaact tcattgtagc atatggatgc 612541 cgtcttattt tttctataat aaagccatca atcagagagg gggcatcatg ttgccagaat 612601 tgcagcgctc tattacttgg atacaaggga cggcgttaac gattggggcg gttttaggat 612661 gcgggatatt aatcctgccg tctgtcaccg cggacacggc cggccccgct tctttatttg 612721 tttgggtgtt catgtccttc ttatcctttt ttcttgtcgg cacgctggcc cggcttgtga 612781 aaatagcgcc tagcgcggga ggaatcacgg cttatgtgca gctggccttt cagaaaaaag 612841 ccggggctat tttgggctgg atcatgttag ggtccgttcc gatcggcgtt cccatcatcg 612901 ctttgactgg cgcgcattac gtcagttaca tcacagaggc ggccgattgg cagattacat 612961 tgattgctgg ttgcatgctg gctatatcta ttttgcttca tatgagaggg attcaactat 613021 cagcaaacat tagtacactc gttatatgtg tcatcgtatt tctgcttgtc acttctattg 613081 ctgtgtcatt gccacacgtc acgatagcag aattcaagcc gtttcttccg catggctggt 613141 ctgccgctgg atctgtttct gttatgattt ttttctcttt tgtaggctgg gaaatgatta 613201 ccccgttggc tgaggaattt catcgtcctg aaaaagatgt cccgctcagc ttgtttttgg 613261 cagcgtcttg tgtggcgggg ctgtatatca tgctgtcatt tgtgaccgtg ggtactcatt 613321 catatggaga gaatggagaa attgcatcgc ttgccatgct catttcaaaa ggagcaggag 613381 aaagcggtgt atatgtcacg gtatgtttag cgctgtttat tacattcgcc accatccatg 613441 ccaatattgc cggtttttca agaatggtgt acgcattggc gagagagggg cacatacccg 613501 tattttttgg aaaactcagt gcgacaaaac gtacgcctat tcgcgttttg acagcgatgg 613561 ccgcagtgtt tggcttagtg cttgcagcgc atggtctgtt tcaaatcgat ttgacgactc 613621 tgttgaaagg gccgagcgcg gcttttatcg catcttacat atgtacaatg gcggcagcac 613681 tgaaactgct gggcaggaga gatataggct ggtggatggc gctcggggca tttgtggcgt 613741 gcgcggtgat ttattcattc agcggctggg cactgcttta tccggcagtg ctggcagctg 613801 caggatattt ctatatgaaa acaaagggtg ggcataaaaa aaagcttgat cacgttttgt 613861 gatcaagctt ttccatttat ccgttttgat gctcgttatt tccagaatcg ctgtgttgaa 613921 acatgtaggt cacaggacag aagcgcaaga ttcccgaacc cgctttcatg gcccccataa 613981 agatgtaaaa gagatgcatt ctgcaccaag gttttttcgt aaactttgca ctggcggctg 614041 acataatcgt caatccgcag gcgattctga acacggcatt gatgagactg atgtttggct 614101 tcaaggaaat ccgctccttt tacttaaaaa agttttttaa tcgaaccttc aaaaatttgt 614161 aacgttttta tcgtgcgtga tgaggaagga tgtgatacca tgagtctaat acatgtaaag 614221 gagagtatgt gaatgtccga acgcaccttt aactggaaaa acaaagacat cagggcacag 614281 gttgatgttg tagactcaaa gctgcttcca acgctccttt tacggaatgc tctcgtctta 614341 aatccatatg taaaacaatg gctgaaaaaa aacatttgga tttatcagga ccgcattgtt 614401 tatgtgggtc atgaacttcc gaatagagcc gaagaaattc atacgattga ttgtgaagga 614461 aaatacattg tgccaggtta tattgaaccg cacgcacatc cttttcaaat atataatccc 614521 caaacactgg cggaatatgt gtctcaatac ggaacaacga cattcgtgaa tgataactta 614581 tttttgcttt tgcaaagcgg aaaaaagaaa gcgcttacga ttttgaatga actcaaaaag 614641 cagcctgtcc agtatttttg gtggtcacgc tatgacctcc agaccgaggt tctgaacgag 614701 gaccacgtcc ttccatttga cgtcagaaaa cagtggattg aacatccgga tgtgattcaa 614761 ggcggagaaa tgaccggatg gcctcgcctg gtagatggtg atgatttaat gctccactgt 614821 atgcaagcta caaagaaaca gagaaaacgt attgaagggc attttcccgg cgcttctgat 614881 aaaacgctta caaaaatgaa gctgttcggt gcggattgtg atcatgaagc gatgacaggt 614941 gatgaagtga tgagaaggct ggaactgggc tattatgttt cccttcggaa ctcttccatt 615001 cgccccgatg taagaaaaat cttgcaagag ctgcatgaga agggcttccg ctattatgac 615061 cacttctttt acacgacaga tggcgcaacc ccgaatttct ataaaggcgg catgacaaac 615121 gagctgattc gcattgcgtt agaagaaggc gtacctgcaa tcgacgccta caatatggca 615181 tcatttaata tcgcaaagta ttaccaaatg gatgattatt taggagttgt cggaccgggc 615241 agactggcat cgctaaacat actggaagat ccgttaaatc cgaatccagt gactgttctg 615301 tcaaaaggga ccattctgcg tgaaaacggc tgtgatttga aggcgtttac aaagacggac 615361 tggcacaaag gcggtcttgt cccgcttgag ctttcatatg atatgacgat ggatgacttg 615421 cagttttcta tgccgatggg cgtgaaaatg cggaatgcgg ttattatgga gccatatatg 615481 attgagatcg acaattcgat ggaacagctc tcgtttgacc atgatgaaag ttatttgacg 615541 atgctcgaca gacacgggaa atggcgcgtc aatacgatga taaaagggtt tgcctcaagc 615601 gtgcagggat ttgtaagctc ctttacgacg acgggcgaca ttgtcgcgat tggaaaaaat 615661 aaagcggata tgctgctcgc tttcgcccgc atgaaagaaa tcggaggagg aattgtttta 615721 gcggagaacg gaaacattct gcatgaaatc ccgcttgcgc tgtgcggctg cgcctcttcg 615781 gaagcgtatg aagacgtgct tgagaaggaa caaaagctga gagatctttt gactgaaaga 615841 ggctatgagt tttgcgatcc tatctatacg ctgctctttt tgcaaagtac gcaccttccg 615901 tatatacgca ttacgccaag aggaatattc gacgtcatga aaaaaactgt actctttcca 615961 tcgataatgc gttaaaatat aaaagagcag ggagccgaca tatgaaaaaa tggatgacag 616021 tttgcgcgct gtgtttcgtg ttttttctgc tggtatcctg ccagcagaag gatgctgtcc 616081 cggatactgc aaagaagctg aaagctcctt taacggggct aaagactgaa cagaaagtga 616141 ctgaacgccg ccctgttgct gttgtggtga acaatcaccc gaaggcgagg ccgcagtcgg 616201 gtctgtctaa agccgacatt gtcatagaag cgctagccga agggcaaatc acaagatttc 616261 tggccatttt ccaaagccag atgcctgaaa ctgtcggacc tgtgcggagc gcgcgggaat 616321 atttcgtcac tctcagcaat ggctttgaca gcatatttgt ccatcacggc tggagtcccg 616381 gcgccaaaaa gcagctggaa tccggagctg ccgattatat gaacggattg gattttgacg 616441 gaagcttatt ttggagagct gatttcagca aaccgcccca caattcctat acgtcttatg 616501 attacataaa aaaggcggca gaacaaaagg gttataagct gaagcaggaa acaaatccgc 616561 tgctgtttca aacatcagat gcaaaacctg caaatgaatc ttacaatgtt cgggtagatt 616621 atggaacaaa taacgttaca aatcttgtcg aatacaacta tgataaaaaa gctgaatttt 616681 atacaagaag ctctgatggt gtcataacga cagaccggga aaccggaaag ccggttgcaa 616741 tgcaaaatat tttcattgtt gaagccagcc atcatattat tgatcaagat ggaaggcggg 616801 acatcgactt ggaatcagga ggaaaaggtc tgttgtttca gcacggaaac gtcattgaaa 616861 cagactggaa acaagtgaat ggcagaattg tgccggtaaa agacggcaag tggcttccgt 616921 ttgtgccagg aaagacttgg atcaatatcg tacctgatct tgatgcggct tccattagta 616981 aaggagaagg tgtgtaacga tgcaaatcga taaattacgc ggcaaagagc tggaccagtt 617041 atttaactcg atcttatcgc tgaaagacct ggaggaatgt taccgattct tcgatgatct 617101 atgcacaatt aacgaaattc aatcgctggc tcagcgcctt gaagtggcgc gcatgcttcg 617161 cgaaggaaac acgtatcata agattgaaac agaaacaggc gcttccacgg ctacgatttc 617221 ccgtgtgaaa cgctgcttaa attacggaaa tgacgcttat gaaatggcgc ttgaccgtgt 617281 gaaggagacg gaaacagagt cttcttccaa ataaaaaacc gccctgccgt ctggcaaggg 617341 cggtttcttt atgaaacaaa ttgatggatc aggttgtcga tattgatgat actgccatcc 617401 tctttccgat agacaacatg ctccttggaa aaatgaatcg gcgaattaat ccctgctgcg 617461 gctgcaaggt taaatagtcc ctcgcgcaat gaaataacgt agttgcagac acgatgctgt 617521 ttttcctcaa cgctcagtgc tttttgcaat ttcggatctg tcgtcgccac acctgccgga 617581 caggtgttgg tgtggcagac gagagcgcgg atgcagccaa cggaaaacat catgccgcgt 617641 gcgatgttaa caaagtcagc gccgagggct aaggcgaccg cgattttatc aggagtcagg 617701 agctttccgg aagcaaagat tttcagctgg ctgcgcaagc cgtactgttt aagaagcgtg 617761 tccacaatag gcagcgctgt cataatcgga aggccgactg tatccgcgag ctcgtaaaag 617821 gaagctccgg taccgccttc acttccgtcg atcgtgataa aatccggatg ctttccgctt 617881 ttctgcatat gagagaaaag ctcatgcaat tcttcaggat gccctgcgac cagtttgatg 617941 ccgactggct tttgtccgac atctctaagt ttttcaataa agtcgagcat ttcaggaggg 618001 tttgagaatt cataaaagcg gttcgggctg tcaatcgact ttccaggttc gacattccga 618061 atgtctgcca cttcctctga tactttggcg ccgtccacat ggccgccgcg ggttttcgct 618121 ccttgtgcca gctttagctc aaacgcttta atctggtcaa tcctgctttt tcttttaaat 618181 tcctcccacg aaaattcccc gtttcttttg cgcacgccga ataggcccgg tccgatttgg 618241 caaatgatat cggcgccgcc ctttaagtga tattcagaca atcccccttc acctgtattc 618301 atccaggtgc cgcctgccag atggagccct tttgagagcg ccgtaacagc ccgttctcca 618361 agagaaccgt agctcatggc agactggccg actaagccct tcacataaaa tggcttctcg 618421 catgtatgct cgccaatcac ctgtacatca tcaggatgga gaaaatacgg gtctgccttg 618481 atatgttcgg catgctcctt gcgtttgaac agattgtcag catccatttt atagatttgg 618541 gtttcaattt ttggcgtttg atttacatgc atttcttccc tttgttttgg aaacatagcg 618601 ttacggatat aatagccagg tttatcaaaa tctcttacag atccaaagcc catcattctg 618661 cttttgtatt tgccggagat gacggtttgc tcatattcct ttcgtgaaaa tggctgctct 618721 tcattgtcat tgctgtataa atactgtctg agctccggcc cgattttttc aaggatatac 618781 cgaaaccttc cgatgacggg atagttgcga agaattgagt gctcctgctg tttttcatcc 618841 tttatgtaga tccaggcaaa caagacgatc gggatagcga tgatcccaat gataaatgcg 618901 atgagtgcta ttatgatggt ttccatctct cagcctccct ttttatgtaa ccatttccac 618961 agtagaacac tttccaaaca atagcagaag gaatctggtg aaaaatgtgt gctcctgccg 619021 atacaggact caccatgcag gtactgccat atgctctctt tttttatgaa aaaagaatca 619081 aaacaccttt ttcagtgaat aacgagatta acggcttttt ccgtttttcc gcgctatgtg 619141 aatttgttat aatgtttaaa tggtaacaaa cgaatggagg aacgtatgac gtgtacgatg 619201 taacggagtg gaagcatgtc tttaaactcg atccaaataa agatttgcct gacgaacagc 619261 tggagattct ttgcgaatca ggaacggatg cggtcattat cggaggaagc gatggtgtga 619321 cagaggataa tgtcctgcgg atgatgtcta aggtaagacg gtttttggtg ccgtgtgtcc 619381 tagaggtatc agcgattgaa gcgattgttc ccggctttga cttatatttt attccgagtg 619441 tattaaacag caaaaacgcg gattggattg tcggaatgca ccagaaagcc atgaaggaat 619501 acggagaact gatgtctatg gaagaaatcg tggcggaggg ctactgcatc gcaaatccag 619561 attgcaaagc cgcggcactg actgaagcgg acgccgatct gaatatggat gatattgtcg 619621 cctatgcgcg tgtgtcggag ctgctgcaac tgccgatttt ttatttagaa tacagcggcg 619681 tgcttggaga catagaagct gtcaagaaaa cgaaggctgt attggaaacg tccaccttgt 619741 tttacggcgg cggcatcaag gatgcggaaa cggccaagca gtacgcagag catgcggacg 619801 tgatcgttgt aggcaatgcg gtgtatgaag attttgacag ggctttgaaa acagtagcgg 619861 ctgtgaaagg cgagtagtaa attgtacgga tttggtttat gatagaacgt atgttttgta 619921 taggcgggtg aacaaatttt gaattatatt agcaatcaat tactaagcgg tttaaacccc 619981 gttcagcagg aagcagtcaa aacaacggac gggcctcttt tgctgatggc gggagcgggt 620041 agcggaaaga cgcgtgtcct gacccataga attgcttatt taatggcaga aaagcatgtg 620101 gcgccgtgga acattctggc gatcacattt acaaataaag cggcacgcga aatgaaagaa 620161 cgtgtggaaa gcatcctcgg acccggcgcg gacgatatct ggatctccac attccacagc 620221 atgtgcgtgc ggatcttgcg cagagatatc gaccggattg ggatcaaccg aaatttctcc 620281 atccttgata cggctgacca gctttcagtg atcaagggga ttttgaagga gcgcaatctt 620341 gatccgaaga agtttgaccc gagaagcatc ctcggcacga tcagcagtgc aaaaaacgaa 620401 ttgaccgaac cggaggaatt ctctaaagtt gctggcggct actacgatca ggtggtcagc 620461 gatgtatatg ctgattatca gaagaagcta ttgaaaaacc agtcgctcga tttcgacgat 620521 ttaattatga cgacgattaa actgtttgac agagtgcctg aagtgcttga attttatcag 620581 cgcaaattcc agtacatcca cgttgatgag tatcaggata cgaacagggc acaatacatg 620641 ctcgttaagc agcttgccga gcgtttccag aacctttgcg ttgtggggga ttctgatcag 620701 tcaatctaca gatggcgcgg cgcggatatc accaacattc tttcatttga aaaagattat 620761 ccgaatgcaa gcgtgatttt gctagaacaa aactatcgtt caacgaaacg gattttgcgc 620821 gcggctaacg aggtcattaa aaacaactct aaccgcaaac cgaaaaattt gtggacggaa 620881 aatgatgaag gcatcaagat ttcctattat cgcggtgata atgagttcgg tgaaggacag 620941 tttgtggccg gcaaaattca tcagcttcac agcacaggca agcggaagct gtcggatatc 621001 gccatattat accggacaaa cgcgcagtcc cgtgtgattg aggaaacgct tctcaaagcg 621061 ggcttgaact ataacattgt cggcggcaca aagttctatg acagaaaaga aattaaagac 621121 attcttgcgt acctgcgcct cgtatccaat ccggatgacg atatcagttt cacgcgcatt 621181 gtcaatgtgc cgaagcgcgg agtcggcgcg acatcacttg aaaaaatcgc ttcgtatgcg 621241 gccataaacg gcttgtcctt tttccaagcg attcagcagg ttgattttat cggcgtcagt 621301 gccaaagcgg caaacgcgct tgacagcttt agacagatga ttgaaaacct gaccaatatg 621361 caggattact tatccattac agagctgaca gaagaaattc ttgataagac ggaatacaga 621421 gaaatgctga aggctgagaa atcgatcgaa gcccaaagcc gtttagaaaa tatcgacgag 621481 ttcctgtctg ttacgaaaaa ctttgaacag aaaagtgaag acaagacact cgttgcgttc 621541 ctgacagact tggcattgat cgcagatatt gatcagctcg atcagaagga ggaagagtca 621601 ggcggcaagg atgcgatcac cctgatgaca ctgcacgccg cgaaaggact ggagtttccg 621661 gttgttttct tgatggggct tgaagaaggc gtcttcccgc atagccgttc actcatggag 621721 gaagcggaaa tggaagaaga acgccgcctt gcgtacgttg ggattacaag ggcggaacag 621781 gagctttatc tgaccaatgc taaaatgcgc accttgtttg gccggacaaa tatgaacccg 621841 gaatctcgct tcattgctga aataccggat gatttattgg aaaacctaaa tgagaaaaaa 621901 gaaacaagag cgacgtctgc gagaaaaatg cagccgagac gcggccctgt ttcacgcccg 621961 gtatcctacg ccagcaaaac aggcggcgac accttgaact gggcagtcgg agataaggcg 622021 ggccataaaa aatggggaac aggaactgtc gtcagcgtga aaggcgaagg agaagggaca 622081 gagcttgata ttgccttccc gagccctgtc ggcgtgaaac gcctgttagc agcatttgct 622141 cctattgaaa agcagtaatt gaagaggaaa ggaagaagca gatggacaaa gaaacagcga 622201 agcagcgggc agaagaactg cgccgcacca tcaacaagta tagctatgaa tattacacct 622261 tagatgaacc gagcgtccca gatgccgaat acgacagatt gatgcaggag ctgatcgcga 622321 tcgaggagga gcacccagac ctcagaacgc ctgactctcc tacgcagcgc gtcggcggag 622381 ccgtgcttga agcgtttcag aaagtcaccc acggcacacc gatgctcagt ctgggcaacg 622441 cctttaatgc tgatgatctt cgtgatttcg accgccgtgt gcgccagtcc gtcggcgacg 622501 atgtggcgta taatgtggag ctgaaaatag acggtcttgc tgtttctctc cgttatgaag 622561 acggctattt tgtcagaggg gccacaagag gtgacgggac gacgggagag gatatcacgg 622621 agaatctgaa gacgatccgc aatatccccc ttaaaatgaa ccgtgagctg tcgatcgaag 622681 tgcgcggcga ggcgtatatg ccgaagcgtt cgtttgaagc actcaatgag gaacggatta 622741 aaaatgagga agaaccgttc gccaatccgc gaaatgccgc ggcgggatct ctcagacagc 622801 tcgatccgaa aattgcagcg aaacgaaacc tcgatatctt cgtctacagt atagcggagc 622861 ttgacgagat gggtgtagag acgcaaagcc aagggcttga ttttctcgac gaactcggat 622921 ttaaaacgaa tcaggaacga aaaaaatgcg gcagcataga agaagtcatt acgctgatcg 622981 atgagcttca ggcgaagcgc gcggacctgc cgtacgaaat agacggcatt gtcattaaag 623041 tcgattctct cgatcaacag gaggagctcg gttttacggc gaaaagcccg cgctgggcca 623101 tcgcgtataa gtttcctgct gaagaggtcg tgacgaagct tctcgatatc gaattaaatg 623161 tcggcagaac gggtgtgatt acgccgactg cgattcttga gccggtaaaa gttgccggca 623221 caacggtctc aagagcatcc cttcataacg aagatttaat taaagagaag gacattcgga 623281 ttttggataa ggttgtcgtc aaaaaagcgg gcgatatcat cccggaagtt gtgaatgtcc 623341 tcgttgacca gcgcacagga gaagaaaagg aattcagcat gccgacggaa tgtcctgaat 623401 gcggcagtga actcgtccgg atcgaaggag aagtggcgct tcgctgcatt aaccctgaat 623461 gtccggcgca aatccgggaa gggcttatcc atttcgtttc ccggaatgcc atgaacattg 623521 atgggctcgg cgaacgagtg atcacacagc tgtttgagga aaaccttgtc cgcaatgtgg 623581 cagatttata taagctgacg aaggaacgag tcatccagct cgagcgcatg ggcgaaaagt 623641 ccactgaaaa cctgatcagc tccatccaaa aatcaaaaga aaattcgtta gagcgcctgc 623701 tgtttgggct tggcatccgt tttatcggat caaaggccgc aaagacgctt gccatgcatt 623761 ttgaaagctt ggagaacctg aaaaaagcct ctaaagagga acttctcgcg gtagatgaaa 623821 tcggtgaaaa aatggctgat gctgtgatca cctattttca taaagaagaa atgcttgaac 623881 tcttgaatga acttcaggag ctgggcgtaa acacgctcta caaaggcccg aaaaaagtaa 623941 aagcagagga cagcgactct tactttgctg gtaaaacaat tgttctgaca ggaaagctgg 624001 aagagctgtc aagaaacgaa gccaaagcgc aaatcgaagc gctgggcgga aagctgactg 624061 gaagcgtcag caaaaacaca gacttagtca tcgccggaga agcggcggga agcaagctga 624121 caaaagcaca agagctgaac attgaagtgt ggaatgaaga acagttaatg ggagagctaa 624181 agaaataaga ggagtgtttt ctattgaaaa agacgttggc attggcggca acggcggcag 624241 tattaatgct gtctgcctgc tcgtcaggtt tcggggggga gaaggaggaa gagattacgc 624301 aaaagacggc gaaatcgtca gaaaaagcga ttgtcccgaa atataatatc tctgactcct 624361 attacaaaat ggtgctgccg tttaaggcag gcaaagcgcg cggcttaaca acggaacagc 624421 tgaatacaag gctggacatt gacgaatttg aaacagggct gatgcgcctt gcccaagatt 624481 ctttctcaac tgacgattat ctgttccaag aaggacaata tttagatgag gatacagtat 624541 taagctggct ggcacggaaa aaaacgggct ctgatttgaa aaaagccgaa aaagaagata 624601 agaacttcaa aaatgaaggc ttgaacccgg cgctcccgag ttctggttca acagaagaaa 624661 agaacgaaag cagcccaatt tatttagcat ccatgcttga gcacgattat ttagtcagaa 624721 aagacaagaa ttctatccag cttggcggcg tcatgatcgg actggcgtta aactcagtgt 624781 attactatcg tgaaaaaact ggcgacccgc aaaaagaagt ggagattaaa gacagcacgc 624841 ttcgccagca gggagaaaaa attgcacagg aggttattaa ccgcctccgc aaaaaagata 624901 acttgaagaa tgtgccgatt accgtggcgc tctacaagca ggcgtcaaaa acatcgattg 624961 tgccggggaa cttcatcgcc aaaacagagg tcaaagcagg ctctactgat atctcaaatt 625021 gggatgacat caatgaaaaa tatgtattct atccggcgga tacaaccaca gcagaaaagt 625081 acccggatga caccgaggtc tttaagcggt tcaaaaactc aattgaagaa tatttcccga 625141 actatacagg cgttgtcggt acagcgctgt atgaaaatga tgaaatgaag aaaatgaaga 625201 ttgacatacc aatgcaattc tacggaaaaa gtgaagttgt cgcgtttacc cagttcttaa 625261 cgggtgaagt gatggactac tactctaaga gctcagttga tgtcgaagtc aatatcacgt 625321 cctcagacgg acaggaagcg gtcattatcc gcaatgccgg agataaagag ccgactgttc 625381 acatttatga ctgatagaaa acccttgtgc catattggca caagggtttt tatgttacaa 625441 ttaacaggaa aagggaaaat attttcactt ctgccgaaac acaaatcaag gggaggtatg 625501 ttgatgctgg aaatcgtgtg aaaacaatca ttatcaaatc tatagcaatg aaaggatgtt 625561 agacgtgcat aaagatatca aaaaaatatt tcatgaagag caggttttgg cagaagctgc 625621 agcgagatac ggtttctcaa aagatcaggt gcgttttctg gctgatgcgg aaaactatgt 625681 atatgaatgt atgaaagaca atcaacctta tattttaaag attacccata cgattcggag 625741 atcttctgat tatatgatgg gagagatgga atggctccgt caccttgcaa tagggggaat 625801 ttcagtagcc aaaccgctcc cgtcgctgaa cggaaaagac gtagaagcag tgccggacgg 625861 aaacggcggg tcatttttat tgagagtgta tgagaaagcg ccggggcaaa aagtggatga 625921 atcggactgg aatgaaacgc tattttatga gcttggcaga tacacaggca gcatgcacag 625981 cctgacaaaa agctacaaat tgagcaatcc cgctttcaaa agacaggaat gggatgaaga 626041 ggagcaatta aagctgagaa aatatgtgcc tgaagatcag ataaaggtgt ttcagcaagc 626101 cgattctttg atgaatgaac tgcggaggct cccgaaaagc caggacaact acggcttggt 626161 gcatgcggat ctgcaccatg gcaattttaa ctgggatcat ggcaaaatca cggcatttga 626221 ttttgatgat atcggctaca actggtttgt taacgatatt agcattcttc tctacaatgt 626281 cctgtggtat cctgttgtgc catatgatga taaagctgcg tttacagaag aatttatgac 626341 gcattttatg aaagggtact gggaggaaaa tgagcttgac cctgcatggc tgatgataat 626401 acctgatttc ctccgccttc gccatatgct gatttacgga ttgctgcatc agatgtttga 626461 ccttaacaca ataggagaag aggaaaaaga aatgctggcc ggtttcagaa gagatataga 626521 gaatggcacg ccgattacag catttgattt ttcagcactg gtgtagatag aaaaagccaa 626581 tgggattcca gtcccattgg cttttataat gtatcacact tcacgccgac tacgccttca 626641 atggctttaa tgtcatagta gacatcggtc gtgtatctgt ttttatggac gcggaccttc 626701 acttccataa ttggaaaatc cttttcgcct aggtcgtcga tccgaacgga gtgtgctttg 626761 atatctcttc ttttcatttc ttttaaaatc tctgtcattt tgtctttatc agaaagtgac 626821 attctgatgc ggatgtcttt ttcctgcagg cggtcggggc cgatttttct gaccacccat 626881 gggagaaatt ccacactgat caggatgaac agaagactgg caaacgcttc tttataaaaa 626941 ccggctcccg tagcaagccc gagccccgct gccccccaga tcatggccga tgtcgtcagg 627001 ccggaaatga catcattgct ttttcgcagg atgacaccgg cgccgataaa cccgacgccg 627061 gagatgattt gtgccggcag acgaagcgga tccatcatga tgcggtagta tttagggaaa 627121 tgatatgccg cattaatact gacgatcgtc agcatgcatg agctgactgc gatgacaata 627181 caggttttta atccgagcgg cttatttttt aattcgcgtt caagcccgat gaccatgcca 627241 atcaatgtgg caatgcccaa tttcaataaa atatcaggat caatatacca gctcaacagc 627301 aaacttcccc cttctctatg gtgtttttaa ataaatatga ttttctcaca gtatttatag 627361 caaaacaaga gcacaaaagc caccaagctg cgcttgatgg cttattgctt actttttgcg 627421 ttttaacagc ttttccatga caccgaataa tcggtaagag gcttttgcag gacgttttgt 627481 gatcatgctg acaatgatgc cggcaatcat actgagaata aacccaggga tgatttcgta 627541 cacaccggtt gattttgcca ggccggttgt aatccagatc aacacggtcg cagccccgac 627601 aatcatggca gcaagcgcgc cccattcgtt cattcgtttc caatacagac tgagcagaat 627661 cgcaggcccg aaagctgaac cgaagccggc ccaagcgtat ccgaccaaat caagaatggt 627721 gctgttcggg ttcaatgaca agagtaccgc gataacggca atgactaaga cggacaatcg 627781 cccgatcatg accaattctt tatcagaagc ttttcgtctg aaaaatgacc ggtataaatc 627841 ctctgttaca gcacttgctg tgaccaagag ctgtgaggaa atcgaactca tgatggcagc 627901 caaaatagct gacaataaga accctgtaat taatgggtgg aacaagattt tagagaagat 627961 aatgaaaatc atctccggat cttttacagc aactccgaat ttatgggcgt atgcaacacc 628021 gattaaaccc gtcagcacgg aacctagaac tgtaatgatc atccagctca tgccgattcg 628081 gcgtgcaggt tttaaatctt taatgtcttt aatggccata aatcggacga tgatatgagg 628141 ctggccgtag tagcccaacc cccaggctaa ataggaaata atgctaatga cgctcgcgcc 628201 tttaaaaata tccaataaat gtggattaac agcgtcgatt tcatggaaag tcggagcaac 628261 gccgcccaca tgggtaaaag caacgatcgg cacaagcact agtgctgcaa acatgatcgc 628321 accctgcacg aagtcagtca gactgacagc aaggaaaccg ccaaacagtg tgtataacac 628381 gacaactgcg gtggtcagaa acaggcctaa tttgtaatcc gcaccaaaag cagattcaaa 628441 cagccgtccg ccagatacca taccggaaga ggtatacaat gtgaaaaaga tcatgatgat 628501 caatgcagat acgattttca gcagtgatga agaatgctgg aatcgtttat caaagaaatc 628561 aggaattgta atcgcatcat ctgccgcttc tgtataagca cgcagccttg gagccagcag 628621 caagtaattt gagtacgccc cgattgtaag acctaaagca agccataagg tggacagccc 628681 tgtcgcaaac atcgcgccgg gaacacccat cagcatccat ccgctcatat cggccgcgcc 628741 ggcagacaaa gcagtaacga atggtccgag gcctcttcct ccaagcatgt aatcattgat 628801 gtcagtggtt ttcttgaatg cataccagcc gattaacagc atggcaataa agtaaattcc 628861 taaagatata ataatttcaa tactcacgtt ttaccctctc ttcatttcta ataatgttgc 628921 atcacctctc aaattgatgg tgccagttaa gcagcctggc gtaagtgcaa aacaaaagaa 628981 attcttttgc gggtgcactt ggtaacttaa cctaacaaag tattcccggc cattcaagcg 629041 atgaaacatt gatcataagc tggaaatacc gttgcaaacc tagaagggaa taaagaataa 629101 aacgctttca aaaaataatt aaagtaaaaa tattcagaaa aatatttcgt ttctccttct 629161 cctcatttta gtataaaata tatagggtat tgtttcgaaa acacaggcct gtctcaaggc 629221 gttttgttgc tttaaagggc ttgtttttga tatgatcagt attatatgac ttaacggaga 629281 aatatgtgga ggtggatcat atgtcacgaa tttcaataga agaagtaaag cacgttgcgc 629341 accttgcaag acttgcgatt actgaagaag aagcaaaaat gttcactgaa cagctcgaca 629401 gtatcatttc atttgccgag gagcttaatg aggttaacac agacaatgtg gagcctacaa 629461 ctcacgtgct gaaaatgaaa aatgtcatga gagaagatga agcgggtaaa ggtcttccgg 629521 ttgaggatgt catgaaaaat gcgcctgacc ataaagacgg ctatattcgt gtgccatcaa 629581 ttctggacta aaggagggac acaagaatgt cattatttga tcataaaatc acagaattaa 629641 aacagctcat acataaaaaa gagattaaga tttctgatct ggttgatgaa tcttataaac 629701 gcatccaagc ggttgatgat aaggtacaag cctttttggc attagatgaa gaaagagcgc 629761 gcgcatacgc gaaggagctt gatgaggcgg ttgacggccg ttctgagcac ggtcttcttt 629821 tcggtatgcc gatcggcgta aaagataata tcgtaacaaa agggctgcgc acaacatgct 629881 ccagcaaaat tctcgaaaac tttgatccga tttacgatgc tactgtcgtt cagcgccttc 629941 aagacgctga agcggtcaca atcggaaaac tgaacatgga cgaattcgcc atggggtcat 630001 ctacagaaaa ctcagcttac aagctgacga aaaacccttg gaacctggat acagttcccg 630061 gcggttcaag cggcggatct gcagctgcgg ttgctgcggg agaagttccg ttttctcttg 630121 gatctgacac aggcggctcc atccgtcagc cggcatcttt ctgcggcgtt gtcggattaa 630181 aacctacata cggacgtgta tctcgttacg gcctggtcgc atttgcgtct tcattggacc 630241 aaatcggacc gattacacgt acggttgagg ataacgcgtt tttacttcaa gcgatttccg 630301 gcgtagacaa aatggactct acgagtgcaa atgtggacgt gcctgatttt ctttcttcat 630361 taactggcga catcaaagga ctgaaaatcg ccgttccgaa agaatacctt ggtgaaggtg 630421 tcggcaaaga agcgagagaa tctgtcttgg cagcgctgaa agtccttgaa ggtctcggcg 630481 ctacatggga agaagtgtct cttccgcaca gtaaatacgc gcttgcgaca tattacctgc 630541 tgtcatcttc tgaagcgtca gcgaaccttg cacgctttga cggcatccgc tacggctacc 630601 gcacagacaa cgcggataac ctgatcgacc tttacaagca aacgcgcgct gaaggtttcg 630661 gaaatgaagt caaacgccgc atcatgctcg gaacgtttgc tttaagctca ggctactacg 630721 atgcgtacta caaaaaagcg caaaaagtgc gtacgttgat taagaaggat ttcgaggacg 630781 tatttgaaaa atatgatgtt attgttggac cgactacacc gacacctgcg tttaaaatcg 630841 gtgaaaacac gaaggatccg ctcacaatgt acgcaaacga tatcttaacg attccggtca 630901 accttgccgg cgtaccggga atcagtgtgc catgcggatt agcagacgga cttccgctcg 630961 gcctgcaaat catcggaaaa cactttgatg aaagcactgt ataccgcgtt gctcatgcat 631021 ttgaacaagc aacagaccat cataaagcaa aacctgaact gtaaggggtg aaaagaattg 631081 aactttgaaa cggtaatcgg acttgaagtc cacgttgagt taaaaacaaa atcaaaaatt 631141 ttctcaagct ctccaacgcc attcggcgcg gaggcgaata cgcagacaag cgttattgac 631201 ctcggatatc cgggcgtcct gcctgttctg aacaaagaag ccgttgaatt cgcaatgaaa 631261 gccgctatgg cgctcaactg tgagatcgca acggatacga agtttgaccg caaaaactat 631321 ttctatcctg acaacccgaa agcgtatcag atttctcaat ttgataagcc aatcggcgaa 631381 aacggctgga tcgaaattga agtcggcggc aaaacaaaac gcatcggcat cacgcgcctt 631441 catcttgaag aggatgccgg aaaactgacg catacgggcg acggctattc tcttgttgac 631501 ttcaaccgtc aaggaacgcc gcttgttgag atcgtatcag agccggacat ccgcacgccg 631561 gaagaagcgt acgcatatct tgaaaagctg aaatccatca tccaatatac aggcgtttct 631621 gactgtaaaa tggaagaagg ctcacttcgc tgtgacgcca atatctctct tcgtccgatc 631681 ggccaagagg aattcggcac aaaaacagaa ttgaaaaact tgaactcctt tgcgtttgtt 631741 caaaaaggcc ttgagcatga agaaaaacgc caggagcagg ttcttctttc cggcggcgtc 631801 atccagcaag aaactcgccg ttatgatgaa gcaacgaaga aaaccattct tatgcgtgtc 631861 aaagagggat ctgacgacta ccgttacttc ccagagccag atctagtcga gctctacatt 631921 gatgatgaat ggaaggaacg cgtaaaagca agcattcctg agcttccgga tgagcgccgc 631981 aagcgttata tcgaagagct tggcttgcct gcatatgacg caatggttct gacgctgaca 632041 aaagaaatgg ctgatttctt cgaagaaacc gttcaaaaag gcgctgaagc taaacaagcg 632101 tctaactggc tgatgggtga agtgtcagct tacctaaacg cagaacaaaa agagcttgcc 632161 gatgttgccc tgacacctga aggccttgcc ggcatgatca aattgattga aaaaggaacc 632221 atttcttcta agatcgcgaa gaaagtgttt aaagaattga ttgaaaaagg cggcgacgct 632281 gagaagattg tgaaagagaa aggccttgtt cagatttctg acgaaggcgt gcttctgaag 632341 cttgtcactg aggcgcttga caacaatcct caatcaatcg aagactttaa aaacggaaaa 632401 gaccgcgcga tcggcttcct agtcggacag attatgaaag cgtccaaagg acaagccaac 632461 ccgccgatgg tcaacaaaat tctgcttgaa gaaattaaaa aacgctaata aaaaagcagc 632521 ccttagaggc tgcttttttt atggtcaaat tgagataaag acaagatgag ggcccgaagc 632581 ctttcaactt ctttgtcgtt ggttccggcc aaattggaca gcatgccttt aataatcggc 632641 ttgcgcggtt tatcctgagt caattcttcc tcgataacat caagtgacac ggtgatatcc 632701 tcgggcagcg tgctgttttc tttcactttc tgaatgtcct caagcagctg gtcttttccc 632761 gcaggcatcg ggttaaaaat gtcttttgat acaatcggat tgagtgcaga acggctcagc 632821 ccctgtacaa gatcatccag tctctcaata ataaaggctg agatttcttc tgcatcgata 632881 ttaagctcac cgttaaatac catcacgttc atataggaat gcacaatgcc tcttgccatg 632941 atggacagat ctgcgacata ccgctcgatt ccttcgccat aggataccag caaggcgttc 633001 cggtacagct tatccgtctc catggttact ttgtaaaagt attgcttgat ttcttgattt 633061 tccggaatga tattttcggt aagcaaaaga acgataaaat ctttatgatc gcgaaaatcc 633121 tcaaattgag cgccaatttg cttttttaac acttccttag gcggctttcc ggcgagatct 633181 tcttctatat ttttcatttt gttcatagac ataccgatat aatattcaca ggcagataac 633241 agcagcgctt ctttcgattt gaagtgcaaa taaaaagcgc ccttcgaaat gccgcattca 633301 ctggcgattt cttggatcgt cgtagctgcg aatccttttt tcgcaaataa acgaatgctg 633361 gtttttatga ttctctcttt tttttcattc atgacgtgct tccccttaat ccttgaaaaa 633421 tttagtaaaa ttttctggta tatgagttga cgttgttgcg ttataacgtt tagtattata 633481 tagaatgacc agtcagtcaa taaaaaatgt aatggaggat atgatgaacc acgttattaa 633541 tttcgttctg aaaaacaaat tcgccgtatg gctgatgacg attattgtaa cggcagccgg 633601 cttgtatgcg ggtatgaata tgaagcaaga gtctattcct gacgtgaaca tgccttactt 633661 gacgatcagc acgacatatc cgggtgcaac accaagccaa gtggctgatg aagtgaccaa 633721 accggttgaa caagccgtac agaacttgga cggtgtcagc gttgtgacgt cgacgtccta 633781 tgaaaacgca tcgtcggtca tgattgaata tgattatgag aaagatatgg acaaagcgaa 633841 aacagaagca gctgaagcgt tagaaaacgt caacctgcct gatgacgcga aggatccgga 633901 gatttcacgc tacagcttga actcattccc gattctgacg ctgagcgtgt ccagtgataa 633961 agataatctg caagagctga cgaaacaagt ggaggacagc ctcgtttcta agcttgaagg 634021 catagaaggc gttgcgtccg tccaagtatc aggccagcag gtggaagagg ttgaattctc 634081 tttcaaagaa gacaaactga aggaatacgg ccttgatgaa gatacagtca agcaagtgat 634141 tcaaggttca gatgtgacaa ctccgcttgg attgtacaca ttcggaaatg aagaaaaatc 634201 tgtcgtcgtc agcggcgata ttgaaacaat taaagatttg aagaatatga gaatcccgac 634261 ggcatctgct tcaagtgcag gcagcagcgc agcatctcaa gcaggtgcgc agagtgctca 634321 agcagcccaa agcgcgcaag cggcagcaca ggtgcagcaa agcgcaagca cagcagtgcc 634381 gacggtcaag ctttctgaca ttgctacaat taaagatgtg aaaaaagctg aatccgtttc 634441 acgcacaaat ggcaaagaca gcatcggcat caacatcgtc aaagcaaacg atgcgaatac 634501 ggtagaggtt gccgacgatg tcaaagctga gctgaaaaag ttcaaagaag accataaagg 634561 cttcaattac agcgcaactc tcgacatggc ggagccgatc acacagtcag ttgacacgat 634621 gttaagcaaa gccatcttcg gtgctatttt tgcgattgtg attattctct tattcttaag 634681 agatatcaaa tcaacattaa tttctgttgt ttcaattcca ttatcattgc tgatcgcact 634741 ccttgtgctg cagcagcttg atatcacatt gaatattatg acgctcggcg caatgaccgt 634801 tgccatcgga cgtgtagtcg atgactccat cgttgtgatc gagaacattt accgccgcat 634861 gagactcaaa gatgagccgc tccgcggaaa agccttggtt cgtgaagcga cgaaggaaat 634921 gtttaaaccg atcatgtcat caacgattgt gacaatcgcg gtattcctgc cgctcgcact 634981 tgtaggcgga caaatcggtg aattgtttat tccatttgcc ttaacgattg tttttgcgct 635041 tgccgcatcc ctagtgattt caatcacgct tgtgccgatg ctcgcacaca gcctgttcaa 635101 aaaatcatta accggtgcgc cgattaaagc gaaagaacac aaacctggca gacttgcaaa 635161 catctataaa aaagtattga actgggcgct gagccacaaa tggatcacgt ctatcatcgc 635221 ggttctgatg ctccttggaa gcttgttcct cgtaccgtta atcggtgcca gctacctgcc 635281 gtccgaggaa gaaaaaacga tgcagctcac atacagccca gaaccgggtg aaacgaaaaa 635341 agaagccgaa aatgaagctg aaaaagcgga aaaaatcctg cttgaccgca agcatgtcga 635401 tacggttcag tattcattag gctctggcag cccgcttgcc ggaggagatt ctaacggtgc 635461 gttattctat atcaaatatg aaagcgacac acctgacttt gataaagaaa aagataacgt 635521 tctgaaggaa atccaaaagc aatctgaccg cggagaatgg aagtcacagg acttcagctc 635581 ttcaggcaat aataacgaat taacatacta tgtgtatggc gattctgaaa acgatattaa 635641 agacacggtc aaagacattg aaaaaatcat gaaagatgaa aaggatctga aaaacgtaaa 635701 ttcaggcctt tccagcacat atgatgagta cacatttgtc gctgaccaag aaaaactaag 635761 caagctcggt ttaaccgcgt ctcaaatttc tcaggcctta atgtcacaaa catcgcaaga 635821 accgctcacc actgtgaaaa aagacggcaa agagcttgat gtgaacatta agacagaaaa 635881 agacgagtat aagagtgtga aagatttaga gaataaaaag atcacttccg cgactggcca 635941 ggaagtcaaa atcggcgatg tggcaaaagt gaaagaagga tcaacatcag ataccgtgtc 636001 aaaacgtgac ggaaaagtct atgcagatgt cacaggtgag gttacctctg acaacgtcac 636061 agccgtatca gctgctatcc agaagaaaat cgataagctt gaccaccctg ataacgtatc 636121 gattgacaca ggcggcgtat cagcggatat cgctgattcc ttcacgaagc tcggtttagc 636181 gatgctggca gcaatagcga tcgtttacct tgtgctcgtg attaccttcg gcggagcact 636241 agcgccattt gcgattctgt tctcattgcc gttcacagtc atcggtgccc tggtcggact 636301 ttacgtatca ggtgaaacga tcagtctgaa cgccatgatc ggtatgctca tgctgatcgg 636361 tatcgttgtc acgaatgcca ttgtcttaat tgaccgcgtg attcataagg aagcggaagg 636421 cctgtctacg agagaagcgc tcctggaagc cggctctaca cgactccgtc cgatcctgat 636481 gacagccatt gcgacaatcg gcgccttgat tccattagcc ctcggcttcg aaggcggaag 636541 ccaggtcatt tcaaaaggac tcggcgtaac ggttatcggc ggtttaatca gttcaacgct 636601 tctgacgctc ctgatcgtgc caatcgtata tgaagtattg gcgaagttcc gcaagaaaaa 636661 accgggaacg gaagaagagt aaaaaacaaa aagcctcagc tctgctgagg ctttcagctt 636721 gttgaaaaac cctcgcattc gttgtcaggt ctgcgcgtcg gtgctcacga attctacatt 636781 cgctccgctc caatgctccc ccttcctaga ctacaagggt tttcaatcaa gctgaaagaa 636841 tgttaaggat gacaaaagct caaaacaaga atcagttttg agcttttgtg cgttttcacc 636901 tgtaagatta tgtacatttt gttgcgattt ttttaactca tagtataatt aaaggttgtt 636961 agtgtaaaaa tggatcggat actcttaagt aggatgatga gataatgaaa cgtgcacgca 637021 taatatacaa tccgacttca ggacgggaga tctttaaaaa gcatcttgcc caggtcctgc 637081 aaaaatttga acaagccggc tatgaaacct ccacccatgc gacgacatgc gcaggagacg 637141 ctacacacgc tgccaaggaa gcggcattgc gtgagtttga cctgatcatt gcggcaggcg 637201 gagacggaac gatcaacgag gtcgtcaacg ggcttgcgcc tttagacaat cgtccgacac 637261 tcggtgtgat tcctgtcggc acaacgaacg acttcgccag agcgctcgga atcccacgcg 637321 aggatatttt aaaagcggca gatacggtca ttaacggcgt tgcccgcccg attgatatcg 637381 gacaggtcaa cggccagtat tttatcaata tcgccggcgg aggccgtctg acggagctga 637441 cgtacgacgt gccaagcaaa ctgaaaacaa tgctcggcca gcttgcttat tatttaaaag 637501 gaatggaaat gctgccttca cttcgtccga cagaagtcga gattgaatat gacggcaagc 637561 tgtttcaagg tgaaatcatg ctgtttttgg tcacgctgac aaactccgtc ggcgggttcg 637621 aaaagctcgc gccggattcc agcctgaatg acggcatgtt tgatttgatg atactaaaga 637681 aagcaaacct tgctgaattt atcagggtcg ccacgatggc gcttcgcgga gaacacatca 637741 acgaccagca cattatttat acaaaagcga accgcgtgaa agtcaatgta tcagaaaaga 637801 tgcagctgaa cctggacggc gagtacggcg gcatgctgcc gggcgaattc gtgaatctgt 637861 accggcacat tcacgtcgtc atgccgaagg agaaagcgga acagttggat gactaaaact 637921 tggcttggta agccaagctc agaatgttga caaaatccta aaacagtttt cgttttagga 637981 ttttgtcatc ttttcagcgt gattgaaaac ctttgaagtc taggaagggc gagcatcgga 638041 gcacagcgaa tgttgaattc gtgagcaccg aagcacaggc ctgacaacga atgcgaaggt 638101 ttgcctacac gctgaaactt ggcttgaata ggccaagttt ttctttcgct taaaactaga 638161 ggtgattata gatgaaaatg aaacccccag tagaaaaaaa tgaatactac gatgtgacat 638221 ttgaggattt gacacatgaa ggagcgggcg tcgcaaaggt ccaaggcttc ccgatctttg 638281 tgccgaatgc cctacccgag gaaaaagccc aaatcaaagt gacacgcgtc aaaaaagggt 638341 tcgccttcgg ccgcctgatt gagctgaagg aagaaagccc gcatagaacg gacgccccat 638401 gcccgattta caaacaatgc ggaggctgcc agcttcagca catgacctac gaaggccagc 638461 tcctgtttaa acagaaacaa gtcaaagacg tcttagaacg catcggcaag ctggaccttt 638521 caaaagtcac cgtgcacccg acactcggca tggaagaccc gtggaactac agaaacaaag 638581 cacaggtgcc ggtaggagaa cgggaaggcg gactcgtcgc gggattctat cagcaaagaa 638641 gccatgacat catcgacatg agcgcctgcc tgatccagca atccaaaaac gacgaagccg 638701 ttcaagctgt caaagacatt tgcgcaaact acggtgtcaa agcctacaac gaagaacgcc 638761 acaaaggctg gctccgccac atcatggtca gatacggcgt tgttacgggc gaaatgatga 638821 tcgtcttcat cacaagaaca agcgacttcc cgcacaaagc gaagatcatc gaagacatca 638881 cagcgcaatt cccgcacgtc aaatccatcg tgcaaaacat caacccaaac aaaacaaacg 638941 tcatttttgg caacgaaaca aacgtcatct ggggcgaaga atacatctac gacctcatcg 639001 gagacgtcaa attcgccatc tccgccagat cgttttatca ggtcaaccca gagcaaacaa 639061 aagtgctcta cgacaaagcg cttgagtacg ctgagcttca aggggaagaa accgtcatcg 639121 acgcttactg cggcatcgga acgatttctc tcttcctggc aaagcaggcg aaaaaagtgt 639181 acggtgtaga gattgtgccg gaagcaattg aggacgcgaa gcgaaacgcc gaattaaacg 639241 gcaacacaaa cgcagagttt gctgttggag aagcggaaac cgtgattcca aagtggtacg 639301 aagaaggcat tacagctgat acgctggtcg tcgacccgcc aagaaaaggc tgcgacgaag 639361 ccctcctgcg gacaattgtg gagatgaagc cgaagcgggt agtgtatgtg tcctgtaatc 639421 ctggcacgct tgcgagagat ttgcgggtgc ttgaggatgg cgggtacgtg acgcgcgaag 639481 tgcagcctgt ggatatgttt ccgcatacga atcatgtgga gtgctgtgtg ttgataaaat 639541 taaaagaata aatagtcaaa aatctatgct gatggaactg ttggttctct aaaacgataa 639601 ttgatttcaa tggttccatt tgcatgtact tctatttcat ctactaacaa atgaagcatt 639661 tcgggggtaa gtgtaccttc cttcatgaat ttatctaagc tctttttaaa atcaattatt 639721 tctttttcaa tcttttgaaa ttctaggtcc ttagatagtt ggtgaagggt agtttcaaaa 639781 tttgaaatat cttcattggt gatatttatg gctaattggt aatcttcttt agatataaca 639841 ccattagcaa gagagataac taaattggat ttatctctct ttttatcgtt taatttttca 639901 ttaatttcga ttatcttaga ttcgattttt tctttgtact ttaacgcttt ttcacttaat 639961 tctttaaaat aattttcctt actgaatttc aaatatatct tatttaggtt ggttattact 640021 ttatcagtta aatctatttc acttacgtaa tgatcactac atgcttttaa accatgttta 640081 ttataacttc cacaaacata accttttcga ttctttttaa aatgcattga cctcctgcaa 640141 tctttgcaaa ccgcagtatt tgtaaagaga tgtacttcag cttgaggtct ccttcttttt 640201 ctagttatta aaatctcttg tacaataaga aagtcttcta aaggtatgat tggttcgtgg 640261 cttttttcaa taattatttg gttttctagg ttaactgacc ttcttctttt actggtaaca 640321 ctcggtctat attctctaca ttgttgtagt gtcccagtat agtgaggatt ttcgagaatt 640381 tttcttattg aagatccgtg ccatttgtca gtagcgttct ttttgcgggc aagctgcgag 640441 ggactagtga ccccttcgtt atacaatccc cttgctattg catcaaagcc ttttccagca 640501 atatattctg aaaagattct aatatttact attttctctg cgtttgctga atttgagaga 640561 gatatgattg tagaacgaac tcaagaaggt aaaatgttgg ccaagcagaa tccggatttc 640621 cgagaaggaa gacccaaaaa gttcacaaag cagcaaatca atcatgcatt aacattacta 640681 gaaaatcatt cgtataaaca agttgaagat atgactggga tatcagtttc tacacttgta 640741 agagctaaaa agaagaaagc tgctgaagct ataaatggat aaatattgtg aattaattat 640801 tcaatatctt gagaaatttt tataaaagta atcaaaagtt taatggggga aacgaaatgg 640861 cgctcattga tttagaagat aaaattgctg aaatagtgaa tcgagaagat cattcagatt 640921 tcttgtatga attactcggt gtatatgatg ttccacgagc tacaattacg cgcttgaaaa 640981 aaggaaatca aaaccttaca aaacgggttg gtgaagtaca cttaaagaat aaggtgtggt 641041 ttaaggaggc taagaaagga aagctctttg acgcccttat tgatatagaa caacaagttg 641101 aatatctttc agctaagcca cgatatttat tagttactga ctatgatgga gtattagcga 641161 aagatacaaa aacattagag gctcttgatg ttaaatttga agaacttcct cagtatttcg 641221 atttcttcct tgcttggaaa ggtattgaga aagtagagtt tgaaaaggaa aaccccgctg 641281 atattaaagc agccgaacgt tttgcacgga tatatgatgt acttcgtaaa gaaaacaata 641341 ttattgagac taatagaggg ttagatttat ttcttattcg tttactgttt tgttttttcg 641401 cagaagatac tgacatcttc aaacgaaata gttttacgaa tttaattaag actttgactg 641461 aagaagatgg ttcaaatcta aataaattat ttgctgattt atttatcgtg ttagataaaa 641521 atgaacgaga cgatgttcca tcttatttaa aagagtttcc gtatgtaaat ggccagttgt 641581 ttactgaacc acatacagag ttggaatttt ctgccaaatc cagaaagtta attattgagt 641641 gcggtgaatt attaaactgg gctaaaatca atcctgatat ctttggttca atgattcaag 641701 ctgttgcttc tgaagaaagc cgtagttatt taggtatgca ctacacaagt gtccccaata 641761 taatgaaggt tattaaaccg cttttcctag ataaacttaa tcagtctttt ttagatgcat 641821 acgatgatta tacaaaactt gaaaatcttc taacacgaat cggcaaaatt aaattctttg 641881 atcctgcatg tggttcaggg aactttttga ttattaccta caaagaatta cggcgtatgg 641941 aaatcaatat tataaaacga cttcaagaac tcttgggaga gtatctttat gtaccttcag 642001 taactttatc tcaattttac ggaatagaga ttgaagattt tgcacatgac gttgcaaaat 642061 tatcactttg gattgctgaa catcaaatga atgaagaatt aaaaaatgaa gttcataatg 642121 cagtacgccc aacgttacca cttcatacag caggggatat tcgttgtgca aatgctatta 642181 gggttgagtg gactgaggtt tgtcccgcac aaggatctga agaagtatat gtttttggta 642241 atccaccgta tcttggttca aaaaaacaaa acaaagaaca taaatctgat atgttatcaa 642301 tttttggaaa agtcaagaat ggtaaaatgc ttgattatat ttctgcttgg ttttactttg 642361 gtgctaaata cgcttcaact acaaatgcaa aagttgcctt tgtatcaaca aattcagtta 642421 ctcaagggga acaggtttct atcttatgga atgagttatt caagtttgga attcaaatca 642481 attttgccta taaatctttt aaatgggcga ataatgctaa aaataatgct gcggtaattg 642541 ttgtgattgt aggttttggc ccgttagata ccaaagtaaa caagtattta tttgttgatg 642601 aaacgaaaaa gctagtttct aacattagtc cctatttaac tgatggtgaa aatattcttg 642661 tttcttctag gacgaagcca atttcagact tacccaaact gcattttggg aacatgccta 642721 atgatggcgg aggattactc tttaccatta cggaatatac agacgcaatc aataagtatc 642781 ctgaattagt tccctatttt aaaaagttta taggttcagt agagtttatt aatggtggtt 642841 tacggtattg tttatggctt aatgaagcaa aatatgaaaa aataaagtct aatcctctaa 642901 tacaagaaag aatctcaatt tcaaaaaatc acagggaaaa atcaacagat aaaggaacga 642961 ataaacttgc attaactccg tggaagttta gagatactca tgaaacaact aattattcca 643021 ttgttgttcc atctgtgtct tctgaaaata gattttatat tccaatggga ttagcaggtg 643081 cagatacaat tttgtcaaat ctaatttatg taatttacga tgcagaaatt taccttctag 643141 gcattttgat gtcacggatg catatgactt gggtaaaagc tgtagccgga agattaaaaa 643201 ctgactatag gtactctgca ggtttatgtt ataacacttt ccctattcct gaattatcaa 643261 caagaaggaa gaatgaaatt gaagaagcaa ttcttgaaat tcttgatctt cgtgaagagc 643321 agggtggtac attagcagag ctttataacc cttcaacaat gccaattgaa ttaaaagtag 643381 cacatgaaaa gttggatgga attgtagaaa gagcgtatcg tcaaaaacaa tttgaatctg 643441 atgaagaacg cttagaagta ttgcttaaat tgtatcaaga aatgacagaa cggtaggtgt 643501 aaggtgtatg gaaaatataa ttgaaattaa ttataaccaa actggtaaaa gtaagaaaac 643561 aaatgaatac ggtatgcgtg aaatgcaggc aagagctttt gaaaaacgta actcacaata 643621 tctcttagtt aaagcaccgc cagcttctgg gaaatctaga gctttaatgt ttatcggttt 643681 ggataagctc ataaatcaag gtttgaggaa agtgattgtt gctgtacctg aacgctctat 643741 aggttcttca tttaaaaata cggatttaaa aagttatggt ttctttgaaa attggaaagt 643801 tgatcctaga aataatttaa ctgttggcgg agataactct aaggttaaat cttttgttcg 643861 ttttatggaa tcggacgatc aggtgttaat atgtacgcac tctactttgc gatttgcgtt 643921 tgaaaaaatt gatgataaag catttgataa ttgtttactt gcaatagatg aatttcacca 643981 tgtatcggca gatgtcaatt ctcgattagg tgaattgtta agaagtatta ttcataattc 644041 atcagcacat attgtagcga tgactgggtc gtatttccgt ggagattctg taccaatttt 644101 attaccagaa gatgaggaat tatttgacaa ggtaacttat tcctattatg aacaacttga 644161 tggatatgaa tatctaaagg gatttggtat aggatatcac ttctatcaag gccagtacac 644221 atcagctatt aatgaagtat tggatacaaa taagaaaaca atcgttcata ttccaaatgt 644281 aaactcaggg gaatcgacaa aggataagta cgatgaagtt ggtaagatac ttgatatgat 644341 tggtgaagtt gaatatcaag atgatgatac tggaattatt tatgttaagc gacattctga 644401 cggtaaaaca ttgaaaattg cagatttagt agatgaccaa gttggaagag aaaatgtcgt 644461 tgcgtatttg cgtaatattg aagccctaga cgatttagat ataattattg ctcttggtat 644521 ggcgaaagag ggctttgact ggccgttttg tgaacatact ttgacagttg gttatcgtgg 644581 ctcacttaca gaaatagtac aaataattgg gcgctgtaca cgtgatagtt acaataaaac 644641 ctatgctcaa tttaccaacc taatcgcaat gcctgatgca aaggatgaag tagtgactta 644701 tacagtgaat acaatgctta aagctatttc tgcctcactt ttgatggagc aggtccttac 644761 acctgacttt aaatttaaac gtagaagaaa tgaaagtgaa aaatcttcta ctacaggaga 644821 attattcgtt aagggattga aagaaccatc aacagaaaat gtcaaaaaga ttattgaaaa 644881 tgatattaat gatttaaaag caaaaatcat gcaagattca caagtccaaa aaacatttag 644941 tggagaagta gatcccaaag tattgaacaa agtgttgatt ccgaaagtta ttcaaaaagt 645001 atatccaaat ttatcagatg aggaaattga ggaagttaga cagcacgttg ttctagatac 645061 agttatgaaa ggtgctaagt ctgaagttgt aggaagtaaa gaatttataa gaatggcaga 645121 taagtttata aacattgagg atttagatat caatctgatt gattccatca atccgttcca 645181 aaaagcattt gaggttctat cgaaagaatt gaactcacca gtgctaaaac tgattcagga 645241 aactattgat gcaaaacgta ttaattttga tgaagatgaa ctagtattca tatggccaaa 645301 ggtttaggaa ttttatcgtt caactggtag aagacctgat tcaaaatctg aagacccact 645361 tgaaaggcgt atgggtgaag ctgtattata catgcaagag cttaggagga aacgtgaaaa 645421 tggcaagtaa tagataccat tctattaatg aaatcatgga aagtcagctg ttttaccaaa 645481 tcacaacacc acctaagaaa acacaaaaag cccagtatga tcctgaagtt gaaaagtttt 645541 tggagattat tgaattcgtc aaagaaaatg ggcgagaacc ccaaaaagtc cctactgatt 645601 taactgaaag aagtttagca agtcgattaa ttgggattcg gaaagatcct gatcgtatgg 645661 aatatttgaa agagtatgat gaaattggat tacttgaagt aagatcgaag gaactaacaa 645721 ttcctaaaat ttcttcaatt gatgatattc taaaaagtgg cttatctgca ttattaggtg 645781 ataatttaaa taatgatata actaggtcaa tttttgatac aagttcactt caaaaggtta 645841 cgacaatgcc tgaatacgtt gcaaagcgta aaaaaataaa agattttgga aagtttgaag 645901 agctattcaa gaagtgccac aaggaaatta cagagggtaa acgaaaaatt ttaactttca 645961 aaaatgaaca agacatacag tcaaatagtt tttatatatt aaaaggagtt cttctttatg 646021 ttgaagatgt gggagaacgt aaaaaagcaa agggaaaaac caatgctaga cttcgatgta 646081 tatttgaaaa tggaacggaa tcagatatgt tactacgttc cttatcagcg gagttatata 646141 aacatggtag acgtgtgacc gacaatgaag atacattgtt ggataatgtt agagaagatg 646201 atgtttcgac tggctttatt tacgtactaa aatctttgag tacagatccg caaattagtt 646261 ccattaagaa tttatataag atcggtttta caactggttc agtagaaaat agaatcagga 646321 atgcagaaaa tcaatcaact tatctttatg ctccagtaga aattgtaacc acatatcaag 646381 tgttcaatat gaatgctagc aaatttgaga cggcaatcca tcatgcgcta gcaaataata 646441 atttggatgt ttctattttg ggggcaaatg gaaagatgtt agttcctaaa gagtggttcg 646501 ttgtcacact tgaagattta caagctgtaa tagatgagat tgtgatgatg gttcatcttt 646561 atgactaaat tagtatatta ggattttagt attaataata attttatagt agactatgaa 646621 aaaatttgat gccataacaa taacttgttc cgctttggag tttgtcacaa ttgtagaatt 646681 atgtgttgcg agtattaata ggaaggggtt gagcgaccgc aaaaaaaatt ttcggtgctg 646741 tccgcaaaag ggagtttggg tgttttgcgt tatatttggt tgtgtgaagg ttagcggaaa 646801 ctcaattcgt gaagttagga ttgcggttat tacgactgag tagtttcgtc atactctttt 646861 agcagttttt ctgtcttatg catttctttg agcatcggat tcatgtagtc gttagctgat 646921 tctagatatg ctctcgtcag agtgtctagt ttatttctaa ctttagagag gtcttcttcg 646981 aattttccat ccgatgattg aaggataaat tcttttgcct cttcatatct ttttaatatg 647041 tttttcacca ttggagttgg attcttttga tttattgttt ttattacagt gattgttaaa 647101 tttatttgtt ttattaattc ttttcttact gtcaaggtga tgctcctttt aaatctctat 647161 tctatttgag agttgctata tctgtttaat ggtttgatag actactcatc tttataattt 647221 agagcaattt ttacaacttg ttccgctgtg taatcttcat tgctccagaa aattaaatca 647281 cttggtgccg gataaggaac atttttctct aataaatcga gatattcact gactttctca 647341 tcatctaatg ttgggttcat taattccttt acaagaaaga tcaactcttc ttttgtcagt 647401 ttatccattg tttgccctcc aatagattgt atctccattg attttacaaa tgactttatt 647461 tcttctgata atgttatagg ttgtttgcat aatgatagat aattgtcttg agaaaagtta 647521 gtctcattat agagtttatt aattgtattt ataacaatat attcatatgg aaaacctcta 647581 aaatatcttt attttagatt ggtttataaa aaatagctca gcagagtagg gctgagccat 647641 tttttaatta tagaccgagg taactaatta caaattcttt atcatcctca tcttcaggca 647701 aaataccaag gtttttatat tcccatattg cgattctttc atatccatct aattctgagg 647761 ctaaaatatc atcataatta taatctaatt ggaattctcc gctacgatcc aatgttagtg 647821 taaggttagt ccaaacatca tcgttattat ttctgtgttc agttcttaat tcttcaaaaa 647881 gttctcttag ttctcttaac aacgtcttga aaatatcctt gcttacgttg taatggctag 647941 gtatatcttg tgaataaata atttgattat tttctggtgt tctgaaatga aaaagaacca 648001 ttgtggaatc atctaatact tctgcataaa gatatatctt tgtccattca ccaggtatga 648061 tgtcattgag tttttctcca ataagttgat acaaatcttg catcttccta gtttccattc 648121 ttctaacccc caggctgatt tttaatagag acgcttattt cttttctgct cccaattttg 648181 taggttacat cgaaatatga tggtctaagt gaatccccag aatagactgg ttctatttga 648241 actgctactt ttttaggtgg ttttttgctt agggcttttg cccactcctg ctccatctca 648301 taccatttcc caccgctcct attaatctga gaattcatcg gcacgatatt gtcaaactgg 648361 cctgagcctt tgaattgggt ggcgattaaa tggccgccgt catcgtcagg ctttcggtcc 648421 tggggctttc cagcattcgt ttgtgcatat tggtttcgtt tcgcttctcc cagctgcaag 648481 tctgctttga cacttgtaat tctaccatag ttgtcagtcg tgtacgtgta gccttctttt 648541 gttttgtaga tgatattagg cttcagcact ttctttctgc tccatcttgc gaaatgctcg 648601 ccgtatttga cggttaccgg cggtacatgt ggcgctggag ttcgtcttcc gcttgatgac 648661 gttccgtatg gtttcggcag gatgaccttg gcgaattttt gcagtccttc tttaagcgtg 648721 accccgttga ctgcgttgta aggaacgcct gccggcacta aatcatgacg gggatgatac 648781 gggagaatat ccgcaagtgt gagatctccg atttgattta acttggtttt gacgtgtttt 648841 tttgatactt caatgcctgt gtttactttt tgtttgatgt gatcaacggt ttgttttgag 648901 actgttatgg ctttttgggc tgttgctgat ttgcttgctg ctgttttgac tttggtcgtc 648961 actttggcgg ctgtgccagt ttttgagacg gctcctacgc cttttgtgcc gacaattgat 649021 gtgacaacag tgccaaccgc atatgacacc catcttgctc ttgagtaggt gtcaccattc 649081 accatgtctt tttgatacga ttcttcgatt gccgctgaaa tggcttcata cgttttgatc 649141 gggtgagcca tcgctccggt aatcgcttca acggttcctc ccggatctgt gaccatatcc 649201 cacaggccta cgaccgcgtc tttcccggaa tcataaaggc cgacggcaac ccctttgaag 649261 cctgcttcaa gctcacgcgt gttttcaatt tgggtgaagt atctctgttg ttcagctgtc 649321 agattttcat agccgatcgt ttttgccatt tcgtagaatt catcggcatc tgcataatcg 649381 tagtttttca gtctttcttt cagtttctca atctcgcgtt ccttcgcttc ctctttctta 649441 atcttcaagt aagcctcagt ccgcttttca atgtcgcctt ttttcttatg tatgtcactc 649501 tcacggtacg ccttggcgtt gtagtggatg ggtgtggcgt ttttgccttt acccgttgct 649561 tcttggagct tttggaagtc ggatttgatg aattgttcgt ttggttcaga cagggcgtat 649621 tctgttttca ggtcttcgtc caaggcgtcc aatttttcca gtgttttttt gcgtttgtcg 649681 ttggcatcgg ccagctcgtc tttgaaggtt tctgttgaaa acaggtcgag cgggaggatg 649741 tcgtcgatat cgtttaggat gtctttcatc gcttttttct gttcggacat gatggattta 649801 gattttttat tggcatttgc cagttcgtgc tccaggaagg attcttcgat gtatgcgtct 649861 gagaggcctt tgtcttcggc ggctccggcg atgctgttga aaaatgcgat tttcatgtcg 649921 atgtagtcga tccactggtc ggcgacgccg acgtggtcgt gatagaatgc cttgatgttg 649981 ctggcgcctt ttcctgagaa ttcactgtca ctgagatcag cgactccttt taacgctttt 650041 ctcaagttga ccatttgcgt tcttagttct ttgtactctt ttgcacggtc tgtcgcttcc 650101 gaaagcagtg ttttcgcttc aaatactttc atgaccattt cccttctttt gttcgctcaa 650161 tatcaaaatt ttaccacggg tcgggataag gtgggggtga gaacgtgttt tggtggaaaa 650221 atgagtcatt tggcatgtgt ctttattcgt ggagggattg gaggaaacat ggtcgaaatg 650281 atattgattg ctacacattt tttggaagtt tgtattctat attgtttttt aaggagcatg 650341 ttgatgacga aaaaacggat tacatttggt ttattagttt taatggtatg tgtcatcctg 650401 tttgttctgt atgttcagtt acgcaataaa gatagtattc ctgtccaatc ttccgccatt 650461 caccccgaag aagaccgcat cttttttatt tactccaatc ctttcataaa agaaagcgtg 650521 ctgctttcaa cctctacagg cgaacggttt aacaggcgta cgtttaaggt ggcggatgtg 650581 ccttatattc aaacgaaatc ttatgcatca acagaccttg tattattggc ggaacacgag 650641 cctttttact acacgctgga gaaggatgtg atcaaagagc atccgctgtc agatccattt 650701 gcgttttggt atgaggggaa ggatgtcact attgaggcct ataatgttga tacgacggga 650761 aatgagatcc acataaacga cagaaaaacg aaaaaggaat atacccttac cttgcctccg 650821 cttgtcacaa tgggggccag tgatgagaac tttatttata tcattcaaag catgtctatt 650881 tacgtgattg acagaaaaac agaggaaatg attgagaccc tgagcttagc ctcatacgct 650941 gatcaattcg cagactcgga ggaatttatc gtcgcgagct cggatcataa attgactgtg 651001 attgaaaaag ggacatggaa gacgacatat attgcgtatc ctgaagatct tgaatatgca 651061 gatactgtgt actatgacaa agaaagcggc agtttttacg tggcgtacga ggacaaagag 651121 ggtggagcga acttgctgga atatggggag gatttttcta ttcacacata cagcttgaaa 651181 ttcccttata tggaggcgaa gtttaagggg aatctattgt atatagttgc ccaggaagag 651241 cataaaaagg gcatcggcgg atacgtgggt gtgtttgata tccattctaa ggagatgctt 651301 tatcagtttg atttgcctga ggaacaggtg aaggttcagg attttgttgt ggttgacaat 651361 aagtgaatac tatatgaaat agaatgacaa agacccttgc ataaagggtt cttttttatg 651421 aaaaaaacaa attgacagga tgaaaaaaca atttcttcct tctatattgt tttcaaaatt 651481 tgggattgat agaatatgac atatctcata gagaaggagg gaagccgttg agtcaagcca 651541 taccgtcttc gcgtgttggt gttaagatta atgaatggta taaaatgatt cgccagttca 651601 gtgttccgga tgctgagatt ctgaaagcgg aggttgagca ggacattcag cagatggaag 651661 aagatcagga tttactgatc tattattctc tgatgtgttt tcggcaccag ctgatgcttg 651721 attatttgga gccgggaaaa acatacggga atcgccctac agtgacagag cttcttgaaa 651781 cgatcgagac ccctcagaaa aaactcacag gtcttttgaa atactactct ttgtttttcc 651841 gcggcatgta tgaatttgac caaaaagaat atgtggaagc gatcggatat tatcgcgagg 651901 cggagaaaga actgccgttt gtgtcagatg atattgagaa agcggaattc cattttaaag 651961 tggcagaagc gtattatcac atgaagcaaa cccatgtgtc gatgtatcat attcttcaag 652021 ccttggacat ttatcaaaac catcctctat acagcattag aacgatacaa agcttgtttg 652081 tgatcgccgg caactatgat gatttcaaac attatgataa agcgctcccg catttagagg 652141 cggcgctgga attggcaatg gacattcaaa atgacaggtt tatcgccatt tctctattga 652201 acattgcaaa cagctatgac agatcaggag acgatcagat ggctgtagaa catttccaaa 652261 aagcggcgaa agtaagcaga gagaaagtgc ctgatctgct tccgaaagtc ttgtttggat 652321 taagctggac attatgtaaa gcgggccaaa cacagaaggc gtttcagttc atagaggaag 652381 gattagacca tatcacagca cgttctcaca aattttataa agaattgttt ctgttcttgc 652441 aggccgtgta caaggagact gttgatgaac gaaaaattca tgatctttta agctatttcg 652501 aaaaaaagaa cctgcacgct tacattgaag catgtgcccg gagtgctgcc gctgtttttg 652561 aaagcagctg tcactttgaa caagcagctg cgttttatcg gaaagtgctg aaagcccaag 652621 aagatattct aaaaggagag tgtttatatg cctattaaga aaaaagtgat gatgtgtctg 652681 gctgttactc tagttttcgg aagcatgtcg tttccaaccc tgacaaactc cggtggattt 652741 aaggaatcga cagatcgaaa tacgacgtat atcgatcatt ccccttacaa acttagtgat 652801 cagaagaaag cccttagcta gggctttttc ttgctttacg gaagacgttc cattttccac 652861 atcgcggcat tccttctatt tctaacgcaa gacactcgaa acaaccaaac catttgaggt 652921 ataatggata aagtgaataa cagtatttag attgatatat atgaaagaga gtggaacatc 652981 atgggccgta agtggaacaa tattaaagag aagaaggcgt ctaaggacgc aaatacgagt 653041 cggatttatg cgaagtttgg ccgtgagatt tatgtggcgg cgaaacaggg cgagcctgat 653101 ccggaatcca accaggcgct gaaggttgtg cttgaacgtg cgaagactta cagcgtgccg 653161 aaaaacatca ttgaacgtgc gatcgagaag gcgaagggcg gagcggaaga gaattacgat 653221 gagcttcgtt atgagggctt cgggccgaac ggatcaatga ttatcgttga tgcgctgacg 653281 aataatgtaa accgtacggc gccggaagtg cgtgcggcgt tcgggaaaaa cggcggaaac 653341 atgggtgtga gcggatctgt tgcttacatg tttgacgcga cggctgtaat cggtgtggaa 653401 ggcaaaacgg ctgacgaagc gcttgaaatc ctgatggaag cggatgttga tgtacgtgac 653461 attttagaag aggatgacag cgcgatcgtg tatgccgagc ctgatcaatt ccatgcggtg 653521 caagaggcgt ttaaaaacgc gggtgtcgag gaatttacag tagcggagct gacaatgctt 653581 gcgcaaagtg aagtaacgct tccggatgat gcaaaggaac agtttgaaaa attgattgat 653641 gcattagaag atttggaaga tgttcagcag gtatatcata acgttgattt aggtgagtaa 653701 ggagtgagca ggctgttatg gcctgctttt tttgtcccgg aaattgtttt agctgtatgt 653761 aggcggccgc ctatacgatc tataagatat tctcatactc tggactgtaa cctatgtgaa 653821 ggagagagta aatatgactg atacaagaca tatgtatggc ggacctggtt ttggtcatta 653881 tcagggcttt ggtattggcc acccgggcta tggcatgcaa agcacaggct atccgggcta 653941 tggcatgtat ggaggccacc cgggctatgg catgcaaggc tacccagatc acggcataca 654001 tggaggagtc ggcggctatc cgggatatgg tgggtacggc ggttacccaa gcggcggcta 654061 tggaggctct ccgggaactg gaagctatcc gagcatgcac catgaaaatg atggccatca 654121 ccactattat caccatcatc atgatggaaa agataatctt catcaccatc atcaccatgt 654181 tggaaaggat aatcatcacc accatcatga tggtcattat ggccaccatc atcaccatat 654241 gggccactgg ggaaaagacg gttataaata aagaagatga tgataaaaag aggacactct 654301 tgcagatcaa gagtgttttt ttagcttttt tcttgactgt tcagtctgga aaatggtaac 654361 atttgtttca ggaggtgatc attttttggg gaggaataaa gaatttgata cggcgcttgt 654421 tcttcacagg gcgatagagg tttttggaga gtatggctac gaaggaacgt ctcttcagga 654481 tctgctctct catttaggca ttgcgcgcca aagtttgtat gatacgtatg gaacgaagcg 654541 tgatttgttt ttgtccgctg tgaaatcgta tcttgaaggg aaaaacgctg ccgttatgga 654601 aaggcttgaa gcgccaggat ctgtaaagga agccattcgt gatatttttc aggagggtgt 654661 caatgccctg agggatccgg aacgggcgaa ggcgtgctac attattaaca gcgcgattga 654721 acagatcccg catgaccctg agcttgcccg gtattttgaa agacaatcca agcagcttga 654781 ggacgctttt tatcacgggc ttttaagagc gaaggatcaa ggagaattga atggcgaaga 654841 tactgatata tctgcgcttg ctcggtacct gaatcagagc aggctgtcac tgacatttat 654901 tgcaaaagtg acggcagata tggatcggct tcaggaccat gttgacgtga gtttatcagt 654961 gcttgattaa catgtggtaa aggattcttt gcccatgtat gtactttttg gactgaatag 655021 tctagaaata aaaatgaggt gatgatgaat gttgatgaat gagtttgaaa aagcatgtga 655081 aacattgaga aagtttatgg cttatatgct tgagaaggac atgaagagct ggacggagct 655141 ttgggatgag aatgctgtat ttgagtttcc ttatgcgccg gagggatcac caaaaagaat 655201 agaaggaaaa gcggccattt acgattatat taaagattat cctaagcaga ttcatctttc 655261 ttcatttacc gctccgacag tgtaccgttc agcagactcg aatacggtga ttgcggagtt 655321 tcaatgtgac ggccatgtga ttgagactgg actgccttat cgccaaagct atatcagtgt 655381 catcgaaacg agagacggcc gcattgtgcg ttatagggat tattggaatc cgcttgttgt 655441 aaaagaggcc tttggaggat catttttgca aacagaggag agtgggaaat gatgaaacag 655501 aatccgattt taatcacggg cgggaccggc acagtcggca gccgaatcgc cagccgttta 655561 ataaagctgg gatacagagt gcgtattgca agccggaaaa agggcgcgct tgctgatgct 655621 gagtatgtgt attttaattg gaagtacgcc tccagtttta cgcctgctct ggaacaggta 655681 aaacagatct atcttgttgc tccggtcggt gtatttgatc cggctcccta tgtgcttccc 655741 tttttaaagg aagcaaagcg tctcggcgca aagcgggtag tgatgcaaag tgcgtctgtt 655801 gtctccgaga acggtcccgt gtttggcgcg cttcaccagg cagtgcgcga gtttccagaa 655861 tggacggtgc tgcggccctc atactttatg caaaatttca tcaatgtcca gcaccgcatg 655921 tctattcaaa cggaggggcg catcacaacg gcttcgggtg aaggaaaact tgggtttatt 655981 gacgctgatg acatcgcaga aacagccgtc agggctttga ttgatgatgt tcctcatcaa 656041 acacatcata ttctgacagg tcccgaggcg ctgagctatg ccgaagcggc ggagatcatt 656101 ggagctgcgg cgggacgccg ggtggagcat gtcagcattt ctcgttccga gctgcagcat 656161 aaaatggagg caggaggttt gcccgcggat tatgcccatt ttatggcgaa gcttgatgag 656221 gcaattagcc atggtgcgga acatcgggta acggatacag tgaagcgtgt gacgggaaaa 656281 gaacctcgtt cgctgtcaga gtttgcggct gctcatgctg catattggac ctcattttgg 656341 actgaatagt ctagaaagac cttcggcgct tccgaaggtc ttcttattga aaaagctaag 656401 tcgtgtttta gtcataatca tgcctcctgc ctcataccta ttaaggtcat tgtttttgag 656461 aaaggaggag ccggaatgaa ggatatgcag ccgtttacgc ctgtcaaatc atatacgccc 656521 tttcacagcc gttttgatcc ctgtccgccc atagggaaga aatattacag aacgccccct 656581 aacctttata tgacctttca gcctgagcac atggagcagt tttcgccgat ggaggctttg 656641 aggaaaggca ccctttggaa ggatctctat gatttttatg aaaaccctta tcgaggggga 656701 gacgcacatg gcaaaaaagg ttgacgccga atattatcgt cagctagagc aaatacaggc 656761 tgctgatttt gtgcttgttg agctgagtct ttatttaaat acacatcctc atgatgaaga 656821 tgcgttgaag caattcaatc aatattccgg ctattcaagg cacttaaaaa gacagttcga 656881 atcctcttac ggaccgcttc tgcagttcgg caacagcccc gcgggcaagg attgggattg 656941 gggaaaaggg ccatggccgt ggcaagtata aggaggaatg cctgaatgtg ggtgtatgaa 657001 aagaagctgc aataccctgt caaggtcagt acgtgcaacc cgacgctggc gaagtatttg 657061 attgagcagt atggcggagc ggacggcgag ctggccgcgg ctctccggta tttgaaccag 657121 cgttatacga ttcctgataa ggtcatcggc cttttaacag atatcggcac ggaggagttt 657181 gcccatttgg aaatgattgc gaccatggtc tataagttaa cgaaagacgc cacaccggag 657241 cagctgcgtg aagctgggct tggcgatcat tacgtcaatc acgacagcgc gcttttttat 657301 cataatgcgg cgggcgtgcc gtttaccgcg agctatatcc aagcgaaggg cgatccgatt 657361 gccgatttat acgaagatat tgccgcagaa gaaaaggcgc gggcgacgta tcaatggctg 657421 attgatattt cggatgatcc tgatttaaac gattccctgc gttttttgcg tgagcgtgaa 657481 atcgtacact ctatgcgctt cagagaagcg gttgaaattt taaaagaaga acgggataaa 657541 aagaagattt tctaataggc agattggcct ctctttcata caccctttta catacagaga 657601 aaatggtctg tttttgcagt ttggtctgca ttataatcaa ggtgtgtgtg caagcttact 657661 ttttgattgg gaggccttta tgacagcttt taagattgag aacgaaacga ttgcagatgg 657721 attttacgcg tgtccggccg tctatgagga tgcagaatcg attaccgggt tgctcgtccg 657781 aacagctgaa tggctccggg atcggggttc taaccaatgg agcggacttc tcaaagggca 657841 agatatacat gatatcacgg ggtcaattga aaagggacat gtgtttgtgt ttaaaaaaga 657901 tgaagagctt gcggctgtcg tgatgctgct gcctgcaccg agcgagtggg accggacgct 657961 ttggggagac gatgggcatg aggagtccat ttatttacac cgcctcgcag taagccgccg 658021 gtttgcggga caggggcttg gagcccgcgt ccttcagtgg gcggagacgg gcatacactt 658081 tccggaaaaa acgcggatcc ggcttgactg tgtcgctgat agtgacgccc tgcattcctt 658141 ttatcggcgt atgggatatg aattcatggg tgctgatgcg tccggatatc atttgtttga 658201 gaaagagatt acggcagaat aagcgtcctt tgcagggggc ttttttgtct ttttctaaaa 658261 gggaggcagg cgatgtgtgg tcaatattat ttgtgacagg gattgtgacg gcttgtctgt 658321 ttgctggcgt atccgtattg atgcggatga gatttcctga caaaagtcgg ccggaatgga 658381 tgttggccgg gctgatcgtc cttggtgtgt ttgcgatctg gtacagcctc gtgtatgtac 658441 gcggctggga aggggctgcg ctcggaatgc ttggattcaa tgtcattttc ggagccattg 658501 ccggatattt gatcgataag gccatccggc gttacaggaa aagataaggc tgctgccgtc 658561 tctcaacagg tcgaaatttt cacagaccgg caggaatttt ctttcgaaag gagaaataca 658621 tattacttta aaatgaaagc gttttccaaa gcaggaaggt gatgttgatg atacacagtg 658681 tggcaaatgg gctgaatcat ttttgtacgt gggtgatgag actggcctat ttgaatgtgc 658741 tttggatttt gttttctctt gcaggcctgg ttgtatttgg gctgatgccc gctactgccg 658801 cgatgtttac agtggcgaga gaatgggcga aggggaatac agatgccccg gtgttttctg 658861 tcttttttcg gacgtttaaa aaggaatggc gggcatcaca gatcctcggg cttatcgttg 658921 tgacggctgc cctgtttctg tttgcggata tgcggatagc ggctcagatg gaccagcctg 658981 tgctcgtcaa tgtattcgtg agcattagtt tgattttcgc gtttgttgtg ctgtatgtgt 659041 tcccggtatt ttctcatttt gacgtaaaaa tcagagaggt gctgagcatc agctttttca 659101 ttgccttcag tcgtccggcg gtgacgcttt tgatggcagc gggcgctgtc ggtgtgcttt 659161 gtctcgttct gtttcatgtc acgtttctat tgtttttcag cgggagttta ctcagcctga 659221 tcttaacgaa gctgtccttt aaagcgtttc ggtcaatgga tcagcggcag gagaaagaaa 659281 aggcggcatg aagaaaagag ttgctggctg gtacaggcgg atgaagatta aggataagct 659341 gtttgtgttt ctatcgttga ttatggccgt atcctttctg tttgtataca gcggggtcca 659401 gtatgccttt catgtgtatg atgagcagat ttaccgcaag tcctcggagg tgcttcggat 659461 gtcttctgaa aggatcgaag acgagctgaa gaagatagag gatgtgtcat atgaaatcat 659521 tacagacgaa cagattcagc gcatcctgag catgcaaaat cgggatgata cgtatgatca 659581 atatcaaatg aagcaggagc tgtgggatca gcttgcggga tatgccagcg atgaaaagta 659641 catcgattcc attcatgtga ttgatgcccg cggctcagag tattcagccg gaagcagttc 659701 ttcagatctt ttgcagcagg agcaggaaga ggtatttaag cgagcgaaag cgaaaagtgg 659761 aagaaatctt tggatgacgc tcggcgggtc agaccccgtc ctgatttcag cacggcagat 659821 caggtcctat caccagctga gtctgaacgg cttgggcatg gtactgatcc aggtcaatgt 659881 aaaacagatg attcgtgatg tgccgaagga ttggggcgat tcagtcggag acattatgat 659941 tgctgaccaa ggcggtaatt tggtgtatac ggcacatgca tcagcgcatg ttcctgaggc 660001 agcaaaagag acgttgaagc accccggtta tgacttgata aaaaagaatg gcaaacgtta 660061 ctttatttct tatcttcaat catcctacca aaattggagc tactataacg ttatcccctt 660121 tgatcagatg ttcgcaaaaa tttcctttat gaaaacagtg atcggcacat gctttcttct 660181 ctttttctgt gtggttttgc ttttcggaag gaaaatcgcc aacagcatca cggagccgat 660241 tgaacagctt gtgaccgcga tgaaatcggt acagcacagc ggcattgaag caggtgtgtc 660301 gctttctctg ccggaacata cacaggatga ggccggcatg ctgaaccgcc attttactgt 660361 catgatgaaa cggattaatg agctgatgga agaaaatgtg gaaaaacagc tcatcattaa 660421 agaaaccgaa ttgaaagcac tgcaagccca gatcaatccg cattttttat ataacacgct 660481 cgagtccatc aattggctgg ccaaggcgaa tcagcaaaag caaatctcaa aaatggtgga 660541 atcgctcggt tttcttctgc gaaacagcat acatatgaag aaggatatcg tgaccattca 660601 ggaggaggcg gacattgtac gtcactatat gaccattcag cgatttcgat ttgaagagcg 660661 cctgaaattc acgttggata ttgacgatga ggtgaagcat tgcctcattc cgaaactgac 660721 gctccagccg cttgcggaaa atgcgattca atacgcgctt gaacccttta caaggccatg 660781 cgccatccgg attcaggcga aaaaggcgaa gggctgtgtc tgtattacgg tcgaagataa 660841 cggccctggc atggatggac ggattcttga atcaacgggt ggaagaggaa tcggactttg 660901 gaatattcgc gagcgcatca gcctgacatt cggagagcca tacggattgc ggattcatag 660961 tgagcatgaa aaggggacga ggattgtgat cacaataccg tgccgaaatg aggtggtgtg 661021 atgtataaaa tactgctggc tgatgatgag aggattatcc ttgatggaat ggcgggaatc 661081 attgagtggg agtcgcttgg cgcctcattg atcggaaaag cgcagaacgg acatgaagca 661141 tatgaaaaga ttgtacataa gcagccgcat atcgtcatca cagacgtcaa aatgcccggc 661201 atggacgggc ttgagctgat caaaaaggtg tcagccgtca gcccgtcggt gcaatttatc 661261 gtcctgtccg ggtttggaga gtttgagtac gcaaaggaag ccatgaaata tggggtgaag 661321 cattatttgc tgaaaccctg caatgaacag cagattatca gctcgctgga ggaaatcatt 661381 gctgagctga agcggcaaga tgtgcacaaa aagaaaacag cccatctgaa acacgagctg 661441 gaccatatcc gttcctttgc agccgatcaa tacttggaag gcttgatcgc cggtgtggcc 661501 cagctttctc cgccgccttc acttgccgga aaaaagatcc gcctcttgat cttaaaaggg 661561 gaacaatcta ttgatgctgc agccagagag gcactcggat cggcactgac agcggtttgc 661621 agcagcggtg aatggaccgt gctcgccgta gaggagaacg ccgctgaaaa ggtggcggag 661681 gtttttgcgg accgcaagat ggccatcagt caggcgggag aactccggca cgcggggcag 661741 ctgtttcgtg acacagctga agcgtctggt gacctgcatg ggagcgcagt gatttcaaaa 661801 atgatcaggc ttattgccga cgagctcgga aatccgaatc tgtccttaaa atgggcggcg 661861 aaggatatgc tgtttatgaa tcctgattat ctcgggaagt tatttaagca ggaaacaggc 661921 gagaaatttt cccaatatgt tacacgggtg cgtcttgagc atgcgatgaa gcagatgaaa 661981 ataaggaggg acgtgagcgt ttcagaaatt gctgaagaaa tcgggtttgg cgataatccg 662041 aagtatttca gtcttgtttt taaaaaatat accggtctga caccgtcaga attcagaaga 662101 aaacagggag gcgcttccgc aggatagcca tctctgtttt tttgactttc gccactgttt 662161 tttgagtgtt tcgccctatc cgaacgcttt aaaataaaat gtaagcactt acattaaagg 662221 ggggattggt ttgaagaaga tttgttacgt gctgttatcc cttgtctgcg tctttttgtt 662281 cagcggatgt tcagcgggtg aagaggcctc gggaaaaaaa gaagatgtta cactcagaat 662341 cgcgtggtgg ggcgggcagc caaggcatga ttatacaact aaggtaattg aactatacga 662401 gaaaaagaat ccgcacgtcc atattgaagc ggaatttgcg aactgggatg actactggaa 662461 aaagcttgcg cccatgtctg ccgccggcca gcttcctgat gtcattcaaa tggataccgc 662521 ttacttagcc caatacggaa agaagaacca gctggaagat ttaacgccgt atacaaagga 662581 tggaacgatt gacgtcagtt caatcgacga gaatatgctg tcgggcggaa aaatcgacaa 662641 taagctttat ggatttacgc taggtgtcaa cgtgctgtct gtgattgcca atgaagattt 662701 gctgaaaaaa gccggtgtgt ctatcaatca ggaaaactgg acgtgggagg attacgagaa 662761 gctggcgtat gatcttcagg aaaaagccgg tgtctacggt tccaacggaa tgcatccgcc 662821 tgatattttc ttcccttatt atttgcgcac aaagggtgag cgcttttata aagaagacgg 662881 cactggcctc gcgtatcaag atgatcagct gtttgtcgat tactttgaac ggcagctgag 662941 gctagtgaaa gcgaaaacgt ccccaacacc tgatgaaagc gcacagatta aagggatgga 663001 agacgatttt atcgtcaaag gcaaatcagc gattacatgg aactactcca atcaatattt 663061 gggctttgcc cggctgacag actcgccgct gtctctctat ctgccgccgg agcaaatgca 663121 ggaaaaggcg ctgacactga agcccagtat gctgttttcc attccgaaaa gctctgagca 663181 taaaaaagag gcagcgaaat ttattaattt cttcgtgaat aatgaggaag cgaaccagct 663241 gattaaaggc gagcgaggcg ttccagtctc cgacaaggtg gcggatgcga ttaaaccgaa 663301 gctgaatgag gaagaaacca acatcgtgga gtatgtagaa accgcgtcaa aaaacatcag 663361 caaagccgat ccgccagagc ctgtgggaag cgcggaggtc atcaagctgc tgaaagatac 663421 gtcagatcag attctgtatc agaaggtatc gccggaaaaa gccgccaaaa cgttccggaa 663481 aaaggccaat gagatattag agaggaataa ttgacgggaa atggggctga cgcaatgaaa 663541 aaaagccgga gtataagaaa agacaatctg gcgggatatg cttttatttc tccgtttatc 663601 atcgggttcc tatgctttac ggtgattccg atgggggcgt ccctgtttct gtccttcacg 663661 agctatgact tgtttacggc gccgaaatgg atcgggctcg acaactttaa ggaaatgttt 663721 acgggtgacg aaaagtattg gcagtctctg aaggtgacgt ttacgtatgt gcttgccggg 663781 gttccgctcc gcctcggctt cgcgcttttt atcgctgtca ttttaaacaa tgcagcaaaa 663841 ggaacggcca tttacagaac gctcttttat ctgccttcga tcatcggcgg gagcgtcgcc 663901 gtggcgatta tgtggcgcaa tatttttggc aatgacgggg tcatcaatgc gctgctgttt 663961 tttgtcggga ttgatcaaaa aattctttgg taccagaatc cgacaagtgc gctgtggaca 664021 ttgattctgc tgtccgtctg gcagttcggg tcgtcaatgc tgattttttt ggccgggctg 664081 aaaaacattc cgtcttcgta tttggaagcg gcaagtgtgg atggggcaaa tcgggtgcag 664141 cgtttcttca agatcacgct tccgatcctt acaccgatta ttttctttaa cctagtgatg 664201 cagacgattt ctgcttttat gacatttaca cctgcctata tcatttcgaa gggcgagggc 664261 gggccgcttg acgggacact tctctattcg ctctatttgt tccagcgtgc gtttaactat 664321 tttcaaatgg gctacgcatc ggcgatggcg tgggtcatgc ttgtcattgt cgggctgatt 664381 acgctcatat tgtttaaaac atcgtcatat tgggttcatt acgagtcaaa ggaggaatga 664441 cggatggagc cggtcaacca gcctgtcaga gaagccccgg tttttgagag aaaaaaagcc 664501 gggcgcgtca gtcccaaacg catactgttc catgttttta cggcaacgct ggcggtgttg 664561 ctgctgtacc cggttatttg gctgtttgtc agctcgttta aagaaagcgc cagtattttt 664621 acaacctcac attctctcat tccagaccct tttattctca gtaactatgc tgaagggtgg 664681 aagggcattg cgggacagcc gtttctgacg tttattaaaa actcggcgat tattgtcggg 664741 ctgtcaacaa tcggtgccgt catgtcatcg gctgtcattg cgtacggatt tgcgcgtata 664801 ccgtttaagg gaaaaaaatt ttggtttgcg tgcatgatgg ggacgttaat gctgcctcat 664861 gaagtgttga tgattccgca gtatattatg tttgcgaaat tagactggct gaattccttt 664921 aaaccaattg tcgttccgca atttttcggg catgcgtttt ttatctttct gatgatccag 664981 tttatccgga cgattcccga ggagctggat gaagccgcgc gaatcgacgg atgcggacgc 665041 tttgcctgct tttggcggat cattctcccg ctgattgccc ccgcgcttgc gacgtctgcg 665101 attttctcct tctattggaa gtgggaggag ctgattcagc cgctcttgta tttgaataag 665161 ccggagcttt accctgtttc acttgcgctg aagctttttc tcgatacaga gtcggcttcg 665221 aactggggcg cgatgtttgc catgtcagcc gtctcgttat tgcctgtgat tcttgttttc 665281 tttttgtttc agaaatatat cgttcagggc atcagtacga ccggattaaa ataaaaagga 665341 gtgttgcaga tggcacagct tatctttgat gaagaaaagg tgacgtcggt tattgaccgg 665401 atcgtgaaac ggacatttca gatggatttt gcgtgggatt ggccgggcgg cgttgcgttt 665461 tacggtgtgg cggaggccta tgaagcgacg gaaaacgagg aatatatcaa tctgttaaaa 665521 acgtgggtgg atgaacagct ggaggatggg ctgccgccgc tttcgatcaa cggagtttcc 665581 attgggcata cgcttttgtt cctccacaag gtgacaggtg atgacgtgta tttggaaaca 665641 gcggccgaga tggcggaata tgtgctgcat aaggcgccgc gctttggcga gggtatcctt 665701 cagcatacgg tgaatgcggc agaatacgta ttccctgaac aggcatgggc ggatacgctg 665761 atgatggctg ggctgtttat gctgagaatc gggcgggtca tggagcgtga ggattatttt 665821 gaagacggcc tgcgccagtt tcacggacat gaggatgtgc ttcaggaccc tgtcacgaat 665881 ttgtactacc acgcctggga caacaaagcg caaaatcatc tgtcggggat ttattggggc 665941 agggcgaacg gctgggcggc actcacgatg gcaaaggcgc tcccgcttat tgaggtgaca 666001 catccttcct ttatgatcat cgacggatcg ctcagagacc agctgagcgc gcttgtccgg 666061 cttcaggatg aatcagggct gtggcataca attttggatg atccggattc ttatctggag 666121 gtttcggcat cagcgggtat tgcttctgct ctgatgtcga gcggaaagct gtatacaaaa 666181 tatgtgcaga aatcgcttgc cgccattttg gatgcagtgg aagaggacgg acgggtcagc 666241 agggtatcgg ccgggacagc cgtcatgaaa aatgccgaag gatacaaaca ggtgccttac 666301 aaacgaatac aaggatgggg gcagggactt gcgctgacgt ttcttgctga tgttttgaaa 666361 acgaaaaaac gcttgtatca gtaaagatag cggcgggggg agagggatga aaaaacagcc 666421 tcaacagaag gaacgggttt ctcgctggaa gggaacgtat ttcaaaagaa actttgtctt 666481 cattttgctg attgcctgta ttcccggatt gctgactggc ggcgcaatct actttctttc 666541 gatcgacaag gtggagaaag agctgcagag atcgcatgaa acacaggtgg cgcgtgaggt 666601 cagccgaatg gatgagaagc tgggagtgct tgaactggca ctcacccaga tggcctacga 666661 ttcttcactg atgaacggat tggccgagag ggatttggag aaagacttta cgttctccta 666721 tcaattaacg aaaaagctgt ttcttttgcg ggatcagcag ccgctgatcg agcaggcttc 666781 catctttctg aacagccccc ggccacttgt gctgagccct gaatacagcg ctttgacaga 666841 acaggaggcg cttcgcaagt atcgctcgct gcttgcctca gaccacagca tttattggaa 666901 acggtcggga aaccaagcga tgctgatcca gctcattccg ggcgcggcgg agaaaccgtt 666961 cggcgcgatc atgctggcgg ttgatccgaa agaaatggaa tcaatcctgc aaagcttgtc 667021 cccctatcct gatggcagtg cgttgctttt agatcaaaat cgagaggtgc tgtttcatga 667081 gggggaaaaa gattttgaaa agactttact tcatgagata aaaaaacagc ctgctgagaa 667141 cggccatttt cagatggaat ggaaaggcaa ggtgtattct gtctcctttg gagaaatgaa 667201 ccggatgcat cagcaatgga cctttgtgtc agcggcgcct ctttcagcta ttacagcgcc 667261 gatggtgttt ttatcaaaag tgatcatcgt gatgctggtc atttgcatcg gtttggcggt 667321 gtgcatgaca tggtatgcat caaaaaaaat ctatcgtccc atccagcatt tgcttggctt 667381 gtttaccgga ggagagaaga aaacatggca ggcgtccggg caggatgaat tcaaatggat 667441 tgaaaagaga tggcaggatc tatcccttga aagccggaag ctccaacagc agctcctgcg 667501 gcagacgccc catatgaaaa agagtttttt gcagcatctc ttacagagcg atttttacta 667561 tgacaacgag gaaagcctca gatttcggat ggaggaggct ggctggaaca tcggcggaaa 667621 cgtgtttcat gtgcttgatc tacaggtgac agggctccgc tgtgaaaaaa gcatcttccg 667681 tgaaggtgat gaacagcttg ccgtgtttac actgactaat atcgctgagg aattggcggc 667741 taaacgcgtt tttcagctct ccatacttga tatcggccgg ctttctgtca ccgttcttgt 667801 gatgaaaaca aacagctctg atctgaaggc gtatataacg gagctggcac gccaatttgg 667861 agatgtaacc ggactatgcc tgacctcgac attgagcagc aagacggagc gtgtcacgga 667921 aattccttct ttatttcagg atgtgaaatg cggcaaatcc cgcaggaagt ttgctaaccg 667981 ggatcaggtc attgatttgc aggccgactt ccctcgggat gagcagttcg ctccttatta 668041 cccttttgag ctggaaaaac aaattgttca gaccatccgg ctggaaagaa aacaggaagc 668101 caaggaactg atagatggat gtatgaagga actgtcggaa aaagcggcca tagacaggca 668161 tgtgcattcc gccctgattc agctgttttc ccgcattcag gaggatattt tgcattccgg 668221 gctcaatccc agcgaactgt ttcagcaccg gaatccgttt cttgatattt cagaattgcg 668281 cgaacctaac gaagcggcgg cctggctgat ggatgtagtg gtgacgcctt acctttccaa 668341 gcttgagggc agaaaaaaca gacagcaaaa gcagctggca gaacgtgtga ttgcgatgat 668401 tcacgaacag tatatggcgg acatttcatt ggaaagctgt gccgatgcgc ttggcatgaa 668461 ttcctatacg ttaagcaagg catttaagca agtgaccggc attaatttta tcgattatgt 668521 gacccagatc agaatcgaaa aggcgaaaga actgctggtc aatacgaata aaaaaattca 668581 tgatgtgtct gaagaagtcg gctatcgcca caattatttc aatcggattt ttaaaaaaca 668641 ggtcggcatg ccgccgggtg tcttcaggca aatgtatcag gaaacgccgt gaaaggagag 668701 aacatgtgat gaagaaaccg attcaagtat ttttagcggg ggattccact gtgagtgact 668761 gcccgcctca tgaagcgccg atggcggggt gggggcaggt attcgggcaa ttgttttctg 668821 aaggtgtgct ggtccgcaat catgccaaag gaggagcgag caccaattct tttgtggagg 668881 aaggaaggct tcaagcaatt gccgagcaca tcacacaagg cgattatttg ttgattcaat 668941 tcggccacaa tgaccaaaaa ccgcggggga cgaagccgta ctccacattt cagcagtttc 669001 ttaccttgtt tgcagatacg gcacgcgaaa agggcgcgca tcctgtgttc gtcacatcgg 669061 tgcagcgccg ccgctttgat gaaaacggac ggatcgagca tacgctcggt gagtatcccg 669121 atgcgatgaa agcactggcg aaggagctcg atgtacctgt gattgatctg cttgcgaaaa 669181 caaaggtgct gtatgaagca tacgggccgg aggagtcgaa gcgattgttc gtttggtttc 669241 agccgaatga acatccgaat tacccggacg gcattgagga caatacgcat ttttcggaaa 669301 aaggtgcaat ggaggttgcg aagcttgtgg cagaaggcat tgaagagctc ggacttccgc 669361 ttaaggacca ccttgtgagc cgggagggaa aagaacatgt ataaggaagg cgcttgcttg 669421 taccgcaatc cgctccggtc taaaagcgat gtgaaggatt ggcggatgga gggaggcgga 669481 cagatctcat ttgacgatca cagcttgcac ctgtcacatg tccaggatga agcgcacttt 669541 gtcttttggt gtccggaaac ctttccagac ggcatcattg tgacatggga cttctctccg 669601 atcgagcagc ctggactgtg tatgctgttt tttgccgctg cgggtattcg cggcgaggat 669661 ttgtttgacc caagtctcag gaaaagaaca ggaacatacc ctgagtatca ttcaggagat 669721 atcaatgccc tccacctgtc gtatttccgc agaaaatacg cggaggaaag agcgttccgc 669781 acctgcaatt taagaaaaag ccgcggtttc catctcgccg caatgggggc cgatccgctg 669841 ccttctccag acgacgctga ttctccgtat cgtatgaagc tgatcaaaga caaaggctat 669901 gtgcactttt caatcaatgg tctgcccatt cttgagtgga tggacgacgg cagcacatat 669961 gggcctgtgt taacaaaagg aaaaatcggg ttccggcaga tggcccccat gaaagccgtt 670021 tacagggatt ttgccgtgca tcaagcggtg agaagatgaa gacgactgta acggatgcgc 670081 tttatgcagg ctgcgaagcg gtggtgaaaa tagcatggct caacgggctg tggctgttgt 670141 ttacactttt gggcggcgtt cttttcggat gggcgccgag cacagctgcg atgtgtgccg 670201 ttataaggaa atggctgatg gggcaaaagg atgtcccgat attttcgtta tttctcgata 670261 cctataaaaa agagtttctc aaggttaatg cgatcggatt ggcgttttcg gctcttttgc 670321 tcatattgtc tgccaactat cattattttt ctgccagtac gaattggctg tcctttgccg 670381 taacaagctg cacgctgctt gcagggcttt tgtatatcat cgcgctgatg tatgtgtttc 670441 ccctttatgt gcattaccag ctcccgcttc gcaaatatat tccgcaggca ctgctgtttg 670501 gcgccatgag accgctgaca actggctgta tgctgatcgg gtgcggattt gtcctttatt 670561 tgctgtatac gcttcctggc ctgatcccat tttacggccc gtgtttattt gggcttgtgt 670621 tgatgttttt tgctcttagg ggatttcaaa agacggaggc ccagcaccat caagccgggt 670681 aacaaaaaaa tgacaaataa gcaaaaaagt gcagtgtccg aaataggcag atgcaaaaaa 670741 gtgaaattga agacagctca caaagcgcat aaaatccaat ttaagtaagc gcttacagat 670801 aaatgagaag gagctgtctg atgattagac gaaggaaacg catgtttacc gctgttacgt 670861 tgctggtctt gttggtgatg ggaacctctg tatgtcctgt gaaagctgaa ggggcagcgc 670921 ggcagatgga agcgctgaac cgggggcttg tagcggtcaa gacggacggg ggcatttttg 670981 tcagctggcg gtttcttgga accgaaaacg catctgtttt gttcaatgtg tacagagacg 671041 ggcaaaaact gaatgctgcg cctgtcaaaa caacgaacta tgtggataaa aacggttcgg 671101 cgggctcaac gtatacggtt cgggctgttg taaacggtac cgaacagccg gcttctgaaa 671161 aagcctccgt atgggcgcag ccgtatcatt ccgtcccgct ggataaaccg gctggcggca 671221 cgacgccaaa gggtgaatct tacacgtaca gcgctaatga cgcaagtgtt ggcgatgtgg 671281 atggtgacgg gcaatacgag ctgatcctga aatgggaccc gtccaactca aaagacaatt 671341 cacaggatgg ctatacgggt gacgtgctga ttgacgcgta taaactggac ggcacaaagt 671401 tatggcggat caatctcggc aaaaacatca gagcgggcgc gcactacacc cagtttatgg 671461 tgtatgacct tgatggtgac ggaaaagcag aagtggcaat gaaaacggca gacgggacaa 671521 aagacggcac gggcaaagta attggaaatg ccaatgcaga ttacagaaat gaacaggggc 671581 gtgtgctttc aggccctgaa tatctcactg tgtttcaagg ttcaaccggg aaagagcttg 671641 tcaccgcaaa ttttgaaccg gcgcgcggca atgtgtcgga ttggggagac agctacggca 671701 accgtgttga ccgttttctc gccggcattg cctaccttga tggacagcgg ccgagcctga 671761 tcatgaccag agggtattac gctaaaacca tgctagttgc ctataacttc agggacggaa 671821 agctgtcaaa gctttggacg ctggactcct caaagtcagg aaatgaagcg tttgccggac 671881 aggggaatca caacctgagc atcgcggacg ttgacgggga tggaaaagat gagattattt 671941 tcggctcaat ggctgttgat catgacggga aaggcatgta ctcgaccggc ttaggccatg 672001 gggatgccct ccatacagga gatcttgatc cgggccggcc ggggcttgag gtgtttcaag 672061 ttcatgagga caaaaatgca aaatacggct tatctttccg ggatgctgca actggaaaaa 672121 tcctttgggg cgtttatgcc ggcaaggatg taggccgggg aatggctgct gatattgacc 672181 cgcgttatcc gggacaggag gtgtgggcaa acggttctct ctactcagcg aaaggggtca 672241 aaatcggaag cggggttccg tcctcgacca acttcggcat ctggtgggac ggcgatctgc 672301 tccgggaaca gctggacagc aaccgaattg ataagtggga ttatcaaaac ggcgtatcga 672361 aaaatatgct gactgcatca ggcgcagcgg ctaacaacgg cacaaaagca acaccaacgc 672421 ttcaggctga tctgctcggt gactggcgcg aggaagtggt gtggagaacg gaggacagca 672481 gtgctctgcg catttacacg acgaccattc cgactgagca caggctgtat acgctgatgc 672541 acgatccggt gtaccggctt ggcatcgcct ggcaaaatat cgcctataac cagccgccgc 672601 acacaagctt ctttttagga gacggcatgg cggaacagcc aaaaccaaat atgtatacgc 672661 cttaactgaa agggggaagg aacgggctgc gcgcagcccg ttcccatcaa atgaaaccaa 672721 aaaagaggca aatggaatac ctgaccagag gtttgattgc ggtacagaca gaacagggcg 672781 tgtttgtcag ctggcgtttt ctcggcacgg atcatgagac gacggctttt cacctttatc 672841 gggatggaaa gcggatcacc cgcgatccaa tcgctgaaag cactaatttt ctcgatcaaa 672901 acggaacggc tgactctgtt tatcaagtgg cggctgtcaa taaaggacgg gaagaaaagc 672961 tttccaagaa agctcgtgtt tggcaggaaa atgtcctgga ggttcctctt gccaaaccgg 673021 aaggcggtgt gacgccggac ggaaagccgt acacttacag cgccaatgat gccagtgtcg 673081 gggatataga cggggatgga gaatatgaaa tgatcctgaa gtgggacccg tccaattcaa 673141 aagacaacgc tcatgacggt tataccgggg aggtgctcat agatgcctat aaactggacg 673201 gcaccttttt gtggcgcatc aacctcggca gaaacatcag agcgggtgct cattacacgc 673261 aatttatggt gtatgacctt gacggtgacg gaaaagcaga aatcgccatg aaaacagctg 673321 acggcacaac agacgggaaa ggacatatca tcggtgatga gcaggccgat tttagaaacg 673381 aacagggcag aattttgtcc ggtccggaat atttgaccgt gtttaaagga gaaaccggtg 673441 aggcgctcac gaccgtggaa tatgaaccgc cccgcggcaa gctggaggat tggggagacg 673501 gctatggaaa ccggatggac cgttttctcg ccgggaccgc ttatttggat ggggagcggc 673561 cgagccttgt tatggcgcgc ggctactata cgagaaccgt gctcgtggca tacgatttca 673621 gaaacggaag gctcaaaaaa cgatgggtat ttgactccaa ccagccggga catgaagcat 673681 acgcaggaca ggggaaccac agcttgagcg tggcggacgt cgacggagac ggaaaggatg 673741 aaatcatata cggcgcaatg gctgtcgatc atgacggaac cggcctgtac tcaacgggcc 673801 tcgggcacgg agacgcgatg catgtagggg atctggaccc gtcacgaaaa gggcttgaag 673861 tgttccaggt gcatgaggac gccacgaagc cgtacggact gtcgctgcga gatgccggaa 673921 ccggtgagat attatggggc gtccatgctg gaactgacgt tggccggggc atggcggctc 673981 atattgatcc aagctacaaa ggatcgctcg tctggggaat tgatccgccg ggcaatgatg 674041 gcatgtcgta cgggcttttc acgagcaaag gcgaaaaaat cagcgacaaa gcgccctctt 674101 cagccaattt cgccatctgg tgggacggtg atttggtcag agaactgctt gatcatgact 674161 gggacggaac gatcggcagg ccaaagattg aaaaatggga tgctgaaaac ggctgtctga 674221 agacgatatt tcagccggcc ggcgtgttgt ccaacaacgg cacgaaagga aacccggttc 674281 ttcaggccaa cctgttcgga gactggcggg aagaagtgat atggagaacg gaagacagca 674341 gcgcgctccg tatctataca acaacacatc tcacccgcca ctgcttttac acgctgatgc 674401 atgatccggt ttacaggctc ggcatcgcct ggcagaatac cgcctacaac cagccgccgc 674461 acacgagctt ttacctcgga acgggaatga aaaaaccgcc gaagcccgcc ctgtacatag 674521 cgggaagcaa agcggaggcg ccgctgtagg aggactaagg gataagacgc aaaggctgaa 674581 cgctacgcca agatgattag agaactggca ggacgaacca atgctcaagc gctgtacgca 674641 ccggtttttt caagggaaga gctatccgtg atggaagctg tataaaaaac gaggaggaat 674701 gaaaaaatgg caaatcatat ttatcttgcc ggcgattcga ctgttcaaac gtatggagac 674761 agcacaaatc aagggggctg ggggcagttt ctcggctcgc atctgccgga gcatattcaa 674821 gtgatcaaca gagcgatcgg gggaagaagc tcgaaaacat ttgtggaaga gggcaggctt 674881 caggcaatcc tcgatgtgat tgagccggat gattggctgt tcgtgcagat gggccataat 674941 gacgcgtcaa aaaataagcc ggagcgctac accgagccct atactactta taaacaatat 675001 ttaaagcagt atatcgcagg cgcgcgggaa aaaggcgccc atccgcttct cattaccccc 675061 gtagcccgct ttcattacga aaacggcgtg tttttgaacg attttcctga ttactgcatt 675121 gccatgaagc agacggccgc tgaggagaat gtccagctca ttgatctgat ggagaaaagt 675181 ctcgctttct ttactgagaa gggcgaggaa aaagtgtaca cctattttat gatttcagaa 675241 gggattaacg attacacgca ttttacaaaa aaaggcgcaa atgaaatggc gaaacttgtg 675301 gcaaaaggca taaaggagct cggcctgcca ttgacagaat cgatcatcaa agaaaggtga 675361 aaatgtgatg agaaaactgt atcatggcgc ttgctattat ccggaattat gggatgaaga 675421 gacgattcag caggacattg acatcatgcg tgaagttggc gtaaatgttg tgcggatcgg 675481 cgaatttgcc tggtcagtca tggaacctga agaaggaaaa attgacgtcg gttttttcaa 675541 agaaatcatc gcccggctgt atgatagcgg gatcgaaacg attatgtgca cgccgacgcc 675601 taccccgccg atttggttct cacatggccg gcccgaacgc atgcatgcca atgaaaaaag 675661 agagatcatg gggcatggct cccgtcagca tgcctgtacg aacaacccgt atttccgaaa 675721 aaaagccgcc atcatcacca cagccatcgc caaggagctt ggccggctcc cggggctgat 675781 cggatggcag ctagacaatg agtttaaatg ccatgttgca gaatgcatgt gtgagacatg 675841 cttgcgccta tggcatgact ggctcaaaaa tcgctacggg gtaattgagc gcttgaatga 675901 agcttgggga accgatgtgt ggagcgagac ctatcagacg tttgagcaag tcccgcagcc 675961 gggaccggcc ccgtttctgc atcatgcctc tctacgcact atgtatcagc tgttttcgat 676021 ggagatgatc gcttcgtttg cggatgaaca ggccaaaatc atccgctgct attcagatgc 676081 gccgatcacg cataacggat cagtcatgtt cagcgtggac aatgagcgaa tgtttcagaa 676141 tctcgatttt gcctcctatg acacgtacgc ttcgcaggaa aacgcctctg cctttttatt 676201 gaactgtgat ttatggagaa atctgaaaca agggcgcccg ttttggattt tggaaacgag 676261 tccgtcgtat gccgcctcgc ttgaaagctc cgcttacccg cacgcagacg ggtatttgca 676321 ggccgaagcc gtatcgtcct acgccttagg gagccagggg ttttgctact ggctatggcg 676381 acagcagcgt tcaggcagcg agatttccca cggttcggtt ctcagtgcct ggggcgaacc 676441 caccatcggc tatcaaaatg tgctggcggt tgagcgggca agaaaggaaa tcgagcctat 676501 tattctatcg actgaacccg ttcaagccga ggcggcgatg acttactctg acagagcaaa 676561 agcatttatt aaaactgagc ctcaccgggg actccggcat cgttcgcttg tgacgcattt 676621 ttatgaacgt attctcaaca cggggattca ccgtgacctt attccggaag gcgctccact 676681 ggacggctat cgcttgctgt ttacgccatt tgtgccgtat ttgtcttctg aatttatcaa 676741 aaaagcttcg gcattcgctg aagcgggcgg catctggatc accgggccgc tgacaggagg 676801 acgcacatgc gagcatacca ttcataccga ttgcggactt ggcgaacttg agaaaacgtc 676861 agggatcaaa acacttttta cctttccgat gaatgagaac gtgaatacag gaaaagcgtt 676921 tggcatcacg gcgccgctcg gactgtggag cgcggtgttt gacacagaga gcggaaacac 676981 ccttggcacg gttgaagcag gaccgggggc gggccatgct tttctgacgg aacggaatta 677041 cggcgagggg aaaattgtca tgctgggctc gcttccatcc gggaaagaag gggatgcgat 677101 gctggaagcg ctcgtcaggc attatgcgga ggaagctgtt atttccagcc ggtcggatgt 677161 gacacccggc acgatcgttg ccccgcgtat aggcgaaaac ggccttgtgt ggatcgttgt 677221 gaatatggat ggaaaaggcg ggagcgtgac attgccggaa tcgggaacgg atttgttgac 677281 gcaccgcttg gaaaaggcgg ggagactggc ggtcggaccg catgaatacc gtgtgattca 677341 atttgacaat cacagctgat tctttgtatc gaatcagctt ttttctatgg agggagagac 677401 agatgaaaaa gatcaaatgg ttatcaggac agccaaaggt gacaagcggc gtgacgtggg 677461 gcatgccatg gaaaaaagga gaattaaaaa aaggagaccg tctggcgctt atgaatgaaa 677521 acgcggaaac gcgatatgtg caaagcgaac cgtcggccta ttggccggac gggagcatca 677581 agtggacgaa gcacgcggcg gtgtttggcg gtcaggaaaa ccaaagcttt acagtgcaca 677641 aaagagaagt gccgcagcca actgaatcgc tcagcattct tgagacagag catgatatcc 677701 aagtggatac aggagcactc gtttgtacca ttcataaaac aggatctgat ttcattcaat 677761 cattgcagat caatggaaag ccgatcgccg caggcgggag gctcgttgcg ataagagaaa 677821 cgagaaaaga gtcagcggcg aaaatggttc ttttgcatga aaggtctgtc agctttatca 677881 aacgggcggc gattgagcag agtggtcctg tcaaagcagt agtcaaaatc gagggagtgc 677941 atgtgcttca taaaacgtat gaggaatggc tgccgtttgt catccgatta acgttttatg 678001 ccgggctgtc tgagatcggc cttgtgcaca cgcagctgat tgacaggagc ggtaaactag 678061 aattcgttaa ggggctcggc atcgaattcg accttttttt ggagggagag ccgtacaacc 678121 gccatttccg ctttgcggga gagaaaggga tgtataaaga acccgcccag ctgtttggca 678181 cacgtaaatt caatgaacga tatccgcttt atgaaaaaca aatcaatggc gaaatgctgt 678241 ctccagatga agagcataag gaatggtttg cacatggcac acagaatgcg gtttgggacg 678301 atgtcaagat cgtgcaagat tccagcgatc attacagcct gtcaaaacgg accggaaaag 678361 attatgcgtg ggttggaatg ctgcatggca gccgggcgaa ggggctctgc tatgcgggcg 678421 gaaaaaatgg cggtgtggct ctcggcctgc ggtatttctt tgagaaatat ccttcagcac 678481 tggaaatcac aggtcttgcc ggcagccgcc ccaaaatgac tatctggctt tggcctccgg 678541 acggcgaagc gatggatttg cggcattata caggaaacac tcacgtggcc agcgcgtatg 678601 aaggctttga tgaaatgcgc tctgatccga caggcattgc gaacacaaat gaaataagcc 678661 tggcgtgctt ttcgcacatg ccgtctgacg aagtcctcaa tgcgctggct gacaaatggc 678721 aggcgccccc gctcattgta tgcgagccgg acgtctatta cgaatcaaaa gcactcgggg 678781 tatggagcat cattgacaca tcccatccgc tcaaaaaaga gctggaagaa cagcttgatg 678841 cggcctttct gttttataaa aaggaagtag agcaacgcag atggtacggt ttttggcatt 678901 atggcgatgt catgcatacg tatgacccga tccggcatat gtggcggtac gatctcggcg 678961 gatacgcatg gcaaaacaat gagctcgttc cgaccctatg gctgtggcag gcgtttttcc 679021 gctcaggcag agaggatatc ttccgaatgg cagaagccat gacccgccat acgagtgaaa 679081 cggacagctt tcacctcggt gaatatgccg ggcttggctc acggcataat gttgtgcact 679141 ggggatgcgg ctgcaaggaa gcgagaatca gcatggccgg gcttcataaa ttctattatt 679201 atctgacggg tgatgaccgg acgggagatc ttttgacaga agtgaaggat gccgattatg 679261 cccttgtcaa aaccgatccg atgcgcgctt tttacgagaa aggcaagcac ccgactcacg 679321 ccagaacggg accggactgg gcggcgtttt gctcgaactg gctggcggaa tgggagcgga 679381 ccgaaaattc ggaatatctc aaaaaaatcg aaacgggaat caactgtctg aagcggctgc 679441 cgctccgctt attatctggc ccgacatttg aatatgatcc ggcgacctcg atgcttcatc 679501 atatgggaga cggcattgcg ggcggatatc atatgatcat tgccttcggc gcgccgcaag 679561 tgtggatgga gctggctgag cttcttgatg actgggaatg ggaggatatg ctgagtgaat 679621 tcggcgaatt ttacacactc agtgatgagg aaaaacgaaa aaaaagcgga ggcgctcttc 679681 atgacgggca ttttcactgg ccgatgttcg ccgccggtat gacagcctac gccgcaagaa 679741 aaaagcaaga tcctcatctc gccgccaaag cgtggaatct tttgctagaa gataagctca 679801 gccatacgcc gcttccgatc aaaccggagc gcatcgagac atggacgcag ctagaggagc 679861 ttccatgggt gacaacgaac actgtctctc aatggtgttt aaatgtcata gcggcgctgg 679921 aactgatcgg agattccctt ccggcaaaaa aagaaacatc gggcaaaaaa ggataacagc 679981 cggaatttca taggagaaat ggtgcaaaaa atgaagattg caagaattta tgtaagcgct 680041 ttatattgag aggggcaaag gggaaatgca aattgaaaaa agggggactt acgcaacatg 680101 aaaataagaa tgcgaaaaaa atggatggcc ttgccgcttg ctgccatgat gatcgccgga 680161 tgcagccatt cggaaacatc caattcagca agcggttcga aagatacgat caaaattatg 680221 gcgccgctct tatcgccgga aagcccaagt gataagagcc cttcattaaa agcgctcgaa 680281 aaatacacag gcaaagagat taaggtcaca tgggtgcctg attcatccta caacgacaaa 680341 ttcaacatcg tcatggcttc aggagagatg cctcacgcga ttgtcattaa agataagtca 680401 gccggcttta tcaaatctgt caaagcaggg gcgttttggg agctgtctcc ttatttaaaa 680461 gactacaaga atttaagcca ggcagatgaa aagattttga agaacagctc ggtgaacggc 680521 gaggtgtacg gaatctacag aacgagggat ctgatcaggg cgtgtatgat catcagaacc 680581 gactggctga aaaatgtcgg tctggatatg ccggaaacgc ttgatgattt ctatgaagtg 680641 ctgaaagcct ttaaggaaaa agatcctgac ggaaacggca aggatgatac gtacggcatg 680701 gtcgtgccga aatggatggg actcggcaac ggaagcccat gggatgttct gcaaatctgg 680761 ttcggcgctc cgaaccgcta cggtgttgaa aacggaaagc tgattccaga ttttacaacg 680821 aaggaataca tggatgcgct cacgtttttt aaaaagctct atgatgaggg cttgatcaat 680881 aaggactttg ctgtcatgga ttctgcgaag tggaatgatc cggttgtaaa aggaaaagcg 680941 ggtgtcatcg ttgatacagg ctcaagagcg tctcaaatcc aaagcgcgat ggaggaggcg 681001 gatgagtcga acaaggatat cattgatatc gtcggctcgc ttgagggacc gaatggcaag 681061 cgcaccttcc cgacatctgg ttattcaggc atgatcacga taccaaaatc aagcgtcaaa 681121 accgaaaaag agctgaaaga ggtgctgtcc ttcctcgata agatgaatga taaggaagcg 681181 cagattctca cgaacaacgg agtgaagggc cgcaattacg agctcaagga cggcgtattc 681241 acctcacttg aaaaaaacaa taaatctctc ctgtatgagc atgaaggctt ggcacagttc 681301 agcatgtcga ttccgaaaag cgagtattac atcgaagacc agaaaaccaa gctcttccag 681361 catcgcaagg acatcataac cgaaggagaa aaaatagccg tctttaaccc tgctgagtcg 681421 cttgtatctg atgtctatac ccaaaaagga gcccagcttg acaacatcat cctcgacgcg 681481 agaacacaat ttatcattgg agaaattgat gaaaaagggt tcgatgatgc ggtggagctt 681541 tggaaaaaaa gcggcggcaa tgaactgatg aaggacttga acaaattgta ccaatcgtca 681601 aaataaaccg atgcgcctgc ctttcggcgg gcgccccggt atcacgaaag gagaacagat 681661 atggaaacag tgccgaagaa gagagatgca cctgttctca ccgctggaaa aggcatcagc 681721 tggatggctg cgctcaaacg ggacaaatgg ctttatcttc ttcttattcc cggtctgctt 681781 tatttcttga ttttcaaata cttgccgatg tggggtgtgc tgatcgcttt taaagactat 681841 tcgccatatc tcggcttctg gaaaagcgaa tgggtcggct ttgattattt caaagacttt 681901 tttatgaatc cggatttttt ccggctgctg cgcaacaccc tcatgctggc gagtctggat 681961 cttttgtttg cctttcccgc gcctctcatt ttggctctgc ttttgaatga ggtaagaaag 682021 gccgtgtata aaagatgtat ccaaaccttt atttacgtac cccattttgt atcatggaca 682081 attgtggtca gcatcacctt cgttttcttt actgtcgata caggtgtgat caacaaattg 682141 attatgagcc tgacaggtga gcagatttct ttcttgtcgg atgcagactg gttccggcca 682201 atgattgtga tgcaaagcat ttggaaggag acaggctggg gaacgattct atttttggca 682261 gcgcttgcta cggttgatca agagcagtat gaagcggcca tcatggacgg agcggggcgg 682321 ttcaggagaa tgtggcatat tacgctgccg gcgattagaa gcaccattat cgttttgttg 682381 attttaagaa tcggcagctt tttgaatctt ggctttgaac aggtgtattt gatgacgaac 682441 tcactcaacc gcagtgtggc tgacatcttc gacacgtatg tgtacatgat ggggattacc 682501 caaggggcgt atagctacag cacggcggtc ggtttgttta aatcagttgt cgggattatc 682561 ttgatttttg gcgccaatta cattgcgaaa aagtttgatc aggaaggatt gttttagagg 682621 agggagaggt atggctgaaa ttcacacgat gcacaacacc aaagccggac gggtgtttga 682681 cgtctgcaac attctgtttc tcggcggtgt cggcgcgatt accattttgc cgtttttata 682741 tattatcgcc ggttcctttg cgacagaagc ggaactcgcc cagcggagct tctttatttt 682801 cccgaaaacc tttacacttg atgcttacaa gtatgtgttt tcgacaccga cgttccttcg 682861 aagcatgggc gtgtccatct tcatcacggt ggttgggacg gctgtacagc tgttttttac 682921 cttcacgatg gcgtatccgc tggcgaaacg gcatgtgaag ggacggaatc tgctgttgaa 682981 tctggtgatt ttctccatgc tgttttcagg cggcatgatt ccgacgtacc ttgtcgtaaa 683041 atcacttggc cttttggata cgtattgggc attgattctg ccgatggcga ttaatccgtt 683101 caaccttatt attatcaaaa acttctttca gcagctgccg cgcgagctgg aggaatcagc 683161 aaaaattgac ggctgttccg aaatcggcgt cttctggcgg atcgccctgc ctctgtcaaa 683221 gccagttatt gcgacctttg cgctgtttta tgcggtcggg atttggaatg atttcttcca 683281 cgctctctta tatatcaatg acagtgcaaa atggccgctg caaatggtgc ttcgccaagt 683341 cacaatttta tcggatttaa cggcgaccaa tggtgatacg atgcaaaatg cagttccgcc 683401 ggagcaggga attaaactcg ctgtcattgt cattgcgacg ctgccgattt tggcggtcta 683461 tccattttta caaaaacact ttgcaaaagg aatgctgatc ggttcggtga aaggctgaga 683521 aagggagtgt ttcatatcag tacattagat cagattaaga ttgcctatat cggcgggggg 683581 tcccaaggct gggccagaag cctgatgagt gatttgtcga ttgatgaacg gatgtcaggc 683641 acggtggcgc tctatgatct tgattttgaa gccgctcaga aaaatgaagt gatcggcaat 683701 cacagcggga acggcagatg gagatatgag gctgtttcta ctttgaaaaa ggcgttatca 683761 gccgcggata tcgtcattat ttccattttg ccgggatcac tggatgatat ggaagtcgat 683821 gtgcacttgc ctgagcgctg cggtatttat cagtctgtag gtgatactgt cgggcctgga 683881 gggatcatca ggggcttgcg tgctgtgccg atatttgcgg aaattgcccg ggcaataaga 683941 gactacgcac ctgaatcatg ggtcattaat tatacaaacc cgatgtctgt ctgtacaaga 684001 gtgctgtata aagtgtttcc cggcatcaaa gcgattggct gctgccacga ggtattcggg 684061 acgcaaaagc tattggcgga aatggtcacg gaaaggctgg ggattgaggt gccgcggcgt 684121 gaggatatcc gcgttaatgt gctcggcatt aaccatttta catggatcac aaaagcctct 684181 taccgccata ttgacctgtt gcctatattc cgtgaattca gcgcgcacta tggggaatca 684241 ggatatgagc tggaggggga atgctggagg gacagcgtct tttgttcggc acaccgtgtt 684301 gcgtttgatt tatttgaaac gtatggcgcc atccctgctg cgggtgacag gcatctggca 684361 gagtttcttc ccggcccata cctcaaacag cctgaagtat ggaaatttca tctcacacct 684421 atatcattca gaaaacaaga cagagctgag aaacgacaag aaacagaacg gttgatcgtg 684481 caacaacggg gcgttgctga gaaagcttcg ggagaagaag gcgtgaacat catagcggct 684541 cttctcggat tgggtgaact cgtcacaaat gtaaatatgc cgaatcaagg ccaggtctta 684601 aaccttccta tacaagccat tgtcgaaaca aacgcattca tcacaaggaa ccgtgtccag 684661 ccgattttgt ccggagcgct tccgaaaggt gtggaaatgc tggcggctag gcatatatcc 684721 aatcaggagg cagtggcgga cgcaggttta acaaaggata ctggcctcgc gtttcaagcc 684781 ttcctcaatg acccgcttgt ccagattgac cgcagtgatg cagagcagct tttcaatgac 684841 atgctccaat gcatcatgca aagctgagct tgccgattag ctctttccgg tttagaaagg 684901 aaagcattga ccatactgat agtataatca agaagtaggt gctatcaata tgggaaatta 684961 tttaagtgtt gcggtagaac tggtctgcgg tttaggcatt ttatttatca tcttaaagct 685021 tctcgggaaa acccaatttt ctcaaattac gccgtttgac tttatttctg ctttaatttt 685081 aggtgaattg gtcggaaatg ccgtctacga tcatgaaatc aaaatcaaag aaattatttt 685141 tgcttcgcta ttgtggggcg tgctgattta tattattgaa tttatcacgc aaaaaatgaa 685201 atcatcgcga aagttcttgg agggcgagcc gaatatcgtc atccgcaaag gggagcttca 685261 atataaagta atgaagaaaa ataagataga cattaaccag ctgcaaagcc tattgaggca 685321 agctgggagc ttttcgatcc aagaagtaga atatgcgatt cttgaaacaa acgggatggt 685381 cagcgtgctt ccaaaatcag actttgacaa accgacaaat aaggatttgc agattccttc 685441 gaagtccgtt tctctgccga tcacgttaat catagatgga gagattgtgc gggataattt 685501 gaaggaagca ggtgtggatg aacagtggct gaaacaagaa ttgaaaaaga agaacattga 685561 taagacagag gacgtgttat ttgcagaatg gcataaaaat aagccgctgt atactgtaac 685621 gtacgaacaa agcagatcaa catgactctt agaaaaaagc ttgcagcaag gcgcaagctt 685681 tttattgatt gtatgtccct tgtttgacag cacgtacatg gtacatgctc acttcagtgc 685741 tgatcagata gtcaggcttt ggtttgcctt tgtttgcttt atggccggcg atatgcgcat 685801 cgcttttttc ccattgcttc cagtgatcct ctgattccca gcgaatcatg acaacaactt 685861 cttcatcacc gcggcgcaca tttttctcaa gcactgtcac atcaattaaa ccttcttgtt 685921 tttcaatgat tccttcagcg ctgaaacgtt ctatgacttt atctgcaaag ccttctttaa 685981 ccgtcatttt tctcaactgt acaaacattt gtctcactcc aatcattctc acatatgaat 686041 aattgtaaat gaaattcatt ctcaatgtca aagaaagcgc agggcggaat cgaaccgccg 686101 tgcgcaacag tttattcttt taataaaaac acatttccgt cttcgtcctt aaattgaacg 686161 aaggtgcccc actccatttg attgggctca ccgagaaatt ctacaccgtt tgtcttcatt 686221 ttctcgtatg taccaaagat gtcttcgcat tcaaacacaa tagaagcctt catttgctct 686281 gagcctttca tcatggcttt cgggtaaatg actaaacgag tctcggctcc ttttggcgca 686341 acctccagcc agcttgcttc aggtcccatt gggtgatccg ctgcaatatc aaagcctacc 686401 ttctctgtcc aaaattgctt cgctttctgc tggtcctcga catatacagc aacagtgcca 686461 atttgtttga tcatagggaa acctccaagt tgaaaagata ataatactat aacctgttta 686521 cggccgaagt aacataaaaa aatcagccgg gaaaccggct gattattaaa atgagcagct 686581 tacaacatcg atgtgatttg tgtctaaggc gaaataaacc cagcggcgcc gtgaggaatc 686641 ccaataaaag ccgccgacgg atcttctgcc aaggatgatc gggtaaaacc aaaatgagcg 686701 gccattggtt aaccagacat aggtaaatcg gaaaaggcaa ggacgaatgg tgattggttc 686761 aactaacaaa acggctcctt gagaaccctg cggttttggg ggtttcgctg gtatttggga 686821 aggaggaggt ccctgcggcg caccgccgaa gcctgggctg gcaccgctgc caataccagg 686881 gccggagccg ccgccaaagc ctggaacagc accaccgcca atgccaggac cggagccgcc 686941 gccagagccc ggaacagcgc cgctgccaat gccaggccat ggatatcggt attcatattc 687001 aaaagcaggc caaggctcat aaaaatgccc cgcaaacata taaggatcaa cataatacat 687061 gtgataacgt cctttctcat tgtaaactgt acattgcagt ttatgcgggc ggactcttat 687121 tggtgcattc gcctaaggat atgaagctgg aatgctctca gagagcagaa tcatttgatt 687181 tttctctagt cttattcaca attccgattt atcattttat aatgaaagtg cttctattac 687241 gaaaaaggag acagaccgtg aatatcgatc aattattata tcaatatatc atagacaaca 687301 ctgcggatat tactgagaaa tggttcagtt tgcgttgcca gctaaaaggc gagctatatt 687361 ccgccagcca tttaagtgaa gaaacgaaaa cacttttaac cgagcagcat acatttacca 687421 atataacaat cgcaagcgca tttctggagg atcaaaccga ttttcaagaa aacatgacaa 687481 aatgggcgca aaacgttgcg aaaaacaggg tagagcagga tgttcaagtg catgaggtcg 687541 tagaagccat atccaattca agaatctcat tctgggacgc agtcgccaca tttataaaag 687601 agaatcagga gattgtgaca aatgaggatg cagaccgatg gaaccgcatt gtgaatcagt 687661 cgttcgataa gctgattatt gaattctccg agcagtacca aaaattcatg ctgatgaggc 687721 ttacatctca gcaggaactg atctcagagc ttggctgccc ggtcatttcc attgccgatg 687781 gaatcgggat attgccgctt atcggctcca ttgatacaaa acggcacagg tcattttaga 687841 aacagtgccg gtccgctgtg tcgagagaaa aatcacaagc ctcgtcgttg atctttcggg 687901 tgttccgatt gtggatacca tggtggctca gcaattgtac aacctgtcta aaacactttt 687961 cttattaggc gtcaaagccg tattttcagg aattcgcccg gatgtggccc aaacatcgat 688021 tcaattgggg cttgatttta gtgaatatga aacgtacggc acgctgaagc aggcattaga 688081 aaacatgggt gtccgctgta ttgttgagga attggaagaa aacaaatagg aagtttccag 688141 gcatatgatt gtccgtcacc gggtgatcat atgccttttt gatttgaaca gaaatcacca 688201 ttgatttatc gaaaaaaaca taatattata attcttataa gaatactgtg aattaaaacc 688261 tattcaacag gggggaaggt cttttggttt ctaaatcaac gattgatccg gaagtgattg 688321 aaaaaatcat cagctcgctg gaaacactcg atttcggcac ggttcagatt acggttcatg 688381 attctcagat tacccaaatt gagaaaatag aaaagcaccg tttttcgctg aaaaggaaag 688441 aatcaaaatg ataatgtaaa gggcgtttgt tttcattaaa ttctccttaa aacatataca 688501 tatttcatcc aatttttata taatagacct ttaagatcat tttttaggag gatttttgac 688561 atgcaagcta cggttcacga gagtaagcaa tcgatcatgc aacgcatttt gacagtcttt 688621 gtcttcacat tgctgatcgc gactgtcggc ctttttatcg gccaatttgt tcctgtcgct 688681 ttgatgctgc cgctttctat tcttgaagtg gcgatgatta ttctggcctt ctggatgcgc 688741 agaagaaaag cggtcgggta tgcgtttgta tatacattcg cgttcgtttc cggcattacc 688801 ttatttccga tcgtcagcca ttacgcttcc atcgccggcg cctatgtcgt gctcgaagcc 688861 tttggctcta catttgtcat ttttgccgtc ttgggcacaa tcggcgcaaa aatgaagaag 688921 gatttatcct tcctgtggtc gtttctgctg gttgcggtgc tcgcactcgc agtggtaggg 688981 attttcaaca ttttcagccc gttaaactca gcggcgatga tggcgtattc cgtgatcgga 689041 accatcgtct tttcccttta cattttgtat gatttgaacc aaatcaagca ccgccacatt 689101 acggaagact tgattccggt tatggcgtta tcgctgtacc tagactttat caacttgttc 689161 atcaacctgc tccgcttctt cggcattttg agcagtgatg attaatgaaa aagcgtctgt 689221 cattggatag gcgctttttg ccatacatca aaaaggcagg tggagtattg gtgaaaaaac 689281 aaatgggcgc atatgtatct ctggcagcag ctatggcgat cgtcggcagt tctgtcgttg 689341 tcggcaagct gatggtcgaa cggattccgg tctttctttc ctcaggattg cgttttttga 689401 tcgcttctgt cgtattgctc atgctgctgt tttgcattga aaaagggttt ccggctttga 689461 cgaaaaaaga tgtgttcgta ttactggtgc aatcattcac aggcgtgttt ttgttcagta 689521 tttgcctgct gtatggggtt caatatacga cgggaacgga aagcggcatt ttgacaagca 689581 caacccccat gttgatcggt attttatcct ttttcctgct gagagaaaaa attgagaaaa 689641 agacgctgat cggcattttg ctggcggttt gcggcgtaat ggcgattaat ttgtttggag 689701 ccgggagcca agacgggacg ccgcacgcct tattcgggaa catgctgatc attgctgcag 689761 tcattggcga agcgttgttt acattgatgg ccaagctgct atccccgcat atttcggcac 689821 tggcgatttc gaccttcgta tcgctcttcg gcttcctgtt ttttctcccg tttgctttgt 689881 ttgaggcctc ttcatttgat tacagcgtgc cgactgtttt ggattggtcg tatgtgctgt 689941 attacgcgct ttttgtcact gttttggcgt tttacttatg gtatagcggg gtgacgaagg 690001 tgccggcggg tgtatcgggc attttcacat ccgttcttcc ggtctcagct gtcattttgt 690061 caggcgtgat attgaaggag ccatttgagt ttgtgcattt catcggcatt gcatgtgtca 690121 tcggcggcat atttgttacg gtcataaaga aaaaacagcc ggatgcgtat ccggctgcag 690181 aagaaaagac gctatagcct gtccggatcg gacgggtttt ttagtcttta aacacgctca 690241 gcctttcaaa aagatcacca agcatcttca cgaacatgtc tttttcctcg tcgctgtagt 690301 tttccatgac agcggatatt ttgctgaaat ggccgggcag aaattgctcc aggcgtgctt 690361 tgccttctgt tgtcagttca atgctgattt ttcgtttatc ctctgtgtga tgcctgcggc 690421 tgacaaaacc gtctctcgcc agcccgtcta gcaggcctgt aattgttgct ttcgtgacat 690481 ttgaccgctt ggcaagctct gtcggactta acctatgatc cttggcatca aagagcagca 690541 tcaggatttt gaattttcct tctgaaagcc ctcggccagc aaagtaatgc tccatcacat 690601 gattcatttt ttttgaaata tcaaaaagag ataaaaacaa ttcaagagag ccggcgtcaa 690661 tattggcata cgtttcggcg tgctctgtta tatgcttata tttcggtaaa tgttttaatt 690721 ccatcgcaat tagctcccgt acattcgttg tgacacgatt ataaaggagg gaaaaccata 690781 acgcaacttg gcttggagat gattgacagc ttttcttggg acatagtaag gtaatatagt 690841 taggcgccta actaatacat atagagctga aaaggtggtt attgatatga aacatatgtt 690901 aatagcagga ggcggaatcg gcggcttgtc agcggccatt tctctccgta aggcagggtt 690961 ttccgtcacc ttatgtgaag cggcttcaga aaatcgaaaa acaggtgcgg ggattcttca 691021 gccgcaaaac gcactggcgg tgttgaaaga actgggcgta ttcgaagatt gctgtaagca 691081 cggctttcaa acagaatggt ttaaaacgtt tgatgaacag gggaatttgc tgtttcaagt 691141 cagtgaatcc tttttagacg attcacttcc gggacgcaat aatatcctgc gcaaaacgtt 691201 aaatgacatt ctcatgaagc atgccgaggc agtgggtgta gacatcaagt gggggaaaaa 691261 ggttgtcgcc tatgaagaaa ctgctgaatc ggtcactgcc ttatgtgaag atggagaaaa 691321 gatgcaggct gacattctgg cgggctttga cggcattcac tccgttgttc gtgataagat 691381 gctgcaaaag gaaacggaaa aagagcatct cggcatggga gcgtggcgct tttatatcga 691441 acttcctgat tacacattcg aggacgcaac attcatgtat agaagcggag acacacaaat 691501 cggggtggtg ccattggcac aacacgctgg ctatgtcttc gtcctccagc cttgcacgag 691561 cgattactgg gatgaggaag atacccggtt tgatagagta aaagagattc tttctggttt 691621 tcgggggctg gattttgtca caaagcacat gtcaaaacag catcctgtca tctttaacaa 691681 actggagcag gtcgccgtgc aggagccatg gcataaaggc cgcgtcatca tcggaggaga 691741 cgccgcccac gccggtgcgc caaccctggc acaaggagcg gcaatggcga tcgaggatgc 691801 catcgtcctc gccgaagaac tccaaaacca cgccgaccac gaaacagcat tacaggcgta 691861 ctataaaaga agagccccac gagcgctcaa agtccagaac ctatcatctg aaatcgtccg 691921 ccgcaggctg aaaggagagc cgggagcgga agaactgatt ggggagtgct atgcggtgtt 691981 gagggaaggg tattaaatag gaaaagtcca gaaagtgatt tctggacttt ttagtcttgc 692041 tctgttttat tccttatccg ctcaatcacc tcatgcagcc cctcaggctt ataaaactcc 692101 accggtgaac tgcctttctc aaacgaaatc gtctcggctt caatcagcgc gacatagcgc 692161 ccgtttactt ttgcgagatg aatagaatcg ccaaaatccg ctagcaatcc cttaatctct 692221 gtttctccga ctttcatttt cagctgggcc tctggcgtgt gctcgatgat ttgggcggag 692281 gcttcgatga cttgatgggt gtcgaggcgc tcttggattt cccgtttttc gcttgcttcc 692341 caaatctcaa tgtcgtgctc gaactgcttg agttcttcgc tgttgtcttc aaatgtctcg 692401 tagacgtgct cttgtaccat gttcatgacc tgatttttca tgatttctgg catcgattct 692461 ccgtactcga cgaatttcag aaagtcctca aaatagcggg cgtgcgaggc ctggtggatt 692521 ttcagttcac cttcctcgac cattccttcc tctggcatgt acgggtattg gatgcttttc 692581 atgttttttg tcgtgatcgc catttcgact tttttaatga gagaagacgc gtcagagatg 692641 cgggcgacct tcggctcaaa atcacatttc ataatgaaga caaatgactc atcaaagtat 692701 tttctcggca cggccgaagc gacgagaaac acgccgccgc gaaccgcgct tgtgtcaagg 692761 tacgtgcgga cgaactgctc gctcagctca ttgaagtctt cttttgtttc cgccagacgc 692821 gcgcggttga acatgttgta gtttgggttg gaatcgagct cgtggccggg ctcgacgata 692881 aaatggccga ttttcgtcgg cacctgctcg gactgcggat ggcggtcggc tttccgttta 692941 acgatttttt tcagttcccc gtcgagaaag tccttcagct cgctttcttc aaattctccc 693001 gtatcaaggg tctggaagtg cttgaactgc ttgttcgcct gctcatcttt gccttccacc 693061 tgtatgacat aaaaggataa aaaccgaatt tcaaaatcca tatataaact caccttattc 693121 gcgtattgta cagcttctca agtatagaaa aaacagcgat catgcgtcaa ttgggagaac 693181 ggaataatca tgaccatgaa agggaaatgt agtcaaatag aaggcatttc atacggaaag 693241 gaatggttcg atgaaggaaa caagcccgat tcctcagccg aagacgtttg ggccgctcgg 693301 caatttgcct ttaattgata aagacaaacc gacgctttcg ctgatcaaac tggcggaaga 693361 acagggcccg atttttcaaa tccatacacc cgcgggcacg accattgtag tgtccggcca 693421 tgaattggtg aaagaggttt gtgatgaaga acggtttgat aaaagcattg aaggcgcctt 693481 ggaaaaggtt cgcgcatttt ccggtgacgg attgtttacg agctggacgc atgagcctaa 693541 ctggagaaaa gcgcacaaca ttctgatgcc gacgttcagc cagcgggcca tgaaggacta 693601 tcatgagaaa atggtcgata tcgctgttca gctcattcaa aaatgggcaa ggctcaaccc 693661 gaatgaagca gtcgatgtcc cgggagatat gacccggctg acgctcgaca ccattgggct 693721 atgcgggttt aactaccgct ttaacagtta ctacagagaa acgccccacc cgtttatcaa 693781 cagcatggtg cgggcgcttg atgaagcgat gcatcaaatg cagcggcttg atgttcaaga 693841 taagcttatg gtcagaacaa agcggcaatt ccgctatgat attcaaacga tgttttcgtt 693901 agtcgacagc attattgcag agcgcagggc gaatggagac caggatgaaa aagatttgct 693961 cgcccgcatg ctgaatgtgg aagatccgga aactggtgaa aagctcgacg acgaaaatat 694021 ccgctttcag atcatcacgt ttttgattgc cggccatgaa acaacgagcg gcctgctttc 694081 ctttgcgact tactttttat tgaagcatcc tgacaaactg aaaaaggcgt atgaagaggt 694141 cgatcgggtg ctgacggatg cagcgccgac ctataaacaa gtgctggagc ttacatacat 694201 acggatgatt ttaaatgaat cactgcgctt atggccgaca gctccggctt tcagccttta 694261 tccaaaagaa gacacagtca ttggcggaaa atttccgatc acgacgaatg acagaatttc 694321 tgtgctgatt ccgcagcttc atcgtgatcg agacgcttgg ggaaaggacg cagaagaatt 694381 ccggccggaa cggtttgagc atcaggacca agtgcctcat catgcgtaca aaccattcgg 694441 aaatggacaa cgggcctgta tcggcatgca gtttgccctt catgaagcca cacttgtgtt 694501 aggcatgatt ctaaaatatt tcacattgat tgatcatgag aattatgagc ttgatatcaa 694561 acaaacctta acacttaagc cgggcgattt tcacatcagt gttcaaagcc gtcatcagga 694621 agccattcat gcagacgtcc aggcagctga aaaagccgcg cctgatgagc aaaaggagaa 694681 aacggaagca aagggtgcat cggtcatcgg tcttaacaac cgcccgcttc tcgtgctgta 694741 cggctcagat accggcaccg cagaaggcgt cgcccgggag cttgctgata ctgccagtct 694801 tcacggcgta aggacaaaga cagcacctct gaacgaccgg attggaaagc tgccgaaaga 694861 gggagcggtt gtcattgtga cctcgtctta taatggaaag ccgccaagca atgccggaca 694921 attcgtgcag tggcttcaag aaatcaaacc gggtgagctt gagggcgtcc attacgcggt 694981 atttggctgc ggcgaccaca actgggcgag cacgtatcaa tacgtgccga gattcattga 695041 tgagcagctt gcggagaaag gcgcgactcg gttttctgcg cgcggggaag gggatgtgag 695101 cggtgatttt gaagggcagc ttgacgagtg gaaaaaaagc atgtgggcgg atgccatcaa 695161 agcattcgga cttgagctta atgaaaacgc tgataaggaa cgaagcacgc tgagccttca 695221 gtttgtcaga gggctgggcg agtctccgct cgctagatcg tacgaagcct ctcacgcatc 695281 cattgccgaa aatcgtgaac tccagtccgc agacagcgat cgaagcactc gccatatcga 695341 aattgcattg ccgccggatg ttgaatatca agagggcgac catcttggcg tattgccaaa 695401 aaacagccaa accaatgtca gccggattct tcacagattc ggtctgaagg gaaccgacca 695461 agtgacattg tcggcaagcg gccgcagtgc ggggcatctg ccattgggcc gtcctgtcag 695521 cctgcatgat cttctcagct acagcgtcga ggtgcaggaa gcagccacaa gagcgcaaat 695581 acgtgaactg gcgtcattta cagtgtgtcc gccgcatagg cgcgaattag aagaactgtc 695641 agcagagggt gtttatcagg agcaaatatt gaaaaaacga atttccatgc tggatctgct 695701 tgaaaagtat gaagcgtgtg acatgccgtt tgaacgattt ttagagcttt tacggccgtt 695761 aaaaccgaga tactattcga tttcaagctc tccaagagtg aatccgcggc aagcatcgat 695821 cacagtcggt gtcgtgcgcg gcccggcgtg gagcggccgt ggcgaataca ggggtgtggc 695881 atcaaatgat ttagctgagc gtcaagccgg tgatgatgtc gtgatgttta tccgcacacc 695941 ggaatcccgg tttcagcttc cgaaagaccc tgaaacgcca attattatgg tcgggccagg 696001 cacgggagtc gcgccatttc gcggtttcct tcaagcccgc gatgttttaa agcgggaggg 696061 caaaacgctc ggtgaggctc atctctattt tggatgcagg aacgatcggg attttattta 696121 ccgagatgag cttgagcggt ttgaaaaaga cggaatcgtc actgtccaca cagccttttc 696181 ccgaaaagag ggcatgccga aaacatatgt ccagcatctc atggctgacc aagcagatac 696241 attaatatca atccttgacc gcggtggcag gctttatgta tgcggtgatg gcagcaaaat 696301 ggccccggat gtggaggcgg cacttcaaaa agcgtatcag gctgtccatg gaaccgggga 696361 acaagaagcg caaaactggc tgagacatct gcaggatacc ggtatgtacg ctaaggatgt 696421 ctgggcaggg atatagataa agaagactgg agacatccag tctttttagt cctttcgaaa 696481 aaatggtgat cgcgctaaac attgatgcat acaataactt cagtccgccg gaagggcggg 696541 ctgtctgcaa aacctatttt tcgtttttgc tagtttatgt tattcttata ctcggtatct 696601 atttcttttt tcaaaggcac acatgacaaa agaaatcctt tttttatttc cgagaaaaaa 696661 atgtgaaacg aaatgaaggt ttctttcgtc cagtgattgg tttccaaatg gttgtaataa 696721 aaatgatatg gtgcgaaaca taaatattcc ggcttgccgc ggtgtattta ttgttgtgtg 696781 atgccttgat tttgtttgga aagaaggaat tggaaggcag gatataaaga gcaggtaaat 696841 atgaatgaag aacttaaagt gtttaagaaa gtagaggttg ccatgaagaa acttttttct 696901 tacaaactta gcttttttgt gctggctgtt atactgtttt gggcaaaaac gtatttatcc 696961 tacaagactg agtttaatct tggggtaaaa ggcacaactc aggagatcct cctgatattt 697021 aacccattct caagcgccgt cttcttttta ggactggctt tgctggcgaa agggcgtaaa 697081 tcagccatta ttatgctgat tatcgatttc ttgatgacat ttgtgttata tgcaaatatt 697141 ttattctatc gtttctttga cgatttcttg acgttcccga acattaaaca gtccggaaac 697201 gttggaaaca tgggagacgg gattttcagt atcatggccg gtcatgatat tttctatttc 697261 ttagatatta tcattttgat tgcggtattg atctggagac ctgaattaaa agaatacaaa 697321 atgaaaaaac gctttgcatc tttagtgatc ctttctggga tcgcactgtt tttcatcaac 697381 ctgcactatg cggaaaaaga ccgtccgcaa ctgctgacaa gaacgtttga ccgcaattat 697441 attgtgaaat atttaggttt atacaactac accatttatg acggtgtaca gacggctcaa 697501 acagagacgc aaagagccta tgcaagcagc gatgatttaa caagtgtcga gaattacacg 697561 acgtctcatt atgcgaaacc aaacgccgag tacttcggct ctgccaaagg caaaaatatc 697621 attaaaattc acctcgaaag cttccagtca ttcctgattg actacaagct aaacggtgaa 697681 gaggtgacgc ctttcttaaa taaacttgcg cacggcgggg aagatgtgac gtattttgat 697741 aacttcttcc atcagacagg ccagggaaaa acatctgatg ccgagctgac aatggataac 697801 tcgatcttcg gtcttcctga aggctccgcg tttgtgacga aaggcgaaaa cacctaccag 697861 tcgcttcctg cgattttaga ccagaaggaa ggctatacaa gcgccgtcct gcatggtgat 697921 tacaaatcgt tctggaaccg tgaccagatt tacaaacata tcggatatga caagttcttc 697981 gacgcaagca cgtatgatat gtcagatgaa aatgtgatta atatggggct taaggataag 698041 ccgttcttta cagaatcgat tccaaagctt gaatctctta aacagccatt ttatgcgcat 698101 ttgattacat tgacaaacca ttatccgttt aaccttgatg aaaaagacgc gtctcttaaa 698161 aaagcgacaa caggcgataa cacagttgac agctacttcc agacagcgcg ttaccttgac 698221 gaagcgcttg agcaattctt caaggagctg aaggaagccg gcctgtatga caactcagtc 698281 atcatgattt acggtgacca taacggtatt tctgaaaacc ataaccgagc gatgaaagag 698341 attcttggaa aagagatcac agattatcaa aacgcacaga accagcgtgt gccgctgatg 698401 atccgcgttc ctggcaaaaa aggcggagtg aaccatacgt atggcggcga aattgacgtc 698461 atgccgacac ttctgcactt agaaggaatt gattctcaga aatatatcaa ctttggtact 698521 gatttattct ctaaagacca cgacgatacg gtggcattca gaaacggaga cttcgtaacg 698581 ccgaagtaca catcagtcga caatatcatt tacgatacga agacaggtga aaaactgaaa 698641 gcgaatgaag aaacgaagaa tctgaaaaca agagtgaacc agcagctgag cctttcagac 698701 agtgtcctgt acaaagactt gctgaggttc cataaactaa atgatttcaa agccgttgat 698761 ccgtcagact atcattacgg caaggagaaa gaaatcaaat aagatgaaaa agagccttga 698821 gcgggcgcat tgccttcgct caaggctctt tttttggtta tacaaccaac ttgaaaaaat 698881 agattccatt tggtcaccaa ggctggcttt ctctcatatc attacagtag attttgaaac 698941 cggattgaaa tcggacaaat tatcggggaa atgccttgat agattgtgaa gatgtaccag 699001 gtttcgaact caatattcat agagatgagg ggtagagatg aaagcggtca ttctctgcgg 699061 cggaaaagga acgagaatga gtgaagtcac gaatgacatt cctaaaccgc tcgccatgat 699121 aggcggcaaa ccgattctat ggcatattat gaaaatttat cagtactacg gagtaaacga 699181 gtttattctg cttttgggct ataaaggaga aaaaatcaag gaatactttc tcgactatga 699241 atggaagcac aacagcctga cactcgacag ctctacggga gaggtacaga tgctggggca 699301 gcctgaaacg tggaaaatta cgtttttgga gactggggta gatacgctga cagccggaag 699361 aatcttgcag gcgaaagact atatcggtga tgaaacattt ctgctcacct atggagacgg 699421 gctggccaat atcaatcttt tccatctcat cagctatcat cagacaaaag gtgctgccgc 699481 gactgtcacc ggcattgaca aagtctcgca gtttggcacc ttgacagttg aggatggcat 699541 ggcgaaaaca ttttctgaga agacatcaag tgatggaatc atcaacggcg gattcttcgt 699601 tcttagtcca aaggttttcg attatttgcc gaaggacggg aacacgatgt tcgaagatga 699661 accgctgaag aaccttgcca aagatgggga gcttgctgtg taccgccatt acggattttg 699721 gacggccatc gatacgtata aaaatctctt agaagtcaac aaaatgtgga atcaaggaca 699781 acaagtatgg aaggtatggt gaattgattt gagtttctgg aaaaataaaa acgtatttgt 699841 cacgggatgc acaggtcttt taggaagcta tttggtgaaa gagctgatcg aacagggcgc 699901 aaacgttacg gggctagtca gggatcatgt gcctcaatcc aatctttatc agggagaaca 699961 tatcaagaaa atgaacatcg tgcggggctc tcttgaggac ttggctgtga ttgaacgcgc 700021 gcttggcgag tatgagatcg acacagtctt tcatcttgct gcacaagcga ttgtcggcgt 700081 ggcaaaccgc aacccgattt ctacctttga agcgaatatc ctcggcacct ggaatattct 700141 cgaagcctgc cgcaagcatc cgttaattaa gcgggtcatt gtcgcttcaa gtgataaagc 700201 ttacggcgat caagaaaacc ttccatacga tgaaaacatg ccgctgcaag gcaagcaccc 700261 gtacgacgtc tcaaaaagct gcgcagatct gatcagccac acctattttc acacgtacgg 700321 gcttccggtc tgcattacgc gctgcggaaa cttatacggc ggcggagatt tgaacttcaa 700381 ccgcatcatt cctcagacga ttcagcttgt gctgaacggg gaagcgccgg aaatccgaag 700441 cgacggcaca tttgtacggg actacttcta tattgaagac gccgttcagg cttatctgct 700501 tcttgcagaa aaaatggaag aaaacaatct tgccggagag gcctttaact tcagcaatga 700561 gatccagctg accgtacttg aactggtaga gaaaatatta aagaaaatga acagtaatct 700621 gaaacctaag gtgctgaatc agggaagcaa tgaaatcaaa catcaatatt tatccgcgga 700681 aaaagcaaga aagctgctga attggacacc ggcctacact attgatgagg gacttgaaaa 700741 aacgattgag tggtatacgg aattcttcaa aaagtaatgt gaaacgaggt gaacaagact 700801 gtgaccagcg cgtattgcac cgttttatca aaaggaagat tatatcaggc agtcgctttg 700861 tttaagtcgt tagagcaagt tgatcaagac agtcccattt ttatactttg catggatgaa 700921 gatacgcacc gcgtgttaca gaagctgaag atgaagcagc tgaaccttgt gccggtggcc 700981 gctcttgaaa atgaattgct gctgaagctg aaggaaacta gagatcaaag tgagtattgc 701041 tggacgatga agccgatctt tctgcaagct gtgctgaaca gcaatcctga gctggagcgt 701101 gtgacgtata ttgacgggga tctctttttc tatgcagatc catcgccgat ttttgaaaac 701161 cagccggact gctcggtgtt gctttcacga ggggatattg taatcccttc ttttgagaaa 701221 gagcagattg acatgctgca gcgtctttta ggcagatata attccgggtt tatcagcttc 701281 aagcatgatg atgcaggcac ggattgcttg gagtggtgga aggaacgctg tcttgaggaa 701341 tgcaaaaatg caccgggtga agggaaattc ggtgatcagg gctatttgga ttatatgtct 701401 gagctgtttc cgaatgtgtg tgacattaca acacccggcg tgaacatcgg ccattggaat 701461 tatggacagc atacgttttc ctggaaagat ggccggatcg tgctggagga tggcagtccg 701521 ctgatctttt atcatttcag cggataccga atcgtcagca tcaatgaaat caaacagatt 701581 catgaaacaa cccgcacaga tctgccgttt gtgcatgaac tgtatcaaga gacactgccg 701641 catatcattc agcacatgca aacgttagac cctgaattta acggttttgc ttcaaaagat 701701 gacaacaaat aaatgagtaa atacaggaag tgaaaatgaa gtgaaagcaa gcgttattat 701761 tcctgcatat aattcgaagg agcgtcttta caacagcctt ctgtcattaa accagcagga 701821 gtgcgatgaa gaatttgaag tcattgtagc ggacaatggc tctgaggacg ggacgctctc 701881 gatgcttgag tcatttcaag ctgattttcc gctgatcttt acacggatta aagaaaacag 701941 gggcattgcg tacggacgaa atcaggcgct tcgcaatgcc agaggagaca tcctgatttt 702001 ccatgacagc gatatgcttg cggcaaagga ccttgtggca aaacatatta aagcccatga 702061 gaacgaagag aatctcgtcg tgtgcgggtt gttttggaaa cggatctaca gtttttacta 702121 tgaacgattt gaagaagaac ataaggaaca gctcgcaaag ctcacaggtg aaatgccgaa 702181 gaaagacaaa caaaagctgc tggaggaagc ggacatcaaa aacggaagct ttcttgataa 702241 aagctttgac ctcgataccg actttataga cgtgctcaag aagattttag atgagtacgg 702301 cgatgacttg aaaggctatc atatgccatg gcgctttttt atcacgaata attcctctgt 702361 gaaacgcaag catgtggttg acctcggttt atttgacgaa ggcattgtgc ggtacgggtt 702421 tgaggattat gacctcggga tcaggcttca tcaggccgga ttgaccttca ggcttcgccg 702481 tgatattgtc agtgttcatc aggaacatcc aagcaattgt aagtctgtag acgatattcg 702541 ggcaaacatt gcctatatgt gcgataaata caataacatc cgctccttag acgttcatct 702601 cgcttttaat gggccgttcc cgcctgacat gacgaacaga atcatggctg atattcaaaa 702661 gctgctggaa tcacagaaat atgatatgct gctgaatctg tttcttgagc ttctgcatgt 702721 tgttaaagag cgcaacattg atccggattg gcgaaagaaa tccccaaggg tgacggcgaa 702781 aagctttgat ttgcaaactg tccgcaagct tctgcctaag gcgaagaaaa agctaggcgt 702841 gaacgatttt gccaacgcac tgtatgcgct tgtcaacgat ttgctgcacg tggatcttag 702901 atcattggat gtggtataag tgagtacatt tcatttttca acgatagtgt caaggacaca 702961 tatctttaag ctcatgccta tgattcattc tctccatgag cattgcgatg attttcattt 703021 atatgtgctg tgtgtcgacc agaaagcgta tgaattgctt cagcacgttc catgggagca 703081 tgtaaccttt gtgcagctgc atgaaatgga agacccggag ctgttgaaag cgaaaagcaa 703141 cagaacgttt catgaatatt gctggacgtt aaagcccgcc tttttgtttc atgtgatgag 703201 caagtgggat gacgctgaat actttgccca tatggatacg gatctatttt tcttttctga 703261 tccggcacgt atttttgcag aaaacccaac ggcgtctctg tatttgactg atcatcgtaa 703321 ttcgccgcgc ttcatgtcct actacgaccg aaccggacgc tttaatacag gctttgtcgg 703381 cgccggtaat acaaaggaag catatgaagc ggtgtggcag tggagacagg actgtattga 703441 attttgcacg gtcgaaatgg atacggaacg aaagacatat ggtgatcaaa gatatgtgga 703501 gaaatggccg gagcagttta aaggtgttca tgttgtcaaa tccataggag ccaatacagc 703561 gctttggaat atcgaaaact ataaggtcgg gcaaaaggac ggccgcgtgt atatagatga 703621 aacgccgctg attttctatc atttctctgg gtttacgctg gtgacagaaa aagagtttaa 703681 tctttgctgg tactaccgga ttgaagacga agcgacaatt aagatgattt atatgcccta 703741 tatattaaat ctgaaaagat ggattgatga aatacagtcg gcgtttccgg actttgcgga 703801 tggctttatc ccgaagcacg cagtgcctga cactcatttt atccagctgg attaaaaaac 703861 cccctgccgc ctggcagggg ttttttcagc tatgccattc tctcagcttc tggtcacttg 703921 gcaataggaa ggcaaggatg ccgaggacag ggagaaaggc aatggcgatc atcgtcgggg 703981 tcagtcccgc ggcatcaatc agagcgccca gcgccacagc gccgattgcg cccatcccga 704041 aggcaagccc gacggttaaa ccggacattg tgccgatttt tccaggaact agctcctgtg 704101 cgtagacgac cgttacagaa aagctcgaca tcagaaccaa gccaatcaat gcgagcacgc 704161 cgtaggcgag aaccgggccg gcaaatggca gcacaatcgc cagcggcgcc gagcataaca 704221 gcgaaccgag gataacgaag cgttttccaa aacggtctgc aagcgggccg ccgagaaacg 704281 tgccgatcgc gccgaacagc aagaagacaa aaatatagct ttgtgcctgc tgaatgctta 704341 cgtgataggt atccatcgcg taaaacgtgt aaaagttacc gatcgcactc gtataccaag 704401 aacgagcaaa aatgagaaat ataataataa taagagcaga tacaacagat ttggtgatgg 704461 ccgtgttttc agccgttttc ttttgcttgc ctgatttctg ggcaaggctg ccgagacgtg 704521 aggcgtacca tttcgcaata tacatgagaa acataacagc aagcgcggcg acaagcgtga 704581 accaaacagc gccgaattgc ccgagcggca caaggatcag cgcggtgatc agcggtgcca 704641 tcgcctggcc tgagtttccg cccacctgat aaatcgattg ggcgagcccg cgttttgtgc 704701 cggcggccat atacgccaca cgggagccct ccggatggaa aatggccgag cctaatccaa 704761 tgaaaaacac acagcataag atcgttatga atgacggggc aaatgcaagg cccaaaatgc 704821 caagcatgct ggcggtcaaa ccgactggca gcgcatacgg ccgcggccgt ttatcggtat 704881 accagccgac aacaggctgc atgacggatg acaccatgtt taatgtgaaa gcaatgatgc 704941 cgagctgtgt aaacgtcagg ctcatggagc gttccaaaat agggaacatg gccggaatca 705001 cagcctgaag cgaatcgttg agcatatggc aaattccgat aataatcaaa atcggataca 705061 ccgtggtgcc tggtttttga actgtttttt cttttaacgg ggcggcgata gccattgagt 705121 ctcctcctta catatataac caaagcatac caccatatta ttcataaggt gaagaattta 705181 tcaagaggaa aaaagattct tatgaaagaa ataccgtcag cctgattagc agctgacggt 705241 attttcgata ttcaaaatgt gatatagctc ttcaagctta cgaatctcat aggttggtat 705301 gatctctggc acattcggct tcatgtcagg gttcatccag caagtatcaa gcccggcgag 705361 ctgtccgcct ttgatatcag cagttagtga atccccgatg attaatgtgt gctctgctga 705421 aaattgagga atccgttcaa acacgtaatt gaaatattcc ttcatcggct tttggaagcc 705481 ggtgtcttca gaaacgaaaa tgtccttgaa gaatggaaat aatcctgaat cacggagacg 705541 cttatattgt gtgtgagaca cgccgtttgt cacgatgtac aaatcaaact gttgctgcag 705601 atttgagatg agatcaaatg caccgtcaat aagctgatgt ccttcttcaa gaaagcggcg 705661 gtatttttgc tcaagcaaag cgccgtccgc ttcgtaaccg tactccttga gcaaagcgga 705721 aaaacgtgtg tttacgactt catcccgtgt catcttacct tcttcaaagg ctctccagag 705781 accttgattg atggttttat actgcgcctt catgtcattt gttaaaggaa tgttctgatc 705841 ttcaaacagc aaacgcaggg ctaaagcttc tgccgcttga aaatcaagga tggtatcatc 705901 tacatcaaat aataaagtgc ggtatcgctt catctgtgtg tctccctttc tcatatgtat 705961 tcaaagtata gcacataaaa aaaggaaaaa gccggcgggt gaggcaccgc cggctgaaaa 706021 gagattattt gtttaataag ctgtgttttc tcgaatatag gaagtaaacc agcgttccga 706081 cagcgatcca gatgacaaat gaaagccatg tgacgccggg aaggctgtac atgaaccaaa 706141 ggcagatgcc tgcgctgata atcggcacaa ccggaacgaa tggcactctg aaggacgctt 706201 tgatttcagg atgtttcttt cttaacacaa tgacagcaat ggaaatgacc gtaaacgcgg 706261 caagtgttcc catgttcacc agatgggcca gcgttccgag gttaataaag ccggcgattc 706321 ccgctgcaac gatccctgtc agccatgtgt tgcggaacgg ggttttaaat gacggatgaa 706381 cctttgcgaa caatccaggc agaaggccgt ctctgctcat ggcaaatgtc aagcggacct 706441 gtgcgtacag caaagcgagc atcaccgtcg taatcccgat aatcgcaccg acagaaataa 706501 ttccggcaac agcgtcctgt ccgacgaatt tcagcgcaaa ggatacagga tctccgacat 706561 tcaatttggc ataaggcatc atgcctgtca gcacaagcga taccgcgatg tacagaaccg 706621 tacagacggc tagagctgaa ataatgccga cgggcatgtt tttttgcgga tttttcactt 706681 cctctgatgc gttagaaacc gcgtcaaacc caaggtacgc gaagaataca gtggcagcgc 706741 taagtatgac gcctttcatc ccgaatggca taaaaggaga ccagttatcc ggtttcacat 706801 agccgatgcc gacaataatg aacaataata tgatcgcgat tttcatcagt acgatgacgt 706861 tgttaaagcg tgtgctttcc ttgacgcctc tgctgacaat cgcagtgatg aggagaatga 706921 tcaccgcagc cggaaggtta aatacggcgc ccgccatgct tcccggcgct cctgtcagtg 706981 cagccggaat atgaagattg aagccggcaa gcagtgattg aaagtatgaa gaccagccgg 707041 tggcaaccgc cgacagtgca atgacatatt caagcatgag atcccatccg atcaaaaagg 707101 cgagcagctc tccaagtgtc acgtatgagt atgagtacac gcttcccgaa atcggaatgg 707161 aagacgaaaa ctcagcataa cagaaagcag ccagcgcaca ggcgagcccc gctaaaataa 707221 acgatatgat gagggcggga cctgcaccgg tcgctgccac tgttcctgta atgacaaaaa 707281 tccctgtacc gatgacacaa ccgataccga gcaaggttaa atcaaatgcg cttaacgtac 707341 gggcaaggct ttttgacttg ctctgcgcac tcaatgtttc aagcggtttt tttctaaata 707401 atgaactcat caaaagttcc tcctagaaat attcaaaata ttctaatcat tatatgcagt 707461 tcttgttgta ttatattgtc gaaatttgac gtagtcaata aaatattttt ctgctttaaa 707521 tgatagaagc gaaacagcgt tgtcgtatca taggatagta atttttacta atcgtatatt 707581 caattttatg caagatgaac cgatagaaaa aatagattcg cccatatttt gatttgcggt 707641 tataaaggag atgctgacca tgtttcaata tgaagagttg aataaacagt ttatcggcgg 707701 gaaatggcag gagggcagca gcccaaatgt attggaaaac aaaaatcctt atactcaaaa 707761 aacattcaca acattccgta aagcgactgc tgacgatgta gatgaagcgt atcgggcagc 707821 ggcgctggca aagaaaaaat gggatgcggt caacccgttc gagaaaagaa ccattttaga 707881 aaaagccgtc acgtatattg aagaaaatga agaagccatt atttatttga ttatggagga 707941 gctaggcggt acaaggctca aagcagcttt tgaaatcggt cttgtcaaaa acatcataaa 708001 agaagcggca acgttcccaa tccgcatgga ggggaaaatt cttccgtcaa caatagatgg 708061 caaggaaaac agattatatc gcgtgccggc aggcgttgtc ggtgtcatca gtccgtttaa 708121 cttcccattc tttttatcta tgaaatcagt ggcgcctgca ctcggagccg gcaatggcgt 708181 tgtgctaaag ccgcatgagg aaacgccgat ttgcggcgga acgctgattg cgaaaatttt 708241 tgagaacgcg ggaattccag cggggctgct gaatgttgtt gtcacagaca ttgctgaaat 708301 cggcgacagc ttcgttgagc atccagtgcc gcggatcatc tcatttaccg gttctacgaa 708361 agtcggcagc tacatcggac agcttgcgat gaagcatttt aaaaagccgc ttcttgagct 708421 tggcgggaac agcgccttca tcgtacttga ggatgcagat atagaatatg cggtcaatgc 708481 ggcggtgttc agccgattta cacatcaagg gcagatttgc atgtcagcca accgcgtgct 708541 tgttcattct tctatttatg acaagttcct tgagctgtac caggcaaaag tggaatcgct 708601 gaaagtcggc gacccaatgg accctgatac gattatcggg ccattaatca acagcagaca 708661 gacggacggg ctgatgaaga ctgtagagca agcaattgaa gaaggcgctg taccagtgaa 708721 gcttggcgga tttaacggga cgatcgtgga accgacgatc ttaaaagacg tcaaaccgtt 708781 catgagcatt gccaaggaag agctgttcgg accagtcgtc tcctttatga agtttgattc 708841 agaagacgaa gcggtggata tcgcaaacga aaccccgttt ggcttgagcg gtgccgtaca 708901 tacgtcaaat cttgagcgcg gcgtggcttt tgcgaaacgc attgaaacag gcatgattca 708961 cgtcaatgac acgaccatca atgatgaacc gaatgtagcc ttcggcggtg aaaagcaatc 709021 aggcctcggc cgtttaaacg gtgagtggag cctcgaagaa tttacaacgc tgaaatggat 709081 ctcggtccag cacgaaaaac gcagcttccc ttattaatga aaaggagtga atggaattga 709141 ccataaatac ggaaaaagaa accgcagata ttctggacgc atttatcaaa gtagcccctt 709201 atttaaacag cctggttcag gatgatatta caatcggcat ttatgatacg gaaaaactgc 709261 tcgtgaatat accggccaaa accttttcgc tgaacgtaaa agccggcgat ccgctgcagg 709321 aaggggatat catcacagat gccatccgca gcaatcagaa gaagacgagc atggttccga 709381 aagaattgtt cggcttccca ttgatcgcgc gtgccatccc gctgcacgac gagaatggaa 709441 gagtcattgg aggcgtcggc ctcggaacga gccttgagga gtcgtcaaag ctgcatgatg 709501 tcgcggaaag cttatcagct gttgttgaac aaacagccgc ggctatttcc gacatttctg 709561 aatcaattaa cgggttttca actcaaatgt cgggcatttc ctctcaggcg aaaaaagtaa 709621 gcgaaagcgc cggtgaaatc gccgatattt cagtaactgt taaaggcatc tcggaccaaa 709681 gcaatctgct cggcttgaac gccgcgatcg aagcggcaag agcaggggag tccggaaaag 709741 gattctctgt cgtcgcagat gagatcagaa agctagcgac gcattcaaaa gaaaatgtcg 709801 gccaaattga ccagattacg aaaaaaatcc acagcctgct gaaagggctg gaggaatcca 709861 ttgagtcgat taaccagcat acagacggac aagccgctgc tgttgaacaa atttccgcca 709921 cgatgcagga gatttcagga agcgcgcagc atcttgcgaa aatggccgaa aaagcgcttg 709981 aggaagagta agagaccggg gacaaacatc cccggtcttt ttcttatcct gcatttccat 710041 gaaattcgtc tgacgtttta ctagttttat tccagcggct gatttaaaat gtacacatga 710101 acttacgtga ggattgatag gaaccatgag catattaaaa gcggaaaatc tttataaaac 710161 atacggagat aaaacattat ttgaccatat ctcctttcat attgaagaga atgagagaat 710221 cggattaatc gggccgaacg gaacaggaaa atcaacgctg ttgaaagtga ttgccggctt 710281 ggaatctatc gaagaaggag aaatcacgaa atccggaagc gtgcaggtcg aatttcttca 710341 tcaagacccg gagctgcctg cggggcaaac agtgctggag catatctatt ccggtgaatc 710401 ggctgtgatg aaaaccttgc gtgaatatga aaaagcgctg tatgaactgg ggaaagatcc 710461 cgaaaatgaa cagcgccaga aacacctgct ggcagcacaa gcgaaaatgg acgcgaacaa 710521 tgcatgggat gcaaacacct tggcaaaaac cgtattgtct aagctgggcg tcaacgacgt 710581 aacaaaaccg gtcaatgagc tctcaggcgg ccagaaaaaa cgggtggcca ttgccaaaaa 710641 cttaattcag cccgctgatt tgctcatttt ggacgagccg acaaaccatt tggataatga 710701 aacgattgag tggcttgaag ggtatttaag ccaatatccc ggcgccgtca tgctggtgac 710761 gcacgataga tatttcttaa accgtgtcac caaccgcatt tatgagcttg aaagaggcag 710821 cctctacact tacaaaggca actatgaagt gtttttagaa aaacgcgcgg aacgggaagc 710881 gcaggctgag caaaaggaaa cgaagcggca aaacctgctg cgccgcgaac tggcttggct 710941 cagacgagga gcgaaagccc gctccacaaa acaaaaagcg agaattgacc gggtagagac 711001 gcttaaagag cagacaggcc ctcagtcatc aggttcactc gattttgcca ttggctcgca 711061 ccgtctcgga aaacaggtta ttgaagcgga gaacgtcatg atcgcttatg acggccgcat 711121 gctcgtcgac cgttttaatg aacttgtcat accaggtgaa cggatcggga tcatcgggcc 711181 gaacggcatc gggaaaacaa cgctgttaaa tgcccttgcc ggccgtcata cgccggacgg 711241 aggcgatatt acgatcggac agacggtcag aatcggctac tatactcagg atcatagtga 711301 aatgaacggt gagttaaaag tcattgacta tataaaagaa acggcggagg tcgtaaaaac 711361 ggcagatggc gatatgatta cagctgaaca aatgctcgag cgtttcctct tcccgcgttc 711421 gatgcagcag acgtatatcc gcaagctgtc cggcggggaa aaacgccgtt tatacttgct 711481 tcaggttctc atgcaggagc cgaatgtcct gtttctcgat gagccgacga acgatttgga 711541 tactgaaaca ttaagcgttc ttgaggatta tattgaccag ttcccaggcg tcgtcatcac 711601 cgtatcccat gaccgctatt tccttgaccg cgtcgtcgac cgtttgattg tatttgaagg 711661 aaatggtgtc atttcccgct ttcaaggctc ctatagcgac tatatggagg agtcaaaagc 711721 gaaaaaagcg gccccaaaac cggcagctga ggaaaaaacg gctgaagccg agccgaagaa 711781 aaaacggaaa aagctttctt acaaagacca gttggaatgg gacggcatcg aagataaaat 711841 tgcccagctg gaagaaaagc atgaacagct tgaagctgac atcgccgcag caggcagtga 711901 ttttggcaaa atccaagagc tgatggccga gcaggcgaaa acggcggaag agcttgaggc 711961 tgcgatggac cgctggacag aattgtccct catgatcgaa gaactggaaa gctaaaaagc 712021 gtggccgcag caggccgcgc tttttttcac ataatggaca aaaacgaacc ggcctgctta 712081 tgttaggata aagttgtgtg tcagcggcac atggaaaact aacggagatg atgaagtatg 712141 acatgggcga tcgtgatgtt aattctcatg agtctggtga aaatcgtatt aacctgtctt 712201 cctacaggcg tcatagaatg gctgctcggc aaatttgaag tgcacgccaa gctgagtgac 712261 gaaaatgcga gtctctctct agatggaaaa cgcctcgagg gtgcagagaa gcagaaagtg 712321 attgatcaat ttaacgaagc tatcttcctg gaaaaatatt atatctatcc aggtgatgaa 712381 gagcgttatt tacatccgga aaacggcggc acgcctctgg tgatagatac aaaaaaagga 712441 aaaaaagacg tgaagctgtt cgtgtaccgc tacgacgacc atatcgacgt cgtgaaacag 712501 tacaagaaga aagtgatcgc gtatcgagtg ctttctgaaa gccttcaaaa agagtctctg 712561 tcagtggcgg gaagtttagc ttaaacagga aagtgaaaga cgggtgctgt atgctgctcg 712621 tcttttttat tgttttttaa aacttaacgt ttacgttaag gttcaaaagg tgtataatgg 712681 taacagaaac ggcgaagggg gatttacctt ggaatggatg aagattgatc aagtggccaa 712741 aagaagcggg ctgacaaagc ggaccatccg gttttatgaa gaaatcggct tgattccggc 712801 gccgaaacgg acagacggcg gtgtaaggct ttattcagag gatgatatgg aggagcttga 712861 gaaagtcatc agcacaaaag aggtgctcgg tttttccctt caggagcttc agcatttcat 712921 ggaaaccagc cgccagctag agttaaacaa agaggggtat ttgttgtcac tggatcctaa 712981 ggaacggaaa gaaaaactgg aggaaattca ggaaaccctg aatcaccagc tggatttgat 713041 tgatgagaaa atccgcacat tccaaagctt taaagaacgc ctgcagggca tgaaaggcaa 713101 agcggaacgc gccattcaat caatcgaatg aaaagtttgt taaacgctat ttttgtagcg 713161 tttcttttaa tggaataaag atggaggtta ggtcaaatgg ataagacaac acaagtgaat 713221 cagaaaacgg gtttgctcag ccagccaaaa gcggtatggg ctgtcgcgtt tgcctgtgtg 713281 atttctttta tgggaatcgg gctggtcgat ccaattcttc cggccattgc cgcacaattg 713341 catgcttcac ctagtgaagt atcactcttg tttacaagtt atttgcttgt aaccggattt 713401 atgatgtttt tctcaggagc catttccagc cgcatcggcg cgaaatggac attaattctc 713461 ggacttattt ttattattgt gtttgcgggg cttggcggca gctcaagctc aatcgctcag 713521 ttagtcggct atcgcggcgg ctggggatta gggaatgctt tgtttatttc aacagcgctt 713581 gcggtcatcg ttggcgtgtc agtcggcggc agcgcccaag cgattatttt gtatgaggcc 713641 gcgctcggtc tcgggatttc tgtcgggccg cttgcaggcg gagagctcgg aagcatttca 713701 tggcgcgcac cgttttttgg agtatctgtc ctgatgttta ttgcgttaat cgcgatttct 713761 ttcatgcttc cgaagctgcc gaaaccggcg aaacgcgtcg gtgtgtttga tgcgatgaag 713821 gcactcaaat ataaaggcct gctgacaatg gcggtatcgg cattcctata caactttgga 713881 ttttttattt tgctagctta ttctccgttc gtactggatt tagatgaaca cggtcttgga 713941 tatgtcttct tcggctgggg ccttctgctg gcgattacgt cagtctttac ggcgccgctc 714001 gtgcacaaag cgctgggcac agtgcgttcg ctagtcgttc tctttatcgc ctttgcggcc 714061 attctcgtta ttatggggat ctggacagac catcagactt tgattattac atgtatcgtt 714121 gtcgctggtg ctgtcctcgg tatggtgaat acgatcatga caaccgctgt gatgggttct 714181 gcgccggttg aacgttcaat cgcgtcttca gcctacagct cagtccgctt catcggcggc 714241 gcgctcgccc cgtggattgc aggaatgctg tcagaacact ttactgcaag cacaccatat 714301 acagtaggcg gaatcgtcgt ttttgtcggc atgcttgtcc ttctcatggg acgtaaacat 714361 cttgctggaa ttaaggcggg gcattaataa cgaaagacac tgcgcatatg cagtgtcttt 714421 ttattcgtta taatgcatca taatcgaatt ggtgcaggaa aggacaacct ttatgacaca 714481 attttactat tttccggctg aaaactccct ttagaaaccg gttttttcgg tcagcaagaa 714541 cggcgttcgc ggaaagggca tccgcttcgg tcaggcattg atgcggctgg gatttatctt 714601 gcagaagctg agaatgtgtc cgttcattta cgattgccat ttcagtgatg gttcatgctg 714661 tagaggggac gtttgccatg gataaggcaa aacctgacga atatgatcag aaatgtttag 714721 aaacgctcta tcaatacata cacagcgtca tgaaaaacag cttttctcgg tcgagtggtt 714781 taccgcttgg gaagatgagg aggattttga gctgtctgcc aaaagagagc tgacacttga 714841 tgaattcaca tctccattgc agctcatttt aaaagacaga gagcttttga gaatcgttca 714901 gaaaaaatgg cagtaaaaaa cccgcccttt agcaggcggg tttttttata aattaaagca 714961 ctttcgtcgt ccaagactcg cagttccacg tttctgtcgc aatatccata taaaagtctg 715021 gctcgtggga aatgagcaga atggagcctt tatattcttt cagggcgcgc ttgagctctt 715081 ccttggcatc ggcatccaag tggtttgtcg gctcatcgag caccagcagg tttgtttctg 715141 agttgattag cttgcacaat ctgactttcg ctttttcgcc tccgcttaat acggagacgc 715201 ggctttcgat atgctttgtc gtcagcccgc attttgccag agcggcacgg atttcatact 715261 gcgtataaga agggaattcg ctccatactt cttcgatgca cgtattgttg tttgtttcct 715321 tgacctcttg ctcgaaatag ccggtataga tgtgctcacc gcgttcaaca gagccttcga 715381 gcggctggat ttcaccaagc aaacttttca gcaatgtcgt ttttccgatc ccattcgcgc 715441 cgtaaagggc gattttttgg ccgcgctcca tgcggaggtt gagcggacgg gacagcgggg 715501 aatcgtaacc gatcacgaga tccttcgttt caaaaatcag cttgcctgac gttctcgccg 715561 gcttaaagtg gaattccggc tttggctttt ctgccgcaag ctcgatcata tccatcttat 715621 cgagtttctt ttggcgggac atcgccatgt ttctcgtgct gacacgcgct ttgttgcggg 715681 cgacgaaatc cttcagctcc gcgacttcct gctgctgctt tttgtaggcc gcttcaagct 715741 gctgtttttt cacctcgtag acttccataa actgatggta gtcgccgaca taacgtgtca 715801 gctcttgatt ttcaacgtga taaatcaggt tgatgacact attcaagaac ggaatatcgt 715861 gggaaatcag gatgaacgcg ttctcgtatt cctgcaggta gcgtttcagc cattcaatat 715921 gctgttcatc aagatagttg gtcggctcat cgagaagcag aatttccggc ttttcaagga 715981 gaagcttagc gagaaggacc tttgtgcgct gtccgccgct caaatcggtg acatctcgct 716041 ctaaaccgat atcgctcaaa ccgagaccgc gggcgatttc ttccaccttg gaatcaatga 716101 cataaaaatc attgtttgtc agcgcgtctt gaatgacgcc gacttcttca agcagcttct 716161 cgagctcgtc gggatcagcc tcgcccattt tgttgtaaat ctcgttcatt tcctcttcca 716221 tcgcaaataa ataatggaat gcgtctttca ggacgtcgcg aatggatttt cctttttcca 716281 gcacggtatg ctgatcaagg tatccgacac ggacattttt tgaccattcg acttttccct 716341 catcaggttc aagctttccg gtaataatat tcatgaaggt tgattttcct tcaccgtttg 716401 cgccgatcaa gccgacgtgc tcgcctttta acaggcggaa ggaaacgtta ttaaaaatgg 716461 cccggtcccc gaaaccgtgg cttaaatcct ttacagataa aatactcatg tttacacctc 716521 tatcgttatc aaacacgcac aatcggcgtg taatattcac ccttttgatt ataaaggagg 716581 attcggaatg ttgaaaggta taggaaagaa aaagaaaaat tgcgttccgg gcgaggtttt 716641 gagatactat ggaatagatt tcaggaattg aggagaacaa aatgacgcaa acttggccat 716701 ttttacataa tgcacaatca tttatacaag agaattggaa tgcttccggc tttcaaaagc 716761 caacccctgt tcaggagcag gcagcccagc tgatcatgga cggaaaggat gtcattgcag 716821 aatcgccgac aggcacaggg aagacgctgg cgtatgcgct gccggtcttg gagcggatca 716881 aaccagagca aaagcatccg caggcggtga ttttagcgcc ttcccgtgag ctggtcatgc 716941 agatttttca ggtgattcag gattggaaag cgggctcaga gctgcgcgcg gcttccttaa 717001 tcggcggggc gaatgtgaag aaacaggtcg aaaagctgaa gaaacatccg catatcatcg 717061 tcggcacgcc aggcagggtg tttgaactga ttaaagcgaa gaaactcaaa atgcatgaag 717121 tgaaaacgat cgtgcttgat gaaacggatc agctcgtcct gccggagcat cgcgaaacga 717181 tgaagcaaat cattaaaaca acattaagag accgccagct tctatgtttt tctgccacgc 717241 tcaaaaagga aacagaggac gtgctccgcg aattggcgca agagcctgag gtgttgaagg 717301 tgcagcgaag caaggcggag gcagggaaag tgaagcatca atacctgatt tgcgaccagc 717361 gcgacaaagt gaagctgctg caaaagctgt caaggcttga aggcatgcag gcactcgtat 717421 ttgtgagaga cattggcaac ctgagtgtat atgcggaaaa actggcatat caccacgttg 717481 aactcggcgt tttgcacagt gaagcgaaaa aaatggagcg agcgaaaatc attgccacat 717541 tcgaagacgg agagtttcct cttttattgg cgactgacat tgccgcacgc ggtttagata 717601 ttgaaaacct gccatacgtg attcatgctg atattccaga tgaagatggc tatgtccaca 717661 gatcaggacg aacaggccgg gccggaaaag aaggcaacgt gctgagcctt gtgacaaaat 717721 tggaggaatc taagctgaaa aaaatggcga agaagcttgg tgttgagctg agtgaagctg 717781 tgtatgcagg cggaaaactg aagacgaaat aaaaagaagg gcgaagagcc ctttttttgt 717841 tgtaaaataa tagaaaagat tttgcgcgga ggtgggaaaa tggcttcaat agacaggttt 717901 caagtaatgc aggagccaga gctgaaaatc cttgaacact ggtttgagaa tgaggatacc 717961 agacggagaa tggatgggat gctgctatta gatgagtggt atgcacgagt aaataaagat 718021 aaacacgata ctgtcatcat ggcgtatgat ggacagctgc cggcagggat ggtcgttatt 718081 gagttcggag aggagcggac atatattgga ttgatcgtca atcctttgta ccggcttaaa 718141 gggtatggaa aacagatact gcaaaagctg atgaccgaac ctgattttac tagcgtgcga 718201 gaatgggtgg catgcattga agaagacaat cgaatcagtt tagcttgctt tcaagcagca 718261 ggattcactt tagaagacac ggaacctgat gaagatggtt ttcttacgct gattcttcgc 718321 aactgatctc atcgaaacac aaaaggaggg caaaaagccc tcccgttttc atcttcattc 718381 agctcggatc actgaccttg atcagctgtt tccctttatt ttctccctta aataaaccga 718441 gaaacgcgtc aggaatgttt tcgaagcctt ctgtgatggt ttcctcgtaa tggagtttac 718501 cagccttcag ccattctgcc agctgttttg ctccctcaga aaaacgatcg gagtagtcgc 718561 ttacgataaa gccttgcatc agcgacttcg ttttaatgag ttttgattgg acacgagggc 718621 ccatgtcatc tgcttcgctt tctgcgttat aggaagaaat ggcgccgcac accggaatgc 718681 gggcaaattc attgagcaga ttcatcaccg cgtctgaaat cggtccgccg acattgtcaa 718741 aatacacatc gacaccgtca ggacaagcgt tttgaagcgc tttttggata tcatccgctg 718801 ttttgtaatt gatggcttcg tcaaactgaa gctcctgttt taaatagtcg attttttcat 718861 cagagcccgc gatgccgacg actcgcgcgc ctttgatttt ggcaatttgc ccgactgttg 718921 aaccgacggc tccggcagct cctgagacaa ccacggtttc gccttccttc gggcgtccga 718981 tgtccagcaa tccgaagtat gctgttaagc cggtcattcc caaaatgccg agataggccg 719041 aagcgggagc aaggcttgta tcaatttttc gcaaggcaga ctcgctcaca gcggaaaatt 719101 cctgccagct gagatttccg atgacgatat cgcctttttt cagatgattc ccgtctgaca 719161 caacttcagc gataacccct ccagaaagcg ctttatccaa ggcgaacggc tcaacatatg 719221 acttcgtatc ctgcatacgg ccgcgcatat aagggtcaac cgatacataa agcgttttga 719281 caagcacttc cccttgcttg ggttcaggaa ccggaatggt ttcaaagcga aagtcttcat 719341 gaacaggaat accttgtgga cgtcttgcta attgaatttg ctgctgagat gctgtcattt 719401 tcatcctcct atcacttggt tgacaccact gtaacatgga caggagagga aatacaaaag 719461 gtaagctggc atacaaaaaa ggttatagat gagcttatgc tttctacaag ctcttttgtt 719521 ttaaaagttc tctttagtca tttatcatta ttagaaaaca gaacagaaaa agagctcctg 719581 tacacctagc taagattggc tagtgtgtat gtcgattctt tttcatattc ttgcaagcat 719641 ctgcgagggg gagcttagtc gttcacattt tgctttcgca tcaatctgca atagcaaagt 719701 ctatgcgatt tttttacatc agcaaagatt tgttcaattt tttcctttta tgccgagttt 719761 ttctgaaaca gataattgat ggtactcaac cattttcttt tggtcaataa agtaatgttt 719821 acttattaat taaacacgcg aaaaagcaaa cgaaaacata attaaatttt atatatttat 719881 taaaagctta tatgtttatt tacctttttt ttgaattgta attgagaaaa tccatatatt 719941 gcggacacta ataaaagaat acctgctgaa acataaacta aacgaactcc aaggaaatct 720001 gaaatagccc ctatagccag aattgaaaac ataaaaatga actgtactaa agaagacctt 720061 gcagacatta tattaattcg agtttgctcg gttgttatgt tctgaataag tgtttcttgt 720121 gtaagatctc ttaatatata agccggcccc ataaagagaa ccaaaattag agctaagtat 720181 gaattactta taaaaccata tattaaagtt aaacttccat atgagacagc gccaattaac 720241 ataaaattaa ttaacttatt ttgaaatctc tccgacagct tatatattat aaatccccct 720301 atcatcgaac ctaaataata tgctccatta ataaatcccc accatgattc tcctttatgc 720361 aagacttcgt taacgaaagc taaagagaca gatcctatcc aaatcattcc tgcccatgac 720421 tcaattaaat ccataataat aattgttcta agtttctttt ggctaaataa ataccgccaa 720481 ccacttacta tactcttatt gggagaattt ttttcacgta tgacagaatt agcgtggcca 720541 tgtggtagac aaaataaaag agaaagaaga gatgtaaaca acaaaaagat agtaagtata 720601 atggtatatc cctcacctaa aaatgcaatt atgagaccac ctaaagacca gcctacaaat 720661 tgaaaagttt ggtccactgt agataataat ccatttgctt ttactcttct atcaggagag 720721 attatttccc ctataattgc actttttaaa ggtgagaacc atccattaaa aaaggaaata 720781 cagctaataa taataaagac taaaatgaga gtttgattag agtaagttct taataaagca 720841 tagaacaaac atattaataa cagcatttgt atcaattgag aaataattat tgtaagaggc 720901 agttttaatc gaattgttat taacggtaat atagcacttc caaaaatacg aaaaataata 720961 cttattaatg tcaccataga ggcgatggtt gtcgaattgg tcattttaaa caaaaacgaa 721021 atcactacca tagtatatag agaaaaacct aaatttgtag tggtctggct aaataaaata 721081 gaataataac ctttactcat atgtatcctc ccttggaata atttttctcg gtaaagagct 721141 taaacatatt taaacacctt aaaacaacaa aagtaaagaa aaaatttcct tgtaaactat 721201 ttacttttat tctatttatt gttattgttt atttaagttc tctgactatt ctatcaatat 721261 tcagggaacc acatatctta ttaaaggggg gaaaaccatg agaaaattaa gaaaaaactg 721321 gagaaaatcg attgttagcc cggttcttta tactaatgaa aaatggtaaa cacttaggga 721381 atagcattta atgctattcc ttatttcaac aaacaaatcg ggaggttatc gtaatttgac 721441 tctattaatg caagatcata aatcaattta caataaagat atagaaatat taattgaagt 721501 tgaagaactt attacttctg ttccagaaaa taaaaaaaat gattttaaga gtttaatcga 721561 taatagaatt atgactctac taaataaaat tcaacaccct gtagcagcgg aaaatgtgtt 721621 tgggatgtgt attgcttatc cgaatactta cataaggtat agattaattg atttcgttga 721681 aaaatgggta ccttatttct ctgctgtaga aactataatc aatctaaccc aggatccgga 721741 tgatttagtt tcttttaaag ctatggatgt ctgtgcaaat cataaaattg aagaatctgt 721801 agcatatttg tcttcgatta ttgatgatgt ccgggagagt ataagctacc ctaaaaaacc 721861 tgtgggatta ggggcccaaa aagtattaag tacattatta gatatattcg gtgttgaaaa 721921 acatgaagag ctagtaatgc taaaaaatta ttttgatcaa aatggtatac ttcctaataa 721981 ctttgacttt gaagaaaaaa ttcctcaaag tctaatagag gaattcgaaa aaacagaaga 722041 agatgggatg attttaattc cgggtggctt ttttgaattc ggtttaaatg aaaatgaaat 722101 tcctgacaaa acatttaatt ggaaagatgc tgttcctaga caaaaagtat ggttacctcc 722161 attttttatc gataagtatc ctgttacaaa taaagattat gatatcttta ccgagttcat 722221 agaggaaaat gggcatatat tctgtcatcc taatgaaccg cagaataaac aacatagaag 722281 aaatacatat tgggatgata ggtatttaga taatcatccc gttacaggta tagattttta 722341 tgatgcattt gcttacgcaa gatataaggg gaaagaattg ccaaccgagt ttcaatggga 722401 aaaagctgct cgaggcgaaa agggtaatgt ctggccttgg ggagataaat ttgatcctgc 722461 aaaggttcaa tatgctggaa gtctttataa tgaacccatt acttctttaa agtcctggag 722521 agaaaattta ttaaaagctc atgctgataa agaattaaat catttaacaa gtgatatttt 722581 tgaacaaaat ggtgaaagtc cctatggagt atgcggtatg atcggcggaa catgggagtg 722641 gactagaagt gagcttaaaa caaagagagc tttccaccct atttttgaga atgtaccatt 722701 taatagtgtt aactcatttg ccgttcttaa aggaggatca ttcttctctc atccaggctt 722761 aatgttccct tcttttagag caaaagatat tcctttctgt cgacacaatg aaatggggat 722821 tagatgcgta aagaatattc cagtatataa aattagagaa tcaattaatg ggccaattac 722881 taataaagca atttattaat cattctaggt tagagacttg ataaaagtat actaacattg 722941 tgtagtaatg ttcagcttgt agaaaaaaca atgttttttc tacaagattt tattttaaat 723001 gcttttcaaa attatcaggg attgagaatc agaaaaagag ccattaagct cgatcttagc 723061 taggtattac gatcttctgt atattattgt gagaaatata gaagattcag ttagttagca 723121 tttcgatttt aagctgagcc tgcaatagca aagcatctgt tttgattatt ctttttctga 723181 tacataagct aattttgtcg cttttctttt ttgtcttttc acgcatttcg aggatgactt 723241 actataattc tttcagcttt tctatgtgtt aagattcgaa tagatgaaat aactttaaca 723301 agttggtcaa taagaacaga tttaacttta tgttaaaaga gtatctcgta tagaacataa 723361 gaagaatgac gagtttttta agattatcat caattatgtg agaataaaat attataaggg 723421 aaaatgaagg ctgtcacgtt tctcgacagc cctagggaat tcctctcctt ttcatttcgc 723481 ccgtaatttc gggcacagtc ccgtcggcag gcacattggc ttctggtcga tcgggcttct 723541 catgatgcag cattccaagc cgaagacttc acggaaaaat ggctgggtga acacatcttc 723601 cggtgttccg gcgttgtata tttttccgtc cagcacactg atcagatagt cagcatattg 723661 agcggcttgg tttaaatcat ggagcaccat gacaacggtg cggccatggt cgcggttcag 723721 ctttttcagc agttcaagca cttcaatctg atgtgagatg tctaaatacg tggtcggctc 723781 atcaagcaaa agcaaatcag tgccttgcgc aagtgccatg gaaatccagg ctctttgtct 723841 ttggccgcct gagagggcat caagtgtccg atccttcagt tcaatcatgc ccgttgcttc 723901 cagcgcccac tctaccatgt catgatcctc ttgggtatgc ttggataaca gctttttgtg 723961 aggatgtctg ccaaaatagc ataattcctc taccgtcaat ccttcaggag cctgaggaga 724021 ttgtggaaga atggccagtt tttttgcgac ttcttttgat ggctggcggt ggatgtcttt 724081 tccttctagt agcactgtac cgctttttgg ggccatcagc ctggcgagcg atttgaggat 724141 tgttgattta ccgcagccat tagcgccgat gagcgcagtg atttttcctt cttctatctt 724201 taagtcgact ccgtcaataa tcactgtact gtcatatgaa agagtgagct ggtctgcagc 724261 cagttttccc atggtatcct ctccctactg tttcctcgct tcgaatttca ataaatataa 724321 gaaataaggc gcgccgatca cggctgtcag tattccggca ggtatttcaa ccggaggcat 724381 gatgccgcgc cctaacgtat ctgcaattaa taatataata gcaccaatca atgccgatgc 724441 aggcagtaaa tatttagctt tttctccggt aagccgtctg gcgatatgcg gagcaagcaa 724501 gccgataaaa ccgattgagc cgacgacggc tacacagctt cccgccagcg ccaccgcggt 724561 gaaaatcagg atgaatctca gccggtttgc gttttctccg agaccctgtg caagctcatc 724621 cccgagtgac ataagatcca gcttcggtat gagtatgcag acgatcggaa aaagaatcaa 724681 aagccatggc gcaagcagct tgacttcttc ccagtttctt ccccagaggc ttcctgtcag 724741 ccaaatgagt gcagcattca cgtcgcctgg aaacttgacc atcatatatt gcattccggc 724801 gtggcagacc gcgcctaaag caatgcctga taaagccagt gaagagggct gaatgctctt 724861 ttttcgggct atcattaata atagtacagc aataatggcg gctccggcaa atgcggagaa 724921 cggaagcacg tataccggcg actcaggaaa gatgagaatc acagccatcg ccgcaagtcc 724981 ggagcctttt gaaatgccga caacgtccgg ggaagcgagc ggatttcgga tcacaccctg 725041 taaaatcgct ccggcagcgg caagtccagc acctgccaaa atcgctaata taatgcgggg 725101 aaggcgatat tgctggatga taaattcaaa ggaatgatcc agtcccagca gattcgtcac 725161 taccgcatca ggtgaaatgt ataatgcacc gattccaatg ctgatgacgg acagaacgat 725221 taaaatcacg gccaatatga gtatcgccag taaggggcgt ttttgttttc tggttgtttt 725281 cttcatttca ggtttcgccc tttccttgcc aaatataaga aaaacggcgt tccgataatc 725341 gcggtgacaa tgccgaccgg tgattcataa ggaaatgcaa tccatctggc cagaacatct 725401 gcgtacacca gcaaaatggc accgaacagt gccgaaaacg gaagcacgta ttgataatgt 725461 tctccgatca gcttgcggac aatatgcggg acgagcagcc cgacaaagcc aatcggcccg 725521 gcgacggcta cggaagcgcc ggaaagaatt aaaataatca aactgatcag aatcctgatg 725581 ccgttcatat tttgtccaag cccttttgct gtttcgtctc cgagaccgag aacagaaaca 725641 gaaccggaaa atacgagggc aagcccgatg ccaatgacag aaaaaggagc gatggttatg 725701 acgtcctgcc agttgctgcc gtcgattgcg cctgtcatcc agtacagaac atcctcacct 725761 gactcattta aaataatgat ggcctgtgtc atagaggaga ggaacaagtg cacggccatt 725821 cctgacagcg ccagcttgac aggcgtcatt ccgccggatg aggcaatcat atacacaatc 725881 gcgccgcctg ctgccgcacc cgcaaaagcg aatataacag atgaataggg cgatgccggc 725941 agaatgacga gagaagcaac aacaaaaagc gatgcacccg cattcacacc gaaaatttgg 726001 ggtgaagcca gaggatttct ggtcatagcc tgcatcagcg cccctgctac agctaggctg 726061 gcgccgacaa aaacgccgat taatgtgcgg ggaaggcgaa gagtagagat gatgagctgt 726121 tcctttgaac cgtcccatac aaaaagatat ttcaatgaat ctatgatgct gatgtctgag 726181 gctcctactg aaagattcag cccaagccca aatataaaaa taatcagtgc aatgataaac 726241 atcatcagtc ttgatgatga gcgccgtttg gctgaatgat acaacagtct cacttcctta 726301 ctgcgtctgg ttgcaaaaac gaagaagcaa ggattcccct cgcttctcat ttgtcctatt 726361 tattatacac ttttttaagc acatctttgg cgcttgtttc actagacttg atgcctctga 726421 atcttgtcca agtgtcacgg tccgcatcat agacttgtcc atttttcacc gctttgagat 726481 ttttccagag cgggttcgtt ttccactcat ctacaatggt tttgccttcg ttggctgaga 726541 tgaacaaaat atcaggatcg attttgctca attgctcaag gctgacctct tgataggcgt 726601 tatctgactt cacagcgtgt gtaaagccta gcattttaaa gatttctccg tcataggatg 726661 atgatgtatg aagctggaag gaatccgctc ttgcaacgcc gagaacgatg ttgcggtttt 726721 catctttcgg aagttcggct tttagatcgt tgatgacttt tttgtgctcg gcaagctttt 726781 cttttccttc atcttcttta tttaatgctt tagcaatggt cgtaaagctg tcgatcgttt 726841 cgtcatatgt cgcttcacgg ctttttaatt caatcgtcgg ggcgattttt ttcagctgtt 726901 tataaatgtt tttatggcgc tcagcgtcag cgatgattaa atcaggcttc aaggaactga 726961 tgacctcaag attgggttcg ctgcgtgtgc ctacagatgt gtaatcaatg gagctgccga 727021 caagcttttt aatcatatct tttttgttgt catctgcgat gcccaccggc gtaatgccga 727081 gattgtgaac ggcatccaag aatgaaagct caagcacaac cacccgctta ggtgtgccgc 727141 ttactgtcgt ttttccttct tcgtcatgga tcactctgga atccttagac tcgcttttgc 727201 cgcttccgtt gttattctgg cttgatgaac agccggatac aatgaggcag gcgagcaata 727261 aaacactcat gatggcaatc aacttgttag aataggtgcg catgtcattc ttcctttttt 727321 cagatttagt aatgagaatc attatcacat gtaacactat aatagcatgg cttatcatgt 727381 caatattttt ttagtaaaga aagctgcgtt tttactgctt tctcatgaaa gcatcatcag 727441 acacaaataa gtggtatgca gcgttaccgt gtcttcgaga caaaaacgca tgggcgttgg 727501 ctttagaggt ttcgaacata tcagcagtga cataaggaag gagagtgctg agataaccgg 727561 acaatttctt ttctatttca tctgttagtg caaattcaat gtcgccgata ttcatgataa 727621 tcgagaaaac aaagtcgata tcgatatgaa aatgttcctc ggcaaaaacc gcaagctcgt 727681 gaattcctgg tgaacatccg gcacgcttat ggaaaatctg tttgactaaa tcactcacaa 727741 tccaagcatt gtattgctgt tctggtgaaa agtattgcat tagacatacc tcctgctcgt 727801 acggataaag gcagcgtttc atggtcgtgt gctccgtgca gcggcttctc cttaattttg 727861 atttttctga aaataggtcc cgttcctatc actttaccat ggacggaaaa caaatagcta 727921 ctaccattcc tcctgttttt ctcttcaatg ttctggaatc tgtttcaggt acagacgatc 727981 gggtatgaaa gaaatataga aaacatgaag gaggaatatc gacatgaaac cagttgtaaa 728041 agagtataca aatgacgaac agctcatgaa agatgtagag gaattgcaga aaatgggtgt 728101 tgcgaaagag gatgtatacg tcttagctca cgacgatgac agaacggaac gcctggctga 728161 caacacgaac gccaacacga tcggagccaa agaaacaggt ttcaagcacg cggtgggaaa 728221 tatcttcaat aaaaaaggag acgagctccg caataaaatt cacgaaatcg gtttttctga 728281 agatgaagcc gctcaatttg aaaaacgctt agatgaagga aaagtgcttc tctttgtgac 728341 agataacgaa aaagtgaaag cttgggcata aagcaaggaa aaaaccaaaa ggccaatgtc 728401 ggccttttgg tttttttgcg gtctttgcgg tgggattttg cagaatgccg caataggata 728461 gcggaacatt ttcggttctg aatgtccctc aatttgctat tatatttttg tgataaattg 728521 gaataaaatc tcacaaaata gaaaatgggg gtacatagtg gatgaaaaaa gtgatgttag 728581 ctacggcttt gtttttagga ttgactccag ctggcgcgaa cgcagctgat ttaggccacc 728641 agacgttggg atccaatgat ggctggggcg cgtactcgac cggcacgaca ggcggatcaa 728701 aagcatcctc ctcaaatgtg tataccgtca gcaacagaaa ccagcttgtc tcggcattag 728761 ggaaggaaac gaacacaacg ccaaaaatca tttatatcaa gggaacgatt gacatgaacg 728821 tggatgacaa tctgaagccg cttggcctaa atgactataa agatccggag tatgatttgg 728881 acaaatattt gaaagcctat gatcctagca catggggcaa aaaagagccg tcgggaacac 728941 aagaagaagc gagagcacgc tctcagaaaa accaaaaagc acgggtcatg gtggatatcc 729001 ctgcaaacac gacgatcgtc ggttcaggga ctaacgctaa agtcgtggga ggaaacttcc 729061 aaatcaagag tgataacgtc attattcgca acattgaatt ccaggatgcc tatgactatt 729121 ttccgcaatg ggatccgact gacggaagct cagggaactg gaactcacaa tacgacaaca 729181 tcacgataaa cggcggcaca cacatctgga ttgatcactg tacatttaat gacggttcgc 729241 gtccggacag cacatcaccg aaatattatg gaagaaaata tcagcaccat gacggccaaa 729301 cggatgcttc caacggtgct aactatatca cgatgtccta caactattat cacgatcatg 729361 ataaaagctc cattttcgga tcaagtgaca gcaaaacctc cgatgacggc aaattaaaaa 729421 ttacgctgca tcataaccgc tataaaaata ttgtccagcg cgcgccgaga gtccgcttcg 729481 ggcaagtgca cgtatacaac aactattatg aaggaagcac aagctcttca agttatcctt 729541 ttagctatgc atggggaatc ggaaagtcat ctaaaatcta tgcccaaaac aatgtcattg 729601 acgtaccggg actgtcagct gctaaaacga tcagcgtatt cagcggggga acggctttat 729661 atgactccgg cacgttgctg aacggcacac agatcaacgc atcggctgca aacgggctga 729721 gctcttctgt cggctggacg ccgtctctgc atggatcgat tgatgcttct gctaatgtga 729781 aatcaaatgt tataaatcaa gcgggtgcgg gtaaattaaa ttaagaaagt gaaaaacaca 729841 aagggtgcta acctttgtgt tttttaatta attaaaatgt ttattaactt agttaaggag 729901 tagaatggaa aaggggatcg gaaaacaagt atataggagg agacctattt atggcttcag 729961 aaaaagacgc aggaaaacag tcagcagtaa agcttgttcc attgcttatt actgtcgctg 730021 tgggactaat catctggttt attcccgctc cgtccggact tgaacctaaa gcttggcatt 730081 tgtttgcgat ttttgtcgca acaattatcg gctttatctc caagcccttg ccaatgggtg 730141 caattgcaat ttttgcattg gcggttactg cactaactgg aacactatca attgaggata 730201 cattaagcgg attcgggaat aagaccattt ggcttatcgt tatcgcattc tttatttccc 730261 ggggatttat caaaaccggt ctcggtgcga gaatttcgta tgtattcgtt cagaaattcg 730321 gaaaaaaaac ccttggactt tcttattcac tgctattcag tgatttaata ctttcacctg 730381 ctattccaag taatacggcg cgtgcaggag gcattatatt tcctattatc agatcattat 730441 ccgaaacatt cggatcaagc ccggcaaatg gaacagagag aaaaatcggt gcattcttat 730501 taaaaaccgg ttttcagggg aatctgatca catctgctat gttcctgaca gcgatggcgg 730561 cgaacccgct gattgccaag ctggcccatg atgtcgcagg ggtggactta acatggacaa 730621 gctgggcaat tgccgcgatt gtaccgggac ttgtaagctt aatcatcacg ccgcttgtga 730681 tttacaaact gtatccgccg gaaatcaaag aaacaccgga tgcggcgaaa atcgcaacag 730741 aaaaactgaa agaaatggga ccgttcaaaa aatcggagct ttccatggtt atcgtgtttc 730801 ttttggtgct tgtgctgtgg atttttggcg gcagcttcaa catcgacgct accacaaccg 730861 cattgatcgg tttggccgtt ctcttattat cacaagttct gacttgggat gatatcaaga 730921 aagaacaggg cgcttgggat acgctcactt ggtttgcggc gcttgtcatg ctcgccaact 730981 tcttgaatga attaggcatg gtgtcttggt tcagtaatgc catgaaatca tccgtatcag 731041 ggttctcttg gattgtggca ttcatcattt taattgttgt gtattattac tctcactatt 731101 tctttgcaag tgcgacagcc cacatcagtg cgatgtattc agcatttttg gctgtcgtcg 731161 tggcagcggg cgcaccgccg cttttagcag cgctgagcct cgcgttcatc agcaacctgt 731221 tcgggtcaac gactcactac ggttctggag cggctccggt cttcttcgga gcaggctaca 731281 tcccgcaagg caaatggtgg tccatcggat ttatcctgtc gattgttcat atcatcgtat 731341 ggcttgtgat cggcggatta tggtggaaag tactaggaat atggtagaaa gaaaaaggca 731401 gacgcggtct gccttttttt attttcactc cttcgtaaga aaatggattt tgaaaaatga 731461 gaaaattccc tgtgaaaaat ggtatgatct aggtagaaag gacggctggt gctgtggtga 731521 aaaagcggtt ccatttttcc ctgcaaacaa aaataatggg gctgattgcg gctctgctgg 731581 tctttgtcat tggtgtgctg accattacgt tagccgttca gcatacacag ggagaacgga 731641 gacaggcaga gcagctggcg gttcaaacgg cgagaaccat ttcctatatg ccgccggtta 731701 aagagctcat tgagagaaaa gacggacatg cggctcagac gcaagaggtc attgaacaaa 731761 tgaaagaaca gactggtgcg tttgccattt atgttttgaa cgaaaaagga gacattcgca 731821 gcgcctctgg aaaaagcgga ttaaagaaac tggagcgcag cagagaaatt ttgtttggcg 731881 gttcgcatgt ttctgaaaca aaagcggatg gacgaagagt gatcagaggg agcgcgccga 731941 ttataaaaga acagaaggga tacagccaag tgatcggcag cgtgtctgtt gattttctgc 732001 aaacggagac agagcaaagc atcaaaaagc atttgagaaa tttgagtgtg attgctgtgc 732061 ttgtactgct gctcggattt attggcgccg ccgtgctggc gaaaagcatc agaaaggata 732121 cgctcgggct tgaaccgcat gagatcgcgg ctctatatcg tgagaggaac gcaatgcttt 732181 tcgcgattcg agaagggatt attgccacca atcgtgaagg cgtcgtcacc atgatgaacg 732241 tatcggcggc cgagatgctg aagctgcccg agcctgtgat ccatcttcct atagatgacg 732301 tcatgccggg agcagggctg atgtctgtgc ttgaaaaagg agaaatgctg ccgaaccagg 732361 aagtaagcgt caacgatcaa gtgtttatta tcaatacgaa agtgatgaat caaggcgggc 732421 aggcgtatgg gattgtcgtc agcttcaggg agaaaacaga gctgaagaag ctgatcgaca 732481 cattgacaga ggttcgcaaa tattcagagg atctcagggc gcagactcat gaattttcaa 732541 ataagcttta tgcgatttta gggctgcttg agcttgggga gtatgatgaa gccattgatc 732601 tgattaaaga ggaatatgcg atacaaaatg aacagcatga tcttttattc cataacatcc 732661 attcgcagca ggtgcaggcc attttgttag ggaaaataag caaggcatcg gaaaagaagg 732721 tcaagctggt gattgatgag aacagctcac tcgcgcctct tcctgcgcat atcggcttgt 732781 cccatcttat tacgattatt ggcaatttaa ttgataacgc tttcgaagct gtagcggagc 732841 aaagcgtgaa ggaagttttg ttttttatca cggatatggg ccatgacatt gtcattgaag 732901 tatcagacac agggcccggt gtgccgccag agaaaataga agctgtgttt gagagaggct 732961 attcttcaaa ggggatgagg agaggctacg gtctggccaa tgtgaaagac tcagtgcgtg 733021 aactgggcgg ctggatcgaa ctggcgaatc aaaaaactgg cggggcggta ttcactgtat 733081 ttataccgaa ggagaaacaa agggggaatc catttgattc acatcgcgat tgcggaggat 733141 gattttcgag ttgcgcaaat ccatgagaga ttgattaaac agcttgatgg attcaagatt 733201 atcggcaagg cggctaacgc aaaagagaca ttggcgcttt tgaaggaaca caaggctgat 733261 ttgcttctgc tggatattta tatgccggac gagcttggga ccgcgttgat tcctgatata 733321 cgaagccgat ttcctgaagt ggacattatg attatcacag cggcaacaga aacccgtcat 733381 ttgcaggaag cgctaagggc gggaattgcc cactatttga tcaaacccgt aacagctgac 733441 aagttcaggc aggtgctgct tcagtataaa gaaaaaagga agctgctcat gtctcagccg 733501 gaggtcagcc aatccatgat cgaccatatt tttgggaacg gtgtgaagac agctttgccg 733561 gcagaggatt tgccgactgg cattaattcg attacactgc gaaaaattaa ggaagcgctt 733621 cagactgcgt cagaaggatt gacagcggag gaacttgggg aaaaaatggg ggcgtcacga 733681 acaactgccc gccgttatgc cgagtacctt gtgtcaaagg aagaagcaag agccgagctt 733741 gaatacggga ttatcggcag gccggagaga aaatattatt tggcggcgga ttagatatga 733801 aaaaatctat aatcctattg aatattctat tgatctttat gcagggtgat atcaggcagg 733861 cggctgcgcc gcgcctgccg gacgggccga tagaaattgt cgtccctgcc gaaccttctg 733921 gcggctggga tgtcacagcg caggcgatcc aatcagtttt gaggcagaag cagatcgtga 733981 aggatgatgt tcatatcgtc tataaatccg gcggcggggg agagaaaggc tggaaatatg 734041 tcaacaaaag cagcaaacaa accatcagca tgacgtccag cctaatattg agcaatgatc 734101 ttctcgggca aagcaaatta aaaatgtccg attttacgcc gctcgccatt ctctccaagg 734161 aatggcagac ggttgcattg ccaaaaggat cagcgttaac aaatggcaag gatgtgctga 734221 atgagatcaa catgcatccc ggcaaggtga gaatcggctt tgccccgggg tttggcaatg 734281 atgatcagct ctcgttcgtc agagcggcag atatgtacgg cattgacccg tttgacattc 734341 aattctcaca gtatgacagc agcgaacagc tcattcaggc gctgatcaga catgagatag 734401 aagcggcttc catgacactt tctgaagcga aaccatatga acgaaacggc gatatcacgt 734461 tagccgctgt aacgtctgat aaaagacttc ccggttttcc aaatgtaccg acgtggaagg 734521 agcagggaat cccgtttgtt ttttctcatt ggagagggat tttgggcccg aaaaatatgt 734581 ctgaggaaga gatttcttac tgggatcaag cgctaaagaa ggtcacctcc tcacctgaat 734641 ggaagcggaa aataaacgaa caggactggg aaagctttta tttaaacagc agggaaacga 734701 aacggttttt agaagagcaa tctgcttttt atcaaagcat catgacagga aattaaaatc 734761 ccgacatccc gggatttttt tcatgccgaa aattgatcaa aaagaacaaa acggttttaa 734821 aaaattaaaa atacaaaaaa accaaattat ttacttgcgg ttggttttcc catacgatgg 734881 caaaaaggca agacaaaaag gggagtaagg gagaaaaaaa tgtaagcgga ttcatttaag 734941 ggggaatgga tgtgttagca atcttaggct ttctcatgat gcttgtgttt atggcattga 735001 tcatgacaaa acggctttct gttttaacag cattagtttt gacgccgatt gtgtttgcgc 735061 ttatcgccgg atttggattt actgaagttg gggacatgat gatttcgggg attcagcaag 735121 tcgcgccgac tgcggtcatg attatgtttg cgatcttata ttttggaatt atgattgata 735181 caggcctgtt tgatccaatg gttggcaaaa ttttaagcat ggtcaaagga gaccctttaa 735241 aaattgttgt cgggacagcg gttcttacaa tgctcgtcgc cttggacgga gatggctcga 735301 caacgtacat gattacgaca agcgccatgc ttccgctcta tttgctgcta ggcatccggc 735361 caattatctt ggcaggaatc gcgggagtcg gcatgggaat catgaacacg attccatggg 735421 gaggtgcgac gccgagggcg gcgagtgcgc tgggggttga tccagctgag cttacagggc 735481 cgatgattcc tgtcattgca agcgggatgc tttgtatggt ggcagttgcg tatgtgcttg 735541 gaaaagcgga acgaaagcgc cttggtgtga ttgaactgaa acagccagcc aatgccaatg 735601 aaccggctgc tgcggttgaa gatgagtgga agcggccgaa gctttggtgg ttcaatttat 735661 tgttaacgct ttctttaata ggatgtttag tatcgggtaa agtcagttta accgtactgt 735721 ttgtcattgc gttttgtatt gcgctgattg tgaattatcc caatctcgag catcagagac 735781 agcgcatcgc ggcgcattcc agcaacgtgc tggctatcgg ttcaatgatt tttgctgcgg 735841 gggtgttcac ggggattttg acaggcacga aaatggttga tgaaatggcg atctcgctcg 735901 tgtccatgat accggaacaa atgggcggat tgatcccggc gattgttgcc ttaacaagcg 735961 gcattttcac atttttgatg ccgaatgacg cgtatttcta cggggtgctg ccgattttat 736021 cagaaacagc tgtcgcatac ggtgtggata aagtggaaat tgccagagcc tctattatcg 736081 gccagccgat tcatatgctg agtccgcttg tgccatccac tcatttgctt gtcggactcg 736141 tcggagtttc tattgatgac catcaaaaat tcgcattgaa atgggcggtt ctcgcagtga 736201 tcgtcatgac ggctatcgct ctattgatcg gtgcgatctc tatttccgta tgataattca 736261 ggcgtaatga cacacactaa cggcatacaa cattccggag gtgtcattat gagtgatcct 736321 tatatgccgc tgacttcagt cagaagcgga gcggggttcg aagcggcaaa aggggtgcac 736381 ggcctgactg tgcaaattgc gaatgtctat tttattcagc tgccttctga acctcactca 736441 tttgttttaa ttgatgccgg catgccccaa tcagccggcg tgattgtcaa tgaagccaaa 736501 caaagattcg gtgaagggtt tcagctgaag gcgattatcc tcacacacgg gcactttgac 736561 catattgggg caatcgaaga gatccttgag cattgggatg tgcctgttta tatccattct 736621 cgggaaatgc cttatgtaac aggtaaagag gattatcctc cggctcgtcc tgacagcaag 736681 agcgggctgg tcgctaagct gtcgccgctg tttccgcggc actctatcga tatttcctca 736741 catgtccagg cactgccgga agacggttca gttccttttc ttgacgagtg gatgtggatc 736801 gcgacaccag gacacacgcc gggccatatt tcgttattcc gcgatgacgg ccgcgtgctt 736861 gtggcaggtg atgctgttat tacagtggaa caggagaaaa tggctgacgt cttgatacaa 736921 aaacaggagc ttcacgggcc gccggcttat ttcacgcctg acacagagac ggccgctgag 736981 tccattctaa agctggccgg tcttgaaccg gaagcgttat tgaccgggca cggcataccg 737041 atgaccggca aaaactttcg aagtgactta actgaattgg caaatcggtt atcgtctatt 737101 tgacacccgc accacgcggg tgttttttat tgttttccag gaagttgcag aaaaatcatt 737161 tgtcttgccg cttaaaaacg atacaatgaa aagcatgaag tgatgtgaag gggagagttt 737221 gttggaagaa aaagaaatac tctggaacga agcgaaagcg tttattgccg catgctatca 737281 ggaattggga aaggaggagg aagtgaaaga ccgtctcgcg gacattaaaa gtgaaattga 737341 cctgaccgga agctatgtac atacgaagga agagctggag cacggagcga aaatggcttg 737401 gagaaacagc aaccgctgca tcggcagatt gttctggaat tcgctgaatg ttatcgacag 737461 acgagacgtc cggacgaagg aggaagtgcg tgatgccctc tttcaccata ttgaaaccgc 737521 caccaataac gggaaaatca gaccgaccat tacgattttc cctccggaag agaagggtga 737581 aaagcaagtc gagatctgga atcatcagct gatccggtac gctggatatg agtcagacgg 737641 agaaagaatc ggcgacccgg cttcctgttc cctgacagca gcctgcgaag agctcggctg 737701 gcgcggagag cgaacggatt ttgacctgct gccgctcatt tttcgcatga aaggggacga 737761 gcagcctgtc tggtatgagc tgccgcgttc acttgtgatt gaggttccaa tcacacatcc 737821 ggacatcgag gcgttttctg atttggagct gaagtggtac ggcgtgccta ttatttctga 737881 tatgaagctt gaggtcgggg gcattcatta taatgccgcg ccatttaacg gctggtatat 737941 gggcacggag atcggagcga gaaacctcgc agatgaaaag cggtacgaca agctcaaaaa 738001 agtagcgtcc gtgatcggca tcgccgctga ttacaatacg gatttatgga aggatcaagc 738061 gctagttgaa ttgaataaag ctgtgctgca ctcgtataaa aagcagggtg tcagcatcgt 738121 tgaccatcat acagcggcaa gccagtttaa acggtttgaa gaacaggagg aagaagcggg 738181 cagaaagctg acgggggact ggacgtggct gattccgcca atttcacccg ctgccactca 738241 tatcttccac cgctcctatg ataactcaat cgttaagccg aactattttt atcaagataa 738301 gccttatgag taaacaatag aaaatcgatg atggccttca aggctgcggg attcagtcac 738361 agagatgtcg gtaacctttg agaaagggct tccgttcttt acagcctcaa caaacgattg 738421 cagggcgttt tccggaccct ctgccaaaat ctcgacacgc ccgtcatcac ggtttttgac 738481 ccagccggcc agttttcgct tatcagcttc catttgaaca aaatagcgaa agcccacacc 738541 ttgaacccgg ccgtctacaa tgattcggta ttgaagcatg taaaaaccac cttttctttt 738601 tatgataatc aatcatttta caacctgtaa aggggatgtg tttgtatgaa acaagagcgc 738661 tattcagttc tttctcttaa tctgggaaaa ccgcagacgc ttgaatatga cggaaagaaa 738721 atcgaaaccg gcatcatgaa gcggccggct aaatcagccg tcatgctgta tcgggagaat 738781 tttgaaggag acggacaggc ggacctcgtc aaccacggcg gacctgataa ggctgtctgt 738841 gtctacccgg cggagcatta tccgttttgg gaagagttcc tctcaagacc gctgtcaaat 738901 gccgcatttg gagaaaatct gacggtcgcg ggcctgactg aggagaatgt ttgcatcggg 738961 gatgtgttca gacttgatga agctgttgtt caggtcagcc agccgcgcca gccgtgtgta 739021 aagctggcga aaaagtttgg tgtaaaagaa atggtgctga aggtccagca aaccggctat 739081 acagggtttt attttcgcgt gctggaggag ggcagggtgt ctcccggcgc gaaccttgaa 739141 ttgctgtcca gaggagagaa aggcatatcc gtccagttcg cgaaccgcat caactaccat 739201 gatgcaaaaa atctcaccgc cattgaacgg attttaagtg aggctgcact atcggaaagc 739261 tggagagcgt cctttatgaa aaaaaaggac aggctgctgc cggttgaata gaaaaaagcc 739321 gcgcatatca acgtgcgcgg ctttgccata tttaagattg ttttttcttt gattcaagca 739381 ggttggcaag aaaataggtt ttatagcttt gaagctttct tccttcatgg tgcgtgatcc 739441 cctgcttttt tagttctgcc acataccagc ctttactgcc gtaatgcatg tcagaaaact 739501 cctttcccta tctgatttcg aaacgattgg cattgtaaca tctataaaaa gatgctgaaa 739561 agagatgcgg ggaaaactga gcctttcgca ctagatgtac gaatgttctt ctgaatgtat 739621 atgcggagca aaagccgaat atgatttaat ggccggttag tttgatcatg acaacgccaa 739681 atgtcataat ggcgaaaaca atgccgatat atgtgagcat cccgtttttt ttcttaacgc 739741 cgtaaacggt cataatgatg ccttcaatga aaaaaatgat gccgaaaata ataaaccaca 739801 tgcagataaa ggctcctttc acagacataa tagtagtgta gcatatctga aagagccggg 739861 ctgtgacaat atcaagaaag ccgggcgcat atcgcccggc tcatgtttta ttgtttatca 739921 accaatttga ccagaagctg tgccaaatgt tctttctcat cttcgtctgc aacgctccaa 739981 agctcttgca gcagcatttc ttcaccgttt tgcggctctt catgctttgc gaggtagtct 740041 cccaggatcg cagcgctttt tacaagcttg ccgtcatcca atcccagctt tttgcctcgg 740101 ttgacttgtt ttttcaggta gcctttaaat tcctcaaagt cttttaaaat gtcttctttt 740161 attgtgccat gcatcgcgtt catttcgttt tcaatttgga ttttttcttg atctctgttc 740221 attgcaagac ctcctcgtac agaataatga tgctttacct gcaattggag gaggttaaac 740281 ctgccggaag cccggaatgt gttttacagt ttcgtcagga taatcggttc atcttttgtg 740341 atgacgatcg tgtgttcaac ttgggcaacc atgcttttat ccggcgtctt gaacgtccag 740401 ccgtctccag cttcaacaat cgtttctgct ttcgttgaaa taaacggttc aagcgcgatg 740461 actgtgccat ttttgaacag cgcattatca aacggatcat aatagttcat gatgtggttc 740521 ggcgcttcat gcaggcttcg gccgattccg tggccggtca gggttttgat gacggtaaag 740581 ccttgagagc gtgcttcatg ataaacggct cttccgatct ggttttggcg cttgcccgct 740641 tttgcctgct gaagcccctt ttgaaaagcg ttttccgcgc attggcaaag cttatgaagg 740701 cgttcttctc cttcaccgag cacaaatgag atgcctgtgt cggaatagaa gccgccaaat 740761 tcagcggaga tgtcgatgtt gacaaggtcc cctgctttta aaattttgga tgtgcttggt 740821 atgccgtgag ccacttcatc atttacgctg atacatgtca cacctggaaa atcgtattcc 740881 ttctcaggag ctgaaacggc gccgtgctca tcaagcacag cttttccgat aaggtcaagg 740941 tcttttgtgc tcatgccggg ctctgccttc cgcttcattt cttcacgcgc aagcgcgacg 741001 attcttccga tttttttcag gccttctaat tcttgatcgt ttgttacaat catctgtcat 741061 tcccgctttc tttttaaata atctagatta agcttaccac aactgtctta aaaataggaa 741121 acacacggac ctgggaaaaa agaaataccc ccgggaaaat tggtatagat cactagatat 741181 cttatatggt atatttgaaa aaaaagggta tgagggggat gggtatgctt tcatttttac 741241 aaaaactcgg gaagtcattt atgctcccga ttgcggttct gcctgcggtt ggaattatcc 741301 ttgcgcttgg cagagaggat gtatttaata tcccgtttgt ctatcaggcg gggacggcgg 741361 tttttgatca tctgccgctt atttttgcga tcggtattgc catcggcatt tcaaaagaca 741421 gcaatggggc agcgggttta tcaggggcga tatcgtatct gatgcttgac gcggcaacaa 741481 agacaattga taaaacaaat aacatggcgg tgtttggggg aattattgcc ggtttaattg 741541 ccggttacac ctataaccgc ttcaaggata ccaagctgcc tgaatatctc gggttcttca 741601 gtggcagacg gcttgtgccg attttaacag ccattattac gatcatttta gcgggcatat 741661 tcggagtggt ctggccgccg attcaatcgt gtatcaactc gtttggagag tggatgctcg 741721 ggctcggcgg catcggggca ggcatattcg gcctattcaa caggctgtta attccgcttg 741781 gccttcacca tgtgctgaac aatattttct ggttccaatt cggagaatat aacggagtga 741841 caggggattt ggcgcgcttt ttcgcgaaag atccgactgc gggcacatat atgaccggat 741901 ttttcccaat catgatgttc ggtcttccgg cggcgtgtct ggctatggtt gtgactgcga 741961 agccgtctaa acggaaagcg acggctggaa tgatgattgg atttgcttta acggcgttta 742021 tcacagggat tacggagccg attgagtttg catttatgtt tttatctccg cttttatacg 742081 ctgttcacgc ggtcttaacc gggttatctt tatttatcgt caactggctc ggcatccgct 742141 caggcttctc tttttcagcc ggagctatcg attatgtgct cagctatgga atcgcggaaa 742201 aaccgctgct tctgcttttg gtaggtatat gctatgcggc agtatacttt atcgtgtttt 742261 atgtactgat taaggctttg aatttaaaaa cgcctggacg ggaagacgat gatgtggatg 742321 aagtgctgga tgaaaatact gttcaggatg taaatgaaaa catcatgctg aaagggctcg 742381 gcggaaaaga aaaccttcaa accattgatc attgcgccac aaggctgcga ctgactgtga 742441 aggataccgc tttggtggat gaagcactgc taaagaaagc aggcgcaaaa ggggttgtca 742501 aatcgggcgg gcaatcggtt caagtcatta ttggcccgaa tgtggaattt gcagctgagg 742561 aattgagggc tgctgtcaaa taaaaaagcg gagagggcaa cctctccgct ttttcttatt 742621 tatcttcgtt atcctttgac gtttcggaag aatcttcgtc atgttttgtg taatcataat 742681 cagaaggatt caccttctta aaacctttcg gctcgtagaa ccgcagcagg tctccgttta 742741 tgattttatc ggacatttca agttccttct tgacgagtga gtcttctgac ttgtcgactt 742801 cggattcatc gagttctttt ccggttttcg tgtcgtaata cttaccggat attttcgtgt 742861 acttcggtga aataaagtct ccgtttcgga acggaatcac ttcacggtgt tctttcgata 742921 aaatatcaga accggacatc agatagtcct tcgtatccac tccgagcaga tgcagaatgg 742981 taggagccac atcaacgtct ccggcatatt tatgaacttt ctcgcccttc acgccggcag 743041 cgtggataaa gagcggcacc cgttgaagct gggcgttgtc gtaatcagtg atttcatcct 743101 tgccaagcac tttcgccatc gctttattgt ggttttcaga gatgccgtag tggtctccgt 743161 acatcacaat aatcgattta tcatataacc cgtctttttt cagatcattg aagaattgtt 743221 caatggactg atcaaggtaa tgggctgact ggaaatagtt atcgacgaca gagtcaccaa 743281 agtctccagc cgggaagtct gtatccccct catccattcc gaatgggaag tggttggaaa 743341 gggtaatgaa cttcgtatag aacggctgcg gcaggctttc cagcagcggc attgattctt 743401 tgaagaacgg tttgtctttc atgccgtagt ttttcgtgtt ttcttcgttc atgtcatagt 743461 aagcagaatc aaagaattta tcaatgcctt ccgccttgta catttcgtta cggttccaga 743521 acgtctgcgt gttcccgtgg aaagtagcag atgtgtaatt cttagacttc agaatcgccg 743581 gaacggattg cagcgtgttt tgcgctttgt ttacgaaaac tgaaccttga gccagcgggt 743641 acagagagtt ttccatcata aattcagcat cagatgtttt accttgtccc gtttggtgga 743701 aaaagttatc aaagtagaac gtttcgttat catgtgccag tttatttaag aatggtgtca 743761 cttctttgcc gtcaatttta tagtcgatga taaatgactg caaagattca agtgaaacgt 743821 aaatgacgtt ttttccttcc gctttgccga aatacacgtt attcggcaca tcgtaattgg 743881 ctttcatgta gttttctact tccgttacgt cgctggaatc ggcaagcgcg cgctggctgt 743941 tggacttgat attctgtaca gcgtcataaa tcgtgaaatt gtatgttccc aagtatttca 744001 caagatagtt ccggtcgaat gatcttgtca gcaattcagg acggtctgat tccgcaactg 744061 ccaggttgat caagaacaca agaattgaag acgcaaaaat aattcggaac gattttttgc 744121 ttgacgtttc ggcaggcttg tttactttga tcgccaagat gatcaggatg atcgtatcga 744181 taaagtaaaa ggcgtcagtc ggtctcatca gcgaaaatgc gctgtcaccg agttggccgc 744241 cgtttgtttt agcctgcata atgaccggaa ttgtaataaa atcattgaaa aatctgtagt 744301 acacaatgtt ggcgtacagt aaaaaagaca ttaaaaaatg aatcactata atggctgtct 744361 gctgtaattt tttcttgaac aagagtccaa agccaagaaa gaacaagctt gagctaagag 744421 gattcacaaa aagcaatatt ttttgtatcg tgttgtctat tcctaagttg aaattcagga 744481 cataaccgac atacgttttg atccataaca ggacgaccgc aattaagaag aaggccagtc 744541 ctctttcttt tataaatgtt ttcattgtta cactcctttt ttccgatcca gttcgagcga 744601 aacgatagaa aaaacgaacg tatccaatat aacacgaatc agcagattag aaaagtgaaa 744661 atcgtatgag ggagaaagtg gcgaaaaacg ccgtcgaatc aacgtttcgc tttgatatta 744721 ccaaatgtaa aacaaggtat ctttctagaa ataaaggaat aaaatggtac attgagaatt 744781 gtatgataaa atataaggta tagataaaaa gaggtgaaat gatggatttt tcccatattg 744841 tgtctgaaga taaaattaag cgcgccatca aagacgggga ctttcaaaac ctcccgggaa 744901 tggggaagcc gctgccgaag gatgacgcgg cacacttgcc ggaatcgctg cgcatgggct 744961 atcgtatttt gaaaaacgcg ggaatggcag aggacgaggg cgcgctcaaa aaagagctta 745021 tgaccatcga ccatttaatc gaaaagtgct atgacgaaaa agaacgcgag caattaatca 745081 gaaaaaaatc tgaaaagcaa ttgctgcttg ataagcttgt cgacaaaaaa ggcatgtttt 745141 caaagccagc atccgctttt tataagaata aagtatatga ccggcttgga cgaaacagac 745201 cttcttccag ctgatttgtc ttgtctgcag gatggcgatt gataaaagcc atccttttta 745261 tgttccaagt tctatgtcaa aaggtttatg tttttccatc tatgggaaat gattcataaa 745321 cgaaaaaagg gtgatgggat ggaacgacta ttagtatgga tagagcatat atctgattgg 745381 ctgtggggtc cgccgctaat catcctgctg acggggacgg gcttgtattt cactattttg 745441 ctgaaaggtt ttcaatttcg ctatccttta tacattttca aacagacaat cggcagtgta 745501 ggaaaaaagc cgaagggaga aggcacagtc acaccgcttc aggcattgac ctcagccctc 745561 agttcaacga tcggtgcagc gaacattgtc ggtgtgcccg ccgctattat gtttggggga 745621 ccaggagcgg ttttttggat gtggcttatt gccttatttg ccatggcgat taagttttct 745681 gaaagtgttc ttgctgttca ttacagagaa aaaaatgagc agggtgaata cgtcggggga 745741 ccgatgtatt acataacaaa agggctgcgc atgaaatggc tcggcgtatt cttctctgtt 745801 gcgctgattg tggagctgat tcccagcatt atggttcagg gaaattcggt ttcagtctcg 745861 cttgccgaga cgttttcttt caataaaata tacgcaggaa tcggaattgc atttttgatt 745921 gggttagtgg tgataggagg ggtaaagcgg atcggaaaag taacagagtt tgtcgtgcct 745981 cttatggcag gggcatacgc aggtgccggt ctcctgattg ttctcatgaa tctatcatca 746041 gtgccggcgt ttttctctct cgttttttca aatgcgttta cctcttcttc agcagttgga 746101 gggttcgcag gtgctgcgtt ggcggaaacc gttcgctggg gatttgcccg cgggctgtat 746161 tctaatgaag ccgggatggg aacagccccg attgcacatg cggcagcaat gactgatcat 746221 cctgtgcggc aagggttttg gtctgtgatc ggcattgtca ttgacacctt aatcatctgt 746281 acgactaccg cttttatcgt ccttgcatcc ggtgtatgga cagggaagaa cgcctcaaat 746341 gacccggcag cactgacaac ggccgcattt cagcactatt tcggttctgg aggaggatac 746401 ttcgtttcgg tttccctggt cttctttgtc gtatcaacca ttatggttgt cattttttac 746461 ggcgtaaagc aagctgaatt tctgttcggg cggctggcag gacatgtgat taaattcgtt 746521 tatttagcgg ctattatcat aggtgccgca ggcggagcaa aagccatttg gggcgtattg 746581 gacttagcat tggtttttat tgttgtcccg aatgtgattg cgctcttgtt attgagcaga 746641 aaggtaaaag cgctgtacac cgaattcttt acatctgaac agtactacct gaaagatata 746701 agaaaaacga aacaaaagcc tgtttatcca acaaaagaag ctaaaaattc ctagtgtttt 746761 gcttttgcgc cgaacaatgc tttgcttttt atgatcaaat aaatgagtaa aggcagcaaa 746821 agagaaatca ctacattaat gattggtttg attctgttaa agtcgattag ctgatttgta 746881 tttaaaaaaa accaaaagcc gcatacgact gagaacatgc cggttggtgt atacatggct 746941 ttcgggtcga tttttgagtg taaaaacgaa aggccgtata ccacgatata tagggaacct 747001 gctatcttca ccataatgac cggaatccaa aaagccgcga tgatcaggtc tgagcgatcc 747061 agaaaatccg taatgcggat ctgcctgatg accatataag caggatcaaa gaaagtagat 747121 gtcaggttgg gaccaaagac agaaattgaa gaaaataaca tcacggccag caataaagcg 747181 cccagcagta tcgcgaaaat ggtgtatttt agcgggacgc tccggtttga gaagagaagc 747241 ggaaggataa tcaattcccc cattgtccca aacgcgtaat agcctgattg aaggtatggg 747301 attagacctt caaaaacagg tgtcaagttt tgaagctcaa tttgtgtggc cagcgtaaat 747361 ggaaggaaca agaccaggat gccgaatgga aataggaata tctgcgccat tctggtcaat 747421 gtttcttttc cctctctggc aatacagatc gccacaaaga taataacacc gccaagaaca 747481 gccattggtg ttctcgggag aaataaaatg ttaatcaaat tgatgaaaaa acgtatatca 747541 tgagcattga ttaacaggaa atacaaagaa aacagtaaaa tgataatccg gcctgcgatt 747601 ggtgaggaat cgctcagcag ctcatagata tttttatcct gatgcttttt catcagccta 747661 tgcatgagcc agagtgccgg aatcacgatg acaacgccga ggatgtagct gtgccaggca 747721 ttttgttttg ctgattcgat catgagaatc ggagcatgct ttaatccgac tgctaacgta 747781 tacagagctc cgaaaaataa tccttggtat gcagaggtct tgtccataaa gcacatcctt 747841 tctgtcatgt tcaaaacgga atatatttaa acaggtgccc cagccgcgga agcaggggat 747901 tcactctcat ataaatccat agaaaagcac ttcctgcaat tagcaggctg aaggcccatt 747961 ttgttagatt gttagcggaa cgaaaattct tccattcata tgcgtatatg gcaatgcaca 748021 caatcaatgt ctgtacgata tagctgatca tgctgacgca cctccattaa tggctgatcg 748081 ttttgtatag gacaccgccc tgctcaatcg tcacaattgg gacgacgtga acctccatat 748141 ccttatatac ctcttcccat tcctttttca gcagattctt cgtggttgcc gtgcttctga 748201 tggtcctgtc ttgaaagccg gccgggtccg cctttagctt ttgcaaacga tgaacggtgc 748261 tgatcacgtc cttctttatg gttctgttta atgctttttg aatgatgtaa tactggtcat 748321 tttctctcgt ctcataggtt gattggtttt ccataataat tcctttggct ctgatctcga 748381 ttgtcattga cagctttccg tttttttcag cggcatgaaa ggatgcattg gacttttgaa 748441 gctgaatgga tgcttgcccc atttgattcg gcaggtctac tatgaattct ggctggcggg 748501 cttgattcag caacatcagg gctgctgtca tgtgttcatc tttgaaaata tccatcaatc 748561 tgtccttttt aaagatcgca agcccgtcaa ttttcaaatt agatttgcct ttccctccag 748621 gttttgtttt agatgcagag atgaccggtg catacggatc actgcctatt tctactagat 748681 cagacatgaa tctgcttaag aaaacggggc ggctcgttgc gataatggcc agctcccgaa 748741 tcatttccgc cggaaactgt tcaagctgaa catcggtatt taaaatgtcc cgcgcttctc 748801 cccggctgac taaaatgagc gccgttaatc tgttctgcgg atttcgcgtt aaaatatcaa 748861 agactggggc aacgccgtct ctcgccatat cctctccaat aatgactgta cgtctgtggg 748921 acgtattgat tgtccgtgac aaggaggttt gcagcttgtt gttcgcttct ctgatcgtag 748981 tgccggaagc tgaatcaaca taccatgttt ttgaaccggc agttccgccg ccgccccctg 749041 tttgtccgcc taattggccg accaagggaa tctgcatggc cactcgatac tgatcttttt 749101 tcttatcaat ggctgagctg acaacaaatg caatgtcatt gatttctgtc cggtcccagc 749161 accccgttag aaggatacaa atgagaagcg gcaaaacaca cttatatatt gttttcttca 749221 tcttttgggt cctctctttt cgctcccttc tgtccgttgc cgcgcgaata cgtgcccggc 749281 cttctggtca tcgtccacca aggcgccctg acaaaaatat cttttacttc atctcgttta 749341 aacggagaaa tcccggataa ataaggaatg ccgaaagatt gcagcttgca taaatgaagc 749401 actaagataa tcgtgccgag cataatgccg aatatcccaa aaatactcgc caaaaacata 749461 agcgggaaac gaagcatcct gatggagata gctaagttaa accgcggaat tgtaaatgac 749521 gcgatccctg ttaacgatac gatgatcacc atgggggcag acacaattcc cgcttcaaca 749581 gcggctgtcc caatgactag ggccccgaga atactgacgg tctggccgat ggttttcggc 749641 aggcgcactc ccgcctcacg gagagcctca aaagaaattt ccataatcaa tgcttctatg 749701 atggcgggga aaggaatcgg ttcacgcgca gaggccacac tgaacattaa gtttgtcggc 749761 attaagtcct ggtggtatgt aataacggca acataaatag ccggcaaata taaagcaacg 749821 aataaaaaca tatagcgaag ccagcggatt aagttagaca tcaaataacg ctcatagtaa 749881 tcttcactgg cctgcataag ctgccaaaac gtaatcgggc ctgttaagac aaagggcgta 749941 ttatctgtga aaatggcaaa tcggccttcg agaagctggg cggcgacggt gtccggcctt 750001 tctgtgtatt gcagctgggg gaatggcgag tacgtgtcgt cttcgataaa ttcttcaata 750061 tatccgcttt ctaagacagc atcaatcttt atctttttga ttcttttttt tgctttgtca 750121 ataacctttg gatcggcaag cccgtcaata taggccaaga caacatcggt tttggttttc 750181 gtgccgattt taaaagagat cattttaagc tgaaacgttt tgacgcgaaa gcgcacaaga 750241 gcggtattga ccctgaggct ttcagtgaag ccctctcttg accctctgat ggtcgattct 750301 gttatcggct cttcaatgct tcttctttgt ccgcctttta tatttaagat caggcctttt 750361 gagtgcccgt cggcaaataa aaccgcgttc ccctcaatga tggatgcagc cactttgctc 750421 atactcgttt ctaatgcaac acttgaaatt gatagagtat tttgcagcgc ctcttcatgt 750481 tcatctattt gatccgtcaa atgcattaag aaagggcgga gggcgtgatc ctgaatatgt 750541 tcagatttta caattccttc gatataaaca ataaatccgc acagcccgtt tccaaagtca 750601 aattgtctaa atacgatgtc tgagcagcct tctgttaata aggtcagatt ttcgaggttt 750661 tccttcaaat tgggagagat cggtctgtcc tgattgtctt caagctcttt gatgagctga 750721 agcgctttgt cgcgtttatt catagaggct caccctgctt tttaatgtca tattcaataa 750781 gtgcttgtga cttttagggt aaccttgtct gtttcatata ttccagacta ggatgaaagc 750841 gctataaaaa agtgttgact acctgtatat acaggaatac aatatgatta taagttgtat 750901 atacaagtta taaaaacgga tacggagggg ttggcatggg ggaactgaac aaatcggcac 750961 gtcagattgt cgaagcagtc ggcggtgctg aaaatattgc agcggcaact cattgtgtta 751021 cacgtttgcg ttttgcttta atagatgaaa gcaaggttga ccaagagatg cttgatcaaa 751081 ttgatgtggt aaagggatca ttctcgacaa acggacagtt tcaggtcgta atcggccagg 751141 gaactgtcaa taaagtatat gctgaactgg ttaaggaaac ggggattggc gagtcaacaa 751201 aggatgaagt gaagaaggcc tcagaaaaaa atatgaatcc tttgcagcgt gctgtgaaaa 751261 cgcttgcaga tatttttatt ccaatattgc ctgcgattgt cacggcgggt cttttaatgg 751321 ggatcaataa cattttaacg gcggaaggca ttttcttcag cacaaaatcg attgtgcagg 751381 tttatccgca gtgggcggat cttgctaata tgattaacct gattgcaggc acggccttta 751441 cgtttttgcc tgcgttaatc ggatggtctg ccgtcaagcg gttcggcggc aatccgcttc 751501 tcggcattgt gctcggggtt atgctcgtgc atcctgattt gctgaatgcg tggggatatg 751561 gcgcggcaga acaaagcgga gagatcccgg tatggaatct attcggccta gaggtgcaga 751621 aagtcggcta tcagggccag gtgctcccaa ttttgcttgc ttcttatatg ctggcgaaga 751681 ttgaggtatt tttaacaaaa cgcacacctg agggcataca gctgctcgtt gtcgcaccaa 751741 ttacgcttct cttaacagga tttgcctctt ttatcattat cggcccgatt acatttgcga 751801 tcggtaatgt actgacttca gggcttatct cggtgtttgg ttcttttgcc gcactgggcg 751861 gtctgttata tggcggtttc tactcagcgc tcgtgattac cggtatgcat cacacgtttc 751921 ttgcagtcga cctgcagctc atcggttcaa agctcggcgg caccttttta tggccgatgc 751981 tggcgctttc taatatcgca caaggttcgg cggctctggc catgatgttt atcgtgaagg 752041 atgagaaaca aaaaggcctc tccctcacat cagggatttc tgcttatctt ggcattacag 752101 agcctgccat ctttggggtg aatctgcgat acagattccc gtttatcatt gcaatggtca 752161 gctctggcct ggccggaatg tatatttctt ctcaaggtgt gctggcaagc tccgtcggtg 752221 tcggcggcgt gccggggatt ttctcaatca tgagccagta ctggggcgcg tttgcaatcg 752281 ggatggctat tgtattgatc gtgccgtttg ccggaacata cgcgtatgcg agattcaaac 752341 ataaataaca agtggggagc gggacgtgtt gaacgttccc ttttcccgtt ttcaatttaa 752401 atatggtggt ggaaacagat gaaaacagaa caaacgccat ggtggaaaaa agctgtggtt 752461 tatcaaattt atccgaaaag ctttaacgat acgacaggaa atggtgttgg cgatctgaac 752521 ggcattattg aaaagctgga ttacttaaaa acgctacagg tggatgtgct ttggctgacg 752581 ccgatttatg attctcccca gcatgataat gggtacgata ttcgtgatta ttactcgatt 752641 tatcctgaat acggaacgat ggaggatttt gagcggctag tgtccgaagc acataaaaga 752701 gacctgaaag tcgtcatgga tcttgttgtc aatcatacgt caacagagca caaatggttt 752761 cgcgaggcga tctcttcaat agacagcccg taccgtgatt tttatatatg gaaaaaaccg 752821 caggaaaacg gttctgttcc gacgaactgg gaatcgaaat tcggcggctc ggcatgggag 752881 cttgacgaag catcgggcca atactatttg catctgtttg atgtgacgca ggctgatttg 752941 aattgggaaa atgaagaggt cagaaagcat gtctatgaca tgatgcattt ttggtttgaa 753001 aagggaatag acggctttag gcttgatgtc atcaacctga tttctaaaga tcagcgcttt 753061 ccgaatgcgg aggaaggcga cggccgctct ttttacactg acgggccgcg ggtgcacgaa 753121 tttctgcatg aaatgaacga aaaggtgttt tcacattacg acagcatgac ggtcggtgag 753181 atgtcttcaa caaccgtaga ccactgcatc cggtatacga atcctgacaa taaagaactt 753241 gatatgacat tcagcttcca tcatctcaag gttgactatc ctaacggcga aaaatgggcc 753301 ttggcgccgt ttgatttttt gaagctgaag gagatcctat ctgactggca aacggggatg 753361 cacgcaggag ggggatggaa cgctctgttc tggtgcaatc atgatcagcc gcgcgtcgta 753421 tcaagatatg gagatgatgg cgcatatagg gtgaaatcgg cgaaaatgct tgctacggcc 753481 attcatatga tgcagggcac gccttatatt tatcagggcg aggagctggg gatgacgaat 753541 ccgaagttca ctgacataag ctcctatcgg gatgtcgaat cgctgaacat gtatcacgcc 753601 tttaaggaaa aaggaatggc tgatcaagat attacagcca ttttacaggc gaaatcccgt 753661 gacaattcca gaacccccgt tcagtgggat gctacggaaa atggtggttt tacaacgggc 753721 acaccatgga taccggttgc aggaaattac cgggaaatca atgctgaagc ggcgctgagg 753781 gatcagaatt cggtgtttta ccattatcaa aaattgattc agattcgcaa aatgtatgac 753841 attgtgacag agggtacgta tgagataatt gcaaaggatg acccgaacat ttttgcgtat 753901 ctcagacacg gcagcaatga aaagctgctc gtgatcaata atttttacgg gacagaggcg 753961 gcctttacac tgccggactc tttagcgcct gacgaatgga aggcagaggt gctgttgacg 754021 aacgatgaag caagggaagg gcttcagaac atgacgcttc gcccatatga gtccattgtt 754081 tatcgtttaa cgaaaccgtg ttaaactaag ctgggtggtc cataatgaag gtgaataaat 754141 tcatcacaat ttataaagac atcgcacagc aaattgaagg cggccgatgg aaagcggagg 754201 agattcttcc gtctgaacat gagttgaccg cacagtacgg tacatcaaga gaaacggtcc 754261 gaaaggcgct tcatatgctc gcgcaaaacg gttatatcca gaaaatcagg ggaaaaggct 754321 ccgtcgtgct caatcgtgaa aaaatgcagt ttcccgtttc gggccttgtc agcttcaagg 754381 agctcgcgca aacgcttggc aaagaaacga aaacaactgt acacaaattc gggctggagc 754441 ctccgtcaga gctgatccaa aaacagctcc gggccaatct ggatgacgac atctgggaag 754501 tcatcaggtc tagaaagatt gacggggaac atgtgatttt ggacaaggat tactttttca 754561 gaaagcatgt ccctcacctg acgaaagaaa tttgtgaaaa ctccatatat gaatatatag 754621 aaggagagct cggtctttcg atcagttacg cccaaaaaga aattgtagcc gagccgtgta 754681 cggacgagga cagagagctg ctcgatttac gcggctatga ccatatggtc gtggtgagaa 754741 actacgtctt tttggaggat accagtttgt ttcaatatac ggaaagcaga caccgtctcg 754801 acaaattccg atttgttgat tttgcgcggc gggggaaatg agagaggcgc ctgcctgcgg 754861 cagcgcgctt ttttgtttgg tatcaaaatt gatactatcc aacaaaaatg tgcgtacttt 754921 tactttttat cataatggct acaatagaga tgagagtaat ctaaaggaga ggtgttttac 754981 atggcagatc taaagacaca aattctggat gcatacaatt tcaggcatgc gactaaggaa 755041 tttgacccga ataaaaaagt gtcagacagc gattttgaat ttattttaga aacaggaaga 755101 ctgtctccga gctcactcgg ccttgagcct tggaaatttg tcgtcgtcca aaatccggaa 755161 ttccgcgaga agcttcgtga atacacatgg ggcgcgcaaa agcagctgcc gaccgcaagc 755221 catttcgtcc tgattcttgc gcgtacagcg aaggatatca aatataatgc ggactacatc 755281 aaacgtcatt taaaagaagt aaaacaaatg cctcaagacg tgtacgaagg ctatttaagc 755341 aaaacagaag aattccagaa aaacgatttg catttgcttg aaagtgacag aacattgttt 755401 gactgggcat caaaacaaac ctatatcgcg cttggcaaca tgatgactgc cgctgcgcaa 755461 atcggtgttg attcctgccc gatcgaaggc ttccagtacg atcacattca ccgtattctt 755521 gaagaagaag gccttctgga aaacggaagc ttcgatattt ctgtgatggt ggcattcggc 755581 taccgagtga gagaccctcg tccgaaaaca agatctgctg ttgaagatgt tgtgaagtgg 755641 gtttaaaaga agaaagctgc tcgcatagcg agcagctctt ttttatgcct gattcgctct 755701 attctgtttt ctcctctgat gtaagtacat tgccgttccg agtgcgctga tcagaaatcc 755761 ggccaacagg atcgagtaca tggatgtggc tgtgtccgga agcaggccgc cagccggacc 755821 gtctgttcct gatccgcccg aaccgtttcc accagagccg ttagtcggtt gagtgccggg 755881 aggcgtatca tttcctccgt ttccgtcagt tggctgtttt ccgcctggtt tgtcggagcc 755941 tccgccatga ttgccgtcat caccgcctgt cggttgatct gacgggaatg ccggcggttt 756001 gttgtttgaa ccggaattta agatcgtgta ttcgctgaag tggtttgtat atcctgtcac 756061 catatcatca tcgactgatc cgtgacctgt ctttgtgaaa gctttctttt ttctatcgac 756121 gtgataaatg gcagggttat gggcttcttc aatatcaaac atgcgaagcg aaagctgtac 756181 gggctccttg aatgatttta tttcttttcc tttttgcttc actgtaaagt catatacatc 756241 tgacagtgac acatccaatt ctcccgtaga cttgattccg attgcagtgt ctgcggtttt 756301 aaggttcgcc attggcatct tcatgctgta ccagtagttg aacatcgtca atgaaggatc 756361 tgactctctt tctttcaaaa gtttgacctg atcttttttc actttaagat tgataggctt 756421 ctcttgagat ccttcatgta ttccataata gacaaatggc gtgttggcat ttttagcata 756481 aatcgcaaat ttgtcttcat caagtgtcca gctgccgtcc ttctgctttg tcggcaggaa 756541 tacttctttg attcgtcctt caactttagg agagaccttg tttcctagtt ttttcagctg 756601 ttcggtgaaa atctcataat caacgtagcc aaggtcttca ccatgggagg cttctgtaaa 756661 gacagaatat ccgtctcctc cggcaccgac aaaattattt gttgccacgc ggtaggtatc 756721 atccgtattt atagcaactt tgtctccgtt aggcgattca attttcactt ctaacacacg 756781 gtgtccaggt ttgttgttta atgtaaaggt atattcgatt ccggccacct gagggaaagc 756841 gccgccgcca ttttccacat tgcttaggcc ttgttcaagg gcttctttaa tttgttttcc 756901 ggttaaatcg gccacgtaaa gcgtattgcc gaacggcatc acgttgagca cctcgccgag 756961 tgtgatatca cctttgtcaa tgcctgctct gatgccgccg ccatttgtta tcgctattct 757021 ggcgccggct gcttctttcg cttttgccag cataccgtcc gcgatgaagt ttccgagatt 757081 cgtttctttc gtgcgcacat gctcacgctg gccgtcaagc gccacatccg tgtagccgac 757141 tttttcattt ttcacgtcct ctaattcatt tttgaactga tcgagctctt gttttgcttc 757201 tgggttttct tctgtatgtt catcaattgg cagcacgctc agatttgatt tatctgtttg 757261 cacaacgcct ttttcatcaa acgcgacatc aacgcgcccc aagaattggc cgtattcttt 757321 tgcctgcgcc acgatcgtcg gttcttcgtt gttcacgacc tccattttgt ctacgagggt 757381 gtgagtgtgt ccgccgatga tcaaatcaat gccttttact tttttggcta gctcaagatc 757441 ccggttatgt ccgatgtggg ttaaagcaat aattttattt accttttctt cttcttgaat 757501 cgctttgacg gtgttttgtg ctgtttcaaa ggcatcattg aatacgatgc ttttgcccgg 757561 gcttgatgtg gtggctgtat cttctgttgt caggccgaat acggcgactt tctccccgtc 757621 aacgtctaac agaatgtaag ggtgaatgcc ggcctctttc ttttcacctg ccgtaaaggt 757681 ttgcggcttt ttgacaaatg atttcagctt gggctcattt gacacatcta cgtttgcact 757741 gacaatcgga aattccggcg cttcaaagtg atagcggttc gccggatcaa cggttgcgct 757801 gtttccgctt agaaaatcag aaagcaccgt cgggcctttg tcaaattcat ggtttccgaa 757861 ggtcatggcg tcatagccca tcatgttcat cattttcaga tcggccaaac cgttccattt 757921 agtaaaatac agatcgccgg aaaacacatc tcccgcatca aggagaatat tgtgatttgt 757981 ttcgctgcgt acttcgttga ttttcgtcat tcgtctcgct gcatcatcga gatgggcgtg 758041 cgtatcattg gtgtgcatga cggtcagatc ccacagtccg tctttaggag gatctggatt 758101 tgaatcatca tcgaattgca gcttatacac accatagcct tcattcgcag acttgcctac 758161 ataagcgaca tcgtctgctt tatcggcaaa tggcttggcc aaaagcgagg attcaaacgt 758221 cagattcgtg ccggaaacag gcgcgattga ccagttgttg tctgcttttg gattgactgt 758281 tttttgttca ataatgtaat ccatcagcac ctgcctattt tcaactgcag agccgtggac 758341 aattttatcg ctcgtcagat gagggaaccc gccgcctccg gacgcacgat agttattggt 758401 gactacgaga aattcctggc ttgggctgat cggcttgcct tcataggaaa gattgatgat 758461 acgggatgaa tccgcattga tcacttttcc gttctcattg tatttagccg gttttgtcac 758521 atcgacctga tatgtgacac cgtcaatcac gtcaaaatta taggagcgga aattctcgtt 758581 cagcaaggcc tggtcgccgc ctttagctgg atcaatttga ttgaattggc ctgctgacat 758641 ctccagccag tccttgacct cgctgcctgt cagcttgacg atttgaacag tattatcgta 758701 aagatacaag tcaccgacat ttttaatcgc aagatctccg gctggaatgt ttgtatagta 758761 attggctccg tttctgccgc ctgctttaaa cggcgctcca gcggataaaa tcggcaggtt 758821 cttgtactcg gtatccttca tttctttttc agcgtaccac ttttgcgcgt cagtcacgat 758881 ctgaatggaa ggatcatctt tgacctgtgc aaagaagctg ttaatatctg cttcggtttt 758941 gccgactggc tttcggacat actccagtgt gttttggtgt gtttgctgaa tggtgtttgt 759001 aacggtttcg tttcttgatg tgacgttgcc agcaatagat tcaatacttc ctttggaatc 759061 tgctaccttc catgagccgt ccgccttttc aagcttgagg tcaatcacgc ctaaatattt 759121 gccccagctg cttggcatga cgacaggaat gccgttaatt gttccctttt ccacattgaa 759181 ctgagcaaca cccgcatact cggcggaagg aaagagtccg tgctgatggc ccgagataat 759241 cgcgtcaatg cctttcgttt tggtggcaag gtcaaacacg gcgttttctg cgcctgatga 759301 ttgcgcctgc ttttcaatgc cggtgtgggc gagggcaata atgacatctg cgccttccgc 759361 cttcattttc gggatcgttt cattggcgga ttctacgata tcctgcacct gaacttgccc 759421 ctcgagattc tttttgtccc atgtcatgat ttgcggcggg acaaagccta tgtagccgac 759481 ttttactttc tgctcattac cgttttcatc aatgagggtt ttttcattaa tcacatacgg 759541 cgtataacgg ttttcgccgc tagttgtttt gacgttggca tttacaatcg ggaaatcggc 759601 tcctttgatt gtgccgtcga gaaagtcgag cccgtagttg aattcatgat tgccaagcgt 759661 tccggcgtcg tatttcagcg cattcatgac gctgataatc ggatgggttt tcgtgccgga 759721 gataatgtcg tctttttgat atttcaccgc gtattcaccc agcggattcc cttgaatcaa 759781 gtcgccgtta tccacaagca gggtgttagg gttttgctcg cggtgctttt ggatcaattg 759841 cgctgttctc gccagaccga aatccgccgt ttctttgtcg ctgtagtaat cgtaatccat 759901 catgttggca tgaatatcag tcgtagccaa aatactcaga tgcacctgag gagccgcgct 759961 ttcttctgca tgaatgggtg gtgttgggag gattaggcta agtatcataa ttgggggcaa 760021 aagaatacgg agaatgtttt cgacgtgtgt tcgtcttttc tgtattctca ccagttctcc 760081 acctttcaac gaaatttgtg ttacagctcc tattgtaaga atattttgta actatttgta 760141 ggtgtttctt tatgattatt gtaaaaggga gaaaaatgag tattatgtag cagtatcaaa 760201 cgacaaatac tgggcattta tgcttatcgt ttgtcacaat cgcggaatgt ttattttagt 760261 gtggctgggg tagagtgttt tatgtagaca tataaagcgg gaggttatga atcatgggga 760321 aaaaaattgc agttgtttta acatattatt ttgaggacag cgagtacact gagcctgcga 760381 aagcctttaa agaagcggga catgaactga ctgtcatcga aaaagaaaaa ggaaaaacag 760441 taaaaggcaa gcagggaaca gcggaagtga cggttgacgc gtccattgac gacgtaaatt 760501 cttcagactt tgatgcgctt ttgattcctg gaggattttc accagaccag cttcgcgctg 760561 acgatcgttt cgtccaattt acaaaagcgt ttatgactga caaaaagccg gtatttgcca 760621 tttgccacgg cccgcagctt ttaatcaatg cgaaagcgct cgacggccga aaagcgacgg 760681 gctatacgtc cattcgtgtt gacatggaaa acgccggtgc cgacgttgtg gacaaggaag 760741 tggttgtttg ccaggatcaa ttggtcacta gccgcacacc ggacgatata ccggcattta 760801 accgcgagtc attggcattg cttgagaaat aagaaaaaac ggacgctctt gggcgtccgt 760861 ttttttgttg cttaggcttg agcacctgtc agtttcttgt acctgtaata caagaaagca 760921 gctgcagccg ttccgatgac cgcaatgccg aagtcgaata tgaaaatatg ggcgatgccc 760981 cccgcttttg cgataagccc tgttgcaatc ggcagcagaa tcgatgcaag acttgaagca 761041 gtcgctacaa ttccggtaac ggttcctttt cgcttccaga aaagctctgt cattaacgta 761101 atggtaattt gaaacacacc cgcagttgaa aagcctaaga aaaaggcagt gatgtccagc 761161 acaactggga tatgaacggt cagcatgact gcgagcgtac ataaagtaat aataggatat 761221 aagagcgtta tgaagacagg tttgacccat ctattcagca aaacggctaa taataaaaca 761281 gatgccagag atcctatact ataatagctc agcaattgta cagatgctga ttcagctaaa 761341 ccggctgcct tttgcgcgta gctcgggagc cagatttgag aaaccgtaaa taaagccgtg 761401 gatgtaaaac cgatgataat cagtgcggtg ccttccttct gaaaaacggg ttcagacaag 761461 aaaacgggag attcctgttg gccgctatta gttggtttct tatgtttttt aggaaacgaa 761521 agcgttgata aataaataat attcaggaga tagaccgctg ccggcagata aaaagcaaat 761581 ccgtaaaaca tgctgtggtc tgctaaaaat gtgatcaaaa gcggcaaaag tgcggccccc 761641 acagacataa aggctttaac caagacattt gccgaaccgg aagcagacgg aaagagctcg 761701 gttagggccg gatatgttcc ggcatccatg gctgaattag cgactccggc taataaagcg 761761 aacacaaacg ccagctcata gctcggtgat aaaggaatac cgactaaaaa gacggccata 761821 attcccgcag aagcgacaac aagcggcttt ctgccgattt tatctgatag aacgccggaa 761881 atgccgtatg tcagcagttt gccaaacccg atagcggcaa tgacataact gatgccggtc 761941 ggatcggtat tccactgttt tgttaatgaa gacatattgg atgcgagaat gatgttgacc 762001 atccccagaa agaagtagtt gatatacatt ccggatgctg ttttgataga tgtcgtttgc 762061 atgcttgtac tccttcaaat cttattcgaa cactttgctg ttttggtttg gggaaatgat 762121 aaaaaagact cgccgagttt ccggccagtc tccattattt acgaagcgag gctaattctt 762181 gagcaatcgc ctgcatttca cttgggctga atgattcttt tttcatcacc attctgtgaa 762241 ggtacgtgag gtcttcaatc ttctcatcac tgaaatcctc cgctttgatt acgccgacgt 762301 tcagcatgtt cagcttttgg gaaatctctt caatcatttg agttaatgtt tctgtatttg 762361 ggctggacaa agggttccat cctttctatg cgcaatatag gtatgtttta ttctaacaga 762421 attccatcag aaaaaaaccc tattctaaaa gcaggctgtt cattccaaaa aagtgaagac 762481 atcagttgaa aagaaaatga acatcctact aagatattca tgaaggtttc tttttagaga 762541 aataggggca aagaataggg aggttgcaca tcatgataag cgtgttattt gtttgtttag 762601 gtaacatttg ccggtctccg atggcggaag cgatttttag ggacctggca gccaaaaaag 762661 gattagaggg gaaaatcaag gcggactcag ccggtattgg cggctggcac atcggcaacc 762721 ccccgcatga gggaacgcag gagatattgc gcagagaagg aatcagcttt gatggcatgc 762781 tggcgcgtca agtcagcgaa caggatctgg acgattttga ttacatcatt gcaatggatg 762841 cagaaaatat cggaagtctc agaagcatgg cgggttttaa aaacacctcg catatcaaaa 762901 ggctcttgga ctatgttgaa gattcagatc tggctgacgt acccgatcct tactacacag 762961 ggaactttga agaggtctgc caattaatca aaacgggctg tgagcagttg cttgcatcca 763021 ttcaaaaaga aaaacaattg tgagtgaaag gagaatttgc atgaacaacg aacgtttaat 763081 gctgaaaggg atatttctcg gagctgcggc aggcgcggcg ttatcactgc tccataagcc 763141 gacaagacag gcgtgcggga tgagatggct gacatgcaag cataaacttt cactgtacaa 763201 aagcaaccca gagctgttaa aaaacactgt catcacaaaa gtggatgagg ccaaaaagct 763261 cgcccgaacg ctttcaaagg aagtcgactt tgtgaaccag caggtgaaag agctgaagaa 763321 aacaacgccg caagtgatgg aactcgtgca agaaacgaaa gagcattttt caaaaaaatg 763381 atcaaacatg cgaggtgaga cgacatgagt tttttgaaag agcttttcag cagatacacc 763441 cttcatgaag gacaaagtaa atcagcggag ctggcgtatt tttttctatt gtcactgttt 763501 ccgtttttga tttttatgct gacgctcacc gcgtatcttc cgctttctac cgatgatgtt 763561 ttaggagtca tagaacaata tgctcccgcc agtgcgatgt cactcgttga atccattacc 763621 catcaaacct taaataatcg aaatggcggt ttgctgtcat tcgggattat cgccgcatta 763681 tggtctgcgt ctaatggaat gaatgcgatc gtccggtcgc tgaaccacgc gtatgatgtg 763741 gaagaaaacc gctcttttat cattgttcgt ctaacctcga tttttttgac gattgccatg 763801 gtatttacga ttttagtggc tttgcttctg ccggtatttg gccgggagat tggaaggctc 763861 gcttctgact ttgtcggcgc gtcggatctg tttttatccg tctgggccgc cattcgctgg 763921 ggtgtcagcc cgcttgtgct tttgattgtt ttttccgcgc tgtatgtgat tgcgccgaac 763981 aaaaagctgt ctctccggtt tgtcatgccg ggtgcggtct ttgcgactat cggctggatc 764041 attgtcagca cattgttttc attttacgtc agcacgtttg cgaactatag cgccacttac 764101 gggagcatcg ggggaatcat cgttctgatg atttggtttt acttgagcgg cattttaatt 764161 atcctaggcg gagaaatcaa cgctctttta cataaacgta aaaagcttcc tgatgaaaat 764221 ccctaccatt agcgcaccct ataaacgaac ttcggttcaa aaagaagtcg gggggatatc 764281 gtgatgacca agcatacgaa aaaaggcgga agccataaca aacaaaactc gaaaagcaaa 764341 tcgagccata aaacaagcgg aagcgccaac ggacaaaacg gctaccatta gcataaaagc 764401 ctcctgacat gatgtcggga ggctttttga ttaagaagat gaagaatagg tttcagccgg 764461 tgaccagctt ttcggtttgc ccagcacaag ggccagccac acagagctaa gcgtgagagt 764521 aatgaagtag aacaagtttg cgctttcaaa tgtctgcata taccagccgc cggcaactgg 764581 gccgaggatg ctaccgagac tgaatgtaat gccgcaaagc aggtttcccg ccggcaggag 764641 gtgaggcgga agaaggtctg tcatatagct gatgccaagt gtaaaggttg atccgactgc 764701 cattcctgca ataaaaaagc agccgccgat cacgtagggc gaaggaaata caccggcgat 764761 gaaaaagcaa agagccccag tcagtaaaat caccagcagc acattccgcc tgccgtattt 764821 atcgctgagg atgccgagcg gaaactgaaa gataatgctt ccaatcgcaa atgcgggaag 764881 gatgatcgct actgcgtcta ctgatatccc caaacggagc gcgtacaccg gaaagcttcc 764941 gttcagcgcc gtttccagaa agccatagcc aaatgtaggc ataaaggcaa cccacccaaa 765001 cagcatggcc tgataaaatc gcctgaaact attgtctgat ttggtttcat gaggactggt 765061 ttccgggtat gcattttgta gaaagaaaac aaaaagccac gcaaacagac tgatgcagcc 765121 ggacacgata aaaggaagcg acggactcag cttgacaagc ggcaccatga acgggcctgc 765181 ggcaaagcca aggccaaagg aaagcccata aatagacagg tttcttccgc gattttgttt 765241 tgatgacatg gaggtcaccc acgtttgcgt agaaaagtga agcatgtggt cgccgattcc 765301 aatgaacagg cgaagcagga accagaccca aactgactga agccaaataa atccgaataa 765361 gcttaaaatg acaatgcttc cgcccatgac gatcagcggc ttgaacccga gctttctgag 765421 cggtgcttcc ataaacggcg aagccaaaag cacaccgata tacagcccgg tcgcgtgcag 765481 gccgttgata gcagcggatt ctccatttgt ttcaaaaatg attgaaatga caggcagcag 765541 catgccttgt gaaaacccgg aaatggaaac gagcaagaca aggataaaga aatgaaatcg 765601 tgacatcgtg tcagttctcc ttatatggaa tctatgttga tcgtacaacg ttttccaaaa 765661 gcaggcaacc tgaaaaaagc ctatatcacg ctatacattt gccctcgtgt aatcatgaag 765721 gtttttgtga agaataaaaa taaaacaagt cataaaaaag gagctatttc accatgaatc 765781 gtatcttttt tattttagtg gcggccggtg ttccgctttc tgtgattggc agtttgatgc 765841 attggccttc cgcggttcta tttgcagttt attgcgtgac gattatcgcg cttgcaagct 765901 atatggggag ggcgacagaa tcactgtcca tcattgcagg accgcgtatc ggcggtttgt 765961 tgaatgcaac cttcgggaat gcggtggagc tgattatttc cctttttgca ttaaaagaag 766021 gcctgacagg aatcgtgctt gcctctttaa ccggttcagt gctggggaac ctgttgctgg 766081 tagcgggcct atcgtttttt gtcggcggtt taaaatataa gcggcaggaa tttaatatcc 766141 atgatgcccg ccataactcc gggcttctga tttttgccat cattgtcgcc tttgtgattc 766201 cggaggtatt ctctgttggt atgggaaacg ccagcaagct caatttaagc atcggcatca 766261 gcatcattat gattctgtta tatgtggcgg cgctgtactt taaacttgtc acgcatcggg 766321 gcgtttatca gccgaataat gccgctcaga ctgaagaaga ggaagagcca gaatggtcag 766381 ggaaggttgc gacgattgtc ttgtttgcgg caacgattgt ggttgcatac atatccgaaa 766441 acctggtcca tacctttcac tcggtggctg aacagttcgg gtggagcgag ctgtttattg 766501 gggtcatcat cgtggcgatt gtaggaaatg cggcggagca tgcgtcagcg attattatgg 766561 ccttcaaaaa taaaatggac attgctgttg aaattgcagt aggctctacg ctgcagatcg 766621 ctatgtttgt cgcaccggtt ctcgtcatct gttctatctt ttttccgaca agcatgccgc 766681 ttgtatttac attgcctgag ctcgtcgcga tggtatcagc ggttctcttg atgatcgcga 766741 tttcgaatga cggggattcc aactggtttg aaggggcgac actgcttgct gcatatgtca 766801 ttatggcgat cggctttttc cttctttaac ctgaaaaaat gatggataac aacaaagcgg 766861 gatgaaaaga ctaagggaaa atgccataga aagagtgata tgatgaaaaa gctatttcat 766921 tccacactta ttgtgttgtt attctttagt tttttcggcg ttcagcccat ccacgcgaaa 766981 aagcagttta aggttcctaa ttctgtcgca agcatttcaa aggaaaacac gtatccgaat 767041 gcttcacagg atcagccaat gcttcagccg agcaagctgg caaaggaatt gctcgatcat 767101 tctgaggtaa agattgaaaa tccgcatctc atcaaaatgc tgaatgaatc caacatatcc 767161 ggcacaccgc ttgcagtagg gtaccgggcg acaatatttc tcgggaaatg ggcgctcggc 767221 tatgaatcaa atgaaacagt cgcaaactgg gaatataaaa aaatcaatac aaaccgtgcg 767281 gataaccgcg gcgggaaaga aacggctgaa atgcattatg cccaggaaca gcagtacaga 767341 gtgaagggcg gcttgacagc taaagttcca aatgctgaag atgtcaaaag catgatgatg 767401 caaaaagcaa tgaagaaaac gaacctcccg cttgcatttg agacggtcat cggggctggc 767461 acaaaacggg atcagattta taaagtcgct cctaaaaaaa tcggttatct acatgcatat 767521 gcaccggctg tgaatgaaaa aggaaaagtg acttacggag aagtgtactt agtgctgaaa 767581 ggaaataaac gaaaactcgt cgtgaaaaat gtcacgtcac agggaatcgg cgcgtggatt 767641 ccggttcaag atcatgtcac gtttggcttt cagctttcct cactgccaag ataaataaaa 767701 aactgattcc aactcggaat cagttttttt gtttattggg ttctctcgat tcggaccgct 767761 tcctcaagca tttgcacatt gttttggtag agctggcgaa cgagaacccg tcttactgca 767821 aggctggcac tgaaataatc atcatctttc accatgcctt taaccgtaaa ttcgacgccg 767881 cgattgattt tattcaatgc ggtgatgccg tggatttgaa acggttctgt cggattgccg 767941 aattcatccc gcttcaatga atcacgaagc tcttcattca gcatgtcaca tgcctcttcc 768001 aacacgctgt acacgcggtc cggatcttct ttaaagctga taagaaagga ttcggtaatc 768061 cgcataaaat caatattata gttctctatt tgtctgacct cgccgttgct gatggtgagc 768121 agcttcccgc tccattcccg gatttgcagc gagcggaggc cgatttcctc cactgtcccg 768181 ttgaacaagt tgttgacggt gacataatcg cctttgtgca gctggcgttc atatattaag 768241 aatacaccag ccagcacatc tttgatcagc gattgggcgc caaaaccgat cacgatacct 768301 gctacgcccg ccccggccaa tatcttgccg aaatcatgca caaataaaga aataacgtaa 768361 aagataaaac caattgttgc cgtatactgg gtgacagaac ggacaaggct ttcaatcgtt 768421 ttttcctttt tttcttcaat aaagtccgtc cgtttaaaaa atagctgtac cagccggttg 768481 atgataaaga caccgatcca aaggataacg gcaacgagga gaatatcgac gattttattt 768541 tgaaaaatct ccgtaagtgt ttctttcatc cgcatctaac tcctggcttg acgttttgtg 768601 aagtctgtat cctgataata actgtttttg acaagaacat tcggtccgag gcaccggaca 768661 ttcgggcagt ggcaactcag ttctttcgca agcttggtct ctctccactt ttcataggcg 768721 gaagggaggc tgtccgtctg aatgttgcca agcggcgggg tatcaccgaa atcggtcacg 768781 ataatgtttc cgtcgaaaat gttcacattc aggcgggatc ggccgtcagg gtcatttcgc 768841 actgtgacgt ttttcgccgc gcgaagccgg cgaagcagct tttggtcgtc ttcgtccgga 768901 ctgcaggcat aaaacggcag cgttccgaac agcatccacg tattttcatc acgaatatcc 768961 agcaagcggt gaatggcctg tctcatctct ttcaggctga gggattcaag agcgcttgcg 769021 aaatcgcttg gatacattgg gtggacctcg tgacgctgac atttcatatc ttctgtgatt 769081 tggcggtgaa tatgctcaat atgcggaagt gttcgtttgt tcagcatcgt ttccgcagat 769141 accattactc cggcatccac gagcgtgcgg ctgttttcga tcattttttc aaaatagcgc 769201 gcgcgctgtt cgaaggtcgg ttttctgtcc atcatggcaa agccgatttc agcaaaatct 769261 tcaactgttc cccagttatg tgaaatatgt agcacatcga gatacggaat gatccattcg 769321 taccgctcga tgtcgagggt cagatttgaa ttaatttgtg tccgcacacc ccgttcatgg 769381 gcatatttca ataaaggaac aacatattct tttactgatt tcaacgaaag catcggctct 769441 ccgcctgtga tgctgatgga tctgaggcgc gggatttcct ccagccgttt taacagaaga 769501 tctattggca gagcattcgg gtctttaggc tgcaatgtat agcctacagc acaatgctcg 769561 catctcatat tgcacagtgt cgttgttgtg aattcaacgt ttgtcagctg catgtctccg 769621 tattggtcaa catccatata ggcttcccaa gggtcaaact cgggcgtaat cggacgcagc 769681 ttcgtgtttt gtgtcatgac tatctaactc ctttataaat gggcatacta acgctgccaa 769741 cagttaattt tagacctgat ttgccaagat cgcaagtagc gcggcgattg aaaaacggca 769801 aaaaatgagc taccataata aaaaatgaat ggaggaacag aatggggaac gccgtaaaca 769861 ataaagatca gcagattgat tatttaaaga acagacttga catgtttatg aacgtcatcg 769921 attcattaga ccctgaagca accgacgttg aagatataga caggcttatc agcatgcttg 769981 atgacctgga agccaaatac gaacgtttta aaaaagattg ggaataaaac cgcgtgcccg 770041 ccgcggtttt tttattggca taaagcaaca gtataaaaca aagtctctat ctgtaaaata 770101 agaaaaaatg cagaaggagc gctggccatg aagtggatgt gttcaatatg ctgcgccgcc 770161 gtattgcttg ccggaggtgc agcacaggcg gaagcggtgc cgaatgagcc gattaattgg 770221 ggctttaaac gaagtgtcaa tcatcagccg ccagatgccg ggaagcagct gaacagttta 770281 attgaaaaat atgacgcgtt ttatttaggg aatacaaagg aaaaaacgat ttacttaacg 770341 tttgataacg gatatgaaaa tggctatacg ccaaaagtgc ttgatgtctt aaaaaaacat 770401 cgcgtaacag gaacgttttt tgtcaccggg catttcgtaa aggaccagcc tcagctgatc 770461 aaacgaatgt cagatgaggg ccatattatc ggcaatcatt cctttcacca tccggattta 770521 acgacaaaaa cagctgatca gattcaggat gaacttgatt cagtcaacga agaggtttat 770581 aaaattacgg gaaagcagga caacctgtat ttgcgtccgc cgcgcggcgt gttcagtgag 770641 tacgtactga aagaaacgaa acgcctcggc tatcaaaccg ttttctggtc ggtcgctttt 770701 gttgattgga aaatcaacaa ccaaaaggga aagaaatatg cctacgatca tatgatcaag 770761 caggcgcacc cgggagccat ttacctgctt cacaccgtat cgagggacaa tgcagaagcg 770821 ctggatgacg cgattacaga tctgaaaaaa cagggctaca cttttaaaag cattgatgat 770881 ctgatgtttg agaaagaaat gaggctgccg tctttgtaaa agagaaagac ctctccttaa 770941 acggagaggc ttttctttat tttatacatt taatcagtgc ggcccagtcc agatccccga 771001 agcctttctc aatcccgctt tcaaaatggc tcttggccag ctcggcaaga ggaagatttg 771061 cagaaacccg ttttgcggcg gcgagtgcca ggttggtatc cttcagccct aaagacattt 771121 tgaagccggc cggctcaaat ttctgctcgg ccataatggt tccgtaattt tgatagactg 771181 gagaaccaaa gagcgcgctg gcgatttcta aaaattgttt ttgttctaag ccgtatttct 771241 ccatcattaa aaaggattca gataacgcct ccagcatgga cacaagcaag aaattaatgc 771301 tgattttggc tgcatttgcc gtcttgcttt cttcgccgac gtcaaatatc tgctggctca 771361 ggctgtcgag cagaggcttg gcagcttgct ttgcttccgc cggtccggct gttatgatac 771421 ggagcgcggc tttggctgcg gcatccggtc tgccaaggac aggagcggcg agaaaaaatt 771481 gtcctttctc tgcatgagcc gctgcgagct tttctgagaa ctcaacactg attgtgctca 771541 tcgagatgtg tatgccgttc tctgctaatc cttcaagcag cccgtcttct ccgaatgtca 771601 cggtgctgac agaatcatca tctgcaagca ttgtgatgac aatatcagcg gactttgccg 771661 ccagccgcgg cgtatcagct gcctgtgcgc cttctgtgac aaggtcttct gtcttttgtt 771721 tcgtccggtt atagacagtc aattcgtagc ctgcttgaag aacatttcgg gcaatgggct 771781 gtcccatatt gccgagtccg atgacagcaa ttttcaatct aatcactccc tgaatatttt 771841 ttccattata aacaatatga acagaatatg catagcgatc ggcttacaac aaaaaagaac 771901 agctgctcgc tgtcctcatt taaaaatatt gaaccatcct ttatgtacaa accaaatcag 771961 cattccaatc acaagcgcgg ccatcaggcc aagtacagcg aaatatccgt atttccaatg 772021 cagctccggc ataaagtcga agttcatacc gtatacaccg gcaataaagg tgagcgggat 772081 gaaaatggtt gatacgatcg tcagtgtcat cataatcgca ttcatccggt ttgagtttag 772141 cgtcacgtag ctgtcacgca agtcggacgt catgtcacgg ttggattcca caatttcaga 772201 caactttaac aaatgatcat atatgtcgct gaaataggct ttcgtttccc gctgctcttt 772261 cacatggtca aggcttaaaa tccggtagag caaatcacgc atcgggataa tcgtccgtct 772321 caaatgcaat aggtctgttc tgagatcaaa cacctcgttc atcagcgttc catacgtttt 772381 gtggggacgg ctttcttcaa tttcattcag ccggtcttca attttataca cgagaggaaa 772441 atattcatca acaagctgat ccatgatcat ataagaaata tgcccgggcc cttttttcaa 772501 tatgtccggt gaagcataca aacgctcccg gactttagcg ataccgggcg tttcgtgtaa 772561 atgaaaggtg acgacaaatt tttcgccttg aaagatatcg acttcctccg tctcaagtgt 772621 ttccttattc agcgcatgaa tcacgtaaaa acgatagccg tcataatggt caagctttgg 772681 ccgctgcata tgctggaagc aatcctcaat ggcaagcggg tgaaaatgaa aaaaatctct 772741 caataacgcc gtttccgtat cctccgggcc gtaaaaatca acccagtacc atgcaatatc 772801 aggctgttcc actcgttcga tcggtatatt tttcagcagc tgatgctctg ttgtgattgc 772861 ggtaatgttg atcataaaca accctccacc tgccattata tcatgcggtc tttatgagaa 772921 aagtatacgg tactctctgc ctaattccag cggcatgtta tactgaacaa aaacggaaaa 772981 aagggtggat ctcatgtgga aggaaaaagt atctgtcacg cctccgtatc attttgaccg 773041 cgtgctggac aggctgtctt tagaccccct caatgctgtt gatcgagagg cgagggaagt 773101 ccgtgtgcca atcagaaatc aagcggggga cgtatgtatt gtaaaggtac aggcgttagg 773161 ccatgcgggc gagcctgagt tcctcgtcag cggggaaacg gatcagggag aaatgatgaa 773221 ggaaatcaag cggatttttc aatgggaaaa tcatttgcag cacgttctgg atcatttttc 773281 aaaaacgagc ctgtccgcca tttttgaaga gcatgccggg acgccgcttg ttctggacta 773341 cagcgtgtac aactgcatga tgaaatgcat tatccaccag cagcttaatc tttccttcgc 773401 ttacacgcta acagaacggt ttgttcatgc gtttggcgag cagaaggatg gcgtgtggtg 773461 ctatccaaag ccggaaacga ttgcggaact cgattatcag gatctgcgtg atctgcaatt 773521 cagcatgaga aaagcggaat acaccattga tacatcaagg atgatcgcag aaggcacact 773581 cagcttgtca gagctgccgc atatggcgga tgaagacatt atgaagaaac tgatcaaaat 773641 caggggtatc ggcccgtgga ccgtgcaaaa cgtcctcatg ttcggacttg gccgtcccaa 773701 tttattcccg cttgccgata tcggcctcca gaatgccatc aaacgccact ttcagctgga 773761 cgataagccg gcaaaggatg tcatgctggc gatgagcaag gagtgggagc cttatttaag 773821 ctatgcgtct ttgtatttgt ggaggagtat agaataattc gtctgacaat gaaggaaatc 773881 ctgcaaacgt gttatactag aaagatgtga aaaaaccatt tcactttctg ccatccgcag 773941 aaagcttcat atagaaacgg agagaacaac gtgaaccaac aaaagaaaca ggcgcccgtc 774001 gaactgaagg tcggacaaac ttttccgctg acgattaagc gtctcggcat taacggagaa 774061 ggtgttggct attttaagaa aaaagtcgtc ttcgtgcccg gcgcgcttcc tggcgaagaa 774121 gttgttgtgc aggccacaaa ggtccagccg aagttttcgg agggccgcat taagaaaatc 774181 cgcaaggcat ctgagcaccg ggtggcaccg ccttgccctg tttatgaaca atgcggcggc 774241 tgtcagcttc agcaccttgc atacagccag cagcttcggg aaaaacgtga tatcgtcatt 774301 cagtctcttg aacgccatac gaagtttaaa gttgaaaaca tggaaatcaa agaaacgatt 774361 ggcatggaca acccgtggaa ttaccgcaat aaaagccaat tccagatcgg gcgctcgcaa 774421 agcggcagca tcatcgccgg cttatacggc cttgattctc atgatatcgt gccgattaaa 774481 gactgtatcg ttcagcatcc ggcaacgaac aaaacaacag gcatcgtccg ccgcatttta 774541 gaggacttca atgtgtctgt ttataatgaa agaaaacgaa aaggcgacgt tcgcacgatc 774601 gtgacgagag tcggctttga aacaggcgaa gtgcaggtcg tgcttgtaac cgcaaaagaa 774661 acgcttccgc acaaggaaga aatcgtcaaa gcgattcaaa agcgattgcc agaggtcaaa 774721 tccattattc agaatgtaaa cggggcgaaa acctcagtga tttttggtga gaaaacaaaa 774781 cagctcgccg gaaaaacagt gattcaagaa gtgctcggcg acgtatcttt tgaattgagc 774841 gcccgcgctt tcttccagct caatccggaa cagaccgtca agctgtatga tgaagtgaaa 774901 aaagcggcgc agctgaccgg aaaagaaaaa gtcgttgatg cgtattgcgg cgtcggcact 774961 atcggcatgt gggttgcgga cggagcgaag gaagtccgcg gcatggacgt catcaaggaa 775021 tcaattgacg atgctaagaa aaacgccaaa aaacacggca tggcaaatgc cacatacgta 775081 acaggaacag ccgagcactg gctcccgaaa tggacgaaag aaggcttccg cccggacgtc 775141 gtcattgtag acccgccaag aacgggctgt gacagcacgt tcttggacac gatcaaaaaa 775201 gtcaaaccga aacgctttgt ctacgtttcc tgcaatccat ccacgcttgc gaaagatttg 775261 cagacgctgt cgaaggacta tcgcgtggac tatattcagc ctgtcgatat gtttccgcag 775321 acggcgcatg ttgaagcagt ggcgaggctt gtattaaaat cgtctaacta aaaagaacat 775381 ttcccagtca taaaatagtt ttcctaataa gacctggatt tcggtaaaat aaacaattcc 775441 gatttccggg tctttttcgt gcgcagctct tgtcctaacg gtctgttctc aattttatct 775501 tccttctttt cgcggagatc tttattttaa ctggcgaaaa gaattgaaaa aacgtgttga 775561 aaagcaggtg aaaaaaagcg ttatttaacc ggaaaaatat cctcccagta tgtttaaaat 775621 acatgagtag aatgatgtaa aatcatagat gtattttcat aatttgtaaa attatatatt 775681 gacttgcagt tattacgtgt gaaatattga tgataggaat ataaggaaag tatggcgtat 775741 atcatttcaa gagtcattcg atgtaaaaag ttgaaacatt gtaataaatg aaagaggtga 775801 aaatgatggc caaccccatt ttaaaatgca taacgtatga gcactacaac aattaaataa 775861 tagtgccgag acgataacaa ctattacagt aatacctaca atggttatat ccttgcgaca 775921 atcatgcttc ataatataat gattttagat tgacacttgg ctaaaaagta ttgcagagaa 775981 ggaaatggat aattaaatgg ataaagtata taaaagaagt tggtttcaaa catttttggc 776041 atttttagta tctcagcttt attttaattt tgtagaatta acgggatggg gtcctaagta 776101 tagagaaatg aatggattcc cagcaaacat agttgaacta gatttctttc aaacatatct 776161 ttcattctat gataatccat ggtttaatat tattactgtt ttcttgggag ttttcactat 776221 tatacaaata attacaggga taacaaagga tattcgaaat taaagcaata acttctgatg 776281 ccttatttaa tgatgaaaga aaatgtacac tttcttaatt atcttatgag tgaagactgc 776341 gacacttagt cagcagtcta ttttatggtt ctggatcagg attaccgaat tataacccta 776401 tacaaatata tagtaggttg ccacttgctg cgttggttat tttctaaatc atgagcaaat 776461 cccaaatgat tcagattgaa gttcttgaat tcttttaaat aagggtttat tttctcttct 776521 catcctcttt actccatgtg attcacaagt ggtagcagct taagtaggtt ttttcattct 776581 cttgagtact cagttatacc acccccaact caatttgctt tatctctatt agtttttccg 776641 caaatatgat atagagatac ggatatggtg tagtgttaaa tatcttatct tcaataacag 776701 ggcaattatt ttgcgttggt aatatggaga actcatatga tattctattt aggttggaat 776761 cctttttatc caaaaagttc aaaagcaagg ccactaagaa agacgaaggt cagcgccagt 776821 taaccagaat ataaaaaata gggtagataa tcatcccacg tgaaatcttc aaaatttact 776881 atagattgat aagaaatgct ttcgcatgcg ataagtgtaa aagaagcatg gtcagttttt 776941 aatttgggat aaaggttcag ccgtatccca taatgaaagg atttgatttt tgttatgaca 777001 gaaaatttct ggcgtgaatt accacggccg ttttttgtac tggcaccaat ggaagatgtg 777061 acagatgttg ttttccggca tgtagtaagt gaagcaggca gaccggatgt gttttttaca 777121 gagttcacaa actcagagag ctattgccac ccggatggga aggatagcgt gcgcggccgt 777181 ttgactttta cagaggatga acagccaatt gtggcccata tatggggaga taagcctgaa 777241 aacttccgta aaatgagtat tggcatggca gagttaggat ttaaaggact agatatcaat 777301 atgggctgcc ctgtgcctaa tgtggcgggg aatggaaagg gaagcggcct tatttgccgt 777361 cctgcagttg cggcagaatt aatacaagct gcaaaagcag ggggattgcc tgtaagcgtg 777421 aagacaagac ttggatacac ggatgtggat gaatggcgcg agtggctgac acacattttg 777481 aaacaggata ttgcgaatct ttctattcat ctgcgtacaa gggcagaaat gagcaaagta 777541 gatgcgcatt gggagctcat cccagagatt aagaaacttc gtgacgaggt ggcaccagat 777601 acattgctaa caataaacgg ggatattcct gaccgtcaaa ctggcttgaa acttgctgaa 777661 caatacggcg tcgatggaat tatgataggg cgcggtattt ttacaaatcc tttcgctttt 777721 gaaaaggagc cgaaagagca tagcagcaag gaattgcttg atctcttaag gctgcatctg 777781 gatctccatg atgaatattc aaaagaagaa gcccgtccat acaagcctct tcctcgcttt 777841 ttcaagattt atctccgcgg attccgaggg gcaagtgaat taagaaatca atgcatgaac 777901 acaaagtcaa cagatgaagt gcgtgcattg ctcgacgact ttgagagaaa gtatcttgat 777961 gggatagagt aacagcagtg cttgattcaa aaaaggctaa caaaataaag ggatttttac 778021 acaattcttg actaaaataa acctggattt tcggtaaatc cgggtctttt ttgtacgcag 778081 cttttactca gcctgtcttt tctctaattt attgtaagaa aataatggta tatttagtgg 778141 agatatcata taaaggggga gaggaaaatg aaacggctat gcatcatccc ctgcggcaag 778201 aaaaaaatct gggatgtcca gcctgatgcc gggccggtaa gagcagagga cgcttatctc 778261 agcccgtttc atcaggcgtg cgagcggtat gcaaaaacat ttttcgatga gtgggtgatt 778321 ttgtcggcga agcacgggtt cctccgccct gatgatctcg tttcgggaaa ttacgatgtc 778381 acttttggca ccggtcatcc ggaaatcatg acagcggacg agctgcgccg tcaatttcac 778441 gaaaaaggct tttctgatat cgaagagcta gtcatgcttg gcggaaaaaa atatcgaagc 778501 gttctaaacg ccgtcatcgg agaacaccag catatcagct ggccgctatc atcatacaaa 778561 ggcataggct atatgctcca agcgctgaac cgggctgttg aagaaaagca tgaactgtag 778621 cacgtacata tgaggaaaag agtgggaaca tgaaaaaact tgtgtttggc ttgcttgcca 778681 ttgtgttatt cggatgcgga ctatatatct atcatgtatg gttcggtgat ccattttcga 778741 aaaatgctgc agaacagaag ctagtgtctt atgtgaaaca aacctatcct aagaaagaaa 778801 tcaagatcac gaatggggta tataacgcta aaacgtctga atatgtattt gaagcaacct 778861 cccaatctca tcgctaccca atgtgtacga agggatttct gcatcctaaa gtaacgtgcg 778921 atggaattga agaagcgtat accgaatcag tagcaaaaca tgtaaatgaa gaagcaacga 778981 aggcaatcga agcagatctg aaaaaagcgg ttcctcgatt tataaaagct gatgctgctt 779041 tgagtatcga aaacggacag ttcacgttag atacaaaatg gaacaaaaag ctggctgaaa 779101 aagcgcctat gagcatgacg attcagttag acgccagcgg gttatcaaaa acagatgccg 779161 caaagatggc ggaaacggtc agaaaaacgc ttaatgaaaa gggatataca tactcaaacg 779221 gcacgataga ctgtatgcag aaggacgggg acggcggtat tggatatgtc aaatattcaa 779281 ttgattttct ttcaaaagca gctattcagt caaacgatgc agaggaacta ggaagttaaa 779341 aagatttcca aggaaataaa tacgtcgatc attgtcaaag gccgggtgat atccggtctt 779401 ttttttgcat gctgtaaaac gagacaaatg aatcagtttg agacaaaacg agacacacgt 779461 ctcaaactgt ctccaaagtg aagatgagaa gactgatttt acgggctcaa aagactggca 779521 cacttcttgc atttataatg gtgaacccta aatagaagga ggcgcacaaa atgaaattgt 779581 taaaacgaga aggcttgtca ttaactgagg aaaaagcgct gtggatgtac caaaagatgc 779641 tggagatcag gggctttgaa gacaaagtgc atgaactgtt cgcccaggga gtgcttcccg 779701 gattcgttca tttatatgcc ggtgaggaag ccgtggctgt aggggtgtgc gctcatttac 779761 atgatggcga cagcattaca agcacccaca ggggacatgg acattgtatc gccaaaggct 779821 gtgacctgga cggcatgatg gcggaaattt tcgggaaagc gaccggattg tgcaaaggca 779881 agggcggttc tatgcacatt gcggatcttg ataaaggcat gttaggcgca aatggaatcg 779941 tcgggggcgg ctttacgctc gcatgcggat cagcgctcac ggctaaatat aaacagacta 780001 aaaatgtaag cgtttgcttt ttcggggacg gggcaaataa ccaaggtacc ttccacgaag 780061 ggctgaattt agcggctgta tggaaccttc ctgtcgtatt tgttgctgaa aacaacggct 780121 atggcgaagc taccccattt gagtacgcat cagcctgtga ttcaatcgcc gatcgggcgg 780181 ctgcttataa catgccgggg gttacagttg acggcaaaga tattttagca gtttaccagg 780241 cagccgagga agcgatagaa agagcaagaa acggcggcgg cccgtctttg attgaatgta 780301 tgacctacag aaactacggc catttcgaag gagatgccca aacctataaa acgaaggatg 780361 aaagagttga gcaccttgaa gaaaaagatg ccattcaagg ttttaaaaac taccttttaa 780421 aagaaacaga tgctaataag ctgtcagaca ttgaacagcg tgtcagcgaa tcgattgaaa 780481 aagccgtctc gttcagcgaa gacagcccat atccaaaaga ttcggagctg ctgacagatg 780541 tgtatgtgtc atatgaaaaa ggaggaatgt aagagatggc gagagtcata agcatgtcag 780601 acgcgatcaa tgaagcaatg aagcttgcga tgagaaaaga cgaaaatgtg cttttgatcg 780661 gtgaggatgt cgccggggga gcggcggtcg atcatttgca ggatgatgaa gcatggggcg 780721 gtgtattagg ggtcacaaag ggactcgtac aggaattcgg gcgtacaaga gtgctggaca 780781 ctccgatttc tgaggcaggc tatatgggag cggctatggc tgcggcatca accggtttga 780841 gaccgattgc cgagctgatg tttaacgatt ttatcggcac gtgctttgat caggtgatca 780901 accaaggggc gaaattccgt tatatgttcg gcggaaaagc gcaagtgccg attaccgtcc 780961 gcaccacata cggagcaggg ttccgggccg ctgcccagca ttcacaatcg ctgtatggcc 781021 ttttcacgag catccctgga ctgaagacag ttgttccatc caatccgtat gatgccaaag 781081 gtcttttgct tgcagcaata gaagataatg atccggtgtt tttctttgaa gacaaaacgt 781141 cctacaacat gaagggcgag gtgccggaag attattatac aattcccctc ggaaaagcgg 781201 atatcaaacg cgaaggcaat gatgttacgc tctttgcagt cggcaagcag gtcaatactg 781261 cgcttgaagc ggctgcacag ctttcagaga ggggcatcga agccgaggtc cttgatcccc 781321 gcagtctgtc tcctctggat gaggatgcga ttttcacatc gttagaaaaa acaaaccggc 781381 tgatcatcat tgatgaagcc aatccgcgat gcagcattgc cacggatatt gctgcgcttg 781441 tcgctgacaa gggctttgat ttgcttgatg cgccgattaa acggattaca gcgccgcata 781501 caccggttcc gttttcacca gtgcttgaag atcaatattt gccgacacca gataaaattg 781561 tcagcgtcac gcttgaattg cttggcgagc cggcattgaa ttaaaggggg gacacaaatg 781621 gcggtaaaag tagtgatgcc aaaattggga atggccatga aacaagggga agtatcgata 781681 tggaataaaa aagtaggcga cccggttgaa aagggagaaa gcattgccag cattcaatcg 781741 gagaaaattg aaatggagat cgaagcgcct gaaaaaggaa cgctgatcga tatcaaagtg 781801 aaagagggag aagaggttcc gcccggcaca gctatctgct atatcgggga cgccaatgag 781861 tcggtgcagg aagaggcggg ggcgcctgtt gctgaagaca atatgccgca agccgtccag 781921 cccgtcaaac aagaaaacaa acccgcagcc tccaaaaaag atcgaatgaa aatatctcca 781981 gtcgccagga aaatagcaga aaaagcagga ttagacctaa aacaactgaa aggaactgga 782041 ccaggcggac gaatcgtgaa ggatgacgta acaaaggctc ttgctgaaca gaaaaaagat 782101 caagcaaagc ctgtttcgga gcagaaagcg caggaaatcc cggtgacagg catgagaaag 782161 gtcatcgctg cccgaatgca ggaaagcctg gcaaacagcg cgcagctgac gatcacgatg 782221 aaagctgata tcaccaagct tgccactctt caaaaacagc tttcaccaac tgcggaagag 782281 agatacggca caaaactgac gatcactcat tttgtctcaa gagccgccgt tctcgctctg 782341 caagctcacc ctgtgctgaa cagcttttat caaaatgagc gcatcatcac acatccccat 782401 gtgcaccttg gtatggctgt agccttggaa aatggcttag tggtgcctgt catccgccat 782461 gctgaaaagc tatcgctgat tgaactggct caatccatct cagaaaatgc caaaaaagca 782521 cgcgagggac gtgcgggaag cgaagaactg caaggatcta ctttctccat tacaaacctt 782581 ggcgcgtttg gagttgagca tttcacaccg atactaaatc cgccggaaac aggcattctc 782641 ggcatcggag caagctatga cacaccggtg tatcaagggg aggagatcgt cagaagcacg 782701 atcctgccac tcagcctgac atttgatcac agagcgtgtg acggcgcccc tgccgctgca 782761 ttcctgaagg cgatgaaaac atatttggaa gaacccgcag cattaatttt ataggaaaag 782821 caggtgaaaa cgacatgaca ttagccatta tcggcggcgg acctgcaggc tatgcggctg 782881 cggtttccgc ggcacagcag ggcagaaacg tgctgctcat tgacaaaggc aagcttgggg 782941 ggacctgcct gaatgaaggc tgcatcccga caaagtcttt gttagaaagc gcaaacgttc 783001 ttgataaaat caagcatgcc gacagctttg gaatcgaact tccggcaggt gcgatatcag 783061 tcgattggag taaaatgcaa agccgaaaac aacaggttgt cagtcagctt gtccaaggcg 783121 ttcagtacct aatgaagaaa aatcaaatac aggttgtaaa gggaacagcc tcctttcttt 783181 ctgaaagaaa gctcttgatc gaaggagaaa acggaaaaga aatcagagag gcggaccaag 783241 tattgattgc ctccgggtca gagccaatcg agctgccttt tgccccattt gacggcgaat 783301 ggatcctcga cagcaaagac gcgctttctc tttccgagat tccgtcttca ctagtcattg 783361 tcggcggcgg tgtcatcggg tgtgagtatg cagggctgtt cgccagattg ggatcgcagg 783421 tgaccatcat tgaaacagcg gaccggctga tcccggctga agatgaagat attgcccgtc 783481 tctttcagga gaaacttgag gaagacggtg tcgaagtgca tacttcatcc agattagggc 783541 gggtggatca aacggccaaa acggcaatat ggaaaagcgg tcagcgagag tttaaaacga 783601 aggccgatta tgtgctggtg gcgatcggca gaaaaccccg tcttgacgga ttgcagctgg 783661 aacaggccgg agttgatttt tctccaaagg gcattccggt gaatgggcac atgcagacga 783721 acgtgcctca tatttacgcg tgcggagatg ctataggggg cattcagctc gcgcatgccg 783781 ctttccatga gggcatcatc gctgcttctc atgcttccgg aagggatgtc aaaatcaatg 783841 agaaacatgt gccgcgctgc atctatacgt ccccggaaat cgcgtgtatc ggaatgacag 783901 aacgacaggc aagaagcata tacggggatg tgaagatcgg cgaattttca ttttccgcaa 783961 acggcaaggc gctcattaaa cagcaagcgg aaggaaaggt caaaatcatg gctgaaccgg 784021 aattcggcga aatcgtgggt gtctcgatga ttggcccgga tgtaaccgag ctcatcggcc 784081 aagcggcagc gatcatgaat ggtgagatga cggcagatat ggcggagcat tttatcgccg 784141 cccatccgac tttatcggaa acattgcatg aggcgctgtt aagcacgatc ggccttgcgg 784201 tacatgcata ataaaggaaa aagcaggcgc atggatataa ggcgcctgct tttttattgt 784261 tgaaagcgct ttatttttcc cctacaatag atgaaaacgg cgtgtaaggg aggagcgatc 784321 aaggaaatga attcggtccc aaacgatttg caaacctgga aacgttttgt gaaagacggt 784381 gtgcttgacg aagcccgatt aagaaaacgg attgcagagt catggcatcg ctgcaaaaaa 784441 gctgaggtca atccttattt agaaaaaggc ccgaaggttt tacagcaaac ggagctggat 784501 cagcagtcaa aaaaacattc attcttcttg acgaccgcaa agccttacct cgaaaaactg 784561 ctgcctgcca taaaagaaat ggaaatgatg gcgctgttaa ttgattcaga cggtgttgtt 784621 ctggcattgg acggccatcc gcgcgcgctc tatgaagcca aacgcatcaa tttcgtcgaa 784681 ggggcatgct ggacagaaac ggctgtcgga acaaatgcga ttggcacggc gctccacatc 784741 agcgagccgg ttgcaataca aggatcagag cattactcta tcgcttccca tctttggaac 784801 tgttcagctg ctccgattca ccatgaggat ggcagccttg cgggtgtaat tgacatatca 784861 tgcccggcgg caggcgcgca tcctcatatg cttggtattg ccacggcgat tgcctatgcc 784921 gctgaacggg aactcgcagc taaaagccgt gagaaagagc tggagctgat cagccgtttt 784981 ggggagagag ctgcatccag tgtgccgatg gtgctctgta ataccaagca gcacatcatc 785041 agtgcgagca tgccgattcg aacctcaatg ccggattggc agggccggca cctgtacgag 785101 ttgaaggaac ggggctattc aatcgaaaat gctgtcacca taggagatgg cggcacttgt 785161 ttttatcttt cggaacaaaa gaaaaagaag gcgtttcgat tcaatggagt gatcgggcaa 785221 agcggccgat cgcaagcgat gctgatgcac cttgaacgag cagctgcgac ggatgcatcg 785281 gtctgtttgt cgggtgaaac gggtacgggg aaggaggtcg cggctcgcgc gcttcatgag 785341 aacagtgaga gacggcacgg tccgtttgtt gctgtcaatt gcggagcgat tccgtctgat 785401 ttgattgaaa gcgaactgtt cggatatgca gagggcgctt ttacgggagc gaaacgaaat 785461 ggctataaag gcgcctttca aaaagcgaat caaggcacat tatttttaga tgaaatcgga 785521 gaaatttccc actcgatgca ggttgcactt ttacgggtgc ttcaggaacg caagataacg 785581 ccaatcggcg ggacgaaaga aattccggtt gatatcagag ttattgccgc cacacattgt 785641 gatttacgcg agcttgccga aaacggaaaa atcagagagg acttgtttta ccgtcttcat 785701 gtctatccaa ttgaactccc tccattacgc gatcgcaccg aggatatccc ggatctcttt 785761 gagtactaca aacagaagaa tcattggcca ggcgatcttc cttctgattt ttgtaatgtg 785821 ctgaagcaat ggaagtggcc ggggaatatc cgcgagctgt ttaatgtgtt tgaacgtctt 785881 tctatcagat ttccggacgg ccggctgaga gatgaatcgc ttcccgcttt actggaagcc 785941 gctggattgc cggccagctc tgcagaaaaa aagccggctg ctgccggcgt gcttactttt 786001 cgtgagcaaa tccaaaagga tatgatgatc aaagcgcttg aatctgcaaa aggaaacgtc 786061 tctcaagccg caaaaatcag cgggatcccc cgaagcactt tctacaaacg cctgaaaaaa 786121 ttcaacttgt ccgctgaatc ataaagcata cttccttcag gaaatggaaa cgttatgtat 786181 tgaaggaggg tgttacgatg aatattcaaa gggcgaaaga aattgtagaa tctcccgaca 786241 tgaagaaagt aacatataac ggcgttccta tttacattca gcacgtaaat gaagaaactg 786301 gaacagcaag aatttatccg cttgacgaac cgcaagagga gcatgaagtg cagctgaaca 786361 gcttaaaaga ggattaaaca aaaatggccc gcttcataag caggccattt tgttatccgc 786421 gcggcgcaaa taaaataaca cagacaccga tgagacaaat gaatgcgccg atccagtcat 786481 acagatcagg tgttttccgg tcaacaagcc atccccacag gaccgcaagc acgatgaata 786541 ctccgccata agcggcgtat acacggccga aagatgggaa ggactgaaac gtcggaagaa 786601 tgccgtatac aatgaggatc agcgccccgg cgattccgta gccagctggc tttgcctctc 786661 tcagccatag ccaaaccaga tatccgccgc caatttcagc aagccctgcc gcgagaaata 786721 aaagaatggt aatcagcatc atgagcactc ctcaatttgc atttatcttt cattatagag 786781 gaggagagct tttaaagctt cggatgattc tcaaattcct tcaaatacgc ttttcgctga 786841 acctctgtaa attggctgat ccaattgttt tgagcctctt cattcaaatg gggaaggata 786901 tagcgttcaa ccgcttcgaa aaacagcgga ttcgtgatga tgttccaggt cgggattcga 786961 acgattttgc cgtctgtttt ctcgatgata atatcctcaa aaaagatccc tttcaaactg 787021 tattgatggc gtcccatata aagccgcttc acctcggaaa acagcacgct gcgctttctc 787081 aagaagattt cgccactagg tccggtcttt atggtgaaaa tgacatttcc acggcttgtg 787141 aacgcaggaa aagccataaa gaatgtgatc aatccataaa tcatcgccag taatccgccg 787201 cccaaataaa gcagggcata tttagattca aacgtgaggg cttcagacac cagccagact 787261 cccacaataa aggcgccccc tgtagcgagg aacagccaag cccttagaaa catcatgctt 787321 tttacttcaa tcatgtgctg cccctaaagc ttcggatgat tctcaaattc cttcaaatac 787381 gcactgcgtt ggatgtctgt aaactgtccg atccaattgc ttttcgcctc ttcattcaga 787441 tgtggaagga tatagcgttc aaccgcttcg aaaaacaacg gattcggaat gatgttccaa 787501 gtgggaatgc gaatggtctt ctgatccacg gtttggatca atatatcttc ttggaagatt 787561 ccttttagac taaatttatg gcggctcatc tcaattttct tgatatcagt aaacgtaaca 787621 gacactttgt cagtgaacac ttctccattt tttcctgtct tgatgcggaa aatggtattt 787681 ccccgcgggg tgaaagccgg aaagaagatg ataaataaat ataaacaaaa caaggtgaac 787741 agaaagccag caggaatggc taataggtaa tatttcgttt gaaacgtaat acccatataa 787801 aagagccaca aacatgctaa tcccataccg gcagatccga caaaagccca tattctcagg 787861 aacattttgc ttttgacttc aatgatttct tggtttttca atgcttttct ccttttgtta 787921 attcaattct tatcattttg aaatgatttg atttacaaca tccttatgag cagggaggat 787981 agaaaattca ttctgggtga tgcctgtgac aagccaagta tggtgggccc ccggcaggac 788041 gaatgccatg tcagccactt caggagtgtt atcttttcca tatgccagac gcataagtgt 788101 atccattttc cctttccgca aagccagatc atttgcaaat cgggtaacgt cctcttggtg 788161 gtcatgtttt tcaaggaact cttttagata tgaagggttg tctgaagcgc cctccaagag 788221 tttttcaaat tcatttgatg tcaatgttac aatcgattct cttttatcct ctgtatctat 788281 tatatgtaaa aactcatctg tcttagcaag taacccttca cttgattcca tttttgtaat 788341 gcgatggact tgttcatcaa aaaggagttc gtgagagtag gtgccgaatt ttgatacatg 788401 gcatgacaca ttctgttcgg caccttgccc gttaaattta gaaagcttca ctgtatagtc 788461 agcgtcgttt aatacatgga taaacggaca gtactcgtcc tttaaccgat attgatggtt 788521 ccgatattcc gctgcatcct tggctaagag tgagcggcac gcggcttcaa ataaggcgcc 788581 gagctgttca tcttctattt ccggaaaata ggcctgcttc aaggccattc cctgttcaaa 788641 aaacccttcg ctgtaaaagc aaaacaagag ttcttctatg ctaattgtaa actgcttcat 788701 tgtttattct cctatccaaa tgaaaatttc cctttaagga aatgggttgc gccgtgtata 788761 agcgaatccg ctgttttctt tgctttttcc attccttttt tcgcgctgtc tatcccttta 788821 tgtatcgatt tattcgccgc atctatgccg tcattcactg atttgacgac tttgccggct 788881 gattccagcc cttttttggc tgtatcaaca acagcatgga tcggttcttt cagctttaag 788941 gctgcttttt cagcaaaacc ggctgtatat ttggcgattt gttctccgac gactccgcca 789001 atgtatgaac ctgctgcccc aagaaggaca gtacccacag gtcctgcaaa gcttccgatt 789061 gcaccgccga tgacagcacc agctgtggca ccgccggcaa caaaaatcgt attattcaca 789121 gcattcccga cggccttggc gttttcacgc ttgagaactt ccggtttatc ctggtatttt 789181 gcataatttt cagcaatttt cacgcctgct ccgaatgttt cggtcgctcc ggtaatcagt 789241 gtggcggtaa tggcatttcc tttcgcgaat ctcaagcccg tttttcccac atccttcaaa 789301 gtggagcgta cgccggcttc attaagaaat ccttttgtgt agcttctgac gctgtttgaa 789361 aaatccaccg tgtcctgagg aaagtatttt gtaaactttt tatgtaccaa atctgaaaat 789421 ggacggtttg tctttttcaa caaatattta ggattcaaaa gcactcttgc cgctttttga 789481 taacgtgagc tgtcaacggc cctggaaata tccaagagca gttttgagtg ctgggctgta 789541 tgcaagccgc ttggttgttt cacaaatttc gtaagcccta atccgtaata ttttccctgc 789601 gtcagcataa gagcggttaa gcttgtcatc gtaccgtatt tgtcgtaggc attgtagagc 789661 tttcgcaaaa tatcatcttg ttccacaaat ttatcgcctg tttttctgat gaaaatctca 789721 ttgtcactca gcttagtgac gagcgccttt cctgagctcc acgcatcgcc cactccagaa 789781 aaacagctgc tgtagcgggg atcgcattgc aaaatcatct gccccagctc cacatgcagg 789841 tccttatatt tgttttccat atcagttaat tcagtgacta catcatttgc aagctgttcg 789901 agcttatccg gatcaactgc aatgtttcct gacacaccgt tcacctcccg agtttatgtc 789961 tttcctctct tgctttacgc tccagttctt ccattctggc aatttcagct tttcgttctt 790021 ctattttgac agcggcagcc ttcagctctt ggcttgtttc aagcagctcc tgttcgaatt 790081 gatcgtaggc ggctttcgtt tcctcgaaat cctggtcaaa cgaatctctt gctttgccct 790141 gccaagcatc tcccaatgca gataaccggg attcaagcag cattttggag cttctgacct 790201 cttctgcggc cgcactatac ttgtttgcca gctcaatgac tttatatgag tccaactttt 790261 gtcccctgcc ttttctaaat tcacgcacaa ttggatgttt tatataaatg attataaata 790321 attcggcatg tatccgaatc gtacaaaaga accttttcat aagaattgga agggcgtata 790381 ttcacttaaa attcacagtt ggtgagactt taagattaca aaaaaggtaa aaaaaccaaa 790441 tctctcagac ataaggcaaa tgagaaattt cccgctctat gggaaaaaac actaaagttg 790501 atcaaatgac ctaagtgcgc caaacgtgtt acgggacgag ctatctcatg gtataaatgg 790561 aattgtaaac gttatcaagg aggtcgtcat atgaagaaaa aatcattctc aatcgtaata 790621 gcgggcggag ggagcacttt cactccaggg atcgtactca tgctcttgga ccatttggag 790681 gagtttccga tcagaaagct gaagctgtat gataatgata aggagagaca ggatcgaatt 790741 gcaggcgcct gtgacgtttt tatcagagaa aaagcgccgg atattgaatt tgcagcgacg 790801 actgacccgg aagaagcttt tacagatgtc gattttgtta tggcgcacat cagagtaggg 790861 aaatacgcga tgcgcgcgct tgatgagcaa attccgttaa agtacggagt tgtcggccag 790921 gagacgtgcg ggccgggcgg gatcgcatac ggtatgcgtt cgatcggcgg tgtgcttgaa 790981 atattagatt acatggaaaa atactcgcct gatgcgtgga tgctcaatta ttccaatccg 791041 gcggcaattg tggctgaagc tacgagacgc cttagaccga attctaaaat tctcaatatc 791101 tgtgatatgc cggttgggat cgaagaccgg atggcgcaaa ttcttggctt atcctcaaga 791161 aaagaaatga aggtccgcta ttacggattg aatcatttcg gctggtggac atcgattcag 791221 gatcaagagg gcaacgattt aatgccgaag ctgaaggaac atgtatccca atacggttat 791281 attccgaaaa cagaggctga agctgtggag gcaagctgga atgacacgtt cgccaaagcg 791341 cgtgacgtgc aggctgcaga tcctgacaca ctgccgaata cgtatttgca atattatttg 791401 ttcccagatg atatggtgaa aaaatcaaat ccgaatcata cgcgggcgaa tgaagtcatg 791461 gaagggcgcg aagcttttat tttcagccaa tgtgacatga tcacacgtga acagtcctcg 791521 gaaaacagcg aaattaaaat cgatgaccac gcatcgtata tcgttgatct tgcccgggcg 791581 attgcctaca acacaggtga aagaatgctg ttgattgttg aaaataacgg tgcaattgcg 791641 aactttgacc cgactgcgat ggttgaggtg ccatgcatcg tcggctcaaa tggacctgaa 791701 ccgattaccg ttggcaccat tccgcaattc cagaaagggc tcatggagca gcaggtatcc 791761 gttgagaagc tgactgttga agcgtgggca gagaaatcgt tccaaaagct gtggcaggcg 791821 ctgatcctgt caaaaacagt gccgaacgcg cgtgtggcaa gactcattct tgaggattta 791881 gtggaggcca acaaagactt ctggcctgag cttgatcaaa gcccaacccg catatcataa 791941 atgaaattcc cccattttcg aatctgtaat tgtatataat agaaagaaaa tggggggatc 792001 tgatatgcag ctcgaagaac tgatcaatca gcactacagc aaattgaatg acaacgattt 792061 tcatatttta aaatatatat tgaatcataa gcacacatgc tatcaccttg gaatcgacgc 792121 gctggccaaa gcttgcagtg tatcgcgttc ctcaatttta cggcttgccc aaaagctcgg 792181 tttcagcggt tacagtgaat ttcgcgtctt tttaaagtgg gaagatcagc cggaagaagg 792241 cgagagtatg agttttgaaa agctgcttga tgatattgaa gcaaatttga agtttttacg 792301 gacaaaggac atgacggaca tgtgccagct gattgatgca gctgaccgca ttttcgtcta 792361 cggttctgga aatgcgcaaa agatatgcgc ccgcgacctg caaagaatgt ttattccgcg 792421 ccatcgctat cttattttga ttgaagacac aaatgaattt aatttgatgc gcgatgattt 792481 taaagtgaac gatctgttta tcatcatttc tctttccgga gaaacaccgg agctgattcc 792541 tcaggcaaga atgctttctg caaagggtat tccctttatt tccattacga atttaaaaaa 792601 caatgtcctc gcccagctga ctccgcataa tctttatgcg acaagcaaac ctgtgacatt 792661 aagcgataga acggaaattg tcgcttttgc accgtttttt ctcgttggcg aagcattgtt 792721 ccgcgcatat gttgattaca aagaggcaga aaaaaatgac aatgagtagc agggggttct 792781 ggtatgatgc aaaaaattca gcgctttgga agcgcgatgt ttgtgcctgt tttattattc 792841 gcgttcgccg gcattatcgt cggtatcagc acgctcttta aaaataaaac cctcatggga 792901 ccgctcgccg atcctgacgg tttttggtat cagtgctggt atatcattga gcagggcggc 792961 tggactgttt ttaaccaaat gccgctctta ttcgccattg gcatcccggt tgctttggcg 793021 aagaaagctc aggcacgcgc ctgtttggaa gcgcttactg tctacctgac attcaactat 793081 tttgtcagcg cgatattgac ggtatgggga ggagcatttg gcgtcgacat gaatcaagag 793141 gtcggcggaa cgagcgggtt aacgatgatt gcgggcataa aaacgctcga taccaacatc 793201 atcggagcca tctttatttc ttcgattgtc gtctttttgc ataatcgcta ttttgataaa 793261 aaactgcccg attttctcgg catctttcaa ggctcaacat atatcgtgat gatttccttc 793321 tttattatga tcccaattgc gttggctgtg tcttatattt ggccgatggt tcaatcggga 793381 atcggctcgc ttcaaagctt cctggttgct tctggggcgg tgggcgtttg gatatacacg 793441 tttttggaac ggattttaat tccgaccggc cttcatcact ttatttacac gccgtttatt 793501 tatggcccgg ctgtagcgga aggcgggatc gtcacgtatt gggcacagca tctcggcgaa 793561 tattcgcaaa gcgccaaacc gctgaaggag ctctttccgc aaggcggatt cgcgcttcac 793621 ggcaactcga aaatcttcgg tattccgggt atcgccctgg ctttttatgt gacagccaaa 793681 aaggaaaaga aaaaactcgt cgcagggctg ctgattcctg tcacactgac agcgattgtc 793741 gccggtatta cagagccgat tgagtttacg ttcttattca tttcaccttt cttatttgcg 793801 gttcacgccg tgcttgccgc cacaatgtcg acagttatgt atatggccgg cgtcgtcgga 793861 aatatgggag gcggactgat tgaggcggta accttgaact ggattccgct ctttggcagc 793921 cacggtatga catatgtgta tcaaattttg atcgggctct cgtttacagc aatttatttt 793981 ttcgtcttca gatttttaat cctcaaattc aatatcgcta caccaggacg ggaaaaggat 794041 gaacagcagg aaacaaagct atattcgaaa aaggaataca gagaacgaaa aaacaaggat 794101 gaaacggcct ccgctgctga aacggctgat gacaccgctt ttctgtatat tgaagcgctg 794161 ggcggaaaag acaacatcac tgaagtcaca aactgcgcca cccgcctcag agtcagtgtc 794221 aaggatgaaa caaaggttga acccgacagc gtattccgcg cgcttggcgc acacggcgtt 794281 gtcaggaacg ggaaggcgtt tcaggtaatt atcggattaa gcgtgccgca gatgcgggag 794341 cgtgtggaaa aaatattgaa tcaataaaga ctgccctcct tttcgggagg gttttcgttt 794401 gccgtcaaaa agaccgccat agtaaagtaa agaaagagac aatcgagtaa aaaggggttt 794461 ggaggctttt acatgcaaaa ggctttgtcg tttttaaaac catattcatt gctggcggga 794521 attgctctga ttcttatgct gacggagctt gcagttgaac tgatgcagcc tttattgatt 794581 gcaaaaatca tcgacgatgg gatattgaag caagatctgc ggcatgtatg gatatggggc 794641 acggtcatga tcgggctgac cgtgttatcc tttgcggcgg ggatgctgaa ttccttttat 794701 gccgcccatg tcagccaaag cttttcctat gatacgagaa aagggctttt tcaaaaaatc 794761 cagtccttct cctattccac atttggacag ttttcgtcct cttcttatat tacaaggctg 794821 acaaacgacg tcacacaggt tcaaaatatg atttttatga gtttgcggtt tatgctgcgg 794881 gctcccttaa tgattgcagg cggcattgtg ctgtcgcttg ccgttaatgt gaaactcggg 794941 ttttttctgc ttgtgaccat tccgatcctg atcttgtttt tgctatgggt attaaggaaa 795001 ggcggggcac tgttccgctc agtgcagaaa aggctggatc aagtgaacac catcatgcag 795061 gaaaatttaa ttgcaatcaa gctgatcaaa gcgctgcttc gcggcagcca cgaagtcaaa 795121 cgatttatca aagccaacac aaggctgatg gaaaaaacgg tttcggcctt tcagcttgtg 795181 gaattcacga tgcctgtact gatgctgctg atgaatctct gcatcctttt gattttgtgg 795241 gcggggtcct acagtattac gagcggaagc actcaggttg gcgatgttgt tgcgataatt 795301 aactacgcaa cacgaattac aggcgcgctt tcgatgtttc cgtttttgat tatgattttc 795361 acccgggcga aggcttcagg ggatagaatc ggtgaggtgc ttgaaacaga aggcgacgag 795421 cgggaggaag gcaccatatc tgatcgtttg tcaggacgga ttgagtttca gcatgtatcc 795481 tttcgctatc ctgaaatgga cagagaagcg ctcaggaatg tctcattttc cgcaaagcca 795541 agagaaacga tcgcgattct cggtgcgacg ggctcgggca agtccacgct ttttcagctc 795601 attccgcggc tttatcagcc ggattcaggc cgcatttaca tagatgaaaa gccggttcaa 795661 gatattccgg ctgaagggct gcgcaggcaa attggatatg taccgcagga agtcctcttg 795721 ttttccggca caatcaaaga aaacatcgct tggggcaaag aaaatgcttc actagatgaa 795781 ataatggatg cggcaaaact tgcgcaaatt catgaaacga ttttaaagct cccaaatgga 795841 tatgacactg ttttggggca aagaggcgtc aacctgtccg gcggccaaaa gcagcggatt 795901 tccattgcgc gggcgctgat tcgaaaaccg gctatccttc tattagatga cagcacaagc 795961 gcgcttgatc tgcaaacgga ggcgaagctg cttgaagcaa tcagcacata ccattgcaca 796021 actttgatca ttacacaaaa aataaccacg gcgatgaaag ctgatcagat tttgctgctt 796081 gaggacggcg aactgattga aaaaggcact cacagtgagc tgctttctga atctcagtta 796141 tacaagcgca tttacgagtc acaattcgga agggagggga gcgagtcatg ctaaaagaca 796201 tccgcaagcc tttccaatat cccaaactgc caattgacaa aaaagaaggc gcgaaaaagc 796261 gggcgaaagc aaaggataca aagggcacac tgagacgaat ctggtcttac ttggctgaaa 796321 gaaaaggact gctcatactt gtcatgctaa tggttgtcat cagcgccata ttcggactcc 796381 ttggtccctt tgtgatcgga aaggccatcg accattttat cgtcgggaaa acggtcagcg 796441 gcttgattcc tgttttgctt cttctgctcg ctatctatat cattcagtcc ctgtcgcttt 796501 ggtttcaaaa ctattggatg attacgatct cgcagggcac ggttttcaga atgagaagcg 796561 aattgttcac ccatctgcat gagctgccga ttccattttt tgataaacag cggcacggcg 796621 agctgatgag ccgggtgacg aatgacatcg aaaatgtcag ttctacctta aacacgtcag 796681 tcattcaaat tttgtcaagt gtgatcacct ttgtcgggac gattgcggtg atgctgtaca 796741 tgagcccgct ccttactttg attacgctga ccattattcc ggtgatggca gcgagcctga 796801 aatggatcac caaccgaacg ggaaagctgt ttaaagaaca gcagaaaaac cttggtgatc 796861 tgaatgggta tattgaggaa tctgtttcag gcgcaaaggt catcaaagca tattcacgtg 796921 agaagcagat tactgctgaa ttcctcgaaa aaaacgctgc actcaagacg tcgggctttt 796981 gggcgcagac gatttccggg tttattccga aggtcatgaa ctctttgaat aacttaagct 797041 ttacaatgat tgcggcaatc ggcggtttgt ttgcgctgaa aggctggatc tcgatcggct 797101 ccatcgttgt ctttgccgag tattcaagac aatttacacg ccctttaaac gatctggcca 797161 accagtttaa tacgatgctg tccgcaatcg ccggcgctga acgggtgttt gacgtgcttg 797221 atgaaaaaga agagcgcgag gatgaaaaga acgccgtgca tcagcccatc caaacaggca 797281 gcattgaatt ccgggatgtg tccttcggtt acgataaagg gcagcagaca ctgaagcatt 797341 tacagtttac cgtgcctgcg gggcagtcca tcgcgtttgt aggaccgacg ggggcgggga 797401 agacaaccgt cactaacctt ctcgcccgtt tttacgagcc taacgatgga aaaattttaa 797461 tcgatggtac agatattaaa acccttacta gagcaagcct aagaaaaaac atggggtttg 797521 ttcttcagga ttctttctta tttcagggaa cgatcagaga aaacattcgc tacggcaggc 797581 ttgatgcttc tgatcaggaa gtcgaagccg ctgcaaaaac agcgaatgcc catagtttta 797641 ttgaaaggct gccaaaaggg tatgacaccg tactgacgca aaacggttcg ggcatcagtc 797701 aagggcagaa gcagttgatt tctatagcga gggcggtgct tgccgatccg gttcttctca 797761 ttttggatga agcgacaagc aacattgata ccgttacaga agtcaacatt caagaagcgc 797821 tcgcccgttt aatggaagga agaacaagcg tcatcattgc ccacaggctg aacaccattc 797881 aaagagcgga ccagattgtg gtgctaaaaa acggtgaaat gattgaaaaa ggcagccatg 797941 acgagctgat tcggcaaaaa ggattttaca gtgacttata tgaaagccaa tttgagaaat 798001 agacctttgt cctgcacaga ggtctttttt tgttacagtt ttatagtact tttatttcat 798061 tttcgtaaaa tgtaacaaaa ttacttgacg taaacaagtt atgtatatat actagcttac 798121 attaagtaag tgataacatt tatcaaggag gataaaatga ataaatcatt tgaaattggc 798181 acattacttt taagagttat tacaggtatt atcttttttg ttcacggttt atcaaagttt 798241 cagggaatgg agggcaccat ccaatttttc ggcagcatag gccttccaag ctttatggcg 798301 tatgtcatcg cagcgattga actgattggc ggagtgcttg tcttcttcgg attggctaca 798361 cgtattgtcg gtgtactgtt cgctcttaca ctgatcggcg ccatcatcac tgttaagctg 798421 aaagcgccat tcatgggcaa tgcagaattt gattaccttc tgcttttgac atccattcac 798481 ctggcgctta ctggaagtcg attcctggcg ctggacccat ttgtgtttaa aggaaaaaag 798541 aacggaaacg tttcagcata agaaaagagg catgcagcat gaccagcatt catgaggata 798601 cacacattgg ctatgccaaa ctcacaattc gcagtctgga gcgttcgctt cagttctact 798661 gtaacgtcat cggttttcaa gtcttaaaaa agacggaccg ccaagcggaa ttaacggctg 798721 acgggaaacg cgtactgctt attcttgaag aaaatccgag cgctgtcgtc ttgcctgaac 798781 ggtctgtgac aggcctttat cactttgcga ttcttcttcc ggacaggaaa gaacttggga 798841 tcgcgctcgc ccgcctgatt gaacacggca ttgctatcgg acatggagac catgctgtca 798901 gcgaagcgct ctacctgtct gatcctgacg gaaacggcat tgaaatgtac gctgaccgcc 798961 cccgcagcac gtggcagcgt gatcgggaag gaaactacgt catgacgaca accgctgttg 799021 acattgaggg ccttctggaa gaggcaggag atgagcggaa aacatcgctt ccgaacgata 799081 caatcatcgg acacattcat ctgcatgtca gtgatttgaa agaagcaaag gcgttttata 799141 cagatgtact gggctttgac attgtcggaa actatgcggg catgtccgcc ctcttcgttt 799201 cagccggggg gtaccaccat catatcggct taaacatttg ggcgggaaga aatgcgccgc 799261 ctaaaccgac aaatgccagc ggactagatt attatactgt tgtcctgccc caccaagagg 799321 agctggattt ggtggcaaac cgagtcaaac atgccgggta ttcgattgaa gagacggaaa 799381 acagctttcg tgtgaaagac cctgtttccg gcgcctatat tacatttgtg atttaactgc 799441 aatccccttg ccgaaataac ggcaggggga ttttttattt ttgtccgcct tgttatgatg 799501 agagaaccaa cttgttagga ggcgtttaca tggaactcaa ccaccttgtg acgggcaaaa 799561 tagcattaaa tcaatatgtg catcgcttag agcaaaagga tgtttcattt tacgtccact 799621 actggggagc gatgacgaac cactataaca cactgcttca taagcattcc ttttatgaaa 799681 tttgttacgt ggtaagaggt gaaggatatt accttgaagg cgatcgtaca tatccgcttc 799741 gtgaacagac gatttttttg tcaaagccgg agcatttgca ccaaatcaaa agtgaaacag 799801 ggctgttcct tttttacgtc gctttcgagc tgagcgagga tcagtcaagc gccgaatgga 799861 tcaaagtgat ggaagaagtg aaacaaagcc cctttatcac aatgcaattg aaagatggcg 799921 aaccgccggg cctgctttgg aaaacgttaa tgctgcaagc agcgcaacct gtcaatgctt 799981 ttgacaaaga gatcctatct catttgtcgc atgcattgat cctgtcatta atccaaacct 800041 ttctcccgta cgcccaacgc ccgaaacaaa agcagcccat tcacacatct tctgctttgc 800101 tgacagaggt gaaactgcac ataaaagaca atctgtcaca gccgttaaag ctgacggatg 800161 tcgctagcca ctttcatatc tcagggaggc atttatcacg tttatttgca gcagaactgg 800221 gcgtcagcta ctcagaattt gtccaaaatg aaaaaataaa caaagctgcc gaactgctga 800281 aatcaacgaa tttgtcgatt aaagaaatag cggaagaaat cggtttctca gtacattatt 800341 tcactcgcgt cttttccgct aaaatcggca gctctccagg gcttttccgc tccctttata 800401 aagactcaaa aatgaccgca tttcaaatca ataaaccttt tcaaaaaatc gaacaggcca 800461 agccgcacga ataagatgtc ctgaaatgac aaaacaatgt cttcatatga taaagacgcg 800521 agaaatctcg ttgtcttata atctttttag aaagcggtta caacaagggg tattgctgaa 800581 ggagggatgc attggcttat gcttggtgtc gggtgctctg ccattcttga aagaagggga 800641 agaaagccgt gagtacaaaa aagaaagagg ctgtaatagg aaaagaaagc ttagctcata 800701 aagggctttt acgaacgatt acattggtat ctacattcgg cggcctgttg ttcggttatg 800761 atacgggtgt cattaatggg gcacttcctt ttatggcaac tgcaggtcag ctgaatctta 800821 cacctgttac agaaggactg gttgcgagtt ccctgcttct cggggcagcc ttcggggcga 800881 tgtttggagg acgtctgtcc gatcggcacg gccgccgaaa aacgatcctt tatttagcct 800941 tactcttcat cgcagccaca cttggctgta ccttttcacc aaacgcgtcc gtgatgattg 801001 cctttcgttt tctgcttgga ctggcggttg gctgcgcttc tgtaacggtt ccaacctttt 801061 tagcggaaat ttcgccggca gaacgcaggg gacgaatcgt gacacaaaat gaactgatga 801121 tcgtaattgg ccagcttctg gcatacacct ttaacgccat tattggcagc acaatggggg 801181 agagcgcaaa tgtatggcgg tatatgctgg tcatcgcgac acttccggct gttgtgttat 801241 ggttcggaat gctcatcgtg cctgaaagcc cgcgctggct ggcagctaaa ggcagaatgg 801301 gtgacgccct gcgggtgctt cggcaaatcc gtgaagacag tcaggcacag caggaaataa 801361 aagaaatcaa acatgcgatt gagggcacag caaaaaaggc cggctttcat gattttcaag 801421 agccgtggat aaggcgcatt ctattcattg ggattggaat cgccatcgta cagcaaatta 801481 ccggtgtcaa ttcgattatg tactatggga cagaaattct gagagaagcc ggttttcaaa 801541 cagaagctgc attaatcggc aatattgcaa acggtgttat ttcagttatt gcggtcattt 801601 ttgggatatg gcttctcggc aaagtccgtc gccggcccat gctgatcatc ggacagattg 801661 gcacgatgac agcccttctg ctgatcggga ttttatccat tgtccttgaa ggaacacccg 801721 ccctgccgta tgttgtgctg agtttgacca ttttgtttct tgcgtttcag cagactgcca 801781 tttctacggt gacgtggctg atgctctcgg aaatctttcc tatgcatgtg cgggggcttg 801841 gcatggggat cagcaccttc tgcttgtgga cagctaactt tctcattgga ttcacctttc 801901 ccattttgct caatcatatt gggatgtcgg cgacattttt tatctttgtc gctatgaata 801961 tcctagcgat tctatttgtg aaaaaatatg tgcctgagac aaaagggcgg tcacttgaac 802021 agcttgagca ttcctttcgc cagtatggcc gccgcgctga tcaggaaatc caaaatcaaa 802081 caactcactt atcgtaacct gagataccag gaggaatcta tcaatgaaac tatcttatgt 802141 aacagacagc ctagggcatt tgccttttga agacatgctc aattttgccg caaagcttgg 802201 gatcgataca cttgaaatga caaccggggg ctggtcgccg gcacctcact tgaatcttga 802261 tgaattgctg caaagcagcg aaaaaagaaa agaattttca caagcgctgg aaaagcggaa 802321 catgacactt tgcgcattaa actgctcggg gaacccttta gatccgggtg aattgggcaa 802381 atcgcacaga gacataactg acaaaacgat ggagctggct ggattattag gcgtcaaaaa 802441 agtgatcatg atgagcggtt tgccagccgg cggcccggac gacaaagtgc cgaactggat 802501 cacatacaca gtaagctggc ctcccgtttt aaaagatatc ctcaactatc aatgggaaga 802561 cgttgcgatc ccatattgga agaagcttgt caaaaaagcg gaggcctgcg gcgtggggaa 802621 aatagcgctt gagaacttca gctctcaatt agtctataat cctgagactc tctttcggct 802681 cagaaatgca gtcggcccga tggtcggttt gaatcttgac ccgagccatt tgttatggat 802741 gggcgcagac ccgatcatcg cagcaaggga gctcggctca gccattcacc atgtccatgg 802801 gaaagatgtc agaattgaaa gatatttatc ggcggtcaac ggacttttag aaacaaaaga 802861 agtgacagat cctgcaaacc gggcgtggaa ttacgtagct gtcggctgtg gacaggattt 802921 acagtggtgg aaggaatttt tttcagttgt aaaaatgatg ggatatgaag gtgaggtttc 802981 tttagaaatg gaggatctga cgatgtcacc tgaagcgggc atccgtactt ctgtagaagc 803041 tttaaaacaa accatcagcc aataggaggt tttcatgatg ctaaatggag aaagaatcat 803101 ctctaagccg cttcgctggg caatggtagg cggcgggcgg ctcagccagg ttggatataa 803161 acatcgtatt ggagcgctga gagacaatac tgcttttcaa ttaactgctg gcgcttttga 803221 tatcgatgcc gaaagaggaa aagatttcgg ggtgaacctt ggagtggatg cggaacgctg 803281 ttatcccaac tatcaaacca tgtttgccga ggaagcgaaa agacaggatg gcatagaggt 803341 agtatcgatt gccactccga acggcactca ttatgagatt tgtaaggcgg cgcttgaagc 803401 aggagtgcat gtcatctgtg aaaaaccgct gttcttcact tcagcagagg ggcaggaaat 803461 caaagcgctc gcagagaaaa aagggaaaat tgtcggcgtg acgtacggtt tttcaggcaa 803521 tcaaatgctt cttcaaatgc gtgcgatgat tgaacaagga atgatcggcg atattcgcgt 803581 ggttgacttg cagtacacac acggtttttg tgcaacagat gaaggtgaaa agataagcgc 803641 tgcacagaaa tggcgtgtcg accctgcgat cgccgggcca agctttgtgc tgggcgattt 803701 atctacccac acgtattata tgtcacagct tattatgcca aagatgaaaa ttaaggagct 803761 gctgtgtgac cgacagagct tcgtcggcag ccgcgcaccg ctagaggata atgcccatgt 803821 gctgatgcat tatgaaaatg gagcggtcgg aacgatgtgg acatcgtcaa tcaatgccgg 803881 atgtatggat ggccatagaa tccggattgt cggctcaaag gcaagcattg agtggtggga 803941 cagcaagcca aatgaactga cgtatgaagt gcagggagag ccgggccaga cactcgttcg 804001 cggcatgccg tatttagatg atgtttgcaa cgccgatgaa cgactgggcg ccttacacag 804061 cgaagggctg tccgaagcat gggccaatat ttatcttaaa tttgccattg cgatagacgc 804121 caaaaaccgt gaagatgaag aaatcttgaa caacttggtt tatcctgaca ttgatgcagg 804181 gatcgagggc attcgctgga ttgagaactg cgtgcgctcg gcaaaccaag ggtcagtttg 804241 ggttgaattt aaataaatga gggaatgcgc cgcatatgac ataaagttca tatgcggttt 804301 ttattttcca gaaactcctg tcaaaaatgc cctgaggcag gtatgataag aagggaattg 804361 ggtatcggga gtgatgagcg tgaaagctct tttttttacg agaatgttca ccttgatggt 804421 gagctgttta atgtatctgt ccattgtgaa agaggataac tggtttggat atgtatttat 804481 agcagcaggt gctgccatgt atgcagccaa tcatgttttg ctgacaaaag agacaaatgc 804541 catctggttc tgcctgattg atattgcaat cggcttttcg ttcggattta tctttcccgg 804601 cacaggtttg ttcattatta tgctttgtcc ggttgcggtc gccttttttc tgcgggggtt 804661 tcctaaaaga acagcatggt ctgtcttatg tctttcctct attttatttt tgaccgtcct 804721 catccgtaca tatgcgatgt tcggcaatga atttgtcatt gatcatttga ctagcatgac 804781 attcgttgtc ttctgcggtg tcgtgggcaa attaatccgc aagctgttgg atgcgcagga 804841 tacggcaaaa cagcagtttc aggaactgac ggagtcccat ctggcgctgt ctgctgcaca 804901 tcaggagctc catttatatg cgaagcaggt tgaagagctg actgccattt acgagcggaa 804961 cagaatggcg cgtgaaatcc atgatacagt ggggcataaa atgacggccc ttctcgtcca 805021 gctgcagctt ttgcgtgaat ggcaaaaaag agacagccaa aaagcggatg agacagtagg 805081 tgtctgtgaa acacttgccc gtgaagcgct tgatgatgtc cgcttatcag tacgcactct 805141 gcaaactgaa aacgatcctt cgctaatcga atcgctgaaa cagctgacag aggacttttg 805201 caaaaatgca ggagtcacaa cagaatttgc ggtcagcggt gatcctgcaa tcatcccgct 805261 gtctctccat ccgaccctga tcagaacggt gcaggaagca ctgaccaatg ccaaacggca 805321 cggcggcgcc gcagcctgtt cgatacagct tgcctgcaca acggacagca tcagccttgt 805381 cattaaggat gacggcaaag gcaatcctga ggcagcactt ggttttggtc tcttgaatat 805441 gaaaaagcgg gcagcggagc atggcggaat gatccgcttt gaaagcgaac gggatcaagg 805501 atttactgta aatgcagaat tttcacttgc caataaaaaa tggagcttcg ggcccgtgca 805561 gcaaaaggag agtttatcat gattaagatc atcattaccg acgatcagga tatcgtcaga 805621 gaagggctgg catccctgct ccagctccga gaagagctcg atgtgatcgc aacggcgcga 805681 aacggacagg aagccttcga aaaggcgaaa gagctggagc cggatatcgt gttaatggac 805741 atccgcatgc cggtttccaa cggggtggag ggaacaaaat taatcacaag ctcgctgcca 805801 agcgtaaagg ttttgatgct gacaaccttt aaggattcag cgctgattgc tgaagcgctt 805861 gaagagggag caagcgggta tctgctgaag gatatgtctg cagatacgat tgtaaaagca 805921 gtgatgactg ttcattctgg cggaatggtg cttccgccgg aattgactgc ccaaatgctg 805981 aatgaatgga agcgtgaaaa acagctgaaa ggaataaatg agatagaaaa acctaacgag 806041 ctgctcgacc tgaccgagcg cgaaatcgaa gttctggctg agctgggata cgggctgaat 806101 aacaaagaaa ttgccgaaaa gctttacatt acagaaggca cagtcaaaaa ccacgtttca 806161 aatattatca gcaagctggc tgtcagggac agaacccaag ccgccattta ctcggtcaga 806221 tatggtgtat ctgtcttttg acatatgacg ttttgcatat acgcttctct gaaaaggcct 806281 tttacaggcc tttttttcat gccctatgtt ctatctgccg ctacatgccg cacgcctttc 806341 tttcttctac aatggcaatg gatcaaaaaa aggagtgaga cgacgtgctg caagcagaaa 806401 acatcaaaaa ggcatacgga aaaaaaacaa tcgtgaaagg catttctttt tccctcaaaa 806461 agggggagtc gttcggtctg ctcgggccta acggtgcggg gaaatccaca accatctcga 806521 tgatttccgg ccttgtgccg catgacagcg ggaacatcac ggtgggcggc tatgttatcg 806581 gaaaagaaac ggccaaagcg aaacaaaaaa tcggcattgt tccgcaggaa attgcattat 806641 atccgacgct gacggctcat gagaatctta tgttttgggg gaaaatgtac ggacttacgc 806701 acggtgaggc caaaaaaaga gcggctgagg tccttgaata tgtcggtctg actgagcggg 806761 ctaaagataa gattgaaaca ttttccgggg ggatgaaacg aagaatcaac atcggtgcgg 806821 ctttaatgca taagcccgag ctgctgatta tggatgaacc gactgtcggt attgaccctc 806881 aatcgagaaa tcacatttta gaaacggtca aacagctcaa cgaaacgggc atgacggtga 806941 tctatacgag tcattacatg gaagaagttg agtttttatg cgaccggatc gggataattg 807001 atcaggggga aatgattgcg attggcacaa aaactgattt gtgcagccgc cttgggggcg 807061 ataccatcat tcagctcacg gtcagcggga tcaatgaagc gtttcttgtg gcgatccgat 807121 ctctggccca tgtgaatgat gtaacagtac atgaattaga gctcaaaatt gacatttctg 807181 cggctcatca tgagaaagtc gtcacaagcc tgcttgctga agccactgct catcatataa 807241 acctgctgtc tcttcaggtg caggaaccga atctggagcg cctgtttctg aatctgaccg 807301 gccgcacgtt gcgggattga ggagggacgg caatgaaaaa aagcatatgg atcgcatgga 807361 aagatgtgaa aatcagaatc acggacagaa aagggtttat gatgcttatc ctaatgccgc 807421 tcatcctaac ctgtatttta ggcgcagcgc tcggatcagt tgttgacgga ggcagccgga 807481 ttgatgatat caaagtcggc tacattcaat cagaccagtc agatacagca aacatgttta 807541 caaaagatgt tctcaaaaaa atgaagtcga taaaggtcac aaaagtcggc agcaaagaca 807601 agatgaaaaa actgattgat gaaaagaaaa tcgatgtagg catcgttatc ccgaaccatt 807661 gggaagccgg caaaacctca gctgttgtta atgccgctcc tgatcaaaca ttgaaaagtt 807721 ccatcattga aacagctgca agctcattta tagagcaata taaagcggta aaggaagccg 807781 cgtcaggctc aatggactac atcagtaaaa cggaagctgt aaagcaagga aaacttgacc 807841 ctgcacagtt tgcagaaaag ctggcaaaga cgctagaaaa agaaacaggt gacaagctta 807901 ctattgcgga aaaatctgtc ggcagcaaag ccgttaccag ttttcaatac tattcggcgg 807961 caatgctttg catgtttatg ctgtttcata tcacagtcgg ggcgaaatca tttttacagg 808021 aaaaggatac ggagacgctt gccagaatgc tgatgacgcc tgcgcaaaaa tccgtcattc 808081 tcttcggaaa atggcttggg acgtatctgt ttgccatcat acaatttttc atatttctga 808141 tcgtcacaat caacgtattt ggtgtggact ggggcggtaa tctgctgtta gtgagtgtac 808201 tcgggctttc ttacgccgca gctgtatctg gtatttcaat gctgcttgcg tcgtgcatca 808261 gcgatatgaa aactgcagat gcgataggcg gcttcggcat tcaattgctt gcggttctcg 808321 gcgggtccat gctgccgctg taccaatttc cggacgtctt gcagtctgta tccaaagcgg 808381 tgccaaatcg ctgggcgctt gacggctttc tttctttaat ggaaggggga ggctgggctg 808441 accttcaaaa gcctgtgctt ctttttgcgg cgatcggctt ttgttcactt gtaattggta 808501 tcagacggct tcatacaaga taaggaggta caaaaggtga aaaaaattct agccatttgc 808561 ggcattgagc tttctctcat ttttaagaag ccacagaact atttgatcat gtttgctgcc 808621 ccgcttttgc ttacctttgt atttgggagt atgctcagcg gcaatgatga taaggtgcgg 808681 cttgcaatcg ttgatcagga cgatacgatt ctctcacagc attatattcg gcagctgaag 808741 gcacacgatg atatgtatgt attcgaaaac atgtctgaaa gcaaagcgtc agaaaagctg 808801 aaacaaaaga aaattgccgg gatcatcgtc atttcccgct cgttccagac acagctggaa 808861 aaaggcaaac atcctgagct gattttccgt cacggccctg agctgtcgga agcgccgatg 808921 gtcaaacaat atgcagaaag cgcattggca acgctcaata ttcaggtgac cgcggcaaaa 808981 acggcatctc agacagcggg agagaactgg aaggcggcgt ataaaacggt tttcgccaaa 809041 aaacatgaag atatagttcc ggctgtaaca cgacagacgc tcagtgataa aaaagagggt 809101 gcggaagcaa gtgacacagc ctccagagca gcagggtttt ccatcctgtt tgtcatgctg 809161 accatgatgg gagcggctgg aaccatttta gaagcaagaa aaaacggcgt atggtccaga 809221 ttgcttacag cctctgtcag ccgagccgaa atcggtgctg ggtatgtgct gtccttcttt 809281 gtcattggct ggattcaatt tggaatattg cttctttcca cccattggct gtttggcatc 809341 aactggggga atccggctgc agttattgta ttagtgtcac tttttctatt gaccgttgtc 809401 ggcattggat tgatgattgc ggccaacgtc agaacgccag aacagcagct tgcgttcggc 809461 aacttgtttg tcatcgcaac atgtatggtg agcgggatgt attggccgat cgacattgaa 809521 ccgaaattta tgcaatccat cgctgaattt cttccgcaaa agtgggcgat gagcgggttg 809581 acagagatta tcgctaacgg tgcccgcgtc acagatattc tcggaatctg cggcattttg 809641 cttgcatttg ctgcgatcac tttcgcagcg gggctgaaag cgctccgagc ctaaaaaaca 809701 tctgccgttt aggcagatgt ttttttgcat gtgggtacat tcgtatgggt gcagcctgaa 809761 ctgcggttaa tccttatcta tcatagctaa aattgattcc agccaagaaa cgtaattttt 809821 ctcccgctcc agcgctttcg ttagcacaag atagtggccg aagtccggtg aagaaaatga 809881 catcggctct gctgaagcca taagcttttc atagcttccc tgtaagtcag aaagcttggc 809941 ctggcgtttt tgcagctggt ctttgaacaa atcagaagcc tcctggcgcg atagacaaga 810001 aatgaaataa gccttcagca taaattcatc cttcaccgtc tcgggtatcg gctggtggcg 810061 gatcagccag tcatgcagct cctgctttcc gctgtctgtc agggtgtaca tctttttctc 810121 cagctttgtg ccctgaatcg ttgtccggaa cgtgataaat ccttcatccg tcagcttttt 810181 gagctcaggg taaatctggc tgtgcttggc gctccaaaac tggccgagct cctctttaaa 810241 ataactcgta atatcgtatc cactcaattc gccttttcgc aaaagcccta atatggcgta 810301 ttttaatact ctcatgctat cctccgtgtc tggctgtttc gcaaaacaga tgagccggtg 810361 ctcaactgtg attctaactg cctattcccc ttattataga aaagggagga agggaacaca 810421 accgggctct ttggaaatga agataaaagg tttgtcagaa ggtatccgat ttatctccgt 810481 caatataaaa gagatttaaa tttaattttc agaaaaaata gtaacgatat tgatttttta 810541 tatataatag gaaattggtg gtatgaaaat tttttggggg aataaacgtg aaaaaagtac 810601 ttatggcatt cattatttgt ttatcgctga ttctatctgt tttagccgct ccgccgtctg 810661 gcgcaaaagc tgagtcagta cataatcctg tcgttcttgt tcatggaata agtggtgcat 810721 catacaactt tttcgctatt aaaaactact taatttctca aggctggcaa agcaacaaac 810781 tgtacgcaat tgatttttat gataaaacag gaaacaacct aaataacggc ccgcagcttg 810841 cttcatatgt tgaccgtgtt ttaaaagaga ctggggcaaa aaaagtagat attgtggctc 810901 atagtatggg aggcgccaat acgctgtact atattaaata tttaggcggg ggcaataaga 810961 ttcaaaatgt cgtaacgctt ggaggggcta atggtttagt gtcatcaacc gcgctgccgg 811021 gcacagaccc taatcaaaag atcctctata catctattta cagtctcaat gatcaaattg 811081 tcatcaatag cttgtctcgg ttacaaggag cgcgaaacat ccagctttat ggcatcggtc 811141 atattggctt gctttctaat agccaagtga acggctatat caaagaaggg ctgaatggcg 811201 gaggcctcaa tacaaattaa tatcttcaaa aaacaacctg ctgtctccgt tacagtgggt 811261 tttttcgtct gagaaagcca tagggtctta tgaccttagt ctatcatgca tacgtcaatt 811321 tatgacatca ggcacttttt caaatagagc ggacatgtta aggtacaacc atcgatttct 811381 atcaatttga aataaaagga gcgctgttat gcaaattaaa gaaattttta tgatccgctg 811441 catttcgtgc ttaagtgtcg tcttgctcca tatcatttca atggtcctga tgcttcaggc 811501 agaagctctt gcagatattt ctcacactgt tgattctttc cgcacactcc tgatgttcag 811561 cacgcccgct tttattttca tctctgaatt tttactggcc cgttcttatc ctgatggggt 811621 gcctgacggt tttttaaaga agcggggaaa agtgattttt gttccttttt tatttatcgc 811681 agccatcgat gcgctgctga tgaccagtgc gatgggggga gaggtaacct ttctcgcgtt 811741 tgtgcaaaaa tatctggcga acgtattctt aggaaacttt atcggatact tcattctcgt 811801 catctttcaa ttttacatgc tgcatatgat gtttcatgag tatttgaaaa aagcatcgcc 811861 gaaatgggtg ctgtctatct catttgtggt gacagccgct tatttaggct atttctccgc 811921 agccagcccg gctcctgctt ctgaagaggg aggggcattt ccgttcttct gggttccgtt 811981 cgcaggctgg cttttctact tttgtctagc ctactattgc ggaaaagaat acaagcgttt 812041 tttagcgctg ctgaaccaat accgctgggt ggtgtacggc gccgcaattg cttctggggc 812101 gctggttgtc actgtttctt atgtcggtga aatcggcatg atcagctcga agcggcctga 812161 tatcatgctg tattcaacaa gcatgatttt cctgtgtttt catttgtttt ccaaaatgaa 812221 gcatgtgccg aaaatcatga tgtttatcag caactattcc ttttcgattt atctgcttca 812281 tgcctatttt atgattatag gctacgtgtt gcttttgaat atgcccgaaa ttcctgccgt 812341 accggctgtt ctcctgttgt ttgccgtgtg cacagccggc ccgattatga cctcatgggc 812401 gctgaataag ttcaaatacg ggtatttatt tgtggggaaa atttatcagc caaaacagaa 812461 gaaggtaaca gtcgaagtgc gtgatcacgc agggtgaaaa acaagcggca ggagggctcc 812521 tgccgcgttt ctttacttct catccgcttg cagaactgtt tttaaatata gttttgcaga 812581 ctcagcaagt ccagatacat cagccttttc ttcatcgaaa tacagggcgt tttgaatgat 812641 gccgtcattc atattgagga aaaacttggc gatagtcgca agaggctgaa ccggctgaaa 812701 ctctccctga tcgatccctt tttgcaatag ccttgaaaac ctttccacaa aaagatcata 812761 ccttttctcc aaatactgcc gccgttcttc attgcgccaa gctgtcacta aatattcaaa 812821 ttgcaccggc gccagcgtat ctgctacatc tcgcaggccc tcagtcagtt catccaaata 812881 gctggaaatg gaggcccaaa cactttggtg ttcagctgat ttatcaagct ttcggagtcc 812941 ttcatccagc cctgtttcaa taatgcggcg aaacatctcc tcagtgcttg aaaaataaag 813001 atagacaccg ccccggctga aacctgactc ttctacaaca tccttcatcg tcgttaattc 813061 gaatcctttt cgtttaaaaa ccgttttggc agcctctaaa atctctgcct gccgtttatc 813121 cttgtgctcc tttgttactt ttggtgacaa gatatcgcct gctttctgca attttcttac 813181 ctataagtgt aatcaaccca atcatgatca gcaagcagcc acagacaaga aaagcaagtg 813241 atacaccgat ccattccgcc agcacgcccc cgcccgccat gccgaggata gaggcgaggg 813301 ttgtcgcact ctgaatagcg ccgaacaccc taccgctgta atcgacaggc actgttgttt 813361 gcacgagaat ctgaaatgga atatggacga ggccgaaagc cgcccccatg atgaaaaaag 813421 caaatataaa gagagtgatg ccggcaattc ccataccgct taggaatggc gcacctccag 813481 ttgctagtcc aagaagaagg gttccagctg agaaataaag caaataagaa gtgattcgcc 813541 gtctgccggt aatggccgct gtaaggagca tcccggctcc gcttacggcc atgcaccagc 813601 ctgccagctc gggcggagct cctgaaaagg agcggataag aataatcgct tgggaatcac 813661 caatctgcaa aacaaagaga acgacacaag ctgttagtaa gcctgttaat agaagcggca 813721 tccgtttcaa aaactgaagg ccttccttga tagaagtaag tgctgctgtt ttttcttgag 813781 gtgtattggc tttttgtaaa aaagcatctc tgggaaggaa aaacaaaatg acagcggaaa 813841 gaaagaaggc gccggcgttt atataaaaaa cagagtgtat cgagaaagca gcgatcagcg 813901 tgccgccaag ggcagggccg aagatttttg agctgttatc aatgatgctg ctgacggaaa 813961 cggcctgctg aatgtgtgct tccggagcca attccttaag ctttccgttt ttagcaggta 814021 aaaaaagtga agaaaaacag ctctgaacgg atagcaatac gtaaagctgc caaagctcac 814081 tgacataaac gcagctgata acagtgaggg cacggccgat ttcagataga aacatgatcg 814141 tttttctgtc aaaacggtcg gcaagcagac ccgatacagg tccgagtaca atgacaggca 814201 aagcaaacga catcattaaa agcgacatat ctaatggaga agcatgaagc tgaaaagcgg 814261 ctaatgttag cacggccaaa atgtgaagcc agtctccaag tgaagaaatg gtttgcgagg 814321 ctaacagtgt catcagtcct ttttgattgc gaaacaacgg tttttccatg attcatcctc 814381 ctgattatta aaatgacact agtgtcgttt ttaattgtat gggaaaaaga cacaatatac 814441 aatctttttc ttgtaaaata aaggagaaga ttgaatagaa gggagaacat tcatgacatc 814501 agtcaatcta agctacccaa taggagaata caagccgagg gaatccatat cgaaggagca 814561 aaaagataaa tggattcaag tacttgaaga agtgccggca aaattgaagc aagctgtaga 814621 ggtcatgacg gacagccagc ttgacacacc gtaccgggac ggtggatgga ccgttcggca 814681 agttgttcat catctggctg acagtcatat gaacagctat attcgtttta aattgagctt 814741 gacggaagag acaccggcta tccgtccgta tgatgaaaaa gcatggtcgg agctaaaaga 814801 ctcgaaaacg gcagatccga gcggctcact cgcgcttttg caggagcttc acggaagatg 814861 gacggctctg ctccgcaccc tgacggatca gcaatttaag cgcggatttt atcaccctga 814921 tacaaaggag atcattaccc tggagaacgc gctcggcctg tatgtctggc actcacatca 814981 ccatatcgct catattacgg agctttccag acggatgggg tggtcttaac gcttttgccg 815041 gcggaaagcc ggaatactga tagcagcaat caccagaagt gagaccacag cagccgctgc 815101 atataaatga tcatagccgc tggcgacact cgcatgaatg gcgtcgctta tcgcggtttt 815161 gacttcagga acgggaatgc gttcgatttg ttcttgtaaa gaagaaactt cagaactgtc 815221 gatctccgga atcatctgca tcgccttttc tgaatatccg ctgtccgata agcggctgtt 815281 gatctcatca cctatttggt caaacccggc tgtgataaaa cctgcataaa gagtaggcgc 815341 caaggtcagt ccaatttgcc ttactaatga aagcgtgcca agagctgtac ccttatttgt 815401 ttttgccgct tctgatacaa ggacgttcag cggagcgcct aacagaaagc caaaaccgat 815461 cccagctgcc acacttgcga tcacaaactc ccatttttcc gtgacccaga gcggaaataa 815521 agcaaacccc gcacatgaga tgattcccga aagaataacg gtttttacag gacctttttt 815581 gtcggtaagt gctccgccaa gccaagcgcc gattccggaa gccaacgcaa gcggtgtcat 815641 ccaatagcct gcttttgcgg cagggacacc caaatactgt tcgacatatg acgggataaa 815701 aatgactgcc gccaagagcc ccccggataa caaaccgatg ataagcgtgc gctgaaacat 815761 atggtttcgc agcagagaat acgccaaaat gggatcgcct cctcgcattt caactctctt 815821 ttcatacgag ataagcgctg caaaacagag tatgccaaaa ataatacatc cataaacctc 815881 cggattcccc aagctgtgta agagatttgc cccgtcaaga ttggtcatgc cgtacatcac 815941 agctaaaatc gacagggaca aaaggaagat tccggccgca tcgaggcgct tagcctcagg 816001 tgcttttgtt tccgcgataa aacatgcgcc gaaaacaacc aatagcacgg caatcggcaa 816061 attaatcaaa aatagccaat gccaagaccc ggtccaatca agcagaaagc ttccgatatt 816121 tggcccgagc acagcggcca tcccgttcat tgcgccaagc agcccaagcg ccttcccctg 816181 tttttccttt ggaagggtcg cgagaatgtg agagctgccg atgatgaaaa tcccgccgcc 816241 tccaagcgcc tgaatcagcc gcgatatcag aaagagcggg aagctttggc tcaaagcaac 816301 aagcaaagaa ccaagtccga acaggcaaac ctcaatgaga aagagttttt ttctgccgta 816361 gcggtcggaa agttttccga cgattggcac actgacgcta agaccgagcg tataaagggt 816421 aatgccccat gatccccagg aaggggaaac ggaaaacgac tcgtttatcg ttgttaaagc 816481 agccgaaata attccgttat ctaaagcagc cataaacacg ccaatcgtaa acaggctgat 816541 tgcccacttt tggcttttct gctctgttaa tgcttcagac attttcgtca actcctttta 816601 gttcacttga aatatattat tcattttaaa tgaactaaat gtcaaataaa aaaagcctgc 816661 tcccgcagtt tgcggatgac agacttactg atttattctt ttttcgcatt ctctaatgct 816721 cttgaaagga tagacagccc ttcgtaaaca gcctgctttt cttcagggga cagcagctct 816781 aatgaacgct tcaatttcag gtggcccttt tcatacaaac cccggaaaat ctttttcgca 816841 ttctctgtca actgaacaac tacagagcgg cggtcctctt cagaatgtga gcgtttgaca 816901 aatcctgatt tttcaagccg gtcaagcagc ccagttgtat tggacaggga agcccccatt 816961 ttttcagcaa tgtcgctcac tttcaatgtt ccatggttgt ttaatagcat cagcaccttc 817021 atttgcggca tgctcatatc cagtttcatc cactcggaca catcaccgag cccggcggac 817081 gttaagactt tcatatagag cacccatatt tcccgttcct ccgatgaaag aatgttttcg 817141 tttaagactg ttgtatcgtg taaattatat tccatttcat cacttcctca tcattcactc 817201 ctcttaccat attactcgat tttcactcct gaaagaaagt gagcagaaac cgcatgcggg 817261 actttgtccg aaaaataacg gtagtgtata atgagttgga gattattggg ggagaggatc 817321 gaactagaat atgattggag agaccattgc tgattaaaaa gaatgcttta tcaatattaa 817381 aaatcgtttt tcctattgct gttttgctat ttgttattta tcaatcgaaa aaagaactga 817441 caaatctgtc attcaaacgt acgctcatgg tcatcaacgg actggaacga acggatttat 817501 tcatgcttgt gttgatcggc ttgctggctg ttgcggctat gtcgctgtat gattacgtcc 817561 tgaagtactc actgcgccta tcgatcacaa acggaaaagt tttcagggtt tcctggatcg 817621 ccaattcatt taataatgtg ttgggattcg gcggtttagc cggagtcggg ttaagaatga 817681 tgttctataa ggagcatacg aaagaccata aggcactcgt gaaaggaatc gcctggctca 817741 catcatctat gctgctcgga ttatctgttt tcagcatttt cgttgctgcg agagtgctgc 817801 cagttgatga agtgattcat gagaagcctt ggctgtgggc ggtcgttatc ggttttgcac 817861 tgatattgcc gttatcttta gcggtgtcca aaataaaaga ccgcaaagct ggggacgaag 817921 agaatgcgga taaagtgaaa aatccgattt tcgcatatat tggagcttca gttgttgaat 817981 ggctcatggc cgggaccgtc atctattttg ctttgttcgc tatgggcatt catgcagata 818041 tcaggtatgt gttcggggtg ttcgtcattg cggcgatcgg aggaatgatc agcctcgtgc 818101 cgggcggctt cggctcgttt gaccttttat ttttgctggg gatggagcag cttggctatc 818161 atcaagaggc catcgttact tctattgtgt tgtacaggct cgcctactca tttatcccat 818221 ttatcttggg actgttcttt gccgccggcg acctgacgga aaatacaatg aagcggctcg 818281 aaacgaaccc gcgcatcgca ccggcaattg agacgacaaa cgttctgctt gttgttcagc 818341 gtgcggtatt agtgagaatt ttgcaaggct cgctttccct tattgtgttc gtagcaggtc 818401 tgattgtctt ggcctcagtt tccttgccga ttgacaggct gacggttata ccgcacattc 818461 cgcgcccggc gcttttgctg ttcaacggcc tgtccttaag ctcagcgctc attctgctca 818521 ttttgccgat cgagctttat aaacggacaa aacgttccta cacgatggcc attacagcgc 818581 ttgtcggcgg ctttgtgttc agctttttaa aagggcttaa catcagcgcg atattcgtac 818641 tgccgatgat tatcgtattg cttgtgctat tgaaaaaaca atttgtccgc gaacaggcat 818701 cctatacact gggacaattg atattcgctg tggcgctgtt tactgtggcg ctctttaact 818761 acaatctgat cgcgggcttt atttgggacc ggatgaagaa ggtgctgcgt cacgaatatt 818821 tcgtccacag cacctcgcat attacacatg caaccatcat ggcgatcatc attgtgccgc 818881 tgttcttctt gatatttaca gtggtctatc ataagagaac gaaaccgatc ggagagaaag 818941 ctgaccctga gcgtcttgct gcgtttctca atgaaaaagg cggcaacgcg ctgagccatc 819001 ttggttttct tggagataag cggttttatt tttctagcga tggaaatgca ctgcttctgt 819061 ttgggaaaat cgccagaagg ctggtcgtgc tcggcgatcc atctggccaa agagaatcat 819121 tcccgctcgt gctggaagaa tttctgaacg aagcgcatca gaagggattc agtgttttgt 819181 tctatcaaat tgaacgagag gacatggcgc tgtatcacga ttttggctac aacttcttta 819241 aattgggtga ggaagcatat gtagatttaa atacatttac cttgactggg aagaaaaaag 819301 ccggccttcg ggcaatcaat aaccgctttg agcgggagga gtatactttc catgtggatc 819361 atcccccatt ttctgatgcg tttttggagg agctgaagca aatctcagac gaatggctcg 819421 gctcgaaaaa agagaaggga ttctcgctcg gattttttga tccttcctat ttacagaaag 819481 cgccgatcgc ctatatgaaa aatgcagaag gagagatcgt tgcattcgca aatgtcatgc 819541 cgatgtacca ggaaggagag atatcggtcg atctgatgcg ctatcgcggc gacgctccaa 819601 atggcattat ggacgcattg tttatccgta tgtttttatg ggcaaaggaa gagggctgta 819661 cgtcatttaa tatggggatg gcacccttgg ccaatgtcgg cactgccttt acatccttct 819721 ggtccgaaag gtttgccgct gtcattttta ataatgtcag atacatgtac agtttcagcg 819781 gcctaagagc ctttaaagaa aaatataaac cggagtggcg agggaaatac ttagcgtatc 819841 ggaaaaacag atctctttct gtcaccatgt tcctcgttac acgtctgatt ggcaaaagca 819901 aaaaagactc cgtctaataa gacggagtct ttttttattt cgtttttaag aagtaggttt 819961 caatatcatc aagcaggtag tttgcggctt taattccgcc tgcggttgtc catacgacgt 820021 catcgacttc atgtgcatta cctgacttca cggccttcag gtttttccat agtgaactgc 820081 ttgtccactg attggcccat ttttcatttt cttttgcatt atcggcttta taagtgaaat 820141 aaaacagcac atcagcatcc atatcaggaa tagattcttt actgtcggtt gagaacgtaa 820201 attggtcctt ttgtttctta aacagttcca cttgtttttc agggcgtttg aagccaagct 820261 ggtctaaaat aatcccagga aatgaatcgg tataatagat tcttgattca ccggataaaa 820321 agcgtacgac tgaaacggtt ttgtttgtct ggtcgcccag cttgtttttt aaatcagaaa 820381 cacgtttatc aaaatcggca atgacttcct tgcctttgtc cgccttattc accgcgttgg 820441 cgtatagagt caggttatcc ttccagttcc cggccaaaga ttcagcaaaa acagtcggcg 820501 caatcgcatt taactgatca taaatttttt cctggcgcac tttgtttcca ataatcaaat 820561 caggctttaa ttctgcgatg gcttccacat tcggttccgt ttcaagaccg acgtttttaa 820621 cacctttcat gtcatctttc agatagtcat accacgggtc gcccttccat gactttacgg 820681 ctccgaccgg cttaatgcca agcgctaaga gcgcctctgt tccttcatta gttaaaacaa 820741 caatccgttt tggattggcg gggatgttgt ctgatgtccc cattgcatgt ttgaccgttc 820801 ttgttttgct gcttgacacc tcgctgttgc ttgaactttc tgaactatta caggcagaaa 820861 gtaccataac ggccattaaa aatacgaata gcatgctgat atgctttttc atctttttcc 820921 tcccaatatt gaaattcatt atcatttaga tcataataag cagtgttaag agtgtcaatc 820981 cctaattgag gattattctc aaaaacaaac attacatagt aaataactag gagaattaga 821041 tcatgatctg caaaaaggca tcttcaaaat ggattgtgtt agtatgtctg attttcattt 821101 tactgacggc tgtctgcgca agcgtcgtgt atggctatac aggtacgtca tggagacagg 821161 tctatcaggc gtttacttcc ttcaatggaa caaatgagca tgtcatcatc aaggatgtca 821221 ggcttccgcg cgctttggtt gcgacagtcg tcggcgcctc gcttgcagcc gcgggcgctc 821281 tcatgcaggc gctcacaaaa aatccgcttg cgtcaccggg gattttcggg attaacgccg 821341 gtgcaggttt ttttattgtt gccggatcgt tttttctgca tattcagtca cctcaggcat 821401 tagtatggag ctcgtttctg ggggcagcat ttaccgctgc gatcgtctat gcagcaggct 821461 cgcttgggag ggaagggctg acgccaatca aactgacgct ggcgggagct gccatggcag 821521 ccatgttttc ttctctgaca cagggcttgc tgtctgtcaa cgaactcgag cttgcccagg 821581 tgcttttttg gctgactggc tctgtgcagg gccggagtct ggatctgttg atgacgatgt 821641 ttccatatgc agcggcagcg ctggtaatct gcttctttct cggccaaaaa attaatctcc 821701 tcgttatggg agaagatgtg gcaaaaggac tcggccaaaa aacaggcctg ctgaaatttg 821761 tgatggcgct ttgtgttgtc atgcttgcag ggtccgctgt cgccattgcc gggccgattt 821821 cttttatcgg catcattatt ccgcattttg cccgctttgt cgttggtaat gattatcgct 821881 gggttctgcc attttccgct gttttgggtg ccattttgct tgtttgcgcg gatatcggtg 821941 cgcgatatat cattatgcct caggaagttc ctgtcggggt catgaccgcc atcatcggaa 822001 tgcctgtgtt tgtgtacatc gcaagaaggg gggcgaagct atgaaacttc gttttggcgt 822061 tactgcggct gaaaagaaag catggatcgt ctttttggtt ttactggggt taacagctgc 822121 tgtactcatc ataagcgctg gtctcggaca aaggtttatt cctccctggg atgtagcaaa 822181 aacattcttt ggtgcaggtt ccaagctgga tgaactgatg atcatgtcgt tccgcatgcc 822241 aagaattttg acggctttat gcgccggtgt ctgcttggca gcggcaggcg cgatattgca 822301 ggggctcgtc agaaaccctc tcgcatctcc ggatattatc ggaataacag gaggagcggc 822361 ggtagcggtc gtgcttttaa tgatgttctt ctcagaccgc agcagttcac ttacgatcag 822421 tctgtcatgg cttccagcag ccgcatttat cggcgcatcg gctgtcgggc tcatcgtcta 822481 tttactggca tacaaaaatg gcgcctccac atttcggctg gtgcttatcg gaatcggatt 822541 ttcaatgtcg gcgcaggcga tgactaccct gttgatgatc aaaggcccga tttaccgagc 822601 atcacaagcc aatgtgtata tcactgggtc agtttatggg tcaaactggc agcatgtaaa 822661 aatagctatt atcttatctg tcattctctt attcatttgt tttgtcgcgc taaaaaatat 822721 gaatatacag gtgctgggtg aagatattgc ggcgggtgca ggaagcgctg tgcagcgaaa 822781 tcgttttttc ttgctccttt tgagtacggc tcttactggt tgtgcagttt cagttgccgg 822841 cacaatcggt tttgtcgggc tgatggcgcc ccatattgca agacggcttg tcggctcatc 822901 ttatggcgcg ctgctcccag cgtcggcact tattggagct ctgctcgttt taacagctga 822961 tatcgtcggc agaaccttat ttgctccggt ggaagtgccg gccggcgtct ttacagcggc 823021 tatcggcgca ccttatttta tttatttgct ctataaaaca agaaattctt aatcgttaca 823081 cccattttct taaaaaagaa aatgggtttt tttgataatg actgaagatt cgtaattatt 823141 tttgctatac tgacagagac attgataaag aaagggcggc agatgaatga aagaagcaga 823201 ggtattaaaa tatgaagcat ttacaagcag tcccggcaaa ggaaaccccg caggcgtcgt 823261 tttgcaggga gacgattata cggaagacga gatgcagatc atagctgaac gtgccgggta 823321 ttcagaaacc tcctttatcc gaaaaagcga gtcggccgat cttgaactcc gttactttac 823381 ccctggacac gaaatgaatt tgtgcggtca tgcgacagtt gcttctcttt acgcattatg 823441 tgagaaagga atgctggaga gcggtaaaac gtacagcatc caaacgaaag cgggtatcct 823501 gcctgtgaag atttctgaaa aagatggccg cattcatatc acgcttgaac aggcctctcc 823561 gcaattcaaa ccatttacag gcgatcggaa aaaacttgcg gacgcactgg gtatcaccga 823621 tgaagatttt catgaagacc ttccgattgt gtttggcagc actgggatat ggacagccat 823681 cgttccgctt aaatcattgg aggcttccaa aaaaatggtg ccagataaca aacaatttcc 823741 ggaagtgtta gttgatctgc caaaagcttc agtccatccg tttacctttg aaaccgtcca 823801 tcccgacagc gacctgcacg ggcgccactt ttcatccccg tattcgggaa cgattgaaga 823861 ccccgtgacc ggcacagcat ccggcgtgat gggggcttat atgaaacatt atggcaatgc 823921 cgagcagcat aaatttatca ttgaacaagg gcaggaaatt ggaaaagacg gaaaagtgga 823981 gatcgaaatg aacgaagccg gcggccatgt gaaagtgaac atgacaggaa cagccgttta 824041 ctcagaaacc cgtattctta aaatctaata cggatgatgg tttacaaaaa gatgcacttt 824101 ccgttatcat tatgaaatga taatcatttt caattgcata ggaaggtgag acggtatgcc 824161 tcaaaccgaa caaatacatc agcattcagt actgagggac atcatacgca gcagaagatc 824221 gattcgaaag tttaaacaag agccagtacc ttcagcagtc attcttgaca tgcttgaaac 824281 ggcaaaatat gcgccaaatc acagagtgac agagccatgg agatttattt acgtttccag 824341 tgagacaggt aaagcgaacc tcattaatac atttgcagcg ttctctaaga aatccaagcc 824401 ggatatgaca gaggaaaagc ttcaaaattt caaaaacaca cttgggcgcg ttccgggatt 824461 tctcctcgtc gtgtttcagg aagatgaaaa cgaaagagcg cgggacgacg attttgcggc 824521 aacaagctcg ttgattcaaa atcttcagct tctcgcttgg gaaaaaggaa tcggcatggt 824581 ttggaaaagc ggaaaaatcc tttatgacaa agaagtccat caggcctttg gtttacagga 824641 taatgagcgt ttcgccgcca tcatacaaac aggttatcct gacgaggcgc cggaagtgaa 824701 aaaacgcaca ccgatccgcg accgattcac tgaaatgtaa aaaacccctt gtctcaaacg 824761 gagacaaggg gtttttcatt aacgagattt ctttttcgct ctgttgtcgg ctgctttcgc 824821 acgctcttgc gcttcgcggt catctgcatc agcaagctcg gttgaatatt cttcgtaaac 824881 gccgtcagtt tcccttttta aggcatcggg aacttgtgga agcttttgtt tgtttttatc 824941 acggtttttg tggatatgat ttctgcccat atcaaattcc ccctaaaaag tgatatcaaa 825001 caaatatagt atttggtttt aaggggctat gtattcctac ttccgcttag cagctttttc 825061 cgctttttta aattcgcctg aataaagaac ttcctgcatt tttttcaggt tggcgccttg 825121 ctggtgcttc tccctctttt tttccataaa aaggacctcc ttcaaccatg ttattcttaa 825181 ggttgacgct tcctgctgtt tttatacagt ctttcggtcc gctatcagct gtgagagtgc 825241 aaattcaaga tccgaatatg taaaacgaaa tccagaggtt atcgcttttt tcggaagagc 825301 gcgctgtcct ttcacaatca aaagactcat ttcacccaat gcttttgata aaaagaattc 825361 cgggacgggg agccagtgcg ggcggtgctt cacccgtgca atcgtttttc cgaattgctt 825421 catgtccaca ggattgggcg cggtgacatt cattgggcct gagatgccgg cgttttccac 825481 cgcatatcgg atcatctggg ccgcatcctc gacatgaatc catgacagcc actgccttcc 825541 cgttccgatc gttccgccgg ccagaaactt ataggggaga atcatgagcg ggagagcgcc 825601 tttttctcca agcatcacgc caaatctcgc ataaactgtc cggatgccca tcgcttcaat 825661 atgctgtcct tccttttccc acaggtgtgc agtatggctg agaaaatcct catctgacgt 825721 tgcagaatcc tctgtgaaag ttttctcaag gcttgtgccg taaatgccca cggcactggc 825781 ttggatcaat gtcttcggct tctccttctg tttctgaata agccgctgca cttcacgcgt 825841 cgcattgata cggctggaga gaatgtgctg cttcgttttt tctgtccagc ggccaaaaat 825901 cgattttccc gcaagattta tccagacatc aatatgagga agttcctgct ccggtgcggc 825961 tccttccgac agccattgga catatgtcat atttttttgt tcagtttccc ttgcgtttct 826021 tgataaaata taaacatggt gtccctggcg ggtaagaacg cctgtcagat gctggccgag 826081 aaaaccggtt ccgcccgtca ttgcgatatt catgaacatc tctcctcatc gttctaataa 826141 atatacttta cctcattgta ataaaagaaa acgcgtttca ggcctgagaa gggagattaa 826201 gatgccgttt attacaaaaa tatcaacgca aaaaaagaat acggaacgct tcaatatttt 826261 tctggatgat aaatacgcct tcagcgtgga cgcggatgtg ctcgtgaaat ttgagctcaa 826321 gaagggaaaa gaactcgatg atcttgacat cattgagatt caatacggcg atgaagtgaa 826381 gaaaggcttc aaccgtgcgc ttgacttttt atcctatcga atgcggtcga cgaaagaggt 826441 cgaggatcac ttaaagaaaa aagaaacctc gccccccgtc attgcggaag tcatccatag 826501 gcttaacgat tacaagtact taaacgacca ggaatttgcc gcagcctatg tcagcactca 826561 caaaaaaaca aacggaaaag gccctgatgt tttgttcaga gagctaagag cgaagggaat 826621 tgatgacgat acaattaagg aggcgctaag ttccttttcc tttgaagatc agacaagaga 826681 agcggtcaag catgttgaaa agcttctcaa aaaagataaa aagctttcga cgaaagaact 826741 caaacagcgc gcccagctgc agcttcagcg caagggcttc tcatttgatg ttatcagcgc 826801 ggcgatggat cagattgaat atgaaaatga tgaagacaca gagaaagaag cgctgcgcct 826861 tcacgcggaa aaagcgttta gaaaataccg ctatgacggc tcatatgaaa gcgccatgaa 826921 ggtcaaacaa tttttattcc gcaaaggatt ctcactcgat ttaatcgagc aattactgca 826981 ggaagaggag tactgaaatg gagaaacgat acagtcaaat gacaccgcat gaactcaata 827041 ccgaaatcgc attactttct gaaaaagcaa gaaaagccga acagcatgga atcataaacg 827101 aactggcagt gctcgaacgg aaaattacga tggcaaaagc atatttgctg aacccggaag 827161 attactcacc gggagaaaca tatcgtgtgg aaaacactga ggacgagttt accatcagtt 827221 atttaaatgg cgttttcgca tggggataca ggacctcttc ccctcagcaa gaggaagcgc 827281 tgccaatctc agtattgcaa gaaaaagaat aaagcgtaac aggaggctga tgatcagcct 827341 ctttttgttt gcagcacatt tacacgaatt cttaaagaaa aaatcattga attcacttga 827401 aaaatctttt aagatgaaac tcgttgtttt ttaaaatcaa aggaggcgat gacgttgagt 827461 atcaaaaacc catctgtaaa atttattata tttgttctta tgatttgtac attttcaatc 827521 ggctatacag aatacgcggt gatgggtatt ttgacgtcga ttgccaatga ctttcatata 827581 caggtttcat ccgcagggct tcttgtcacg gcttatgcgg caagcgtttg tttgacaggg 827641 ccgctcgtca ccatcatttc cgtcaagctt ccgagaaagc ctgtgcttct tgggctgatg 827701 gcgatattta tcctttccaa cctgatgagc gcactggcgc cgaattttgc ggtattggcc 827761 atttcaagaa ttttatctgc gtccattcac ggcgctttct tcgcgattgc catggtattc 827821 gcaagtgaaa tggttccgcc ggaaaagcgt gctgcagctg ctgcttcaat gaacggcgga 827881 ctgacagtgg ctctaatgct tggtgttcca ttcggctctt atctcggaga tgtcctgaat 827941 tggagagcgg tgttttccat cattacggca cttggtgtca tcggattttt aggccttatg 828001 gctgccgtgc cgaacagaaa accaaaagtg atcccaatgc ttatgaatga gtggggtgtt 828061 tttaaacaca aacaagtgct gttttccttc gcgattacca ttttaggcta ttccggtgtc 828121 tttatcgcct acacctttat cgaacccatt ttgaggcatt cagccggatt cagcacggtt 828181 ggcattacag gtgctctctt tgcgtatgga ttgggaggcg ttgccgggaa tttctttgct 828241 ggaaaggtac cgctgccttt gctgactcgg acgatgatcg gcgtaatgat cggtttaatc 828301 ggtgttctgg ctgtatttcc ttacatcgcc atttacccgg ctgcagccat tgtggcaacg 828361 ttcctattcg gggcatgcgc attcggcacg ccgcctcttc tgcaaacaaa ggtcatttcc 828421 tcatctgagg gcggcacaac cattgccgca gctgtcagcg tatcagcatt taaccttgcc 828481 aatgcccttg gtgcatggat cggcggaatg attttaaacg gaacaggctc ttattcctgg 828541 ctgtttgcag gaggtgcgct tatgaccgca tgcggacttg tgctttctac cttcgcacac 828601 ttatcagaaa agaagagcgt ctacgaatat caagtcaata aagggtaaaa aacagctgca 828661 gtgtatgcag ctgttcttct ttaccgtttg cctgaggctc tcattctttc ttgaggatgc 828721 tgattgatag atccgtcagc acgctttgaa gcatagtcgt cctttgctct cggttcaccc 828781 tgaaatttgt tttcgttttc gtaaggaaat cctttttctt tatttcggac catgtcatat 828841 ccccctaggt tcgagatcaa aaagttgcgt cttttcagat gaagacgtaa ggttagtata 828901 tggagaacac cacgtaataa agcgttattt ttttcctgaa gaaaggagac tgcacacatg 828961 aatatgtaca ttgagaaact gactaatctg cttctggaaa agaacgagat gatcagctat 829021 atacaggcaa aaacgtgggt ggaattgtta tggagcgatt tcgaagcaac ctacgcaaaa 829081 gccggacacg cctatcaagg tgaaaaaatg actgaaaaaa tcgtcacaca atggattgaa 829141 aactatggcg gccagctcca cctttttcaa agctcccgta acgacgtgaa tgattactta 829201 aatcaaagca gaggcctttt gcattaaaaa cctgccgtta acgaccggca ggttttttca 829261 ttttcttaaa attaccttaa caggaagaaa tcataaacaa aacatgtttc accagcctgt 829321 caatcaggga ataccactta tatcttgtca aaatgcgagg aggagcttta tatgaaaaag 829381 aaacaagtaa tgctcgcttt aacagctgcc gcaggactgg gtttgacagc acttcattcc 829441 gctcccgcag caaaagctgc gccccttcac gacatatctg tcagcatgcc atcatccgat 829501 acttacatca taaaagcagg aaagctgaat gtccggactg agccaaatca tgaaggtgat 829561 attctcggca ctgtatcatc agaacaaaag gtaaaagtcg ataggttcgt aaatgccgat 829621 tgggctcaaa ttcatttcaa aggaaagaaa gcatatattt caactcactt tttaatgaaa 829681 accgcaagcc aagcgaaaac aacgaaacag acagccttct atacaccgac gcccgaaaac 829741 ggaaaagcta agcagctctc atctggaaca gaggtgacaa tacttgggtg gggattcagt 829801 gaaaacggcg gatttgactt cacttgggcg ttcgtggatt atggcggagt taaaggctat 829861 attcacacaa aggatttaca aatgcgataa aaaggcaggc cgaggcttgt ctttttgcct 829921 atgcatgaaa catttcttct ttctgcacgt aacaatgaga aaggagatga tgatatgacg 829981 ggtttagtcg gcggagggct tatgatcatt gcgggcatac tgatcaaact gtttcctccc 830041 aaatcgatca acagtgtgta cggatacaga acgagacgct caatgtcaga tcaaagatta 830101 tggaatgaag cgaaccgtta cagtgcatca ttaatgatcc tgtcaggctt ggtgattgcg 830161 ggaatgggtt tgctgctggg atcaaacttg tttattcttc agcttatcct gctgattgcc 830221 gcctgtgtca taacatttat gctaacggag aaaaggctga aaatcatgac gcacagtcaa 830281 ggaggagata gaagtggacg gagttaaatg ccagtttgtc aatacgaacg gaatcacgct 830341 tcacgttgca gccgcaggac gggaagatgg cccgttaatt gtcctgctcc atggatttcc 830401 tgagttttgg tacggctgga aaaatcaaat caaaccgctt gttgatgcgg gttaccgggt 830461 cattgctcct gatcagcggg gctacaatct cagtgacaaa ccggaaggaa ttgattcgta 830521 tcggattgat acattaagag atgatatcat cgggcttatt acgcaattca ctgatgaaaa 830581 agcaattgtc atcggtcatg actggggagg agctgtcgca tggcatttgg cttccacacg 830641 cccggaatat cttgaaaaac tgatcgcgat caatatcccg cacccgcacg tcatgaaaac 830701 cgtaacgccg ctttatccgc cgcaatggct gaaaagctcg tatatcgcat acttccagct 830761 gcccgatata ccggaggcat cactaaggga aaatgattat gatacattag acaaagcgat 830821 tggattatcc gaccgtcccg cgctttttac atccgaggat gtcagcaggt acaaagaagc 830881 gtggaagcag ccgggcgcgc tgacagctat gctgaactgg tacagagccc tcagaaaagg 830941 aagcttggca gagaaaccct cttacgaaac agtaccttac cgaatgatct ggggaatgga 831001 agaccgcttt ttgagcagaa agcttgcgaa agagacggaa aggcattgcc cgaatggaca 831061 tctcatcttt gttgatgaag cttcccattg gattaaccac gaaaagccag ccatcgtcaa 831121 tcagctgatt ttggaatatc ttaagaacca ataagctaaa atttctctcc atccgtctgt 831181 cataatggca gactttttct gtgcgttttt tttcatagtc tgttttaaac atgacaaaat 831241 aacattaaaa atcatgaatg tcaccataaa attgtaacaa aaaacaggtt taaacgactt 831301 taaaaaaagg aatagcctta ctgaagattt gtgtaaaact cccctaaggc aatacttaaa 831361 aagaataata aaaagaaggt gccttaatga agcaaggatt aatctcgatt attatcccgt 831421 cttacaatga agggtataat gttaaactca ttcatgaatc tttaaaaaag gaatttaaaa 831481 acattcatta tgactatgaa atattcttca taaacgacgg aagtgttgat gacacgcttc 831541 agcagatcaa agacttggca gcgacgtgca gccgggtaaa atatatatct ttttctcgaa 831601 actttggaaa agaagccgca attttggcgg gctttgagca tgttcagggc gaggcggtta 831661 ttgtcatgga tgccgatctg cagcatccga catatttgct gaaggaattt atcaaaggct 831721 acgaagaagg gtatgaccaa gtcattgccc aaaggaacag aaaaggggac agctttgtcc 831781 gctcactctt atcatctatg tattacaagt tcattaataa agcggtggaa gtcgatttgc 831841 gtgacggtgt cggtgacttc agattgttaa gccgccaagc tgtgaatgca cttttgaagc 831901 tgagcgaagg aaaccgcttc tcaaaaggcc ttttttgctg gattggcttt gatcagaaaa 831961 ttgtatttta tgaaaatgtc gaacgaaaaa acggcacctc caaatggtcg ttcagcagtc 832021 tgtttaacta cggaatggac ggcgtcgttt catttaatca taagccgctg agattatgtt 832081 tttatacagg cattttcatc ctgctgcttt ccatcattta tatcattgcc acattcgtta 832141 aaattctgac taacggtatt tctgtgcctg ggtatttcac cattatctca gcagtgttat 832201 ttctcggcgg agtacagctg ttaagtcttg gaataatagg tgaatatatc ggccgaatct 832261 attatgaaac aaaaaaacgc ccgcattatt tgatcaaaga ggcgaatatc ccgaacaaag 832321 acctgcctga aacgaacgaa ttaaaaagca tgcggcgtct gacaaaaatg cactgaaaat 832381 accaagcgcc attggcagtg ctttttttgc gtgtctatta tcttaaaagc aagactggag 832441 aattcatatg aaaagaaaac atatcatgat ctatgcggcc agtttgctgg tgtccgttct 832501 ggcacacgct ttttttgtga aagaatgggc ggaaggcagg tatatgacag gtccgggtga 832561 cgggcttgcg caaatgatcg tatttaaaaa attattattt gaccaatata cacacgggaa 832621 ttttttctac aattattcat tcggacttgg cggcggcaca ttcagtcagc tcggctatta 832681 tttttctgcg tcttttcttt ttcttgctgt gtctgccgct gtttggctgc ttcaagccgt 832741 ccagctgatc ggagaaacgg atacgctttt ttgggcagag tcagctgttt ttatcagtat 832801 tttcaaattg agcttgatca tctttacgtc cgcttctgtt tttcattatc ttcttaagca 832861 cagggcggca tcgttcacgg gagccgtgtt atacggcgtc tcaattattt atttccgtca 832921 cgaagcgtat tgggaatttt tcaccgatac aatggtttgg cttccgctgc ttgtgcttgg 832981 cgcagaaaaa attattagag agcggcgtcc ggcgtggttt atcgttgcgt gttcgctgac 833041 gttaatcaac aatttttact ttgcatacat aaaccttata ttcatcggaa tctatgtgct 833101 gttcagatgg ctgatccgtt tggaaccaca tgaagagaaa agatggattc aaatcagatt 833161 atttctcgtt tcaggcttca tttcttttgg catcagtgcg gcggcgtttg tgccggtagt 833221 atacggtttt ttaaacaacc tgcgccctcc atacagccag aaaatagagt ggctcaattt 833281 cgatgataat atcttatttt cgagccggat catcattgtg ccggccgctt ttctgctgtt 833341 tttgtttatt atttcttttt acaaaaaccg tgtgtttcgt ctctttgccg ggttgagcct 833401 gctgtttatt ctgtttcatt tcagtccgta tgcggcaagc gtctttaacg gtttttccgc 833461 cccgcaaaac cggtttgaat atgttctggc ctttaccatt gcgggagcag ctgcggctgg 833521 tttgtcacag ctgtctgaat tgaaacggaa agaactgctc ccggccgcag ctgtcgtcct 833581 gcttctttac ttgtatcata tccaaaggta taagctcgat atatggaagc ctgcgaatga 833641 aagtattcta ttgctcttac tcatgacaat cgcagccttg tttgctgcag cttttgcgaa 833701 aaaacgggca aaaatggctg tgtacggtat aatcattctt tcttcgctgt ttgtcgccaa 833761 ctcctatcaa aaatacgcgc tctcagaagg cggcgatttg gacagtgtga caaaagaata 833821 tcttacaagt gaggaataca gagggcggga atcatctgag ctcatcagac gtttacagaa 833881 ggaagacgat gacccgctca tgagaatcga ctggatgaac ggggtccgca ataatacgcc 833941 aatcatttac ggatttaatg gcttcagcgc gtattccagc attttaaaca aagatctgct 834001 ggccttctat tggaatgatt taagcatcga tatgggcagg gaaagcgtca gccgttacgc 834061 gtcattggga gacagggcga atttatacag cctgctttac ggcaaatatt atatgaccga 834121 aaaaacaaac gaagccagcg tcccgtacgg cttcaaaaag catttagaaa cagagcatta 834181 tgcagtttat gagaatcagt acatgcttcc attcgttaaa acagcggatg ccatatacag 834241 cgaaagtgag ctggaccgat tgcccgctct tgcgaaagaa caggcgatgc tgaaaggaat 834301 tatattaaaa gatccatcag gaaaaacgga gcagacacca aaaccgtcca atttgatcac 834361 caagtcggac atcaccgcaa aacaagccca gtatcaaaac gggctgctaa ccgtaactgg 834421 agaaaacgga ggagagctga tcatcacccc gaaacagcca tcatccgctc cgggagacta 834481 ctatgtcagc ttttatttga aaagcaaagc aaaagacaaa ggatttacat taaaggtaaa 834541 tgattatgtc acaacaagga aatcgaacaa atcgatctat aaaaccggag taaataatat 834601 aacggtaaga gtgcctaaat caggccatat ctcaatcaat cttccgaaag gaacctatga 834661 gctgagaaac atagcgctct atgaagaaaa ttaccaaacg ctgaaaaacg ctgtaatgca 834721 aaataaaaca gagaaagcag acaaactgaa ttggaacaaa aatcgactga ccttttccta 834781 tcatctgtca aaagaccagt acatcatgct tccgatccca tatgaaaaag gctgggagct 834841 gaagatcaac ggaaaaacac agaagatcga aaaagcggat tatgctttta taggcttcaa 834901 ggcgcaaaag ggagacaatc acattgagct gacttactat ccgccatact tcaaaatatc 834961 ggcgatcata tctctcgtca gtctgctgct tgctgttttt tatataagac gtaaaaagcc 835021 cggctctata tagagccgag ctttaatttt ttctgaagtt tttcttcgct gaatatccat 835081 cccgtatagg atgaacgaat cgtgagatca tggccgatat gaacaattgc gacaaacgga 835141 taatggcctt tgctccgata acgcaggtcg ataaatctca cctcataatg atctttaaac 835201 gtatccactt cccaccggta taccggagaa aaggacagaa acgccgcgat gttatcatcc 835261 tgctttgccg catgcattac atcggtttca ggaacaggca cccgattaaa tgtatccaga 835321 atcacgacat gtccttccat gcttcttcct acatagaaag catgtgctgt cgtcactgcg 835381 attcgccatt gcctgaattt catcgttgga gaaataataa tgctttcgat ctcatcatga 835441 atcatctcat gaagcttccg tttaattctc agctgcatga tcaggcgcac caagtagtag 835501 cctaccaata tgatatataa gctgagaaac gtgatgccgg gactcccgcc tgcataccaa 835561 atcgcgatag ctgccagatg gctgataaaa ataaacggat caaacgtatt aatcagcccg 835621 agcgcaaccc attttttcga aaacggacga atggcttgtg ttccataggc gttgaatata 835681 tcaacaaaga catgcagaac gactgccagc agtgtccaca gccacaggtg cagaaaatcg 835741 gcctgaggat aaaataaata cagaatcgcc gggatgatga cagaccaaaa caaaacggcg 835801 ggaattgaat gggtaaatcc tctgtgattc cttatataaa cagcattgtt tttaagcttt 835861 aacacagtat caatatccgg agcctgagag cccgcaagcg ttgcgatcat aacagcgtga 835921 gccattgccg gatctgatcc gacaacagga tcaagcgtcg caataccgcc cagtgcgatg 835981 cccataacga catgtgtgcc cgtatccata ggtgacctcc ttgcagggtg atcctgcaca 836041 ttcactttgt aagaaattcc ccattttcat atacccaatt tttaaactga ttcaatcgtt 836101 ctcatatgtt tccgcttttt ctttattact atttaatgta acatattatc gtactgtgcc 836161 cttagtgtac aacaaaaaac agtctaaaga aaagcggggc gcgaaagact ggggagaaac 836221 acatatgaac gtacttgaag acaaattaaa acaaaaagac atacagcaat ttcgcgatga 836281 tttaatctca tggtttgaac gagagcagcg cgttttgccg tggagagagg accaagatcc 836341 atataaggtg tgggtatctg aagtgatgct gcagcaaacg agagtagaga cagtgattcc 836401 ttactttctc cggtttgtag aacaattccc gacagtggaa gcgctcgctg atgctgatga 836461 agaaaaggtg ctgaaagcat gggaagggct cggctattat tcgcgagtca gaaacctgca 836521 aagcgcggta aaagaagtga aacaggaata cggcggcatt gttcctccag acgagaaaga 836581 ttttggcggg ttaaaaggcg tcggccctta tacaaaggga gcggtgctca gcattgccta 836641 caataaaccc attcccgcgg ttgacggaaa tgtgatgcgt gtcatgtcca ggattctatc 836701 tatttgggat gatattgcca aaccaaaaac aagaacgatc tttgaagacg ccatacgagc 836761 ttttatttcc aaagaaaaac catctgaatt taatcagggc ttgatggagc ttggagcctt 836821 gatctgtacg ccaaaatcac cctcatgcct gctttgcccg gttcagcagc attgctcagc 836881 atttgaagaa ggcactgaac gggagcttcc ggtaaaaagc aaaaagaaaa agcccgggat 836941 caaaaccatg gccgcgatcg tactgactga tgaagacgga caagtgtata tccacaaacg 837001 gccgtctaaa ggtttgctcg ccaacctgtg ggaattcccg aatcttgaaa cacaaaaagg 837061 gatcaaaact gagcgtgaac agctcattgc tttcttagaa aacgaatatg gcatacaagc 837121 tgatatcagt gatctgcaag gtgtagtcga gcatgttttc acccacctgg tatggaatat 837181 ttcagtgttt ttcggtaaag taaaacaagt gtcggatacc agcaagctga aaaaagtaac 837241 gaaagaagag ctcgaacaat ttgcgttccc ggtgtcacat caaaaaatct ggaagatggc 837301 aggagaagca gccgccatct cggctgctcc gtaaaccatt cttaatcgta agagacgcgc 837361 gtgccgtggc tgtagtccgc ttcattgcgc ttcattccgc cgcgcgcttc aatttcttgc 837421 gttaattccc ggtattttga ttggccttct tcgttcaaat aaggcataat ttgctgaaag 837481 gcatgatgaa aataagcgag ttcactgttc ttccaatctt ttttggaaac catgttcaat 837541 tcgctcatat cacgtccgac atacataaca gaagaccccc tttaaagttc ttgccattat 837601 tgtttgtgga aataaaagaa ctatacgcta caaggagatg aggaaaaatg gaacaaaata 837661 aatgtgcact cgtaacagga agcagccgcg gtgtcggaaa agcggccgcg atcagacttg 837721 ctgagaacgg ctataacatc gtcattaact atgcacgcag caaaaaagca gcattagaaa 837781 cagcggaaga aatcgaaaag cttggcgtta aagtgcttgt cgtaaaagca aacgtaggac 837841 agcctgcaaa aatcaaagaa atgtttcagc aaattgatga aacgttcggc agacttgatg 837901 tttttgtcaa taatgccgct tcaggagtac taagacctgt catggaatta gaagaaacac 837961 actgggactg gacgatgaac attaatgcga aagcattgct tttctgcgct caggaagctg 838021 ccaagctaat ggagaagaac ggtggcgggc atattgtcag cattagttca ttaggctcta 838081 tccgctatct tgaaaactac accacggtcg gtgtatcaaa agcagcgtta gaggctttaa 838141 cccgttatct tgccgttgag ctttcaccaa aacaaattat cgtcaatgct gtttcaggcg 838201 gagcgatcga cacagatgcg ctgaagcact tcccgaatag agaagatctg cttgaggatg 838261 cgcgccaaaa tacgccggcg ggacgcatgg tcgaaattaa agacatggtt gatactgtgg 838321 agtttctagt gtcttccaag gctgacatga tccgcggaca gacaattatc gttgacggcg 838381 gacgctcact gctcgtttaa aaatttttaa aaaagaggaa tagctatacg atcacctgca 838441 cattctaatg accgtggagg tgataacaat ggctaactca aataacttca gcaaaacaaa 838501 cgctcaacaa gttagaaaac aaaaccaaca atcagctgct ggtcaaggtc aatttggcac 838561 tgaatttgct agcgaaacaa acgctcagca agtcagaaaa caaaaccagc aatcagctgg 838621 acaacaaggt caattcggca ctgaattcgc tagtgaaact gacgcacagc aggtaagaca 838681 gcaaaaccaa tctgctgaac aaaacaaaca acaaaacagc taatcactga aacagaaaaa 838741 agcacttcat cttcgggtgg aagtgctttt ttctgtttga aaaacgacaa aacttgtgga 838801 aggtctacag aatgagtcaa agggtttgct ttatggagat cgaaatgatt aaaggaggaa 838861 atgtttatac tttcatcagg ctgaaggagg aaccgatgac cgaatttgaa aagctggtaa 838921 gtgaacagat gaaaacgatg gataagcttc tcgatctcca atcagagctc gaccgctgca 838981 aacaaattga ggcggaactc cggcatttgg aaagggatgc aaggctgcgt gggattcagg 839041 ctgaaattgc ggtaaaacgg aaacaccttg ccgatataca ggatatgttt caaaagcaga 839101 cagagcaggt cattcgttca tatcgcagct cagaaaagcc gtcttccttt gtgtagtgca 839161 ggaatgtgcc attccccggc cggaatggct cttttatttt catttttcaa tttgtaacgt 839221 tataataggt aaaagacgtt gtcggtaagc aaatttggac atactaactg tagggcttta 839281 tagaaagtag gggagaaata tgggctatcc caaggaagga gaaaccattc aaattcacag 839341 ctataagcac aacgggctga ttcatagaat ttggaatgag acaacaatct taaaaagtac 839401 agaaatgtgt gtcatcggag ccaatgaccg gacgatggta accgaatcag acggccggac 839461 atggataacc agagagcccg caatctgtta ttttcacgca agacaatggt ttaatgtcat 839521 cgggatgctg agggaagacg gggttcatta ttattgcaac atcagttctc cgtttgccta 839581 tgatggcgaa gcaattaaat atattgatta tgacttagat gttaaggttt ttcctgacat 839641 gacctacaat attctcgatg aagacgaata tgatgatcat cggaaagcca tgaattatcc 839701 aaaagaaatc gacagtattt taagagacta cttaaatacg ctgctccatt ggattcacca 839761 gcgtcaggga ccgtttgcgc ccgagtttgt cgatatgtgg tatgaacggt atttgcgcta 839821 tacaaaataa tggttacgta aaaacctgtt gcggggtaca acaggttttt cacatgggct 839881 cacacacatc atgataaaga gagaggggga atcaaccgtg ggggttatga aacgctacat 839941 gcaattcgtc aaaccttata agaagcaaat tttcgttaca gtgttaatcg ggatcgtaaa 840001 attctccatt ccgcttgctc tcccattgct tctgaagtac gtagttgacg acattattca 840061 aggaggcggc acggccagtg acaaaaccac gtcattgttc acgattatgg cgatcatgtt 840121 cgccttattt ttaattttgc gcccgcctgt tgaatattac cggcaatatt ttgcccagtg 840181 gactgccagc aaggtgcttt atgatataag agctaagctg tttgaccata tacaaaaact 840241 gagccttcgt ttttacgcga atacaagaac aggggaagtc atttcccgag tgattaatga 840301 tgtagaacaa acaaaggatt tcgtcatcac agggctgatg aatatatggc tcgatatgct 840361 gacgattttg attgtaatct ctatcatgct cacactggac gttaaattaa cgctgatctc 840421 tatcgtttta ttcccattat acggaatatc agtgaagtat ttttacggcc gtttacgaaa 840481 gctgacaagg gagcgctcac aggctcttgc tcaagtgcag gggcatttgc atgaacgcat 840541 tcaaggcatg cctgtcatca gaagctttgc gatagaagat catgaacagg ctcaatttaa 840601 tgagaaaaac ggtcatttct tagataaagc catccgccac acgaattgga acgcgaaaac 840661 ctttgcggtc gttaatacca ttacagattt ggcgccgctc atcgtcatag cgtgcgccgg 840721 gtattttgtc attaatggac cgctgacagt cggaacaatg gtcgcgtttg tcggatatat 840781 tgacagaatg tacaaccctg ttagaaggct gatcaattcc tctacaactt tgacacagtc 840841 aatcgcatca atggacaggg tgtttgaatt tattgacgag ccctatgaac tcactgacaa 840901 accaaatgcg ataaaggccg atcagattcg cggaggagtg gagtttcaaa acgtttcgtt 840961 tcaatatgag aaggacaaag aaaatattct tcatgatgta tccttaaaag taaatagagg 841021 agaaactgta gctctcgtcg gcatgagcgg aggaggaaaa tcaacgctcg tcagcctgat 841081 cccaagattt tatgatgtaa caagcggcag actgctgatt gatgggacgg atattcgcga 841141 ttatgaagca agaagccttc gcaaccaggt tggtatggtg cttcaagata cctttttatt 841201 tagtgaaacg attcgggaaa atatcgcgat cggcaagcct gatgccacac ttgaagagat 841261 aatcgaagcc gccaaagctg caaatgccca tgaatttatc atgagttttc cagaaggata 841321 tgagacccgg gtgggggaac gaggcgttaa gctttcaggc ggacaaaagc agcggatctc 841381 aattgcgcgg gtattcctga aaaatccgcc gctcctcatt ttagatgaag ctacatcagc 841441 tctggatttg gaaagtgagc attacattca agaagcgatg gacaaactgg cgaaggatag 841501 aacaactttt gttgtcgccc accgtttatc gacaatcacc catgcggata agattgttgt 841561 catggaaaac gggacaatca ttgaaatcgg aacccatgat gaactcatgg actatgagag 841621 ccaatacaag cacttattta ccattcaaaa tttgaactaa aacatcaatc ttatatcctt 841681 ttaacgaagg atataagatt tttttgtata taaaaaaacc cggctgttta accgggttac 841741 tcttctgttt ctatttcgca gtctttcgga tgatacgttt gaaaacttgt gataagtgtt 841801 tctaaatgtt caagctgctc gcgatattcc acggcgcttg ccataatatt gagcatgttg 841861 taatcaataa gctcctcatc cgtattctgc tgatttttta aaaatgactt tgttaaaagc 841921 tgcttatacc ggatgccttc ttcaaccgcg tcatcatgcg gcttgatttt tccgacaaac 841981 ctcatcaaaa tccgctcgtg ccagtaaagc aggtaatcaa gttcttcagt caatgtttcc 842041 tgaaactctt ccggcatatg atagatctcg ttttccagac gatgcagctt cttcaatgta 842101 tcaagcgccc gatttgcagt aataatggcc tgtctgaaca ggacaagctt tcttgatttc 842161 acataagtcg ttttcttaaa gtaacttctt tcttctttat atagaagata tgtctgatca 842221 agcttgatca ttttttcttt cagtttttca atatcctctt tcaaaatcga atgctctgtc 842281 gactgccgca tggacaatct gatccacttc ataatttctt cggtgttttc gacggtatta 842341 tgaatcagct ttgtttcgta cttaggaggc aaaaacacaa ggttgacgat aaaggaagaa 842401 agcaccccta agatgactgt gcttgttctg atcagcgcga acattaaaaa gtcgtcaccg 842461 gcagattcta atatcgcaat gactgttaca agagcaattg aaattgtatg ttcaatttta 842521 agtttcagca tgattgtaat gacaataact gctgttaacc cgatcataat cgggctgggt 842581 ccgaaaataa ggccgaacac tgtggcaatc acagctccga tgatatttgc ttgaacctgg 842641 tcaataataa tgagaaaaga gcggtaaatc gacggctgga tcgcaaatat cgctgcaatt 842701 ccagcgaaaa tcggcgcggg aagcccgatc cacgaagcca aataaagggc aagtgtaatc 842761 gcaatcccgg ttttgaaaat gcgggcacca agtttcattg gtttgtgcgt gcattccttt 842821 ctatagtaaa ttgtgtgaca tagcaaatgg gctaatcctt aaaattcccg gttagtttat 842881 ttgctaaaca attaagtaat atacagggat cgatacaaat attcaagcta tttttctaga 842941 aaaagaccaa aatcttacac gctgtttgat tccataaaaa aacaggagct caaagctcct 843001 gttcaaggta tttgattcta gttttttaga tgtttaaatg catcctcgac cgctgtaagc 843061 gtgtctttaa tatcctgctc tgtatgtgct gtggtaataa accaagcttc atacttagaa 843121 ggtgctaaat taattccgcg ttccagcatc agcttgaaaa acgtagagaa tgtttctccg 843181 tcactccgtt cagcctgctc gtaattttcc actttctcat cagagaagta taccgtgagc 843241 gcacctttta accggttgac cgtaatggtg atgccgtgtg tttctgcgtg cttcaaaatg 843301 ccttcctcaa gcatagcgcc aaggtgatca agcttttcat acacgccttt ttctttgagc 843361 acttccagac aagcgatgcc tgataggatg gaagcggggt tccctgccat tgttcctgcc 843421 tgataagcag gccctagcgg agctacctgc tccatgattt cttgtttgcc gccataggcc 843481 ccaatcggaa gtccgccgcc gataattttc ccgagtgctg ttaaatctgg tttcacctgt 843541 aagagatcct gcgcgccgcc atacataaag cggaaagccg taatgacttc atcgtaaata 843601 acgagagccc ctgcattatg tgttaattca tttacttgtt ctaagaagcc ctctttcggc 843661 tccacgatac cgaagttgcc gacaatcggt tcaacgagaa ccgccgcgat ttcactgccc 843721 catttttcaa gagctgcttt atagctatcg atatcattaa atggtactgt gatcacttcg 843781 tttgcaatgc ttttcggtac accggctgag tctggtgtgc cgagagtaga cgggccggag 843841 cctgcggcga caagcacaag gtccgaatgc ccgtgatagc agcccgcaaa tttaatgatt 843901 tttgtccggc ctgtatatgc gcgagccacg cggatggtcg tcataacggc ttctgtaccc 843961 gaattgacga atcttacttt gtccatagcg ggaatggctt ctttgagcat ttttgcaaat 844021 gtaacctcgt gtttcgttgg tgttccatac aatacaccgt tctctgctgc ttttttaatc 844081 gcttctgtaa tatgcggatg ggcatgtcct gtaataatcg gaccgtacgc cgctaaataa 844141 tcgatgtatt tgttgccgtc cacatcccaa aaataagcgc cgcttgcttt ctccattgca 844201 acaggagaac cgccgccgac tgctttatat gatctagacg ggctgtttac accgccgaca 844261 atgtgctgta atgcctcatt gtgaagttca attgattttg tatgcaagaa taaaaacctc 844321 ctatatctcc atgcgtcctt tctattgtag catgcttccg aacaagaaca atggcttcgg 844381 gcttcagatt cagctgagat ggttgtaatc tggacaagaa ttggatacgc ttaataaaaa 844441 aacatccgga ggtaacgtaa tgactataga aatcggacaa aaagcgcctg atcttgagtt 844501 aaaaggtgat catggggaaa cagtaaaatt atcggattat aaaggaaagt acatcgtgct 844561 ttatttttat ccaaaggaca tgacaccggg atgtacaact gaagcatgcg attttcggga 844621 cagtcacgaa agcttcgccg aactggatgc cgtcattatc ggcgtcagcc cggacagcca 844681 ggaaaaacac ggaaaattta aagagaagca taaccttcca tttctgcttc ttgttgatga 844741 cgagcataag ctggcggaag catttgatgt gtggaagctg aagaaaaact tcggaaaaga 844801 gtatatggga atcgagcgtt ccactttttt aattgataaa gaaggccggc tcattaaaga 844861 atggagaaaa gtaaaagtaa aggaccatgt agccgaagcg cttcaaaccc tcaaagatat 844921 gtctgaaaag taaatctcta tgagcctatg cttactttta ccctgatatc aattgacaaa 844981 ttatcgtaga aagagttaca ctaattataa acattacaat gtaagaattt tttttagaag 845041 agaggtgcat gacggatggc tgcacatgaa ctaaaagaag ccttagaaac gttgaaggaa 845101 accggagttc gcattactcc tcaacgtcat gcgattctgg aatatctcgt taactctatg 845161 gctcatccaa cagcggacga tatatataaa gctctggaag ggaaatttcc taacatgagc 845221 gtagcgacgg tatataacaa tttgcgtgtg ttccgggaat caggtttggt aaaagagctc 845281 acatacggtg atgcttccag cagattcgat tttgtcacat ccgatcacta tcacgcgatt 845341 tgcgaaaact gcggtaaaat tgtggacttc cactacccgg gccttgatga agtggagcag 845401 ctcgctgccc acgtcacggg cttcaaggta agccaccacc gtttagaaat ttacggcgtc 845461 tgccaagagt gttcgaaaaa agaaaatcat taaaaataag ctgaccgcac gaaacggtca 845521 gcttatttta tttcgacatt ttctttttat tataagactc atcaaattct tttccttcta 845581 atcccttatc taaagtcagc ggctctcggc aatgcatgca catatcgact actcctaaaa 845641 cctttgtctc tttatcacag cctggacaaa tgacgcgaac cgctttagtc gaaagcattc 845701 cgatccaaaa gtaaactacc gtgctgagac cgatggataa aagcccaagt atcataaaca 845761 aactagaaag caaaactgac tctttgaaaa agatcccgat gtacataatg ataaacccaa 845821 cgaaaaccaa acttaacgca aatgttctga ttttattaat tttgctggag tatttcgcca 845881 tgtccatccc cctctgtttt aactatagca caaacccgat gggattttct tcatgttttc 845941 ggttgaactg gaatttacat atggagagtt actgtgaaat tgtttataat agttcaatgt 846001 gtttagaaaa aaggaatttc gttttaacca tagaattgaa tcaaatagag aataaaaaaa 846061 tttgaacaat tgcattggag gaatagtgat ggaaaatctt ctccgtccaa tttaccaaga 846121 aagagcaagt caccccaata cattggctgt cattatgatt gagagaagaa acaaaacatc 846181 ttccttaaca gataactttg atgcagcttt gctggtgatt gtaaaggatg ctgatgagcc 846241 agtttttata aagcattatg aatttgatca tcaaacagct tctttgcatg tggtaacaga 846301 ttctcagatt caagaatgga ttttgcttgg aacaaataga agaatcatag attggattgt 846361 aaatggcaga gtcttgtttg accgtaatga atacgtagtt gaactgattg acaggctgaa 846421 tacatttccg tttgccgaac gtaaactgaa gatcggactc gaatacggca aattaatcag 846481 aaggtatgtt gaagggaaag ctttttttga agccaatcaa tttttagatg cctacaatgc 846541 cgttgttcat gcgctgcatc atttagcacg tattgaagta atcgacagag gattccatcc 846601 cgaaaccacg gtgtggagcc aagtgcgcca gatggagccc caagtgtaca aattatattc 846661 cgagctgatt gaaagtcatg agagcctgga aaaaagactt gaattattat tcttagcaaa 846721 tgattttctc atccattcca aagccgagat cggttcggcg catcttttcg aagtaatgaa 846781 agaaaaagac atttggcaat tcggtgagct tcttcaacat catgacctaa agcactttac 846841 ccaagatctt ggcgttatgc ttgattactt gacggaaaag ggacttatca acgtctgcca 846901 gatagaaacg aaaggacagg ctgtctatca ccgaggatat tcttttaaaa aaggtgttga 846961 ctctgattct tgaccgtgtt atattattaa acgtcgctga tgcgcttctg agaaaacaag 847021 ctcacagcgg cgggaaaata aatcaaaaaa acatttgaca aaagaaagtc aaaatgttat 847081 attaataaag tcgcttcaac aagaagtgaa aatgatcttt gaaaactaaa caagacaaaa 847141 cgtacctgtt aattcagttt ttaaaaaatc gcacagcgat gtgcgtagtc agtcaaacta 847201 gggcctgcac gacgcaggtc acacaggtgt cgccgcagga tgcggtgaac ttaacctgtg 847261 atccatttat cggagagttt gatcctggct caggacgaac gctggcggcg tgcctaatac 847321 atgcaagtcg agcggacaga tgggagcttg ctccctgatg ttagcggcgg acgggtgagt 847381 aacacgtggg taacctgcct gtaagactgg gataactccg ggaaaccggg gctaataccg 847441 gatggttgtt tgaaccgcat ggttcaaaca taaaaggtgg cttcggctac cacttacaga 847501 tggacccgcg gcgcattagc tagttggtga ggtaacggct caccaaggca acgatgcgta 847561 gccgacctga gagggtgatc ggccacactg ggactgagac acggcccaga ctcctacggg 847621 aggcagcagt agggaatctt ccgcaatgga cgaaagtctg acggagcaac gccgcgtgag 847681 tgatgaaggt tttcggatcg taaagctctg ttgttaggga agaacaagta ccgttcgaat 847741 agggcggtac cttgacggta cctaaccaga aagccacggc taactacgtg ccagcagccg 847801 cggtaatacg taggtggcaa gcgttgtccg gaattattgg gcgtaaaggg ctcgcaggcg 847861 gtttcttaag tctgatgtga aagcccccgg ctcaaccggg gagggtcatt ggaaactggg 847921 gaacttgagt gcagaagagg agagtggaat tccacgtgta gcggtgaaat gcgtagagat 847981 gtggaggaac accagtggcg aaggcgactc tctggtctgt aactgacgct gaggagcgaa 848041 agcgtgggga gcgaacagga ttagataccc tggtagtcca cgccgtaaac gatgagtgct 848101 aagtgttagg gggtttccgc cccttagtgc tgcagctaac gcattaagca ctccgcctgg 848161 ggagtacggt cgcaagactg aaactcaaag gaattgacgg gggcccgcac aagcggtgga 848221 gcatgtggtt taattcgaag caacgcgaag aaccttacca ggtcttgaca tcctctgaca 848281 atcctagaga taggacgtcc ccttcggggg cagagtgaca ggtggtgcat ggttgtcgtc 848341 agctcgtgtc gtgagatgtt gggttaagtc ccgcaacgag cgcaaccctt gatcttagtt 848401 gccagcattc agttgggcac tctaaggtga ctgccggtga caaaccggag gaaggtgggg 848461 atgacgtcaa atcatcatgc cccttatgac ctgggctaca cacgtgctac aatggacaga 848521 acaaagggca gcgaaaccgc gaggttaagc caatcccaca aatctgttct cagttcggat 848581 cgcagtctgc aactcgactg cgtgaagctg gaatcgctag taatcgcgga tcagcatgcc 848641 gcggtgaata cgttcccggg ccttgtacac accgcccgtc acaccacgag agtttgtaac 848701 acccgaagtc ggtgaggtaa ccttttagga gccagccgcc gaaggtggga cagatgattg 848761 gggtgaagtc gtaacaaggt agccgtatcg gaaggtgcgg ctggatcacc tcctttctaa 848821 ggatattata cggaatataa gaccttgggt cttataaaca gaacgttccc tgtcttgttt 848881 agttttgaag gatcattcct tcgaaacgtg ttctttgaaa actagataac agtagacatc 848941 acattcaatt agtaatacaa gatatcacat agtgattctt tttaacggtt aagttagaaa 849001 gggcgcacgg tggatgcctt ggcactagga gccgatgaag gacgggacga acaccgatat 849061 gcttcgggga gctgtaagca agctttgatc cggagatttc cgaatgggga aacccaccac 849121 tcgtaatgga gtggtatcca tatctgaatt cataggatat gagaaggcag acccggggaa 849181 ctgaaacatc taagtacccg gaggaagaga aagcaaatgc gattccctga gtagcggcga 849241 gcgaaacggg attagcccaa accaagaggc ttgcctcttg gggttgtagg acactctgta 849301 cggagttaca aaagaacgag gtagatgaag aggtctggaa aggcccgcca taggaggtaa 849361 cagccctgta gtcaaaactt cgttctctcc tgagtggatc ctgagtacgg cggaacacgt 849421 gaaattccgt cggaatccgg gaggaccatc tcccaaggct aaatactccc tagtgaccga 849481 tagtgaacca gtaccgtgag ggaaaggtga aaagcacccc ggaaggggag tgaaagagat 849541 cctgaaaccg tgtgcctaca agtagtcaga gcccgttaac gggtgatggc gtgccttttg 849601 tagaatgaac cggcgagtta cgatcccgtg caaggttaag cagaagatgc ggagccgcag 849661 cgaaagcgag tctgaatagg gcgcatgagt acgtggtcgt agacccgaaa ccaggtgatc 849721 tacccatgtc cagggtgaag ttcaggtaac actgaatgga ggcccgaacc cacgcacgtt 849781 gaaaagtgcg gggatgaggt gtgggtaggg gtgaaatgcc aatcgaacct ggagatagct 849841 ggttctctcc gaaatagctt tagggctagc ctcaaggtaa gagtcttgga ggtagagcac 849901 tgattggact aggggcccct accgggttac cgaattcagt caaactccga atgccaatga 849961 cttatccttg ggagtcagac tgcgagtgat aagatccgta gtcgaaaggg aaacagccca 850021 gaccgccagc taaggtccca aagtatacgt taagtggaaa aggatgtgga gttgcttaga 850081 caaccaggat gttggcttag aagcagccac catttaaaga gtgcgtaata gctcactggt 850141 cgagtgactc tgcgccgaaa atgtaccggg gctaaacgta tcaccgaagc tgcggactgt 850201 tcttcgaaca gtggtaggag agcgttctaa gggctgtgaa gccagaccgg aaggactggt 850261 ggagcgctta gaagtgagaa tgccggtatg agtagcgaaa gaggggtgag aatcccctcc 850321 accgaatgcc taaggtttcc tgaggaaggc tcgtccgctc agggttagtc gggacctaag 850381 ccgaggccga aaggcgtagg cgatggacaa caggttgata ttcctgtacc acctcctcac 850441 catttgagca atggggggac gcaggaggat agggtaagcg cggtattgga tatccgcgtc 850501 caagcagtta ggctgggaaa taggcaaatc cgtttcccat aaggctgagc tgtgatggcg 850561 agcgaaatat agtagcgaag ttcctgattc cacactgcca agaaaagcct ctagcgaggt 850621 gagaggtgcc cgtaccgcaa accgacacag gtaggcgagg agagaatcct aaggtgatcg 850681 agagaactct cgttaaggaa ctcggcaaaa tgaccccgta acttcgggag aaggggtgct 850741 ctgttagggt gcaagcccga gagagccgca gtgaataggc ccaggcgact gtttagcaaa 850801 aacacaggtc tctgcgaagc cgtaaggcga agtatagggg ctgacgcctg cccggtgctg 850861 gaaggttaag aggagcgctt agcgtaagcg aaggtgcgaa ttgaagcccc agtaaacggc 850921 ggccgtaact ataacggtcc taaggtagcg aaattccttg tcgggtaagt tccgacccgc 850981 acgaaaggcg caacgatctg ggcactgtct caacgagaga ctcggtgaaa ttatagtacc 851041 tgtgaagatg caggttaccc gcgacaggac ggaaagaccc cgtggagctt tactgcagcc 851101 tgatattgaa tgttggtaca gcttgtacag gataggtagg agccttggaa accggagcgc 851161 cagcttcggt ggaggcatcg gtgggatact accctggctg tattgacctt ctaacccgcc 851221 gcccttatcg ggcggggaga cagtgtcagg tgggcagttt gactggggcg gtcgcctcct 851281 aaaaggtaac ggaggcgccc aaaggttccc tcagaatggt tggaaatcat tcgcagagtg 851341 taaaggcaca agggagcttg actgcgagac ctacaagtcg agcagggacg aaagtcgggc 851401 ttagtgatcc ggtggttccg catggaaggg ccatcgctca acggataaaa gctaccccgg 851461 ggataacagg cttatctccc ccaagagtcc acatcgacgg ggaggtttgg cacctcgatg 851521 tcggctcatc gcatcctggg gctgtagtcg gtcccaaggg ttgggctgtt cgcccattaa 851581 agcggtacgc gagctgggtt cagaacgtcg tgagacagtt cggtccctat ccgtcgcggg 851641 cgcaggaaat ttgagaggag ctgtccttag tacgagagga ccgggatgga cgcaccgctg 851701 gtgtaccagt tgttctgcca agggcatcgc tgggtagcta tgtgcggacg ggataagtgc 851761 tgaaagcatc taagcatgaa gcccccctca agatgagatt tcccattccg caaggaagta 851821 agatccctga aagatgatca ggttgatagg tctgaggtgg aagtgtggcg acacatggag 851881 ctgacagata ctaatcgatc gagggcttaa ccatattttt gaatgatgtc acacctgtta 851941 tctagttttg agagaataag tttttcaaaa aaacacttga ttttctcaag aatacatagt 852001 ataatgttaa atgtcactga aattgtctgg tgatgatggc gaagaggtca cacccgttcc 852061 catgccgaac acggaagtta agctcttcag cgccgatggt agtcgggggt ttccccctgt 852121 gagagtagga catcgccagg cagacttcat tccgcagtag ctcagtggta gagctatcgg 852181 ctgttaaccg atcggtcgta ggttcgaatc ctacctgcgg agccattatt ggagagctgt 852241 ccgagtggtc gaaggagcac gattggaaat cgtgtaggcg gtcaactccg tctcaagggt 852301 tcgaatccct tgctctccgc cactgatact tatacataat tacaattgaa agtctgggcc 852361 cgttggtcaa gcggttaaga caccgccctt tcacggcggt aacacgggtt cgaatcccgt 852421 acgggtcatt atatgatgga ggattagctc agctgggaga gcatctgcct tacaagcaga 852481 gggtcggcgg ttcgagcccg tcatcctcca ccattatatc atcgcggggt ggagcagttc 852541 ggtagctcgt cgggctcata acccgaaggt cgcaggttca aatcctgccc ccgcaaccaa 852601 attttaaaat ggtccggtag ttcagttggt tagaatgcct gcctgtcacg caggaggtcg 852661 cgggttcgag tcccgtccgg accgccattt gaatacttag gctcggtagc tcagttggta 852721 gagcaacgga ctgaaaatcc gtgtgtcggc ggttcgattc cgtcccgagc caccacctat 852781 gccggtgtag ctcaattggt agagcaactg acttgtaatc agtaggttgg gggttcaagt 852841 cctcttgccg gcactgtttt ttcaaaattt aatgtggagg ggtagcgaag tggctaaacg 852901 cggcggactg taaatccgct ccctcagggt tcggcagttc gaatctgccc ccctccacca 852961 tttatagggg catagtttaa cggtagaaca gaggtctcca aaacctccgg tgtgggttcg 853021 attcctactg cccctgccaa atttatgaca tcttgagatt atggcggttg tggcgaagtg 853081 gttaacgcac cagattgtgg ctctggcact cgtgggttcg attcccatca atcgccccat 853141 attatcattg ggctatagcc aagcggtaag gcaacggact ttgactccgt catgcgttgg 853201 ttcgaatcca gctagcccag tctcactttt tatatcaact gcatataatg tattaagtcc 853261 attaaaaatg cggaagtagt tcagtggtag aacaccacct tgccaaggtg ggggtcgcgg 853321 gttcgaatcc cgtcttccgc tccaattacg gcggcatagc caagtggtaa ggcagaggtc 853381 tgcaaaacct ttatccccgg ttcgaatccg ggtgtcgcct tcttattgcc ggggtggtgg 853441 aattggcaga cacacaggac ttaaaatcct gcggtaggtg actaccgtgc cggttcaagt 853501 ccggccctcg gcaccaattt tacttacatg gtaagttgaa ttggtgtttg tgttttatca 853561 ttataactaa tcatattaat gatctacata agtagatcat ttttttaatg ctttgattta 853621 tcataacaag ttaagttccg aggcctatta taaagcggct gtatagctag tctttcaaca 853681 cttttatttt atatttccat aaaaactttt ttgaaatacg ttgacacttt atgagatcca 853741 tgatatattt atattcgtcg gttagatacg acgtaaaact tgccggtgtg gcggaattgg 853801 cagacgcgca cgactcaaaa tcgtgttcct tctggagtgt cggttcgacc ccgaccaccg 853861 gtatactgaa aaacccgttt cttaacagaa acgggttttt attttttatt aaagaaaagg 853921 agcctcggct cctttttata cttactcagc gtattggtct aggatctctt ctagcacctc 853981 ttctagctct tctgtatctt caagctctga ttggctgaaa cggacgcgta caagctgttc 854041 tccgtcatta tacatctctt ccaaccaccc tcggagtcct cttgctctgc ggtcgacttc 854101 gaaaatgatt tccaaaccgt cttcgtctaa aaggaaaatg agctctaatt catcaagcat 854161 ctgacgataa tatccggaag tcggaacgaa ttcgaattct tgaacgaacg gaagacgacg 854221 ctggaagtag ggcgcttgtt cgcagtctgc ttcgttaaga cggaagccca ggttttcgat 854281 tgcttcaagc acattttcaa tccaagggtg cgcttcaacg aaaatgcggt catgatcgga 854341 tttatcgata ccgccttgaa tgtcaaggtc tgtcaccacg gcaacctcta ctttccctac 854401 agtgatcggc gtatctagag gcagagtgaa tgtgaacgga aattgatgct cttcaccagg 854461 ctgtatggta aatgaaccag tgacccggaa agaatgaatt gtagcgtatt tccggtgctc 854521 ttcatcgtct tttacaatga cataccgtgt gctaagctgt aaatcgatat aacggatgtc 854581 ctgagcgatt tttccgcctt tgacatgtac cgttccctgt acttcttctc ctggaaaata 854641 tgcgtctttt tctaaaattg tatctacttt tgcagctcca attccggcac ttgccgcaag 854701 cttcttaaaa aatgacatgt tagatcttcc cctttttctt ttttctcaac agatatacgt 854761 aagaaggagg aaaaaagatt cgtttgattc atactttttt cctattattc gtctcggcct 854821 agggacagac taagaataat attgaaaata aaggagtcga tggaagtgaa taaagaaagt 854881 ttggttgcag atgaattaca cagaatgttt ttggctggtg agctgcaaat cacagtagag 854941 gaggatataa acaatatttc cgaaaggctg agaaacggcg atctcagttt agaccgatta 855001 agcggtgaag acgtgtttat aaaagaaacg gtaaatgagg ctttaagaag agtggagcaa 855061 taaaaaagag acggcatctc atctttgaga tcccgtctct ttttgtggtc tttgctgtaa 855121 gataaaagcg aatcgatttg gaattgctca cccgagccac cccttttcta acagaagatc 855181 tgacagttca tcatggagat aaacagctgt atctaattga tcatgcaatg ctcttctgat 855241 gtggggattt tcggttgctg ttgttgcgac agtgtatttg ttaatgctgg tttttattgt 855301 tgttaacaaa tcaagaatat ctttgggaca aagactttgt tcaatgggaa accacctcct 855361 ttgttttttt agcagctcct gataagaaag tatttgactt tgtttcttgc ttctatacaa 855421 aatgctataa taagcaacaa attttgttgg ggggtgtgat gatgaagcag attattgcga 855481 tggggggcgg gggtttttcg atggagccgg ataatttgtc cctcgatcaa tatatcctca 855541 atcaatcaaa acgagagcag cctcgtattt gttttttgcc gacggcgagc ggagattccc 855601 aaaactatat tcagcggttt tatcatgcat ttcaaacatt ggattgcgtg ccgtctcatt 855661 tatctttgtt taagccacca tcatcagatt tagtttcttt tgttatggaa atggacgtga 855721 tttatgttgg cgggggaaat acgcggaatt tacttgtgtt atggaaagag tgggggctgg 855781 accatattct cagggaagca tggaagaacg gtgtggttgt agctggaata agtgccggtg 855841 cgatctgctg gtttgaagaa ggggtgacag attcagccgg accgctgaca agtttgaaaa 855901 gtttaggttt tttgcaaggg agcttttgtc cccattatga cggggaaaag gatcggagac 855961 cggcatacca ccagctgata tctaacaagt tcttatgcag tggctatgca gcggatgatg 856021 gggctgctct ccatttcata aatgatcagc tgtttcagac tgtgagttca aggtcgggtg 856081 caaaggcata tcgggtgatg atggctgaac atgaaatagc tgaaatcccg ttgccggtca 856141 aatatttagg gtgaaattgg ctgaatatta tctatattcc tctttttttc agattgattt 856201 tatgataaga tgagtgcgaa atcaatagtt actgggggtg cccgctttcg ggctgagaga 856261 gaaggcaagc ttcttaaccc tttggacctg atctggttcg taccagcgtg gggaagtaga 856321 ggaattgttt ttgttattgt cttgctgggc aataatatgt ttctttctga ctgtaaccgg 856381 gttcatttat atgaatccgg ttttttgtgc tggttatggg cttgattttg tcctttcaaa 856441 cgtagaaagg ggaaggaaaa gtaatgcaaa acaattcagt gcagcaagcc aacatttcca 856501 ttatgtcaag tttttcaggc agcaagaagg tatacgtgga gggttcttct tcggacatcc 856561 aagtgccgat gagggagatt gcattgagtc cgacgacggg atcgttcggc gaagaggaaa 856621 acgcgcctgt gcgtgtctat gatacaagcg gaccgtatac ggaccctgaa gtaaccatta 856681 atattcaaga aggattaaag ccgctccgcc aaaaatggat cacagagcgc ggtgacgtgg 856741 aagagtatga aggtcgggct ataaaaccag aagataacgg ttataaaaaa gcaaaaccaa 856801 acgtaagcta tccaggatta aagcggaaac cgctgagggc gaaggcaggt caaaatgtca 856861 cacaaatgca ctatgcaaaa aaggggatca ttacacctga gatggaattt atcgccattc 856921 gtgagcatgt gtctcctgaa ttcgtcagag acgaggtagc cagcggccgg gcgattattc 856981 cttcaaacat taatcaccct gaaagtgagc caatgattat cggccggaat tttcatgtga 857041 agattaatgc aaatatcggg aattcagcgg ttacgtcatc cattgaagaa gaagtggaaa 857101 aaatgacgtg ggccatccgc tggggagcgg atacgatgat ggatctctct accggaaaag 857161 atattcatac gacgcgtgaa tggattatcc gcaattgccc cgtgcctgtg ggaactgttc 857221 cgatttatca ggcgcttgaa aaagtaaacg gcgtagctga ggatttaacg tgggagattt 857281 atcgtgatac gctaatcgag caggcagagc agggagtgga ttattttacg attcacgcgg 857341 gtgttttgct taggtatgta ccgctgactg ccaaacggac aactggtatc gtgtcacgcg 857401 ggggagcgat tatggcgcag tggtgtctgg ctcatcatca agaaagcttt ttatacacac 857461 attttgaaga aatatgtgag attatgaaaa tgtatgatat tgctttctct cttggggatg 857521 gtttgcgtcc cggatcaatt gctgatgcca atgacgaagc gcagtttgct gaattagaga 857581 cgcttggaga gctgacgcaa attgcctgga agcatgatgt tcaggtgatg attgagggtc 857641 ctggacatgt tccgatgcat aaaatcaaag agaacgtcga taaacaaatg gacatttgta 857701 aagaagcgcc tttttacaca ttggggccgt tgacaacgga tattgctccg ggatatgacc 857761 atattacttc agcgatcgga gcggcgatga tcggttggta cgggacagca atgctttgtt 857821 atgtaacgcc gaaggagcat ttggggctgc caaaccgtga tgatgttcgt gaaggagtca 857881 ttacatataa gatcgctgcg cacgctgcgg accttgcaaa agggcatccc ggagcgcaaa 857941 tccgggatga tgcgttatcg aaagcccgtt ttgaattccg ctggcgggat cagtttaatt 858001 tatctcttga tccggagaga gcccttgaat accatgatga aaccctgcct gctgaaggag 858061 caaaaaccgc tcacttttgt tccatgtgcg gtccgaaatt ttgcagcatg agaatttcac 858121 aggatattcg ggattatgcg aagaaaaacg atctcagtga agcagaagcc ataaataaag 858181 gattaaaaga aaaagcaaaa gagtttgtcg atacgggaag caatttatat caataaaaaa 858241 aatgaagatg gagaatgctc catcttcatt tttttagaaa aacagagagc gtcgaagcgg 858301 aggaatactc tgttcaaagc ggaaaacatt ttctggatca tatgtcgttt tgacacggcg 858361 gagtcgttca acgttttcgc cgtaatatgt tcttggccag tttctgattt cgatatctgg 858421 ccaatttacg tagtctccca tcgtttcttt cgaaagggac gttctcagcc cctcaatcca 858481 gcggacattt tgtctttttt ctccagggga tgtccagttt gttaagtatt cctgggcgat 858541 gattgcgtca cgataataaa atgccgtttg gtcgggagcg acccgtccgg ctgccccgcc 858601 gagtgcttgc tgccagacac tggcgttttg attcggagcg tgctctaaaa agtgttttat 858661 tgttgagatc gcacgttctg ataatggctt ttcaatgaaa gagccggagc gtttcatttt 858721 ttgaggctga ttgcctcccg ggctgttaaa aaaggttacc gcttcaatga atggcgttgt 858781 ttttaccatt ccgcttgtcg gacttcctgc tttcaataaa ggctttaaca gtttttttaa 858841 ctctgttttt ggcccgacaa attggccgag ggcttctatg cggtttactt ctttaggcca 858901 aaactctatt gatgatgtaa gccggtcatc tgtatacggg gcccagttct gccacgtgtt 858961 atatacttcc tcaaaatcat cccatcccca tgtaatagaa aaaatcgaca cttgagagat 859021 gggcactgct ttaaatgtca tggaggtgac tatgccgaaa ttgcctcctc cgcctccctg 859081 agacgcccaa aataagtctg gatgatttga acagctgact gtaatcagat cagcgccctc 859141 tttttcgtct gctacgatca tctcaagctg cacgaggctg tcgcaagtaa gaccggcagc 859201 ccttgttaaa agtccaattc cccctccgag agttaaacct gtgagcccta cattagcaat 859261 ggtgcctgcg ggaagcgtca ggccgtattg ccagagtgtc cgatagactt ctcccaattc 859321 agcccccgct tcaatatagg ccagcttttt atcctgattc acagttattt ttttcatctc 859381 gcttaaatca ataacaagac cgttatttaa aagggaaaag ttctcatagc tgtgtctgcc 859441 gcctctaata cggaaaggca cacggttttc acgcgcccat ttcagcgcat tgagtgcatc 859501 ctgtttgttt tggcaaaaca caatgatgtc aggatacctt tctaagctta ggttaatatt 859561 ggttcttgct tcgttatagt ccggatcatc ccgtgtcacg atacgtccgg tcaattttgt 859621 cttttccaca ctcccacatc tctttctctc gtattctagt ttctctagct tatgcgtcag 859681 gggaaaagag tgtataagga aaaagcgggg atgcaatctg atacagtgtc aacaccctca 859741 aaaaatagtt gacaggtcgg tattgtatga attaacatgg tcagtacaaa tttttcaaat 859801 ttatcgcgct gatcggaaca ccgaaggctc ttatcgttta gataagggcc ttttttgtat 859861 gaaaaagggg ggattattga tgggagtcaa aaaagaaaag gggagaaaac gattcaggaa 859921 gcgaaaaacc tacgggaatc agattttgcc gcttgagctg ctgattgaaa aaaacaaacg 859981 agagattata aacagcgcgg aactcatgga agaaatttat atgaagattg atgagaagca 860041 tacgcaatgt gtaactaaat ataaaaaaac ccgctgacta caacgggttt ttgcatttct 860101 ccattaagaa tcttttttaa tcggcaatcc aaggccttct gccacgcgtt ttccgtattc 860161 aggatccgct ttgtagaagt gctcgatttg gcgcagcttg atttcttctt tttctaccgg 860221 cttcatggca ttaacgatat tttcaacaag gcgggtacgt tcatcttcac tcattaaacg 860281 atacagatcg ccggcttgag tgtagtgatc gtagtgatcg tagcttacgc tgtcagcgat 860341 accttgtacc ggatatgctg cttgcttatc ctcaggtgac tcttttggac cgccgaagct 860401 gttaggctcg taatacacag atccgccgcc gttatcatca aaacgcattt gcccatcacg 860461 ctgataattg tttactttgt tgcgtgcgcg gttgattggc agcgcttgat ggtttgcacc 860521 gacacggtag cggtgtgcat catgataagc aaaaagtcga ccttgaagca ttttatccgg 860581 tgaaacatca ataccaggca cgagggttcc aggtgaaaat gtcgcttgtt ctacctctgc 860641 aaagtagttt tccggatttc tgtctagaac catgcgtccg acctcgatta acgggtagtc 860701 tttttgagac caaacttttg tgacatcaaa cggatcgaaa cggtacgtat ttgcatcttc 860761 taaaggcatg atttgcacat atagtttcca tgcaggataa tcaccgtttt cgattgcgtt 860821 gaaaaggtct tctgtatggt aatcagggtt ttcaccggca atttttgctg ccgtattgac 860881 atcaaggttt ttcacgcctt gttctgtttt aaagtgatat ttaatccata cgccttcgcc 860941 ttcggcattt gtccatttga atgtatggct tccgaagccg tgcatgtggc gaagtgtcgc 861001 aggaattccg cggtcagaca tcaggattgt cacttggtgc agtgactctg gtgaaagtga 861061 ccagaaatcc catacagccg tagggttttt caggtgtgtt tttggatctc ttttttgtgt 861121 atggatgaaa tcagggaact taatcgcatc gcggataaag aatacaggcg tattgttgcc 861181 gacgatgtcg tagtttcctt cttcagtata aaatttaaca gcaaatccgc gcgggtcgcg 861241 aactgtgtca gcagagccaa gttcaccggc aactgttgag aaacggatga acaacggtgt 861301 gcgtttgccg acttcagaaa ggaaagcggc tttcgtgtat tttgttacgt cgtttgtcac 861361 ttcaaaatat ccgtgtgcgc ctgctccttt ggcgtgaaca acacgttcag gaacacgttc 861421 tcggttgaaa tgggccaatt tttcgagtaa atgtacatct tgaattaaag ttggtccgcg 861481 agaaccggca gtcattgagt tttgattatc tccaaccgga gcgccccagc tagttgtcag 861541 tttatttgaa ctcatgttat cacctcttgg aatttataag aacataatat catctctaag 861601 taaaaagtca atattatttt ataattatta taaaatagtt atctctatta atcgatatat 861661 agtatcgaaa ttgttgaaaa accttgttgt aacagctttt tatgacactt aataattttt 861721 ggagaaataa tttttccttc tctatttgcg aaacaagcag agtaagtgat aaacaaggat 861781 atcaaaaatc gtatttaaaa aagagttgac atatcggaat aatttgaatt aacatgttat 861841 tcaaacaaaa aaacaattgg gcagctgatc ggaccgccga aggctctcat ctctacaaga 861901 acagagatgg gggccttttt gttttttttg aaggcggggt tggcagaaag agagggataa 861961 aagtggctgt gaccatcagc atcaaagaaa aggcatttgt tcaagaaggc cgcaaaaaca 862021 cggtcttaga aaacatagaa ttatcaatcg caccaggcga atttctaacg cttatcggac 862081 cgagcgggtg cggaaaaagc accctgttaa agattattgc agggcttgat tctgaatatg 862141 acgggagtgt ggaaattaac ggccgcagcg taacagctcc gggtattcag caaggattta 862201 tttttcagga acaccgcctc tttccttggc tgactgttga gcagaatatt gcagccgact 862261 tgaatttgaa ggacccaaaa gtcaaacaaa aggtggatga actgatcgag attgtcagat 862321 tgaaaggatc ggaaaaagca tatccgcgcg agctgtcagg cggcatgtca caaagagtag 862381 ccatcgcccg ggccctgctg cgggagcctg aggtgctgct tttagatgaa ccgtttggtg 862441 cactcgacgc ttttacaaga aaacacctgc aggacgtgct gctggatata tggaggaaga 862501 aaaaaacaac gatgattctc gtgactcatg atatagatga atctgtttat ttaggaaatg 862561 agcttgcgat ccttaaggcc aaaccgggga aaatccataa gctgatgccc attcacctgg 862621 cgtatccgcg aaaccggacg actccggatt tccaagcgat cagacagaga gtgctgtcgg 862681 aattcgagaa aacagaagat ttggagtacg cagaaggatc agggatatag aaagggcgga 862741 agcggaaatg aaaaaaggac tcattgtatt ggttgccgtt atttttctgc tcgcaggctg 862801 tggagcaaat ggagccagcg gtgaccacaa acaattgaag gaaattcgta ttggtattca 862861 gcaaagctta agcccccttt tgattgcaaa agaaaaaggc tggttcgaag atgcatttga 862921 aaaagaaggc atcaaagtga aatgggtgga gtttcaaagc ggtccgcccc aatttgaagg 862981 ccttgcggca gacaaacttg atttttctca agtcggtaat tcgcctgtga tcgctggaca 863041 ggcggcaggc attgacttta aagaaatcgg tttgtctcag gacggcttga aagcaaacgg 863101 catccttgtc aatcaaaaca gcggcattca agacgttaag ggcttaaagg ggaagaaaat 863161 tgcagtcgcc aaaggcagca gcgggtttga ttttttgtat aaagcgcttg atcaagtggg 863221 gttgtcagct aacgatgtga caattattca gcttcagcct gatgaagcag cttccgcatt 863281 tgaaaacgga tctgttgatg cctggtccat ttgggagccg tacttgtcct tagaaacaat 863341 gaaacacgga gcaaaaatcc ttgtgaacgg agaaagcaca gatttatatt caccgggttt 863401 tactttagta agaacaaagt tttcagaaga gcatccagac gaagtggtcc gttttctgaa 863461 ggtgtttaat aaagccgttg tatggcaaaa ggaacatctg gatgaagcag cggacttata 863521 ttctgacatt aaagatctcg ataaaaaggt cgtcgaaaat gtgctgaaaa atactgagcc 863581 acttaatgag atcatcagtg acgacattgt gaaagcacag caggaaacag cagattttca 863641 atttcgaaca aaggcgatag ataagaagat tgatgtgaag gatgttgtcg ataacacttt 863701 tatcaaaaaa gcattagagg agcattcctc aggaggtgat caatgatgaa agcagaggct 863761 gcgggctcgc tgcccaaaac gaatgcggaa gcggtgcgaa aaaagcccgg aaggaagaga 863821 tacggctgga tgaaggggct tttactgccc gctgtcatca ttgccatctg gcaggtcatc 863881 ggcgggctgg gggttgtgtc cgctacagtg ctgcctacac ctgttacgat tgttctgacc 863941 tttaaggagc ttattttgtc cggcgaactg ttcggccatc tgcaaatcag catttatcgg 864001 gcggcacttg gttttttgct tggcgcgggg cttggattga tgatcgggat tttggccgga 864061 ttttccaaac ggacggagct gtatcttgat ccgtcgttgc aaatgcttag aaccgtacct 864121 catctggccg tcacgccgct gtttatttta tggttcggat ttgacgaagt atctaaaatt 864181 ttgctgattg cgctcggtgc cttctttcct gtctatatca atacgtttaa cggcatccgc 864241 ggggttgacg cgaagctgtt tgaagtcgcc cgggtgcttg aatttaaatg gcatcagcag 864301 atatccaaag tgatattgcc ggcagccctg cccaatatat tgctaggcat tcgcttatcg 864361 ctcggcattg catggctcgg gctcgttgtg gcagagctga tgggctcaag ctcgggagtc 864421 ggctatatga tcatggatgc gagacagttt tcacaaacga ataaagtctt tgcagggatt 864481 atcatttttg cagtggttgg aaagctgacg gattccttcg tcaggctgct tgaacgaaag 864541 ctgttaaagt ggagaaacag ctacgaagga taaaagatat aaaggggaga tgaatatgga 864601 aattctttgg tttataccga ctcatggaga cgcgagatat ttaggatctg aaagtgatgg 864661 acggactgcg gatcatcttt actttaaaca agtcgcgcag gcggcagaca ggctgggata 864721 tacaggagtt cttctgccaa cgggaagatc gtgcgaggac ccgtggctta cagcgtcggc 864781 actggcagga gaaacaaagg acttaaagtt tttagtcgcg gtaagacctg gtttaatgca 864841 gccttctctg gcagccagaa tgacatccac cctagaccgc atttcagacg gccggctgct 864901 gatcaacgtt gtggcagggg gcgatccgta tgagctggca ggcgatggcc tgtttatcag 864961 ccatgatgag cgctacgagg caacagacga atttttaacc gtttggcgga gacttttgca 865021 gggagaaacg gtttcctatg aaggaaagca tataaaagtg gaaaacagca atctgctttt 865081 cccgccgcag caagagccgc atccgcccat ctatttcggt ggttcgtcac aggctggaat 865141 tgaagctgcc gcaaagcata cagacgtgta cttgacatgg ggtgagccgc ctgaacaagt 865201 aaaagaaaag atagaaagag tcaaaaagca agcggcaaaa gaagggagat ccgttcgatt 865261 tggcattagg ctgcatgtca ttgcccgtga aactgaacaa gaggcatggg aagcggcaga 865321 gcgcttgatc agccacttgg atgatgacac cattgccaaa gcgcaggcag ctttgagccg 865381 ttacgactct tcaggccagc agcggatggc cgtccttcat caaggcgatc ggacgaagct 865441 tgaaatcagc ccgaatctgt gggcggggat cggcctggtc agaggagggg caggaacagc 865501 tcttgtcggt gatccgcaga cgattgccga ccggatagcg gagtaccagg cactcggcat 865561 agaatcgttt atattctccg gctatccgca tttagaagaa gcgtattatt ttgcagagct 865621 tgtatttccg cttttgccgt ttgaaaatga tcggacgaga aagcttcaga acaaaagggg 865681 agaagcggta ggaaacactt attttgtcaa agagaaaaat gcatgagttt aactaaaata 865741 cagccccccg aacatggtat gatattcaaa aaaagggggc tttttttctg aaaacattga 865801 gaagcgcggc agtcatttgc ctcatagcta tgctgtcagc atgcggacat tcaaaacaga 865861 tggaaatcaa agcggcggac atatcagatc ttgaaaaaaa cagaatggat gtcgcagctt 865921 cacaggcatt cactgccgaa gccgtcaata tcggtgaagg tatttcttca gctgacatgt 865981 acatcgaaca ttatcaaaag ggaaagcttg ttgagaggtt tggaccggtt cgtgcagatt 866041 attcagagga aaaaactgat accatacaat ttgtttattt tgagaatgaa gagggggaag 866101 gaaagaataa acataccacc attcattttg gcattgtgga taaacaggga actatagcgg 866161 ctgattcatc ggtgaaacgc gacgatagca caacacagga aatgactcag aatatttcat 866221 cgccggaacc gattactttc gagaagcctg ctttgatcgg cagcagtatt agagggactg 866281 acgagacaat gcacacctct gaacataaaa aagagctcat taagcatcaa gatgcgttac 866341 tgtattatgt ggaattgcat cattagaatg ggcggcttca ggccgtctgt tttacaaagc 866401 ggtatgcttg cttttttgaa tggtgaatga tacattttaa atcgtaacaa tttcgattta 866461 aagggaggct atgtgacttg gctaaaaaat caaaagtggc aaaagagtta aaacgccaac 866521 agcttgttga gcaatacgct ggtattagac gcgagttgaa ggaaaaagga gattacgagg 866581 cactcagcaa gctgccaaga gattcagcac cgggaaggct tcacaaccgc tgcatggtaa 866641 cggggcgccc gagagcatat atgaggaagt ttaaaatgtc cagaatcgct ttcagggagc 866701 tggcccataa aggccagatt cccggtgtga aaaaagcaag ctggtaagaa aaaactccgg 866761 ccgattacag cgcgccggag tttttttcgt ttttcttgaa agagatgacg taggaaaggt 866821 gctggatgat catgatgata aacacaataa taatagggaa aaacggaatg cgcgattgaa 866881 atagcggata aaaaatgaga agaaccgctg cggcaggcag cgagaagtag acagcgatat 866941 atgacgcgcg acatgctttt gccgtcatca tctgctctct ttcatcctgc tcttcaaact 867001 catcaggcag aagtagctgc tttctggcag ggcggctttt tttctgtaag tacaaataaa 867061 ccgcagacgc cgcaacaaac agaataaagg gagtgaggtt taaatcaaat accatcccgc 867121 cgctctttgt gccgaaaaaa gatgctatgc cttctgaggc ttcaaagtat gaaatcagcg 867181 cccagcatgc aaggccaaat aaaacaaggt gaaaagctgc ttttgttttc atgctcatct 867241 tagttttcct cctctaacca aaagacatcc tccattttca tggagaaggc tttgcagatt 867301 ttcagtgcta acagcagtga gggaacataa tcgccttttt caatcgctgc cacagtctgt 867361 cttgtgacgc cgaccgtttc tccgagtttt tcctgagaat agccgaagcg tgccctcagc 867421 tcttttactt tatttttcat catgacgtct gtccccttca caatctcgat tgattatatt 867481 gtatagtata cttaacatta tgtaaatgga acttaacaac tttacaaaaa gataactttt 867541 tttcgacaaa atttttatat tcccttgacg aaaaataaat aaacatgtaa tataaaaaaa 867601 gtcagagcgg tactgttgct gacaatcaca aatgcgggtg tagtttagtg gtaaaacctc 867661 agccttccaa gctgatgtcg tgagttcgat tctcatcacc cgctccatac atacgttatt 867721 aacgcagtgt ttcgtttctc agataaacga agtattgcgt ttttttatgt gaaaaagaac 867781 acggtattcg tgttctttta cgtaagccaa tgtactgtat gggtgccgcc gtgaatttgt 867841 tcaaacattt tcgttaatga tgataagagg ttaacagcgc tgcttttctc aatcgatggc 867901 gggaaaaaaa tgatttgcag catattctta gtctcgtttg aaacgggata gtggttgacg 867961 ctgtttttga aatcgccaaa aatgccgttt tcatcagaga aaagcagtat gttttctttt 868021 tctcccaatg agatccggac cggctcatga agctttccgg catcataaat cataataggc 868081 agagaatatt ttaatgcgaa aaaatcgatt gtgtcatggg ccgagtcttt actttccatg 868141 aattgttcct tggatatcgg gaccagcatg tcctccattg gggttgtttc tccctcaaat 868201 gaagggttaa gctgtttaaa gagtttctgc cattccttga cgaaggattc atcggatata 868261 ccgccgtccg catagtcgaa aaacaaggat tcttgaaaca ggcggagtct gcctttcagc 868321 atttgcggtg aggagccgac ttcgatattc tcataaatga cagcagctgc atgtaagccg 868381 gccgcacgtt cagtaataac agaatcaagt ttgatattca ctagcattca ctccagttac 868441 gtgatatcaa cctattataa acgctgtgtc gttttatcac aaagaaagga ggctgtgcaa 868501 aacatgaacg tttatcagct caaagaagaa ttaattgaat acgcgaaaag cattggcgta 868561 gacaagattg gttttacgac cgctgatact tttgacagtt taaaagaccg tttgattctt 868621 caagaatcac tcggctatct ctccggcttt gaagagccag atatcgaaaa aagggtgacg 868681 ccgaagcttc ttttgccgaa agcgaaatca atagtggcaa ttgctctcgc atatccttcc 868741 agaatgaagg atgcgccgag aagcacgaga actgagcgca ggggcatttt ttgcagagct 868801 tcctggggaa aagactatca tgatgtgctg agggaaaagc ttgatctgct ggaggatttt 868861 ctaaaaagca agcatgagga tatcagaacg aagtcaatgg ttgatacagg tgaattgtct 868921 gatcgcgccg ttgcggaacg tgccggaatc ggattcagtg cgaaaaactg tatgatcaca 868981 acacccgagt atggctctta tgtgtatttg gcggaaatga tcacaaatat cccttttgag 869041 cctgatgtgc cgattgaaga tatgtgcggg tcctgcacga aatgcttgga cgcctgccca 869101 acgggagcac tggttaatcc cgggcagctt aatgcgcagc gctgcatctc ttttctgacc 869161 cagacaaaag gatttttgcc tgatgaattc cggacaaaaa tcggaaaccg cctgtacggg 869221 tgcgatacgt gccaaacggt atgccctctc aataaaggga aggattttca tcttcatccg 869281 gaaatggagc ctgatcctga gattgccaaa ccgttattga agccgctttt ggccatcagc 869341 aatcgggaat ttaaggagaa attcgggcat gtctcaggtt cttggcgcgg aaaaaaaccg 869401 attcagcgaa acgccattct cgcgcttgcc cattttaagg atgcttccgc actgcctgaa 869461 ttgacggaac tgatgcacaa ggatccgcgt cctgtcatca gggggacagc cgcatgggca 869521 atcggaaaaa tcggagaccc cgcctacgcg gaagagcttg aaaaagcgct ggaaaaagag 869581 aaggatgaag aggcaaagct ggaaattgaa aaaggaattg agttgctaaa agcttcaggc 869641 atgactaaac aaggcctgtc ctgacatacg tatagagcag aaggaaaaaa cacttgagat 869701 catccaagtg ttttttctct ataaaaaagt atggcgggtg gggtgagctt gaagtacatt 869761 ttagaacaat tagcggagga gcggctgggc tttctggtta acgggcatgc tatgagacag 869821 gagtctcaag tcggagacct taaagtcatg gagcgtaaga aaaagcttct ggaaaaacgt 869881 aaagttgaca tcataaaagc gaaagcaaag gccgtgatta atcatgtgcg ggttgaggat 869941 gacggaacga cctgcctttc gtataccatc cattacgaat acgtgtgtaa ggaacaagat 870001 gacagcttgt atatagaaga gcacatagag gagcgaatgg ctttcctgta tgatcacatt 870061 ttgattagtg atcaggaaat tgcgaaaaag ccggctggat ttcatgaagg gaccagtatt 870121 attgactatt ctgaagctga agaggaaaga gaagcgtttg gcagggcttt tcaatacgat 870181 cgtctcggcg ctgtccaata tgccgagaaa ttttggaaca agcgcaatcc tgcttataaa 870241 aatttcagcg ataactgtac aaattttatt tctcagtgtc ttcatgcagg aggcgcgccg 870301 atgcgcggtc atccgaacag gggatcaggc tggtggatga aacaaagctc atggagctac 870361 agctggacgg tggctcactc tatgaaaatg tatttgtcga attcaaaggc cggactgcgt 870421 gcggtgcggg tgaaatcagc ggaagaactg atgccgggcg atgtgatttg ctatgacttc 870481 gaaggagacg gccggtttaa tcatacaacg attgtcgtgg caaaggacaa aggcaatatg 870541 ccgcttgtca acgcccagac ttatgacagc aggatgaggt attggtcata tgaggattct 870601 acggcataca cgccgtcaat acgatatgcc ttttttcata tcgttgatga tacgacaaaa 870661 gagtaattaa tgttataatg atgggcggat aagaaaaaca gaggtgaaca ttgtggcatt 870721 acatgtcgtt ttatatcaac cagaaattcc cgctaacaca gggaatattg cacgtacttg 870781 tgcagcaacc aatacaacgc tacacctgat tcgtccgctc ggcttttcaa cggatgataa 870841 aatgctgaag cgtgccggac tcgattattg ggagtttgtt aacgttgtgt atcatgattc 870901 gttagaagaa ttgtttgagg catataaaaa aggcaagttt ttctttatta caaaatttgg 870961 ccagcagcct catacatcat ttgattacac tgatcttgac gaggattatt tcttcgtgtt 871021 cggaagagaa acaagcggtt tgccaaagga tttaattcaa aataatatgg accgctgcct 871081 gcgtcttccg atgacagagc atgtcagatc gttaaatctg tccaatactg ccgcgattct 871141 tgtttatgaa gcgctgcgcc agcaaaatta ccgtgattta aaatagtgaa aaacccgctc 871201 atcgatgatg ggcgggtttt tttgcggatg ttgaaatgct ttgtttcgtt tttgggctta 871261 acaacgtaac agtgttatgt tacaatgtac ccatcaaagg agctggactt atggaagaac 871321 aattaatctc taaaaaagaa ttacttgaaa gaacatcgat ttcatacggt cagctgtatc 871381 gatggaagcg gaaaaactta atacctgagg aatggtttat tcgtaaatcc acatttacag 871441 ggcaagagac gttttttccg agagaggaga ttttaaaacg tatatcaatg attcaaaaga 871501 tgaaagaaaa tttgtctttg gatgaaatga gggaaatgct gtcgccgaaa atgaaggatg 871561 tcagcatgac cgctgatgaa ttgcttcata aaggtttggt ttcaaggcct gctcttgaag 871621 cctattcaga agacggagga agtccggttt tttcatccag cgatttgctt tcgctgtttg 871681 tgcttgaggg cctgctgcag tctggaaatg tcagccttgc agaagcaaaa atggctgcag 871741 aggtattaaa gaagcatgat actgaagaga ttgaaaaaca gacggagctg attgtgctcc 871801 gcaagctcgg tgtcacaact tgttttatag cggctgcggc ggacagcatt ttgtttgaat 871861 catccgtaaa ggttgtggaa cgggtagatt tattaaaagc ttcagaggaa ttaaaaacaa 871921 catttatgca ggagggccat caatggatgt agtggaaaag ctggtgataa atggatcagg 871981 aagttctaag ggaggaacat ttcaatcagt tgagattaat ggcagcggga cagtggccgg 872041 ggacgtggag tgtgacactt tttcttttaa tggaaacgga aaagcggacg gcagcgtcaa 872101 agcgaaagcg gtaactatca gcggttcagg aaagatacat ggagacgttg aagcagaatc 872161 tatccggatg aatggcactg gttttattca aggagaggta tctgcaaaac aattgaaaat 872221 cgctggatca tcaacatttg gcggcactgt caaggctgat ggaattgaca ttagcggaaa 872281 agctgtcatg gaagcagatt gtgaaacaga aacctttcaa tcagaaggga aatgcaaaat 872341 cagcgggctt ttaaatgcag accaggtgat cattaagctt tctgcagggg aaagctatgc 872401 gcgggagatc ggctgccgcc atcttcaagt gacctgcaga aaaggaatgc tgacattgct 872461 cagattgatg ccgcagcctg ttctaacagc agagctgatc gaaggtgacg tgattgaatt 872521 gacaaataca aaggcgaaaa ccgtgcgcgg taataaagtg atcatcggcc cggattgcca 872581 gattgaaacc gtcgaataca gcggggacta tacctgtgat ccaagcgcgt cggttgaaac 872641 atccacaaag ttgtaaggag gatcgtaatg gagacaacaa aactgggaaa tttaaaatta 872701 tatggcgctg ggcatgccgc aggaggcgcg tatcacaatg tcagcatcaa aggagaaggt 872761 atagttggag aagggctgtc tgctgtaggc tgccgcatat acggaacggg cctttttctc 872821 ggaaaagcag agactgagcg gctgcgtgtg ctcggagaaa gtgaatgtaa aggcgatctg 872881 acagccggca aaatcaatat atatgggaca atgaaagtca gcggctcact tcaatttgat 872941 cgattcaatc tgaaaggcca gactgaaatt ggcgggaata tgactggaga atcctgcgat 873001 gtgaaaggga agcttagcgt aataggtgat tgtgaaacag aaatgttcca tgtcacaggc 873061 tgtgttgatg tatcggggtt attaaattcg ggtgagatca agctgggatt gagccatgat 873121 ataagccatg tgcaggaaat cggcggaaca acaattacag tgaaaagacg cgcgagtttt 873181 tttagccgga agaaagggaa gctgatcgcc gatgtcatag aaggagatcg ggtttatttg 873241 gagaataccg aagcggcagt tgtcagggga aaagaagtga tcatcgggcc gggatgcagc 873301 atcggaacga ttgagtacga atacaaatgt gaatgcgatc cgcattcaca gattaaagaa 873361 aaaacaaaac tgtaaaacat tgttctgtta tacaaaaagg gtgctctttc aggagcaccc 873421 ttttttattc ttttccaggc ttgctttcgt atcctgcggt aaaaattgat actaaaaaag 873481 tgacaatgac acccatcatg atgattgttt tcaccgtctc tccccctctt caatttttcc 873541 gtgctgtccg agtctggatg attctgtatt tttctttatt atgaacggtc gcagtctgcc 873601 ttgtcaacga tgtatgagta tctttatttt taagaaacca aagcatgtat cacgagatgg 873661 cggcatagat tgtatcaaag taccttattt gcatagtgta tcaaacatga tagaggaggt 873721 ccttatggat atattaaaga aaattgaaaa gtacagagag gaagagcagc ggctgaaatg 873781 ggaaggaact ttcgccgatt atttggagat tattaaagaa aatccgatgg tcgcgcaatc 873841 tgctcattct cgagttttta atatgataaa agacagcggg atagaggaga ttgacggacg 873901 caagaagtac agtttttttg accgcgagct gttcgggctt gaagaatctc tggagcgtct 873961 tgtggaagag tattttcatc cggctgccaa acgtctagat gtcagaaagc ggattctatt 874021 gctgatgggg cctgtgagcg gcggtaaatc cacgctggtc acaatgctta aaaaaggtct 874081 cgaagcgtac acgctgacag ataatggcgc tgtatatgcg attaaaggct gcccgatgca 874141 cgaggaccct ctacatttaa tcccccatca tttacgcgat gacttttaca gagaatacgg 874201 cattagaata gaaggaagtc tttctccttt aaatgtcatg aggctggagg aagagtacgg 874261 aggaagaatt gaggatgtga aggtggagcg catcttcttt tcagaagata agcgtacggg 874321 aattggaaca ttcagtccct ctgatccgaa atctcaggat attgccgatt tgacggggag 874381 tattgatttc tcaacaatcg ccgagtacgg ttcagaatca gatccgcgcg cttatcgatt 874441 tgacggagag ctgaataaag cgaaccgcgg gatgatggag tttcaggaga tgctgaaatg 874501 tgatgagaaa tttctctggc atttgctttc cttgacacag gaagggaatt ttaaagctgg 874561 gcggtttgcg ttaatttctg ctgatgagct gatcgtggct cacacgaatg aaacggagta 874621 tcgctcattt atttctaata agaagaatga agccctgcac tcaagaatca tcgtgatgcc 874681 ggttccttat aatttaaaag tgtctgagga agagagaatt tatgaaaaaa tgattgcaga 874741 aagcgatgtg gcggatgttc atattgcccc gcatacgttg aaggtcgccg cgatgttctc 874801 aatccttacc cggttaaaag agccgaagcg gtcggatatt gatctggtca agaaaatgag 874861 actgtatgat ggggaaagtg tggaaggata taactctgtc gacgttgagg atatgaaaaa 874921 agaatataat gatgaaggca tgagcggaat tgatccgcgg tacgtgatca accggatttc 874981 ttcaacgatt atcagaaaaa atatggaatc gattaattct ctcgatgtcc ttcgctcctt 875041 aaaagaaggt cttgatcagc acccatcaat ttcaagcgag gacagggagc ggtatttgaa 875101 ttttatctct gccgcccgca aggaatatga cgatattgcg aaaaaggaag ttcaaaaagc 875161 gtttgtttat tcatatgaag aatcagcaaa aacacttatg gacaattacc tcgataacgt 875221 agaggcctat tgcaataaaa acaagcttcg tgatcctttg acaggagagg aaatgaaccc 875281 tgacgaaaag ctgatgagat ccatcgaaga gcagatcggc atttcggaaa acgccaaaaa 875341 agcgttccgc gaagaaattt taatccgcat ctcggcctat gcgagaaaag gcaagcggtt 875401 tgattacaat tcccatgaaa gactgcgtga agctattcag aaaaagctgt ttgctgatct 875461 gaaggatgtc gttaaaatta cgacctcaac aaaaacgccg gatgagcagc agctgaaaaa 875521 ggtaaatgaa gtcgtggccc gtttaattga tgagcacggc tacaactcga cgagcgccaa 875581 tgagctgctg aaatatgtcg gcagcctgct gaaccgataa gcaacgtgac ccgtccgaat 875641 agggcgggtt attttgtccc attttctaaa tagtttgtca attaaacgtg catatgtgca 875701 tatgatgaat ataaatcttt tcaaaagact tgtttcataa tctggcacaa gccggaatac 875761 gtatgtatca cgaccacaaa tggttaagga ggggaattca tgtcccaaaa tgacagcggc 875821 cattttttga tttctgagga aaactggtcc ctccatcgca aaggcttcga tgaccagcag 875881 cgccaccaga aaaaagtgca ggaagcgatc aaaaacaatc ttccggacct cgtaactgag 875941 gaaagcatta ttatgtctaa tggaaaagat gtagtgaaga tcccaatccg ttcacttgat 876001 gagtataaaa tccgttataa ctatgataaa aataaacatg tagggcaagg agacggcgag 876061 agccaggttg gagatgttgt ggcccgggat ggatcagaca aaaaacaagg gcctggaaaa 876121 gggcagggtg ccggtgatca ggcaggcgag gattattatg aagcggaagt ttcattaatg 876181 gatttagaag aagcgctttt taaagaatta gagcttccga atctccagca aaaagagcgg 876241 gacaatatca ttcatacaga tatcgagttt aatgatatcc gtaaaacagg gttaaccggt 876301 aatattgata agaaaagaac gatgatgtca gcctttaaac gaaacgcaat gtcaggaaaa 876361 ccgtcgttct acccaattta tccggaggac ctgaaatata agacgtggaa tgacatcaca 876421 aagcccgaat caaaagccgt cgttttagcc atgatggata caagcggcag tatgggggtt 876481 tgggaaaaat acatggccag aagcttcttt ttctggatga cccgtttttt gcggacaaaa 876541 tacgagactg tggaaattga atttattgcc catcatacag aagcaagagt ggtctcggag 876601 gaggattttt tctcaaaggg agaaagcggc ggaacaattt gttcttccgt atatcggaag 876661 tcgcttgagc ttattgatga aaagtacaat cccgcccgct ataacattta cccgtttcat 876721 ttttctgacg gtgacaacct gacatctgat aacgcgcgct gtgtgaagct ggtcaatgat 876781 attatgaaga aggccaatct gttttgctac ggcgaggtca atcagtacaa caggcattca 876841 acgttaatgt ctgcatataa aaatgtaaaa gatgagaaat ttaagtacta tattttaaaa 876901 cagaaatctg atgtttttca ggctctaaag aactttttca gaaatgaaga gtctggtgta 876961 agccatcaat tttcgtaatg aaaagcccat ttcagggctt ttttttattt aataaaagca 877021 agaaaacgct tgcgaaaaaa atacgggaga aaaagaaatt tttcctttga caaatcttct 877081 ttcatttatt aatattttat cttgtgaact attattgagg aatgaggtga aaaggagttg 877141 actgaatcag aacgtgcttt gctcactttt gaacagctct tcgatacgtc tcgggcgata 877201 tataaaaaac agaagaagat attggagatt gtgcttgagc cttttgatat tacagtcctt 877261 caatatttgc tgatgtttaa aattcatcaa agcggaagca ccccgctaag caagctggca 877321 atgtcgcttg atcttaagcc tgcttctgtg acgcggatga cagatattct gtataagcgc 877381 caattgatga atcgatatga cagtccggat gaccgccgta tcgtcatgat tcagttaacc 877441 gaagaggggg aagaactgat agaaaaagcc gctgtgcaat atgcaaaaat gggtgctggc 877501 ttgtaccaaa agcttgatac ctcccagctg cagtatttgc gcaaactagc cggaagttta 877561 acgaagcttg ctgaaggctg ttcagaaaaa agcggtaatt aaaaacttct cacatatttt 877621 caccagcttt ccgcaaaatg atagaggatg aaacgaaagg agaaaacaaa atgaacagag 877681 gacgtttaat tctgaccaac attatcggtt tgattgttgt tcttgcaatt atagctggag 877741 gtgcttacta ctattatcaa agcacaaact acgtaaaaac agatgaagca aaagtagcgg 877801 gcgatatggc tgctattact gctccagcag caggtaaagt atctgactgg gatctggacg 877861 aaggaaaaac agtgaaaaaa ggcgacacag ttgcaaaaat caaaggtgaa caaactgttg 877921 acgtaaaatc cattatggat ggcacaattg tgaaaaacga agtgaaaaac ggacaaaccg 877981 tacaagctgg tacaacaatt gcacaaacga ttgacatgga caacctatac atcacagcaa 878041 atattaaaga aacagatatt gcggatattg aagtaggaaa tagtgtagac gtagtagttg 878101 acggagaccc tgatactaca tttgacggta ctgtagaaga aattggttat gcgactaact 878161 caacttttga tatgcttcct tctacaaatt caagcggaaa ctacacaaaa gtaacacaaa 878221 aagttcctgt gaaaatttca atcaaaaacc catctgataa ggtgcttcct ggaatgaatg 878281 catctgttaa aatttctgag taaaacagat cagtcatcaa accatgaaag gaggttgtct 878341 tagatggcta caggcaaaga aaaaaatgca aaaaacccta tgtcattgct gattgtgcta 878401 atggcgggtt tatttttggc aattctaaac caaacactgc ttaatgttgc aatgccgcac 878461 ttaatgactg aatttggcgt aagtgcaacg acgattcagt ggctgacaac aggttacatg 878521 cttgttaacg gtgtattgat tccgttatct gctttcctga ttacacgatt tggccagcgg 878581 agtctctttc tcgtcgcgat gttttgtttt acgctcggta cgttagtctg cggtatcgca 878641 cctaacttct ctacaatgct gatcggccgt ttgattcagg ccgtgggcgg aggtatcttg 878701 cagccgctcg ttatgacaac cattctgtta attttcccgc ctgaaagcag ggggaaagga 878761 atggggattt tcgggctagc gatgatgttt gctccagcgg tcggcccgac tctttccggg 878821 tggattattg agcattatac atggcgcatt atgttttacg gacttgtgcc gatcggcgca 878881 attgttatca ttgtggcttt cttcatcttt aaaaatatgg tggagccgca aaaaatcaaa 878941 ctcgatactc ttggcgcaat cctctcgatt gtcggattcg cctccttatt atacggagtc 879001 agtgaagccg gatctgacgg ctggaccgac ccgattgtat tgtctacagt tattatcgga 879061 gccattgcaa ttgttgcttt tgttgttcag caattgcgtc atgatgatcc gatgcttgat 879121 ttcagagtgt ttaaatatga cattttctca ctctcgagtg tcattaatat cattattaca 879181 gtggcacttt acactggtat gttcctttta ccgatttatc tgcaaaacct ggtcggcttt 879241 acggcgcttc aatccggtct gcttctgctt ccgggtgcga tcgttatgct gattatgtca 879301 ccgatctcag gtattttgtt cgataaattc ggaccgagac cgcttgcgat tatcgggctt 879361 ctcgtgacag tggtaacaac gtatcaatac acgcaattga caattgatac accatataca 879421 cacatcatgc tgatctattc aattcgtgca tttggtatgt ctctcttaat gatgccagtc 879481 atgacagccg ggatgaacca gcttcctgcc cgtctgaaca gccacggaac ggcgatgagt 879541 aacacgcttc gccaaatcag cggatcaatc ggaacaagtt taattacgac gatttataca 879601 aaccggacga cattccatta ttcacaaatt gcagataaaa caagcacggc ggacccgaac 879661 ttcctccatg cgttccaaaa tgcagtttcg aatttaatgg tgaatatgaa tgtgtcttat 879721 gatacggcga aaacatatgt gtactcacat atttataaac acgcatcact cgattccaat 879781 gtcatgggga taaatgatgc ctttatgtgg gcaaccttat tctgtgtagc aggtttgatt 879841 ttaagtatct tcctgcgtga cgtcagaaaa gataaattgc gtaagaagaa aaaagaggag 879901 ctttcattac ttcctgctcc aaaagaagct aaggaatctt aatctgtaca gggaggtttc 879961 ctgaatgaaa atttatgtag tgtatgatag tgaaggcgaa catactaaag tgcttgcaga 880021 agcgattgct gaaggcgcga gagaaaacga cgcggctgaa gtgttcatcg accatgtaga 880081 tcaggctgat atccgcaagc ttaaagatat ggatgcgatt atttggggat gcccagggca 880141 tttcggaaca atcagctccg gtcttaaaac ttggatcgac agacttggct acttgtgggc 880201 tgaaggcgag ctgatcaaca aagtcggtgc tgtcttctgc acaacggcaa caacacacgg 880261 cggcttggaa atgacaatgc acaatttaat cacgccgatg ttccaccaag gcatgattgt 880321 tgtcggactg cctggcaacg tgcctgaaaa cgcactttat ggctcttatt acggagcagg 880381 tgtcacttgt ccggtagaca gtgatgagtt aatgtctgag gaaggtattc agcttggacg 880441 cgcgttggga agacgtgtca gccaagtcac aggaaaccta acagcaggac agtaaggaga 880501 ggttgaaatg gccattatta tagcaataat tgctgctgtc attgtcattg cggcccttat 880561 tacatttaac gtccgcaacg cctcacctgg acctgagaag caagaagcaa ccgatagaat 880621 cgcacctcca gaagaggaaa aaaacgaagc gcattaccct gctgaagcaa gggctgccga 880681 gcatacgcca tccgttgtca aaaacgattc tccaaaagag aagcgtgaca caatgggtga 880741 tgatatttac aggcaggcgc tgcaaaagtt taagcattct gatgaagttc atgcagaaga 880801 agaggtcact gaggaaagtg acaaaatgca ggaccgcagc tatcgtgatg cgctgctctc 880861 tatgaaaaat aagaaaaagt aatgaaaaag gcaaatccgt ttactcatgc gggtttgcct 880921 tttttgctgt ttccatcaat tatgttttta tcaaataaat ccatggaata tgttgtattc 880981 caccttgatc tagtgtacta tgttactcat acaccgagga ttttttccgg gaggtaaaga 881041 catgaattct tttttaggtt tattaaagaa agatatcaag ctttcaagaa tgtggctgct 881101 agtatggata tgcggaatca ttttcttatt gggaacaggc catattatag cttctcgcac 881161 gaaagaacct ctagtcattt ttggtttttt tgttgcagtt gctttttttc tgcttttctt 881221 atctcctgtt tttgtttttt atcaccttcg caaggaaggg aaatcacagc tttggctgta 881281 caatccaaat ggcggcttat ggctgttttc ttctaaattg gcagcatctt tgctctatca 881341 atttgtgatt cagttggcat taacagccta tggcatatgg atgtatcata tgctctctgt 881401 aaaaaatctg ctggagcatc aagttgatat aacgagtaca gtggctttgc tgaatatgta 881461 tgggcttatt tcttcgttag atatgtcagt aacagtcatt gtgttttgga ctgtttttca 881521 ctctctcaga aattggcgcg gaatgcggtg ggctgcgatg gttctgttgg tcgcaatgtg 881581 gttattcttc gatgaataca tcataagccc tttggttgaa tctcaaaagc atttctggcc 881641 tgtaacagtc tattgcaatt ttgatttcca cttccacaat gtttggagat tggaactaaa 881701 acctatccat ctgtctgtgc tagggtttcc tattgctata gtcatcacat tcttgctgct 881761 catcatggct tcaaaactgc ttgatcgtaa agtagaggtg taaatatgga caatcaattc 881821 caatcctcga aaccgattta tctgcagatc gctgatcaga tcttttatag gctggtcagg 881881 aaggagctgc tcccaggaga caagcttcct tcagtaagag aaatggcgat tcaaactaaa 881941 gtaaatccca atacaattca aagaacttac agtgagatgg aaaggctggg tattgtggag 882001 acaagaagag gtcaagggac gtttattgcg gaaaaagcag aaatcgtaga cgagctgaaa 882061 gacaagctga cacgagaggt gctggaaggc tttgtcaagc aaatgaaaga gctggggcta 882121 acgaaagaag aaatgttaga agggattaaa acattcacag agggaggcta aaatggaaat 882181 caagctagaa catgtatcaa aaaaatacgg ccgccatacg gccgtcaatg atgtgtcaat 882241 caccctatca tccggacgga tttatggcct gattggaccg aacggcagcg gcaagtcaac 882301 gaccctgaaa atgatggctg gccttctgtt tccgacttca ggatttgtaa aagttgatga 882361 agagcaggtt acgagagaaa tggtgcgtca aacggcttat cttactgagc ttgatatgtt 882421 ttatccgcat ttcactgtta aagatatggt gaatttttat cagtcgcagt ttcctgattt 882481 tcatacagaa caggtttata agctattgaa tgagatgcag ctgaatccgg aaaaaaagat 882541 caaaaagcta tcaaaaggaa atcggggcag gctgaaaatc gttcttgctt tagcgagacg 882601 ggcagacgtc atcttgcttg atgaaccttt ttccgggctt gatccgatgg tcagggattc 882661 catcgtaaac agccttgtgt cgtacattga ttttgagcag cagattgtcg tgatcgcgac 882721 acatgaaatt gatgaaattg agactttgtt agatgaagta atcatcctcg ccaatggaga 882781 aaaagttgcg cagcgtgaag tagaagatat tcgtgaacag gaaggcatgt ctgttttgca 882841 atggtttaaa tcaaaaatgg aagtttgcta gaaagaggag gaatatgatg aaaacagtgt 882901 tggaattgaa aaacgtgact aaaaacatca gaggccgaac gatcattgat gatctcagtt 882961 ttacgattcg tgaaggcgag gtattcggtt ttttaggacc aaacggagcg gggaaaacga 883021 caaccatccg gatgatggtg gggttaatga agctgtcgaa aggtgatgtc ctcatttgcg 883081 gccaatcaat tacgaaagaa tatgccaagg cgattaagca tatcggagcg atcgttgaga 883141 atcccgagct gtataaattt ttgagcggat ataaaaatct ccagcaattc gcaaggatgg 883201 tcaagggtgt cacgaaggaa aaaattgatg aagttgttga actggtcggt ttaacagaca 883261 gaatccacga caaggtgaaa acatattctc tggggatgag acagcgtctt ggcttggcac 883321 aatgccttct gcacgatccg aaagtgctga ttttggatga accgacaaac ggccttgatc 883381 cggcggggat cagagaaatc agagatcatt taaagaagct gacccgagaa agaggaatgg 883441 ctgtcatcgt ttcaagccac ctgctgtcag aaatggaact gatgtgtgat cgaattgcga 883501 ttctgcaaaa aggaaagctg atcgatattc aaaatgtaaa agatgaaaac attgatgaga 883561 atgatacata tttcttccag gttgagcagc cgagtgaagc cgctactgtt ttaaatcagt 883621 acgatttgct gagtaagaca aatggtgtag aaatcaaact ggctaaagag gaagtccctg 883681 cggttattga attgctggtg atgcagcaaa tccgtattta tgaggtcaag gtcataacaa 883741 aatcattaga ggaccgtttc ttagaaatga caggtgaaac aaaagaggag gttcagcatg 883801 cttaatttga tttataatga gtggctcaaa attttcagcc gtgccggaac atgggtgatg 883861 atcggaattc tggggctgac aatggttgga tttgcatttt tggcgaatca tttttctgcc 883921 ggtgaatcaa attcccattg gaaacaagag cttcaagcac aaaacgccga attaaagaaa 883981 gaaatcaaag aagatccttc actgaaagat gggtataaag aaacaatcac actcaatgac 884041 tatcgcatcg agcataatat ccctagtgac acgggctata cggtatggtc ttatgtaacg 884101 gattcagcaa actttaccat ccttaccggt ctgtttacta ttatcatcgc ggccggaatt 884161 gtcgcgaacg aatttaattg gggaacgatt aagctattaa tgattcggcc gctcagtcgt 884221 tttcaaattt tgatgtccaa atatattaca gttctcctgt ttgggctcct gttgctgttg 884281 attttattta tcggttctac tttattaggg ttgatcttct tcggaacggg tggtgaaacc 884341 gccgcgaata ttcatttaat ctataaggat ggccatgtca ttgagcaaaa catgatgggg 884401 catttggcta caacgtatct ttctgaatcc gtctcggctt taatggtggc gacgatggcg 884461 tttatgctgt ctgcggtatt cagaaacagc tctcttgcgg ttggtttttc catcttcttg 884521 ttggttgccg gtacgactgc aactgcattt attgcagcga aatttgactg ggcaaagtat 884581 atattgtttg ctaatgtcga cttgactcag tatgtggatg gcacaccgtt aataaaaggg 884641 atgactatga cgttttctct cgtcatgctg gcgatctact ttatcatctt cctgttgctt 884701 gctttcggaa tcttcatgaa gcgggatatt gcaaactaat aaaaaaagct gttttgctta 884761 tgcaaaacag cttttttgtc aaaataaaaa ctgcaggttt gcacctgcag tttttcatat 884821 caatttatgc ttacgcttct ttagtaacgt tagcagcttg tggtccgcgg tttccttcaa 884881 cgatttcaaa agaaacagct tggccttctt ctaaagtttt gaagccttcg ccttgaatag 884941 cagagaaatg aacgaataca tcgtcttgac cttctacttc gatgaatccg aaaccttttt 885001 cagagttgaa ccattttact ttaccttcta acatgaaatt tcctcctaaa gcgatcataa 885061 cgcttaaatt cactattctt gctcttaaca aactttcaag acgaaaactc ttacaaaact 885121 ttcttcttaa agatagttcg aacaaaaata attaccttta ctctaccagt aatcttcaga 885181 aaaaacaact gcttattgaa atttttttcg gaaaatacca tatttatttt tcaatttgat 885241 atttatttac ggaaattcat ctgttttctc gatatgtgat catacgtttg ccttagtatt 885301 ccttcatttt gggaagataa gtaataggaa ttgacaacct tattggatat gagtaaggta 885361 aaagttaatc aatattacaa atgacaacgt ttatcaacta agagagcgta tgatttttat 885421 gtctgatatt gcttgcatgc tctaatacat agataggagt atggtcacaa tgaaaaagtg 885481 gcttatatgc agtttcgtcc ttgttcttct cgtttcattt actgcatgtt caccgtctgc 885541 agaacatgaa tcgataaaaa tcgggattgc tgagtctgac ggggcaatat ggaactatat 885601 tgctcaaaag gctgaagagg cagggctgga tattcagctg atcccttttt ctgattatgc 885661 ggagtctgat atcgcacttg ctaacaaaga aattgatgcc aacgcctttc aaaccatttc 885721 atattttcag tcgttcactg aaaaatacaa acttaatttg gcaccgctcg ggacgacata 885781 cataacgccc atgggcattt attcaaaacg atatgaacga atccgagata tatcgcgggg 885841 agctgtcgtt tctgttccgg ataaagcgtt cgattttggc agggcgctta cggtgctcca 885901 ggaagcgggt ttgctaacgc tgaaaaacgg atttaacgga acaggttcag ttgatatgat 885961 taaagataat ccgagacacc tgaaattaaa agctgtccgg caacaggatg cagtgagcgg 886021 tgccgacgtg tttgtcatga aaccatcaga agcaaaaaaa gcgggcttga acccgaaaaa 886081 gcatacgcta aagagcggcg gactcatgtc tgaggaagag atgaatttga ttgttgtcag 886141 agcggaggat caagatcggg aagcgctgca aaccattctt gagctttatc aagctgatga 886201 tacagcggca tttatagaaa aagaatatca gggagatctt gtcccggctt ttctgccttt 886261 gaaacgtctt tcagattgga agaatgaatt cgaacattga attcattctt ttttttctga 886321 aaaacacact ctgttccgtc ccgtttcttt cgctttgtaa agcatttgat cggcaagaat 886381 gggcaaggat cctggctgtt ccgtattatt ggggtaatga gcggccccta gtgatatcgt 886441 aactgaaagc tcgtcgccgt ttgttaatac aatcggtgca tcacttacag tgctcctgat 886501 ccgttcagcg atccgggctg ctttatcaag agaacagttc ggcaggagca cggcaaattc 886561 ttcaccgccg atccgagcgg caggatcagt atttcggatg gtctgcttca gacgtaaccc 886621 tagctctttg agcacctgat ctccttcatg atggccatat tggtcattga tggtcttaaa 886681 atgatcgata tccatataaa tcagtgcaaa ttgaaaatgc ggggtatcgg ccgcctgctg 886741 atacagagct tttgtggttt cttcaaattt tcttcggtta tacacgcctg ttaaaaagtc 886801 aaagtgcgcc tgaaacttat attgtttaaa aagaagatgt gcatttgttt catgatcaat 886861 aatatataaa ctgagcatgc cgcccgctat tgatatgatc caaaaataca aatgaagttc 886921 gtatgaatgt aaatctataa gaaaataaaa ggaaaaggag atcaagctat ttgtgattat 886981 taaaagatag aaagcatgtt ttagttgaac tttttttctt ctagaaacaa tgagtgacgg 887041 aatggcagcg atacaaatga taataaccga gtatagtgca gatgtgttca tcgtaatcag 887101 caagcggcct gcagtgatca tggccagggc cgttgccgtt gaaacccagc ctccataaag 887161 agcggcaatc ataataggga tatttcgaag atcaataatt gaatgctgat aggtaaatcc 887221 aaaaaccatc agaataaccc cgagcaaacc gcaggccagt cctttaacag cttgaaagga 887281 tatgctgtct tttttatgta ctagcctttc tttaaacagg tgggtgaaga gataattaaa 887341 tgtgattaaa atggtcaaat ttacaaacag ttctttcagc aaatattatc acccttatat 887401 aaggtactaa agatggaagg gaaagaaaag aacaaaaaag gcattatata aggttttttt 887461 acttgaattg ataagttaaa ataattcgca cttgacccat cggaattagt gtaatatagt 887521 aaatgagaaa atttgaaggg agagtttacc tgctttggag actttactgg ttgtattaca 887581 tgtatttatt ttatttttac ttatcttagg gctctttgtt atgcagaaaa aacatgtttc 887641 cttctctaaa cgtgtattta ctgcgctggg gctggggatt gtattcggat ttgcgcttca 887701 gctgatttac ggcccgactt caaatatagt cattcaaaca gccgactggt ttaatattgc 887761 cgggggcgga tatgtcaaat tgcttcagat ggttgtcatg ccgctcgtct ttatttcgat 887821 tctcggcgcc tttacaaagc tgaagctgac aaaaaatctt gggaaaatca gcggtttgat 887881 tatcgggatt ttagtagcaa caacagcagt tgctgcagct gtcggtatcg cgtccgcgct 887941 ttcatttgat ctgcaggcga ttcaggttga ccaaggaagt acagagcttt cacggggaca 888001 ggagcttcag cagaaatcag aggatatgac agcgaaaacg ctgccgcagc agattgttga 888061 actgctgcct ggaaacccgt ttttagattt tacgggagct agaccgactt caacgatcgc 888121 tgtcgttatt tttgccgctt tccttggagt ggcattcctc ggcgtaaaac acaaacagcc 888181 ggaacaggca gaaacattta aaaaactggt tgatgccgtt tatgccattg tcatgcgtgt 888241 tgtcacactc attttgagac tgacgcctta tggggtgctg gccatcatga caaaaacaat 888301 tgcaacgagt gatcttgaca gcattctaaa actgggcatg ttcgtgattg catcatatgc 888361 cgcgttaatc actatgttta tcattcattt gctgctgctg acgttcagcg gcttgaatcc 888421 ggtgatttat ttgaaaaaag cggtgcctgt acttgtattt gcatttacgt caaggtctag 888481 cgcaggtgct ttaccgctga atattaaaac acagagaagc atgggtgtac cggagggaat 888541 cgcaaacttt gccggttcgt tcggtctttc gatcggccaa aatggatgtg ccggcattta 888601 tcctgcgatg ctggcgatga tgattgctcc gactgtcggc caaaatccat ttgacccggt 888661 gtttattatc actgttatcg cagtcgttgc catcagctcc ttcggggttg ccggagtcgg 888721 cggcggagcg acattcgcgg cgcttcttgt tttatcatca ttaaacatgc ctgtcgcgct 888781 cgccggtttg ttaatctcaa ttgaaccgtt aatcgacatg gggcgtactg ctttgaatgt 888841 cagcggaagc atgacatccg gtcttattac aagtaaggtc acaaaagaaa ttgatcaagg 888901 ggcatttcat gatcaatcca gagtgattga agctgaagaa gcgtaacata tgaaaacgtg 888961 taatccaaga ggattacacg tttttttaac ggccaggctc taagtcctcc agcatttcca 889021 tcatcgtgtt gtcgtccatg acattcattg cgttttgttc aaaatgaatg ggttcagcat 889081 aatgcggctg tctttttttc gcggctgtct cagtttgcct agtttgagac tgtgtatgct 889141 gatgctgtgg ttgctgctgt ccagcgtgct ggtgctgacg gccattttgc cgctggcttt 889201 gatgctgcga acggtcctgg ttatcaccgc tgcttccgct gcttccgcta aatgcttgtt 889261 tgaccatgtt tcctacatta gaagcatcaa acgtgttatt ttctgaattt cgtctgttca 889321 tttgtcctgt gataaacccg ctgattcttt ggcggatctg aggtgataat gcagtaataa 889381 gcatagttga tcctatgatc aatgctgcgg ggctgattcc tcttcgctgg ttgaacaaca 889441 tgatccctcc tttgcagtgt attcatattt tccccctcgt tagacaaatt aaccgttata 889501 tttcccggga aagcatttcc tccagatttg catgcataat taaagccagt tagaaaaacc 889561 tataagtaaa gtgataaagg aggaattcac atgtttggaa aaaaacaagt ccttgcgtct 889621 gtgcttctta tccctttgct tatgactggc tgcggtgtag ccgaccaagg tgagggcaga 889681 cgtgataata atgatgtaag aaacgtaaat tatcgaaatc cggccaatga cgatatgcgg 889741 aatgtaaaca atcgggataa cgttgacaac aatgttaatg ataatgtcaa taacaatcgt 889801 gtaaatgacg ataataacaa cgaccgaaaa cttgaggttg ctgatgaagc agctgataaa 889861 gtaacagacc taaaagaagt aaagcatgcc gatatcattg tggctggaaa tcaagcctac 889921 gttgcagtcg ttttaaccaa tggaaataaa ggtgcagtag aaaacaatct gaagaaaaaa 889981 atagccaaaa aggtaagatc tactgacaaa aacattgata atgtttacgt ttcagctaac 890041 cctgattttg tagagcgtat gcaaggatat ggaaagcgta ttcaaaatgg tgacccaatc 890101 gccggattat ttgatgaatt tacacaaact gtacagcgtg tattccctaa cgctgaataa 890161 atgaaagaag ccgcacaatt tgtgcggctt tttctttgcg ttaatgacac actgcgaact 890221 caggctgcat agagtaaaaa taaaaaggta caagacggac cggctcaggg agggagacgt 890281 ttgcgggatg gcataggaaa gcgtgcggca tccgctctat tcctgtgcgg agtccttgtg 890341 atgctggctg taagctcagc catcgtatca agcgcgatgt atatcctgtc ttttccaggt 890401 caggcatctg gaataacaaa agaacaagtg acgaagcaca tgaagaaaga gtcattcaaa 890461 caggccgata tttattacac ttctaaggaa aagtccttac tgccattgac gaaagaaacg 890521 cttgaatatg cggtcagtat taatcagatt atgattggat attcgaatca aaagcctatt 890581 gacattattt tttttcctaa tgaaaaacag atggaggctt actccggttt attggatgta 890641 gttggttttt attctgaacg ggagcagctg atcggattgt tgcctgaaga gaaaaagaaa 890701 ctgttagaag gggacgaggt agcggtttat ttgtaccaga gattgttgat tcatgaatac 890761 tcgcaccatg cgtttcacca gaaattgaag gagcttgaga cggatcccga tgagtttccg 890821 ttatggtttc atgaagggtt aagcgagtgg attgcgaact atgaattgct catagatccg 890881 atcacgtttt ctgtcgtgcc ctttgaccgt ttgcagactg atcgagactg gcaggaagct 890941 agagccgaat atgacactga tgtctatttg caaagctttt atatgatcga tgagctgacg 891001 gacaaatacg ggaaagacat tatttcagaa atgattaagg aaacggcaaa aaaaggggac 891061 tttgaaaaag ggtttaaatc agcaacaaag gaaagtcttg atcaatttga aaaagatttt 891121 aagaaaaaat ttgaaaaaaa cagtgcggca ttggatagta tctatccaat gcctttgtta 891181 ttagtgaagt ccttgctgac ccattccgcc ttgtgtcgga ggcatttgtc cttgggcagg 891241 ggcgaatgaa tttcgcagct gttccatatc ctgcgcatca agctgaggaa cctggtaata 891301 gccgtgtttg ttttggtata ggaaaatttc aaatgccatt tcaacatact cctgaatttg 891361 cgcagacagt acgcgtctta cggccggatt tgtcatttcc agagaagcca tcgtcagcat 891421 agaagcttgt gctttaatcg cgcaaagcat ttgtcggctg atgatgctgt catcaatatc 891481 attcatggat tgaacaggtt ttttaggctg tgacggctgc atgccgtaaa cagtctggtt 891541 gtcttccttc atcatataag ttgctgtttt ttgtgaaggt tcgcttcctg ttttgaagca 891601 ttctgcagtt atattgtatt gagatgtgat gaattgatgt tgacgatcaa ggatgtttag 891661 taattcttga tccttacaga attgtctcag catcataaac tgatcaagca cagtaagtgt 891721 tccggaaagc acctcatgca tatcaaacat ttcatgtccg ccgtggtttt tatgcggttt 891781 gccaggaata cctttgttca tttgggattg ctgctgctga ttgaactgat ccaaaccgaa 891841 ttcctccttt tttttcagat cagctgtatt ttgtgtcagt ctgccgtgta ttatgcagaa 891901 gcctgaaagg aattatatgc tgtctgtcga aatgataagc agacaaaatc gttgtcatta 891961 tgtgtataag ggaggaaata tgatgaggcg tattctgcat attgtgttga tcacggcatt 892021 aatgttctta aatgtaatgt acacgttcga agctgtaaag gcagctgaac cgcaacagcc 892081 tatatcgatt gagaaggcaa tacagcaaaa agaaggacag gcacttgtcg aaggatatgc 892141 agtcggccag gctgtttccc cgcagcatta taaactgaca agcccttttt caaatgatta 892201 taatgttgcg ctggcagacc gtaaaaacaa aacatcgccc gaacacatcc ttcctgtgca 892261 aatcccctcc gccttcagaa gccaatttgg gctgcaaacc aatccgcttc ttcttgggaa 892321 aaagataacg gttcaaggaa agcttgaaaa ttactttaac acgacaggac ttaaaaacgt 892381 tcagtcgatg aacgtaaccg atgacacaaa aactccgccg gctgaacagc aagtgaccat 892441 aaatgaagca cggggaaggc tgaatgaaga agtaacgata aaagggatca ttacagctga 892501 tcaaaacgca atcggaggcg ggaagctgtc gacctttttg caagatgaaa ccggaggcat 892561 taacatttat tcgccatccc ctgaacaatt tcccgaatta aaagagggta tggatgtcac 892621 ggtgacaggg aaaatcacgt cttaccaggg gctgaaagaa atcgttccaa actcatcagg 892681 catcaaaatc aaccagtcaa atcaatccct ccccgccccc aaacacttaa caatcaatga 892741 acttattaac ggcagcctag gtgatcagta tgaaggacgc cttgtgaaac taaccgcttt 892801 tgtttcctca attccaagtt ctcctgccgg cggcggttac aatgtaacaa tgattgatga 892861 cgaccatcat gcaatgacgc tccgggttat gaatgaaaca ggggtgataa acgagcttga 892921 tgagggcaaa tggtatgaat ttaccggtgt gttaagcaga taccaaacct ttcagctgct 892981 tccgcgaaaa tcggctgacc tgaagctgct tgaagagcag cccgcacctc cgtctgcaga 893041 gggagaatat gaagggattg ttgaccgggt agttgacggc gataccattc atcttaaatc 893101 tccggtgctt ggaacgacaa aaatccggtt tgtaaatgta gatgcacccg aaacatatca 893161 cacaccaaaa aatgacgcag atgaaaatca attaagattt ggcaaaaaag catctgacta 893221 tctaaaaacg gttctgtccc cgggtgataa aattactgtc aaggtcggga gtgaagccaa 893281 ggacagctat ggcagattgc tcggacaagt cataaccgaa tcaggttcaa acgtgaactt 893341 agagcttgta aaaaacggct atgctccgac gtattttatt tggccggttg acaatgaaga 893401 ggattatcag caatttcagg ccgcagtagc cgctgcaaaa aaagatcaaa aaggaatttg 893461 gaatgaaaac gatcccctca tggaaatgcc gtttgaattc agagccagag agcaagggaa 893521 aggcctgaca agatatgtgg gggactcgtc gaataaaaca tatgtgcagc cagctgactg 893581 gaagaagata gctgtggaaa acagaatttt cttcgcctca gcaagtgaag cggagagcgc 893641 gggatataaa aaaaggcaaa cggcacctca agaacatgtg ccgcttagaa ttctcagcat 893701 gaatgatttg catggcaaaa tcgatcagca atatgagctt gatcttgatg gaaatggaac 893761 tgtagacggc acgtttggac gcatggatta tgccgccgca tatttaaaag aaaaaaaggc 893821 tgaaaagaaa aactcgctga ttgtgcacgc gggagatatg atcggcggaa gctctccagt 893881 ttcctctctt cttcaggatg aaccgactgt agaactgatg gaggacatcg gatttgatgt 893941 cggaaccgtg ggaaaccacg aatttgatga aggcacggat gaacttctga ggatcttaaa 894001 tggcggtgat catccgaaag gcacaagcgg atatgatgga cagaactttc cccttgtatg 894061 tgccaattgt aaaatgaaat caactggaga gccctttttg ccggcttacg acatcattaa 894121 tgtggagggc gtacccgttg cttttatcgg agttgtcaca cagtcggcag ctggcatggt 894181 tatgcctgaa ggaataaaaa atatcgagtt tacagatgaa gcaacagcgg tgaataaggc 894241 ggccgaagag ctcaagaaaa aaggcgtgaa ggccatcgcg gttctcgcac atatgtcagc 894301 tgaacaaaac ggcaacgcca ttaccggtga gtctgctgat cttgcaaaca aaacagattc 894361 tgaaattgac gtgatttttg ccgcgcataa tcatcaggtt gttaacggtg aagtgaatgg 894421 aaaactgatt gttcaagcgt ttgaatatgg aaaagcgata ggtgtcgttg atgtagagat 894481 cgataaaacg acaaaagaca ttgtcaaaaa gtccgcggaa atcgtatatg ttgatcaaag 894541 taaaatcgaa ccggatgtca gcgcgtcagc cattttaaag aaatacgaaa caattgcgga 894601 accgattatc agcgaggtag tcggcgaagc cgctgttgat atggaagggg ggtattcaaa 894661 tgacggcgat acacctcttg gaaacctgat tgcggatggt atgagagctg ccatgaaaac 894721 ggattttgcc cttatgaatg gcggcggcat acgtgaagcg ctgaagaagg gtccaattac 894781 gtggggagat ctttacaata ttcagccgtt tggaaatgtg ttaacgaagc ttgagattaa 894841 aggaaaagat ttaagagaga ttatcaatgc gcaaatctcg ccggtttttg ggcctgacta 894901 cagcatcagc gggtttacgt atacgtggga taaagaaacc ggaaaagcag ttgatatgaa 894961 aatggcagat ggcaccgaga tccagcccga tgccacatat acattgaccg tcaacaactt 895021 tatggcgacg gcgacaggag ccaaatatca gccaatcgga ctgctgggaa aaaatccggt 895081 gacagggcct gaggatttgg aagcgacagt tgagtacgtg aagagttttg atgagccaat 895141 tgcgtataca aaagagggaa gaattaagct tgctgaagcc agtgatattg aagaccctgt 895201 aacagaagac ccgataacgg aagagcctgg agatgatccg gggacggagg atccgattaa 895261 agaggatcca aggccaggtg aagatttgcc tgatataaaa gaaactccgg gaacagcacc 895321 ggttcatcag cttccgcctt cagccatttc gagattcaat gaaataccaa tcaacaacac 895381 aaaaaccgct gatactgcta atagcatcag cacattgccg ttacaaaccg agactgcgga 895441 aagcgggtct gatcatcagc ttccggatac gtcagcgggc tactataact ttatggtaat 895501 cggtgcggcg gtgacattgt caggaactta tctatatgtc agaagaaaaa ggagcgcctc 895561 cagaacgtga aaaaagttat tccactattc atcattgctg ccggcctagt gatcgcaggc 895621 tatggaggct ttaaattgat cgatacgaat acgaaaacgg aacagacatt aaaagaagca 895681 aagctggcgg ctaaaaagcc gcaggaagct tcggggacga aaaatagcac agatcaagca 895741 aagaacaaag catcatttaa gcctgagacc ggccaagcga gcggcatttt agaaataccg 895801 aaaatcaatg cagagcttcc gatcgtggag ggcaccgatg ctgatgattt agaaaaaggt 895861 gtcgggcatt acaaggacag ctattatcct gatgaaaacg gacaaattgt gctgtcaggg 895921 catcgggata ccgtgtttcg ccggacggga gagctggaaa agggggatca gctccgtctt 895981 ctcctgtcat atggagaatt cacatatgaa attgtaaaaa caaaaattgt cgataaggat 896041 gacacatcta ttatcacgct ccagcatgaa aaggaagagc tgattctgac gacctgctat 896101 ccgttttcat acgtcggaaa tgccccgaag cgctatatta tatatggaaa acgagtgact 896161 taaaaagccg aggcagtgcc tgcggctttt cttcatgaaa aatatgtgcg gcaaaggttt 896221 ttcatatcag cagggaaagg ggcttcagca actatgagct cgtctgttat cgggtgaacc 896281 gcttgtactt tattggcgtg cagtgcctgc ctgtttagca gcttgctccc gcctccgtaa 896341 agcgagtctc ctgtcaacgg atggccgagg ctcgccagat gaacacggat ttggtgtgtt 896401 ctgcctgttt ccagctctaa ttcaacgagc gacagccgtt ctttcgcatt gctggccatt 896461 accttgaaat gagtgacggc tgtttgcccg cctggtgaaa cccggcgtct tgtcgggtgt 896521 gagcggtctc tgccgatcgg tgaattaatt gtcccttttt tcgtccgtag cttaccttca 896581 gcgatagcgg tatacgtacg cttcagcgtc tttttctcta actgctggtc taagatggcg 896641 tgtgccaaac gatgcttggc aaaaacgata gcgccagatg tatcctgatc aagacgatgg 896701 acgtggcgca ccttacatgt ttcgccattt atctgataat gatacgcgat caaattagcc 896761 agtgtgccgg tttgcccatc ctcattcgga tgcgtcgcga tgccagcggg tttattgatg 896821 atgagcatat gattgtcctc aaataaaata tcaagctcgc catactccgg aatgaccgaa 896881 gatgcttcac tttcctgaag atcaatgaac acgcggtctc ccttttttac aatcatattg 896941 tttaagacgg attcgtgatt gacctttatc tgttgatggg acatccagtc ttgtatcact 897001 ggtttagaag ctttgagcgc tgttttgagt acggaaaaca gccattggcc gtcctgtttt 897061 tcattgatga ggatctcaag ccctctgcct ttttggttca tgttaaatgg ctccttttcg 897121 aagcggaagg ctgctgtttc tcataggaaa cacttacctt agctttcgcg tttttttctg 897181 tgctattctt gagtaagact taggatattc gatggcaaga aaggtgattg acgtgagaat 897241 tgtgaacgca gcaactgcag aacaggagag ctttatcaag gagctgtcta tggagctgat 897301 ccatgatgta tttcctcttt atttctccga actggacatt cagcgcttta aaaagaaagg 897361 cgttctgtct ttaaataacc attattacca aggaacatta aaagaagcat ttcaaattat 897421 ggcttgtctg caaatgatac atattatcct gaccaagcct tcgccgcact ctgatttgag 897481 tgatcaggcg atttttgaaa aaaacagcaa gatgctgaat gattttggga tttattttcc 897541 gtttgctttt tctgactttc aaaagaagac taacaaagcc tttttcggtc aaagaaggct 897601 gatataatca tgcggcaagg gcttttctat ttttagaaaa gctctttttg tatcagagaa 897661 atcatatcat aaaacctttc ctctaactcc ctttttaaac ggctcgtgtc tgaacatact 897721 aatgattgaa aggggtgctg acaatgagtt cagttaaaga tacaatgaca acgcaggtgg 897781 caaccgtttc tccgaatcaa acgattcagg aagcggcttc tctaatgaaa cagcataacg 897841 tcggggcgat ccccgttgta gagcaaggtg ttttaaaagg aatgctgact gaccgtgaca 897901 ttgcattaag aactacagct cagggccgtg atggccagac acccgtttca gaagtgatgt 897961 caacagaact cgtatcagga aaccctaata tgagtctgga agacgcgtcg cagctgatgg 898021 cccagcacca aatccgccgc cttcctattg tagatcaaaa caatctagtc gggatcgttg 898081 cgcttggaga cctggcagtc aatcagatgt cgaacgagtc tgcgggatca gcgctgacaa 898141 acatttctca ccaaaacatt cattaataag aaagagcttg cagtgtgcag gctctttctt 898201 cacataaaac cttacttttt gaaagcagac ttgtttcggg gtatagtgag tgtatacata 898261 tgtctcaatt cgtactaaag gagttgtacc cagtgattaa agcgttaatt tttgattttg 898321 acgggcttat tctagataca gaaacacacg aatatgaggt tcttcaggaa atatttgaag 898381 agcacggctc agtgctgccg ctatctgtct ggggaaaggt catcggaact gctgcgggtt 898441 tccggccttt tgaatattta gaagagcaga tcgggaaaaa gctgaaccat gaagagctca 898501 cacaattgag aagagagcgg tttgccaaac gcatggaatc agaaaaagcg agacctggtg 898561 tcgaagcgta tttgaatgcg gcaaaggatt taggcttaaa aataggcctt gcctccagct 898621 ctgattataa atgggtgtcc ggccatttga agcaaatcgg cctgtttgat gattttgaag 898681 ttattcaaac ggcggatgat gtggaagagg tgaagccgaa tcctgaactc tatttattgg 898741 cggcaaagaa cctgggggta tcgccagcgg aatgtctcgc gtttgaggat tctgtcaatg 898801 gttcgattgc tgcgaaacgt gcaggcatga agtgtgtcat tgtcccgaat aaagtaacgg 898861 gtaccttgat gtttgaagac tatgatcaca ggcttgaatc aatggcggag atggagctcg 898921 ccctattgct tgatcatctg aactcacaaa actagaaagg agcgagtagg ttgtctgaga 898981 aattagattt gacccggttt gaaaagaaaa tggttatccg caatatcgaa gagaaagaca 899041 tcgacaagat tatcgatctt caaaaggact gctttccagg aatggagcct tggaagcggg 899101 agcatttaat cagccatttg gagcattttc cggaaggaca gttttgtgca gaattcgaag 899161 gtgaaattat cggttcgtgc tcaagtctcc tgattaactt tgatgaatat gatgaccgcc 899221 atacgtggca ggacattaca gatgacggtt atatcaccaa ccataatcct gacggcttga 899281 atatgtacgg aattgaagtc atggtgcacc cgaaatacag acgaatgaag atcggccacc 899341 gtttgtacga ggcgagaaag gacttagcca gacgcttaaa cctgaaaagc atcatcatag 899401 gcggacggat tccaaactat cacaaatatg cagaggaaat gacagcgaga gagtatgttg 899461 aacaggtgac acgccaccaa atttacgatc cggttctttc ttttcagctg atgaacggct 899521 ttacccttat gcgaattaac ccgaactatc tcccggatga tacagcttcg atcaagtatg 899581 cgacgctgat ggaatggaat aatgtcgatt atctaccgca gcagacaaaa cgctattata 899641 aatcggcgtt ccctgttaga atttgtgtga tccaatacga aatgaagaaa atttattcct 899701 ttgaggaatt tgcgaatcaa gtagaatact atgtcgatgt tgcttccgac gcaagatctg 899761 attttgcggt gttcccggaa attttcacaa cccagctgat gtccttcctt gaggaacggt 899821 caccgagctt ggcggtgcag agaattaccg agtatacaga agattacatc agcctgttta 899881 ctgacttggc tgtgaagtat aacgtcaaca ttatcggcgg atctcatttc gtcgaagagg 899941 aaggcaagat ctataatatc gcttacctgt tcagacggga cggaacgatc gagaagcaat 900001 acaaactcca tattacgccg aatgaacgca aatggtgggg gatcagcgca ggagaccaag 900061 ttcgcgtgtt tgatacggac tgcgggaaaa tcgcgatcca gatctgttat gacattgaat 900121 ttcctgagct tgcccggatt gcggctgata aaggagccaa aatcatcttt acgccatttt 900181 gtacagaaga ccgtcaaggc tatctgcgtg tcagatactg ttcgcaggct agagcggttg 900241 aaaatcaaat ttatacggtt atctctggaa cggtcggaaa ccttccgcaa acggaaaaca 900301 tggatatcca atacgcccag tcaggcatct ttgccccgtc tgattttgaa ttcgcccgag 900361 acggcattgt cggcgaaaca aacccgaata ttgaaatggt cgtcatcggc gatgttgacc 900421 tggaaattct cagaagacag cgccaaaacg gtacagtgcg ccagctaaaa gacagacgac 900481 gtgatattta tcatattcaa tataaaaaat aattcccaaa aaacccgcct gaattggcgg 900541 gtttttttaa acaaaagcgg aattgtttag gtgctttctt taaaataaaa gtaaattgta 900601 tagtggatgt gccttatgga gtttctgtat tttcgccatt tcctatatca tacagaaaac 900661 ggctaggctt cacattgcta ttgcaatggc tgtccaagtt gtttcgagtg cgacctttat 900721 cagtacgatg ctgagcattg tcactttgcc tgttttgctt tggaagctgc atcctctttc 900781 ttcttgagaa aggggatgtt ttattattta cgcggtttat tgactctgac ccggtctggc 900841 tttatattga aggcagggaa atcatcacca agacatcaca taaagagaag gtctgtttca 900901 attgaattgg cattataggg aacgctaatg aaatggagat gatggggatg gaaaacattc 900961 agcaaaatca gggattaaag caaaaagatg agcaatttgt gtggcatgcc atgaagggag 901021 cgcatcaagc ggacagcctg atagcccaga aggccgaagg ggcctgggta accgacacag 901081 acggacgccg ctatttggat gcgatgtccg gtttgtggtg cgtcaacatt ggttacggca 901141 gaaaggagct tgcggaggct gcctatgagc aactaaagga gctgccttac tacccgttaa 901201 cgcaaagtca cgcacccgca attcaactgg cggaaaagct gaatgaatgg cttggcggcg 901261 attatgttat ttttttttcc aacagcggat cggaagcaaa cgaaactgct tttaaaattg 901321 cccgccagta ccatctgcaa aacggcgacc acagccgtta taaattcatc tcaagatatc 901381 gggcatacca cggcaataca ttgggagcgc tctcagctac cggacaggcg cagcggaaat 901441 ataaatacga gcctttgagc caagggttcc tgcatgcagc tccgccagat atataccgga 901501 atcctgatga tgcagacacg cttgaaagcg caaatgaaat cgaccgcatc atgacatggg 901561 aattaagcga aacgattgcc ggggtcatta tggagcccat cattacaggc ggaggcatcc 901621 taatgccgcc ggacggatat atgaagaagg tggaggacat ttgccggcgc cacggagccc 901681 ttttgatttg cgatgaagtg atctgcgggt ttggacggac aggtgagccg ttcgggttta 901741 tgcactacgg tgtgaagcct gatatcatta cgatggcaaa gggaatcaca agcgcgtatc 901801 tgccattgtc agcgactgct gtgaaacggg acattttcga agcgtatcag ggggaagctc 901861 cttatgaccg tttccgccac gtgaacacgt tcggcggaag cccggctgcc tgtgctttgg 901921 cgttgaaaaa cctgcaaatt atggaggacg aacagctgat tcagcgatcc cgtgatcttg 901981 gagcaaagct tttaggtgag cttcaagctc tgagagaaca cccggcagtc ggggatgtta 902041 gaggaaaagg gctgctgatc ggaatcgaac tcgtcaaaga caaattgact aaagagccgg 902101 ctgatgccgc caaagtaaac caagtggttg cggcgtgcaa agaaaaaggg ctgatcatcg 902161 gcaaaaacgg cgatacagtc gccggctaca acaatgtcat ccagcttgcg ccgccatttt 902221 gcctgacaga agaggacctt tcctttatcg tgaaaacggt gaaagaaagc tttcaaacga 902281 tataatataa aagtgaatta ttaaaggagc acatgatgag ttttcacaac cagccgatct 902341 taccggctat tcgcaatatg aagcaatttg atgagttttt gaacagttca ttctcttacg 902401 gtgttattct tgatattcat ctcggccagc tgaagggcgt gatcaaagaa gcgcaaaagc 902461 acggaaagaa catgatggtg cacgtcgatc tcattcaagg gattaagcat gacgaatacg 902521 gtgcggaatt tatatgtcag gatatcaagc ccgctgggat tatttccaca agatcgaatg 902581 tgattgccaa agcgaagcag aagaaaattt atgccattca gcgcctgttt ttgcttgata 902641 caagcgcgat ggagaaaagc atggagttta tcggcaagca taagcctgac ttcatcgaag 902701 tgcttcccgg catcgttccg tcactcattc aggaaataaa agagaaaaca gggattccca 902761 tctttgccgg gggtttcatc cgtacggaag aggatgtaga gcaggcattg aaagcggggg 902821 ctgtagctgt cacaacatct aataccaaat tgtggaaaaa atatgaaaac tttttgacgg 902881 aaagtgattg acaccgcttt catgcactga tacaattgca ctaggttaat acattgtgat 902941 ggagaactcg gagaccacag cagctcttta cggcaaatgt ttatgcaccc gtaaagcggt 903001 ttgttgtggt ttttttattc tcttcttctc tatcatgctt tttaatcgtg actttaggag 903061 gaatgtgcta tgacagcatt ttggggagaa gtcatcggta cgatgctgct tatcattttt 903121 ggtgcaggtg tttgtgcagg tgtcaattta aagaaatcgc tttcattcca gtctggctgg 903181 attgttgttg tatttggatg gggattgggt gttgccatgg cggcatacgc ggttggcggc 903241 atcagcggtg cccatttgaa tccggcgcta acgatagcgc ttgcatttgt aggagatttt 903301 ccttggaaag aggttccggt ttatattgcg gcgcaaatga tcggagcgat catcggtgcg 903361 gtgattattt atctgcatta cctcccgcac tggaagtcaa cggatgatcc cgctgccaag 903421 ctgggtgttt tctcaacagg gcccagcatt ccgcatacat ttgcaaacgt tttaagcgaa 903481 gtgattggga catttgtcct tgtacttgga atcttggcca taggtgcaaa tcaatttaca 903541 gaaggactta atcctttaat cgtcggtttc ctcattgtag caatcggtat ttctctggga 903601 ggcaccaccg gctatgctat caatcctgca cgtgacttag gtccgcggat cgcccacgct 903661 tttcttccga ttccggggaa gggctcatca aactggaaat acgcatgggt tccggtagtc 903721 ggcccgattt taggcggatc attcggcggt gtattttaca acgctgcatt taaagggcac 903781 atcacaagca gcttctggat tgtaagcgtt atattggttg tggtattgtt aggactctat 903841 gtttatacga aatcacattc tgctaaaaca ttatcaaatt ctaaatatat ttaatcaaag 903901 gggagacatc ttatggaaac gtacatttta tccttagatc aggggacgac aagttcaaga 903961 gcgattctgt ttaataaaga aggcaaaatt gtccactctg ctcaaaagga atttacacaa 904021 tacttcccgc atcctggctg ggttgagcat aatgccaatg aaatttgggg ctctgtcctc 904081 gcggttatcg cctcagtcat ctctgaatca ggaatcagcg cttctcaaat tgccggcatc 904141 ggcatcacga accagcgcga gacgacggtt gtgtgggata aagatacagg aagtcctgtc 904201 tataatgcaa tcgtttggca gtccagacag acgtccggca tttgtgagga acttcgtgaa 904261 aaaggatata atgataaatt cagagaaaaa acagggcttt taatcgatcc ttacttctcc 904321 ggcacgaagg tgaagtggat tttagacaat gtggaaggcg caagagaaaa agcggaaaaa 904381 ggcgagctgc tgtttggaac gattgatacg tggctcattt ggaaaatgtc aggcggaaaa 904441 gcgcatgtga ccgattactc caatgcctca agaacactga tgtttaatat ttacgattta 904501 aaatgggacg atgaactgct cgacattcta ggcgtaccga aatccatgct ccctgaagtg 904561 aagccgtcct ctcatgtgta tgcggagact gttgattatc acttcttcgg aaaaaatatc 904621 ccgattgctg gagcggcagg cgaccagcag tccgcattgt tcggccaggc atgctttgaa 904681 gaaggcatgg ggaaaaacac ttacggcaca ggatgtttca tgctgatgaa taccggggaa 904741 aaagcaatta agtccgaaca tgggcttttg acaacaatcg cttggggcat tgacggaaaa 904801 gtgaactatg cgttagaagg gagcattttt gtcgcaggct ctgccatcca gtggcttaga 904861 gacggtttga gaatgttcca ggattcatcg ctaagcgaat cttatgcaga aaaagtggat 904921 tcaactgacg gcgtgtatgt tgttccagca tttgtcggac tgggaacgcc ttactgggac 904981 agcgatgtgc gcggttcggt tttcggcctg acaagaggga caacaaaaga gcactttatc 905041 cgtgcgacac tggagtcatt ggcttatcag accaaagatg tgcttgacgc aatggaagca 905101 gattcaaaca tttcattaaa gacgctccgt gtagacggag gagctgtaaa aaacaatttc 905161 ctaatgcagt tccaaggaga cctgttgaat gttcctgtgg agcgcccgga aattaatgaa 905221 acgactgcac ttggcgcggc ttatttggcg ggtatcgctg tgggattctg gaaggaccgt 905281 tctgaaatcg cgaaccagtg gaatctggat aaacggtttg agcctgaatt ggaagaagaa 905341 aaacgaaatg agctgtataa aggctggcaa aaagccgtga aagcagctat ggcttttaaa 905401 taaagtaata ctatggtata atggttacaa gttaataaga acggtcctga gatgaggaga 905461 gaccacagca ccaaagtgta agcatgcact ttggctgttg tggtctcttt ttctatttac 905521 cgtgacaaca aggaggaaac gtaatgatga atcatcaatt ttcaagtctt gaaagagatc 905581 gcatgctgac agacatgacg aaaaaaacat atgacctatt tattatcgga ggaggaatta 905641 caggagccgg aacagctctt gacgcggcat caaggggaat gaaggtcgca ctaagcgaaa 905701 tgcaggactt tgcggcggga acatcaagcc gatcaacgaa gctggtacat ggcggcttgc 905761 gctatttaaa acaatttgaa gtgaaaatgg tcgctgaggt aggaaaagag cgggcgattg 905821 tgtatgaaaa cggcccgcat gtcactacac cggaatggat gctgcttccg tttcataaag 905881 gcggcacatt cggttcattt acaacatcta ttgggttaag ggtttatgac ttccttgcag 905941 gtgtgaaaaa gtcagaacga agaagcatgc tttcagcaaa agaaacgctg caaaaagagc 906001 ctttggtgaa aaaagacggc ttaaaaggcg gcgggtacta tgtggaatac cgcactgacg 906061 atgcgagact gaccatcgaa gtcatgaagg aagcggttaa attcggggca gagcctgtga 906121 attactccaa agtgaaggag cttctttacg aaaaaggcaa agccgtcggc gtattaattg 906181 aagatgtgct gacaaagaaa gaatataaag tgtatgcgaa aaaaattgtc aatgctacag 906241 gcccttgggt cgatcagctc agagaaaaag accattcgaa aaacggaaag catttgcagc 906301 atacaaaagg cattcacctt gtatttgacc agtctgtctt tccgctgaaa caggctgtat 906361 atttcgatac acctgatggc cggatggtat ttgcgattcc tcgtgaaggc aaaacatacg 906421 tgggaacaac agacactgtt tacaaagagg cgctggagca tccgcggatg acaacggagg 906481 atcgtgatta tgtcatcaaa tcaatcaatt acatgttccc ggaactgaat atcactgcga 906541 atgacatcga atccagctgg gcggggctgc gtccgctgat tcatgaagaa ggcaaagatc 906601 cttctgaaat ttcacggaaa gacgagattt ggacatctga ctcaggcctg atcaccattg 906661 ccggcggaaa actgactgga tacagaaaaa tggcggagca catcgttgat cttgtccgtg 906721 atcgcttaaa agaagagggc gaaaaggatt ttggaccatg taaaacgaaa aacatgccaa 906781 tctctggcgg gcacgtcggc ggttcgaaaa atcttatgtc cttcgttacc gcgaaaacaa 906841 aagaaggaat tgcagccggt ttatcagaaa aagacgcaaa acagcttgcg atcagatacg 906901 gctctaacgt agatcgcgtc tttgaccggg tagaagcgct gaaagatgag gccgcgaaac 906961 gcaacattcc ggttcatatt cttgctgagg cagaatacag tatagaagaa gagatgactg 907021 caacccctgc tgacttcttt gtccgcagaa cgggacgttt attttttgat atcaattggg 907081 taagaacata taaagatgcc gttattgatt ttatgagcga gcgattccaa tgggatgagc 907141 aggcgaaaaa caaacataca gaaaacctca acaagctttt acacgatgcg gtcgtaccgc 907201 ttgagcaata aatcataacg ggctgtctgc agcccgttat ttctttttac gtgccgaaag 907261 ggggagatct caggttatca agtgacagag gcacccgctt catataaaat aatggcataa 907321 gctgatacat aggaggacga atatgacttg gagaaagagc tatgaacgct ggaaacagac 907381 agaacattta gatctggaat taaaagagcg ccttattgaa ttagagggag atgaacaggc 907441 ccttgaggac tgtttctata aagaccttga attcggtacc ggcggaatgc gcggggaaat 907501 cggcgccggg acaaatcgga tgaatattta cactgtgcgc aaagcatcgg ccgggtttgc 907561 ggcatacatc tcgaagcaag gtgaggaagc gaaaaaacgg ggcgttgtca ttgcttatga 907621 ttcccgccat aagtctccgg agttcgcgat ggaagcggca aaaacacttg cgacacaagg 907681 catccaaaca tacgtgtttg atgagcttcg cccgacgcca gagctgtcat tcgctgttag 907741 acagctgaac gcttatggtg gaattgtggt aacggcaagc cataacccgc ctgaatataa 907801 cggctacaaa gtatacgggg atgatggcgg ccagctgcct ccaaaggaag cggacatcgt 907861 cattgagcag gtaaacgcga ttgaaaatga gctgacgatc acagtggacg aagaaaataa 907921 gttaaaagaa aaaggcttaa tcaaaatcat cggtgaagat attgataaag tttatacaga 907981 aaaactgacg tccatttctg tacatcctga attatcggaa gaagtagatg taaaggttgt 908041 tttcacaccg ctgcatggaa ctgcaaataa accggtcaga cgcggtcttg aagcactcgg 908101 ctacaaaaat gtaacggttg tcaaagaaca ggaactgccg gattcaaact tctccactgt 908161 tacatcgccg aacccggaag agcatgcggc attcgaatat gccattaagc ttggggagga 908221 gcagaatgca gatattctca tcgcgacaga tcctgatgct gaccgcctcg gcatcgcggt 908281 gaaaaacgat caaggcaaat atacagtgct gacaggaaac caaaccggag cgttgctgct 908341 tcattacctg ctttctgaaa agaaaaaaca aggcatcctg cctgataacg gtgttgttct 908401 caaaacgatc gtcacaagcg aaatcggccg tgctgtagct tcttcattcg gccttgatac 908461 gattgatacg ctgacaggct ttaagtttat cggtgaaaag attaaggaat acgaagcatc 908521 aggccagtat accttccaat tcggttatga agagagctac ggttatttaa tcggggattt 908581 tgcccgcgat aaggacgcca ttcaggctgc gcttttggca gttgaagttt gcgcgttcta 908641 taaaaaacag ggaatgtcat tgtatgaggc gctcatcaat ctctttaacg aatatggttt 908701 ttatcgtgaa gggctgaaat ccctgacgct gaaaggcaaa caaggagcag agcaaattga 908761 agcgattctt gcttccttca gacaaaatcc gccgcagaaa atggcgggca aacaggttgt 908821 cacagcagaa gattacgctg taagcaaacg gacgcttctg actgaaagca aagaagaagc 908881 catcgacttg ccaaaatcaa atgtattgaa atacttcctg gaagacgggt cttggttctg 908941 tctccgtcct tctggaactg agccgaaggt taaattttat ttcgccgtaa aagggtcatc 909001 tttggaagac agtgaaaagc gacttgccgt cctttctgaa gatgtaatga agacggtgga 909061 tgaaattgtt gagtcaacag caaaataatt caagtatgag ctgggtcatt gtaaatgatc 909121 cggctttttc tttttctcat ccaaaagtct gaaagaaaat catcctacaa gtgaagcaat 909181 gaaatacaaa aaactggtat aatcttaaat acaagatcaa tgccggagtg agaaacgtga 909241 gcaaaacgag gatggaaaaa ttaaaaacgc tgaaaacgat tgcggaaacc ttaaatcaag 909301 ggcacgatat caaagcaaca ctggatgagg ttttaaaaga gttgctgagt ctgacaaacc 909361 ttcaatccgg atggattttt ctgatcgaag aagatgggtc ttatacgtta gcggccgacg 909421 cttatctgcc cccggcttta agccgcaagg aaaaagtgct gatgtgcgaa ggggagtgtt 909481 actgcctgac gaaattcaat aacggagggc ttagaaaagc tgcaaatatc atgaactgca 909541 aacgcatcga atcagcagaa aacctgcatt gttttgacac agaagggatt acgcatcatg 909601 caactgtgcc tttagaagac ggggacagaa gattcggatt gttaaatgta gcggcggccg 909661 gaaaaaccat gtttgatgag gaagagctgc atttactcga gtctgtcgcc tttcagatcg 909721 gaacggcaat ccagcgtatg aggctttctg aatatcaaca aaaaaatgct cttttaatgg 909781 agcgtaaccg cctcgctcag gagcttcacg attcagtcaa tcaaatgctg ttttccgtca 909841 gtttaactgc caaagctgcg aagacactaa caaaagatga aaatttacag cagatgattg 909901 atttcatcca aaacctatca caggacgcgc tcgcagaaat gaaagcgtta atttggcagc 909961 ttcgccccgg aggattggaa aaagggctgg ctgaagccat taaaagctat ggtgcgctca 910021 ttggattgaa gatcattttt acacaaaaag gctgtcctgt tctgactgat gagcaggagc 910081 atatgctatg gcgtgtcgta caggaagctt taaataactg caaaaagcat gccggaacgg 910141 atacggcgta tgttagtctg actgcttctt tgtgccatgc ggagctggat atcatcgatc 910201 atggggcagg atttcgctat gaagcgcatg ccggtctgcc ttcacttggc ataaaaggta 910261 tgaaagagcg agcggaaaaa gccggagcta agttttggat tgagtcagcg cttggaactg 910321 gaacaaagct gtccatcagg cttccgctaa aaagccgaaa aggaggggcg gtatgaaaat 910381 tgtcattgct gatgatcatc atgttgtcag aaagggtctg cgttttttct ttgccaccca 910441 ggatgatatt gaagtcgtcg gagaagctgc aactggatta gaagccctcc gtgtcatcga 910501 agagacaaag ccggatcttg tgctaatgga tttgtctatg cccgagatgg acggcattca 910561 agccattaaa aaagcaatac agcaatttcc ggatacgaat atcattgtgc tgacgagcta 910621 ctctgatcag gagcacgtca tccccgcgct tcaggcaggc gcgaaggcgt atcaattaaa 910681 ggatacggag cccgaggaat tggtgaaaac acgacaagtg catggtggcg aatacaagct 910741 ttctacagct attatgcccc atgtgctgac acatatgaaa aatcagcacg acccggaaaa 910801 agaaaaatac tatcaattaa ctagaaggga aaaagacgtt ctgactgaaa tagcgaacgg 910861 gaaaagcaat aaagaaatcg cagcagcctt gtttatttca gaaaaaacag taaaaaccca 910921 tgtatcgaat cttttagcaa aacttgaagt ggccgatcgc acgcaagcag cgcttttcgc 910981 agtgaaatat aacctgaatg gagagatctc aaaatgaaca tgttagtcat aaatggcacg 911041 ccaagaaaac atggcagaac aagaattgca gcatcctata ttgcagctct gtatcacacg 911101 gatttgattg atctaagcga gtttgtattg cccgttttta acggtgaagc ggaacaatct 911161 gaactgttga aagtacagga gcttaagcaa cgcgttacga aagcggatgc gattgtatta 911221 ttatcgcctg aatatcacag cggcatgagc ggcgctttaa aaaatgcctt ggattttcta 911281 agcagcgaac aattcaaata taagcccgtt gcattattgg cagtagcggg aggcggaaaa 911341 ggcggcatca atgcgctgaa caatatgaga actgtgatgc ggggtgtcta cgccaatgtc 911401 attccgaagc agctggtgct tgatccggtg catattgatg ttgaaaatgc tacagtggct 911461 gaaaacatta aggaaagcat aaaagagctt gtcgaagaac tcagcatgtt cgcaaaagca 911521 ggaaatcccg gcgtctaaac gccgggattt gtttatgtga gaagggctat ttgatcttca 911581 taagtcagct ctgtggcatg atcaatatat cggagaaggg aatacagcat cttttctaaa 911641 acggcgtaat cctgttcaaa atgatacgca tgcagaaaat gctcaattcg ttttgataac 911701 aaatcgtcct ctgtacgcac cattaaaatt aataaattat cccattgaga acgatgggtg 911761 taataaagcg ctttatcgta atcggcataa tccatgaatc gcttctcctt tcttgggtga 911821 gaagttcatg attagtttat gccgcatcct ctgttattga cggggcaaaa cttgccgtct 911881 gcgtcagtaa aggggtagca atatgaggga gacataaaat caaaatgcct gaatgaagat 911941 atcgcttttg gtaaacctat gagggaatat attctgggta caggagactg aaaaaatgaa 912001 atccctgccg tataccatcg cacttctttt ttgcggattg attatcgtgt caatggctgc 912061 aaaaggtcat tcaacggaca cagacgagtc cgttcaaaag tgggaacagc ttgcctggag 912121 caaaattcag gatgaatata agggcgcttc attttctgat tatgcttata tggggcgtac 912181 agaggtgaat gatcagcaga ctaaagatgt ctttcgggtg acagtcagac agaaagatga 912241 cactttttct gttcgggccg aagtctattt tcatccggtg acaaatcata tgatcagcat 912301 caacgtcttt aggctctaat aaaaaactgt acagccgtta aggccgcaca gtttctgttt 912361 ttagaaatat cgttttgcac cgagatagcg ctgtttccag taagagttgt tcatattgga 912421 aatgacaact ccggaatcgt tggcatttat gaattccccg ttgcctaggt aaattccgac 912481 gtgggaaggg ccggctttat atgttgaaaa gaaaacgaaa tctccgacag caggctggct 912541 aactgatttc attgtgttcc aatatcccgc tgccgttaat ctagatacgg atgtgacttt 912601 gttcagtaca tagtaaatga atccgctgca gtcaaacccg gacggtgtcg tgcctcccca 912661 gcgatacgga accccaagct gcgctttagc ggccgaaatc attgtgttaa tcttcgcact 912721 cgttgagctg gtggtgtttg aagaaccgga tgaagacgat gatgaagctt ttccggaaat 912781 gaccagcttt tggccaacct gcaagacatc cgtttttaaa ttgtttttct cacgaatctg 912841 ctgagctgtt acattaaatt tttgagcaat cacccataag gaatcaccgc ttttcaccgt 912901 gtatgtagtc gtcgtgccgg agcttgcatt tgacgaagaa gacgacgatg atgaagagcc 912961 tgaagatgct ttacctgtca gcttcaatac ttgtccaacg taaagcacat ctgatttcag 913021 attgttgata tttcggattt gctgtacagt caggttatag ttgtttgcga ttttccaaag 913081 tgaatcaccg cttttaacgg tatatttagt tgttgctgaa gtttggttcg atttggatga 913141 attgtcttta gaagacgtat cagagccgct tgattttgtt ttcaacacct gattcacgta 913201 aatggtgtct gattttaagt tgttcaagac cttcaattca gcgatggaca tattgacttt 913261 gtttgcaatt ttccaaagtg aatctccaag ctgcacctta tatgttcccg tagaagatga 913321 agaacttgaa ctcttattag aactgctttt tgaactggag cttgaactct tattagagtt 913381 gcttttttta ctggaactag agcttgaaga aacagtaccg gacaccttta atttctgccc 913441 agcacgaatt aaatcgctgc ttagtccgtt taattttttc agttcctgca ccgtcatttt 913501 aaactcattt gcgatcagcc aaagtgaatc tccgcttttc actgtgtaaa cagaacttcc 913561 gctcttcttg gttgttgagc ttgaagtaga tgaagaagtg ctggatttgc tgcctggaat 913621 agtaagcgtc tggccgatcg acagaacagt agtcgaaaga tgattggcgg atgtgagggc 913681 cgccacactt gtgttatagg tttgggccag tttccataaa gaatctccgc ttttgacctt 913741 aatcgttgct gcttcagctg gtgtcactac taaagttgtg ccgacaatcg cagatgctgt 913801 cagccctgct gctaatttct ttttcatctt agctctcctt tttcccccaa tgattttgca 913861 tttgctgttt cttttttata tcggcacatt tgtctcatcg ttttgccttt ttataaaaat 913921 agccaaatta tcttaacaat aagggggaaa aagggcataa aaaaagaagg aatcttaatc 913981 tattccttca tttttaaaag cttcatgata tcttctttgt ttttgacgag gtcgcgcagt 914041 gtgtatttgt ctaaaactgc gaggtaggct aaaagcgctt cattcagcac atgttttaag 914101 ccgcaaaccg gggaaataac acagagattc ttgttcgcat caaaacattc aacaatatta 914161 aaatcgtcct ccgtttttct gacaacctca ccgatgttga tgtcttcagg gtccatgcct 914221 aatcgtatgc cgccgccccg tccgcgtatc gtttctacgt agccgagctg gccgagcctg 914281 tatatgactt tcatgagatg attttttgaa atagaatacg tttcggcaat ctgttttata 914341 tttgaaagtt ctccgggacg ctctgcagcc agaaaaatca acactcttaa tgaataatct 914401 gtataattgg ttaacttcat aataagacct cagaataaga cattttctat atcttatcat 914461 aatcgattga aaaatgaaaa aaaaggaatt aaaaaacatg cacccagctg ggtgcatgtt 914521 ttttgcttac atgtcattcg gcggattttg gtttttacgg tttttttcga tttctgtgtt 914581 ttgcattttg cgttcaaatg tagacagata acgtgatgca aaatccttac cgccaaggcc 914641 gaaggataaa ccaaaagcaa gtgcgaagcc gctaagaacg atgatgaacg cggaattgac 914701 gattgtcgca gcgacaccca gctgatccag ggccataaag aaagcaagtg cgataatcgt 914761 atatttagca ataggcgcta aagacttgaa ttcctgacct tttatcatgc ttgcgagcac 914821 ttttctcacc aattctcctg cgtaaaggcc gagtccgaga atgaatactg cgacaaggac 914881 attcggcaga tacgcgatga tgccggtggc aatttctacg aggaagtgca gccgaacaat 914941 ttgaagcgcc tcagctgtaa agagcagaat gacaatgatt tgcgcaatca taccgacaac 915001 ttgagacaag gacagctttg caggcgttcc ggcttccatg cccattttcc ctaagacaga 915061 atcaaagcct gcgcgatgga gcagtccgga caccatggat ttcacccatt ttcctgccca 915121 gatacccgct aatacaagca cgatggcaat catgatgttc ggaagcatgt ttaaaatcgt 915181 attcagcata gagacagctg gttttgaaat gccggcgaca tccagctgat caagcgctga 915241 aatgaccacc ggaatcataa tgagcacata agcgattgtt ccgatgactg ctgaaaggct 915301 tgtgtctttt aagtaaattg ataaacccat acgtgccgcg aatctttcgg tgccgatgct 915361 tgcaaggaaa ttcgtaatga tatcacggac aaggcgggca acaagccatc cgattaatac 915421 gataagcgcc gctgcaaata atttcggcag aaaagcgagc acgctttcca tcatatttgt 915481 aaaaggacct gaaatgccgc tgattttcaa agaagataag acccctggca gaaaaacaag 915541 cagcacgaga taaaagacaa tttgtgaagc ggtattgaca gcctggtgaa tatcttttcc 915601 ttcagacacc aaattccact tgcgcagttt gtcactcgtg ttcagcttca tcccgatttt 915661 tttgacaagg aagctcaaaa cagaagctgc agcccatcct aacagcagaa tgagtccggc 915721 tttcagcacg cttgggatcg cagctgcaat cgccgaaagc atactgacaa acggcgatgc 915781 cactgttgtc aggtgcaaaa tgttaaagaa taaaataaag acgatgatca gtgcgataaa 915841 ataaacgacc ttgcttatga ctttttccga ggaatagcgt gaaggctttt tcccagcaaa 915901 gagcttgtcg tcgatttttg ttttgctgag tcctttgtat accgcttttt caatgatttt 915961 agcaatagcc cagccgatta ataagacgag taaagcaatg attacgtttg gcagcttact 916021 gagataagaa gaaaacacgt ctgctacatt caattggtat cgctcctttt tcgtagtatg 916081 gtgtgtgttt acccacttat ccaataagca aacagatgaa tgtgccgggg gaattttttc 916141 ttgcccgagt gagactatca tcttttgtct ggcgggctca tacattatag ataagtccaa 916201 gtagggggga ttcggttgaa cgcggaggag aagaagggat tacagcgggc aattgaggaa 916261 attaccgaaa ttgcaaaagg attcggcctt gatttctacc cgatgagata tgaaatctgc 916321 ccggctgaaa ttatttatac atttggcgcg tacgggatgc cgacaagatt cagccactgg 916381 agcttcggca agcagtttca caagatgaag ctgcactatg atctagggtt aagtaagatc 916441 tatgagctgg tcattaactc agatccatgc tacgcttttt tgctggacag caactcactg 916501 atccaaaata aattgattgt cgcacacgtt cttgctcatt gcgatttctt caaaaacaac 916561 tgccgtttcc aaaacacgaa gcgcgatatg gtggaaagca tggcggcaac agctgaacgg 916621 ataaaacact atgaacaggt tcacgggata aaagaagtcg aatctttttt agatgcaatc 916681 ctttcgattc aggagcatat cgatccgtcg ttggtccgac caaagctcca atggagtgtg 916741 gatgatgagg aagaggagat tgaagaggca gccacgcctt acgatgatct atggtcttta 916801 gatgaaaaga aaccgaaaaa acaagtgaaa aaatcgaaaa aaccgttccc gccgcggcct 916861 gaaaaagata tcctgctttt tatcgaggag cattcccggg agctggagcc atggcagcgt 916921 gatatattaa cgatgatgag agaggaaatg ctttatttct ggcctcagct ggaaaccaag 916981 attatgaatg agggctgggc ttcctattgg caccagagaa ttatacgtga gcttgattta 917041 acctctgatg aagcgatcga gttcgccaag ctgaatgcag gtgtcgttca gccgtccaaa 917101 acaggcatta atccttatta tttagggctg aaaatatttg aagacattga aaagaggtac 917161 aacaacccga cggaggaaat gaagaaaatg ggcgtgcagc ctgactccgg ccgggagaaa 917221 atgtttgagg tcagggagat tgaatccgat atctctttca tccgcaatta tttaaccaaa 917281 gaattagtca tgcgcgagga tctttatttg tttcaaaaac agggccgaga ttataaaatc 917341 atcgataaac agtggaagtc ggtgcgcgac cagctcgtaa gcatgcgggt aaatggcggt 917401 tttccatatt tgacagtaaa cgacggcgat tatatgaaaa ataacgaact ctatattaag 917461 cattggtatg agggcataga gttggatttg aaatatttgg agaaagtgct tccttattta 917521 ttccagcttt ggggaagaag cgtgcacatt gagtctgtgc ttgaggataa ggaagtcatg 917581 ttttcgtacg acggaaaagg tgttcaccgc agatatttat aaaaaagagg atgcagcgtt 917641 ctgcatcctt tttattttcc agtttttaaa atcttaaata tgatgtttgc ctggtccgta 917701 ttgttaatca atccgcggaa tttttctttt ccggggccgt acgcgtatac cggtacttct 917761 tcgccggtat gatcggtact cgtccatccg ctgttggagc gggtattaaa aatcttgatg 917821 atggctttgg aggccccttt gcttttgtca gcctgtgcag ctgcttcaac gcttttgatt 917881 tcttcagatg tgactttcag attggcatag cgggcgagca catctttaac cggcttgcct 917941 tcactgattt ttttggccat gaattcaggt gttttcttag cggagagaat cggttctgcg 918001 tgccaattct tttccccgtt tgcgccaatg gtaaagccgc cggttgtatg gtcagcagtt 918061 gcaatcacaa gtgtatgttt gtcttttttc gcaaattcaa tcgcggcttt ataggcctgt 918121 tcaaaatctt taacctcgct catggctcct actgtatcat tgtcatgggc cgcccagtca 918181 atctggctcc cttcgaccat caagaaaaat ccttttttat tttggttcag gcgatcaatt 918241 gctgaaaccg tcatgtcttt gagagacggt gttttactgt cacggtcgag cgctttagca 918301 agccctccat ctgcgaaaag cccgagcacc tgctgatctt tatttttttt caatgcttgt 918361 ttagttgtca catagctgta gccggcttgt ttgaattcct ttgtcaagtt tctgtccttg 918421 cggttaaaat aagattttcc gccgccgagc agcacgtcta ttttatgttt gccttttatc 918481 ttgtcatcca tatagctgtt ggcgatttgg tccatgtttt tccgtgattc attgtgggcg 918541 ccatatgcgg ctggagtggc gtggttaatt tcagacgtgg cgacaagccc tgttgacttg 918601 ccttgctgtt tggcctcttc aagtacagat ttcacttttt ttccgttttt atcgacgcca 918661 attgcattgt tatatgtctt aacgcctgtc gctaatgctg ttccggctgc tgctgaatct 918721 gtaatattat agtcagggtc atccggatgc gtcatcatca tgcctgtcag gttccggtca 918781 aattctgtta acttcgggtt attcggtgtg tcaccgttat ttttcatgga acggtaggct 918841 cttatgtaag gcgtccccat gccgtcgcct atcatcacaa tgacatttct gatctcagct 918901 ttgtcttgtt ttttggcgct ggccttttct gtttgctgaa gctcagctcc ggcaaagatt 918961 ccagctgtaa ggacagaaac agcggcgatt ggcagaagtt ttgatttcat attttgaaac 919021 aaactcattt ttttcatgcc tcctttaatg tattccgttt atcatgttag ggaaactttg 919081 ttaaatgcgg ctgttgatca tgtaaacaat aagtaaagcc ttgtaaggaa atgaaaaaac 919141 gcttttcgtt atcttgcctt atttgatgta aagcattcat ttttcagaaa aatctttacc 919201 tctctgtctt tgcatgatat gtttgtttaa ataaaaaaac tgcggataac cacagctctc 919261 ctcgaatata ctttatcact catttttccg atatatgagc cgaccccgaa agtttttcat 919321 ttatttcctt tatgttgaaa aacatcccat aaaacatgac aaaagcactc gttttttgtc 919381 acctttgcaa tgaaaatgaa atatttaata cccttaaaaa ctttttttta gaacgaataa 919441 ttaagaaatt tgtcacatga agtcaagact atttctgatg ggaatctatc cttataatag 919501 aaatcaataa gattaattta aaaaaagaga tacatatata tagagttaac atttggggag 919561 gaaaatatga aaaagcaaat cattacagct acgacagcag ttgttttagg atcgacgtta 919621 tttgcaggag cggcatctgc acaaagcatt aaggtgaaaa aaggcgacac gttatgggat 919681 ctttcaagaa aatacgacac aacgatcagt aaaattaaat cagagaacca ccttcgttca 919741 gacattattt atgtgggaca aactttatcg attaacggca aatctacaag ttcaaaaagc 919801 agcagttctt cttcctcttc ttctacatac aaagtaaaga gcggggacag cctttggaaa 919861 atttcaaaaa aatacggcat gacaatcaat gaactgaaga agctgaatgg cttaaaatca 919921 gatttgcttc gtgttggaca agtcctgaaa ctgaaaggtt caactagttc aagcagctcc 919981 agctcatcaa aagtgtcatc gtcttcaact tctacttata aagtgaagag cggagacagc 920041 ctttctaaaa ttgcgagcaa atacggcact acggttagca aattaaaaag cttaaacggc 920101 ttaaaatcag atgtaatcta tgtcaaccaa gtattgaagg tgaaaggaac aagcacaagc 920161 agctcaaaac ctgcttcatc ttcatcgtct tcaagcagca aaacgtcatc tacatcactt 920221 aatgtgagca agctggtttc tgatgcaaaa gcgttagtcg gaacgccata taaatggggc 920281 ggaacgacaa cttcaggctt tgactgcagc ggattcattt ggtacgtact gaataaacaa 920341 acaagtgtgg gcagaacaag cactgcagga tactggagtt ctatgaagag cattgccagc 920401 ccgtctgttg gtgatttcgt cttcttcaca acatataaat ccggcccttc tcacatgggg 920461 atttacattg gaaacaacag tttcattcat gcaggatctg acggcgtaca aatcagcagc 920521 ctgaacaaca gctactggaa gcctcgttac ctcggtgcga aaagattcta atttttagag 920581 aaaacccgtt cattggaacg ggtttttttc attagacgga gcacaggcgt tttggttgct 920641 cctaaaaatg aaaatgtgat aaaaaatcca agaacttttt ttctttctta ttttcataaa 920701 gggcaatcgc gtaagcgccg gcatagggca gctgtacaga ctgataagga attctgatca 920761 tctgtttctc tgctaactca cgctttactg tagataaagg cagaaatgaa actccgagtc 920821 cttccttgat aaaccgtttc gttatatgtg tttgagtgac cttcattgtt ctcacaaatg 920881 gaaatgtcat tctgacttga cggagcaagt cgtcccagta atcaggatga ttgtgggtca 920941 aaagcaggta ttgttcgagc acctctttgg catcaatttc gttgtcttct atgaaacgct 921001 tatcgggcgg ggcaacaagg acgacagggt ctttgtataa gcagtggcag cttaaagaag 921061 aagactgtac ctttaaacag cttagtccga tatctgcttc cccggcttta atcagtgacg 921121 cgatttccgc tgattcgaaa atcgtaaccg ccatttctgt ttccgtattc attgctgtgt 921181 accgcttcat gacagaagga agcactgtat ctgcaataag cggagaaacc gcgagctgta 921241 aggtttgaga gtagccttgt ctcactctgt gaagctctgc catgctgttt tcataatcat 921301 caagaagcct gagcgcatac ggcaaatacg ccctgccttc atcagtcagc tggatttgcc 921361 tgcctttacg ctcgaacagc ttgcagctga tttctttttc taattgcttg atatgtacgg 921421 tcacagtagg ctgagataag aaaagcgttt ccgccgtttt tcggaagttc tcatattttg 921481 cagcggtcac aaaggtgtga agccatttga aatccatttc tattctccct ctgattaata 921541 tttttaatta attcccttta aaatattgat tattttttaa atattatatt tactataata 921601 acagaaaagg atagggggaa tacaaatggt acattacgga ttaaagggaa ttacatgtgt 921661 agaaacatcc atcagccata ttgatggtga aaaagggcgt ctgatttaca gaggacatca 921721 tgcaaaagac atcgcactga atcacagctt tgaagaagcg gcttatttga ttttatttgg 921781 aaaactgcct tcaactgaag aattgcaggt atttaaagat aagctggctg cggaacggaa 921841 tcttccggaa catattgagc gcttgattca atcactgcca aacaacatgg acgatatgtc 921901 ggtgctgaga acggttgttt cagcattggg ggaaaatacg tacacattcc atccgaaaac 921961 agaggaagca atccggctga ttgcaatcac gccttctatc attgcataca gaaaaagatg 922021 gacgcgcggt gaacaagcaa ttgcaccttc ttcccagtac ggacatgtcg aaaactacta 922081 ttatatgctc acaggtgaac agccttcaga ggcaaaaaag aaagcgcttg aaacctatat 922141 gattctggcc acggagcacg gcatgaacgc atcgactttt tcggcacgag tcacgttatc 922201 tacagagagt gatttagtgt cagccgtcac ggctgctctc ggtacgatga aaggtccgct 922261 gcacggaggt gctccttctg cggtgacaaa aatgcttgaa gacattggag aaaaggaaca 922321 tgctgaagca tatctgaaag aaaaactcga aaaaggagag cgcttgatgg gattcggcca 922381 cagggtgtac aaaacaaaag acccgcgggc agaagctttg agacagaaag cagaagaggt 922441 ggccggcaat gaccgtgatc ttgatcttgc gctgcatgta gaagcagaag cgattcgttt 922501 gctagaaatc tacaaaccgg gacgaaagct gtacacaaat gttgaatttt acgcagctgc 922561 agtgatgagg gccatcgatt ttgacgatga attgtttact ccgacctttt cagcaagccg 922621 aatggtaggg tggtgcgccc atgtactgga acaggcagaa aacaacatga ttttccgccc 922681 gtcagcgcaa tataccggtg ccattcccga ggaagttctt tcataacata ttttggcgtt 922741 tattcatttc tgtcgtgtgg taacgttcag tatcaaccac atgtctagga gtgatgaatg 922801 tgaacccaat ggacagacaa acagaaggac aagaaccgca gcatcaggac agacagccgg 922861 gcattgagtc aaaaatgaat ccgctgccgc tgtcagagga cgaggattat cgaggaagcg 922921 gaaaactgaa aggaaaagtt gcgatcatta ctggaggcga cagcggaata gggagagcag 922981 cagctattgc ctttgctaaa gagggggctg atatctccat tctatactta gacgagcatt 923041 cggacgcaga ggaaacacgc aaacggatcg aaaaggagaa tgtccgctgc ctgcttatcc 923101 cgggagatgt tggggacgag aaccattgtg aacaagctgt gcagcaaaca gtggaccatt 923161 ttggtaaact cgatatctta gtgaacaacg ccgctgaaca gcatccccag gacagcattc 923221 tcaatatttc aacagaacag ctggaaaaaa cctttcgcac aaatattttt tccatgtttc 923281 atatgacgaa gaaagctttg cctcacctgc aagaggggtg tgccattatt aatacgacat 923341 cgattaccgc ttatgaaggg gatacggcgt taattgatta ttccagcaca aagggtgcga 923401 ttgtttcctt tacgcgttcc atggcgaagt cgcttgcaga taaaggcatc agagtgaatg 923461 cggtggcgcc cggtccgatt tggacaccgc ttattccggc gacattccct gaggaaaaag 923521 tgaaacagca cggcttggat accccaatgg gaagaccggg acagccggtt gagcatgcag 923581 gcgcctatgt tctgctggcg tctgacgaat cttcctatat gacagggcag accattcatg 923641 tgaatggcgg ccgttttatt tcaacgtaat caacgaaaaa ccagctcaag agctggtttt 923701 ttgtgtggtg aaaaatttca aaataaaaaa tttgtcgatt tttctaacaa ttttgttttc 923761 atttttgcaa ttttatatat aatattgagt aggagaaagg aatgattcgc gaccagtaca 923821 aatatagtag aaaaaaaaga ataatgacca ttgttactca tgaattcaga aaattcaaat 923881 aaaatatata aaaatagatg atcgggagtt gaaggggaat gaaagggagc gtttttagga 923941 agaaaagcat tcaggattta atcgctgcga cgagcgggga aaagtcttta aaaagagaat 924001 taggggcatt tgatttaacg ttgcttggaa tcggcgccat tattggcaca gggatttttg 924061 ttctgacggg aacaggcgca gtcacggccg gtcccgggct gacgatttca tttgttgtgg 924121 cggcgttggc ttgtttattc gccgccctgt cttacgcgga atttgcgtca agtgtgcctg 924181 tttcaggttc ggtgtataca ttcacttatg cgacattggg agagcttatg gcctttatta 924241 tcgggtggga tttaatttta gaatacatgc tggcggtaag tgcagtgtcg gtcggctggt 924301 ctggttattt ccaatcgttt ttatcagggc ttggcattca tcttccggtt gctttaacag 924361 cggcaccggg cgcagtgaaa ggcaccttta ccctgtttaa tcttcctgca ttcgtcattg 924421 taatggcgat cacatatttg ctttatttag gcatcaaaga atcaaaaaga gtcaacaata 924481 tcatggttat cttgaagata ctggttgttc tgctgtttat cgcggtggca gccgtttacg 924541 tgaagccgca caactggcag ccgtttatgc caatgggctt tggcggcgtg ttcagtgcag 924601 cggcgctcgt attctttgct tttatcggat ttgacgctgt atcctctgct gcggaagaaa 924661 cgaaaaatcc cgcgaaggat ctgcctaaag gcattatttt ctctttactg gtctgcacga 924721 ttttatatgt caccgtatca gccatcatga ctggggttat cccgtttgct caatttgcgg 924781 gtgtggatca tccggtttct cttgttcttc aaagcgcagg gcaaaattgg gtggcaggca 924841 tcattgatat tggcgccgtg ttgggaatga caacagttat gctcgtgatg ctttacgggc 924901 agacccgcgt catgtttgcc atgtcgcgtg acggacttgt gccgggttca ctttctaaag 924961 tgcatccaaa gcacaaaaca ccttatgtag ccacttggtt tttcggaacg atgtcggcgc 925021 ttctcggctc acttgttccg ctggatgaac ttgcaaagct ggtgaacatc gggacgttgt 925081 cggcatttgt cctgatttct gtggcagtta tcgttttgag aaagaaacag cctgatcttc 925141 cgagagcttt taaatgcccg ggagttcccg tgatcccagg cctggcgatt ctgttctgcc 925201 tgttcttgat tttaaatctg ggatgggtga cgattgtccg cttcctagtg tggctgttaa 925261 tcggcttggt aatctatttc ctgtattcaa gaaagcattc aaaattaaat caataacctt 925321 ttgataaaga gagcggccat acaggccgcc tcttttctgt tcttggcaaa tgaatctata 925381 gaaatgaaga caaaaataag agataatata ggctggaaag gaagtgacgt ttattgtctg 925441 agcaaaaacc agtccaatgg gcttcgaaaa ttggtttcgt catggcagcg gccggctcgg 925501 ctatcggctt gggcgcgatt tggaagttcc cttacgtagc ggggaccaat gggggaggag 925561 ccttttttct tatcttcgtg ttatttacca tcctcttagg ctatccgctt ttggtggggg 925621 aatttatttt tggaagacgg aaccagacga atgccattga tgcatataaa aaagaagcgc 925681 cgcgatcagc ttggtttctt acggggtgga tcggcgtagc ggcgtgtttc ttagtgctgt 925741 cgttttacag tgtaatcggg ggatggattt tgctgtatat cgtgaaaaca gcgtcaggat 925801 cactgtccgg gctttctcaa gcacagtatg gcgctctttt tgcttctatt atccaaaatc 925861 cggtgcagac gctcgcggct cagcttgtct ttatggcact gactgtactc gttgtcgcaa 925921 gaggggttca aaaagggatt gaacgggtaa gcgcggtgat gatgccgatt ttgtttttat 925981 tgtttattct gctcgttctt cggtctctta cgcttaatgg tgcaatggaa ggcgtaaagt 926041 ttctgcttgt gcctcatttc ggcgatctga ctccggaatc catattattc gcgctgggac 926101 aggccttctt tacgttaaca ctgggggttt cggtgatggt gacctacagc tcctatttgc 926161 cgaaaacaca aaatatccct cgttcggcag cctccattgt cttgatgaat atcattgtga 926221 cactcttggc aggtttggct atttttccgg cggttttctc attcggtttt cagccaaatg 926281 aaggaccgac attgctgttt acagtgcttc cggccgtttt tgaacagctt ccgttcggca 926341 cattgttttt tatcggcttt ctcgttgcat ttttatttgc agccttaacc tcagcatttt 926401 cgatggttga aattatcgtt gccacaatcg gaaaagggga cgaaaagaag agaaaaaaac 926461 tgtcatggac gagcgggctt ttgatctttt tggtcggaat cccatgctgc ttgtcttatg 926521 gcgttttgag tgatgtgcac ctatttggca aaacgttttt tgatattgcc gattttaccg 926581 tcagcaatgt tttgatgcct tcaggcgctc tgttaatttc tctatttatc ccgctgaaaa 926641 tttcgaaaag cgaactcttg gctgaaatgc gaaatggatc aaatgcaggt aaagcattct 926701 tttacacatg gttttatttg cttcgtttta tcgtgccgct tgccattatt atcgtgttct 926761 taaatttaat cggaatttta tcattttaaa aaacaggctc cgtttccggg gcctgttttt 926821 tatttaataa gatgatatca acggtgccca tgccgttttc agtttttgga tgccgagcct 926881 gatgtcctct tctgacaaac cgccataacc gattaagaca gaagtaaaag gcgtctgttc 926941 tatatatgag ggagacacgg gatagagggt tacaccgtgg tcagcggctg cttgtattgc 927001 ttcttcctca cttgctggaa acaaaaggcg cagcagaatg tgaagccccg agttcttacc 927061 gagaatctca acggtgtttc ccagttcaga gcgaatggct tctaacagga cagcgtgttt 927121 ttttcggtat aagcttctca ttctatttat gtgtttttgc cactctccgg tttcgatgaa 927181 gtctgccagt gccaattgcg agtgggcaga aacggtctgc ttcattaact gaacattgtt 927241 ttggatcggt tccatgagtt cagggggcac aatcatgaag ctgagccgca aggaaggcag 927301 aagtgacttt gaaaaagtgc ccagatatat gactctgcca ttcggatcaa gaccctgtaa 927361 agacggaatg ggatggccgc tgtagcgaaa ttctccatcg taatcatctt ctataatgaa 927421 tgaatttgtt tctgccgccc atgccagcag ctcctgtctg cgggtaatcg tcataatggt 927481 cccaatcgga aactgatgcg aaggagtcgt atacatgaga taaggattct gacggtagag 927541 ctcatccggc aggacgcctt ctgcatcaga acaaatcgga gtgacatcca tgtgatttgc 927601 ttcaaacatc cttcttgaac ggtgaaagcc cggttcttca aagccgattt ttgtacctgg 927661 ctttagcgaa aggcaaagat tttgcagaag cacggtggtt cctgcgccga tgataatctg 927721 gccgggttca caatttactc cccgagacag cctgacgaat cgggcaatca tgtgcctgag 927781 ttcgtattct ccttgagggt cgccagaggt gtgaaacgat ccggaatagc gatcaagact 927841 ttttactatg ctttttctcc atgcgttaaa gggaaagagg gtcggatcaa cgctgccctg 927901 atggaagtca atagcaggtg cgtttttttg atgtaatccc ggctgtacag actgctgaaa 927961 atggtcagga gctgtcggga atcctggttc tacttccgcc gcgaaccagc cgattttcgg 928021 cttgcttttg acatagccct cagcagttaa ttgctcataa gctcgttcta tagttgccgt 928081 gctgacatcg agcaagctgg agagcctgcg ttttgacgga agtcttgttc cctttgtgat 928141 tcgcgcatgt gaaatttctt gtttaaaaaa ggtataaagc tgttcataca gcggtgtttt 928201 gctcttttta tcaagaaacg gcgtaatatc catctcatgt ctcctttgta gctggcatgg 928261 tcattttttc tgatattggc tatttggcaa atgccattta ttagctatga tcattgtaac 928321 gaaaggaaag gggattgaga agatgatcca tatgaaacaa ttaacctcga aagaagaatg 928381 ggctgagtcg tatccgatta tgagtgaatt gagaacagaa ctggatatag agacgtattt 928441 acaaaggctt gaagcctgtg tgcagaaaga atcgtatatg ctgtttgcct tatatgaaaa 928501 tacagcaatc agagcgctgt gcggggctct gccgagagtt tccattcata aaggagagca 928561 cttgtggatt gcggatcttg ttacaacggc accttgccga tcaaagggat acggcaaaat 928621 gcttttggat tatgcctcag actgggcgag aaaagccgga ctcggttttg tcagtctttc 928681 atctggcctt cagcgtaaag acgcacatcg attttataca gataaaatgg gttttactat 928741 agaaagttat ttgttccgaa aaccggtata acgaaaaaag acgcctgaaa aggcgtcttt 928801 tttaaaagcc aaactgtaaa ttcgtatcta cagatacaat ggtatacaca caaataatca 928861 caaagagatt aaggatgacg ccgagcaggc ctggacctgt gcgccctctc ttgatgaaga 928921 gttcaacaac gccgaacgga acggcagcca tggcgaacgg aagcatttga taggaataaa 928981 acgtgacgtt gctgataatg gccaaattca gcaacagcag ggacagaacc gctgtcccga 929041 cagagatcca gccgaataca ttgtgttctt taaaaattct taccagttcc ataattccac 929101 ctcgccgaca ttcgctgatt ttacagattt atttttcagc atgcgctgga tttccttggt 929161 tggccctgta acgaccgaac cgtatacatt gacaccgttt ttctctacat aatctaatcg 929221 gttatctaca ttcaggtctt tccgttttga aatgacctga gcccattttt cgtgtttgga 929281 catgaatttc agggcgttga taaactgatc gccattcgac ttgccttttg tattaagggc 929341 ggccaagaac tttgaatcct ttccaggata gccaagaggt tctgtggaag ctgtcttatt 929401 tgtgtttttc tctgtttcga ttgcgttcca caaaaagctc acatcatagc ctttgaattt 929461 gttatacacg tcttttgtcg gatatgcacg gtcatatgaa aggtagacct ctgataccgt 929521 tccttcaggc aatgtgctta acgttttttc tgcttttgcg gtcgtttgtt cagacttgtt 929581 tgaaggatgt gtaaagtaat ggccggtttt attcacttct aagtcatagt agtttactgc 929641 cggcgctttt actttgttat aaaacatttc aacccgttca ttccctacgg cagccgtctt 929701 cgtgccaatc tgcttttgca gcgggaattc cgtattcatt ccaaatagct tcacttggct 929761 tttcagtccg gaagtatcaa caagaacatt cggcatggtc agggctacag tgactgcggc 929821 agtttccata aactcattgc cggtgctgtg ttttccaccc attccgtaat agaggtagct 929881 tcccagcgta caaagcggca aaatcatcaa tgtcgaaatg acggcaagca cagaaattcg 929941 caaataagac ttgcgtttgc cgtaggctaa aatcgctttt tgtttttcag gactgatgct 930001 gagatcccaa tcgttatcgt cctctagttc gctgtcaatc agttcctgat atacttcaag 930061 cttctcgagt tcttcctcaa atgcagtcat ttcctggtcg ctcatttccc catttttata 930121 ttgatcaaaa cgctttttaa attcttcatt catcattaac acctctatta taaagtgctt 930181 tcagccgctg tctggcacga aataaaacac ttttaaaatt cgcctctgaa atattcataa 930241 tatgggatgc ttctttgtag tttaactctt ttaaataata tagcgttaag gcctcccgat 930301 aattatcggg gagctcggac atataaccag tcagcacttc ctttatctct acctgatggg 930361 caggactttg aacagcattt tgaaagaggc ttccgattaa gtcatcagaa atggttactt 930421 ctttcttatg ctttctgacg taatcaatga aggcgtttcg cgccacttga aaaagccagg 930481 gctttacttt gctgtgatca taggagtgaa tgtgtatgta tgcccgcata aaggtttcct 930541 gcagtaagtc ttcagcaaga tgcttgtctt ttgtcatgga gagcaggaac ctgtaaacat 930601 cattcatgta catttggtaa atttcatcga tcgtcactgc cttttctccc ctctatgtta 930661 tacacgcata agaaaggttt aaagttgcac attacatgca aacggctttt ttatacctaa 930721 tcaaacacca ttactatata gtacccaaaa atggccgcaa aagatagtgc ggagaaaggt 930781 ttaacatttt ttccagaggg gaaaagatag tgaaaaagtg aaggagtggc acaatggaat 930841 ataccagtat agcagataca ggaatagaag cctccagaat cggcctcggc acatgggcca 930901 ttggcggaac gatgtgggga ggcactgacg aaaaaacatc gattgaaaca atccgcgccg 930961 ctcttgatca ggggattaca ctgattgaca ccgcaccggc ttacggcttc gggcagtccg 931021 aggaaattgt cggaaaggca atcaaagagt acggcaaaag agaccaggtg attctcgcaa 931081 cgaaaacggc tctggactgg aagaacaacc agctgttccg ccatgcgaac agagcgagaa 931141 ttgtagagga agttgagaat tctttgaagc ggcttcaaac agactatatt gatctttatc 931201 aggtgcattg gcccgatccg cttgtgccaa ttgaagaaac ggctgaagtc atgaaggaat 931261 tatatgatgc gggaaaaatc cgggcgattg gcgtcagcaa tttttcaatt gagcaaatgg 931321 atacatttcg cgccgtcgca cctctccata cgattcagcc tccatataat ctgtttgaaa 931381 gagagatgga agagagtgtc cttccttatg cgaaagataa caagataaca acattattat 931441 acggcagttt atgcagaggg ctgttaacag gcaaaatgac tgaagaatat acatttgagg 931501 gcgatgatct gcgtaatcac gatccaaaat tccagaagcc ccgctttaaa gagtatcttt 931561 ctgctgtgaa tcaattggat aagctggcga agacacgtta tggaaaatca gtgattcact 931621 tggctgtcag atggatctta gatcagccgg gagcggatat cgctctttgg ggagcaagaa 931681 agcctgggca gcttgaggcc ctatctgaga ttacaggctg gacgctgaac agtgaagatc 931741 agaaagatat caatactata ttggaaaata cgatatcaga ccctgtcgga ccggagttta 931801 tggccccgcc gaccagagag gaaatataac aaaagctgag ggcgaatcct cagctttttg 931861 gcgtttaaac gagagaaatc ttaaaaatta gtaccaggta ataaaaaata ttgttataat 931921 agatgacaga aagaatcatt gattacgaca aaggaagtgc gatatgtata agttttgtgc 931981 aaatgcttta aaagttattc tttctcttcg cggaggagtg aaggtgtata acaaagaaaa 932041 ccttccggcc gattcaggtt ttgtcatcgc gtgtacacat tccggctggg ttgatgtgat 932101 tacactcgga gtcgggattc ttccttatca aatacactac atggcgaaaa aagagctttt 932161 tcaaaataaa tggatcggtt cgtttctgaa gaaaattcat gcctttccgg tagatcggga 932221 aaatcccggg ccaagcagta ttaaaacgcc gattaagctg ctgaaagaag gagagatcgt 932281 cggtatcttc ccaagcggaa caagaacctc tgaggatgtg cctttgaaaa gaggtgcggt 932341 gacgattgcg caaatgggga aagcgccgct tgtccccgct gcatatcagg gcccttcaag 932401 cggaaaagaa ttattcaaaa aaggaaaaat gaagctgatt atcggtgagc ctcttcacca 932461 ggctgatttt gcccacctgc cttcaaagga aagacttgca gcaatgacag aggctttgaa 932521 tcagcggatt aaagaactag agaataaact tgatcagcta taaggcgttc tgagagattg 932581 tcctgaaact gtgaaaataa gaaaagcacc ctatacaagg tgcttttctt attatgcttc 932641 ctgctggtta gctgtctcca gaagttcttc ttcttgaagc tttttcactt caatatatgc 932701 gacgtggtgg ccgtcaattt cattaatgat gaattcgcag ccctcttcga tgatggaatc 932761 atctttttca acatcgtatt tttgagtaag gaaccagccg ccgattgtat cgacttcttc 932821 gttctctaaa tggatgccta gcaggtcgtt tacttggtca attaacactt ttccgtcaag 932881 aatataatgg ccttcgccga ttttgcggat ttcgctaatt tcatcaatat caaattcgtc 932941 gcggatttca ccgacaattt cctcaatgat gtcctcaacc gtcacaagcc cggcagtacc 933001 gccgtattca tcagacaaaa tggccatgtg gaccctctct ttttgcattt tgacaagcag 933061 gtcttggatc ggcgcagatt caatgacatg aatgataggg ttgacgaatt gagaaatggt 933121 ggaatcaaca gatacctcac cgctgatgca ggcggtcagc acttctttaa tgttaataac 933181 cccgataatg ttatctttat cgccctcttc cacagggtag cgggtatatt tttcaatctg 933241 aatgatgtcc atcatttcag aaatcttgat atcatgcgga aggctgacaa tttcggtccg 933301 cggaatcata atttctttcg cgagcctgtc gtcaaattca aagattttat tcacatattt 933361 aaactctgat tggttgattt caccgctttt atagctttca gacaaaatga ttcgcagctc 933421 ttcttctgag tgagccagtt cgttttctga aacggtctcc aggccaaatg ctttggtcaa 933481 taaccgtgcg gaattgttca aaagccaaat gaatgggaac gcgatgcggt aaaaccaaat 933541 cagcggtttc gcaaacagca tagacactgc ttccgccttt tggatagcga ctgttttagg 933601 tgcaagttct ccgacaacaa cgtgtaagaa cgtgataatg gcatacgcaa aaataaacga 933661 tatgacatgt gaaagggaac ctggaacgtt catttggacg aaaagcgggt gaagcagcct 933721 ttcgatcgtt gattcaccta aaacccctaa tccgatggaa gtcaatgtaa ttccgagctg 933781 acacgcagat aaatattcat caagatgcgt ggtcactttt tttacggcta ttgctgcttt 933841 atttccttcc gcgatcagct gatcgatccg tgagcctctg attctgataa tggcaaactc 933901 agatgccacg aaaaatgccg tcagggcgat taaaacagca actaaaatca aattcactat 933961 gtccaattag aaccttcact ctagcaatga gaatgaaggt aacacctcct gttagataaa 934021 atggttttaa cttaacagca gcataaatga ttggaacacg gcgagctttt caggcgggag 934081 tttgcttttc agcttgtcac gatcctcggg cttcagccgt tcaaaccgat gcaagattcc 934141 ggagatgttt tgattcatat gatcaatttc taatgccaga tttccaattt catcatcaag 934201 tttagctgaa gagggaaact ggttctccag tcgatcttta atatcggaca gggccaatcg 934261 ctgcttcttg caatctacaa taaatataag tcgtttgagt gcattttcgt cgtagtaacg 934321 gtaatttgaa caggatctgg ccggcgtaag cagaccgaga ttcgtataat aatcaactgt 934381 ccgtttcgtt actccggcga gtgccgctag ttcactgatg cgataagtct cagccccatc 934441 tatatccctc ccaaccatca cgttatagtt atgagaatag tttaatatat gaacggtgtc 934501 ttgcacaagt ttattgtttt ttttagaccg gaattggaag ttgtggaatt catcatctga 934561 ttgaagtaac ataggaagat agaattttca aatttttata tgcggaaggg acagatgaaa 934621 ttggctgggt tatcccggga agttgaagaa aacttaaata aaggatcatg gattcgcaag 934681 ctgtttgatg aaggtgcaag gctgaagaag gagttcgggg aagaccaggt atttgatttt 934741 tcactcggca acccgattgt tgaaccgcct gaagctttta agagagcgtt aatagaggaa 934801 gctgaaaaag gcagccacgg atacatacaa aaccaagggc ttcttgcagc gagagaaaaa 934861 gtcgcgcaat ttctgggctc gcgttttgaa gctgatttct cagcggagcg catcgtcatg 934921 acggtgggcg cgggaggcgc tttgaatgtt gcgttaaaaa gcatcgtaaa ccctggggaa 934981 gaggtcatta ttcttgcacc ttattttgcc gaatataagt tgtatattga gaactacggg 935041 ggaaaagccg tcagctgccc gttgacaagc cggtttgaga tcgacattga agcggtaagg 935101 caatcgatca ctccacagac gaaagggctg attctcaata caccgcataa ccccacaggc 935161 actgttctca gccagaaaaa tatagacgat ttaggcgctt tattaaaaga aatagaagag 935221 aagagcggcc agacgattta tgtgctgttt gatgaaccgt acagtcaatt aatctatgat 935281 gaagagctgg caaatccgtt tcaatcgtac catcgtgtga tattggccag ctcattcagt 935341 aaagatctcg gcatagccgg agagcggctc gggtatatcg gattggacag ccgaatgccg 935401 gatgcggacc ttttgatcaa cgcttttgtg tattgtaatc gaacgcttgg atttgtgaat 935461 gcccctgtca tgatgcagcg ggctgtggca cgaatggatg atttaagagt agacgcgagc 935521 gcttataaag agcgccggga tttaatggta gacattttaa aagaagccgg ttttgaattt 935581 gaaatgccaa agggaggttt ctttgttttt ccgaaatcgc cgattgaaga tgaagttgca 935641 ttttgcgtgc atgccgccca aaaatacaaa ttattaattg tgccgagcag cggttttgga 935701 atgagcgggc atttccgatt atccttcagt gtgccgatcg agcagattaa aaactcacgg 935761 gacattttca tttctttata taaagatttt gcttaagaag gcaaagaaaa gaaaacagtt 935821 ttcaaggctg ttttcttttt atatccgcaa aatccttcct cttccaatcc agacaggcgc 935881 agaattgaca agcaggcatg cagttaaggc tttcttcatg ataaaagtct aaaaattaaa 935941 aatcattttt ggaatgagtt gtgttacaat aaaatataca atttataatc aaactttgac 936001 ttttggaggt ggtatgatgg ggccctctgc ttaggcaaca atacaccgcg tacctcaatg 936061 ttaaggaaaa atgattatat caggaggtga ctccttatcc tttgttgaga ggatagggtt 936121 aaatggacga tattgacagt ctgattttaa ttggcgtgct cattgcttta accgcgtttt 936181 tcgttgcaag cgagtttgcg attgttagag tgaggagatc cagaatagat cagcttatca 936241 cagaaggaaa caaacgggcg atactcgcaa ggcgtgtcat tacagatttg gatgaatatt 936301 tatccgcatc ccagctaggc attacattga catcaatcgg gcttggcgta ctgggtgagc 936361 cggcctttga acggctgctg catccactgt ttgaaccgct cggcttgccg gactcggttt 936421 cacatgcagt ctcttttgca gtcgcgtacg gcttgatcac gttcctgcac gttgttgtag 936481 gtgaactggc cccgaaaacg gtcgcgattc aaaaggcaga acagctgact ttactgatag 936541 cgggcccttt gcgtttattc tatttgctcc tgtttccgtt tatttggatc ctcaatggat 936601 cggcgcggct tttatgcggg atgttcggtt tgaagcctgc gtcagaacat gatggttccc 936661 attctgagga agaactcagg atgctgttat ctgagagttt aaaaaacgga gagattaatc 936721 cgtctgaata taaatatgtg aataagattt ttgaatttga taatcggatc gccaaagaaa 936781 ttatgatacc gcggaaggaa atggctgctg tgtcaactga gatgacgatg gccgagatgc 936841 ttgaagtcat gctgaaggaa aaatacacgc gctggccagt cacagatgga gacaaagaca 936901 gtgtgctcgg tttggtcaat acgaagcatt tgttttctga tttgctgttt atgacagaag 936961 aagaacgaat gaagatgacg atccatccgt atgtgaggcc ggtcatcgaa gtgattgaaa 937021 cgatcccggt tcatgacttg ctgattaaaa tgcagcgcga gcgcattcat atggctatat 937081 tgtcggatga atacggagga acctcgggac ttgtgacgac agaggatatt cttgaggaaa 937141 ttgtcggaga gatccgagat gaatttgatg aagatgaaca gccgctgatc caaaagcttg 937201 gcgacggcca ttatgtgatg gatggaaagg ttcggatcga tcaggtgaac agccttcttg 937261 gcgcatcgat tcaagaagac gtcgatacga tcggcgggct gatattaaaa gaaaacatcg 937321 atattgaggc tggtgaatcc attcgcatcg gttcatatac gataaaggtg ctgaagatgg 937381 acggccgatt aatcaagcaa atcgatataa aagaagaagc cggcaacaca accgggatta 937441 cggcgcacca caagctgccg ctgcccgagc ctgtgatgct gaacagtgca accttgagcg 937501 agaaataagc tcaaggtttt tttatattgt gattgtccag ccgcaccaaa atgcaaaaag 937561 cgacccgcaa agtgtcagga cgatgtacaa gatgctttct tttacacgtt tggccataag 937621 gagttgaata gtttcaacgc tgaatgtgga aaaggtcgta aaggcgccaa aaaaccccgt 937681 gccaatgata agcgagaccg aagcatttgc aacgtgaagt cctgtaaata ttccgagccc 937741 gagagctccg agaatattga ctgtcagtat gccaatgggc aggctgagac ctttggtttt 937801 ggcggttatg acattgccaa gccagaagcg aagcattgcg ccaagtccgc cccctatgaa 937861 aatacccgct agtgtcattt ttcctgcagc ccctttcttt gctgaatgcc tgctatgcgc 937921 cgtcccacaa aaacaccaat cagtgcaaat atgatccctg atatcaatga ggctgccaca 937981 tataaaagag ccaatgaggg ttgtccttgc aaaagcatca ctgtttcctt agaaaacgtg 938041 gacattgttg tgaagcctcc gcaaaagccg gtgcctaaaa aagccgacag cagaggccgt 938101 tttgccccga tcataaaaaa tccggtcaaa atgcctaata gaaggctgcc tgccgcattt 938161 tccagccagg ttgccgccgg gaactgaccg gtgtgtatcc ataagtttaa tccgtatcgg 938221 aggcaggcgc caagcgcgcc tccgataaaa accgcgctat atattttcat gtttgccatc 938281 ctttatgatg aaatccgggt aatctgtaac gatgccgtcc acgcccatgg cttgtaattt 938341 tgccgctgtc ttttgattgt tgacagtcca tgcaaatatg tttaagccat ttttattgat 938401 ggagccgatc atcagacggt taagccgtgt gtgttttata ttgacatagt ttgcaaaaga 938461 gcggaaggcc ttcatctgat ttctggacag catgccaaag ttgggccttg taatgaccgc 938521 tgtcggaatc gaaggataaa gctcgcggaa cctttggacg gagcggaact gaaaggattg 938581 aacaatatta ttgatagaaa aagaaaattg ccctaatagc tgtcccacct cttcttcaat 938641 tccgacttga gacggatggc cttttagttc aattaaaagg ccgatttttt tgtggtagcg 938701 cttgagcacc gcttccaggg ttggaatacg ctctccttga aaagcgggac cgtaccagct 938761 tcctgcatcg agtttttgca attcctccaa ggtaaaatcc ttaacaaagc ccgatccgtt 938821 tgttgttcgg tcaaccctgt catcgtgtat cacaacaatc tgcctgtctt ttgtaagctg 938881 gacatccagt tcgatcatat ctgcattcat tttcaccgca aggtcaaatg cggcaatcgt 938941 attttccgga gcgtagccgg atgctccgcg atgggcaatg atgtacaagc taagtcagct 939001 cctcgtatgg gcatttctgt tattgtatca aatccatata tgcaccgcga tacaaactgg 939061 tgaatttttt ctgccatatc ggaatggtcc gggctgagga atgcgtataa ctaaaaaaag 939121 acactcagcg tatcagaaca catttcgtca gaaaattagg tctttcgaca tgttcacaac 939181 aaaatatgat cctttataat agcaaaaaag gaggcgagat catgggaaaa gggagaatca 939241 gagtggagga aagaattaaa gccgaaacgg atgctgaaat gcaaaaagca actctccttg 939301 atcagacaca aacgaaaaaa ggtaagtgac tgtccctatt gaatctggct gatagatgaa 939361 ttgagaaatg accccggcgt ttcgccgggg ttttgtgctg cataagacat ttaaatgaac 939421 atccttacga atattttagt ataataaaca attgattggg atagagggga gacagtcatg 939481 ccggattatc tgcagcagta ttttacgctt gataacatca tacaaatcgg catcagcttg 939541 gcgattttgc tggtgtttct tatacttaga aaattattca caagatattt ttttaacctg 939601 ctttttaatt tgacaaaccg gccgaaaaca gaaattttta aacaggtggt tctggcgttt 939661 gataagccgg ccagatggtt ttttgttgcc cttgggctgt ttttagcgat ccggtattca 939721 ccgtttttag atgagcaaat gccggtcatc agcaaaatat accgctcact gattgtggcg 939781 ctcttgtgtt ggggtctttg taatttgacc gcaacatcgt cgtttatctt ccataaggtg 939841 aaccagcgct tcgagcttga catggatgac attctggccc cgtttttatc caaattgctc 939901 cgttttgtga tcattgcgct cagtgtcagt gtgatcgctc aggaattcaa ttatgatgtc 939961 aacggatttg tagcgggcct tggtcttggc ggactggctt ttgcgcttgc cgcgaaggat 940021 accatcagca acttcttcgg cggtattatc attattactg aaaagccgtt tacaattggt 940081 gactgggtgg agacgtcgac agtaacagga tcagtcgagg atattacctt taggagcacg 940141 agattcagaa cagcacaggg ggcgcttgta acggtgccga actctacgct gtcgatggaa 940201 gcgatcacga actggacaag aatgaccaaa cgccagatta cgttttccat ccatgtgtcc 940261 tacgctacgc cgattgagaa ccttgaacgc tccattcatt ctctcagaac aatgctctta 940321 gagcatgagg gcgttgataa tgaaataatc atggtcaact ttgatacgtt tgccgacagc 940381 tactacaatt tattttttaa cttctataca aaaacgacgg tttgggctga aaaccttaat 940441 attagagagg atatcaacta taaaattatt gagattttag gtgcagaagg cgttcagttt 940501 gcatatcccg gccaaatggt tgttgtcaag caaaagcacg aaagcgacca attccaggtg 940561 aatctaaata aagaggaaaa ggaacgggct taaaagagag acttcgtctg acagaggcgg 940621 agtctttttc atggtaaaat aagagaaaaa ggcggtgttg agttggaaac attcaaaagt 940681 attctacatg aagcacagag aattgttgtg ctgaccggag cgggaatgag cacagaatca 940741 gggatccccg actttcgttc agcagggggc atttggacgg aggatgcctc aagaatggaa 940801 gcgatgagcc ttgattattt tttaagttat ccgcgtctgt tttggcccaa attcaaagaa 940861 ttgttccaga tgaaaatgag cggcagcttt gaaccgaatg aaggccattt gcttttagct 940921 gagctggaga agcaagggaa gcaggtcgat attttcacgc aaaacattga cggtcttcat 940981 aaaaaagcgg ggagcaggca tgtgtacgaa ctgcatggtt ctatccagac agcagcttgt 941041 ccggcatgcg gcgcccgata tgatcttccc catttgctgg agcgggaggt gccggagtgc 941101 acggcggccg gaaacaatgg ggacatttgc ggaacggtat taaaaaccga tgttgttctc 941161 tttggcgatg ccgtcatgca ctttgacacc ctttatgaaa agctggatca agcagatctt 941221 ttattggtta tcggcacgtc tctcgaagtg gctccggcta gatttgtgcc tgaggatgca 941281 agcctgattc ccggcatgaa gaaagtcatc ataaaccttg aaccaacgta ttgcgacagc 941341 ttgtttgaca tggtcatcca tcaaaaaatc ggcgagtttg cccgaagttt gggcatgaaa 941401 aagtgagccg ctttatgcgc ctcacttttt tattcatgaa caggaaccat tgtgtcctct 941461 aacactccga aggaatagcc tttttctttt aatttattga ttagtaccgg cagcgcattt 941521 acagtagcag gaagatcatg catgagaatt acatttgggc ggcttgaaga gctgtgttcc 941581 atattctcaa gctgctgtaa tacggcggtc acatactgtg aattccggta tttccagtcc 941641 atgctgtcga tcgtccaatc ccagtacaca aacccatctt tctccagatt gcgaatttgt 941701 gaggcggtta gtgacggctt gcttccgtat ggcgttctga caagatcggt tttatatcct 941761 gtaatgtcct gcagcgtgtc acgcgcctcc tgcatttctt ttagcggaga tgtcggtgtt 941821 tgatagaaca atctgttatt gtgggtaacg ccatgtaaac cgagtgcgtg gccttccttt 941881 tctgctcttt tcacagcctg cttgaattcg ttcatccgcg gtgacagcat aaaaaacgtc 941941 gcttttacat cagcgctttt cagtacgtcg agcaagcggg ttgtaacggc tgaagggccg 942001 tcgtcgaagg ttaagtaaac cgttttatct cccatgttct gctttgtctg cagatgtttt 942061 atcaggagat cgggggagtc gtttttcagc ttaaggcttt ccttctcatc tcgaagctgg 942121 ccgtttgttg tgacagtgac ttcctttgct ttcgttgaac tgttggaata acccaaaatc 942181 accataagca aaagcagcac acataaaact gctaaacttg caaatttaaa agcaagcgaa 942241 actgcagaag gagaagcctc tcctctcgtt tgtcgcataa caatctctcc attggcataa 942301 aatctctaca taatgctgta cagcaggcag cttatgaaga tgccttatgt ttacaaccta 942361 tgtattacca gtcaagtata caggaataaa actggaaagc acatagaaaa tttgtcgaaa 942421 tgtcagattt taaggaaaaa ataaactcct ttccgctata gatctcttga tctttctgtt 942481 tttcagcttg tccaatatgg tagaattagt gataatgaca gcttgaatga catcagggac 942541 atctcgaaaa gggagggctt ttatgaaggt tttagtcaat ggccggctga ttgggcgcag 942601 tgaagcatca atcgatttgg aagatcgcgg ttatcagttt ggtgacggca tctatgaagt 942661 gatcagggtg tacaaaggag tattgttcgg cttacgtgag catgcagagc gttttttcag 942721 aagtgctgct gaaatcggaa tttcactgcc attcagtata gaagatctcg agtgggacct 942781 gcaaaagctt gtacaggaaa atgcggtcag tgagggagcg gtatacattc agacaacaag 942841 aggtgtggcc ccgcgaaaac accagtatga agccggcctc gagccgcaga ctactgccta 942901 tacgtttacg gtgaaaaaac cggagcaaga gcaggcatac ggagtggcgg ccattacaga 942961 tgaggatctt cgctggttaa gatgtgatat caaaagtctg aatttactgt ataatgtcat 943021 gacgaagcaa agggcctatg aagccggagc atttgaagcc attttactta gggacggcgt 943081 tgttacggag ggtacatcct ctaacgttta tgccgttatc aacggcacag tgcgaacaca 943141 tccggctaat cggctcattc tcaatggaat tacacggatg aatattttag gactgattga 943201 gaagaatggg atcaaactgg atgagactcc tgtcagtgaa gaagagttga aacaggcgga 943261 agagatcttt atttcgtcaa cgacggcaga aattattccg gtcgtgacgc tcgatggaca 943321 atcgatcgga agcgggaaac ccggaccggt gaccaaacag cttcaggctg cttttcaaga 943381 aagcattcaa caggctgcta gcatttcata aatgaacgaa gaaaagagcc cgctttttac 943441 agcggggctc tttttatttt ttaacaaatc caatcaaaat ggagatcatt ggcgatatat 943501 agaggaagaa cgtaaatggg atgtagtcta tgactggaac accaagtgcg ctcgccataa 943561 atgcgccgct gacgccccaa ggaatcaatg ggttaattaa tgttccgccg tcctctaatg 943621 atcttgtcag aaattttcgc tggatgtttc gtttgtcata taaagattta aatgattgtc 943681 ccggtattaa tatcgataaa tactgttcgc ccgttgccaa gttgacgccg atgcttgagc 943741 agacagttgc tgcaacaaga cggccttttg agcggatgcc tttcatgacg ccttccaata 943801 gtgcagaaat caatccgatt ttctccatca atccgccgag tgcaaaagca atcataatga 943861 gagagacaga gcccatcatg gattgcagtc cgcctctgtt aataatttta gcggctgcct 943921 cattgtcagt ttcgaaagtt gtgccatttt gtaaagctgt cataaacgcc tgcaggctgc 943981 tgtagggtac aaaaatagca gtcaaaattc ccgaggaaat aattccggca gtcagaacgg 944041 ggattactga tacccgtttc attgccagca aaacgactaa gagcggagaa agaagggccc 944101 acggtgtcac gtttgcagca tcttttattc cggttatgac ctgctgaata ttatcggttg 944161 aagcagcgtc cgctgacact gatgaaccga gaaagtaaaa cagaacgaca gtgatgagca 944221 aagctggaat ggttgtgccc atcatatggc gaatgtgttc aaagattggt atttcgccta 944281 ttccggctgc aaagttggtt gtgtccgaca tcggcgacat tttatcccca aaacaagcgc 944341 cgcatatgac tgcgcctgct gtccattcaa gcggaacgcc agccgcgctc gccacgccga 944401 tcagcgctac tccgattgtg cttacagttg tcagacttga gccaacaagt gtgctgatga 944461 tcatacatga aaacaaagca gtcaacagaa ggtggcttgg ttcaataaag gatagggcat 944521 aaactgtcat agtcggtatt gcgccgctgt acatccaggc gccgattaag atgccgatca 944581 gcgctagaac aataatcggc tgtacgccgt ttttgatccc gtctacaatc cctttttcaa 944641 tgctcttcca gggaaatcca aaccataaag ctgctgctga aagcatgaca acacttaaaa 944701 acagcgggat atgaggttct acatgaagca agaataagca agaaataata atgcacaaca 944761 tgaatataaa taaaccgacg gctaacggaa acgtcagctt tttttgagaa tccaaaataa 944821 caccccatat ttatctttaa tgcttttgtg cttttgggca cgaaagcatt ataacagaaa 944881 aaaacgaaaa tctatgtttt ttcacaatta tgaatataaa agaagtgagc acagggcgtg 944941 ctcactttac aatcaggacg ggtatatccg atttcgctga aagcttttca cttacacttc 945001 cgaatattag ctttttcagc ctgttttggt ctctgcttcc ggttacgatc atatcggcag 945061 aaatgcggtt tgcatgctcg ataattgatt cagccggatc gccttctaat atatcgatat 945121 ctccatctgc ctgctgttca ttcagcatca ttctggcttc ggcgatgact tcttccgtac 945181 ggtcttcata gatcattggc tcaggtgatg ttacatccga tatcagcgga tcaggaacac 945241 ttgtcatgcc tccgctgata tagcttgcct cagctgcggg tctgggcggg tcgatgacgg 945301 tctgattgtc tttcatatca tgtgaatggg cgacggtaat agcggcattt acggttttag 945361 caagatcaat ggctgtcaga agcgctttct tactattttc acttccgtca aacgcaacaa 945421 tgatacggtc agcatggaac atccttctca ccctttcaaa gcgtcttaca acactactac 945481 ccgaatttga gcacaattaa ccttttccta ttcaagtaat gattgacaat aaaaggtttt 945541 gtttatatga tgataaaaag atgaaatcag aatggaagga gggtttgcta tgccaaggaa 945601 tttgcgtgtt tatcaaacag tttcatattg gcgcggcaaa ccttttgttc tgttttcgtg 945661 aacggttttt taggtcggac cgcgcgctga aaagcgctgt gcgtaacata tcggttaaaa 945721 aaggcatgga gctgacgctt catgcctttt ttatatacaa aatctaagga aagacaggtg 945781 tatgggatgt gaagacaaat acagaggcga gggcagttcg tgccaaactg gatgaaaaaa 945841 gctgcaagga aaaaatagaa ggcggctgat gaggagatgg ggatagatgt tttcagtttt 945901 gaaaaagctt ggctggtttt ttaaggcgta ctggctgcgc tatacgattg cgattgtcct 945961 tttattagca gtcaatgtca ttgaaatgtt tccgcctaag ctcttgggga acgccataga 946021 tgatatgaaa gcaggggcat ttactgcgga agggctgctg ttttatatcg gtatcttttt 946081 tgtgctgacg gcggccgtgt atatcatgtc ttatttttgg atgcatcagc tgtttggcgg 946141 agcgaatctg atggagaaaa ttcttcgtac gaagctgatg gggcatttgc tgactatgtc 946201 gccgccgttt tatgaaaaaa accgaacagg cgatttaatg gcacgaggga caaatgatct 946261 tcaggccgtc agtttaacca cagggtttgg catcttgacg ttagttgatt ctacgatgtt 946321 tatgatgacg atctttttga caatggggtt tttgatcagc tggaagctga cctttgccgc 946381 cattatcccg cttccagtca tggcgattgc aatcagtcta tatggaagta aaattcatga 946441 gcggtttact gaggcccaaa acgcgttcgg ggcgctgaat gacagagtgc tggaatctgt 946501 ttcaggcgtg cgggtgattc gcgcgtatgt tcaggaaaca aacgatgttc gccggtttaa 946561 tgaaatgacc gctgatgttt atcagaaaaa tatgaaagtg gcttttattg attcactgtt 946621 tgagccgacg gtaaaactgc ttgtcggcgc aagctatctg attgggctcg gctacggagc 946681 gtttcttgta ttccggaacg agctgacgct tggagagtta gtgtccttta acgtttatct 946741 cggcatgatg atttggccga tgtttgcaat cggtgaactc attaatgtga tgcagcgcgg 946801 caatgcgtca ttagatcggg taaatgaaac tctttcttat gaaacggatg tgacagatcc 946861 aaaacagccc gctgatctta aagagcctgg agatatcgtt ttcagtcatg tcagctttac 946921 atatccaagc tcaacaagtg acaatcttca ggatatttca tttacggtgc gaaaagggca 946981 gactgtcggg attgcaggta aaaccgggag cggaaaaacg acaattatta agcagctttt 947041 gcgccagtat cctccaggtg aagggagcat tacattttca ggtgtaccga ttcagcaaat 947101 ccctcttgac cgtctccgcg gatggatcgg atatgtgcct caggatcatt tactgttttc 947161 acggactgta aaagaaaata ttttatacgg aaaacaggat gcaactgata aagaggttca 947221 gcaagccatt gccgaagcac attttgaaaa agatttgcac atgcttccgt ccggtctgga 947281 gacaatggtc ggtgaaaaag gcgtggcact gtcaggcggg cagaaacaaa gaatttcgat 947341 cgcgagagca ctcatggcga atccggaaat cttgattctg gatgattcac tttccgctgt 947401 agatgccaaa acagaggctg caattatcaa gaacatcaga gaaaaccgca aaggaaaaac 947461 gacatttatt ttgacacacc gattatccgc ggtagagcac gctgacctga tccttgtgat 947521 ggacggcggc gtcattgctg agagaggcac gcatcaagaa ctgctggcca ataatgggtg 947581 gtaccgggaa caatatgaaa gacagcagct gttcactgcg gaagaagggg gagcaggggc 947641 atgaaaatag gaaaaacgtt atggagatac gcacttcttt atcgaaaatt gctgatcaca 947701 gccgtccttt tgctaactgt tgccgtcggt gcagaactga ctgggccctt tattggcaaa 947761 aaaatgatag acgaccatat cctcggcatt gagaaaacat ggtatgaagc tgcggaaaaa 947821 gataaaaatg ccgttcagtt tcacggcgtc tcatatgtca gagaggaccg attgcaggag 947881 cctgtttcaa aagcaaaaga agcgcatatt tatcaagtgg gaatggcgtt ctattttgtt 947941 gatcaggctg tcagcttcga cgggaataga acggtttctg acgggaagct gacgatcaca 948001 aacggagaca agagccgggc atatgctgcc gaaaagctga ctaagcagga acttttccag 948061 ttctatcagc cggaaataaa gggaatggtg ttactgatct gcctgtatgg gggcttgctt 948121 gtgttttcgg tattctttca atacggacag cattatctgc tgcagatgag cgccaatcgg 948181 attattcaaa agatgaggca ggacgtgttt tcgcacatac agaaaatgcc gattcgctat 948241 tttgacaacc ttccggccgg aaaagtcgtt gcgcggatta ccaatgatac ggaggctatt 948301 agggatttat atgtcacagt gctttcaaca tttgtgacaa gcggaatcta tatgttcggg 948361 atattcacgg ctttgtttct gcttgatgtg aagcttgcgt ttgtatgtct ggcaattgtg 948421 ccgattatct ggctgtggtc ggtcatatac cggagatatg cgtcatatta caaccaaaaa 948481 atccgctcga tcaacagtga cattaacgca aaaatgaatg agtcaattca aggcatgacc 948541 attattcagg ctttccgcca tcaaaaggaa acaatgagag aatttgagga attaaatgaa 948601 tcacattttt atttccaaaa caggatgctg aatttaaact ccttaatgtc ccataatctg 948661 gtcaatgtca tccgcaatct tgcgttcgtc tgtctgatct ggcattttgg cggtgcgagc 948721 ctgaatgcgg cggggattgt ttctatcggt gtgctgtacg cgtttgtcga ttatttgaac 948781 cggttatttc agccgatcac aggcatcgtc aatcagtttt caaagctgga gcttgcaagg 948841 gtctccgccg ggcgtgtttt tgaactgctt gaagaaaaga atacggaaga agcgggtgaa 948901 ccggcgaagg agcgcgcgct ggggcgggtt gaatttcgtg atgtgtcatt tgcgtatcaa 948961 gaaggtgaag aggtattaaa gcatatttcc tttactgcgc aaaaaggcga aaccgtagcg 949021 ctcgtcggcc ataccggatc aggaaaaagc tcgattttga atcttctgtt tcgtttttat 949081 gatgcgcaaa aaggtgatgt cttaattgat ggaaaaagca tttacaacat gtcaagacag 949141 gaactcagat cccatatggg tattgtgctt caggacccgt acttattctc gggcacaatc 949201 ggatctaacg taagtctgga tgacgaaaga atgactgaag aagaaataaa aaatgcactg 949261 cggcaagtcg gtgctgagcc tcttcttaag aagcttccga agggcattaa tgagcccgtg 949321 attgaaaaag gcagcacgct atcctctgga gagcggcagt taatttcttt cgctagagct 949381 ttggcgtttg atcccgcgat cttgatttta gatgaggcaa cggcgcatat tgatacagag 949441 acagaggccg tgatccagaa ggcgcttgat gtcgtcaaac aaggacgcac caccttcgtc 949501 atcgctcacc ggctttcaac aatcagaaat gctgatcaga ttttggttct tgataaagga 949561 gaaattgttg agagagggaa ccacgaggaa ctgatggcat tagaaggcca atattatcaa 949621 atgtatgaac tgcaaaaggg acagaaacat tccattgcat aacgctcaaa aacccaaaac 949681 aatcgtgttt tgggtttttg gtttatgtag tcaataagcc agtccgacac ggtttccgac 949741 atactcacct gtaacgagct cacgatataa aaagtccgca gtatcgccga ccgaaatgct 949801 tgtgccgccc tcaggcaaaa cgttacgctc cgtacgataa acgccggttg ctgttccgtc 949861 cgggaggtaa gtggggcaga tgattgtcca gtctaatgat gattctttaa gcatttcgta 949921 tacttttgca tgctccttgg ctgcgcgggt ctgctttcgt ttcgattcat ttgtttcaaa 949981 ccggtatttt cccggttcat atcgggaatc taggatccct gcggtgccga tcgtaataag 950041 ccgtttgata tgctgttcct ccataacgga gagaatgtgt gccatagcag ttgacaaggt 950101 atcatcacca tctgtgccta gacagctgat cacgatttca gcattctcca ttattttttt 950161 cacatcttct aagcggcggg cgttccccat gacagttctg tcttttgaaa ggggaagatc 950221 agcatgttga gatctgatca gagcgaaaat atcaaatctt tcatctgctg cagcttgtgt 950281 taaaaaggct tgtccgacgc ggccgctggc tcctaataaa gcgattttca ttaaaaaacc 950341 tcctcgcctt tcattataaa aggatgttct cagtttgaac agcgcgggaa agaatacctg 950401 tacaaataaa cagaacgatg ggaaacatat tcatgaatca tggatacact tacgaattga 950461 accagctccc aattcacaat ggtgatgaat gacaccccga ttccctccct ttttttctag 950521 gatatgtgga gcaggaaaaa agggtgacaa aataaagaga gcgcggaaac cgcgccctct 950581 atagccatat attgaattgt tattgaactc tgccgcccat ttgctgctga gcgaaagata 950641 ctaaacgttt tgtgatttct cctccgacag aaccgttagc gcgagaagtt gtgtccgctc 950701 caaggttaac gccgaattca gaagcgattt caagtttcat ttgatcgata gcctgagctg 950761 cgccaggaac tagtaagtca tttgaagagt tttggttagc catgtgtaaa atctcctttt 950821 tatttagtat ggttgggtta actggagttg caccaatctg tgaacccttc tcgggtgtca 950881 ctgccgcctc ggcgtaaccc aatgctttgc cggcttgtta ctacgtatta tgttaaaatg 950941 gccggaaaat catgcggaga attgtgtggt aaatcttgag aaataaaaaa agcttagccg 951001 tttaggctaa gctagtcata aatatgaaaa agcatcagtt catgtatctc gtttgtaaga 951061 gcaggctcgt cagcgcgggc gggaaacaag tctccccatt caatctcacc gctcttatga 951121 tagatgcctt cataatgggt ccctttataa taaaatgaaa ttttccatcc gggcagcttt 951181 tcttttggga acaaaggttt ccagctgaaa tgagaaatca ttacggccac gctccttaca 951241 tttggtatca attgacctaa ataaaaacgg cttatgttca ttgtatcatt gtttcagaac 951301 atcattgaag aggcctaaat atgcagtttg tcccagcttt ggataaagat aagcccgctt 951361 tattaaaaaa gcggacaggt tacgaaggcc acaatgcttc cggagatgtg attgccttct 951421 cagataaata tgacgcgtat tcaaaacttc ttcgttttgt aagagaatca acatgatgca 951481 aatttggatg agaaaaaatg cttcggcccg ggcgcgaatt cgcttcaaac atccatactt 951541 taccgttctg atcaatgcca aaatcgaaac caatctcccc gataaatccc tcgatatgat 951601 catgaaggac atggcttgca gtcagtgccg ctgcagaaag ctttttaatg acctcaactc 951661 tttcagcggg atcatcgtat acttccgcaa gtgtctttac agtgccgccg ttagaaagat 951721 gtgttgtaat gctgttcttt ccggaaattt ttacggcgat tgctgtcact gtccattttc 951781 cttttctgtt tttattggta tggacacgga aatccgctgg tttgccttga aattcgatga 951841 gatcaacacc ttgctgaatg agaaagtcgg acgggttgtg atgtttttga aattctgcaa 951901 ggaatgaggc ggcatcggaa taatcaattg atgtaaaagt tttggcgtca ttcgtatgct 951961 ttaccgtcag gccgccatct gttcttgtca gctgataaat gccggtgccg agtgctccat 952021 ttgccggttt gatatagact tttttgtatg cgccacagag ctcatctatc agctccacag 952081 acggtgtcag ctcggatcta ggcaaaaagg gtgccgttct tggatctttt tcgagcaatt 952141 gatgaacgtt ccatttattg aaaaacgttt tattaaacca tgggatctga tattcatcga 952201 tcagcctctt ttttgtatgt tgcaagagaa gtgaatcttc aatttttcgg ttcggcaaac 952261 ggtcataaac gacgttcggc aatggaacga tttttttctc ccagccgttt tccctgtaaa 952321 ggaggccttc aatcgtgcct tcctcccaat tgatttggtg cgcgccaaaa acgaagcagt 952381 agcccccggc ttgctcgtgt aacgtgacaa gtttagaaaa aaagagggaa cgatccttaa 952441 atgggcgttc aagagataca gtaaaccctg ccgtaaagat gccgactaac ggcccgatat 952501 gcactgtatg atcatgaatc agtatatctg ccctgcttcg gtggggaagc aaaagctcat 952561 gaaacagatt ttcagagaga agcacggttt gttccagatg ccgtctgtaa gcaacgtggc 952621 atctgacaac cttcgttccg aatgcggcat gcaaaagtcc gtcttgcttc agcgaagagg 952681 gcagaaacag ggtgttttca ctggttttgt ctatgccgat caaaaaccgt ttaggattca 952741 cgcggaagaa ctcctttctg gctttgctca gaaaacagat attggcagcg ttttagggga 952801 caagtgtaca gctgttcttt ttgctcggga gagacacgca ggattgactt cctgcctggt 952861 ttggaattga tatctaaaat ccaaattctc ccgtcctttg caagacatat atcaagaccg 952921 agttcaaaca acggcccata gcgctcgtca agataatacg gaaccgattg ggtaattgaa 952981 aacacatcat ctagtaaaac cacttgctgt tttttcggta tatcttcaaa ccaggagtca 953041 aatgtcagcg catcagatcc gcctgacaaa ttggccagca gcccgtgttt gtatccgcgt 953101 cttactgcct ttccgactgt attccattca cctgcttcgt ttttttccat aaacagacga 953161 atatcacaag ggtattgttc cttatcttga atgtttaagt aaggctgaag caaatattga 953221 tgctgaagca cttttttgca ccatgtttta aaagaagtct ggttggaaaa cgtttttgtc 953281 tgcttatcct ttccgatgtg ataagtagca gtgatgtttt tcttgcccag cttcaaaaga 953341 atcacgcctc tgcctcccgc gccgaatgcc ggtttaagga tgcaggcttt ttctttggat 953401 aaaaaggagt gaatttgttc gtagcggctc acctttatcg tttcgggaat atagggattg 953461 attacagagt gctgctgcaa atcgtgaagg acggtccact tatcgggaag accccgcccg 953521 ataaattccg ttttcggata ttttttgagc cactcaacga ttggttttgc tttttgggaa 953581 tgtgaatcct tgccgtaaaa acagcgatca taaatataat ctggaatcgc catttcagtt 953641 tcgttccatg tgctgctggc cgaatgatag accgatgctt tgacacgcaa agtgtcaggt 953701 gaaatatcaa atggtgtaaa ccggatgaaa cgtatgccga attcgggtgc tcttttggcc 953761 agttctgcgg aataatccgc ttcatgctgg cgggataagg acataaaacc gagtgttatc 953821 atggtgagac tccccctttt attcaaaagc tgccggcggg tgtccgcagc tttacactaa 953881 atacatgtaa gacgaacgca gctgacggta ttctacttta cagaatacga ttctccacct 953941 tgccctattc caaaagaaca agctgatttt ctaagaacag gaatttgtct cctcgtttgc 954001 taagtgattg catgagcctc tataatacgt ataggtacat aatctatatg aaaaaagctg 954061 aagcacagat ggaggaagat gaataggaat gggtattgca ggaaccttta tttttatgat 954121 cgtgatcggc gctgccattg gagcggtgac caatcattta gcaattcaaa tgctgtttag 954181 gccgtataaa gcgtactatt tgtttgggaa acgagttcct tttacgcccg ggctgattcc 954241 aagacggcga gatgaacttg caaaacaaat gggactgatg gtagtcaatc atctcttaac 954301 ccctgaaggc attaaaaagc ggctcgtctc tgatgcagcc aaaacgcagg ctcttcgagt 954361 gggggaacag ctgattcaaa agctgtcact ttctgaagtg acagtaaaag aagcgcttga 954421 aaaagccggg atgaagcgcc ccgaaaaagc tgctgatgca tggatcagca gctggaccga 954481 tgataagctg catgagcttt tccgccaata cggggaccaa tcgttaaaag agctggtgcc 954541 tatagaggtg caggaaaagc ttgaggaaaa aattccgatg atttcaggat atatattgtc 954601 acggagtgtc cgttattttg aaagtgatga aggaaaaatc cgtcttggca atatgattga 954661 tgacttttta aaagagcgcg gcatgcttgg aagcatggtg caattgtttc ttggcaattc 954721 aagccttgcg gatcgcgtgc tgccggagct gctgaaattc ttgcgcaatg aggaaacaaa 954781 taaattgctt tctgatctct taaaaaacga atggggcaag ctgagggagt atacgtttaa 954841 tgaagcagat gaaaaatgga atgcaaaggc gctcattttc agtttgaaac gaagagtgct 954901 gcaagcattt tcgactgccc ctttcttcaa caatacgatt ggcacgctta ccgtccgcta 954961 tgaatctgag ctgacccagc aaatgctgcc ggcactatta gacaaattgc ttgaaggtat 955021 ttcgtccaac cttgaaagtg tcttaaaacg gttgcgtctt gaggaaatcg tcaaggagca 955081 ggtggatcag ttcccggtgg agcgtcttga agaaatggtg ctgtccattt caaaaaaaga 955141 atttaaaatg attacctatt tggggggcct tctcggcgga attataggcg cgattcaagc 955201 attgtttgtc atcctttttt aagaagaaat ggtttttgat taatgaaagg agctccatag 955261 tctgttatag tggagtggta tgtcaaacgg caatgatgaa aggagctatt tacaatggct 955321 gttaattttt atgatgtagc gtatgatctg gaaaatgcat tacgcgggag cgaagaattc 955381 acccgtttaa aaaaccttta cgacgaagtt aacgcagatg aatcagcgaa gcgcatgttc 955441 gaaaacttcc gtgatgtaca gcttagactc cagcaaaaac aaatggcagg agaagagatt 955501 acacaagaag aagtgacgca ggctcaaaaa acagttgcgc ttgtacagca gcacgaaaaa 955561 atttctcagc tgatggaagc ggagcagcgc atgagcatgc tgattggtga attgaacaaa 955621 atcattatga agcctttaga agagctttac ggcagtgttg aaggctaata agcaaaatcc 955681 cttcttggat aagaagggat tttttattca ctcagcaaac ttggaaatcc aatgaatctt 955741 ttacctctcc attgatgatg actgataatg tatgaattcc tttgtaatgc tttctggtgg 955801 ttaaatcctt aaaggattgg attcttgtgt atgacttcgt ttcgtttttt cgtatatttg 955861 tttctgttat tttaaatact ttctgatgac gctggcctct tgcttttaca aaatcaattg 955921 cgtactcaat tcttactttt tgatccctgt ctgaatgaat atagaaagaa aattcaaggc 955981 tttcgccaat aactatacgt ttgggctggc atgttaaatc atgtagttgt atcgaatcag 956041 cattttcata accaaaaagc gctaaggcct gtttatcacc cttttttaat aaggtccgat 956101 aggcgtgttt gataatccag tctgtatggg gatgtgttcc gtaccattga tctgcgactt 956161 ttctcagtaa atgaggatgc gtttttgata tatcattaag gttgttggcc acgctttttc 956221 ttacatataa agactcgtcc tgcatcagct tctcaaggat cggcaatacg ggggaagggt 956281 ccgatttcaa agccggtatc gattttcccc atggcaggcg gggcctgctg ccttcgctcg 956341 caagtcttct cacgtgttca tttttatgct cagaccatgc aagcaattgt gcaatcatct 956401 tttcttgatc taacagcaaa aaaggcctta cagcaaattc tgaggtcgaa tattgcgtaa 956461 aggattccaa tgcctttatt gattcttccc aatgcgctaa cccgtactgt tccacataat 956521 ctggaaataa aattccgctg agtcctttaa aatgaggggc tgtatcccgt aaaattgtga 956581 gcgcttcaac gtattgtttt ggcaaagttt cgtataaaga aactgtcacg cggcgcatcc 956641 gctcttttaa agtgagttca ggccagtcct ccagccgtaa tgtatccaag aatctgtttt 956701 tgttaaaatc aggataggat gaccttacat gatggatcaa ctgagatatc agttcttcat 956761 tatatatttc ttttaaatca gccatataaa caccgctttt tcgtttatta tttatattgt 956821 atgggaatgt acgttctgga tcaagtgtat agtcctaaaa attaacaact gatcctacca 956881 cggatataca aaagttggtt acttttttta gttaaaaaaa cccttgtcat cggaaaggaa 956941 aactgagata ataacattga aagcgcctac acttacctat ttcaaatgga tacggtcgca 957001 tatcatgccg ttatatagag gggataagca acagagagta agtgttcgga gcgcatcatt 957061 ggtcaaacaa ggggttcctg atacatgatt tttcgtaaat cgaaataacg atattaggga 957121 gaatggctgc ttcgatcgta tcctatcaac aagccataca taaagtctgc tgagccaggc 957181 tttttttgct ttaagaaaag gttgttctaa acacagagac agggtcatat cctatacaca 957241 agtacagtca tcaaggaggg ggacatctct gtgtcaaaac aattgcttgc cttaaatata 957301 gatggagcgc tgcttcggtc gaacgggaag attcatcagg caacgaaaga cgcgattgaa 957361 tatgtaaaga aaaaagggat ttacgtcaca cttgtgacca accgtcattt tcgctcagca 957421 cagaaaatag cgaaatcgct aaagcttgat gccaagctga tcacccatag cggggcatat 957481 atcgctgaga aaattgacgc cccgtttttt gaaaaaagaa tttctgatga tcataccttt 957541 aacattgttc aagtgctgga gagctatcaa tgcaatattc ggcttcttca cgaaaagtat 957601 tccatcggaa acaagaaaaa ggtgaattcg aatttattag ggaaagcact cattcatccg 957661 tctgacccga tcttttatcc agtccagttc gttgaatcat taagcgatct cctcatggat 957721 gagccggtga gtgcacccgt catcgaggtg tacacggagc acgacattca gcatgacatt 957781 acagaaacga ttacaaaagc cttccctgcg gtggacgtga ttcgcgtaaa cgatgagaaa 957841 ctgaatatcg tcccgaaggg tgtctcgaag gaagcgggtt tggccctcgt cgcttcagag 957901 ctgggcctga gtatggatga tgtcgtggcc attgggcatc agtatgacga tctgccgatg 957961 atcgaacttg ccggtcttgg ggtagcgatg gggaatgccg ttccggaaat taagagaaag 958021 gcagattggg ttacaaggtc caatgacgag caaggtgtcg cttatatgat gaaggaatat 958081 ttccgaatgc agcagcgaaa aggatttctt gataagttcc acatgaaacg tgtgtaaaaa 958141 agccgctcgc gccctgacag gtgcggcggc ttttttgccg gattgatttt agcagtttat 958201 ttctgtacac taaagaaagt tttgaatctg ataaattagg tgatgaagtt gcaaattaaa 958261 atagaaggca tacatgatga ccgcctgcat cggcctctgc aaaatattgc aaatttgttt 958321 tatgaagagt gcgagcttgc gtatggcgga gaggagcccg cagattttgt catttcttta 958381 gcgttgtcac aaacggatga gcatgtgacg gtttctggag aagtgaaggg tactggcata 958441 aaggaacagc atacaaaatt cttttctcca gacatgactg aaaaagaagc ttttaagcaa 958501 gtgaaaaaca caatttctta tgtgtatctc aatcttcttc aggcgcatac gggcattacg 958561 cagaagtggg gaatcctcac aggaatccgg cccacaaagc tgcttcataa aaaactgcaa 958621 agcggaatgt ccaaggagca agcgcatgct gagttgaaaa aagactattt aattcatgat 958681 gaaaaaatca tgctaatgca ggaaattgtt gaccgtcagc tggcggcagt gccggatttg 958741 taccgagtaa aggatgaagt cagcatttat atcggcattc cgttctgccc gacaaaatgc 958801 gcgtattgca cattccctgc gtacgctatc caaggacagg cgggcagagt cggctcattc 958861 ctatggggac tgcattacga aatgcagaaa atcggtgaat ggctgaagga gcatgatgtt 958921 aaggttacaa ccatttactt tggcggcggg acgccgacaa gcattacagc ggaggagatg 958981 gatctgctgt atgaagaaat ggtccgctcc ttcccggatg tgaaaaacat tcgtgagatt 959041 acggtggagg ccggtcgtcc tgacacgatt acagaagaaa aactcgccgt tttaaacaaa 959101 tatgacattg atcggatcag catcaatccg caatcctacg aaaacgaaac gctaaaggcg 959161 atcgggcggc accatacggt tgaagagacc attgagaaat atcatctgtc acgccagcac 959221 ggcatgaata atattaacat ggacttgatt attggtttgc ctggggaagg cgtgaaggag 959281 ttcaggcaca gtctttcaga aacagaaaaa ctgatgccgg aatcccttac cgttcatact 959341 ctttcattta aacgggcgtc agaaatgacg agaaacaagc ataagtacaa agttgccggc 959401 agggaagagg tttctcaaat gatggaagac gcggtagcct ggacgaaaga gcatgggtac 959461 gtgccttatt atttataccg ccagaaaaac attcttggaa accttgaaaa cgtcggatac 959521 tctttgccgg gacaagaaag catctacaac attatgatta tggaagaggt gcagacgatt 959581 attggcatcg gctgcggcgc tgctagtaaa tttattgatc gggatacagg gaaaattacg 959641 cattttgcga atccgaaaga tccgaaatcg tacaatgagc gcttcgagca ctacacggac 959701 gaaaaaatca aatatttaga gcagattttt gaaaaaacga caaagcagca ctgattacag 959761 tgctgctttt tttatccctg tttttttgcg ggctgaacct caggcttcca tttaaatacc 959821 ttgttcagca agcggtaaat tcgttttgat tcctttgtga caagcggtcc caaaatcgcc 959881 agaatgagga catataatgc ggcaaacggc tttaatgtgg ccgacagtcc gccggctatc 959941 ccgagattcg caacgataat cgaaaattct ccccgcgata cgatcgtcag cccgatattc 960001 gatgaagcct tatgagaaag ccctgcgcgt cgtcctgcca ccattccggc gataaaattt 960061 cccagaatgg tcaaaatcac tgcacccaac gcaagccaaa ccgcttcacc aagcgaaaac 960121 ggatcgatgc tgaggccgaa gctgaaaaag aacatcgcac cgaagaagtc gcgaaacgga 960181 acaacgaggt gttcaatcct atcggaatgc tctgtttctg aaaagaccaa accgagcagc 960241 agcgcgccga ttgcttctgc tacatgaatc gtctctgaaa aaccggcgat aaaaaagagt 960301 gctgcgaaaa tgacgataat aaacacttcg tttgagcgaa tgtccaacag tttgttcaac 960361 agcggcggga gttttcttgc tgcgataaaa aacagcagca tataaccgaa ggcgatcaaa 960421 atggacaaga gtgcactccc tacggatgtc gcatcaccta gtataaggcc ggaaacaacg 960481 gacagatata cggcaaggaa aatatcttca aacatgatga tgccgagaat caattcggtt 960541 tccgggttgg cggttctttt taaatcaacg agcacttttg cgacaatcgc acttgacgag 960601 attgtgatga cgcctgcgag gatgaggact tccagaaagg aaaatccggt gataaacccg 960661 taaagcagtc cgaggctgaa gttaatcaaa atataaatcg tcccgccgac cgcgattgat 960721 tttcctgatt tgattaactt cccgacagag aattcgagtc cgagatagaa gaggaggaac 960781 agtacgccca ttcgcccgaa aaactcgatg atttcactgc tttgaataaa tgttagatca 960841 ataatcccca ttttcggcgc gtgcggtcca acaagcattc ccagcacaat cagaaacgga 960901 ataatcgaaa atttaatttt attggcgatc acactggcga ttgccacaag cacaagtgca 960961 gttccgactt caaatacaag atggtccatc ggggctcaca cgccctctcc agaaagaaaa 961021 tcgtgaatca gtttcttcag atgctttctc tcacctgaga ggacaagggt gtcattttct 961081 tcaataatcg aatccgctcc gggatttagg agcttttcct ggttgtgttt gataatcgca 961141 ataacagtga catcgtaatt ctggcgaaca tcaagctcac cgagtgtgcg tccgatcgat 961201 ttggcgcctt tttcgacctt aaaccattca ataataagat cgctgaaggc catttcgatg 961261 gactccagag cttgcggttt atagaccatg cccccgagaa tagctgcaat ttgccttgct 961321 tcagaatcat ccaatgaaat atttgaaaga agctcatccg ggtcccggtc attaaaccgg 961381 taaatttccc ttcttccgtc atcatgaatg ataatcgtca ttttttcgtg gcttcttgtt 961441 tcgatttcaa actttttgcc gatgcccggc agatcgtttt ctttaatatt caatgaaaat 961501 ccctccgaat gtagtgttgg cagtatgggg tgagttacaa ataaaacttg agcaaattat 961561 attcggaggt aattagactg gtatttgaca gggacggcca aagccttttc cagcctgttt 961621 atcagcggtt cgtcaagtgg tttgacagag agctgcctga cagactgcgc cagcgggctg 961681 tactctttga tcagctcagc cgggtgcatg ctgcccggcg atggcgtttt tgccgattgt 961741 gtttcctgcg gatatgaaga cataggcaca tagctgtcag tgcttgcttc aaactgggaa 961801 ggcagaacca cgtccgaagg gggaaagtac accataaata aacttaacag aaaactgatc 961861 agcaatttat ccatgttcct ttcctccctt ctcatcaaga tatcccttct ttttcactat 961921 ataaaacttt atgtttccat tcaaacaata tgcatttttc agtatctatt gaccttgaaa 961981 aataaaaagg tttatttggg gatggcgggg aatgtatagg agaaagaaaa aagtaagcgc 962041 atacatggag gtgcttttaa tggagtttgt tcaatatgca tgtaatgggg ccgttgcaga 962101 gattatcctg aatcggcctg atgcccatca cgccctgaat gaacagatgc tgtctgaatt 962161 gaaggaggca gtcgaaatgg cggctgcaag cgaggcgctc atcgttctcc tgagaggaag 962221 cgggaaaggc ttttcggccg gcggtgatat caggatgatg acgtcagagc atgaccctga 962281 ccaatttaaa cggctgatgg atacgattga ggctgtcacc ctgaatttat atcagatgaa 962341 gaaagtgaca attgcagcca ttcatggtgc tgctgcggga ctgggcctga gtttggcgct 962401 ttgtgcggac attgtgctcg ctgaaaaaaa cgccgttctc gcgatgaatt ttatcggcat 962461 tgggcttgtt ccggacggcg gaggacatta tttgctgaag aaaagaatcg gtgaagcaaa 962521 agcgaaaaaa ctgatttgga gcggaaaaaa actatctgcc tcggaagctg ccgatatggg 962581 gcttcttgat gggacatttg ccggagaccc tgccgaaggc gcaagaccca ttatcgaaac 962641 cctgttggcc tcccctcttt tggcgatgat cgaaacgaaa ggtatttttc aaagcctcca 962701 aattgaagaa ctgaaaaaag tgctatccct tgagcgcagc gcccaagaga gaatgagaag 962761 gaccaaggat caccaagaag gaatccgtgc ctttttagaa aaacgggagc cgaagtttca 962821 agcgtaacag atcagccgga aagctgatca tctgtgaaac aaaatcagct ttccggctgc 962881 attgactaaa cgatgagtat gactatgaag ctctttttct tttaagaggg cttcaccatg 962941 cgtttttgcc gcttcttcat gttctgcctc gaattgctcg tttaccagcg tgttccccga 963001 aggatcaaat acggtaagga aataatcagc catcaggttt ctcctccatt ttaaggttta 963061 tcagtctttc ttcatttata ttctaaaaag gaaatcaaaa tcctttatta tgctttatcc 963121 aaaattagta tataatgggt cagggaagga ggagattcag tgcttacaat tgatcacgta 963181 acgaagacat ttggagatta taaagccgtt gacggattgg acttagatat tccggaacag 963241 caaatgttcg gtctattagg cgcaaacgga gcgggaaaaa caacaacgtt tcgcatgatc 963301 ctaggattat taagcattac ggagggctca atcagctgga agggccgtcc tgtgaattat 963361 catatcagca acaaaatcgg ttatttgccg gaagagcggg gcctttatcc gaaaatgaag 963421 gtaagggatc agctcgtcta tcttgccaga ttaaaaggga tggagaagcg agaggctgta 963481 aaagagctcg ggacatggct tgaacgcttc aatattacag attacgagaa taagaaggtg 963541 gaagagcttt cgaaggggaa tcagcagaaa atccaattca tttcggcagt tttgcataag 963601 ccggagctcc tgattcttga tgaaccattc agcggcttgg accctgtcaa tgttgagctg 963661 ctaaaagagg ccgtgatctc gctgaaaaac agcggtgttt ctattttatt ttcaagccat 963721 cggatggaac atgtggagga gctttgtgag aacctttgca tattgcagaa aggaaaaccg 963781 gttgtacaag gcaagctgaa ggagatcaag cgttctttcg gtaaaaagaa tgttaccatt 963841 cactccgatg acgatctgcg ctttttgcag tcccatgaag gcattcttca atggaaggaa 963901 acggcagacg gcgtcaagct gcagattgcc aatgaagaca tttctcaaga gatttttgcg 963961 atgctccaag gaaaagggtt tatcagaaag tttgagcttg aagagccgtc actgcatgat 964021 atttttatag aaaaggtggg ggccgtctat gaataaattt tggatcatgc tttctcatac 964081 atacaaaaat aagattatgg caaaatcctt tattatttcg actgtcatca cggtgctgct 964141 tgttttagtt gtaacgaatc tggagtcgat catttctttg tttcaaggtg acgatgcgaa 964201 agaaaaaatc gccgttgttg atgaaacaaa cgaattatat ccggtttttt ctaagcagct 964261 gaaagcggtg gatacagacg gcgatcttga tgtgaagctg tcgaagcaat cggaggatga 964321 ggtcacaaag caagtcaaag atgaatcact cgatggcatg ctcatcatca aacgagatga 964381 aaaagggacc atttcaggaa catataaagc gttaacgatt tctgatgaaa gcacgtatca 964441 aacactgcag caggcgctga cgcaaaccaa aacagctgtc ggaacagcgg agctcggcgt 964501 gtcgcaggaa acgattagca gcctttatgc gcctgttact gtggggcaga aggcgctgaa 964561 agaaggggca aagtctgagg aagagcttgg ccagacggta gggcttgttt acattatgct 964621 gttcgtcatt tatttctcgg tgattatgta tgccagcatg atagcgatgg aggtcgcaac 964681 cgaaaaatct tcgcgagtta tggaaatcct gatctcaagt atgccgccga tccagcaaat 964741 gtttgcaaag ctgcttggta tcgggcttgt cgggatcaca cagcttgcta ttattatagg 964801 agccggctct ctgtcgctta agctgaacca aaagagcgaa acggcttcat ctgtcggcgg 964861 attccttaat ttgaccgacg tatctgcaac cactgtcatc tatgctgtca ttttcttttt 964921 gctcggatac tttttgtacg cgacacttgc cgcgtttctc ggcagtgtcg tcagcagaat 964981 agaggacgtg cagcaaacga tcacgccgat gacgcttttg gttgtcgccg gttttatgat 965041 cgcgatgttc ggtttgaatg cgcctgacgc aggatttatt acggtaactt cgtttattcc 965101 gttctttacg ccaatgatta tgttcctgcg cgtcggcatg cttgatattc cgttctggca 965161 ggcggctgtc ggaatcggaa tcacactgct caccattgtc atactggccg ttatcggcgc 965221 cagaatttat aaaggcggtg tattaattta cggcaattca agcgcgttca aagcgatcaa 965281 acaagcgcta cgtttagcga aaaactgatt ggaaaacagc ctggggattc tcaggctgtt 965341 tctttattga cagaacgtgc attcgcaaga attcggtgct aaaataaggg tacttcatcc 965401 tggaaaggag cagaatgttg actgatctaa cctttattca tgcggcagat cttcatcttg 965461 acagcccgtt ttacgggata tcgcatctgc cggagccgat ttttgcccgg attaaagaaa 965521 gcacgtttgc aagcgtgaga catatgatag acgccgcagt gagagagcac gttgatttca 965581 ttttgcttgc gggagatctg tttgatgaag ccaatcgaag cttaaaggct cagctctttt 965641 tgaaaaaaca gtttgaaaga ctcagagagt gcggaatttc ggtatacgtc atctttggga 965701 atcacgatca tcttggcggg gagtggacgc cgattgaatg gcctgagaat gtccatattt 965761 tttcgtccgc tgttccagaa gaaaaatcgt tttttaaaga aggcaggcgc atagcaagca 965821 tttacggctt cagctatcaa gccagagcat tgatggaaaa ccaagccgcc cgctatcgga 965881 gatcaactga cgcaccgttt catatcggca tgctccacgg cacgctgtca ggatctgaag 965941 gacacgatcc gtattgcccg tttacacatg acgacctcgt gaaaagcggg atggattatt 966001 gggcgcttgg ccatatacat aaacgccagg ttctatctgc cgagcatccg gcagtcattt 966061 acccgggaaa cacgcaagca cgccatataa aggagacggg agataaaggc tattatctcg 966121 ttcatgtgac aaacggagat atatcttatg aatttcagag agcgcatgat gtcctgtggg 966181 aaaaagcggc ggttgatgtg acggaggcaa agaatatgac agccctcttc caaatggtgg 966241 aggacacgtt ttcgaagctg cggaaaaagg ggagccctgt ttgtgtaagg cttgttttac 966301 aagggacggc gccggaatgg ctgctggagg cgccaaaagg caccttggat gagtttcttg 966361 aagctcttca ggaacaagaa gcggaagagg aacgtttcgt ttggcctctt agattggacg 966421 atgagacaga aaacgaagca aacctaacaa accttgatcc tttttttggc ggtttatttg 966481 aagacattga tcgcagcgat ctgtcagacg tgctggaagg gcttgagcgg catccagtgt 966541 atagaaggca cgcggaccgg tttagccaag aggaggtaaa ggaaataaaa gagcaggcac 966601 agataatatt gaaaagacag cttaaggtgc ttgatacatg aggcggtgac agctttgcga 966661 attatatctt tacatatcta ccaatacgga aaattttcca atcggacctt tgacttttcc 966721 gcctctcctg tccaagtcat ctacggatta aatgaggcag gaaaaacgac gatgatgtca 966781 ttcattgaaa gcatgctgtt cggttttccg aaaacgaaaa agtatgaacc gaaaacaggc 966841 ggtgtctacg gcggtgttct tgaagctgaa catcctgagt atggggtgct gaagatcgaa 966901 cggacgaaag ggactgccga aaaactaagc gtgtacacag aaaagggcga agtaaagcag 966961 ggagatgttt taaagcagct gttccagggc acagacaggt cgttgtacaa agccatatat 967021 tcgttcgacg tattcgggct gcaggaaatt cacgccttta atcgggacaa gataggggaa 967081 tttttgctct tttccagctt gtttggtgct gaagccgtat caaagcttga ttcaaggctg 967141 acgaaggaaa gcgaaaggct ctataaacca aatgggcgaa accctcaatt gaatcaggag 967201 ctggaaacgc ttaagcagct ggcagttaag ctaaaacagg ctgaagcaga ggaagcgggc 967261 tatcatcagc ttctcgagga aaaacgaacg cttgaagccc gccttgcagc cgcggaaacc 967321 gaattgaaag agacggcggg acatatccga atgattgagg gagcgattga gcgaaagccg 967381 ctgctaaatg aaaaagcgac actcgaacag gtgattgcag aatttccgga acacgcagga 967441 caatttcctg ctgacggact gcatcagctg gaaaaatatg aatcccatct tcacccgaaa 967501 tcagcacagc ttgaggcgct tcgggtgaag atggcggagt tggacaaaca gaggcaaaag 967561 cttatccccg ataaagaact attggcgaaa gaaacgctga tacaagagct ttcggcagcg 967621 tttcatatgt accaatcctg gggagaacag ctggcagcca ttcaggcaca gctgcgccag 967681 acgtctgcgc agacagcggc agggctggaa cagctcaata aaacggatga aaatgagctc 967741 ctgaatatga acacctcata tgattatgaa tggcagcttc agcaagcggt gcagcaatat 967801 gtacaggcaa gagacagaaa acggcagctt gacgagacgt ttgaacttgc ccggcaagag 967861 ctggaagacg cggaaaaggc cgttcgtgcc gcttcgtccg cgattcttga aaacagccaa 967921 agaaaagata aagaagcagc tcttagagca tatgatgaaa cacaggggca gcaccaagag 967981 caagcgaagc tcagagaaca gctaacgttt tttgaaagac agcaggctaa acagaaaaag 968041 actgtcattg cagctggtat gttgttcatc gttctctttt ctctgctgca gcaatggatt 968101 cccgccataa gtttcggcgc tgcacttatt gtgtattggc ttgtttcagg aaagtcgtct 968161 tctcgaaaca gccgagagac aagacagccc atgacggata tttcaccagc agaagctgaa 968221 atgcttagag aagcgttatg ggaggatgac cgcaataagc agcaccttct cacacagcgt 968281 gcagcgctcc agcaaaaaga ggcggcgtat gaaagggtca tccagcagtt tgaacagtgg 968341 gaagccgaaa tggcgccgtc ctttacacag gttgagcgtt ttatgaatga gctcggattt 968401 aaggaagatc catcattttt gcttgatgca tacagcttaa tgaaggatgt taaaaaagaa 968461 gtgaagaaaa agcatgagct gaccatagaa gcaggcaggc tgaaaaagca ccggagaaca 968521 ttcgaagaac gcgtcagtat gcttcttccc gtgaatcaga gtcaggatat ctccatttcg 968581 gacgcccttc acacattgcg gaaaaacatt gaacgtgaaa aagaaattga gaagcaaaaa 968641 aaggaaattg aaacagatat tcattataca aaggaacaga tgcttgaact tgagcaagaa 968701 atacagtatt tccacgcaca gattgaacag ttatttgccg cggctgctgc aaaagacaga 968761 gatgcgtttt ttgccatagc cgccatcagc aggcaattga aggatacgga gaacaagctt 968821 catcacgtaa acgcacagct tcaaggcggg tacccggagg aacttgaact ggcggattcc 968881 aatacgcttt ctgaattgaa agataagcaa tttgttgaga atgaaagaaa agagcggctg 968941 actgaggaga tcgagcagct ccgcagccaa atcgcactgc tctcagtcaa acaggaacaa 969001 ttagaggctt cgggaatggt ctcagacctc aagcttcaaa ccgaaatgca aaaagaacgt 969061 gtgaaagaaa cggctaaaaa atgggcctcc atacaaatgg tcaaacaggt gatcagaaac 969121 aaattggagc ggcataaaaa aatcgagctt ccgcgccttc tggagacggc aggagaattt 969181 ttccgtcctc tgactgacgg aaactaccaa accatttatt tttccgaaac ggatgattcg 969241 atcatggtta tgcatcgcga tggcactgtc tatcatgcgg aagagctgtc acaagggacg 969301 tgtgaacagc tgtatacagc gatccgcttt gctttggccg ttacgcgcca gggtgagtca 969361 aagcttccgt tccagcttga cgacagtttt gttcattttg atcaggaaag gctgaaacgt 969421 gtattacatg ttctgtatga tttatctgaa ggcggtaggc agattttgta ttttacatgc 969481 catgagcacg taaaagatgc atttcatagc agccaaatca tccatttggt gtcataaaag 969541 aggttctata gctgaaaatc ggtatgtgat atactggtat tatgtaagat acggagggag 969601 ctttaataga atggctaaag ggattatgct acatgaggtt ggcgaacagg tggaccagta 969661 tctattgatt aaatcctcga cgaaagggat tgcaagcaat ggaaaaccgt ttctgacgct 969721 gatgctgcaa gaccagtcag gcgatattga agcgaagctg tgggatgcca agcaaagtga 969781 tgaagtgacc tatgcgccgc agacgattgt caaggtcgtc ggcgatgttc accattatcg 969841 cggacgcacc cagctgaagc taagaaatat cagaccggta agcgagcaag aaaacgtcaa 969901 tattgatgat tttttagaaa ccgcgccgat tccgaaaaat gaaatgatgg ataccatcac 969961 tcaatatata tttgaaatga aaaatccgaa tatccagcga atcacaaggt ttttggttaa 970021 aaaacacgaa gctgagttta tggattatcc ggcggctacg aaaaaccacc atgagtttgt 970081 ctcaggtttg gcgtatcatg ttgtctctat gctgaacctg gcgaaagcaa tagcagattt 970141 atatccttct cttgatcgtg atctgcttta cgccggtgtt atcctgcatg atcttggaaa 970201 agtgaaggag ctgtccggcc ctgtttccac ttcatatacg gttgaaggca atttgctcgg 970261 ccatatttcc atcatggtga cagagctttc aaaagcggct gaggagcttc aaatcgattc 970321 tgaagaggtg ttaattcttc agcatttgat tttgagtcac cacggcaaag cagaatgggg 970381 cagcccgaaa ccgcctatgg tgaaagaagc ggaaattctt cactatatag acaatctgga 970441 tgcaaaaatg aatatgatgg acagagcgct tgagcgcgtg aagccgggcg agtatactga 970501 acgtgtattt gcactggaaa accgttcctt ttataaaccg acatttcata aataacttaa 970561 aaaggactga tgctgacata ttcagctcag tcctttttga tgcgtctttc ccgcacataa 970621 ctcgtctcat tcccgcatat ggttaagaat aaagaatcta tgcaaagggg gaggagcccg 970681 tgttattttt tccgtggtgg gtgtatcttt gtattgtagg catcattttc agcgcatata 970741 aacttgtggc ggcagccaaa gaggaagaaa aagtagacca ggcttttatt gaaaaagaag 970801 gacagattta tatggagagg atggaaaagg agcgagaacg ccgcagttct cagcagcatg 970861 aagaagaaaa tcaaaaccat tccatcgcat aaaaaaagct gtgcggctca atgagccgca 970921 cagctttttt tattatttag aattgcttga agatgaagaa gtgctgttgc ttgttgaaga 970981 tgtattaaat gtgtctttca gatctttatc ttttacttcg atgtcagcct tcttcatgac 971041 tttttgaaca gcttcctgaa cagctgcgtt gtcatttaat ttttgttcaa gcacttcaga 971101 tttcagttct tttttcatat catcatattt gccgcgttct tctgtctttt taatgatatg 971161 gtagccgtat tgcgttttga caggatcact gacttcacct gtttttaatt tgaatgcagc 971221 tttgctgaat gtttcgtcca tttggccttc ttttgcgaac cagccaagat ccccgccttt 971281 tgaagcagag ctgtctgttg agtattcttt cgcaaggtct tcaaacttct cgcctttttt 971341 cagctttttc tctacttctt cagctgtctt tttatcagca acaaggatgt ggcttgcacg 971401 gattttgcct tttaagcctt cccagtactc tttgatatcg gcgtctgtta ctttgatgtt 971461 atctttagcc gctttttgtg tcagcaattc atattttact tgttctttca ggtaatcttt 971521 gccatattgc ttttcgaggg cagtatattg atcgccaagc tgcgttttgt attctttcag 971581 cttgttgtca atttctttat ccgaaacttt atacttcttg tccaatactt tttcttgcac 971641 tagctgtgtc agtacgcttg cgccagctgt tttcttcatg tttgtgtaaa gctcgccttt 971701 tgtgacatcg cctgcgtctg tttttgcgat aacttctttg tcgccgctgc tgcaagcact 971761 gagagcgagg atgcttgtag cagtgatagc tgctattgcg attttcttca ttgttttcaa 971821 acactcctaa tcattccaaa ttaaattacc tatgcgtatc ataacatatt gtggctttct 971881 gtaaaaagat tttaaataaa gggcattcgt ctagtcaaac ttttgctgat gacatactta 971941 tatattgatc aagaaaagga ggtatgtaac atgagcggag gatactctaa cggattcgcg 972001 ttgctcgtag tactgttcat tttgcttatc atcgtaggtg cagcttacat ctactaagca 972061 gcccgaggat cgcttgcaac ataagcgatc ctttattttc actagcgcct aatcgtttca 972121 aacatgaatt gcataacatg taattggtaa ataaagctta ttacaggagg tgctatttaa 972181 gatgggtgaa gtatttgcag gcggattcgc tttattggtt gtgttattta ttttattgat 972241 tatcatcggc gcttcttggc tgtactaatc aacataaaaa agcatagctg cttaatcagc 972301 agctatgctt tctttcgtat ttacactgta aaggagatct ccacaaacga agagatcagt 972361 aaaattaata tagatacatt aataaatcgg aataccttat cttgccgctc ttcaggaatc 972421 tctctgacaa ggcataatgt attggtgagc ctgtttatga aatataaaat aaacacggca 972481 gccacgataa aatagaataa aatgatggga gattccccct ctctctgaac tgtcccatat 972541 tacattacca aatatttatt aaaaaagata gaatgcaaat tgaaaaatcg ccaccagcac 972601 cagggtttga ctacttttca acaagaatat ccaagccgtc agcttcctga tcaataaaag 972661 cggttttcgg tgcttttatc agcttgagag ccagcaggaa atcaggcaga cagtagccgg 972721 cgtgaatgcc cgagatcatg caaaaataat gagcgtgatt cggaaatgcc agtgctgcgt 972781 aaaacaatac cggtgtaatc agcaagaacg ggctgacgag tgaaatcagc attgttgttt 972841 ttggtatacg tttccatgtg cgcatgcgca atatgtaaaa ctttttttct atttttcttt 972901 ttttgcagat gattggcagg acatggatga ctttatgtac aaataaaata acgacgagca 972961 aaccgccgaa taaagataca tattcatcgc ttaagcttgt gccaggccgc agcagctcaa 973021 aagctaaaaa ggtagatata aaaaccaaaa tcataaaaca tacagcagtt aatattatgc 973081 gaacggcgcc ataatccttc atgagattta tggtcttcca gcaattcatc aaagtcatcc 973141 ttccatacat cttgaataga atctcaaaat aatttactcc tcccaagaga aaaaatcaat 973201 gcttttttaa gaaaaaatat catccggcag gtattttttt gaaacaagca aacaaactgc 973261 gaaatatggg gttagaactt tcttctcagt gaattatcag ctaaaataag attaaagata 973321 gaaagaagtg gtgtggatgg attcgatgga tcatcgcatt gagcgattag aatattacat 973381 acaattatta gtgaaaacag tagatatgga caggtacccc ttctatgcgc ttctcattga 973441 taaagggctg agcaaggaag aaggggaagc ggttatgagg atatgcgacg aattgtcgga 973501 agagctggca acacaaaaag cgcaaggatt tgtaaccttt gataagctcc ttgcgctttt 973561 tgccggacag ctgaatgaaa aattagatgt tcatgaaaca atttttgccc tgtatgagca 973621 ggggctttat caagagctga tggaagtctt tatcgacatc atgaagcatt ttgattaact 973681 gtttacaggt tcgagctctt cagccggttc atccgccgca ctgtcctttg cttttttctt 973741 caattttccg tttacgcttt caaagtcatt gtcaatattg gtgagtgacg tttcgaaaat 973801 ttccataaaa tcatcgccgt agatatggcg tatcatacac atcatttctg ccacttcagg 973861 aaattttccg aataaatgat ataaaggctg tgacccttta aaaacagcgt tgcgtgtcgg 973921 atcaaattcc tcaagcaagc tccagaatac ctcggtacct tcctcagtca attggacata 973981 tgtgttccgt ttatcattca gccgtttgga gaaccttaaa tatccccgtt cttccagctt 974041 ttttgaaaag ttgaatgcgg ttgatacgtg catgaccccg aatttcgcga tttcagaaat 974101 ggaagctcca ttcaattgat acgcaatcca taaaatatga tgctcattaa tattcaggtc 974161 atacggtttg agccattgct gccaatcctt ctcgatcgat ttccaaagag ccttgctaag 974221 ctgagccatt ttctgggtga aaaccagagc ttctttcaca tcatagggcg gttccactcg 974281 attcattacg tcacctgctt ctctttttct ttttctctat tatgccaata aaataaagat 974341 taataaagat gaaaatgtaa gaatttttta ataaattcac aaaccattgc gacgaaaggg 974401 tttttcggcc aaaaaaaata cgggtccaat tttggcccgc atttttttct tttgaatagg 974461 atattagttt tgtaaggttt tctccagctg tctgattttc tcttcgatat cggcaatttc 974521 tttttgcaga tcctgctggt gaggcttgat ctcttcctgc cattttttaa ttgatgtttg 974581 gagctcgccg cccacgtctt taataacatc cgtgctttct tttgccgctt tgatcagctg 974641 gtcttttaat gcaagcccgt ctgactttaa gcgtttgatt gtttcttcaa aagaatcata 974701 attggttttc attttttcac gcagctgctt tcctgaggaa ggtgcagtaa gaagaaccgc 974761 tgctcctccg atgatgccgc ctacgaatag tcctgttaat agagaacgtc cgctcgccat 974821 tacaatcacc ccgtcttttt cttcaaaata ggattcattc agcatttttc atttttgttg 974881 aaagcctgaa cttctataca tagcttgctt tattttagca tattttttaa gtgaaaagga 974941 gggagaaggt tgtctgtctt tttgattgta ttatcctgca tcacccttgc cttcgcttca 975001 ggcgctgttt actatatcaa acttctcagc caggctgctt cttatccgcc caagagggtt 975061 atccggcaga aagcgcttgt ttgttcaacc ggaaccgcct ttacactatg tcttatcttt 975121 ttcacaaaac tcctcgctta aaacatgctg acatgctgcg ggcgctctgt tcaaaaaaac 975181 ctctcccgga agcggaagag gttttgtgtg acaattattt agcagcttcc ataaagcttg 975241 aacgccttaa aatggtttgc acaatcggat aaataatgat cattgagatt gtattcagca 975301 cagcggccgg cagaacaaca gccgcgaaca atgcggcgaa accgcccggt aaaccgacga 975361 tcaataaagc tgacgataga aacacaattc ctgataagat ggtcccgatc actgtcagca 975421 cagcggctgc acctgttttc cggctctttc tgaacaagag aaacagggag aagaacagaa 975481 acgctgatac gggtttatca atgatgttag ggatctgtcc ggctggaaac gcggttgtaa 975541 gcgcggaaat gattccggtc acgatcccga tgacgagtac attttgcacc cgcgggaaca 975601 gcagaatgcc catgaacatc atgatcagca tcatatctgg tttcatgccg cctaaaaagg 975661 gcggaataat ggaatgaagc gctgcgccga ttgcggcaaa cagagccata atgactaact 975721 cttttgtttt cataactatg ctctcctctg ctaagctttt tgccctccaa taatatgctc 975781 atcatttatt gcgaaggctt tacagaatgt gttatgcaaa cagtatacca aacggacggt 975841 ttgcatagcc agacttttta ctcattttcc tgctggaatt tcttcatgaa cgcagctaat 975901 ttttcacagt cttcgagaga gaccgcgtta taaatagaag cgcggcagcc tcccaccgaa 975961 cggtgtccgc caaggccgat catcttcgca tcttttgctt tctgaacgaa tgttttcgtt 976021 aattcgtcat cccgaagcgt gaatgtgaca ttcatgcgtg agcggctgtc ttttctggca 976081 tgtcctttat agaagccgtt gctttcatca atacagctgt agagaacctg cgctttttgt 976141 tcattgcgct gttcaacagc ttccacaccg ccgttttcct tgagccattc cagaacgagg 976201 ctcagcatat aaatcgcaaa tgtcggcgga gtgttgtaga gtgaatccgc tttgacatgc 976261 gtggaatatt tcaagatttt tgggacgttc gcattttcat tttgcagcca gctttttttc 976321 atgatgacta cagtcacgcc ggaagggccg aggttctttt gggcgcctcc gtagatcaca 976381 tcaaatttgg acacatcgat ttttctgctt aaaatatcgc tggacatgtc ggctacgagc 976441 ggaattggag aattcggaaa ctcctgccac tgagtgccga aaattgtatt gttggatgtg 976501 atatgtaaat atgcgccgtc ttttacatcc gtaaggtcaa cctctggaat ataactgtaa 976561 ttgtctgttt cacttgtagc ggtgatagac gtgttcccga acagtttcgt ttctgccagt 976621 gctttttcag accaagcgcc ggtcatcaca aaatgtgcgg ttttttcagg tgttaaaaag 976681 ttcatcggaa gcattgagaa ttgaaggctt gccccgcctt gaagaaacaa gatatcgtaa 976741 tcttccggaa tgcccatcag ttcgattaag aggcttttcg ctttttggtg caccgcttca 976801 tactctttgc tgcggtggga aagctccata acagacatgc cggattcgtt aaaatcaata 976861 aattctttct gtgctttttg cagaacttcc agtggcagcg ctgcaggacc tgcgttaaaa 976921 ttcgttgtac gttccattat gatctctccc tgttttccac gttaatgtat aaaataatac 976981 aattatccta tcacaaaaat tcagtttttt gataaaaaat tagaattatc aaaagaaatt 977041 gacggatgtt tgcgaaatgt tcacaaaata aaataacctc atcttatgat gaggccaggc 977101 gttttgcgat agaggaagag atgttctgca gatcctccgg tttataatca tcagcatgcg 977161 ttttccaaac cgctccgaat ccatctcctt ttccgtagcg agggataata tgcatatggt 977221 agtggaacac agattgtcca gctttttcgc cgttattgtt cagcgtattt aagccgatcg 977281 gttcaaattc atcccggata gcgcgggcga tttttggaac agcatggaaa tattgttttg 977341 ctaattcatc tgtaaattca tatacattct caatatgtgt tttcggaatg acaagcgtat 977401 ggccttttgt cacttggctg atatcaagaa aggcaagtac atgttcatct tcatacacct 977461 tcgctgatgg aatgtcgccg gcaataattt tacaaaagat acaattctct gcacaatgca 977521 tgagggttcc tccttatgaa attgtttagt atgtatacat tcatcgtacc acagaaatgc 977581 agaaaataga aaacaggatg aacggcgagc gttcaccctg aatgcagagg aagagcttat 977641 atgaagaaaa tgtgttatgc ctttggtaag cacctcattt gtcaataaaa tgaagacttg 977701 tttaatgcct aacgattcct gcgataaaca cctcatttga caatttgctt catacatgaa 977761 gaattcatca attcagtgaa gagaaatggt ttgagcattg gacatgttta ttttctatcc 977821 aactgtttct aagacgtctt tgacaaacac ctcatttttc agttgatatg cttttcctct 977881 acaactttta tgatgtccag aaccctgtct ctttatgaca gcaaattcat catttgttaa 977941 aagggaattg tttcaaatca ggccttgttt ttggtactat gaagaaaaac actataaggg 978001 gagaaactat gtctctgcta tcggtaaaag acttgaccgg cggatataca aggaatccgg 978061 ttttaaaaaa cgtatcattc acccttgaac cgaatcaaat tgtcggctta atcgggctga 978121 atggtgctgg taaaagtaca acaatcagac acatcatcgg gctgatggac ccgcataaag 978181 gttcaatcga attaaacggt aaaacgtttg ctgaggatcc ggaaggctac cgttcacaat 978241 ttacctatat acctgaaaca cctgttttat acgaagaatt gacgctgatg gagcatcttg 978301 aactaacagc catggcatat ggactgtcaa aagaaacgat ggagaaaagg ctgcctccgc 978361 tactaaagga attccgaatg gaaaagaggc tgaagtggtt cccggcccat ttttctaaag 978421 gaatgaagca gaaggttatg attatgtgcg catttttggc agagcctgcg ctctacatta 978481 ttgatgagcc ttttctaggg cttgatccgc ttgccattaa cgcgctgctt gaacggatga 978541 atgaagcgaa aaaaggcggg gcgagcgtgc tgatgtcaac acacattttg gcaacggcag 978601 aacgctattg cgattcgttt attattttac ataacggcga ggtgcgggcg cgcggcacgc 978661 tgtcagagct cagagagcag tttggaatga aggacgcggc gctggacgat ttgtatcttg 978721 agcttacaaa ggaagacgct ggccatgaat aatatgcttg atatttggca gtcgcggctg 978781 caggagcata tcaaagaaac aagaacatac atgaaatata tgctcaacga tcacctcgtc 978841 attgttttga ttttttttct agcgggcgct gcaagctggt acagcaaatg gatacgggac 978901 attcccgctc actttccgtc cttttgggtg atggccgtgc tgttttcgct cgtattgaca 978961 agctcttatg tgcgaacgct tttgaaggag gctgaccttg ttttcttatt gcctcttgaa 979021 gcaaaaatgg agccttactt gaagcaggcg tttgtctaca gctatgtgtc tcagctgttt 979081 ccgctgattg cgctgagcat cgttgcgatg ccgctttatt tcgcagtcac tccgggagct 979141 tcgctcgtat cgtatgccgc ggtctttgtc caactgttgc tgctgaaagc gtggaatcag 979201 gtaatggaat ggcgaacgac tttccaaaac gaccgcagca tgaaacggat ggacgtcatc 979261 attcgctttg cggcgaatac actcgttctt tattttgttt tccaatctgt ttatatgtat 979321 gcgcttctcg tctatgtcat tatggctgtt ctttatctgt atatgtcttc cgcagcaaaa 979381 cggaaaacat ttaaatggga gagccatatt gagtccgaat tgagacgaaa gcagcgtttc 979441 tatcggattg ccaacctgtt tactgatgtg ccgcatttgc gaaagcaagc caaacgcaga 979501 gcttatctcg actttttgct gcggcttgtg ccgtttgaac agcgcaaaac atttgcctat 979561 atgttcaccc gcgccttttt gcgttcgagc gattatttgg gcattcttgt cagattaacg 979621 atcgttttcg cgctgatcat tatgtatgtc tcagccagcc cgctgattgc cgcggttttg 979681 actgtgtttg ccattttcat tacgggcatt cagcttctgc cgctcttcgg tcactttgac 979741 catctggcgc ttcaagagct gtaccctgtg caaaaagaaa caaagctgaa aagctatttc 979801 tctctattaa aaactgcact tagtattcaa gcgctgctga tgtctgttgc atctgcctat 979861 gcagccggct tgaccggttt tctgtacgcg ctgatcggtt ctgccgttct gatttttgtt 979921 gttttgcctg cttatatgac gaccaggctg aaaaagcacg gaaagctgtg aactgaaaag 979981 aggtaatcaa atgacagata atcagctgct gatgcaggaa gctttggaat ggaaaatgca 980041 ttttttgcga aaggattcca tgtttgaacg cttttcgaag cgtgtccaga cgaaggtgaa 980101 tgaacggatt cctgaaaaaa tccatacggt cgtcaccgag agtgtgaaaa aaatggtaga 980161 agcgacaatg gccggctcta atatcatcac ctataaaaag gatacaagtg cactgtcgct 980221 cagtgaaaaa aacgaattgg cgaaaaaaac gattgtttct tatcaaaaag tggcagctgc 980281 tgagggagtc ggcaccggag cgggcggcat ttttttaagc attgctgatt ttccgctgct 980341 gctttcaatt aagatgaagt gtttatttac cttgtcttcc atttacggct ttgatgtcaa 980401 ggatgcacaa gaaaggatat ttttgctgct cgtgtttcag cttgcgtttt cgagtgatga 980461 tggccgtaag tcgctttttt ctgtcatcga aaattgggag acggagaaaa agagcatcga 980521 ctggagagtg ttccagcagg aatatcgcga ttatatcgac gtcgtgaagc tttttcagct 980581 tttgccgggc gtaggagcgg cagtcggcgg aattgccaat tataagctgc ttgctcagct 980641 tggagaaacg gcaagacatg tttttcatct gaggatatta aaggaaacag ccggagaata 980701 aacactccgg ctgttttttt atagctgatg ataggtgatc gcagcgccgg caaggacctt 980761 ggccgctgtc agcatggctt tttcgttgat atcaaatttc ggatggtggt gggaatagac 980821 tcgctctggc tgttcgggag cggcgcctgt aaagaaaaaa gtgcccttca cgttttgtaa 980881 gtaataagca aaatcctcgc cgcccatttg tggttcaccg tcaatgacct gctgaacgcc 980941 ctcggtattc tttgcggtgc tcaccaagtg gttcgtttct gcaggatggt tcacaaccgc 981001 tggataaccc tgttcatagg tgtactcata ggacgcgccg tgcatgctgc atattccttt 981061 tacaaccgct tcaatttctt tctccagaat gtcccggaca ttttcatcaa aagaacgcgc 981121 tgtgccgatg agtactgctt ggtctgcgat gacattaaac ggattgtcgg cgatgaagga 981181 gcctgtcgaa atgacggcgg attgaatcgg attgactttg cggctgacaa tgtgctgcaa 981241 agaggaaacg atttgcgaac cgattaggac ggcgtcttta gtatcatgcg gatgagcgcc 981301 gtggccgccc tttccgaaga ctttaatcgt aaatcggtct gccgccgcca ttacggcgcc 981361 ggggcggcag agaatagttc cgagcggctc agttgcccaa agatgagtgc cgaatatcac 981421 atccgtgttt tcgagacatc cgtcatcaat cattggcttt gcgcctccag gataatattc 981481 ttctgcatgc tggtggatca tcacaaatgt tcccttcagt tcatgtctgt tttggtgaag 981541 gaccttggcc actgcgagaa gagctgcggt gtggccgtcg tggccgcatg catgcatgac 981601 accaggcact ttggaggcgt aagggacatc tttttcatct tgaatgggga gagcgtcaaa 981661 gtcggccctc aaagcgactg tagggccggg ttcgcttcct tctatatttg ctaaaacccc 981721 tctaccgcca acgtttgtgc ggattgggac tcctaacgat tcataatagg aagcaataaa 981781 tgcggcggtt ttttcttctt gaaatgagag ctcaggatac atatgaaaat ggcgcctgat 981841 ctcaaccatt tcttcaaaac agccgtcgag ctgtttgttt atctctttct gcagtgtgga 981901 tatggacaaa gccgcttccc ccttttctat gcttttccat gattgtatag aaaaagtctg 981961 aatatttcaa ctcatgctgt tttaaagcat catcacagct gcgagggttg tcaccaaaag 982021 gccaatcgcg acgggaatga agttttttct ggcaagctca aaaggatcaa ctttgcaaat 982081 ggccgcggcg ggaatcaaag cccatgggac cagtgttcct ccgcccaccc agatggcaga 982141 gatttgtccg agcgcggtca gaatagcggg atcggcatgg agagcggacg aaaagagctt 982201 tgcgatggag ccggcgagag aaatgccaga aaatcctgag ccgtcaaggc ctgttatggc 982261 tccagcggca gttaatgcag tggcggcaag ctcctttgac ataggcatca tatgggataa 982321 agcaatgcca agatcgttga caatgccgtg ggaaccttta gggagtgaag tgcccagtat 982381 gctttcatag cctgagtcgc caagataaaa gaaagcggca atcgggatga cggggccgaa 982441 aaccttaaaa ccgaacttaa atccgtcaat aaaatagccg gtgatttttt caagcccttt 982501 atgcttatac acgaaaaaat gaacggtaaa gaggatacaa attgcagacc cgccaattaa 982561 cgcggttgca tcatttcctt gtaggttaaa caagagcatg caggcgatat ctgcaagaaa 982621 ggcaagcgga atcaaaaaag ccagtatgga ccgcaggcgt tttggcaagt acagcgagtt 982681 gtcttgttcg ccggaaagaa cgggggaaaa agaagtggga tgctcctgtt ttttgcgttc 982741 gcgctgaatc atgataaagg cagcagttgt tgttgtcaca cccataatca gcacaagcgg 982801 aatactggcc gagacgacat caccgactgg aatgcctgct gcatccgcag tcagctttgg 982861 cgccgcctga atgacaaagt ctcctgacag ggcaaaaccg tgtccgaata agttcatggc 982921 catggccgcg gcaagaggcg tcaaaccggc acgtgcggct gcggggagca ggacggcgcc 982981 gatcaaagcg acacccggag aaggccagaa gaatagagaa atggcgaaca tcaggcctcc 983041 aatcagccaa taggcagtca caggccctct cacaaggctt gcaaagggag aaatcatcgc 983101 ttcatttatc cctgtttttg ttaacaaatc actcattgaa acgataaagc aaatgatgaa 983161 aatcgtgggc agcagttcgc cggccgcata gataaagctg tggaataaac tgctgacaga 983221 agctgaaagt gaatggctgg cccatagcga tatgataaaa atgccgaata gagaaataaa 983281 tgtcgtgtct tttctcagca gcataaatag gataattgca ccgataaaaa acacatacag 983341 aacatggaca ggcaaaatcc cgacttccat catcgatcac tccttccgct tacagattat 983401 tcataggcgg gcggaaggtg ccgggacaga ggggagggtt atgatggaag atgaacattg 983461 atctgtttca gctgctcaat cagatgatgc cttaatcctc tattcgcttt ttgcagatgt 983521 tttgggaagc attcaggaga aaaaatgacg cacccttcag caagccagtt ttttctatag 983581 gcgatgatgc tttccgatgg ctctatatga gttatcctcg tgctgcatct cgtactcatc 983641 aaatccgaac tgaaaaccgc agcacgggca gatttcatga gaatgattgc cttcatgatc 983701 atatggcggt tcagccaatc cttaaacccg cagactgggc aagtatgctt cattttgctt 983761 tcctcccaat aaaataagct gccggacatg ccggcagcta ttcgacagcg aaatatgtgg 983821 tgacatagga aggccgggag aagatcgacg ttgtgtcaat tccggcagat gtatcgcgtt 983881 ttttgtgggc ttctttgtaa gaaccggact gctgccagtc ttgaaaggcg ctttccgttt 983941 cccacaaggt cagaatgaca taggtgtcac tgtcaagcgg acggagcact cgaattgctt 984001 caaagccagg ctcgttttcg acttttcccg ctctgttttt aaatctgttt tcaaacagcg 984061 gacgcccttc ctgagtaacg gcaatattgt tcaatactgc aaaaccggga tgtttgatct 984121 ctccgacttg gtcaatgact tcataagcgt gtggtgcctg gaaaacggta tctccgtttg 984181 tttcatgaat taaaatggcg ttttcctgcc cctgcatcaa aaggatattt tctgagggat 984241 gcttctgtac gatcgttttt aaaaaatcgg ctgtcccata tgtaatataa accttcatat 984301 cagccacctc ctgcttgcta gtatatcaaa acaatggtat aagtttctat tggcgagtgc 984361 ttcgaacata attccaaaca atttttccca tactaccttt agaaaggcga ggtgagttca 984421 tgtttaagat aaagaaaaag aaacttttta tacctatcat tattttagtg ttaactgctt 984481 ttctcgcttt aataggatat atttcaatta tttttctcgg ccattatgtc atagatgaaa 984541 aaaagcttat tcttcatgct tcttcaaaaa ttgttgatca aaacggagat gaggttgcaa 984601 gcctgtatac agaaaatcgc gagccggtct cgatcaatga gattcctaag caggtcagag 984661 aagcgtttat cgctgttgag gataaaaggt tctatgagca tcacggcatt gatgcaaaat 984721 ccgtcggaag ggcagtgtac cgcgatatat tagcaggcgg aaaggtggaa ggcggaagca 984781 cgatcaccca gcagcttgcc aaaaatattt ttctgacaca tgacaaaaca tttctaagaa 984841 aaacaaaaga agtgatcatt gcgattaatc ttgaacggga ttacagcaag gacaagctgc 984901 ttgaaatgta tttaaaccag ctttacttcg gacacggggt ttacggcata caagcggcgt 984961 cccactatta ttttaataaa gaagtaaaag atttgactgt atctgaaggc gctgttttgg 985021 ccgctattcc gaaggcgcct tctacgtact ctccaatttt gcaccctgat aaaaataagg 985081 agcggcgtga tacaattcta ggtatgatga atgaccaagg ctatatcagt gcgaaagagg 985141 ctgtcaccgc acagggccgg acgcttggac tgcatgtgaa gaaacagtcg gaaacacctt 985201 ggtttgacag ctacattgac cttgtgatca aagaggcgga agacaagtat tccatttccg 985261 gagagcagct tcttcaaggc ggatacacga tcaaggtgcc gctcgattcg aagctgcaga 985321 agacggctta ccaggtgatg aaagagggaa gctattatcc cggaacagat cagaatgccg 985381 agggaagcgc ggtctttatt aataacaaga caggcggtgt agaagcggcc atcggcggaa 985441 gggattacac atccaaagga tataaccgtg tcacagctgt ccgccagccg ggttccacat 985501 ttaagccgct tgctgtatac ggaccggcga tgcaggaaaa gaaatttaag ccatattctc 985561 tattgaagga tgagttgcag tcctacggag attatacgcc gaaaaactac gacagccggt 985621 atgagggcga agtcactatg tctgacgcca ttacgtacag caaaaacgcg ccggctgtct 985681 ggacgctgaa tgagatcggc gtcgaaacag ggaaatctta tttgaaagca aacggcattg 985741 atatccctga tgaaggcctt gctcttgctc taggcggctt ggaaaaaggc gtttcaccgc 985801 tccagcttgc cggcgcgttt catacatttg ccgcgaatgg aacgtatact gaacccttct 985861 ttatctcgag cataatagat gaagacggag aaacaatagc cgatcataaa gaagaaggaa 985921 agcgggtatt cagcaagcag acgtcttgga atatgacgag aatgctgcag caggtagtca 985981 aaaagggaac ggccacgtcc ggcacctatc acggcgacct ggcgggaaaa acaggttcaa 986041 catcttatac aggcgtctcc ggcgcgacaa aggacgcctg gtttgcaggc tatacgccga 986101 aaataaccgg ggcagtctgg atgggctatg acaaaacgga tcaaaaccat tatttgaaag 986161 ccgggagctc atacccgacg cggctgttta aggatatttt gacacaggca ggagaaaccg 986221 gtcatgtgtt cacaaagcct aaaaacgtta aagaactgga aagcccgatt gagctgaagc 986281 cggtcaaaac actcacagcc gattacacat ttaaagcagc ggggctcttt actattgaat 986341 taaagtggga cgctcaagag gatgatcggg ccgtatacag aatttatgta aacaaggacg 986401 gcgaggagac gcttcttgat tcggttgaag ggaagggaag ctatgaaatt ccttatgcca 986461 acttattttc gggcgcgtct tataaaattg tgccttataa tacacagaca aaaagagaag 986521 gggaaggaac cgattacgtt cagccaaaat tgttttcctc ttaatggaat tcggcgattt 986581 tttgaacttt gagctacatt tctataccat ttgcctaaaa caaggtatag tgtaataagt 986641 caagaaatac gaacgtatgg ttgccgtatg aaaggtggaa atcagatgag taaacgagaa 986701 acgtttaacg agacgttttt aaaagctgcg cggggagaaa aagcggatca cacgcctgtg 986761 tggtatatga ggcaagcagg gcgctcacag ccggaatacc gcaagctgaa ggaaaagtac 986821 ggattgtttg agatcacaca tcagcccgaa ctttgtgcgt atgtcacaag actgccggtt 986881 gagcaatacg gagtcgatgc tgcaatcctt tataaagata tcatgacgcc gctgccgtca 986941 atcggtgtgg atgttgaaat caaaaacggg atcggtcctg tgattgatca gccaatccgg 987001 tctctggcgg acattgaaaa actcggccag attgatccgg aacaggacgt gccgtacgtg 987061 cttgagacga ttaaactgct tgtcaatgag cagctgaacg tcccgctcat cggtttctca 987121 ggtgcgcctt ttacgcttgc aagctatatg atcgaaggcg gcccgtcgaa aaactacaat 987181 aaaacaaaag ccttcatgta cagcatgcca gatgcatgga atctgctgat gtccaagctt 987241 gccgacatga tcatcgtgta cgtgaaagcg cagattgagg caggcgcaaa agcgattcaa 987301 atctttgatt cgtgggtcgg cgcattgaat caggcagatt acagaacata catcaaaccc 987361 gtgatgaacc ggatcttttc agagctcgca aaggagaatg tgccgctgat catgtttggc 987421 gttggcgcaa gccatcttgc aggtgattgg catgaccttc ctctcgatgt tgtcgggctt 987481 gactggagac tcggcattga tgaagccaga tcaaaaggaa ttactaaaac agtgcagggc 987541 aacctggacc cgtccatttt gcttgcgcca tgggaagtca ttgagcagaa aacgaaggaa 987601 atacttgatc agggtatgga gtcagacggc ttcattttca atcttggcca tggggtattt 987661 cctgatgtca gtcccgaggt tttgaaaaaa ctgacagcat ttgtccatga atattcacaa 987721 aacaaaaaaa tgggtcaata ttcctaagca tatcttttgg tatcttaatg atatcctgtc 987781 aaaatgtttg tatcagatca ttaaagaggg tgtaaacagt gagtagaaag aaaatggggc 987841 ttctcgtgat ggcgtacggc acgccttata aggaagaaga tattgaacgt tattatacac 987901 atatcagaag aggcagaaag cctgaacctg aaatgcttca agatttgaaa gacagatacg 987961 aagcgattgg cggcatttca ccgcttgccc aaatcacaga acagcaggcg cataatctgg 988021 aacagcactt gaatgaaatt caggatgaga ttacgtttaa agcgtatatc ggactgaagc 988081 atatcgagcc gtttattgaa gacgccgtag cagagatgca taaggatggc attacagaag 988141 cagtcagcat cgtgctggcg ccgcatttct ccacgttcag cgttcagtcc tacaacaaac 988201 gcgccaaaga agaggctgaa aaactcggcg gcttaacgat tacgtcagtt gaaagctggt 988261 acgatgaacc gaagttcgtg acatattggg ttgaccgagt gaaggaaaca tatgcgtcaa 988321 tgcctgagga tgaaagagaa aacgcaatgc tcatcgtatc cgcacacagc ctgccggaaa 988381 aaatcaaaga atttggagac ccgtacccgg accagcttca tgaatcggcg aaattaattg 988441 ctgaaggcgc aggcgtttcc gaatatgctg tcggctggca aagtgaaggg aacacgcctg 988501 atccttggct cggacccgat gttcaggatt taacacgtga tttattcgaa caaaaaggct 988561 atcaagcatt tgtatatgtt cctgttgggt ttgtcgcgga tcacttagaa gtgctttatg 988621 ataatgatta tgaatgcaaa gtggttactg acgatatcgg cgcaagctat taccggccgg 988681 aaatgccaaa tgccaagcct gaatttattg atgctttggc aacagtcgta ttaaaaaaat 988741 taggacgtta aagaaggcga tgaacatgag tgacggcaaa aaacatgtag tcatcatcgg 988801 cggcggcatt accggtttag ccgccgcctt ctatatggaa aaagaaatca aagaaaagaa 988861 tctgccgctt gagctgacac ttgttgaggc aagtccgaga gtcggcggga aaatccagac 988921 tgtcaagaaa gacggctata tcatcgaaag agggccagac tcatttctgg aacgaaagaa 988981 aagcgccccg cagcttgtta aagacttagg tcttgagcat ttgcttgtca acaatgcgac 989041 cgggcaatcc tatgtgcttg taaaccgcac cctgcatcca atgccgaagg gcgctgtaat 989101 ggggataccg acaaaaattg cgccgtttgt ttctacgggt ctgttttcct tgtccgggaa 989161 ggcgagagct gctatggatt tcatcctgcc tgcaagcaaa acaaaggatg atcagtcatt 989221 gggagaattc ttccgcagac gtgtcggaga tgaagtggtc gagaacttaa tcgagccgct 989281 actatcaggg atctacgcag gcgacattga caagctcagc ctgatgtcga catttccgca 989341 attttatcag acggaacaaa agcatagaag cctgattctc ggcatgaaaa aaacaaggcc 989401 tcaaggctca ggccagcagc tgacggcaaa aaaacaaggg cagttccaaa ctctgtcaac 989461 cggtttgcag acccttgtag aagagatcga aaagcagtta aagctgacga aggtgtataa 989521 aggcacaaaa gtgaccaaac ttagccatag cggctcttgc tattcgctcg aactggataa 989581 cggcgtcaca cttgatgctg attcagtaat tgtgactgct ccgcataaag cggctgcggg 989641 aatgctttct gagcttcctg ccatttctca tttgaaaaat atgcactcca catccgtggc 989701 aaacgtcgct ttaggtttcc ctgaaggctc cgtccaaatg gagcatgagg gcacgggttt 989761 tgtcatttca agaaacagtg actttgcgat cacagcctgt acgtggacga ataaaaaatg 989821 gccgcacgca gcgccggaag gcaaaacgct gcttcgggca tatgtcggaa aagccggaga 989881 cgaatccatt gtcgatctat cagataatga cattatcaac attgtgttag aagacttaaa 989941 gaaagtcatg aacataaacg gcgagccgga aatgacatgt gtaacccgat ggcatgaaag 990001 catgccgcag taccatgtcg gccataagca gcgtatcaag gagctgcgtg aagcacttgc 990061 atctgcgtat ccgggtgttt atatgacagg cgcttctttc gaaggtgtcg gcattcccga 990121 ctgcattgat caaggaaaag ctgccgtgtc tgacgcgctt acctatttat tcagctaaaa 990181 cctccgcttt atcgcggagg tttttttgat gtgcaatggc aatattgtgt aaaaaatgat 990241 tgaattgaac agcaggttat gatacatttg catatgtact taatgactaa aatgttcaaa 990301 cggtcagttt cgaggtgaat acaatgtcaa tagatcgaaa aaagctcatt ttggaggcgg 990361 ctacaaagtc tttcacgcag ttcgggtata aagcgacgac aatggatctt gtcgcaaaac 990421 ttgcgaacgt ggggaaggga accatttata cttttttcaa aaacaaagaa gagctgtttg 990481 acgagatttt cactacttta ttaaaggaaa tgaagcaaaa agcggatgaa gcgatggagc 990541 cgagccttcc gttccatgaa aatgtgcaca gagcgctgtt tgccattctg gagttcagga 990601 aaacacatca gctgacgatt aaaattttcc aagagaatgc cgagattggt acaatggcag 990661 ttcaggaagt gatccagaaa atggagcgat ccatcctgtc ttatatcaaa agcaagattg 990721 aagacgggat caaaagcggc gcaatcaagc cgtgcgaccc tgagctgaca gcctttgtga 990781 tgctgaagct ttatatcgcg ctcatttttg actgggaaaa acaacacccc ccgcttgata 990841 aagagacaat tgcgggactg cttgaattgt atgttgtcaa aggattgtca gcgaactaga 990901 taatcctttc tctttgcaag aaaatgacca ttttttatga tgagtcagtt ttagaatgga 990961 ggcatcagga tgaacacaat acgaagtcag tggaaagaca tcgtaacaag taaaaaatta 991021 ttgattccca tcatcgccat tttgtttgtc ccgcttattt acagcggcgt attcttaaag 991081 gcttattggg acccgtacgg cacagttgac cagctgcctg tcgttgtcgt caaccaagac 991141 aagggagcaa cgtatgaagg agaaaaactt caaatcggtg atgatctggt caaagaatta 991201 aaggataata acaactttga ttggcatttt tccaatgatc tcgaccaatc gttaaaggac 991261 ttattgaatc aaaaatatta tttagttgtc gagattcctg aggatttttc taagaatgcc 991321 agcactgtat tagacaaaaa tccgaaaaaa ttggatctga aataccatac aaatgcaggt 991381 tctaactatg taggggcaac gatcggcgaa aaagcgattg ataaactgaa agcctctgtt 991441 tcaaaagaag tgaccgagca atatacgaaa gttatttttg ataactttaa agatatcgca 991501 aaaggtttga gcgacgcgag cagcggcgcg aaaaaaattg atgacggcac aaaggatgcg 991561 aaaaacggaa gcgcccagct gaaagaaaat ctggcgaagc tgaaggaaag caccgctacc 991621 atcagtgaca aaacagcgca gcttgcagat ggagcggctc aggtgacgag cggcatccaa 991681 tcacttgaca gctcgctcgg taaattccag gacagcagca accagattta tgataaatct 991741 agtcagcttg cagcaggatc aggcgagctg acaagcaaga tgaatgaact tcttgccgga 991801 cttcaaaatg tgcagaaggg tacgcctaat cttactaacg ggttggatca gctcaacagt 991861 aaagtccaag aaggttctga gaaagcggca aaagcggaaa agatcattaa tgcgctcgat 991921 ttaacgaagc ttgaaactgc tgtaaacaat ctggaaaagt cagaaactgc gatgaaggaa 991981 ttcaaaaaac agctgactga ctttgaaaac agtttgaaaa accgtgatca ggcatttaaa 992041 aatgtcatca attcgagtga cttcttaaca gcggagcaaa aaagccagct gattaattct 992101 gttgagaaaa agcttccgca agttgatgcg cctgattttg atcaaatatt aagccagcta 992161 cctacagctg atcagctgcc tgacatcgca acgataaaaa gctctcttga agacgtgaaa 992221 gcgcaggtgg cgcaggtgaa agccatgccg gaagctacat ctaagcttta taacggcgca 992281 aaaacaatcc aagatgcgat tgacagatta actgagggag ctgataagat atacaacggt 992341 tctcagaagc tgacagatgg ccaaactaaa ctgacagcgg gcatcggtga atataataag 992401 cagttcgcaa aagcaaaagc gggctcagag caattggtga caggaagcag ccaagtatcc 992461 ggcggattgt ttaagctgtt agacgggtct aaacaggtcc aaagcggatc atcaaaactt 992521 gcagacggat ctgcatcact tgatacaggt ttaggcaagc tattggacgg cacaggagag 992581 ctgtctagta agctgaagga tgcggctgac caaacaggag atatcgatgc tgatgatcaa 992641 acatacggca tgtttgcgga tccggttaaa accaaagatg atgccattca ttccgttcct 992701 aactatggaa cagggctgac accttatatc ctgtcaatgg gcttgtatgt cggcggcatc 992761 atgctgacgg ttgtcttccc gctgaaggaa gcgtcaggac gtccgagaaa cggttttgag 992821 tggttcttca gcaaattcaa tgtcatgatg cttgtaggaa tcattcaatc attgattgtg 992881 gcgacggttc ttctattggg aattggtctt gaggtagaga gcacgtggag attttacgtg 992941 tttacgatca ttacgagtct cgctttcctg gcgataattc aatttttggc tacaacgatg 993001 ggcaacccgg ggcgatttat cgcagtcatt attttagtgc tgcagctggg agcgagcgga 993061 ggaaccttcc cgctggaatt gcttccgaat ttctatcagg tcatccacgg cgcattgccg 993121 atgacctaca gcattaacgg attcagagca gtcatttcaa acggtgactt tggctacatg 993181 tggcagatgg ccggcgtctt aatcggcatt gccctcgtca tgattgcact aagcattact 993241 tactttacaa tgttaagccg gaaggaagaa acatcagaag aacagccggc ttcataaaga 993301 aaaagaactt gtttccttgg aaacaagttc tttttttgtt acatccccca tttaataagc 993361 aatcctgtat aggttaatcc gccgccaaac ccgaaaagca aaacgatttg atcttttttc 993421 agcttcccgg ctttcactgc gagatcgagc gccaaaacaa ttgaaaccga agacgtgttt 993481 ccgtagtgct caacactagt gagcgttttt tcaatcggga acggtgtttt ttcacaaatt 993541 gactcgatca tgcgcaagtt ggcgctgtga ggaacaaacc aatcgagatc atcggagctg 993601 agtcctgctt tatgtaaaag ccgttcaaat tcgccaggga cggttcttgc ggcccattta 993661 tatacctcgc gtccgttttg caccattttt ccggaaccga caagctgcac accgtttatt 993721 tcatttcgca gtccggcacg atacaaaata tcgccgccgt tcccgcttgt tccttgtaca 993781 gacgcaagaa atcccggcgt ctcttcatct cgttctacta acagcgcacc cgcggcatcg 993841 ccgaacagta cgcatgtcgt tcgatcggta taatcggtta cctttgataa cgtctctccg 993901 gcgatgacga gaattttttg atgaaggcca gatgtgatca atccatttgc caaatggagg 993961 ccgtatgtca gcccggcgca tgtcgcatta atatccagcg cgccggtgct ttcccagccg 994021 aaatattcct gtacgcggca tgccgtactc ggaaaggcgt aatcggatgt ggttgtggca 994081 acgaggatca tatcgacatc atcaagcgtt cctttataac ggctcttgag attcttcacc 994141 gcttctatgc ataaatcaga ggtaaattga tgttcatccg caatccggcg ttctctcatt 994201 cctgtgcgct gaacgatcca ttcatcagag gtatcaacga tcttttctaa atctgcattg 994261 gttaaacgtc tgctcggcgc ataggtgccg atagctgtaa tttttgcttt tgacatatga 994321 atcactcctt atggtcagat tataacacta gatattagta tctggtacta aaaagaaggt 994381 ttttttacaa aaaaagagaa gtgtagatag gaatctatga aaaagaaaaa ggaggctgaa 994441 aaatggtcag tcaagaagca gtagtctttt tggcattatc cggggctatt gcgtttctgt 994501 tgccaatcgg gctgattgta tggtttaagc gaaagtatgg tgcctcgctt aaagtgtttt 994561 ttattggcgc tctcacgttt tttgtcttcg ctcagctgct ggaaggcggc gttcatgttt 994621 atgtactgca agtgaatgaa atgacgaaag aagcgatgca gcatccatta tggtatggca 994681 tttacggctg cttgatggcc ggcatttttg aggagtgcgg aaggtatttg atgatgcgat 994741 tttttatgaa gcgccatcat acttgggcag atggtctggc tttcggggca ggccatggcg 994801 ggcttgaagc catcctgatt acaggcttgt cctctatctc acttattgta tacgcatttg 994861 caatcaatag cgggacgttt gaacagcttt tggtcaatgg cgacgtcaaa caggcgcttt 994921 tgccgataca ggagcagctg ctgcatactc cttcgtatga atggatgctg ggcggaatag 994981 aaagaatcag tgccattgcc gtccagattg gtctgtctct gcttgttttg tacgcggtta 995041 aaaaccgccg gccgctgttt ttgctgtatt ctattctttt acatgcactg tttaatgtcc 995101 cggcggtttt atatcaaaga ggaatcatag agcatgctgc agctgttgaa atcattgttg 995161 ctcttatagc ggctttatca gtttattgga ttgtaaaagc aaaaagggtg tttcaataaa 995221 aggtccaagc agcagcaatg cccgcttgga aaaatgtgaa tggaaatatt cattaagcat 995281 gggtcatcag aatatttctg attcagtctt tagcaatgac agcaagaatg tctgtgtttt 995341 ttacaagaga aacaatggtg tttctttttc ttcttctcgc aagggtcatg gcattctttc 995401 tttttcttgc aatggtcgtg gaaatcttta tcgaaccact cgtcaaagaa ccaaaaatca 995461 tcgaaccaat cgtgacaacg acatttctgt tcatgtgaat gacgacagca catagaaatc 995521 cctcctcttc ccatgctctc tacagcatat gagagattga taggaaaaga ttggacgggt 995581 ccctcgggaa aagagtatat tttaagtaga aaataaaagg aggaatgccc tatgacgtcc 995641 gtacgtaaaa cgatggagct cattaaagaa cttgtatcga tcccaagccc gacaggaaat 995701 acatatgagg tgatcaatta tattgaaagc cttttaaaag aatggaaggt agaaacggtt 995761 cggaaccaca agggcggctt aattgcaacg cttccaggac gcgacacatc ccggcatcgc 995821 atgctgacag cgcacgttga caccctcggc gctatggtga aggaaattaa agcggacggc 995881 cggctgaaaa tcgacttaat cggcgggttc cgctacaact cgattgaggg ggagtattgc 995941 caaattgaaa ccgcctcggg aaaaatgtac acaggcacaa tcttaatgca tcaaacgtct 996001 gtgcacgtat acaaagacgc gggaaaggct gagcggaatc aagagaatat ggagatccgc 996061 ctagatgaac ctgttcactg ccggaaagat acggaggagc ttggcattgg cgtcggagac 996121 tttgtgtcgt ttgatccacg tgtcgagatc acatcaagcg gatttattaa atcgcgccat 996181 ttggatgaca aagcaagcgt cgccttattg ctccgcttaa ttcatgaaat tcaaacagaa 996241 gacattgagc tgccgtatac aacccatttt cttatttcca ataatgaaga aatcggttac 996301 ggcgggaatt cgaatattcc tcctgaaaca gttgaatatt tggcggttga tatgggcgct 996361 atcggtgacg ggcaggcgac ggatgaatat tcagtatcaa tctgtgtgaa ggatgcgagc 996421 gggccgtatc attatcagct cagaaagcat ttagttcaat tagccgagaa gcatcatatt 996481 gactataagc ttgatatata tccgtactac gggtctgatg cgtcagcagc gatcaaatcc 996541 gggcatgata ttgtgcatgg cctcataggg ccgggaattg acgcttccca tgcatttgaa 996601 cgcacccata aatcatctct tcgccatacc gctaagcttc tgtattacta tgtacagtca 996661 ccaatggtat aagggggagg accaatgaag atttataagc tgaaaagcac attcggttgg 996721 gaaggtgatg acgggttggg agaacagctg attcagcaga tccttgccgg agaaaaaagc 996781 gccacgtgcg cgccgaaatc attgtattca aaagatgaat tgagggacgt ttatcaaaca 996841 gcgggtcagc ttgttaccgt ttatgataaa catgacaatc caagatgcaa tataaaagta 996901 acagatgtct ttgaaaccac ctttggtgcg cctgatatga ggttagtcaa aggagagggc 996961 aatggagacc gaattgagga gtttcaagag gatcatcgga tggcatgggc ggaactgatc 997021 aaaagcggtg aactggagct gaatgaggat actgttttga ttacagagtt gtttgtgctt 997081 gttaaagatt aaaaaagcct gcggggcaag aaccccgcag gcttttcatt aaccagaaat 997141 ggttgcgttt tgttctgttt tcgattggga cataacagtt tctgctttcg caggattaaa 997201 catgccttcc catttagaca tcacaacggc agcaagcgcg ttaccagtca ggttgacaac 997261 tgtacgtgcc atatccatga tgcggtctac gccggcaata aaggcaagtc cttcagccgg 997321 aacgccgatg gtgccaagcg ttgcaagcaa gacaacaaaa gaagtaccag gtacggcagc 997381 catccctttg gatgtcacca ttaagacgag cacaagcgta atttggtgcc aaatcgtcaa 997441 atcaatgcca tatacctgtg ctaaaaagag tgcggcaata gattgataga gaacggaacc 997501 gtctaagtta aacgtgtaac cgatcggaat gacaaatgaa acaatgcctt ttggacatcc 997561 gattttctcc attttttcca tgatacgcgg aagaaccgtt tcagagctgg acgtactgaa 997621 cgccagtaag atttcgtcct tcatgtaagc aaggaacttg aagatgctga tgccggcaat 997681 ttttgcgaca atcccgaaaa taacaattaa gaagaaagca agcgcgacat aaaccaatcc 997741 gacgagcttt ccgagagaga taagagaacc gagtccgaat ttagacacag tcactccgat 997801 aagagcgaaa acgccgaatg gcgccacttt catcacaagg tttacaacgt ggaacatggc 997861 atgggataca ccttcaaaaa aggctaatac aggcttgcct ctttcaccga tcgcggaaat 997921 acccaatgca aatagtactg taaagcagat gatggctaga agatcccctt cgaccaatga 997981 ctggaagaag tttgtcggca caatatggag gaacgtttcc gccactgatt tattactttg 998041 ttctttttca gtttcaacat attgactgat gtccgatttt tgagcttcgt gtatattaac 998101 tcctgtaccc ggatggaaga tgtttgcaag ggctagtccg agaataatgg caaaagtcgt 998161 gatgatctcg aagtacagaa tcgttctgaa gcctaattta ccgacttgct ttccatttcc 998221 tgcaccggct acaccgatga ttaagctgga gacaacaata ggaatcacta tcattttgat 998281 taagcgtaaa aagagatccc cgattggctg caggtaagta ggcaatgctg ggttgccata 998341 ccaaatgacg ccaacaatga cacctagaat aagtccaacg aatatttgtg tggctaatcc 998401 aaacttaatt cttttcatag attacctccc aaaaaacaaa gtatcaacat atatcatgaa 998461 tagacatata tttaatctca ctattagatc aaattataat agataagaaa tcaattcgtc 998521 tatagtaaat tatatttcga aaataaagaa tattcaatga cattatgata atcaccagaa 998581 ttatctaaaa acaggtgagc tttgacctaa cctgactatt atttcaaaat taagagatat 998641 gtgaaaaaat aagaaaatcc cacgcgtaag gcgcgggatt ttcgctcatt acaaatcgtt 998701 tacttttata cagtcattgc agatattacc ataacactca tgctgctctt ctatcttttt 998761 tccgcattcc gcacactttt tcgaaggcag gtttctaaaa aattctgtga ttttccccag 998821 cataaccaat ccctctttcc cctttgtagt gatttcattg taatataaca gattacaaaa 998881 atcaataact gttttgatac aatgtttaaa acatgctttt ttcaagaaaa atgggtatat 998941 tgaaggagga ccaatttttt tgaaaagata ggaggacatt atgaaagtta cagttatcgg 999001 atgctatggc ggttttccgg ccgcaaatga agcgacgtca ggctatttgt ttcagtcagg 999061 tgattactct ctgcttgttg attgcggcag tgccgtattg tctaagctgt tcggatatgt 999121 gccggcggaa aagctggatg cggtcgttct gtctcattat caccatgacc atatcgctga 999181 tatcggaccg ctgcaatttg ccaagcaagt cggttcgttt ctcggcaaag gagagcatac 999241 gcttccgatt tacggacatg atgctgatat agaacagttt caaaagctta catataaaac 999301 acatacaaaa gggatcgcct atcagccgga tcagccgctg actgccggtc cgtttacgat 999361 caccttttta aaaacgattc acccggtgac gtgctatgcc atgcggatta ctgacggcag 999421 ccacactgtc gtttatactg ctgattccag ctatcaggat tcatttatac cgttttcgaa 999481 agatgctgat ttattgatct cagaatgcaa tttttatgcc gatcaagacg gaacaagtgc 999541 aggccatatg aacagcctgg aagctgggcg cattgcaaaa gaagccggag cgggagaact 999601 gctgctgaca catttgccgc attttggcgt gcatgacaac cttcgcaaag aagcgaaaac 999661 cgtttttaac ggagaagtga atattgcgaa atcaggtttt gtgtgggaag gataaaggag 999721 gagcaccatg ttatttatag acaatcaaaa tatcaatgat ccgcggatca atcttgctat 999781 cgaggagtac tgtgtaaagc atttagaccc tgaacagcaa tatttgctct tttatgtgaa 999841 tcaaccgtct attatcattg ggaaaaacca aaatacaata gaagaaatca atacaaaata 999901 tgttgaggaa aacgggatta tcgtcgtccg ccgtttatca ggcgggggcg ctgtgtacca 999961 tgatctgggg aacttgaact tcagctttat taccaaggat gacggggaca gctttcataa 1000021 ctttaaaaaa ttcactgagc cagtgattca ggcgttacat cagcttgggg ttgaagccga 1000081 attaagcggc cggaacgaca ttgtagtaga tggccggaaa atatccggaa acgctcagtt 1000141 tgcaacgaaa ggccgtattt tcagccacgg caccctcatg tttgattcag ccattgatca 1000201 tgttgtatca gcattaaagg tgaaaaagga taaaattgaa tcaaaaggca tcaaatcgat 1000261 cagaagccga gtggcaaaca tcagtgagtt tctcgatgat aaaatgacca ccgaagaatt 1000321 ccgcagccat ttgcttcgcc atatttttaa cacaaacgac gttggaaacg tgccggagta 1000381 taagctgacg gaaaaagatt gggagaccat tcatcaaatt tcgaaagagc gctatcagaa 1000441 ttgggattgg aactacggcc gctcaccaaa atttaacctt aatcattcga agcgttatcc 1000501 ggttggatcg atcgatttgc acctggaagt caagaaaggc aaaatcgagg actgcaaaat 1000561 cttcggagat ttcttcggtg tcggtgatgt atctgaaatt gaaaacctgc tggtcggaaa 1000621 acaatacgaa cgcagcgtca tcgctgatgt gctcgaaggt gtgaatctca agcattactt 1000681 tgggaacatt acgaaagagg atttccttga tctgatttac taaggcaaaa cacatcgttt 1000741 gaaagagcgg ttgtgttttt gaaataatgg aggcaggagg gattcacatg aaagtgtttt 1000801 taatcggagc gaacggacaa atcgggcaaa gactcgtctc tttattccaa gataatcctg 1000861 atcattccat cagagcgatg gtcagaaaag aagaacagaa agcgtctctt gaagctgccg 1000921 gtgcagaagc tgtgcttgcg aatctggagg gcagcccgga agaaatcgcc gctgcggcaa 1000981 aaggttgtga cgcgatcatt ttcacagccg gttccggcgg cagcacaggc tatgataaaa 1001041 cgctgctggt ggatcttgat ggagcggcaa aagccattga agctgcggcc attgccggaa 1001101 tcaaacggtt tattatggtc agcgccctgc aagcccataa ccgtgaaaat tggaatgagg 1001161 cactcaagcc ttattatgtg gccaagcatt atgctgataa aattctggaa gcgagcggtt 1001221 taacctatac gattatccgt ccgggaggcc ttcgcaatga gcctggaacg ggaactgttt 1001281 cagcagcgaa ggatctggag cggggattta tttcccgtga tgacgttgca aaaacggtca 1001341 ttgcctcttt agatgagaag aatacggaaa atcgggcctt tgatctgaca gaaggagata 1001401 cgccgattgc cgaagcattg aagaaactat gacagtactg acactcaggg ctttttgctc 1001461 ttgagtgttt ttttctgttt ctctataatg gagaagaaag cttggcttca ataatgaatg 1001521 actattcatt cacttaaggg gtgggagaat gaatcttgtt tcaaaattgg aagaaacagc 1001581 atctgagaag cccgacagca tcgcatgcag gtttaaagat cacatgatga cgtatcaaga 1001641 gctgaatgaa tatattcagc gatttgcgga cggccttcag gaagccggta tggagaaagg 1001701 ggaccattta gctttgctgc ttggcaattc gcctgatttt atcatcgcgt tttttggcgc 1001761 tttaaaagct gggatcgtag ttgttcccat caatccgttg tacacgccga cagaaattgg 1001821 ttatatgctg acaaatggcg atgtaaaggc aatcgtgggc gttagccagc ttttgccgct 1001881 ttatgagagc atgcatgaat cgctgccaaa ggttgagctc gtcattttat gccagacggg 1001941 ggaggccgag ccggaagctg cggacccaga ggtcaggatg aaaatgacaa cgtttgcaaa 1002001 aatattgcgg ccgacatctg ccgctaaaca aaaccaagaa cctgtacctg atgataccgc 1002061 ggttatttta tatacgtcag gaacgactgg aaaaccgaaa ggcgcgatgc tgacacatca 1002121 gaatttgtac agcaatgcca acgatgtcgc aggctatttg ggaatggatg agagggacaa 1002181 tgtggtctgc gctcttccca tgtttcacgt gttttgttta accgtctgta tgaatgcacc 1002241 gctgatgagc ggcgcaactg tattgattga gcctcaattc agtccggcat ctgtttttaa 1002301 gcttgttaag cagcagcagg cgaccatttt tgccggtgtg cctacaatgt ataactactt 1002361 gtttcagcat gaaaacggaa agaaagatga tttttcttcg atccggctgt gcatttcggg 1002421 aggcgcgtcc atgccagtcg cgttgctgac ggcgtttgaa gaaaaattcg gtgttaccat 1002481 tttggaaggc tacgggctct cggaagcatc acccgtcacg tgctttaacc cgtttgacag 1002541 gggcagaaag ccgggctcca tcgggacaag tatcttacat gtcgaaaaca aggtcgtaga 1002601 tccgctcgga cgcgagctgc ccgctcacca ggtcggcgaa ttgatcgtga aaggccccaa 1002661 tgtgatgaag ggctattata aaatgccgat ggaaacagag catgcattaa aagacgggtg 1002721 gctttatacg ggggacttgg caagacggga tgaggacggc tatttttaca ttgttgaccg 1002781 gaaaaaagac atgatcattg taggaggata caatgtgtat ccgcgggagg tggaggaggt 1002841 gctgtacagc catccggacg tcaaggaggc ggttgtcatc ggcgtgccgg acccccaaag 1002901 cggggaagcg gtaaagggat atgtggtgcc gaaacgctct ggggtaacag aggaggacat 1002961 catgcagcac tgcgaaaagc atctggcaaa atacaagcgg cctgccgcca ttacgtttct 1003021 tgacgatatt ccgaaaaatg cgacggggaa aatgctcaga cgggcactga gagatatttt 1003081 gccccaataa aatgaaaaag cgaagcggtt agcttcgctt tttcattttc aatcctttgc 1003141 ttctttttta ataatattta gcagcgcctt tgtatcattt ttgcttaatt tgtagtatgt 1003201 gccatccttc aaaaaaacgg cttgctggct gccgtcaatc catagtctga atgagtcata 1003261 ccggtcttta tgaaacttga ttgtcccttc gtaatcaggg gctgatgttt tttctgtctt 1003321 cacctgtttt ccctgattca taatatccag catatctttg acgtgctgtc ttttttcaat 1003381 ctcgatatct tcctggccgc ttgaagacag tgtgatcaaa tccgcgtcta ccgattgata 1003441 cacatcgcct gatcggctgt aaagataaaa aaatgcgata aacacaagac cgattaccac 1003501 gatggctgcc actatttttt tcatttgcat cactccaaac attgttagtt ttcccagcga 1003561 tcggggtttc catgcttaaa agggtggaaa agtgcggaac acagcttggt tctaagaatt 1003621 tgaatttatg attacaatag aagtaacggg ttgatgtgag gagtgaggcg ttatgcgcaa 1003681 gtggattgcg gcagcaggac ttgcttacgt gctgtacggg ctgttttttt attggtattt 1003741 tttcctgtcg ggtgattccg caataccgga agccgtgaaa gggacgcagg ctgatccggc 1003801 ttctttcatg aagccgtctg agttggcagt ggccgagcag tattcgaatg tcaagaattt 1003861 tttatttttt atcggggtac cacttgattg gtttctgttt tttgttctgc ttgtcagcgg 1003921 tgtttcaaag aaaatcaaga aatggatcga agcggccgtg ccttttcggt ttttgcagac 1003981 cgttggtttt gtgtttgtgc tttcgctgat tacaacattg gtgacgctgc ctttagattg 1004041 gataggctat caagtatcgc ttgactataa catttccaca cagacaacgg ccagctgggc 1004101 taaggatcag gttatcagct tttggatcag ctttccaatc tttacgcttt gcgttctcgt 1004161 tttttattgg ctgatcaaaa ggcatgaaaa aaaatggtgg ttatacgcct ggctgttaac 1004221 agtgccgttt tcgctgtttc tgttttttat tcagccggtc attatcgatc ctttatacaa 1004281 tgatttttat ccgctgaaaa acaaagagct tgaaagcaaa attttagagc tggcagatga 1004341 agccaatatt ccggctgacc atgtatatga agtgaacatg tcagaaaaaa caaatgcgct 1004401 gaatgcctat gttacaggaa ttggggccaa taaacggatt gtattgtggg atacgacgct 1004461 gaacaaactt gacgattcag aaattctgtt tattatgggc cacgaaatgg gccattatgt 1004521 catgaagcac gtttacatcg gtctggctgg ctatttgctc gtgtcgctcg ccggatttta 1004581 tgtcattgat aagctttaca agcggacggt tcgcctaacc cgcagcatgt ttcatttaga 1004641 agggcggcat gatcttgcgg cacttccgct gttattgctt ttgttttctg ttttgagctt 1004701 tgcggttacg cctttttcta atgctgtctc gcgttatcag gagaataagg ctgaccagta 1004761 tgggatcgag ttgacagaga acagagaagc cgctgttaaa acgtttcagg atttggccgt 1004821 gacggggctg agccaggttg atcctccggt gcttgtgaag attttcagag gcagccatcc 1004881 gtcgatcatg gaacggattc aacatgcgga gaaagaagag aatgcgccgg aacatcagga 1004941 tgctgacaaa taaaaagaag caggtatgga ggaacctgct tctttttact attattgtgc 1005001 agctgcttgt acgttgatta acccttttcc atagtagaaa gagtttccaa gatatgttgc 1005061 agtgctttct aaacgatcac ggacttgcgc gtttgtccaa gtcgggtgct tagaaagaat 1005121 taacgctgct gctccggcaa cgtgaggagt cgccatggac gttccgttat aagcgccgta 1005181 agtgcctcca ggaagtgtgc tttggatgga cacgccagga gccatcacat caagctcaga 1005241 acctgcgctg gagaatgaag ctctttggtt gctgctgttt accgcaccta ctgcaatagt 1005301 agaaggatat tttgcagggt agccgactgt gcttgtgctt ccggatgaac cttcgtttcc 1005361 ggctgcggca gcaacgacga taccgctgga aacggctttg tcaacgactg ttttcagcgc 1005421 tgtagaacca gtaggtccgc caaggctcat gttgataaca tccatattgt tggaaatggc 1005481 ccactcaatg ccgttaataa tccagctata ttggccgctt cctgttgaat caagcacttt 1005541 tactgcatat aatgatgcgc ttggcgctac gcccagaaca ccgattgagt tattaagagc 1005601 ggcaatcgta ccggctacat gcgtaccgtg agaactgccg tcctggtatg ggtttgtttc 1005661 agaaggtacg aagcttgctc cgcctctgac gtttaagtca ggatgagaag agtcaattcc 1005721 gctgtcgata acagctactt ttacgttaga gcctgtgtag ccttgagagt gaagagccgg 1005781 cgctttaatt tgagaaatgc cataaggaac agattgcgca tattcatgtg caatatgatc 1005841 ttcttccaca tatgcaacgc tcggatcttt tttcaattct tttacagctt tttcatccaa 1005901 tgttgctgcg gccgcgttaa catacttaaa ttgcttttga acctttccgc ctttttcaga 1005961 aataacatcc tttttcttgg cggaactcat ggcactcatt gtctgtttaa atccgacaat 1006021 gtatttcttt tctgtactgc tttttccggc agcctgcgca gacatgttgc tgaacgccat 1006081 cgtaaagatt aacgttaacg caaacaacaa gctgatccac aattttttgc ttctcactct 1006141 ttaccctctc cttttaaaaa aattcagagt agacttactt aaaagactat tctgtgaatt 1006201 tattgtaata gatggaataa tattttagta gacccatttt tttgagatga ttttatctct 1006261 atttaggtat atcatctctc gctatttccg tagagactcg aaataactat tttcatacag 1006321 aaaagaacga aaatagacat gagtaaatgt tcattatgct gaaatgtcat gcttttttag 1006381 gttaaatgct cctgagtccc ggcaaattcc tgtcgaaaaa attcgttcaa atgacctgcg 1006441 tgtgcttccg tgagaacaat ggatattatc gtgatatttt ttcaaagcat gatgataaaa 1006501 gtattctgaa aaataaactt tacagaaaag ggatagaatg aaaaaattat tgagagggag 1006561 gaagaaataa gatgaacatt cgccaagcaa agacatcaga tgcggccgcc attgcgccgc 1006621 tgtttaacca atatcgggaa ttttatagac aggcatccga tttgcaaggg gcagaggctt 1006681 ttttgaaagc tcgtttggaa aatcacgagt ctgttatttt gatagcagaa gaaaatggag 1006741 aattcatagg ctttacccag ctctatccaa cgttttcttc tgtgtcaatg aaaaggatat 1006801 acatattaaa tgacttattt gtcgttcctc atgcgcgtac aaagggagcc ggcggccggc 1006861 tgctttctgc cgcaaaggat tatgcagggc aaaacggggc aaaatgttta acacttcaga 1006921 ctgagcacca caaccggaag gcaagaagct tgtatgagca aaacggctat gaagaggata 1006981 ccggatttgt ccattattgt ctcaatgtgc cggcgaagtg aaaatggcgg cttgatgatt 1007041 tggttttttg aacgttcttc ggttacgata taaatgaaaa ggagtgtgcc gaatgtcaac 1007101 gttatttcaa gccttgcagg cagaaaaaaa tgccgatgat gtttcagtcc atgtgaaaac 1007161 catatcaaca gaggatttgc cgaaggatgg tgtcctgatt aaagttgctt attccggcat 1007221 taattacaaa gatggtctgg ccggaaaagc aggaggcaat atcgtcagag agtatccgct 1007281 tattttaggc attgatgctg cgggtacggt cgtctcttcc aatgatccgc gttttgcgga 1007341 gggggatgag gtgatcgcga caagctatga gctcggtgtc tcacgtgatg gcggattaag 1007401 tgaatacgct tcggtgcctg gtgactggct ggtgcctttg ccacagaatc tttcgttaaa 1007461 agaagcgatg gtgtacggaa cggcgggatt tactgcggcg ttatcagtgc atcggcttga 1007521 acagaacggt ctgtctccgg aaaaaggcag cgtgctagtc acaggagcaa ccggcggtgt 1007581 cggcggaatt gcggtatcga tgctgaacaa gcggggttat gatgtggtgg caagtaccgg 1007641 aaaccgggag gcggctgatt atttgaaaca gcttggtgca agcgaagtaa tcagcaggga 1007701 agatgtctat gacggaacgc ttaaggcgct gtccaagcag caatggcagg gagcggttga 1007761 tccagtcggc ggaaaacagc ttgcctcgct tttaagcaaa attcaatacg gcggatctgt 1007821 cgcagtgagc ggcttaaccg gcggaggaga agttccggca accgtgtatc cttttattct 1007881 tcgcggagta agcctgctcg gaatcgattc agtatattgt ccgatggacg tcagagccgc 1007941 tgtttgggag cgcatgtctt ctgatctcaa gcctgatcag ctgctgacca tcgtggacag 1008001 ggaagtatca ttggaagaaa cgccgggtgc gttaaaagat attttgcaaa atcgcattca 1008061 aggaagagtg attgtgaagc tttaacagga tcagcttgca gagaatgtta tttttctgca 1008121 agcttttttg tggacaggat gatcagctgc tgaactgctg tgtcgcgaaa caagattttc 1008181 ctgtaagccg aactttctct tctcatttta aaaataattg gtgataatga ttctcattcc 1008241 gtgttatact actcttggac atcttaacca tagaaactac caacaggaga gactggaaca 1008301 tatgaaaaaa acactgatta ttcttacagt tttacttctt tctgtcttaa cggctgcttg 1008361 ctcgtcttca agcggcaatc aaaacagtaa agaacataaa gtggcggtaa cacatgattt 1008421 agggaagaca aatgtgcctg agcatccgaa gcgggttgtt gttcttgagc taggttttat 1008481 tgatacactg cttgatctcg gcattacgcc tgtcggggtt gccgatgaca acaaagcgaa 1008541 gcagctgatc aacaaggatg tgctgaagaa aattgacggc tacacatctg tcggcactcg 1008601 ctcacagcca agcatggaaa aaatcgcttc attaaaaccc gatttaatta ttgctgacac 1008661 gacccggcat aagaaggtgt acgatcagct gaaaaaaata gcgccgacga ttgcacttaa 1008721 taatttaaat gctgattatc aggatacaat tgacgcttcg cttacgattg caaaagcagt 1008781 cggcaaggag aaggaaatgg agaaaaagct gacggcgcat gaagaaaagc ttagcgagac 1008841 aaagcagaaa atcagcgcga acagccagtc cgtgcttttg atcggaaata caaatgatac 1008901 cattatggcc agggatgaaa acttctttac atcgagactt ttaacacagg tcggctaccg 1008961 atatgcaatc agtacgtcag gcaatagcga ttcaagcaat ggcggcgact ctgtgaatat 1009021 gaaaatgaca ctggagcagc tgctgaaaac agatccggat gtgatcatcc tgatgacagg 1009081 aaaaacagat gacctcgacg ccgacggtaa acgcccgatc gaaaagaatg tcctttggaa 1009141 aaaactgaag gcagtgaaaa acgggcatgt ataccacgtg gatcgtgcgg tgtggtctct 1009201 gcgccgcagt gtagacgggg cgaatgccat tttggacgag cttcaaaaag agatgccggc 1009261 tgctaagaaa taaaagaaaa gacaggcaaa cgcctgtctt tttcttattt gataaagccg 1009321 gataagtggc tgttgatatt atagtctttt atccgccatt tttcttctgc aaattcaatg 1009381 ttgctgaggc aggcgttgac gagacgggtg ctttgaagct ccgggtcacc gccggatatt 1009441 tctgtcagca gggcgtgaat tgccgcaccg tgcgccacga tcagcacctt cttgtttgga 1009501 tacgcctgat tcacttttgc caaaccgccc atcagcctgt cagtgagttc ttctaaggtt 1009561 tccatattcg gatagatgtt atctggatag cgctttgtcc gttcctccag cggcatgccc 1009621 tccgcgtcgc cgtaatcgcg ttccttaaaa tcatccatct cgactatcgg aagatgcaga 1009681 tattcattaa taatttccgc ggttcttttc gctcttttca gcgggctcgt cacaataata 1009741 tcccaagaaa agtcctttac atattctccg gtttctcttg cttggcgttc acctgttgcg 1009801 tttagcggga tatcggtttt gccttggcat ttttgctgca ggttccaatc ggtttctcca 1009861 tgtcttacta aacaaacggc tgtcataaaa tccccttcct gactttattc atatcgctat 1009921 tatactaaat cgaaagcgtg tgtcctatga aaaagcctat gcaagaactt caaataataa 1009981 agccagtccg attccgccgc cgcttccgat ggctgcaaca gcatattgac agtctggccg 1010041 tcttttcgct tcataaaaca atctggttac cagagctgca cctgatgcac cgtacggatg 1010101 gccaagagct aaggcgccgc cgcgcacatt gatttttgaa aagggaatgc cgagttcttg 1010161 cgagcagaca caaattttga cggcaaaggc ttcattgatt tcaaataaat cgatatcatc 1010221 aggtgttaca tcgtgtgtat gtaagagctg acgaatcgcg acaaccggtg ccgcgggcgg 1010281 aaagttgggg tgaatgccgc tgacagcgct gccgataaac cgaagcacag gcttaagtcc 1010341 cagggctgct gctttttctt cttccattac caaaagagcg gctgctccgt ctgctatgcc 1010401 actgctgttg gctgctgtga ctgttccgga gctggtgtcg aaaaccggct ttgcacgggg 1010461 aataatcgct tctattggcc gcgttttcaa aaatgcttcg tccgtctcca attccccgag 1010521 agcaacaact tcttcacggt aaaatccttc atcatgcgcg ttcctgctgc gttgatggct 1010581 gagaagcgcg tactcatcct gcatgcttct gctgatggaa tagcgtgcag ccgtatattc 1010641 tgccgcaatg cccatgtctg gatcgccgat cgcatctgga gaaaagcgag cccgttctga 1010701 aaaaggggat tggctgctgc tttctgagcc gcccgcgata tacatcgtgc cggctcccgc 1010761 ttgaataagg ctgcaggcat agcgcacagc ttcaaggccg gagccgcact gtctgtcaat 1010821 tgtcattccg ggaaccgata aaggcagtcc ggcttgaagg gctgacagtc tggccaggtt 1010881 gccgcctctg ccagtagcgt ttccgagaat gacctcgtca acttgatcct ctagctttcg 1010941 gctgagacag cggatgatgg gagccgccaa atcctccggc aggaagggct tcagcagtcc 1011001 gttttgattt ccaaagatcg ttcgttttgc atcaacaata accgcattca tttatactgt 1011061 acactctctt ccagccattt tttcactctg gaacgggcaa tttttccgct gctcgtttcc 1011121 ggcaagctgt ctgcaaacac ccattttttc ggaattttat aggaggctaa tttctgttta 1011181 caccaggctt tcagtgttct ggcattagcg tttccaagaa tgacagctac agcgatttct 1011241 ccccaatact cgtcgggaat gccaacgaca gccgcgcttt caacctctgg gcaggcgaga 1011301 agcacacgtt caatttcttc tgggaaaata tttaatcctc cgtacacgat catcccgttt 1011361 tctcttcctg atatgtatag aaagccctct tcatcaacgt agcccatatc atctactgtc 1011421 atccattcat ctggtgtgct gccgttcaca tagccggaaa acctcatcgg gcttttgaca 1011481 aatatttttc cgatttctcc tggctggcag cgttctcctc cagcgttgcg gatttcgatc 1011541 cggacattat gaaaagggcg gcccgctgaa tgcggcttcc gtttgctgtc ttccggtgaa 1011601 gaaaacgtca caaaactaag ctctgatgtg ccgtaaaaat cgtacagctt gagatgaggc 1011661 catgcagcgg caagcttctt cttggattct gccggccagt ctgcgccgga tgaaatgatt 1011721 ttgacgggac tgtcgggaaa accctcaatc cttgcgaggg cgtctgtcat cgtcggtacg 1011781 gtatagagaa cactgatgga ttcacggcac agccattcct tcgctttggc aggagaaaac 1011841 tttttcagca aacaaacggt tcctccgaga aacaaagtgc tgacagcccc atataggaag 1011901 tgagaggaca ttaacgctcc gggaatcaga accttatcat ctgatgaaat cgaaaaatct 1011961 gtttctgtac aggtaaagct ctccatccat gagcggtgag atcgcgtaaa ggccttcggt 1012021 tttcctgtcg agcccgacgt aaatcccata taaaaagggt gctccggatc aatggtaggc 1012081 aagggatcag cggctgcctc agaaatatct gccatacagt tatccagcaa tacaacaggt 1012141 gtctggctat ctgtcagttt gtttttgaaa aaggctaaag taaccacaag atccgcattg 1012201 cttatggaca gccgctcctt acattcagcc gggctccagc gtgtgtcgat gggaatggcc 1012261 gtacatccag ccgctgcggc tccggcaaac agctgtaaaa acgcgagact atttgggagc 1012321 aggatcgcca cacgattcgg catgctcggc tgtgaccgca gccaatttgc ggtttgagag 1012381 acaagccgat cccaatcatg gtacgtgatt tgctccgatt cagtctggat cgctacacgg 1012441 ccgggcgatg tttcggcagt agatgaatag gtatgagtaa ttgtcatgta ttgtcatcct 1012501 ccttttgtaa acatcgtatc agaaagagac aaggcttgag tgatttttat cgccagaaat 1012561 gcagatacag ccgcttttat caaatcacca ggcacatatg caaggctcat gaaggcggcc 1012621 tgtgacaaat caatatgcat gataaaagct tgtaccggta taccaagcag ataaataaag 1012681 atgatgccga atacgatatg agtgaaaaag agacgcaata ctgtcacctt ccgcagcctg 1012741 ttagcggcta aactgatcag ccatgaagcg aggggataag caatcaaaaa gcctgcgctc 1012801 ggtccgaaaa acacaccaaa accgcctcgt ccgccgggca acagcggcgc tccgaaggcg 1012861 acgagcagca aaaagacaag ctggcttaag aaagcagact ttggcctgag aatgctgcct 1012921 gccaacatga caccaagcgt ttgcaatgta atcggaacgg gtgtaaagga taagaagaga 1012981 gggggcataa agccgagcac tgccatcagc gcggtgaaaa tcgcaatatg catcatgtcg 1013041 attaatttca gcatgtgaaa tcctccaaaa agtaatcaaa tatggttata caataaatgc 1013101 aggtaattat tatgtcaact gatttttaat ttaagtttac ataatgaacg caaaaaaacc 1013161 ggccgtatgg cagaccggtt tttgatggtt attcttctgt caggatgaca agcgaatcaa 1013221 cggaagcggc cacatgggaa acggcgcggc tgacttcctg aagccctcca agaaaggctt 1013281 gcagatcgac gtcgattttg cctgattgct ctttgctgat tttcatgctg tggacgattt 1013341 catcgaataa gcggttaatt tgcgtcattt tttctttact ttcgctgact agctcattca 1013401 cgtctttgat atgcttggat acaatgttga tttgtgtatt cgtattgttc acaagctcag 1013461 aaacagtaga gacggttttt ttcgtatcct cagaaagctt ccgcacttca tttgccacga 1013521 cagcaaagcc tttgccgtgt tctccggcgc gggcggattc aatagatgca ttgagcgaga 1013581 gaaggtttgt ttgttcagct atgcctgtga cgatgccgaa gattttttca atttgctgcg 1013641 cgatttcatc cagcttgacc atttcttttt cgatttggac aaggcttgtg tcaattttgt 1013701 tcatctgttt ttgctggact tctagctctt tttttccgcc gatcgacttt tcttcaacag 1013761 tgctggatgt tacagtgccg gctttggatg cttgagaaat gccttcagat ttgtccacaa 1013821 gctcttgaac tgatctgctt gtttctgaaa acagattggc aatcgatcca gaggtttctt 1013881 gaattttctg atgaagaagg tttttctttt cttcttgttc atcacgggtc tggttgtact 1013941 cgctttgaaa cgcttcaagg acaagctgct gttctaagtt caagattttt gttgttgctt 1014001 taatggcttt tagcagttct tgctgatttg taatggacgc ttcataaatg tcaatcattg 1014061 acaaaaggag ctcttgaaac gcacccatat accattttgg caaaaggccg attcttaaat 1014121 ggatggaggc gattcggtta cgcttttcaa taaattcatc atcgataacg cctgcaaaca 1014181 tttcctgaat atgccgtttt aacgtttgtt ttaagcggtc aactgagctg tgatcattaa 1014241 tgatatccat caatgagctt tcatggtcaa ggtttttata aaacgcatcg acgatattta 1014301 cgatattttc ttgaatgagt ggctgaagct gctctaacac ataaagctca gcatctccca 1014361 acctgaccat tttgagctgt tttttgacat ctgcatgttt gtttgtgagc tgaatgcggt 1014421 ttttttgttg tccgtttgaa tctgaaaagt aagctgtttc ttgttttctg tcttttttaa 1014481 ataacaatac aatgatcccc cttgggaaaa atataatttt tactttttgg ctttttaagc 1014541 ctttttcttt tttatcggcc aagggaaaca tgaatgaagc tgcagatgaa aaatatttga 1014601 aaaaacgttc attaaaatga acggtttaat cgagatctat ttgttttaat ggtttaatgg 1014661 ccggaccctc tacaacttcg ccagatggct taaagcgtga tccgtggcac ggacaatccc 1014721 acgtatgctc actgtcgttc cactcgacct cgcagcctaa atgggtacaa gtcgtatcaa 1014781 cgagatggag gcagcctgtc tcatcacgaa atgctcccgc tcgcctgccg tttatggtga 1014841 cggctttccc ttctcctggc gaaatgtctt caaattggac atcaggcttt tcaagctttc 1014901 cttttatcaa atgcttggcg acatctgcat tgtaggaaat cactttctgc aacccgggat 1014961 tcagatggaa acgggacggc gtgaaaatgc tttcgtatgg gttttctttt ttctccacaa 1015021 ggtctgacaa taaagtggct gcgactgctg aggacgtcat gccccatttt ttgaacccgg 1015081 tcgctactag aatattgtcc tcattttccg acatcggccc gataaacggg attttgtcga 1015141 tcgtcactag atcttgggtg gaccaataat atggaatgct ttcgatgccg atggtgcttt 1015201 cggccagttg tctcagtgtt tcataatgtg tagacatggc ttttccctgg cctgttttat 1015261 ggcttactcc gctgaagaga atcagctttt caccgtttac aaccgtatag cggagcgcca 1015321 ctgacggctg atcgatactc aaatacatgc cctcgggata ctcgatcttc ggcttgatgg 1015381 caaggacata agatctgtcg gagtacattc tcgcagcata taatccgcct ccgtcataaa 1015441 aagggaagtg ggaacagcat atgataaagc ggctcttaat ggcgtgccgg ctttttgtta 1015501 ccacttcggg cctttcgcct tttttgatat caagcgcaac ggtctcttca taaattcggc 1015561 cgcctttttg aacaatttgc tccagaagcg cttttaagta ttgaagcgga tgaaattgag 1015621 cttgattctt catgacaagc gccagcttag aacctaaggg aattggaaga tccttgataa 1015681 ggtctctttc aattccgagc tttgtgtatg cctcatgctc ggtgtggatt ttttgaacag 1015741 cgttttcatt tgccgtataa agatatgcgt cttgctcgat ccattcacaa tcaatttgat 1015801 gttcatccac aatgcctttt atgtaatcaa ttgcgttttg gtttgcttca taataaagcc 1015861 tcgcatggtt taatccgaaa tggcggataa attcgtcgta tatcatgtca tgctgtgcgg 1015921 taactttagc agttgtatgc gcagtggttc cgttaagaac ctgatttgct tcaatcaaaa 1015981 cgacacggaa gcctctcttc gtaagttcat atgccgttgt gattcccgta atcccgcctc 1016041 cgataatggt gacgtcacat tcagtgtcct cttgaagcgc aggaaaagaa ggcaggtcag 1016101 ttgatgtttt ccagtatgtt tcaggtgctt cctttgcaaa atgttgatta gccaagccgt 1016161 tatacctcca atcagattta ttcttaattt ttccatattc tatcttttca tacataggaa 1016221 gcaggcattg ttcataacat aataaggttg aaaaggagtg atttcattgg cgaatcaaaa 1016281 aaagaaaaca ttaccgcctc agcaccagaa ccagcagcct ggttttgaat atctgatgga 1016341 cccgcgtccg gtttttgata agccgaagaa agcgaaaaaa ttagagggca aaaccgctat 1016401 tattactgga ggagacagcg ggattggacg cgctgtctcg gtgttattcg caaaagaagg 1016461 ggctaatgtg gtcattgtgt atttgaatga acatcaggac gccgaggaaa caaagcagta 1016521 tgtagaaaag gaaggggtaa aatgcctgct gattgcagga gatgtcgggg atgaagcgtt 1016581 ttgcaatgat gtggtcgggc aggcaagcca agtgtttcca tccattgata tattggttaa 1016641 caatgcagct gagcagcatg tccagcccag cattgaaaaa atcaccagcc accagctgat 1016701 cagaaccttc caaacaaaca ttttttccat gttttactta acaaaggcag tgctgcctca 1016761 tttaaaaaaa gggagctcta ttattaatac cgcttcaatt accgcctata aaggcaataa 1016821 aacgctgatc gattattcag cgacaaaagg cgcgatcgtt acgtttacaa ggtccctttc 1016881 ccagtcgctt gttcagcagg gcatacgggt caatgcagtg gcaccgggtc ccatttggac 1016941 accgcttatc ccggccagct ttgccgcaaa agacgtggaa gtgtttggtt cagacgtgcc 1017001 gatggaacgc ccggggcagc cggtcgaagt ggcgccaagc tatctatacc ttgccagcga 1017061 cgattccaca tacgtcacag ggcagacgat tcacgtcaat ggcggaacaa ttgtgaacgg 1017121 ataataaaaa gccaatcctt gaaggattgg cttattcgct ctgcttgagc gctgcatatt 1017181 ctttagagag cgtaagaaac gcatctttat ctttttcgtc caaggctttg ttaatttggt 1017241 ccgtcagcat ggcaagccga cggttataca aggattcatc gagcaccatt tgaatgtaaa 1017301 tatccgtcat tgtgacatcg aattcttttg ttttttgcgt gttgcgggac ttcatgagct 1017361 cagtgtacga ttttttctct ttcataaaga atccccccaa tgcctttttt atagtatatg 1017421 gataacggtc gaaaaaatca ataaattttt ataattttta gacaactaat acttggcaat 1017481 ctatcgacat atcctgcaaa atgccgtaaa ccggcaagtc ttatgaaagt aaaatcggtt 1017541 tattactagt catttagtac cattaaatat cattaaaaga tgattttatc ttaaatgtta 1017601 aaaaaacctg tcgttttaca aaaacagatg atagattatt agtataaatt ttgcagaaaa 1017661 aggatggagg ccataatatg agtcagaaaa cagacgcacc tttagaatcg tatgaagtga 1017721 acggcgcaac aattgccgtg ctgccagaag aaatagacgg caaaatctgt tccaaaatta 1017781 ttgaaaaaga ttgcgtgttt tatgtaaaca tgaagccgct gcaaattgtc gacagaagct 1017841 gccgattttt tggatcaagc tatgcgggaa gaaaagcagg aacttatgaa gtgacaaaaa 1017901 tttcacacaa gccgccgatc atggtggacc cttcgaacca aatcttttta ttccctacac 1017961 tttcttcgac aagaccccaa tgcggctgga tttcccatgt gcatgtaaaa gaattcaaag 1018021 cgactgaatt cgacgatacg gaagtgacgt tttccaatgg gaaaacgatg gagctgccga 1018081 tctcttataa ttcgttcgag aaccaggtat accgaacagc gtggctcaga accaaattcc 1018141 aagacagaat cgaccaccgc gtgccgaaaa gacaggaatt tatgctgtac ccgaaagaag 1018201 agcggacgaa gatgatttat gattttattt tgcgtgagct cggggaacgg tattagaaaa 1018261 ataggaagga gctgaccgaa cagggcagct cctttcataa agctatgccg tcggaattcc 1018321 tccggtgatg ccatatacct gagatgtcac atagcttgaa ttctctgaag ctagaaatac 1018381 ataaacatcg gccaattcca ctggctgccc agcgcgattt aatggagctg gcggcgtgcc 1018441 ttgtccgaat ttcgggatgt tttccgtcgg ctgtccgccg gaaatttgca gcggtgtcca 1018501 aattggtccg ggcgcaactg aatttactct gatgcctttg gaagcaagct gttttcccag 1018561 tccgacggta aagccgataa tggcgttttt cgttgctgcg taatctaaca gcatcgggct 1018621 tggattatag ccttcaactg aggtagttgt gataattgaa gctccctccg gcaaatacgg 1018681 aagcgccgct tttacaaccc agtaaaggga aaagacgttc acttcaaatg ttttatagat 1018741 ttgttcagta ggcagatctt cgatgttttc gaccgcttgc tgtttgcctg caacgagcgc 1018801 tagcacatca agtccgccga gttcgtgatg cgactgtttg actagatctt ggcaaaagga 1018861 ttcgtcgctc aagtctccgg ggatcagcac tgcttttcgg ccttctgctt caatcagctc 1018921 ttttacctct tcagcatctg gctgttcctc gggcaagtag ttaatagcca catcggcacc 1018981 ttctctggcg taagcaattg cggcagcgcg gccgataccg gaatcgccgc ccgtgacaag 1019041 cgcttttcga cccgttagtt tacctgatcc tttgtagctt ttttctccgc aatcagggac 1019101 aggcttcatg ttcttttgca ggcctggcgg ttcttgatat tgttcgggaa attcatcatg 1019161 aaaaaatgct tttataggat tcgtaagatt tgaatcagac atcagcaacg ctccttttct 1019221 gtttggtgta cattcgtatg tgtacccctg agcataagca gaaaaacatg ttttggcagt 1019281 ttgaatagtg aaggaaaaag aaaacaagaa aaaacaaagc cttcttccat atttatcttg 1019341 tcaaataaga ctatatgaat tatgataaat tcgagctata aatcaactaa atattgggtg 1019401 ttgggagagt gaatcgtcat gaaaaaagcg gcggcggttt tgctgtcact cggtctcgtt 1019461 ttcggttttt catacggagc tggccatgtg gcggaagcca aaacaaaggt gaaggtctat 1019521 aagaactgca aggagctaaa caaagtatac aaaggcggag tggcccgcac atcgaaggtg 1019581 aaaaacaaag gcggaaaaac gaagtacaag ccttacgttt ctaaggcact ttacgatgcc 1019641 aataaaaaca aagaccgcga taaagatctt atcgcctgtg aacggtaaat aagaaaaagc 1019701 aatctggtgt ccagattgct ttttttatgc ttaggccgcc tgatcggccg cagcgctttt 1019761 cgccttcctt gtcataaggc tgactgccat catgaccgtg atattcaaaa gcagggcgac 1019821 gatgccgaca ttcaagtctt ttgcggcttg cggcagagcc ggaaataaag tgccgatcgt 1019881 cgtttccgtc attgtaatat aagtaactgc tccgacacct gcaataatgc cggcgaaagc 1019941 tccttgcttt gtcaccatat tatgcttgag caggctgaac aaaagggcgg ggaatagctg 1020001 tgtgacaagg ctgtagccca tcaaaagcag cgtaacgatg gtattcccgc ctttgaaggt 1020061 aaaatacacc gaaatcagcg caatcaccgg cactaaaaac ttagcaagcg ccgatacttg 1020121 ctgttctgtc gtgcggggcg cgattacctt gtacacattt tttgcaaaca gtgtggaggc 1020181 ggacattaag atcatagacc ctggcacaag tgctgtcagc agtccggcag caccgataat 1020241 tccgacaaac caagggtcaa atgcttgcag agacagtctc aaaagcgaca aatccccgtc 1020301 tgcgccattc agatctggaa cttgcaggat agccgcaaag ccgacgaaaa ggacgaagag 1020361 caggaccagc tggtacaaag gcatgatgat ggcgttttta cgaaacactt ttgggttttc 1020421 ggctgaatac gaagcggaaa acgtgtgagg ccacatgtaa aaaccaagcg ctgtcaagag 1020481 tacggttgaa ctgaaccagg ccacactttg tcccgattcg gggagcgtaa gaaagccagg 1020541 ctttgccgtt tcaatctgct gaaacatgtc ttgaaatccg ccgtagtaat gaattggcaa 1020601 atacacacct aaaaacagaa cgacaaccag aatcatgatg tccttcacaa ccgatatcca 1020661 ggcagacccg tgaatgcctg aaaccataac ataaaccgtg atggaaacag cgccgatcca 1020721 gatggcagcg gtcggggtga ttttgccgta cgaggtttcc gatacaatca gcccgaggcc 1020781 tttcagctgc agtacaagat agggaatgag tgcggcgatg ccgaccagtg aaacgagaat 1020841 gccaagcagc ggactgttgt atttttttgt gaaaaaatca gactgcgaca tcagtttatg 1020901 ctgtttcgcg tacgtccaaa ctgctggaag aagccagtaa gaaaggatgt aggccagaca 1020961 tccgtaggcg atgatataaa aggctggacc gccttttccg taggcccagc cgctgccgcc 1021021 gagaaacgta aaagtagtat aaatttcgcc tgccatcaaa aggaagacga aaacagttcc 1021081 gaagccgcgc cctccgaccg tccactgctc caggttcatg tcttttcctt tttgggcgcg 1021141 tataccgaga aaaatactca agagcaggac accgaagatg atgatgagag ctgcattcat 1021201 tctgcttcct cctttttatt ttccttgtcg aggacataca caatcgccat cagcgcagag 1021261 gtcaaaagag cccacatcac aatataggca agaataaacg gcatgccgaa cacatagggg 1021321 gtcaccttat ttgcaaaagg gatgccgagt aagattccga taaagggtaa agcggcaaga 1021381 acgtgaatca gtttcataga atcctccttc tatttaggat tgaggtgtac aagcctaagc 1021441 gtactgaaaa tgatgtcgca gatatcgcag cacatgtcat tttttggagt gaaaggctgt 1021501 ggttcgaatt ataaataaat ttattttgtt tgtatagtgt gaattgtctg aaattaatgc 1021561 tctgaatcgc ccgaagaggg aacgggcagt atgattcaaa aggctcagag tctgtctggg 1021621 gcaaatagat agtatgttaa taattcgctg acctgctcac ggattcgcgg attaaaatag 1021681 cgatggtttt cttcataacc gtcgatgaca aatgtataga gtgtaaaggc ctcatcgcgt 1021741 tccgtctcgc ggattgcaat ttttcttttc ctcagttctt ttctgacctc catcaaatcc 1021801 ttttgtgcta tttttaatga ttcgctgata agctgtttat aaggatgctt caattttaat 1021861 gtgctttctt caattccggc gagatcacgg ttaaaaatcg taatggccat gggcaaaaag 1021921 agagcccgtt caattaaatc gtatatttcc tcctgcagat ttggcatatt gactccttct 1021981 ttctaaggga acgtttgttc tatttgtatt ctatatcggc tggtgaaatg tttcaagaca 1022041 gaaaaaatca ccaaaacttt ttagttttct gctgataatg tgtagaataa ggatagacaa 1022101 acccggtaag gagtataaat gttggagcat tttttatcct atttgacaca agaacattta 1022161 actgaattat ttcaaagcta tagggctttc ggtccgctca ttgctgtgct gctgccttta 1022221 attgaagcat ttctcccgtt tttgccgctg atcgtgtttg tggtggcgaa tacgaactcg 1022281 tttggcttgt gggaaggatt catcctatcc tgggcgggat caactgctgg ttccattctc 1022341 gtctttttga ttgtccgtca atacggacag agaaaattgc ttggatttat ccgcagtcat 1022401 ccgtctgtca gaaagctgat gttatgggtg gaaagacacg gcttcggtcc catgtttctt 1022461 ctgctttgtt ttccatttac accgtcagcc gcggtgaatg ttgttgccgg tttgtcaagg 1022521 atcggaacgc ggccgtttat tttggcggca gcctcgggga agcttgtcat gatttttatg 1022581 atcagcttca tcggatatga tctgcacgcg ctgattacac agccgattcg aacggtcatc 1022641 gccgtattgg tgatcactgt cttatggtat gtcggcaaaa aggtggagcg gtatctgcat 1022701 gtaagagcca gtcagcgtga gcatgatgga gggagacagt aacatgaaaa aacggttttg 1022761 gtttcttgcc ggtgtagtgt ccgttgttct cgccattcag gttaaaaatg ctgtctttat 1022821 tgattacaag gtagaaggcg tcagtatgaa cccgaccttc caggaaggaa acgaattgtt 1022881 ggtcaataaa ttttcgcatc gatttaaaac catccatcgt tttgacatcg tcctttttaa 1022941 aggccctgat cataaagtgc tgattaaacg ggtaatcggc ttgcccggtg aaacgatcaa 1023001 atataaagat gatcagctgt atgtgaacgg aaagcaggtt gctgagccat ttttgaagca 1023061 tttgaaatct gtttctgccg gcagccatgt aacgggtgat ttttctttga aagatgtgac 1023121 gggaacaagc aaggtgccga aaggaaaata ttttgtcgtt ggagataatc gcatatacag 1023181 cttcgacagc cggcattttg gtccgataag agaaaaaaat attgtcggtg tgatttctga 1023241 tgccgaataa aaagacgcta attgaagagg cgtctttttg tatgccgttt ggaaaaatgt 1023301 gttgaagaaa aatttgtaag gagctataat caaaattgtt acctgtgtaa caaaatttat 1023361 atattttttt gactggaggg ccgtttttat tggtttttgt tcgtttttca tgaaacaaaa 1023421 ggagtggtga atgatgatga aatatgaagc agtgattata ggaggagggc cggttggatt 1023481 tatgctggct tctgagcttg caatagccgg agtgggaaca tgtgtgattg aacggcttga 1023541 aaaacctgtt ccgcattcca aggcgttgac gctgcacccc cgaacgctgg agcttcttga 1023601 gatgagaggg attttagagc ggttcgtatc caagggaagc aagataccta ccggacattt 1023661 ttcaatgctg gatacccgtc tggatttttc aggcttggat acgagctgtc cttacacgct 1023721 tttgctcccg cagtccaaaa cagaaaagct tcttgaagat catgcacgaa gcctgggaac 1023781 agaggtgttt cggggtgccg aggcgctggc ggttacgcaa aacggggaag cggtccaaac 1023841 aatttttaag gatcgggacg gcagtgtacg gacgatcaca agcaagtttg ccgttggggc 1023901 agatggcgcc gggagtaccg tccggaaaca ggcgaaaatt gagtttccgg gaacagacag 1023961 cactgtcacc gctgcgcttg gggatgtggt gctcctttct ccgccgccgt caggtgtgct 1024021 gtccctttgc acaaaagagg gcggtgttat gattgttccg ttatctccag accgataccg 1024081 tgtcgttgtg atcagccctt atcgcacaca aacgccgaaa gatgtgcctg tgactgagga 1024141 agagctgaaa gctgacctcc tgcgaatttg cggaactgac ttcggtttaa ccgacccttc 1024201 gtggatgtcg cggtttggga acgccgcgcg ccaagcgaaa cggtatcggg acggcagaat 1024261 ctttcttgcg ggtgatgccg cgcatattca ttttccggcg ggcgggcaag gactgaatgt 1024321 cggccttcag gatgcaatga acctcgggtg gaaactggcg gcggccatca aaggctctgc 1024381 gccttcttgg cttttggaca gctaccatga tgagcggcat ccggcagcgg aagggctcct 1024441 cagaaacacg gaggcacaga caaagctgat cgatttcact caagcaggcc tccatttgcg 1024501 aagcatgatg tcggagctgc tggccttccc tgatgtgaat cgatatgtag cggggcaaat 1024561 ttctgcgctc gatgtcagat atgaagctga tcgtaccatg ccgccgaatc gtttgaacgg 1024621 ggcaaggctc cctgacatga agctgattct ttccgacggc aattcggaac ggctgtacag 1024681 ctttctccaa aacgggacat tcgttttgct gtcattgagg caggaagctg atgatcatat 1024741 cgaagtaaaa ggcttacgta cggtaaccgc ctcgcttgca gaaccgaatg aaaagttgcg 1024801 gaatgtgcat accatattga ttcgtcccga tggacatgta gcctgggcgg tggatgcatc 1024861 agcgcccgat tgttccgagg tgattcaaaa agggatcagc cgctggtttt ccgtcaccag 1024921 ccgagtataa ttcaattcga ttgtttcatc tgtaacaaaa cggtatgata gaagaaacaa 1024981 tcgaatgaaa aaggatggaa aacccgatga acacagatca tacgaaacgc aatctttttg 1025041 aattgtatgc ggagctcatt catcagcagg agaaatggga ggggcttatt aaagcctttt 1025101 tatctgacga attgaggaag ctggatgtag agcacgggag taaatctcaa ttgacgatga 1025161 cagaaattca tgttctatcc tgtgtcgggg acaatgaacc aattaatgtc acgtcgatag 1025221 cagaaaaaat gaatacgaca aaagcgactg tatcacgcat cagcacaaaa ttgctcggcg 1025281 caggcttcct tcacagaaca cagctcagcg ataataaaaa ggaggtctac ttccgattga 1025341 cgcctgctgg aaaaaagctg cacagtttgc acaaatatta tcatcagaag gctgaacagc 1025401 gttttctgtc attttttgac cgctataccg aggaagagat tctttttgcg gaacggctgt 1025461 ttcgggatct ggtgacaaaa tggtatccgt cgtcagaaga aattgaaggg gggcttccta 1025521 gcatttttaa ataaaaaaca cgcactgcgg tgcgtgtttt tcgctttgcg gccgcctcga 1025581 gaattctttc atttcaccct ctggcagcac tcacttcaaa tctgatccat taacaacgaa 1025641 atatccgctt atatttcctc atctcgatgg tttgcgaatt aaaagttctt gaaccctttt 1025701 ttcaactagg cactactgcc gctgattgag ctctttttgt cttttttttc accatgaaga 1025761 tggtgaagca ggcgataaaa cggcggcagc agggcaataa ccagaatgac gcgaatgacc 1025821 tgaaccgcaa cgacaaaggt ggaatcagca tgtaaggtaa ctgacgtcgt cgccatctct 1025881 gcaatcccgc cgggcgcaaa tgccagaaca gaagtgatga gcgaaattcc tgtcagctcg 1025941 gaaacgatca cggcgctcaa aaacattgct gcgattaaac cgacggacga gacaaacccg 1026001 acgatgataa tacgggtgac gccggcaaac atgcttttgt acatcttaga gccgatcgtt 1026061 gccccgagaa atacttgtga tacatggtta gcttgtgaca accaccatgc cgtcatgtcg 1026121 tgccctgtca ccgcagctcc gccaacatgt acaattgcta caccgagcat gctgccgagc 1026181 agccatggag ctggaaattt taaaaatttc gcagctttgc aagctcccca ggcagcgaga 1026241 ataagaatga cggtccacaa aacgggagcg agcctaaaat ctgtcgttgc agaagaaatc 1026301 gtctctgctg cggcacttgc ggtacgatct tgttttgtat agatcagaat gactaaaaac 1026361 ggaatggaaa gcaccacgag cagcacacgc atcatttgaa cgaggctgac tatagcggta 1026421 ttggcgccta cttcctgtgc gatgctcggc atggcggaaa gtccgccggg agcggtgccg 1026481 acaaagctag tcatcatatc cgttttgctg aaacgccaaa gcacatatcc tgacagcatg 1026541 gccagcagga tagacaatat cagcataacg ccgactgaaa accaatggtc tttgagaaca 1026601 gagagaacgg ataaattcag cttttggccc aattcgatgc cgaggatcat ctgcccgagg 1026661 gcgagccatc gtcggttaat tcctttttgg tctggtgcca tcatcagcca tgccggccgt 1026721 atcatggcga ggcagcaggc gacaatcagt gttccgatca tccatccaat tgatattccg 1026781 gttaatgaaa gaataaaccc cccggctgca ctgattgcga taaaccatag atctttgagg 1026841 agattttcgt ctttcttcaa tgtaaaaccc ttcttccttt ttcacgtaac actccaattg 1026901 ttcacgtagt gaatgtattt attactatag tatatttttg ttgataaaga aattatgaat 1026961 tattttctat aagcgattca cttttcttat gaccttgtgt tcgagctttt ctattgtgta 1027021 agtcagagat aaacccgctg tcagcagaca cacggcaaga gcgtaaaaaa tcacttctcc 1027081 gccaaatgat gtcaggatca gcccgcctgc cagcggtccg attgagcggg atatatccca 1027141 atgcagacca tagacagcat aaaaccggcc cagcaaatga ggcggcgcca atttcgatat 1027201 gaaggtctgg atgtgggtta gcccgatgct ttcaccaacc gtcatcaccg ctgccgtcac 1027261 taaaagcatt gtcagagagg ttgagcatgc aaagccggct gccgcaaggg agtagcaaat 1027321 ataagtaatg aagaggatcg ttttcattga aagcttttcg gtccctttga caagaggtac 1027381 ttggagaaca cagctgaata aagcttttgc tgctgaatag atggtcagca tggacagata 1027441 atcagaaaac atgtttttgc tgaacagcct gtatgttgtt tctgtttgtg catataacat 1027501 gctgatgggg agagaaagca gcaaaagaag caggacaggc ctgtatattg taaagctcgc 1027561 ggacattttc ggggtaacag ctgggtgtag cggctttgtc tcaggcagtt tcagtgcagc 1027621 gatcagaaag tagataaaca atgctgcagc atctaatgcg aatatccaca cggggttatg 1027681 attgtacagc agcatcccca ctagcggtcc tgccgtcaga cccgtcgaat agatcgcatt 1027741 gatgaccgca aacacttccg aacgtctgct ttccggcgtg ctttcagcga tttgggcgcg 1027801 ggaagcggga atgtacaacg atcttccgat gccattcatg acatagagaa tagcgaaaac 1027861 atacgcatgc tcagcaaata caaaccctgt cattgccgct gattgaagaa gcaatgcggt 1027921 caaaatcgct gtgcgccgcc caagccgatc cgtcacccgt cctgcagcga gcgtcaggaa 1027981 aatatcagca aatggctgaa ggctgatgat cagcattggc atcatgatac tgccgtttaa 1028041 ttgttcatgc agatacagca ccataaaagg tcccatcatt gcacctgtca ggcttgtcag 1028101 caattcgccg aaaaagcgga gccgaacggg agcggtatat ctcgatttta tagagtgaaa 1028161 actggtcaac atgtgatcgc cgcctttcgc tgtttgatat agtagtagtg tatagaaggg 1028221 gcggcggccc aaaaagtgaa gaaaagaaga gataaaagtt ccccttttgt cgggaggtgc 1028281 ggggattgaa gctgatagag cactacgtgg cgcttgtaaa aacaggctgc gccgagtatg 1028341 ggcaaatgaa cgaaatgacg ctcactgaga ttgccgactg tttattttgt acagaaagaa 1028401 atgcaaagct cattttacat aagctggaga acagcaattg gattatccgg gaaagcgggg 1028461 cggggcgcgg ccgcaaatct aaaatcgcgt ttcttcggag gcctgaggaa ctgcttcttc 1028521 aaactgcaaa ggaatatacc atgtcaggaa agcttaaaaa ggcaaaggag ctgcttcagc 1028581 agtatcagtc cgcgtttcca gggcttcaaa acgaatataa catgtggcta tcagaggtat 1028641 tcggatttgt gacggagaca ggcgagaatg gggcgaagga tgtcctgcgg ctgttcatca 1028701 cgcctgaatc tgtcagcagt ttggatccat gccaaatatt tttgcggtct gagggccatt 1028761 tcgtcaaaca gatatttgat acactcttca cgtttgattc ggatatgcag gagccgaagc 1028821 ctcatttggt tcatggatgg gaagaggtcg gaaaaaaaca atggagattt tttcttcgaa 1028881 aaggtgtgtt atttcataat ggacagccgc tgacatcgcg ggacgttgcg tttacatttc 1028941 agcgcttttt ggaactggct gacaacccgt ataaatggct tctgcacgga gtgaaacaag 1029001 tcttagaaaa gggcccttat tgtgtggagc tcatactcga taagccgaat gcgcttttgc 1029061 cgtatgctct ttgtgatgaa cggctgtcca tactgccggc agaacagggc ggcgggaaaa 1029121 atggaacagg gccttttcag atgaatcagc aacatagcgg gatgcttgtg cttgaagcca 1029181 atgagcgcta cttcaaggga cgcccctatt tggatcgcgt tgagtttgtg ttttctgagc 1029241 aagccggaga gatgaacggt tttaccattc aagaaaaaca aacatgtcct gagcagcaaa 1029301 ctgtctttga tgagcggcat gttcagtatt tgtcgcttaa tctgaaaaag aaggggcctc 1029361 ttcagcaccg aagctttaga aaagcgctcc ggctgctgat ttcctctgaa cggctcgttc 1029421 gtgaagcggg agggcaccga agaattccgg ttacgtcctt tttgcatccg agtccttttg 1029481 agtgggaggg cgtttcgcca tctgaattgt tgaaaaaaag cggatacgag ggcgaaacaa 1029541 tcgtgcttta taccttttcg gaaacggatc atcgtgagga cgccgaatgg attcaaaata 1029601 tttgcgccca gcacggtatc aggcttacac ttcaattctg tgatgctgct gatctgcgac 1029661 ggccggaaat cgtgcagatg gcggatatca ttcatgacag tgcgacgttt tatcaagaca 1029721 gcgagtttgg ttttctgcat ttgctgctgt cggagaacag tttcttgtat cagcatctat 1029781 ctgaaaagct gacacagatt tgctcaggaa tgacagagcg gatgttttcc atgcctgacc 1029841 gctgttcgag aatcaacatc ctgcgtgaca ttgaccggca gatgatacag gagctgaacg 1029901 cgatcccgct gtatcaaaat gtgctccagg tgacatcaag taaaaatgta aaaggcctgg 1029961 tgcttgatga agagggatgg attgatttgt actccgtatg gctgtccaaa taaaaagagg 1030021 gttctttttt gaaccctctt ttttacgctg ccatgctgcg gcattgttca gcacaggtga 1030081 agcaggcttt cgcacatgct tggcaatgat catgatcgtg ctttccgcat tcagtgccgc 1030141 atgcttcaca aatatcggcg caaagtgcac aaatttcttt cataaacggg ctgtccgttt 1030201 gcatggcttt gaccgccagc gcgcaaatat ccgcgcattc cctgtcaagc cggatgcatc 1030261 cgctgagatg atgctgcacg ctttcttcca agcatttagt gaaacaatga ttgcaagcct 1030321 tcatgcaatc gatgcaagcc tcaatacaag cctcagaata ttgctccatg gttgattccc 1030381 cctgtatgac agtatatggt tttatgtttc acggctgcat ttgaaaaaaa caggggagtg 1030441 tgtttttagc taaggggata tgtacatata ccctgaatgg gtatatctaa cgttccatca 1030501 gatagtatag gaaccagaca gcgtgatttt gttcatcacg tgctgcgcgc gtaaagacgc 1030561 ctttcgcttt taagtttgac gtttcctcgg ccgcacgcaa gtaaaagtcg acggtttctt 1030621 gttcatcttt aaaagcggcg tccagtcctc ttgtgaaatt gtccgggcat tcttccgttt 1030681 gtttcggcat gatgtgtttg ccggtaattg aaccatacag tgtggaaaat tcacggaggt 1030741 ggcgaatctc gtcacgcctg atttcttcaa tctgttttct gacctcatcg ctgtgggcga 1030801 gttcggcaag cttgcggtag cattgaatag cactgaattc tccgttgatg gccttctgca 1030861 aattccgaat caaaacagga tcttcccggt atggcaccgg atagggatag tagctgtaat 1030921 gcaaggggat tcaactccat tcttaggaat tgggcttctg taaaagtata tgttgggcag 1030981 ggagagatgt gcggagataa tcagcttttt atatgtgaaa aggccgtttt taccaataga 1031041 tcagattggt cattttcgtc aacattcgat aaaatataga gagataaaaa gagaggggtc 1031101 ttctaatttg ggagcagagt ttttagtagg caggtccggg agtggaaaaa cgaagctgat 1031161 catcaacagc attcaggatg aattgcgccg ggctccattc gggaagccga tcatttttct 1031221 agtcccggat caaatgacgt ttttaatgga atacgagctt gctaaaacgc cagatatggg 1031281 cgggatgata cgcgctcaag tgttcagttt ttcacgattg gcctggcgcg tcctccagca 1031341 tacgggagga atgagcaggc cgtttctgac gagcaccggc gtacaaatgc tcctgcggaa 1031401 gctcattgag gagcataaac aggagttcaa agtctatcaa aaagcgagtg acaaaagcgg 1031461 gtttaccgca caggttgagc ggatgctgac agagtttaag cgctattgtc tggaaccgga 1031521 ggatatccgc cggatggcgg aaagcggaac ggcttccgag tatcgcggag aacgtgtttt 1031581 atctgaaaag ctccatgact tatcaattct gtatcagcaa atggaaaaaa gcctcgcaga 1031641 tcaatatctt cactctgagg attatttgac attgctggca gagcatatcc cgcttgcgga 1031701 agatataaaa ggcgcccata tctatgtgga tggcttttat cagtttaccc cgcaggaatt 1031761 cagggtgttg gagcagctta tggttcatgc ggagcatatc acgttttcgc tcacagcgga 1031821 caagccgtca tatgagcggg agccgcatga actggaattg ttcagaatga cggggaaaac 1031881 ctattaccgc ctgcatcaga aggcgaagga actgaatttg gacattacgt ataaagagct 1031941 gagcgggact gagcggcata caaagacgcc ggaattggcg catctagagg cacagtatga 1032001 agcgcgtccg gccattccat acgcagaaaa acaagaagcc cttactgtga tgcaggccgc 1032061 aaacagacga gctgagctgg aaggcattgc tcgggaaatt cacgccctag tcagagagaa 1032121 gggatatcgc tataaggatg tagcaattct tgcgcgccag ccggaagact acaaggatat 1032181 ggtgaaggaa gttttcgcag attacgagat tccttatttc attgacggaa aagcatctat 1032241 gctgaaccat ccgttaattg aatttatccg gtcgagcctt gatgttctga aagggaattg 1032301 gcgttatgaa gcggtgtttc gctgcgtgaa aaccgaactg ctattcccgc tcaatgaacc 1032361 gaaggccaaa gtgagagaac aggtcgatca gctcgaaaat tactgtatcg cctatggtat 1032421 taaaggcgac cgctggacaa agggcgatcg gttccaatac aggcgttttg tgtcattgga 1032481 tgatgatttt gcgcagactg atcaggaaat cgaaatggaa aacatgttga atgacacccg 1032541 cgattggatt gttccgccgc tttttcagct tcaaaaacgc atgaaaaaag cgaagacggt 1032601 tcaagagaag gcggaggcgc tctatcgtta tttagaagag acggatgtgc cgctgaagct 1032661 ggatcaggaa aggcagcgtg ctgaggatga cggcagaatc attgaagcgc agcagcatca 1032721 gcaggcgtgg gacgcagtca ttcagctgct tgaggagttt gttgaaatga tgggagatga 1032781 tgagatttct cttgatttgt ttcagcaaat gatagaagcc ggcgcggagt cgcttacatt 1032841 ttctctaatt ccgcctgcgc ttgaccaggt gtttgtcggc aatatggatt tgtccagaat 1032901 gtatggcacc tcctgcacct ttgtgctcgg ggcaaacgac ggcgttctgc cggcacgccc 1032961 tgatgaaaac ggggtcctgt cggatgatga ccgggaatgg ctgaaaacga ttggggttga 1033021 gctatcctca ggcggacgag agcgtttgct tgatgagcac ttcctcatct acatggcgtt 1033081 ttcaagtccg tctgaccggc tttacgtatc gtatccgatt gctgatgcgg aaggaaaaac 1033141 gcttttgccg tcgatgatcg ttaagcggct ggaagaactg tttccgcatc ataaggagcg 1033201 cctgttaaca aatgaacctg aacaggtcag cgatgaggaa cagctgatgt atgttgtgaa 1033261 taaaagcgtg gcacagtcct ttaccgcgag ccagctcagg ttatggactc gggaatacga 1033321 catcagcgac gtctggtgga gcacgtacaa tgtgctgatg agtgagcagg acaggctgca 1033381 atcgaaaaag ctgttctcaa gcctgttttt ccggaatgaa gtgaagcagc ttgaacgcag 1033441 cgtgtcgaga cagctctatg gtgaacgtat tcagggcagt gtatcgagaa tggaaacctt 1033501 taacgcatgc ccgttttccc attttgcgtc acacgggctg catttgaagg aacggcaatt 1033561 cttcaagctt gaagcaccgg atatcggcca gctgtttcat tccagcttaa agctgatttc 1033621 ggacaggctg cgtgagcaaa agctggattg gcgcgattta acgaaggagc agtgcgagct 1033681 gttttcctat gatgcggtag agcggctggc accgaaactg caaaaggaaa ttctgctcag 1033741 ctcaaaccgg cattattatg tgaaggaaaa actgcaaaaa attgtgacac gtgtgtccgg 1033801 cattttaagc gagcatgcga aagcgagcgg attcgtaccg atcgggcttg aactgggctt 1033861 tggaggaaaa gggccgcttc cgccgctgac ctttcaactg aaaaacggct gtacgatgga 1033921 actcgtcggg cgaattgacc gtgttgataa ggctgaaagc tcaaaaggcc tgctcctcag 1033981 gattgtcgat tataaatcaa gcgacaaagg ccttgactta gcggaagtat attacggatt 1034041 ggcactgcaa atgctgacgt accttgattt atcgattaca cattcagctg actggctcgg 1034101 gatgagggcg acgcctgccg gagtgctgta tttccatatt catgacccga tgattcaatc 1034161 taatctcccg cttgggcttg acgagattga acaggagatc tttaagaaat ttaaaatgaa 1034221 gggcttgctc ctcggtgatc aggaagtggt tcgcctcatg gatacaaccc ttcaagaggg 1034281 acgttcaaat atcataaacg ccggcttgaa aaaagacggc tctctcagat cagactcagc 1034341 agcagtcggt gaaaaggaat ttgatctttt gacaaagcat gtgcgccgca ccttccaaga 1034401 agcgggcgaa caaatcaccg acgggcgcgt atccattgag ccgtacaaaa tgaagaacaa 1034461 gacgccgtgc acatactgtg cgttcaaatc agtatgccaa tttgatgaat cactggaaga 1034521 aaacgagtat cgcccattaa aggctgaaaa ggacaagaca atacttgagt ggataaaaaa 1034581 ggaggcggat ggcaatgaac attcctaaac cggcagacag cacatggaca gatgaccaat 1034641 ggaatgccat tgtttcaacc ggccaggata ttcttgtggc agcggctgcg ggctctggta 1034701 aaaccgctgt gctcgttgaa cgaatgattc ggaaaatcac cgcggaggaa aacccaatag 1034761 atgtagaccg tcttctcgtt gtgacattta caaacgcctc agcggcagag atgaagcacc 1034821 gaatcgcaga agccttggaa aaagagcttg tacagcgccc cggctcgctg catattagac 1034881 gccagctgtc tcttttaaac cgggccagca tttcgacgct ccattccttt tgcctgcaag 1034941 tgctgaagaa atattactac ttgatcgatc ttgatccggg ctttcggata gctgatcaga 1035001 cggaaggcga gctgatcggg gatgaagtgc ttgacgagct gtttgaagac gaatacgcaa 1035061 agggcgaaaa ggcgtttttt gagcttgttg accgctatac gacagaccgg catgatctgg 1035121 atctgcaatt tctcgttaaa caggtgtacg agtattcccg atcccatccc aacccggagg 1035181 cgtggctgga aagctttgtt catttgtatg atgtatcaga aaagagcgcc atcgaggagc 1035241 tgccgtttta tcaatatgtc aaagaagata ttgcaatggt gcttaacggg gcgaaggaaa 1035301 agctcttgcg cgcgcttgag ctgacgaaag cgccgggcgg cccggcgccg cgtgctgaca 1035361 attttcttga tgatcttgct cagattgatg aactgattca gcatcaggac gatttcagtg 1035421 aactatataa gcgggtgccc gccgtctctt ttaagcgtgc caaagcagta aaaggggatg 1035481 agttcgatcc agcgctcctt gatgaggcga cagatttgag gaacggcgca aaaaaactgc 1035541 ttgaaaagct caaaaccgac tacttcacgc gaagtcctga acagcacttg aaaagcctag 1035601 ccgagatgaa gcctgtcatt gaaacgctcg tacagcttgt catcagctat ggaaaacgat 1035661 tcgaagctgc gaaacaggaa aaatcaatca tcgatttttc ggatttggag cattactgtt 1035721 tagcgatttt gacagctgag aatgacaaag gtgaacgtga gccgagcgag gctgcaaggt 1035781 tttatcagga acagtttcat gaggtgctcg ttgacgaata tcaggatacc aacctcgtgc 1035841 aggaatcgat tctgcagctc gtcacaagcg gtccggagga gactggtaac ctgtttatgg 1035901 taggagatgt caaacagtcg atttatcgat tcaggcttgc ggagccgctt cttttcctct 1035961 ctaaatacaa acggtttaca gagagcggag aaggcacggg gcggaaaatc gatttaaata 1036021 aaaatttccg aagccgggct gatattttag acagcacaaa ctttttattt aaacagctga 1036081 tgggcggcaa aatcggtgag gtcgattatg acgagcaggc tgagctgaag cttggtgcag 1036141 cgtatccgga caatgacgag acggaaacag agctgctgct gatcgacaac gcagaagata 1036201 cggatgcaag cgaggaagca gaagagcttg aaacggtgca gtttgaggca aaagccatcg 1036261 ctaaggaaat tcgtaagctg atttcatcgc cgtttaaggt gtatgacgga aaaaagaaaa 1036321 cacatcgcaa tattcaatac cgagatatcg tgattttgct ccgttcgatg ccgtgggctc 1036381 cgcaaatcat ggaggagctg agagcacagg gcataccggt ttacgccaat ttaacgtcag 1036441 gctattttga agcggtcgaa gtcgccgtcg cgctttctgt gctgaaggtg attgataatc 1036501 cgtatcagga tataccgctt gcctctgtgc tgcgctcacc gattgtcgga gcagatgaaa 1036561 acgagctgtc tttgatccgg cttgaaaata aaaaagcgcc gtactatgag gcgatgaaag 1036621 actacctggc tgctggtgac cggagcgatg agctttatca aaagttaaat acgttttacg 1036681 gacatctgca aaaatggcgc gcgttttcga aaaaccactc agtatctgag ctgatttggg 1036741 aagtgtaccg cgacaccaaa tatatggatt atgtcggcgg catgccgggc ggaaaacagc 1036801 gccaggccaa tttgcgtgtt ctttatgaca gggcgcgtca atatgaatca acggcatttc 1036861 gcggcttgtt ccgtttcctg cggtttatcg aacgcatgca ggagcggggc gatgatcttg 1036921 gtacggcgag agcgctcagc gagcaggagg atgttgtccg cttaatgacg atccacagca 1036981 gcaaagggct cgaatttcca gtcgtgtttg tagcaggtct cggccggaat ttcaacatga 1037041 tggatttgaa caaatcgtac ctgctggata aggagctcgg atttggcacg aagtatattc 1037101 atccgcaatt acgcatcagc tatccgacac ttccgctcat tgcgatgaag aaaaaaatgc 1037161 gcagggagct gctgtcagag gaattgcgtg tgctctatgt tgcattaacg agagcgaagg 1037221 aaaagctgtt tctgattggc tcatgtaagg atcatcagaa acagcttgca aaatggcagg 1037281 catccgcgtc ccaaactgat tggcttctgc cggaatttga ccgctatcag gcgagaacgt 1037341 atctagattt cattgggccg gctcttgcca ggcacagaga cttgggggat ttggctggtg 1037401 tgccagcaca cgctgacatc tcaggtcacc cggctcgttt tgccgttcaa atgatccatt 1037461 cctatgattt gcttgatgat gatctggaag aaagaatgga agaaaaaagc gagcgcctag 1037521 aagcgatccg ccgaggtgaa ccagttcccg gctcgtttgc gtttgatgaa aaagcccgcg 1037581 agcagctgag ctggacctac ccgcatcaag aagtgacgca aattcggaca aagcaatcag 1037641 tttctgagat caagagaaaa agagagtacg aggatgaata cagcggcagg gcccctgtaa 1037701 aaccggctga tggaagcatt ctgtacagac gtcccgcttt tatgatgaaa aaaggcctga 1037761 cagcggcaga gaaagggact gccatgcata cggttatgca gcatatcccg ctgtcacatg 1037821 tgccgtcgat agaagaagct gagcagacgg ttcacaggct ttatgaaaaa gagcttctca 1037881 ctgaagaaca aaaagacgct attgatatag aagaaatcgt gcaatttttc catacagaaa 1037941 tcggcggaca gctgatcggt gctaagtgga aggaccggga aataccattc agcttagcgc 1038001 ttccggccaa ggagatctat cctgatgcac acgaggcaga tgagccgctt ttagtgcagg 1038061 gtattattga ctgtctctat gaaactgagg acggattata tctattggat tataagtcgg 1038121 accggattga gggcaaattc cagcatggat ttgaaggagc ggccccgatc ttgaagaaac 1038181 gatatgaaac gcaaattcag ctgtacacga aggcagtgga gcaaattgca aaaacaaagg 1038241 taaagggatg tgcgctttat ttctttgacg gagggcacat tctgacatta tagcgagatc 1038301 cataagctcc ggaatttcag gcggagcggg tctcgttttc tatataaaag agaggtgaaa 1038361 gcatttgcgg attttacata cggctgactg gcatcttgga aaaacgcttg aaggaagaag 1038421 caggctgagt gaacaggccg atgtgctgga tgaactgaat acgattgtaa aggatgagca 1038481 gatcgatgcc attgtaatgg cgggggatgc atttgacacc gtaaacccgc cagctttagc 1038541 cgagcagctg ttttatgaaa gcctgtctgc gcttagcgac agaggaaagc gcccgatcgt 1038601 cgtcattgcc ggaaatcacg ataatcctga ccgtttgtcc gccgcttcac cgctgacaca 1038661 tgaaaacggc attcatttaa tcggttatcc gacaacagag ccgattcata ttgaagtgcc 1038721 ttcagcagga gagcttttgg cggttggagc gctggcgtac ccatctgaag cgcggttaaa 1038781 tgaagtgcta tccgatacgt ttgatgaaaa gctgctccgt gatcactatg atgtgaaaat 1038841 caggcaggcg tttgagcata tgacaagccg gttccggacc gatgcagtga agattgccgc 1038901 cagccatatt tatgtggcag gcggaaacca aaccgattca gagcggccga ttgaagtcgg 1038961 cggtgcatac acggtggctg ctgaaagcct gccggcagat gccgcttacg ttgcgctcgg 1039021 ccatttgcat cgcccgcaaa cgatcaagcg ggcgcggacg cttgcgcgtt attcaggatc 1039081 tccgctcgcc tacagctttt ctgaagcggg ctacgctaaa tcagtgacga ttgtggacgc 1039141 aaagcctggg gaagaggcca cttggcaaga ggtgttatta tcaagcggca agccacttgt 1039201 gaagtggaaa gcggcaaatg gattaagtga ggtgtacagc tggctggatg aaggcagaga 1039261 tcagaatgct tggattgact tggaaatccg tgtcgcggac cagctgtcac ttgaagagat 1039321 tcacaggctg cggaaggcgc acccgggctt tatccatatc aggccggttt ttgaagaaca 1039381 gaacaaagac cgggaacgga tcgaggttaa acatgtctca atcgaggacc gctttaagaa 1039441 attttatgaa aaacaaactg gcggtgcggt gccggatgaa gaaatggtga agctgttttt 1039501 agagcttgca tcaggcgttg aagaggagga tgcgaaatga agccgatcgc cttaagcatt 1039561 aaggggctcc acagctttag agaggagcag acgatagatt ttgaaggcct ttccggtgcc 1039621 ggtgttttcg gcattttcgg cccgacagga agcggtaaat cctctatact cgacgcaatg 1039681 acgcttgctt tatacggaaa ggtggaacgg gcggcgaata atacgcacgg aatcttaaat 1039741 cacgccgaag atacgctgtc tgtgtccttt acctttgcgc ttcagacgaa tcaccaaatc 1039801 tcatacaaag tcgagcgtgt gtttaagaga acggatgaaa tgaaggtaaa aacggcactt 1039861 tgccgcttca tcgaaatcaa ggacgagcat acggtgctgg ctgataaagc cagcgaagtg 1039921 aataaaagag tggaggagct cttagggctg acgatcgacg attttacgag agcggtggtg 1039981 ctgccccaag ggaaatttgc tgaatttctg tctttaaaag gggcagagcg caggcatatg 1040041 cttcagcgtt tatttaattt ggagcaatat ggagacaggc ttgtgaaaaa gctgagacgg 1040101 caggcgcagg aagccaatgc gagaaaaaat gaaatgcttg ctgaacagtc cggtctcggt 1040161 gaggcgagct cagaggcagt ggagcaggct gaaaaggttc tcgaacaagc tgaagcccgg 1040221 ctggaagcga tgaggaagaa ccgtgatcag gcgaaggagc ggtttacaga gcatcaggag 1040281 atatggaatg tccaaaagga aaaatccact tatgaagaag aggaaaaacg tctcgcagaa 1040341 gaacagccgc atatagacag catgcaaaaa cgcctgctgg aagcagaaac agcagcagcc 1040401 cttaagccct atgcggaccg gtacgcagaa gcgatccagc atgaggagca agctgaaaag 1040461 gaacaaacgc tagcccaaaa ggatttagca gaccggacag ctttctttca gcaaaaacat 1040521 gaagagtatg aagcgtggcg ccagcataaa agcgagaaag agcctgagct tttagccaaa 1040581 caggaacagc tttcacgctt gcaggaaatc gaaatcaaac tgagtgaggc caagcaagag 1040641 gaagagcgca aaaaggctga cctccggcag aaagaagagg ctcttcaatc tgtcatgaat 1040701 gaattagaga ccgtaacaga ccgcctgaca cgagggcaaa acagacagac agaattgaag 1040761 cagcagctca aatccctgca ggtgacatcc gatgagcgaa aaagctgcca gcaggccgca 1040821 gagatggcat tgcgcatcag acaaaccgag gaacaaatca aaaaagagaa aaaacgaagt 1040881 gaagaattga acctcgtgct gcagaagatg aatgaagaga agaatacact cgttcaaaag 1040941 acggaagcgg aagaaaacaa catcattcag gcatatgagg cagttcaaac tgtgtaccat 1041001 ttggtgtgcg aaacggaacg ctcattaaca cgtatgacgg aagaggctag aaagagtcaa 1041061 cacacgcttc acttacagcg tgaaaaagca agggtggcac tgctgacaaa agagttagcc 1041121 caaaagctga ctgccggaaa gccttgcccg gtatgcggtt caaccgatca tgatccatct 1041181 gcctcggtac atgaaacgta tgaagccgac agccatcttg aagaggacat caaacggaca 1041241 gatgtgttat tgacggaagc tgcagctctc agccaggaga ttctttcagc caaaattatg 1041301 cttgaagaac agtccgcgcg ctttattgaa cagtgtccgt ttttgcagac aattcaagca 1041361 cagaaccttg aagcggcagc ttccttcgaa catcagccgg tgtatgaagc atttgaaact 1041421 gccaaatttg aatggaaacg aatcaagcag gacattcttt ctgttaagac acgaatggca 1041481 caaatgattg gcgcctatca ggagtcttta aaaaaggccg agcagcttaa tgaaaaaatc 1041541 ggttttgaaa aaagagaagc cgaccgtatt gaaagcatca tcagtgagct tcaatcctca 1041601 atggacagca gtctgaacat gtttaaagaa gcatttcaga atcaatctgt ggacgaagca 1041661 gaaaaatggc agcaagccat tgaagaaaag gaccgggctg cagaagaatg tgaaaaacga 1041721 attgagaaga gtatcgcgtt tcttgctgag catgaagcac aaaaggaaaa actgcgggaa 1041781 tcgggacacc ggcttgagcg ggaaaagctg gagcttcatt atgcggctga acgcatcaag 1041841 agcgtgatag ctgattatga gcacgaactc ggagattatg caaaaggaga ttcgattcaa 1041901 atcaaactcc gctctgtcca gcaggatcta aagctgttaa aggaaaaaga acaatcttta 1041961 tatgaagaac tgcaaagcgc ccaaatgaag ctcaaccaag cgaaaagccg cgcttctgca 1042021 agcgagctca ctcttcaaga ggcgaagggc agattggaaa aagcaaaagc tgcttggctt 1042081 gagcatacaa aaaacacctc cattacccgg actgaggagg ttgaacaaag tctcatccca 1042141 gctgatgaac ttgaaaagat gaaaaccggc atagaccagt ttatggataa actgaagcaa 1042201 aatgctgcaa acttaaaacg agtagcagag atacttgccg gcagagcatt atcagagagc 1042261 gaatggaacg aaaccgttgc agcattacaa gaagctgagg acgcatttgg cgctgctata 1042321 gaggaaaaag gcgcggccgc aaaagcactg gctgtcattc gcgaccatca taaacggttt 1042381 aatgaaattg aagctgaact gaaaaaatgg cagatgcata tcgacaggct ggacaagctg 1042441 caagctgtgt ttaaaggcaa taccttcgtc gaatttttag ctgaggagca gcttgaaagc 1042501 gttgcgaggg acgcctcagc aagactcagt atgctgacaa gacagcgcta tgccatcgaa 1042561 gtagattctg agggcggctt cgtgatgcgg gatgacgcga atggaggcgt acgacgcccg 1042621 gtttccagtt tgtctggagg agagaccttc ctcacctcgc tttcacttgc tcttgcgctg 1042681 tctgcgcaga ttcagcttcg gggggaatac ccgctgcagt tctttttctt agatgaaggc 1042741 ttcggcacac tggatcaaga tctgcttgat acggttgtaa cggccttgga aaaacttcag 1042801 tcagacaacc tggctgtcgg tgtcatcagc catgtgcagg aactgcgtgc acggcttccg 1042861 aaaaagctga tcgtccatcc ggctgaaccg agcggccgcg gtacgcgggt atcacttgag 1042921 ttgatgtaag ggaggagcgg atatggcaaa gcagattgcc ggaatatgtg agctgtgcgg 1042981 ccggagcgat gtccagctga cagagcatca tcttacaccg aaagaggaag gcggaacgtt 1043041 tttgccgaca gcgatgctct gtattccttg tcataaacag attcatgcct tatataccaa 1043101 tcaagagctc gctgtacgtt taaatggaat ggctgaactc agaagcgatc cagagcttgc 1043161 ccggtttgtc aaatggatca gaaaacagcc gcctgagaag ctgatcaaaa ctaagaaatc 1043221 aaatgaacga aaaaagaaaa aatgactaaa aagcagccct ctctttgcag agcggctgct 1043281 tttatccgtt tccaaccata tccggaagca aaagttgttg ttgaaaagta accaaaaagc 1043341 ggtgctcgat gcaccgcttt tttatttgcg cccccgttgg actgctgtgt acataatgga 1043401 tcgctttccg tttgaagccg tccattcaaa acggtctcct gtcccttcgc tgctgtagtt 1043461 gtagtgatgc tgcatcgcgc attgtgcggt gtcatttgaa aagtgataaa aggacacacc 1043521 ctgccccgcc gaagtattcg aaaagactcc tttattataa gaaaagacgc aatcgaatac 1043581 cgataagccg aagctgtgca agtgctgcag aaatgcgaga aaggtttcgt cgtcaagcga 1043641 atccaaaagc gccatgagcg gccgcttgac tgatttctca tagcggatgc gttctccgcc 1043701 ggaaagggag atgttttctg caccgcatgc caaaaccaac ttgtcctgaa agccggcttg 1043761 ctcccacttt cctttatgat ggatccagat tgggctgtgt tggagactgt ccgccagcag 1043821 tatatcgcct tcaccgtttt cgattaagca gatgccgtct tcaatgagga tggtgccgta 1043881 ttcccacttt cgttcctctg tatataacaa ttgtttccgt ttcatccatg ctgtctcctt 1043941 tttcttcatt cctctctttt ctttccaatt caagcctgtc ccatacaact cttttatgga 1044001 caaatcaact atctgcctat agatgcataa acttactaag gtgctgaaag aaacgaaatt 1044061 gttacgaaag aaacgggatt ggagctgatg tcacatgtgt ggaattacgg gttgggtcga 1044121 ttttaaaaag cagctcgtcc aggaaaaaca aacgatggac agaatgacag acactctttc 1044181 caaacgaggg cctgatgatt caaacgtttg gggggagcac catgttttat tcggacataa 1044241 aagacttgcg gttgttgata ttgaaggcgg acgccagccg atggcgtgta cctataaagg 1044301 cgatacgtac accattattt acaatggcga gctttataac acggaagatt tgcgcaaaga 1044361 attgcgggcg cggggccatc aattcgagcg tacgtcagat accgaggtgc ttctgcacag 1044421 ctacatcgag tggcaggaag actgtgtcga ccatctcaat ggcatattcg ctttcgctgt 1044481 gtgggatgaa aagcgtaatc tgttgtttgc cgcgagagac cgtctcggtg taaagccgtt 1044541 tttttacacg aaggaaggct cttcatttct cttcgggtcg gaaatcaaag caatcctcgc 1044601 gcaccctgat ataaaagcgc gagtggacag aacgggactt tctgaaattt tcggtcttgg 1044661 accgtccaga accccgggca ctggcatatt taaaggcata aaagaaatcc gcccggctca 1044721 cgcgctgaca ttttccaaag acggacttaa tatttggcgt tattggaatg ttgaaagcga 1044781 aaaacatacg gacagttttg atgacacggt tgccaatgtc agatcgttat ttcaggacgc 1044841 ggtgacgcgg cagcttgtgt cggatgtgcc tgtttgcaca ttcctatcag gcggtctgga 1044901 ctcaagcgcg attacagcga ttgcggcggg ccattttgaa aaggaaggaa aagcaccgct 1044961 tcatacttat tcgattgatt acgaagagaa cgataaatat tttcaagcaa gcgcttttca 1045021 gccgaatgat gacggaccat ggattgaaaa aatgacagag gctttcggca caacgcacca 1045081 caaatgcgtc atcagccaaa aagacctcgt tgatcatttg gaggaagctg tactggtcaa 1045141 agacttgccg ggaatggcag atgtcgactc atccctgctg tggttttgcc gggaaatcaa 1045201 aaaggacttt gtcgtcagcc tatcgggaga atgcgcggat gagattttcg gcgggtaccc 1045261 gtggttccat acggcagatg ttgagtctgg ctttccatgg atgagatcaa cggaggagcg 1045321 gatcaagctg ctttctgact catggcagaa aaaattgaat ctgaaagaat acgtaaatgc 1045381 caaatatgaa gaaaccttgg cagaaacgcc attattagac ggagaaacgg gtgtggataa 1045441 agcaagaaga cagctgttct atttaaatat gctttggttt atgacgaacc ttttggatcg 1045501 gaaggatcgc atgagcatgg gggcgagcct ggaagtgcgg gtgccgttcg ccgatcaccg 1045561 gcttgtggaa tatgtttgga atattccgtg ggaaatgaaa atgcatgata atcgggaaaa 1045621 aggcattttg cgcaaagcgc ttgagggcat tttgcctgat gacattttgt atcgcaaaaa 1045681 aagcccatat ccgaaaacac atcatccgga atatacaaaa ggcgtcagcg agtggctgaa 1045741 aacgatcaga agccaaaagg actccgtgct ccatacctta ctggacagaa aacaattaga 1045801 tcagctttta gaaacggaag gctcctcctt caaggtcccg tggttcgggc agctcatgaa 1045861 ggggcctcag ctgatcgccc atcttgctca aattcataca tggtttgaag cgtatcgcat 1045921 tgatattgac gagaggtagg ttcaatacaa atgtgattaa aagccagaga tgtatagatt 1045981 taaataagaa ggatagatga gcagggaaat atatgctcta tctatccttt tttgtacaac 1046041 agcactatcg aattgccccc gcattccttc aataagaatg aataggtttt aatgttctgc 1046101 cgataaaact agctgatacc gggcttaact ttaattccct agcccataca gaaagttgac 1046161 caatatggtg aatttcgtga gcgatgatat ggtgtaatat ttcatctcgc gtatataaaa 1046221 cacctgtctc ccaaggaacg cttacaagtt catcttttat ttgatctgaa tgtgtttgta 1046281 aaacatcaat tatttcagtt cggaatgtat ttgagagaga tttcacttta ttgagtgttt 1046341 gataatcagc gaactgaaca gcgatatctt cttttccttg gatagcacga atccaactat 1046401 attccacatc aataatatga aaaagggtat ataaaatatt ctctactccg ccaagacgat 1046461 ttttaagtaa ttcttcagtg gttagttgat gacaccaagt aaaccattga tctctaacct 1046521 gccagttata ttcaaaaaat ttcatcacta aactcactcc aatactatca tgtatcataa 1046581 caattagccc ttttttccgt gattcctcta ttaatgaagt gatgattgag aaatgtttac 1046641 attctacctg ttgtatggca ttaaaaataa taatgcatat ctcgtcgatg atgctgtgcg 1046701 tcttgttact tttacaaagt aagaatcggc attttcttca tatacaatta ggaaaaaaca 1046761 tactagactt gaagaagcag tgatacatag gagtgagaaa atgaaagaga taaaagaagc 1046821 ttaccagcaa tgcggacaga ttgttggcga atacgcgcca gcctgtttca aagcattatc 1046881 atatctcccg ctaaagcaaa gacaagcctc ttgggcagta ttgtcgtttt gccacacggc 1046941 ggccagtgca gacgaaaagg tattgcccgc atttgaagct aaagctgatc atgtttacca 1047001 aaggacaaat aacggtaaac aacatctatg gaaggctttt gatcatgcgt atcggacctt 1047061 tacattggaa agcgaacctt ttcgggagtt tattgccgca caaaaagaag acgccaagcc 1047121 gtatgatgac cttgatgaac tgctcatgta cgcatatcgg acgggcggtg ctgccggatt 1047181 gatgctgctg ccgatactga cacgccgaaa acaagatcag ctcaaacaag cagccgtctc 1047241 tctcggcttg gccatacagc tggttcgctt cttaagtgat cttggcacag atcagcaaaa 1047301 aaaccgcatt ccccgtcagg taatgcagca attcggctat acagaggctg atctccaaaa 1047361 aggcaccgta aataaagcgt tcacaatgac gtgggagtat atcgcttttg aagcagaagc 1047421 ctaccttgaa gagtgtcagg atgccttgcc gctatttccg cagtattctc aaaaaacggt 1047481 gaaagccgct cttcatttgc accgggctgt tttagaaaaa atccgggcga agcagcacga 1047541 tgtatttcaa tatcacttcg ctctcacaga gaccgaagtg aagcagattc tgtctgatat 1047601 ctaaaaaaca cccggccttg attgagccgg gtgttacgcc ataccttttt gaatccagat 1047661 acgtgagcgc catcttctgt acattaagat tccccggacc cattcatccg cgataaaaga 1047721 aatccaaatg ccggcaagac cgaaaccgag gtggatgccg aaaagataag caagcgggag 1047781 gccaatgccc cacattgaaa tcattgccat gtaaaccggg aatttcgcat cccccgcggc 1047841 ccgcagagag ttaatgataa tgacattaaa cgagcggcct ggttcaagga taatggtcat 1047901 ggcaatcaat aggcttgcag ttgctataat gtcagggctt tgtgtgaaga gtccgatcag 1047961 gtcttttgaa aagatcgtca tcaaaacaga ggtagccgca gcaattccga gtgcccaata 1048021 taagctcttc atgcagcgct cataagcggc atcaaattgt ttgccgccga tataacggcc 1048081 gattaagatt tgtgtaccct ggctgatcgc agtgccgaac agcaaaataa acatcgtaat 1048141 attttgcgta tacacttttg ttgtcaacgc ctgcgcgccc atgatggcga taaaatacgt 1048201 gactatcatt tgcgacaggt tgtatgaaag ctgctctccc gcagaaggaa tgccgatttt 1048261 cagcagcttg cgcaaatgct ctttatgcat atgaaagact tttttcagcg acatcttcag 1048321 ctggatgcgt ttgttgacaa tcacaatcat cgcgattaat ccgatgacgc gggcgataga 1048381 tgtggacatg gccacaccgg caacaccgag aacaggaaag ccgaacaaac cgaaaatcac 1048441 aacaaagttt ccggcaatgt ttaaaatgtt catgccgata gtgacaaaca ttgtatcttt 1048501 tgtgtagccg tagcttttta agatcgcgct gaatgtcatg attaaagcct gaataaagga 1048561 cagacctccg acaacttgta aaaagacttt cgcatcaggc atcagtgcgt ctgataatcc 1048621 catcatatga agcagaggga cagccgcgaa aaagacgacg gcgctgatgg ccaggctgat 1048681 gaagaagttg gcgccgattg acacataagc gacttccatg gcttctttct tttgccgtga 1048741 gcctagaaat tgtgaaatga taacggtcgt tcctgttgcg ataaagctga acatcacgat 1048801 aattaaattt aaaatctggt tgctgacgcc gactgctgcc acgctgttat ccgagtattg 1048861 gctgagcatc agtgtatcgg cattacccat aaacatatat aatgagacct caataaagat 1048921 cggccaagta agcgaaaata atgagaacgt tttgtcagcg ggttttttca aagcagttga 1048981 tttgaagaca gcttgtttca tcgtgtctaa cccctttcgt aaataaaatc aacgttttaa 1049041 agtgtacctc catttcctta taataaaaag ggatagaaac gatacttctt gtaaaaatcc 1049101 gacttaaaaa ggaggatgat tcaaatgcct cgcatcctgt ttacagtccc gccttttccg 1049161 gtatttatcg cagctgggga aggggttttt aaaaaaggag aaacccatgt gaaacgtgta 1049221 ttctccgtgt ttgatctgat atatgtcaaa cagggaacgt tatatataac ggaaaatgaa 1049281 acatcgtttt ctgttgaagg cggcgagtac atcttgcttt ctcccggtct tgaacactac 1049341 gggacgaagg gcagtgatga agcaacctcc tactattggc ttcacttcga tgaacatcga 1049401 tatgaattta cggcaaaggg aggcagcaac tggtctgagc ttcagcagga aaaagggagc 1049461 ttcgaagagc tggcccgcta cggattggcc ttgccgagaa aaggcaaggt gcagcgcccg 1049521 cagtttatgg cgcagcagtt tgaaaagctg atcgattact ccgcggaaaa ctctgatttg 1049581 ccgctcagaa agcaaatttt atttgaggag ctgatgctgc atcttcaaaa agaagcgttc 1049641 caaataccgt ctgcgaaaga gcgggtagcc tgggaggcgg cccggtattt acaggagcac 1049701 tataaggaaa agacgacaat caaggatctg tcgctcgccc ttcactatca tcaggattat 1049761 gtgagccgct gcatgcagca ggtgctcggc gtaactccgg cacaatacac gaaccgggtg 1049821 agaatgacgg aagcgaagcg tcttttatcc tctacaaatg ataaaatggg cgttattgcg 1049881 gaaacggtcg gaatggaaga tccgacatac ttttcaaaac tctttaagca gatagaaggc 1049941 atttcaccaa ttgaataccg gaaaattgtc agccggaaag ttcaataacc agacgaggga 1050001 tgaacatgaa aacaacaatt tacgatgtgg caaaggcggc gggtgtttcg atcacaactg 1050061 tgtcccgtgt gataaacaat acggggagaa tcagcgataa aacacggcag aaggtcatga 1050121 atgtcatgaa tgaaatggca tacacgccca atgtccacgc cgcggcgtta acgggaaaac 1050181 gaacgaatat gatcgctctc gtggcgcctg atatttcaaa tccgttttac ggcgaactgg 1050241 ccaaaagcat tgaggaaaga gcggatgagc tcggttttca aatgttgatt tgcagcaccg 1050301 attacgatcc gaaaaaagaa acaaagtatt tttctgtgct gaaacagaaa aaggtggatg 1050361 gcattatttt tgcaacaggg attgaaagcc atgacagtat gtctgctttg gaggaaatcg 1050421 ccagtgaaca aattccgatt gccatgattt ctcaggataa gccgcttctt ccgatggata 1050481 ttgttgtgat agacgacgtt cgtggcggat atgaggctgc caagcatctt ctgtcactcg 1050541 gccacacgaa catcgcctgc attatcggag acgggtcaac gacaggcgaa aaaaatagaa 1050601 tcaaaggctt ccgtcaggcg atggaggaag cgggcgtgcc cattgatgaa tcacttatca 1050661 tccagacgcg gttttccttg gaaagcggca aggaagaagc gggaaaattg ctcgacagaa 1050721 atgctccgac tgctattttt gccttcaacg acgtattggc ttgtgccgcc atacaagctg 1050781 cgagaataag aggcataaaa gtgccggatg atctttctat cattggtttt gataatacga 1050841 tactcgcaga aatggcggct ccgcccctga caaccgtagc ccagccgata aaagagatgg 1050901 ggcggagcgt catcgaactg ctggcagaag caatagaggg aaaacgaaag gcgaaacaaa 1050961 aaatagtgct cccgcctgag cttgtagtca gacattctac atcaccgctc aacacatgag 1051021 cccgctaatg agcgggtttt ttcattatga cagttgaagc caaaaaaaca tattgcgtgt 1051081 aaaccaaagg cggtgtaaaa tataaccatc ttttgagaaa gcgcttgcgc aaaatggcag 1051141 agcggataga accgctgttt ttttagctgt taagagaaaa cgctttctca aagcgagccc 1051201 gaaatgagat aaaggagagg atgggacgtg gaacatcaag taagatgtgc agtattggga 1051261 ttaggaaggc tcggttatta tcatgcgaaa aatctcgtca ccagtgtgcc gggggcaaag 1051321 ctggtttgtg tcggtgatcc gttaaaaggg agagcggagc aggttgccag agaactcggt 1051381 atcgaaaaat ggtcagagga cccgtatgaa gtgttagaag atcccggcat tgatgctgtc 1051441 attatcgtaa cgccgacaag cacacatggt gatatgatca tcaaagcagc cgagaacggc 1051501 aaacagatct ttgttgaaaa accgctgaca ttaagccttg aggaatcaaa agcagcttct 1051561 gaaaaagtta aggagacagg tgtcatctgc caagtcggct ttatgagacg gttcgatccc 1051621 gcatacgcag atgccaaacg gcggatcgac gctggagaaa tcggcaaacc tatctattat 1051681 aaaggcttta cgcgcgacca aggcgcgcct cccgcagaat ttatcaaaca cagcggtgga 1051741 atttttatcg actgttccat ccatgactat gatattgccc gttatttgct aggggcggaa 1051801 atcacttctg tttcaggaca cggcaggatt ctgaacaatc cgtttatgga gcagtatggc 1051861 gatgtggatc aggcgctgac gtatattgaa tttgactcgg gcgcagcggg ggacgtcgag 1051921 gcaagcagaa cctctccata cggacatgac atccgggcgg aggtgatcgg gacagagggc 1051981 agtattttca tagggacatt gagacatcaa catgtgacca tcctatcggc taaagggagc 1052041 agttttgata tcattccaga ctttcaaact cgttttcatg aagcctactg cttggagctt 1052101 cagcatttcg ccgagtgtgt ccggaatgga aaaacaccga ttgtgactga tattgatgcg 1052161 acgatcaatt tagaagtggg tatcgccgca accaattcct ttcgaaacgg catgccggta 1052221 cagctagatg tgaagcgcgc ttatacaggt atgtaaaagc taagtatgtt gcatttgagg 1052281 ctttccgcaa aaaaagcaag ggcattttag cccttgcttt ctcttttctc atataaatag 1052341 tacatataat cagtaggtac gcctgaatgg tccagctgtc tcagcatggc ggttacgttc 1052401 cctctgtggt aagtgccgtg attgacgaca tgcaggatgg tgtctgcata ggttgattcc 1052461 agtgtaccta gtttcggatg ctgcattgtg aaggtctgtt ctaagtccgt ctggcggctg 1052521 aagaaatcat gatactgtga ctccagctcg gcagcgtgct gtttaatcgc tgccatatta 1052581 ccttgcgcgg actgtaattt gcctgcgctg tctataatct cttggtaggc cactcccgaa 1052641 agaacattca gccaaatgta gtcagccctg cacatatgaa gcagcacgtc gctgacagaa 1052701 ggaaatacgc tctttacttc ttgataggca gtttcctccg gcaggttttc gatatgggta 1052761 aatattttct tgtttgccca agaatgatag tcataaaact gttttgcatc agtcatcagc 1052821 atgccccctt ttctaagaaa ttcgtttttt tcatctgttt ctccttcaat tgcaaaagag 1052881 tgacacccca aaatatcctg ccgctgccca cattaccgct gcagagcatt tgtttacgat 1052941 cagcataagc ctgccgctcg tatctatcgt ctgaaacaac cggcccgcta ttgcaaggct 1053001 gatgaaccaa atccaagaca cagcgatgca ggcggccata aagagccatt tctcaagccc 1053061 cgaatattga agagagctcg tgccgatgac gccgatcgtg tccagaatgg catgcgggtt 1053121 taaaagagaa acagcggccg caaacgcagc ttgctttttt ggtgtgaacg tatgtttctc 1053181 attttggctt gtgttcggac ggatgttcca agtcacccag cccatataaa gcaaaaataa 1053241 aaatccgccg gccatcatga ctgtctcaaa cacaggcagc tcctgcacaa tgacagacac 1053301 gcccgcaacg gctaatacaa ttaacaaggt atcgcagact gaagcactga tgacagctgg 1053361 gagagcccgc caaatatgct tttgcaacgc gccttgctga aaaataaaca cattctgcac 1053421 tcccagcggc aaaattaagc caaacgcgag cacaattccg tgaatgattg cattcatgct 1053481 gaaaaagctc ctttcacatt ttttttcaat cataagagag attgtcacta aagtctccag 1053541 ccatttggtt gggttaggaa ccagccaaat gtataatgtg taaaaaaggg gggcatgacc 1053601 ttgtcgcaat ggcagccaag ccgaaagtcg gatgttccgc tgcatcggca gatcgaacaa 1053661 tatatgaaag acaagattct tcacggagag tgggctgtag ggacgaaaat cccctcacag 1053721 agaacgctgg ccgacatgtt tcaagtcaac cgcagcacag tcacagcagc catagatgaa 1053781 ctcacgtctc aaggcttgtt agagggaaga aaaggcggcg gtacgaaggt tgtaaacagt 1053841 acttggagcg tgctgacggc tgagcctccg cttgattgga gcgattacgt ccgttcgggc 1053901 attcatcgcg ccaattcttc catcattcaa gctattaatc agaacgaacc aagagcggat 1053961 atcatcagat taggaactgg agaactttca ccggatcttg tgcctgctga cacaattgga 1054021 cggatgtttc agcaaatcaa tccgggcgtc ctgtctttag gatatgagca gccgaaagga 1054081 aaccgtcagc tgcgggaggc agtggccgac catttaaaag gaaagaagat ccatgtgtca 1054141 ccgtctgcaa ttttaattgt gtccggtgca cttcaggcac ttcagctcat ctcaattgga 1054201 cttttaaaac gagattctgt cattttgacg gagaagccgt cctaccttca atccttgcat 1054261 gtatttcaat cagctgggat gcggcttcgc ggcttgccga tggatgatga aggggtcaaa 1054321 gcggggcttg tttcttctaa tcgaaaacaa tatggaggac agctgcttta cacgattccg 1054381 tcgtttcata atccgacagg cacagtcatg tcagagcagc gaaggaaaga gatcatcagc 1054441 ctgtcaaaaa aagagcagat gcccatcatt gaggatgatg cgtacggtga tttatggttt 1054501 gaagaaaaac cgccgcagcc gttgaaagca atggatcatg agggcaatat tctgtatctg 1054561 ggcgcgtttt caaaaacggt tagccccggt ctgcgaatcg gctggcttgc cggtccggag 1054621 ccggttattg aaaggctggc ggacattaaa atgcagacag actacggatc aagcggcctg 1054681 tcccagtggg cggctgccga gtggctgtca cagggatatt atgaagagca tctgacttgg 1054741 gtacgcagga agcttaaaga aaggagagac gccgccgttc attttctcga gcggtatgcc 1054801 ggggacattg ccacgtggcg gattcccgca ggcggctttt atatttgggt gacatttcac 1054861 aaaaacctgc ctgtcagccg tttcttttat gaattgctga aacggcaggt gcttgtgaat 1054921 cccggctata tttatgacgg tgaagaccga aacagcatca ggctgtcata ttcctatgca 1054981 tctcttggag atttggaaac tggcattaaa gcggcagctg aaacagcacg ccgcctgatg 1055041 atgtcctagg ctttggttat acgatgacag ctcccagtgc cctggcgaag gcaatcgcgt 1055101 gctcaggtgc gattttgcag cctttcaatt tgtcgaggga gacatgaagc tgttcaaaac 1055161 ggcacgtgct gatgtccatg ttttgaaggg acgtgccggt aaagctggcg ccttccaatt 1055221 cgcatccgtc aaagtgtgtc tgctggagca ccgtatcgct gcattcactt tgcataagag 1055281 cacagtgatc aaatcgaact tgtttcatat ttgagtacga aaatgagctg aaatgtccgt 1055341 ggcattcctc gaatgaaaca ttccgcagcg ttgcttccgc cacattcatt ccaaccattt 1055401 ttgactgctt aactgaagtt ctgtgaatga cagccccgct gaaatcggcg tttgataaat 1055461 cgcatttttc aaagatcaca tcggtcagtt caatatgccg aaaagacaca tcgataaaga 1055521 cgacatttct gaataccgtt ttttcaacac atagtctttc gatatcttcg ccgcagatgg 1055581 tgcaatcttc aaacaaatgc atgctgatta catcatcctg tgtcacggca tcatgaaaat 1055641 ctgcggtttg caggttttcc ggtatgttcg gtttttgaat tgcgatttta ttcatgtgat 1055701 gacatccttt gctgcccgaa aaacagaggc ttccgggttc aatttaatag atcgttaagg 1055761 aaattgatac atatagtaaa tcgtgaagag ccttttcttg gtacagcagc ccgcttgttt 1055821 tgtaagcata aatggaaagc ttcctatacg tcaaggcgtt tacaggccga aaaagccaaa 1055881 gggaacagga ggaatgcgga atggggcatt acatcaaaac cgaggagcat gtgacactgt 1055941 ttgtagagga tatcggacat ggaaggccga tcatcttttt gcacgggtgg ccgttgaatc 1056001 ataagatgtt tgaatatcaa atgaatgagc ttccgaaaag gggatttcgt tttatcggcg 1056061 ttgatttgcg gggatatggg caatctgacc gcccttggga aggctacgat tatgacacga 1056121 tggccgatga tgtgaaagca gtcatttata cgctgcagct tgagaatgcg attcttgccg 1056181 gtttttcaat gggcggcgca attgcaatcc gttatatggc aaggcatgaa ggagccgatg 1056241 ttgataagct gattttactg tctgcggcgg cccccgcgtt tacaaaacgc ccgggttatc 1056301 cgtacgggat gaggaagcag gatattgacg atatgattga attgttcaaa gctgatcggc 1056361 ccaaaacact ggctgattta gggaaacagt tttttgagaa aaaagtgtct ccagagctta 1056421 ggcagtggtt tctcaatctg atgctggagg cttcctccta cgggacgatc cactcgggca 1056481 tcgcattaag agacgaagat ctcagaaagg aacttgctgc aatcaaggtg ccgacgctga 1056541 tcctgcacgg gagaaaggat agaattgcgc cgtttgattt tgcgaaagaa ttgaagcgcg 1056601 gcatcaaaca gtcggaattg gttccgtttg caaacagcgg gcacggagca ttttatgagg 1056661 aaaaagagaa gatcaacagt ttgattgcgc agttctccaa ctcataagaa aaaacccgac 1056721 attgatcggg ttttttatat aattcctctg ttttgcagtg cgttaatgat gagatcagct 1056781 ccatcggaaa tagaggtctg gtcagactca atgatgaaat cgggtgaaag cggcgcttca 1056841 tacggagaat cgatcccggt gaaatgtttg atctctccgt ttcgcgcttt tttataaagc 1056901 ccttttggat cgcgctgttc acaaacatgc agcgggcact tcacataaat ttcgaagaac 1056961 tcacctttag gaaagagcgc tctaaccatg tcccgatcct ctctgaatgg agaaataaaa 1057021 gccgttaaaa tcatttgccc gctgtcgaca aacagcttcg ccacttctcc gatccggcgg 1057081 atgttttcaa tcctgtcacc agtctgaaat ccaagatctt tgtttaagcc gtggcggata 1057141 ttatcaccgt caagcacgta gctctgaatg cccttgcggt aaagcttttc atcgacagca 1057201 ttggccagca ccgattttcc ggagccggac aaacctgtaa accaaaggac gcagcttttg 1057261 tgtccgttta aggactgtct gtcagacttt gagatggcag cgggatgcca aatgatgttc 1057321 ggattgtgtg tcattgcaat tccccgctgt tttgcttgat ggcaacaggc tgttggtgaa 1057381 gtcccttgat cagcacggct gcgacctcag gccggctgaa ttctttaggc ggctttttgc 1057441 cttggcggag aagctctctc acttttgtgc ctgataagtg gatgtggtct ctcgggctgt 1057501 gcggacatgt tttggaggtg cccatgtttc cgcattttcg gcaataaaag ctgtgctcaa 1057561 aaaacagcgg cttgatgccc agctcttcct ctgtgaatga ttgaaaaata ttttgggcgt 1057621 cgtatgttcc atagtagctg ccgacacccg cgtgatcacg gcctacaata aaatgggtac 1057681 agccgtaatt ttttcggacg agcgcatgga aaatcgcttc ccgcggacct gcataacgca 1057741 tggcggcagg gaaaaccgat aacatgacac gatcctttgg ataatagtga ttaagcaaag 1057801 cctggtagct ctccattctg atatcgctgg ggatatcgtc tgactttgtt tctccgacaa 1057861 gtgggtgaag cagcagaccg tcgaccgttt ctaacgctgt tttttgaatg tattcatgcg 1057921 ctctgtgaac agggttcctg gtttgaaagc cgacaatcgt cttccagccg agtttttgaa 1057981 aggccgctct tgtttcagcg ggcgttgcat aaaactgttc gaaagatttg tcaggcaggc 1058041 tgctgaccgt gataggccct ccgatatagt aatccgggcg cgccagcaat ttttttacgc 1058101 ctgggtgggc aggatcgttt gttttaaaaa cagacagtgc ttcttgtgtt ttatcaggct 1058161 ggtatatatc ggtgactgtg atcatgccgt aggtaacacc gtctttcaca agcttgacgt 1058221 gatctccggc agacagctgt cttgctgttt tttctccgac aggcagcgta atcggcaggc 1058281 tccacggcaa gccgtttgcc agcctcatct ctttcacaac ggaatgataa tctttttctc 1058341 ccaaaaaacc tgttaacggg ctgtagccgc cgatcgcaat aagctccaga tcactcagtg 1058401 caagctgatc cagctctgct tggcacgcgc acccttcaaa atggcatgcg ggatcacagc 1058461 ggttgattaa tacccctccg tggggttcgt ttccattcaa cgtgttcaac ctccatttat 1058521 acgtttcctt gttttctttt ctgcacttaa tgaaagtttg acatcagcgc cttaacatca 1058581 tttcgattct cacatcaaga acctgccatc cgctattctt gatgcaggcc gcattctgtt 1058641 ttctcccgtc cggcccatct tccagccctc tcatcgttcg ggtccgggga aggcagtgta 1058701 cacatttcac agcctatgct cggataatgt tgatcgtgca gtttgttata aggcaaattg 1058761 tgcaggcgga tgtacgtcca aacgtcatcc catgtccagt ggataagcgg gcaaattttg 1058821 atgagctcaa acttctggtc caggtttacg tattgaatat gctttctcgt tggtgactga 1058881 tcccggcgca gtcctgaaat ccaagctgtc atgccggaca ggtgcttttt gagcggttcg 1058941 attttccgca attggcagca gaggttcggg ttatgcttcc acagctctcc gccgtacttc 1059001 gtcccctgtt ctgttaagct cagctcgggt tcgagcatct ggattgcaaa tcccggatat 1059061 cgttctttga cggtctcgat cagctcatat gtttcctgaa aatgaagccc ggtatccaaa 1059121 aagatgatgt gtgcgttttt gttgattttt gatattaagt cgagaagcac cattccttct 1059181 gcgccaaagc tgcaggcgta cacaatcttt tctccgtacg ttcggtaagc ccatttcaac 1059241 acatcgagct catcgatcaa ttgatccgtt atctgtttgg acagcatgtc gttccaagtg 1059301 tcatatgtga tggtttcgtt caatgttttc cccccgtttg catctgcttt ttttatctat 1059361 tgatcgagtt ataggcagac tattcatttt ttgcataaag gttcaggttt taggtgccgc 1059421 gcccgcctaa aatgaggtgc ggaaccatta agagcccggc tgaatatgct ttttagcaaa 1059481 atggttttat gcccaaggag aggtagtatg ccgattgcca tttatcaggg gcatcatcat 1059541 tcgcttgccc cggcggacat taacatcgtc attgatgtca tcagagcctt tacggtcgcc 1059601 cattatgcgt ttatcggcgg ggcgaaagag attttgttgg tccggacagc tgatgaagcc 1059661 tttgcgctga aagacaccta tccggattat gttttgacgg gagaggaaaa gggggtcggt 1059721 atcagcggat ttgatttaga taattctcca aaacgtatgg ctgggcagaa tatgacggat 1059781 aaaagcctga tccagaaaac aacaaacggc gtcacagcag cattgggggc gctgaacgca 1059841 aagcatctgt tcgtaactgg attttccaat gccaaaacaa cggcacagca tgtgaaaaag 1059901 ctcgtcgcaa acgattgtgt cataaacata gtggcttccc atccatccgg tgatgacgat 1059961 atggcatgtg cggagtatat caaaggcatc attgaaggga caaatgtggt aacggctgcg 1060021 gaggcgattg aaagaataaa aggctcttct gttgcggaga agttttttga ctgccgccag 1060081 ccattgtttg attcggaaga catcgtttac tgtacaaaag aactgacggg cgatttcgtg 1060141 atgaaagtga aacaagatgg agaagttcca acgatagaga gggtcataat atgaatgatt 1060201 tttcactaga attgccagtg agaacaaaca agccgagaga aaccgggcag tccattttaa 1060261 ttgataacgg ctatcccttg caatttttca aagatgcgat agccggagcg tccgactata 1060321 ttgattttgt gaaattcggc tggggcacat cattacttac gaaagatctt gaagaaaaaa 1060381 tcagcacact gaaagaacat gacattacat ttttctttgg cggcacactg tttgaaaagt 1060441 acgtaagcca gaaaaaagtg aatgaatttc atcggtactg cacctatttc ggctgtgaat 1060501 atattgagat ttcaaacggt acgctcccga tgacaaataa agagaaagcg gcttacattg 1060561 ccgatttttc tgatgaattt cttgtgctca gtgaggtggg cagcaaggat gcggaattag 1060621 caagccggca aagctctgag gaatggcttg aatatatcgt tgaggatatg gaagcgggcg 1060681 cggaaaaagt gattacagaa gccagagaaa gcggaacggg agggatctgt tccagcagcg 1060741 gcgatgtcag gtttcaaatt gttgacgaca tcatttcctc ggatattgat atcaacaggc 1060801 tgatttttga agcgcctaac aaaacgcttc agcaagggtt tattcaaaaa atcgggccga 1060861 atgtgaatct tgccaatatt ccatttcatg atgccatcgc gttggaaacg ctgcgtttag 1060921 ggctaagatc cgataccttt tttctgtaaa atagcggctg cggggctctc gtcgtgaaga 1060981 gagcctctgc ctattatttt ttatggcggt acataggcgt gagataggga agtgaggtca 1061041 ggcggatgtt gtagatgaag tcgatgactc ttgtcgatat cacctggcat atgagggctt 1061101 gaatgacgat gccccagtca ataatagacg cggtgaccat aaaaatgatg caattcatga 1061161 tgagcaggat cgttccagga ttcccgccgc ggtagataga aatcatcaga gcaagggctc 1061221 cgaatcctcc gttcgaaatt ttatatttgt ataaaagtcc gattccgagt cccaataaca 1061281 ctgcgccgct tgccagatca agccacaggt tagatgtgat atcaggaaaa actgcatcaa 1061341 agatcaatac cgagacagag gtgacggtga tagaagcgag ggtgccggtg aatgttctca 1061401 tctccagcca ttttaaagcg gtaaaaagca ttgatacatt cacagcccac actgaaaatc 1061461 cgtgggggat ttgaaacaga taatgcaata gcaccgcaat acctgctgca ccgcctgtcg 1061521 gaatatcatg cggaaataaa aacaaggaca tgccgagtcc ttgtagtacg ccgcctacga 1061581 caatcataaa cgtaagtttt gctttcatca gcagttcagc cattaagtca tttgctcctt 1061641 tatgaaaaga cttgtccgct gttttcattt tatgaggctg tccattattt atgtctcaaa 1061701 ataaagaaat ggcccagctt aataggctga gccatcccac ttgtagcgat tgacgatctc 1061761 catattgatc tctgtgccaa tgccttttcc tttcgggatg tggaccattc cttttgaagg 1061821 ctgcaggctg acgagatctg taaaaggatt ctccatgacg tcccactcga tcggttcaat 1061881 gtgatcgttc ttcattttag accatggggg cagacaggct tgtgcaaata aagcatagag 1061941 ccgtgagagc gatccgtcat atgcatgggc ggatgctctg acgccgaaat aacgcgcgag 1062001 ctggaggcag tcccgaaact catcaattcc gttgacatgc atgacatcgg gctgaatgat 1062061 atccaaacag cgctgtgaaa ggagaggcac atattgcgcc gggcctttca tgttttctcc 1062121 gccggcaaca ggaacagaca aacggcttcg aagcatagcg taatcctgcg gctgatcaaa 1062181 gggcaaaggc tcctcaagcc agccaatgtt cgtccattcg gagaaatagc gctcccattt 1062241 aaaagccgca gcggcatcgt agctttggtt tgcgtccaga atcatcgtaa tggagctgcc 1062301 tgctgtatgc tgcagcgcat tgatgtgccg gacatcctcc ttgaatgaag tcccgccaat 1062361 tttgactttg atttgctcaa aacctttttt caactgggct tcaacattgg agactgagcg 1062421 gctgatccat tgcggggagt ctgagtacga ttgaaaagac gcgtacacag gaatctcctc 1062481 tctgtatcgc ccgccccata attcgcaaac cgaacaatcc gcagctttgg ctgcaatctc 1062541 tgtcagcgcc atgcttacag cggaggccgc ccgctggtgc catttttgaa tcgtgcgcac 1062601 taatgacagg cggctgccag cctgttttcc taatagaaat gggatgatcc gcttcgtaaa 1062661 accgacatgg agagcaggga gccaatcaac gcattctccc cagccgtcta tcccgctttc 1062721 ggtgataatc ctgatgagat aacaagtccg atatcgttta aacccattgg catctccgta 1062781 tggcttttct aatcgatgaa atagcggaaa ggtttcaatc cgtacaattt tcacactggg 1062841 tgctaccttt cctcagcggg ctggagccga ttgccagcca ttttagggtc ttctttttct 1062901 tttgtttctt cattgttttg cttcacatgg atgagcatca tcacaagaat cccgacaacg 1062961 agagtcaatc ccgcgatgct taaaaacatg ccgggtctgg accattgcat caggcggccg 1063021 aaaatcggag gaccgatcgc tacccctaag aaacgtacag agccgtacag cgaggtgaca 1063081 aatccccgtc tttctttgcc gacagccccg gtaatgaaac tgttcacaca aggaaggaca 1063141 agacctgagc ctatactgct cagtacaaga acactgataa aaaggacaag attttcaatg 1063201 aatgacagtg ccgcgtagga tacggtcatg aacgccaatc caagtacgat cagctttttc 1063261 attaacgatt gcttttgccc gattttgctt cctgttgtat aggacgtcac acacataacc 1063321 aaaagcggga tcgctaaaat taagcctttt ttcacgccgt cggtgtcgta tgttttttca 1063381 agaacatctg agagataaaa caggatgccg aataaagtaa acaaacaggt cgcaccggct 1063441 aaataagcgg taaacagcca tctgccttca tgtttaaaga cacttaacag cccttttgca 1063501 tattgtccga ttggtggcgg ttctttttcc tttttctttt ctttaataaa aatccaagtc 1063561 agtacgatcg aaatgataca aaacacagga aaggcaaaaa acgcgccata ccagacaagc 1063621 agggcgatca gcgagccaat gatcggcgat agcactttcc ccatgccgtt tgaagcttca 1063681 acaaggccga gcaccttgct ctcctgggcg cctttaaaca gatctcccgt cagtgccatg 1063741 gcaattgggc cggttccggc tgccccgatt ccctgtaacg ctcgtcctgc catgacccaa 1063801 ggataggcat tgtcaaaaaa acctgccgca aacccggcta acaaaccgcc ggcaccatac 1063861 aaaattaagc agggaataat gatgactttc cttgagaatc ggtctgcgag ataaccgaca 1063921 atcggaatcg caaatgctgc aatcaaggaa aatactgtga tcacgagact gacttgaaat 1063981 tgtgataaat gaagttcaga tttcattttt ggcaaaatcg gaataagcat cgagtttcct 1064041 agggttaata ttaaagggat tgaaccgatt gccacaatcg tcattccgtt attttgtttt 1064101 gatgattcca tctcagagca cactcctttt cttctgctta gaatgtccct gatggcttcg 1064161 tttattcagc gatcagacag caaaaaaccg aacagaagat acctgttcgg gaaaaaagag 1064221 ggttaaccga gagcctgtga aatcaaagca tataagtgtc cattttgaat aggcgctttt 1064281 ttctgataga acaaaatcgg aggttcatca tctttatgaa atcccatttc tatcaggctg 1064341 tcatgcagag acgtgtgttc actcggtata tcgattcgca tcggcccttg tttgccggcc 1064401 gccagccttg taattatctg tgctgcaaca tctgatgatg gagcgatgat agggccgaat 1064461 ttcaaattgg ccggtgtctg tacagaaagt ccgtagccaa tgagctgtcc gtcctgattt 1064521 ctggcgatga tacattcgca tgaagcagaa ataagctgct gcaaaaggtt tgatcgatct 1064581 ccgccaaagg cagccagatc cgccgcggtt aagtcgtgaa agtcttgttc tctaaaggat 1064641 gtcagttcag catcaagctt ttttgtataa ggttgaaaac tgtgacagct gtactttcgc 1064701 actgaacctg ccgtatgaaa acctgctttt tcataaagcg gcaaaccttc ttttgtggcg 1064761 caaagcctga tggcggtgtt ttcatccgtt tgggtaatac aggcgtttac catacgccgg 1064821 ccaagaccga gccgttgata ttccttgtca acgataacaa ggccgataga agtaagacgg 1064881 ccaaacaaaa acaagccgat gcaggaaata atatcaccgc tgacattttg ataaccgaaa 1064941 aagcgtccct gctgaacaag cagtttcagc tcttgttcgc cataatccgg ccacccggct 1065001 tgcccgcaaa gccgcaataa gccggaaacg tgttcttcat gaagcttaat cagttcatct 1065061 actacgtcca taagatcacc tgcttgttct aagtgttttg tacatgacaa tatgattgcc 1065121 aatgccggga atgtcaaatg gttcgccaag ttccttccag ccaagcttgg catagtagcc 1065181 cttgacatgg tgtcttgcgt tgcaccatac cgcctgaacg ccgctctccg ccagtttgtg 1065241 ctccgcgtgt ttgatcagcg tgcttccagc tttttgatcg cgatatccct cgagcgttgc 1065301 catgcctctc agccgatacg cagaggcttc cgttaataaa ggctgacttt gcggggaaaa 1065361 agaagcgatg ctgatcagcg ttccatcata aaacacgccg agatgaaagg agccttctgc 1065421 gtgatcctct ttatatttgc attgttcgat ggattgatgg ggacgcagaa tgcgatgccg 1065481 gatttcatat gtatcttcca cggaaatggt tttgacttcg agcataatgt tcctcctcat 1065541 gattgttttt ctatatcgta acacgaatct cgttgaaaaa gactgcccga ttcgatcagg 1065601 cagtcttttg gaaattaatg caaaaagata ttttggcgct gctcatcttt ttgctgaata 1065661 tatgatgtga gctcagcggt taagtcagat ctgaggaaag gcgttatcaa gtagatgccg 1065721 ttaaacagct cgcatgccgt atccagcagg gagcgtgcaa ttgcaaggcc ttccgccttt 1065781 tgcttttctt tatcttcacc ggcatgggcc attttttcgc gaatcgtatc agacagctta 1065841 atgccgggaa tttcattatg gatgaattcg gcattccggc tgcttgtcag cggcatgatg 1065901 ccgatataga tcggcgtctt cagatgtttt gtttcgttat ggatatcgac aagctgctgc 1065961 tcggaataga caggctgaga aacaaaataa tctgcgccgc aatctatttt tttctcaagc 1066021 cgttttaccg ctttatccag atggcggacg ttaggattaa atgcggcggc aactgagaaa 1066081 ttcgttttct tgccgagcgg ttttccagac agagacagac cttcattgaa ttgtttgatc 1066141 agcctgatta aatcaaaaga tgttaaatca tatacagacg tcgccccagg aaaatccccg 1066201 attttagaag ggtcacctgt aatagcaagc acgtcattca gccctaacgt atcaaggccc 1066261 attaaatgtg actgtaagcc gataatgtta cggtcacggc acgtaatatg gacaagggaa 1066321 cgcatatcga gctgctgctt gacaagggcg ccgcaggcaa cattgctgat ccgcggggtc 1066381 gccaaagaat tgtcggcgag tgtcagggca tcgattcccg cttcttttaa ttcagcagca 1066441 gcggacagaa atttgtcaaa gcttagtttt ttcggcgggt ccagctctac gataatagag 1066501 cgttttttcg ctgcgatctc atccaggccg ggctcggttc gctcgtgatg aacagaaatg 1066561 aattctttcg cccgggtttt gacttctttt tccgtaatcg gagccagccc gccaaccgct 1066621 tccgccatcg ccctgatgtg attcggcgtt gtgccgcagc agccgccgat aatccgcgca 1066681 ccttgcttac ggaattctga cgcgctgttt tgaaaatacg tgtcgtctgt ttcatagacg 1066741 agccgtccct cttcaagcga aggaagactg ctgttcggat aaacggataa gaatacgtca 1066801 tcaaaaatcg gcacttcgct tagcgcttca atcatgtgat aagggccgag gcggcagtta 1066861 atgccgacaa tatcagctcc gagatccgca atcgagcgca atgcgtcaga aagcggcgtt 1066921 ccgtcctgca atacgccttg ctcgtgcatg gagacattga gcataatcgg aagatcagtc 1066981 tctttgcgcg cgattttcag cacttcacgg gcttcttcca aatcataata tgtttctaac 1067041 agcaagccat ccggctcttc atgcagcagc agatacagct gctcgcggaa gctgcgctta 1067101 atttcgtcaa gactgtatgc gtttttatta aatgtgcgta tgccgcccat cgttccaagc 1067161 acgtatgcat cgcctgctga agcccgcgcg atctttacgg cctcctgatt catttttttg 1067221 atgtcatcct caagcccgtg tctggataat ttaatatagt tggctccgta cgtattcgtt 1067281 tgaataatgt tggctcccgc ttcaacgtac gctttatgta tgcgctgaat ttcctccggc 1067341 tttgaaatat tgagctcctc aaaacacctg tcaatgccat aggagtagag gagcgtcccc 1067401 atggcgccgt caccgattaa cacctgtctt tgcaaatctt ctaaaagtcc cattgtctgc 1067461 ctcctttatt cacatcagca aggaaaaaag agaaataaaa aaagtcctct taagaagaag 1067521 actttgtcag tgattttgtc tcttcttatc ttccaagctg ttcgagcttg ctggatttag 1067581 caccttggtc atggctgatc gccattacac cggttgctga agcttcgtcg ggccagtccc 1067641 tctgcttctc ttgataagaa cggatatgaa attttcgtgt caggaagtgc caaaagatat 1067701 ctggcgtttt tccctttctc caaatttacc gaaaataaag acaataatca ataggaatca 1067761 gaaaatttat ctgaaattta taaattgaac gtcaattggc agatctgctc cccgtacagc 1067821 tgagataatc tgctgcaggt catctttgtt ttttccggtg acacgcactt gatcatcctg 1067881 cacctgagac tttactttca gtccggagtt tttgatgatc gtattgattt tttttgcgtt 1067941 gtccttgtca atgccttgaa caagctttgc acgctggcgc accgttccgc ctgacgcgtt 1068001 ttcaaccttg ccgtaatcaa tgttttttgt cggtacgttt cgtttaatca atttgctgac 1068061 cagcacatct ttcagctggc ttaatttgaa ttcgtcatcg gaaacgagga ccagctcctc 1068121 tttatctaaa gaaatgtcgc ttttgctgcc tttaaagtca tatcgggtac tgatttcctt 1068181 cagtgcgatt tggattgcgt tttgcacttc aggcaattcc accttggata caatatcaaa 1068241 tgaactttct tttgccatat gaaaacctcc ataacattta acttatgtgt tgattatagt 1068301 agaataaaga gaaacttcca acagaacaaa gaatcaattt gtgatgattg gaaaaaatgt 1068361 taacaaaatc cgcagagaat aagcggaaca ggaaggacga tagcatgaga ccagggcagc 1068421 aattaacctt gagtatagat caccaaaccg acttcggtta ctttttaacc gatggggaag 1068481 atacgattct cttacataac agtgaaatga ctgaggatat cgaggacaga gacgaagtag 1068541 aagtctttat atacgtagac cagcaggaaa ggcttgcggc cacgatgaaa attccgatca 1068601 tcagcgcgga tgaatatggc tgggttgaag tggtggataa agtggaagat atgggcgttt 1068661 tcgttgatgt cggtttatcg aaggacgcac tagtcgcaac tgagcatttg ccgccgtacg 1068721 aagatgtctg gccgcaaaaa ggggacaaac tttactgtat gctgaaggtg acgaaccggg 1068781 ggcgcatgtt tgcgaaacca gcgccggaag atatcatcag cgaactgttt accgacgctt 1068841 cagaagatct gatgaataaa gagctgacag gtacggtgta caggctgatc gcatcgggtt 1068901 cattcgtgat cacggatgac ggtatccgct gttttattca cccgtcagaa agaaaagagg 1068961 agccaagact gggttcaaga gtcacaggcc gggtgattca agtgaaagaa gacggttcag 1069021 tcaacttgtc gctgcttccg agaaaacagg atgcaatgtc agttgatgct gagtgcattc 1069081 taacgtatat gagaatgaga aacggtgcca tgccgtacag tgacaaaagc cagcctgacg 1069141 atatcagaga acgttttaat atgagcaaag ccgcctttaa acgcgcgctg ggccatttga 1069201 tgaaaaacgg aaaagtgtat caggaaaatg gatggacata cgagaaaaaa tagcatgaaa 1069261 acggctcgcc tgcagcagac tgcggagcga gccgtttttt tatgtctagt ttaattcatc 1069321 aaccagcggc caactatatc atattaattt gccaaaatcg tgttcaaata tttgttttaa 1069381 gggaaaacat aataaagaag aaagagcgga ggaacatgcc atggtactag atcaaacaaa 1069441 aaaattactc atcgtcatca tcggcgcttt actcaatgct gccgggctga acttattttt 1069501 gatacctgca gatgtatatg ccagcggatt tacaggtgtt gcccagcttt tatcaagcgt 1069561 cgttgatcaa tatgccccct tttacatatc gacgggaacg ctcttgttcc tcttaaacat 1069621 tccggtcggt attttaggat ggctgaaggt cggcaaatcg tttacagtgt acagcatttt 1069681 aagtgtcgca ctcactactc tgtttatggg gatcctgccg gaaacaagcc tgtcacatga 1069741 cattttgctg aacgcggtgt tcggcggcgt catttccgca gtcggtatcg gcttaacatt 1069801 aaaatacgga gcttcgacag gcgggcttga tatcgtcgcc atggtacttg caaagtggaa 1069861 ggataaaccc gtcggcacgt atttcttcat tctgaacggg attatcatct tgacggcagg 1069921 attattgcaa ggttgggaga aagcattata taccctggtt acactatatg tgacaacgag 1069981 ggtgatcgac gccattcaca ctcgccacat gaagcttacg gcaatgattg tgacgaaaaa 1070041 agcggacgaa atcaaggaag ccatttacgg aaaaatggtg cgcggcatca caactgttcc 1070101 ggcaaaagga gcatttacga acgaacagaa agaaatgatg attatcgtca tcacgaggta 1070161 tgaactgtac gatttagaaa agatcgtcaa agaagttgat ccaaaagcat ttacgaacat 1070221 cgttcaaacg acagggattt ttggtttctt tagaaaagac tgacgaaagc aggtggaagt 1070281 cgtgaaacgg ctgcttgtga tgctcctccc cgtgctgctt ttgataggct gcgggaaaga 1070341 tgagcagaca gaacccgata aggaggtatc aggcggaatg gagaatcaag aggttgtttt 1070401 atctattgac gcaattcagg agcctgaaca aatcaagttt aacatgtcgc tgaagaacca 1070461 aagcgaacgt gctattgagt ttcaattcag cacagggcaa aaatttgaac ttgtcgtgta 1070521 tgattctgag cacaaagaaa gataccgtta ttcgaaagaa aaaatgttta cgcaggcttt 1070581 tcaaaacctg acgcttgaat ctggagaaac atatgatttc tctgatgtgt ggaaggaagt 1070641 ccctgagccc ggaacctatg aggtaaaggt gacatttaag ggcagggcgg aaaatctcaa 1070701 gcaggttcag gctgttcagc agtttgaagt caaataagag gctatggcga gtcgccatag 1070761 ccttttttta ttgcagtttg tccagctgat tttgaaattg atgcaactgt tgacgttccg 1070821 catctgtcga attggcatac gcagaagata cagcattttt ggctctcaga atcgcttgct 1070881 cctgatcgcc ttcctcaaag ccgtttgtca ccatgaccgc ctgttgaaca aatgattttg 1070941 cctgctgaaa cagttcattt ctcatttaat attcatactg cctttcagcc gagtctcgtg 1071001 ccgcggcatg ctggtgagct tcttctaaag tagaccgata tggaaatctt gcggcgtgta 1071061 gcccgatgga gtctttaccc tgctgaataa accttctgga tttgcttcgt ttacccattt 1071121 tgagactgcc cccttccata ctttgacgag atgagtcgtc ttcaatagta tggtggggta 1071181 aagtaaggtt tatgagtggg aaaaattaat acggaccttc tttaaagtga gaaatattct 1071241 ttcaaaaacc ttgccacgcc gtcctcttca tttgtggccg tagttcggtt ggcaatctgc 1071301 ttgaccgcgt caattccatt tcccattgca acgccgcagc ctgcaaattc aagcatttcc 1071361 aaatcgttat cctcatctcc aaaagcaatg atccgctccc tcggcacgcc gtaataatcg 1071421 ctgattttct gcaggccgac cgctttattc atgccgcttt tgataatttc aatgacatgc 1071481 caaggagcgg cccatcttct atggtcgatc acctcggcat gcacatccga taaatatgag 1071541 cgtattgccg gcacatcctc ttcctttgca tgtatgagta cggacgtcac atcttcaccg 1071601 agattttccc gcaagtctcc gaccgttaca tttgttgtgt tcatgttaaa ggcatctatc 1071661 aggtgctcat catggtaatg aaagtatacg tcgtcaatca cttcagcaag cacgttatgt 1071721 acgttgtagc tctcgctgat atccacgagc tgtttgacaa catcaagcgg cagtgacgta 1071781 tgataccgtc cccagctgtc gtcttgcgga tgatggacaa atgctccgtt aaaattgaca 1071841 attggcgttg tcagctccat ctgctggtag tacatggaac ttgaacgata cggacggcct 1071901 gttgagatgc agacataatg cccgtcatct tttaggcgct gtatcgtatg aagggtgttt 1071961 tcagatatgg ttttatcatc ctttaataat gttccatcta aatctaatgc gattaaatag 1072021 ggttttgtct ccatgaaaag ctcctttaac cttagatttt gcttgttttg ccttacttac 1072081 agtgtagctt tttaccatct ttattgtcta catgttacac ttatgattat ggttatccta 1072141 aggaggggca cattgtgata caaattgaga atcaaaccgt ttccggtatt ccgtttttac 1072201 atattgtaaa ggaagagaac aggcaccgcg ctgttcctct cgtgatcttt atacatggtt 1072261 ttacaagcgc gaaggaacac aaccttcata ttgcttatct gcttgcggag aagggtttta 1072321 gagccgttct gccggaggct ttgcaccatg gggaacgggg agaagaaatg gctgttgaag 1072381 agctggcggg gcatttttgg gatatcgtcc tcaacgagat tgaagagatc ggcgtactta 1072441 aaaaccattt tgaaaaagag ggcctgatag acggcggccg catcggtctc gcaggcacgt 1072501 caatgggcgg catcacaacg cttggcgctt tgactgcata tgattggata aaagccggcg 1072561 tcagcctgat gggaagcccg aattacgtgg agctgtttca gcagcagatt gaccatattc 1072621 aatctcaggg cattgaaatc gatgtgccgg aagagaaggt acagcagctg atgaaacgtc 1072681 tcgagttgcg ggatctcagc cttcagccgg agaaactgca acagcgcccg cttttatttt 1072741 ggcacggcgc aaaagataaa gttgtgcctt acgcgccgac ccggaaattt tatgacacga 1072801 ttaaatccca ttacagcgag cagccggaac gcctgcaatt tatcggagat gaaaacgctg 1072861 accataaagt cccgcgggca gctgtgttaa aaacgattga atggtttgaa acgtacttat 1072921 aaagcactaa gttattaaca agagctgaat ttacgttata ctgtagaaaa aaggagtgag 1072981 ggaacgtgga agaagcatta aaagaaaaca tcatgggcgc cctggaacag gttgtcgatc 1073041 ctgagcttgg cgttgatatc gtgaacctcg gcttggtata tgacgttgat atggatgaag 1073101 atggcttgac gcacatcacc atgacgctaa catcaatggg atgcccttta gcgccgatta 1073161 tcgtggatga ggtgaaaaaa gcattagcgg accttcctga agtgaaagac acagaggttc 1073221 acattgtatg gaatccgcct tggactaggg ataaaatgtc cagatacgca aaaattgcgc 1073281 ttggcattca ataaaacaaa aaaggacagc ctgacatgtg aggctgtcct tttttacagc 1073341 tgaaaggagt gaaaggaaat gatgtacctg ctggcagttt tatgcccgcc gcttgctgtt 1073401 ttgttttcgg gaaaaccgtt tcaggccttg ctgaatctca tattgacctg tatcttttgg 1073461 ctgccgggcg cgattcacgc ctgctttatc gtcgccgacc gccgtgccga aaaacgggca 1073521 agaagataat ttggaaaaat gaggacgcag tcatggtata atggtcataa aaacagcagg 1073581 gagagcacta tgaaaaagaa attgcttgca ttcgcgcttt gtactggcgc gtatgcggcc 1073641 ctgtttgcgt actctgtgaa ctcagagcaa aaaacagcca caagcgagat gacggatgtc 1073701 agccgcctga tgcctgtaaa aataaagcag acagtgaaag ggcaggaaga ggaaatgctc 1073761 attgacacag tcaaagaggc aaatcgaaaa aacataaaaa tttcaatcgc cggggcccag 1073821 cactccatgg gcggccatac atattatgag gacggcatcg ttctcgacat gacgggctac 1073881 aacaaaatcc tgtcactcga tcaagagaag aaaaccatca gggtgcaaag cggtgcaacg 1073941 tggaatgata tccagaaata cgtgaatcca tacggactcg cggtaaaagt catgcagtca 1074001 caaaacattt ttacaatcgg cggatctctc agcgcaaatg cacacggacg tgatattcgc 1074061 tacggctcgc taattgatac agtcaaatca ttccggcttt taaaagctga cgggatgatt 1074121 atcactgtca ctccaaaaga tgatttgttt acggcggtca tcggagggta cggccttttt 1074181 ggcgtgattc ttgatgtaac gcttgagctg acagatgatg agctgtatgt catgaagaca 1074241 gaaaaaatga attacagcac atactcagac tatttttcaa agcatgtaaa aggaaatcca 1074301 gatgtccgaa tgcatctggc gcgaatttca acagcgaaaa aaggatttct gaaagacatg 1074361 tatgtcacga attacgtatt ggctaatcat caggatcagc tgtcctcata cagcgaactt 1074421 aaagaagacg agtatacggg agccacaaag tttgcactcg gcttgtcaag acggtatgaa 1074481 tgggggagga attggctgtg ggacacacag caatcctatt tcctgagcca gaacggcaca 1074541 gagatttcac gcaataacgt catgcggtcc gaatcaaagt ttcttgagta tgaaaacaat 1074601 gacaacacag atgttttgca agaatacttt gtgcccgtga aggagtatgg gtcctatatt 1074661 gatgacctga gacaaacgct gtcggacgaa gatctgaacc tgctgaacat tacgatccgc 1074721 tacgtgcaga aaaatgaaaa ggccgacctt tcctatgcga aggacgatat gttttcgctc 1074781 gtactattaa taaacgaggg cttttcaaaa gaagaccagg cagataccgc ccgaatcatc 1074841 aggcgcatga cagacgttgc catcaagcac ggcggcagct attatctgcc ttatatgacc 1074901 taccagacaa aagcgcaaat gagacaggca tatccgaaaa gtgaagcgtt ttttcagaaa 1074961 aaacgaacct atgacccgga tgagcgcttt atgaattact tttatcagag gtataaataa 1075021 tggggaaaaa caaattaaaa tggctgacat tatcacaaag cagcgtgttt ttcgcaagca 1075081 gcttaatctt tccgttttat attctgtttg tgaaaaatat cggctcaagc tacacacagt 1075141 tcggtttttc ctacggattg ttcgggttga gcggagcgct tatttacccg ctcctcggac 1075201 ggctgtctga aaggtttgac agccgttatt ttctgcttct gaactcgtgg gggatggctg 1075261 ttctgctttt atatgtcccg catatcggaa gcgtcgttca agtgtatatc gtccaagtgc 1075321 tgttagggct ctttggagcg atgcaaaagc atggagaaaa agtgctgatc gctaatttta 1075381 cagacagtgg agagcgtgga aagaagatcg ggaattacca tttttggaca gctgtctttt 1075441 cagcagcagc cattatgctc gggggctttc tcgctgactt tttcacagtg caaatgattt 1075501 tttatgcaag ctctattcta tattttttga gtggattgat gatgatgaaa acaggctgac 1075561 gcggtcagcc tgttttttta tgcggctgaa atgcggcacc gcatcaacgt ttttgtgctg 1075621 gagtcgtgct gatttttttt gagcggaatt cccattgaac agaaaattta taaatgaata 1075681 aaaatattaa atatacgatt gaattaattt ttattcatgt tataatgtta aataatttca 1075741 caaagaccaa gagggtgaac ttgttttgaa aataggaatt gtaggtgcta caggatatgg 1075801 aggcaccgaa cttgtcagga ttctttcgca tcatcctcat gcagaggaat gcatacttta 1075861 ttcatccagc ggagaaggga atgtctatag cgagggttat cctcatctta ccggcttagc 1075921 ggatcagcag ctgaagccga ttgatatgaa tacgatcaaa cacgaaatag atatcatgtt 1075981 tctcgctgcg ccgcccggag tatcaagtga attgactcca aagctggcag acgcgggaat 1076041 tacggttatt gatctgtcag gtgatctgag gataaaagaa ccggctgaat atgaaaaatg 1076101 gtataaacgg acagcggcac cgaaggcggt gattcaagag gcggtatacg gtctggcaga 1076161 actgaatcaa ctgcaaattc aacaggcgaa actcattgcc aatccaggct gttttccaac 1076221 agctgttttg cttggcctcg cgccattggc tcaaaagaaa ctgctcgatg aatctttcgt 1076281 tatcgttgac gcgaagaccg gtgtttccgg agcgggaaga aaagcatcca tgggaactca 1076341 tttttctgag ctgaacgaca attttaaaat ttataaagtc aatgaacatc agcacacgcc 1076401 ggaaattgag caggcgctga atgaatggca gccaggtctc gggcccatta cattttcggc 1076461 tcacttggtt ccgatgacaa ggggcatcat ggcgacgatg tataccagat taacctgtga 1076521 cctaaccgca gatgacctgc atgatttata ttcggaattt taccaagatt catattttgt 1076581 gagagtgagg ccaaaaggtc agtacccgca aacgaaagaa gtgtacggca gcaatttctg 1076641 tgatatcgcc gtgaccctcg atgagagaac gaacagagtc acgatcgtct cggtaatcga 1076701 taatttaatg aagggtgccg ccggtcaggc agtgcaaaac tttaatttga tgaatggctg 1076761 gaatgaagaa actggactca ccatcacgcc aatttatcca tagaacggga gagaatcgaa 1076821 ccatgattca gttaagtgaa gatcaaattg taaaagtaac aggtgatgta tcctcgccaa 1076881 aagggtttca ggcaaagggt gtgcattgcg gactgcgcta ctcgaaaaaa gacctcggcg 1076941 tcattatcag cgagacaccg gccgtgagtg cagcagttta tacccaaagc cactttcagg 1077001 ctgctccgat caaagtgaca caagacagct taaagcacgg accgacactg aaagccgtca 1077061 tcgtcaacag cgccattgcc aacgcctgca cgggagaaca gggcttaaag gacgcataca 1077121 caatgcggga gagctttgct tcacagcttg gcattgagcc ggagcttgtc gctgtttcat 1077181 caacgggtgt catcggcgag catttagaca tggaaaaaat ccacgcgggg atcgaactgc 1077241 tgaaagaaac acctgcggga tcaggcgatt ttgaggaagc gattttaaca actgatacgg 1077301 tgatcaagca gacgtgctat gaactggcaa tcggcggcaa aacagtcacg atcggcggag 1077361 cggccaaagg ctctgggatg atacacccga acatggccac gatgctggga tttgtgacaa 1077421 ctgacgcggc aatcgaagaa aaagcgctgc aaaaggcgct tcgggaaatc actgacgttt 1077481 catttaacca aatcacagtt gacggagaaa catccacgaa cgacatggta ttagttatgg 1077541 cgaatggctg cgccgaaaac gagtgcctga cagaagacca tccagactgg ccggtcttta 1077601 aaaaagcgct cttgctcact tgtgaggatc tagctaaaga gattgccaga gacggagaag 1077661 gcgcgacaaa actaattgaa gcccaagtac agggagcgaa aaacaatctt gatgcaaacg 1077721 tcattgccaa aaagattgtc ggctcaaatc ttgtaaaaac ggcagtatac ggaacagatg 1077781 ccaactgggg gcggatcatc ggagccatcg gacactccgc agcacaggtg acggcagaag 1077841 aagtagaggt ttatcttggc ggccaatgcc tgtttaagaa taacgaacct cagccattct 1077901 ctgaatctat cgccaaggaa taccttgaag gagatgaaat caccattgtc atcaagatgg 1077961 ctgaagggga cggaaacggg agagcgtggg gctgtgacct gacctatgac tatatcaaaa 1078021 ttaacgcgag ctatcgcacg taataaaggg gagcgaaatg aagaaaacaa tcgtttttaa 1078081 atgcggggga agcgtcatcc gtgagctgtc ggaggaattt tatcaaaatc tgaaagagct 1078141 gagggcgtca ggctggaagc tggcaatcgt acatggcggg ggaccggaaa tcacaaatat 1078201 gctgaaacgg ttaaatatca agacagagtt ttcgggcgga cagaggaaaa caacgaagcc 1078261 ggtgctggaa gtggcggaaa tggttttatc cggttctgtc aataaatttt tcgttgctga 1078321 gcttgccaaa cacggactgc gagccgcggg catttctggt aaggatggcg gtcttttgga 1078381 ggctgattat ctagatccgg aaacatacgg agaagtggga gaaatcaaaa aagtcgatgc 1078441 gtccatggtg aacgcgctga tggaaaatgg catcatcccc gttattgcgc cgctgtctat 1078501 gacaagcgac tgcaaaacgc tgaatgtaaa tgctgatctg gctgcttcag cagtcgccgg 1078561 agcgcttgaa gccgataagc tgatgttcgt cacggatgtc gatggaatca tgaaggaaaa 1078621 gcagcgtctg gacgtcctga cccctaagga gattcagatg ctgatcaagc aggaagtgat 1078681 cacaggaggg atgatcccga aggtcaattc agccttgtca gctttatcag atcaggtgtc 1078741 tgaagtcatg atcgtaaacg gtaaaggatc attcttcgca gaacaaacct ttcaagggac 1078801 aaaaattgtc aaagcaaagg aggctgtttc atgagcagct tgtttcaaac ctacggccgt 1078861 tgggatattg acatcaaaaa agcaaaggga acgtacgttg aggatcaaaa cggcaaaacg 1078921 taccttgatt tcattcaggg gattgcggta tcaaatctag gacactgcca tgaagcggtg 1078981 acagaggcag tcaaaaaaca gcttgacagc gtatggcacg tatccaacct gtttcaaaac 1079041 agtctccaag agcaagcggc gcagaagctg gcagcgcata gtgcgggaga tcttgtcttt 1079101 ttctgcaaca gcggcgcgga ggcgaatgaa ggtgcgataa agcttgccag aaaagcaact 1079161 ggaaaaacaa aaatcatcac ttttcttcag tcgttccatg gccgcacgta tgcagggatg 1079221 gctgcgaccg gacaggataa aatcaaaaca ggcttcggcc cgatgcttgg aggctttcac 1079281 tacctgccat acaatgatcc ttctgctttt aaagctcttg gggaggaagg cgatattgcc 1079341 gcggtgatgc ttgaaacagt gcagggagaa ggaggagtca atccggcgag tgctgaattt 1079401 ttatcagccg tacagtcgtt ttgcaaggaa aagcaagccc ttctcattat tgatgaaatc 1079461 cagaccggca tcggacggac gggaaaaggc ttcgcatatg agcacttcgg actctcaccg 1079521 gatatcatca cagtcgccaa aggattggga aacggctttc cggtcggcgc tgtcatcgga 1079581 aagaaacagc ttggagaagc gtttacccct ggttctcacg gaacgacttt cggaggaaac 1079641 atgctggcga tggctgctgt gaatgccaca ttgcaaattg tattccagcc tgactttttg 1079701 caagaggctg ctgacaaagg ggcgttttta aaagaacagc ttgaggcaga gctaaagagc 1079761 ccttttgtta aacaaatccg aggtaaagga ttaatgcttg gaattgagtg tgatggcccg 1079821 gttgctgaca ttattgctga attgcagaca ttaggcttgc ttgtattgcc ggccggcccg 1079881 aacgtgattc ggctgctgcc gccgctcacc gtgactaagg atgaaatagc agaagccgtc 1079941 agcaagctga aacaggcaat cgctcatcat tccgctgtaa accagtgatt ttttttcgat 1080001 ataaaggcat aaaaattcat ttttataatt aattattcat caagaggtgg gctgttagat 1080061 ggaaggttat ttagtgttag aagatgggac atcgttcagc ggcgagctgg acggtcatga 1080121 aaactgcacg ggagaagctg tttttttcac aggaatgaca ggctaccagg aagtgctgac 1080181 agatccatca tataagggac agattattgt atttacctac ccgctgattg gcaactacgg 1080241 cataaatgaa aaggattttg aaagcaagaa accgcaagta aaagccgcgg ttgtctatga 1080301 ggcgtgtgat cacttttctc attatgaagc ggtatacagc ctcaaggagt atctacagaa 1080361 atggaatatt ccgctgttaa cccatgttga tacgagggct gtcgtgaaga aaatccgggc 1080421 aaacgggacg atgggtgcga cagtcacagc ctctaaagaa ggagctgaga ttgcccttca 1080481 accagagaat gtggcagagc aggcttccgc ccaggaaatc agcacattcg gcgacgggaa 1080541 taaacatatc gctctcattg attttggcta taaaaagtca atcgcatcat cacttgtcaa 1080601 acgaggctgc aaggttaccg tggtgccata ccagcaaatg gaggccgtat acaacatcaa 1080661 acccgatggg ctatcgaacg gacctggaga tccgaaagcc attcagccat atttaggaaa 1080721 gatcaaaagc atcatcagcc gctttccgac tctaggcatt tgtctcggac atcagctgat 1080781 cgcgctcgcg tttggaggga atacttttaa gctgccattc gggcacaggg gagctaatca 1080841 tccggtcatc gaccgtaaga cgaaacgggt ctttatgaca agccaaaacc acagctatgt 1080901 ggttgatgaa cagtcgatta atgaagaaga gctcaccatc aggtttcatc atgtcaatga 1080961 tacgtcagtt gaagggcttg cccataaaaa actgcctgtc atgagtgttc aattccaccc 1081021 ggaagcccat cccggacctg cggaaagcga atggattttt gatgattatc taaagaatgt 1081081 gataccagca aggagagaaa tcgcgcatgc ctaaagacac cagtatttca agcatattag 1081141 taattggctc aggcccgatc atcatcgggc aggcggcaga atttgattat tcaggcactc 1081201 aagggtgcat cgcgctgaag gaggagggct accgggtaat tctcgtcaac agcaatccgg 1081261 cgacaattat gactgatgaa gccttcgctg atgaaattta ttttgagcct ctgacagcag 1081321 aaagcctgac agccatcatt aagaaagaac ggcctgatgg gcttcttgcc aatttaggcg 1081381 gtcagaccgc gttgaattta gcggtggagc ttgaagaaac gggtgtttta aaagagcacg 1081441 gcgtcaaact cctcggcaca tccgttgaaa cgatacaaaa aggagaggac cgggaaaaat 1081501 tccgttcgtt aatgaatgaa ttaaaacagc ctgtgccgga gagtgaaatt gttgataacg 1081561 aggccgatgc cctccatttt gcggaatcca tcggttttcc tgttattatc agaccagctt 1081621 acacattagg cggaaagggc ggaggaatcg cccctgataa agaagccttt acagctatga 1081681 ttaagcaggc gctattagca agcccgatca atcaatgcct tgtcgaaaaa agcattgccg 1081741 gctttaaaga aattgaatat gaagtcatgc gtgacagcaa taacacatgc attaccgtct 1081801 gcaatatgga aaatatcgat ccggtcggcg tgcatacagg tgactctatc gttgtggcgc 1081861 cgtcacaaac attgacagac gaagactatc aaatgctgcg gacagcaagt ctgacgatca 1081921 tctcagcact tgatgttgta ggcggctgca acattcaatt cgcgcttgat ccattcagca 1081981 agcaatatta cgtcattgaa gtgaatccgc gtgtaagccg gtcatcggct ctcgcatcta 1082041 aagcgaccgg ttatccgatt gcgaagatgg ccgcgaaact ggcagtcgga tacactcttg 1082101 acgagctgaa aaatccgctc acaggctcga cttacgcaag ctttgaaccg gcactggatt 1082161 atgtgatcgt caaatttccg cgctggccgt ttgataaatt caaaaacgca gaccgcaagc 1082221 ttggcacaaa aatgaaagcc accggtgaag tgatggcgat tgaacggaat ttagaagcgg 1082281 cgatacaaaa ggcagccgcg tcgcttgaat taaaaaatat cgggacacac cttccagagc 1082341 tcagcgggtt gtcaattgat acgctatggg atttggcaat cactccggat gaccgcagat 1082401 ttttcgttgt catggagctg ttgagccgca gcgtctcgat tgatgacatc catgaaaaaa 1082461 caaaaattga tccgtttttc cttcatacct ttgacaacat catcaaattg gaaaaccgcc 1082521 tgatggaagc agggagcgat ctctcttttg aattattgaa gaaagcaaag gaaaagggat 1082581 tctcagacgc aacgattgcc tcgctgatca gcaaaacaga agaagaggtg cgcgcgcttc 1082641 gcaaggagat gggcattacg ccttccttta aaatcgtaga tacatgcgcg gcagagtttg 1082701 atgcgaaaac aaactatttt tactccacat atttcggaga gaccgatgga gacatcagcc 1082761 gcaaagagaa aaaacgcgcg ctcattatcg gatcaggccc gattcggatc ggccaaggcg 1082821 ttgaatttga ttacagtgct gttcacggtg tgctgacact gcaagagctt gggttcgaaa 1082881 ccatcatgat taacaataac ccggaaactg tcagcaccga ttatgaaatt gcggaccgcc 1082941 tgtattttga accgatgaca acggagcata ttgtaaacgt ggcggagcag gaaaatattg 1083001 attttgcaat tgtgcaattt ggcggtcaaa ctgcaatcaa tgctgctgaa gcgctcgaaa 1083061 aagccggcat tactcttctt ggcacatcat ttcaaacgct cgacgtgtta gaggatcggg 1083121 atcaatttta tcagcttctt gacgagctgg gattgaagca cgcaaaagga gaaattgctt 1083181 atacaaaaga agaagccgct tcaaaagcga gtgagatcgg ctatccggtg ttaatccgcc 1083241 catcttacgt tatcggcgga atgggcatga tcattgttga ctcgcaagcc cagctttctc 1083301 agctgctgaa tgatgaggac agcatgccat acccgatttt aattgatcag tatgtgtctg 1083361 gaaaggaagt cgaaattgat ttgatttccg acggcgagga agtctttatc ccgacatata 1083421 ccgagcatat tgaacgggca ggtgtccatt caggggacag ttttgccatt cttcccggac 1083481 cgtccatcac gagcgggctg cagcagggca tgaaagatgc ggcacaaaaa attgcccgaa 1083541 aactttcatt taaaggcatc atgaacattc aatttgtgat cgacaatgga aacatactcg 1083601 ttcttgaagt gaatccgaga gcgagccgca cggttcctgt cgtcagcaaa gtaatgggcg 1083661 ttccgatgat tccgctcgcc acacgtctgc tggcgggagc gtccttaaaa gatctaaatc 1083721 cggcagttca aaatcatcat ggagttgccg tgaagttccc tgttttttct tctcatgcga 1083781 tccaggatgt ggatgtcaag cttggaccgg aaatgaaatc aacgggagaa ggcatgtgtg 1083841 tcgcatatga ttctaacagc gccttgaaaa aaatctatac aagagtctgg agtcaaaaag 1083901 gaagcattta tttgcaaaac gttccggaag atgtgaagga gttagcagaa aacgcaggtt 1083961 ttacaataca tgaaggaaca tttgcctcat ggatggaaca ggaaggaaac tcgctccaca 1084021 ttaatctgag cggttctgaa gaagcacgca aagaacgttt ggaagccatg acgcacggca 1084081 tccccgtctt tacagaagaa gaaactgtgc gggcgttttt acaaagcggt tcaggccatc 1084141 cgcagcctgt atctctcaaa gacctctata aaaaggaagt ggcatcatgc acacagtgac 1084201 gcaaaccagt ttatacggaa aagatttatt aacgttaaag gaccttagtg aagaagatat 1084261 aaacgccttg ctcgcagaag ccggtgagct gaaacaaaac aaaattcagc ctatattcca 1084321 tggcaaaacc ttggcgatga tttttgaaaa atcatcaacg cggacccgtg tttcatttga 1084381 agcgggcatg gcgcagctgg gcgggagcgc cctctttcta agccagaaag atctgcagct 1084441 ggggcgcggt gagactgtcg ctgatacggc aaaagtgctg tcaggctatg tggatgccat 1084501 catgatccgg acctttgaac atgaaaaggt ggaggaactt gccaaagaag ctgacattcc 1084561 ggtgatcaat ggacttaccg ataaatacca cccatgccag gcgctggcgg atctcttgac 1084621 gattaaggag ataaaaggga agcttaaagg cgtaaaagtc gcgtacatcg gtgacggaaa 1084681 taacgtggcg cactccttga tgatcggctg cgcgaaaatg ggctgtgata tctcgatcgc 1084741 ttcaccaaag ggatatgaag tgttagatga agcagctgaa gcggcaaaga catatgcact 1084801 tcaatccggc tcttctgtca cgctgacaga tgatccgatt gaagctgtaa aagacgcgga 1084861 cgtgatttat tctgatgtgt ttacaagcat ggggcaggaa gcggaagagc aagaacgtct 1084921 tgctgtcttt gcgccttatc aggtgaatgc ggcgctggtc agccatgcca agcctgacta 1084981 tacattttta cattgtctcc ctgcgcatcg cgaggaagaa gtgactgcgg agattattga 1085041 cgggccgaac tctgcagtgt tccagcaggc ggaaaaccgt cttcatgtgc aaaaagcact 1085101 gctgaaggcc attttatata aaggggaatc atcaaaaaac tgctgagcca aactcagcag 1085161 tttttttgat ggcaacatat tcacagccgc ttaggcgcat actacagcaa aaaggaaaag 1085221 gaggaaaaac agtgggacag cagcaccaat tccggcccgg acagaaagcg cctaataacg 1085281 gtgtctacgt agaaatcggc gagacaggga gcatggttaa aaaccctcaa aaggtccatc 1085341 tgtcagcagg ggaaatgttc cccgaaacat caaaccacaa ccggctgtgg acctacaaaa 1085401 gaaagccgtg accactaaaa aacccaaaac aataaatgtt ttgggttttt ggctttttaa 1085461 tgctggcttg catttttgtt cataggcatg atttctgcta aaaccatgat taagacatac 1085521 agtacaacag caatgacaga tgatgttttg aaattatacg taacgctgtt catgcttgca 1085581 accaagtagc atgccatatg tgataaaagg aacgtccaaa taaaggcaat aatatatcgc 1085641 acgtttccac ctcgtccttc tcattctatt ctaaaagtta tcataccata caaaaagcga 1085701 agggggaatc caattttagc agaaagtgag gtgacaaaag agtctgattc gtcacacttt 1085761 aatggtaaaa tataaaacgt caatcagtat aatagccaaa aatgtaaaag gctaggactt 1085821 taccttattc gtttcttttc tatttacata agatagcgtg agatgaagtg tgaaaggagg 1085881 cgggcaagcg atgggaataa cggaaagata ctttcaactg ggaacggagc ataatgtcat 1085941 tcatctgccc tatcgcccga acggcttcgg catctttatc ttgggggaca gaacccactt 1086001 tgtcggacat gattcaagct tttggcagca gcattatggc agaaatcagc ttctgagcat 1086061 gttgatgaat gaaggataca ctctttttaa cagcaatctg ttcggaaggc attggggggc 1086121 ggaaaaagca gtcacctatg ccaaacagct gatacattct gtgctgaagc aggaaatcct 1086181 caatccgaag attcatattt tagcagaagg catgggtgct ctcgtggccg atgaactgct 1086241 tcgtttttcc ccggatcata tccgctcagc cgcaatgttg aatccttgtc tcgatcttca 1086301 ggcacattat gaatcggaaa aagaaaataa atttttctat aagcaatttt tgaaagaagt 1086361 atcgaaaagc tacggaattt ctgaaaaaga agcggaagcg attcgttata aaacaattca 1086421 aagctacccg agcggcgtac cggttcatat atggcagcgt atgaccggag ctccatatcc 1086481 ctacagcgta catgcggaag ttttcaagga aaaacagcaa aagcaaggct caccggtcga 1086541 catgacattt catttatttg agcatccaag cagaatttat gcatcaattt gcaaattctt 1086601 tcatagtcat gaaaaagaat tatagagaat ataatgacaa cagccttctc ttttgcggag 1086661 gctgttttgt tttgggaaat gaaaaaccgg aagggcggca gatgcaatgg aatcaacgct 1086721 gattgtaggt gcggacgaat ttttcggcct ttcattatgt gagcgaatga tggatgaagg 1086781 catacatgtt gacgttgttc tggcggaaac agaagataaa atgagacaaa tgtacttaga 1086841 agaaagactc atgtggcttg ggagaaatga actctttcgc cagcttgaac acattggaga 1086901 ccaaaattat gatacaattt gtatccagtt cggaagtttt ttgcctttag accaatatga 1086961 ttctccttat attttagtat atgaagaaga ccgaaaagaa tgggataaac gtgaaaaaac 1087021 aggctcggaa aaaaccgtga tcctgccgaa aatgtacggg ccatggaaag aagaaacaga 1087081 ggaagacggc tattacacaa acgacgtggc tgacgagttg ctgagattcc tgttagaacc 1087141 aagccgtcat agcaaagatc agctttttga attgcaagtc acagagaaaa cctcaaaaga 1087201 agaagcaaaa acaaaaatta tcgagtggaa aagacaattt tcatcaattt tcgacaaata 1087261 ttaagaaaaa ccttccatgt ttcgagtttt ctagatacaa taaacgtata aaaataatac 1087321 atgttatagc ttgtcaaaag gagttgaaca tgacttgatc acaaggcttg tcatgatctt 1087381 ttctgtcctc cttttattga gtggatgtgg acaaactccg ttcaaaggaa aaattgagaa 1087441 ggtcggcatg ctctttcctg atacgattaa tgacctcgta tggggcacaa aagggtataa 1087501 aggattactg aatatacaat ccaaatacaa tgtggacgtc tattataaag aaggcgttaa 1087561 aacagaagaa gatatcataa atgcgattga ggattttcat aagaggggcg tcaatctgct 1087621 ctacggccat gggagtgaat atgctgaggt gtttaacttg gtcggcgaag attatccaga 1087681 tatggaattc gtcatttcca atgcgaaagc gaaagctgat aatgtaacaa gtgtccattt 1087741 tagcggggaa gcaatgggct tttttggagg aatgactgct gcccatatgt cgaaaacgaa 1087801 tcaggtcggt gtaattgctt cctttacgtg gcagcctgag gttgacggtt ttatcaaagg 1087861 ggccaagtat gaaaatccgg atatagaggt aaatacgaaa tatacggatc attgggatga 1087921 tgatacaaca gcagtaaagc tttatcagaa aatgaagaac gaaggcgcgg atgttgtgta 1087981 tcccgccgga gacgggtata atgttcctgt tattcagcaa atcaaaaaag acggtcttta 1088041 tgccataggc tacgtcacag atcaatcgga tctgggcgag aataccgtat taaccagcac 1088101 ggtgcaaaat gtggacaagg cctatgaaat cattgctgaa caatttaata aaggcaccct 1088161 tgagggcggc gatcattact acgacctgaa cacgggagtc gttgagatgg gaacattcag 1088221 cccgctcgtc gatcaagact ttcagcaaag aatcgccaag ctgatcaaaa catacaacaa 1088281 aacaggcgag ctgccaaaaa acgagtaatg gagtgacgtc acatgcagca cgaaaaatca 1088341 cttgaattct tgcaaattgc catgaaatat ctccctgaag cgaaagaaca gcttgagaaa 1088401 tcaggcattg agctctcaat ggaggccatc cagccgttta tgaatctatt tacaacggta 1088461 atggcggaag cttatgagct tggcaagtct gacgctaaat ctgaaacaga ataagaagaa 1088521 gccacttttt tgaaagtggc ttttcacatg attttctttt taatagcgga gagcatgggc 1088581 gcaagctcct ttaaagcggg cttgatttga tcaagagagt tcataattga accgatttgg 1088641 tccataatat gcatgtaatt aatcgtctct tcgtcgtttg tctgagaaac ctgagaaact 1088701 tcctcttgct gttcctcctc cttctcttct gttggttttg ctgcatcgcc gaacatcatt 1088761 cttgaaaaca catccaactg catacgcctc ctttccatat accatactct atgagtaaga 1088821 tgaactgata gtttagacga atatattgcc atgtgaaaaa aaataggata gaattagtac 1088881 ctgatactaa taattgatca caacctgatt gatcttctaa atttaagata taaaggagtc 1088941 ttccctaatg aaagctggaa tacttggtgt tggacgttac attcctgaga aggttttaac 1089001 aaatcatgat cttgaaaaaa tggttgaaac ttctgacgag tggattcgta caagaacagg 1089061 aatagaagaa agaagaatcg cagcagatga tgtgttttca tcacatatgg ctgttgcagc 1089121 agcgaaaaat gcgctggaac aagctgaagt ggctgctgag gatctggata tgatcttggt 1089181 tgcaactgtt acacctgatc agtcattccc tacggtctct tgtatgattc aagaacaact 1089241 cggcgcgaag aaagcgtgtg ctatggatat cagcgcggct tgtgcgggct tcatgtacgg 1089301 ggttgtaacc ggtaaacaat ttattgaatc cggaacctac aagcatgttc tagttgttgg 1089361 tgtagagaag ctctcaagca ttaccgactg ggaagaccgc aatacagccg ttctgtttgg 1089421 agacggagca ggcgctgcgg tagtcgggcc agtcagtgat gacagaggaa tcctttcatt 1089481 tgaactagga gccgacggca caggcggtca gcacttgtat ctgaatgaaa aacgacatac 1089541 aatcatgaat ggacgagaag ttttcaaatt tgcagtccgc caaatgggag aatcatgcgt 1089601 aaatgtcatt gaaaaagccg gactttcaaa agaggatgtc gactttttga ttccgcatca 1089661 ggcgaacatc cgtatcatgg aagctgctcg cgagcgttta gagcttcctg tcgaaaagat 1089721 gtctaaaact gttcataaat atggaaatac ttctgccgca tccattccga tctctcttgt 1089781 agaagaattg gaagccggta aaatcaaaga cggcgatgtg gtcgttatgg tagggttcgg 1089841 cggaggacta acatggggcg ccattgcaat ccgctggggc cgataaaaaa aggtgaggtg 1089901 cacacaagat gactaaaaaa agagtagttg ttacaggact tggagcatta tctccacttg 1089961 gcaacgacgt cgatacaagt tggaataacg caatcaacgg tgtgtccgga atcggtccga 1090021 tcactcgtgt tgacgctgaa gaatatccgg caaaagttgc cgctgaatta aaagatttta 1090081 atgttgaaga ttatatggat aaaaaagaag ccagaaaaat ggaccgcttt acacaatatg 1090141 cggttgtggc tgcgaaaatg gcggttgaag atgcagatct taacattacc gatgagatcg 1090201 cgccgagagt cggtgtttgg gtaggctccg gtatcggagg acttgaaaca ctagagtctc 1090261 aatttgaaat cttcttaaca aaaggcccaa gacgggtaag cccgtttttc gtgccaatga 1090321 tgattcctga catggcgaca ggccagattt ctattgcatt aggagcaaaa ggggtgaact 1090381 cttgtacggt tacagcatgt gctacaggaa cgaactccat cggtgacgcg tttaaggtta 1090441 ttcagcgcgg tgatgcagac gtgatggtca caggcggaac agaagcgccg ctgacaagaa 1090501 tgtcattcgc cggctttagt gccaacaaag cgctgtctac taatccagat ccgaaaacag 1090561 cgagccgccc gtttgataaa aaccgtgatg gctttgtcat gggggaaggt gcagggatta 1090621 tcgttcttga agaacttgag catgccctgg cccgcggcgc taaaatttac ggagaaattg 1090681 tcggctacgg ctcaaccgga gacgcttatc atatcacagc gccggcccaa gacggtgaag 1090741 gcggagcgag agcgatgcaa gaagccatta aagatgcagg cattgcacct gaagaaattg 1090801 attacatcaa tgctcacggg acaagcacgt attacaacga caaatacgaa acaatggcga 1090861 ttaagaccgt ttttggcgag catgcgcata aacttgcggt aagctctaca aaatcgatga 1090921 caggccacct cttaggagca gccggcggta ttgaagccat tttctctatc ctggccatta 1090981 aagaaggcgt gattccgccg acaatcaata ttcaaacacc tgacgaagaa tgtgatttgg 1091041 attatgtgcc tgatgaagcc cgcagacagg aacttaatta tgttctcagc aactcattag 1091101 gattcggcgg acacaacgca acattaatct ttaaaaaata tcaatcataa tcaagccaaa 1091161 ccggctgccc ttaaagggta gccggttttt tttgtgtgca taggattaaa agaggaggcg 1091221 atcacatgag tgtagaacaa acatatagct ggctcaggaa ggccggttca atagatgatt 1091281 tggcgcatta cattatcccg cttttttcag gtgcggagaa aaagaactgg aagggcattc 1091341 tggggcatct tcagcatcat gggatgttta aaaacataaa agagggtatt cagacggttt 1091401 ccaagctgaa ggaaaaaggt ttttacggac atatccaaaa ggaagaacag tacctcaaaa 1091461 acaaatggca aggtcctgat gtaccaattg ttacgctgcc ggttgatgaa cgaaacagga 1091521 gaatccgttt agaattcgga tcaaaatcag gactcgcctt tcaagacaaa atgttccttt 1091581 ttctttcgtc agatttagat tttgggtcgg tatctgccct tatgacgcat gagtatcatc 1091641 acgtttgccg gttaggtcat ctgacaaaag aggaaaagga tgtcacatta cttgatacaa 1091701 tcatcatgga agggctggcg gaatatgctg tttatgagag gttcggccga agtcaaacgg 1091761 ctgaatggac gacttggtat acaccggaac agcttcaggc tttatatgaa aaaaagattg 1091821 cgccccatcg ggatatcaaa cgggataatc gattatttcc ccagctgtta ttcggcaaag 1091881 gatatcagcc aaaaatgctt ggatacgcag ttggattcaa tattgtaaaa aaatatttaa 1091941 ccgccagcaa ggcaagcacc gcagacgggc tgtccattcc tgctgagacc tttttggatg 1092001 caatgcttta aaaggataaa ataatggaat ttcattaata atattacatt tatcctaaaa 1092061 aattcttgat tttgcaaaat gattgtaata atatacaact ataaaatttt tcgataattc 1092121 aatattattt attatttctg aataaaggga ttgctttctc ttgaaaacgt ttgacaacaa 1092181 gaggggggaa aggggagcta gcatgagcac acttttagaa gtgaataatt taaagactta 1092241 ttttttcagg aaaaaggagc cgatccctgc ggttgacgga gtcgattttc acatcagcaa 1092301 aggcgaaacc gtcgcgcttg taggtgaatc gggctccgga aaaagcatta cttctttatc 1092361 aattatgggc ctcgtccaaa gctcaggcgg aaaaatcatg gacggctcta ttaaactcga 1092421 agacaaagac ctcacctcat tcactgaaaa cgattattgc aaaatccgcg gtaacgaagt 1092481 atccatgatc tttcaggaac caatgacctc ccttaatccg gtgttaacaa tcggagaaca 1092541 aattaccgaa gtgctgattt accataaaaa catgaagaaa aaagaagccc gtcaacgagc 1092601 tgttgaactc ttgcagatgg tcggtttctc ccgggcggag caaattatga aggagtaccc 1092661 gcatcggctg tccggcggta tgagacagag ggtgatgatt gccatcgcac tgagctgtaa 1092721 tcctaaactg ctcattgctg atgaaccaac gacagcgctg gacgtgacaa tacaagccca 1092781 ggtgctggag ctcatgaaag atctctgtca gaagttcaat acatcgattc ttctcatcac 1092841 acacgactta ggtgtcgtgt ctgaagctgc cgatagagtg attgtcatgt actgcggaca 1092901 agtcgtagaa aacgccactg ttgatgactt atttttagaa ccgcttcatc cgtatacaga 1092961 aggcctgctt acgtcaattc ctgttataga tggagagatt gataaattaa atgcgattaa 1093021 aggcagtgtg cctacaccgg ataatctgcc gccggggtgc cgttttgccc caaggtgccc 1093081 gaaagctatg gataagtgct ggacaaatca gccttcgctt ttgacacaca aaagcggaag 1093141 aacggtgaga tgctttttat atgaggaaga gggtgccgaa caatcatgac agcagctaat 1093201 caagaaacaa tcttagagct tcgtgacgta aaaaaatact ttccgatccg gtcaggcctt 1093261 tttcaaagaa aagtcggtga tgtaaaagcg gtggatggtg tttcattttc gttaaaaaaa 1093321 ggagaaacac tcggaatcgt tggagagtcg ggctgcggaa aatcgactgc cggcagaacg 1093381 atgatcagac tgtacaaacc gacagagggc caaattcttt ttaaagggca ggatatttcc 1093441 aatctgtcag aggagaagct gcggaagagt gtccgcaaaa atattcaaat ggttttccaa 1093501 gatccatttg cttcgttaaa cccgagaaag accctgcgtt ccatcataaa ggagccgttt 1093561 aatacgcaca acatgtatac catgcgtgaa cgaaacgaaa aagttgaaga gctgcttgca 1093621 agagtagggc ttcacccgtc gtttgccggc cgttatcccc atgagttttc aggcggccag 1093681 cgtcagcgga tcggcattgc cagagcactc actttgaatc cagagctgat cattgcagat 1093741 gagccggttt ccgcacttga tgtatccatt caggcccaag tgattaactt gatggaggaa 1093801 ttacaggaag aatttaatct tacgtatcta tttatctctc atgatctgag tgtcgtccgc 1093861 catatcagcg acagagtcgg agtaatgtat cttggcaaaa tgatggaact gaccggcaag 1093921 catgagcttt atgacaaccc gcttcaccca tatacccaag cgcttttatc ctccgttccg 1093981 gttacaagaa aaagaggttc tgtcaaacgt gaacgcattg tcctgaaggg agaactgcct 1094041 agtccggcca acccgccaaa aggctgcgta ttccacacaa gatgtcctgt tgcaaaaccg 1094101 atatgcaagg aacaaatacc agaatttaaa gaagctgctc ccagccactt tgtggcttgt 1094161 cacctttata gctaatgttg cccgcacagc tttgagaggg ggtatgcaca ctacataaac 1094221 aacagcctag aagaacgaac atttcaagag ggggaatatc taatgaaaag acggaaaacc 1094281 gcactgatga tgctaagtgt attgatggtt ctggccatct ttttatcagc ctgctcggga 1094341 tcaaaatcaa gcaacagcag cgcgaaaaaa tcagcaggca aaccgcagca aggcggggat 1094401 ttggttgttg gttcaatcgg agaacccaca ctttttaact ctctgtattc taccgatgac 1094461 gcaagtacgg atattgaaaa tatgctgtac agctttttaa cgaaaacgga tgaaaaacta 1094521 aatgtgaaat tgtcactcgc tgaaagcatt aaagaattag acggcggcct tgcatatgat 1094581 gtgaaaatta aaaaaggcgt taagtttcat gacggaaaag aactgactgc agacgacgtc 1094641 gtatttacgt acagtgtccc tttaagcaaa gattacaagg gagaacgcgg ttcaacatat 1094701 gaaatgctga aatccgtaga aaaaaaggcg attacgaagt cttgtttaag ctgaaatata 1094761 aagacggtaa tttctacaac aatgcgttag acagcacagc tattctgccg aaacatattc 1094821 tcggtaatgt tccgattgct gatttagaag aaaatgagtt taacagaaag aaaccaatcg 1094881 gttcaggacc atttaagttt aaggaatgga agcagggcca atatattaag ctcgaagcga 1094941 atgatgatta ctttgaagga agaccgtatt tagatactgt gacgtataaa gtcattcctg 1095001 acgcaaatgc tgccgttgct cagctgcagg caggcgatat taatttcttt aatgtgcccg 1095061 ccactgacta caaaacggct gaaaaattca acaacctaaa aatcgttact gatttggcat 1095121 taagttatgt gtacatcggg tggaatgaaa aaaatgaatt attcaaggat aaaaaggttc 1095181 gtcaagcgct aacaaccgct cttgaccgcg agtcaatcgt cagccaagta ttagatggag 1095241 acggcgaggt agcttacatt ccggaaagcc ctttatcttg gaactatcct aaagatatag 1095301 atgttccgaa atttgagtac aacgagaaaa aagcgaaaca gatgcttgca gaagccggct 1095361 ggaaagatac gaacggtgac ggcattctgg ataaagacgg aaagaaattc tcgtttaccc 1095421 ttaaaacgaa ccaaggaaac aaagtccgtg aagacatcgc tgtcgtcgtt caggaacagc 1095481 tgaaaaaaat cggcattgaa gtgaaaaccc agatcgttga atggagcgct ctcgttgaac 1095541 aaatgaatcc tccgaattgg gattttgatg caatggtcat gggatggagt ttatccacat 1095601 tcccggatca atatgatatt ttccattcaa gccagattaa aaagggtttg aactacgttt 1095661 ggtataaaaa tgccgaagcg gataaactca tgaaagatgc aaaatcaatc agtgacagaa 1095721 agcagtattc aaaagaatat gagcaaatct atcaaaaaat tgcggaagat cagccgtata 1095781 cgttcttgta ttatcctaac aaccatatgg caatgccgga aaatcttgaa ggatacaaat 1095841 atcatccgaa acgtgatttg tataatattg aaaaatggtg gcttgcaaaa taaatttccc 1095901 ttaaagggga gggagagcgt tttctccctc ttctgttttt aataaggaaa gtaaaggggg 1095961 acaagtatat ggctgcatat attatcagaa gaaccttaat gtctatcccg attttattgg 1096021 gaattacgat tttatcattt gttatcatga aagccgcgcc cggagatccg atgacattaa 1096081 tgatggaccc gaaaatcagc caggctgaca gagagcagtt tattgaaaaa tacggtctga 1096141 atgatcctca gtacgttcaa tatttaaagt ggctaggcaa catggtgcag ggtgatttcg 1096201 gaacgtctat tgtcagaaaa ggaacgcctg tttcagaatt gattatggca agactaccca 1096261 atacgctcct gctgatgctg gtttcaacga ttttggctct tatgatttct attccgttcg 1096321 gtgtcctgtc ggcaaagcgg ccgtattcaa aaatcgacta tggcattaca tttacctcgt 1096381 ttataggcct ggctattcca aacttttggt ttggattaat tttgattatg gtgttatcgg 1096441 taaatctcgg ctggtttcca actgggggtg tcgagacact gaataccgaa ttcaatatat 1096501 ttgaccggat tcatcattta attctgcctg cattcgttct agctacagct gacatggccg 1096561 gactgacgag atacacgaga tccaatatgc ttgatgtatt aaatcaagat tatattcgca 1096621 cagcgagagc aaaaggattt aaagagaaca gagtgctatt taaacatgga ttgaggaatg 1096681 cattattacc cgtcattaca attttcggtt tgatgattcc ttcatttatc ggcggatctg 1096741 tcgttgtcga acaaattttc acttggccgg gattaggaaa gctgtttgtc gattcagcat 1096801 tccagcgcga ttatccggtt atcatggcaa tgactgtgat ctcggcggtt cttgtcgttg 1096861 tcggaaacct cattgcagac atcctttacg cgattgttga tccgcggatc gaatattaaa 1096921 aggagggaaa cagagatgtc agagctgcaa acaactccct cgccggagat caggctgaaa 1096981 gaaaatattt cgaaaaagcc agaaacaatg acaaagattt tctgggaaaa attctcgaaa 1097041 aacaaactgg ccattttagg tgccgttatt ctttttatca ttattatgtc tgctgttttc 1097101 gcccctttaa ttgcacctta tccccaagag cagcaaagcc tgcttgataa atataaggcg 1097161 ccgggccttg aacatctgat gggaacggat aaatttggac gtgatatttt cagccggatc 1097221 ctatatggag cgcgtgtctc tttattggtt ggatttgcgt ccgtagtcgg ttcgattttg 1097281 atcggaacgg ttttaggagc attagccgga tatttcagag gaatagtgga tgctgtcatt 1097341 atgcgtgtag ttgacattgt gttatccatt cctgatattt tcttgttgat cacgctggtc 1097401 accatcttca agccgggtgt ggacaaattg attttaattt tctgtctcac aggatggacc 1097461 acaacagcac gattagtaag gggagaattc ttgtcgctcc gttcaaggga atatgttctt 1097521 gctgctaaaa caattggaac aaaaacgcac aaaattattt tttctcatat cctgcccaat 1097581 gcgttagggc cgattatcgt gtcagctacg ctgaaagttg ggtctgttat tctagctgaa 1097641 tcggcgctaa gctacttggg ctttggaatc cagccgccaa tcgctagctg ggggaacatg 1097701 cttcaagacg cacagaattt cacagtaatg attcaagcat ggtggtaccc gttatttccc 1097761 gggctattta ttttaatgac cgttttatgc ttcaactttg tcggtgatgg cctgcgggat 1097821 gcgcttgacc cgaaaaatat taaataaaaa tgaatatcat atctgttata aaatatcacc 1097881 aaatcagaaa aaagcaggtc tcctttagtc agaaaatata caaagagatc tgctttttat 1097941 gattcttaca taaacccagt gattccagat ttcctcaatc tctttggaat aatttctcta 1098001 tcccttgcct atactgtgga caacagtttt tataaaagtg aggggttaga gatgttattt 1098061 cttcatgatg tgtgggtcaa ttggtttgaa ggggaagaaa atggctacaa tgtatgccac 1098121 tttcacgaat ggcgcaagga agatacggtt gagcttttgg atcaggtgcc gctgttaagg 1098181 gtgccgtcag tactgtttca ttacatagaa aacgatttgt cagagcttcc gaaaggtttg 1098241 cttgaagacg tacatcagaa atcgtacatt cgaaaaaatc atgagcggac aaagcttgag 1098301 tattgttttg tcgtaacaga cggaatcggc attttagctg ttgacacgat cggctacacg 1098361 atccctgtca gaaaaagccg tctaatccca agacaggagc agctcgttta tgaaatggta 1098421 aaagatgtag agcctgaaac atatgaattt gagccaaaga agctggaatc ctccaaggaa 1098481 tatcacatct tatcattagc accagaacat gtcagaggac tgacaagaaa agaacggcaa 1098541 attaagcagc tgatgtttat ggcgcttgac caattaaaag ggctgaaaaa ccgagcggaa 1098601 attggctact ggtacacaga gtggaatccg catatgtatg aacaaatcaa aaggatgagc 1098661 tttgaagaga tttgggacat gctgtataac gaaacaattg aaggctggtc ggacaaacac 1098721 ctagcttttt gcgaaaacct aataaaagga cagccttttt tcgaaaagct ttgggaaatg 1098781 gaaaacgaat caaaggtcaa ctgaaaaaaa ccgctctttg caaagagcgg ttttttgatt 1098841 agcgtctttt tcttccaaga cccatggcat tctccatttt tttcagcatt ttgtttgctg 1098901 tccgattcgc tcgttccgcg ccttcatcaa gaatccggtc taattcttca gattctatca 1098961 gctcgtaata gcggtcctgg atcggtttta atgcgttcac tacgacttct gccaaatcac 1099021 ctttaaactc gccgtagcct tttccttcgt actttgcttc aagctcttca attgtcgtat 1099081 tgccgaggat tgaataaatt gtaagaaggt tggaaacgcc cggtttgttt tccttatcaa 1099141 atttgacaat gccttcagaa tccgttactg cgcttttgat tttcttttca agctgcttcg 1099201 gctcatccag caatgtaata taagctttct gattcggatc agatttgctc attttcttca 1099261 gcggatcatt cagagacatg atacgtgcac cgacttttgg aattttcact tccggaatcg 1099321 taaagatgtc gttgtatttt ttgttgaagc gttctgcaag attccgcgtc agctcaaggt 1099381 gctgcttttg atcctcgccg acaggtacaa gatccgttcc gtacagcaga atatcagcgg 1099441 ccatcagcgg cggatatgtt aacaggccgg agacgacagc ttcattgcct ttggatttgt 1099501 ccttaaattg agtcatccgc tcaagctcgc cgatataggc gacacactgc atcatccatc 1099561 cggcctgcgc atgtgcgggg acctctgact gaataaacaa tgttgctttt tctggatcaa 1099621 gtccgacagc taagtaaagc gccgcgagat tgcggatatt ctttctaagc tcaagccggt 1099681 cttgaggaac agttatcgca tgctgatcga cgatgcaaaa atagctgtta taatcatgct 1099741 gcagttcgac aaactgcttc attgcaccga tatagttgcc gagcgtcact gagccgcttg 1099801 gctgaatgcc tgaaaaaatc gtttgtttca tgaaaacatc aacctcattt cttaaaacat 1099861 aataaaaaag gctcattctt cccctgtaaa aaagggacga atgaaccgtg gtaccaccct 1099921 gattattcca ttaaaatgga atcactctga cgtttgtaac ggagactgct ccggctgagc 1099981 ctactttttt ccagttcggt cagctgctcc aaagtccatt ccacattgcc cgttatctgc 1100041 tcccagcacc gcagactctc ttcaaacagg tgaaacgtgt actactcttt ttcatagcaa 1100101 gcttttcttt tgattgcttc attataaatc aattataacc aattgtcatc atgaaaaaac 1100161 attctttttt ccagtaaaat tgtaataata taaataacac gagtgctgta aaatccttaa 1100221 atgataactg ctatcagcgt aaaaacaggc agatattata tgtaaaaagc aatatgggca 1100281 gaaaacacat gaaaaagttt ttaatcaatt tatgctttaa atggtagaag gatattatgt 1100341 tcatggaaga aaaactaacg aagtttaaat attttaaatt gataaaataa tattgcaata 1100401 aattatttgt ttcattataa tgaacttgtt cactctattg ttacagcttt tttacaaaaa 1100461 taatcagaaa agacggaaca gaataaaagt tgtggaaact caggttcatt tgtctgatat 1100521 ttctgaggat ttagccgtaa ggagctgaaa attattatta gggggtttgc gaatatgaaa 1100581 aaacgttggt cgattgtcac gttgatgctc attttcactc tcgtgctgag cgcgtgcggc 1100641 tttggcggca gcggatcaaa cggtgaaggg aaaaaggaca gtaaaggaaa gacgacactt 1100701 aacattaata ttaaaactga gccgttctcc ttacatccgg gattggcaaa tgattcagta 1100761 tcaggcggtg ttatccgtca gacttttgaa ggattgacac gtatcaatgc agatggtgag 1100821 cctgaagaag gcatggcttc taaaattgaa acgagcaagg acggaaagac atatacattt 1100881 accattcgtg atggtgtgaa atggtctaat ggagaccctg taactgcaca agattttgaa 1100941 tatgcttgga aatgggcgct tgaccctaat aatgaatcac aatacgctta ccagctctac 1101001 tacataaaag gtgctgaagc ggcgaatacc ggaaaaggca gcctagacga tgtggcagta 1101061 aaagctgtga atgacaaaac gctgaaggtt gaattaaata acccgactcc atatttcact 1101121 gaattaactg cgttctatac gtatatgccg atcaataaga aaattgcaga gaaaaataaa 1101181 aagtggaata caaatgccgg agatgattat gtatcaaacg ggccgttcaa aatgacggca 1101241 tggaaacaca gcggctctat tactctcgaa aaaaatgacc agtattggga taaagacaaa 1101301 gtcaaactga agaaaatcga tatggttatg atcaacaata acaatacgga actaaaaaaa 1101361 ttccaagctg gcgaacttga ttgggccggt atgccgctcg gacagcttcc gacagaatcc 1101421 ctgccgaccc tgaaaaaaga cggttcttta catgttgagc cgattgcagg agtgtattgg 1101481 tacaaattca acactgaagc taagccatta gacaacgtca atatccgtaa agctttaaca 1101541 tattcgcttg accgtcagtc gattgttaaa aacgttacgc aaggagagca aatcccggca 1101601 atggctgcag tgccgcctac aatgaaggga tttgaggata acaaagaagg atacttcaaa 1101661 gacaatgatg tcaaaacagc aaaagaatac cttgaaaaag gcctaaaaga aatgggctta 1101721 agcaaggcat ctgatttgcc aaaaatcaaa ttgtcttaca acactgatga cgcacacgcg 1101781 aaaatcgctc aagcagtaca agaaatgtgg aagaaaaatt taggcgttga tgttgagctt 1101841 gataactcag agtggaatgt ctatattgat aagctccaca gccaagatta tcaaatcggc 1101901 cgtatgggct ggctcggcga cttcaatgat cctatcaact tccttgaatt gttccgcgac 1101961 aaaaacggag gaaataacga tacaggctgg gaaaatccag aattcaaaaa gcttctgaat 1102021 cagtcacaaa ctgaaacaga taaaacaaaa cgtgcagagc tgctgaaaaa agcagaaggt 1102081 attttcattg atgaaatgcc ggttgcccca atctatttct atactgatac ttgggtacag 1102141 gatgaaaacc taaaaggtgt tatcatgcca ggtactggtg aggtttattt cagaaacgca 1102201 tattttaaat aaggctacgt ctgaaaataa aagacctcaa ggtatatggg gagaaaagcc 1102261 ccatatacct ttcttactga tggagtataa aaatgtaaaa accatggagg tgttccccct 1102321 tgctaaaata tatcggaaga cgcttagtct atatgattat cacactattt gtgattgtaa 1102381 ctgtgacatt cttcttaatg caagcagcac cgggcgggcc attttcaggt gagaaaaagc 1102441 ttccgcctga aattgaagca aatttaaatg cgcattatgg cttggacaag ccgctgtttg 1102501 tacaatatgt cagttatttg aaatcagttg caatgtggga tttcggaccg tcatttaaat 1102561 ataaaggtca gagtgttaac gacctgatca gttcaggttt ccccgtttca tttactcttg 1102621 gagcagaagc tattctcctc gctttagcgt taggtgtatt gtttggggtc attgcagccc 1102681 tttaccataa taagtggcag gattataccg tcgcgatttt aacgatattt ggtatttcgg 1102741 ttccgagctt tatcatggcg gctgttctgc aatatgtgtt ctccatgaag cttgggctgt 1102801 ttccggtcgc ggggtgggat tcctgggcat acaccttttt gccttccatc gcacttgctt 1102861 ccatgccgat ggcgtttatt gccagacttt cccgttcaag catgatcgaa gtgttaaaca 1102921 gtgattatat ccgcacagcg aaagcgaaag ggctttcccg cccagcggtt acagtgcggc 1102981 acgccattcg aaacgcactt ttgccggttg ttacatatat gggcccgatg gccgcacagg 1103041 tcttaacggg gagcttcatt attgaaacca tttttgggat tccggggctt ggtgcacact 1103101 tcgtcaacag tattacaaac cgtgattata cggtcattat gggtgtaacg gtgttcttca 1103161 gtgtcatctt gctattgtgt gtattaatcg tagatgtgtt atacggcatt attgatccaa 1103221 gaatcaagct ttccaaagca aagaaaggag cctaggccat gcagaacatt ccaaaaaaca 1103281 tgtttgaacc agccgcagcg aatgccggcg atgcagaaaa aataagtaaa aagagccttt 1103341 ccctctggaa agatgcgatg cttcgcttcc gcagcaataa gcttgcaatg gtcgggctta 1103401 tcattatcgt acttattatc cttatggcaa tttttgcgcc gatgttctca aggtatgatt 1103461 attcaactac taatctctta aatgcggata agccgccttc aaaagatcac tggttcggaa 1103521 cagatgatct tggacgggac attttcgtcc gtacatgggt aggggcgcga atctcaatct 1103581 ttatcggtgt tgcagctgct gttctcgatt tgctgatcgg cgtcatttgg gggagcattt 1103641 caggcttccg cggaggaaga acagatgaaa tcatgatgcg tatcgctgat atcctttggg 1103701 cagttccttc attattaatg gttatcttac tgatggttgt tcttccgaaa ggtctattta 1103761 cgattattat tgccatgacg attacaggct ggattaatat ggccagaatc gtgcgcggac 1103821 aagtgctgca gctgaagaat caggagtatg tgcttgcttc acagacactg ggtgcaaaaa 1103881 catcccgtct tctatttaaa catatcgtgc caaacgcaat gggttctatt ttggtcacga 1103941 tgacactgac agttcctact gcgattttta cagaagcctt tttaagctat ttgggacttg 1104001 gtgttccggc tccgctggca agctggggaa cgatggcttc tgacggattg cctgcattga 1104061 cctattatcc gtggcgttta ttcttccctg ccggatttat ctgcattaca atgtttggtt 1104121 ttaacgttgt cggcgacgga ttaagagacg cattggatcc taagttacgt aaataaggga 1104181 gtgatacggg tgacacgcct attagaagta aaagatttag caatttcatt taaaacatat 1104241 ggcggagagg tccaggcgat ccgcggagtg aatttccatc tggataaagg ggagacgctg 1104301 gccattgttg gagaatcagg ttccggaaaa agtgtaacct ctcaagcgat tatgaagctg 1104361 attccaatgc ctccgggtta tttcaaacgc ggtgagatcc tgtttgaagg aaaggatctg 1104421 gtgccgctgt ccgaaaaaga aatgcaaaat gtccggggaa aagagatcgg catgatattc 1104481 caagatccga tgacctcttt aaatccaacg atgaaggtcg gtaaacaaat tacggaagtg 1104541 ctttttaaac acgaaaagat ctcgaaggaa gcggctaaaa aacgcgcggt tgaactgctg 1104601 gaattagtcg gtatcccaat gccggaaaag cgggtgaacc aatttccgca tgaattttca 1104661 ggcgggatga gacagagggt tgtcattgcc atggcgcttg cagcgaatcc gaaacttctg 1104721 atcgccgatg agccgacaac tgctcttgat gtaacgattc aagcgcaaat tttggaatta 1104781 atgaaggatt tgcaaaagaa aattgacacg tccatcatct ttatcacaca cgatcttggt 1104841 gttgtggcta acgttgctga ccgggtcgct gtcatgtacg cgggacagat tgtagaaact 1104901 ggtacggtag acgaaatctt ctacgacccg agacatccgt acacttgggg gcttcttgca 1104961 tccatgccga cactggaaag ttcaggagag gaagagctga ctgcaattcc gggcacgccg 1105021 cctgatttga caaacccgcc aaaaggagat gcttttgccc tgcggagctc ttacgcgatg 1105081 aaaatcgatt ttgaacagga gccgccaatg tttaaggtat ccgatactca ttatgtaaaa 1105141 tcgtggctgc ttcatcctga cgcgccaaag gtagagccgc ctgaagcggt aaaagcgaaa 1105201 atgcgtaaac tggcaaacac gtttgaaaaa cctgtcttag tgagagaagt tgaatgaatt 1105261 gactgaaaaa ctattagaaa tcaaacattt aaaacagcac tttgtcacgc cgaggggaac 1105321 ggttaaggct gtagatgatt tatcatttga tatctataaa ggtgaaacat tagggctggt 1105381 tggtgaatct ggctgcggta aatcgacaac aggccgaagc attatcaggc tgtacgaagc 1105441 aaccgatggt gaggtgctgt tcaacggcga aaatgtgcac gggagaaaat cgcggaaaaa 1105501 gctgctggaa ttcaaccgca aaatgcagat gattttccaa gacccctatg catccctgaa 1105561 tccgagaatg acagttgctg atattattgc tgaaggcctt gatattcata agctggcaaa 1105621 aacgaaaaaa gagcggatgc agcgagttca tgaactattg gaaacagtgg gattgaacaa 1105681 ggaacacgcg aaccgctatc ctcatgaatt ttccggcggc cagcgccaaa gaatcgggat 1105741 tgccagagcg cttgctgttg atccggaatt cattatcgcg gatgagccga tttccgcttt 1105801 ggatgtatcc attcaagcgc aggtcgtgaa tttaatgaaa gaactgcaaa aagaaaaagg 1105861 gctcacatac ctgtttattg cccacgattt atcgatggtc aaatacatca gtgaccgcat 1105921 tggcgtcatg tatttcggga aactggttga gcttgcgccg gcagatgagc tttatgaaaa 1105981 tccgcttcac ccatatacaa aatcattgct ttctgcgatt ccgcttcctg atccggacta 1106041 tgagagaaat cgcgttcgcc agaaatatga tccgtctgtc catcaattaa aggatgggga 1106101 aacgatggaa ttccgtgaag tcaaaccggg acattttgtg atgtgcacgg aagccgaatt 1106161 taaagctttt tcatgattca tcaatccttc aagagatttc tcttgaagga tttttttgcg 1106221 tcttcataga aagtgagaat gataacattt acaattagag gaaaaagcgg aggcgaaata 1106281 cgattcaatt tctgcataac aaaaatgttt ttgcgctatt gctgtctcaa tcttttcaat 1106341 ctttagcagg agtcctcgtc acaatcgttt taatggtccg gatctatcaa atgactgact 1106401 ccgttttttt ggcgggcctt attttatcgt tcatgtcgtt tgcgagtata gcagcaagct 1106461 tttgcgtctc tccggtgctt cgcattctcg gttttaaaaa ggtgcttgcg ggagcgaatc 1106521 tgctgagagc ggtctttatt atactgatgg catacagcgt cactcatcac ggacaggcat 1106581 tcttttggat tacgctgctg tttgtgtttt gtttttcctt cgcgggcgct ttttttcagc 1106641 cggcaagatt tgcgctgctg ccgattattg ttccaaagaa gcaatatgta aaagcgaatg 1106701 gtgtgatctc cctctcgaat caattgttct taacagcagg ctggggcctt ggaggccttc 1106761 tgacgtacgc cgtccctttt gaactcgttg tcggcgctgc catttgcctg tttgttctat 1106821 cgggagcttc catcagtgtg ctgcatgtaa atgaagaaga ggctgcagga actgctgaaa 1106881 cagcatctgt cagaagtata tggaaggatt taatgatcat ccctattgta agagacatta 1106941 ctgtaatgga catgttagaa gctttggcgg gttccgtatg gtcatctgct attctcctcg 1107001 catttactgc ggctgttttg catgaaacag aggtgtggtg ggggatgttt aacgcttcct 1107061 attttatagg cgcaattgtc ggcagtgtga ttgctattcg tttttcttct ttttttgagc 1107121 ggaatatggg ctatgccatt atgttcagct cgcttgtaat gtcggcgctg acccttttgt 1107181 tttcattttc tccagtccca tttttatgcg ctctggcttg tgctgcaatg gggccttttt 1107241 atcaggtgcg tgatatttgc caggaaacca tgctgcagga agttattccc gagcagaaac 1107301 gaatcggaat catggctgca aaaaatgcga ttttgactcc ttggtcaggc gtcacctact 1107361 ccattatggg gctagtggct gatgctgctg gtgcgaaaat agcttttatc gcggctgctg 1107421 cattatatat catgacattt ctgattgcac tggcgcagcc ccgtctggtt cattacaggc 1107481 gagaaaatcg agttcaatga gaaacacttc aaaatgaacg gagcagctgg ctccgttttg 1107541 ctgaaaaaaa aatgaaacca tggcggaagt tcgcacgtct ttatagatgt aaggctgttt 1107601 aaacaagaag aaatggggta tatctaaaag tatgaagaca acgaactcat aaggagcaaa 1107661 tcaatgaact ggtatgaaaa gcttagcgag tactttccaa ttgaagaaat gaaatcaaaa 1107721 gcgcatatgg aagctcttct gaaagagcga agcgatattt atcataaaga tgaaggcaaa 1107781 catcatattt taatgtttgc ggaattcgat tcttttatct tcgttgatta tctgtatgtg 1107841 tctaaggatg caagagggca ggggcttggc ggcaaattga tcgcgaagct gaaaaagaaa 1107901 aataagccca tattgctcga ggtggaacct gtggatgaag atgatactga tacagaaaaa 1107961 cgcctgaggt tttatcaaag agagcatttc aagcatgctc agtcaattgg gtaccggcgc 1108021 cggtcattgg ctacgaatga agtaaacaag atggagattc tgtactggtc accaaaaaca 1108081 gaatcagaag aagaaattct tgaagccatg aaacagacat atgaaaacat tcatacttat 1108141 aaagatgaga aatggtacgg agaatcgtac gaaaaaacgg atgaggtctt ggaaatcatc 1108201 gatgaagaaa aacaaaaaaa tattttcgat cagttaagct aattgagaat aagaacatat 1108261 catgaacatt aaaaatttgc tggattgaca catttttttc ttaggatact gttcacactt 1108321 acttttttat agtataatac ctgtaaagat tcctttttta gagtaatttc aatttaagaa 1108381 taaaatagat gttcatccta ctaattagag gagtgaagat gaatggttac actatacaca 1108441 tcaccaagct gtacttcatg cagaaaggcg agagcgtggc tcgaggagca cgagattcca 1108501 tttgtagaaa gaaacatttt ctctgaacct ttatcaattg atgaaataaa acaaattctt 1108561 cgaatgactg aggacggaac agatgaaatc atctcaaccc gttcaaaagt attccaaaaa 1108621 ctgaatgtga acgttgaatc tatgccgctg caagatttgt accgcttgat caacgagcat 1108681 ccaggtttgc ttcgccgtcc gatcatcatt gacgaaaaac gtttgcaggt cggatataac 1108741 gaagacgaaa tcagacgttt cctgccaaga aaagttcgct ctttccaatt aagagaagca 1108801 cagcgtttgg caaactaata gatcgtatca tcaaaagaag gctgagtcat cagccttctt 1108861 ttatttttca acctgctggt aataaatgct cgcaaggatg acaaacgcaa ccgtcaaaat 1108921 ggggaggagc gtttcgactg tgccgtgctg cgccataaaa agcgacagct ttttgtctct 1108981 gacaatcatt tctccgccag tataagcaag cagcccgctt cccgcgtaaa tcagaagcgg 1109041 tattttctct agtgcaatat ggatgagttt gctgccccaa ataataaccg gaaccgatac 1109101 acacaatcct ataacaacga gagaaaactc accgtgtgaa gctcccgcaa ctgcgatgac 1109161 gttgtccagc gacataaaga gatctgcaag cacaatcgtt cgtatcgctc tccacaggga 1109221 ggtgctgctt ttaatgtgtt tcgtgtcttt tttttcaatc agcagctgat atcctaaata 1109281 cagcaggaaa attccgccgg cgcactgcaa gaacggaatg ttcaaaagat atactgctgc 1109341 acttgttaat ccgattctca tggcaacggc aataaatgtt ccgagaataa tggcttgctg 1109401 tctttgcttg tccggcaaat gtctgctggc catggcaata acaaccgcgt tatctccgcc 1109461 gaggatcagg tcaatcccaa caatgacgag cagagaaatc agatagtcat gctccatgaa 1109521 gcggcacctc gctttcagtc cttcgcttgt actactacta tatgagacag gtcatatttt 1109581 atgatatcag ccgcctgatc tgccgttttt taggcaaagg tgcattttta tttcttttgt 1109641 gactgtttta tcataaaata gaaatacaaa ggaattcaca ctggccttgg ttaaggttaa 1109701 gatgtggacg gaatgggtaa agtgtagtaa agtacaatta atcgggagct tagatgtccc 1109761 ttcaacatct tatatagaag ggaaggttgg caaatggaaa ttgaaagaat taacgagcat 1109821 acagtaaaat tttatatgtc ttacggagat attgaagatc gcggttttga cagagaagaa 1109881 atttggtata accgtgagcg cagtgaagaa cttttctggg aagtcatgga tgaagttcat 1109941 gaagaagagg aattcgctgt ggaaggccca ctttggattc aagttcaggc actggacaaa 1110001 ggattagaaa tcatcgtcac aaaagcccag ctttccaaag acggacaaaa gctcgaactg 1110061 ccgattcctg aggataaaaa gcaagaacca gcatctgagg atcttgacgc cttgctggat 1110121 gatttccaga aagaagagca agccgtcaat caggaagaga aggagcaaaa gcttcaattt 1110181 gtcttgcgat ttggcgattt tgaggatgtt atttctctat ctaaattgaa cgttaacgga 1110241 agcaaaacga ctttatattc gtttgagaac cgatattatt tatatgtaga tttttgcaat 1110301 atgactgatg aagaggttga aaatcagcta agcatcctgc tggagtacgc aactgaatcc 1110361 tcaatcagca tacaccgtct tgaagagtac ggcaagctga ttatttcaga gcatgctcta 1110421 gaaacgataa aaaaacactt tgcatcatag caaaccgatt tccttccgga aatcggtttt 1110481 ttttatgcac gaaaatgcca ttttagagat gtgaaaaatc aaaaacatat agacaagcag 1110541 aaaatacagc gaacaggagt tgatcatctt ttccagaaag tatacttcat ctggaaagga 1110601 gagatgacaa ttgtttagtg ctgtgactga agacggccaa atgtttcacc ttctaggcgc 1110661 tcagcaaaac cagaaattaa agcggagacg gttcttctgt ccggtatgcg ggggagagct 1110721 agctgtgaag ctcggacttc aaaaagcgcc gcattttgcc cataaacaga acaagtcctg 1110781 cgccatagac atcgagccgg aaagcgccta ccacttagaa ggaaaaagac agctgtatgt 1110841 atggctgaaa acgcaacggg cttcaccaat attggagccg tatataagga caatcaacca 1110901 aagaccggac gtcatggcaa gaatcaagga gcatatgctt gctgttgaat atcaatgcgc 1110961 cactatcgct ccagatgtct ttcaaaagcg gacagagggc ttcaaacaag aaggaatcat 1111021 cccgcagtgg attatgggat acagccgctt aaaacggact gcttcgtcct tttatcagct 1111081 ttcaactttt cattggcagt ttatcaatgc aagtccatac agagaactga tatgttattg 1111141 tcctgaaagg cgttcttttc tccggctcag ccacatcatt ccattctaca caaaccattc 1111201 ttattcctca gtccaaacga tccctatcca tcgggcaggt gcaggcgatc tttttttcac 1111261 tgaaccgaaa ccctcaattc aatattcagg ctggacgaaa gcgattcacc gttttcgcca 1111321 taaaccccat cggtttaact caaaggaaac aaatcgcctt aggctgctgt tttatgagaa 1111381 acgacagacg cctttttctt ttctgccgac tgaagtgttt gttcctgtta gaaaaggggc 1111441 agtttttaag agtccggttt ttgtgtggca ggggtttctt tatttgttta tgacggatct 1111501 tggaggtaaa cgtgcgccaa ttcgtttttc agccgttttg cagcagtgca aactgcacat 1111561 tcataataag aacattgcac tcaggtccga atgcagcgaa gagtgtcttt cagaagcggt 1111621 taaacagtat attgattttt tgtgcaagaa gggattttta agggagactc agaaagaagt 1111681 atatgtgctg aatcagcctg caggaggcat acactccatg caggatctca tagaaagaga 1111741 ccgcagctgt tttatagaat gagtttgtct tatttggctc accctaagac aaaggtggtg 1111801 ggcaggctgt gaaaggcaca aaaggaaagg tttttcgtgt ttttactgct tttttggcat 1111861 tcgttctctt cattactgca tatgatttga caaaaggcag tgaaaaaccg gaagatattc 1111921 acaacacaag tttattgaga aacagctgtt ttttcaattg gcttgaatca aagaagacga 1111981 gggggatcac catggctgag gaaaaaaaag caaaccaact gcctgacaga agtgaggtaa 1112041 aggcagaaga cacatggaga cttgaggata tttttcctag tgatgaggcc tggaataaag 1112101 aatttcaagc tgtaaaagaa ttaattccga atttatctaa gtataaagga aagctggcag 1112161 attcagctga tcatttatac gaggctctta cgtatcaaga taaagtgatg gagcggctag 1112221 gtaggctgta cacatatgcg catatgcgct ctgaccagga tactgggaac tccttttacc 1112281 aggggctgaa tgacaaggcg ggaaacctgt atacacaggc cgcaagcgcg acagcttatt 1112341 tggttccgga gattttatcc atagaagaag acaaactgca gcagttcatt cttgaaaaag 1112401 aagaattgaa gctgtactct catgcgattg aggagattac aaaggaacgt ccgcatgtgc 1112461 tgagcgagaa ggaagaggcg ctgcttgctg aagcctccga ggtactgggg tcatcttcaa 1112521 atacattcag cgtgttaaat aacgcagata taacgtttcc atccattaaa gacgaagatg 1112581 ggaatgaaaa acagatcact cacggcaact ttattaattt cttggaaagt gaaaaccgtg 1112641 aagtccgcaa aaatgcgttt gacgcagtgt ataaaacgta cggacaatat aaaaacacaa 1112701 tggccacgac gctaagcggc actgtgaaaa aggacaactt ctacgcgaga gtgaaaaagt 1112761 acaagtccgc gcgtgaggct gcgctttcta acaacagtat tcctgaggaa gtatacgata 1112821 accttgttaa gacgattaat aagcatttgc cgctcctgca ccgctatatt gcgctaagaa 1112881 agaaagtgct tgagcttgat gaagtgcata tctatgacct gtatacaccg cttgtgaaag 1112941 atgctgggat gaaggtgaca tacgaggaag ccaaagatta catgctgaaa ggcctcgcac 1113001 ctttagggga agaatatgcc tctatcctaa aagaaggact ggaaaaccgc tgggtggacg 1113061 tttacgaaaa taaaggcaaa cgcaatgggg cttattcatc aggagcttac ggcacgaatc 1113121 cgtatatttt gatgaactgg cataataacg tcaataatct ctttacgctc gtgcacgagt 1113181 ttggacattc cgtacacagc tactatacga gaaagcacca gccttatcca tacggcaatt 1113241 acagcatctt tgtcgcggaa gttgcctcta cgacaaatga agcgctcctt ggcgaatatt 1113301 tgctgaacaa tttagaggat gaaaaacagc gcttatatat tctcaaccat atgcttgagg 1113361 gcttcagggg aacggtcttc agacaaacga tgttcgctga atttgaacat ctgattcata 1113421 caaaggcgca agaaggcgag ccgcttacac ctgagcttct gacaaatgtc tattacgacc 1113481 tgaataaaaa gtattttgga gacggcatgg tgattgataa ggaaatcggc cttgaatggt 1113541 cgcgtattcc gcacttctat tacaattact atgtgtatca gtatgcgaca ggttacagcg 1113601 ctgcccaagc attaagcagc cagattttga aggaaggaaa gccggcggtt gaccgttata 1113661 ttgacttcct gaaagcggga agctcacaat acccgattga tgtcctgaaa aaagcgggtg 1113721 ttgatatgac gtctccagag ccaatcgaag ccgcgtgcaa aatgtttgaa gaaaaacttg 1113781 atgaaatgga agagctgctg atgaaagtca agcagtctta aaaaagtaag cctgtgcgga 1113841 aatgacgcac aggctttttt aaaacccttt aaaggttttc cggtgattca agcggtagag 1113901 ggtaaacaaa atagacagaa acagcagagg agaggtaata taaagcggca gcatatgcat 1113961 catgcctaag atattcaagc agaaaaaaac agcaatgcac acaattgaga tcaaagtaga 1114021 catcatggcg gtcctcctcg tcctttttcc ttataaggat atgagtgaat gcacttcgtt 1114081 atgttttgtg acaaaaatat gaacattaag catagaggtt gtcaaaagtc gacatctttt 1114141 gttatcataa ggatgtgaaa ttgatcacaa acaaacatta cccctttgtt tgaccgtgaa 1114201 aaatttctcc catccccttt gttgtcgtta agacatatga aaccgcgctt atcccggcgc 1114261 ggtttcttta gtgctaaaaa tggaacgtac gtttggttat ggcataaaaa aacagcctca 1114321 agcatatgca cgcctgcggc tatttttcac atgattgata ttcatcagaa taagtgctga 1114381 gagacttcca aaacattccg tgtttggctt ccactttggc aaccttttta gcaaacgcca 1114441 gttttttcat ttctttttct acctcttcaa ggctcaggtc atatacaaga gcaatttcct 1114501 tcgaggcaac gaagcggaaa tattcaataa aacattctaa aggcggtgtt tccgacggct 1114561 tcggctcgtc gccaagcatc tcaaataaaa tttcttcata tacatcatat gagtagctgc 1114621 caggaacttt aagcccttca tcctcatgct gcgtattaaa aaacgtcagt gtcggattaa 1114681 cagaaacatc catctcggca gcaattttca tgtcacattg aagcgccttg accgcgcttt 1114741 gagaatgcag atcttttttg aattcttcaa gatcgagact tgtattttca gcaatctcca 1114801 aaagcacgtt ttcatccgta atatttttct ttgaaacaaa taggctctcc tgcatatttc 1114861 tgagaaattg catgccggct tttcgtcctt gcagttcggc tgctttaaaa gcgagagcag 1114921 ccatataagg cgatgaaagc ggctgatcct gttcgaacca gacattgccg tcacatgaca 1114981 tgccagagcg gctcgcgatc ttttcccatg cttctgcgag aagatgcttt tttcgctttt 1115041 tatttaaagc ggtaaggctt gcggaagcga taatgcgtaa ggtgaaaaaa cgtccgtatc 1115101 tgattttcag ctttttgatg acgggctcta aggaccagca ttcaggacat aaagggtcta 1115161 caaacatata aatttcaagc ggtttttttg gatgaccgtg gcaatgggcg aagtatagct 1115221 catgctgata gtttgtcaag atgatcgatc ctccgcttcc gtttgattca ccatatgcct 1115281 tgctgtcaac tccagccggc caaacaaaaa ctcacgaatt tcgccctcca gccctacatg 1115341 gtccattgcg tccttcatac agctgagcca cgcatcagct ctctcgtttg taattggaaa 1115401 gggaagatgc cttgctctga gcataggatg gccgtgttcc tcagtataaa gaggaggccc 1115461 gcctaaatac tgagttaaga attgcttctg tttcctggcg gtttctgtca aatcgcttgg 1115521 aaaaatcggc ttcagcaaag gatgagacgc gacacgctca taaaaagtat caacaagttg 1115581 cgatagaagt tcctctccaa tcgcttcata aggtgcgtta aacgattgtc ccatgttgac 1115641 tactccttta aatatggcta ataggaatca taaatcctat tgcaaaaagt aattttctgt 1115701 atttcattgt ttcatctaga tttattttag caacaaggca tcatttctac aaacaaactg 1115761 ccttttatgc gtttgatgac tcatttcggc tgacagccgg ggtttgtatt tcatatcata 1115821 tcacataaaa atcaggaatg cgtaagattt cacttcgcaa aaaaaccaga gggaaagagc 1115881 acctctggtt acgcgtaata aactgaagtt atttttttta catagttttg cgtttcttgg 1115941 aaaggaggaa tgcctccgta tcggtcaaca ttccccggtc cggcgttgta agccgctaat 1116001 gccatagaca cattgccgtc gtatttatcc agcatttgtt ttaaatattt cgttccgccc 1116061 tccacatttt gctgcggatc aagcggattg gaaacgccaa gtgagcttgc tgttgacggc 1116121 atcagctgca tgaggcccat cgcacctgct ccgctgaccg cttttgcatt aaagcctgat 1116181 tcctgtttga tgacggcgcg gatcagtttt tcatcaacgc catatttatc agcggctttt 1116241 ttaatcgcac tgtcaataga gaagtctccc gaacggatct gatttgcttc atgtttgttt 1116301 gaagctgaat ctgcaacagc tgtttcagtg ctttctgccg cttttgtgac tgaacctgaa 1116361 ttgctgctcg tatatgagtt aagcccatac gctgaaagca gtgacggcgc tgttgtattc 1116421 gcgctgttca gcatgctgag cgggcttggc gatgaagaag gtgctgattg ctgagatgtc 1116481 agaccgtttg tatattggct gagcaaagaa ctgaaacttg aaagcgggct ttccgtattc 1116541 tgagtgtccg agctgctgcg tgcattagat atggactgta atgcctgaag ctgaagtaat 1116601 gctgcccaat tcgttacatt cacgatgtca ttccacctta tatagacttt cgtttttctt 1116661 cataaaaacg cagaatttta tttttggttt cgcgctgagg aatgctgaat tgctgaagca 1116721 gcttttcgaa ggcttgtctg ccctcatgcc aatccgccgc ctcaaattca atttcatagt 1116781 cctctttatt taaatatcgg ctgtggtcta aaactattaa gcctttttct gtttcttttt 1116841 ccgcacggtt tgttgctaaa gatccaaagt attgtatggc atccgtatcg atctgaagct 1116901 tgtgcagctg gtccttcaca gggccctcgg gaactgaaaa tccagcgaga tctgatacct 1116961 ctgaaagctg ctggtgcgtt tccagaagcc ccacatcagc cggctccttt aatgtaagga 1117021 catactttcc gttttttctg cggatacgaa gcgcagcatg tttttgtttc agcgcgaagc 1117081 tgtctgtatc aaaataatga ttcttttgat ctgtaaaatc tttttctgtc agctggagtg 1117141 ccgatgctat gtttttgaat tcttgtttgg tcagcatgtt tttaaattcg atttcaatct 1117201 cttggctcat gatgctcttc ctttccgccc tgtaaatctt atttttacta ttatctcttt 1117261 agatgttagg tttatcaata tcgagctcga tatgataaaa tgaatctgta ctttgtttaa 1117321 aaaaggagag cattatgcaa aacagaatcg aaattttgaa tgcaacatta tcggatgatc 1117381 agcttcgcct tgcctgtcag acagaaggaa acgaagcgga acgcaagccg tcaggtcaaa 1117441 tgcttgttga ttctgaccac tttgcttttg tatacatact tgaattagct gattcttttg 1117501 aatatgtcat tataaaggaa catgtatggc cggaactgaa gcaggcccat gcacaaaaaa 1117561 taccggttgt tttagaggca ggagaccaaa caattgaact ggcaggcctg catgaggagc 1117621 tggaatatct tttagaaaat ataaaagata atgcaaacta tggagaagaa atggaagaaa 1117681 aagtgaaacg cgtgttttta tagaaactgg ttcggaattg ggggatgtat gatggatgac 1117741 aaacaatggg agcgtttttt agtgccgtac cgccaggctg tcgaagagtt gaaagtgaag 1117801 ctcaagggga tccgcacact atatgaatac gaggacgacc attcaccgat cgaatttgtg 1117861 accggacgcg tcaagcctgt ggcgagcata cttgaaaaag cgagacggaa aagcataccg 1117921 ctgcatgaaa ttgaaaccat gcaggacatt gctggcctta gaatcatgtg ccaatttgtc 1117981 gatgacatcc aaatcgtaaa agagatgctt tttgccagaa aagatttcac cgttgtggat 1118041 cagagggatt atattgcgga acataaagag agcggatacc gatcatacca tcttgttgtg 1118101 ctgtaccctt tgcagacggt atccggagaa aagcatgttc tcgtagaaat acagatccgt 1118161 acactggcga tgaatttttg ggcgaccatt gaacattcat tgaattataa atacagcgga 1118221 aacattcctg aaaaagtaaa actaaggctt cagcgcgctt ctgaagcggc ttcccggctt 1118281 gatgaagaga tgtcggagat caggggtgaa gtacaggaag ctcaagctgc cttttcaaga 1118341 aagaaaaaag gaagcgagca acaataggta aaggggaaga agagcatgaa atttgccgta 1118401 tcatcaaaag gagatcaagt ttctgatacg ctgaaaagca aaatacaggc gtatttattg 1118461 gattttgata tggaactgga tgaaaatgaa ccggaaatcg ttatttcagt cggaggcgac 1118521 ggaacgcttt tgtatgcttt tcacagatac agcgaccgtt tggacaaaac agcatttgtc 1118581 ggcgttcaca caggtcatct gggtttttat gccgactggg ttcctcatga aattgaaaaa 1118641 cttgttcttg ccatcgcgaa aacgccgtat catacagtcg aatatccgct tctcgaagtc 1118701 attgtgacct atcacgaaaa cgagcgggaa gaaagatact tagctttgaa tgaatgtacg 1118761 attaaaagca tcgaaggaag ccttgttgct gatgtggaaa tcaaagggca gctctttgaa 1118821 accttccggg gcgacggcct ctgcctgtca actccatcag gcagcacagc ctacaataag 1118881 gcgctgggcg gagcgattat ccatccgtct atcagggcga tccagcttgc ggaaatggct 1118941 tcaattaata accgcgtgtt ccgtacggtc gggtcacctc tgcttctccc atcccatcat 1119001 gattgcatga ttaagccgag aaacgaagtt gactttcaag tgacgattga ccatttaacc 1119061 cttctccata aggatgtaaa gtcgatccgc tgccaagttg catccgaaaa agtgcggttt 1119121 gcgagattcc gtccgtttcc attttggaaa agagtccagg attcgtttat tggaaaaggt 1119181 gaatagaaag aggacatatc gtggagcatt tttttatcag aaagaacatt acttccgctg 1119241 aggacgggat gactgtaaaa gaatatgccg gtgaactggg aatttcgaaa cgtctgctga 1119301 ccgatattaa gtttggcggg ggagacctgc agattaacgg tgagcatgtg acggtcaaat 1119361 acgttttgaa agagggagat cttcttatcg tgaagtttcc tgaggagcag gtgagcgaga 1119421 cgctgttggc agagcctgtt ccgctcgata tcctttatga ggatgaacat gtgcttgtga 1119481 taaacaagca gccgtatgtg tcatcaatcc cttcgagaga gcacccctcc ggcagcattg 1119541 ccaatggaat tattgatcat tatcaaacaa ccggagtgag ggcgacagtt catcttgtca 1119601 cccggttaga ccgggataca tcaggtatca tgcttgttgc caagcatcga tttgcccact 1119661 ccattttatc gtctgcgcaa aaaaacggcc ttgtgaaacg ccggtatgcg gcagtggttc 1119721 acgggcggat ggcacagatg gagggaacag tcgatgctcc gattggcaga catcctgaca 1119781 gtattattga acggacggta acgccagacg gccagaaggc tgttactcat ttttacgtca 1119841 catgtgcaaa tgatgacatg acctcggtgg cattgcagct tgagactgga cgaacccatc 1119901 aaattcgtgt tcatatgagc tatctcgggc acccgttgtg cggcgataca ctgtacggcg 1119961 gaacgagaca ggaaattggc cggcaggctc tgcacagcga gcatctttcg tttatccatc 1120021 cgctgacaca ggagaacatg aggtttcatg ctccactgcc tcaggacatg agcaaactga 1120081 taaaaggaga gaatcattga ttctctcctt ttttatatgg ggcgaaatct tgattcgtcg 1120141 taaggcaggg agcttggaac agagacggtt tctatttctg gaaagcgaaa gcctgtcagt 1120201 tgatttccga acacgcagcc tgtatcaatg ttgatggtgc gattgacctt ccgaggctct 1120261 ttcacaggtg tatgaccgta taccacccaa gcctttccgt tataggctgc cgcccaatca 1120321 cgcctgatgg gtctgccgtc cggatatgtt tcacccgtca cgtcaccgta aagcacaaag 1120381 tccttcactc tgcgggtata tttgccgata tcgtcagctc ttatgccagc atgggcgaca 1120441 actaattctc cattatgtaa gatgtcgtaa agcggcgctg tttcgtacag cttcataaac 1120501 tgttcgctga ctgatttttt ctcatctttg gaaagttcct caagctctgc cgctgttgtt 1120561 tcgagaccat gcatcacttt taccggattt ccttttaagt aacgatataa tttattgcaa 1120621 tggtttcccg ggacataacg cacagcgcct ttttcgtaag cgccggctac aaatcggatg 1120681 acctctatcg atttgggccc tctgtcagtt aaatctccgg caaaaacaag caccctgcct 1120741 tcttcatgga caggtactcc atttttgatt gtatagccaa gcttttggat taatgcagtc 1120801 atttcgtcat agcagccatg aatatcgctg atgatatcgt aagccatgcg gtctcctcct 1120861 taccgattgt tttatttatt atgaagcaaa gtgttgtgag tcatcacaag cttttatgtg 1120921 caaattatag aagaagaatc attttctaaa caggattaag accttatcac tttatttttc 1120981 atcatcaccc ttgttaaaat cgcgttatgt tttttaaaaa tgaggttttg ttctctgagt 1121041 gagaactagc ataaccctga cttaaaaagg aggttctgat tatggcgcat acatctgtcg 1121101 catctttagt tgttgtactt atcgttgcat ttttgacacc catccttttg catcggttta 1121161 aactcagcat cccggttgtt gttgctgaaa tcattatggg gctgataatt gggaaaagcg 1121221 gccttaattt agttgtggag ggtgacacct ggctccagac actctctatg ctcggattta 1121281 tctttttaat gtttttaagc gggcttgaaa ttgatttttc gtcgtttgag aaaggaaaga 1121341 aaaagcagtt cctgccgaat ggcaaggaag cgccgaatac gtttgctgcg gcatctgtta 1121401 ttttcgtcgg tatttttatt ttatcattgc tcttgtccta tgggttcgtc ttggccggat 1121461 ttatccaaaa tgcatttttg atgaccctga ttatttcaac gatttcatta ggcgttgtcg 1121521 ttccaacatt aaaagaagaa cggatcatga attcgaatat cgggcagatt attttgcttg 1121581 ttgctgttat tgctgatttg gccacgatga ttcttcttgc tgttttttct tctttatacg 1121641 gagaggacag cggaaacatg tggctcctga tgattctgtt tgcggccgga gtggtgcttt 1121701 actttttcgg ccgggtcttc aaacatcgct cttttgttca atccatgtca aaagggacga 1121761 tccagatcgg gacgcgtgcc atttttacgt taatcattgt actcgttgcc ctgtctgaat 1121821 cacttggggc ggaaaatatt ctcggcgctt tcttagcggg ggttcttgtt tccctgcttt 1121881 cgccaaacaa agaacttgtt cagcagctgg actcattcgg ttatgggttc ttaataccga 1121941 ttttcttcgt gatggtcggt gtgaagcttg atatttggac tcttttccag gataaaacaa 1122001 ttttaatcat gattccgctc ctgctgcttg cgctgttagt cagcaaaatc attcctgtca 1122061 tgtacttaaa gaagtggtat gataaccgaa ccattttcgc gtctggtttc ctgctgacat 1122121 caacgctttc gctcgtgatt gctgctgcaa caatcggcca gcagcttcac gtgatcagta 1122181 caaatatgtc aggagcgcta attttagtag ccgtcattgc aagtattttt acgccgatct 1122241 gttttaaaaa attatacaaa cgggaagagc agccggagga gaaaaagacg attacgttca 1122301 ttggcgccaa tcaaatgact ttgcctgtca cactcgaatt gccagaggaa gagtatgacg 1122361 tgcgtgttgt acacgtctac caagagaatg cggaggaaaa gctgtcagaa tcagtgtttg 1122421 ctgttgaaac aatttctgac tatgaacacg agacgcttga atcactcggc atttttgaaa 1122481 cggatatcct cgttgtggcg acaggaaatg aagatatgaa tgcagacatt gcattacttg 1122541 caaaagataa aggcacagaa agagtcattg caagcgtagg atcaccggag catgaagcag 1122601 ctctgaagga gcagggaatc agcatctttt ctattctgct gtcgacaaaa acgctgcttc 1122661 gcgcactgat tgaagcgcct ggcgtcatga agctgctcac gaaccaagag tcttcgctgt 1122721 atcaaattaa tatggagaac agtaaatatg atggtgtcat tttacgggaa ttccctttaa 1122781 caggtgacgt catctttgtc aggatcttca gaggtgtgga cagcatcgtt cctcatgggg 1122841 atacgaggct gaaacttgga gaccgtttaa ttgtcaccgg atctcggggg tacgtaacgg 1122901 atcttaagaa aacattggaa ggataaatct tgaccaaata aggattcgtg ttaatataga 1122961 ggtgcagaac aattcaatat gtattcgttt aaccactagg ggtgtccttc ataagggctg 1123021 agataaaagt gtgactttta gaccctcata acttgaacag gttcagacct gcgtagggaa 1123081 gtggagcggt atttgtgtta ttttactatg ccaattccaa accacttttc cttgcgggaa 1123141 agtggttttt ttattttcag agggggaatg atttgtgaag ttttcagaag aatgccgcag 1123201 tgcagccgca gaatggtggg aggggagctt tgtccatccg ttcgttcaag gaatcggtga 1123261 cggaacgctt ccgattgacc gttttaaata ctacgtactt caggattcct attatttaac 1123321 gcattttgca aaggtgcagt catttggtgc cgcttatgcg aaggatcttt atacaacggg 1123381 gcggatggca agccatgccc aaggtacata tgaggcggaa atggcgcttc atcgcgagtt 1123441 tgccgagctg ttggaaatca gcgaggaaga gcgtaaggcg tttaagccgt ctcctacggc 1123501 gtactcttat acatcccata tgtaccgttc ggttttgagc gggaatttcg cagaaatctt 1123561 agcggccctg ctgccatgct attggctcta ttacgaggtt ggtgagaaat tgctgcattg 1123621 tgatccgggg catccaattt atcagaagtg gattggcaca tatggcggtg attggtttag 1123681 acaacaggtc gaggagcaaa tcaaccgctt tgatgagctg gcggaaaaca gcacggagga 1123741 agtgcgtgcc aagatgaaag agaattttgt catctccagc tactatgaat atcaattttg 1123801 gggaatggcc tatcgaaaag aaggctggtc tgacagcgcc ataaaagagg tggaggaatg 1123861 tggagcttca cgccataacg gatgacagca agccggtaga agagctagcg agaatcatca 1123921 ttacgattca gaatgaagtt gattttattc acattcggga acgctcaaaa tcggcggcgg 1123981 atattttgaa actgctcgat cttatttttg aaggcggtat agataaacga aaattggtga 1124041 tgaacgggcg cgtggatatt gcacttttct ctactattca ccgcgtgcag ctgccaagcg 1124101 gcagcttttc accgaagcag atcagagcca gatttccaca ccttcatatc gggaggtcgg 1124161 tgcattcact ggaggaagcg gttcaagcag aaaaggaaga cgcggactac gtgctgttcg 1124221 gccatgtgtt tgaaacggat tgcaaaaagg gtcttgaagg cagaggagta tctttgctgt 1124281 cagatatcaa acagcggatt tccatcccgg ttatagccat cggggggatg acgccggaca 1124341 ggttaagaga cgtaaaacaa gcaggggcag acggcattgc tgttatgtca ggaattttct 1124401 cttccgctga acctttggaa gcagccagac gatattcccg caagctaaag gagatgcgct 1124461 atgaaaaggc attatgaagc agtggtgatt ggaggcggaa ttatcggttc cgcaattgct 1124521 tattatttgg caaaggaaaa caaaaacacc gcattgtttg aaagcggaac aatgggcggc 1124581 agaacgacaa gtgccgctgc cggaatgctg ggcgcccatg ccgaatgcga ggaacgtgac 1124641 gcgttttttg atttcgctat gcacagtcag cgtctgtaca aaggtcttgg agaagagctt 1124701 tatgcattat ccggtgtgga tatcaggcag cataacggcg gtatgtttaa gcttgcattt 1124761 tctgaagaag atgtgctgca gctgagacag atggacgatt tggactctgt cagctggtat 1124821 tcaaaagaag aggtgttaga aaaagagccg tatgcgtctg gtgacatctt tggtgcatct 1124881 tttattcagg atgatgtgca tgtggagcct tattttgttt gcaaggcata tgtgaaagca 1124941 gcaaaaatgc ttggggcgga gatttttgag catacgcccg tcctgcatgt cgaacgtgac 1125001 ggtgaagccc tgttcatcaa gacccctagc ggagacgtat gggctaatca tgttgtcgtt 1125061 gccagcgggg tgtggagcgg aatgtttttt aaacagcttg gactgaacaa tgcttttctc 1125121 cctgtaaaag gggagtgcct gtccgtttgg aatgatgata tcccgctgac aaaaacgctt 1125181 taccatgatc actgctatat cgtaccgaga aaaagcggaa gactggttgt cggcgcgaca 1125241 atgaagccgg gggactggag tgaaacaccg gatcttggcg gattggaatc tgttatgaaa 1125301 aaagcaaaaa cgatgctgcc ggctatacag aatatgaagg tggatcgttt ttgggcggga 1125361 ctccgtccgg gaacaaagga tggaaaaccg tacatcggca gacatcctga ggacagccgt 1125421 attttatttg cggctggcca tttcagaaac gggatcctgc ttgctcccgc aacgggcgct 1125481 ttgatcagtg atctcatcat gaataaagag gtcaaccaag actggctgca cgcattccga 1125541 attgatcgca aggaggcggt tcagatatga tgctacagct gaacggtaaa gacgtgaagt 1125601 ggaaaaaaga cacaggtaca attcaagacc tgctggcgtc gtatcagctt gaaaataaaa 1125661 tcgttatcgt ggaaagaaat aaagaaataa tcgggaaaga acgctatcac gaggttgagc 1125721 tttgtgatcg tgatgtcatt gaaattgtcc attttgtagg aggcggatga gcatgttaac 1125781 aattggcgga aaatcatttc aatcaagatt gctgctgggc acggggaaat acccatcgtt 1125841 tgacattcaa aaggaagcag tagctgtttc tgagtctgat attttaacat ttgctgtaag 1125901 gagaatgaac atttttgaag catctcagcc gaattttctg gaacagcttg atttatccaa 1125961 atatacgctt ttgccgaata cagcgggcgc cagtactgct gaagaagcgg ttcggattgc 1126021 aaggctggcg aaagcttcag gcctttgtga catgattaaa gttgaagtca tcggatgcag 1126081 ccgttccttg ctgcctgacc ctgttgagac attaaaagcg tctgaacagc ttcttgaaga 1126141 aggctttatt gtgctcccgt acacgtcgga tgacgttgtg ctggcgagaa agctggaaga 1126201 gctcggcgtt catgccatca tgccgggtgc atctccgatt ggatcaggac aaggaatctt 1126261 aaatcctttg aatctgtcgt ttattattga acaggcgaaa gtaccggtca tcgtggatgc 1126321 gggaatcggc tcgcctaaag atgcggcata cgcaatggag cttggagcgg atggcgtact 1126381 gctcaatacg gctgtatctg gcgctgacga tcccgtgaaa atggctcgtg ccatgaagct 1126441 cgcagtggaa gcagggcgcc tttcttatga ggcgggccga atcccgctta agcaatacgg 1126501 aacggcaagc agtccgggag aaggtcttcc tgtatgacag gcaggtattc aaggcaggag 1126561 ctgtttgctc cgatcggccc atccggccag aaaaaattga aagaagcgcg cgccgtgatt 1126621 atcggcgccg gcgcgctcgg aacagccagt gcagaaatgc tggtgagagc gggagtcggc 1126681 tctgtgaaaa ttgccgacag agattatgtt gaatggagca acctccagcg ccagcagctt 1126741 tatacagaag atgatgtcaa aaaagaaatg ccgaaagcag ccgctgcgga gcgccgtctc 1126801 cgttcgatta acagcgatgt tgatgtgacc ggccttgtca tggatgtgac agcagaaaat 1126861 atcttcgagc tgattaggga tgcatcgatt attgtggatg cggctgataa ttttgaaacc 1126921 cgcctgatcg taaatgatgc tgcggtaaag gaagggattc cttttcttta cggtgcctgt 1126981 gtagggagct acggtcttac ctttaccgtg gtgccgggtt ctactccttg cctgcattgc 1127041 ttgctcgatg cacttccgat tggcggagca acatgtgaca cagctggcat catcagtccg 1127101 gctgttttgc aggtagcagt ctttcaggta acagatgcac tgaaactgct gacgggagag 1127161 gagtgcgagc cggtgctgcg ctcctttgat ttgtggaaaa acgagcggtc agaagtgaga 1127221 gcggccagtc tcaaacatga cgcatgccca agctgcggca caaaggattt tccgtttttg 1127281 tcttatgaaa atcaaacaaa agcggctgta ttgtgcggca ggaacacggt gcagatcaga 1127341 tcatctatta cgaaagaagc ggatcttgaa gcgcttgccg gtcagctgag gcaggccggg 1127401 cttgaagtag ctgcgaaccc gtatttaatt tcctgccgct cggatgatat gaaaatggtg 1127461 ctgttccggg acggcagagc tttgatccat ggaacaaatg atattgcccg ggcaaaatcc 1127521 atttatcata aatggattgg gtaataaaag gagtgtagtg taatgagtat atataaagca 1127581 ttgacaatcg ccggatcaga ttcaggcggc ggcgcaggga tacaggctga tattaaaacc 1127641 tttcaagagc ttgatgtatt cggaatgtct gcgattacgg cggtaaccgc tcaaaatacg 1127701 cttggcgttc acggggtgca tccgctgact gtagagacgt tgagacagca aattgacgct 1127761 gttgctgagg atttgagacc ggatgcagtt aagacgggaa tgctctggaa tgccgacatg 1127821 attgaagaag tggcaagaaa aattgacgag tacggattca atcgtgtaat tgttgatccg 1127881 gttatgatcg caaagggcgg ggcatccttg ctgcgtgatg agtcagttgc caccttaaag 1127941 gagttgctca ttccaagaag ctacgcgatt acgccgaatg tcccggaagc agaaacgctg 1128001 acaggaatga caatcagctc gctggatgac cggaaaaaag cagcggagca gctcgtcaag 1128061 atgggtgcgc agcatgtcat tatcaaaggc gggcaccagc ctgaggacaa tcacattact 1128121 gaccttcttt ttgatggcag catgtttatg caaatcaccc atccttatat caatacgaag 1128181 catacgcatg gcacaggctg cacctttgct gcggctttaa cggcccaaac ggctaaagga 1128241 gacagcatcc atcaggcatt tgaggttgcg gccaactttg tccgtgaagc ggtggaaaat 1128301 acgctcggca tcggatcggg acacgggccg acaaaccatt tcgcttttaa acgaaacagc 1128361 ttaaatacaa gccgatgaga tcaccagctg atggtgatct cttttgcgtt tgctacggta 1128421 tgcgcttttc atctggacaa ggttatgata tgataggaat taagatcagg tactaatact 1128481 atgtctttat taaatatagg aggctttata catatgaatt tttcacttga aggccgtaac 1128541 attgttgtga tgggggtagc caacaaacgc agcatcgcct ggggcattgc gcgttcttta 1128601 catgaagcgg gtgcacgttt gattttcaca tacgctggtg aacgcctgga gaaatccgtt 1128661 cacgagcttg ccggaacatt agaccgcaac gattccatca tcctcccttg cgatgttaca 1128721 aacgacgcag aaatcgaaac ttgcttcgca agcattaagg agcaggtcgg tgtaatccac 1128781 ggtatcgcgc attgtatcgc gtttgccaac aaagaagagc ttgtcggcga gtacttaaac 1128841 acaaatcgtg acggcttcct tttggctcat aacatcagct catattctct gactgctgtt 1128901 gtcaaagcgg cacgtccgat gatgactgaa ggcggaagca ttgtcacttt gacgtacctt 1128961 ggcggagagc ttgtgatgcc aaactacaac gtcatgggtg tagcaaaagc ttctcttgat 1129021 gcaagtgtga aatatttagc tgctgactta ggaaaagaaa atatccgcgt caacagcatt 1129081 tctgccggcc cgatcagaac attatctgct aaaggcatca gcgatttcaa ctctatctta 1129141 aaagacatcg aagagcgtgc accgcttcgc cgcacgacaa cacctgaaga agtgggcgat 1129201 acagctgcgt tcttgttcag cgatatgtcc cgcgggatta caggtgaaaa tcttcacgtt 1129261 gattctggtt tccatatcac tgcccgctaa gcaggctgtt aatgatgcaa gggctgtctt 1129321 gctttctgta gcaggggata caaaaatctt gagcggttgg ctgttttgcc gcgcctgtta 1129381 gcagggcaag acaaatataa atgctgtttc gcccgggtca tggctacata taaaaggcgt 1129441 ctttcctcct caagagcggc ctcgtctcct tttcttgccg tttctaatga gaaatcgtgc 1129501 ggaatcgagc catctacagt gcctaacacg tagactgttt tgaattcaag gccttttgac 1129561 cggtgaatgg tcatcagctg aacgccatgt tcatccgttc tgtttttctc agcggccctc 1129621 atatggtcta cgtgggcaag aaagtcagga atcgttttga acttcttggc gacaaccttg 1129681 atgtcgcgca ggtcatcaga gcctttttcc agcttgttgc cctcattgcc ccgctttttt 1129741 aaatactcgg agaagcccat ttttccttct gcaaaggtga tggcttctac gggtttcatt 1129801 gtgcggaggc ttgcaaaaaa cggtacgatt ttcttgattt tgtccagctg gaatggcttc 1129861 agatcaggca atttggccag cgctttgatc atggtacagt cctctgtaat cgagagcgcc 1129921 ttcagcgtat tcaaagcgga ctgttttaaa aacaaggcgg gaagcaagtg tttaatcgcc 1129981 tcggtgtcat cctcattttg gctggcgtac aagtaggcga gaatctggcg gacgatccgt 1130041 ctgctgtaaa acgattggac gccgcggtca gctgtatacg gaattgacga ttgatgaagc 1130101 ctttcatata tagcacggcc tccgctgttt gtgcggtaaa gaaccgcaaa gtcttctgga 1130161 ctggctccat tttgaatttt ttctttgata tcggaaacga ccattgtggc ttcttcctct 1130221 tcatcataag gataaaacag cacagggacc tgaatgtcat cgcgggccgc ttcaagcgtt 1130281 ttggcatatc tgtttttgtt ctttttcaca acgatatcag cactagagac gatcgggtgc 1130341 gtagacctgt agttcgcagt taaatagatc gtcttcgctc ccggataatc cttttgaaaa 1130401 tcaagaatga aagacggatt gcttccgcga aacgcgtaga tggactggtc atcgtctccg 1130461 acacagcaca ggttttgctc cgggctggcg agcatttgca tgattttgta ttgaaccgga 1130521 ttaatgtcct gaaactcatc aattaagata tacgtaaacc gagattgata ttgttccaga 1130581 aggtcaggcc gctcgataaa caattcatag caggctgaag ccatgtcatc aaaatcaaat 1130641 tggctgtgtt cttttttctg gcgttcataa tgttcatata aacgataaac ttgtttttcc 1130701 cactcatctt ttagagggat gcgttcattt gggacataag tgtttttcca aaaaccgatc 1130761 tgctgcaggg cttggtcaac tggggattct ttctcatcga tgccttcttc atagagtgct 1130821 tttttgatat attgttcccg ctgccactcc attttcagca gatgctcacc gttccattta 1130881 gcagaattag agtgatacaa gatcttataa aacagactgt ggaatgttcc tgtcacaatt 1130941 cttctgactt ttgccggctg taatccgtac tggttcgcca tacgctcttt catttcagcg 1131001 acagcttttg ttgtaaaggt gacaagcagc atattttcag gcggtatgcc taagtgttcg 1131061 atcatgtggg cggcacgggc tgtcagtacc cgtgtttttc cgctccccgc acctgcaagc 1131121 acgaggagcg ggccctctgt ttccgtgaca gctttcagct gatccgtgtt taaaccgaca 1131181 gacggaaaaa ggctcgtatc gggttctatt gtttttggca caaatggtgt tcctggttta 1131241 atgcttctag gacggtgcca ttctgtaaca gctggggacg ggtcagcggc gatcgctttt 1131301 cccttgggta aacgaatgac accagattcc tgatcatctt cttttttccc ctctttagag 1131361 ggcttcggtt cgcacgcctc ctcacatgcc ggaaaatcgc ctggctggcg atggataaac 1131421 tctggcggat cggcgatgtt aagccgtaac aaaacgggct ttccgcaatg agaacaaaat 1131481 aaatgtcctt ttattccctc ttcaaagagg aattgataat gttctctcga atatgtatgt 1131541 aaatgtatga ttctatcatt cagtcgggcg catttcaaaa aggggtcctc ccaatcaaaa 1131601 ggtgttcatt acagacaatg actatcatat caaaagaaat gtgtttcaaa aagtaagttt 1131661 aagggaaaag agacagcaga ggggtgggta ttgtatgata tatgcaggtc aaattcagaa 1131721 ccagcaatac gctcaatatg ctaatagaac gattggacat aagcaggatt atgccggaac 1131781 cgaaaaaatc agctatgtcc cgtttcagcg ggtatacaaa gaactggaaa agcagcagga 1131841 gaatcaaacg gcagctgaaa gaaaagtaaa cgagatgaaa cgtaagcgct ctctttataa 1131901 gagattgcga gaaaaaggaa tggggacata tattaatcga tatgtataaa aaaccgttca 1131961 taccagagaa cggttttttt atatgcagta aaaatccgga tctcaaaaga tccggatgcg 1132021 ttcagtcctt catcatttgt aagtgcggaa tgccggcatc gaggaattct ttttcagaaa 1132081 gcacgcgata cccgtgtttc ttgtaaaacg gcacagcctg tgtttgcgcg tttaaaatga 1132141 aaccggaagc gcctccgtct gccgcggctt tttcgagcgc tttcataatg atgccgccga 1132201 caccggctga gcggtggctt ttcagtacgc aaatccgctc taacttgccg tagccgtcct 1132261 tcatgcgcca tcttccggca ccgacaggct tttcaccgtc atacacgacg atatgctctg 1132321 actcattttc aagttcgtca atttcttctt cagcaggcac gttttgttct ttgacaaaga 1132381 cttcttctct tacatagaat gcatctttca gttgttcttc attttttgcg ataactgctt 1132441 tcaaacatta ttctcctctg cctagcaaga aggtttcata tactgtccac gatccgtttt 1132501 ccaactggta gagcaagtgg aaacggtcaa cgatttcttc atgcgacact tcctgcattt 1132561 ttaattgtcc cagcacatct gaatgctcat cgtcggaaag attttggccg accgtcacat 1132621 gcggaacgaa attatattcc tgttctcctg ccaacacacc ggtgtatagc ttttcattga 1132681 gtgtttttaa ctcttccgtc ggttctgctt tgatgtaaat gacattattg acaggcgcaa 1132741 atgagctgta ttttgtcatt ttgagaacga gtgggtggga ctcttttgcg atgtttctta 1132801 aatgtgatac gagctgatcc gctttctcct ccgcgcattc aaaggatgct ctcagcgtca 1132861 aatgaggcgg gattagagag tagcttgggt catagcgctt tctgtaagag tttgcaaggt 1132921 cttggagctt ttttgatgga aataaaacga ttccgtattt catattatgt ccctcctgga 1132981 aataaagtat gatagagtgt taaagcattt ttttcagcgc cggggtgatg agcggctgcc 1133041 agtatgtcca tttgtggtct ccgtcaaatg gctcgaaatc ataatcggaa agctttttct 1133101 ccagcagctg tttcagctcc cggttcggtt ctgtaaagtc cagaatgttc ccgtctgtcg 1133161 tgtggacgtc agtttctttt gttccgattt ggtgataaat agagaggtgt ttgatatcgt 1133221 ctgactgttt tacggcttct agtacgtgtt tgtcaacata gggagactgc atgatgatgt 1133281 tgccaaacat attcggataa tcaagcgctg tcataagtga cacggttgct ccgagcgaat 1133341 caccgatcag cgttcggccg taaccgatct gataggttgg atactcatca tctgcaaaag 1133401 gaacgagctc atgggcgatg aaccgtttat aagccgaaaa ttttgaaccc tccggatgat 1133461 aagtgtttct gcgctctttt acatccttat agggaacacc gataataatg ctccggtcta 1133521 tttcgcgttt cgacagcaat tcctcaacct gtctgccgat tctccccagc ctgaaataat 1133581 cgtggccgtc ctgcgcgata atgacatggt atttataaag cggggagtag ttggacggca 1133641 gataaacaag caaggtcatt tcctcgttaa gctcttttga aaagaatttc ttttcttgca 1133701 ctgtgccgtt tttcggtgcc ataaaaacat tcctccagga catcactata ctttcttgca 1133761 ttttcaatta ttgtaccatg aattattaga aatttctctc tttaaacggt tcggcacacg 1133821 aagaaaaaag tgttgaaata aactgtgaat tgcgctaata taaaacaatc agaaaattga 1133881 aatcgatatt tcttatcgtg agaggtggag ggactggccc ttagaaacct cagcaaccgg 1133941 cttgttttgc atttgcaaag cgccaaggtg ctaaatccag caagcgtttt ttatgcttgg 1134001 aagataagaa gaagcgttaa accccttctt cttatgaaga aggggttttt attttgaaaa 1134061 gggaaggtgt cagctatatg tcacagcacg ttgaaacgaa attagctcaa attgggaacc 1134121 gtagcgatga agtcacggga acagtgagtg ctcctatcta tttatcaaca gcataccgcc 1134181 acagagggat cggagaatct accggatttg attatgtccg cacaaaaaat ccgacacgcc 1134241 agcttgttga ggacgcgatc gctaacttag aaaacggcgc gagagggctt gcctttagtt 1134301 cgggaatggc tgctatccaa acgattatgg cgctgtttaa aagcggagat gaactgatcg 1134361 tttcatcgga cctatatggc ggcacgtacc gtttatttga aaatgaatgg aaaaaatacg 1134421 gattgacttt tcattatgat gatttcagcg atgaggactg tttacgctct aagattacgc 1134481 cgaatacaaa agcggtgttt gtggaaacgc cgacaaaccc cctcatgcag gaggcggaca 1134541 ttgaacatat tgcccggatt acaaaggagc acggtcttct gctgatcgta gataatacat 1134601 tttatacacc ggtcttgcag cggccgcttg agctgggagc tgacattgtc attcacagcg 1134661 caaccaagta tttaggcggg cataacgatc tgcttgctgg acttgtcgtg gtgaaggatg 1134721 agcggctcgg agaggaaatg tttcagcatc aaaatgcaat cggcgccgtc ctgccgccat 1134781 ttgattcgtg gcttctgatg agaggaatga agacgctgag cctcagaatg cgccagcatc 1134841 aggcaaacgc gcaggagctt gcggcgtttt tagaagagca ggaagaaatt tcggatgtgc 1134901 tgtatcccgg aaaaggcggc atgctgtcct tccgtctgca aaaagaagaa tgggtcaatc 1134961 cgtttttaaa agcactgaag accatttgtt ttgcagaaag cctcggcggg gtggaaagct 1135021 ttattacata ccctgcgacc cagacgcaca tggatattcc tgaagagatc cgcatcgcaa 1135081 acggggtgtg caatcggttg ctgcgctttt ctgtcggtat tgaacatgcg gaagatttaa 1135141 aagaggatct aaaacaggca ttatgtcagg tcaaagaggg agctgtttca tttgagtaaa 1135201 cacaattgga cgctggaaac ccagctcgtg cacaatccat ttaaaacaga cggcggaacc 1135261 ggggcagtca gtgtaccgat tcagcacgcc tcgacttttc accaatcttc atttgaagag 1135321 ttcggggcat atgattacag ccgctctggc acgccgacaa gaacagctct cgaagaaaca 1135381 attgccgcac tggaaggcgg aacaagagga tttgctttca gttcaggcat ggctgccatc 1135441 tcaacagcat ttttactgct gtcacagggt gatcacgttc ttgtgacaga agatgtatac 1135501 ggcggaacct tccgtatggt gacagaggtg ctgacccggt ttggcattga gcatacgttt 1135561 gtcgacatga cggatcgtaa tgaagtggcg cggagcatca agccgaacac aaaggtcatt 1135621 tatatggaga cgccatcaaa tccgacactt gggattacgg atattaaagc agttgttcag 1135681 cttgcaaaag aaaacggctg cctgaccttt ctggacaata cattcatgac gccggcactg 1135741 cagcgtccgc ttgatctcgg cgtggatatt gtacttcaca gcgcgacaaa attcttaagc 1135801 ggacacagcg atgtgctctc aggtttggct gctgtcaaag atgaagagct tgggaagcag 1135861 ctgtataagc tacaaaacgc gttcggcgcc gtccttggcg tgcaagattg ctggcttgtc 1135921 ctgcgcggat taaaaacatt gcaggtccgt ttagagaaag cgagtcaaac agctcagcgg 1135981 cttgcggaat ttttccagaa gcacccggcg gtcaagcgcg tgtattatcc gggactggct 1136041 gatcatcccg gcgctgaaac ccataaaagc cagtcaacgg gagcgggcgc cgtgctatct 1136101 tttgagcttg aaagcaaaga ggccgttaag aagttagtcg agaatgtgtc actcccagtc 1136161 ttcgctgtca gccttggcgc cgtggaatcg attttgtcct atccggcaac gatgtctcat 1136221 gcggcaatgc ctaaggaaga gcgtgaaaaa cgcggtatca ctgatggcct gctccgtctg 1136281 agtgtcggcg tcgaacatgc agacgattta gaacacgatt tcgaacaagc gctgaaagaa 1136341 attgctccag tttcggttcg ttaaaaaaga agccggggat agtccggctt cttttattat 1136401 tgttcgtcat caggattcag aatcgcgagg acttgatgat cctcccaaac gccattaatt 1136461 tttacatttt ttcgggcgat gccttcttta tgaaatcccg ctttttctaa aacacgcatg 1136521 gacccgagat tacggggcat cacaccggct tcaatccgat gcagtttcaa ttcgtggaac 1136581 gcataatcaa caaccaatct gactgcctct gtcataatgc cctttccatt atgggctttg 1136641 tctaaaaaat acccgatgaa cgcagtttgc agcgcgccac ggatgatttg aaagagcgaa 1136701 accgtcccga ttaatctatc gtctgacgct gtaaagatgc caaaatgata ttcttcatct 1136761 ttctcaagtc tttcctgata ctcggttatt cgttttcttt gcccctcaac cgtatagtaa 1136821 tcgtctgcgc gtatcataga aaactgttcg aaaaaatctc gattttcgct ttgcagcccc 1136881 agattttctt cggcatccgt tacttctaaa ggtctaacat aaatggtttt tccttttaac 1136941 atatagtgat ctctccgttc tcatgtcagc attcctctta cattattctc agggaaatgc 1137001 aaatatcctt tttataagaa ggaagaaaac caatttccca taaaagtgcc aacatagttg 1137061 ccgattaagt agccgagcgt accgacaagc atgatcgggg cgacaagctc ccgccatccc 1137121 ttggcaattg ccatcgcagc cgcagtcgtc ggtcccccga cagtagcgtt gacggcgagc 1137181 agaatttctt caagccgcac acggaacaat tttccggcag ctaaggaaac cgctaaattg 1137241 ctaatcgcaa tgataaacac gaataataga ataagaggcg cattcgtgac gattaagcgg 1137301 agatctgcag gaatgccgat caccacaaaa aacaaataaa tcaaaaaggt tccaagctcc 1137361 tgagatccat tgagcctttc aaaaaaacgc gggaaaagaa aaatgataag aacagttaaa 1137421 gacgtaagaa ccaggtactg atcgccaagc gtaccggtca gcaggggatg agaaaaaatg 1137481 cttttaaaat aaccggaaac cttcatacta accgcaacaa gcgcgaaagc ggcaccggca 1137541 ttaaaagcga tatcctttaa ggaaatatcc ttccgtttcc aatagctttc agcactgttt 1137601 ccgctgtttc catcggcttt taccttctct tcaaacggca tggcataatg ccgctgaaac 1137661 catttgagtg caggaatgct gattaaaata aaaaacaaaa gcgccatcat aaaattatca 1137721 gccacaacgg tagccgacac atattcacca ggcgtctcaa attttgccgc catcgccgca 1137781 aagttgaccc cgccgccgat ataagaggcg ctgatcatcc caccgatttt atctaagtaa 1137841 ggaatatgct gtttgagtag aaaaaaagcc aggatactgc caagcactgt tccaacggag 1137901 ctaatcagaa aaataaacag caaacgcctg ctttccttaa aaatttgcct aacattgatc 1137961 tgaaacaata aaagtggtat cgccagcggt accacataag accacacagt gtcatacacg 1138021 ggcgactcaa caggaagcac tcctacattt gtaaacacca tagcacctgc aagggcgata 1138081 atagcgcccg acacagcaga cgcccactta aagcgctgct ccagcccgat gctcactgcc 1138141 gcccacaccg caataaaccc ccataatacc catacatcat cagaagaaat caaagaatgc 1138201 aaaaccccat cacctctatt gttagaaaat taagacatat tataatagcc ggggaacgga 1138261 acagcaagtc caaaaaaagt ttttctaaaa aagcagttga cgaatagaag gtaaggttat 1138321 ataatagaac ttgtcagaaa gataacaaca tacccagcaa cacatacata tcatgattcc 1138381 gtagctcagc tgggagagcg ctaccttgac agggtagagg tcgctggttc gagcccagtc 1138441 ggaatcatag cttaaaccct tgcgcagcaa gggtttttta ctttgcgtta ataaagccgg 1138501 ttcgtcaaat tcgtgagttg ttggcgaact gttggcgaaa ttcattgacc gcagtccaaa 1138561 aactacctcc aaacttactt gattagttca atagtaacaa acggaagatc ggatttctgt 1138621 taaatcttca ttgagaatag ccagtccaag accgtcactt cagccatgca tcttttaaat 1138681 gaaattttgt actgaaaaca tcaattgtat ttttaaattc tgctctagaa tcagcccctt 1138741 tataataatc ttgataaatt gcttggggtg atactgattc gtgatttgtg ctatggtttg 1138801 caaggcttgt agcaaaagca ggagcaacag taacgagtaa agcaagggat aatgcaaaac 1138861 cagttaaagc tttttcaatt tcattttaag cacttctttt tttaaaatac aactttatta 1138921 ttaaatggaa tacaaaaaca tccaaggtgt ttttttgtta gtaagttgag ttagggggat 1138981 tggatggcac ttagaatatt gtttctgctg atgggatgtt gattctggat atatttccaa 1139041 cacgattaca ggccggacat gaaagcgaac cttgctttga tcggggcaat catttcattt 1139101 acggctgcgg tttactttaa agatattgat gtattgagag aagagggaaa acaaatgaac 1139161 ggaatttctg agcgttggaa cacgtttaaa ttacaaaaat cccctgaacc actctagatc 1139221 aggggattgc tttcccaaca gcttattaag tagcggaagg catgatcaac gatttagtat 1139281 caatttatta attgcgaata ctagaaacat accgttttcc gccttcctta gaagtaacat 1139341 attctcgagg aacattaagt ctattggtag aatgataact tacataaagt ttcatatttg 1139401 ctcggctcgt tacgatagcc gtatgatcca tccaaccatc agcatagcga agacctattt 1139461 tattatggta atcatagtga tatacatctc caagctttac atttgaatat gtatcagaaa 1139521 cagtcttcat ttttattccg ccagctttta aaatgtatga tctaaaggct cctgcattaa 1139581 cccaagcatc tgtatagggt ttccattctt taaagtacgg cattcttcca gctcttaatg 1139641 cttgggaaac aaagttagta caatctttgt ctttataata tttatagttt ttatttggtt 1139701 ttaaggcata tttttctgca tatttcattg cagcgtaacc actatatcct ttaacagatg 1139761 ttgcagtcac agttagttga ttagagttag cagcattgaa gttcatactt actggtttat 1139821 cttcactttt cacttcttct ttatcatcat ttttcacttc ttgcttatat ttttttaaaa 1139881 attcatctaa tttaacatcc gaagaatatt cttcatcatt ttcatattgt agagttgaag 1139941 aagaattatt taattgtgtt acatttagtt gcttagaaga attactcaat ggtattacat 1140001 ttagttgatt agaagaattt ttaacttgag agaaacttag attagaagta tttgttgatt 1140061 gagaactttg tttattagaa gttgttttgg gaatttcaag tttaatatta tcgcccagag 1140121 atgttgttac tttttcaaca ccaaaaacaa agtttcgagt aatataagct tcaacaatta 1140181 gcttattgtt tttttcagaa gtcttaacat cgtctatatc gtatgtaaac tcgtggaatt 1140241 tttgtttgtc cactttactt aacgcagaat acagtaagac tccttcgtcg gaatcagtca 1140301 atttagactc tttaggatgc gctaaaggag tgttgtgttc aaaatcatat ttttgttgtt 1140361 ctaacatatc cttaactttt tcgtaaccaa tctcgttggt aattgaaaca ttttctttag 1140421 tctctttatt agtagtggct gcaaaaactt catttgttga cactaatggt gacaatgata 1140481 gacataaaac tagtgaagca agtaattctt ttttcatacg aaacctccaa taaaatctaa 1140541 atataagtaa tatttatcat ttacaccaat tgaaatatgg cataaaatac atgtaataat 1140601 ataacataaa aataaataca taaaaaggta tcggaggaaa aaatgaaaaa gaaaactaaa 1140661 attatacttt ctctcttggc agcacttatt gttatattga tagtacttcc agttctatct 1140721 cctgttgtct ttacagcttc ttcggaaaaa ggagcaatca gacacgaaat ttataaaaga 1140781 ggatatccct accaaagcta ctttgcagtt ctccagaaaa gagaaggaga caatgaatct 1140841 gggaatcttt attatgtaaa ttggctagat tggaaagatg aaacagggca aactcctcac 1140901 ttatgctatt cgaaaaaatc atcagatggt gaatacgaag taagttgtgg cacagggccg 1140961 taaaaataaa ttttaaaatt gaataagtcc aagacggaaa gcctgcggac actgatcgtt 1141021 ttacagagaa atttgtgctt cgatcggtgt ccgttttttt tcgcaactaa ccagatgtct 1141081 atcgcgatta ctagctatga aaggagtaat tagacatgaa acagtccaaa aagaaaccat 1141141 cacagaagca acatgagcgc ttagatcgtt tctggcaaca aatgatgaac actaacatgc 1141201 aaacactcag acgtggcaaa ggcggcgctt ataaacgcag aaagtaaaaa gggagtttga 1141261 ggatgatgaa aaacggattc gcttataaaa acggaaagct tgtgaatatc ttttgcggca 1141321 aagaagagct ctataacgag ttgaaagcct tcttggtcaa aaccttcagt atcaacgtga 1141381 aagaggtatc gaggccctca atatatcgca gaacaaaaag caaacaactg gaatgacact 1141441 tactctattt aactatcagg agggaaagca ctatgacaga tcaaatgatt gcatgggaga 1141501 ttgaggaatg gattcgtgat tataaattca tgctgcggga gatcaaaagg ctcaaccgtg 1141561 tattaaacaa agtggatttt attagcacaa agctcactgc aacatacggg gaggaagcgg 1141621 gcatgccaag gggatcagca ggcgtcagtc aggcagaatt gcggcagatg gaccgaagag 1141681 aaaggcggct tcacaaatat gaatctattg tgcattacct ggacaatgca atggaacaca 1141741 ttgaagaaga aaagcaccga atcgtttacg attgcatgat ggaaggcatg agctacactg 1141801 ctattgcaaa ccaccttgat tgctcccggg ataccatcag aaagatcaaa acagccataa 1141861 tcggcaacat cgtcaataaa gtcaaagaag ccaactttct gcaatatttg aattcgttta 1141921 aatcggcggt gtaaaatggg gggcaggatc ggcgcggcgg attattcctg cgtcaccacc 1141981 aatttcatac aatgagtaaa acctcccagt ggtaagcgag gatcaactca actgggaggt 1142041 cttacatagt gaatcggtga taaaacagca gcagtattgc gtacatgtta atatccccga 1142101 caaaatatgt ttttttcaac agattcgttc gacaaatttt gcaaattgtt aatcgataac 1142161 ttttcattcc cgatattaaa aatgggagtg aattgtaaaa tgaaaaaaca gaaaaataat 1142221 aaaaagaaga atattgaaaa gcgaaatatt gaaaagcgaa atattgaaga gaagaataat 1142281 gaggacttag aagaactgga aaatgcgatt tatacttatc acaaaaagga gctacttgct 1142341 ttctttcttg aaaaaactcg aattggtcat gataaggaag aatacaaaag gttccaatct 1142401 cttctttata agttggatat tgaatgttta gaatttgcta tatcgagatt ttctcatata 1142461 gatattatcc atgatcattc aaaatatgtt ccagccttta tccctttatt tgcagcatat 1142521 ctcaccatgt tctttaattt ttatgaaaaa cattggggag ctttatcttt tgctgctggt 1142581 acaattgctg ctattgtttg gataattgca gtagaaagaa aacatagaaa tcaagcaatt 1142641 tctattatga aaatatttga acaagtcaaa gagagaaaag tgaaagacag atctaaagac 1142701 tgaaaggaga aaatatgaat aaggataaat taaggtatgc aatcttaaaa gaaatttttg 1142761 aaggtaatac ccctttgtca gaaaacgata ttggagttac tgaagatcaa tttgatgatg 1142821 ctgtgaactt tttaaaacgc gaagggtata tcattggggt ccattattca gatgatagac 1142881 ctcatttata caaattagga cctgaactga cagagaaagg tgaaaactac ttgaaagaga 1142941 atggaacatg gtctaaggcc tataagacca ttaaagagat taaagattgg attaaataat 1143001 aagagcatcc tgcggggtgc tttttttgtt ccctgtaaac tgcttccggt aagtctcagg 1143061 atagacaatt ggcggttaac ggcttgagca cggtggtggt ttagagggaa tatcttttcc 1143121 aaaacaacac gaatcagaag ggggcggcgg tgaatgtaga tggccgaaaa gcacattcag 1143181 gcgtataagg attacgtcaa aggcatgaaa tacaaggacc ttgccgagaa atacggggtg 1143241 tcagtgaaca ccattaaatc gtggaagcag cggcatggtt gggaaaggaa aaagggtgca 1143301 cccattgaaa aaagtgtgca cacaaaaaaa ggcgggcaac cgggcaacaa aaatgcatta 1143361 gggaacaatg gcggcgcacc acagaagaat caaaatgctg tgactcacgg ctttttctct 1143421 aaattcttgc cagaagagac gcttgaaatc atggaagaga ttcaggagcg ttcgccagct 1143481 gatatgatat gggatcagat acagattcaa tatgcggcca ttcttcgggc gcaaaagatc 1143541 atgttcgttt ctgataagga agaaatgatc aaagagctga aaaagaaaag gtccctcata 1143601 tctgaggtca gcgaaattga agatgggctt gtcattagtt ttagtacgtg gtttcgctac 1143661 agactttaca gtgaaacaaa cacctaacac atttcacatt gcttcagatt gccttcaaac 1143721 ttgataatat aacttctaaa ccttcctata aaatgaaggt tttttatttg atttcaattt 1143781 ttaaatcctt tacatacagc gattgattaa ctcgagcaat caatgtcgca gttatattta 1143841 tttttcaaga aaatgttata atgaaaagcc ataaaatgat gggaggggga atttcgatgc 1143901 attacataac ggcatgttta aaaatcatca gtgataaaga ccttaatgag ataatgaagg 1143961 aattcaaaaa acttgaggaa gaaacgaaca aagaagaggg ttgtattaca ttccatgctt 1144021 atccgcttga gccatcagaa cgtaaaataa tgctttggga gatttgggaa aacgaagaag 1144081 ctgtgaaaat ccatttcaca aaaaaacaca caatagacgt tcaaaaacaa gaattaacgg 1144141 aagtagaatg gttaatgaaa agcaatgtga atgattgaaa ggctctttaa aaagagacat 1144201 tcaatgactt agtatcagcc acttgtgact aagtagtaaa ttgttgtcca actcttattt 1144261 tttctattta atattttttg agacgaaaat gtttttttaa gctgatttta aaatgtattc 1144321 aaagtcagct ctgtttgatt taatggatta tattatttgg atagcttgtt accatcataa 1144381 tggagatact ccttataaat tggaggttaa aataatgagt cattctcaag aaaaaattgc 1144441 actaattaca ggagcaagca gtcaagggga tattggtacg gctatttgtc gtaagttagc 1144501 ctcacagggt atacatatct tctttactca ctggaattct gatacggcct ggatagaaga 1144561 atttcaacaa gaaattttac gtatgggtgt ccgctgtgag gcaatgaaaa ttgatttatc 1144621 agatgcacat gctgcattca caatacatga aaaaatttca gataaattag gatatccttc 1144681 catccttatt aataatgcag ctcattccgc aagtgataat tatgtatcgt tagatgctaa 1144741 atcacttgat gagcattatg cggttaatat gagatcgaat tttcttcttt gtgttgaatt 1144801 cgcccgtcgg tttaaaaaat ctaatttaat atcaggaaga atcatcaata tgacatcagg 1144861 gcaggattta ggtcctttgc ctggggagtt agcgtatgca gcaactaaag gagctatttc 1144921 tgcatttact aggtcgttat cacaagaact tgcaccattg ggcatcactg ttaacgccgt 1144981 aaacccaggt ccaacagatt ctacatggat gacagatgaa ataagaaatt ttctttcacc 1145041 taaatttcca atggggcgta ttggcacacc agatgatgca gcacgaatga ttgcctttct 1145101 tgcaagtgat gaggctgaat ggataactgg acaaattatt cattcagaag gtggatttat 1145161 tcggggctaa gctaatgaaa cacggtatac accaatgtat gatgtattcc caaaactaaa 1145221 tctaaacttg aagcgaaaat aaggtccctt ctctttttag agggggacct tattttattc 1145281 atgcatgttt tgcatccaga aaatctggcg gataaagatt aataaaccgt tacatatact 1145341 tttccgaata ctgcagtacc tttaaacaaa gtaatcgtgg ctttcccttt tgatttagcc 1145401 gtcactaaac cattttgatc gacttcagca actttttggt tatcagtcca ataacgagta 1145461 gctgaattat ttttaacaga ataggtttct ccaactttta gaggtaaatt atagtcttga 1145521 atcttgataa catgtgtagg tgaaatagaa atgttcttta cttcagtagg tgtggagttt 1145581 atttcatgag ctgaagctac cccgctgacc gacagagcta acgcagaaat cgataaagca 1145641 gaaacaaccg tttttttgaa attcattttg aaacactcct ttaaagtttt ttgtcttgca 1145701 ctataacaat tcaataaaag taattatttt ccttgtaaat aaatgttaat aatatgtgaa 1145761 cgatcaattg atttgagcta agaatattgt gtgccctgca cagagtttgt atttatgatg 1145821 gaaaattgct gagagagaat ggccatcctt aaaatgttaa tagcacacat ttgatgggta 1145881 ttagtttgtt gagcgtgtgg aaattttgtt acctgcactt tatccccgaa gataccaaat 1145941 cacttttctt catcatgttc ttactttcgt actcatacat tagaaaatct tcgttctaaa 1146001 taggtgaaga attggagtat ttttatgaat ttctgctgaa tatacattac atagcaaact 1146061 caaagagtat aaaaatcgct tttttccgga agcttcggta aaaaacgaaa cttttgtctc 1146121 tatgattttg ttttataatg taaacggttt cttatatagt atacttatac tatcaatttg 1146181 ctcaagtaga tactgacagg aaggatagaa aaacagatgg aatacataaa tacaagacaa 1146241 aaagagattt tgtatctgtt gttatctgaa cctgatgact atttagttgt gcaagatttc 1146301 gcagataggg tacagtgttc tgaaaaaaca atccggaatg atttgaaagt gatcgaggat 1146361 tatctcaatg agcattctca tgcacagctt attcgaaaac cagggttggg cgtttattta 1146421 catatagaag aacaggaaag gacctggcta agccaacaat tacatactga acatttttct 1146481 tctaggcagc ggagcgataa ggaaagaatg ctgcacattg cttatgactt attaatgaat 1146541 ccgaagcctg tttccgcaaa agacattgcc gctcggcatt ttgtcaatcg atcttccatt 1146601 aaaaaggatt tatacgcagt agaagagtgg ctgaagcgtt ttgatctcac actggtttct 1146661 aggcagcggc ttggattaaa ggttgaaggg aacgaaagaa ataaaagaaa ggcattggca 1146721 agaatatctg atttgattca caatacagcg tttaccagcc aatttattaa aagtaagttt 1146781 ttacattatg aagtagactt tgtgacgaaa gaaatcaaat cactacaaaa aaagcattcc 1146841 ctctatttca cagacgaaac gtttgaaagt ttgttgctgc atacattgtt aatggtccgc 1146901 cgcatcaaaa tgaagcagcc gatttcattg tccccaaaag aaatggcggc agtaaaaaag 1146961 aagaaagaat atcaatggac atttgcttgt ttacagcggc ttgaaccggt ttttgcaatt 1147021 cgcttccctg aagaagaagc cgtgtactta acattacata tattgggcgg taaggttcgt 1147081 tatccattgc agacagaaga gaaccttgaa aatgctgtgc ttcctaaggt tgtagggcat 1147141 ttaatcaatc gtgtttcaga gctgaaaatg atggattttc acaaggatca ggatttgatc 1147201 aatggtttga acattcatct caatactgtg ctacaacggc tgagctacga tctttctgta 1147261 gcaaatccta tgctcaatga catcaaaaag atgtaccctt atttgttcca cctcatcatt 1147321 gatgttttgg aagacatcaa tcaaactttt gatcttcata ttcctgagga agaggcagca 1147381 tatttgacat tgcattttca ggcagcgatc gaacggatgc agggcagcag cgagacacat 1147441 aaaaaggcgg ttatcgtctg ccacatgggg attgggatgt cacaattgct gcggacaaaa 1147501 attgaacgga aatatcacca aatcgctgta atggcttgta ttgcaaaggc cgatttaaag 1147561 gattatatca aaaagcatga ggatattgat cttgtcatat ccaccattgc gctggagaat 1147621 ataacggttc cccatattgt tgtgtctccg cttttagagc ctggcgaaga gaagaaatta 1147681 agtgcgttta tacgtcagct gggcgaatca caccgccaaa aacaaaaaac gtttcagatg 1147741 ctgaacaata cgactccttt tttggttttt ttgcagcagg aggcggagca tcgctacaag 1147801 ttaatcgaac agctggcgac agctttgttt gagaaaggct atgttgataa ggactatgcg 1147861 gttcatgcgg tgatgaggga aaaaatgtcg gctacaaata ttgggtcagg cattgccatt 1147921 cctcatgcaa acgctaaatt tattaaacaa tcagcaatcg cgattgccac attaaaggag 1147981 ccgcttgaat ggggaaatga aaaagtttcg ctcgttttta tgctggctgt caaacacgag 1148041 gatcaaacta tgacaaagca gctgtttagc gagctttcat atcttagcga gcagccggcc 1148101 ttcgtccaga agctgacgaa agaaaccaat gtcatgacat ttttatctca tttggattat 1148161 taaaagcagg gattattcct tgcttttttt gttcatggca gggcttgaga aataaatttg 1148221 cgagtgaaga cgcctattct ccagcaatga tctaaataaa ataagagttt aatagttgga 1148281 gaagaaatgt tacactcttt tctgtatatg gtaaagaatg aaaaaacacg attcggttgg 1148341 tagtccggat gcatgattga gaatgtcagt aaccttcccc tcctcgggat gtccatcatt 1148401 ctttaatatc ttttatgagg agggaatcgt tatgaaatta acgatttact acgatggtca 1148461 gttttgggta ggcgttgttg aagttgtgga caatggaaag ctaagagcct ttcgtcatct 1148521 ttttggcaaa gagccgaggg attctgaagt attagagttt gttcataacc aacttttgaa 1148581 tatgatggcc caagctgagc aggaaggagt gcgtttacaa ggcaggcgtc aaaaaaagat 1148641 caatccaaaa agattgcagc gccaggtttc aaaagagttg aaaaacgccg gagtaacttc 1148701 taaagctcaa gaggcgataa agctagagct tgaagcaaga aagcaaaaga aaaaacaaat 1148761 aatgaaagaa caacgagaac atgtaaaaga gcaaaggtat atgctcaaaa agcaaaaagc 1148821 gaaaaagaag cacagaggta aataatccaa acaaaagcag gcgcagtgcc tgcttttgta 1148881 attaaggact ctactttgta acatatatcc aatgtttata ctccgctgat ttatgattca 1148941 atataaaccc taacttctcc aaggtttttt gtgagcctag attatcatgt tcgcatcttg 1149001 cggtgatccg ggatactgtt tctcggctta atgcccagtt tattagtttt tgggcggctt 1149061 ccacacaata acctttgcgg cgatgacttt tatttgttgc aaaaccgatt tcaatcatgc 1149121 cattttcgtc tgggtcacct aaaaatccag ttcccccaac aatttcataa ttgtccttct 1149181 ttacaataat ccatgaatca aatccttttg ttccattgtt tttgactaaa atctcgcgga 1149241 aataaggtat cgcttcaaaa aaatcagaat ttggccattc accatttgtt tcatagccta 1149301 attctttgat agcctgatga tcttgtttag acgcggcgtc aagaagggga atatcaatcg 1149361 tttgtaatcg taatcgattc gtttcaagga gaaccatata tttaatcctc ttttcttttt 1149421 actgggaata atgataacat ataacaattt tctctggtac cttggcagta gagaaagatg 1149481 aaaaaattga gggggattga aagagtgaca ggtgagagtt tgcccagacc aaaaacgggt 1149541 aggaaaatgc tgatgttaat gtgtccctac ccgtttttct gttcctgaat gcagggtttc 1149601 tgataacatg ttgtgctacc ttttcgcaat caaataaagc gatatggctc tttgggtttg 1149661 cacaggatta tgaatgataa tgacccattg gtttcttcgt cttggaaagc ttgctaccgc 1149721 atacaatgga gcagtatcgc gcggagtgaa cccaccattt atcacgttga tatctcttcc 1149781 ttcaagatga caaactaagt attcacctgg attgatgacc tgttggttcg tccatgcgta 1149841 agaataaaag ccgtctccaa gatcttcggt ggaagatggg gggacaaagc catctacagt 1149901 caatgtgatt tctcttcttc gctgtctttc tgaaaagtct ggacttcttt gagggttatg 1149961 agtatgtgaa aagtaaggaa ttaacgcagg gccataaaag taatgataca aagcaaccac 1150021 tcctttattt tccattcata caaattgtat gtgggagtta tttgttcatt cctgttttgt 1150081 tccatgtaga ctaataatgg gctataggcg tccaaggaaa tcaatttgtc cttccgttga 1150141 ttcaatgcta gtaaccttga aaatgcaggt taggatgata gaatttacat attactgcaa 1150201 gaagttagac atacatcatt ttgatagtgg gtgaaaacaa tggcgaaaaa aatggcaaaa 1150261 acaaatgcgg ttcgtctgat agaacagcag aacatctctt atgaggtatt agggtataaa 1150321 acagacggcc agccggtaga tggcatctct gttgcggaaa aaatcggtta ttctttgaaa 1150381 tatgtatata aaacgttggt tgcagcagca ggaacaaatc attattatgt ctttgttgta 1150441 cccgttgcag aagagttaga tgtaaaaaag gcagcaaagg tgacagggga aaagaaaata 1150501 gaaatgattg caatgaagga gctgttagcg gtaactggct atcttcgcgg cggctgctcg 1150561 ccaattggca tgaaaaaatt gttcccgacc tatattgatg catctgcaga aacgcttgat 1150621 tttattattg tcagtgcagg gaaaatcggt atgcagctaa agttggcgcc acaagattta 1150681 gccagatcat gtgatgccgc atttgcagaa attgtataga tgcagatata ggggaacgaa 1150741 aaagcttagt catatcgatt aagctttttc cgcatccctt tcaaatatga tttcaaaata 1150801 agcagctgcc ccatacccat ctatactggg agcgaaaatc tgaacgaatc tccagcctct 1150861 tttcgcataa tcatggatga tttgctggta gtcttcttta ggccttcttc tcatcgtact 1150921 cagctcaact cttacgaatt catattcttt catcgtttga tccctcctat taaggtatac 1150981 gtaaaatgga gcgagaagtt ccgaaaacct aggttaaggt cggaaagtat atttcactca 1151041 ctaaacaaat ccatttatgc ctgatgcctg catgcatctg ggaagagtta aggggctata 1151101 aaaacgaatt ttaccgggtc agcagtccaa atgaatctct tgcttattgc atttgactga 1151161 gtatataagt aaaaaaagag cggccagaac atataagaag gagatgatca ttaacgcact 1151221 cataacaggg tagtgtttag cggagtagat gaaaaaatca agctgtgaaa tttgtttggg 1151281 gctgctgacg gcatcaattc cattaagcag ttttgagagt ttagcagtat agttccaatc 1151341 aaatcgatct gaaacaagct cgcttccttg ataccaatta acagcagcta aaaacagaaa 1151401 taccataata gaaaatccaa gctgaacaac taaaaatatt cccttcactt ttgtatgacc 1151461 tccaaatcta tgaatatggg aaaatcaaac aatatattac caccgtatgg gttattcttg 1151521 caatttcact tccatacaac tcaaacgcaa gtctattttt ttgtttgttt ttggcttata 1151581 atacctgatg atggaaaaag agtgcgggtt tatagattag agaaacaaat gtatttctta 1151641 gcatttttta tttgtggaga gagtatagaa gcattcgatt agatctgctt tttcacagaa 1151701 acggttttca tctgtttgcc tgagctttac aattggctgg caaaaaaaca atgatttctt 1151761 tcaatcaaaa catgcaacga tgcgacacat tttatatctt gatgacttat ttcattgcct 1151821 ttaagtcatc ctatcgagaa agcgatggta ttttatgaac aaagaaaccc taaaaaacat 1151881 actcatgatt ttttcaatat gcgcaacact ccgagaaacc gatggtatgc gcatagctga 1151941 tagctggatt ttgagtgaga ttatacgatt tttgatttgc atggttgtgt tttttgccat 1152001 gacatttcta ttagatgctg tttttccaaa caaaaaagag tcacattaat gtgtggctct 1152061 ttttgcatca tctgatcaga aacatcataa atgaatcgat catcatgatg aagaacagca 1152121 agcaaaaata aataagcgag tagacaaaca tatcctttgc ccacttcacg tcatcgtctg 1152181 ttttgaatcc tttgatgctt tttttgatcc atatgcctcc gagaaccaag gcggctaaga 1152241 aataaaatgg gcttatatgg ccggtgccga gagagaaagg aaataatagc gtgaccggca 1152301 ccaggacggc aatatattgc atcattttta tttttgttac atgattgcct ttgactactg 1152361 gcaagagcgg aacgccagca gcgcgatatt cctctttgcg tcttatccca atcgcccaaa 1152421 aatgcggcgg ctgccacaga aacataatcg tgtacaacag cactgctgtc atactgaagt 1152481 caccggttac ggcacaatac cccatcaatg gcggcgcagc tcctgggaag ctcccgacaa 1152541 atgtgctcca cacagacgtt cgtttcaccc ataccgtata gatgatcgca taaaaaataa 1152601 aggcggccag tccgagaaag gccgttaatg gattgaggga ataaagcatg gcaagacctg 1152661 cgattcctaa aacagagcca tatgttaaga tcatggctgg cggcattttc cctgtgaccg 1152721 aggccctgct gcgagttcgt gccatttttg cgtccatatg ccgatcaaaa tagttgttat 1152781 agacagtgcc ggaagccatc acaaacgcgg ttcccaacat tgctgttacc attgtcatca 1152841 aaaaagccaa gccggttaac gttttttctg cgcttgcaaa cgcgatccaa aacccgccga 1152901 aggctgctat cgagtttgat atgataatgc ccggctttgc aagtttgata aaatcgtaaa 1152961 tggttacccg gttcgaagct tttatgtatt ttgtttcaga tatggctgca gaatctcttg 1153021 tattctccaa aaatagacgc ctcccccaaa actgcatgct tttgttatcg taacaagagg 1153081 gggacagaat cacaattatt tcccatattt gtcatgatat tgtcattttt aaaacaaaaa 1153141 aatggggagc tggactgccc ccattttgat atgtggcgac tagtaaccgt aacctccccc 1153201 atatcctccg ccataacctc cgccgtaacc gtaccaaggg tagtaaggcg gtcgcgggcg 1153261 cgggtagtaa taaggcgggc gcggataaaa cgggtagaac ggataatacg gtcttggata 1153321 ataataaggc ggataaaatg gcggtctcgg acgcggataa taataaggct gtctttcatc 1153381 ataaggggta atttgttcaa atgactgttc attcaaaggg taatccaaga ggaaaacctc 1153441 cctagctttt tttattcctt ttaccatatt cctgatgctt aagttgggtg tatgtacatt 1153501 catgaaattc ggtttttttt atgatgaaat tccttaaaaa ggattgacat gaacttctaa 1153561 atctcatagt attacaaatg tgaaataaat gttactacaa tgttacaaaa acatttctaa 1153621 atagatacag ttccaactga tgaagagtaa atcgaaatgg ctacgaaaga aggagttttt 1153681 gttgttggca aaaagaatca aatggtttca tgtattaata gcagttgtat gtgtggtggg 1153741 ccttatcggc tttttccata atcattcatt gaaaaaagaa acggtcatga ataaagtaag 1153801 aactgattct caatatggga atgttgagat cgcaacgctt gtgaatgacg ggaaaacttt 1153861 taattacgcg gtaaactatc ctgttttcaa aaatgaaaaa atggattcgg cattaaaaag 1153921 attcgcagaa aaagaggttc gtcaatttca aaaggaaaca aaggacgttg accaagagca 1153981 tacgacaaaa cgcaacgaat taaatgttga ttataaaatt gtccattatg ccaaacagac 1154041 agtggcgatt gtatttaatg aatataaata catcggcggg gcacacgggc aaaccgtgaa 1154101 aaaaacgttt aactatgatt ttagtaaaca agcgtttctt tccattgatg atattttcaa 1154161 agaggacgct gactacttac ataagctttc gttaatcgct tatcacgagc tgaaaaagaa 1154221 taaggacatt gccgcggacg atgcactgtt aaaggaaggg acggctccga aaaaagaaaa 1154281 tttcagccgc tttgccatca aggaggatta tatcgaactt tactttgaca catatcaggt 1154341 tgcagcaggc tatcttggag agcaatcgat tgccattaag aaaagtcttt tgaaagacat 1154401 tctgaaagaa caatatattg ataaagcaaa aaataaaaat aaaatcaaag aacaaaagcc 1154461 gaagcatgaa gtgatttctt tacccaaaga ggaaacagtt gatccaaatc aaaaagtcat 1154521 tgcgcttact ttcgacgacg gcccgaatcc tgcgacaaca aatcagattc tagactcctt 1154581 gaagaaatat aagggtcatg ccacgttttt tgttttgggg agcagagttc aatattatcc 1154641 ggaaacgcta ataagaatgc tgaaagaagg aaatgaggtt gggaaccatt catggagcca 1154701 tccgcttctc acaaggcttt cagtgaaaga agcgttaaag cagatcaatg atacgcaaga 1154761 catcattgaa aaaataagcg gatatcgtcc gacgcttgta agacccccat acggcggcat 1154821 taatgatgaa ctgcggagtc aaatgaaaat ggatgttgcg ttatgggatg ttgacccgga 1154881 agattggaaa gaccgtaaca aaaaaacaat tgttgaccgt gtcatgaatc aggcgggaga 1154941 tggaagaacc attttgattc acgatattta ccgcacctct gctgatgcgg ccgatgaaat 1155001 tataaaaaag ctcaccgatc aaggctatca attggtgaca gtttctcagc ttgaagaggt 1155061 taaaaaacaa agagaagcga aataaattag aaaaggctgt ccgtacggac agcctttttt 1155121 ctatttaata agagcctgtg gtggcccaaa catttaagtt tggtcctgaa tacttgccga 1155181 aagcgtaaga agtccttgga tctaaatcat ataccatcgg tgtatagcaa gacttttggc 1155241 cggccaccgc ttttccattg ccgcctgcag aatcacaatt atatcttttt ccgtctgtgt 1155301 tccgggtaat ctccgcattt gcttcatagc cagacgtcaa tgtattattc atcgtgattt 1155361 ttgcccaagc cgttttacat gtactgctga atttaagctc gactactccg atgacttgat 1155421 tgctggcatt cactaagttt gaggattttt ttgtagagcc gctggacgca caatcattgt 1155481 aataagggct ttttccatcg taggcatggg tttccgcctt ggcgggtgca cctttgacgg 1155541 caaaaacaaa tactactgcg aataacacca atgaagcctt cataaacagt cttttcaatt 1155601 tatgacctcc ttaatatggc aaacaataaa tcatatggag gaacaatcaa aacatgcatg 1155661 cttttttgtg aacaataaag gcggccggga ggatggagtt cttggccgcc tctggtatga 1155721 ggttatgctt ttacatcaat ggtttgtccg agagttggat gttgaatcat ctttaaggtt 1155781 tgatcggcat tttgctgggc ggtgtccagc ctttttttcg ttaaagcaat atttacattc 1155841 tgggcaaggg atgcttgatg catcgcaacc gataaagcag gaatatccat ggttccacct 1155901 cctatgcctt acctatcggc gggtttgtat gattttacag tgaaaaatgg cttaatttct 1155961 cttgttgacc cttacgctgc ggcatatcgt atgtttttga caaggaggga atcaggatga 1156021 atctagtaat ggaaaagacc tttgagcaat acgaaaagct gttttcaatg gaagaacaga 1156081 aaagagaaga tgtatttcgg tatacgatga tgaggccgtt tgaaaagatg tggaccgcca 1156141 tccaagttcc gctgaaagcg aaggagccaa acggctatga tgtgatcatg gctgcgaaaa 1156201 tgctgggcta tttggatgtc cgtgatgctg aaagcggcca gaaagcacta caaatactga 1156261 aagaatcaca tgtttcagag acagctgaat ctgcacttcg gcaatgcata ttttttgctg 1156321 agcgcgaaca gctgcgggtg aatgcaaagg agatcaaatt cggcctttat atcgctgatc 1156381 caaataagct tcagctgcaa aaaggctact gcgggtttgg cgggataccg ggctttattc 1156441 atgtatggat taatccgaac agttataacc tgccaaggat tccttccatt attgctcatg 1156501 agtttcatca taatgtgcgg ttttcgtata tagattttca tcatggctct gtaagtgtcg 1156561 gggattatct tgtgattgaa ggattggcgg aatcattcgc cagagagctg tttggtacgg 1156621 aacgattggg cccttgggta actcgttttg atcatgaaga cttgcaatat tccattgatg 1156681 tgattaatga ggtgctggat gtgaaaggat tttcggaagt cagccgttat atgtttggtg 1156741 atccaattgc taacgaccaa ggctttaagc ctgcaggttt atcggctttt gcgggttatg 1156801 cagttggcta tcatgccgtt cagtcattta tgaatcaaca tcatatcacg ataagcgagg 1156861 ccacacgttt ggatgcgaag accattattt ctcaatgcgg tctgttttct acatgaaaaa 1156921 agcgtcacat acagcggcgc tttttgattc ccaaaaccag cagttctatg gcggcacagg 1156981 cggcaattcc gattgtatat gcttcgatat cgctccataa aaaaccgtac cctagtacaa 1157041 gcccgccaag agaagtatct ctaatctggt cgatccattc ggcatgatag agctggctga 1157101 attcaatgac aaaacagaaa gaaagactga taatgcccgt tatcattgtc ttcagcttcc 1157161 gaaatagaaa tccgcatccc gtgaagatca tggcggccca caacgagtct cccagataag 1157221 tattgagggt atcaggaaga acactggaga atgctctgga tccaagcccc agcccaatga 1157281 tcagtatggt gaaaactgca tatatccaac gatttcgctt cattgcgaat tgataccccg 1157341 tctctgcttc atctccctgt attgtaagga atatagcttt tatttgtcca ctaaaaaagc 1157401 ggctgaatag ccgcgtaggg tgtttatttt gcttttaggt ttacatggtc ggctgtctga 1157461 tccgtgccta ttacaaaatg gagttcatag cggcctgtat catatacata atcgatttca 1157521 tcggtaaacg ggacggttaa cacccgattt actggtccta attgcttctg cagcacttcc 1157581 ggcgtaactc cgcctaaatt cagctgccgt tccacaccgg ttccaaagta gcggatttct 1157641 gaaattgtca tgtctttatg ataggaaaat ccgtagcccg gctgtcccat attccagtga 1157701 tataaatcaa atcgattgtc tcccccgact ggtctttccg gttccccaaa cgcagcgtgg 1157761 acatcccctt ttgtgctttt gttaatggta aggccttgcg cctgctgagg catttcccct 1157821 ttataggcgg tgttatagag gtttttgaca agctcagcgg ctgattgatt cgtgttttct 1157881 gagagtgtgt ttgtttgagc tgcggccttt gccggtgctg aaaaggacgc agccccaaag 1157941 ccggtaaaac agcttgttac tgctgctgcc gcggttatag cagacattgt ctttttcatg 1158001 ttaatccctc ctaattgatc taccattccg tttccccgtg tttttgcaac gaaacatgtg 1158061 agtgcgcttt gtatgtttta ttgagttgtt gtaagggaac tgaaataggt aattcggtat 1158121 ataaagcaag aaaggggaat ggagatggct ggcaagaaaa caatcacaat aaacggcgtt 1158181 gaaatggaag cgtccgagga acagacggtg ctgcagcttt tgaataacag ctcgattgaa 1158241 gtgccgcaag tttgctatca tccaagctta gggccgattg agacatgtga tacgtgcatc 1158301 gtcagcatca atggtgagct gaagaggtcg tgctccgctg aattaaagga tggggatgtc 1158361 attgatacgc tctcacctga cgtgaaaaaa gcgcaggtca tcgggatgga caagatttta 1158421 tataatcatg agctttattg tacagtttgc gattacaaca atgggggatg cgaaatacat 1158481 aatacggtga aggaaatgaa aatcaatcac caaagcattc cgtttgatca caagccatac 1158541 cataaggatg aatcccatcc gttttatcgg tatgatccag atcaatgtat attgtgcgga 1158601 cgctgtgttg aggcatgcca agacgttcag gtaactgaaa cgctgaccat tgactgggag 1158661 cggaaacgcc cgcgcgtcat ttgggataac gacgtgccga tcaatgagtc gtcatgtgtg 1158721 tcatgcggcc attgttcaac ggtctgtccg tgcaacgcga tgatggaaaa aggaatggaa 1158781 ggggaagccg gatatttaac aggcatcaat aacgaaacgc tgcgaccgat gatcgagatc 1158841 acgaaaggcg tagagacagg ctacggctcg attctcgcga tttctgatat ggaatcggcc 1158901 atgcgtgatg aacgaatcaa aaaaacgaaa accgtctgca cgtattgcgg cgtcggctgc 1158961 agctttgatg tctggacaaa gggcagagac attctgaaag tagagccgca ggaggaagcg 1159021 cctgccaacg gcatttctac ttgtgtgaaa ggcaagttcg gctgggattt cgttaacagc 1159081 gaagaacgcc tgacaaagcc gctgatccgt gaaggcgatc atttccgtga agcagagtgg 1159141 gaggaggcgt tattgctgat cgccagcaag ttcactgaat taaaagaggc gtttggcccg 1159201 gattctctcg cttttattac atcttctaaa tgtacaaatg aagaatccta tcttatgcaa 1159261 aagctggcca gaggggtcat tggcacaaat aatgtggaca actgctctcg ctattgccaa 1159321 tctcctgcga ctgccggcct gttccggaca gtcggctatg gcggtgattc aggatcaatt 1159381 acagatatcg cgcaagcgga ccttgttttg attatcggtt cgaacacgtc tgagtcgcat 1159441 ccagtcttat ccactcggat taaacgggct cataagctga gagggcagaa agtgatcgtc 1159501 gcggatatca gaaagcacga aatggcagag cgctcagatt tatttgtcca gccgcgtgcc 1159561 ggatcggata tcgtctggct gaatgcgatc gccaaatatt taatagaaaa cggcaaggcc 1159621 gatgaacgat ttttgagaga aagagtgaac ggacgggatg aatatgtaaa aagcctcgcg 1159681 ccgtacacac ttgaatatgc tgaggagaaa accgggattg atcaagaaac ccttatccaa 1159741 atggcagaga tgatcgggca agctgacagt gtgtgcgcat tgtgggcgat gggcgtgaca 1159801 cagcatattg gaggaagcga cacgagcacg gcgatctcta atctgctgct tgtgacagga 1159861 aactacggaa aaccgggagc aggttcttac ccattgcgcg gccataacaa cgtgcaggga 1159921 gcaagtgact ttgggagtat gcctgacaga ctaccgggct atgaaaaagt gacggacgaa 1159981 caagtccgcc aaaaatacga gcgtgtgtgg ggtgtgccgc tgccgaagga gccgggtatg 1160041 accaaccacg aaatgattga aaaaatccat tccggacagt tgaaagcgat gtatgtaaaa 1160101 ggtgaagaaa tgggccttgt cgactccaat atcaatcatg tacacgctgc atatgaaaag 1160161 cttgatttct ttgtggtgca ggacattttc ctttcacgta cagcggagtt tgctgatgtg 1160221 gttcttcctg cgagcccgag ccttgaaaaa gaaggaacgt ttacaaacac agaacgccgg 1160281 attcagcgtt tgtatcaggt atttgaaccg ctgggtgaat caaagccgga ttggcagatt 1160341 attatggagg ttgccaataa gcttggcgcc ggctggctct atgagcatcc tgcagacatt 1160401 atggaggaag cagccaagct gtcgccgatt tatgccggtg tcacctatga acgtcttgag 1160461 ggctataatt ccctgcaatg gcctgtaaac gctgatggaa aggattcgcc tttactcttt 1160521 acagagcgct tccctttccc agacggcaag gccattctct accctgtcca gtggacagag 1160581 cctaaggaat tcggtgagga atatgatatc catgtcaaca atgggcggct cttggagcac 1160641 ttccacgaag ggaacctgac ttacaaatca aaagggattt cggagaaaac accggaagtg 1160701 ttcttagaaa tttctcctga gcttgcggca gaacgaggga ttcaggacgg aaccctcgtc 1160761 agactcacat cgcctttcgg aaatgtcaaa gtgaagtgcc tgattactga tcgagtcaaa 1160821 gggaaggaag tatatctgcc aatgaacgat tcaggggaag cggcgatcaa cctgttaaca 1160881 ggcagccatg ccgataagga taccgatacg cctgcttaca aagaaacatc ggccaagatg 1160941 gaaattttga agcacgacgg aatcagcccg ctgcctaaga tcaaccaccg caacggcaat 1161001 ccgcagccgc aaatcggtgt gcaggttcat aagaaatggg cgcggaagga ttatattttc 1161061 cctggtgacg ctgtgaaaag ggggatgggc cataatggct aaagcgatta aacgaatcca 1161121 aaaaatcgag gtaacagaag aggatcagcg aaagcgtgat ttgcgggaaa ttgaagatgc 1161181 tctaattgac cacaaagaag cgattctcga aacattgcat atgctgggcc atatgaacga 1161241 gcgcggggtc ctgccgttgc tccgcggcct ttttggtcaa ggggataaag ttcttgatat 1161301 cctggtgaaa aaggcagata cagaggaaac agccaatacg ctgaaaaatc tgcttcttct 1161361 gtttggaaca ctcggcatgc tggacgtgaa gcagctggag cctctcattt tgaaagtgaa 1161421 tgcgggtgtg gcaagcgctg tagagcagaa aaacagtgaa gaaaagacag gttattttga 1161481 tattatccgc tcgctaaaag acccggaaat caacaaatca attacactgc tcttttcctt 1161541 tttaaaagga atgggacaag atacaaagga gctggaacgc acgacgcagc ctccggaaca 1161601 ccaaaaacat catcaggaac cccgagagaa aagaggaatg aataagcgag attgacctcc 1161661 cacccgagcg gcttcagcca gctcgggttt tttgatgaaa aggtctaatg gactagtaaa 1161721 aaatattcaa atactaggaa gaagtaagat tgtgatgaat gagatagaaa taatcgttac 1161781 tttcttacct gttaagaaaa gggaaaatct gattataata gaaatcgatt actttagatg 1161841 ggggaacaat catgaaaaaa gtcttattac tattatttgt cttgacgatc gggttagcgc 1161901 tttctgcgtg cagccaatcg agcgatgcgt cagagaagga aaaaccgaaa gagaaaaaat 1161961 cgcaagaaga gcttgaaaag gaacttgata aggaattgaa aaaaggcggt gagccgaaga 1162021 ccaaaaaaga tgatcaaata cataaaatag gagaaacatt taaagcagga catacgaatt 1162081 ttacagtgaa taaagttgat agagtgcaaa aaggtgaata tatgaatgtt ggcggagctg 1162141 taaatgagga gacaaaaaca ataaaagatg atgaggaacg gcttattata gaagttacga 1162201 tggaaaatat aggggaagat tcaataagct acaattttat cgggtttgat ttaagagata 1162261 agaatgatca atcagtgcgg cctgtttttt ctatagaaga gaagggcaga atccttatgg 1162321 gaggaacact agtatcgggg aaaaaggtta caggtgtact cagttatgtc atccctaaag 1162381 gagaacagaa acattacaca ctggtatata atccgttttt agctgataca aatagcagta 1162441 atacagaaga gagagtaaag gacgatattg attacttggt gaagttagat tagatgctaa 1162501 tttacagttg cacgtttttc atctgtggaa aacgtgcatt ttttatagcg aaacttgact 1162561 tgaaaggatg agtgataaaa gtgcaaacca aatggctgga acgggcacag cggattcggg 1162621 cgatcgccca agcggggctt gctttttcca aggatgtgta cgacagggag aggtacgaag 1162681 agctaatgaa gcttagcgcg gaaatgatgg cggattactc ggagaaggac attgaagtta 1162741 tcactgattt atggcaaggc gagaagggct atccaacacc gaaagcggat gttcgcggcg 1162801 ctgtattcag agagaatcag attttgcttg tccgggagaa gcatgatgag ctgtggtcgc 1162861 tgccgggcgg attttgcgag attggtttat cgccggctga aaacgttgtc aaggaaatca 1162921 aagaagagtc ggggtacgat acagagccgt ctcgattgct ggccgtgcta gacagccata 1162981 aacactctca tccccctcag ccttatcact attataaaat cttcatcgca tgcagcatga 1163041 cggacgggca gggggaaaca gggatcgaga cgaatcatgc cgcttttttt ccggaagaca 1163101 gactcccgcc gctttctcct aaacgaaaca caccctcaca gcttagcatg ctgtttgact 1163161 ttttgcgcca tccggacaag aaaacgatat ttgactaaaa aagaaagagc ctgtgggctc 1163221 tttctttttt ataatgtaat gtgtttttcg ttggcgagtt tcagaagggt caaaatagaa 1163281 tcggcttgtt tatggccgag tttttgcttt aatttgtttt cttcaactaa tcggctgcca 1163341 taaattttga cggaggcttt gtcgacgaca gtatgccagt tttcctgttt ttttccctca 1163401 acaagcggtt tttcatgtct ctcagaaaaa gagaacacaa agagtacgaa tgcaagtgaa 1163461 agtaggattc cgacaacttg ttttttgtaa tcagtctgtg ctgccacgtt gttctctcct 1163521 tcacctttta ccttctattt aatcatagaa ccaaattatt ttacataatg ggaaagtcat 1163581 ttttggagtt agtgcatttg gttgaaaaca gagacgtttt ttgagcggag cggtgcaatt 1163641 gaatccatat tggatttgcg tgcttatgcc taaggtcacg ttgtgagcca aaacagcagt 1163701 gcagaataga aaaaaattga aagattatgg taagatgaac gaaattcgag ggggaatata 1163761 tgatgcctgc atcgaacatc gtgatcgcct gcctgctgtt atcaatttaa ttatttgtgg 1163821 tagtccctct ctttttcgaa agcgggaggt gaagtggaac attaattgct gaattctttc 1163881 aaggggagtg accgtacatg aatgtgttaa accgccggca agccttgcag cgagcgctgc 1163941 tcaatgggaa aaacaaacag gatgcgtatc atccgtttcc atggtatgaa tcgatgagaa 1164001 aggatgcgcc tgtttccttt gatgaagaaa accaagtgtg gagcgttttt ctttatgatg 1164061 atgtcaaaaa agttgttggg gataaagagt tgttttccag ttgcatgccg cagcagacaa 1164121 gctctattgg aaattccatc attaacatgg acccgccgaa gcatacaaaa atccgttcag 1164181 tcgtgaacaa agcctttact ccgcgcgtga tgaagcaatg ggaaccgaga attcaagaaa 1164241 tcacagatga actgattcaa aaatttcagg ggcgcagtga gtttgacctt gttcacgatt 1164301 tttcataccc gcttccggtt attgtgatat ctgagctgct gggagtgcct tcagcgcata 1164361 tggaacagtt taaagcatgg tctgatcttc tggtcagtac accgaaggat aaaagtgaag 1164421 aagctgaaaa agcctttttg gaagaacgag ataagtgtga ggaagaactg gccgcgtttt 1164481 ttgccggcat catagaagaa aagcgaaaca aaccggaaca ggatattatt tctattttag 1164541 tggaagcgga agaaacaggc gagaagctgt ccggtgaaga gctgattccg ttttgcacgc 1164601 tgctgctggt ggccggaaat gaaaccacta caaacctgat ttcaaatgcg atgtacagca 1164661 tattagaaac gccaggcgtt tacgaggaac tgcgcagcca tcctgaactg atgcctcagg 1164721 cagtggagga agccttgcgt ttcagagcgc cggccccggt tttgaggcgc attgccaagc 1164781 gggatacgga gatcgggggg cacctgatta aagaaggtga tatggttttg gcgtttgtgg 1164841 catcggcaaa tcgtgatgaa gcaaagtttg acagaccgca catgtttgat atccgccgcc 1164901 atcccaatcc gcatattgcg tttggccacg gcatccattt ttgccttggg gccccgcttg 1164961 cccgtcttga agcaaatatc gcgttaacgt ctttgatttc tgcttttcct catatggagt 1165021 gcgtcagtat cactccgatt gaaaacagtg tgatatacgg attaaagagc ttccgtgtga 1165081 aaatgtaata gataaggaga ctggagattc atgaaaaagt accatatttc gatgatcaat 1165141 atcccggcgt acggacatgt caatcctacg cttgctttag tagagaagct ttgtgagaaa 1165201 gggcaccgtg tcacgtacgc gacgactgag gagtttgcgc ccgctgttca gcaagccggt 1165261 ggagaagcat tgatctatca tacatccttg aatattgatc ctaagcaaat cagggagatg 1165321 atggaaaaga atgacgcgcc cctcagcctt ttgaaagaat cactcagcat tctgccgcag 1165381 cttgaggagt tatataagga tgatcagcct gatctgatca tctatgactt tgttgcgctg 1165441 gctggtaaat tgtttgctga aaagcttaat gttccggtca ttaagctctg ttcgtcatat 1165501 gcccaaaatg aatcctttca gttaggaaat gaagacatgc tgaaaaaaat aagagaagca 1165561 gaggctgaat ttaaagccta cttggagcaa gagaagttgc cggctgtttc atttgaacag 1165621 ttagctgtgc cggaagcatt aaatattgtc tttatgccga agtcttttca gattcagcat 1165681 gagacgttcg atgaccgttt ctgttttgtc ggcccctctc tcggagaacg gaaggaaaaa 1165741 gaaagcctgt tgattgacaa ggatgatcgc ccgcttatgc tgatttcttt gggtacggcg 1165801 tttaacgcat ggccggaatt ttacaagatg tgcatcaagg catttcggga ttcttcatgg 1165861 caagtgatca tgtcggttgg gaaaacgatt gatccagaaa gcttggagga tattcctgct 1165921 aactttacca ttcgccaaag tgtgccgcag cttgaggtgt tagagaaagc tgatttgttc 1165981 atctctcatg gcgggatgaa cagtacgatg gaagcgatga acgcaggtgt gccgcttgtc 1166041 gtcattccgc aaatgtatga gcaggagctc actgcaaatc gggttgatga attaggcctt 1166101 ggcgtttatt tgccgaaaga ggaagtgact gtttccagcc tgcaggaagc ggttcaggct 1166161 gtatccagtg atcaagagct gctcagccgc gtcaagaata tgcaaaagga tgtaaaagaa 1166221 gctggcggag cggagcgtgc ggcagctgag attgaagcgt ttatgaaaaa atccgctgtc 1166281 ccgcagtaaa aacataaaaa ccgaaatcaa tttgatttcg gttttctgtt taaatatttt 1166341 ttttcatccc gcatctccgg cattctctaa gaaattttcc gccttttaca gagcttttga 1166401 acagtgtgta atcacagttg tcgcagcgcc cgctgcgggc atccggatat tcattgaatt 1166461 cgtaaacaat cgatgtatcg tagccttttg tttcatattc ttcttttttg gtttccatgt 1166521 cgatcctccg ttacaagacg tgtctgctgt ttatcttaca gcaagcttcc ggcgtattca 1166581 atggatttta ggaggttggg tttatcttga tttctccctt ggtttgcgcc aaaatagctt 1166641 tattaagctt atatacataa aaagcctatg caaagaggag aggaaacggg tatgggaaaa 1166701 gggttacttg gaaaacgcgt ggcaatcggt ggctcacgaa aaacggaaga aattagtaca 1166761 atcattgaaa aacagggcgg aatacctgtc atccggcctc tccaaggtac agtttactta 1166821 gcagagaagc aggtggagcc ggatttgcgg acgtttgcgg aagaaaaagc tgactgggtc 1166881 attttcacga caggcatcgg gttggagact cttgtcgata tggcagagaa aattggactg 1166941 aaagatgagt ttctgcaggc cattcgccaa gcgaaagcgg catgccgggg atacaaaacg 1167001 ctgtctgcgc tgaaaaagct tggaatcaca ccggaagctt cggatgaaga cgggacaaca 1167061 agaggcttaa tccgttcctt ggagcctcac gacttttcag gaaaaacagt catggtgcag 1167121 cttcatggcg aaaaagcgcc ggctctcatg gcatttcttg aagaaaaagg cgcgtctgtc 1167181 ctgccgattc tgccttatca gcacatcccg ccggaggagg aaacggtgga gcggttatgc 1167241 cgagagctga tgaacgatga ggtcgatgcc gtttgtttta caacggccat tcaggttcgt 1167301 tccctgtttg attttgccaa ggggcgaggt tatatcaatg aagtgaagaa ggtattcgaa 1167361 gaacgcgcca tcgcagctgc tgtcggaaaa gtgactgctg aagcactgcg ggaagagggc 1167421 attacgagac tgcttgcgcc agagattgag cggatgggtg cgatgattgt tgagctggcc 1167481 aagtattatg aagaaaagga ataacaagta caaaaagccg cttttccctc ggaaagcggc 1167541 ttttgtctgt cattcatttt gcttcagctg ctgatgaacg gtgaataatg atgggtatgt 1167601 cagcacgctt aagattacac aagtcagcgc ggctgaggcc atcgttgtaa acacgattaa 1167661 gagttgaaag cgtactgcct gaatcgggtc cgcgccggct agaatctggc cagtcatcat 1167721 gccgggaagc tggacaagac ccagtgtttt ctggctttcg agcgtcggga tcatactcat 1167781 tttcatcgct gaggtaagaa tgcgctgtat ggattgcttc ggtgtgccgc caagtgacaa 1167841 tattaattga atttcttctt tgcgaacgcc gacttctgag ttaagccggt ttagaaacaa 1167901 acttgagagc accatcgaat ttccgatgac catcccgctg atcggaatga catatcgtgc 1167961 cgtaagcgga atgatatgaa gagacagcag aattccctgc gtcacaattt ctacgattgc 1168021 taacgcggca aacaccctcc aaaacgaacc gatagtattt ttctttcgct tgatgacatt 1168081 ttgcgccgcc accgcgagca ttaacagcac catcagcagg ataaaaacag ggtggtctcc 1168141 gcgaaaaatc agcgacaaaa cataaccgat gataagcagc tgcaccgcgg cccggatggt 1168201 ggcgatgatc atgtcttttt ctacaccggc tttaaaggat tttgataaaa acaaggcgat 1168261 caaaacaaag atcatcgtta aagagagaga aaggtaatcc attaccgagt gcctcccttc 1168321 aaaaattctt tcgctgcttc atgctgcgga gcggagaaaa atgtgtcggt ttcagcgatt 1168381 tcaagcagcc ggccatctgc cataaaccaa atggtatcgg ctattcgttt tgcctgctcc 1168441 atattatgag tgacccacat gactgtccat tttttctctt gatgctgacg tttgatcagt 1168501 tcttcaatct caagagcaga gaccgggtcc aaggccgatg tgatttcgtc caacaataga 1168561 atggaggaag gatttgagag cgttctggcc agtgacagtc tttgccgctg cccgcccgat 1168621 aagtctctgg cgcttctgtc taacaactct ggcggcagcc ctgcaagcga agccagcttt 1168681 tcaggagagt acagctggga ttgatgcagc ctttgtacaa gacttaaatt gtcacgcact 1168741 gtcccgtcga gcacgggagc cgattgaaac gcgagggctg ccgttcgcct cagctcattg 1168801 acattccatt ctctgacttc ctttccgtat atgttgactt cgccgctgtc aggcgttctc 1168861 attaaattac acatagaaag gagggtgctt ttgcctgagc cggaagggcc taaaacggct 1168921 acgattgcac cctgttgaat gtctccggtg acatcctgca gcacatcata ggtttgtcca 1168981 tcttgtttat agctttttct gactgatctg aaggagatgg ctggtatgtt ttgtgtttga 1169041 tcgtttgctt ccattacaat aatcaccttt caatataagt aggctgacat tatatttaac 1169101 tataacgtga aacagattcc ttttggtagc acaaataaag gagaacaggc tttcacccat 1169161 tctcctgcag atgctacgca gtcagatttg actgtgcttt ctttttcggt tttctcggct 1169221 gtgaagcgaa ggtatgtaac atcatccccg ctattataat gaacaaaccg gcaaatgata 1169281 atagagatgg gaaaacgcct gacagcagaa caatttcacc aagcagcgcg aaaatcactt 1169341 caccggattg agtggcttca acagctgcga gtttttgcgg attgtctctt accatatcag 1169401 tggcccagaa aaataaaacc gtcgcaatga tgcctgagct gacggcaacg ataaaggatt 1169461 gaacggtttg acttgctgtt ggaaggccat ctgaccacca gccgtaagct gctaatataa 1169521 gccagaatgg aaggcttgcc aatgtcattc caagcacgcg ctgaaatgta tcaagccggc 1169581 ctccgtattc ttcgagcatt cttcggtttc ctaacggata ggcaaaagcc gcaatgacaa 1169641 ccggcagcac actgaaaagc agcatcctcc cagaaagcga ttctgcatgc tgaagctgaa 1169701 tcagagccgc tccaatcagg atgatcacag aagtgccaag tgaaaccagg ggaatctttt 1169761 ggcgaatgag ctgcggaccg cccggcatat cttgtttgac ataaaacaaa ggagataaga 1169821 gcaccccggc tacaattgta atttgccagg ttccagctat gagccacccc ggaccgtatg 1169881 cagccgcaaa tgtaatcggt gcgtaaaaaa gcacgaaacc gacgaagctc catttgatcc 1169941 aataaaacgg ctttttcctc atttctagta agagaggcgt gaatgtccct ctcatgatga 1170001 caatcaaaca taaaaatggc accataaaaa taaagcgcag cgaagagctc caaagccagc 1170061 tgcctcctga taactccatc gctctgttta atataaaggt aacggcgaaa aagagtgaag 1170121 ccaatattcc gataacgata gctttcatga tatccctcat tctggcatta tttttttata 1170181 ctatactatt cggtatcatg cagatcaatg gaatcatgag aaaaacatca tgtttggcga 1170241 accgctatat gtggaagaca aaaaagggag gtgaaattga tggaaagaga gacacagaca 1170301 tacttctttc cggatgacgg caggattccg aatcaccctg attttccgct cgtggtgtat 1170361 caaaacgcgc ttaaggacac cggactggca gagcggatcg tcacccggca tggctggtca 1170421 aacagctggt cagggagtgt ttttccatac catcattatc acagcaatac gcatgaagtc 1170481 ctgattgccc ttaggagaga ggctgtgatt cagtttgggg gagaaaaagg ggctgccatc 1170541 cctttcaaat caggcgacgc agtcgtgatt ccagccggag tcggacataa aaagctcagc 1170601 tcaagccccg attttactgt ccttggcgcc tatcccggtg gcgttcagta cgatatgaag 1170661 acggggaagc cgaatgagcg ggaggaagcg gtcaaacaga ttaagcaggc ggcgttgccg 1170721 gcgaatgatc cgatcacagg aaaaagagag cctctattgg aaatatgggt aaagtgaagg 1170781 ggagaaattg ctggattgtc aataactagt gccgcagaaa cgatatgaca tgagctccat 1170841 ataaattaat ttcataatcg aagcaattca cgttcaaatt ttgttcaaaa agtgttatca 1170901 tatagaaggt aatcgaattg gagttttttg tgtttgctat tttcagagag agtaaaggat 1170961 tttgacttat tcaattgttt atttttagat aaaaataata ctgaatatgg caagatgaaa 1171021 aactgggtag taaacattta tttttgtaaa tgattgtgca tgaattcaca atccttattc 1171081 ttatgcctta aaagcgtgag acagggagag gcactaccct ttccaaaaaa atcagcaaac 1171141 tgcttatagt aaaggagaat tggatatgcc agaaacaatc gatcaaacaa atgcgtctgt 1171201 cagccaaagc cagcaagatc ttattgatca gctattaaag ccagaagttc aagaatcatt 1171261 gactgtttta gttgaccagc ttccgaagct gactgagtta gtgaatattt taacgaagtc 1171321 ttatgatttc gctcagtctg tagcgactga cgaagtgtta aagagcgaca cagtcggtgc 1171381 gatcactgaa attctcgagc ctgtaaaaga aacagcgaaa gaagtagctg cgactgcgat 1171441 cgaagcaaaa gaccgcgcgg aagcaagcaa cgaaacaatt ggacttttcg gccttcttcg 1171501 catgctgaaa gatcctcaag ctcaaaagct gttccgtttt gctaacagct accttgaagt 1171561 catgaacgaa cgcgaaaacc aaaaataatc tcagattcaa attgatataa aggacggagg 1171621 atatacgatg tcaaaacata ttgtcattct aggcgctggt tatggcggag ttctttctgc 1171681 tctaacagtt cgcaaacatt acacaaaaga acaagcacgc gtgacagtgg taaacaaata 1171741 cccaactcac caaatcatta cggaattaca ccgccttgct gcaggcaacg tgtctgaaaa 1171801 agcggttgca atgccattag aaaaactttt caaaggcaaa gacattgatc ttaaaattgc 1171861 ggaagtaagc tctttctctg ttgataaaaa agaagttgcg cttgctgacg gttctacatt 1171921 aacttacgat gcgcttgttg taggtcttgg ttctgtaacg gcttacttcg gcatcccagg 1171981 tcttgaagaa aacagcatgg tattgaaatc tgctgccgat gcgaacaaag tcttccaaca 1172041 tgttgaagat cgtgtgcgcg agtactctaa aacgaaaaac gaagcagatg caacaatcct 1172101 tatcggcgga ggcggcttaa caggtgttga gcttgttggt gagcttgctg acatcatgcc 1172161 gaaccttgcg aaaaaatacg gcgtagacca taaagaaatc aaattgaaac ttgttgaagc 1172221 aggtccgaag atccttcctg ttcttccgga tgatcttatc gagcgtgcga ctgcaagcct 1172281 tgaaaaacgc ggcgttgagt tcttaacagg tcttcctgtt acaaatgtag aaggaaacgt 1172341 aatcgatctg aaagacggat ctaaagttgt tgccaacaca tttgtttgga ctggcggcgt 1172401 acaaggtaac ccattagtcg gtgaatcagg cctagaagtg aaccgcggac gcgcgactgt 1172461 aaatgacttc ctgcaatcta catctcatga agatgtattc gttgctggag acagcgcagt 1172521 ttacttcggt ccagacggcc gtccataccc gccaactgca caaatcgcat ggcaaatggg 1172581 tgagctgatc ggttacaacc tattcgctta cctagaaggc aaaacgcttg aaacattcaa 1172641 gccagtaaac tctggtacac ttgcaagcct tggacgcaaa gacgcggttg ccatcattgg 1172701 tgctaattct acaccgctta aaggtcttcc tgcttccttg atgaaagaag caagtaatgt 1172761 acgatatttg acacatatta aaggactttt cagcctggct tactaatcct tttaatgaat 1172821 ctggcattgc caaaagcatt cctttccgag tgctttctgg caatgtcttt ttttatgttt 1172881 atgacagcgt taacatttca ttttcaaaaa agagattgat cccaaaggaa tataaaggta 1172941 aaataaaaac aaatcaaaat gttaacgtta acattttgaa atagaatgaa agacggtgag 1173001 gacatggaac ccttcatggg caaaaacttt ttattgaaaa atgaaaccgc tgtcagcctc 1173061 tatcacaatt atgcgaaaga catgccaatt attgattacc actgccactt aagtccgaaa 1173121 gaaatctatg aaaataagac atttcaaaac atcacggaag cctggctgta tggtgaccat 1173181 tataaatggc gcatcatgag agccaatgga attgaggaga catacattac cggagatgcg 1173241 cctgatgagg agaaatttat ggcttgggcg aaaaccgtgc cgatggcgat tggcaacccg 1173301 ctctacaact ggactcactt agaattgcag cgtttttttg gcatttacga gattttaaac 1173361 gagaagtccg ggtcggctat atggaaacag acaaataaac tgctcaaagg ggaaggcttc 1173421 ggggcaaggg atttaatcgt gaaatcaaat gtaaaggtcg tgtgcaccac agatgaccct 1173481 gttgattctc ttgaatacca tttattgtta aaagaagaca aagactttcc tgtcagtgtg 1173541 ctgcctggat ttcggccgga taaaggactt gagatcaatc gtgaaggctt tcctgagtgg 1173601 gtgcaggcgc ttgaagatgc cgctgccata tcgattacaa cctatgatga gtttttaaag 1173661 gcgttggaaa aacgagtgcg attcttccac tcagccggcg gcagagtttc tgatcacgcg 1173721 atagatacaa tggtatttgc cgaaacaaca aaagaagaag ctggacggat tttttctgac 1173781 agattacaag gaacagaggt ttcttgtgaa gatgagaaga aatttaagac atatacgctt 1173841 cagtttcttt gcggtttgta tgcggagctc gattgggcga tgcagtttca tatcaacgct 1173901 ttaagaaaca cgaatacaaa aatgatgaaa aggctcggac ctgatacagg gtatgattca 1173961 atgaacgatg aagaaattgc taagccttta tacaagctgc tgaactcagt tgagatgaag 1174021 aaccagctgc cgaaaacgat tttatattca ctgaatccaa atgataacta tgtcatcgcc 1174081 agcatgatca acagttttca ggacggtatt accccgggaa aaatacaatt cggcacagcc 1174141 tggtggttta acgatactaa agacggaatg ctcgaccaaa tgaaagcgtt atcaaatgtt 1174201 ggccttttca gccgttttat cggcatgctc accgattcca gaagctttct ttcgtatacg 1174261 cgccacgaat atttcaggcg gatcgtctgc aatttgattg gagaatgggt ggaaaacggc 1174321 gaagtgccgc gcgatatgga gcttctggga agcatcgttc aggggatttg ctatgacaat 1174381 gcgaaacact actttcaatt tcaagaagag aaagcaaacg tgtaacaaag tgtccgctca 1174441 gtatcgctga gcggatcact atccgaaaat tcttaagaca cagaggtgga acatgcgaac 1174501 tgaactggca aataaggttg tgtcggtcga aacggaaaaa aggctttcat tgaaagagaa 1174561 aatgtcctat ggctttggtg attttggcaa cggttttatg tttgatctcg gccagattta 1174621 tttattgaag tatttcactg atgtagcggg aatccccgct gcgatggccg gcggcatttt 1174681 tttagtcagt aagctgtttg cagcgataac agatccaatt gtcggctcat caatcgatta 1174741 tcgcaaaaac atcggcaaac gggggaaatt caggccttat ctattaatcg gcagcatcgt 1174801 gcttgcggtg cttactgttc ttatttttct gtctcccaat gtatcaacga ccggaaaact 1174861 gatatatgca tatgcatcct atatgatttg gggcatcggc tattcgtttg tgaatattcc 1174921 gtacggctca ttaggggcag cgatgactca aaattctgag gaccggacct ccatttcgac 1174981 gttccgccaa atcggatcac ttggcgcctt gtttatcaca agtgtggccg tgatgccgct 1175041 gctcgtcaag tttgataatc cgaaggtcgg ctacccggtg gtcatgggct tgttcgccgc 1175101 gctcggtgtg ttttggtttt atatttgcta ccgcaactgc aaagagcgca ttatcatatc 1175161 ggaagcaccc aaagaaaaat taacactctc atctgtcgtc aaaacattta ttacaaataa 1175221 accgctgtta acccttgtcc tgatgacgat tttttcaatt tccgcataca acattaaatc 1175281 cgccatgctc gtctatttcg cacaatataa cttgggcaat gttgaattaa tggcttatat 1175341 gaacttcatc attattggtt cttccttttt gggcgtcgta ttccttccaa agctcgtcaa 1175401 gatgtttgga aagaaacgaa cggcaatgat cggctttggc atcagtgtgg ccgcggatct 1175461 gatcaacttt atgcttccat ctaacgttta tgtgtttaca attctcgcca gtatcgcctt 1175521 tatcggaatc agtatcccaa atggcatcac gtgggctctt gtctccgata ttatcgacta 1175581 tggcgaatgg aaatccggtg aacggaagga agcaacgaca tattcacttt tcaatttctc 1175641 aagaaagctt gctcaatctt tgtctggctt tctctcgggg atcggtttgg ggattatcgg 1175701 ctatgtgccg aatgcagtcc agacagcaca ggcgctgatt ggcatcaaag cgctgcttct 1175761 tctgtatccg gccattgctt tggcattagc gatgttcatt atcggctttc tttataaact 1175821 cacagaccag cagcatgctc agatcgttca ggatcttcat caaaagagct gacaatataa 1175881 tataaagaat atttaaaata atttgtaaat aaaatgtgtt tgtaggggtt tcgcttggag 1175941 agtgcccaaa aaactgaaaa ggaaggaggc acttgcttga aaacgataac aattgcagct 1176001 gaagaagcaa aggaactcgt ttggcaaaag ctggacggtg ccggtttgaa tgaacgagat 1176061 gctgaaaaag tggcagatgt tctcgtgcac gctgatttgc gcaatgtaca ttcgcatggc 1176121 gtgctgcaca cagaacacta tgtgaacagg cttttagcgg gagggatcaa tcctggggca 1176181 cagcctgttt ttaaagagac ggggcctgtg accggggtgc ttgacggaga cgatggtttc 1176241 ggtcatgtga attgcgacat ggcgatggac catgcaattg acatggcgaa gaaaaaagga 1176301 gtcggcatgg tcacggccgt aaacagcagc cattgcggag cgctaagcta ttttgtgcaa 1176361 aaagcggctg acgaaaagct gatcggaatg gcaatgacgc atacagacag tatcgttgtc 1176421 ccatttgggg ggaggactcc tattttaggg acaaatccga ttgcttacgg agttccggct 1176481 aagcataaaa aaccgtttat cctagatatg gcgacatcca aagtggcttt tgggaagatt 1176541 ctgcaggccc gtgaagaggg caaagaaatt cctgaaggat ggggagtcga tgaaaacgga 1176601 gaagcagtaa ctgatcctga caaggtcgtc tcactttcaa cattcggggg cccgaaaggc 1176661 tatggactat cgattgtagt ggatgtgttt tccggattgc tggcgggcgc ggcttttggc 1176721 cctcatattg ccaaaatgta caacggcctt gatcaaaaaa gaaagctggg gcattacgtt 1176781 tgcgcgatca atccatcctt ttttactgac tgggatacgt ttttagagca gatggatgcc 1176841 atgattgatg aactgcagca atcaccgccg gctgttggat tcgaaagagt gtatgtgccc 1176901 ggcgagatcg agcagctgca tgaagaaaga aataagaaaa acggaatttc tatcgcccgg 1176961 agcgtgtatg aattcttaaa aagcaggtga gtaaaatgaa agcggttcaa gtgcgaaaag 1177021 cgtatgatct ggtgacagcg gaggtgaaga agccagttct ttcaaaggat gatgaagtgc 1177081 tcgtgaaagt caagcgagtc ggcatttgcg gttcagacat gcacatttat catggaacga 1177141 atccgctcgc taccctcccg agagtcatcg gacacgaggt aacgggacaa gtggaggcag 1177201 ttggtgcgaa tgtacagagc ctaaaacccg gtgatcatgt ggtgattgag ccgatttctt 1177261 attgcggatc gtgctatgcc tgccgcaaag ggcggccgaa tgtttgcgcc aagctttctg 1177321 tatttggcgt acatgaggac ggaggcatgc gggaatatat tgtgcttccg gaaagacagc 1177381 ttcacgcggt ctcaaaggac ttgccttggg aggaagcagt catggccgag ccttatacga 1177441 taggcgccca ggcagtgtgg agaggccagg tggaaaaagg tgataccgtc ctgatccagg 1177501 gagcggggcc catcgggatc tgtgtgttaa aaatggcaaa actggcgggc gctgctgtca 1177561 tgatgactga cttgaacaac gagcggctgg catttgcgaa agaaaacggc gccgatgctg 1177621 ttgtaaatgt ccaagcagaa catgttgccg agcgggtcct tgaatggact gggaatgaag 1177681 gagcaaacgt ggtcattgat gctgtttgcc tgccggagac ttttgcactt tcaattgagg 1177741 ctgtgtcacc ggcgggacat gtggttgtgc ttggatttga tgaaagagcg gctcagattt 1177801 ctcagctgcc aattacaaaa aaagaagtca cgataaccgg atcccgattg cagaccaatc 1177861 agtttccaaa agtggtagag cttttgaatg gaggccggtt aatgcataac gggctggtga 1177921 cccatacatt ttcagttgat gacgttcatc atgcatttca gtttattaag gagcatccag 1177981 atcaggtgcg gaaagccgtc atcacgtttg attaaatgac tgaatccgga ggtgcgagca 1178041 tgaatatgac attccgatgg tatggacgag gcaacgatac agtcacactt gaatacgtga 1178101 agcaaattcc cggtgtcaaa ggcatcgttt gggctctcca tcaaaagccc gtcggcgacg 1178161 tgtgggaaaa agaagaaatc agagccgaaa ctgaatatat tcaatcctat ggttttcatg 1178221 ctgaagttgt agaaagcgtg aatgttcacg aagcgattaa acttgggaac gaagaacgcg 1178281 gccggtatat tgaaaactac aagcaaacga tccgcaacct tgccggattt ggcgtgaaag 1178341 tgatctgcta taattttatg ccggtttttg attggacacg cacggacatg ttccggccgc 1178401 tagaagatgg atcgaccgct ctgttttttg aaaaggccaa ggtggaaagc cttgatcctc 1178461 aagagctgat tcggacggtg gaggaagcat ccgacatgac actgccgggg tgggagcccg 1178521 aaaaattggc tcggatcaaa gagctttttg ctgcctacag aacggtcgat gaagaaaagc 1178581 tatgggacaa tttatcattc tttttgcagg aaattcttcc tgttgctgag gcctatggtg 1178641 ttcaaatggc cattcatccg gatgacccgc cgtggccgat tttcggactg ccgcgcatta 1178701 tcacaggaga ggcaagctat aagaaactgc gggcgatatc agattcaccg tctaattgta 1178761 tcaccctttg tacaggttca atgggagcca atcccgctaa cgacatggtg gagatcgcta 1178821 aaacgtatgc cggcatcgct ccattttcac atattcgcaa tgtgaaaatt tatgagaatg 1178881 gcgattttat tgaaacatct catttaacaa aggatggttc gatcaacatt caaggcgtga 1178941 tggaagaact gcataagcag gattacgaag gatatgtcag accggatcat gggcgccatc 1179001 tttggggcga gcaatgccgc ccgggatatg gcttatacga tcgggcactt ggcatcatgt 1179061 atttgaacgg gctgtgggac gcttatgaag caatggcaaa aaaagaggtg ggcatatgat 1179121 cccgctgcat gagaacctgg ctggtaaaac ggctgtcatc actggcggca gcggcgtgct 1179181 ttgctctgcg atggcccggg agctagcccg tcatggcatg aaggtggcga ttttgaatcg 1179241 gacggctgaa aaaggccaag cggtcgtgaa ggagataacg gcggctggcg gcacagcgtg 1179301 cgctgttgct gcggatgtgc tggacaggat gtcactggag cgggcaaagg aagacatcct 1179361 tggccaattt ggcgctgttg atctgttaat taacggggct ggcggcaatc atcctgacgc 1179421 gataaccgat gtggagacat atgaagaagc gggagaaggc caatcctttt ttgatatgga 1179481 tgagaggggc tttctaactg tattctccac caacttcacc ggtgcgtttc tggcctcgca 1179541 agtgtttggt aaagaactgc tgaaggcgga ttcacccgcg atcatcaacc tttcttccat 1179601 gagtgcttat tcacctatga cgaaggttcc ggcatacagt gctgcgaaag catccatcaa 1179661 taattttacg atgtggatgg ctgttcattt tgccgaaacc gggctgcggg tcaatgcgat 1179721 tgccccaggc ttctttctga caaaacaaaa tcatgatctg ctgatcaacc aagacggaac 1179781 gttcaccagc cgatctcaca aaattattgc gggaacaccg atgaagcgct tcggaaaacc 1179841 ggaggatttg ctcggtacgc tcctttggct ggcggatgaa tcctattccg gttttgtcac 1179901 tgggatcacc gttcctgtcg atggaggatt tatggcttat tcaggtgtgt aacgaaagcg 1179961 gtgcaacaga aactgaacca acataggggt gaggttgaga tgttttcaaa agataagctt 1180021 cccgttatcc tttttttgtt cctggcaggg gtgattaatt acctggatcg ctcggcgctt 1180081 tccattgcag ctccttttat tcaggatgat ctcacattgt ctgccacaca aatgggcttg 1180141 attttcagca gtttttcgat aggttatgcc atttttaatt ttcttggggg cgtggcatcc 1180201 gaccgctatg gggcaaagct gaccttgttt gtcgcgatgg ttgtttggtc gctgtttagc 1180261 ggagcagtcg ccctcgcttt tggctttgtc agcctgctga ttatacgcat tctcttcgga 1180321 atgggagaag gcccgctttc ggcgaccatc aacaagatgg tgaacaactg gttcccgccg 1180381 acccagcggg cgtccgttat cggtgtaacc aacagcggca cgcccctcgg gggagccatt 1180441 tccggcccga tagtcggcat gatcgcagtg gcgttcagct ggaaggtatc cttcgttctc 1180501 attatgatta ttggattgat atgggcagtg ctctggttca agtttgtcaa agaaaagccg 1180561 caagagacga tcaaggaagc accggcaata aaagcagaaa cgtctcccgg agaaaaaatt 1180621 ccgctcacct tttacctgaa gcaaaaaaca gtcctgttca cggcgttcgc ttttttcgct 1180681 tacaactaca tcctcttctt ctttttgaca tggtttccga gctatcttgt cgacgagcgg 1180741 ggattaagtg ttgaatcgat gagtgtcatc acggtcatac cgtggatttt aggatttatc 1180801 gggctggctg cggggggatt tgtttctgac tatgtgtaca aaaaaacggc ccgaaaaggt 1180861 gtgctgttct cgcgcaaggt tgtgcttgtc acgtgtttgt tttcatcagc tgtcctgatt 1180921 ggttttgccg ggcttgtggc aacgactgcg ggggctgtca ctcttgtcgc tctgtcagtg 1180981 ttctttcttt atttgaccgg tgctatctat tgggctgtca ttcaagatgt ggttgatcaa 1181041 aacaatgtcg gttctgttgg cggcttcatg catttcctcg ccaacacggc aggaattatc 1181101 ggcccggctt taaccggatt tattgttgac caaacaggca cgttttctgg agcatttttg 1181161 cttgccggtg ggctggctgt cttcgcttca cttgctgtga ttcgttttgt ccgtccaatc 1181221 attggtaagc cagcgggaac agaagctgag aatcctgtgt cttattaatc tggaaatata 1181281 gtgggagagg cggtatgttt gatgatacaa tatacagtaa ataatcgcag ccggtatgat 1181341 aaggaaggga attagatggt aaccataaaa gatatcgcaa aactcgcaaa cgtatcccac 1181401 actactgttt ccagagcact caacaacagc ccttacatca aagaacatac gaagaaaaaa 1181461 atattagagc tagcagagca gctcaactat acaccaaatg taaatgcgaa aagtctggcg 1181521 atgcaaaagt cgcatacgat cgggctattc tttacaagca ttacaaacgg aacctcacac 1181581 agcttctttg cagacactat caaaggcgtc aatcaagcca taagtgagga ttacaatctg 1181641 tatgtgcgcg gcattgatga tctgaaaaac tatgactccg ttacaccgat gagatatgac 1181701 ggcatcattt taatgagcca aagtgacatt gataattctt ttatttacca tattcgcgaa 1181761 aaaaacattc cgcttgtcgt gctgaatcgt gatattgatg atcgtaccat cacgaatatt 1181821 ttgtccaatg acaaggaagg ctctcaagaa gctgtagaat acttcattca gtccggacat 1181881 caagacatcg ccatcatcga ggggatcgaa ggctttaaat cctcccagca gcgaaaggaa 1181941 gggtacttat ccgcactgat tcaacatcat attccgatca agcatgaata cagtgtcaaa 1182001 ggacagtacg atatggaaag cggctttcaa gcgatggagc ggctgctggc actgccgaat 1182061 cctccaaccg ctgttttttg ttcgaatgat gacatggcaa tcggagcgat gaatgcgata 1182121 ttcgcaaagg gcctgcgcgt tcctgatgat atttcggtga tcgggtttga tgatattggg 1182181 ttttcacagt acatcacgcc aaggctttca acagtaaagc gcccagtgga gaaaataagc 1182241 gtgctcggtg cgcaaaaact cttgtcgctg atcagcgagc ccgaaacaaa agcagaaaaa 1182301 atcttggaaa acacagaatt tatggtgcgt gattcagtca gacgattgac gacgtgatgt 1182361 cccgtttttc agcgggcatt ctttatacag aaaaatgtta acgtgtgcat aaagtgagag 1182421 ggaggcaata agggtgcaga agctgaataa aaatgtgtac gatcactata ctcagtatcc 1182481 agaaaaaatt ctccaattcg gagaaggaaa ctttcttcgg ggatttatcg attggcagat 1182541 tgatcaattg aatcaacaca ctgattttaa tgggagcgtg gcagttgtcc agccaagagg 1182601 ctcagaaaaa atcaaacgat taaatgagca agatggatta tatacacttt ttttacaagg 1182661 aatgaaagac ggagaagcgg taaacgagca tatgattatc aactcaatca gccggggaat 1182721 tgacctgttt tctgattatg aagcatacaa agaattggca tcaagcgaaa ggcttcggtt 1182781 tattatctcc aacaccactg aggctgggat tgtatgtgat gaaaaagatc gtttagagga 1182841 taggccgcaa aaaacattcc ctgggaaatt aactgcattt ctttactttc gctatcaggc 1182901 ttttaaagga gatcagacaa aagggtgtgt cctgatccca tgtgaactga tcgagaataa 1182961 cggtgaaaag ctgagggaaa cggttcttca ttatgcacat ctgtggaagc tggaggaagg 1183021 atttacacag tggattcatg aggccaatac attttgtaat agtttagtag accggattgt 1183081 tccgggtttt cccgtcgaca gcattgatga gatcacggca gatcttggct atcaggatga 1183141 tttgatagtt gtgggagagc aatattattt gtgggttatc gaggggcctg attggattgg 1183201 aaaagaactt ccctttgcgg ctgcagggct gcatacaaag atcgtcagcg acctcacccc 1183261 ataccggact aaaaaagtaa gaattttaaa tggcgctcat acagcaatga cgccagtggc 1183321 tttattatac ggcttgaaga ctgttaggga tgcagtcgag catccggaag tggggcgatt 1183381 tataagagag ctgattgatg acgaaattct tcctgtttta aaaatggaag gtctttctca 1183441 gtatgctgac gatgtgctga accgttttaa aaacccgtat attaagcatt acctggaaag 1183501 cattgcattg aacgccattt ccaaattcaa aacgagaaac ctgccgactc ttaaggaata 1183561 tgctgaacaa aagggacagc ttcctgaacg cttggtgttt tctttcagcg ctcttctgta 1183621 tttttatcat gataacgaga cattgcagga tgatccggca gttcttcaat ttttcaaaga 1183681 ggtttggtgt caggaggatg gcgacatgct tcggattgca tcaagagtgt taggcgaaca 1183741 gcggctgtgg ggggcagatc tcaatgagat accgaagctg actgatagag tcgctgttta 1183801 cttgaatcat attcatgagc tgggcatgca gagggctctt gaacaatact gcatacaagg 1183861 gggagaggta cgttgaagtc gtttataaag attcataagc aagataatgt ccttcttgct 1183921 ctgcgggata ttcaaaaggg agagaggctg catgcttacg gcgtgtcgat tgaagtaaag 1183981 gatgatataa aaagaggcca taagattgca ttgcagtcta tcaaagaaaa cgacagcatc 1184041 gtcaagtacg ggtttccaat cggtcatgca tcacaagata tctcgatcgg agagcatatt 1184101 catgtccata atacgaaaac aaacctgtct gatatccaat tatacagcta tacaccgaga 1184161 tttgatgaaa atccgtattc taatgagaac cggacgttta aaggttttag aagagaaaac 1184221 ggagatgcgg gtgtacggaa tgaattgtgg attgtcccaa ctgtcggctg tgtcaatgga 1184281 atagcagaaa aaatgctgca gcgttttgtc agagaaacag gggatatcgc tccatttgat 1184341 aacgtactgg tgttaaagca tcaatacgga tgctcgcagc ttggcgacga tcatgaaaat 1184401 acgaagcaga tcctgctgaa tgccattcgc catccaaatg ccggcggcgt cttggtgtta 1184461 gggcttggct gtgaaaacaa tgagctggca agaatgaagg aagcactgca agatgtgaac 1184521 ttgaagcggg tgaagtttct ggaatcccag tcggtgaccg acgaaatgga ggcaggcgtt 1184581 gctttgctga aggaaattca tgaagcggcc aaaggagata agagagaaga cattccgctg 1184641 tctgaactga agatcgggct gaaatgcgga ggttcggacg gtttttccgg cataaccgca 1184701 aacccgctgc ttggacgttt ttcagattat ctcattgcac agggagggag tactgtgctg 1184761 acggaagtac cggaaatgtt cggcgcagaa accatcctga tgcagcgggc tgccaatgaa 1184821 gaagtgtttc ataagatagt cgatttaatc aatgatttca aacaatactt tattaaacat 1184881 gatcagccgg tgtacgaaaa tccttcaccg ggcaacaaag cgggcggcat ttctacactt 1184941 gaggataaat cgctgggctg tacgcaaaaa gcggggattt ctcctgtcac ggatgtcttg 1185001 aaatacggtg aagtactcaa gacaaaaggg ctgactcttt tgagcgcacc gggcaatgat 1185061 ttgatcgcct cctccgcatt ggcggctgcc ggctgccaaa ttgtcctctt tacaacggga 1185121 agaggcacgc cgtttggcac ctttgtcccg acggtgaaag tagcgacaaa caccgagctg 1185181 tatgaggcga agccgcattg gattgatttt aacgcaggcc ttttagcaga ggatgatgtt 1185241 catgaggaat atgtgctgcg tgagtttatc cactatatga ttgaggtggc aagcggccag 1185301 cttgtgaacc atgaaaaaaa tgatttcaaa gaactcgcca tttttaaatc gggtgtgacg 1185361 ttataataag aaaaggctat ccttcaagcg gatagccttc ttcattaaat caattttaaa 1185421 ccgctgacta aaataatgga agccataata aattgcagtg gacgcgggga gaatcgaggc 1185481 gaaagatggc tcccgatcag tacgccggga attgaaccga ggagcagatt agctgccagc 1185541 atgtaatcca cgcttccgaa gcttgcgttc aaaatgcctg ctgccgtaac aagaagaaaa 1185601 gcatgcgcga tatcggttcc gacaatctgt gacgctttca tgttaaataa gtaaatcatg 1185661 gcgattgcaa ataatgagcc ggacccgatt gatgttaatc cgacgataaa cccaaacaca 1185721 acaccaataa gaattgtcag cgccctctta ttttcaagcg gcatcagctg ccagcggttg 1185781 gggcgaagtt ttctatccaa aaacaaacga acgatgattg aaatggcaac cagcgttaac 1185841 acatatccta gagcgtgctt aataatttct tcctgatgct ggtgaaaggc ggggaacaaa 1185901 tgcaatatgc caatggctag cgaagcactc ggaataccgc cgatggctaa gtattttacc 1185961 aatttaaagt taatcgtttt ctgccgccaa tgggaggcaa cgccaaacag ctttgtgatc 1186021 gagttatata caagatccgt accgaccgcg atggaaggat taattccaag cacaattaaa 1186081 aggggagtta ataaggccgc tccacccact cccgtcaatc cgactaaggc tccgacaaac 1186141 aaacccatca atatgatgct tacactcatg ataaaggcct cctgaaaacc cgactagaat 1186201 tcacccgaat cttattcgcg ttggtcaagt attaattgta agtgctccat cggctgctga 1186261 aaaacccgag ctctatccgc tccctgatgg tatcattcaa ttgacaacac cttatacatc 1186321 aggagaacac gtctttcagg tgcaacgagc acttgcggct ctgtattttt accctgataa 1186381 aggcgctgtt aacaacggaa ttgacggcgt ttacggaccg aaaacagctg acgcagttgc 1186441 ccgttttcag tctgttaacg gtctaactgc tgacggtatc tacgggcctg cgacgaaaga 1186501 gaagatcgca gcgcaattaa gctgatcaaa gaccataaaa atcccggagc cgctccggga 1186561 tttatttttt cttcttcaac ttttttataa ttccagcact gcgctccctc acccgaagcg 1186621 agtacccgga aagcccaaac cttccgtaat caacaaactt cacacgcctc accaattttt 1186681 tcactgtatc acctgacatt atcctctgtt tgtatttatt atatgtcacc ctttaagaaa 1186741 aggaataagg acaagagctg ttttcccttg tccttttagt gtgatcatgc tttttttcgt 1186801 ttatactcgt caatcagccg ttcgttttct ttgaagattc ttgctgtatg cggactgact 1186861 tgatagcttg cgacactggt ggttgaacgt tttttcagga ttttaaacgg cttcgccgct 1186921 ctgggctcgc atctgttttg aaacgcacgt tccattatcc ttcaccttcc tcctcaattg 1186981 gcagcaccaa atcatatatg ctcgttaatg acgtaaatag caaataatca aattccgtga 1187041 caatgctgtc agacgtcagc ttgatgacat agttctgtgt ctcgatggta aaagggatga 1187101 gaaccacttt tccgtattgg tcgtaataaa catcctttcg atcgagccgt gtttgtacat 1187161 ctgccggatc atccatatgc tcggttaacc ggtctttatc agcctgtgtc gaatagtggc 1187221 aaagagaagc cgttaagttc attttatcag cataggtttt cagcagctta tcaatacctt 1187281 cagcataagc atctatactt ccataataaa catggatcgg ttcgtttttc aataggtatt 1187341 ggtatgtttt cagccgattg agatacatgt ggagcatttc gttgttttct tcaagaattt 1187401 ctcttgtgtc tgtttcaagc tcgctgccgg ccagtttttt gacatatgca cttaagaaga 1187461 taaaagcatc aatcaaagca aaactgactg cgacaatgag ataccgttcc cagtgggtaa 1187521 atagggaagt gggctcatat gtccagtata ccatagcgcc cagaacaaac agcaaatacc 1187581 aagttttccg aatggcggac attttttctt tgaccttcgc ttcgaaacgc cacgtggcat 1187641 acacgtataa ccccagtccg gccacgatgc accagaccat gatctgaaag aataaaacca 1187701 tattcgaatc cctcacatct gaaataggtt ctgcttattg tattcgagag atccggatgg 1187761 ttttcctgtt ccatcaaaaa aaccgctcct ttgacagaag cggtgtgaca ttaaaatatc 1187821 atatttaaaa taaagtaggc gatggcacca agtgtcgctg aaatcggaag cgtgatgacc 1187881 catgtaatga gcattcgctt ggccgtaccc cagtttacgc cttttacgcg gtgggacgca 1187941 ccgacgccaa gaattgatga agaaatgacg tgggttgtac tgaccggcaa atgaataaac 1188001 gtggcgccga aaataatggc tgctccggtt aagtcagcgg aaacaccgtt taccggacgg 1188061 attttcatga tctttccgcc aacggttttg atgattttcc agccgccgat tgatgttccg 1188121 agacccatgg ctgtcgcgca ggcgaattgc acccaggtag gaatatcatt agcagaagta 1188181 tgtaaattcg ctgtgatgag agccattgtg ataattccca ttgctttttg cgcatcgttt 1188241 gttccgtgtg tatacgattg cagggcagct gttacaatct gcactctgcg gaattgctta 1188301 ttcgttttcg ccaagttgct gtctttgaaa atcagcttaa cgatgctata aagaataaaa 1188361 ccaaggacaa aggcaataat tggtgataga atcagtgctt caatgatttt aatgaagccc 1188421 ttatagttta acgctgcaaa tccggctgcc gcaatggctg caccggcaat agcgccgatg 1188481 atggcatggg atgagctgct tgggataccg tagtaccatg tgataaggtt ccaggcaatt 1188541 gcagcgagta gcgcagccaa aatgacaaca gagccatttt ccagcgtata aggatctacg 1188601 atgtctttcg taatggtttt ggcaacacct gtaaacgtca ttgctccgac aaagttcatc 1188661 acagcagcca atataatggc atggcgcggt tttaacgctt ttgttgatac cgaagtcgca 1188721 attgcgtttg ccgtatcatg aaacccgttg atgaaatcaa acgccagagc acaaatgact 1188781 attagtatcg ttaatattaa tagaatatcc atttttaccc ctcgttacgc gtttttcata 1188841 atgatggttt caagattatt ggcaacactt tgacaagagt cggcgatttc ttcaagcgtt 1188901 tcgtatattt cacgatattg aatgactttg attggatctg tttcatttcc gaaaagattc 1188961 tttaatgatt ttctgtgcaa gttgtcacaa ctgtgctcat actctttaat tttgattgcg 1189021 tgaggctgaa tatcctttaa gcgattttct gccagcagct cgatcgtaat caaaatctct 1189081 ttcgcacatt ctctgatata tccgctgaat ttatcaatat gctcgtctga tgaagtaatt 1189141 gagaaaatct ccatcatggc agagaaatgt tcgattccgt caagcacatc atccaagctg 1189201 tttgtcagct gaaggatatc ttcgcgctca ataggagtga tgaacgcttt gttaagctct 1189261 ttaatcatga catgaacatg attgtcacct tttgtttcat attcctttaa cgtatctgca 1189321 aattctttaa gagtcgtttg gttagtgacc ttaaaattca caaaatattc tgcagtttcg 1189381 tctatgttct ttgcaatttc tgttaaaagg agtgagaact tatctttttt tcttcttatc 1189441 attaaaaacc ctccatagtt tgaatgaaca atgcacacat caaattatta tatagccttt 1189501 tgtcgaaaaa aaacaggtaa agtcgaaaaa aacgtatctt gacttttttg ataaatcgtg 1189561 tctccttatt ttgacctact tcgctttaaa aaaacgaccc aagtttgcaa aaactttctg 1189621 cttaacgtaa aaagtatatc aaaagttgtg tttttcctgt caacttttat cttctgtttc 1189681 accaaaaaac ggttccctaa acaagggaac cgttttatca gcttgctttt cgttttttca 1189741 tcccgtaata aacaggcagt ccggcaaggc cgatgaggat ggataatccg cagctcattg 1189801 tatctgtaat gagtgtgctg cctaacacaa agaaggagcc cgcgattgcc agaattggca 1189861 taaatggata aagcggaaca ctgtaggcgc gcttttctcc ctttgctcgc ttgcggagaa 1189921 taaacactgc aaaaaaggcc atcacataaa aaatgtagat catgaaaatg gagatttctg 1189981 agagcttatc agggttgctg atcagcatca taatcaaagc caaagcaatt tgaaaagaaa 1190041 tcgcaatcca tggtgtgcgg aacgacgggt gtacatgtga cagtttttca gcaaatggaa 1190101 gctgtttgcg ttccgccatt gcaaatgaaa cacgcgggaa agaaagcacc tttccattta 1190161 agcacccaaa gatgctgacg ataatcccta cactgatcag ctttccgcca attgaaccga 1190221 acagcatggt tgcagcggtg cttgtcgcat tttcaccaag cgtgacaatt tcgttcgctg 1190281 acaggatgtg aagcaatgca aaattaatga aaatatagat cgccgttaca attaataatc 1190341 cgcccgtcat agcgcgtggc agcagctttt cgggattttt catttctccg ccgagagcgg 1190401 caaggagaat ccatccgtca taagcaaaca acgtagctaa aatagccgcc ccgaagttca 1190461 tatcagaaat gctttcgttt actgctgtga agatgtgctg atcgcctttc caaaggccaa 1190521 agacgatgat gcaggcaatc ggaatcagtt ttccgatcgt tgtcagcgtt tggacaaaac 1190581 cgccgtattt tgtaccgata atattaatga cgcataaaaa gagaactgct ataattccaa 1190641 tgacttttga tagtccagat ccccagccga aaagattcgc cattaaagat ccaaaatata 1190701 aacccagcgc gccaataatc gccgggccgt aaatgataat ctgcacccag ccgcacaaaa 1190761 atccccaaaa ctcgccgtac acttcttcaa ggtacgtata aagcccgccg gtttttggaa 1190821 tctgcgttcc gatttccgcg attgtcaaac cgcccgccag tgttaaaata ccgcctaaca 1190881 gccaggcgaa aagcgccatt tttgaatcac ctgaataagc aagcacagcg ccgggcttca 1190941 taaaaacacc agaaccgata atggttccga tgacaagagt aagggcaaac aagaggccta 1191001 tctctttttt caaaccgttg tcttcagtat gcatgtcctt aacctcctat gatgttgaag 1191061 cttcatgttg aagaatctat tttttcatat tgtaaaccct attttagaaa agtgaaataa 1191121 aataaatttt ctgattttcg aaatttgctt tgtgtacagc agataaaact gtagaaatac 1191181 ctgttttaat ggtctataaa cgaataaaat tcataatttt tatttacaaa gttcgtgttt 1191241 tatgtattag gattttagcc ggtacagagg ggagatgaga attcagaaaa tgaacgaacc 1191301 ttcggtgaag ctgatatgtt gactttctca tgcgaataaa atactttgtt attagaacaa 1191361 taaatataca attatgatat gatatctcga aatcgagata aaataacctg gagggacagc 1191421 atatgaaagt taacggcatt caccacgtat cggcattaac ggccgacgca caaaaaaact 1191481 tggatttcta taagaaagta ttaggattaa agctcgtcaa aaaatccgtc aatcaggatg 1191541 aaccgacaat gtaccatctg ttctacggag atgaagtggc aaacccggga actgagctga 1191601 cgtttttcga gattccccgc attgcaccgt ttcatgcggg aacaaacagt atttcttcta 1191661 ttggattgcg cgttccaggc acagaagccc tgcattactg gaaagaacgt tttgaagagc 1191721 agcaagtaac gcacagcggc atctccaaaa gagccggacg tgacatattg gcatttcaag 1191781 atcatgaggg gcagcgactt gtgctgactg ctgatgagga aggaaaagga tatggcctgc 1191841 ctgttaaaca gagcggcatt ccggaagaat tttcgtttcg cgggttaggg ccggttgaac 1191901 tgactgtgcc atatgctgaa ccaactttac acgtattgac gaatattctt ggatttacag 1191961 aaatcagccg tgaaccagtc gaagggcaag gaaccgccgt tattctggaa tcaggagaag 1192021 gcggtgctgc aacggaaatc catttaatag aaagaaacga tcttccgcga gagcgtcaag 1192081 gcaaagggag tgttcaccac gtcgcatttc gggtaagaga tgaagaagaa cttgccgggt 1192141 ggcaccggat catcagccgc gaaggcttta gcaattcagg catagttgag cgctactatt 1192201 tcaaggcgct gtatttcaga gaaccgaacg gcattttgtt cgagttatca acagacggac 1192261 cgggctttat ggtagatgaa aatcttgatg agcttggcca aacgattgct cttccgccat 1192321 atctagagca tcgaagagca gaaattgaag caaaattgaa accgatccaa taaattgtga 1192381 ttcttttgcc ttccggcgcc gccggagggc tttttttatt accataatta attttgacct 1192441 aaacagcatg ccttattagg gaggaaatat cagatgctga ttgggagaaa tggcttaaaa 1192501 ccctttgcaa atatgggtga ttggtatgga atggcctcgg caaaaatatt gtctttgttt 1192561 attaatagtt tattcatatt tgcttgttac actatttcaa agttagacaa aaaggagtga 1192621 aaaataagtg gaaaagaaaa aacgcgagct ggatatcgtc ctcctcctca ttttgctcgc 1192681 atctgcattc ttaaatatct ataacatttg gaaggacgac acggtgaatc cttattacac 1192741 cgcggcagtt acaagtatga tgcaaagctt tcataatttc ttttatgctt cgttcgatgc 1192801 tgccggcttt ataacagtag ataaaccgcc tgttacatac caaatccaaa cgatcagcgc 1192861 actgatattc ggtatgcacg gctggagcgt catcctgcct caggcacttg ctggtgtagg 1192921 ttctgtcctt cttatgtact tgctgataaa gccgacattt ggaaaaacgg cggcgcgtat 1192981 tgcctcattt gttatggcat gtacgccgat agctgtagct gtagcacgta caaacaatgt 1193041 tgatgcatta ctggtatttt tcttattgct tgctacatgg cttctcttta aagcgatcag 1193101 aaaaggaaag ctgatctggc tgttagcagc atttttcgtt gttggagtag gttttaatac 1193161 aaaaatgctg caggcttaca tgattttacc ggctttctta ttgttctatc tgattgcggc 1193221 aaacgccaca atcaagaaaa aaatcgtttc attggtaagt gcgttagccg tattagcagc 1193281 cgtttcgtta tcgtggccgc tcattgttga caatatccct gcaagcaagc ggccttatat 1193341 cggaagcagc caaaccaact ctgttttgga attggctttc ggctataacg gaatccagcg 1193401 gctgacaggc caaaattcag gcggcggcca gggtgcgcca aacaaagacg cttcaaaaga 1193461 aatgtcttct tctgataaca ctcaagcacc gcctaatcag tcatcaagca acagctcatc 1193521 aagcgatggt aaatcctcaa atggcaatat ggcggcgcct ccatccaatg gccaaatgcc 1193581 aagcggcggt caaggaggcc ctccaagcgg cggagatggc ggccaaggcg gacccggcgg 1193641 agacggaggg aaaggcggta caggaaccgg ttcgaaaatg caatcaggtt cagggatgtt 1193701 tggaacggga acacctggtc cactgcggct tttccaacaa gagttatctg atcaaatcag 1193761 ctggcttctg ccatttgcga tatttggaat cgcaggctta ctgatcgctg gcgcaagaga 1193821 aagaagaaga ttatctgtag agcagaagga aacggtgttc tgggttgcgt ggcttgtacc 1193881 gattgccgga ttcttcagtg tcgcagaatt tttccatcat tattatctca tcatgctggc 1193941 accgccgatt gcggctcttg tcggtgcggg gtgggtcgct cttgttcatc tgtaccgcaa 1194001 tcagacaggc tggaaagcat ggcttttgcc gggagcaatt attgcgacaa ctggatttga 1194061 attgtttatt ctcagaaact acaacgatca aatcggtgtt ggatggagta tcggggtagg 1194121 tgttatcggc gtgttgtcag cgattgcttt gctgctgttt aaacagcgcc aaaaaccgtt 1194181 cagttattat gtttcacttg cagctctcct cgcattgctg gtgatgccga tgtattgggc 1194241 aagtacaccg cttctgtacg gaggcaacag ctcactgcct gaaacaggcc ctcaactcgc 1194301 atcaatgagc ggaaaaggca tgggaatgtc tgatgcgact gtaaatgaaa aactgatcaa 1194361 atatctagag gagaataact ccggagctga atacctattc gccacaaccg attcgaacac 1194421 agcggcacca tatatcatta aaacgaaaaa agctgtcatg gctattggtg gatacagcgg 1194481 ttctgacccg gcaatcacac tgactcaatt caaaaaactt gtaaaagaag gaaaagtgaa 1194541 atacttcttg gcttctggaa tgggaagagg cggaaacaat gacattgttg aatgggttga 1194601 gaaaaatgga aaagaagtag catcagaaaa atggcaatca agttctgatc aaaaaacaga 1194661 aaatactgat tcagctgata catcaagcag caaggcttca ggtgaaaacg gcaaaatggg 1194721 cggacctggc ggaatgaatc agtcagcaac attatacgaa ctacatgctg atgaatagga 1194781 ggcaaaaaca tgagcagaca tattcaatat tcaattgttg tacctgtgta taatgaagag 1194841 cttgtcattc atgaaaccta tcagcgctta aaagaggtca tggatcaaac gaaggaaaac 1194901 tacgagctgc tttttgtcaa cgatggcagc aaagaccgca gtattgagat tttaagagag 1194961 cacagcctga tcgatccgag agtgaaaatt attgattttt caaggaattt tggacatcag 1195021 atcgccatta cggcaggtat ggattatgca caggggaatg caatcgtcgt cattgacgcc 1195081 gatttgcagg accctcctga actgatttta gaaatgattg aaaagtggaa ggaaggctat 1195141 gaagtcgtgt acgccgtacg gactaaacga aaaggggaaa cctttttcaa aaaacaaacc 1195201 gcggctatgt tttaccggct tctcagcggt atgacagata ttgatatccc gattgatacg 1195261 ggggattttc gcctcatgga cagaaaagtc tgtgatgaaa tgaagagatt aaaagaaaaa 1195321 aatccatttg taagagggct agtcagctgg gtgggtttca aacagacagc ggtcgagtat 1195381 gtacgtgatg aaaggctcgc cggagaaaca aagtacccgc tcaagaaaat gctgaagctg 1195441 tcaatggacg gcatcacgac attttcacat aaaccgctga agctggcaag ctatgcgggg 1195501 attttaatgt caggtactgg atttctgtat atgtttatcg tgctgtatct gaagctattc 1195561 acagacagca cgattaccgg ctggtcatca cttattgtga tccagctcct gttcagcggc 1195621 attgtccttc tgattttggg cgtgattggc gaatatatcg gcagaatcta cgatgaagcc 1195681 aaagacaggc cgctttacat cgtccaaaaa tcgtatggaa ttgaaaataa aagactctat 1195741 agagaccagc atatgtcata acctcaaacc ccctgtccgt aatggacagg gggtttttat 1195801 gctctgagca cgatctaaag caaaagatgc tgatagatat atggaaattg ggtaaagaag 1195861 agattgtgag cttgtactgc ggttcagtca tgctgaaata aaaacagcaa aacttaaaga 1195921 tttcgtcctc ggctttgctg catgtcagct gttatattgg ggggctttta agaaacgcat 1195981 gattagagcc gtaccagtta tgtttaatag aatactcgta cccaatacaa ttccccacgt 1196041 caacgtcgat tcagagagaa gaaagctcag caaaagaaaa gccaatcctg cgcagatcat 1196101 acccagtccc acggttttca tgttcatgcc tcctagcaaa cgatgtttct agcatctgat 1196161 gtgaatgatg tcaatctgta tgatatacgg atatctcgtc agaaagtttc atagaacaat 1196221 taggtctttt atctaataaa aagcctcaga ccgcttttac ggcctgaggc attatgtctt 1196281 acgaagtttt ctcttctttt tgatccagtt taattttttt cgtcatttct ttgccgtttc 1196341 ggagaatttt cacttcaacg gtatcaccga tctttgcgtc tttatataag atattgcgca 1196401 attcactgcc tgtatcaatt tctttacctt ttaggccgat gataatatcc tccgctttta 1196461 atccggcctt ttcagcagga gagcctgaag cgacctcacg gatgtaaacg cctttattca 1196521 gctggctgcc gaacaggccg agtgtgcctt cttggtaatt ttgcggcact tgctctagat 1196581 caagcatgct gacaccgata tatggacgtt caatttgtcc tttagacagc aattcttcag 1196641 caatcggttt tacgtcattg cttggaatgg cgaatccgat accctcaaca tcatcctcac 1196701 tgattttcat actgttaatg ccgacaattt tgccgtctgt atttaacaaa ggaccgccgc 1196761 tgttacctgg attaattgct gcgtctgtct gaatgacgtt aatgctcgtt tcgccggctg 1196821 atgtagacat tgaaaccgtt ctgtccacgc cgcttacaat tccttgtgtt actgtgcggg 1196881 acaggtcttt tccaagcgga tccccaatcg caataacggt ctcgcctgtt ctaagatcag 1196941 atgaatcacc gaagtttgcc acttttgtga cgtggtcatc actgatttgg aggacggcta 1197001 aatcagttaa cgagtcactg cctaccagct ttgcagtaac ctcagtgccg tcatataaag 1197061 ataccttcag tgatgatgcc ccttctacga cgtggttatt tgtaatgata taagccttgc 1197121 cattctcttt tttgaaaatg acacctgacc ctgaaccgct ttctgtatct tcgctggaat 1197181 cagaagaact agagccgaac aaagagctgt ttgattgtgc ctgaagattt gtaataccga 1197241 caatcgctgg tgaaaggtct tctaccatat ctgagatttt agaagagtcc tcgctcttga 1197301 atgcagatga gctgcttgag ctttttttag attcagagga ggtgcttgtt gctgtaacag 1197361 attgcgtttg ctgctggctg gatgattgtt ttgcagtgtc ctgagaatca tggtcaccaa 1197421 gcggtgtaaa cgtgtaaatg ccaagagcaa gactgccgcc gatcactccg ccaagcaacg 1197481 gtctgaacca tccgaatcct cgttttttct tctcctgatc atgaatgaca ttgcgggccg 1197541 agtaggaggc gctctgatcg ttctctttcg ttaaaaagac ctcattctca ttacctttcg 1197601 ttctgttttc atcacgatag ttatccatca tgttcactcc gtttctctat tttcacatgt 1197661 ctatttatat tgataggttt atgacttgag tttatcataa acaaaaactg tgggataaaa 1197721 atgaaaagat tatgggaaat tgtgaaaaag tgcggaaaac ggtacacttc atattgtata 1197781 tgaaaggact gagtcgatgg aacagattgg attgattgga tatggcagca tggcggatat 1197841 gatcgctaga cagctgttga aacatgaaca aataaaagag aatgagctat ttattgagac 1197901 gagaacgaag ggggagcggc tgcgggcact catgtcagat tatccaaacg tatcggctga 1197961 tccgttggag aattgggcaa atacgtgcca attgattttg atatgcgtcc cgccactcca 1198021 tgtcatcgaa acaatgcgcc gtctgtaccc gtatgtgaac agaaatactc acatcgtatc 1198081 catagctgcc ggtgtgccgc tgcgtctttt ggaggcagaa acagaagccg gtatctcacg 1198141 tgttattcct gccattacgt ccgaagcaga agccggcatc tcacttgtcg ttcacagtga 1198201 agcactggct gcagagaaaa aagaacgtct gaatgaattg ttatcggttt tcagccgtgt 1198261 acgggaaatc aaagaatcga atttagatgt ggccagcaat ttaacgagct cggcaccggg 1198321 attcatagct gcaatctttg aagaactggc actgtctgcc gtcagaaaca gcagcctgtc 1198381 caaagaagaa gcctttgatt ttctgattca ttcgctatac ggaactggca agatgctgat 1198441 cgaaaaaaat atgtctttcg aggagacgct ggaacgtgtt gcaaccaaag gcggaataac 1198501 gggagaggga gctgaggtga tacacgcctc tgtgccggac gtttttgatg aggtatttga 1198561 aagaaccctg agaaaatatg aactgcttac agaacaggtt ggtaaacaaa catgaatcct 1198621 tgaaagagga ttcttttttt atcactgaat gattgagatt tttcccagtt atattgcatt 1198681 tttcctcttt ttttaatata atttgttaga atattcataa tttagtaaaa aaggaggagc 1198741 gttatgaaat tgtacatgtc agtagatatg gaaggtattt cgggtcttcc ggacgatacc 1198801 tttgtggatt ccggcaagcg gaattatgaa cgcggacggc ttatcatgac tgaagaagca 1198861 aactactgta ttgctgaagc gtttaacagc gggtgtaccg aggtgctggt caatgacagt 1198921 cattcgaaga tgaataatct gatggttgaa aagcttcacc ctgaagcaga cttgatttct 1198981 ggtgacgtca aaccattttc aatggtggag ggactggatg atacgtttag aggcgctttg 1199041 tttctcggtt atcatgcgag agcctcgact cctggtgtca tgtcacacag catgattttc 1199101 ggcgtccgtc atttttacat aaacgatcgg cctgtcggtg agcttggatt aaatgcatac 1199161 gttgccggtt attatgatgt cccggtatta atggtagccg gggatgaccg ggcggcgaag 1199221 gaagcagaag agcttatccc gaacgtgacg acagccgcag tcaaacaaac catttcaaga 1199281 tccgcagtga agtgcttgtc gcctgcgaaa gccggacggc tgttgacaga aaaaaccgca 1199341 tttgccctgc aaaacaagga caaagtcaag ccgctcacac cgcctgacag gccagttctg 1199401 agcattgaat tcgccaatta tggccaagca gaatgggcga atctgatgcc gggaacggaa 1199461 atcaagacgg gaactacaac cgttcaattt caggcgaagg acatgcttga agcctatcag 1199521 gcgatgcttg tcatgactga gcttgcgatg cggacatcat tctgctaaag gggtgtttta 1199581 ggctttggcg cgatacatga taaagcgttt ttgggcaatg gcagctacga ttttggtgat 1199641 taccaccctg acttttgttc tcatgaaggt cattcccgga tctcctttta acgaggagag 1199701 aggcacaaat gaagccgttc aaaaaaatct cgaagcctac tatcacttag acgatcctct 1199761 cattttccaa tacattttct acttaaaatc catcattaca ttcgatttcg gaccttcaat 1199821 taaaaaaccg tcggacagcg taaatgatat gctggaacgc ggatttcccg tttcctttga 1199881 gcttgggatg acagcgattg tcattgctgt gatttctggg ctggtgctgg gcgtaatcgc 1199941 tgcactccgc cgcaatggct ttttggacta cgccgcgatg agtcttgcag tactcggcat 1200001 ctccatcccg aattttattc tggcaacatt gctcattcag caatttgctg tcaatctcaa 1200061 actatttccc gctgcgacat ggacgagccc gattcatatg gtgcttccga ccgcagcgct 1200121 tgctgtaggg ccaatggcga tcattgccag gctgacacgg tcgagcatgg tcgaagttct 1200181 gacacaggat tatatccgca cagcaaaagc aaaagggctt tctccgttca aaattatcgt 1200241 aaaacacgca ctcagaaatg cactcatgcc cgtcattacc gtcctgggca cactcgtcgc 1200301 cagcatctta acaggaagct ttgtcattga aaaaatcttt gccattccgg gaatgggaaa 1200361 atattttgtt gaaagcatta atcagcggga ctaccccgtg attatgggaa cgaccgtttt 1200421 ttacagcgtc attctgatta tcatgctgtt tttggtcgat ttggcctacg gtctcttaga 1200481 cccgcgcatt aaactgcata agaaagggtg aagcgtgtga atctccctgt acaaacggat 1200541 gaacgccagc cagaacagca caatcaggtg cctgatgagt ggtttgtctt gaatcaggaa 1200601 aaaaatcggg aagccgattc ggtcaagcgg ccgagtttgt catacacgca ggatgcctgg 1200661 aggaggctga aaaaaaataa attagcgatg gccggactct ttattctttt atttcttttt 1200721 gtcatggcag ttatcgggcc ctttttatcg ccccatagtg tcgtacgcca atcgctgaca 1200781 gaacaaaatc ttccgccctc agccgatcat tggttcggca ccgatgaact cggccgggat 1200841 gtgtttaccc gaacatggta tggcgcgaga atctcgttgt ttgtcggcgt gatggcagca 1200901 ctgattgatt ttttgatcgg tgtcatttac ggaggcgttg ccggctataa aggcggcagg 1200961 attgacagca ttatgatgcg gattatcgaa gtgctgtacg gactgccgta tctgcttgtt 1201021 gtcattttgc tgatggtgct catgggaccg ggactgggca cgattattgt ggcgctgact 1201081 gtgaccgggt gggtcggcat ggcgagaatt gtaagaggcc aggtgcttca gattaaaaat 1201141 tatgaatatg tactcgcctc gaaaaccttt ggcgcgaaaa cctttcgcat catccggaag 1201201 aatttgctgc cgaatactat gggagcgatc atcgtacaaa tgacattaac cgtacctgcc 1201261 gccatattcg cagaatcatt tttaagcttt ctcggcctgg gcatacaggc tccgtttgca 1201321 agttggggcg tgatggcgaa tgacggcctg cctacgattt tatctgggca ttggtggcgc 1201381 ctgttttttc cggccttttt catatctctg acgatgtacg cgtttaatgt gctgggggac 1201441 ggattgcagg atgcgcttga ccctaagctg aggaggtagc tgtatggaaa aagttctgtc 1201501 agtccaaaat ctgcacgtgt cttttacgac ttacggcggg acggttcagg cggtcagagg 1201561 ggtgagcttt gatttgtata aaggagaaac ctttgcgatc gtcggcgaat ccggctgcgg 1201621 caaaagcgtt acctcccaaa gcatcatggg cctgcttccg ccttattcgg cgaaggtgac 1201681 agacggcagg attctattta aaaacaaaga cctttgccgt ctctctgaca aagaaatgag 1201741 aggtataagg ggagccgaca tttctatgat ttttcaagac ccgatgacgg cgttaaaccc 1201801 tacgctgact gtcggcgacc agctggggga agcgctattg cgccacaaaa aaatgagcaa 1201861 aaaagcggca cggaaagagg tgctttccat gctgtcattg gttggtattc cagatcccgg 1201921 agagcgccta aagcaatatc cccaccaatt cagcggcggt atgagacagc ggattgtcat 1201981 tgcgatggcg ctgatttgcg agcctgatat cttaattgcg gatgaaccga ccaccgccct 1202041 ggatgtaacc attcaggcac agattttaga gctgtttaaa gagattcaga gaaaaacgga 1202101 tgtgtctgtc attctgatta cgcacgattt aggggttgtt gcccaggtag ctgacagagt 1202161 cgcagtcatg tatgccggga aaatggcgga aatcggcaca agaaaagata ttttttatca 1202221 gccgcagcac ccatatacaa aaggcctgct gggctctgtc ccgcggctgg atttaaatgg 1202281 cgctgagctg accccgattg acggaacgcc gccggattta ttttcgcctc cgccgggctg 1202341 cccgtttgcc gcccgctgtc cgaacaggat ggttgtgtgt gacagggtgt acccgggcca 1202401 gacgatcaga tctgactcgc acaccgtcaa ctgctggctg caggatcaac gagcagagca 1202461 tgcggtgctg tcaggagatg cgaaggattg aacatgaaaa gggggaagag gatgaaacga 1202521 gtgaaaaagc tatggggcat gggtcttgca ttaggacttt cgtttgcgct gatggggtgc 1202581 acagcaaatg aacaggccgg aaaagaaggc agtcatgata aggcaaaaac cagcggagaa 1202641 aaggtgctgt atgtaaataa tgaaaatgaa ccgacttcat tcgatccgcc gatcggcttt 1202701 aataatgtgt catggcagcc gttaaataac atcatggagg ggctgacgcg tcttggcaaa 1202761 gatcatgagc ccgagccggc aatggcggag aaatggtctg tttcgaaaga taataaaact 1202821 tacacattta cgattcggga aaatgcgaaa tggacaaacg gagatcctgt aacagccgga 1202881 gacttcgaat acgcgtggaa gcggatgctt gatccgaaaa aaggcgcttc atcggcattc 1202941 ctaggttatt ttattgaagg cggcgaagca tataacagcg ggaaagggaa aaaagacgat 1203001 gtgaaggtga cggcaaagga tgatcgaacc cttgaagtta cactggaagc accgcaaaaa 1203061 tatttcctga gcgttgtgtc caatcccgcg tatttcccgg taaatgaaaa ggtcgataaa 1203121 gacaatccaa agtggtttgc tgagtcggat acatttgtcg gaaacggccc gtttaagctg 1203181 acggaatgga agcatgatga cagcatcaca atggagaaaa gcgacacgta ttgggataag 1203241 gatacagtga agcttgataa ggtgaaatgg gcgatggtca gtgacagaaa tacagattac 1203301 cagatgtttc aatcagggga acttgatacc gcttatgtcc ctgctgagct gagtgatcag 1203361 ctgcttgatc aggataacgt caatattgtt gaccaggcgg gtctctattt ctatcgattt 1203421 aatgtcaaca tggagccgtt ccaaaatgaa aacatcagaa aagcctttgc gatggctgtg 1203481 gatcaagagg aaattgtaaa gtacgtcacg aaaaataatg aaaaaccggc gcacgccttt 1203541 gtatcgcctg ggtttacgca gcctgacggc aaagatttcc gtgaagcagg cggagacctg 1203601 atcaagccta acgaaagcaa agcgaagcag ctgctcgaaa agggcatgaa ggaagaaaac 1203661 tataataagc ttcctgcgat cacgcttact tacagcacaa agccggagca taaaaagatt 1203721 gccgaagcta ttcagcaaaa attgaaaaat agccttggag tcgatgtgaa gctggccaat 1203781 atggaatgga acgtattttt agaggatcaa aaagcgctga aattccaatt ctctcaaagc 1203841 tcatttttgc ctgattatgc agaccctatc agttttctgg aagcctttca aacgggaaat 1203901 tcgatgaacc gcacaggctg ggccaataaa gaatacgatc agctgatcaa acaggcgaaa 1203961 aacgaagccg atgaaaaaac acggttctct cttatgcatc aagctgaaga gctgctcatc 1204021 aatgaagcgc cgatcattcc ggtttatttt tataatcagg ttcacctgca aaatgaacaa 1204081 gtaaaaggaa ttgtccgtca ccctgtcggc tatatcgatt taaaatgggc agataaaaac 1204141 tgatggaggc gattgaggaa atactgcttc tttatgcgaa ggagcggtat tttttctctt 1204201 tcttgcacgt atacgtaggg tgcagagcaa atgaaaggag tgttttcgtt gaattacaag 1204261 ccgaaagcgt tgaacaaggg tgatacagtc ggagtgatcg cgcccgcaag tccgccggat 1204321 ccaaaaaagc ttgacaccgc gcttttattt ttagaagagc tcggtcttca ggtgaagttg 1204381 ggcaaggcgc tgaaaaacca gcacggctat ttagcgggac aggatgatga gcggctggcg 1204441 gatctccatg agatgttcag agacgatgag gtaaaagcag tgttgtgcgc atgcgggggt 1204501 tttgggacag gacgtatcgc cgcgggcatt gatttcagct tgatccgcaa acaccctaaa 1204561 atcttttggg gatacagcga tattacgttt ttacatactg ccattcatca aaacacaggt 1204621 cttgtcactt tccatggccc gatgctcagc acggatattg gccttgacga cgttcacccg 1204681 ctgacaaaag cgtcatataa gcagctcttc caggagacgg aattcaccta tacagaagag 1204741 ctttctccgc tgaccgagct tgttcctgga aaagcggaag gcgagcttgt cgggggaaat 1204801 ctgtctttgc tgacgtctac actgggcacg ccatttgaaa ttgatacgag aggaaagctt 1204861 ctgtttattg aagatattga cgaggagcct tatcaaatcg accggatgct gaatcagctg 1204921 aaaatggggg ggaagctgac ggacgcggcg ggaattctag tttgtgattt tcacaattgt 1204981 gtcccggtga agcgagagaa gtctctctcg cttgagcagg tgctggaaga ctatattatt 1205041 tctgcgggca ggcctgctct gagaggattt aaaatcggcc actgctcgcc aagtattgcc 1205101 gttccgatcg gtgcgaaagc tgctatgaat acagcagaaa aaacagccgt aatagaggcg 1205161 ggcgtttcag aaggggcgct gaagacatga aaatcattcg aatcgaaaca agccgaatcg 1205221 ctgtcccgct gacaaagccg tttaaaaccg cacttcgcac tgtgtatacg gctgaatcag 1205281 tcatagtaag gattacttat gacagcggtg cagtcggatg gggagaagca cccccgacgt 1205341 tagtgattac aggagacagc atggatagca ttgaaagtgc catccaccat gtgttgaagc 1205401 cggcattgct tggaaaaagc ctggcgggct atgaggccat tctgcacgac atccagcatc 1205461 ttcttacagg aaatatgagc gcgaaggctg ctgtagaaat ggctctatac gacggctggg 1205521 cgcagatgtg cgggctgccg ctttatcaaa tgcttggcgg atatcgagat acgctggaaa 1205581 cagattatac tgtcagtgtc aactcacctg aagagatggc agctgatgcc gagaattatc 1205641 tcaaacaagg ctttcaaacg ctgaaaataa aggtcggaaa agatgatatt gcaacagata 1205701 tcgcccgtat ccaggaaatc agaaaacgtg tcggatcagc tgtgaaactg cgtttagacg 1205761 ctaatcaggg gtggaggccg aaggaagcgg taactgccat tcggaaaatg gaggatgcgg 1205821 gcctaggcat tgagcttgtc gagcagcctg tccataaaga tgatctcgct gggcttaaaa 1205881 aggtgacaga tgcaacagat acgccgatta tggctgatga aagtgttttt acaccgcgcc 1205941 aggcgttcga agttctgcaa acccggagcg cagacttgat caatattaaa ttgatgaaag 1206001 cgggcggcat cagcggagca gagaaaatta atgccatggc ggaggcctgc ggggtggagt 1206061 gtatggtcgg cagcatgatc gaaacgaagc tgggcattac ggccgcggcg cattttgcgg 1206121 caagcaagag aaacatcaca cgctttgatt ttgacgcgcc gctgatgctg aaaacagatg 1206181 tattcaatgg cggcataaca tatagcggca gcacgatttc gatgcctggc aaaccgggcc 1206241 tcggaatcat cggggctgcg cttttgaaag gggaaaaaga gcaatgatgc acactgtcat 1206301 atcagcagtg gccaacatct ggacagcgcc tgattcacct cgtccgtctg atcaattcat 1206361 gcttcaaccg actgtaatga tcagagactg gctggagcgc atgacgtatg atgaacggct 1206421 tggattatgt acagacaatg taatccaaac tcaggttctc tttggcgaaa aggtacttgt 1206481 gacggcggaa cagggggaat gggtttctgt gatcgtgcct agccagccat cccgaaagga 1206541 tccgcgcgga tacccgggct ggatgaaaaa gtaccagctg gaaaaaacaa agcccatcca 1206601 tacacaacac gatgtgatga tcagcaaacc tgctgccttt ttgtacagaa gcaatgggga 1206661 aaaggagatc gaattaagct ttttgacagt tctgcccctt attgcaaaag aaaacggata 1206721 ttttaaggtt tcgaccgttt ttggggaaag gtttgtgagg caaagtgatg cagtgcctgt 1206781 cagccaacag aaagggactg ctgaagacat cattcaaacg ggtgcgtttt ttcttggcct 1206841 tccctacctg tggggaggga tcagcgggtt tgggtttgat tgctccggat ttatgtacag 1206901 tatatttaag gcgaatggat acagcatccc ccgtgatgcg ggagatcagg ctaaggcagg 1206961 gaagggtgtc ccgcttgatg atatgaaagc cggtgatctg ctgttttttg cttatgagga 1207021 aggaaaagga gcgattcatc acgtcggtct gtatgtaggc ggcgggaaaa tgcttcattc 1207081 tccaaagaca gggaagtcaa tcgaaatcct cacattaaca gagacaatct atgaaaaaga 1207141 attatgtgcg gtgcgccgct gtttttcaga ataaggaggg agacaaatga ggcgactgcc 1207201 tttgttagag gtcagccagc tgaaaatgca ttttgacgca gggaaaaagc ggacagtcaa 1207261 agctgtcgac ggggtcacct ttcagattcg tgaaggagaa acgttcgggc tagtcgggga 1207321 atcagggtgc gggaaatcaa ccttggggag agtgctgatg cgcctttatc agccgacaga 1207381 aggaagcgtg acataccgcg gcacaaatct tcatgcacta agtgaaaaag agcagtttgc 1207441 cttcaaccgc aaactgcaga tgatttttca ggacccttat gcttcactta acccgcgcat 1207501 gaccgttcga gaaattattt tggagccgat ggagattcat aatctctaca atacccataa 1207561 agcacggctt ctcgtcgtgg acgagctgct tgaggcagtt gggcttcacc ccgattttgg 1207621 cagccgttat ccgcatgaat tcagcggcgg gcaaaggcag agaatcggga ttgcgagagc 1207681 actgtcgctg aatcctgaat ttatcgtggc ggacgaaccg atttctgcac ttgatgtctc 1207741 tgttcaagcg caggtggtca acctgctgaa gcggcttcaa aaagagaaag ggcttacgtt 1207801 tttattcatt gcccatgatc tttcgatggt gaagcatatc agtgacagga tcggtgttat 1207861 gtacttagga cacatgatgg aaattacaga gagcggcacc ttgtatcgtg aaccgctcca 1207921 tccctataca aaggcgcttt tgtcctcgat tccgattcca gatcctgaat tggaggacaa 1207981 gcgtgagcgt attctcttga aaggggagct gccgagcccg gtcaatccgc caagcggctg 1208041 cgtgtttcgt acccgctgtc cggaggcgat gcctgaatgt ggagaatctc gtccccagct 1208101 tcaagaaatc gaacccggcc gttttgtcgc ttgccatttg tatcgaaatg ctgaaacgaa 1208161 ggaaaaagta agataaataa aaagagtggc tcctttttac tagagccact ccatttgttt 1208221 atacttgatg taaaaacttt acacaaaccg ggtaagggac agaaaccgtt gatgggagga 1208281 gtgtcaatcg gccggtttct ttgtctcttt caaacaagac aaggttgcct gtttcttcat 1208341 ttgaagcaac gaggaaccct tccgttgggt caaatacaaa gtcacgaggc cagtttcctt 1208401 ctgtcgacac tctttctacg aaagccagct ctcctgaata ttgattcact tcaaatacgg 1208461 cgatactgtc atggccgcgg tttgcgacat aaacaaaacg tccgtcctgc gtgacatgta 1208521 ttgcgcttcc ctggctgtta tctgtaaaat catcagggat ggcagaaacg acttggattt 1208581 ctctaaattc gccggctgtc gggttgtatt caagcgcaat cacttcattg cttaattctg 1208641 tcatgacata agcgtatttt tctttcggat gaaaagcgat atggcgaggt cctgcaccgg 1208701 gagcgaagga atggcttccg gattcagtca acacaccgtc tttaagctta taggtgtaga 1208761 gcttatctat acctaaatca accgctacca cataattgtg ttcaggtgtg aaccccgcgt 1208821 agtgtgtatg cggtttttct tgtctttcgt gcggcccttt tcctgtgtga gcggcctctg 1208881 aaacaggtga ttgcaagctg ccgtcttcct gaaccggaaa aacgtgtacc ttcccgctgt 1208941 gataattggc agtcagtacg aattgatttt gatcatcaac gcttacgtgg catggcgaag 1209001 ggccatcaat taactgatga ttcagaaatg tcaattcgcc gctgttttta tcgatttgat 1209061 aggcagcaac tccgccttgg ccgtctgctt tttcgatgga ataaaggatg gtgttgtttt 1209121 tattcgtcgc cacatatgtc gggttgccca gcttagcggc cagctttggc tcgctgagtg 1209181 cttttttctc agtatcaagc tcaaatgaat aaattccttc gcttccgcct tttgtatatg 1209241 ttcccacata tcctatgtat tttgtcatgc gatttccccc ttaaaaatga tgtcacctct 1209301 atattaacgt atcttgataa aataagctgt tcaaaacatg aaaaagggga agattcttca 1209361 ttcgcctcga atcagcggca ttgtgcagca cctgaaggag ccgcctgatt taataatttc 1209421 tgacaggtca atttcgataa tgtgatagcc tcttttcgat agctgttgat tgacatggcg 1209481 gttgccaggg agactgatga tcgttttttt tccgattgaa aggacgttgg tgccaagcgt 1209541 aaattgttcg tcctcgggca cctcaataag atcataacgt tttgccagca tatcggctgc 1209601 atctggctca atggcctgtg aataaattaa cgcttcgctt tcagatataa tgttaaatac 1209661 gcagtccaaa tgcaaaaatt tttcatgaag cttcactgga acgatcgtat attcaggaag 1209721 tgcctcttct agctggccga tagctgaaat gtcggtgcgc tggctgattc cgacatagac 1209781 aatgtcatca tcgataatga cgtctccgcc ttcaatactc gtatcaagca tgcgggtgta 1209841 agagatacct tggctgtgaa aaaaatcttt tataacggct tcttctcctt ggcgaatcgg 1209901 ttcagtcatg cttgacagaa aggctttttc tccgatgaca aatcctatgt ccctagtaaa 1209961 aacctgttct gggagtccgt cgcgaacggg caaaaggacg acctcaacgt tgtgtgacct 1210021 aagtgcctcc actaagcggc tgtgctggtc gttagcggtt tttacatgaa tattgtcatc 1210081 ttcaaaatgt ttttgtgttt cgtttataac atcttttatg gtcatgtgct caggtttgca 1210141 taagatcact ttttgaagtg tgccgtattc cgttcggcat accgttttgt gctgagattt 1210201 cgggatggat acgtccattt gtttttcctc ctaaagtgtg aagaatacat ttattattcc 1210261 ctcatcatga aaatcattaa accattttaa attttagaca aatggaagag aatattgttt 1210321 aataggagaa tataagtgca tttagctaaa agatcagaca tcaaagggga gaaaggtatg 1210381 gaaacaccgg aaacaagatt ttgtaaagag tcaaaggttg tgaaaaccag cagggtgttc 1210441 ccgcttgaca cgaacaacca taatacgctg tttggcggaa aattaatgag ctacatagac 1210501 gacattgcct ctatttcagc ggcgcgccat tgcagacgtg aaacggtaac agcttcaatg 1210561 gattctgtag attttttaaa gccgatcggg caaaaggatt ctgtctgcct agagtcatat 1210621 gtgacatggg tcggcacatc ttccatggaa gtatttgtga aagttattaa ggagcatttg 1210681 atgactggcg aacgggaact cgctgccaca tcctttttga catttgtcgc attagattca 1210741 aatggcaagc cggtgcctgt accgagggtt gtaccggaaa cagaagaaga aatcatgctg 1210801 cataatacag ctgtacagcg tgctaatgaa cgtaagaacc gcaagagaca cagccaggcg 1210861 cttgcaaatg cgctcggaac tgataagcct tggtgaacgt taaacccaaa acataagttg 1210921 ttttgggttt ttttgtactt ttcaatggtg attattacaa tggttagtcc gtttttgcta 1210981 ggggattcta taaaaaagca acaaatgtca tgttaaattg ataattttgt gacaacttta 1211041 ttaaagattc attttagata tatcttttat tcgtaagatc atgtatttta aagatatatt 1211101 ttaaatacat cttttcgaaa ggattgttta taaaatgtta gataacaaaa caatcgaaat 1211161 tattaaaagc actgtacccg tattgcaaca gcatggagaa acaatcactg gccgttttta 1211221 cgatcggatg tttcaagacc atccagagct tttgaacatt tttaatcaaa caaaccaaaa 1211281 gaaaaaaaca cagcgaactg cactggcaaa tgccgttatt gcagctgcgg caaacattga 1211341 ccaattagga aacatcattc cggttgtcaa acaaatcggc cacaagcacc gcagtatcgg 1211401 aattaagcct gagcactacc caatcgtcgg taaatatttg ctgattgcga ttaaagatgt 1211461 attgggagac gctgcaactc ctgacattat gcaggcatgg gaaaaagcgt acggagtcat 1211521 tgctgacgcg ttcatcggaa ttgaaaaaga catgtatgaa caggctgaag agcaagccgg 1211581 cggctggaag gagtataagc cattcgttat cgcaaaaaaa gagcgggaaa gcaaagaaat 1211641 tacatccttc tatttgaaac cggaagacag caagccgtta cctgaattcc aagcagggca 1211701 atatatcagc atcaaagtgc ggattcctga ttctgaatat acgcatatcc gccagtacag 1211761 cctgtctgat atgccgggaa aagactatta tcgaatttca gtgaagaaag atggtgtcgt 1211821 gtcttcctac ttacacgatg ggctgcagga gggagattca atagagatca gcgcaccggc 1211881 aggggacttt gttttagatc atgcatcaca aaaagatctc gttttgatca gtgccggagt 1211941 tggcattaca ccaatgatca gcatgctgaa aacatctgtt tccaaacagc ctgaacggca 1212001 aattctgttc attcatgcgg cgaaaaacag tgaatatcat gcattgcgcc atgaagtaga 1212061 agaagcagca aaacattctg ctgttaaaac agcatttgtg tatcgcgagc cgacagagga 1212121 agaccgtgca ggtgatctgc attttcatga aggacagatt gatcagcaat tcctcaaaga 1212181 actgattgcc aacacagatg cggattacta tatttgcggt tcaccgtcgt ttattacggc 1212241 aatgcataag cttgtatcag agctcggatc agcgccggag tctatccatt acgagctatt 1212301 cggcccgcaa ttaagtttgg cgcagtccgt ttgaacacat acatgaaact cttctccttt 1212361 cagagaagag ttttttattg agatataaga aggcagacaa gcgccggttt ctacatccgg 1212421 acaatcacag acccgctgcc atttgtgcat acacggtttt gctgttcttg cattgttctc 1212481 agcaattcat tgtttacctc aatcgctcta attagttgct tcattcttag ctccaaaccg 1212541 gccagcctgt cgattgtttg ctgctggtag ccctcgggtt ggggagccaa tggcagatca 1212601 aagggccaaa gggtattcga cttctgattt ttcatattgc gtattgcgcc tccaatcggt 1212661 gtcactttct attatgttat gttcaggcga tatgcacgtt cgcctagaca ctgatgcata 1212721 gagggcctgc cacggggcac aataggctca atatgaccag cggatggagg taaagatcgg 1212781 tgttatggat ggtatgggta tttttactga agccagttat cgtattttcg attgcatata 1212841 ttttgtttcg gcttgccggt aaaaaagctg tgtcacaaat gaacaatttt gacctgcttt 1212901 tgaccttcgc aatcggaacc attatcagtg agccgatcct tacatccaag ctgccgatgt 1212961 caatttatta tgcgggtgct tttttggtgc tttatcttat catgagcaag ctctctttat 1213021 ctaataaatg gcgatggctc ctagtcgtga gcccgactgt cctaatccga aacggggata 1213081 ttgatgaacg cggccttcgt aaagaaaggc tgactgttaa tgagctgctc ggaaagctga 1213141 gggaaaaggg ctatgccgac ccggctgaca ttgatcttgc tatcattgaa gaaacgggag 1213201 aagtaagcgt catcccgaaa gaggaagcga gagcggtgca ggtgcgggat ttgaatatgg 1213261 aagctgaacg gaattttatc ccgattccgc tcatactgga tggcgaaatc cttgatcata 1213321 atttgaaata tctccaaaaa aaccgatcct ggctgtttga gaagcttgag gaaaaagggt 1213381 acagccccaa actgctgtct tcgattatcc ttggcacgat gaatgcacgc ggtgatatat 1213441 cccttgattt aaataccgct aatgaaccgc agcatgatcc ttacttatat aaaccgggaa 1213501 ataacaatta agatggctct ctcttgtaat gagagctttt ttctttttta aagggaattt 1213561 ttgtttggtg tcaaatgtac ctagttagga ggggaactga acatgaagga cttatccata 1213621 agaaacgaca tggcgccaac ggtcagtttg ctgtattccg cagtggaaga aaacagtctc 1213681 cgtctggctt ccatcgtaag ccatatgaca cacagtgaac tttactataa ggggcgctgc 1213741 caaacaaaaa acagcacggc tcagcttttg caccatatca caaatgttga tatcagatgg 1213801 gtctggcgta tcaaggaaaa tcggatcccg gaccatattg aacaggcata cggcccgatg 1213861 acagatgaaa gcggacggct gcctgaaccg gtgaatcagc cagacttaga tgaactcctg 1213921 aaaagacatc agcatgtagt agagaagctg aaatcggtat gcttcacttt aactgaaaat 1213981 gctttgaacc agccgctttc cttcgaaggt gacaccgcga cgatacgatg gggaatttgg 1214041 catatggcag atcataaccg ctatcatcag gcacatattg aagctctcaa aaaagaatgg 1214101 aagcaggatg tggcgaagta tgaacgctaa aacgaagctt gtgactgatc gaattcgttt 1214161 gcgctgtatg gaagatcggg atcaagccac tttgtttggg ctgcttttta atgatcctga 1214221 cgtcatgaca tattattccg gtttaaaaga taagaggcaa acccgcgagt gggtcaattg 1214281 gaaccaacga aatgaaaaag ggtacggcgt tagtctgtgg atcgccgaag ataagcggac 1214341 aggggagttt ttggggcaat gcggcatcgt tccccagcag atcgaaaatc aaaccgtaat 1214401 ggaaattggc tatatgtttg cccgccgcca ctgggggaac ggctatgcgc aagaagcggc 1214461 tcgggcctgt ctggactatg gctttaacga gcggcagttc ggcaaaatgg cggctttgat 1214521 tgatccgggt aacaaagcgt ccatacgggt agcggagaaa atcggcatgc attacagcaa 1214581 aacgatcaga aaatggaata aaccgatcgc ggtatatgaa agaaaatctt acaattgaaa 1214641 gatagagctg agtttagtat catgatatca tgtaaagttt tctagggttc cgcatgtcaa 1214701 ttgacatgga ctggtccgag agaaaacaca tacgcgtaaa tagaagcgcg tatgcacacg 1214761 gagggaaaaa agcccgggag agtcaatctc atgtgagacg actgtccggg gtttttttgt 1214821 tttcggagaa tcttaataga tagaaaggaa tgactcaaaa tgaaatgggg attggtcgtg 1214881 cttgccgctg ttttcgaggt tgtttgggtg ataggcttaa agcacgctga ctcagcctta 1214941 acatggagcg gcactgccat cggcatcata ttcagctttt accttctaat gaaggcgact 1215001 cacagtctgc ctgttggtac cgtgtatgcc gtctttaccg ggctcggcac agcgggaaca 1215061 gtacttagtg aaatcgttct ttttcatgaa ccggttggat ggccgaagct attgttaatt 1215121 ggcgtgctct taatcggtgt aatcgggttg aagcttgtga cacaggatga gacagaggaa 1215181 aaaggaggcg aggcataatg ctgcactgga tcagtttatt gtgcgcgggc tgtttagaaa 1215241 tggccggcgt ggcccttatg aatcaatatg cgaaagaaaa aagcgtgaaa tgggtgctgt 1215301 tgatcattgt tggttttgcc gcttcatttt ccttgctgtc gtacgcaatg gaaaccactc 1215361 cgatgggaac ggcttacgcg gtctggacag gaattggcac cgccggcggg gcgcttatcg 1215421 gcatcctctt ttacaaggag cagaaagacg ccaaacggat cttctttatc gcgttgattt 1215481 tatgctcagc agttggttta aaaattctgt cataaattga tttttatcaa atcttcagta 1215541 taatggataa atagtttaga cttacaaaga taagagggat tattcatgaa atcatatatg 1215601 actcagcggt tggacgaata ccgtgacgga aatgaggata aaggtcggct cttggtcagc 1215661 tgccccgatc agccgggtat cgtctctgca gtttccgcgt ttttatttga acacggtgcc 1215721 aatattatag aatcaaatca atatacgaca gaccctgaag gcggccggtt cttcctgaga 1215781 atcgaattcg actgcgcagg cattcgtgaa aaaaaatcat cacttcaggc agcgtttgcc 1215841 tctgttgcgg aaaaattcga catgacatgg agcttaactt tggcgagcga actgaagcgt 1215901 gtcgccattt tcgtttcaaa ggagctccac tgcctgcatg agctgatttg ggaatggcaa 1215961 accggcaacc tgatggcgga gatcgctgtt gtcatcagta accatgagga agcgagagag 1216021 ctggttgagc gcctgaacat tccattccac tatatgaaag cgaacaaaga catcagagcg 1216081 gaagtcgaaa agaagcagct tgaactgctg gagcagtacg atgttgatgt gatcgtgctc 1216141 gcacgctata tgcagattct aactcctgat tttgtttcgg ctcatccgaa tcgcatcatc 1216201 aatatccacc attcattcct gccagctttt atcggtgcga atccgtacaa acgggcctac 1216261 gagcgcggcg tgaaactgat cggtgcgaca tctcattatg tgacaaacga tcttgatgaa 1216321 gggccgatca ttgaacagga tattgagcgt gtggaccacc gcgataatgc ggaagcgctg 1216381 aaaaacatcg gaagaacaat tgagcgcagc gtgcttgccc gtgctgtgaa atggcatttg 1216441 gaagaccgtg tcatcgttca tgaaaataaa acaatcgtct ttaactagac tgcaagaggc 1216501 ccgcgcaatg cgggctattt ttgatgacaa aaaaccttga caagtgtctt ttttctttgc 1216561 ataatataaa aaaatcattg agcgttgaag aggattagta agcagacctt tctgtgacag 1216621 agagcaaaat gaatcgctga aacattttgc cgcatgaaac ctgccgaacc tgccttggag 1216681 tcctaggggg aaaacctagg cgcataacct ggcgttacag gagagcggag cgtgcacaag 1216741 cgcgttcaat caaggtggta ccacggaaac ccatttcgtc cttatgaatc aggatgaaat 1216801 gggttttttt attgtagaag agccgcggag gagaataaat gaaaaaacaa agaatagtag 1216861 tgaaaatagg aagcagttcg ctcacgaata gcaaaggaag cattgatgag gcaaaaatca 1216921 gagagcatgt tcaggcgatt tccgtgttaa aaaaagcggg gcatgaaatg attctgatta 1216981 cctcgggtgc cgtagcggcg gggttttcca gcctcggtta tccatcccgt cccgttacca 1217041 tcaaaggaaa acaggcggcg gccgcggtcg gacaaacact gttaatgcag caatatatga 1217101 atcaatttaa acaatactca ctgactccgg gacaaatcct tttaacgaga aatgattttt 1217161 cgaaaagaga acggtatcga aacgcgtatg ctacgataat ggaattatta gagcggggcg 1217221 tcattccgat tatcaacgag aacgattcta catctgttga agaattgaca ttcggagata 1217281 atgatatgct ttctgcgtta gtcagcggat tgattcacgc ggaccagctc atgattctca 1217341 ctgacattaa cggactgtat gatgccaatc caaatgaaaa tcctgaggcg aaacgatttg 1217401 attatttgcc agagatcacg cctgaattgc ttggatatgc aggttcagct ggatcaaagg 1217461 tcggcaccgg cggaatgaaa tcaaagctgt tagccacaca aaccgcgctg tctctgggag 1217521 tgaaagtatt cattggaact ggcagcggag agcaaaaact tgcggacatt ttggacggca 1217581 ggggagacgg cacttatatc ggagacaaag aactatcttc ggttaacaac acaaggcagt 1217641 ggattcagtt ccactcgccg atatcgggag aaattatcat tgatgcgggt gccgaagagg 1217701 cgatgatcca taatggaagc agccttttgc ccgctggagt tgtgggcgtg aacggaagct 1217761 ttccgaaagg ggcggttgtg gaagtcaggg gaccgggcgg cgtgatcggc aaaggccaaa 1217821 ctcattactc ctccgaggag attatggagg ctaaaggcaa acgcagtgac gaacttgatt 1217881 ttgagaaaac gtttgaggtt attcatagga atgactgggt caatgtaaaa gactaggagg 1217941 cggaaaaatg agtgaagttt ctgtaaaagc gaagctggcg aaagaagcag cagccgaaat 1218001 gatcatgaaa acaacagccg agaaggatga ggcgctcagc ctcattgcaa acggactccg 1218061 caaagaactg gattttctct tggcggagaa tgcaaaagac attgtgaacg gaaaagagaa 1218121 tggtttaaca ccggacatca ttgaccgtct ctcattggat gagaaacgga tacgcgatat 1218181 cgcggacgcg gtggagctct taatcgactt agcggaccca atcggcgact ctcttgaaac 1218241 gattgaaaaa gaaaacggcc tgtttattga aaaaatccgt gtgccgctcg gtgtcgtagg 1218301 aatgatttat gaggcgaggc caaacgtcac agttgatgcg gctacccttt gcctgaagac 1218361 agggaacgcg gttgtgctgc ggggaagctc ctcagccatc cacagcaaca aagcgctcgt 1218421 cagtgtcatt tacagagcac ttgagcaatc agcgcttccg attcacgctg tgcagctgat 1218481 tgaggatacg agcagagaga cagcaaaaga gctctttacg ttaaatgatg gcttagacgt 1218541 attgattccg cgcggaggca agaaactgat tgatctcgtt gtgagagaat caacagttcc 1218601 tgtattagaa acgggagcag gaaactgcca catattcatt gacgaaacag ccaaaccgca 1218661 aatggcagaa aaggttgttg taaatgccaa aacgcagcgc ccttctgtat gcaacgcgat 1218721 tgaatcattg ctgattcaca aggcttgggc aagacagcac ggaaaagaat tgctggacca 1218781 gctggaaaac gcgggagttg aaattcgcgg tgatgaattg gtatgtgaac ttcatccttc 1218841 aagcaaacaa gcatcaaaag aagattggga aaccgaattt ttagcgcctg tcctcagcgt 1218901 aaagacggtt gaaaacgtcc aagaagctgt aaagcatatc caacaatacg gcaccaatca 1218961 ttctgaagcg attttaactg aaaatgacaa aaatgcggta tattttcaaa cggctgtcga 1219021 tgctgccgct gtctatcata acgcgtcaac ccgctttacc gacggctttg aattcggcta 1219081 cggagccgaa atcggcatca gcacgcaaaa gcttcatgca agaggaccga tggggcttcc 1219141 tgcactgact tctacaaaat acatcattaa aggaactggg caaatccgtg aatagcgggg 1219201 taatgttcaa tgaaaaagct tatctcatta cgagataagc ttttttatac gcgaaaaatt 1219261 gacatttcaa atttaattgt gtacaattta attgtataaa atatattggg ggaatgaaaa 1219321 atgagtcagc cattatttac cgcaactgtt tcagcggtag gaggaagaga aggaaaggtc 1219381 atttcatcag accgcgttct tgagcttgat gtcgcaatgc cggggacacc gagagccaag 1219441 aaattagaaa aagcgacaaa tccagagcag ctgtttgcag caggttatgc agcttgcttt 1219501 gacagcgccc tgcagcttgt cgcaagaaca gaacgggtaa aagtagagac agaggttaca 1219561 gcaaatgtta gcctgttaaa ggatgaagcg gaccagggct ataagctggg tgtgacgctg 1219621 caagtaaaag gagaaggagt cagtgcatca gaattggagg cgcttgtgaa aaaagcgcac 1219681 ggcgtctgcc cgtactcaaa agcaacctcc ggaaatattg atgtgacact tgaagttgct 1219741 gaataaataa aaagaggatg cctgtacaag gcatcctcaa tttttttgat gaagtgtttc 1219801 cagtaatgta tatagagcgg actttaactg tttgagatcc tccccagact gctttgagag 1219861 ccccagaatt gtccctggaa tgtcaaccgc tttttctttt aataacgctc cgtcctctgt 1219921 caggctgatc aacacggacc gctcatcctc ttcagatctt tttctcgtaa tcaaaccctg 1219981 ttgttccatt cgtttaagca tcggagtgag cgttcctgaa tctaaataca gctgttcgcc 1220041 catttttttg acagtaagcg tttcatgttc ccataacaaa agcaaagcca aatattgagg 1220101 gtatgttata ttcagcttat caagcagcgg cttgtattgc tttgtcatct cccgcgaact 1220161 cgcatatagc aaaaaacaaa gctgattctc caatttcata tgatcaaatt tattttccat 1220221 tttgttcacc aactcttttt tgtcattcga ttctattgta tctgaaaaac ctcacttttc 1220281 ctattctcgg caaacatagc atgtttaaaa agatcagaaa gggaaatata acaactagat 1220341 acaaataagg aggttgggaa atatggcact atttacagca aaagtaaccg cgcgaggcgg 1220401 acgagcagga catattacat cagatgacgg tgttcttgat tttgatattg tcatgccaaa 1220461 tgccaaaaaa gaaggacaaa ccggcacaaa tccggaacag ctctttgcgg cagggtatgc 1220521 tgcatgcttc ggcggcgcgc tcgaacacgt agccaaagag cagaatatcg aaattgattc 1220581 ggagattgaa gggcaggtca gcctcatgaa ggatgagagc gacggcgggt ttaaaatcgg 1220641 tgtcacactt gttgtgaaca cgaaagattt agatcgggaa aaggcacaag agcttgtcaa 1220701 cgccgctcat gaattctgtc cttactcaaa ggcaaccaga ggaaatgttg atgtaaaact 1220761 agaattaaaa taatgaccgg catcctgagg attctcagga tgttttttgg tgtcggacat 1220821 gcggggcggg cacagattta tgataaaact tcagagaagc gtttgaagca tgcctttaaa 1220881 ccaaaagtta cagatgaagc gggtggctgg cacggtgtct gccgtgctga attgcgcgta 1220941 tatgctgttt tgtatttgca cagggcatag cggctacttg gagaaataac aaggaccagg 1221001 ccgcgcatgc ctgatccttt taatattctt tcttattggc gaagttccgc catgcttgaa 1221061 acggggataa atgctctgtt agtgtcactt gataaaaggg gatcgttctt tcttcagcag 1221121 gtttatcaat ttctttataa atgaatgaat catcaaaccc ggcttcggca gcgtctgtgt 1221181 gctcagctgc atagaaaacg gctttaggcc gggcccagta gatggcgccc aagcacattg 1221241 ggcatggttc acagctcgta tacaaaatgc agtcatcaag ctggtaggct cctagcacct 1221301 tacaggcttt ccgaatagct gtgacttccg cgtgggcagt cggatcattg cttgttgtga 1221361 cgttgttctg tccctctgca ataatggctc cgtctttcac gataacggct ccaaaaggcc 1221421 cgccgattcc tgcattcact ccttcacatg cgagagtgac agcccgtttt aagaacgttt 1221481 catgattcat cccaatccct cctgtcaata gagtgttatt agtatagccg aaaagaatgc 1221541 aaagaacatt cttaaaaaag tgcaaaataa acaaagtatt tgggggattt gctaaataag 1221601 aaaccgattg tggctgtatt atagaaaaaa accatctgcc aaatgcagat ggttttttca 1221661 aattatacta gctgtgtctg ctgtgctctt gcctgttttg cggcttcaac catatttttc 1221721 aatgctgcaa ccgtttcttc ctgctgtctt gttttcaatc cgcagtctgg atttacccag 1221781 aagcggtcag tcggacagac ggcaagcgca tcaacgataa tattgtacat ttcttcagtt 1221841 gacggcacac gagggctgtg aatgtcatat acaccaaggc caagcccttt caaatacggg 1221901 tggtttttta agtaatctaa aaatcctccg tggcttctgc tatgttcgat tgtaatcaca 1221961 tcggcatcaa gatcattgat tgtatcaacg atatcttcga agttgctgta gcacatatgt 1222021 gtatgaattt gtgtctcgtt tttcacggaa gaagtggtta atctgaaagc ttctgccgcc 1222081 caagtcaaat actcatccca atcgcgggtt ttcaatggaa ggccttcacg cagcgctggt 1222141 tcatcgactt gaatgatttg aatgcctgcg tcttcaagcg ctttaacttc tttgcgaagg 1222201 gcaagcccga tttggaaggc gatttctttc ctcgagatgt cgtttcgagg gaaagaccag 1222261 tttaagattg taaccgggcc cgtcagcatt cctttcacat gcttggaagt caatgactgt 1222321 gcgtagactg tgtctttcac tgtcatcggt tcaataaatt caacatctcc gtaaatgact 1222381 ggcgggcgga cacagcgtga gccgtatgat tgaacccagg catatttagt gaaggcgaaa 1222441 ccggccagct tttcaccgaa gtattcgacc atgtctgtcc gttcaaattc gccgtgaaca 1222501 aggacatcaa gctccaattc ttcctgaata tcaatccatc tttttgtttc cgcattgata 1222561 aagttttgat actgttcatc ggaccactca gctttccgcc atttttggcg tgcgctccgc 1222621 acttcagcag actgcgggaa gctgccgatc gttgtcgtcg gcaaaagcgg aaggccgaga 1222681 gattcatttt gtagggctaa acgttcttca aacggaatcg ggcgcttgaa gtctttatca 1222741 gttaattgct caagctcttt cttttgttca gaattggcgc ctgttgcaaa ctgtttaagc 1222801 gcctggatat cagccttagc ctgctgaatc tcttcgctga tcgccgcttt tcctgatact 1222861 aagccttctt tcaaagctgt cagctcggcc agcttttctt ttgcgtagga taatccgttc 1222921 aataggtctt tttccaaatg ctcatcaggg tgtttcgcta ctggaacatg cagcaggctg 1222981 ctggaaggct gaatccacag ttcatcaact tttgcaatgc tgagaatatc aagaacggca 1223041 tcgagacgct cttcaaggtc cgctttccaa atgttgcgtc cgtcgataac gccggctgcc 1223101 agcactttat ctgtcgggaa gccatgtgtt ttaagctgtt ccaggtttct gcctttgtcg 1223161 tgaacgaaat caaggccaat tccctgaacc gggtaagaga tcagctcttc ataagcatca 1223221 acagaatcaa aatacgtctg caaaagcaca ttcaaggatg aaagctcact tgtaatgctt 1223281 tcaaataatt cttttgcgcc gcgtacatct tcactagagg cggtaacgag cgccggctca 1223341 tcgatttgaa cccattttac gccttcttct tcaagctctt tcaaaagctg tacatataat 1223401 ggcacaaggc gtttttggat cgcttttgct tcagacggtt catagccttt agcaagcgta 1223461 acgaacgtat aagggccgac aatcacaggc tttgtttcca caccgtattc ctgtttgatc 1223521 cggcgataat cttcgagttg tttgtttctt gtcagacgga actcaatgct ctcgtcatat 1223581 tccggaacga tgtaatggta atttgtatta aaccattttg tcatttcact agatacagcg 1223641 tctttgattc cgcgggcgat agcgaagtat gtatcggtag cgtcagtcaa atgtctgaac 1223701 cgtttcggga tccagttgaa gctgactgct gtgtcgagta catggtcata ctgtgtgaaa 1223761 tcagaaacag gcacaacatc aatctgctgg tcaatttgtg tttttactgc ggataaaaat 1223821 agttcgtcga tttgcttcaa aaacgtatct ttatcagtac tgcctttcca atacgcttca 1223881 agtgcttttt tccattcccg gttcagtccg attctcggaa atcctaaatt cgatgttttg 1223941 atggttgtca ttgtttctcc tcctttatat gtaaaacact ctctttcacc cgcggataca 1224001 ggctgctaag aggttttctc acaacaaaaa gcctctttcc catgagagaa agaggctttt 1224061 ctacgtaaaa cactgcctct ctcatctctc agacacaatc tgatggaatt agcaccgtgc 1224121 cttatgagac atcagtctcg gcgcgaaaag cagtgcgccc catttcacaa tggtattacg 1224181 gtcggttgct gttggggtca aaaggccaat ccctcgccca actctcgata agagaaaatg 1224241 ttattaattt tttgaaaagt tgaatcattt gttggtaatc ttaacagtaa ttcaaattca 1224301 ttgtcaacat agaatttgaa atttttattt acatgatgtg gtgtatatta tataagaaaa 1224361 ataatcttat agggtcaaca aatgtgattg ctctgctttt tctgcgagct catcaggagc 1224421 tgttaaatac aggaatccat tgcctgccag cgtttttgca atatcaagag gaagtgtcct 1224481 gcggattagc tgtgcgaaaa cctcagattc agaaagcttt ctttgaaatg attcttcttc 1224541 atagcttttg attaaagcaa gcgcaccgct gacatgaggg gcagccattg aagtgccggt 1224601 cagcttaccg tacttcttgt tgggaagggt ggataagatg ttttctcctg gtgccacaag 1224661 gtcaatctct ttattcgcgt tagaaaattc tgataattct cgcgctacag aaacagatcc 1224721 aactgcaatc acttcattat aagctgcggg gtaggaaagc tcttctgtgc gttcgtcgcc 1224781 gtcaccttca tttcccgctg cacaaacgac aagcactccg tttttcactg cgtttttcac 1224841 tgcttctttt agctctggca catcgcttgg ccctccaagg gacattgaga tgatgtcgac 1224901 tttctgttcc accgcgtagt tgatgccgtt aattatccat tcgtattgtc cgctgccgtt 1224961 ctcgccgcca agaaccttca caatcaatag gcttgcctca ggcgcgactc cggcaatgcc 1225021 tccgtttgaa tcattagctg caattgttcc ggcgacgtgt gtgccgtgtc cgttgtagtc 1225081 ggaaatcgca tcttccttgc cgccgtcgtc atccgtgaag ttctttccgc cgatgatttg 1225141 attttttaaa tcagggtggc ttgtgtcgca gcctgtgtct aatacagcaa ctttaatatt 1225201 tttgcctttt accccttttg cccacatttc tggcgcctta atcactttaa tgccctcagg 1225261 aagctcgttt acatccatga tctgctcatt cgtcacatac gggatcaagc ggatttcacc 1225321 attcataaaa aagccctcct tttttatgct tgcaagtgga ttcaagggtg ttgcctcata 1225381 ttatatgaaa aaagcaagcg ctcggacaga gccatttgaa gcattttgaa aaaataggat 1225441 acacaccaaa gaattagtaa tcttcaaaat attggatggc ttcaacatgt atgactggga 1225501 ttcaactgta agtcaagtta taatagtgtt ggggaaagga gcagtgtcat gaaactgaat 1225561 gaaaaattat atgcattttt ttcagagcat gtggaacaaa tggccgagga atggattgaa 1225621 acgatggagg aaagtgatcc gaattcgctt tacgccctac ataatgcaac agtaacggaa 1225681 gaattgaaag agcaggacag agaattttac cggcatctga attacatgta tgttttaccg 1225741 gaaaaacaat ttctcgaaga gtttcaagag tgggtcattg agctgaccaa cgatcaaaaa 1225801 catctcgaca caccggttca gtatgtcatt cgggagttta tgagaaacag gagattatat 1225861 acgaagtatt ttgagaagtt cgcagaagaa aatgaatcag cgtttgaacc gggagagaag 1225921 caaaaatggg cagatttgat tgtaaaagta tttgatttca ccatttatac attcgttgat 1225981 cacgctgaaa tgaatgccaa gcagcaatta aacgcccaaa gagaaatgat attggaatta 1226041 agctcacctg tcattaccct gagcaaatca acagctctgc tgccgcttgt cggtgacatt 1226101 gataccgaac gggcgaagtt tattctggaa aacacgcttc aagcttgtgc gaaaagacgt 1226161 gtggagcatc tgttaatcga tctgtcaggt gttgttgtgg tggatacgat ggtggcgcac 1226221 cagatcttta aattgattga ggcgcttaat ctgatcggtg tccggtcaac cctgtcagga 1226281 atcaggcctg aaattgcgca aactgctgta cagctgggga ttgacttttc gaatattact 1226341 attaaaacca accttgccca agcattaaac tatcatcaat aaaaaaatcc gctatctgtg 1226401 atagcggatt ttttatgatg cgaaacataa agatacgaga aaggatcccg cgaataataa 1226461 gaggacgagg caaaagaaca cccagtcgcg ccggttcacg ctcaatgtcc tgtagtatgt 1226521 ccggtttctg cttcctgtaa atcctttcga ttccatcgca agcgctgtcc gttccgcttt 1226581 tctgatggcg cttgccaata gcggtatggt atatcgtttt aacgcactga ttttattaat 1226641 gatgccgctc tccgccgctc ctcctctgat tttatgagcc tgctgaatca gctggacctc 1226701 atcctttaac agcggaagaa agcgaaagcc tgcaatgaca ccgtacgcga gctttggtga 1226761 gagcctgcac tgctggacaa ggctcagcat aaatagaatc ggatcggttg taaaaacaaa 1226821 catcatcgat aaggcggaaa agcataaaat acgaaacccg agagagatgc cgacagacac 1226881 attatcgctg ttaatggaga tagggcctgc ttgaaacaaa aaattatccg gtgttgtcgg 1226941 cacttttcca aaaactgcgg ctgtccacac gcatccgaat gctaaaatca aaaacggaat 1227001 cgtaaacaac aaccattttt tcaatgggat tccggccgcc agtaaaacgc ccgcaacgat 1227061 gatgatataa aaacatgccg gagtgtaagg gttgtaaata aacgacagca tgacgacaca 1227121 acaaaaaacc gccgccgctt tcacagtcgg attaatgaga tgtaacggtt gcttcatcac 1227181 gcacctcctc ttgaaatgcc atccattcat atagaagggg aagggtgagc tttgcttttt 1227241 gaacaagccc tgtttcttga gaaaacaact gcgctggaga tccgtcaaag gccaggcctg 1227301 tatcgtgaag cacaagcacg ctgtcagcat acgaagagac tagctccata tcgtgtgtaa 1227361 tcataaggac agcagttccc tctgccttga tacgttgaat catttccatg cattcagccg 1227421 ccgtgcgggc atcctggcca aaggttggtt cgtctaataa taaaaccttt acgtcatgca 1227481 tgagcatagt agctacgctc agtcgccgtt tttgcccttg gctgatcgca aacggatgat 1227541 gatcagccaa atgcgcaaga ccaaaacgct gcagcaggtg ttgcgctttt ttctcagttt 1227601 cagcatttgc tttctggccg aacagaagct cgtcatacac cgtatcggtg acgaattgat 1227661 gctcagggtt ttgaaaaaca aatcccatcc gtttacgcaa ttctttttct ttatatttct 1227721 gcagcggctg atcatagaga aggattttgc cgctttgcgg tttcatgaga ctggccagaa 1227781 ctgataggag cgtcgatttt ccagttccgt tcggaccgac aagcgccgtt aaagagcctt 1227841 cgcgcaacga aaagctgatg tctttgaaaa tcgcctgctg tcctctcgcg aacgaaaggc 1227901 tgctgacttc aagcacactc tccccagaag gggctttctt ctttttgaca tgcccggcag 1227961 gaataggctc tttgaacagc atctcttttg ataaagtaaa cggcatactc agcttttcct 1228021 gcagatgaca gacctttgga atggcgatgc ccaatttctt tagtgtctcc gcttcatgct 1228081 gaaatagatt tttcgtcagg ccatccagtg cctttttgcc tgatttgtcg agtacgatcg 1228141 ttctctcaat ccaaggcgcc cattcatcaa gctggtgctc aatgacgagg aggctgaaac 1228201 ctttttcccg ctgaagatcc ttcatcagat gaacgaactc ccgagctgag aaagggtcta 1228261 aaagagaggt cggctcatct aaaataataa gctcaggctc catcgccaaa atacaggcga 1228321 gagccacttt ctgcttttgt cctcctgaaa gggttgagat cattttttct tttaaatggg 1228381 taatgcgtaa tttttctaat acggcgttga ttttctctgt catttcttct tttggaattt 1228441 gcagattttc cagcccgaac gctatttcgt cctccaccgt cagcatgcag aactgctgat 1228501 caggatcctg aaaaacgacc ccggcatgct gagtaatcgt ttcggaggtt tcagcatctg 1228561 tgaccggctt ttgaaataga aatacatgtc cggactgaat gccgtcgcaa gcctccggat 1228621 atagaccgtt taaacaaagg gcgagcgagc ttttaccgca tccgctcggt cctaataata 1228681 aaacacattc tcctttttga agctcaaacg aaatgtcttg aaaaaccggt ttctcgtctt 1228741 cttcataaga gaagctgagc tgctcaaccg tcagaagctc atcaaaggct tgcatgttct 1228801 gacgcccgct tccgtttctt tttcagttcc tttccgagtg ccattccgtt taacacacct 1228861 gtataagcga gagagtcgct gacagctttt ccgagaagcc ccgccaaaag cgcgccggaa 1228921 atgaggcgga tcacaagcat aatgagcaga taacctggtg aataggctgc atagccagaa 1228981 acaaagagat catagataaa gctggctact gaagacccca taccggccag cataaggaca 1229041 gggagagagt atgctttcca gcgtgttgca agaaatacag cctcagcccc gagcccttga 1229101 acaatgccaa tgacgatgac catcgggcca gacggatttc ccagcaggca ctcaacgaga 1229161 gcggcaatga tttcagaaac gagcgccgca cccggttttc gaatcatgta cgcggcgatc 1229221 acagaaacga taaaccaaat gccgtaaatt ggttcatagg cgattggccc aaacatacct 1229281 gcaagtacgt ttccgaaatg tgtaaataat aaataaacaa cggcaaatac gatactgata 1229341 acggacatga tgacaatttc ttttactttc cagcttttca tgttatccct gctttctgtt 1229401 ttttcttgat ggactgttag ccgaaagatt cacagtcatg gtgatgtggt ttgtttgctg 1229461 ctcagccatg cggaaaacgg cctccaatgt gctgaatacg tcatgcgcat ccccgtcaag 1229521 ctcgctcgcg taatggacac cctgtacgaa agtgccttgg gcttttgcaa tgtcgacagc 1229581 ctccataatc aatcccatat aatccggctc attcattgga taaagggcaa attggcacgg 1229641 cgcttccgcc ttcaagcctc ggacagcatc ttcattgaca cgcttatcac ctttggaaag 1229701 atatgtatcc ccctgtgtgt cacccgggca tccaatggaa aacgtgccgt tcatgacgat 1229761 gtgttgttcg ctgtttgctg catgaaggta aatggctttt gcagcatcga atacatgatc 1229821 aatcgatccg cgtaacaccg tgctgatatg gtcggttttc gtccaaacct tggatgtatc 1229881 tgtttttttc agcgcagact tgatcacact gataaaatca tccgtcatcg gatataaaga 1229941 gaagcgaaaa ccggcgattc tgcttgtacc gcaaatatgc tccatttctc cgacctcctg 1230001 tttttttggt aaaataaaaa actgcatatc ctaagggaat atgcagtcat agatcgatta 1230061 agcgcacaaa aaaatacacc attcggtcaa cctgcacttc cccacgctgg tattatccag 1230121 atcgggtcat aagggatcaa agcgcgtttc ttccgcgctt tatctcagcc aaaacagcac 1230181 ccctagtgct ttccgtatac aattttttat tttgacatca taatagatga taagaatcat 1230241 tttgtaaaca acgaaatcat ttttttcata tagggacggg agaggatggt caaatttgga 1230301 aaaaggacac atattaattg tggaagatga agaaaaaatc gccagggttc ttcagcttga 1230361 attggaatat gaaggataca gcgtcacgat caaacacaat ggcacagaag gtcttgatgc 1230421 ggcagcggaa ggcgggtatt ccttggtgct tcttgatgtc atgcttccgg ggcttagcgg 1230481 actggaagtg ctgcgccgct tgagaaaaac ggattcgcag acaccggtca tattattaac 1230541 ggcgcgagac agtattcctg ataaggtaac aggtctggac atcggtgcaa atgactatgt 1230601 caccaagccg tttgaaatcg aggaattgct tgcgagaatc agggcggcgc tgcggcaaaa 1230661 tggaacaaaa actgaagata tcggcacctt tcttacatat gacgatttgc gggtgaacga 1230721 aaaaacccgt gaagtgagac gcggagacaa agaggtggaa ttaacgccgc gggaatttga 1230781 tctgctcgtc tatatgctaa agcatccgca gcaagtgctg acacgggagc aaattctaag 1230841 ctcagtatgg ggatttgatt atatcggtga tacaaatgtc gtggacgtct acataagata 1230901 catcagaaaa aaactggact atccttacga aaaacagctg atccatacga ttcgcggggt 1230961 cggctatgcc attaaggggt aaacgatgaa gctgaagacc aagattcatc tatacacttc 1231021 gatatcactg ttgattttat taattttggt tcataccgca gtatatctca ttttttcgtc 1231081 tgcgctgaca tcaaaggatg cggcccggct tgctgatgag acggataaca ttgccgaagc 1231141 gctgcgtgcc gctgaaacag aaggagtggc tttgcaggat atgctgcagg cctatcttcc 1231201 ggcaaatggc atggtgcgtg tagtgaatgg tgatcaaaaa gccgttatga cgatcacaaa 1231261 agaaaaagcc tataaagatt ttcctctctc ttttcatagc ggcgaaacgg cagatgtgag 1231321 gaaacctgac ggcaagctgt ttgccgaggc tgctgttccg gtgatttgga ccgatggaca 1231381 agtcgtgtct cttcagctgg ttgaaagact ggagaacaca gaagagagtc tgtttctgct 1231441 gaaaatcatc ttaatcgctg caagtgctgc tgtctgcatt gcttcttttt ttgcaggcag 1231501 cttgctagcc cgccgaatca tcaatccgat cagacgatta atgatcacaa tgaaagacat 1231561 acagcgagac aaagaattta aaacgatttc tttagaagga cagtccaacg atgaattgta 1231621 tcaaatgggg ctgacattta atgaaatggc aatgatgctg aaggagcact atgataaaca 1231681 gcagcaattt gttcaagatg cttcacacga attgaaaacc ccgctcacta ttatagaaag 1231741 ctacagcagc ctgatgaagc ggtggggtgc aaaaaagccg gaggtgcttg aggagtcgat 1231801 agaagccatt cactcagaag cggtgcatat gaaaaaactg accaatcagc ttttggcgct 1231861 ggccaaaagc catcaaggac tcgaggttga tctgaaaaca atcgatctga ttaaagcggc 1231921 gcgcgcggtt atgcaaacgc tccagtccgt ttatcagcgt gacatattgc ttgaaacaga 1231981 taaagagagc ctgcttgtaa aggcagatga agaacgcatc aagcagctgt tgaccatttt 1232041 gcttgataat gcaataaagt atagtgaaaa gcctattgag atgtcagccg gaacgaggaa 1232101 tggacggcca tttctatcag tgagggatga aggcatcgga atacctgagg agcatatccc 1232161 gcatttgttc gaacggttct accgggcaga tgaggcacga aacagaaaaa caggcggaac 1232221 aggtttaggc ctttccattg ccaagcaaat cgctgatgag catggcattg agctgtctgt 1232281 caaaagcaag ccgggacaag gaacagctgt caccatgcaa ttcagcgaac agaatggggg 1232341 aggccgatga ctaaaacaat aaaaacagta tcttttgctg cagcagccat tttagttgtc 1232401 atcatctgta cgtttctcat cattcggcaa acccatgaga acgtattgtc aaaggagact 1232461 gtcgtaaaaa aagtcgaagc ctcttatgaa ggcaaggtca cgaaagcaac acaatcaaag 1232521 gataaaaaaa catatgatat aacccttgaa aatccaaagg gaacttactt tgtaaaagca 1232581 gacgcaatat cggctgacat tctttcaatg aatagagtaa aagcagtgaa tccatctgcc 1232641 atgacagaaa aagaagccga gcatctcgcg cttgagcggg tgccgggaac ggtcaaaaaa 1232701 caaacacggc aaagtcaagt tgccacttat accatacaaa aagaagacgg gaaaacatac 1232761 gaagtgaagg tagacatgca ggcaaaaaca gtcttgtctg ccgatcaaat cagcagcaaa 1232821 gatcaacaaa aaacgccgat tacgaaaaaa gaagccaaaa caattgcaga gcgaaaaacg 1232881 ggcggaacag cggatgacgc agatctcgaa gaaagtgagg gcactctcat ctttgaagta 1232941 gacgttgatc ttcctgataa taaggaagcg acagtgaaaa tcaatgccta cacaggaaag 1233001 gtagctaaca ttgtgtatga agactgacgg tttctcatca aattctcatc ttgctctcgt 1233061 tttcctttca tgttgagtat gtaaactgta ctcatacaaa acaaaggagg gctcacaaat 1233121 gctcaagaaa aaatggatgg tcggtctttt agcagggtgc ctagcggccg gaggattcag 1233181 ctacaacgcg tttgccacag aaaacaatga aaacagacag gcttcttcta agacggatgc 1233241 actcactgaa caagaagcag aagcaattgc taaaacagtt gttgacggca cagtagaaga 1233301 cattgacaga gacctttaca acggcaaaga agtctatgaa gtggagattg aaaaagaagg 1233361 tgaagactac gacgtttatg tagatattca tacaaaacaa gcgcttaatg acccgttaaa 1233421 ggagaaagca gaacaagtcg ccataaccaa agaagaagct gaagaaattg ctttaaagca 1233481 aacaggtgga accgtaacag aaagtaagct tgacgaagat gacggtgctt acatctatga 1233541 aatggaaatc caaacgaagc aaggaactga gacagaattt gaaatttccg caaaagatgg 1233601 acgcattatc aaacaggaga tagatgacta atcaaaaccc ccgctgcagc gggggttttt 1233661 catgataaga aaccttcttt tggacaatct aagtagaaaa ggaggcgaaa cgcatggaaa 1233721 agaaagagga gcaatacatc aatcaggctg aatatgtccc tcatccgacg aaggaaggag 1233781 agtatgcctt atttcttcat gaaacgtatc atttgctttc tgaagatgac gagacacaaa 1233841 caacagaata agggcttagg cccttgtttt gttccgtaat tgtgatgtaa gcgcatttat 1233901 tacttttttg agttgacata gcttgttttt ttctgtaatc tcagtgtgtc aattcaatta 1233961 ggaacttcgt taggtgaggc tcctgtatgg agatacgctg ctgcccaaaa atgtccaaag 1234021 acgccaatgg gtcaacagaa atcatcgaca taaggtgatt tttaatgcag ctggatgctt 1234081 gtcctatgcc atacagtgct aaagctctac gattgaaggc gcccgcacgc tttttttgcc 1234141 gtgcttcttt caccttcaat cccgaaggct ttttttatgc ctttaaaacg aaaccaatca 1234201 aaggaggtgc ggagtatgga ttctccccat tcgagtcaat ctgaagaagt acccatatac 1234261 tatgacagca agacaattga ttacacgatg aggagacgaa ctgccgcacc ttctggcgag 1234321 gccggcacgt ctccgtagag gaggtacgag tcccgatggt tcaaaacatg acctatgacg 1234381 aactcatttt acgcatcatt attttactgc gagacgggaa aatcagggat tttagaagtg 1234441 ttattgatga gcttcagccc tatgacatgg catttatttt taaagaaatg ccggaaaaac 1234501 atcgcgcccg ctatttatct tatttaactg tagacgatat cactgatatg atcggggagc 1234561 tggaacgcga atttcagctt gtcgtcttaa ataaagtcgg aaaaacaaaa gcaacactgg 1234621 cgatgaacaa aatggacaac gatgacctcg ctcaattgct tgaagaaatg gacgaagaac 1234681 tgaaggaaca gcttttatcc agcatggaag cgtcagaatc aaaagctgta cagctcttga 1234741 tgaattaccc ggctgattca gcgggacgca tgatgacaaa ccggtatgtg tggatccctc 1234801 agcattacac ggtaaaagac gcggtcgtca aactgaaaag cttcgctgaa atagctgaat 1234861 cgatcaacta cttatatgtt attaatgaaa gcaaacagct ggttggggtt ctttcctacc 1234921 gcgatttgat tctgggtgaa cctgaagaaa aggtgcagga tttaatgttt acccgcgtca 1234981 tatcagcaga tgctcttcag gaccaggaag aagttgcccg cctgatagaa cgttacgatt 1235041 ttttggcaat accggttgta gaagaaaaca acgtgcttgt cggcattgtg acggttgatg 1235101 atattatcga cgttgttatt cgggaagctg atgaggatta cgaaaaattt gccgcttccg 1235161 gtaaagacat cacctttgac acaaaagctt acgtggcggc ataccggcgt ctgccatggc 1235221 tgattttact cttatttatc ggactgattt caggaagcat tatcagctat tttgaagacg 1235281 cgctgaagca ggttgtcgcg cttgcgtttt tcatgccgat ggtgtcaggg atgacaggaa 1235341 atacgggaac acaatctctt gcggttgtca tcagaggttt gtctaaagaa gaaatgaaca 1235401 aaaaaacgat tgtgcgcctg atcttccggg agttcagaac aagcattttt atcggagcgg 1235461 tttgttctgt gctgattgcg attgtttcta tcatatggca ggggaatgcg cttttgggat 1235521 ttgttgtcgc ctcttcactg ttcttaacct taatcatcgg cacgatgtca ggaacgatta 1235581 tccctattat tttgcacaaa ctgaaagtag acccggcgat tgcttctgga ccgctgatta 1235641 caacgttaaa cgatatttta tctttattaa tctactttgg cattgccact gcattcattc 1235701 actcattata aacgtaaaaa gtccgtctca actgcgagcc ggacttttat tatttaacgg 1235761 tttttgtacc gaaagtgagc attaagctgc ccctccagca tttttttccg cacttgcgga 1235821 tcgtttttta acatctgttc ttttttgcgc atatccttta aaatctctgc cgtctgtacg 1235881 ccgtcttcac gcttattggc gatatccatc agccgctcca catcggcaaa ggagtatttt 1235941 cttgtccccc ttgaagaacg ctgcgggtaa atgagctttc gttcctcata atacctgatc 1236001 tgtcttacgg acaatcctgt caattcactc acaattccga ttgaaatcac ttttttgtct 1236061 ttataagaat gatcttctgt ggtcattttt ccacccctgg atgtcttttg ataatagtat 1236121 ataaaaaaca aagagaaaaa acctgacgct tgtcatattt tctaacatca aatagaagat 1236181 ttttgaaaaa atacggaaga aaaattaaca agaataatgc gtaacaccca agcgcgtttt 1236241 atcctttatg taacgaatca aacgaggagg aaggataatc atggaggaag aaaaagcagt 1236301 ctcactggca aaagaaatta tagagttgga tatcaagcgt gatgaaatgc tggagacgtt 1236361 tatgcagctt gccggagaac aggcttttca attattaaga tcggttcaaa acggacaata 1236421 ccgaaaatct tcgtaaacat aaattcttta cattagattc ataccacgtt catttaaaaa 1236481 gagtatcttt tgtataggat acctcaaaat gaaggaggac gctatgagta atttattgaa 1236541 atccgcttta gaaaaagaac gacgccatta ttctgaaaaa ctctatcaga taggggttta 1236601 taataaagag gtcatgaaca aaatgacgat ttctgagctt cggaaagaat acgcttattt 1236661 ctttcgaagc attacaaatc ataaaaatta tccttataca agataatgta taaggatttt 1236721 tttgctttta gaaggaattt ctcgaattat agcgaatacg tatagtaagg gactgaactc 1236781 ttattatatg taagggtttt cattattttt ttataaaaat cctatatacg aggtagatat 1236841 gatgagatta tcgtttaacg aagaagaagt tgagcgtgcg atgaatttgt acagagtttt 1236901 tgcaagggct ttcaaaagtg tgtccgaaca tagtatccgt gatagcaaag agcacggttt 1236961 taatcccact gaatttgctg tactggaact cctgtacaca agaggcccgc aaaaattaca 1237021 gcaaattggg tcgagacttc tgcttgtaag cggaaacgtc acatatgtta ttgacaaact 1237081 agaaagaaac gggtttttag taagggagca ggacccgaaa gataaacgct ctgtttacgc 1237141 acatttaact gacaagggaa atgagtattt ggataaaatt tatccgattc atgcactgcg 1237201 tattgcgaga gcgttttcag gtctttcgcc tgatgaacag gaccagctga tcgtcctgct 1237261 caagaaagca ggcatacaca gccagcattt gctgtttcgt taactattct acactctcta 1237321 tttcaggaga gtgttttttt gtttccatat gattcttttt aaaacatctt taatcttcct 1237381 atcagacatt tcgccaaggt atccattgac gtgtttttta tactccttca tctgttcgtt 1237441 cgattgaaaa aatgccgcga tatactcttc tgctttctgc atgtcccagt ttctcatatc 1237501 tgtgacgagt ttcctttcat gtagaaggtt taaattcatt tcctcctgtc ccggcagtgc 1237561 atgataaata aataccggaa gccgtttctg taagcattca ctgatggtca cgcctccggg 1237621 tttagtcatg atgcctgtcg cctgttcgta caaacggttc atctctgctt tgctgtgaag 1237681 gtaaggaatc gcctcaatca aggggtggtg taaacttttg acataggagt agagcttttc 1237741 gtttctgccg cataatattt tgtataagat ctttccgcct ggcgacagtt cctgcaccca 1237801 ttttaaaatc ccaccgaccc ccatactgcc ccctgtgatg atgatggtat atggcgggtg 1237861 gtgctgcaag gtatctgctg attccatttc aaaattttgg tgaactggaa tgccggtcaa 1237921 gtatatgttg ttctgatcga taccctctga tattagctgc ttctttactt ccgtgctcgg 1237981 aacaaaatgg taatcaatgt tcttccgtcc ccataattga ttcacgaaaa aatcagtgta 1238041 tacattcaca accgtcagat tcggatattc aggctttagt cggttcagca gataagaagg 1238101 cagcgcatgt gtgcagaagg cgatatcagg ctgtttttct tggaggatgt gcctcatttg 1238161 ctgtgtgaac agccattcgt acatgaaata gcgtttgtca tgctgaaatt ctccgcaggc 1238221 gaggagcctg taaatgccgc tgtacgtttt cgggaaatat tgaatccatt ttaaataagc 1238281 cacggaggac aatttttcta accgcctata cgaatgtgaa aagatatcaa tcttttcagc 1238341 tgccagccct tgagactcta attcagcctg caatgcatca gccacatgat gatggccggt 1238401 ggaaatgctt aaaaaaggaa aaatgagaat gtttttcatg acagtcctcc taaaaaaata 1238461 tggcaactat attttgagga gaacgttcac aaaatataag ggtgtttttg atcataagga 1238521 aggtgaaaag atgaaaactt gtttcctttc catatggaga gtggttgatc cgatttattt 1238581 ctttttttca aggctaagct tgattgacaa cgatcaaaaa agcgtttttc gagtcaggct 1238641 gacgaagtac aaaggacatc atgtcgtgct tagcgacgga acgcatataa gaaaaaatga 1238701 tgtgctcgtt aaaatccacc tgcataacat aaagctgatc agggagctgc aaagcattga 1238761 gagcgcagtc agaaagggaa tcattattta tcagaaagta tatcaatcga tgccgcttct 1238821 tcttgactat atcaacaatc ataaaaaaag cgagaaaatc aaaggaatca ttgggattac 1238881 aatgcttgac aaaggtgtgg aaaggctcgg ctttgatgtg atcaccccgg tgaacccttt 1238941 ttacagatgc tttaaaaaag tgtctcatgt gccgatttta tatttgactt caaagcctgt 1239001 gagcttgcgg catttaccga attcatccta tttgtttatc tcaaaagaaa agctgcagaa 1239061 aacctatcaa aaaaaagact gatgcctcgg tcagcacagt cttttttgat taaatctgat 1239121 gaaatgtcac ttcagggcgg cttccgacac ggatatttac gccggtttgt cccaagccct 1239181 cgctgatata aaatggttta tcgtgatgat aatgaaggcc tttaatcatg ttcattcgca 1239241 cgagctttcc cattttcacc aaatgatacg gttttggcca gtgaatttgc ccgccgtgaa 1239301 aatgccctga cagcaggtaa tcataatgaa catctttcat atccagaata atatttgggt 1239361 catgtgttaa gacaagatga tagccatttt ccagactttg ataagagccg gtgatattac 1239421 tccgattcgt actgtaatca tcaatgccga taatattgac tggtcctgca gccgtctcga 1239481 ttcgaacatg ttcattttgc agcgtgatac agccgttttc ctctaaaact cgcttcaatc 1239541 tctgaaagtc ctcttctttc aatacataat cgtggttacc gaacaccgcg tacattccat 1239601 atgcaggctt tagcttttgc aaggcgttca agtaacctgc cagtttcgga atattacgtt 1239661 tccgatcaag aaaatccccg gtaagagcaa tgatgtccac aggctgatct tttgttaaat 1239721 gatacagctc ctcaggtgag actgaaatgt tttccaagtg aagatcagat aaatgaagga 1239781 tatttaattt ttttctggct ggaaggccgt ctttttggtc gattgaaatg gtgttgactt 1239841 tcacatcttt tgtattgcgg ttcgctttat atagaaatgg cacaaatacg agtatggcca 1239901 atgaaagtaa gattgtaaac aaaatatatc ccctcccttc tatcagtata gtaagtgatc 1239961 aagccctatg gatagcggga attaatgggt agagacaggt tgaaaaacgg attgtcatat 1240021 gatgaatgat ttggaaggga aaagggataa taaattttga cacatgaggc agaacatgcc 1240081 gacggagtca gaataacaaa tggatgtgta agcaatgtta cgattgatga gacaacaaaa 1240141 aaaagaaaca tattatctct ggatcgcatt atttcttctt ttattgtatg tatccccgct 1240201 ttttatttta aaggaagatg cccatatccg ggtccacgat aatttagatt ccaacatcgc 1240261 ttggtacaag gttctggccg atagcggaga aatcgtcggc aaggttgacg ctgccattcc 1240321 gcaaatcatt aacgggctgc cccgggatgc ctttggcacc gagtggagcg gaattgtttg 1240381 gctccatgct ttcttttctt ccatgaccgc ctatgcaata agccagacgg ttacaagagt 1240441 tgtcgctttt tttggaatgt atgtgctgct gaagaaacat ataatcccgg aaccaaaagc 1240501 ggctttcatc cgaattggcg tatcgcttgc atttgcctta acaccgttct ggccttcggg 1240561 aatgctgagt acgcttgggt accctttggc actgtgggct tttttaaata tccgaaaagg 1240621 ggatatctca tggagagagt ggctgacgct gggcttgctc cctctatact caagctttgt 1240681 tctaggcttc ttctttttcc tggcagggat ggcgtgtttt tggctgtatg atgccattac 1240741 aaaaagaaga tggaatttga tgttcttagg cagtattgca tttatgacga gtatctatct 1240801 tttcgttgaa tatcggcttg tctattcgat gctgtttgag cacgcaccga tgcatcgtat 1240861 cgaatttatc tcatctaggc atgacgtttg gcattctctt cgactatcca taaaaaactt 1240921 tgtctatggc cataatcatg tgatgaccgt tcataccgtt gtcatccttc cgatcctgat 1240981 ggtcgtattt gctgctctgc tgttcaaacg aaatcggaca aagccagaaa atgtttatct 1241041 gtttttatgt gtgcttaatt acgggttgtc attatggtat gcgttttggt tcaacaaaat 1241101 ttgggctgtt ccaaagcaga aatttgcttt tttagcagaa tttaattttg cccgttttca 1241161 ttttcttcgg ccgcttgtta tatacgtgag ctttgcgctt gctttatatc tcatttggcg 1241221 gatggggaaa ggatggaaat ggcttgtgta cgccgcagtc gctgcacagc tgatggtgtt 1241281 ggcgcctttt aatgaagaat atacgtatgg tgttcattac aacgcgccga cattcaggga 1241341 gttttatgca tcagagcaat tcaaagagat taaggaatat atcggacgtc cgcaagattc 1241401 gtatagggtg gcgagcatcg gactgcatcc gtctatcgcc caatataacg ggttttatac 1241461 gttagatacg tataacaatc tgtatccgct ctcatataaa tatgaattta gaaaaatcat 1241521 cgaaaaagag ctggaaaaaa attctcggct gaaacaatac tttgatgaat ggggcagccg 1241581 ctgctacctt tttgtcgatg aactcggtaa acgatatgat ttcaaaaaga actcgaagaa 1241641 aacgatcaac aaccttcaat taaatacaga tgtatttaaa aaaatgggtg gacggtacat 1241701 tttttcttca gttccgatca tgaatgctga acaaaaccat ctcgcgctcg taaagacgtt 1241761 tgaccataaa gattccgcct ggcgcattta tttatatgaa acaagataag gaggatatcg 1241821 attgaaacag tcacagccag tattaaccat cgtcgtcccg tgtttcaatg aagaggaagt 1241881 gtttcaagaa acaagccatc agctgacaga ggttgtagat gatttaattg aagaaaaatt 1241941 aattgctgaa gacagtaaaa ttctgtttgt cgatgatggc agcaaagacc gcacttgggc 1242001 tttgattgct atggagagca taagaaacaa gaaggttacc ggcttaaaat tagcctgcaa 1242061 tgtcggccac caaaaagcgc ttttagccgg attgcataaa gcgaagaata ggtcagactg 1242121 cgtcatttcg atcgatgctg atcttcagga cgacatctct gtgatccggg attttatgct 1242181 gaaatatcat gagggctgcg agatcgttta cggtgtacgc cggagcagaa aaaccgatac 1242241 ctttttcaag cgcacgaccg cgttagggtt ttatcgtctc atgaataaac ttgggattaa 1242301 attaatttat aatcatgctg attttcgttt aatgaataaa aggtcccttg aagagcttga 1242361 gcgttatccg gaagcgaatc tgtttttaag aggtattgtc cccatgatcg gctttaaatc 1242421 ggccgaagtt ttgtatgacc gcaaggaacg ctttgccggc aaaacgaaat atccgctgaa 1242481 aaagatgcta tccttcgctt ttaacgggat tacttcattc agtgtcgcac caattcgatt 1242541 ctttacgctt ttagggtttg ttttgttttt cctcagcgct gtggcaggga ttggcgcgtt 1242601 tattcaaaag ctgctcggcc atacgaatgc aggctgggcg tctcttatca tatccatttg 1242661 gtttttgggc gggctgcaat tgatgggaat tggaatcatc ggagagtata ttggaacgat 1242721 tttttctgaa gtgaaaagac ggccgaaata cgcgattgat attgatttgt ataatgaaca 1242781 gctgagcccg cttcagcgcc aggaaaaaga gcggttagaa aaaaagtaca gttaaacacg 1242841 gaaagagctg acttcattag tcagctcttt ttcttcaact gatgcaatat agcgctaagc 1242901 ggttcgtctt gcgggttgcg gtaaaaatca aaaaatgggc agccctgctt cttaattcga 1242961 tcgatgaccg tatcaattgt aaacagagcg ggtgttaaag atgattgcac ctcatgccag 1243021 tagagcgggg ctgcaacagt cccaagctca tttcctctcg ttgaataggg acagataatc 1243081 gtttttcctt ctgcatgctg caaataatca agatacaatt tgcagtgtct gtttttaatc 1243141 aagcgttcag tggtaaagag ctcgggaaat gcattggtgc agtactctgc gatcagctgc 1243201 gtaaattggc gtgtttcttc atacgtaaat gcctcgggag acaagggaat ataaagctgg 1243261 atgcctttgt tgccggacag cttcgggtac gatgtgatgc caaaggaatc caacagccgc 1243321 ttcagttcat ttgcggcctg cacggccata agaaagtcat ctcgcgaagg cgggtctaaa 1243381 tcaatgacaa tctcagccgg acgcctgctt ttaatggttt gaaaaggaac gtgaaactcc 1243441 aaagcaagct ggttgcaaag ccatagcaat gtagacatat cctcacagac aatatgttca 1243501 tggcttccat catagaaaga ctgaacaaaa tccggcgcat agtccggctt gtttttttgg 1243561 aaaaatgatt cgctcctaga tccatgcgga tagcggatga cggtgacagc ccggtttttc 1243621 agaaatggga gcaggtagtc actgacttca atcatatact gaataaaatc ttcttttgtt 1243681 tttttattct tttcaaatat gattttatcc aggcttgtga actggagctt tgggtgaacc 1243741 ggtttggagt gtcgtatgac ttgcgcatac gtgcattcgg tccagtccat ttggaattcg 1243801 aaaccgataa acgatacctc tcttaatgtg ccttggagaa ttgttaagta ttgaacagct 1243861 gcacaaatcg aaggttcaag cgtaaattcg cctgagggtg tttgatgtcc gtgctgttcc 1243921 ataatctcgc gtatagcgct tttttcctca tcacgcattc cgtgcgagac agaggcaatc 1243981 ggtgtcatta ttccgttttt taacaccgat accgtcagaa acccgttgtt agggttgaac 1244041 cctgttatgc aaacataagc ttgtttaaag tttttatatt tgagccaatc ggacgaccgc 1244101 ttcttttcaa gccatttgct gtttgttttc ttcgctacaa ttccttctcc gtcatatttt 1244161 attaccatct cccagagttg atcaaaatga tcataacagg gaatggattg aatggtttct 1244221 tttgcgtaag gatctggaga tgcaggaagc tttgctgcgg atatgagttc acgcagcgat 1244281 tttttgcggt ccaaatacga aagaagcgtt acatcttctc cgcttcgctc taacaaatca 1244341 aaggcgagaa agcagcacgg ccgcgcgttt gccgattcct gaatcttgtc tggccttttc 1244401 aaacgccccc gcacttgaag gtgttcaaaa tctgcacgac agggattcac caaacatacg 1244461 atttcaccgt caagtgtcag cggaagctct ttttctaggt gctgaaaggc agttttggcg 1244521 aattgtgtga tttcagggaa ggtgctgctg agctccacac catttctgct ggttaaggtc 1244581 acacctgaag aatggatgcg gagaatacag cggtacccat catattttac ttcgtaacgc 1244641 cattctgctc cgattggcgg tgacgaagtt aagaccggct gcatggtaaa cgccatgcgc 1244701 tatgatgtgc cggaggcttt ttttctagtt gttttttgtt ttttatctcc ggctcctttc 1244761 ggttcagcgg cttgtgcagg tgcggcagcc ggtgtctccc ggttcggcct tctggttctg 1244821 tcgatgctgg cttgcagagc gcttaccagg tcaatgacat cttcacgagg tggcgcttta 1244881 tcaggagtga cagccgtttc tttattttct agcttgtcgt tgactctttg cagcagcgcc 1244941 tgtcggtacg tgtcttcata tttctcaggc tcaaacttag cagtcagttc atctattaat 1245001 gtgatagcag tttgcagttc cttatcgttt acattcgatt gatcaggtac acctgggact 1245061 tgagcggcgc ttctgacctc atcgggataa tggatagact ccatgacgat acaattttca 1245121 taaacgcgga gaatcgccag ctgctgcttt gacctgattg tcatattggc gataccgatc 1245181 tttccggttg agcgcagcgc ctcacgcagc agggtatagg ccttcgtccc attatccccg 1245241 gggccgacaa agtaggagcg gttaaaataa atcggatcaa tttcctgaag ctgaacaaag 1245301 tcaacaatct caactgcttt ctcctcatgc tcctgtttta agctttttaa atcttcgtct 1245361 gtcagcacta catattttcc ttttacatat tcatatccct tcacaatttc atcaggacta 1245421 agagtttttt cgcaatttgt gcaaactttc tcgtatttga ttggtgcgtg atcctcttta 1245481 tggaggctgc gcagtttaat atctttatct tctgtggccg catatagctt gatggggatg 1245541 tttactaatc cgaagctgat cgatcccttc cacattgtat gcatatcgat aaaccccttt 1245601 ttttctttag tgtgaagaga aggagtacga ttcatgtgta gtaacttatg ggtgaaaaaa 1245661 agccggcgct gttattgcga cggctgttca ataatgaatt gttcgaattg ttccggaggt 1245721 attggcctgc tgaaaaagaa gccctgcaaa tggtcgcagc ctttttcaaa aagaagctgc 1245781 ttttgagctg cattttccac accttcggca atcacctgca aagacagctg atgccccatg 1245841 gcaataatag ctccggtaat ttgctctgat ttaggatggg tctgaatatc gtcaataaat 1245901 gatttgtcaa tcttcagcct gtgaatcggg aagtccttca aatagctaag agagctgtga 1245961 ccagtaccga aatcgtcaat actgattctg attcctaatt ctgttaggga tgacaaaacc 1246021 tttttggagt gattgagatt gtccattgtc atgctttccg tcacctccac ttcaagaagc 1246081 tgcggaggaa gctggtactt attaagcgta tccttgatga ggggaatcag atctttagat 1246141 tgaaactgtc tggcggaaat attaatggcg acagaaagat catagccttt gtcatgccaa 1246201 atccttgcct gcttgcatgc ttcatctata atccactttc cgatatcaat aataagtccc 1246261 gtttcttctg caacaccgat gaattctccg ggcggacgca gttgcccgtc tggtgtcaca 1246321 aggcgtatca gtgcttctgc tcctgtcatt ttttgttttt tcacactgaa ttgcggctga 1246381 taatgcaaga caaatctatc gttttcgatt gcttctctga gtaccatctc ttggttaagc 1246441 ttaacggttt ctttgttgcc gattgaaaaa gaatagtatc tgtatttgct tttgtttcgt 1246501 tctttagccg catacatcgc catatcagcc tttttcatca attcaaggcc atccgtcccg 1246561 tcttttggag atatcgcaat cccgatactg acagatgtga caagggtgtg atcttgaatt 1246621 ttgaaaggtt ttttgaattt ttggataatt tttcttgcta aaacatctgc ttcgcctgtt 1246681 cctgtattgg cgtctgttaa tataataata aattcatcac cgccaagacg ggcgataaat 1246741 ccgttatcag ggactacaga tgacaggcgt ttagctgcaa actgaagcaa ttgatcaccg 1246801 acattatgcc ctaatgcatc gttaatcact ttaaaccggt ttaagtcaag aaagaataca 1246861 acagtgttat aatgcaagga atgctcgcga ttcagcacct ttgttagatg agagatggca 1246921 tgccttctgt taggtaagtc tgtaagcgaa tcataatgag ccattctatg gatttctttt 1246981 tctgctttgt actgcttcgt catgtcttta caaatgacat aaatgctgtc tagttcctga 1247041 ttgacctcaa caggtataag cgtaatattt aagtgaaact ggcctttttc agtgataaga 1247101 tcgctatcgc tgttcatcgc ttgtttatct tttttaactt gctcaaaaag gcgcttaacc 1247161 ttcagtgatg tgtaattcct ccagtcatgc atgctgaagc caaatttgct gatcatttcc 1247221 tcaccagcgt gattggaaga tattatgtct ccttctaatg ataaaataaa aattgcatca 1247281 atattgtgga cgattaaaga ctgaaatcgc tgttcgttat cctttatgcg ttcgctctgt 1247341 ttaataaact ttcgatctgc atgggaactg aataacaata acgtttggat acaaaaaata 1247401 attaaagtaa caaaaattga ccaatgaaac gtttgcacct ccatatggct tccgggcgga 1247461 gccatgtcct tatggaaagt tgccgcaagc atccctgtgt agtgcatgcc cgaaatccca 1247521 atgcccatta caattgaact gacgccttta tagaatataa gatgctcaga atgttttttt 1247581 acggccaagt caaagaatat ttttaacgag acgaaagagg ctgcaatcgc aatgataatt 1247641 gaaactgtaa ataaaatagg ttcgtaaata atcattaccc gggaaatggc agacattccg 1247701 atatagtgca tagaagcaat agatgcgcca agcacaactg atccggtaag cagtctgtaa 1247761 tatgtaagaa tgtgccggct gacaaaatat aatgacacaa atgatcccga aacagatgcg 1247821 ccaatggctg ccattaaagg catgaattca tattccatcg gcatttccat atggacggcc 1247881 atcatcccta caaaatgcat tgaccaaata ccgaatccca taataagtga gccgccgatc 1247941 agccaaattt tactttttaa gcctgtattg atggtgactt tccttgaaag ttcaagggaa 1248001 atatacgagg cggtacaggc aattagaata gataaacata tgagagtcgt attatatgta 1248061 acgtgtattt ccaaatggag attccccccg tatcgtgtgt tccagtcttg ttgactctct 1248121 ttattatcgg ctgcttaacc gcagagtttc agccttcaaa acgatagaaa tacgagggag 1248181 atctattttt agttcaactg accgtgaaaa atgtgttaaa atcatcttga tgttttccga 1248241 aaagagaaaa atgtatgata cataaacatg aaacaaggga gttggtggct atcgaagagc 1248301 tggttatgtc atggattgaa gcatttaaaa gcttatctta ttttggaata tttctagcgc 1248361 tcagcattga gtttattccg gccgaagtcg tcttgccgct tgcgggctat tgggtatcta 1248421 aaggcgatat gacacttgct ggcgttgttt tggcaggatc gcttggagga gtggccggtc 1248481 cgcttacgct gtattggata ggccggtacg gaggaaggcc gtttcttgaa cgttttggga 1248541 agtatctctt tattaaacct gaagcgcttg ataagtcaga taattttttc aaaaaacatg 1248601 ggggctttgt cgccttcagc ggccgtttct tgcctggtat caggacattg atttccatac 1248661 cgtgcggaat tgcaaaaatg aatgtttggg tgttttcgct ttatacattc attgctatgc 1248721 ttccgattac atttgtatat gtttatctcg gtgtgaagct cggtgaaaat tggaaggcag 1248781 tcggctctat tcttgatcaa tatatgcttc cgatcgggat agcgattttg gcgctgttcc 1248841 tgctctactt actgatgaaa aagaggaaga aacgcacgca ctccgaacaa ttatctgtat 1248901 ttttgaaaaa taaacgttga caaatcactg cgctgcgcat attattgacg tataaaatca 1248961 tatttcttga aatcccaaag gggagtagcg tccggaatgt attccggaaa caaagtcgtc 1249021 atttcatgga ttgtatccat cggctttgtt ggcatgcctg aattcatgtc tagcaagacc 1249081 tttgccttat gtcggcaaag gtcttttttg catggtccgg ccggcataag atcggatgaa 1249141 gagaaagaaa acaacttttt tgggagggta tcatttatgg atgcagcatt attattagag 1249201 tatggttggg ttcttctcgt cttgatcggg ctggaaggga ttttagccgc cgataacgcg 1249261 ctggttatgg cggtaatggt aaaacatttg ccggaggaaa aaagaaaaaa agcgttattt 1249321 tatggattgg caggggcttt tgttctgcga tttggctctt tatttgcaat ttctttcttg 1249381 gtcaacgtat ggcaggttca agcgattggc gcgatctatt tgctgtatat ctcagcaagc 1249441 cacttattga aaagatatgt atttaagaaa gaagacacac ataaagagac gaagcaaagc 1249501 ggtttttggc cgactgtttt aaaagttgaa ctggcagata tcgcgtttgc tgttgattcc 1249561 atcttagcag cagtagcgct ggcggttaca cttcctggga catcactccc gaagatcggc 1249621 ggacttgacg gaggacaatt tctcgtcatt ttggccggcg gtatcatcgg actggtgatc 1249681 atgcggtttg cggcttccat gtttgtgaag ttattaaagg aacgtccaag cctagaaaca 1249741 gcagcctttg tgattgtcgg ctgggtcgga gtgaagcttg ctttatatac gcttgcccat 1249801 cgcgacatag cggttgtttc tgagcacttt atccattctg gaacatggaa gctgatattc 1249861 tggggtgtct tagcagcaat cgcggtttgc ggctggttta tgtcaggtgg gaaaaaacag 1249921 ccggagggtg cacaaaacga acaaaaaaac agcacccgtg aacgggcgta atctgaaaga 1249981 ctctgcttaa aagcagagtc tttttgtgtt tgaagcgttt tcataagcga aataaaataa 1250041 catttttata acatctttgt tacaaaaaac acgcataaaa cccccttaat tctttagaaa 1250101 ggcacgaaat catgtataga acgtcagaat ggtttgtcat aattgagaca ttggaaatca 1250161 atatttcttt ttctcctttg cgaatcccta tcaaattagc tatcattaat gagtagttat 1250221 agggaggaac tgaggtgaaa ccagtgctta gccttttgtt taaattggga aaaaagaagc 1250281 aaacacttga aaaagctgtt gagagtatac aaaaaggcaa taaagatctg caaaatgaat 1250341 taatacagca atataagcca tttatcgcaa agacggtttc atccgtttgt aaacgatata 1250401 tagatgaaaa agacgatgag ttcagtattg gactgatcgc gtttaatgaa gctatagaaa 1250461 aatattcacc tgaaaaagga aattctctgc tcgcatttgc tgagcttatt ataaaaagaa 1250521 aagtcattga ttacattaga aaagaagcca gaagcgcaca aaatataaat atcgatttac 1250581 aggaaggaga cgatcaggag tcatcacaaa gcctgattga agccgagctt tccattgatg 1250641 aataccgccg tcagattgaa caggagcaga ggcgggagga aatcctctat tttcaaaagc 1250701 agctcaagga ttatggttta tcgtttaaag aactgcttga aaattctcca aaacacacgg 1250761 atgcaaggca aaacgccata aaggtggcaa tgacgcttgt tgaacatgaa gaattggccg 1250821 ctatcctgta tacaaagaag cagcttccgg tcaaacagct tgaacagctt gtctctgtaa 1250881 gccgaaaaac gattgagaga aacagaaaat atattattgc gatgtgtatt atcattacgg 1250941 gtgattatat ttatttaaaa gattatctta aaggggtgct gcactcatga gaagagggat 1251001 tatagtagag aaaaataaaa aattcgtcac gttgctgacc cctgacggac aatttttaaa 1251061 agccaaaaat gatcgacaca gctatgaaat cggagaagaa atcatgcttc cgagtgaaac 1251121 acgcatgggc agaagggcca gcttttttga tttttttaaa ctgcgccctt tcaaaatggg 1251181 gatttttacg atgactgcta ttatgctctt tatttttata gttctccccg ttttttctaa 1251241 taataaggcc tatgcgtata tgacaatcga tatcaatcca agcgtcgaaa tggcgttaaa 1251301 cagcgattat gaagtgattg aactgacgcc tctaaacgat gagggacaga aagtcgtgaa 1251361 tgatatagat gattgggaga agactgattt taaaaaggtg attgacgata ttataaccga 1251421 ctgcagtgaa cacgggtatg taaaaaaatc gaaagaaata ttgatttcca ctgtttatga 1251481 aaacacagaa gacaatacat ataaaaaggc tgtgaaaaaa cagctgaatg atgtgactga 1251541 aaaatataaa acgacatacc gcatggaatc tctcgagtca gatatgcaaa cgagggaaaa 1251601 agcgaagaaa gaaggcgtct caacaggcag ctacatcaaa tcaaatgaaa agaatgacaa 1251661 taaagatata aaagatgact ccagcaaacc atccggggaa gaggatcaaa agagtgatga 1251721 aaatgaggat gaaaacaccg atcaaactga cacccaggac agcaagcaag gagataatga 1251781 acagctgaat gatgcggatt ccggagacca gaaagaagag aaagcggatg accagattga 1251841 tgatagtgac aaagataaaa aaataaagga atcagatgaa aacacaaata ccgaaaaaga 1251901 tggggaccat gagcaaaccc caatacaaga tcctcaagat aaaggaaatg aaaataacgg 1251961 cgctgacaag ggccaaagcc aatatcacag ggactggaac aatggtgaac aaggcaagaa 1252021 ccgttcttcg tccagaaggg ataacgcttc agaccgacgt aatccaaacg gctacagcag 1252081 tgataatcat tcagctaaaa atgaagattc gccgagtgcc cccggcgaat aaagacctga 1252141 atttatttag ttgtgccatt taattgtgat tgtgcttgct gtaccagccg ctttgtcatt 1252201 tctccgccta cagagccgtt agcgcgtgcg actgtatcag aaccaaggtt cacaccgaat 1252261 tcttgagcca cttcgagttt aaattggtct agtgcctgct ccacccctgg aacaacgagt 1252321 ttatttctgc tcgccatctt tttcatctcc tttttcgata aagaaattct taacgcgtat 1252381 ttagtttgaa atatacgggg tttatttatg ctggcaattg ttgtggagaa aaataaaacc 1252441 ccggcctctg agccggggtg gcgcagacta tagaatgtct gctgtcattt tatgtgcggt 1252501 tgcctgaata tggaatgtca aaatggagag gactgtaatg gcgataatct gtctgatttt 1252561 aagccattgg ctgtcattca gttcttcaaa acggtgacgg agacgctctg tctcctgttc 1252621 ggcgatctcc tgcagatttg attctttcat agaaggagta tcttggtgat ggatggcatc 1252681 aagcacatat gcgcagcttt cataataagc aatcgggctg atgacatcat cagatctgtc 1252741 tgagattgtg ttaaaggcca cttttaaaat agcccgtatg tgttcaaagt cataaatgga 1252801 ttttaaatca cgtacaatta aaagaataac tgcctgttca attgagtatt ttttgcccag 1252861 ctcagggtgt ccgatcagat ctttgatatc acgctttacc cagttttgaa tcgcggttga 1252921 ctttaacgaa gtcagctcgc ataagttgcc aagctctacg atttcatttg tagacagacc 1252981 gtattctttt ttctgttttt ttcgttcgta tcttgtaaga aattcaggaa tttctagatg 1253041 attggctgct ttttctgctg acatgttcgc tgattggacg agaatgtcga gcgggctatg 1253101 ttctccttgt ccttttaggg aatagagcag ccgcaccata tcggttcgag agagtttaaa 1253161 aatgttcatt gttcacctct ttaaacaatt tgacgcggat ataggtctat gtataagttc 1253221 aaaattcaag cgtcagcaaa ttacattaac atcatacgtc gaattccttg cattttcaaa 1253281 tggatgtttt ataatttaaa tatacgggtt cttttgaact taaaataacg gaggttgtta 1253341 tggcgaaaag aatttttctg tttattctaa cgaatatttt ggtgcttaca acaatcggga 1253401 tcgttttgtc tgttttaagc tctgttacag gagtcgggac gtactttaca gctgatggcg 1253461 gtatcgatcc aatggcgctt cttgtgttca gtttagtcgt tggatttgtc ggttccttta 1253521 cgtctcttgc gatatccaga tggatggcaa agacgatgat gggcgtcaga gtgctgaatc 1253581 cgaaaaaaca ctcgctcagc tatgaggaac agcaattggt tgatcgtgtt cacagattaa 1253641 gccgctctgc cggtttaacg aaaatgccgg aagtcgggat ttaccgttca cctgaagtaa 1253701 acgcgtttgc gactggaccg tcaaaacgcc gttcacttgt cgcagtatcg tcagggctgc 1253761 tggagcagat ggatgacgca gcagttgaag gtgtgcttgc ccacgaggtc gcgcatatca 1253821 caaatggtga tatggtaaca atgacgcttt tacaaggtat cgttaatacc tttgtcgtct 1253881 ttttatcgcg tatcgccgct tggatagcaa gccgttttgt caaagaagat ctagcgccga 1253941 tcgttcattt tattgcaatg attatttttc agattgtctt ttcgatactt ggcagcctgg 1254001 ttgtgtttgc gtattcacgc catcgtgaat tccatgctga caggggagga gcggatcttg 1254061 ccggcaagga caagatgatt catgcgctgc ggacgcttaa aagctattct tcccggattt 1254121 tggaagacga tcagacagct gtccaaacgt taaagattaa tggcaagaag cgctcttcac 1254181 ttttctctac tcatcctgat ttagatgagc gaatcagacg gctggaagct aaataataca 1254241 aacacattgt tcctctgaga gaattctcag aggtttttta ttttatccat tgactaaaat 1254301 cataaaaaaa taagcaagtt aagaaaatgt ttcgtaaaag cctttaaaaa tggacctaat 1254361 atctttagaa taattaccgt acttaaaaag agaggcagaa ggattttaca tgagattaaa 1254421 gtttggaaaa ttgatacagg ccttgtcacc ggcccagctg atcgcattat attattttct 1254481 tgcagttact gtggccgtta tattgctgag tttgccggcg gcccataaac cgggggcgga 1254541 ttggacgttt attgatgcgc tttttacagc tgtcagttca gtcagtgtaa cggggctgac 1254601 agttgttgat acagctgata cattcagcac aatagggatt tttatattag catttgttct 1254661 gcaatttggc ggaatcggaa ttatgacgct cggaacgttc atttggctga tcatgggaaa 1254721 acgaatcggg ctgaaagaac ggaagctgat tatggttgat caaaaccaat cccagttttc 1254781 aggaattgtc aatctgatga agcaggtact gtttctgatc ttgtggattg aattttttgg 1254841 cgggctgata ctcggcacat atttcttaac ctactatgac tcctatcagg aagcctattt 1254901 acacggattt tttgccagta tcagtgcaac gacaaacggc ggatttgata ttaccggtaa 1254961 ttcgatgatt ccatttcgcc acgattactt tgtgcagttt attacaatgc ttttaattat 1255021 atttggagcg attggatttc ccgtgcttgt tgaagtaaag gatttcctgt tttcaaagca 1255081 tcggcgttat ccatttacgc tttttacaaa gatcacgacg attacgttcg gctcacttgt 1255141 cttgtttgga gccattggca tctttgccct ggaagcaaac catgcgttcg caggaaaatc 1255201 atggcatgat attttgtttt tgtccctgtt tcaatcaacg gcaacccgaa gcggggggct 1255261 ggcaacaatc gatatcagcc aattatcaga ttccacactc ttttttattt gtgcgctgat 1255321 gtttattgga gcgtcgccaa gctcagtcgg gggaggcata aggacaacga cttttgcttt 1255381 gaaccttctt gcgctgtttc attttgcccg cggcaataag gccgtaaagg tattcaaacg 1255441 ggagcttcac cctgctgact tgatgaagtc gcttgttgtc acgatgatgg cgatcctgct 1255501 cgtttttggc gcgacactca ttctgaccat tacagaaaaa cattccctgc tggagctttt 1255561 gtttgaagtg tgctcggcat tcggtacaac cggcctatcg cttggaatta cggcagattt 1255621 gagcagtgtt ggaaaatgcg tcattatgat tgtcatgttt atcgggcgaa tcggcatctt 1255681 gaccttcctg tatctgatcg gaagaaagga aattgaagcg aattatcact atccgaagga 1255741 aagagtgatt atcggatagg caaaacaccg catattttgc ggtgtttttt gattaccaaa 1255801 aaaaagatgt gtgcctcctg ttcagttgga gaacctaact ccgacaggtg caatttacgc 1255861 tcctgcatct taaaatgtct gaaaattggc gaggaggatt cgtatgaagc gtaaagctga 1255921 agtgaatgaa gccattaaaa ataacaatac acctaccgag agcatggacc ccaattcata 1255981 taagacacaa tatcatgacg accccaattt tagaggggca aaccgcaatt ccaaacaggg 1256041 ccagcaggga ggcatgtaat tgtgaagaaa aaccgtcata gcagagacat gcaaaatcat 1256101 aaaaagccta tgaataaaaa ggtgctggag gaagaattct caagtgaact cggggattac 1256161 aatgccggaa agatcatcga aacgctggaa gtcaccaagc ctgaaaagaa aaaagaaaaa 1256221 aacaaaaaac aacaataaaa aagacctctt aggcggcgtc ccgcttaaga ggtgcttttt 1256281 ctattttaaa taagcatttt tgcccgttcc tctgacaaat tgcaataagc ttgtcatcct 1256341 cagctcaatg aatggctgag cgactgtctt aacaaagttg ctggagagga ctgatgtcag 1256401 ggctgctgtt aaaagcaaga ggatcactaa gctttgatag tcagtaagcc aatcctcaag 1256461 cccgacctgc cgtaatgtct taataataaa cccgtgaagc agatacacgt aaaatgtccg 1256521 ggttccccat ttggtaaaga aataccgttt ttgcggaacg agcgctaaaa agctgaaggt 1256581 tgccccaaag gcgagtacat accagccgat tcgggatagt ccgcttacca gggtaacgtc 1256641 tccaaatgaa gaatacggtt ttgaaccaaa cagaaaagaa tagtcaaaat cgatgcccca 1256701 gcagatgacg aatactgcgg caagcactcc gagcgcaatt tgtttgccgc gttttgatct 1256761 caataaatca aaatgatgtt tatttaaata aaaaccgaca aggaacatcg gtaagaatac 1256821 gaatgtccgt gacaagctca gcgtgctgct gacaaagtcc agataaccga tcagcacggc 1256881 gattccgcag ctgacaaaca gcgcccactg ctttgaaagc tttgaaaaag gatataggag 1256941 caggttccaa aagaataagc ttacaagaaa ccataacgac cattgcggat caatcgggtt 1257001 cacatttgcc atgctttcat cttgcataat gtaataaaag acggaataaa taatttggaa 1257061 aatcaaatac ggaataatca gcttgaccgc cagctttttt acatatcccg cccgtttaaa 1257121 gcctttcgcg aaataaccgg atacaagaat aaatgcaggc atatggaatg tgtaaatgaa 1257181 cttgtagagg tagagcataa aatgattatc attaataaag gaacgaagga tatgaccgaa 1257241 tacaacaagg aatatcaata aaaattttgc gttatcgaaa taactgtccc gcgatttact 1257301 catagcatca ccttctcttt catcagtcac taagagatta ttccctgctg gtacatattt 1257361 taaaataaaa gatgaaaaag gaatctaaaa aaatgctgat tgttaggtcg atgtaaagtg 1257421 acggtaagga tcgtagaaaa tgtcttcgta atgtaatgac gctgaaattt tctgaaattt 1257481 atagggcaaa tgaaggaagt tcccgcattt tgtagaaata ttgagggata ggttttgaag 1257541 aaggagtgta catgcatgga aactcttggt gtccagacaa actcggagct gcgagaggaa 1257601 ctgaatcgcc tcaaagaaga aaacgcgcga ctgaaaaagg aattgaatca gcatcaagtg 1257661 attgtcaaca atacgctcga tgctattttt atttgtgata acgaaatgcg gattgttcag 1257721 gcaaatgaag caacagaaag gatgcttcaa gttgactcgg aagatttgaa aaagcgttct 1257781 gttttggatt ttttgttttc aatcccaaag gatgaactga atctttccgt aaagaagttt 1257841 tttaaaaaag gctttctgtg gaaggaggtt ccgatcaggc ttgattgcgg ggcaacaaaa 1257901 tacatagagt ttctggccaa aagaggtatt ggtgaggatt tcttttttgt tgtcatgagg 1257961 gacatatctt ctaagaagat tctggagcgg gaattctcta tgaatgaaca gctttttaag 1258021 gacttgtttg acagagcagt tgacggaatc gtcctgtttg ataaagatgg cggttttatt 1258081 gatgcaaatt tgtccttttg taaaagcttt gaaatcaatc ataatgagct gtctcattta 1258141 tctttgtatg agttcataga cagcggctca cgaaaagatt tcgacaatat ctggaaggcg 1258201 ctcaaccgca agggaaaagc gaagggggag ctgcctgtca agcttcgttc aggagttcaa 1258261 aaactatttg aattcacgat tacatcaaac atcatcagcg gtttttatat gtccattatg 1258321 agggatatca cagagaagcg gtctatggag ctgcagctct ttaaaagtga ggagcgcttc 1258381 agagaaatct ttgaaaatgc aatggacgcc atcatcatct ggtcgaatga cggaagaatc 1258441 gtaaaagcga atcaatcagc ctgtaaaatt tttgagctgc cgatgaattt gctgttgaaa 1258501 agaaagctgt gtgattttct cgttgactcg cagcagaaat acagcataac gaagaggaaa 1258561 tacgcaaaat acggagagat cagagaagag ctgctgtttc aaatggggaa cggccaattc 1258621 aaagagcttg aatttacttc aaaacggaca atccttgaaa atcagcattt gacgatctta 1258681 agaaatgtaa gcgacagaaa gcggatggaa aaggagcttc gggaaagcga gctgaaattc 1258741 agaaaagtgt tcaacggatc aatggacggc aatgtattgt tcgacaatca atacaggatc 1258801 atcgacgcca acccgttagc aagccatatt ttgggcctgt cacatgaaga gatcaaacag 1258861 cacagcctgt tagatattat ttctgcttat gaaatagaaa atttggcatc accggcaagg 1258921 cagattaatt ttgatgaaat ggacaacgaa attccatttt tgctgagcag cggtgataac 1258981 agaaaactcg aattctcatt taaacggaat attattcaaa atatgaactt ggctatcttt 1259041 aaagacgtaa cagagcgaaa agaattggag gagcgcctgc gcaaatcaga tacccttcat 1259101 gttgtcggcg aactcgcagc cggtattgct catgaaatca gaaatccgat gactgctctt 1259161 aaaggcttca ttcagcttct gaaagggagt gtcgagggag actacgccct ttacttcaac 1259221 gtgatcacct cagaactaaa gcgcatcgaa tccatcatca ccgaattctt gattttagcc 1259281 aagccccagg ccattatgta tgaggaaaaa catgttaccc aaattatgag ggacacgata 1259341 gaccttctaa atgcgcaagc caatctcagc aatgtacaaa tgcaacttga tttaattgac 1259401 gacattcccc cgatttactg tgaaccgaat cagctgaaac aggtttttat caatatatta 1259461 aaaaacgcca tcgaagtgat gcctgacggc ggaaatattt ttgtaacgat aaaggcattg 1259521 gatcaagatc atgttctaat ctccttaaaa gacgagggaa tcggaatgac agaagataaa 1259581 ttaaagcgac ttggtgaacc gttttatacg acaaaggaac ggggaactgg acttgggctt 1259641 atggtaagct ataaaattat tgaagaacat caaggcgaga ttatggtaga aagtgaagaa 1259701 gggaagggca ccgttttcca tattacgctt cctgtcagac agaatgctga agaaagaagg 1259761 aatgatgaat gaactactat acgacagccg aaacgccgct cggtgaactt atcattgccg 1259821 aagaggagga ccggatcact cgtctatttc tcagtcagga agattgggtg gattggaaag 1259881 aaacggttca gaatactgag cataaggaaa cacctaatct tgcagaagcg aaacaacagc 1259941 ttcaagaata tttcgcaggc gaaaggaaga cattctccct gccgctcagc caaaagggca 1260001 ctccttttca gcaaaaagtg tggcaagcgc tggagaggat tccatatggc gaatcccgaa 1260061 gctatgcgga tattgccgct gctgtcggca gtccgaaagc ggtgcgcgct gtcgggcagg 1260121 ctaataaacg taacgacctg ccgatttttg tcccgtgcca cagagtgatc ggcaaaaaca 1260181 gtgcgttaac aggatacgcc ggaagcaaaa cggagatcaa agcatttttg ctaaacatcg 1260241 agcgaatctc ctataaagaa aaataaaaca tatggcacgt tccctttttt cacggccgac 1260301 atatcatttt attaagttaa aaaagttggt ctgatgaaaa aggaggacaa agcaattgaa 1260361 gccgagccgc tctgagaaac ttgccgtttt tgccgaactg tttgtgaaac tgcatatctt 1260421 atcaagcgct caaaaagatg aaatcatcaa tgttaacaaa aagaaacaaa aaaaccgctg 1260481 actcggctcc aaatgagcaa agtccagcgg ttttttaatg caccttttct cctttaaaca 1260541 gctgttcaat ctcttcttca tagtttccgg tcataatccc tttttctgtg atgattcctg 1260601 aaatgagatc atgaggtgta atgtcgaaag cgggattaaa gacaggcaca ttggatggag 1260661 cggtccgaac tccggaaatc tgcctgactt cctcgggatc tcgttcctct atcgggatat 1260721 cagcgccgca tttgaccttt gtatcaaatg tagataaagg tgcggcgaca aaaaacggaa 1260781 tatcaaaggc gtttgctaaa atagcaagac cgtatgtgcc gattttattt gccgtatcac 1260841 cgttctttgc aattcggtcg gctccgacga taacagcgga aatttgtttt tccttcatcg 1260901 tatgggcggc catgctgtct gtgatcagag tgacatcaat gcccccctgc atcagctccc 1260961 aagcagtaag gcgtgaacct tgcaggacag gccttgtttc acaggcataa atgtgtaatc 1261021 ccaaatcttt ttgtttggcc aagtaaaacg gagctagcgc cgttccatag cggcttgtcg 1261081 cgattgagcc ggcattgcag atcgtcatga tcctgtcgcc ttttttgaaa agctgcaggg 1261141 cgttttggcc gatcaaccgg cacgtttcct catcctcgac ctgaatctga atggcttcat 1261201 ggacaaggtt tgtttttgct tcatttacgg aaatcgcgtt ttcgaccgaa tgactcagtc 1261261 tctcaagcgc ccatgacaaa ttaatggcgg taggccgtga gctgtttaaa tattgtttga 1261321 tgtcttccag tctgcggcgg aattccgtga cattgtctgt ttcaatgtct ttggcagcaa 1261381 gcgccagtcc gaaggcagct gtaatgccga tcgccggagc gccccttact ttgagcgtga 1261441 caatcgcatc aaatacatcc tctttcgtcg tcagctccaa atattccgtc tcatcaggaa 1261501 gcttttgctg atttaaaatg gtaatagctg tttctttcca ttcaacagaa cgtggaacag 1261561 caaatgaatg ggtcatgaat agatcattcc tttacaagta acttaaataa ttcaataaca 1261621 tctgttatcg ttttgaattc cgaacgtttt tcgataaagg ctgtgccggt ttcgagcgcc 1261681 aagcgttttc tgccgattcg tttatcaaac ggcacgatcg tatccaggtc agctacatgg 1261741 gcaaggccga tcgtgcgtcg tatcagctca cagcccgcaa atccgattgc ttcttcaaaa 1261801 atatggctga gcgtatcagt gaggtaaccg tcgatgttgg cgtaaacatc cagactgtcc 1261861 ttctgccagg cttcactaaa cgtctcttca aacgtttccc agacctggtt gacatgttca 1261921 tataacggct ctctgtcagc cccgtcacgg ctgagtgcgt tcaaaaataa gttggcgata 1261981 aattgcccta catcaaagcc gatcggtccg taaaaagcaa actcaggatc aatcaccttt 1262041 gtttcgtgct cacttgcgaa aatgcttcct gtatgcaaat caccatgaat caacgtttct 1262101 gcagacgtta aaaatgactt tttcagctta gcggcttcga ttttaacgct gtcattattc 1262161 caaagctttt cgacaaaagg acgaagctct tcttcaaaat catttgtgtc atggtcgaag 1262221 aaaggatctg taaaaacaag tctttccgta atgtcgcata gctctggatt tgtaaactgt 1262281 ttaacaagct gttttttcac cttaggttca agcgcgtaat ctgatgagta gaaaagtgtt 1262341 tttcctaaaa attcaccgat gtgctgcgac agatgaggat agttttcacc ctcaatgagt 1262401 ccttttcttg cgatcttgag gtgagagaga tcctccatga cggtaaccgc catttccgta 1262461 tcagaataaa acactcttgg aaccaggtga ggcacatgct cgccctgacg gatgagagcg 1262521 ctgctttcga ttcttgcacg gtcgattgtc agcggccagc tttctcccac cacttttgca 1262581 tacggaaccg cctgtttaat gatcaatgct ctgtcatgtt cttgatcata aatatgaaaa 1262641 acgtaattta agttgccgtc tccgatctcc tggcatgtca gcgtgctttt gcttggaaat 1262701 aggccaagct tcaccgccaa cgccacagcg gagctttcat ttaacgtttc gtataaaggt 1262761 gtttttgtga ctcccatcat cataacctcc aattatgtaa ttaattaata tgtggccgta 1262821 aaaaagcctc cttctcagag agaaggaggc ttaacatcta tgtccgcctc tcttatctct 1262881 cagatcagat ctgaatggaa ttagcaccgt gccttaagag accagcgtct cggcgcgaaa 1262941 aaaatgcgcc ccatttcaca atggaattac ggtcggttgc ttttggggtc aaaaggccaa 1263001 atccctcgcc caactctcga taagagaata tattcacttg tttgacaatt ctaatttatc 1263061 agttgatgaa catggtaaca ggtaatttag ttagttgtca atatattttt taatataaat 1263121 cttttctgat atcatcgaaa acaggaatgc tctcccgaac ttctgcgctt tcttgaaggt 1263181 cgatttccgc tcggactatg ccttcttccc ggccgccttc agcaagtaca cgtccccatg 1263241 gatcaataat caggctatgt cctgcaaatt cattatccgg atttgaaccg gtacaattgc 1263301 aggctgcgac aaagcattgg ttttcaatgg cccgcgcaat aagcaggctt ttccaatgat 1263361 caaggcgggg aagaggccat tccgcagaaa taaacagcac gttggcgcct tttgtcgtat 1263421 gttttctgat ccattccgga aaacggatat cgtaacagat caatccagag cttttgacgc 1263481 cgtcaagctc aaagtatccg tcttcggaac cggctgataa atacagatgc tcatccatca 1263541 gctgaaaaag atgggctttt ctgtactctt taatgatttg cccttcctta tccgcgatgt 1263601 acattgtatt ataaacatca gaattcttcc tgacagcgac cgatccggcg acaatatgaa 1263661 caccatgttt ttttgccgtt ttcttcagcc agctctgagc ggagcggccg tcttcgtcag 1263721 cgagttcatc aagattggcc agatcatatc cggtcgtcca taattcaggc agaacaagaa 1263781 catcagcatg tttgctttct ttttcgatga aaaattcagc cttttttata ttttccgaag 1263841 gttttccgta tgaaatatca aattgaagac aagatatcgt ccatttcatc tttttaacac 1263901 cccaaatttt tctttacttt tttcatttaa ccatatatga tgatggacta tcatttcaag 1263961 atttttttag aaggtgagaa tagatgaaat ttgaacagtc tcatgtattg aaggaattgc 1264021 ctaaacaatt cttcgcttct ctggtgcaga aagtgaaccg aaagcttgca gaaggacatg 1264081 acgttatcaa tctgggacag ggaaatccag atcagccgac tcctgagcat attgttgagg 1264141 agatgaaacg agctgtcgct gatcctgaga atcataaata ttcgtctttt cgcggctcat 1264201 accgtctgaa gtcagcggct gctgcatttt acaaaagaga atacggcatt gatctggatc 1264261 cggaaaccga agtcgctgta ttattcggcg gaaaagccgg tctagtcgag ctcccgcaat 1264321 gcttgttgaa tcccggtgat acgattttag ttcccgatcc gggttatcct gattactggt 1264381 cgggtgtcac acttgcaaaa gcaaagatgg aaatgatgcc gctcgtaaag gacagagcgt 1264441 ttctccctga ttacagcagc ataaccgctg aaataaggga acaggcgaaa ttgatgtatt 1264501 tgaattatcc gaataatccg actggagctg ttgctacttc cgagttcttt gaagataccg 1264561 tgcgttttgc ggctgaaaac ggaatctgcg tcgttcacga ttttgcttac ggcgctgtag 1264621 gatttgacgg ctgcaagcct ttaagctttt tgcagactga aggtgcgaag gatatcggaa 1264681 ttgaaattta cacgctgtca aaaacgtata atatggcagg atggcgggtt ggctttgccg 1264741 tcggaaacgc ttcggtcatt gaagcgatca atctttatca agaccatatg tttgtcagtc 1264801 ttttcagagc gactcaggag gctgcagcag aggcactgtt agccgatcag acgtgtgtgg 1264861 cagagcaaaa tgccaggtat gagagcagga gaaacgcttg gatcacggca tgccgggaaa 1264921 tcggctggga tgtaacagct cccgcaggtt ctttttttgc atggctgcct gtgcctgaag 1264981 gctatacttc tgagcagttc tcagatcttt tgctggaaaa agcgaatgtg gcagttgcgg 1265041 ctggaaacgg cttcggtgaa tatggcgagg gctacgtcag agtcggactt ttaacaagtg 1265101 aagaaagact taaggaagcc gcttatcgaa ttggcaaact gaacctgttt acccaaaaaa 1265161 gcattgacaa gaccttataa cgatgggata attcaaaata atttataaaa tctatatttt 1265221 cttatcaaga gcaggcagag ggacgagccc gatgaagccc ggcaaccgac ttataaagca 1265281 cggtgctaat tcttgcagct agcggctgag agataagatt cggacgagaa acgaaacctc 1265341 tttagacgcg attgcagttt gaagaggttt tttgatatgg atgaaaatga aaggagctct 1265401 ggcatgagtg agttattagc gacatatctc ctgaccgaac cgggagccga tacagagaag 1265461 aaagcagaac aaatcgcaac aggattgaca gtaggctcct ggactgatct gccccttgta 1265521 aaacaggagc aaatgcaaaa gcacaagggg cgggtgataa aagttgagga gagagaggga 1265581 actgctgcat cagaaaaaca agcggtcatc acaattgcct atcctgaaat caatttctct 1265641 caggatattc cggctttgct gacaacagtg tttggcaagc tgtccctgga cggaaaaatc 1265701 aaattaatcg atcttcactt ctctgaagca tttaagcgtg cactgccggg accgaagttt 1265761 ggcgtatacg gcatccggaa gctgctggga gagtttgaga gaccgctgtt aatgagcata 1265821 tttaaaggcg taatcggaag ggacctgagt gatattaaag aacagctccg gcagcaggcg 1265881 cttggcggag ttgacttgat taaagacgat gaaattttct ttgagactgg tctagcgcct 1265941 tttgaaacaa gaattgcaga aggaaagcaa atattgaaag aaacgtatga acaaaccgga 1266001 cataaaacgc tgtatgcggt gaatttgacc ggacgtacgg ctgatctgaa agacaaagcg 1266061 agacgcgccg ccgaattggg agcggatgcg cttttgttta atgtcttcgc ttacggcttg 1266121 gacgttatgc aaggccttgc agaagatcct gaaatcccag ttccgattat ggcgcatcca 1266181 gcagtgagcg gagcgtttac gtcttctccg ttttacggtt tttctcacgc tcttttactc 1266241 ggaaaattaa accgatattg cggtgctgac ttcagcctct ttccgtctcc atatggttcg 1266301 gttgcgcttc caagagcaga tgcactggcg attcatgaag aatgtgtgag agaggatgct 1266361 tttaaccaaa catttgctgt tccgtcagca ggcattcatc ccggcatggt tccgctatta 1266421 atgcgtgatt tcggcataga ccacattatt aacgccggag gaggcgtaca tggacatccg 1266481 aacggtgccc aaggcggggg gcgagcgttc agagctatta ttgatgcggt cctagaggcc 1266541 cagccgattg atgaaaaagc cgaacaatgc aaggatctta agcttgcgct agataaatgg 1266601 ggaaaggctg aagccgtatg acgactcgaa aaccttttat tatttgtgat tttgacggaa 1266661 caatcacgat gaacgacaac attataaata tcatgaaaac atttgctccc ccagagtgga 1266721 tggcattaaa agacggcgta ctttccaaaa cgctgtcaat caaggaaggt gtcgggcgga 1266781 tgttcggcct tctgcccagc agtttaaaag aagagattac aagttttgta ttggaagatg 1266841 caaaaatcag ggaaggcttt cgggaatttg tagcatttat caatgagcac gagattccgt 1266901 tttatgtcat aagcggtgga atggactttt ttgtatatcc tttgcttgaa ggcattgtgg 1266961 agaaagaccg catttattgc aaccatgctt catttgacaa tgactatatc catattgact 1267021 ggcctcattc ctgcaagggc acatgcagca atcaatgcgg gtgctgtaag ccgtcggtca 1267081 tccatgaact ttctgaaccg aaccaatata tcatcatgat cggtgattcg gttacagatg 1267141 tggaggcagc aaagctgtct gacctatgct ttgcaaggga ttatttatta aacgaatgcc 1267201 gggagcaaaa cctcaatcat cttccgtatc aagattttta tgagatcaga aaggaaattg 1267261 agaatgtaaa ggaggtacag gaatggctgc aaaacaagaa cgctggcgag agctcgctga 1267321 agtaaaacgg gaattggcag agagagattg gtttccggcg actagcggca atctgtcaat 1267381 taaggttaca gatgagcctt taacatttct cgtcactgca agcggaaaag ataaacgcaa 1267441 agagacggtt gaagattttc tgctggtcga tcaaaacgga gagcctgctg aaagcgggca 1267501 ttctctgaaa ccgtcagcag aaacgctttt gcatacacat ttgtacaata aaaccaatgc 1267561 cggatgctgc ctgcatgtcc atacggtaaa caataatgtg atttcagagt tatacggaga 1267621 ccaaaagaaa atcacattca aaggccagga aattataaaa gcactcggct tgtgggaaga 1267681 gaacgcagaa gtgaccgttc cgattataga aaatccggca catatcccga cgctagcggc 1267741 actgtttgcg gaagagattt cagaagattc aggagctgtt ctgatccgaa atcatggtat 1267801 tacggcttgg gggaaaacag catttgaggc aaaaagagtg cttgaagcgt atgaattttt 1267861 gttcagctac catttgaaat tgaaaacact cgagcatcag ctggttaaat aaaaggagga 1267921 attgaaatgg ctacaattcg aattcatgat gaggcaaata caacgattga aaatcaagag 1267981 gaagtggcaa gctttctgga cagtcaagag gttatttatg agcaatggga tatcacgagg 1268041 cttccggaac atctctcaga gaaatatgac ctgacagaag aagaaaaaca gcaaattctt 1268101 gataccttcg aaactgaaat taaagatatc tcaacccgcc gcggctataa agcacaggat 1268161 gttatttcat tgtcagacag caatccgaaa cttgatgaac tgcttgaaaa ctttaaaaga 1268221 gagcatcacc atacagacga tgaggttcgt tttattgtaa gcggacacgg tatttttgtc 1268281 attcaaggcc aggacggcac gttttttgat gtccgtttaa accctggaga tttaatctcc 1268341 gtgcctgaga atatccgcca ttacttcacg cttcaggagg accgcaaagt tgtcgcggtg 1268401 agaatttttg tcacaactga aggctgggtt cctatttatg aaaaagacag cgtgaatcaa 1268461 taagcgtgag atagccccgt tcatcgaacg gggcttttta tatttattgc aaacgccact 1268521 tttcatattg tgacagttct tttttaatca gtgtccaaat caaacctaaa acagctgcat 1268581 cgtcaatgaa tccaagaccg aggattacgt ctggaatgat atcgagcggc atgacgatat 1268641 acaggattgc ggcagttaac agcaaaagtg ttttaacctg tgaacgaggg tagtcgccat 1268701 ttcgccaatc gcgaagcatc tgaaaaaaag tagtgatgtg ctggatacat ttttttcggt 1268761 ttttcctctt taaaatcgct tttccgcctg ccgctccgag cattattgct ttctttttct 1268821 tcattgggca tacctcctgc ctggcggcgt gtttaagata ttcttcacct gggtattgtt 1268881 cttctaatcc tatcaatata tctattatac ctgaaaaatt aacttattta atgaaaatat 1268941 gtttacaaat aaagtataat ctgtaataat gcacaataac ccaatcaaac ttgtttccta 1269001 tttcttagcg gcgaggggtg aagtgaatgg gcggttcttc tgaacaagaa agattgttgg 1269061 tgtctattga tgaaaaaaga aagttaatga tagatgccgc tagaaagcag ggatttacag 1269121 ggcatgacac gatcaggcac agtcaggagc tggattgttt aataaatgaa tatcatcagc 1269181 ttatgcaaga aaacgaacat tcccaaggga ttcaaggcct tgtaaagaaa ttaggcttgt 1269241 ggccccgcag agatgttatg ccagcatatg atgcaaataa atagcggcct atcagatgca 1269301 tatataaaga gagagctttt cggaagcgct ctttttttct ggaaaaaatt catatgaaag 1269361 agggaactaa tgaaggaact ggcgattctc attaccgaaa tggtcaatca atttcatgat 1269421 gcttttattt ccttatgcgg aatatttggc attcatttaa ctgacaaaga aatgcatttt 1269481 tgggtgatcg gcatttttgg catattcttt ttcggcgtca ctcacgctgt gtttacatgg 1269541 ctttctaaat ggagtatgac agccttgtcc tttatctata ccgttacagt catcattgtc 1269601 atcgtatttg cgattgagat tcagcaaaag gtgacgggga gagggaatat ggagttttta 1269661 gatgccacgg aaggtataaa gggtttttta gtatttttta tgtttttttt gcttttgaaa 1269721 atgctgttgc gtttcatcaa aatccttttt tctggaagac cagcaagcaa atcgaatggc 1269781 aatgcccgat cacgaagata aaaaaccctc ctgacatggt caggggggct atgatgcgga 1269841 tacggggagg gtgatcgtca cctctgtgcc tcttcgcccg ctgattgtta ttttgcttct 1269901 gtgcctcttc gcccgctgat tgttattttg ctcctctgtg cctcttcgcc cgctgattgt 1269961 tattttgccc tctgtgcctc ttcgcccgct gattgttatt ttgctcgcac tttgatttta 1270021 tcatcttcta aaatcacgtg aaaacttgtg atctcgccat tatcaagcag cagatcggtc 1270081 atttcatcct caacccattc ttggatggtt cttctaagcg gacgtgcacc gaatgaaggg 1270141 tggtagccca gctcagcgat tttttctttc gcttcatctg tcacattcaa gctaatgccc 1270201 cgttccgcca atgtttcttc aagttctcca agaagaaggc tgacgatttt gacaagatgt 1270261 tctttttcca atgagcggaa ctcaataatg ctgtcaaaac ggttgaggaa ctcaggttta 1270321 aagaacatgc tcagtgaatc aattaatgtt tgttcttcga tgacactgtc atctgattgg 1270381 aaaccgactt tcgtttgttt ctcaccagca cccgcattac ttgtcatgat gatcacagtg 1270441 tctttgaagc ttacagttct gccttggctg tctgtcagac ggccatcttc cataatttgc 1270501 aggaacatat gctgaacgtc tgggtgtgct ttttcaatct catccagcaa cacaatgctg 1270561 taaggattgc ggcgcacctt ctcagttaat tgtccagctt cctcatggcc gacatatcca 1270621 ggcggtgaac cgataatttt agatacggcg tgtttctcca tgtattcgct catatcgagt 1270681 cggataatag cgtcttttgt gccgaataat tcatctgcca gtgttttaga aagctctgtt 1270741 ttccctacgc cggtaggacc gacgaagagg aaggagccga ctggtctgtt tttggatttt 1270801 aatccggcgc ggcttcgtct taccgctttt gccacttttt gaacagcggc ttcttgtccg 1270861 atcacgcgtt catgaagttt tgcttcgagt tctttcattt tcgtttgttc gtctgcctgc 1270921 agtttgccga cagggatgcc tgttttttgt tcaacaattt cctgaatgtg ctcagcttcc 1270981 acagtgacag cggtatgagc ggaggagctg ttcagttttt tctccaatgc gagttcttca 1271041 tcacggagtt ttgccgccag ttcgtaattt tcttcttcca gggcttttgt tttttcggct 1271101 tcaattgcag ttaagcgttc agcggcatcc tcatcattca gttcatcaat taacaggttg 1271161 gcttttgaac ctgcttcatc taataaatca attgctttat ccggcaggtg tctgtcctga 1271221 atgtagcggg atgataaagt gacacatgct ttgattgctt catcactgaa tgttacgcca 1271281 tggtacgcct cgtatttgtc tttaatccct tgcagaatga ggatagcctg ttcaattgaa 1271341 ggctcctgca ccatgacagg ctgaaaacgt ctttccagcg cggcatcttt ttcgatttga 1271401 cgatattctt tcagtgttgt cgcgccaatg acttgcagtt cgcctctggc tagggccggt 1271461 ttgagaatgt tgccggcgtc cattgatcct tctgcagagc ctgcgccgac gagaaggtga 1271521 atttcatcaa tgaacagaat gacatttttt cgttccttca gctcagtgat cagctgtttc 1271581 attctctcct caaattggcc tctgatccct gtgtttgcaa caagagatgc aacatcaagc 1271641 aagtatagct ctttgttttt tagtttgttt ggaacatcac cttcagcaat ttttaaagcg 1271701 agcccttcag cgatggcagt tttccctaca cccggctcac caataagaac cggattgttt 1271761 ttgtttcggc ggtttagaat ttcgatcact cgcgccactt catcatcacg gccgatgacg 1271821 ggatcaatga gaccggcttt tgcaccgttt gtaatatttt gagccagctc atcaagcaac 1271881 cctttttttt cgctttgttt tgctgcgctc tgttctttcg gctggaatgc ctgttcaaac 1271941 ggaaatccga aagattgagg acccatactc attgaaggtt tacgggtcag ttcgttatag 1272001 caagtttcac aaagaaccat ctgtttatga acggaattta tttgcatgtt aaggcgaatc 1272061 gtcgcctcgt tttgatgaca atgttgacaa cgcatttgcc aaaacctcct taataatttg 1272121 atcatctttg accaatgaaa gtgaataaaa aggtctattg ggtttgacct tctttgacta 1272181 ttagtatacg gcaaacttaa cggcattcaa accaatatgc tcaaagcaga ctgaatattt 1272241 gactatcttt gaccaattga tttttaaaaa aggccggttt gtttgaccaa ctttgattaa 1272301 tagtatactc tgactatctt tgactttcaa gtcttatgca caaaaatttt tgatttgtta 1272361 caaagtaaaa catgttttct tcgtcttttc aaggaacttg tctcataggt tataaaaagg 1272421 catatatgga caaaactgcg gttcgttcgg agggaagaaa tggaacaatc aaaagggtct 1272481 gcaagtcagc ttgcttttgt gtatgtcggc acagtagtcg gagctggatt tgcgactggg 1272541 agggaaattg ttgagttttt tctgaagttc ggctggttcg gttttttcgg cattctcgtc 1272601 agcggcggaa tgtttacgtt actgggggcc aagctgatga tcatttcaaa gcgaatcaat 1272661 gccaagtcat atcaagaaat gaacatattt ttgttcgggg cgacggctgg gcggattatc 1272721 aatgtattta tgctgtttgt tctccttgga gttacatctg ttatgctttc aggggcaggg 1272781 gcgctttttg aggaacagct ggggatgtcc gctcagattg ggatgctcat tacaatcggt 1272841 ctgagtttaa ttgtgatgac tagaggagta aaaggcattt tcggtgtcaa tgtgtttgtt 1272901 gttcctcttt taatcatctt ttcaatgatt gtggtggccg actcttttat attcagcgaa 1272961 tcacgaaacg cagctcagtg ggtctggccg catcgctggg attggctgtt atcagcagtt 1273021 tcttacgggg ctttaaattt atcgcttgcc caagctgttt tggttccgct ggcgaatgaa 1273081 atgtcatcgg agaaagtgat aaaaaaaggc gctttaatcg gaggcacgat gctgacgatt 1273141 gtgctgtccg cgagttttct gtctttgtcg actcttccgg atgtattttt gtatgatata 1273201 ccgatggcgc aagtggttta tctctttgca cgatctgtcc atttgattta tttactcatt 1273261 attttcggag aagtgttcac atcagttatc ggtaatctat atggattaga aaaacaagtg 1273321 caaagctttc ttccagtgaa aagcaaatat atctttgcag ccattatgat cacggcttat 1273381 attacgagcc aaatagggta cggcaggctt atttcaacga tttatccctt gtttggctat 1273441 gtgagcctgg ccttcatagg cgctttgctt tgcaaaaaag ctcctcggcg gcgcagttta 1273501 taaatatata taatgaaacg aaccgtcact atagagcgat aattgatcta ggaaccgggg 1273561 actgactttt ttattgtcaa gaaaaacatc attatggtaa gatagcagaa gtgaaaaaat 1273621 tgaagaaaat ccgtgcgata tgcgggagag gttctagcta caccctctat aaaaaactaa 1273681 ggacgagctg tatccttgga tacggccttt tttatgtttt tctagagcac cttccgaaaa 1273741 aaggtgtttt tttgcgtgaa ttagctgtag cgatgtctct cgccggcgtt tttattgcgg 1273801 agaaggagag gaatcatgaa aaaagaaaaa gcaattgtcg tatttagcgg cggtcaagac 1273861 agcacaacat gcttactgtg ggccttaaaa gaattcgaag aagtcgaaac ggtgactttt 1273921 cattataatc agcgacattc gcaggaagtt gaagtggcaa aatccattgc ggaaaagctt 1273981 ggtgtgaaaa atcatttgct tgatatgtca cttttaaatc agcttgcacc gaatgccctg 1274041 actagaaatg atattgagat agaagtaaaa gacggcgaac tgccatccac attcgttcca 1274101 ggccgcaatt tggtattctt atcctttgcg tctatcctgg cttaccaaat tggcgcgcgc 1274161 cacattatta caggagtttg cgagacagac ttcagtggtt atcctgactg ccgtgacgaa 1274221 ttcgtgaaat cttgcaatgt cacggtaaat ctggcaatgg agaagccgtt tgtgatccac 1274281 acgcctctca tgtggctcaa taaggcggaa acgtggaagc ttgcagatga gcttggcgcg 1274341 ctggattttg tgaaaaacaa cacgctgaca tgctataacg gcatcatcgc agacggctgc 1274401 ggcgaatgtc cggcatgtca ccttcgttca aaaggttatg aagaatatat ggtgatgaaa 1274461 ggagagcgtg cataaattgt tatctcaaat ttatccgcag gcccagcatc cttattcgtt 1274521 tgaactgaat aaggacatgc atatctcagc cgctcatttt atccctcggg aaagtgcggg 1274581 agcgtgcagc agggttcacg ggcatacgta taccgtaaat ataaccgttg ccggcgacga 1274641 acttgacgat tcaggctttc ttgtcaattt cagcgtactc aaaaaactgg tgcacggaaa 1274701 ctatgatcac acgctattaa atgatcatga agatttttct caggacgacc ggtattcgct 1274761 gccgacaact gaagtcgtgg cgaaaacgat ttatgacaac gtacaggctt atttagacac 1274821 tttggagaat aagccgacct gtgtacaggt gtttgtccgt gaaacaccga caagctactg 1274881 tgtctaccgt ccgaaaaagg gtggtttgaa tggctaaagg aattcctgta ttagaaattt 1274941 tcggcccgac gattcaagga gaaggcatgg tgatcggaca gaaaacgatg ttcgtccgga 1275001 cagccggctg cgattattcc tgcagctggt gtgactccgc tttcacttgg gacgggtctg 1275061 ctaaaaaaga tattcgctgg atgacggcgg aggagatttt tgcggagctt aaggacattg 1275121 ggggagatgc gttttctcat gtgacgatct caggcggcaa cccggctctg ttaaaacagc 1275181 tggatgcttt tattgaactg ctgaaggaaa ataacatccg tgcagcgctt gaaactcaag 1275241 ggaccgttta tcaggattgg tttacgctga ttgatgacct gacaatttct ccaaaaccgc 1275301 caagctcaaa aatggtaacg aactttcaaa agcttgacca cattttaact tcacttcaag 1275361 agaatgatag acagcatgct gtcagcttga aggttgtcat ctttaatgat gaagatctgg 1275421 aatttgccaa aactgtgcac aagcggtatc cgggaatccc gttttattta caagtcggaa 1275481 atgatgacgt gcatacgaca gatgatcagt cactgattgc acatttgctt ggaaaatatg 1275541 aagcgcttgt tgataaggta gctgtcgatg cggagctgaa tctcgtcaga gtgctcccgc 1275601 agctgcacac cctgttatgg ggcaacaaac gcggagtata atagaaagga agatgaacat 1275661 gacgacaaga aaagaatcag aattagaagg tgtaacattg ctaggcaatc aaggtacaaa 1275721 ttatttgttc gaatatgcac cggacgtgct ggaatccttc cctaataaac atgtaaaccg 1275781 tgattacttt gtaaaattca attgcccgga attcacatct ttatgtccta aaacaggcca 1275841 gcctgacttt gcgacaatct acatcagcta cattcctgat gaaaaaatgg ttgaaagcaa 1275901 atcattaaag ctgtatctat tcagcttcag aaaccatggt gacttccacg aggactgcat 1275961 gaatatcatc atgaacgact tgattgaatt aatggacccg cgctacattg aagtatgggg 1276021 caaattcacg ccaagaggcg gaatttccat tgatccgtac acaaactacg gaaagcctgg 1276081 cacgaagtat gagaaaatgg ccgaataccg tatgatgaac catgatttgt atccggagac 1276141 aattgataat cgttaattat tccgttgtgt gatacggagt gtaaaaggaa gtggagtcac 1276201 agtaaaatcc gaacattcag cgttaatttt cagcggaaat gtgacctggt cacagcgaag 1276261 tgtgacccgc actaagctca ataaaagtgg gaaaagtcac acctgaaaat ggctctactc 1276321 atgggaattg tattaaaaag tgtgacctga ggtgcaacct gaactgtgac ttttatgcag 1276381 tgaaaaattg atagtacaga agcagattaa ggcgtacaat ttgtacgtct tttctttttt 1276441 atccgaaaga aaaaatgcct atctagagat cataggcatt aaatattatt atcaatatct 1276501 tcatttattt tttggctaag tttctgaacc ttctctttaa catttgaaac agctcttttt 1276561 tgaatttcat caattctcct gaatatagtc gatgacactt cttattagaa cttcactttc 1276621 aaaattgaat atctcattta tttctgactg ttcttcatct gttaggtgat ggtattgaag 1276681 ttgtttagca tttacttcag cagctacatc aatcctaact tagttgttct ggttgtacaa 1276741 tttcatattc accttctgca tactcttgct ccgcataata gcctccccat tgacagagct 1276801 cctgcaagat aggtttaaga gattctccaa gttcagtgga tgaatattca accttcggcg 1276861 gtacttgatt atacatcttt ctgctcacaa gtccactggc ttcaagctct ctaagtgttt 1276921 gaatcagcat tttctgagtt atatttggga taatgcgctt taattcactc gttctctttg 1276981 gtccattcat taaaaagtat aatacaaggc ctttccattt tccgccaata acttcctttg 1277041 tcacttcaaa cccacagcta aattttttca tgtctaaagc tctccattcc acatttatta 1277101 ctttttagtt actatatcac aaaaaagtgg gtacttccga taatgtgctt actgaaggat 1277161 actatatctt gtaagttgtt cttcaagtac ttaaaggtac tagacataaa ataaaattaa 1277221 ttctaaagga gtgttaagta tgggtaaatt tgaaggtaaa atagcgcttg taacgggtgg 1277281 aacaagtggg attggtcttg ctacagcaca aaaatttgta aacgaaggtg catatgttta 1277341 tattacggga cgtagacaaa acgaacttga taaagctgtt aaccaaattg gcaagaacgt 1277401 aaccggtgtt caaggtgata tttctaagct tgaagactta gacaaactat atgacattat 1277461 aaagcaggaa aaaggtaagt tggacattct ttttgctaat gcaggcatcg gcaacttcct 1277521 tccattaggt gaaattactg aagagcaggt tgatagaacg ttcgacatta acgttaaagg 1277581 aaccatcttt actgttcaaa aagcgttatc actattcccg gacaaagtag gttctattat 1277641 tgtaacgggc tctactgctg gatcaattgg caacccagcg tttagtgtat atggagcatc 1277701 taaagcagca ttaagagcac tagttcgcaa ctggattctt gacctaaaag gtactgaaat 1277761 ccgtgtaaat gtggttagtc caggaggtat tcttacacct gcctacgatg agctttttgg 1277821 tgatgcactt gaagaggtac tggaaaatag cagaaatact gttccagctg gaaaagttgg 1277881 gacacctgaa gaagtagcaa acgctgtatc tttccttgct tcagacgaaa gcagttactt 1277941 gacgggtgtt gaattgttcg tagatggcgg gctagcacag gtataatttc actgcgcaga 1278001 gattacaaat agtccccaaa aaaggttaat ggggatttac ttgaagaagt cgtataaaaa 1278061 agtcgttttc cttaaaggac agggaattcg acttttttat atttgaattt gattaacgtt 1278121 gtaaattcgc attttcctgg ggctactact aaatgacctg taaaaaagat tacactgtga 1278181 ataaatgtac ttaaagtaac gggggctctt gacttttaat aaaaaataat atccctgtcc 1278241 ttgtattcta atacttttaa aaatatttaa aggaatcctt atgtcctgaa taaccacata 1278301 ggaaaatatg ttgtaggttg ctttcttttt ttgtggggca tcccacacaa gctatctcgt 1278361 gatctcacac ctgaacgttt tttatagact agtaccgcga caagttatat tacatataca 1278421 taccaataaa gtagacatta aaaagtgaaa gagaggatgg aaatgtgtga aaattctttt 1278481 ccttgagagt catcccatgt ggctctatgg tttaccgaat gggtttaggg aagcaggaca 1278541 taccgtaatg atttccggtc ctgtaagtcg ggaaaatata actgaaatga tagacgaatt 1278601 taaaccagat ttaatagtat ctatgggatg gacaccagag cattcaaggg aaaagcaggc 1278661 ctggattcgc aacgctacta aaaaggtgaa tatccctctc gtttattggg caactgaaga 1278721 cccgctgcac actcaaaact ttactatccc gttaattaaa aagatgaaac cggattttgt 1278781 tttcacggtc acgccttctc tgtgtaaaac ttatgaaagc atggggatta aagcagctca 1278841 cttagacttt gcatttcacg aaagtataca tcaccagatt aaaccattag cgaaatacag 1278901 ttgtgatata gcagtggtgg ctaatgctta ccctaatttt cttgaagaac atccggaagt 1278961 gttccgttcg tcctctttaa aaacgcttat tcgtcctctt atacggaagg gtattcgcat 1279021 tgatttttgg gggagaaact gggaaaaaat gagtaaatat ataggaagag aaattccccg 1279081 caattggatc catggatacc ttgattatac tgaagcatat aaagtttaca gttcagcaaa 1279141 aatcattatc ggtttgcaaa actgtgaaag ccaacttaca caacgcacct atgagattct 1279201 tggttccggg gggtttttat tgacatcgga tacaccagca gttcgaggta aattcaaacc 1279261 tggccgcgat ctcatcgttt cttcctcccc aaaagaaaca ttggaaaagg ttaaatacta 1279321 tttaaatcat gatagcgaga gaaaaaagat tcagataaac ggtaaaaagg ctgtaaagaa 1279381 tgattcctat cggcatagag ccgagagaat gcttgaggtg ctaaaaagca gaggaatcat 1279441 aagaaactta ggggaaacca ttcattatgt agatgttctc aaagaaaaat acgtgatcca 1279501 tcatgttact cccggtgaaa cattatcaat aattgccagt aagtataatg tttccctgca 1279561 gcaactcatg gagcttaatc atttcaaatc agatcaaata tatgctggac aaatcattaa 1279621 gattagagag aaactgttta gaaatattaa taacaaatta ttctaaagga gagtaatatg 1279681 aatgaagggg aaaataccta aaataagaaa tcaagcgaat aaagtaaaaa gaacgcctcg 1279741 ttatatggaa tttcccgtga catacgaagt atatcatgtg gaatccggcg atacattatg 1279801 gacgattgcc aaatcctttg aaattccggt acaacaactt atgaatctta ataagctttc 1279861 ttcagataga atttatcctg gacaaattat aaagataaga gaaagataat ctttgaggtt 1279921 tcggaagcga atcaaattga aatgacaatc ctcatttttt tatttgtggg gaacttgata 1279981 tttttgggga tgaaggggtt atgagatgtt tcaaatgagc tattactatt ctggattagg 1280041 atgggacttt attcaacacg ttgatcaaac gaacggagta ttaaatgttg tgtctcctga 1280101 ttttttctat atcagaaaag atggatcatt acttctccgt tcagctaatc ccgatgtgat 1280161 taaagctctt catagaagaa aattaaaagt agttcctttt ctaagcaatc attgggatca 1280221 ggatttggga cgatttgcat taatgaaccg agttctttta gctaaacaaa tttctcatgc 1280281 aatagaagaa ctggatttgg atggagttaa tatcgatata gaaaacctta cagaaaaaga 1280341 tcggaatcta tttacagatt ttattagatt agtaaggaaa agtattccta gacataaaga 1280401 agtatcagtt gcagtggcgg caaatccttt tggctggacg aagggctggc acggatcata 1280461 tgattacgag tatttagcta aatatgcaga ttatcttatg gttatggcct atgatgaaag 1280521 ccgccttgct gggcctactg caagtgtagg atgggtggaa aagtccattc aatatgttct 1280581 gacccaaaaa atctctcctc aaaaactagt tttaggattg ccattctatg gccgctgctg 1280641 gatggaaggc caatctgcct ctcaagccat tcccctttac cttgttgtta gtaaaaaggc 1280701 atagcgggac aattattttt gacaccaaga gtcaatctcc aaaagctatt tttactgtca 1280761 atcacgataa aaaggggccg ttgccttcgg gaacatatac attatggttt gaaaatgaac 1280821 agtcactcag agcaaaaata aaactcgctc aaaaatataa tctgaaaggt cttggcagct 1280881 ggagtcttgg acaagaagat gcgtcagtct ggaatacagt gtttaaaaat atataatgat 1280941 ttatagttca gaacaaaatt cgaagataat tgcaatgaat ctctaaatgg acatactgaa 1281001 aggagtttat tacgagtgcg ggtaaaacag tgagggcatt ccataggccc ttctcccaaa 1281061 atgttctaca cgaggcatta cattgggctt gaaatacaca ttcaaactta tgttatagta 1281121 cgcattttac ggatgtgttg aatttattct gcttccatga tttaatcata cacatgctac 1281181 ttgatagcag ggttatcgca tttcattcag aattgttcag gatcgatatg gaagcgcacg 1281241 actaactaga actttaaaag catacactca tatacttcct gaatggatgc tggtttatct 1281301 aaaaaacatg atgagaattg attgtacgca tggtgaagca tgacttgttg ataatcgacc 1281361 atatggtttc tccttagaaa tgagggggtt tttacataaa aaagacgagc gaatccgggg 1281421 ggaattccac tcgccgcttt ctaatgaaaa gacgggatgc tggatggcag ctcgtctgtt 1281481 ttattataat ttaacgaacg tatgtttgta aaggtgtctt ttcgaatgaa ttggttcata 1281541 taaccgttaa gaacagattc attgtaaaca ttcgctaagg tatgctaaga tgcatggact 1281601 ataaaggagt gatatgaagt gaagacattg cggttaaaca atgtaacgtt agaaatggct 1281661 gcatatcaag aggagagcga gccgaagcga aaaattgcat ttaccttaaa cgttacgagt 1281721 gagacttacc atgatatcgc tgtcctgttg tatgaaaaaa cgtttaatgt cgaggttccg 1281781 gaacgcgatc ttgccttccg gggggaaatg acaaattatt caacatcatt gaccaacctg 1281841 tacgaaccag gggccgtcag cgagttctat atagaaataa cggaaataga caaaaacgcc 1281901 gattcatgat cggtgttttt tatgtaaaaa agctgccggc cggcagcttt tgagaaagcg 1281961 aatttcatat gtaaggtgtt aaattgtccg tcttgcagtt ttttgaataa atgtggaaat 1282021 aaggaggttt taataggagt ctctgatgat cttataattt ttatgattaa caactgtcaa 1282081 tgaatctaac tcaagatccc gatagttatc catgatcgtc acatcaacga taacagaatt 1282141 ctcatttact ttttcaacaa caccggttaa tccgttttta aattcaatga cattcccaac 1282201 cttagcgatt ttcacaagct tcctctcctt taaacataat aatgcctttt gaaagtattt 1282261 tgcagtattt tcattgagaa gtaaagcgat aaggagtttt atctccctta tgaattgttc 1282321 tgtcgctata aagatgatat attgattttc gtcaatagaa agaaaagggg ggaatttttg 1282381 ttgcgtcccg aagaaataac agaaatgatt gaacagctgc gcaccggcgc cataaacgaa 1282441 ctgagagtcc agaaagagca ttttcttgat ttcagggccg tgttatctaa acaagatgat 1282501 tttaaacatt tccgaggaat tgcccagcaa ggcggagatg ttatctttca atacttagaa 1282561 cagccaagaa gctgaaggtt tctcatacgt gagaagcctt tttatcatat atgacagaac 1282621 acaagccttt tattacagct gtctgtaaca ggtgtaaata aaatgtaaag taccaaagat 1282681 ggataaacat gttttaattt aacaatattt atagaatttc agactgtttt tttgccatta 1282741 agcagtgagt catcctcttt attccatcct gatacctcct tgggagagtt ggaaaatctt 1282801 tttccgtgaa aatgaatgga tctcttgtta aggttatgaa gtgttttttg gagcacttta 1282861 aggaggaaac tgtatgacaa cgaaattcac tgctctggct gtttttcttc tttgtttcat 1282921 gcctgcagcc aaaattgagc atacacaagc ttcactactg agcgcaaaga agacaaaaca 1282981 tgaagaagcg aaatggctta cacatataga tcgaaatacg aatgaatctt tcccttcact 1283041 gtctgctgat aaagacaaga aaataaaacc gattaagcta tcagcacaca ctgaaaagaa 1283101 agagaaagat aaaccggaca aaacaaatga tgagaaagaa acatatacac agtctgaaaa 1283161 agagttgctg tcccgtctcg ttcacgcaga ggccaaagga gaatcatata aaggcaaggt 1283221 cgctgtagca agcgttgtac tgaacaggac ggagaaaaaa ggttttcctg atacgataag 1283281 aggagttatt tatcagaaaa acgcctttga accggtcgca aacgggagca ttaaccaaaa 1283341 gcctgataaa gaatcgattg aagctgccga agaagcgctg tcctcaaaaa atagagaaac 1283401 agatgccata ttcttttata atccgaaaac agcgtcagat aattggattc gttcaagaaa 1283461 aatcgtagaa aaaatcggca gacacgtttt tgccgtctaa gcatagaaga gacaatttgt 1283521 ctcagctgtg ctttttttca tataaagagt aaaaataaaa taatttttga acttgtctca 1283581 tatgatgttg gtagtacaag agacaaggag agacatcatg aatcgatttg tgaaagggat 1283641 cattctttta tccattgccg cctttttcgc tgaatgcctt gaatttgtcg tcaatatgat 1283701 tttggcgcgg gagcttggcg agcatgggat ggggctttac atgagtattt tgcccacgat 1283761 ctttttaatt attgtcatcg cgagcctgga actgccgata tccatttcta aattcattgc 1283821 cgagtcaaat cctaagcttc atgaaagcat gctgaggcac gctttcagaa tgacagccat 1283881 ttttactgct ttttctactg ccgccgctag tattgcgctt ccgtttattc cggtatttga 1283941 tacataccac ccgtttatta aagggattgt catcggctta attcctgttg tcgcctttac 1284001 ttcaatcgcc aggggctact ttatgggtgt gcagaaaatg gggaagatcg caattgccaa 1284061 tgtgctgaaa aaaatcatcc agctcttgtg cttattcctc ttttttcaat ggtactcatt 1284121 tgaattggac atggctgtgc tgatttcctt gtttgttcta gtcgtgagtg atgtggtcgt 1284181 gcttgtttat ttatattcac aatttatcat ggcaaggcgg gcgttatccg gccagcagca 1284241 cattcatttg cgcggaaagg atgtaaggaa aagactgctt gctgtttcaa ttcctacaac 1284301 aggactgcgt atttttcatg cggttgtcaa tgcaattgaa ccctttttag taaaaggagc 1284361 tcttttggct gcgggcgttg ccgggacagc ggcgatcgat caatacggaa tgctggcagg 1284421 agtggctgtg acgatagggt cgttccctgc ttttattgcc cattcgttaa tggtcgtcat 1284481 gataccgagt atttcggaag cttatgcact ttctcagtat gacatcgtgt taaaaaggct 1284541 gaagcagtcg attttcatta cattaggtta cggtatacct gccgtctggg tcatgttcca 1284601 gtttgcggga cctctcacgc atttgttttt tcactctcct gaagcgcagt attacttgca 1284661 gctgttgtgg ccttactttc tctttcatct gtttgtcatg ccgctgcagg cgtgcttaat 1284721 cgggatgggt tttgtgaaag aggcttttta tcacaatgta tggagccata tcgttgcgct 1284781 aagtatgatg tatgtactgg gatcaatgga gaatctgcaa atgctcggga ttatccttgg 1284841 aatgaacact ggcatgattc ttttgacgag cctgcactat gccacgatct gcaaagcatt 1284901 gaaggtatct gtatttctta cgggagggac cagaacgccg cgaattgaag gatgataaag 1284961 gaacagcagg ggcaagctaa ttgaaaagca tgaaaggaag attccatgtt gacgaagcgc 1285021 ttgcttacta tatacattat gttattaggg ttgattgcat ggtttccagg tgcggcacaa 1285081 gctgaggaaa aacagcctgc tgttcccgct gtttttctta tgaaaacgat agaaggggag 1285141 gacatctcga ttccgaataa agggcaaaaa acaattctcc atttttggac gtcatggtgc 1285201 ccgccctgca aaaaggagct tccacagttt caatcgtttt atgatgccca tccatccgac 1285261 agtgtaaagc tggtaacggt gaatttagtg aattcggaac aaaatcagca agtcgttgaa 1285321 gactttatta aagcaaacaa gctgacgttt ccgattgtcc ttgactcaaa aggggaattg 1285381 atgaaggagt atcatatcat cacgatccca acatcatttt tgctgaatga aaagggagaa 1285441 attgaaaaaa caaaaattgg cccgatgaca gcggaacaac tgaaggaatg gacggaagaa 1285501 tagctgagag catagactct cagctttttt catatagaga agaagtgaat aaacattaat 1285561 gataattatt atcaaaaaga aattaaaata attataattg aaattctctt cgtgcgtgct 1285621 ataataaagg aagacatcaa gaaataactg acgataaagc tgccttttgg gcagcgattt 1285681 tgtttttata agagaaatga agatgattta cgttctcaat tagagaggag aattcgatat 1285741 gaatgaacaa gttatcgttc aacgcgaccc gcatgagcca ttgaaaacag acaagaggga 1285801 aaaaaactgg gcacagcacg cggagcttat tgcagcactt gtatcaggcg ctcttatttt 1285861 ggcaggctgg ctcttatccg gatatcaggt attatccata atacttttct tgctggcttt 1285921 tgtgatcggc ggatttgcta aagcgaagga aggaatcgaa gaaacactcg aatccaaaac 1285981 gctgaatgta gaacttttaa tgattttcgc tgccattggt tccgccttga tcggatactg 1286041 ggcagagggt gctattttaa tatttatttt ttccttaagc ggagctttag aaacatacac 1286101 gatgaataaa agcagcagag atttaacgtc tttaatgcag cttgagcctg aagaagcgac 1286161 attgatggtc aatggtgaaa ccaaaagagt tccggtttca gacttgcagg ccggtgatat 1286221 gattgtgatc aaacctggag aacgcgtagc ggcagacggt atcattgaat cgggctcgac 1286281 aagtcttgac gagtcggctt taacaggtga atcaatgcct gtagaaaaaa acacaggcga 1286341 cactgtattc acaggaacgg tgaatcgcaa tggctccttg acagtccgtg tcacgaaagc 1286401 aaatgaagat tcgttattca gaaaaattat caaactggtt gaatcagcgc aaaatagtgt 1286461 ttcacccgcg caggctttca tcgaacgatt tgaaaatgct tatgtgaaag gtgtgctaat 1286521 tgcggtggcg ctccttttat tcgtcccgca ctttgcgctg ggctggagct ggagtgaaac 1286581 cttctaccgc gcaatggtgt ttatggttgt cgcgtcacct tgtgcgcttg tcgcctctat 1286641 tatgccggcg gcgctgtccc tgatttcaaa tggcgcccgc aacggtatgc ttgtgaaagg 1286701 aagcgtcttt cttgaacagc tgggctcagt gcaaatgatc gcctttgata aaaccggaac 1286761 tgtaacaaaa ggccagcctg ccgtagagac gatcagaata gcagaaggat tcagtgaagc 1286821 ggaagttctt gaggctgtct atgccatcga aacgcaatca agccatccgc tcgcccaagc 1286881 cataacggcg tacgctgaaa gccgcggcgt gaatcagtcc ggctacatat ctatagaaga 1286941 aacctcaggg tttggcgtta tggcagaagt gtcgggtgcg aaatggaagg tcggtaaagc 1287001 aggttttatc ggcgaggaaa tggcagcaca atttatgaaa caaacagcat cagatgtcat 1287061 tcaaagcggt catacaattg tatttgtgaa aaaggatgat caaatagcag gctgtatcgc 1287121 actgaaggac caaatcaggc ctgaagcaaa agaggtcatg gaagaactga accgacttgg 1287181 gattaaaacg gccatgctga caggagatca cgaagacacg gctcaagcga ttgccaagga 1287241 agccggcatg acaactgtcg tggcagaatg cctgcctgac caaaaagtga atgaaatcaa 1287301 acggttaaaa gaagaattcg gaacgattgc aatggtgggt gacggaatca atgatgcgcc 1287361 ggcactcaaa gcagcggatg tcggcattgc gatgggcggc ggaacagatg tagcacttga 1287421 gaccgctgat atggtcctca tgaaaaacga tttgaaaaag ctcgtaaaca tgtgccgctt 1287481 gtctcggaaa atgaacagga tcatcaaaca aaatatcgtg ttttctctag ctgtaatctg 1287541 cctgctgatt tgtgcaaact ttttgcaggc gatggaattg ccatttggcg tgattggtca 1287601 tgagggcagc acgattttag tcatactaaa cggtttaaga ctcctaaaat aaaaccagca 1287661 gcctaatcag gctgctggct ttttatgtat caagctttcc cttcattttt gtctttatca 1287721 gatcttttca taactaggat gagagcgagg gtgcagcaaa ggaaacccgc tgcacagcct 1287781 atgatagagc tgtaataata aaagcccacc atcttcatcc cgataaaagg agcggaaatt 1287841 cccaaaaccg ttaagagcat aactgctttt cgtctgaaaa aattcatcag caaacggaac 1287901 aacccccctg cgattgaacg ttactgtcag tatacaggaa gaggagcagg aaataaaatg 1287961 cattagaaaa tgaaggcgtc gtgaaaggca aacaccggta aaacctgtta caatggaaga 1288021 cagaacaatg cattgcaaat ggcagggagg aacaagaagt gaatagaata caacgcgtct 1288081 cttcatggct gaaggaagcg gggcatactg ccgcatttat tcatacgaaa gaaaatgttt 1288141 tttacttaac cggtttttac acagagccgc atgaaagatt aatggggtta tttatttttc 1288201 aagaagagga gcctttcttt gtttgtccag gaatggaagc aggacaggcc cgcaacgcag 1288261 gctggaatca tgaaatcatt ggctatgcgg atcacgaaaa tccgtgggag ctgatagaga 1288321 aggctttgaa aaagcgaaat atcagcatac atatgcttgc ggtagaaaag gattcaatct 1288381 cgctgtcacg tgcagaacag ctgaagcatg cgacgggcgg ggctcaattt gtttcagcag 1288441 aagaaacact caatcaattt cgcctgatta aagatgacaa tgagattcgt ttgctgaaag 1288501 aggcggcaaa gcttgcagat tacggtgttg aagtcggcac agccgctttg cgtgaaggca 1288561 tcagtgaagt ggaagtgctc gctcaaattg agtatgagct gaagaaaaaa ggaattcagg 1288621 gcatgtcttt ctctacaatg gttttattcg gagaaaaatc tggccagcct catggaaatc 1288681 ctggtacagc cacgttgaag aaaggtgatt ttgttttatt tgatctcggt gttattcttg 1288741 atggctattg ctctgatatt acaagaacgt ttgcatacaa aaccatcaat ccgaagcagg 1288801 aggccattta cgagactgtg cttcaagcgg aaaaagccgc gattgaggca agcaaacccg 1288861 gtgtgagaat cggagatctg gatttaactg cccgcggaat cattgaaaaa gcgggatatg 1288921 gtgattattt tcctcaccgg cttgggcatg gactcggaat ttcagtccat gagtatccat 1288981 caatgagcca ggccaacgat acactgctgc aggaaggcat ggtctacacg atcgaaccgg 1289041 ggatttatgt gccagagatc ggcggcgtac gcattgagga tgacgttcac gtaacaaagg 1289101 acggagcagt tgctctgacc caatatccaa aggatttgat catactgtaa tagaaataaa 1289161 aaaggacttt gttctcgaca tcgtcctttt ttatctgcat taaataaaaa aatcatcaaa 1289221 tgttcgaaag ggtttaattt catgtttttg gttgagaggt tttacagcaa gacagctgcc 1289281 accgagaaca gtgagacata acccaattaa aatgaagaaa cccatgtgat cttctccttt 1289341 cagctaaaaa cacaaaaaga tatctggtac gtccatatca tattgtatga aacgcattcc 1289401 agatcaaggg gatttagaaa gaagggaatc tatggctaat attaaagaca ttgcagagaa 1289461 agccggtgtc tctgttacaa cggtttcccg agtcataaac aatcatccat acgtcagtga 1289521 agacaaacga aaaagagtgt ttgaggcaat ggaatcattg gagtacacga gaaatattca 1289581 cgctgtacat ttgtcgaaag gattttcaaa catgattggt gttgtcttgc cgacggttaa 1289641 tctgccatat tttgcagagc tgattgcagg aatagccgac gcagccgcgg aatccggggt 1289701 tcacctctct ttattccaaa caaactatga agtacaaaaa gaaatctttg cgctgtccca 1289761 attaaagcag cgccaggttg acggcctgat tttttgctca aaggcgcttg ctgatgagaa 1289821 actcatggaa tgggagggcc cgattttgct ttgccagaat tcagataatg cccgcttccc 1289881 aaccatcagc attcctcacc aagaagcatt tcggaacggc ttggactatt taattgccaa 1289941 agggcacaaa aaaatagcca tctgtttggc aagaaaaaaa ggcatgaaca gccattttcg 1290001 aatcaaagcc tacaaagagg cattggaaga gatcggcgag gcatttcgtg aagactgggt 1290061 aattgagaaa gcgattacaa tcaatgatgg gaaggcgctt tttcataaat ggaatacgtg 1290121 gaaggaaaag ccgacggcta tttttgttgc caatgaccaa gtctcagcag ggctttttct 1290181 tgaagcaaag aaccagcggg tgtcagtacc ggatgagctt gcaatcttaa gcgttgataa 1290241 ccacgaaatc agccaagcgc ttggaatcac aacgatcgat attcagacaa gggaaatggg 1290301 aaagcaggca tttgccatat tggaaaaaag aattcaagga cagccgattg aaaggaaagt 1290361 tctggattac cgtctcatcg aaagatcgac tgtttagtga atgcattgaa aaaaggtttg 1290421 acgtgcattc tgttcgttat gtacgatatg aggtattgaa tgacaaagga gctgaggatc 1290481 gtgaatgggt ccttcacagt gaaaaaggta ctgaataata acgtattaat tgcttctcat 1290541 cataaataca gcgaagtcgt tttaatcgga aaaggtattg gtttcggaaa aaaacaagat 1290601 gatgtcattg aagataaagg ctacgataaa atgttcattt taaaagacga gaaggaacaa 1290661 aagcagttta aaaagctcct tgactatgtt gatgaaaagc tcgttgatat ttcaaacgat 1290721 gtcatctatc acataagcaa taggacgaat cactcattaa atgaacatat tcacattgcg 1290781 ttgacagacc atatcgcatt tgcgatcaaa aggcagcagc agggatttga tatgaaaaat 1290841 ccatttctaa tggagactca gtcactatat cctgaggagt accaaattgc caaagaagtc 1290901 atagatatga tcaatgaaaa agcgggactc tgccttccgg aaggggagat tggttttatc 1290961 gctctgcata tccattcagc gttgacaaac cgtccgctgt ccgaggtcaa tcagcactct 1291021 cagctcatgg cgcagcttgt cgaggtgatt gaagactcat ttcaaatgaa agtaaataag 1291081 gaaagtgtca actatttgcg gctgatcagg catatcagat ttacaataga aagaattaaa 1291141 aaagaagaac cgactaaaga accagaaaaa ttaatgttgt tattgaaaaa tgaatatccg 1291201 ctatgctaca atacagcttg gaaattgatt aaaatcttgc agcaaacatt gaagaaacca 1291261 gttcatgagg cggaagcggt ttatctgacg cttcatctgt accgattaac caataaaatt 1291321 tcataaattc agtttatcct tataacgtgt tactgattcg atcaggcatg agtgattgag 1291381 ggaaaaaaac gggaagttca ttctcgttct tttgcgcacc caattttgct catgcctttt 1291441 tgttgtgtaa aagggcaaat gtaaacggtt aaactggaag acttacgcct gtgaattcgt 1291501 tgtcatgatt tttagctgta aggtcagact agtaaaaaga ggaggtcaat tcttatgttt 1291561 aaagcattat tcggcgttct tcaaaaaatt gggcgtgcgc ttatgcttcc agttgcgatc 1291621 cttccggctg cgggtatttt gcttgcgatc gggaatgcga tgcaaaataa ggacatgatt 1291681 caggtcctgc atttcttgag caatgacaat gttcagcttg tagcaggtgt gatggaaagt 1291741 gctgggcaga ttgttttcga taaccttccg cttcttttcg cagtaggtgt agccatcggg 1291801 cttgccaatg gtgatggagt tgcagggatt gcagcaatta tcggttatct tgtaatgaat 1291861 gtatccatga gtgcggttct tcttgcaaac ggaaccattc cttcggattc agttgaaaga 1291921 gccaagttct ttacggaaaa ccatcctgca tatgtaaaca tgcttggtat acctaccttg 1291981 gcgacagggg tgttcggcgg tattatcgtc ggtgtgttag ctgcattatt gtttaacaga 1292041 ttttacacaa ttgaactgcc gcaatacctt ggtttctttg cgggtaaacg tttcgttcca 1292101 attgttacgt caatttctgc actgattctg ggtcttatta tgttagtgat ctggcctcca 1292161 atccagcatg gattgaatgc cttttcaaca ggattagtgg aagcgaatcc aacccttgct 1292221 gcatttatct tcggggtgat tgaacgttcg cttatcccat tcggattgca ccatattttc 1292281 tattcaccgt tctggtatga attcttcagc tataagagtg cagcaggaga aatcatccgc 1292341 ggggatcagc gtatctttat ggcgcagatt aaagacggcg tacagttaac ggcaggtacg 1292401 ttcatgacag gtaaatatcc atttatgatg ttcggtctgc ctgctgcggc gcttgccatt 1292461 tatcatgaag caaaaccgca aaacaaaaaa ctcgttgcag gtattatggg ttcagcggcc 1292521 ttgacatctt tcttaacggg gatcacagag ccattggaat tttctttctt attcgttgct 1292581 ccagtcctgt ttgcgattca ctgtttgttt gcgggacttt cattcatggt catgcagctg 1292641 ttgaatgtta agattggtat gacattctcc ggcggtttaa ttgactactt cctattcggt 1292701 attttaccaa accggacggc atggtggctt gtcatccctg tcggcttagg gttagcggtc 1292761 atttactact ttggattccg atttgccatc cgcaaattta atctgaaaac acctggacgc 1292821 gaggatgctg cggaagaaac agcagcacct gggaaaacag gtgaagcagg agatcttcct 1292881 tatgagattc tgcaggcaat gggtgaccag gaaaacatca aacaccttga tgcttgtatc 1292941 actcgtctgc gtgtgactgt aaacgatcag aaaaaggttg ataaagaccg tctgaaacag 1293001 cttggcgctt ccggagtgct ggaagtcggc aacaacattc aggctatttt cggaccgcgt 1293061 tctgacgggt taaaaacaca aatgcaagac attattgcgg gacgcaagcc tagacctgag 1293121 ccgaaaacat ctgctcaaga ggaagtaggc cagcaggttg aggaagtgat tgcagaaccg 1293181 ctgcaaaatg aaatcggcga ggaagttttc gtttctccga ttaccgggga aattcaccca 1293241 attacggatg ttcctgacca agtcttctca gggaaaatga tgggtgacgg ttttgcgatt 1293301 ctcccttctg aaggaattgt cgtatcaccg gttcgcggaa aaattctcaa tgtgttcccg 1293361 acaaaacatg cgatcggcct gcaatccgac ggcggaagag aaattttaat ccactttggt 1293421 attgataccg tcagcctgaa gggcgaagga tttacgtctt tcgtatcaga aggagaccgc 1293481 gttgagcctg gacaaaaact tcttgaagtt gatctggatg cagtcaaacc gaatgtacca 1293541 tctctcatga caccgattgt atttacaaac cttgctgaag gagaaacagt cagcattaaa 1293601 gcaagcggtt cagtcaacag agaacaagaa gatattgtga agattgaaaa ataagggtgt 1293661 tagtacgccg tgcttgtcag atgacaagta cggttgtatg atataatatt gtgaagtaat 1293721 aaagctttaa gttaaaagga gaatgataaa aatggcacaa aaaacattta aagtaactgc 1293781 agattctgga atccatgctc gtcctgcgac agttcttgta caaactgcta gcaaatacga 1293841 cgctgacgtt aatttagaat ataacggcaa aacagttaac cttaaatcta ttatgggtgt 1293901 tatgtcttta ggtatcgcta aaggcgctga gatcacaatc tctgcttccg gagctgacga 1293961 aaacgatgct cttaacgctt tagaagaaac aatgaaaagc gaaggactcg gcgagtaatg 1294021 caagaattaa aagggattgg tgcttcagcc ggcatcgcga ttgcaaaagc gtaccggctt 1294081 gaagagccag atttaacggt tgaaaagaaa aacatctctg attctgaagc ggaagtaagc 1294141 cgttttgatg aagcgattgc acgttcaaaa gaagagctcg aaaaaatcaa agagcacgct 1294201 ttgaaagaac tgggtcagga taaagctgat attttttctg ctcacctttt agttctcagt 1294261 gaccctgagc ttctgaaccc tgtgaaagaa aaaatcagca ctgattcagt gaacgctgaa 1294321 ttcgctttaa aagaaacgtc ttctatgttc gttactatgt ttgaatctat ggacaacgaa 1294381 tatatgaaag agcgtgcggc agatatccgc gatgtaacaa aacgcgtaac cggccacctg 1294441 cttggcgtcg aaattccaaa cccaagcatg atctcagaag aggttattat tgtagctgaa 1294501 gacttaacac cgtctgacac agctcaatta aaccgtgagt tcgtaaaagg attcactact 1294561 gatatcggcg gacgcacatc tcactctgcc atcatggcac gttctcttga gattccagca 1294621 gttgttggaa cgaaagctgc tacaggcacg atccaaaacg gcgtgactgt tatcgttgac 1294681 ggtatcaatg gcgatgtcat tattgaccca tctgcggaaa ctgtaaaaga gtatgaagaa 1294741 aaacataatg cttatttggc tcaaaaagct gagtgggcga agcttgtcaa tgaaccgact 1294801 gtctcaaaag acggacatca tgtagagctt gcagcgaaca tcggtactcc tgatgatgta 1294861 aaaggtgttc ttgaaaacgg cggagaagca gttggccttt accgtacaga attcctttac 1294921 atgggaagag atcagctgcc tacagaagat gagcagtttg atgcttacaa aacggttctt 1294981 gagcgtatgg aaggaaaatc agtcgtcgtg cggacacttg atatcggcgg agacaaagag 1295041 cttccttacc tgcagcttcc taaagaaatg aacccgttcc tgggatatag agcgattcgt 1295101 ctttgccttg aagagcaaga aatcttcaga acacagcttc gcgcgctgct tcgtgcaagt 1295161 acatacggaa acttgaaaat catgttccct atgattgcga cagttaacga attcaaagaa 1295221 gcaaaagcga tccttcttga agagaaagaa aagctcgtaa aagcgggaca ggctgtatct 1295281 gacgatattg aagtcggaat gatggttgag attccgtcaa ctgcagtcat cgctgatcag 1295341 tttgctaaag aggttgattt cttcagtatc ggaacaaacg atttgattca atacacaatg 1295401 gcagctgacc gtatgaatga acgtgtatct tacctgtatc agccatacaa cccggcaatc 1295461 cttcgcttaa ttacactggt aattgaagca gcacacaaag aaggaaaatg ggttggcatg 1295521 tgcggagaaa tggcaggaga cgagattgcg attccgatcc ttctcggctt aggcttagat 1295581 gagttctcaa tgagcgcaac gtctatcctt ccggcaagaa cacaaatcag caaattgtct 1295641 aaacaagaag ctgagtcatt caaagagaaa atcttatcta tgagcacgac agaagaagtt 1295701 gtcgcgttcg taaaagaaac attcaagtaa tgtacaaaaa ccagacggcc tccggcctgt 1295761 ctggtttttt tcataagtaa gggtatagaa ggacacaata acatggctag gagggatagt 1295821 atgtcaaacc aatttaacgc aggagatact gtttatgtga tctacagaaa tccgcacgcc 1295881 gccaatgtag cccacataaa ggaagccgaa attgtgcacc atccatacca tgaaggcgag 1295941 ctttccctgt ttatttatga aacctatcat ccattcgcag aggacgatgc tgtgtttgca 1296001 agctatgaag aagctaaatc gctttacaaa gaactgtttg atattgatcc gtatgagtaa 1296061 caaggaaatc attacaactc atatcctttc cgcctagtga gaaaagtaac gttagtaaag 1296121 gaaaaggatg tggcatcatg cagaacccat ttgttccgca gcttgtgtat atagaaccga 1296181 gggcgctgga atatccgctg ggccaagaat tacaagataa atttgagaat atgggtattg 1296241 aaatcagaga aacgacatcc cacaatcagg tgcgtaatat ccctgggaaa aatcatcttc 1296301 agcaatatcg caatgcgaaa tcaactttag ttatcggtgt ccggaaaaca ttaaagtttg 1296361 attcatccaa accctcggcc gaatatgcca ttccgtttgc aacaggctgc atggggcatt 1296421 gtcattactg ctacctgcaa acaaccatgg gatcaaagcc gtatatcaga acttatgtaa 1296481 acgtcgaaga gattttagat caggcagata agtatatgaa ggagcgcgca ccagagttca 1296541 caaggttcga agcatcatgt acgtcagaca ttgtaggaat tgatcatctg acacacacgc 1296601 tgaagcgcgc cattgaacat tttggccaaa gtgatctcgg aaagctccga tttgtaacga 1296661 aatttcatca tgtcgatcac ctattagacg caaagcataa cgggaaaacg agattcagat 1296721 tcagtattaa tgccgactat gtgattaaaa actttgagcc gggaacttca cctcttgata 1296781 agcggataga agcggcagta aaagttgcaa aagcaggcta cccgctaggc tttattgttg 1296841 ctccgattta tattcatgaa ggctgggaag aaggatacag acatctgttt gaaaagctag 1296901 atgctgcttt gccgcaggac gttagacatg acattacgtt tgaattaatt caacaccgtt 1296961 ttacaaaacc ggccaaacga gtgatagaga aaaattatcc gaagacgaag ctcgaattag 1297021 atgaagaaaa gcgccgttat aaatggggcc gttacgggat cggaaaatat atttatcaga 1297081 aagatgaaga gcatgcactt cgagaggcac ttgaatccta tattgatacc tttttcccta 1297141 acgcaaaaat tgaatatttc acttaaacgg gctgttgtga tcaacagctc gcttttttat 1297201 aaaaaacatt tttccattcc atcaaaacgc cgtaattcaa tgattcttta tcctccaaat 1297261 aattgctgac tacacgaata ggtgaacgcc cgcaacggag gagaaaggac agcacagggt 1297321 cgtttttcct gccttccatc acatcttcaa cgtactgaac agcgctgatc tcgtgtgcgt 1297381 atttataata caaaggaatg cggccgccgc cgagaaggcg ttccagtctt ttatcaacag 1297441 tcagctcata catcgtattc atcagccatt ttccgattcc aagctttcga taatgaggag 1297501 aaacagaaat atccactaca tataaagtat ttccatgagg ttcatgattt ttaatcgatc 1297561 cgttgtcagt tgcttgtgcc catgtatgat caggagaatc aggctcaaat tgtacaataa 1297621 gagcagtcat ggaaccgata attctgccat tgatgagcgc gcataaagcg ccttccggaa 1297681 aggttttgat atggctggca agctggtcct ctgaccacag caattcctgg ggaaacggag 1297741 gagggaaaca ttcttcttga agagaaatca gcctctcgat gtcagtctca gtgtagtttc 1297801 taatggtcag agcctcaaat tttctgccgt catgcacata catttgtttt agtatgatca 1297861 tcactctcct tatgttgttt cattataacg aagattgaat tttcagtaaa tatattccga 1297921 ttttcttata atttattttt tgattattca tttttcaaac gaaagggccg atatagaaat 1297981 taggagggga ttggtttgtt taaaaaactt cacatgaaga ttgctgtttt tgtttcgatt 1298041 atgttaatca tcacagttgt tctcttaatg ctgtcttctt atttgacgct aaaaccgatg 1298101 attacagagg atgggaaaaa tacaactcaa aacgtgacgc agtcacttga acaaaatatt 1298161 gaattgcaat taaagagtta tgccatttcg ttatcaagat tggctaatgg ggaattaacg 1298221 catacatttg taacgaaacc aagtaaagaa gcttctcggc tgtttcacga tgacattaag 1298281 caaatcaaag acaacgatga ttatgttgcg atggcttaca taggcaccgc aaaaaaagaa 1298341 atgtttacat atccaaaagc ggatttcgct gaggattacg atccaacatc aagaccatgg 1298401 tataagcttg cagctgaaac cccggatcaa gttgtttgga cggaacctta taaagatgtc 1298461 gtgacaggag acatgattgt tactgcatcg aaagcgatct tagacaggca aaaagtgata 1298521 ggggttgcca gctatgactt gaaactctct gctatccaga gtatggtcaa taaacaaaag 1298581 gtgccttaca aaggatttgc ctttttagct gatgcgagcg gcaatctttt agcccatccg 1298641 tcaaatcaag gaaaaaatat atcaaaggat caaacactgc aaaccatcgc atccgagaaa 1298701 aaagggatac aagatgtgaa tgggaaaatg gttgtgtacc aaacgattgg cgagacaggc 1298761 tggaaggtcg gaacgcaatt tgataccgat caattaatgt ggatttcaga taaaatgaat 1298821 cgggccaatc tttggatatc attgattgcg cttatcataa caattattct cagctacttc 1298881 ctggccaaaa cgataaccgg tccgatacag cagctgatcg taaaaacgaa agctgtttcc 1298941 gcaggcgatt taacagtgcg cgcggaatca aaatctaagg atgaagtcgg tattttaaca 1299001 agagatttca atctgatggt tgaaaatatg aaggaaatgg ttgagcaagt gagactctct 1299061 tcagggaaag tatctgacac ctctgaacaa ctaacggctg tggctgccga aactaatgaa 1299121 acaagcggac aaattgcaaa agcgattgaa gaagtagccg caggggcatc ggaacaggct 1299181 tctgaagttg aaaccattaa tgaaaaatcg gaaagcctgt caacgaaaat caggcaaatc 1299241 gctgaggagg caggcggaat taaagaacgc tcaaaatcgt ccgaggatgc aagctataaa 1299301 ggacttgacg cgctcggcca gctgctgatg aaatcaaacg aagccaatat ggaaacgaaa 1299361 aaggttgaaa cgatgctgct ggatttggaa aatcaaacta agaatattga agaagtcgtt 1299421 acagcgattt caaacatatc tgatcaaacc aacttgcttg ccttaaatgc cagtattgag 1299481 gcagccagag ccggagaaag cgggcgcggt tttgccgtcg tagccgatga agtgcggaag 1299541 ttagctgagc aatcagccct ttctacaaag catatcagcg agactgtgaa gcttatccag 1299601 cttgagacaa aagaggcctc tcacgcgatg gttgaggcaa gcagaatgaa tgatgaacaa 1299661 aacagtgcaa ttcacgaaac tggagaggta ttaaatacga taactgcaga aatgcagtca 1299721 ctggtacaag gtattgatca catttacgcg gaaattcaaa gaatgagtga agaacagctt 1299781 gcgatttctg aagccattca aagcatttca gccatatcac aggaatcagc tgccgcagca 1299841 gaggaagtga acgcatcaac cgatgaacag cttgtcaccc ttgataaagt caaacactca 1299901 acggaaacac taaaacatgc aagccaagag cttatgaaca caattgcaaa attcacattg 1299961 taatccaatt acatccccaa acatcatttg ttttggggat tttttatttt ataagatgaa 1300021 tagatatggt agtctagaaa atgaaggaaa aatgataaat tttaactaaa atctaaacga 1300081 aacatctggg aggaatgacc ttgaaaaaaa caattggttt tatcggtctt ggagtaatgg 1300141 gaaaaagcat ggcatcacat attctcaatg acggccatcc tgtattggtg tacacccgga 1300201 caaaagaaaa agcagaaagc atacttcaaa aaggcgcgat ctggaaagat acggtcaaag 1300261 atctttcgaa agaagcggat gttatcatca caatggtcgg ctatcccagt gatgttgaag 1300321 aagtgtattt cggaagcaat ggaattattg aaaacgcaaa agaaggtgca tatcttattg 1300381 atatgacgac atctaagcct tcgcttgcga agaagattgc tgaagcggcc aaagaaaaag 1300441 cattgttcgc tttagacgct cctgtttccg gtggagacat cggtgcacaa aacggaacac 1300501 tcgcgattat ggtcggtgga gaaaaagaag cttttgaagc ctgcatgccg attttctctt 1300561 taatgggaga gaatattcag tatcaaggac cggctggaag cggacagcat accaagatgt 1300621 gcaatcagat tgcaattgca gccggtatga tcggtgttgc tgaagcgatg gcttatgccc 1300681 aaaaatcagg cctagagccg gaaaatgttc tgaaaagcat cacaacgggc gcagccggaa 1300741 gctggtcatt gtcaaatctt gctccccgta tgctgcaagg caactttgaa ccgggatttt 1300801 atgtgaagca ttttattaag gatatgggaa ttgcactaga ggaagcagaa ttaatggggg 1300861 aagaaatgcc aggcttgtcg ctcgcaaaat ctttatatga caagctagct gctcaaggtg 1300921 aagaaaacag cggaacacag agtatatata agctttgggt gaaataaaaa aagattgcct 1300981 gtacgaaaca ggcaatcttt ttttattatt ttccgatgaa ttgttgtgtc cagatgcttc 1301041 cagactcaac gtaaccaaca ccgatgtgag taaagttagg gtttagaatg ttttttctgt 1301101 gtccttcact gttcatccaa gcttttacta cttcttctgg tgtcttttgg cccttcgcaa 1301161 tgttttcacc tgctgttttg tagctgattc cgaaagattt catcatatca aacggtgagc 1301221 cgtatgttgg gctttggtga tcaaagtagt ttttgtcttt catatcctga gattttgcgc 1301281 gtgcagattt gcttaacgtt tcatcaattt gaagcggttt taagccttgt ttttgtcttt 1301341 ctgcatttgt aagttcaaca acttttttct catatgcact tacagatgaa ggtgcagacg 1301401 ttgttgtgtt tgttttttca gcagttgcgg gtgctttaga agcagtgttt tgatcagcag 1301461 ctgctttttc agtagtcttt tgtgcaggtt ttgccgtttc tgtcttttga acatcctgaa 1301521 ctttcacgtt agattgcttc gcatgttttt gaagaagctg cttcatctct ttttcgtttg 1301581 cagcgtttaa cgttttgata tttgtgttaa tatgcagttt tttcactgca tcgttaagtg 1301641 acatgttttg tactgtgttc cccgttttta ctgtaaccac aggctggcag gagagttctt 1301701 tcgctgatgc ttgctgtacg cccccgaatg tgaataatcc aaccgcagcg gcagcagata 1301761 aaataaatgc tttcttcatt agttcgtaac ctcctagagt tgtttgtttc tacagaaaaa 1301821 tcataacata gcttttttgt cataaagatt ccagcacttt cctttgacaa atagagattg 1301881 tcattttcgt aaagtaaatc cgttgaatca ctaagaataa gggaatcagc ggtatatatg 1301941 attttatcgt accgttacat agcttccttt tttttgaacc gttagttata ttttaatgtg 1302001 tttttatatt gacagctttt tttactcctt ttcgctgtaa caactattac aaaggtgtta 1302061 caattaatct cagtatatgt aaatatattg aatgatttga gaggggtaac cagaagtgac 1302121 tgaaatagga cgtgaaccaa agaaaaagag caaaggaaac agagcaatca gaatgaacct 1302181 ttttttccta gctgtctttg ttctattcac tgcattaatt tttaagctcg gggttgttca 1302241 aattgttgaa ggcgaacagc atgaagaaga cgctgagaaa tcaaatgcaa aaacagctta 1302301 ctatcctgcg cctcgcggga agatgtacga cagaaaccag aaagttgctg tcgacaacca 1302361 gagcgttcca gaaattgtgt atgtatcaac atctagcaca aaaacagaag ataaaatcaa 1302421 aacagcgaag cggcttgctt ctttcattca tattgatacc gaatttttga aggaaaggga 1302481 tcttcgtgat tactggatcg cagctcatcc gaaaaaagcc gccgctctgc ttaaggaatc 1302541 agaaagcaat ctgaaaggag accaggctta caagcttcaa atagagcgtg ttccggatca 1302601 agaattaaag gctattcagc aagatgacga agaaatggaa actgctgcga tatatacaag 1302661 gttttcaagc ggaaatgctt acgaacctca aatcgtaaag gcaatgaatc caaataagag 1302721 caatagcaat ggaaaaaacg gagcgctgct tgatgagaag aaaaactcct cgcaaagacc 1302781 aaaaaatgac ttaacatatg atgaaatttc cattgtttct gagcatttag aagaacttcc 1302841 gggaatcgat atcgtaaacg attggacacg aaaatatcct tatgacaaaa ccctttattc 1302901 tgttttcggg ggcgtcacga cacctgatca gggcctgctg agcgaccgga aagatttcta 1302961 cttaacaaga ggctatgcga ataatgacag ggtgggaaaa agttatttag agtatcaata 1303021 tgaagaatat ttaaattcgc ataaagaaaa agtggaatac gtagaagata ataaaggaaa 1303081 tgtcgtcagc caaaaaacca ttgataaggg cagcagggga tacgatcttc agctttcttt 1303141 tgacatggag cttcaggcaa aggtagaaaa gatcattgaa gaagaagtaa gaaacagccg 1303201 tgcacgcgga aattacatgc ttgacagagc ctttgccgta atgatggacc cgaataacgg 1303261 cgatatttta tcaatggcag ggaaaaagat agatttaaaa accaacaaaa ttgaagatta 1303321 tgcgataggg gcatttacca cccaatatga aatgggatca gcagtaaagg gggccaccgt 1303381 gctagccggc tatcaggacg ggatcccgca ttataaatat tatatcgatg ctccaatgct 1303441 tttaggaacg aatcttataa aaaaatctta tactaatatg ggaaccatca atgaattaac 1303501 cgcattgcaa aaaagttcaa acgtatatat gttcaatgtt gccatgcata ttgcaggcgt 1303561 aacatacaag ccgcatggat ctctcccggc tgatcagaac gatctactga aaatgagaaa 1303621 ctattacagc cagtttggtc tgggagtaaa gacaggtatt gatctcccgc aggaatcagc 1303681 cggaatgcaa accacaccta aaactgtagg aggattaatt ttagacttag caattggcca 1303741 atacgataca tacacaccgc ttcaaatggc tcaatacatc tcagtaatcg ccaatggtgg 1303801 ctatcgtgtt cagcctagaa tcgtcacaag tattcataag ccaggaaaaa aagaccagct 1303861 gggtaaggcg attgaacata ggaaacctaa agtactcaat aagattaata attcagagag 1303921 cgatttgaaa caagtacaaa caggcatgaa attagtcact tcttcaggga cagcaaaaaa 1303981 tacgtttaca gaagatgtat cagggaaaac gggaacagcg gaaacatttt actacggcac 1304041 gaatcgcaac tggtggggga aaaaaacata caatctgact tttgtcggct attacccgtc 1304101 gaaaaaacca aaagtggcct ttagtgttgt tgttccatca gtagatgatg atgataagat 1304161 caataaaatt attgccaaaa gagctatcca cgcctacgca gagctcgaaa aaaaacacag 1304221 taaaaaataa aaaacagggt gcacaactaa aagattgtgt gccctttctt ttattcaaaa 1304281 attgacgttc accataagaa tagaaggaga atactcattt tctagcgaat catactaggt 1304341 aaaagtcaat ctgtatatgt cgaaacacga tgatcatgca aaggagggat tctgtggaac 1304401 aggatacgca gcatgttaaa ccacttcaaa caaaaaccga tattcatgca gtcttggcct 1304461 ctaatggacg catcatttat atatctgcca actccaaact gcatttgggc tatctccaag 1304521 gagagatgat cggatcattc ctcaaaacgt ttctgcatga ggaagaccaa tttttggttg 1304581 aaagctattt ttataatgaa catcatctga tgccgtgcac ctttcgtttt attaaaaaag 1304641 atcatacgat tgtgtgggtg gaggctgcgg tagaaattgt tacgacaaga gctgagcgga 1304701 cagaacggga aatcattttg aaaatgaagg ttcttgaaga agaaacaggc catcaatccc 1304761 taaactgcga aaaacatgaa atcgaacctg caagcccgga atcgactaca tatataacgg 1304821 atgattatga acggttggtt gaaaatctcc cgagtccgct atgcatcagt gtcaaaggca 1304881 agatcgtcta tgtaaacagc gcgatgcttt caatgctggg agccaaaagc aaggatgcta 1304941 ttattggtaa atcgtcctat gaatttattg aagaagaata tcatgatatc gtgaaaaaca 1305001 ggattatacg aatgcaaaaa ggaatggaag tcggaatgat tgaacagacg tggaaaaggc 1305061 ttgatggcac acctgttcat ttagaagtga aagcatcccc gaccgtctac aaaaaccagc 1305121 aggctgagct gctgctgctg atcgatatct cttcaaggaa aaaattccaa accatcctgc 1305181 aaaaaagccg tgaacgatat cagctgctga ttcaaaattc cattgatacc attgcggtga 1305241 ttcacaatgg aaaatgggta tttatgaatg aatcgggaat ttccctgttt gaagcggcta 1305301 catatgagga tttaattggc aaaaacatat acgatcagct gcatccttgc gatcacgagg 1305361 atgtaaaaga gagaatccaa aacattgccg agcaaaaaac agaatctgaa attgtcaagc 1305421 aatcctggtt cacctttcag aacagggtca tctatacgga gatggtctgc attccgacga 1305481 ccttttttgg tgaagcggcc gtccaggtca ttcttcggga catctcagag agaaaacaaa 1305541 cagaagaatt gatgctgaaa tcggaaaaat tatcaatcgc agggcagctc gcggcgggaa 1305601 tcgcccatga gatccgcaac cctcttacag cgatcaaagg atttttacag ctgatgaaac 1305661 cgacaatgga aggcaacgaa cattactttg atattgtgtt ttctgaactc agccgtatcg 1305721 aattaatact cagtgaactg ctcatgctgg cgaaacctca gcaaaatgct gtcaaagaat 1305781 atttgaactt gaaaaaatta attggtgagg tttcagccct gttagaaacg caggcgaatt 1305841 taaatggcat ttttatcaga acaagttatg aaaaagacag catttatata aacggggatc 1305901 aaaaccaatt aaagcaggta ttcattaatt taatcaaaaa tgcagttgaa tcaatgcctg 1305961 atgggggaac agtagacatt atcataaccg aagatgagca ttctgttcat gttactgtca 1306021 aagacgaagg ggaaggtata cctgaaaagg tactaaaccg gattggagag ccatttttaa 1306081 caacaaaaga aaaaggtacg gggcttggat taatggtgac atttaatatc attgaaaacc 1306141 atcagggagt tatacatgtg gacagccatc ctgaaaaagg cacagcgttt aaaatttcat 1306201 ttccaaaaaa ataaaaacaa cggcttaaac gccgttgttt atcgtctgca ttgcttcacg 1306261 tttttttaat acaaataatt ctaaacggtc taggccttct ctcagcgtgt ccattgagca 1306321 tgcaaaagac agccttacat atccttcacc atatgttgag aacgagctgc ccggcacgag 1306381 tgccacgcca gcgtcttcca aaagagccat actaaaatca aatgaagtca ttccaaatga 1306441 tttaatagaa gggaagatat aaaacgcacc ggacggttta actacgtcaa gtcccatgga 1306501 aacaagacgg tcataaacat agtccagacg ttttttgtat tgttctctca taatcaatgc 1306561 atcgtcaaag ccgtttgtga cagcttcaag cgcggctttt tgagaaatgg atgaggcgca 1306621 cgacacattg tattgatgaa cctttaaaat gtgctttgca atgtctttcg gtgcaaataa 1306681 aaatccaatt ctccaaccgg tcatgctgtg tgattttgac aacccgttaa tgacaatcgt 1306741 ttgatcccgc aaataggttg cgatggagta atgcggtctg tcatatgtta attcactgta 1306801 tatttcatca gacaatacga agacatttct gccttttaag agagctgcga tgcttttcag 1306861 ttcttcttca gataaagtca cgccggtagg gtttgacgga taaggaagca cgacacactt 1306921 ggtgttgggt gtcagagcat cttcaatcag ccgggcggta agcttaaagc cgtgtgacgt 1306981 agtatcaaca atgacaggct tggccccgca caaattgata ataggttcat agcccggata 1307041 aataggccct ggcataatga cttcatcacc gggagataaa atcgtccgga atgcagcatc 1307101 aatggcttgg cttgcgcctg ttgtgatgat aatttcagat tcagcatcat agttgaaatc 1307161 cgcttttttc ttcatataaa gctgcacagc ttgtctcagc tccaggtagc cggcattcgg 1307221 agtatatgac gtcacgtttt catcaatggc tttttttgcg gcagctttca catgatgcgg 1307281 tgtgaaaaaa tcaggctggc cgattgtaag tgaaatgacg tcttcgtgtt gggctacaag 1307341 attcgagaat ttgcgtattc ctgaaatttc gatctctctt gctttcggat tcagcaaatg 1307401 ttccataatt catcacctta acaaatataa tgagtttatc ctattttacc actagctgat 1307461 catttgtcac ctttttaact gatatatttc gattgtatgc gccttttttc taaacatacc 1307521 tttcttttca gaaaaaaaga agacaaccag cgatttgatt gtctttattg tatcatgttc 1307581 tattattgtt tatatgtgcc aatttcatta atagccataa tcaaaatgaa ggtcttcgtg 1307641 ccaaatcaga tacggaggat gctcttcttg aaggtcagct gattctttct tcatattcag 1307701 gtaagtttct tcactgatat cctctaaaac agtcatttcg ttttctttaa atattactaa 1307761 ggtacccatt atttacaccc ttctttggaa aaatccttga ctattttatc actgttagtt 1307821 ggaaagtcaa tggttattag gaaaaaagtt tcttttttga ggaacgcggc ttgttgcctt 1307881 cggaattcga ttttgaagag ctgccattca ctttttacaa attacgccga tatatacagt 1307941 acaatactga atgcgaatag cgagggattg aattgtcgtt acaacaatac gaaattttat 1308001 tggattctgg tacaaatgaa ttagaaattg tgaagtttgg cgtgggtgaa aatgctttcg 1308061 gaattaacgt catgaaggta agagaaatta ttcagcctgt cgaggtgaca tcagtgcctc 1308121 actcccatca gcatgtagaa ggaatgatta aactcagagg agaaatcctc cctgtgatca 1308181 gtctcttctc attttttgga gtagagcctg aaggatcaaa agatgagaaa tatatcgtga 1308241 ctgaatttaa taaacggaaa attgtttttc atgtcggctc tgtttctcaa attcacagag 1308301 tatcctggga agcgattgaa aagccgacat cgttaaatca aggaatggag cggcacctta 1308361 ccggtattat taagctcgaa gacctgatga tctttttgcc tgactatgaa aaaattattt 1308421 atgacattga atcagattca ggtgttgaca cgtataatat gcataccgag ggcttcgatg 1308481 aaagaagaac tgataaaaag cttatcattg tagaggactc accgcttttg atgcgcctct 1308541 tgcaggatga attaaaagaa gcagggtaca acaatatcgc ttcgtttgaa aatggaaaag 1308601 aggcatatga atacattatg aaccttgctg aaaacgaaac tgatttatca aaacagattg 1308661 atatgatcat cactgatatt gaaatgccaa aaatggacgg acacaggctc acaaagctgc 1308721 tgaaggaaaa tccgaaaagc tcagatgtgc cggttatgat tttctcatcg ttaattacgg 1308781 atgatctgcg tcaccgcggc gaagttgtag gcgcagatga gcaaatcagc aagcctgaga 1308841 tcagtgattt gattaaaaaa gtggatacgt atgttattga ataaataaaa acagccgttg 1308901 ccagaaagag gcacggctgt ttttatttta aaagtaactc tcgccaagtt ttttaaagac 1308961 cggtttatgg taagctggct gctggcgatt tggcactagc ggcttttctt tcatgccgac 1309021 atattcttgc aataggtgtt tcgcttttgt taaagacatt tgagctttag gatttcgata 1309081 cgattgatta agtgtaccta aatgcggaag atgttcgaag tcttctttag ttggaggcat 1309141 gtgaaaatag tagtctccga ttgagataag cacgtccgat tgctgttggc tgaaccttgg 1309201 attttttgaa aaatgaagcc ctattttctt tcctttacct tctttgacaa gcttttgcaa 1309261 agcccgtttt ttcagcagat ataggtattt agggttgggg gcggtttttg catggcggtt 1309321 cacagtgtaa actgcttttg aaagattttc tacggttggc tgcagatctt tcgtatatgc 1309381 atggtcgtcc attatttctc tcctttgctc ttatcaattt ctatatgttt agattatact 1309441 tttttaaagt tgaaatgcaa atattgaatg taaaaatgcg cttttttcta agaaaaaaag 1309501 cgcattttta acctgcatta tacagatctt gccttctttt tcggctgttc ttgaaatgct 1309561 tcctgaacat tcacttccac agcctgagca ctgtattttg gcagtgcaat aaaataaaaa 1309621 ataaaaacga gcaggataat aacacccatg ccgtaataaa gataatcaat gtttgaaaca 1309681 aacttaggga ataacagcgc gactaagccg agtgtcaaag attgtgcaaa catcataaaa 1309741 gggtcctgca tgccgcttac acgtcccatc agttttggat gaacaatttt tggcatccac 1309801 cctccgattg caatgttgat cggtccgata cacattccca gtgcaaaagc tgccgcgtaa 1309861 tacacccata aaatattggt gtagccgagg acgaagatca gcaaacctgc aatgaaaatc 1309921 ggtatcgaca ttaaaaagtg cggcttcact tttttagaga tgagcgtgcc gattacgctt 1309981 cctgccagaa gcccaaaccc gagtgcgatc gtaaatacag acgtatgcca ctcataacgg 1310041 tcaggcgcca atccatattt cattgtaaac atcggcaata cggcgaatcc tccattgaca 1310101 aatccaaaaa tgaagaagcc aaaaataaga gatgccagca atttgttttt taaaatatag 1310161 aggatgcctt ctctaaagtc atttattgaa tccttaacag aagtctttct ccagctgaat 1310221 gcaccgtttg gctgtcgggc ttcttttgga atccggcagc tgcggatcag cagcccggaa 1310281 atgataaagc tgacaaaatc aagaataatg gcgccttcaa taccgattgt gttgtacata 1310341 aacgcgccta tgccgactcc aaacaccata aaaatgctaa aaagcatctg attaagccct 1310401 gccgctttcg cataatgctc cttcggcaga atggcttgta ccaaactgtt ttctgccgga 1310461 aagaaaaact ttgttacagc gcttctgata aataagatac aaaaaacaag aggaatattg 1310521 ccggtaaata aagtgaaaaa aagcacgaca gtcaggcctg ctctgatcca atcacaattt 1310581 tctgccacct tttttctatc aaaccggtcc gcgacgactc ccacgatcag aaatacaaat 1310641 atggtcggaa gagaatacat cagctccgcc aaggtcgtat atgaaggctg gctgctgaat 1310701 cggtccagca aaaaaaaagc aaaggccatg ttgcctactg tcgtgcccat ttgagaagcg 1310761 agtgctgcga aaaatagacg aacaaaatta cgatttttaa atatatccat aaaaacgctc 1310821 cttaccctaa aggtcccact ttatcatatt ataaaccgcc tgtttttgaa acaaataaga 1310881 aaacattacc ggttaatcgt gactctcgtt ccgtttggca caattgaagc aagttcgatc 1310941 acgtctttgt tatgcatgcg aatgcagcct ttagaaacag ccttaccaat cgaagcggga 1311001 ttattcgtcc catgtattcc gtagtgctgc tttgaaaggc tcagccaata agcgccaaat 1311061 gggccgccgg gattgcgctg gcggttaata atgtaaaact cgccagtagg cgtttgcgtt 1311121 agtattttac caacggcgat gggataggtt ttcattaccc gattatttag ggacagcgta 1311181 agggtcttcg ctccgattga gactgcgata tgatacggaa ttgtataagg gtccggcagt 1311241 ccggggatga ctatggactg tcccgcggtg agccctgcct gcagtgacgg attagcctgg 1311301 agtaatgcag ccgtgctgat tctgaaatca gccgcgatgc tgttcagtgt atcaccttgc 1311361 ttcacctggt acgtaagcag tttcctcatc ctcctttttt acttataagt attgatgagg 1311421 agcccatcct gctacattaa tttgtgcttt ttaaggtgaa gacagtgatt tcaggcttgg 1311481 caagaaaccg caaaggcagc ctggtcatcc cgaggcctcg gtttacgtaa atatgagtgc 1311541 tgcccgtttg atacattccc tctgtgtaga cttttccata tggaggcgta ataatcggtc 1311601 cgtaaaaagg cagctgaatc tggccgccgt gtgtatggcc ggaaagctga aggttcacgg 1311661 gataatctgt tgttttcaag gctgcatcag gttcatggac gagaagaatg gaaaaaagtc 1311721 tgtcgctcag ccttgaaagg gtgccttcat aatctgggtt tcccagcatt aagtcatcaa 1311781 gcgaagcaat ctcgattttg ctgccatctg cgagtgacaa tgtttgatag ccattgcgat 1311841 ataccgtgaa acctccggcc gtcatcaggc ttttgtaaac ggcagttcca tagcctccgt 1311901 gatcatgatt gccgtaaata caaagcttgc cgaagggagc attaagcttt ctcaataatg 1311961 gaatgactgc ctggtggtgc tggtacgtat caggattatc aataatatca cctgtaaaaa 1312021 caatgagatc aggtttagat tcattaattg taagaatgac agtttttaaa tcttcgagag 1312081 taaagtaatc actcaagtgt gcatcgctga actgcacgat tttaaaaccg tcaaatccgt 1312141 gcgggatgag agagcttttt attgtgtgtt cggttgtctc gatcatatgc ggctcgagat 1312201 acctggcata gccatatccc ccgccggccg ttaaagcccc ggcagcaaga gcgccgaaca 1312261 ttccttttag aaattgtctt ctggacatct ttttcatttc aaaccaacct ttaatagagt 1312321 ttttctatta tatcatctgt atctgataaa aatctcatat gagcatgtgc tgacagaggc 1312381 agggatataa tgatagaata ttattgaatg aataatcatt cacaattgga gggataaaca 1312441 tggaaaaaaa ggcggtaatt attaccggcg ggtcaagcgg catgggaaaa gcgatggcaa 1312501 aaaaacaggc tgaattaggg tggcacgtta tggtgacagg gaggaaccat gaggcacttg 1312561 aggaaacaaa aaaagaaatt cagacctttg agggacaggt cgcttgtttt caaatggatg 1312621 tccgttccga ttccgccgct tcagacatga ttaaagaagc ggtaaaagcc tttggccggc 1312681 ttgacgcgct gattaacaac gcggccggaa actttatttg tccggcagaa aagctgacgc 1312741 ccaatggatg gaaagccgtt attgagattg ttttaaacgg cacatttttt tgcagccaag 1312801 cagcggcaag gcattggatt gaccagaagc agcagggtgt cattttaaat atggcagcca 1312861 cgtacgcttg gggagcggga gcgggggtcg ttcattccgc tgcagccaaa gcgggggtat 1312921 tgtcattgac aagaacgctg gccgttgaat gggggagcaa atacggcatt cgtacaaacg 1312981 cgatagcccc cggaccgatt gaacgaacag gcggtgcgga gaagctattt gaatcggaaa 1313041 aagcgatggc ccgcacgatg aacagtgtgc cgctcggccg attgggcaca ccggaggaaa 1313101 tcgccgcttt ggcagcgttt ttgctttctg atgaagcatc ctatataaac ggggattgta 1313161 tcacaatgga cggggggcaa tggctgaatc cttatccgtt ttaatctgaa tatttataag 1313221 tgaatattta agttattaag aacttttatg ttcgaatgta atacctccac aattaacctt 1313281 cttcctatcc aatttgataa cacatagagc tttatttgtt tatgaggtgt tgtgtcatac 1313341 gtaagccacc taatatatga aaggtatatt ttaaaagggg agacgaaata tgaagaactt 1313401 agatttcaaa taaaacattc atataattac ttcgttaact aaaaagagaa attataagaa 1313461 tgaaaggttt caaggttaca tcagattggg aggaaggtaa tataatggac gagatggtat 1313521 tattaactca ggaatggctc aatgaaacgt acaaaggaaa aagtggctac aattccattg 1313581 aggaaaatgg gaaaactggc tggaaaacaa tgtatgcatt aactagagca ttacaactag 1313641 aattgggaat tacacagact tccgacagtt ttggtcctac aactttaaga aagcttaaag 1313701 aattaggccc gatttctacg tcaactaatt caaaaaaaaa tattgtgaaa attattcaag 1313761 gtgctcttta ttgtaaaggt tatggtccag gtggattaac gggtacattt ggtcagggaa 1313821 cgaaagaggc gatagcagaa atgcaattgc atatggggct ttctaaaaca gacggtgtag 1313881 taacgcctaa ggtgtttaaa gctttattaa acatggactc ttatatcctt ttaaatgggg 1313941 cgtcagagaa agttcgttca atacagcaat ggctaaataa taaatattac aatagagaga 1314001 atttctactt tatgccctgt gatggcctgt attcaaggga tactcaaaag tctcttgttt 1314061 atgcaataca gtacgaggaa gggttaagtg atagtatagc taatgggaat tttggaccaa 1314121 ctactcaaag attgattcct gtattaagaa ttggagaaac agatgaaaaa aacagtttta 1314181 ttcatttatt tcaagctgct ctaatcttta atggctacaa tgttcctttt gatggagtat 1314241 actctgaatc tgtaagatca aaagtaaagg cttttcagtc ttttgcaaaa ttacaacaga 1314301 gtggtactgc cgactttcaa acatgggctt cacttctagt aagtactgga gaccccaatc 1314361 gaaaaggagt tgcttgtgac tcaattactc aaattacatc ggacagggcg gagtccctta 1314421 agagggcagg ttataagatt gtagggcggt atctaacaaa tgcgccgggg agtacactaa 1314481 ataaaaaaat acaaccaggt gaattagaaa ctatcttaaa atcaggttta aatgtttttc 1314541 cgatttatca aacctatggg ggagcaacaa attattttaa taaagaacaa ggaaagaaag 1314601 atgcgtttgc tgcttataaa gcagcaaaag aatacgggtt taaaaataac actgtaatat 1314661 actttgcagt agattatgat gcatatggta acgatttaaa caacaatatt attccacact 1314721 tcgaaggtat aaatgaaata atgaacggtt ttttaggttc aacttacaaa attggtattt 1314781 atgcccctag gaatgtatgt actatagttt ctaaaaaagg tttagcattt gcaagttttg 1314841 taagtggtat gtctactggc tttagcggaa acttaggata tcctttgcct tacaattggg 1314901 cgtttgacca aatttcaaca attactgttg gaaatggttc tggaatgatt gaaattgata 1314961 atgatatttg ttcaggtttg gataatggag ttaataccat aaatatagtg ccttcagaga 1315021 ataagaagtt ttttgatcaa attgatgttt tatatgaaac tgctgaaaaa tatgctcaaa 1315081 tgcaaagcga cttaaataat ggggtaaaaa aaacacaatt agctaatgag ttggttgccc 1315141 agtatttaag aaaggatgac tacaaagggt ggaagtgggt ccctaccgca ggccagattg 1315201 atcctattta tcgtgaatgg gcagtaaagc gctaggggaa gacctagtaa atggaattgt 1315261 tgatcctata tcaaaaactg tcataggaac gcagcatctt atggcaactt ataatgccat 1315321 tatttatagt ggtggttact ctcaaacact acgagatttt gctggttgga ctggagatct 1315381 attaacaaca atacaggaca tgaaattaca cgctcaagaa tttaattcgc cttatgatgc 1315441 ggctatgaaa ataataggta atatgtatca atttagccta gatgatttat ttagtgatgt 1315501 agatgcaatt aatctagcga ataaaacatc agttggtgct aatgcacaac ctctaaatat 1315561 cgcaattaga gattattata gtaataatga ctgtatgaat aggttcactc aatttgtaaa 1315621 taatagattt gatggttcgt tagacaaaat tttctctgaa gcagagtatt atttaaatac 1315681 aaaccttgac ccagttgttg ttccaattag gttagccttt aaacgtgctt ttgatgttga 1315741 ggattatagt gaagagattg gaaaaataac agcacaagca tttagagatg ttatcgagaa 1315801 aaaaatgata tctgaataaa ctgcaaaaca agcgaacgtt aaaactggtc gttcgcttgt 1315861 tttattttct atttaaattt atgatataat ttttaaagat taaggagtga ttcattgaag 1315921 aaattgttaa aaaagttagt tgtattattt ttaagcagtt tagttatcat ctttaatgtt 1315981 tggtacttta ttatttgtgc tttttcccca gagtattatc aaaatacaaa tcttacttct 1316041 aatgaaataa taagatttga aaaactatac cacatagatt ttcctgatga aacaaaattt 1316101 attaaagcta gagagtattt ggctgggccc ggaggagata cgtcagctgt attatatgtg 1316161 tctctgccaa ccaagcgggt agaaaaagtt ttatctgatt acacgtatat gaaaataaac 1316221 tatactgaca atgtcggttc aatgtatgga gttgacgttt caaagagtgt cgccggttta 1316281 acaactctta catttggcac ttacgataaa aaaggaactt tctataatat gaaacatgat 1316341 gatgattgga tgtataaagg cactgactgg aatctttact tttggacagc tgctagttat 1316401 aatgctgtta tttttgtatt tgttttggtt attgtgaaac aaatgaataa aattcttaat 1316461 taaccagtat gtagattgat aatctcaaaa aaattttcct cttcttttaa catactccat 1316521 acgacctact tttccatact atgatttttt tgaaatttgt ggtgtagtta taattgtgcg 1316581 tataatcaga caaagataga gaagcaggtg ataacatgtt ggatccactt gatattttaa 1316641 cgaacattga tgatgtcctt ccatattacc aggcgatttt tagtgccgag gagcagaagg 1316701 ttgtcggata tgaggtgctt ggacgaattt tggcagattc agaaatccaa agtctcgggc 1316761 ccttcttttt agatgcgggg atacccgaag aatataaatt agaggttgat aacagaatta 1316821 tccgccaggc tcttgaccgc tttttagagg cggattctga tctgctgatt tttatgaatc 1316881 aggatgccaa tctgctgatg ctggatcatg gtgaaagctt tctggagctt ctgaaagaat 1316941 atgaagcgaa gggaatcgaa ctccaccgtt ttgtgcttga aattacagag cacaattttg 1317001 aaggggatat tgagcagctc taccatatgc ttgcatacta tcgtacatac ggaattaaaa 1317061 tcgcagttga caacatcgga aaagaaagca gcaacttgga cagaatcgcg ctgctctcac 1317121 cagatctgtt aaaaatcgat ttgcaggcgc tgaaagtgtc acagccgtca ccgtcatatg 1317181 agcatgtgct gtacagcata tctttattag caagaaaaat cggtgcggcg ctgctgtatg 1317241 aagacattga ggcgaacttc cagcttcagt acgcctggag aaacggaggc cgctattttc 1317301 agggctatta cttagtgtct ccatctgaaa cgtttctaga gagagatgta ttgaaacaaa 1317361 gacttaaaac tgaatttcac caatttatca cacatgagaa aaagaaactg gagaccgtct 1317421 atgagcactc tgaacagttt tacaaacgag tgcatcaggc tgtgacctct ttgagaaaaa 1317481 acaatctgtc ttctgatgat gactttatta aaaagctggc ggaagagctg acagattgca 1317541 gcttcaggat ttacatgtgt gatgaagaag gcgatcagct gacgggaaat gtgtttaagc 1317601 aagatggaga atggatttat cagccggaat atgcggaaaa gaactggagc tggcgccctt 1317661 attttctgga gaacattatg agaatgagaa atctcagaaa aggttttttc agtgatctgt 1317721 acagtgattt ggaaacaggt gaaatgatca gaacgttttc atatccgatg gatgatcaga 1317781 tgtatttatt tatagacttg ccttattctt atttatatga gcaggacgga ctgatttaac 1317841 ggctgaaagg ccgttttttt tatgaaatga aaaaaatatc aaaaaacgat tgacattgat 1317901 actgagaatc attatcattt aattatagag agaagctact ctctgttccc caacccctct 1317961 atcagatcaa gatccgaaaa aacttggcgc tacccccgcc aagtttttta tttgtcaaag 1318021 cataggacaa tccaatgaaa caataaacct aactagtggt aaacgtttaa cacggggaga 1318081 aacattgagt gccgaacacc cctgacactg ctgcacgggt gaggaggaaa attcgttctg 1318141 aaatgattat ttcagttccg ttgtttacct ctatccagca tgactcccat tgattatggc 1318201 cacgcgggac ttcaccataa aattcaaaag aaggttttga caaagttgca aaaaggcatt 1318261 cttaatgctg ccaaagattc gaaaaaaatt ataattatgt gcatgacatt caaaaaaagc 1318321 ctcaaactaa agaaaaatag tttttttcac tttttttctt tgcttaaatt cagcagtgaa 1318381 aatgccatcc tgtccgactt tatggtatga tgctcaatag aacttgtatt ataataaata 1318441 cttgttgatt tgaagttgct ttttgaaagg agtctttttt tagaatgtca caattaatgg 1318501 gtatcatcac acggctgcaa agtctgcaag aaacagcgga agcggctaac gagccaatgc 1318561 agcgttattt cgaagtgaat ggtgagaaaa tatgcagtgt taaatatttc gaaaaaaatc 1318621 aaacgtttga actgacggtt ttccaaaagg gtgaaaaacc taacacatat ccgtttgata 1318681 atatcgacat ggtttccatc gaaatctttg aacttcttca gtaagattcc tgaaataggg 1318741 ggaacaagct tccgcctttg caaaagtaat cgaaataaac ggtaaggaac atacttgttt 1318801 catggttgta aatccttgaa aaggagtgtc gtgatggctg attcttttct gttttataat 1318861 ctttcagaag cacagatgac ctttcaagat gtgatggaac ggcttaaagc ctttgttcaa 1318921 aaggaccccc gttcttctta tgtgttatcg atcggaaccg attcacaggt ttaccgcgat 1318981 tacacaaagt ttattaccgc attgcatttg catcgtacag gcaagggagc ttggggctgc 1319041 ttgaaaaatc atacagtcga cagacccata catagccttc gggagaagat ttcgttagaa 1319101 acggcgtaca gccaagaaac ggccgctcat attcttgatg gacacttaat ggatattacc 1319161 gatctgctcc tgccctttac cggtgagggg gcggatctta cctttgaagt tcacttggat 1319221 attgggaaaa aagggcttac aaaagatctg atccaagaaa tgactggacg tattacctcc 1319281 atggggattg aggccaaaat aaagccggat tcatacactg ccttcagcta tgcaaatcgt 1319341 ttcacaaaat aatttggctg aaaaagccaa ggtaaatgtc gaattatgcg gttgacgttt 1319401 gttatctgat tacttattct agcggtagag ctgaaagtaa gttgtcttgc tttcagaggt 1319461 attcagtata aaacaggggg cctgattgcg aatgagtctt atcggtgaac gatttacaga 1319521 agaagaacaa aaacttctgc tgaatatcct gatcaaccat gagtatgcca tcgagctatt 1319581 aagcagtgag atcaacgata tagagacagg gaccaaaaac gttgacggaa ccacctacaa 1319641 aaaacttgta acgctatacg accgatttcg atttgaaaat taatgggaca ccctataatt 1319701 gatactccac aaagagtatc ttttttattg aaaggaaact tttcgacaaa tactgataaa 1319761 gtttatatta ttgcaatata gggaatgtat tgatgatgaa aatgaaaagg ggtcgaaaac 1319821 atgataagct tacaatcaga tcaacttctt gaggcaacag tcggacaatt tatgattgag 1319881 gcggacaaag tagcgcacgt gcaagtcgga aataaccttg agcatgcatt attagtattg 1319941 acaaaaaccg gatacacagc catcccggtt ctggatcctt cctaccgttt acatggctta 1320001 atcgggacaa atatgatcat gaacagtatt tttggacttg agcgaattga gtttgaaaag 1320061 cttgaccaaa tcactgttga ggaagtcatg ctgaccgaca ttccgcgcct tcatatcaat 1320121 gatccgatta tgaagggatt cggcatggtc attaataacg gatttgtctg tgttgaaaat 1320181 gacgagcagg tatttgaagg gatttttacg agaagagtcg ttttaaagga attgaataag 1320241 catatacgct cattgaataa gtaggctgta cggtcctatt tttattatat aggcagagtg 1320301 aaaaaagaaa gcgcatacat aatttaaacg agaatagggc ttgaataaga aactaagatt 1320361 ttattagaat gggagataag aaaaacttat tgataacaaa aaggaggacg acatgcagct 1320421 tcaagagctt catatgctcg tagttttagc tgaggaatta aatatgagaa aggcggcaga 1320481 acggcttttt gtatctcagc cggctttatc tcagcgctta caaaccattg aaaaggcgtg 1320541 gggaacaaaa atctttttaa gatctcaaaa aggattaacg gtaacgcccg ccggtgagaa 1320601 aatcattcag tttgcgaatg atgtgacatt agagcaggaa agaataagag aaaatattga 1320661 cgagcttgaa ggtgaaattc acggcacatt gaagcttgcc gtcgcctcca taatcggtca 1320721 gcattggctc cctaaagtcc tgaagacgta tgtggaaaag tatccgaatg caaagatctc 1320781 gctcataacc gggtggagca gcgaaatgct gaaaagcttg tatgaggatc aggttcatat 1320841 cggcattata agaggcaacc ctgagtggaa ggggcgcaaa gattacttaa tgacagatca 1320901 tctgtattta gtggatactg aaatttcctg catcgaagat attgcccata cagaacgtcc 1320961 gtttatccag tttaaaagtg acagcactta ttttcaggaa attcagcact ggtggcatca 1321021 aaaatttaaa acgtcgccga aacagacgat attggttgat cagattgaaa cgtgcaaaca 1321081 gatggcgctg cacggaatcg gttatgccat tttgccgtct gttacccttc aaaatgaaga 1321141 taaagtgaat aaaatgcctc ttttagacat gaaagggcat ccgatcggtc gggatacatg 1321201 gttattaggt tatgagcctg cctttgaact gaaacaagtt caagcttttg tacaagtgat 1321261 aaaggatatg ctggatcagg aaaatccatt ttaaagacag cgaggtgctg tctttttttt 1321321 atttatctgt tgacaatgaa aatcattatc atttaaagtg atacatatga tattgaaaat 1321381 cattatcaac taatggggtg ataacatggc taaagccttg attacatatg ccagcatgtc 1321441 aggaaataca gaagacattg ccttcataat aaaagatacg cttcaggaat atgagttgga 1321501 tatcgattgt gtcgagataa atgatatgga tgcgtcttgt ttaacctcct atgattatgt 1321561 actgattggc acctatacat ggggggacgg cgatttgccc tacgaagcgg aggatttttt 1321621 cgaagaggtc aaacagattc agcttaatgg tttaaaaaca gcctgcttcg ggtctggcga 1321681 ttattcttat ccaaagtttt gcgaagcggt gaatttgttc aatgtcatgc tgcaagaggc 1321741 gggagctgct gtttaccagg aaacactaaa aattgaatta gcgcctgaaa cagatgaaga 1321801 tgtggaaagc tgccgagcgt ttgcgagagg ttttcttgca tgggcagatt atatgaacaa 1321861 ggaaaaaatc catgtttcat aaaggggcaa ccgctgttac ggcatcggcg ttttctggat 1321921 attttgtggc ggtacaaaga gaaggcattt ttcattactc tttggagcag ggctggagaa 1321981 agctttttcg tttgaaaagt aagatacact gtatcagcta catagggcct tacttatttg 1322041 gcgttggtga aaagggaaca gtcattcgtt cggctgatga agggaaaacc tggacgatgt 1322101 cgagctttcc gacaaatgca acagtgtggg cgattaccgg cagaaacaac gggtttgtct 1322161 gcgcccacgg taagcattgt atttatgtat cggatgattt tggtgtctca tggcgcgtag 1322221 ccaaaccttt tgccgaattt cataatcccc ctgttatccg gtcgttatgc cttcacgggg 1322281 gcaatctctt tatcggcacg caaatacacg aatattttgg cggcatttgg gcttacgaca 1322341 ttaagcgtga cactgtccaa gttgtcaaaa aagaaaaaaa ccggatgacg gcatccatgc 1322401 tcgtgttcaa tgaaaattgg ctggtggcgg cgatgggttc tgtgaaagga aagcacggtg 1322461 ctgtcactgt aaggaatctt ttgaatggtg aagaattcac catacaatcc agtatgatca 1322521 gaaatgaaga atcatttctt gatctttcag aggatgatgg cattatatat gtcactacaa 1322581 cacaagatga aaatggtttt tcgagaattt accaggttga tctcgaagcc cggtcgttaa 1322641 aatggttcga taccattaag ggacatggat ggagagtggc caatcagaaa gagaatttct 1322701 tttgcgcagg cttgtatgaa tgtaaatttg tccagccgta cgaagtttca gcaatgattc 1322761 attagaggag gaacaaggaa ttggcgaaga ttttgctcgt ttatgcaaca atgtcaggca 1322821 acactgaagc tatggcagat ttgattgaaa aggggcttca ggaggcgtta gcagaagtag 1322881 accgtttcga agcaatggat attgatgatg cccagctgtt taccgattat gaccatgtca 1322941 taatgggaac ctacacgtgg ggagacggag atctgcctga tgaattttta gatcttgttg 1323001 aagacatgga ggagattgat ttttccggca aaacatgcgc tgtattcggt tccggtgata 1323061 cagcatatga atttttctgc ggagcggttg atacgctaga ggcaaaaata aaagaacgcg 1323121 gtggagacat tgtgctgcct tcggtaaaaa tcgaaaataa tccagaaggt gaagaagagg 1323181 aagaattaat aaacttcggg agacaattcg caaagaaaag cgggtgcgct gtctgatcac 1323241 tcactgggaa ctgctaaaac ggctgttcct ttttttcttg tctttgtatc tttcctttga 1323301 tacagtaatg aggtagaaaa tcaggaggag gactatacat atgaaaatga tggacgcaaa 1323361 tgaaattatt tcatttattc aaaatagtac aaaatctaca cctgtaaagg tttacgtgaa 1323421 aggtgagctg gaaggaatca atttcggtga atctgcgaaa gcttttatca atggaaacac 1323481 tggtgtcgtt ttcggtgaat ggagcgaaat ccaaacagca atcgaagaaa accaaagcaa 1323541 aatcgaagac tatgtggttg aaaatgaccg ccgcaattct gcgatcccaa tgcttgatct 1323601 taaaaacatc aaagcgcgta tcgagccggg tgcgatcatc cgcgaccaag ttgaaatcgg 1323661 tgataacgca gtcatcatga tgggtgcttc tattaatatc ggttcagtca tcggcgaagg 1323721 cacaatgatt gatatgaacg ttgtgcttgg cggacgagct actgttggaa aaaactgcca 1323781 tatcggcgcg ggttctgtac ttgcgggcgt tattgagccg ccatccgcta aaccggttgt 1323841 gattgaagac gacgtcgtaa tcggcgcaaa tgctgttgtg cttgaaggtg taacagtagg 1323901 taaaggagct gttgttgctg cgggagcgat cgtggtaaac gacgttgagc catacactgt 1323961 cgttgcaggc acaccagcta aaaaaatcaa agacattgat gaaaaaacaa aaggcaaaac 1324021 tgaaatcaag caggaattac gccagctgta aggaaaagtt tgataaaaaa ggcgtggata 1324081 atatatccac gccttattcg tataggcagg aggaatagaa atgaagatag aggagctcat 1324141 cgcaattcgc agagatctgc atcgtatacc ggagcttgga tttcaggagt tcaaaaccca 1324201 gcagtattta ttaaatgtct tggaacaata tccgcaagac agaattgaaa ttgagaaatg 1324261 gcgaacaggg ctttttgtaa aagtgaacgg gacggcgccg gaaaaaatgc tggcatacag 1324321 agcggatatc gatgcgcttt ctatagaaga gcaaactggt cttccattcg catcagagca 1324381 tcacggcaac atgcacgcct gcggtcacga tttgcatatg acaattgcac tcggcattat 1324441 tgatcatttt gttcaccacc cagtcaaaca tgatttgctt tttctgtttc agccggcaga 1324501 ggaagggcct ggcggtgcgg aaccaatgct tgagagcgat gtattaaaaa aatggcagcc 1324561 tgatttcatc actgcccttc atattgctcc agagcttccg gtaggcacca ttgcgacaaa 1324621 aagcggcctt ctatttgcga atacatcaga gctagtcatc gatctggaag gcaaaggggg 1324681 acatgcggca tatccgcatt tggctgagga tatggttgta gcagcaagta cacttgtcac 1324741 ccagctgcaa acgattatct ctagaaacac agatccgcta gacagtgctg ttattacagt 1324801 tggtaccatt accggaggct cggcacaaaa tatcattgca gaaacggccc acctggaagg 1324861 cacgatccgc acgctttctg aagaatcgat gaaacaagta aaggaacgga ttgaagatgt 1324921 agtgaaagga atcgaaatcg gattccgctg caaaggaaaa gtgacatatc cgtctgtata 1324981 tcaccaagtt tacaatacga gcggattaac agaagaattt atgtcttttg ttgctgaaca 1325041 tcaactggcg acagtaattg aagcaaaaga agcaatgact ggagaggatt ttggctatat 1325101 gctgaaaaaa tatcccggat tcatgttctg gctcggcgct gattctgaac atgggcttca 1325161 tcatgctaag ctgaatcccg atgaaaatgc gatagaaaca gcggttcatg tcatgacagg 1325221 ttatttttct gtttatgcca attaagtaca aatgaaagaa taaaattcca taaaatgagc 1325281 actctagtaa acggaggtgt tcaaaaatgg ctaaaaaaat tggaattgaa caatcgttat 1325341 cagatgtaga agctgcttta aaagaaaaag gatatgacgt tgtaatgatg aaaagccctg 1325401 ctgatgctca aggctgtgac tgctgtgtcg taacaggtct tgataataat gtgcaaggga 1325461 tagccgatac ggtaacacaa gcacctgtca ttacagcttc cgggatgacg gctgaagaaa 1325521 tttgtagcga agttgagagc agaattcagt aataaaaaaa ccgaagcaaa aagcttcggt 1325581 tcttttattt attctgtttc tttagggaaa gcgcggtcga acgcgttctt tatttctttt 1325641 ctcaacactc gttcgactcg ccactgttcc atattttctg ttttggcaat gaccctgatt 1325701 acaatttcag aagtccccag ttcttgaatc ccgatgacat ttgggccttc ttttatttgt 1325761 ggaagagccg ctgccgtttc atcacaaacc tgctgtaaaa tatgaatcat ttcatcaata 1325821 tttctttcag ccggcacttt aatgtcaaca agagcctgca tggtaccacg agaatgattg 1325881 ctcacgtttg tgatgtttct gttggggatg taatgcagtg ttccgtcaaa gctgcggatt 1325941 tgagttgtcc ttaagccaac ctgctcgaca attccgtcaa aggtggaaac ggtaatataa 1326001 tctccgacat ccaattgttt ctcaagcaaa ataaaaaaac ctgtcacgat atcactgaca 1326061 agcccttggg cgccaaatcc gacagccagg ccgacgattc ctgcccccgc taaaagagcg 1326121 cttggatcat aatgaaacaa atctagaacc atgacgaaaa atatgaaaat caatgtataa 1326181 gcaaatatgt taagagtcag gcttcggagc gtatgtgcac gtccgataga caagctattc 1326241 tgctcctcga attttgcaaa cagatgttta atgattttca tgcctaatga tcgaacgata 1326301 aaatagagca atatcataat ggcgagttta atgagcagaa caccggcatt tgtaatcagt 1326361 cccgcccaat catattgttt aataaagtcc atgttgagct ccttttctaa ttgattgctg 1326421 cacattgaga ctagttaccc tgtacatgac catgttaaac gttttattca aaaatgtcga 1326481 agccaaagac atacatgatt tgttaaaaat tgactcagga aatctgcttt tatataatgg 1326541 cattgcaata taactaaaaa tggttaatca ccctttattt tcatgcgatt ttgaccttta 1326601 agccaaacaa taaattggag ggatacatat ggcagaacgt atggtaggta aacaagctcc 1326661 tcgttttgaa atggaagcag tccttgcaag caaagaattc ggcaaagtaa gtcttgagga 1326721 aaacatgaaa aacgacaaat ggacagtgct gttcttctat ccaatggact tcacttttgt 1326781 ttgtccgaca gaaattacag caatgtctga ccgctatgac gagttcgaag atcttgatgc 1326841 agaagtcatc ggggtttcaa ctgataccat ccatactcat ttagcttgga tcaatacaga 1326901 ccgcaaagaa aacggtcttg gccagctgaa atacccgctt gctgctgata caaaccatga 1326961 ggtatcccgg gaatatggcg ttttaatcga agaagaaggt gtggctttgc gcggattgtt 1327021 tattattaat cctgaagggg agcttcaata tcaaactgtt ttccataaca acattgggcg 1327081 tgatgttgat gaaacgcttc gtgttctcca ggcgctgcaa actggcggac tctgtccggc 1327141 taactggaaa ccaggccaaa aaacacttta attctttcca agaacgaaaa gcggtctagc 1327201 atattcgtta ggcctctctt ttaaaatagg agggaaaaag caatgaaatt acgtcagccc 1327261 atgccggaat tgacgggaga aaaagcttgg ttaaatggtg aagtgacgag agagcaattg 1327321 attggggaaa agccgacgct tattcatttc tggtccatca gctgccactt gtgcaaagaa 1327381 gcgatgccgc aagtgaatga atttcgtgat aaatatcaag atcagctgaa tgttgtagct 1327441 gtacacatgc cccgttccga agatgatctt gaccctggta aaattaaaga aacagctgct 1327501 gaacacgata tcactcagcc gatttttgtt gacagtgacc atgctttaac cgatgcattt 1327561 gaaaatgaat atgtacctgc atattatgtg tttgataaaa caggacagct ccgtcacttc 1327621 caagccggcg ggagcggtat gaaaatgctt gaaaaacgtg tgaaccgcgt tctggctgaa 1327681 acggaatagg tatctgacta aatagtattt cctaaaaacc tgacctcatc aggtttttta 1327741 tttgtgcaaa aagcaatgga agaagagtaa gaagcttatt tttccaaatt tgggtatagg 1327801 aattgatgat ttgtttgatt gatacgctaa aaaacacagc taatttttga tgtttttcct 1327861 caattttaga taaatctcat atctcataac tcgaaaattg tagatattac actaaatttc 1327921 tttaaagaag taagtaaaat atatattttc aacattatac caaataaact agaaagcccc 1327981 ttaatccctt gagaataaag gactcttttg aaaaataaaa cattttcaga aaataaggaa 1328041 tttttcatag agtaaatata atagtaaaat gctaaaataa tagttgataa aattactttt 1328101 gtaatctaat atcttaatta aagatgttaa ttttgatagg gggtacattg aggaatgttt 1328161 aatgaaagag aagctttgcg cttgcggtta gaacaattaa atgaagctga agtgaaagtc 1328221 attcgtgaat atcaaattga acgtgataaa atatacgcaa aattaagaga gctggacaga 1328281 aatggaagcc cttccgaaat caaaaaggat ttccgttctg aaaaaaaacc tgactctctg 1328341 ccggttctcg ctgagcttgc ggctcaggaa atcagaagct atcagccgca atcacagcag 1328401 cagtctgttc agcctcagct tcaatctatt tcctctcttc ctgccggtat accagacgga 1328461 acaacacgaa gaagaagagg aacggcaaga ccgggatcaa aagcagctaa gctgcgtgaa 1328521 gctgctatta aaacattaaa acgccacaac gcggcgatta agagctcgga gcttcaaaaa 1328581 gagattgaaa aagaaagcgg tcttgaaatc cctaatatga caacgtttat gcaaagctta 1328641 attaaaatgt acccggaagt gaaaaagcca tatcgcgggc agtacatttt agagggtgaa 1328701 atcgaatctg cagaatcagc aaacgaataa atataaagaa aaactgcttg gcatcgctca 1328761 agcagttttt ttattgaggt tttttctgtg aaggtttgtt ttctttttca agattaagct 1328821 tatacaccca cttttgataa ggcttttctt cagcggctct gtttttcagc tcttcgattg 1328881 tatggctctt ggcctggtct gatgattggg cgtgggcaag ctgtttttga agcacatgta 1328941 tctgtttggt gacatcttca aggatagtct ctacatgatt tggctgcgcg taggccgctg 1329001 gagcttcttc ttccgttttt tctttttgtt tcgtgccgcc atcaatatcg gcaaaatgag 1329061 aagcaatcca ggcatcgctt tcatcaagtt gccgtttata cgatataata gtttcgtgaa 1329121 ataatttttc tttcgttttt tctatgtcta gcagtctttc tttcgtttct atgattcgat 1329181 ctttcatatg atcaacttct attttaatat gttttagctg atattctttt tctaccattt 1329241 gctcttttag acgcccgttt tcggctttta tcaattcggc ttgctgtttt gcctgaagca 1329301 gtgcattttg ttcctgctca attgaggctt gaagttcgct gatccgttta tgaagatttt 1329361 tattttcttc ttcgattttg actttcgcaa tatgaagttt atgtttttct tcgatttcgg 1329421 ctctgcgttt ataggtttca gcagatagaa gctcctgcaa aacaacgatt ttatcaagca 1329481 gttcagctct tatttggtgc agggtttggc tggtgtggga ggcatgtttt tcttttgttg 1329541 acatatgtgt taattcggca gacagctgct ggagtttttc tttcatatcg gtattttctt 1329601 tgagcagttt gttatttttc tgatgaaagt agcttgcttc aagttcagaa atcagcttat 1329661 ggcaccttga aagctcggat tttaaataaa ggttctcctg agacacgtcg tggaaaaaag 1329721 gacctgatct tttcattcga accatctccc tcatgatgtt aacactacaa tatgcaaata 1329781 ctgaacagct attcctcttt aataaacaga caagcagtag cgttgagcct ttgcttttgc 1329841 tatgctttta acgaaactag aggtgagatg atatgaagca tgtaaacgta ctgctggcag 1329901 ggggagcctc acgtcgcttt ggagaaccga aggcgtttgt caaatggaag ggcaggatgc 1329961 tttacgaatg cgctaaagag gcacttggag aacaaacggt tatcatcagc cgtcccgaat 1330021 ttattgatag atttcaagaa aacggtgaaa atgaagtgta tcaagatgct gagccatttc 1330081 aaggcatggg gccattggct ggtatatata ccgcttttaa aaagacagac ggtgatcttt 1330141 atactgttct ttcctgtgac acaccgctga tacaaagaag gacgatgctg gagctcaaac 1330201 gtctgatgat tgccggtgcg gacgcggtag tcccaatttc agacggacaa gtgcagccat 1330261 tgattgcgat ttaccacaaa cgtatcatgc cagttctata cgatcagctt tctgagaaga 1330321 ggttgagaat atcagattta ttaggcagaa tttcggtttg ttacgtacag gctgaaaata 1330381 tcggagcaaa cccggcagag tttatcaaca ttaatacacg tgatgatttt agctgtttgg 1330441 aagaaaaatc gaactccctc aagcgggact gacggggcaa taacatgata agatgacata 1330501 aaagataagg agaacaggtt tgatggagga acgttattca cggcaaatca gatttaagca 1330561 aattggggaa gagggccaga aaagactggc agacagccat gtgctgattg tcggagcggg 1330621 agcgctcggc actgcaggag ctgaagggct ttcgagagcg ggagtcggta cgattaccat 1330681 tattgaccgt gactatgtgg agtggagcaa tcttcaaagg cagcagcttt atacagaaag 1330741 cgatgccaaa ctccgcatgc cgaaagccat ggctgccaaa gagcatctat cagcgattaa 1330801 cagcgagata catattgagg cgtatgttac cgaaggaaca gccgaaacgc ttgagccgct 1330861 gattgaaaaa gcagatgtcg tgatcgacgc gacagataat tttgaaaccc gcatgctgat 1330921 aaacgatctt gcccagaaaa caaagacacc ttgggtctat ggcgcctgtg taagcagcca 1330981 gggaatgttc atgactgtca ttcccggaga aaccccttgt ctgtcttgtt tgtttgagca 1331041 aattcctgtc ggcggggcga cgtgtgatac tgccggcatt attccgcctg ctgtgcatat 1331101 cgtttcagca tatcagcagg ctgaggcatt aaagctgtta accggccaaa aagaagcaat 1331161 acagcggggg tttgtgacat ttgatgtctg gaacaattcg catatgaaga ttaacgttaa 1331221 tcatgtacgc cgtgaggaat gcccatcttg cggagctaat gcggtatatc cttatcttca 1331281 ggattggaac acaccaaaag ctgctgtact atgcggccgt gatacagtgc aggtaaggtc 1331341 agaatcatta aaaagaatcc cgaaacagga gctcattaag cggctgaaaa caatcggcaa 1331401 ggtcgaggct aatgcgtttt tgctgcatat tttttacgag gatttcagaa ttgtcatttt 1331461 caatgacgga cgggcactgg tgcatggaac aaatgatgtg aaagaagcca actccgtgtt 1331521 ggcaagagtg attggactgt aacaacagga ggggtcagaa tgctggagaa aagaacaccg 1331581 ataccggtag acgaggcagt tcggcgtgtc tgccattttc aaaaacaagg tgaaacagaa 1331641 tgggtggcgc ttgaagacag ccttcatcgg tttttagccg aagatataac tgcggatcac 1331701 cacgtacctg cgtttgaccg ttcgccatac gatggttttg ctgtcagagc gtgcgatacg 1331761 gcagaagctt cacgtgaaaa cccagttcgg tttgaagtta ttgaccatat tggagcggga 1331821 gcagtatctg aaaaagaact tggcccgttt caggccgtgc ggattatgac tggcgcgcaa 1331881 atccctgaag gggcagatgc agtcgtcatg attgaactga ctcaagcctt tgaggagaat 1331941 gggaagtcat ttatgtcttt aaaacgccgc tttcagacgg gggataatat ttcaaaaaca 1332001 ggtgaggacg ctcaaaaagg gagtgtttta ctgacaaagg gcacccgggt gacaccagga 1332061 gtgacggctc ttttggcaac attcggatac gcatctgtgc ctgtcgtgag aaagcctgta 1332121 gtcgggatta tcgcaaccgg taccgaattg ctgaatgtca gtgatccgct ggaaccggga 1332181 aaaatccgca acagcaatgc gagtatggta tatgcgcaag cgatagaagc aggcgcaaca 1332241 ccgctttatt tagggaaaat ctctgatgaa ctggataaaa gctttgctgc agttaaagaa 1332301 gcgatgaaaa aggtggactt cctgatcaca actggcggtg tgtcagtcgg tgactttgac 1332361 tttttgcctg cgatctatga aaaactcgga gcggacgtgc tgtttaataa agttgccatg 1332421 cgcccgggca gcgtgacaac ggtggcgcat gcaaacgata tgctgctgtt tggcctttca 1332481 ggtaatccgt cggcatgcta tgtcggtttt gaactgtttg tcaaaccgat aatccagaca 1332541 tggctgctca atgaaacacc gcattcaatt tgtgcggaag ctgttttgac caaggatttt 1332601 ccgaagccga acccatttac ccgatttgtt cgtgcgctcg tgcaccatca ggaagggaag 1332661 ctgttggcga cacccgttgg cttagataag tcgagctctg tcacatcact tgcagatgcc 1332721 aatgcattta ttatcctgcc gggcggtacg cgaggctacg aatctggcag aacggttcaa 1332781 gtgctgctca tcagagaaga gaatggaagt gaatggcctt ggtccgtcct ttcccgatcg 1332841 tccaagttgt aggatttcaa aacagcggga aaacaacgtt tattgagcgc attcttgaaa 1332901 aagcctctga acagggagtc catttgggct gcctgaagca ccatggtcac ggcggtgaac 1332961 cgcaaacgct cacggaagga aaagacacgg accgttacaa ggcggcaggt gctgatgtaa 1333021 cagcggtaga aggtgctggt gtgttacagc tgactgcccg ccgcaattgg gatttggcac 1333081 ggctgattga gttataccaa tttctcgaaa cagactgtct tctgattgaa ggctttaaaa 1333141 aagcccctta tcctaaagtg gttatcctaa gtgaaaagga agatctggaa gcgctgcaag 1333201 cagtaaatat aatcgccatc atctatagaa aaaaagagca tatgacagag catcagggat 1333261 tacccgtttt tcatgcggat gatccggttg ccgtggattt tgtgctttca cagctgaagg 1333321 gggaatctgc ataatggaac ggtttgagat tacgaaaaca cccattaata ctgaaaacat 1333381 catcaaaaaa gtggagaaac gggaagcggg agccattaca acatttattg gtacggttcg 1333441 ggaatggaca aacggaaaaa gaacggttcg gcttgaatat gaggcatatg aaccgatggc 1333501 cgtgcaaatg cttgctcaaa tcggcgctga aatcgaagaa aaatgggaag gtgcctcagc 1333561 tgcgatcacg caccgtatag gtgtgctcga tatcggtgaa gcagcggtag tgattgctgt 1333621 atcttctccc catcgaaaag ccgcatatga agccaatgag tatgcgattg aacgcattaa 1333681 acagattgtg ccgatttgga aaaaagaaat ttgggaagac ggtgagcaat ggatcggcga 1333741 ccagctagaa acgacagctt atccgaacgg aaaaccagac ctaagcgagg gagagcagca 1333801 tgattaaaat tcttttattt gcagggcttg ctgaacaggc cggtacacaa gcaatagaaa 1333861 tagatatgga acaagcaacc acagatgaaa taaaagcgag tctaaaagaa caatacggtc 1333921 ttgaatctat tgatacggct atgattgccg ttaacgaaag ctatgtaaaa gaaaatacct 1333981 ctgtatcttc gggtgacacg gtagccatca taccgccggt cagcggggga tgaaaaccgg 1334041 acggcatttc agccgtccgg tttttctgta tttcattggc atatccccaa gtatcctcag 1334101 catacaatga ttttctgtaa gcgtttattc tacatatgtt actccctata aagtaagaga 1334161 ctcactccat aattagactg aaattttgaa aaataataga aatttatttc gggtatcgat 1334221 atagtgaaga tgataaatgt tggaaaggtg ctggatatgg agacatttaa aagattaaaa 1334281 atgtattatt ggccgtacag aaaagtgttt atgtggtcgc ttctagccat gcttttgatg 1334341 actgcaatta ctgtcgttta tccgattatc ctgcaaatta cgattgatga gatcgtactg 1334401 ggacggcagt atcagcttgc ggcgtgggtc agcttaggat ttattgcggt gatggttttg 1334461 aaaggaatgg ctaccttttt tcatcagtat ttaggtgata tgttcgggat caaatccgtt 1334521 tatcggctga gaaatggtct gtatgaaaaa ctgcagcggc tttctttttc ttactatgat 1334581 aacgcgaaaa caggagattt gatgtccagg ctgactgctg atgttgaagg gcttcgtttt 1334641 ttcttatcat acggtctcgc tgagctcatt cgcttcggcc tgctggtagc catcagcctg 1334701 tcggttatgt tttactattc tgttcctctc acgcttgtga caatagctgt tctgccattt 1334761 ctcgcggttg cggtataccg gtttgacaaa agagtccatc ccgccttcag aggcatccgc 1334821 aaatcgtttg cgaaactcaa tacaaaagtt caggaaaata tcagcggcat taatacggtt 1334881 aaatctcttt ccagggaaga ttttcagatc agcactttca ataaagccaa tgcagaatac 1334941 agggcgcagt atttacaaac atcatccatt tggtctgcgt atttcccttt aatggagttc 1335001 attggtaaca cttgtattgt agctcttctc tcatacggcg gttacttggt tatgcaaaat 1335061 cagctcaatc ccggcgagct tgttgctttc ttcagccttg tcaattatat gatgtggccc 1335121 attatgaact taggttttgt catcaatatg ttctctcaag caaaagcgtc aggggaacgc 1335181 ctgctcgaca ttctggaaaa agaagaagac attacagatc atcctcatgc tttgcataaa 1335241 caaaaattaa ccggagatgt ccatttcaaa aatgtttctc ttgcatacgg aaaagaacaa 1335301 acaaacgcgc tgtgcaatgt aagctttgag gcaaacagcg ggaaggtaat cggactgttg 1335361 ggcccgacag gttcaggcaa aagctcagtg acacagcttc tcaccagatt ttacagtcct 1335421 gttggcggaa tgattaccat tgatcacaaa cccatcacag attattcgtt aaaaaccctt 1335481 cgctccaata tcggggtcgt acttcaagaa tccttcctgt tttcatctac gattagatca 1335541 aatatttcgt atgggcggcc ggatgcctca atggaagacg tcatcgaagc ggcaaaaagg 1335601 gcgcaggctc ataactttat tatggagctt cctgatgggt atgacaccat gctgggagag 1335661 aggggaatgg ggctttccgg cgggcagaaa cagcgtattg ccattgcgag agccatctgc 1335721 ttgaacccga gcattttaat attggatgat gccacaagcg cagtagatat gcaaacggag 1335781 cacagcatac agcttgcctt aaaagaagtc atgaaaaacc gcacaacctt tatcgtcgct 1335841 caccgcattt cttcactgaa acacgctgat gaaattctcg tttttaataa aggacgcatt 1335901 cgtgaaaggg gaacacatca tgagcttctt gaaaaaggcg gctactataa aaagatttac 1335961 gatttgcaat accgtgatgt caaaatgatt aatgagccgc atgaggtcgg atagggaggg 1336021 gccaaatgaa acaagcgaaa aaacaggggg ttttagagcg tttctattac tcttcagatg 1336081 aaatcattga aaagccgttt aactgggctc aaatgtggcg gctgctgagc tatgtcaaac 1336141 catatcgaaa aacaattttg ccgctttctt ttctcactgt attgattggc actgctgtga 1336201 agcttgtgat ccccattttg atcggcgttt atgttcttga tcaagcgatt acagggagaa 1336261 actcggagct gctgattcag ctcattttta ttattagcgg tttatatgtc ctcaattacg 1336321 ccgccaatgt gttaagaatc aggtggatga atcagcttgg ccagcatgtc atttacgatt 1336381 tgcgacagca tttatttacc catgtgcagc gcttatccca tcgatttttt gatcagcggt 1336441 cggcgggatc gatcttagtc aggatcatga atgatattaa ctctcttcag gagctcttta 1336501 caagcggagt catcaatttg ttgaccgact tgctgcttct ggccggcgtg attattattt 1336561 tgtttacgct gagccctgag ctgactatag ccatcatggt gacattgccg attatgtttt 1336621 ttatttcaac aagtctcaga aaaaaaatac gccgatcctg gcaaacggta cggctgaagc 1336681 aatcgaagct caactctcat ctaaacgaaa gcattcaggg catccgggtc acgcaggcat 1336741 ttacgcagga agaagaaaac atggcgtatt ttgacggtgt caatcaggag aactacgaat 1336801 catggcggga agcaactaga aaaaatgcca tgttccgtcc gcttgtagaa atgacgaatg 1336861 cgattgggac ggctgtcttg atttggtatg gagccacact catcatgaat gaaaccatta 1336921 cgattggcgt cttcgtttct tttgctttct atctgggaat gttttgggaa cctatttcga 1336981 gactgggtca ggtctataat cagctgttaa tggggatggc atcatcagaa cggatttttg 1337041 agtttctgga cgaacagcca aatgtcaagg agaagccgaa tgccattcat aatgaaaaga 1337101 taaatgggga gatcagtttt gaagaggttg aattttcgta tgatgaaaaa cgaaaagccc 1337161 ttcacgccgt ttctttctct attcctgcgg gatcgacgct tgcgcttgtc gggcatacag 1337221 ggagcgggaa gacgacgatt gccaatttaa tcagccgttt ttatgatgcg gccggaggca 1337281 ccattaaaat agacggtata ccgattaagg atctttccct tgccagtctg cgctctcaaa 1337341 tcagcattgt cctgcaagat acatttattt tctccgggac catcatggaa aatattcgtt 1337401 ttggaaggcc aaatgcttcg gatgaagagg tgatgaaagc gtcccaagcg gtcggagcgg 1337461 atgagtttat ttccgattta gcggaaggat acgcaacaga ggtagaggaa aggggcagcg 1337521 tactgtctgc cggtcagcgc cagctcattt catttgcaag agcattgctc gccgatccgg 1337581 ctattatcat ccttgacgaa gcaacggcaa gcattgatac agagacagaa gtaaaaattc 1337641 agcaagcgtt aaaaacgctt ctgaaagggc gtacagcagt gatgatcgct cacagattgt 1337701 ctacgatccg cgacgccgac cgcatcattg ttcttgatca cggcaggaaa atagaagaag 1337761 ggaaccatga tcagctgctc gctaaaggag gcatttatgc cgggcttgtg aaagcgcaat 1337821 acagcacagc gatagaataa tatgaaaagc cttcaatatt gaaggttttt ggaaatttat 1337881 tagaaaaaca tgaaactttt tgatatcctt cccgtactat ttgttagata ttctcaagga 1337941 ggttttgaaa tggaaacgaa tgtagaaaaa aacagcggaa cggcgactga aaagccttca 1338001 cttttcggag taatcacaag tccgtccgtt caatttgaaa gaataagaga aaggccggct 1338061 gtatggggac cgcttttgat tgttgcagca attatcatcg tcggtgccgt gctgcaatca 1338121 ctcggtacgg attatagtga gcttttgaaa agccaggata cgcaagggct atctgctgaa 1338181 caaatggaaa ctgtcgcaac aataaccaaa tttggcggaa tggcaggcgc tattatcggc 1338241 ggtatcgcag cattatttat tgcccctctt atttattggc tctgtgtaaa agtatcaggc 1338301 ggtgttacga catataaaaa aatgctttct ctcagtctgt ttgtctcttt gattagcagt 1338361 ctcggattat tggttaatgg aatcgttgct tttacgactg acgtgaatcc tctttacagc 1338421 acgacgtcac tcgcagggat tatcccatct gacggggctc tcgccagtgt gttaaatacc 1338481 tttgaaattt tcagcatctg gagctttgta ttattagcaa tcggacttca caaaacggga 1338541 ggcatctcaa aaaaagccgg gtggatttca gcaatcattc tattcggaat tttagttgta 1338601 ttttcgcttt tttcaggttt aatcaattct gtggcgggtg cataagctca tgaaaaaagt 1338661 ctggatcgga attggaatcg cagttatagt cgctcttttt gttggaatca atatataccg 1338721 gtctgccgct ccgacaagcg gcagcgccgg caaggaggta cagacgggga gcgttgaaga 1338781 aaatgaaatc tcatcaacgg ttatggttcc tggcacgcta aaattttcaa atgaacagta 1338841 tgtcttttat gaagcggata aagggacatt agaagacatt aaagtaaagg aaggcgataa 1338901 agttaaaaag ggcacggctt tagtcaccta tacaaatgag cagctgagcc tggaaaaaga 1338961 acagaaccag ttaacgtctg aatccaaccg gcttcaaatt gaccaaattc aagaaaagtt 1339021 aaaagccttg gacagcaaag aaagagaact ggaaaaacag gtaggaaaga aagaagcaga 1339081 aaaacaaatc gaatctgaac ggacagagct tcaaatgcag aaaaaaacag cggagatcga 1339141 attaaaacaa accgagcttc agcggcagtc acttgccaac cgggtgtcag atttagaagt 1339201 gaaaagcgaa attgaaggca ccgttatttc tgtcaaccaa gaagcggcat ccaaaaagtc 1339261 agatattcaa gagcctgtca tacatatcgg caacccaaaa gaccttgtcg tctcagggaa 1339321 attgtctgaa tacgatacat tgaaagtcaa aaaaggccag aaggtcacac tcacttcaga 1339381 tgtaatacag ggtaaaacat ggaaaggcac ggtttccgca gtcgggcttg ttccggatca 1339441 gcaggagagc gctgcggcac aaggaacaga acaggcggtc caatacccgc ttcaagtgaa 1339501 aataaaagga aatcttccag aaggaaagcc aggctttaaa tttatcatga atattgaaac 1339561 agataaacgg aaagcaaata cgcttccttc aaaggcagtc aaaaaagaag atgaccaata 1339621 ttatgtgtat acagtaaaag acggaaaagc aaagcgagtt gatgtcaaaa tcggcgaagt 1339681 gacagatgac ctgacagaaa ttaaagaggg gcttacccaa gatgatcaag tcattttgaa 1339741 tccatctgat caggtgactg acggaatgga agtgaaatcc taaatgattc agctttctaa 1339801 tgtgcgaaaa agctaccaga tcggaaagga aacgtttgat gttctccatt ctattgattt 1339861 ggacattcat caaggtgaat atgtctcgat tatggggccg tcaggatcag gaaaatcgac 1339921 gatcatgaat attatcggct gtcttgatcg gccgacttcc ggtacatatc aattggacgg 1339981 cgaagacatt tcttcatata aagataaaga actggcggca gtccgtaacc ggtccatcgg 1340041 ttttgtattt cagcaatttc agcttcttcc gcggctgaac gcaaaaaaaa atgtcgagct 1340101 gccgatgatt tattccggga taggcaaaaa ggaacgtcaa gagcgggctg agagagcatt 1340161 ggaaaaggtc gggttagccg atcgaatgct ccacatgccc aacgagctgt cgggcgggca 1340221 gaagcagcgg gtggcgattg cgagggcgat cgtgaatgag ccgaaattga ttttagctga 1340281 tgaaccgacc ggcgcgctgg atacgaaaac aagcgaggcg attatggatc agtttacagc 1340341 attaaatgcc gagggaacga caatcgttct ggttactcac gagcctgaag tagcagattg 1340401 cacgaatcgg atcgtcatgg tgcgtgacgg aaacattgtt cctgccagct ccggacaaag 1340461 gagtgtggga gaatgagcct gttggaaaac atcagaatgg ctctaagctc tgtccttgcc 1340521 cataaaatgc gttcgatctt aacgatgctc ggcattatca ttggtgtagg ctctgtcatt 1340581 gttgtcgttg cggtaggaca gggcggcgag caaatgctga agcagtcgat cagcggcccg 1340641 ggaaatactg tggagctgta ctatatgcct agcgacgagg agcttgcaag caacccgaat 1340701 gccgcagctg aatctacgtt tacagaaaac gatattaaag gtttaaaagg aatagaaggc 1340761 attaaacaag tcgttgcttc gacttctgaa agtatgaaag cgcgttatca cgaagaagaa 1340821 accgatgcta cggttaacgg aataaatgat ggatacatga atgtcaattc tttgaaaatc 1340881 gaaagcggca gaacctttac cgacaatgac tttctcgcgg ggaatagagt cggaatcatc 1340941 tctcaaaaaa tggctaaaga gctgtttgat aaaacctccc ctctaggtga agttgtctgg 1341001 attaacggac agcccgttga aattatcggc gtgctgaaaa aagtaacagg cttgctttct 1341061 ttcgatttaa gtgaaatgta tgtgccattt aatatgatga aatcctcttt tggcacaagt 1341121 gatttcagta acgtatcatt gcaggtcgaa tcagcagacg acataaaatc ggctggaaaa 1341181 gaagcggcac agctggtaaa tgacaatcat ggcacagagg attcgtatca agtgatgaac 1341241 atggaagaga ttgcggccgg aattggcaaa gtaactgcaa ttatgacgac gattatcggc 1341301 tcaattgcag gtatttccct tttggtcggc ggaatcggtg tcatgaatat tatgctcgta 1341361 tcagtcacag aacggacgcg ggaaatcgga atcagaaaat cacttggtgc gacgagggga 1341421 cagattctga ctcagttttt aattgaatca gtcgtattga cgctgattgg cggtctggtc 1341481 gggattggta ttggatacgg aggggccgcg cttgtttcag ccattgcggg ctggccgtca 1341541 ctcatatcct ggcaggttgt atgcgggggc gtgctgttca gtatgctcat tggtgttatt 1341601 ttcggcatgc ttcctgcaaa taaagccgca aagcttgatc ccattgaagc gctgcgttat 1341661 gagtagcctc atgcaacatg catgaggttt ttttatgttt agtgatttct actatgaata 1341721 taaaagactt ttttcattaa aataagaaga aaatgtcgta caattgtcct tatttttgtc 1341781 gaatttacag tttacaaacc ctatagacat acgttaatat ggagaaacgt gaaagatttt 1341841 gatagttatt gaatgaattt gaatgatttt agttgcctaa accgaaaata gcgtttacaa 1341901 tgaaattgta ttcaaaatga atacgttttc attaggaggt gaagcatgct aactcctgaa 1341961 cggcatcaat tgattattga tcaaatagaa aagcatgatg tggtaaagat tcaagagctt 1342021 ataaatctga ctaatgcttc tgaatcaaca atcagaagag atttatcgac ccttgaagaa 1342081 cgcggttttt taaagcgcgt tcatggtgga gcggccaagc tttccgatat cagacttgaa 1342141 cccgatatgc ttgaaaaatc atccaaaaac cttcacgata aactgaagat tgctgaaaaa 1342201 gctgcttctc ttttagaaga aggggattgc atttaccttg atgcaggcac gacgacattg 1342261 cacatgattg attttatgga taaaaccaaa gatattgtcg ttgtcacaaa cggggtaatg 1342321 catatcgatg cattaataag gaaagaaatt tctttttatc tgcttggagg atacgtaaag 1342381 cacagaacgg gcgcgattat tggaggcgct tcattggttg ccatggacca gtacagattt 1342441 gacaagagtt ttctggggac aaacggtgtc catacagagg ctggatttac aacgccggac 1342501 cctgatgagg cccttttaaa acagaaagcg atcaaacagg caaaacacgc ttacgtctta 1342561 gcagaccctt cgaagttcgg agaaatttca ttttcggcat tcgccggaat aggcgacgca 1342621 acaatcatta cgactgacgc tgaagagctt acattcgata attaccaaga aaaaactgtc 1342681 gtaaaggtag tgaaaccatg atttacactg taacacttaa tccatctgtc gattatatag 1342741 ttcacgttga agattttact gtaggaggcc tgaaccgttc ttcgtatgat accaagtatc 1342801 cagggggcaa aggcatcaac gtatcgagac tgctgaaaag acaccatgtg gcgtctaaag 1342861 cgctcggatt cgtcggcgga tttaccggag aatatatcaa aacattttta cgggaagaaa 1342921 acctggaaac agctttttct gaagtaaaag gggatacccg tatcaatgta aagctgaaaa 1342981 cgggtgatga aactgaaatt aacgggcagg gaccgacaat ttcggatgaa gatttcaaag 1343041 cctttttaga acagttccaa tctttgcaag agggagatat cgttgttctt gcaggaagca 1343101 ttccatcttc actccctcac gatacttatg aaaaaatcgc agaggcctgc aaacagcaga 1343161 acgcacgagt tgttctggat atctcaggcg aggctctttt gaaagcaaca gaaatgaaac 1343221 catttttgat gaagccaaat catcatgagc ttggagaaat gttcggcacg gccattacat 1343281 ctgttgagga agccgttcct tatgggaaaa agcttgtaga acaaggcgct gaacatgtaa 1343341 tcgtatcaat ggccggagac ggagcgcttc tgtttacgaa cgaagctgtt tattttgcta 1343401 acgtgccaaa ggggaaattg gtaaactcag tcggagcagg ggattccgtt gttgcaggtt 1343461 tccttgccgg aatttccaaa cagctgccgc ttgaagaagc attccgctta ggagttactt 1343521 caggcagtgc taccgcgttc tctgaagaac ttggaacaga agaatttgtc cagcagcttc 1343581 ttcctgaagt taaggtcaca cgtctataga ggaggaaaca caagtgaaaa taactgagct 1343641 tttaacgaag catacgataa agcttaatat tgagagcaaa gaaaaagaaa atgttattga 1343701 cgaaatggtc actgttcttg ataaggctgg aaagttaaat gaccgacaag cctataaaga 1343761 agccatttta aatcgcgaaa gccaaagctc cacgggtatc ggtgaaggaa tcgctatccc 1343821 ccatgcgaaa acggcaagcg ttatcaaccc ggcgatcgcg ttcggacgtt caaaagacgg 1343881 cgtcgattat gaatcattag acggccagcc ggctcactta gtgttcatga tcgcggcgac 1343941 tgaaggcgca aacaacactc accttgaagc attgtcaaga ctttcaacgc tgttaatgcg 1344001 tgaagaaatc cgtaagcagc tccttgaagc tgagtctgaa gatgccatca tcgacattat 1344061 taatcagcac gataaagatg atgacgaaga ggaagaggaa gaagaagcgg caccagcacc 1344121 tgccggaaaa gggaaaattt tagcggttac tgcatgcccg acaggtattg cccatacatt 1344181 catggctgcg gatgccctta aagaaaaagc gaaagagctt ggtgtggaaa ttaaggtcga 1344241 aacaaatggg tcaagcggca ttaagcacaa gctcactgcc caagaaatcg aagatgcacc 1344301 tgcaatcatt gtcgcagcgg acaagcaggt tgaaatggaa cgttttaaag gcaagcgcgt 1344361 acttcaagtt cctgtaacgg cgggtatcag acgtccgcaa gagcttatcg aaaaagcgat 1344421 gaatcaagat gcgccgattt atcaaggcag cggcggcggt tcagcagctt caaatgatga 1344481 tgaagaagcg aaaggcaagt ctggaagcgg tatcggaaac acgttttata agcacctgat 1344541 gagcggtgtc agcaacatgc ttccgttcgt agtcggcggc ggtattctcg ttgcgatttc 1344601 attcttctgg ggaattcact ctgctgatcc gaatgatcct agctacaaca cgtttgcagc 1344661 agcattaaac tttatcggcg gcgacaatgc attaaaactc attgttgcag ttctggccgg 1344721 tttcattgcg atgagtattg cagatcgtcc tggttttgcg cctggtatgg tcggcggatt 1344781 tatggcaact caagcgaatg ctggattctt aggcggctta attgccggat tccttgccgg 1344841 ttatgtcgtg attttactga aaaaagtatt tacgtttatc cctcagtcac ttgatggatt 1344901 aaaacctgtt ttgatttacc cgctgttcgg tatttttatc actggcgtat taatgcaatt 1344961 tgtcgtcaat acacctgtag cggcatttat gaatttctta acaaactggc ttgaaagcct 1345021 tggtactgga aaccttgtgt taatgggtat tatcttgggc ggcatgatgg cgatcgatat 1345081 gggcggtccg cttaataaag cagcctttac gttcggtatc gccatgatcg atgcaggcaa 1345141 ctatgcgcct catgcagcaa tcatggccgg cggtatggtt cctccgcttg gtatcgcact 1345201 tgcaacaacc attttcagaa acaaattcac tcagcgtgac cgtgaagctg gtattacatg 1345261 ctatttcatg ggagctgctt tcgtaacaga gggagcgatc ccatttgctg cggctgatcc 1345321 gcttcgcgtc ataccagctg ctgtagtcgg tgcagctgtt gccggcggat taactgaatt 1345381 cttccgagta acgcttccgg cgcctcatgg aggagtattc gtagctttca ttacaaacca 1345441 tccgatgctt taccttttaa gtatcgtgat cggtgctgtc gtgatggcaa ttatcctcgg 1345501 tatcgtcaaa aaacctgtta cagaaaaata agaaaaaaag cgtccttggt tcgaaaggac 1345561 gctttttctt atccggccgg cagggagcgc ggttaagtta tgtattttat tcttttttat 1345621 gataaagtaa aagaagagaa acaactgaca tagcaattgt ctaggaggaa acactttgac 1345681 cgaggaaaaa aatacgaata ctgagaaaac ggcgaagaaa aaaaccaata cgtacctgga 1345741 atggggtaaa gcgattgtca tcgctgttct gctggctctc ctgatccgtc actttttgtt 1345801 tgaaccgtat ttagttgaag gttcatctat gtatcccaca ttacatgacg gagaaaggct 1345861 gtttgtgaat aaaacagtca actatatcgg cgagctgaag cgcggagata tcgttattat 1345921 caacggtgaa acttctaaaa tccattatgt aaaaagattg atcggaaagc ctggagaaac 1345981 cgttcaaatg aaggatgaca cgctttatat aaacggtaaa aaagtagccg agccttactt 1346041 gtctaaaaac aagaaggaag cagaaaaact tggtgtcagt ctgacaggag actttggacc 1346101 ggttaaggtt ccgaaaggca aatactttgt catgggagat aaccggctga attctatgga 1346161 cagccgaaac gggctgggac tgatcgcgga agatcgaatt gtcggcacat cgaagtttgt 1346221 ctttttcccg tttaacgaaa tgcgtcaaac aaaataaaaa cgccttgctg gcctaggaca 1346281 gcaggcgttt ttattttgaa aaagaagcga ccaatgcaat gcataaaacc gtgatgaaca 1346341 ctgaaccgat aatagccagc acactgaaga aaaggtgaac ctgtttgttc tcttttccgc 1346401 gcttttctaa tagccgttta gaaaaaatgt gcgaaaatat gtaaataagg gctatgccta 1346461 tatataagcc gatatctttg gcggtaaagc ctgttacggc aaggtaaaag cccgtaaaaa 1346521 agatcagtaa gcaatattca gtaagtgtta aaagcctcaa cgtgttcctc catgagagtg 1346581 tgtaattttc caggcggatg cattctctct ctttaattgt aacacagctg gctggtttgg 1346641 gtgtataagt gttttctctc tgttttatca gggaatcatt tctcttgccc tgcattcatg 1346701 gtatactttt attgatgata gacatgatgg aggataataa atgattgctg taaataatgt 1346761 aagcttgcgg tttgcggatc gcaagttatt tgaagatgtt aatattaaat ttaccccagg 1346821 caactgctat gggttaattg gtgcaaacgg tgccggtaaa tcaacgtttc taaaggtgct 1346881 gtcaggcgaa atcgagcctc agacaggcga cgtgcatatg agtcctggcg agcgtcttgc 1346941 cgtcttgaag cagaaccatt ttgagtacga agagtatgaa gtgctgaaag tggtcattat 1347001 gggccacaaa cgcctgtatg aagtcatgca ggagaaagac gctatttaca tgaagcctga 1347061 tttctcagat gaggatggga ttcgtgctgc tgagctagaa ggtgaattcg cggaactgaa 1347121 cggttgggaa gcggaaagtg aagctgcgat cctgttaaaa ggccttggta tctcagaaga 1347181 tctgcacaca aaaaagatgg cagacctcgg cggttcggag aaggtaaaag ttctcttggc 1347241 acaggcatta ttcggcaagc cggatgttct gctgctcgat gagccgacga accacctgga 1347301 ccttcaggca attcagtggc ttgaagagtt tctgattaac tttgaaaaca cagttattgt 1347361 cgtatcccat gaccgtcact ttttaaataa agtatgtacg cacattgccg accttgattt 1347421 taacaaaatt caaatctatg tcggaaacta tgatttctgg tacgagtcaa gccagctggc 1347481 gttaaagctt tctcaagaag cgaacaagaa aaaagaagag cagattaaac agcttcaaga 1347541 gtttgtcgct agattcagcg ccaatgcgtc taaatctaag caggctacat caagaaagaa 1347601 acttctcgaa aaaatcacgc tggatgatat taaaccgtct tcccgccgct atccttatgt 1347661 taacttcacg ccggaacggg aaatcggaaa tgatgttctt cgcgtggaag gcttaacaaa 1347721 aacaatcgat ggcgtaaagg tgcttgacaa tgtcagcttt attatgaatc gagaagataa 1347781 aattgctttc actggccgaa atgaacttgc tgttactacg ctgtttaaaa tcatttccgg 1347841 ggaaatggaa gctgacagcg gaacgtttaa atggggtgtt accacatctc aagcgtattt 1347901 tccaaaagac aacagcgaat atttcgaagg cagtgatctg aaccttgtag actggcttcg 1347961 ccaatattct ccgcacgacc aaagtgagag ctttttacgc ggtttcttag gacgcatgct 1348021 gttctctgga gaagaagtcc acaaaaaagc aaatgtactt tccgggggag aaaaggtccg 1348081 ctgtatgctg tcgaaagcga tgctttctgg cgccaatatt ttaattttgg atgagccgac 1348141 caaccattta gacctagagt ccattacagc gctcaataac ggcttaatca gctttaaagg 1348201 cgctatgctg tttacttccc atgaccatca gtttgtgcag accattgcca acagaattat 1348261 agaaattaca cctaacggca tcgtcgataa gcaaatgagc tatgacgagt tccttgaaaa 1348321 tgctgatgtg cagaaaaaat tgactgaact atacgccgaa taaaaaagca gagatttctc 1348381 tgcttttttt gatacctaaa tgtgaaagga gatcacaaca tgaaattttt ggttgtcgga 1348441 gcaggtggag taggcgggta tattggcgga cggctttcgg agaaaggaaa tgatgtgaca 1348501 tttctcgtgc gccaaaaacg agctgagcag cttaaaaaaa ccgggcttgt catccatagt 1348561 gaaaaaggga atgtatcatt tcagcccgaa ctaatcagtg ccggagaaac agggcaattt 1348621 gatgtcgtta tcattgcttc taaagcatac tcgcttggtc aagtgataga ggatgtcaaa 1348681 ccatttatcc atcaagaatc tgtcattatc ccttttttaa atgggtaccg ccactatgag 1348741 cagctatttg cggcattttc aaaagaacag gtgctgggcg gcctgtgttt tatagaaagt 1348801 gctttagaca acaaaggaga aattcatcat acgagcgcat cgcatcgttt tgtatttgga 1348861 gaatggaacg gcgagcgtac ggagcggata agagcgcttg aagaggcatt ttcaggtgtg 1348921 aaggctgaag tcatcattag cgggcatatc gagaaggaca tttggaaaaa gtatctcttt 1348981 attgcagcgc aagcggggat cacaacgtta tttcaacgac cgcttggccc aatcctcgcc 1349041 acagaagccg gacgtcacac ggcccaaact cttattgggg aaatttgcac tgttttacga 1349101 aaagaaggtg ttccggctga tccggctctt gaggaagaga gctttcgtac gatgaccagc 1349161 atgtcttacc atatgaagtc ctccatgctt cgggatatgg aaaacggcca aacgacagaa 1349221 ggcgaccacc tgcatggatt tttgattgaa aaagcaaaac gtttatctct cgctgcacca 1349281 gtattagaaa ccgtttatgc gaatctgcaa atgtatgaag cagaaaaata aaaaaaggag 1349341 gcggaaaagc ctccttttat ttacttaaaa agcccaattt ccgtttctga agataggctc 1349401 tcttttcccg tctgccgtaa ttccgtcaat attcatatcc ttagaaccga tcataaagtc 1349461 cacgtgtgta atgctttcat ttaggccttc tttgacaagc tcttcacgag acatctgctt 1349521 tccgccttca atattaaagg cataggcgct tccgatcgcc aaatgatttg acgcgttttc 1349581 atcaaacagc gtgttataga aaagaatgtt tgattgtgat ataggcgaat cgtaaggaac 1349641 aagtgccact tcacctaaat agtgagaacc ttcatctgtt tccaccagtt cttttaaaat 1349701 atcctcacct ttttcagctt taatgtcgac tatacggcca ttttcaaacg tcagggtgaa 1349761 attttcaata atatttccgc cgtagcttaa tggttttgtg cttgatacca ctccgtcaac 1349821 cccgtctttt tgcggcagcg tgaacacttc ttctgtcggc atattggcca taaactcatg 1349881 gccactttca ttcacgcttc ccgcacctgc ccaaacatgc ttcctaggca gcttaattgt 1349941 tagatcagtt ccttctgctt gataatgtaa ggcagcgtaa tgtctctcgt tcaaatggtc 1350001 aactttttca tgaagatttt ggtcatgatt gatccacgcc tgaaccgggt tgtcttcatt 1350061 tacgcgcgtc gctttaaaaa tttcttccca cagaaggtgg atcgcttcct cctctgattt 1350121 gccaggaaac accttgtgag cccagcctgc tgatgccgca cctacgacag tccagctgac 1350181 tttgtctgat tgaatatatt gtctgtatgt atgtaatgct ttgcctgctg ctttttggaa 1350241 tgccgcaatc cgtttggaat ctataccttt tagcaagtct gggttcgacg acacaacaga 1350301 aatgaaagca gctccatttt tggcaagctc ttctctgcct tttgcttccc attcaggata 1350361 ttcttcaaat gcttcaaacg gcgcaagttc gtattttaat ttggcgactt cgtcatcctg 1350421 ccaattcacg gtgacgtttt ttgcgccctt ttcatatgcg tgttttacaa ttaaacggac 1350481 aaaatcccga acgtctgttg aagcatttac gactacatac tggccttttt ggacattaac 1350541 gccgacttct accgccagct gtgcatatgt atttaatttc tgtgaaaatg aatccatgaa 1350601 tcattcctcc aagctttttt ctcatcatat caaatatgat cctataaagg aaagaaggag 1350661 cccaaagtga aaaacccaaa acgacacgtc ttgggttttt tcaatattat ggatgattca 1350721 gttttacagt gccgcctgca ggcgaatggg gcatatttgc caaagaaatg ctcatgcctc 1350781 caagaataat tccgcttaaa atggctgcga tcgctactct tcttcctaaa tctcttagca 1350841 tctgtttcct ccttaacgtt tctccatttc ccacaatatg aaggaagtga ggaaaaaaga 1350901 agcaagaaat ttgccgcgtg tgagaatttt gcgggtaaag actatttaat tgccttttgc 1350961 agcttatcaa tcacttctaa agaacggcct gtgccgattg ctacagattc aagcgggttt 1351021 tgcgccacgt gtacaggcac gacaatctct tctgtgagcc attctttaat tccattaagg 1351081 agcgcgccgc cgcctgttaa aataacgccg cgatcaacaa tatctccgct caattcaggc 1351141 ggacagtcct caagtgtcgc tctgatggct tcaagaatat gcaggaggga ttcacgcatt 1351201 gcatcttgaa tttcgttgga ttgaagcata atggtttttg gaagacctgt cacgaggtca 1351261 cgtccccgaa tttccattgc ctctggtata tgttcaatca gagcatggcc aatttccatt 1351321 tttacctgct cagctgtgcg ttcgccgatc agcaaattgt attttttacg gacgaaagaa 1351381 acgatatcct catcaagctg gtctccgccg atcctgatag aatggcagga aacaacgcca 1351441 ccgaaggaaa taatagcgac ctctgtcgtc cctccgccga tatctactac cacattggca 1351501 accggctcat caaccggtaa atccgctccg atggcggctg caactggctc ttcgattaaa 1351561 tgaacgtttt tcgcgccgca atttttcacc gcatcactga tggcgcggcg ttctactgct 1351621 gttgagcctg atggtgtgca aacgactacg ttcggttttc tgaacgacat gccgatgctt 1351681 tttgcggctt ttttcataat gtgctttagc aggtcagttg tcatatcata gtctgcgatc 1351741 acgccatctt tcatcggtct gacagcgaca atttttcccg gtgttttacc gatcatgttt 1351801 ttcgcgtcag ctccgattgc aagcactgct tttgtcgtcg tatccactgc gacaacagat 1351861 ggttcattta ggataatccc tttatttttg ctgtaaacaa gtatattagc tgttcctaag 1351921 tcaatcccga tttcagttga ttgaaacatg ttttcaccca atctctatcc taatttaata 1351981 tgattctaca tttaaagttt ctcagaaata ctgcgatttt tgggggtgtg cgtcggtaaa 1352041 gaaatgtttt tgtaaaaaat caaggaactg tgtaacagaa gtaatacatt tttcggtttt 1352101 atggaaaaaa tatcttgtaa ttcttataga aagcgggaaa ctttttcaaa gtttcattcg 1352161 tctacgatat attgaggtac atccttaaaa cattacatga gaaaagaaac atttaaagga 1352221 agaagggttt ttatgaaatc aataggtgtt gtgagaaaag tagatgaatt aggccgcatt 1352281 gtcatgccga ttgagttgag acgggcattg gatattgcca taaaagacag cattgagttt 1352341 tttgttgacg gagataaaat tatcttgaaa aagtacaaac ctcatggcgt ttgtttaatg 1352401 actggagaaa tcacttcaga aaataaagaa tacggcaacg gtaaaattac gctaagccct 1352461 gagggtgcac agctgcttct cgaagaaatt caagccgctt taaaagaata aaattatgct 1352521 aaaaaaggcg gagtgatatc atctccgcct tttttgcgtg ccaatttttg attaccgccg 1352581 cctaagataa gacatcaaga tatttggtaa tgaatgattt gggatacttt acatatttta 1352641 ctcaattatt tgtcgaagaa tggtacaata agtagagaaa cacaagcggc aggtggtcat 1352701 atgagaaaat atcaagctcg tatcatttcc atcattttgg caatgatttt tataatgttt 1352761 tgggattatt tattttattt tataggcaaa aacccgatta attggcctgt tgatattgtg 1352821 tatactgcag tcacgctggt aagtgtctgg atgttggctt attatattga tgagaaacag 1352881 cagctggtta agaaaatgaa ggataacgaa tggaagtata aacagctttc tgaagaaaaa 1352941 aaccgcatca tggataattt gcaggaaatc gtatttcaaa cgaatgcaaa aggtgaaatt 1353001 acatatttaa accaagcgtg ggcatctata accgggtttt caatcagtga atgtatggga 1353061 acaatgtata acgattactt cataaaagaa aagcacgtag ccgaccacat taacacccaa 1353121 atccaaaaca aagcgtcttc tggcatgttt acggcaaaat acgtgacaaa aaacggcacg 1353181 attttttggg gagaagttca ttataaactt tactatgacc gggatgacca atttacaggc 1353241 agcctgggta caatgtcaga tatcactgag cggaaagagg ctgaagatga gctcattgag 1353301 attaatgaac ggctggcgag ggaatcccag aaactatcaa tcacaagtga acttgccgca 1353361 ggtattgctc atgaggtcag aaacccttta acatctgtca gcggtttcct ccagattatg 1353421 aaaacacaat atccggacag aaaagactat tttgacatca tcttttcaga gattaaaaga 1353481 atcgatttag tgctcagcga gctgctgctg cttgcaaaac cgcaggcaat cacatttaaa 1353541 acacaccagc ttaatgagat cttgaaacaa gtcacgacat tgcttgatac caatgcaatt 1353601 ctgtccaata tcgtcataga gaaaaatttc aaagagacag atggctgtat gattaatgga 1353661 gacgaaaatc agctgaagca ggtctttatc aacatcatta aaaacggaat tgaggcaatg 1353721 ccaaagggcg gtgtcgtaac catttcaact gctaaaaccg cctctcatgc agtgataagc 1353781 gtaaaggatg aaggaaacgg catgccgcag gaaaagctga agcagattgg caaacctttt 1353841 tattcaacaa aagaaaaggg cactggactg ggacttccca tttgtttgag aatcctgaag 1353901 gaacatgacg gggaattgaa aatcgaaagt gaagctggaa aaggcagcgt ctttcaagtg 1353961 gttttgcctt taaaatcaga cagctgagag gagaaaaata aagtgaactc gcttctgttt 1354021 gtatacggga cattaagaaa gcatgaaaaa aaccatcatt tgctggcaca atcggcatgt 1354081 atcaatgagc aggcgagaac aaagggaagt ttgtttgctg caaaagaggg gcccacagtt 1354141 gttttcaatg atgaagatga aggctatata tatggcgaag tatatgaagc agatgaattg 1354201 tgtatacata agctcgatca attttttcaa ggatatcata aacaaacggt gtttgtagaa 1354261 acggatgtcg ggattaaaat tgcgcttatt tattttatga acaaagacgg gtgtgccggt 1354321 tttacgaaaa taagcagcgg cgactggaaa gaacatcaga tgatcagcaa atcgaaaaat 1354381 cccatttatt attttgccta tggatcatgc atggataatg cccgctttca aaaagcggga 1354441 gtcgatcact attttcaaga tccagtagga agagctgttt taaaaggata cacaacccgc 1354501 ttcacgctaa aaagggaaga cggttcaaga gcggacatgt tggaagacgg aggaacaaca 1354561 gaaggcgttt tataccgtat cccttattct gctctctcct atctatataa aagggagggc 1354621 gtcgaatctc ttacgtatcg gccggcattt gtagacgttg aagctggcgg aaggcactac 1354681 aaagactgtt taacctttct cgtcctccaa aaagaagcgg aaattgcccc gcctcagcac 1354741 tatcagattg aaatcgaacg cggagcggag ctgtatttgt cgcctgagtt tactgaaaag 1354801 ctcaagcggc atatgaattc gctgccaaaa ggataacact gtaacaaaag aatatgataa 1354861 aatttgatca atatcatgtc atataaagga gcaccacgat gaaaaaagaa tttgcggtaa 1354921 ttgggctggg ccgttttggt ggcagtattt gcaaagcatt aagcgaagaa ggcgtcgagg 1354981 ttatggcaat ggatatcgat gaagataaag tcaacgagta tgccaagatt gcatctcacg 1355041 cagttatcgg tgattcgaca gacgaatctg tcctgaaaaa tttaggcctg cgaaattttg 1355101 accacgttat tgtagcaatc ggggaaaata ttcaagcgag tattttaacg acactcattc 1355161 tgaaagaact tggcgtccat acgattacag ttaaagcgca gaacgattat cacgaaaaag 1355221 tgctgtctaa aattggtgcg gatcacatcg tccacccgga acgcgatatg gcaaaacgaa 1355281 ttgcgcataa tatcgtgtcc aacaatgtac ttgactattt ggagctgtct gaagagcata 1355341 gtcttgttga aatcgtagct aacagccgcc tggctggaaa tacgcttctc gatttagata 1355401 ttcgcgcaaa atacggtatt aacatcgtag ccataaaaag gggcaaggaa gtcatcgtat 1355461 caccgcttgc aaccgaagtc atccaccaag aagatatact cattgttatt ggatcagtta 1355521 cagacatctc ccgtttcgaa aaaagagttc ttcatacaaa atagcagcca aataagccgt 1355581 cctcaaaggg cggtttttca tattatcaga atataacaac tttaatgaac tgagcgtcaa 1355641 tttcttaaaa tttcattgac taagcacagg cgttccgata gcatattgta ccatataata 1355701 aaaaaaggag gggcctattt gaataaagaa gcgctagtca ataggctgaa tgcttcagcc 1355761 aaaagacaaa aagctgatat cgtcattaaa aacggaaaaa tcatggacgt atataatcaa 1355821 gaatggatat atgaagatat tgcgattaca gatggagtta ttgtaggcct cggtgagtat 1355881 gaaggcgaaa atatcattga tgcagaggga caaatgattg ttccgggttt tattgatgga 1355941 catgtacata ttgagtcgtc aatggttaca ccgattgagt tcgctaaagc agtgttgcct 1356001 catggcgtga cgacggttgt tacagatccg catgagatcg cgaatgtgtc tggtgaaaaa 1356061 gggattgagt ttatgcttga acaagctcgg catacaccgc tgaatatcca ttttatgctt 1356121 ccttccagtg tgcctgccgc aagttttgag cgatcaggcg caattctcaa agctgccgat 1356181 ctcaagcctt tttatgaaga agaagaagta ttagggctgg ctgaagttat ggattatgtg 1356241 tcggttcagc aggctgaaaa agacatggtt cagaaactgc ttgatgcccg tgtggcagga 1356301 aaaaggatag acggtcattt agctggttta tcaacagacc tcattaacat ttacagaacc 1356361 gcatttgtct taaacgacca tgaagtaaca tcgaaggaag aagcccttga tcgtatcaga 1356421 aggggcatgt atgtcatgat gcgtgaagga tcagtcgcca aaaacacgct caatgtgctg 1356481 ccggcggtga atgaaaagaa cgcacgccgg ttctttttct gtacggatga taagcatgtg 1356541 gatgatttat tgtcagaggg aagtgtaaac catcaggtga aaatggcgat tcaagccgga 1356601 cttaatccgt ttttagccta tcagctagga agcctcaatg cagccgaatg ctacggatta 1356661 gatacaaagg gagcgattgc cccgggtttt gacgctgatt tgctttttgt atctgatctg 1356721 gaaaatgtca ctgtcacaat gacgatggta aaagggcaga ctgttgctga agacagcaaa 1356781 gcggtctatc aggatcatgc ttcaactgca gcaccagatc aggcactgct tgattctgtt 1356841 aagcttgctg ctcctcttaa caaacaggat tttcatatgc caatcgattc agagcagcag 1356901 atcaatgtca ttcaaatcat accaaatcag cttgaaacac gattagtaca agttccggct 1356961 cctgttgccc gcgaatttga gcctgacact gagcttgatt tgttaaagat tgcagttgtc 1357021 gagcggcata aaggattaaa agaaaccgga cttggtgttg tgaaaggttt tggattcaag 1357081 agcggagcga ttgccacaac catttcacac gactcccata atattattgc cgtcggaacg 1357141 aatgatgagg atatcgcggc ggcagttaat aagctgcagg aaattggcgg aggattaaca 1357201 attataaaaa atggggaaga gctccattca gtaccgctgc cgattgcagg gttattatcc 1357261 gaccaatctg cagagcaagt gaatcaaagc ttgctgacgc ttcatgataa attgtcgtta 1357321 atcggtttca caggcggatt taatccattt ttgacattgt cgtttttagc gttgcctgtc 1357381 attcctgata ttaaaatgac gactacggga ttattcgatg taaaatcatt tcaacacata 1357441 tcactgcaat aaaaagaggc actcccttag ggagtgcctc tttttttaaa cctccataat 1357501 gatcggcagg atcattggac ggcgctttgt tttttcgtac aagaaaggtg caagcgtgtc 1357561 tgtaatttcg tttttgattt cagaccattg agtcgttttt cgttccatta ctttttgtaa 1357621 gtgatttgaa atgagctctt gagcgtcgtt gatcaagtca ccagattctc tcatgtacac 1357681 aaatcctctg gaaatcaaat caggacccgc tgaaatcttg aagtcgtcca tgtcaatgct 1357741 gacaacaacg atgacaagtc cttcttcaga gagaattctg cgatcacgaa gtacgatatt 1357801 gccaatatca ccgataccgc ttccgtcaat gtacactgaa ccggacggga tttttcctgc 1357861 aactgaagcc tcatcgcctt taagtgctaa tacttcacca ttatccatga taaagcagtt 1357921 ttcctctggg atgccacaat ctgttgcaag tttgacatgc atcttttgca ttctgtactc 1357981 accgtgaatc ggcatgaaga atttaggctt gattaaacga agcatcagct tctgttcttc 1358041 ctgtccgccg tgaccggatg tatggatatc gttaagaggg ccgtgaataa cctcagcacc 1358101 cgcacgatac agctggttga ttgttcgact cacgctgatt gtgttgcctg ggatagggga 1358161 tgaagaaaat acgactgtat ccccaggatt gattgaaatt tggcggtgtg tgccgtttgc 1358221 aattcttgat aacgccgcca ttggttcccc ttggcttcct gtacataaaa ttgttacttt 1358281 attagcaggc atacgattga tttcgttatg ctcaataaac gtatttttag gacagttaat 1358341 ataaccgagt gtctgtccaa tttcgatagc cgattccata ctgcgtccaa atacggcaac 1358401 ttttcttcca ttttgtacag cagcttcaat tacctgctgc aagcggtgaa tattcgacgc 1358461 aaatgtggcg aagataattc ggccgtccac cttgcggaaa atgtcatgaa tgctttctcc 1358521 tacacggcgc tcagacatgg taaactccgg attttcactg tttgtgctgt ctgaaagaag 1358581 gcacaaaacg ccttctttac cgatttcggc cattttcgtt aagtttgccg gctcgccgac 1358641 tggagtaaag tcgaatttga aatccccagt atgtacgatg tttccgggcg gcgtttttac 1358701 aacaatgccg taggaatccg gaatactgtg tgttgttctg aagaatgaca cagccgtttt 1358761 gcggaacttt acaatatcat cctcgccgat aatgttcagt ttcgtctgtc tcaataatcc 1358821 atgctcttca agtttattcc gaagtaagcc gatcgcgagt tttccgccgt atacaggaat 1358881 attcacttgt ctgagcaggt atggaatacc gccgatgtgg tcttcgtgcc cgtgggtgat 1358941 aaaaagccct ttaattttat cttcgttttt gactaaatac gtataatcag ggatgacgta 1359001 gtcaattccg agcagttcgt cctcgggaaa cttgatcccc gcatcaatca gtacaatttc 1359061 atcctggaat tgcaccgcgt acgtattttt accgatttcg cccaaacctc cgagggcgaa 1359121 aacagcagtc tgatcatttt ttacaaattt cataccgctc ataactccaa tactttaaaa 1359181 ttttcgctct gttgttcata ttctaagaat gcaccatcaa caggtgtaat aaactcaata 1359241 ttaaatttct tttctttcag ctttgttctg acgtcacgct cagatacgcc ttcaatataa 1359301 agtgaatctg tcttttcccg aacaggtact tcgtcagcct tctcttgata aaatacctta 1359361 taaatcattc caaatctctc cttaaatgcc gtatgttaga ctcgctcatt ctattatatt 1359421 cgaaaacgga atataaggaa agccttgagc aaaataagga tctctcaaaa agtgaaagat 1359481 cccttgtcag gcaattgctt tcttacggag cattccgttc cattgtcttc tgagtttctt 1359541 tcttaattta cgcagcatta gccagtccct cctttaatga aaaatttgtc ccagagttct 1359601 tttatacaaa tagtatacgg agattgagga agacttttcg tggttattaa tggaatttaa 1359661 tatgattttt gaacgaaatt gtttgctgaa tgacaatctt tttgtatgat gagggtggga 1359721 attgcagacc aagacgataa aggggaagtt gcgatggatt ctaaattaat cttttttgat 1359781 attgacggca caatatatga tcatgataag aatataccgg aaagtacgag aaaaaccgtg 1359841 gcggagcttc agcgccaagg gcatcatgtg tttattgcca gcggccggtc tccatttttg 1359901 gttaagccga ttttggagga gctgggcatc cactcattta tttcctacaa tggacagttt 1359961 gttgtctttg aaaatcaagt gatttataaa aatccgctgc ctgaaaatgc aatcaggcga 1360021 ttattaaagc aggcggatga aggcaagcat cctgttgtgt ttatggctga ggacacgatg 1360081 aaagcgactg ttgcggatca cccccatgtt ctcgagggaa tcggcagcct taaaacagat 1360141 tatccagaga ccgatgacct tttttatgaa ggaaaagaaa tttttcagct tcttttattt 1360201 tgtcaggatg aagaagaaaa agcttatgcc gcttttcctg agtttgatct agttcgctgg 1360261 catgagctat cgactgatgt tctgccgcac ggaggttcga aggcagaagg aatcaaaaaa 1360321 gtgattgagc gtcttccgtt tgatatcggc gatacatatg ctttcggcga cggattaaat 1360381 gatttgcaaa tgattgaata cgttgggaca ggcgttgcta tgggaaatgc tgttcccgaa 1360441 ctgaaagaaa tcgcggactt tgtaacaaaa ccggtggacg aggatggaat tgcatacgct 1360501 gtcaaagaat tgggcctttt aaaataaaga aacggctggc attgtgccag ccgttttctc 1360561 ttttagcgct caattgcgat tgcattttca ggttctttga aaggattttc cttatcaata 1360621 tgatcataga acataacgcc gttcaaatga tcgatctcat gctgaaacac aatagccgga 1360681 aatcctttta aacgaatatc aatattttcg ccttctagtg ttgttccttt tactctgatg 1360741 cgagcatagc ggggaacata accgggaatc gcttcatcca cagagaggca gccctcgccg 1360801 cttgttaagt agcttttttc aactgaatgg ctgacgatct taggattaaa cagagcatag 1360861 ctgtataatt taccggaagc atcttccgca tgaacggcga tcattcgttt tttgatatta 1360921 atttgaggag ctgcgagtcc tacgccaggg cgcagcttgt atttttcggc taattctgga 1360981 ttttggctgt ttttaacaaa ttcgatcatg tcggccagct gctgtttttc tgcatcagtt 1361041 ggaggcagct caacaggttc ggcagtctct ctgagggctg gatggccgtc acgtacgatg 1361101 ttttccatag taatcaagaa acttcactcc taaagcttaa tatgtaaatt atatcggatt 1361161 tcttcacaaa ggtgcaacga aacgaatgac cagccgtata tggctggtca atttcatgct 1361221 gtgtggttag caacagcctc cacctaaata agcagctccg acaatgatta acagaatgaa 1361281 taaaacaacg attagcgcaa aggtgcggcc gtagccatat ccgcagccac catatccgta 1361341 accaccataa ctgcagcagc ctccgccgta accatatcca tacatattac ataacctcct 1361401 cttttaatta cgccagagcc tttataagta ggcatagcgt ctaatataac ctatgtaaaa 1361461 acaaaaaagt tgtatggtca tctgtcctga tttttcactt ttttgattta atttcagtat 1361521 tgcatttata cagcacggct attgccaaat gtccccatgg attctatagt agaaattgtc 1361581 aagattgggg gatttaacgt gaaagacgct ataaaacggc ggcctggaat caagatcgga 1361641 gctttttgtg ccatggcact gatattaaca ggatgcatgg gacaggaccc ggttgattca 1361701 cttcatcatt cattagaaaa agccgcggaa tcggaaaagc cgtttcaaga agaacaaaac 1361761 acactcaaag aattagaggc caaagaaaat cagctttacg atagtgttat gaagctcaat 1361821 atggatgatt ataaaaaaat tgttgcttta tctaataagg cgcttgaaaa tgtcagcaag 1361881 cgcgaagaac acctaaagct tgaaaatgac agcatgaaaa aatcggaaac agaatttgag 1361941 gaagcaaaaa cgtcagcgga acatattaag gaaaaagaca taaaagaaaa ggccgatgcc 1362001 gcagcaaacc atatggagaa aagatataca tcatatggca ctatgtataa agagtataaa 1362061 aaagcgcttg agcttaataa aaaactgtat atgcagctga aagacaaaga tttgacaaga 1362121 gatgatctgg atcagcagat cgataaagtc aatgcttctt atgaaaagat ccttaaatat 1362181 agcggagaat ttaatgaaca aaccgaaaaa tataataaag cccgggaaga tttatatgat 1362241 gctgcaggct atcgtgtgaa aaagagctga ctcgatcagc tctttttttg aatgaaatgc 1362301 gattcggatt tcgttcaaaa ttttcatttc tattgtagta cagcatagta aggtatacta 1362361 gtacagtttt gggtgcggtt ggcatctgtt tttttgatga aaatgtaaag cgaatacatt 1362421 tattgaaaat cagcgatgaa aacgattgac ggttcttctt tatttggtgt aaactaatcc 1362481 atgttaagcg gtgttgtatt agttttttac aacttcgaaa taatacagtt caaagcagag 1362541 tgtaactatc ctacataaaa ggttttggca aactggggat cggctaaaat ataatacgac 1362601 ttactgctga tactttaggg taccctaagt ttgtatgtat aaaaggaatg cacgtctaat 1362661 gactgtttaa aagaaaggaa gaggtgactt agtatggctg caaaaacgaa aaaagctatc 1362721 gttgacagta agaagcaatt tgatgccatt aaaaagcagt tcgaaacgtt ccaaatttta 1362781 aatgaaaagg gagaagtcgt gaatgaagcg gcgatgcctg atttaactga tgatcaatta 1362841 aaagagctaa tgcgccgcat ggtatttacg cgtgtgcttg accaacgctc tatctcatta 1362901 aaccgtcaag gacgtctcgg attttacgct cctactgcgg gtcaagaagc ttctcagatt 1362961 gcaacgcatt tcgcgcttga aaaagaagac tttgttcttc ctggataccg tgatgtgcct 1363021 cagttaattt ggcacggcct tccattatat caagcgtttc ttttctctcg cggacatttc 1363081 agaggaaacc aaatgcctga tgatgtgaat gccctttctc cacaaatcat tatcggtgct 1363141 caatacattc aaactgccgg tgttgcgcta ggtcttaaaa aacgcggtaa gaaagctgtc 1363201 gcaatcactt acactggtga cggcggagct tctcaagggg acttctacga aggaattaac 1363261 tttgccggag cttataaagc acctgcaatc ttcgtggtgc aaaacaaccg ttacgcgatt 1363321 tcaactcctg ttgaaaaaca atctgcagct gaaacaattg cacaaaaagc tgtagctgcc 1363381 ggtattgtcg gcgtacaagt agacggaatg gatccgcttg ctgtatacgc agcaactgct 1363441 gaagcacgcg agcgcgcaat caacggcgaa ggtccaacac taattgaaac acttacattc 1363501 cgttatggcc cgcacacaat ggctggtgac gatcctacta aatatcgtac aaaagaaatc 1363561 gaaaatgagt gggaacaaaa agatccgctt gtacgtttcc gtgcgttcct tgaaaacaaa 1363621 ggcttatggt ctgaagaaga agaagcaaaa gtgattgagg atgcgaaaga agaaattaag 1363681 caagcgatca aaaaagctga tgctgaaccg aagcaaaaag taactgattt aatgaaaatc 1363741 atgtacgaaa aaatgcctca caaccttgag gagcaatttg aaatttatac acagaaggag 1363801 tcgaagtaag ccatggcgca aatgacaatg attcaagcaa tcacggatgc gttacgcaca 1363861 gaactgaaaa atgacgaaaa tgtcttagtt ttcggagaag acgttggtgt aaacggcggc 1363921 gtattccgtg cgacagaagg attgcaaaaa gaattcggtg aagaccgtgt gtttgacacg 1363981 ccacttgctg aatctggtat cggcggtctt gcccttggtt taggcttaaa cggcttccgt 1364041 ccggtaatgg aaatccaatt cttcggattt gtttatgaag taatggattc agtttctggc 1364101 caaatggctc gtatgcgcta ccgttctggc ggacgctgga cttcacctgt aacaattcgt 1364161 tctccattcg gcggcggtgt tcatactcct gaacttcacg ctgacagctt ggaaggtctt 1364221 gttgcacaac agcctggtat caaagttgtt attccatcaa ctccttacga tgccaaagga 1364281 cttttaattt ctgcgatcag agacaatgat cctgttgtct tcttagagca tatgaagctt 1364341 taccgttctt tccgtcagga agttcctgaa gaagaataca caattgagct tggaaaagct 1364401 gacgtgaaac gtgaaggtac tgatctttca atcatcactt acggcgcaat ggttcatgaa 1364461 tcattaaaag ctgctgatga gcttgaaaaa gacggcattt ctgctgaagt tgtcgacctt 1364521 cgtacagtaa gcccacttga tatcgataca attatcgcct ctgtagaaaa aacaggacgc 1364581 gcgattgtcg ttcaagaggc acaaaaacaa gccggtattg ctgcaaacgt agtagcagaa 1364641 attaatgacc gtgcgatcct gagcttggaa gcacctgtac ttcgcgttgc agcgccagat 1364701 acagtatttc ctttctctca agcggagagc gtatggcttc caaaccataa agacgttctt 1364761 gaaacagcaa gaaaagtgct tgaattttaa tcaaactgca taatcgagag ggaagatgaa 1364821 cgttttccct ctattatata tctgttttca atgcttacga tgtaaacttt aaaattgctt 1364881 aatcaaacta ggaggtcgag aactgtggca tttgaattta aacttccaga tatcggggaa 1364941 ggtatccacg aaggcgaaat cgtaaaatgg tttgtcaagc ctaacgacga ggtagacgaa 1365001 gatgatgtac tggctgaagt ccaaaatgat aaagcagtag tagaaattcc ttcacctgtt 1365061 aaaggaaaag tattagaatt aaaagttgaa gagggaacgg ttgcaactgt tggacaaacg 1365121 attattacgt ttgatgcacc tggttacgaa gatcttcaat ttaaaggcag cgacgagtct 1365181 gacgatgcga aaactgaagc acaagttcag tcaactgcag aagctggaca agacgttgcg 1365241 aaagaagagc aagctcaaga gcctgcaaaa gctactggcg caggacagca ggatcaagct 1365301 gaagttgacc cgaacaaacg cgtgatcgct atgccttccg tacgtaaata tgcacgtgaa 1365361 aaaggtgtag acatccgtaa ggttactggt tcaggcaaca acggacgtgt tgtaaaagaa 1365421 gatatcgaca gctttgtaaa cggaggagcg caagaagctg caccgcaaga aacagctgca 1365481 ccacaagaaa cagctgctaa accggctgct gcaccagctc cagagggcga attcccagaa 1365541 acacgcgaaa aaatgagcgg tatccgtaaa gcaattgcaa aagcgatggt taactctaaa 1365601 cacactgctc ctcacgtaac gttaatggac gaagtggacg taacaaacct tgttgcacat 1365661 cgtaaacagt tcaaacaggt tgctgctgat caaggaatca agctgactta cttgccttac 1365721 gttgtaaaag ctcttacatc tgcactgaaa aaattccctg ttttaaacac gtcaattgac 1365781 gataaaacag atgaagtcat ccaaaaacat tacttcaaca tcggtatcgc tgctgacact 1365841 gaaaaaggct tgcttgtacc ggttgtgaaa aatgcagatc gtaaatctgt ctttgaaatt 1365901 tctgatgaaa tcaatggcct tgcaacaaaa gctcgtgaag gcaagcttgc tccagctgaa 1365961 atgaaaggcg catcttgcac aattacaaac atcggttctg ccggcggaca atggttcact 1366021 ccggttatca accatccaga agttgcgatt cttggtatcg gacgcattgc agaaaaagcg 1366081 attgttcgtg atggcgaaat cgtagcagct ccagtcttag ctctttctct cagcttcgac 1366141 caccgtatga tcgacggagc aactgcgcaa aatgcattaa atcacatcaa gcgtttactg 1366201 aacgatccac aattaatttt aatggaggcg taatgttatg gtagtaggag atttccctat 1366261 tgaaacagat actcttgtaa ttggtgcggg acctggcggc tatgtagctg ccatccgcgc 1366321 tgcacagctt ggacaaaaag taacagtcgt tgaaaaagca actcttggag gcgtttgtct 1366381 gaacgttgga tgtatccctt caaaagcgct gatcaatgca ggtcaccgtt atgagaatgc 1366441 aaaacattct gatgacatgg gaatcactgc tgagaatgta acagttgatt tcacaaaagt 1366501 tcaagaatgg aaagcttctg ttgtcaacaa gcttactggc ggtgtagcag gtcttcttaa 1366561 aggcaacaaa gtagatgttg taaaaggtga agcttacttt gtagacagca attcagttcg 1366621 tgttatggat gagaactctg ctcaaacata cacgtttaaa aacgcaatca ttgctactgg 1366681 ttctcgtcct atcgaattgc caaacttcaa atatagtgag cgtgtcctga attcaactgg 1366741 cgctttggct cttaaagaaa ttcctaaaaa gctcgttgtt atcggcggcg gatacatcgg 1366801 aactgaactt ggaactgcgt atgctaactt cggtactgaa cttgttattc ttgaaggcgg 1366861 agatgaaatt cttcctggct tcgaaaaaca aatgagttct ctcgttacac gcagactgaa 1366921 gaaaaaaggc aacgttgaaa tccatacaaa cgcgatggct aaaggcgttg aagaaagacc 1366981 agacggcgta acagttactt tcgaagtaaa aggcgaagaa aaaactgttg atgctgatta 1367041 cgtattgatt acagtaggac gccgtccaaa cactgatgag cttggtcttg agcaagtcgg 1367101 tatcgaaatg acggaccgcg gtatcgtgaa aactgacaaa cagtgccgca caaacgtacc 1367161 taacatttat gcaatcggtg atatcatcga aggaccgccg cttgctcata aagcatctta 1367221 cgaaggtaaa atcgctgcag aagctatcgc tggagagcct gcagaaatcg attaccttgg 1367281 tattcctgcg gttgttttct ctgagcctga acttgcatca gttggttaca ctgaagcaca 1367341 ggcgaaagaa gaaggtcttg acattgttgc tgctaaattc ccatttgcag caaacggccg 1367401 cgcgctttct cttaacgaaa cagacggctt catgaagctg atcactcgta aagaggacgg 1367461 tcttgtgatc ggtgcgcaaa tcgccggagc aagtgcttct gatatgattt ctgaattaag 1367521 cttagcgatt gaaggcggca tgactgctga agatatcgca atgacaattc acgctcaccc 1367581 aacattgggc gaaatcacaa tggaagctgc tgaagtggca atcggaagtc cgattcacat 1367641 cgtaaaataa ttttcatatc aaaaacagcc ccgctttgag cgagggctgt ttttttattt 1367701 tgacagcaca tgctgtaatg gtttaatgat gtcttctttc tttttcacac atccctcgat 1367761 tttcaccacg acatggcgct gatcaacaac cataagggta gggacagttt caatctcatc 1367821 ttcccagcct tcttttttat catagacctt cattttatct atttgctcgg gataatcttt 1367881 ttctaaatca agcagtgcat cgtaataagg cgcttcctgg tctatttggt tctcatcaga 1367941 aaaaaacagg atttgtgtat gatgaatgtt gtcaatccgg ctttttttca tcggattgat 1368001 ggtggaaagc gtacagcccg ataaagcaaa tactattatc agcatgggga ataccgcgcg 1368061 atatcgcatc tatcttctcc tctgtataaa cagtagttaa ctagctttag tttatcacga 1368121 gagacggctt aatctgcttc ttgttaccta attgttatat aattgaaacc gtttttaaag 1368181 tgagattaca tattatatca atcgtttaaa atagcaacct ggggtatatt gaattttttg 1368241 ctgcattctt ggatgaaagt tcaagaaaac gtgcaattac attatgtgct gtggcatata 1368301 tatcgagtaa agcttctgta tgaagaagat attgtatgat ggaaaatgga aaaacaaggt 1368361 gaatatgatg atatgaaata aaatgtgtta tacagtttgt tgttgacatt ttaaatgtga 1368421 catattaata taataacaac aaaagaaatt aagcgttttc aaatttcaaa gaaatgggga 1368481 ataagagatg ggtacgattg tttgccaaga ttgcaacgaa gccattcatt actttgaaga 1368541 tgagaaagtg acaacattat atggaacttg ctgcggacaa tgtcaatgtc ctgttgatga 1368601 agagtaaaaa aaagcatgcg gcttaaagcc gcatgctttt tattttttat tgaattgctt 1368661 tttgttcttt gatgacccgg atcatatgta aagtcgagtc ctcaggtcct tgaacaggga 1368721 ggcctgcgtc aaggttttta aaaatgtagc tgatgttttc ttctgtaata atttctcctg 1368781 ggatgaagat tggaatacca ggcggatata ccatgacaaa ttcagcaata atccgtccgg 1368841 atgcttcttt taatgggatg acttccgtat ttgcatagaa agcatcacgc ggagtcattg 1368901 ccaataaagg tatttctgga agcagaacct cagtttgctg atgtgttaca tcttgttctg 1368961 acatttgctg tgcgatctca gttaaagcct ctacaagccg gtctgcatca ttttggctgt 1369021 caccaggagt gaaaatacac aaaatattgt acagatcaga aagctccacc tcaatattaa 1369081 aggattcacg aagccatttt tccacgtcat gtcctgtcag gccaagactt ttcacagaga 1369141 taatcaattt tgtcggatca tagctgtaag ctgctttcga cccaagaatc tcagaaccga 1369201 cacaataaat gccttcaatc tgattgaggc gatctctcgt ctgattggca agcttgagtg 1369261 tttcctcagc aagctggcgg ccttctgttg caaggcgttt tctggcaaca tccaaagaag 1369321 cgagaagcaa gtaagaagtt gacgtagttg tcagcatgct caggatggat tgcactctgt 1369381 ctttagatac aaggccttct ctcatgttta aaatagagct ttgtgtcagt gatccgccca 1369441 gcttgtgtac acttgtcgct gctatgtccg ctcctgcctg catagccgat agcggcaatt 1369501 cgtcgtgaaa atgaatgtga acgccgtgtg cttcatccac aagcactggc acatcaaacg 1369561 aatgagcgag ttctacgatg ctttttaagt cggctgcaac accgaaatat gtcgggttga 1369621 tgacgagaag cccttttgca tccggatgct cggtaagcgc ccgtttagca gattcaagtg 1369681 taattccgtg ggagatgccc aattcattgt caatttcagg atgaataaaa attggaaccg 1369741 ctccggaaaa tacaatagct gtcataattg atttatgaac atttcttgga ataataattt 1369801 tatcaccagg tccgcaaaca gccattacca ttgtcataat ggcgccgctt gttccttgaa 1369861 cagaaaaaaa tgtatgatcc gctccaaatg cttcagcagc cagatcttgt gcttgtttaa 1369921 taatgccttt tggcgcgtgc agatcgtcta atggttcaat attaatcaaa tctatgctta 1369981 acgcgttttc accgataaat tgtctgaatt ctgggtccat tcctgcccct tttttatggc 1370041 cgggaatgtg gaattgaaca ggctgtctgc ttgcatgctt tttcagtcct gtgtataagg 1370101 gtgtttcatg ttgcgacaat tgttttccca cctttgtaat catacctatg cataatagtg 1370161 tgtattaaaa tcagtttctc aaccgttttt tagacgtaaa acaaatgaat tatattatga 1370221 acttgaaaga atgtaaagct agacaaaatt gatagtattg tcctgtgttt gtttttgttg 1370281 aataatatca agatgagtca agtgtcatgt ggtggttcat tcaagagtta tgttttttac 1370341 atatcaaggg gaagatgaga tatttttgtt tcatcttgaa actttttgaa aagtccgctg 1370401 tctaaccgaa tgaggcctta ataagaagta aaggattgtt gttcgtgttg gagttattca 1370461 gtcattatgt attgcatttc gaacgttatt ttatattaag cagacaaagc accctgctga 1370521 ttcaatggtc aattgttgtt ctggcgggct tatatctttt ggtgcatcat cccaaaataa 1370581 accggcagcg cacaatgttc ttggcgggtg ttatattgcg gattgtgctg ctggcgggag 1370641 tgtctgttga acttattcac caggtgcaat caacaaactt caccagcgct tacttaagag 1370701 aggacggaaa agaactgctg ccgctgctgc attttttgtt atacggatat gtgctgctga 1370761 cggcttttca ctatatgctg atgccgcgtg atcatggcgg aaagggtaag ttttatacgt 1370821 tcgaccttgc tgttgtcagt ttgccgatcg tacaaatgat ttttagtttc ttttcgtatt 1370881 ggaaggaata cccggatggg atggagccga ttgcattcgt gtttctgttt ttcatcatca 1370941 ctcttcccat tgcgttgaat gtagtgtttt tcaagctgta ttggagaacg gataagatct 1371001 tactaggctt attttatacg ctgattatcg gactgcttgt cttgctgctt gcgccatatc 1371061 ccaatcaaat ctcaaaagat tatggtgcag taatgccata tacgatttat ttggcaatgg 1371121 cgggattttt gatgagctat catctgttcc aaaagtcagg aaaggtttat gtgcgtgtga 1371181 ataagtgggt gacgatggct gtcatggtgt tttttgtcct gctgttaaat ccgatatata 1371241 acataggaac ggctgctttc gctgtatcaa agccagcaaa tgtccatgat tcattcaatt 1371301 ttgtcgggga gcacatttca tcagaaaaag cggaacagat actaaagtca ttttttccta 1371361 cggatgaaac actttatttg cacgatacaa acatggatgt gcattatttc tactcatttg 1371421 aaagcaaagg ttacaaagct gaggtagatg aagtatcgca gctaattcgt aattatgaat 1371481 acttacaaaa agcacatggg aaaaagctaa cgaatcagga gtacaagcga aagtccatcg 1371541 ctttccttga gcgacacgga cgtgtgttac ataaggatca tatcgaaaca aaggtatctc 1371601 aagaagacgg ccagacagtc gtacgtattt acctgaaaaa tcaacttcat aaaaaagatc 1371661 atgctgatga tggcgcggta ttttattggg aaaaggaaac cttaatgggg tttagtgaag 1371721 atccttcgat ttatcagctt gactctcttc tgcatgttca tataacggaa caagacattc 1371781 acgacaaagt ggaacaaatg tttacagcgc tgaacatatc aaaacagcct tatcagatca 1371841 ctgatattga aagcgacagc ctgcttggaa gcatggtgag agttgaaaca aaagttggaa 1371901 ttgttttgga atttgagggc gaatcaggtt gtttacatag tctttcgctt ccgatgaaaa 1371961 agaatatctc aatggctaac agccggctgc agcatcagat attatcgatc ttcgatgctc 1372021 gtggatcaga aaagaagaaa aaaagcagtc agggtgacat ggtgatgtat actgattctt 1372081 ctaaaacata tgagtttgtt gaagctcaag gtcagctaaa cgtttatgta tacagcgata 1372141 cacctgatca gtcattcccc tatacgtatc gtaatggaac attggcttac gaaaaagtag 1372201 cttctctata tcaggatgtc atttacaaaa agcgtatgcg tccgattatc gttcaaagag 1372261 gggatgaacg gcattatgca tggctgatca ttattcagcc gtttggttca aatcgccatg 1372321 atgcctatgt agtggatgga gaaacacaag aggtgaaaag tctttatgaa tcataaagaa 1372381 aaagagtctg tttttgtaga cttatacgac ctgtataaag aaggagagct agaggatgaa 1372441 tcaatggaat ggatgaaaca gcatgaatcc ctatttcaaa agaatgcgga agacttaaag 1372501 agtaaaactt gtttaaagag aagtcccggt gctgaagaag aaagccaaat cagatatatg 1372561 aaagtatacc tgtcttccat gtatatctgt ttcattttat tggccatttg gatgacggtg 1372621 tggttttatt tttaatgaag catagggatt ccattgagga cttgtatcgg cagtattatc 1372681 aagaaatttt aaattattta ttcagaagga ctcatcatct tgaaacagcc aaggacttag 1372741 cgcaggacac gtttgtaaaa gctcttaacg gtctggcttc gtttaggggg cattcttcca 1372801 tcagaacatg gctctacacc attgcgcatc atacctttat caattggtac cgaagggatg 1372861 tcaaatacca atttactgaa atcagcaaaa atgaagggtt aacgcaaaca acttatgacc 1372921 agcctgaaca gtatctgtca cggacggtga aaagcgaaac actgcggcag gagctcctga 1372981 agttaaaaga tcagcatcaa tccgttttga ttttaagaga attccaagag ctttcttatg 1373041 aagaaatcgc tgagatatta ggatggagtc tttctaaggt gaataccaca ttgcaccggg 1373101 ctagattaga gctaaagaaa aacatgacga aaagtagaga ggaggagcgg atatgacctg 1373161 ctttctagta agagacctgc ttcctctgta tcttgaaggt gattgtaaaa gagaaacgga 1373221 acacgttata gaagagcatt taaaaatgtg cagcagctgc agagacatgt atgacacgat 1373281 ggctgagcca tttgaattgg aaagcgaaca ggccgttgag gaggcttatc tgccggaaga 1373341 agaactgcgt tttaaacaga ggtactatgg attactgatc atgaaagctg cctgctggtt 1373401 tggagcggcg gttgccatga tgctgatcat caaactgctg atataaaaaa agcgcttgtc 1373461 cgattccggc aagcgctttt ttacattaag cctggggatg aatcatatcg taaatagcgg 1373521 caagctgttc ttgtgacagg gcactgaaga gtttttcata aacgtcagct tgcagtggcg 1373581 ttgcacctgc ttgtagcgct gcgtctttat catagctgta cacatcatct tgtagcacaa 1373641 tggctgcttg aagaatgtga atcttgagag aaacagcgga gaaaaattgt tcaagtgcaa 1373701 gtgcttcttt ttctgtgaag ccaagttcaa ctgctttttc tgtatcaaat ttgtaatttc 1373761 catcctcgag atacacacat tgtgaaacaa tgctgaaaaa ttctgatgtc gattcccaga 1373821 gtgtagcaat tacctgagcc tcttcttttg tcattcctaa ctcgacagct ttttcgctgt 1373881 caaaataata tacaccgtct tgttcgtata tacattgatt taatatatca atgaatgtat 1373941 tgagatcttc gttagtgctc gcctgatgct ggagttgaac agcagtgtta tcaaccggtg 1374001 tttttgcgct ggctgcatca ggaccgaacg ttaatagagc agctgaggtc attgcggcag 1374061 tcgttaacat agcttttttt acaaatgttt tcttcatgtt tcttctctcc cttttatgaa 1374121 ttgtgctaca aattccatta tagggagtag tttccggtgg aggaataggc gctatggtat 1374181 tttatgtgta tcgttgccga actacttttt gaaggctgca cgtgtgatcg ttagaacgat 1374241 tgtctatgta tgaaggctgt tttgcatctt cctgactaag aaacagggga gataaggctt 1374301 aaagaaatga aaaacaccgc tttctttgcg gtgttttttg attacaatgt cgccggcggg 1374361 gcaatgcttt taatcaagca agccttgttc gcgcattttc ttttttaatg taaatccgcc 1374421 gcccatgaca gcgcaaacaa gtacaatgct ggcgataatg cctgcagggc ttttttcagc 1374481 gataaagacg ccgatcagca taatgctgaa aaccgctgca aatgcaaata atagtaaaag 1374541 ccaattcatt tttttcataa attccatccc cttttacgtc ttatattaag tttacagaaa 1374601 aacgtgacgc ttttaaagag gatgtgtgat ataatatgaa agttatctaa tttttttagg 1374661 agatgaaaaa gtgaaacttc gaaatgatct tcgcaacatc gcgattattg cccacgttga 1374721 ccatgggaaa acgactctag tcgatcagct tttacatcag gctggtacgt tccgtgccaa 1374781 cgaacaggtt gctgaacgcg caatggactc taatgatctt gaacgcgaac gcggcattac 1374841 aatattggcg aaaaatactg cgattaacta taaagataca cgtatcaata ttttggacac 1374901 ccctggacat gcagactttg ggggagaagt agaacggatt atgaaaatgg ttgacggcgt 1374961 agtgcttgtc gttgacgcat atgaaggctg tatgcctcaa actcgttttg ttctgaaaaa 1375021 agctcttgag caaaacctga accctgttgt tgttgtaaac aaaattgacc gtgactttgc 1375081 tcgtccagag gaagttatcg atgaagttct ggatctgttc attgagcttg atgccaatga 1375141 agagcagctc gagttcccag tggtatatgc ttccgcgatt aatggaacag cgagtcttga 1375201 tccgaaacaa caggatgaaa acatggaagc tttatatgaa accattatta agcatgttcc 1375261 ggcacctgtt gataatgcag aggagccgct tcaattccaa gttgcccttc ttgactacaa 1375321 cgactatgta ggccgtatcg gaatcggacg cgtattccgc ggcacaatga aagtcggaca 1375381 gcaggtttct cttatgaagc ttgacggaac ggcaaagtca ttccgtgtta caaagatttt 1375441 tggtttccaa ggcttaaagc gtgtggaaat tgaagaagca aaagcgggag acctcgttgc 1375501 ggtttccggg atggaagata tcaacgttgg tgaaacggta tgtcctgtag accatcaaga 1375561 tccgcttccg gtccttcgca ttgatgagcc gacacttcaa atgacatttg tcgtgaataa 1375621 cagtccgttt gcaggccgtg aaggcaaata tgtaacggcc cgcaaaatcg aagagcgtct 1375681 tcaatcacag cttcagacgg atgtgagctt gcgtgttgag ccaacagctt ctcctgatgc 1375741 ttgggttgtt tcaggacgcg gtgagctgca cttgtcaatt ttaattgaaa atatgcgtcg 1375801 tgagggctat gagcttcaag tgtcaaaacc tgaagttatt atcaaagaaa tcgacggcgt 1375861 acgctgtgag cctgttgaac gtgtgcaaat tgatgttcct gaagagcata ctggctctgt 1375921 aatggaatca atgggtgccc gcaaaggcga aatggttgat atgatcaaca acggaaacgg 1375981 ccaagtccgt ctcatcttta cagttccttc ccgcggattg atcggttact ctacagaatt 1376041 cctatcatta acacgcggat tcggtatttt gaaccatacg tttgacagct accagccgat 1376101 gcaggcaggc caagtcggcg gacgccgtca aggtgtactt gtgtcaatgg aaaacggaaa 1376161 agcaacatca tacggtattc aaggaattga agaccgcggt gtcatcttcg ttgagccggg 1376221 tactgaagta tacgaaggaa tgatcgttgg agagcataac cgtgacaacg accttgttgt 1376281 taacgtcagc aaaatgaaac agcaaacaaa cgtccgttct gcgacaaagg atcagacaac 1376341 tacaattaaa aaagcgcgca tcatgtctct tgaggagtct ctagagtact taaacgaaga 1376401 tgaatattgt gaagtaacac ctgaatccat ccgtttaaga aagaagatcc tcaataagaa 1376461 cgaacgtgaa aaagcagcta aaaagaaaaa aacagcagga ttgtcttaat ctcgtgcaga 1376521 atttgaaaag atagaacccg tacgtttaca ggggagggaa tctttttgaa tgacgtaagc 1376581 gaacgcctgt cgttcttcgc cgctctatat caagtagacc ggcagcctgc ggcaggcatg 1376641 tggctgctgt acggcacgat ttttgtgttg gccgttattg tatttaagct tggatttgct 1376701 aaacggcttc ctgtattaaa atctgcagtg gtgtatgtat ttttggcttt gggctgcact 1376761 gttttgactt ttttaggggt gtttttgccc gtggcagaag gattggtcgt cgctgcgctg 1376821 attttaatca tttacaaaat ccggctgtat cagtcgaaaa aaggacagtc tgcaaaatca 1376881 taaaagactc agctgaaagc tgagtctttt ttgtgttctg tatggttaag cggccgcttt 1376941 attttttgac tttttctttt ttctgctgtc ccgggtgaaa agtaaatttt cccgttttca 1377001 gccgttcctc tgtttttttg gcaatccgat cgtggcattc ctggcacata tatgtatgga 1377061 tcgggcggtt tcgaagccgt ttcgcgatca gggtatcatc atcaattgtt tcaattttat 1377121 cgcaaataga acatttgacc ctcatcatat cacctctttc actaacatgt attataccac 1377181 ggatcagaag ctgtccaaaa taagaaaaag ctaaagcgca aggctatagc ttagtcattg 1377241 ttgttctttt tcatatgatg atcagattga tcgttttgtt ccttctccat ttcctgttgc 1377301 tgttttctat ttaattggtc attttgctgc tttgtttgcg gttcatcttc attgtcaatc 1377361 acatcgttag gcacttcggg aagcactcgg ccgacaattg cagctaattc atccagtata 1377421 cctgttaccg gatggccctc gctgatttct ctgctcattt cgcgaaggcg gctgaccgta 1377481 tcgggatcag caatgactac tgcgttggcg ccatatcgat cattctttag cgcctgagct 1377541 acagaatatt taatggtttc cactttgctt ctgtccaaag tatcatcgac atcaatccca 1377601 acaacagcat agcctcccag cacaacggct gttgcatcct tgacgtcggg gtttttttca 1377661 gcaacgctga caagatgctt ggcaatatcc gttcttgttc cattgtcttt tgtttcttga 1377721 gttgtgtcct ttacgtgaat cggtttagtc tcctgctgtc ttgttgattc tttttcaaca 1377781 ttctggccct gttttccttg ttgataggca caagcggaca ggataagtgt cagctgtatg 1377841 ataatgaaaa gaattcgcac ttgcgggttc cctccttaaa atgctttcat taattttatt 1377901 gttgaattaa ccttctatct ttatgcacaa aaacatatat tttagcaggc attcaccttt 1377961 ttcatcaaaa gagaagcagg aagaactttg acccttatat caggaggctg agacttgagt 1378021 aaaatttatg tgttagatac gaatgtgtta ttacaggatc ctaacgcgat attttctttt 1378081 gaagaaaatg aggttgtcat ccctgctgtc gttttagaag aggttgattc aaaaaaacgg 1378141 tatatggacg aagttgggag gaatgcaagg cacgtatcta agctaatcga tgcgctaaga 1378201 caaaagggca ggctgcatga gcatgtaccg cttgacaccg gcggcacact gagaattgaa 1378261 ctgaatcatc gttcgtttca ccagctgcaa gagatcttta ttgaaaagac gaacgataat 1378321 cgcatattag ccgttgcgaa aaacttaagc ctcgaggaag aaaccaagga aaatggcagg 1378381 ccggttatcc ttgtcagtaa ggatgtactg gtcagggtta aagccgacgc aatcggactg 1378441 cttgctgaag atttcttgaa tgaccgggtt gtggacaatg atgaaatgta cagcggctat 1378501 aaagatttat atatcagcca gcagctgttc agctcttttt acgggaaaaa tcaaatttca 1378561 gtaaacgatg tgaaacagca tgcgttttat ccgaatcagt ttgctttaat gaaggatgag 1378621 ctaggagggt cctcctcggc agtcggaatt gcagacaaaa ccggaacggt attaaaaaga 1378681 ctcgtatttg atgatgaaca tatatgggga atcaggccga aaaatgtaca gcagacaatg 1378741 gcattagagc ttttgctgcg ggaagatatt ccgcttgtca ccctgatcgg caaagcggga 1378801 accggcaaaa cgctcttagc tttggcggca gggctattac agacagaaga cttgggaata 1378861 tataaaaagc tggtcgtcgc aaggccgatt gttcctgttg gcaaggacat cgggtatttg 1378921 ccaggcgaaa aagaggaaaa gctaaagcct tggatgcagc cgatttttga caacttagag 1378981 tttctgttta atgcgaaaaa accaggggag cttgatgcta ttttggcggg aattggctca 1379041 attcaggtag aggcgctgac ttatatcaga gggagaagca ttccagatca atttattatc 1379101 attgatgaag cgcaaaattt gaccaggcat gaggtgaaaa cgttgctgac gagagtcggt 1379161 gagggcagta aaattgtctt aatgggcgac cctgaacaaa ttgatcaccc atatttagac 1379221 agtctgaaca atggtttggc ctatgtggtt gagcggttta aaggacaacc catctcaggc 1379281 agcgtgaagc tgttaaaagg tgagagatca ggtctcgccc agcttgcagc tgatttgctg 1379341 taacacttaa atgatttcga tctcttttac atcggtaatc ggctgtttgt gatgaaccgg 1379401 gtcttcaaag taaatatgca cggggccgcc ttcttgaatc ggcttgcctg cctcactgaa 1379461 atggacaata ctgttcagag cggtttccag agaaacggcg gcctttcccg aacttgtgac 1379521 aaatacacat tgtgtcgcag agctgttcgg ctcagcattt ttcaggacag tcccaagtct 1379581 cattgcgaaa ctgccgttca tcagtttttg cttctcatat tgcttttccg tctttaatgt 1379641 aggcggcgcg attcgcccct ctctgatgac gcgttccgga tcaaggtcgg attcatcccc 1379701 ggctgattgt aaatatgtgt cttgactgtc ccctttgcgg tcaaacgaaa atttgcgatc 1379761 atcaaaaatc catacgcttg gatcaatggt aattggatat gtaacattgc cttttacttg 1379821 gataacgctc atgatatgac ccccttctct caaaattata aaagttttcg catgaattgt 1379881 cactttgtgt acaaattatg tgtattgaaa tgctgaggga acgagggtgt ttgcatggta 1379941 tgccagcata atgatgagct tgaagcctta gtgaaaaagg cgaaaaaagt aacggacaag 1380001 ggggaggtag ccagctatat tcccgccttg gcaaaagctg ataaacacga cctgtcagtg 1380061 gcgatttatt attccaataa tgtttgtctg tcagcaggtg acgtagaaaa aacatttacg 1380121 cttcaaagta tatcgaaagt cctttccctt gctttggtgt taatggaata cggcaaagat 1380181 aaggtcttca gttatgttgg acaggagccg accggtgatc cgtttaattc aattatcaag 1380241 ctcgaaacag tgaatccgag caagccgtta aaccctatga ttaatgccgg ggcattggta 1380301 gtgacaagtc tgataagggg aagaacggta aaagagagac ttgattattt gctttctttt 1380361 atcagaaggc tgacaaacaa ccaagagatt acatactgcc gggaagtggc tgaatctgaa 1380421 tacagcactt caatgattaa tcgggcgatg tgttattata tgaagcagta cggcattttt 1380481 gaagatgatg tagaggcagt aatggattta tatacgaagc aatgcgcgat tgagatgaac 1380541 agcttggatt tagcgaaaat cggatctgta ttcgcattga acggcagaca tccagagact 1380601 ggggagcagg tcatctcaaa agatgtcgct agaatttgca aaacgtttat ggtgacgtgc 1380661 ggaatgtaca atgcaagcgg ggaattcgca attaaggtcg gaattcctgc gaaaagcggc 1380721 gtatccggcg ggataatggg catttcgcct tacgatttcg ggatcggcat attcggcccc 1380781 gcattagacg aaaaagggaa cagcattgca ggtgtaaagc ttttggaaat aatgtctgag 1380841 atgtacaggc tgagtatttt ttaatttatg tcatatgctt aaatcctctt gcattttctg 1380901 ttgataccct ttatgataaa tagaagaatt aggtactcgc ctggggaacg gagggatact 1380961 tttggcttca gagatgatag ttgaccatcg gcaaaaagct tttgaactct taaaagtgga 1381021 cgctgagaag attttgaagc tgatccgagt acaaatggat aacttaacga tgcctcaatg 1381081 tcctctatat gaagaggttt tagatactca aatgttcggg ctttcgaggg aaatcgattt 1381141 tgctgtccgc ctgggattgg ttgatgaaaa agacggtaaa gaccttttat acacattgga 1381201 gcgcgaattg tctgctttgc atgacgcgtt tacagctaaa taaatgataa aactcaaact 1381261 tattaacagt ttgggttttt ttataaccgc tatttttctc tcatctcata aaagacggtc 1381321 tttttttaca cattccttcc gaatcgtata gagattcttc gtctcgtttg ataaattgta 1381381 gtaaaataaa aaagataaat acataaaaac catagataat ggaagttaga agcagggaag 1381441 aggatgttat gttaaaaaaa atgctaaaat cttatgatta ctcactgata ttcgcaatcg 1381501 ttttattatg cggattcggt ttagtgatgg tatacagctc aagcatgatt acggctgtct 1381561 cccggtatgg agtaagcagt aattttttct tcatgcggca gctgtttgct ttaattgcgg 1381621 gtggcgctct atttattctc atggcgttgt ttccttataa agcactggcc catcaaaagt 1381681 ttcagaaggg gatactgctt gtatctgttc ttgcgcttat ctcactgttt gttttcgggc 1381741 atgttgccgg aaacgcgcag agctggttta aaatcggcgg aatgagtatt cagccggggg 1381801 agtttgtgaa actggtcgtg attttatacc ttgcagccgt atatgcaaaa aaacaaagtt 1381861 atatcgacca tctgttaacg ggagtagccc ctccggtagt catgacgctt ataatttgtg 1381921 ggttaattgc catgcagcca gatttcggta cagccatgat tatagggtta attgcgacgt 1381981 gcatgatctt gtgctccggc ttcagcggaa agacgctggt gaggcttgtg atactgggcg 1382041 gaattgtttt cattttagtc agccctatta tctatttgaa tcaggacaaa attttaactg 1382101 aaggccgttt agcgcgtttt gagagtcttg aagacccatt taagtatgca aattcatcag 1382161 gtttgcaagt gatcaattct tattatgcga tcagctcagg cggcattttc ggcctggggc 1382221 tcggtgaaag tatccaaaaa tacggatatc tgcctgaatc acacactgac tttattatgg 1382281 ctgtcattgc tgaagagctc ggcatttttg gggtattgtt tgtgattttc ttattgggtt 1382341 ttgtcgtcat aaaaggtttt tatattgcca gaaaatgcga ggacccgttt ggaagtcttc 1382401 tggcgatcgg catttcaagc atgattgcca tccagtcgtt tattaacctt ggcggtgtca 1382461 gcggattaat tccgattaca ggggttacgc tgccatttat cagttacggg ggctcttctt 1382521 tggtgctgct gctggggagt atggggatat tagcgaatat cagcatgttt gtgaaatatt 1382581 cagagaataa gaaaaagaaa gagcccttgg cgccgaaggg aatgaaaaag aaacagctca 1382641 aaaaaactgt ttatctgtaa aaaacaagtg tgtacagggg aaggatattc cgctatgata 1382701 gattatattc cattcgggta agggggagaa aagtttgtct cagcaatcga tacaaaaagt 1382761 attagtagca aacaggggag aaattgcaat ccgaatattc cgggcgtgta ccgagttgaa 1382821 tattcgtaca gttgcggtct attcaaaaga agattccggt tcctaccatc ggtacaaagc 1382881 ggatgaagca tacttggtcg gtgaagggaa aaaaccgatt gatgcttacc tggatattga 1382941 aggtatcatt gatattgcga aaagaaacaa agtcgatgca attcatccgg gatacggttt 1383001 cttatctgaa aatattcatt ttgcgagacg atgtgaagaa gaaggcatcg tattcatagg 1383061 gccaaaatcc gagcatctcg atatgtttgg tgacaaggta aaagcgcgtg agcaggcaga 1383121 aaaagcggga atccccgtga ttccgggaag cgacggtcct gccgaaacgc ttgaagccgt 1383181 cgaacaattt ggacaagcta acggttatcc gatcatcatt aaagcctcgc ttggcggcgg 1383241 cggccgcggt atgcggattg tcagatctga aagtgaagtt aaagaagcat atgagcgtgc 1383301 taaatcagag gcgaaagcag cctttggcaa tgatgaagtt tatgtagaaa aattaattga 1383361 gaatccgaaa catattgagg ttcaggtcat tggagacaag cagggcaatg tcgtccatct 1383421 ttttgagagg gattgctccg ttcaaagacg ccatcaaaaa gtcattgaag tggcgccgag 1383481 tgtctcgctg tcacctgaat taagggacca aatttgtgag gctgcagttg cgcttgccaa 1383541 aaatgtaaac tatataaatg cggggacggt cgaattcctt gttgcaaaca acgagttcta 1383601 ctttattgaa gtaaatcctc gcgtacaagt tgaacacacg ataacagaaa tgattactgg 1383661 tgtcgatatt gttcaaactc agatccttgt tgcccaaggg cacagccttc acagcaaaaa 1383721 agtaaatatt cctgagcaaa aggacatttt tacaatcggc tatgccattc agtcacgggt 1383781 tacgactgag gatccgcaaa atgatttcat gcctgataca ggaaaaatca tggcttaccg 1383841 ctcaggcggc ggttttggtg tccgtcttga taccggaaac agcttccagg gcgccgtgat 1383901 cacaccatac tatgattcac ttctcgttaa gctttcaact tgggctttaa cgtttgaaca 1383961 ggcagctgcc aaaatggtgc gaaaccttca ggagtttaga atcagaggca taaaaacgaa 1384021 cattccgttc cttgagaacg ttgcaaagca tgagaagttc ctgacagggc aatatgatac 1384081 atctttcatt gatacaacgc ctgaattatt taatttccct aaacaaaaag accgcggaac 1384141 gaaaatgctc acttacatcg gcaatgtgac agtgaacggc ttccctggaa tcgggaaaaa 1384201 agaaaaaccg gcgtttgaca aaccgttagg cgtaaaggta gacgttgatc agcagcctgc 1384261 cagaggaaca aagcaaattc tcgatgaaaa aggtgcagaa gggcttgcaa attgggttaa 1384321 ggagcagaaa tctgtccttt taactgatac gacattcagg gatgcccacc aatcgttatt 1384381 ggcaactaga atcagatcgc atgatttgaa aaaaatcgca aatccgacgg ctgcgttatg 1384441 gcctgaacta ttcagtatgg aaatgtgggg aggcgcgacc ttcgatgtag cctaccgatt 1384501 cctgaaagaa gatccgtgga aacgtttgga agatcttcgc aaagaagtgc cgaatacctt 1384561 attccagatg ttgcttcgct catcaaatgc ggtcggctat acgaattatc cggacaatgt 1384621 gattaaagaa tttgtgaagc aatcagctca atccggtatt gatgtgtttc gtattttcga 1384681 cagcttaaac tgggtaaaag ggatgacgtt agccattgat gctgttaggg ataccggcaa 1384741 agtggcagaa gctgcgattt gttatacggg agatatcctt gacaagaacc ggacgaagta 1384801 cgaccttgca tattatacat cgatggcgaa ggagcttgag gcggccggag cccatattct 1384861 cgggattaaa gatatggcag ggctgttaaa accgcaggct gcatatgagc tcgtttctgc 1384921 gttgaaagaa acgatcgaca ttccggttca ccttcatacg catgatacga gcggaaacgg 1384981 tatttatatg tatgcgaaag ctgttgaagc cggcgttgat atcatagacg tggcggtcag 1385041 ctcaatggcg ggattaacgt cacagcctag cgcgagcgga ttttatcatg cgatggaagg 1385101 caacgaccgc cgtccggaaa tgaatgtcca aggcgttgaa ttgctgtccc aatattggga 1385161 gtcggtgcgt aaatattata gtgaatttga aagcggaatg aagtctccgc atactgaaat 1385221 ttatgaacac gaaatgccag ggggccaata cagcaacctg cagcagcaag ccaagggagt 1385281 aggccttggc gaccgctgga acgaagtcaa ggaaatgtac agacgcgtga acgatatgtt 1385341 cggtgacatc gtcaaggtaa cgccttcctc aaaagtagtc ggagatatgg cactctacat 1385401 ggtgcaaaac aatctgactg aaaaagacgt ttacgaaaaa ggtgaatctt tagatttccc 1385461 tgattctgtc gtggagcttt ttaaaggaaa tatcggccag cctcatggcg gattcccaga 1385521 aaaactgcaa aagctgatct taaaagggca ggagccgatt acagtcagac cgggcgaact 1385581 gcttgagccg gtgtcatttg aagcgatcaa acaggaattt aaagagcagc ataacttgga 1385641 aatttcagat caggatgctg tggcatatgc cctttatcct aaagtcttca ctgattatgt 1385701 gaaaacgaca gaaagctatg gagacatctc ggtattagat acaccgacat tcttctacgg 1385761 tatgacatta ggtgaagaga tagaagttga aattgagcgc ggcaaaacgc tgatcgttaa 1385821 gctgatttca atcggtgagc ctcagcctga tgccacccgc gtcgtttatt tcgaactcaa 1385881 cgggcagccg cgtgaagtag tcattaaaga tgaaagcatt aagtcttccg ttcaggaaag 1385941 gctgaaagca gaccggacaa atccaagcca catcgcagct tccatgcctg gaacagttat 1386001 taaggtattg gctgaagcag gcacaaaagt caataaaggt gatcatttga tgattaatga 1386061 agcgatgaaa atggaaacaa cggttcaggc gcctttctca ggaacaatca agcaggttca 1386121 tgtgaaaaat ggtgagccga tccaaacggg agatctgctc cttgaaattg aaaaagcata 1386181 aaaaacaaag agtgtatatc aatgatatac actcttgttt tttatataga aaatgtggag 1386241 tgaaacagat ggttagaaga gatataaggg gacttcagag attatagagt actgtcacaa 1386301 gcccaaaata aaaagaggct tatacagcca atattttaga tgctttgtag tatgccgtgc 1386361 atatttcttt aagcactatc tgatttaaaa ggctttaata cttatgttcg cgagctatag 1386421 atccatatga aatttctata atcacgatga gaaaggggac agaccgaagt gagccgctca 1386481 ctgatcatca agttcggcga aggctggcga ttgaaacgca taaagcgcca aaaaacaaga 1386541 cataaaaaag accaaagccg cctaaggctt tggtcttgag tccttatgat tgcctggatt 1386601 cataacggaa acgagcaatc aataataaga agtagcatag aacgccaaac agacaggcaa 1386661 taaagaacga gtgggcaagt gcaaagccca gagccagttc agagtatacg atcataatac 1386721 cggacagtgc ctgtaatgta atgaaaataa gacatgagat ccatccccaa aagatctgtt 1386781 tttgatcttt ataggaagta atagcatgaa cagcggcaac aataatccat acaaataaaa 1386841 gtaaggctgc tgctctgtgg cccatttgca cccattcatg gaattgggtc ggaagtccat 1386901 tgttcagcgg gctgcacagc ggcacattag gacatgccag acttgattca gtgtgtctta 1386961 catatgcgcc tgtatacaca acgatatagg aatatattaa aattcctatc atgtgaaatt 1387021 gcatcttttt gccgatttga agcggcttaa ccagtgttct gactgattta tcagcttcaa 1387081 atatgagcaa tgttaaaata agcactgaag caaaagaaat taatgagatg ccgaagtgaa 1387141 gcgccataat cagcgcgttc gaaccgaata cgacagccaa tgcgccaagc aatgcctgaa 1387201 gaaataaaaa gataattgac atgatcgcga gaaacgttgt ttcacgaaaa atcggcgtga 1387261 tttttctcca tgaccaaaac gcaaggctta gcacaaggat aatagagatt ccgcttgcga 1387321 atcggtggct ccattcaata attgaagccg gattcagttc agggaaaaaa cggccgtgac 1387381 acagcggcca ctgtctgccg catccttggc cggaacctgt ttttgtaacg agggcacccc 1387441 cgattaaaac aattagcatg acaaatgtcg tcagaacacc gagagctttt aatgctttat 1387501 tcatacaata ttcaccttct taacatactg ctgcaatttt atatacgttc caagtgtaag 1387561 cgaatatgtg ttttgtggca attcccagag ccttttgttc acaaaaatat aatagaatga 1387621 cggcttctgg aaaatgtaca cttgattatt catgccgggt ctgatagaaa taaggtaaac 1387681 gcaatgccga tttggagatt gccttcatct ttggtaaaat tcataaaaag ttcacaaata 1387741 aattcctgtt tgtcgtttaa tatttaatag gatgtttttt tacaagatgt tatcttgtat 1387801 gatagagttg caggttattt tattctcctg cgttaggttt gtaagggagg tttacgttat 1387861 ggctaactcc agaatcttaa atgatacagc tatagacgga caaattgaag aaacaacggc 1387921 atggaaagat tttctgtccc ttattaaaat agggatcgtc aattctaacc tcatcacgac 1387981 tttcactgga atgtggcttg cactgcatat atccggttta agttttttag gcaatataaa 1388041 caccgttctt cttacgttaa tcgggtcttc actgattatt gcgggctcct gcgcgatcaa 1388101 taactggtat gaccgggaca ttgaccatct tatggagcgt acgaaagtaa gaccgacggt 1388161 tacgggtaaa attcagccga gtcaggcgtt atggtctgga attttgctgg ttgctttagg 1388221 attgatcatg ctgctgatga caactgtcat ggctgctgtt atcggtttta tcggagtctt 1388281 tacgtatgtt gtattgtaca caatgtggac gaaacgccgc tatacgatta acacagtagt 1388341 aggaagcgtt tccggtgcag tgccgccgct tattggatgg acggcagtgg aagggaatat 1388401 cggtgtcgta gcatgggtgt tattcatgat tttatttatt tggcagattc ctcacttctt 1388461 agcattggct attaagaaaa ctgaggatta cagagctgca aatattccga tgcttcctgt 1388521 cgtatacgga tttgaagtga caaaaagaca aattattgtg tgggttgcgt gcctgatgcc 1388581 gcttccgttt ttccttggta gcctgggtct tccgattgtc attctcggct tgctgttaaa 1388641 tatcggctgg ctgattcttg gcttaatggg attccgctcc aagaatatca tgaagtgggc 1388701 aacgcagatg ttcgtttact cgcttaacta catgacaatc tatttcgttg ccatggttgt 1388761 cttgacgctt ttctaaaaaa tagatatgat gcttgtttta tcgcttcaaa ataaacgatg 1388821 acaactagta aatgccgcct tgacctcttg tttaatcagg cggctttact tttatacata 1388881 gatggcattt tgagtaaaaa aactcataat ttaagagaag aggaaatgta agtgctttat 1388941 tggtgatagg ttggatggcg atagatttcg atccgctttc cgcctttgta ttgaccagaa 1389001 aaggggttgg gtgaaatggt aaagcattgg cgtcttattt tattattagc cttagtgccg 1389061 cttctattaa gcggatgtgg aaaacctttt ttatccacgc tcaagcctgc tggcgaggtg 1389121 gctgataaac agtatgacct gacagtgctc agcacattga ttatggtggt tgttgttgca 1389181 gtagtatctg ttatcttctt ttatgtgatt gtgagattca gaagatcacg ggtcggtgag 1389241 aacacgatac cgaaacaggt agaggggaat aaatttttag aaatcacatg gaccgtgatc 1389301 ccgattttgc tgctcattat tcttgtgatt cctgttgtat tatatacgct ggagctagcg 1389361 gacacatcac caatggataa aaaaggccgc aaagctgagg atgctcttgt agtcaatgtt 1389421 agggcaaatt tatactggtg ggagtttgag taccctgatt acggcattat cacaagccag 1389481 gagctgattg taccgacaga tcagcgtgta tattttaatt taaaagcctc tgatgtaaaa 1389541 cattccttct ggattccttc agttggagga aaacttgata cgaatacgga taatgaaaat 1389601 aagttcttcc tgacatttga ttcaaaacga agcaaagagg caggagatat gttttttggg 1389661 aagtgtgcag agctttgcgg cccttcacat gcgctgatgg attttaaggt gaagacgatg 1389721 tctgcaaaag aatttcaggg ctggacaaaa gaaatgaaga actataagtc tacagcagag 1389781 agcgatttgg ctaagcaggg tgaagaactg tttaaagaga aaaactgcct gagctgccat 1389841 gcggtagagc cgaatgataa gcgtgcagaa gccgctagaa cggcacctaa cttggcgacc 1389901 ttcggtgaaa ggacaaaagt ggcaggggtg aaagaggcca acaaagaaaa tgtgaaggct 1389961 tggctgaagg accctgacag cataaagccg gggaacaaaa tgacaggcac atatccaaag 1390021 ctctcagaca gcgaaacaaa tgcgctttat gaatacttaa aaggcttaaa agcggaaagc 1390081 aagtagggaa gaaagggaga tattggggga ggtcacatat gttgaatgcg cttacagaaa 1390141 agcggacgcg cggatctatg ctttgggatt atttgacgac ggtggaccat aaaaaaatcg 1390201 caattcttta tttagtggca gggggattct tctttcttgt cgggggaatt gaagcgatgt 1390261 ttatcagaat tcagcttgca aagccggaaa atgcgtttct cagtgctcaa gcgtacaatg 1390321 aagtaatgac tatgcacgga acgacgatga tctttctggc tgcgatgccg ctcttatttg 1390381 ccttgatgaa tgcggttgtg cctttgcaga tcggggctcg ggacgtttcg tttccatttt 1390441 taaacgcgct tggtttttgg ctcttctttt tcgggggcat tttcttaaat ctaagctggt 1390501 ttttgggcgg agcgccagat gcgggctgga catcatatgc ctcactttcg cttcattcta 1390561 aagggcacgg catagacttt ttcgtcctcg gactccaaat atcggggctc gggacgctga 1390621 tagccgggat taactttttg gccacgatta tcaacatgag ggctccgggc atgacgtata 1390681 tgaggctgcc tttgtttaca tggacgacat ttgtggcctc ggcattgatt ttgttcgcgt 1390741 ttccgccgct tacggttgga ttggctctca tgatgctgga tcggctgttc ggaaccaatt 1390801 tctttaatcc ggagcttggc ggaaatacgg tcatttggga acatttattt tggatcttcg 1390861 gccacccgga ggtttatatc ctaattttgc ctgcattcgg tattttttct gaggtcatcc 1390921 ctgtgttcgc cagaaagcgt ttgtttggct attcttcaat ggtttttgca atcgtgctca 1390981 ttggctttct gggctttatg gtttgggtgc accacatgtt cacgactggt ctcggcccga 1391041 ttgcaaatgc gatttttgcg gttgcaacaa tggctatcgc gattccgacc gggattaaga 1391101 tttttaactg gctgttgacg atttggggag gaaatgtgaa gtatacaacc gctatgctgt 1391161 atgctgtctc atttattcca tcctttgtgc tcggcggtgt gacgggagtc atgctggcag 1391221 ctgctgcggc tgattatcag tttcatgata cgtattttgt ggttgcgcac ttccactacg 1391281 tcattattgg cggcgttgta ttcggccttt tagccggtgt tcatttctgg tggccgaaaa 1391341 tgttcggtaa aattctgcat gaaacgatgg ggaaaatttc atttgtattg ttttttatcg 1391401 gctttcacct cacgtttttc attcagcatt ttgtcggctt aatggggatg ccgcgccggg 1391461 tttatacgtt tttgccagga cagggtctgg aaaccggcaa cttgatcagt acaatcgggg 1391521 cgttttttat ggcggcagct gttattcttc tgctggtcaa tgtcatatgg acatcggtaa 1391581 aaggtgaata tgtaggtgct gatccatggc atgacggacg tacgctggaa tggaccgttt 1391641 cttcaccgcc gccggagtat aactttaaac agcttccttt tgtcagagga cttgatccgc 1391701 tttggatcga gaagcaggca gggcacaaat caatgacgcc ggcggaaccg gttgatgata 1391761 ttcatatgcc aaacggctca atcctgccgc tcatcatttc cttcggcctt tttgtcgcag 1391821 cgttcgggct gctgtacaga agtgattacg cttggggcct gccggtgatc tttatcgggc 1391881 tcggcatcac atttattacg atgctgcttc gttcagtaat tgatgatcac ggctatcata 1391941 ttcataaaga ggaactgccg aacgatgata aaggggtgaa ggcataatgc aagttcaaga 1392001 aaaattcacc gcagaaacct ttccagcttc tcctgaaaaa gtaaccctgg aagggaaaaa 1392061 taaattttta ggcttttggc tttttcttgg cggagagact gttctgtttg cgtctctctt 1392121 cgccacgttt cttgcgcttc ggaattcaaa tgccggtgat ccgcctacga cggaaatgtt 1392181 cgatgtgaca cttgtattca ttgccacaat gcttctatta acgagcagtt taacgagtgt 1392241 gtacgcgatg taccacatga agaacttttc cttcggcaag atgcagcttt ggctgggaat 1392301 tacgatttta ttgggggcgg gctttttagg actggaaatc tatgagttca agcattacac 1392361 ccatgaattt ggctttacca tcacaagctc tgcccttggt tctgcgtttt acacgcttgt 1392421 cggtacacac ggcgcccacg tggcatttgg gcttatgtgg atcagcacgc ttatgatccg 1392481 caatgccaag agagggctga atctgtatac ggcgcctaag ttttacgttg ccagccttta 1392541 ttggcacttt attgatgtcg tgtgggtctt catctttacc gttgtatatt taatggggat 1392601 ggtgggataa acatggtcga taaaaaaagc agagggcata tcaatagcga ccttgaattt 1392661 aagaaaaaaa agcatgcccg ggagatgaaa tatcaagtcc tgtcttttgg tttaatgatc 1392721 ggtcttacga ttgttgcatt tctgactgtg gccacggacg gtgtcggcag ctggtttacg 1392781 attcctttca ttattttgct agctgcaatt caagtcattt ttcagctgta ttatttcatg 1392841 catatgaatc agaaagggca tgaggcgccg gcactgtttt tgtattcagg ggtgtttgtc 1392901 gcgtttatca ctgtgcttgc gtttgtgaca attatatggt ggtaatttga acagccgccg 1392961 gaggtgaaga aatgaatcag ttggagatat ttgggtttcg cgcgatgtgg agcccttatc 1393021 ttttttgtat cctgttaggc attacggcgc tttatctcta tttttacagg cgaatgtctt 1393081 caaagccgaa tcgaataact ggtaaagaga tggtgtgctt tctgtcggcg atgctgtttt 1393141 tatatgcagc cgagggaagc ccggttgatc tgctcggaca tattatgttc agtgcgcata 1393201 tggtgcagat ggccgtcctg tatttggttg tcccgccgct gttaatcgcg gggattcctg 1393261 catggctctg ggaaaaaatc attttcaggc cttcaatcaa accggttttt tcctttttta 1393321 cgacgccttt aattgctttg cttttgttta acggcatttt ttctttatat catgtaccgc 1393381 ttatatttga tactgtcaaa acagatccgt tttaccatac attaatcact tggcttatct 1393441 ttgtgcttgc gttcttcatg tggtggccgc ttgttcataa ggttgagcgt ctacggcagc 1393501 tcagcggctt gatgaagctg ggttatatta tggcggacgg tatgctgctc acacctgctt 1393561 gcgccttgat catgttcagc ggtgcaccgt tatacgccac ctatacagat ccggctttat 1393621 gggctgaggc aatgaggctt tgcgtgccag cggatatgat ggggcaggtc ccattaacag 1393681 ggccagagat gttgaataca ctgcctttgt tagaggatca gcagctcgga gcagtcatga 1393741 tgaaaatcat tcaggaaatt gtgtacggta cttttttggc cgttattttt ttccaatggg 1393801 tgaagaaaga aagggaaaag gacgggcagg aggagccgcc gtatattcag cagacgatat 1393861 cataaaaggt acagcgaaat atgctgtacc ttttcgttac atttgaactg tttttaacat 1393921 gttggctatg tcctgaatca gtgccttgct ttttgtcaca acctgtacgg gaaactcttc 1393981 cgtttctcca tattctactc catgagggta gtaatgcttt cctaggagag gggacattaa 1394041 ttgaatcacg gcgcgcccgc ttccgacatc gccttctgcc gcaatacctt gtatccgcag 1394101 gtaaaacgta ccctcaatcg tcgaaaactt cttgtcatag gtgactctct cgtaatccca 1394161 ttgacccgct ctgataagac ctttgctttc cattaagtcg tctagccagc tgagctcagc 1394221 cttaacccct tcaagtccgc tttcagtaaa cttcaacact gacccctcct tataaaaatt 1394281 acctttcctg acaatcatag tatgaaagcg ttaaactttc aatgaatctt cttcttttga 1394341 aagtatgcaa aaattaaatt ttgacgacaa tagcactaga ctaaaggagg ttaaacggat 1394401 gacaaaaata aaagatctga tgacagccga cttgcaatat tgcacggtat tagataatgt 1394461 atatgaagct gcagtaaaga tgaaggacgc aaatgtagga gcgataccgg tagttgatga 1394521 ggacggggaa acattggtcg gcatcgtaac cgaccgcgat ctcgtattaa gaggaatcgc 1394581 catcaaaaaa ccgaactcgc aaaaaatcac tgacgcgatg actgaaaaac ctgtcagtgt 1394641 ggaggaagat gcttcagtcg atgaggttct tcatttgatg gcatcgcatc agctcagaag 1394701 gataccagtt acaaaaaata aaaaactgac tggaattgtc acgcttggtg atctttcttt 1394761 atctgagcaa acgaatgaac gtgccggcag cgccttatcg gatatttccg aaggggataa 1394821 tagagaagaa ggcttttttc attaacacat aaatctttga catgttaaat aggctgtatt 1394881 gtaatgggat gtaaacaaga gattgtgaat cgccacgggg gtgatagatt gaaaaatata 1394941 ttgagagcaa tggttatcct tttgattatc tgcggaacct atgttctgtt tattcaatat 1395001 ggatctgttc ctgaaaagaa atcaaatgac agcgagcctc aggtgtcgaa tgaggaagcg 1395061 caaagcggca aacgaataca tatgccgact tcagggttat tgtccttcat gggcaagcac 1395121 gccgatgaag taacgaaaaa gcttggggaa cctgaacgta ttgacccttc ggcttatgat 1395181 tacgattggt gggtatacaa tcaaggtaag gatcaatata tccaaatcgg ggtattaaac 1395241 aataaagtgg tcacattatt cgcgtcgggt aatgatatta acgccaagcc tttcaaaatt 1395301 ggagaatcaa ctggcgaagt attcaagacc acccaggtgg caccatttgt gaatgtagag 1395361 tataaaggaa attcctatcg gtttgaattt tctgaagaag atatcaatac aagaccgact 1395421 gtaaaggtag gaaagatgta tgtccagctg tatatggaca aatttgaggg gaagctatcc 1395481 agcatcaggg cgtttgatgc gcagaccttt gtaaagcaaa gaccttatga ggtagtgtac 1395541 cgcggggaat taattaaacc gaaagccgtt tcagatgaga aatggaaaaa gatccaaaca 1395601 acgagcgaaa agcaaatcct tgatttgacg aatgtcatac gcgttaaaca tggacttgcg 1395661 aagcttgagt gggatcagcc aacggcggaa gtggcatttg ggcatagtga ggatatgaag 1395721 gaaaataatt atttctccca tgtctctaaa aaatacggct cgctgaaaga ccgcttagaa 1395781 gaagggcatg ttgattttca gcaagcggga gaaaatatcg catacaatta tgtggacggt 1395841 ccggctgctg tagaaggctg gctgaatagc gaaggccatc gaaaagcgct tctgaattca 1395901 gattatacgc atcttggtgt cggagtagac cggaaatatt acacccaaaa ctttattaag 1395961 cgatggtaat gaaagccgcg gacgaatggt tcccggcttt ttctatttcc atacaagctg 1396021 gtctgaatga atgtgctgat agcttacaga taaggccgtt tcccatccct tcagtcaggc 1396081 tttttcacca gtgtataggg atatcgctaa aaattcattt gggaatgaat ataggcgaac 1396141 acaatgcccg acaaaacgat acattgtagt aggtaacgat tttcggaggg ggtgaggatt 1396201 gtggcgaatc aacatgccaa tcattcaatc aatgacttta aacaattcgt caaaaagcat 1396261 cccaagctga taaaagaagt gcgcaaagaa caaagaagct ggcaggacgt atatgaaaat 1396321 tgggtcctct tcggggagag cgacccgatt tgggatccat atcgggaacc ggaagaagct 1396381 tctgaagctg tgcctgaaac accgcaaaaa aatgattttg tctcgaaaat ggtgacagcg 1396441 gtgaaaaaga tggatgtcaa tcaaatgaac gaacaaatca ataaaatgag ccagtcgatc 1396501 tcatcgttgc aaagccttct taatacattt tccggaagcg gacagaagca ttctcagcca 1396561 ggctctggac agcatccttt ttcttttcga aaggattaaa aaaggggagc tcatatgcgc 1396621 aaagaggttc aggaatatat tttagcaaac gaagaacgga aacgattcat cagagaacag 1396681 ccgatatggt accgcaggct ttcaagaaaa ccggatgatc tgtcctcctt tcagcttgaa 1396741 atgatgaatt tttatgaaaa aaccattccg catcgggtga atcagtttac gaacgggatt 1396801 caaatggcgc aaatgatgat gcaaatgttt caagcgatgc ggacaaaaga ttaaaaggcc 1396861 ccgaagaagg gtcttttttc atgcggtcat aaggttttgt tggcggctgc ggttaagcat 1396921 tttccaattg gctggtttca tggtaaacta acaactggag gtgcatgtta tgtatgcgac 1396981 gatggaatcc gtgcggcttc aaagtgaagc tcagcagctt gccgagatga ttctgcagtc 1397041 ggagacggct gagaactacc gcaattgtta caagcgtctc caggaagatg aagaggcagg 1397101 tcggattatt cgttctttta tcaaaataaa agagcagtat gaggatgtac agcgttttgg 1397161 caaatatcat cctgactata gagaaatatc ccggaaaatg agggagatca aacgtgagct 1397221 ggacctgaac gataaggtgg ctgacttcaa gagagctgaa aatgagctcc agtccattct 1397281 tgatgaggtc agcgttgaga ttgggacagc tgtttcggag catgtgaaag ttccgactgg 1397341 gaacccttat tttgacggtt tgtcttcatg cggaggcggc tgcggttcag gcggaagctg 1397401 cggatgtaaa gtgtcctgac gagactggcc gtctcgtctt ttacatataa gagaaaacag 1397461 gcaggtgatt gtattggaga ataggcgcca gggcatggtt gtgtatctgc actccctaaa 1397521 gcagagcaaa atgctgagga agttcgggaa tgtgcactat gtatcaaaac gattaaaata 1397581 tgtcgtactg tactgtgata tggaccaaat tgaaaaaaca atggacaaga ttgcgtctta 1397641 ctcatttgtg aaaaaagtgg agccttctta taaaccgttt ttaaaattgg aattcgagtc 1397701 aaagcttgat aaggcaaaag aatacgatta taaaatcggc atatagctat aaaaaaatcc 1397761 ccgcaggcat ctgcggggtc cttctattcc ttaatatgtt aaggagaagg caaagggaga 1397821 ggagaaaccg gaggaagaac ttatggggaa acgtaagtct tctccgcggt tggcaacaac 1397881 atcctctaga tgctgttgct tatagtatgg acaaggatca tgctgcctat acacctgttt 1397941 atcaagatta gcgttcattg tttggaagaa tgctttatgt taagatagga ttgatttttt 1398001 tctatgtaca tagcggcgtc cggccgaata aagaaacaaa atagctttta gaaaaagtgg 1398061 tgtggaacat gagagtaatt tctggatcaa aaaaaggccg ttcactaaag gctgtagccg 1398121 gaacatcaac aagaccgaca accgacaaag tgaaggaatc cattttcaat atgatcggcc 1398181 cttattttga cgggggcagg ggacttgact tattcgcagg gagcggaggt cttggaatcg 1398241 aagcgctttc acgcgggttt gagcattgta tattcgttga ccgtgatttt aaagcgattc 1398301 aaacggtaaa atctaatttg aaaacgctgg agcttacaaa acatgcacag gtataccgca 1398361 atgatgcgga acgtgctttg cacgctgctg ctaaaagaga aaccggcttt cgcggaattt 1398421 ttctcgatcc gccgtataag gaacaaaagc tgaaagcact tttaactttg attgacgaat 1398481 atcaaatgct ggaagaagac ggctttatcg tcgctgagca tgacagagag gtcgagcttc 1398541 ccgaaaccgt aggagatctt gtgatgacaa gaaaagaaac ctatgggtta acaggtgtag 1398601 cgatttataa aaagaggggg tagtgaggtg gcgagtatag ctgtctgtcc cggcagtttt 1398661 gatcctgtga cctacgggca tctggacatc atcaaacgcg gggcgcatat ttttgaacaa 1398721 gtgtatgtat gtgtgctgaa taattcttca aaaaagcctt tgttcagtgt ggaagaacgg 1398781 tgtgagcttc tgagagaagt cacaaaagac attccgaaca taacagttga aacatcgcaa 1398841 ggcctgttaa ttgattatgc aaaaagaaaa aatgcgaaag cgattttaag aggcttgaga 1398901 gctgtatctg attttgaata cgagatgcag gggacatcag taaaccgggt gcttgatgaa 1398961 tctattgaga cgttttttat gatgacaaac aatcaatatt cgtttctaag ttcaagcatc 1399021 gtaaaagaag tggcaagata caacggctcg gtatcagagt ttgtaccgcc ggaagtagag 1399081 ttggcgcttc agcaaaaatt cagacaagga tgagggtttt gactcatcct ttttttgttc 1399141 cgtttgtcag tctgtaagaa aaaatgataa tgtacgtaaa cagcgcgcat agtgtgacag 1399201 caggtccgat ctgcacaagc agattccagc cgtttataaa ggcagttgac atgtcactgc 1399261 tgttaagaga tttaaataca tactgatacg gatcatgcca tgctgtgtaa agaggtttcc 1399321 ataaaagcat gacgaagaca gcggcataaa cgccctgcag caaacgtgcg ataaagaatg 1399381 gtttaaatct aatgtcggtt tccgataaaa tacctgccac ctgagcttgt acggaaaagc 1399441 cgctaaaccc aagaataaag ctgacgataa tggctttttg cagaagagaa acatctgtct 1399501 cgctgacaag cttgctgcct aatgtaattt caaacatccc tgataaaagc ggaatgtcca 1399561 attgagtcgg aagctgaaac aaagtcagtg ctccttttgt gaaaacagac aaaacatcag 1399621 tcagctggac cactgacaac agccgattga agacagaaaa taaaataata aagccgccta 1399681 ccataagaag cgtttgaaca gaagacgtca cggcgtcgcc taaaatttta cctaagggcc 1399741 gtttttctgc aagtctggcg gtatgaagag cgtgtaaagc atctttgact gaagggaaag 1399801 gtatcgtttt ctttcttctg agatgctgct cttccttgcg gccataggag cgcattgtta 1399861 aaccgacggc aagattcccc aaatagtgtg cagaagctaa taaaatgcct agtgatgcgt 1399921 tttgaaagaa accgacggca acagcgccga aaataaagag cgggtttgaa gaattggtaa 1399981 acgacgcgag ccgttctgcc tctactcttg aaatctgatt ttcctgccgc agacgggcag 1400041 tgagttttgc gcccgctggg tttcctgatg ccattcccat agcaagaacg aagccgccga 1400101 cacccggcac gcgaaagatc ggccgcataa aaggctcaag caaaacaccg acaaaccgca 1400161 caatgccaaa gccgattaag agttcggaca gaataaaaaa tggcagcaat gacggaaaca 1400221 caacctccca ccacatagac agcccggttt tagaggcttc gaatgaggcc tgtggatgtg 1400281 agatgacagt cgctgttaaa aaaagaaaaa acgaggcaat caaaagtgta ttaatcttcg 1400341 acaagttcat tcttacctcc ccgatgctaa aaatgcccaa tgacatgtat atcatgataa 1400401 aataatgtat gatgtaaaac ggccaagcag tacctgtcct cttgattctt tgtactaata 1400461 tacgagcata ggggttcagt ttagaccata gaattcggta tacagggaat tcaggcagga 1400521 ggttaacgct ttggccaaac ctaaaatcgg gttagcgtta ggatcgggag gggccagagg 1400581 gcttgctcat ctcggtgtgc tttccagttt acataagcac caaattgaag tggatatgat 1400641 tgcaggaagc agcatgggcg ctttggtggg cagtttttac gccgccggac atgacgtggc 1400701 aacgatgaaa aaagtagcca aagcctttaa acgaaggctt tatgctgatt atacggtgcc 1400761 gaaactcggt tttttaaaag gtgaccgcgt cagacagctt gtgcatgctt atacattcgg 1400821 aaaaccgatt gaagagctcc aaatcccgct gggcattgtt gcgtgtgatc tacagacggg 1400881 agaaaagatt gtgttccgaa aaggatcagt gtcagatgca gtgagggcca gcatcagcat 1400941 cccgggtatc tttattccgc agcggctgga cggacgcctt cttgtagacg gcgcggtcgt 1401001 cgatcgaatt ccggtttctg ttgtgaaaga catgggagct gatattatca tcgcttcgga 1401061 tgtttccagg gttcgaaaaa ctgaaacagc agtgcatatt tttgatgtga ttatgcaaag 1401121 tatggatata ctgcaaaatg aattagtgcg gcatcaaaca attgccgcag atatcatgat 1401181 tcgcccttcc cttgaaacat acagctcaag ctcgtttgcc aatattgaag aaatgatatc 1401241 ggcaggcgaa gaggcgacaa accgaatgat cagcaagata agaaaagaaa tagagaattg 1401301 ggagggctca taatttgcta cgtaaaaaac attttagctg gatgctcgtc atcctcatac 1401361 tgatcgccgt tttatcattt ataaaacttc catactatat tacaaaaccg ggagaagcga 1401421 cagagcttgc ttcattgata aaagtggagg gaggctaccc ggaaaaagga agtctgtcct 1401481 taatgactgt taaagtggga ccggctaatc catttacata tgtgtgggca aagatgcacc 1401541 cttattatga aattgttcct gatgagagca ttaaggagga aggcgaatca gataaggagt 1401601 atatgaaaag acagctccaa atgatgaaaa gctcgcaaga aaatgcggtt atagccgcct 1401661 atcaaaaggc aggaaaaaaa gtcagctatt cctttaacgg catatacgca agctcagttg 1401721 tagaaaacat gccggcaaaa gggaaaatag aagtcggtga taaaatcatc agcgcagacg 1401781 gcaaaaacta tcagtctgct gaaaagctga ttgattatat cagcagcaaa aaagcgggag 1401841 ataaagtcac gttaaagatc gaaagagaag aaaaagaaaa gcgtgtcacc cttacgttaa 1401901 aacaatttcc tgatgagccg gatcgggcag gaatcggagt ttcgctttat acagacagaa 1401961 acgtgaaggt agagcctgat attgattttg aaatcgaaaa tattggcggc ccgtcagcag 1402021 ggttaatgat gtcccttgaa atctataatc agctgacaaa accagacgaa acaaaaggct 1402081 acgatattgc gggaacaggt acgattgatg ttgacggaaa agtaggcccg atcggcggca 1402141 ttgatcaaaa agtcgtcgcc gcagacaaag ccggaaaaga cattttcttc gcgccaaatc 1402201 aaaacggcgc cagcaattcc gattataaga acgcagtaaa aacagcaaaa gatattgatt 1402261 caaatatgaa gattgtgcct gttgatacca tgcaggatgc gattgattat ttgaataagc 1402321 tgaaagcgaa aagcacctga ttctcaggtg ctttttctat acatttaaaa agtgttgttc 1402381 atcttcgtca tatcgaatcg gtgcatgtcc gtattcctgt aggtcaaact cagttctcag 1402441 cggctcttct atcggcaggc tgtaaatcct gcttgctttt acgtccagat cgagagctgg 1402501 atgggagaaa gaggacagtt tgctgacaag cggaacagac agtgcttttt tcttttcgga 1402561 taaataagcc tgtccttttt tcgtcatgcc gagaagcctg atatacggcg ccttatcgtt 1402621 gtcaagcagc ttttgcatat cctgtttttt tgttctggtt aaaatgtgtg tattcatccg 1402681 ctggagcctt gtccacgtat agcgttttgt tttcagcagt tccataaatt cctgatagga 1402741 gctggatttt ctgatcgaac gaataattct gtgctctaaa ccttcctcca cctcgtatac 1402801 ttgctgtaat tcccgtgccg ttacagttga aaggctgtat tttaagtaag aaaagtagct 1402861 ttcaggtgta tgccacaatc cgaaagattt gcggtaagct gctaattcac gtgcagatgc 1402921 agcagggaga aaacgaaggc aggcttcgag attctggcca atcatcgctt ttctaatgct 1402981 tgtggcactt gctatatggt tttcgccttc agggagatcg gcatcatgat agtccgaaga 1403041 gattcgtgcc gtagtataag gtttcatagg atatcccccg gttagaatcg aggtcacata 1403101 ctggtatccc aaaatgttat ttggttttga caagtcaagt gcactttcag tatgcaaaat 1403161 ggagctgaag gcgatagccg ccgctgctgg gtaactggcc ccctttttaa gttcttcttt 1403221 aattcggtca ttcaatatat gtttatgctc atcaataagc tgtgctgttt ctaaaaaagg 1403281 cttgatatcc ccattttcac tcccgaaaaa cagcgcctca cattcaagtt cgttcaggat 1403341 ggaaacactg ccgcgtgcaa aaatgtctgc tttttgcacg gcataaagat aaggcagctc 1403401 aatgacaaga tcaactccgc tttgcagcgc catttttgtt cgggcccatt ttgatacaac 1403461 agcgggttcc ccgcgctgta aaaaatgtcc gctcatgacc gcgacagccg tgtcacatcc 1403521 ggtttgcagc tttgctgttt gggcatgata aaggtgaccg ttatgaaagg gattatattc 1403581 aaccaccaat ccgacagctt tcatattttt tccgcctttc ttgctatgtt taaaaacgta 1403641 tggtacattt gcaaatgaaa actcttacgc cttatttttg ttttaagtgt atgcatagca 1403701 tattccgctg tcaacgatac ttcaatggca gcattatgct gtaaagaaaa aatattgaca 1403761 aaaacaatct taaaagctat aatcatgttt gttgctttcc tgaggtgata caaatgaaat 1403821 ggacgattta tcagctgcat caaatgccaa aacaaagttt tgagtttgat gaaacagttg 1403881 agttaaatga gctgacaaag ctgaattctg acattcgccg catttctccc gttcgggtga 1403941 agggcagagc ggatatcaaa tccaaacagg tttcgtttga ttttacaatt tcaggcgaaa 1404001 tgcttttgcc atgctcaaga acactcgttg atgttccgta tccatttgaa atttcaacaa 1404061 aagaactgtt tatatttcat cacacggatg atatagaaga tgatgacgtt cacattgttg 1404121 aggacgatac tatcgacata actccgatcg tgaaagaaga aattctttta gaaatcccta 1404181 tgcaaatctt ttgtgaatct gaacaagaaa aaggagctgc tcctcaagaa ggaaaggatt 1404241 ggcaagtcat ttcggaagaa gacaagaaga atcaagttga tccgagactt gcagcccttg 1404301 aaaagctctt aaaacaagat gatgaatctt aactctttaa ggaggtggga ataatggctg 1404361 taccttttag aagaacttct aaaatgaaga aaagattgcg ccgtacacat ttcaaactta 1404421 atgtacctgg tatgacagaa tgtccgtcat gcggagagat gaagttgtct caccgtgtat 1404481 gcaaagcatg cggatcatac aacggcaaag acataaatgt aaaaagtaac taatgagaaa 1404541 agcgcagggt gaaagccctg cgctttttct ttttctcttc ctgtcagctt gcggaaaatt 1404601 tgtgagtgca aatagtctat ctaatctatt accggcatat gtatgagata aataagctga 1404661 catggaggga gattgaattt gaccattaca agacaagatg cttggactca ggatgaggat 1404721 ttgctgctgg cagaagtggt gcttcgtcat attcgagagg gaggaacaca gctttcagcc 1404781 tttgaggagg ttggaagggc gctgaccaga accgcggcag cctgtggttt caggtggaac 1404841 tcgtatgtga gaaaacaata ccagtcaggt atagagcttg caaaaaagca aaggaaagaa 1404901 ctgagaaagc aaatcggcgt tcattcggtc aatatgccga attccatgaa gcagactgcc 1404961 tcggcatcgt cagaaggaaa acgagatttg tccattcagg atgtcattca atttctcgaa 1405021 caattcaaag aaacaccgtc tgcacaagaa tttcagcttg aaagggaaaa attgaaggag 1405081 caaatccaat cgctgcaaaa agagcttgag gatttgcgga gtgaaaatca gacattgcgg 1405141 aatcagctag agatgacaga agaggattac aaggcactga tcgatatcat ggatcgggcc 1405201 agaaaaatgg ttgtttcgaa ggaagacgga agaatgaaaa aagcggctca agaaacgtaa 1405261 agaaacgcct gaaatgaacc ggccctatag taagaatagg ccggttgttt tgatttctat 1405321 gcagactctc ccggtgtcat ttcgcgatcc atatcaggat gccagatgag cgggttttcc 1405381 cctttgtccc gcgccatatc atacttaaca gttttaaagt tcattttgtt ccaaaattcc 1405441 gctgatttca ttctcggatt tgtccggatc ggcattttga atgattttgc aaattcaacc 1405501 aaggctctcc cgtatcccct gttctggtag cccggaagaa cctcaagctt ccacagctcc 1405561 aaataatcct ggcggttgtc aaaataggga ttcgatttgc cgttaacttg atacagactc 1405621 attcgtgcta caagtttatc gccaaaataa atcccgtaaa aaggcgaggt gctgtcattt 1405681 tcaataatat tatcctgaag ttcttcaagc attgaaagct cctgaatgcc gtattctttg 1405741 aatttcttga attcttccag cgttttatag ttgataagca gacgttctac ctttgtcaaa 1405801 caaatctccc cctttgttgt ttctacatat attgtaaacg ctttatttaa aaaatccaaa 1405861 tatttaaact ttaattttaa gcacatggga tctttgagaa gtaatttctt cttacttctg 1405921 ctatgataat acgtaaatgc taaattgggt gtgacatcat gaaaattgga attatcggcg 1405981 gaggctccgt tggtctttta tgcgcctatt atttgtcact ttatcacgac gtgactgttg 1406041 tgacgaggcg gcaagaacag gctgcggcca ttcagtctga aggaatccgg ctttataaag 1406101 gcggggagga attcagggct gattgcagtg cggacacgag tatcaattcg gactttgacc 1406161 tgcttgtcgt gacagtgaag cagcatcagc ttcaatctgt tttttcgtcg cttgaacgaa 1406221 tcgggaagac gaatatatta tttttgcaaa acggcatggg gcatatccac gacctaaaag 1406281 actggcacgt tggccattcc atttatgttg gaatcgttga gcacggagct gtaagaaaat 1406341 cggatacagc tgttgatcat acaggcctag gtgcgataaa atggagcgcg ttcgacgatg 1406401 ctgaaccaga ccggctgaac atcttgtttc agcataacca ttcggatttt ccgatttatt 1406461 atgagacgga ttggtaccgt ctgctgacgg gcaagctgat tgtaaatgcg tgtattaatc 1406521 ctttaactgc gttattgcaa gtgaaaaatg gagaactgct gacaacgcca gcttatctgg 1406581 cttttatgaa gctggtattt caggaggcat gccgcatttt aaaacttgaa aatgaagaaa 1406641 aggcttggga gcgggttcag gccgtttgtg ggcaaacgaa agagaatcgt tcatcaatgc 1406701 tggttgacgt cattggaggc cggcagacgg aagctgacgc cattatcgga tacttattga 1406761 aggaagcaag tcttcaaggt cttgatgccg tccacctaga gtttttatat ggcagcatca 1406821 aagcattgga gcgaaataca aacaaagtct tttgagcttt ttcggtaaca tgctatactc 1406881 atttcggatc actaactatt tattggagaa aggaagttct agaagatgca gctaactgaa 1406941 ctttccatca aaaatcagaa tgtgtttgta cagcactata tagatggcaa agaagaaatg 1407001 tcttcttttt ttgattacag tattcatcat aaggacatgt ggcgcgaaag actggaagac 1407061 ttatcttccc ggtttttcgc aagagaggaa ttggcggcgt acttaacctc ttaccataat 1407121 aaattcggtt caagtgcgat gcagtctgct attgagaagc tgaaggaccc gtcaagtgcc 1407181 gctgtagtcg gcggacagca ggcaggactt ttaacaggac cgctttacac catacataaa 1407241 atcatttcaa tcattgtttt agcaaagcaa caagaaaagg aactgcaagt gcctgtcata 1407301 ccaatcttct gggtggctgg agaagaccac gatttggatg agattaattt tgttcacaca 1407361 tctgaagaga atgggcctgt gaaaaaaaag ctgcctcagt cttattggaa gaaatcatca 1407421 gcagcgagta catcgcttga tcaggaaaag tgtgccgcgt ggatagatga tgtttttgcc 1407481 gcttttgaag aaacagacca tacgaataca cttctcgaca atgtgaaacg atgtttaagg 1407541 gaatctgtta cgtttactga cttctttgaa ctgctgatcg cggatttgtt ccaagaagag 1407601 ggcttagttt tattaaattc tggggatccg gggattaaaa agctggaaac ggccatgttc 1407661 caaaagattc ttcgagaaaa tgatgaactc gcccgggctg tatcagatca gcaggccttc 1407721 atgcgtcaag caggctacaa accgattatc gagtccggaa aagagcaggc gaatctgttt 1407781 tatgaatacg aagatgagcg ttttttaatt gaaaaagata acggccgatt tgtcatcaaa 1407841 gagcttgatc taggatggac gagggatgaa cttcatacac atatggaaga acatccagag 1407901 cgtttcagca acaatgttgt aacgagaccg ttaatgcagg aatttctcat tccgacttta 1407961 gcatttattg cagggcctgg ggaaatcaat tattggggcg agctcaaaca ggcatttgcg 1408021 gtgatgggct tcaaaatgcc tcctgtcatg ccaaggctga acattacgat acttgagcgg 1408081 catattgaga aaaaactggc tgaacggaat atctcattac aagacgcgat tgagcgcgga 1408141 acggagaatc aaagagagac atacttcgag cgccagattc cggaagagtt tacggcggtg 1408201 atggatcagg cgaaaagcca aattgaagcg attcacaaaa cggtccggca ggaggcgtta 1408261 aaggttgatc aaagcttgga acctttactt ctgaaaaatg ccgcttttat tcaggatcag 1408321 cttcaattct tagagcgcac ggtgatgaag cgaattgaag aaaaagaagg ctacgtcttg 1408381 aaggattatg aaagaattca aaatagcatt aagccgcttc ttgcgccgca agaacggatt 1408441 tggaatatca tgtattattt gaacaggtac ggtccaaaat tcttcacgac attcaagaat 1408501 ctgccatttt cttttcaaaa tcaacatcaa gttgtcaaac tttgaaataa agttttaaag 1408561 aaccctgact agttcagggt ttttttttat gggtaaacag tgtaaaatga agttgtggag 1408621 cgaagtggtg aatagtggtg agttaaggag agaaagtggg gcaagagatc atgtttatgg 1408681 gtgaatatca gcataccatc gatgcgaaag gccgcatgat cgtacccgct aaattcagag 1408741 aaggcctagg tgagcaattt gtgctgacta gaggacttga ccaatgtctc ttcggctacc 1408801 ctatgcacga atggaaacaa attgaagaaa aactaaaagc tcttcctctc acaaagaaag 1408861 atgcccgcgc gtttacccgt ttcttctttt caggggcgac tgaatgcgaa ctggataagc 1408921 aaggcagggt aaatatcgca tcatctctat tgaattacgc caaactggaa aaagaatgtg 1408981 ttgttatcgg ggtttctaat cgaattgaat tgtggagtaa agtaatttgg gaacaataca 1409041 cagaagagca agaagattca tttgctgaaa ttgctgaaaa catgattggg tttgatatat 1409101 aatgattctt cgtgtataac actctaaaaa caatttcaat tcatcctgat aaaaggtggg 1409161 accaacacaa tatgtttcaa cacaagacag tacttcttcg tgaaaccgta gacggactta 1409221 atattaaacc agacggtaca tatgtagact gcacactcgg cggagctggg catagtacat 1409281 acttattgca gcagttatcc gagaaggggc gtttaatcgc ttttgaccaa gatgatacgg 1409341 cattacagca tgctaaagaa gtgttgtccg attataaagg acagctcatt ctgattaaaa 1409401 gcaatttcag gtatttaaaa gaatatttga atgaacaagg cgttacagaa gtagacggca 1409461 ttttatttga tttaggggtg tcctctccgc agctggatac accggagcgc ggattcagtt 1409521 accatcatga cgcaccgttg gacatgagga tggaccagtc ggctacgctt tcggcgaaag 1409581 aagtcgttaa tgagtggcgc tatgaggatc tcgtccgtat tttctttaaa tacggagaag 1409641 agaagttcag taaacagatc gccagaaaaa ttgaggaggc aagaatgaag tctcctattc 1409701 aaactacggg ccaactggtc gatctaataa aagacgcgat tcccgctcca gcgagaagga 1409761 gcgggggaca tcccgctaaa cgcgtgtttc aggcaatcag aattgccgta aacgatgaac 1409821 ttagggtgtt tgaagaagct ttggagcagg caattgaggt tctgaagcca gggggcaggg 1409881 tatcggtcat taccttccac tcgctagaag acagaatttg caaaaccact tttaaagaaa 1409941 agtcgtcgct tccggaactt cctccgggac ttcctgttat accggaagag tttgaaccgg 1410001 agctgaagct catcacacga aaaccgatta cggcatctca agaagagctt gaagagaaca 1410061 accgggctcg ttctgccaag cttcggattg ctgaaaaaag aaaataacga aacgcgaacg 1410121 caaaattaaa aggaggtcat cagcctatga gcaatttagc ttaccaacca gagaaacagc 1410181 agcggcatgc gatcagtcct gagaaaaaag tgattgtcaa gaaaagggct tccattactc 1410241 tcggagaaaa agtgcttctt gtcctctttg ctgcggcggt gctcagcgta tcgcttttga 1410301 tcgtatcgaa ggcgtatgcg gcatatcaaa ccaatattga ggtgcaaaag cttgaggagc 1410361 aaatttcatc cgaaaataag caaattggtg acctcgaaaa aagcgttgct gatttaagca 1410421 aaccgcagcg cattatggac attgcgaaaa agaacggctt gaatttaaaa gataaaaaag 1410481 tgaaaaacat acaggaatga ttcaaatgcc aaaaaagaat aaatttatga atagaggagc 1410541 agcgattcta agtatttgtt tcgctctctt tttctttgtc atcctgggga gaatggcata 1410601 tattcaaata accggaaaag cgaacggcga agtgcttgcg acaaaagcga cagagcagca 1410661 tgaaaagaaa cggaccatcg aagcgagccg cggctcgatt ttagaccgaa aaggaaaagt 1410721 cattgcagag gacacagcga cgtataaact gattgcgatt ctcgataaaa aaatgaccac 1410781 tgatgtcaag catcctcagc atgttgtaaa caaagaaaaa acggcggaag cattgtctaa 1410841 agtgataaac ttggacaagg ccgacatcct tgatatctta aataaagatg caaaacaagt 1410901 cgagtttggc tcagctggcc gggatattac gtattcacaa aagcaaaaaa tcgaaaaaat 1410961 gaaactcccg ggcatttcat ttttacggga tacaaaacgc tactatccaa acggagtatt 1411021 tgcatctaat ctaatcggct atgccgaggt tgatgaagaa acaaatgaaa tttccggcgc 1411081 gatgggatta gaaaaagtgc tggataagta tttgaaggag cgggacggat atgtgacata 1411141 tgaaagcgac aaatccggct gggagctccc gaacagcaaa aataaaatta cagcgccaaa 1411201 aaatggtgac aatgtatatt taaccattga ccagaaaatt caaacctttt tggaagacag 1411261 catgacaaaa gtggcgcaaa agtataatcc gaaaaaaatc atggccgcag tcgttgatcc 1411321 gaaaacgggc aaagtccttg ccatgggaca gcgcccaagc tttgatccga acaagcgcga 1411381 tgtgacaaac tactataatg atttgatttc atatgcgtat gaacccgggt ccacgatgaa 1411441 gatctttaca ctcgctgctg cgatgcagga aaacgtgttt aatgcgaacg aaaaatataa 1411501 atcagggaca tttgaagttg gcggagcacc tgttaaggat cacaataacg gtgtaggctg 1411561 gggtccgaca acatatcatg acggcgtcct aaggtcgtcg aatgtcgctt ttgcgaaact 1411621 ggcgaaagaa aagctgggat atgaccgcct caatcaatat ttgcacaaat tcaattttta 1411681 ccagaaaaca ggtattgatt tgccaggaga agtctccagc aaaatcaact ttaaatatga 1411741 atttgataag gcgtcaactg catatggcca agcgtctgcg gtcacaccaa ttcagcagat 1411801 tcaggccgca acggcaattg caaatgacgg taaaatgatg aaaccttatg tcattgacca 1411861 tatcgttgac cctgataaag ataaaactat ttatcaaaat aagccggaat cagccggaac 1411921 tccaatttct gcaagtactg cgaaaaaggt gcgggatata ttaggagaag tcgttacatc 1411981 gaagatcgga acagggcaag cttataaaat cgaaggtttt gatgttgccg ggaaaacagg 1412041 tactgcgcaa atagccggta aaggcggata tttagacggc acagataact atatcttttc 1412101 gtttatgggt atggcgccaa aagatgatcc tgagctttta atttatgttg ctgtacagca 1412161 gccgcaacta aaagcaggac aaagcagttc agatccagta tcagaaatct tcaatccaac 1412221 aatgaaaaat agcctgcact acctaaacat cgaaccaact gaaaaatctg actcagataa 1412281 ggaagaaaca aaagcgcaga caatgcctga tttaacagat caaacggtag ctgctgctca 1412341 aaagaaagca aaagaggaga atctcacacc aattgtcatc ggcagtgatg tcgctgtaaa 1412401 agaacagtat ccgaaagcgg atgaggaagt tctcaccaat caaaaggtct tcctgaaaac 1412461 gggcggcaaa atcaaaatgc ctgatatgac aggctggtcg agaagagagg ttctgcagta 1412521 cggcgagctc gcgggaattc atattgaagt aagcggacaa ggctacgctg tcagccaaag 1412581 tgttaagaaa gacaaagaaa tcaaagacaa aaccgtaatc aaggttaagt ttaaaaatcc 1412641 tgattaaaaa gaaagccgtc gttatgcagg ctttcttttt ttatgccttc agaggagcat 1412701 cgttctacct gtccaaattc aggcataaaa tgaaacaagc ctaaataagg agtgaacggt 1412761 ctcttgcgcg tctcgaatgt aacggttaga aaacgtttat tatttgtttt gctttttggc 1412821 gtgatcgtgt ttctgatcat tgatacaagg ctggggtatg ttcagtttgt gatgggcgaa 1412881 aaactgactt cgctagcgaa agattcctgg agccggaact tgccgtttga gccggagaga 1412941 ggcgagattc tggatcggaa tggtgtgaag ctcgcaacaa ataaaagtgc gccgaccgta 1413001 ttcgtcgtgc cgcgccaagt tcagaatccg atgaaaacga gcaagcagct tgcggcggtg 1413061 ctcaatatgt cagaagaaaa agtatataaa catgtgacaa aaaaagcgtc aatcgaaaag 1413121 atcactcctg aagggagaaa aatttcaaat gagaaggcga aagaaatcaa agcgcttgat 1413181 ttaaaaggtg tgtatgttgc ggaggacagt atccgtcatt acccgttcgg cagcttttta 1413241 tctcatgtgc ttggatttgc aggaattgac aaccaagggc tccttggact tgaagcctat 1413301 tacgacgatg atttaaaagg ggaaaaaggt tctgttaagt tttatacaga tgccaagggg 1413361 aagaagatgc ctgatgaagc ggatgactat acgccgccta aggatgggct tgatatgaag 1413421 ctgacagttg attcaaaggt tcagacgata atggaaagag agcttgataa cgctgaggcc 1413481 aaatatcatc cggacggcat gattgccgta gccatgaatc cgaaaaacgg agaaattttg 1413541 gggatgtcta gcaggcctga cttcgaccct gctgattacc aatctgttga tccgtccgtc 1413601 tacaatcgaa atctgccagt atggagcacg tatgaaccgg gatctacctt taaaattatt 1413661 acacttgcag cagcccttga agagcaaaaa gtaaatttga aacgggatca attttatgat 1413721 aaagggcatg ctgaagtgga cggagcgaga ctgcggtgct ggaaaagagg cgggcacggg 1413781 ctgcagacgt atctggaagt tgtgcagaac tcctgcaacc cggggtttgt tgaattaggc 1413841 gagcgcttag gaaaggaaaa gcttttcaaa tatatcaaag actttggttt tggacaaaaa 1413901 acggggattg atctccaagg cgagggaaca ggcatcttat tcccgcttga gagagtgggc 1413961 ccggtggagc aagcaactac ggctttcgga cagggagtat ccgtcacgcc gattcagcag 1414021 gttgcagcag tatccgccgc tgtaaacgga ggaacgctct atacacctta tattgcaaag 1414081 gaatggatcg atcctgttac gaagaaaacg gtcaaaaaac aatcaccaat cgcaaagaaa 1414141 caagtcattt ctgaggaaac atccaaacaa atccgctatg ctctagaaag cgtcgtcgca 1414201 gaaggaaccg gccgcaatgc atttgtagaa ggatatcgtg tcggaggaaa aacgggaact 1414261 gcacaaaagg ttaaagatgg aaaatatctt gaaaacaacc atattgtatc atttatcggt 1414321 ttcgcgccag cagatgatcc gagtctagtc gtctacgttg cggtggataa cccgaaaggc 1414381 acgattcagt ttggcggaac ggtggcagcg cctattgtcg gaaatattat gagagacagt 1414441 ctgccggaac ttggtgtgaa gccccggaaa aatcaaatcg agaaaaaata ccaatggaac 1414501 gacacaaaaa caatagaagt tccgaatgtt gtagggatgt ctgtctcaga tcttgagtca 1414561 ctattggtga atctcaatgt ggatgcttcc gggaaaggga gcaaaatcgt taaacaatcg 1414621 ccagctgccg gaacgaaagt aaaagaaggc tcaaagatac gcgtgtattt gactgaagaa 1414681 gatgaaaagg aggcagccga ttgattcggg ctgcctattc ttttattgca gaaaaaatgc 1414741 tgatatcttt caagattagc tggatgtatc cttttattta cgctaaaata tgaactgtat 1414801 gcttaaaatc attaccacat catttgatgt gacttcaatg ataaaaagaa cgaattagaa 1414861 tgttgagagg tttgatacga tgaaacttac aaagctgctt acatacttaa caaccgaacc 1414921 ttctgtaaac gactcacaag accctgaaat aacttcaatt gagatggact ccagggaagt 1414981 aaagaaaggg agtctttttg tatgtgtaaa agggtatacg gtggatggcc acgattttgc 1415041 gcaaaaagca gtagaaaacg gtgcagcggc tattgtggca gaaagagagg tcgatgtgaa 1415101 tgttcctgtt attattgtcc ggcagtcact tcgcgcgctc agcgttttgt ctgatgcgtt 1415161 ttacggacag ccgacgaaga agcttcagct gattgggata acagggacaa acggcaaaac 1415221 atcaacgacc cacatggtcg atgagattct gaaaaaagcg ggaaaacgca caggcttgat 1415281 cggtacaatg tacatgaaaa tcggagacga aacacttcct gttaaaaaca cgactccgga 1415341 aagcgtcacg ctgcagaaaa cgtttaagaa aatgaatgac aagcacgttg acactgcaat 1415401 catggaggtt tcttcccacg ctttgtcttt aggacgcgtc catggctgtg attatgatat 1415461 tgccgtgttt acgaatttaa cacaggacca tctggactat cataaaacga tggatgagta 1415521 ccggcatgca aaaagcttgc tcttttccca acttggcggg gctttcaacc atgaacatcc 1415581 aaagcgtgcc gtcctgaatg ctgacgatga ggcgagcgct tattttgaaa aggtaacagc 1415641 tgcgcatatc tctacatacg gaattaaaaa cgatgctgat gtgatggcga agaacatcag 1415701 tatcactgca cagggcacaa gctttgatct cgtgacaaac aaaggcacga agcacatcac 1415761 gatgtctctc gtcggacaat ttaatgtgta taacgtgctg gccgctgttg cgacatgtat 1415821 tgcagcaggc ataccgtttg aaatcatcac tgaggctgtt gaagaattgc atggtgtaag 1415881 aggccgtttt gaattggtca atcagcagca ggagtttcct gtcattgtag actacgcgca 1415941 cacaccggac agccttgaaa atgtgctgga gacatgcaga gacatgacgg aaggaaagct 1416001 atttgtcgtt gtcggctgcg gaggagacag agataagacg aagcgcccga aaatggctaa 1416061 aattgctgtg gagctggctg acgagccgat tttcacgtca gataacccga gaagcgaaga 1416121 tcctcgcgcg attttaagag atatggaagc cggagtagag aacgcatact atcacagtat 1416181 tgcaaaccgc gagcaggcga tctttttcgc aattgccaat gccaaaaaag gcgacgttgt 1416241 cctcattgcc ggaaaaggac atgaaaccta tcagcagatc ggaaatgaaa ctttcgattt 1416301 tgatgatgct gaagtagcgg cgagagccat tgttgaactc aataagaata agacgaattc 1416361 ataggaaaga gatgttactg aataatggag cttgaaaaga tttttcatat ggaaaaaaat 1416421 catgaatatg ataactacgt atgtcgtttg aaagaaacag gaggagaaaa ggacaatgct 1416481 tgagcaagtc attctgttta caattttaat ggggttttta attagtgttc tgctctctcc 1416541 gattcttatt ccgtttttaa gaagattaaa attcggccag agtattagag aagaaggacc 1416601 gaaatcacat cagaaaaaat cagggacacc gacaatgggc ggggtcatga tcatactttc 1416661 tatcatagtg acaacaattg ttatgacaca gaagttttca gaaataagcc ccgaaatggt 1416721 gctgcttctg tttgttacgc taggctacgg tttgcttggc tttttagatg attacatcaa 1416781 ggttgtcatg aagcgcaatc ttggattgac atcaaagcaa aagctgatcg gacaaattat 1416841 tattgcggtt gtattttacg ccgtgtatca ttactacaat tttgcgacgg atattcgcat 1416901 tcctggaact gacttatcat ttgatcttgg ctgggcttac tttatccttg tgctctttat 1416961 gctagtcggc ggatcaaacg cagttaacct gactgacggc cttgacgggt tattatccgg 1417021 tactgcggcg attgcctttg gcgcctttgc cattctggca tggaatcagt ctcaatatga 1417081 cgtagcgatt ttctcagttg ccgttgtcgg tgcagttctg ggcttccttg tatttaatgc 1417141 tcatccggcc aaagttttta tgggagatac gggatcgctt gcattgggag gagccatcgt 1417201 taccattgcc attttaacga aattagagat cctgctggtt atcatcggcg gtgtattcgt 1417261 tatcgagaca ttatccgtta ttttgcaggt catcagcttt aaaacgacag gtaaacgaat 1417321 ctttaaaatg agtccgcttc atcaccatta tgagcttgtc ggctggtctg aatggagagt 1417381 agtcgtgacg ttttgggctg cgggactttt gcttgccgtt ttaggaattt acatcgaggt 1417441 gtggttataa gtggaaaatg atcaattttt acagaaacag cattttttaa tccttgggct 1417501 tgcgaaaagc ggatatgcgg cggcctccat tcttcatgaa aaaggcattt atgttgcagt 1417561 caatgatcaa aagccttttg aagaaaatga accggcacaa aagctttctg aaaaaggaat 1417621 cgaagttgtt tgcggagagc atccagtttc tctgttcgat cagcatcaaa tcacgattct 1417681 gatcaaaaac ccgggaattc cttatgaaaa tatcatggtt caggaagcag agaaacgagg 1417741 tattccggtt tggacggaaa ttgagctcgc ttactacctg accagcgcca agtttatcgg 1417801 gattaccgga tcgaacggta aaacgaccac gacaacgcta atttacgaaa tgctcaaggc 1417861 tgactcgcaa aaagcactga ttgccggaaa catcggcaca gtcgcaagtg aggttgccta 1417921 tcatgctgat ggagatgaat ggatcgttac cgaactgtct tcgtttcagc tgatgggaac 1417981 acacgctttc agaccggaaa tcagcctgat tttaaatgta tttgacgccc atctggatta 1418041 tcaccatacg cgcgaaaact atgaaaaagc gaaacagaaa gtgtaccttc atcagactgc 1418101 ttcagataaa gctattgtca accaggatga tgaaaccgtc gtgcgtcttg ctgaagccgg 1418161 aaaagccgaa atcgtcccat tttcagtcag caaaacgctt gaacagggcg catatgtaaa 1418221 agacagtatg attatgttta acggcgaagc cattcttcct ctggaagagg ttgtactgcc 1418281 cggtgctcat aacctggaga acattttagc agctattgca gttgtgaaaa cggcaggagc 1418341 atccaatgag gcggttaaaa aggtgctgac aagctttact ggtgtgaagc accgcctcca 1418401 atatgtcaca actgtgaatg gccgcaaatt ttataacgac agtaaagcaa caaacattct 1418461 ggcgacaagc aaggcgcttt cagcttttga taagccggtc attctgcttg cgggcggact 1418521 ggatcgcgga aatggttttg atgacttgaa accttatatg aagcatgtca aagcagtgct 1418581 tacatttggc cagacggcgc caaaactcga gaaactcggc aatgaactgg gaatacaaca 1418641 tgtcaaacgt gtcgataatg ttgaacaagc agtatctgcg gcgtttgcgc tctcaaatga 1418701 aggagatgtc atcctgctgt cacccgcgtg tgcgagctgg gatcaattca aaacatttga 1418761 agaacgcggt gacatgttta tagatgccgt gcatatgctt aagtaagggc ttgtcttgaa 1418821 gtaaatcggc agccctaatg actttaagct tggggtgtcg attgctttga ctactaaaaa 1418881 aacatcgcct gatttgttat tggtcatcat tacgttatta ttattaacaa tcggattaat 1418941 tatggtgtac agtgcgagtg cggtatgggc ggattataaa tttgacgact cattcttttt 1419001 cgcgaaacgg cagcttttgt ttgcgggaat cggcgtcatt gctatgtttt ttatcatgaa 1419061 tgttgattat tggacttgga ggacatggtc caaattgctg atggttatct gctttttcct 1419121 tctggtgctt gttttgatac cgggcgtcgg aatggtgcgg aacggttcaa gaagctggat 1419181 cggagtcgga gcattcagca tacagccttc agagtttatg aagcttgcga tgattgcatt 1419241 ccttgctaaa tttctctctg aaaaacaaaa aaacatcaca tcgttcagac gggggttcgt 1419301 ccctgcactt ggcatcgtgt tttcagcatt tttgattatc atgtgccagc ctgacctcgg 1419361 aacggggaca gttatggtcg gaacttgtat tgtcatgatt tttgtagccg gcgcacggat 1419421 cgcccatttc gtctttctcg ggctgatcgg cctcagcgga tttgtcgggc tcgtactatc 1419481 ggctccatat cggataaagc ggattacctc atacttaaat ccatgggaag acccgctcgg 1419541 aagcggattt cagatcattc aatcgcttta tgcagtgggg cccggcgggt tgttcggaat 1419601 ggggctcgga caaagcagac agaagttctt ttatctgcct gagccgcaaa cagactttat 1419661 tttcgccatc ttgtcagagg agctgggctt tatcggggga acacttattt tgctcctctt 1419721 cagcgtcctg ctgtggagag gaatcagaat tgcgcttggt gcgcctgatc tgtacggaag 1419781 ctttgtcgca gtcggcatta tttcaatgat tgccattcaa gtcatgataa atatcggcgt 1419841 agtcacgggc ctgattcctg taacaggcat cacgctcccg tttctgagct acggaggctc 1419901 ttcattgact ctaatgctga tggcagttgg tgtgctgctg aatgtaagcc gctactcgag 1419961 gtattaacga atgtatttcc aagcctcctg tctaacatga agcttggaaa caattgatgc 1420021 gataaccctg tccaacaaaa cagggttatc gttatgttat agagaaactt agactggggg 1420081 aaaaaagaaa tgcgaattgc aataagcgga ggcggtacag ggggacatat ttatcctgct 1420141 cttgctttta ttaaagaagt gcaaagacgt catcctaatg tggaattttt atatatcgga 1420201 acagaaaacg ggctggagaa aaaaattgtt gagcgggaga atataccgtt tcgttcaatt 1420261 gaaattacag gatttaaaag aaaattgtca tttgaaaatg tcaagactgt gatgcgtttt 1420321 ctgaagggcg tcaaaaagag taaatcgtat ttagcggaat ttaagcccga tgccgtaatt 1420381 ggaacgggcg gttatgtatg tgggccggtt gtctatgccg ctgcgaaaat gggaattccg 1420441 actattgtcc acgaacaaaa cagcctgccg ggcatcacga ataagtttct ttcaaaatat 1420501 gttaataaag tagcgatttg ttttgaagaa gcgaaatcac attttcctag cgagaaagtt 1420561 gtatttacgg gaaacccgag agcctctgaa gtcgtctcaa taaagacggg acgatcattg 1420621 gctgaatttg ggctttctga agacaaaaaa acggtcttaa ttttcggcgg aagccgaggc 1420681 gctgcaccga ttaaccgcgc tgtcattgac atgcaggatg tgctgaaaac aagagactat 1420741 caagtgctgt atatcaccgg tgaagttcac tatgaaaaag taatgaatga gctgaaaagc 1420801 aagggtgccg ctgataatat ggtcacaaag ccgtttcttc atcaaatgcc tgagtattta 1420861 aaggccattg atgtcattgt ggccagagcc ggtgcgacaa cgattgccga aattactgct 1420921 ctcggaatcc caagtgttct gatcccaagt ccatatgtga cagcgaatca ccaggaggtc 1420981 aatgcgaggt ctcttggcca gcatgatgcg gcgattgtac tgaaagaaac agagctcagc 1421041 ggggagaagc tgattgaagc gctagaccgg attgtactga atgagcaaac gttaaaggaa 1421101 atgagcgaac gaacaaagtc actcggtgtt cctgacgcgg ctgcccgttt atacagcgta 1421161 ctcgaggaat taaaaaaata gtagaaaagc aaatggaatg cggaggttta cgatggagaa 1421221 agtgatacag gaattaaaag aacgagaagt cggcaaggtt cttgcaaatg aaccgctcgc 1421281 gaatcataca acgatgaaaa tcggcggacc tgcggatgta ttggtcattc caagcagtgt 1421341 ggatgctgtt aaagacatca tggacgtgat taaaaaatat gatgtgaagt ggacagtcat 1421401 cggccgcgga tcaaatcttc ttgttttaga tgaaggaatt agaggcgtag tgatcaagct 1421461 gggggcgggt cttgaccatt tggagcttga aggggaacaa gtaacagtcg gaggcggtta 1421521 ttcggtggtc cgccttgcta catcattgag caaaaaaggc ctgtccggtt tggaatttgc 1421581 tgccggcatt ccaggatcag tcggcggagc ggtttatatg aatgccggcg ctcacggttc 1421641 tgatatgagc gagatcctcg tcaaagcgca tattttattt gaagacggaa cgattgagtg 1421701 gctgacaaat gagcagatgg atttcagcta caggacatct gtactgcaaa agaaacgccc 1421761 gggcgtttgc cttgaagctg ttttgcagct tgagcagaag gataaggaat caatcgttca 1421821 gcaaatgcaa agcaataaag actatagaaa aaatacacag ccgtattcaa gcccttgtgc 1421881 gggaagcata ttcagaaatc cgcttccgaa tcatgccggg aaccttgtag aaaaagcagg 1421941 cttgaaagga tatcaaatcg gcggtgcaaa gatatcggag atgcacggaa acttcatcgt 1422001 caatgcgggg ggagcatcag caaaagatgt gcttgatctc attgaccatg tgaaaaagac 1422061 aatccgtgaa aaatacgaga ttgatatgca cacagaggtt gaaatcatcg gcggaaatcg 1422121 ctgattcaag ttctgactga agctgttcat atgatatact gtaagcaaac gacaaacggc 1422181 atcatagtat gccgtttgtt ttggaataga cagactttta acagctgttt catttgaatg 1422241 aggtgaacag gcaatgaacc cgggtcaaga ccgagaaaaa atcgttaaca ttgaagagcg 1422301 gatccctaaa attaaagagc agaggaaaca aaaggcaaac cgccgtctca tttcatttat 1422361 tatgctcttt tttattatgg tgctgatcat tgtgtacctg caaacaccaa tcagtaaagt 1422421 atcaacaatc tctgttacag ggaatgaaaa tgtatcaaaa aaggaaatta tcgacctttc 1422481 cgatattaac agcggagata ctgagttttg gagtttggac aagcaaaaaa cagaaaagaa 1422541 gattcagcaa aataaattag tgaaaaaagc ggagatcagc aaatcgcttc ctaataaaat 1422601 caacattgca atcgaagaat ataaagcgat tgcttattta gaaaaagacg atgtgtacta 1422661 tgaagtgctt gaaaacggct cagttctgcc aaacgaagta acgccggatg atgccggacc 1422721 gattttagtg aattggacaa acgcgaagaa gcggtctcaa atggccaagc agctcgatgc 1422781 gttgtcaaat tcgttaaaac agtcgatttc agaaatttat tatacgcctg taaaaatgga 1422841 tgaaaaccgt attaagttgt acatgaacga cggttatgtt gttacggcat ctattaaaac 1422901 gtttgcagac cgaatgaaga cgtatccttc tatcatctca cagctaagca gcaataaaaa 1422961 aggaatcatt catttagaag ttgccaccta ttttgaagag tttgggaaaa acgataaagc 1423021 tgctaaaaag gaagatgaaa attgaggggc aaatcagcag tccttctttc cttgattatg 1423081 cttatcgcag gttttttgat ttcattttct tttcaaatga caaaagaaaa caacaaaagc 1423141 gcggctgaga cggaagagtg gaaaaaagaa tatgcgctga gagatgaact gctgaaacaa 1423201 gagaaagaaa ataagaagtt tgaaaaagaa ttatatcaaa agcaaaacaa agtccgccag 1423261 gcggaaaata agctgaagaa agagaagtcg gaatactata atgtcctcga agatacagaa 1423321 aaatacagga tgtatattgg ggaagtcggt gtgcagggag aaggcgttga ggtgacattg 1423381 gaagatgcgt catacatacc ggaaggggag aatgtgaata gttacatcgt tcacgaaagc 1423441 catatcttcc aagtagtaaa cgaactgtat atctcaggag cggcagctgt cgccgttaat 1423501 ggacagcgtt tgacgcatga ttcgtatatc aaatgcaatg gtcctgtggt aacggtagac 1423561 ggggtgcagc atcccgctcc gtttacggta tccgctattg gagatccaga tgtcctgctg 1423621 ccctcgttaa atatcgctgg aggcctaatt gatcagctgt caatggatca tatttctgtg 1423681 tcggcagaaa aagagaaaaa cgtacaaatg aaaccgattc tgaaaacgaa ggaatgactg 1423741 aaaaagcggg tgaaatagat tgaaaataaa gcgttccttc ataagcatca gtgttcttat 1423801 ggtcatcttc ggcctgatga tatctgttca gtttaattcg ttaaagcacc ccaaagtccg 1423861 ggatacaaga gatatgtggg atattaggga agagctgaca tcagagcaga agaagcagga 1423921 aaagctgctg gctgaaataa acaaatatga caaattgctg aatagctatt cgcaaacgaa 1423981 agaaatgaca aaagaaaccg cgctaaataa taccttgcaa tccttaaaaa aaacagccgg 1424041 catgaccgat ataacaggta gcggaattgt cattacgatt tccccgcttt tttctgaaag 1424101 cttaacagga gagccgatcg aaaatccgcc tccggatttg ctgaaaaagc tgataaatga 1424161 actcaactcc tacggtgcag agcatatctc gattaatgag cgaagagttg tgaatcatac 1424221 agtcatcaga gatataaacg gcactacaaa aatagacgga tacgcccttg acgattatcc 1424281 tttaacagta aaagtgcttg ccaaagatcc ggacatgtta cacagcagag tgaaggggtc 1424341 aggccttgag gatctttttg catctgaaaa tttagcatta aaagccggta aatctgaaag 1424401 caaactaaca ttaaaagcat atgacagacc actggacgta caacagctga aactgcttaa 1424461 agactgaaaa ggaggagaat tgtcatgtgg ctgcccgtgt tgggactggt gctcggaata 1424521 gcgattggac taatgacaaa cttaacgata ccgagtgaat actcaaacta tttatcgctt 1424581 gcggtgcttg ccgcacttga tacattaatc ggcggaatca gggcgcattt acaaggtaca 1424641 tatgatgaaa tggtatttgt ttccggtttc ttttttaata ttatattggc aataagttta 1424701 gcttttctgg gagtccatct tggtgtagac ttgtatttag caggtatatt cgcatttgga 1424761 gtcagattat ttcagaatat agccgttatc agaagaaatc tactaacaaa gtggactctt 1424821 tctaaaaaaa ataaaaaaaa tgtgatataa aagaggatat acataggata taacgaatat 1424881 tttcaataaa cataaaatgt gaaaagcaca taaaaatatt ctgttgttat tttttgttac 1424941 acacttgtaa agccacattc attgtattgt tgttccgcaa ataatagaat agaaatgatc 1425001 gaaatgtgag gaggtgccat agaatgaaca acaatgaact ttacgtcagt cttgacatcg 1425061 gtacgtccaa tacaaaagtg atcgtcggag aaatgacaga tgattccctt aatattatcg 1425121 gtgtgggaaa tgtaccgtct gaagggttga aaaaaggctc aatcgttgat atagatgaga 1425181 ccgttcattc tataagaaaa gcgtttgacc aagctgaaag aatggtaggt tttccgctta 1425241 gaaaagctat tgtcggcgtt aatggaaatt atatcaatat tcaagataca aacggtgttg 1425301 tagcagtttc cagtgaaaat aaagaaattc aggttgaaga tgtacgccgt gtcatggagg 1425361 cggcacaggt tgtttccgta ccgcatgaac agctgattgt tgacgtcatt cctaaacagt 1425421 ttatcgtaga tggaagagat gaaatcaccg acccgaaaaa aatgctgggt gtgcgtttag 1425481 aagtagaggg caccttgatc accggttcaa aaacaatctt acataactta ctccgctgcg 1425541 ttgaaagagc tggtattgaa ataactgata tttgccttca gccgctggca gccggttctg 1425601 ctgcattatc aaaggacgag aaaaaccttg gtgtggctct cattgatata gggggagggt 1425661 caacaaccat tgccgtattc cagaacggac atctcacttc tacccgtgtc attcctctcg 1425721 gaggcgaaaa tatcaccaaa gatatctcca tcggattgag aacgtcaaca gaagaagcag 1425781 aacgcgtgaa aaagcaactt ggacatgcct actatgacga agcctcggaa gatgaaatat 1425841 ttgaggtaac cgttataggc accaatcaaa aacaaacatt tacacagcaa gaagcagcga 1425901 atatcattga agcgagagta gaggaaattc ttgaaattgt ttcagaagag cttcgcagta 1425961 tgggaattac cgatctgccg ggaggcttcg tgctgacagg aggacaagca gctatgccgg 1426021 gtgtcatgtc tttggcacag gatgtgctgc aaaacaatgt cagagtggca agcccgaatt 1426081 atatcggtgt aagagatcct caatatatga cgggagtggg cctgatccaa ttcgcctgcc 1426141 ggaatgcaag aatccaaggc agaaaaatag gctttaagat gcctgaagaa gcgatacagg 1426201 aaatcgcagt ctcatcatct gaggaacaag agcagcatca tcaccaaaat gaggtgcagc 1426261 agcggccaaa aggaaaacaa aaaacacaag ccgaacataa taaacagagc aaaatgaaaa 1426321 aactattaag catgttttgg gaatagatag atagtcattc ggcagattag gaggatttag 1426381 catgttggag ttcgaaacaa acatagacgg cttagcatca attaaagtaa tcggagtagg 1426441 aggcggcggt aacaacgccg ttaaccgaat gattgaaaat gaagtgcaag gagtagagta 1426501 tatcgcggta aacacggacg ctcaagctct taacctgtca aaagcagaag tgaaaatgca 1426561 aatcggcgca aagctgacta gaggattggg agcaggtgcg aatccggaag tcgggaaaaa 1426621 agccgctgaa gaaagcaaag agcagattga agaagcactt aaaggtgctg acatggtatt 1426681 cgtgacagct ggtatgggcg gcggaacagg aacaggtgcc gcaccggtta tcgcacaaat 1426741 cgcgaaagac ttaggcgcat taacagtcgg cgttgtgaca agaccgttta ccttcgaagg 1426801 acgcaaaaga cagcttcagg ctgcaggcgg aatctcggca atgaaagaag cggtggatac 1426861 actgatcgtg atcccgaacg accgtatcct tgaaattgtt gataaaaaca caccgatgct 1426921 tgaagcattc cgcgaagcgg ataacgtact tcgccaaggg gttcaaggta tttctgactt 1426981 gattgctaca cctggtctta tcaaccttga ctttgctgat gtgaaaacaa tcatgtcaaa 1427041 caaaggatct gctttgatgg gtatcggtat tgctactggg gaaaatcgcg cggcagaggc 1427101 agcaaaaaaa gcaatttcca gcccgcttct tgaagcggcc attgacggtg cgcaaggcgt 1427161 cctcatgaac atcactggag gaacaaacct cagcctatat gaggttcagg aagcagcaga 1427221 cattgtcgct tcggcgtctg atcaagacgt aaacatgatt ttcggttctg ttattaatga 1427281 aaatctaaaa gatgagattg tggtgacagt gattgcaacc ggctttatcg aacaagagaa 1427341 ggacgtgacg aagcctcagc gtccaagctt aaatcaaagc atcaaaacac acaatcaaag 1427401 tgttccgaag cgtgagccaa aacgtgagga acctcagcag cagaacacag taagccgtca 1427461 tacttcacag ccggctgatg atacgcttga catcccgaca ttcttaagaa accgtaataa 1427521 acgcggctaa tgtaaaggac aaaatcgttt tcgattttgt ccttttttgt ttttctcttc 1427581 acactttcct tcttataaag tctttttccc tattgcttcc ttcgcgagct cgattatgga 1427641 tggtttacgt tttggaaaaa gtaaggtatc ctagttcgta caaagtttta tgaaaattaa 1427701 aacaattata aaaggcaata aagaggagga ccacgatgat tttgcagctt gacaatgtct 1427761 cactaaaacg gaatgggaaa tggatactga aagatattca ttggaaggtg gaagaaaagg 1427821 aaaattgggt gctttacggc ctaaatggcg ccgggaagac agcgctgtta aatatgcttt 1427881 gctcatatta ttttccaaca tcaggcgaga tgcaggtgct cggccatgaa tttggcaaaa 1427941 cagagcttgg ggaaaagctc agacgtaaaa ttggcctcgt ctcagcagct cttcagcaaa 1428001 aattgtatcc ggcagattca gcttttgaaa ttgctttgag cggagcttac gcttcgattg 1428061 ggttatatga aacgccaagt aaggaaacca gggaaaaagc gataggtttg ttagaggact 1428121 tgggagcaat tgaatatgcc gatcgccgct atgaaaccct ttctcaaggg gaaaaacaaa 1428181 gagcattgat tgctagagca ctaatggccg atccggagct gctgatactg gatgaaccag 1428241 tcacaggact ggattttatt gcccgggaaa agctgttaga tacgattaca tacattgcaa 1428301 acaaagaaaa tgcaccatct atcctttatg tgactcatca tgctgaagaa attttgcctg 1428361 tctttgataa agccctttta ttaaaacagg gagaggtttt tggatccgga gaaataaagg 1428421 aaatgcttac tgatcaaata ctttccgctt tttttgatac gccaatccat gtattatgga 1428481 atcaggatcg gccgttttta acaagagctg agccgataac gaatgcctga caaatatata 1428541 tagattcatc ctaggggtgc tttgcgaagc tgagagagac tttgtctcaa cccttttgac 1428601 ctgatctgga tcatgccagc ggagggaagc ggtgaaaagc ggagtacatc ggactccgtt 1428661 tgtttttatt aagccgtttc atcacatttg aaacggcttt tttgatttta aagaatagga 1428721 gcggatttac attggatcaa caaatatact ctttgcaaaa aaaagtggaa gaacataagg 1428781 aggagcttat tcagcttgcg aaaacgctga tttcttatca aacacctgct ccgcctgcaa 1428841 gaaatacaga gggcattcag tcttggattg cgggatattt aaatgaattg ggattctcga 1428901 tcgacaaatg ggatgtgtac cctggagatc ccaatgttgt agggaagcta aaaggaacag 1428961 attcagcaga ttattatagc ctgattatca atggccatgt agatgtggca gaggtaaaag 1429021 aggatgaaga atggaagcac gatccgtttc atcccattga aaaaaacggt ctcttaatcg 1429081 ggcgaggcgc ttccgatatg aagggcggaa tggcttgtgt gctgtttgct gtcaaattaa 1429141 ttcgtgaagc aagcattgaa cttccaggtg atctgattct gcaatcggtt attggggagg 1429201 aagttggaga ggccggcaca cttgaatgct gcaagagggg ctaccacgct gattttgcaa 1429261 ttgtcgcgga tacgagcgat atgcatattc aaggccaagg cggtgtcatt acaggctgga 1429321 tcgaaatcaa aagcagtcaa acatttcatg atggaacgag acggaatatg attcatgcag 1429381 gcggaggaac attcggagca agcgcaattg aaaaaatggc aaaaatcatt gcggggctcg 1429441 gtgaacttga gcgccactgg tctattatga aaagttatcc cggttttaaa ccaggcacaa 1429501 atacgattaa cccggcagtt atagaaggcg gcagacatgc ggcttttata gcggacgaat 1429561 gccggctgtg gatcacagtc catttttatc cgaatgaaac ccatgaccaa gtggcagcgg 1429621 aaatagaaga ttacgtcaat cggctgagtg acagtgatat ttggcttagg gaaaaccgcc 1429681 ctgtattcaa gtggggaggc tcatctatga tagaagacag gggagaaatt tttccggcat 1429741 tggaagttga ccctggccac ccaggcgtct tagcgctaac tgcctctcat cagaaagtga 1429801 aacgggagtg tccaattatt gacgtttctc aatcagttac agatggcgga tggctgtatg 1429861 atgccggtat tccatgcgta atatacggtc ctggagatct gcacaatgca cactctgtga 1429921 acgagaaggt atcgattgag cagctagtag agtatacaaa aattatactc gattttatca 1429981 tcagctggtg cagccggaaa aaagaacaat gacatgaaaa tttcttcttg ctgacaaggt 1430041 tcagcctgcc cgttcatata cttgaacaaa aggacggaaa aaggacgtga tggaatgatc 1430101 agcatttcag aatttcaggt aaaggatgtc gtcaatgtct caaacggaaa aaagctgggg 1430161 agtattggtg atattgatat caatgtgacc actggaaaaa ttcaggcgat catactcgga 1430221 ggaaatggga aagttctcgg attttttgga aaagaagagg aattggtcat tccatggcga 1430281 aatatagtaa aaatcgggga agatgtaatc ttagtccgat taagtgaacc acatgcataa 1430341 acctgcttgt ctgccgcaga ttggcaaatg ccggaagtct cgattcttcc ggcacatttc 1430401 atttagaaat atgcaaatcg gcgctcaacg aatgcagtaa gatgtggtaa aataagtggg 1430461 aaattccgct tttttaaatg tttgtcgaaa ggttggatca tcatgaatac atatcaccca 1430521 ttcagtctta ccacaccctc gacactcatg atacaagact gggctcaaac gaatcaaaac 1430581 aacaaagagg tcattgccgg atttacgaca aaaaacggcg gtgtcagcca aaagcctttt 1430641 gaatcgttaa atacaggatt gcacgttcat gacaaagatg cagatgtagt taaaaatcgt 1430701 gaatatattg ccgatatgtt taatactgat ttgcagtctt gggtattcgc tgatcagaca 1430761 catgataatc gcgttcagaa agtgacgcag agggataggg gaaaaggcgc ccgtgagtat 1430821 cacacggctc taaaagcaac ggacgggatc tatacaaatg aaaaaaatgt atttttagca 1430881 ttatgctttg ctgattgtgt gcctcttttc ttttatgatc cggttaagtc gcttgtcgga 1430941 gtcgcccatg ccgggtggaa aggcaccgtc aaacagattg gcagagaaat ggtgaagcaa 1431001 tggactgaga aggaaggttc aaatccctca gatatttacg ctgttattgg cccgtctatc 1431061 agcggagcat gctatacggt agacgaccgc gtcatggatg ctgtccgcgc attgccggtt 1431121 tcagcagacc ttgccgccaa tcagacggca aaggcacaat atcagcttga tctgaaagag 1431181 ctgaaccgtc ttatactgat ggacagcggt ttggcaagtg aacaaatttc tgtcagcggt 1431241 ttatgcacgg aaagcgagcc gtctcttttc tattctcatc gccgcgatca ggggaaaact 1431301 ggacggatga tgtcctttat cggaatgaag gaggcataaa agatcttgcg tgttgttgat 1431361 aatttacgac atataaacga acgaataaac gaagcatgta acagatcggg ccgcagctcc 1431421 gatgaagtta cggttattgc agtcacaaaa tatgtatcac ctgaaagagc acaggaggca 1431481 gtagatgctg gcatcacctg cctcggagag aatcgggatg cggaactgct ccgcaaacag 1431541 gaattgatga aagggaatcc ggaatggcat tttatcggca gtctgcaatc aagaaaagca 1431601 aaatctgtcg tcaattcggt ttcctatatc cattccctag accggctctc attagcgaaa 1431661 gaaattgaaa aacgggctga aggtactgta cgatgctttg tgcaggtcaa tacctctctt 1431721 gagccttcta aacatggcat gaaaaaagaa gaagtcattc cattcataca ggagctttcc 1431781 ggtttcgaac atatccttgt tgccgggctg atgacaatgg ctccgctgac tgatgatcaa 1431841 gatcagatca gaagctgttt caggtcgctg agagaactcc gtgaccaggt tcagaagctg 1431901 aaccagccga acgctccgtg tactgaactg tcgatgggca tgtcaaatga ttttgaaatt 1431961 gcaattgaag aaggagctac ttatattaga atcggctcat cgttagtcgg aaatgaaaca 1432021 gggggtgtac agcaatgagt atgaaaaata aactgaaaaa ctttttctca atggaagatg 1432081 aagaatacga atatgaatat attgagacag agcgggaatc tcatgaggag catgagcaaa 1432141 aagaaaagcc ggcttacaac gggaataaac ctgcgggcaa acagaatgta gtgagcttgc 1432201 aaagtgttca gaaatcctct aaagtggtgt tgagtgagcc gcgcgtttat gcggaggcgc 1432261 aggaaatagc cgaccatttg aagaaccggc gggcagttgt cgtcaatctt cagcggatac 1432321 agcatgacca ggcgaagcgg attgttgact ttttaagcgg aaccgtttat gccattggcg 1432381 gcgatattca aagaatcggc tcagatattt tcctctgcac gcctgacaac gtagatgtat 1432441 caggcacaat ttctgagctc atatctgaag acgaacatca gaggtggtaa agcgagatga 1432501 tcctttatca agttttttcg gttttaagct tattaatcac aatatactca tttgccctga 1432561 tcatatatat ttttatgtca tgggtgccga gtacgaggga aacagcagtc gggcgttttt 1432621 tggcttcgat ttgtgaacca tatctcgaac cattcagaaa aatcatccct ccgattgcaa 1432681 tgctggatat ttcaccaatc gtagcaatac ttgtgcttcg gtttgcgaca accggcttgt 1432741 ggggacttta tcgcatgatt gcgttttaat gtgacagttt gataggggct tggcagcagc 1432801 caagcctctt tacatagaag ggaaagacga tgagcgatat atatcagcac ttcagaaaag 1432861 acgagcgggc ctttattgat caagcgctcg aatggaaaag aattgtccag gagcagtacc 1432921 ggatgaagct gaccgacttt ttagatcccc gagagcaggt catcctctct gctgttacgg 1432981 gacaggcaga tgtcgggctt gccttttccg gcggctatga cagagcggag cggaaacggg 1433041 cgattctgtt tccagagtac attactccgg aagaatcaga ttttgaactg caggcgttta 1433101 acgtccgtta tgctgacaag tttgtctcag tagatcatcg ttctctgctt ggtgcattaa 1433161 tgggcatagg attaaagcgg caaaaattcg gtgacatcgt gttttctgag acagcagtgc 1433221 aattgattgt ctcagccgat accgctgatt ttgtggctgc acagctgacc caagcaggca 1433281 aagcggcggt cagcctagag aaaatcgact tgtcagacct taacattcca gcagttgatg 1433341 tcgaaataag agatgacacg gtttcttctt taaggcttga cgccgtctgc gcctctatga 1433401 gcaggcaatc ccgccagaaa tcacagacgc ttgtgaaaaa cggccttgtg aaagtgaact 1433461 ggaaggtggt tgaagatcct tcatacatag tcgcggaagg ggacatgctg tctatcagag 1433521 gttttggccg gtgcagctta acaaaaatcg aaggaaaaac caaaaaagac aaatggagag 1433581 ttacgtttga acgacaaaaa tagtcggttt ttcagttttt ttctccatct gtgcgaaatt 1433641 tgttttataa tgtgaactag ataaccgtac tgaaatgtaa aaatggaggt ggcatcatgc 1433701 cattaacgcc aaatgatatt cacaacaaga cgtttacaaa aagttttcgc ggatatgatg 1433761 aagatgaagt aaatgaattc ctagcccaag tcagaaaaga ttacgaaatt gttctccgca 1433821 agaaaactga gcttgaagcg aaagtcaatg agcttgatga aagaatcgga cactttgcca 1433881 atattgagga gacattgaat aaatcaattt tagttgctca agaagcggct gaagacgtaa 1433941 aacgcaattc tcaaaaagaa gcaaagctga tcgttcggga agcggagaaa aacgctgatc 1434001 gcattatcaa cgaatcgtta tcaaaatcaa gaaaaattgc aatggaaatt gaagagctga 1434061 aaaaacagtc taaagtgttc agaacacgtt tccaaatgct gattgaagct cagcttgatc 1434121 ttctgaaaaa tgacgattgg gatcatctcc ttgagtatga agtcgacgct gtatttgagg 1434181 aaaaggaata aattctctga ttatcttgac attttcttag cttgtcgaat ataatacgtt 1434241 cataaattca gatgaaaaaa cggttgaaag ggacagtcat gtttccttca ggccttcata 1434301 gcgacccgga gatggtgaga gtccgggatg gccggaatca tgtagatcag ccctttagtt 1434361 tccttgctga actcacagta ggttaggacg ttcatcacgt tacgatgctc aagaggaaaa 1434421 agtgtatgct tgctttttct aaaagggtgg taccgcgaga taagctttct cgtcccttat 1434481 gggatgagag ggcttttttt attttctgaa aaaatgcagt ggaggaatga aaatggattt 1434541 taaagacacg ctcttaatgc cgaaaacaga tttcccgatg cgtggaaatt tgccaaaccg 1434601 tgagcctgac attcaaaaaa aatgggagga agaagatatc taccgtcttg ttcaggaacg 1434661 gacgaaagac cgcccgaaat ttgttttaca tgacggacct ccgtatgcaa acggcgacat 1434721 ccatatgggc catgcactta acaagatttt gaaagacttc attgtccgct ataaatcaat 1434781 gagcggctac aacgcaccgt atgtgccggg ctgggataca cacggattgc caattgaaac 1434841 agctctgaca aaaaacaaaa aggtcaaccg caaagaaatg tcagtagcgg aattccgcaa 1434901 actatgcgaa gagtacgctt ggaagcaaat cgagggacag cgtgagcaat tcaaacgtct 1434961 tggtgtccgc ggtgactggg aaaacccata tgtgacatta aaaccggaat acgaagcgca 1435021 gcaaatccgc gtatttggtg aaatggcaaa acgaggctac atttacaaag gccttaaacc 1435081 ggttaactgg tcaccttcaa gtgagtctgc tctggctgaa gccgagatcg aatatcaaga 1435141 taaacgttca gcatctattt acgtcgcttt tggtgtaaaa gacggaaaag gcgttcttga 1435201 aaacggcgag cgcatcatca tttggacaac aacgccgtgg acaattccgg cgaacctcgg 1435261 aatctcagtg caccctgatc ttgagtacag cgtgattgca gtaggtgaag accgctttgt 1435321 tgtagcaagt gccttagtcg aaaatgttgc atcggcatgc ggatttgatc agtatgaagt 1435381 gacaagaacg gtcaaaggga aagaccttga gaacattatc gctgaacacc cgctatatgg 1435441 cagagactct ctcgttatgc ttggtgaaca cgtaacaact gatgccggaa caggctgtgt 1435501 tcatacagcg cctggacatg gggaagatga ctttatcatc ggccaaaaat acggtttaga 1435561 tgtgctttgc ccggtcgatg aaaaaggtgt aatgacaagc gaagctcctg gctttgaagg 1435621 catgttctat gatgatgcaa acaaagcgat cacacagcag cttgatgaaa aaggcgcact 1435681 tgtgaagctt gaattcatta ctcattctta tccgcatgat tggagaacaa aaaaaccaac 1435741 cattttcaga gcaacagcgc aatggtttgc gtctattaaa gatttcagat cagacctgct 1435801 ggatgccatt aaagaaacca aatgggttcc tgaatggggc gagcagcgtt tgcacaacat 1435861 ggttcgggac cgcggagact ggtgtatttc cagacagcgt gcgtggggtg tgccgattcc 1435921 ggtattttac gctgaaaacg gagaaccggt tattacagat gaaaccattg aacatgtttc 1435981 tgaattgttc agacagcatg gatcaaacat ttggtttgaa aaagaagcaa aggatcttct 1436041 tccggaaggc tttacgcatc ctggcagccc gaacggcaca tttacaaaag aacaggatat 1436101 catggatgtt tggtttgatt caggctcttc acatcaagca gtgcttgaag aacgtgatga 1436161 cctcgttcgc ccggctgatc tatacctaga gggatctgac caatatcgcg gctggtttaa 1436221 ctcttctctt tctacagcag tagccgtaac agggaaagcg ccgtataaag gtgtgctcag 1436281 ccatgggttc gcactggatg gagaaggacg taagatgagt aaatcaatcg gtaacgttgt 1436341 tgttccggct aaagtcatga aacagcttgg tgccgacatc ttaagattat gggtatcttc 1436401 agtggattat caggcggacg ttcgcgtgtc tgacgccatt ctgaagcagg ttgcggaagt 1436461 atatcgtaaa atccgcaaca cgttccgttt ccttcacggc aaccttttcg attttgatcc 1436521 aaaaacaaat gcggtggctg tcgaagatct tcgcgaagtg gatcagtata tgctgattaa 1436581 gctgaacaag ctgattgata aagtgaaaaa agcgtatgat gagtacgaat ttgcggttgt 1436641 gtatcacagc attcataatt tctgcacaat cgaattgagc tcattctacc ttgattttgc 1436701 aaaagatatt gtctacatcg agcatgcgga tcatccggat agacgcagca tgcagacagt 1436761 attctacgaa acgcttcttg cattagtgaa gctttcagcg cctatccttc cacatacggc 1436821 agacgaattg tggtctcatt taacatttgt tgaagagcag agcgttcagt tgaccgatat 1436881 gccggaaaca atcacggttc caaacagtga agcgactgaa gaaaaatttg accgctttat 1436941 ggctcttcgt gatgacgtgt taaaagcatt agaaactgcg cgaaatgaaa aaattatcgg 1437001 taaatctttg gaagcaaacc tgaaattgta tccaaacaaa gaaaacaagg agctcttggc 1437061 ttccataaaa gaaaaccttt ctcagctgtt tattgtgtct gaactgacaa tcagcgaaga 1437121 aaatgaagcg ccgaacgatg cgcaaagctt tgcgacgggt aaaatcgctg tcgagaaagc 1437181 ggaaggcgaa atgtgtgaga gatctcgtgt gatttcaaaa gatgtagggg caaatccgaa 1437241 atatcctaca ctttcattac gcaacgctga aatcgttgaa aaatactatc aaaaataatg 1437301 caaaagagcc cggcgtaaaa gccgggcttt ttttgtgcca agagtgacat cctttagaac 1437361 gaaaggaaaa atcttatggg ctttagatca tcattcacag gcaacaataa agatactacg 1437421 ttaagagcag gagttgtgaa gaatgaatga tcaactgacc gcaatttata cggaacttct 1437481 tctgatgaaa gaagaattac agtcgagatt atttgagtat tcttgctttc aggtttctac 1437541 aagcccgcaa gcagcaatca atcaaaaaca aaaagcaact ctgatctatc atattaaaga 1437601 agaacttcaa gacgttctcc ttgcattgtc caaaatcgaa aacggcacat tcggatactg 1437661 tgaagaaact ggggccccca ttcctcttgc aaagctggca gtgctgccga cggcccgaac 1437721 agcaaacgat tttctttatt ctgtccaatt tgagaaaaaa acgcttccga tatggaaatc 1437781 aacggatatc gaatatggtc aggcactgta tgaataacag tgtctgtccg gttaatatgc 1437841 ctgatatttc tttactccag tgctttttat tgataaaatg cataatggat taaagtaacc 1437901 gtaaactgga ggaacgtttg tgctgtatta tatgattgca ctacttatta ttgcagccga 1437961 tcaattgaca aaatggctag ttgttaagaa catggaactt ggccaaagca ttccgatcat 1438021 tgatcaggta ttctatatca cctcccatcg caatacgggt gctgcatggg ggatattagc 1438081 gggtcaaatg tggtttttct acctcataac aaccgctgtt attattggta ttgtttatta 1438141 catacagcgt tatacaaagg gacaaaggct tcttggcgtt gccctcggac ttatgcttgg 1438201 cggtgccatc ggcaacttta tcgatcgggc tgtcagacag gaagttgtgg attttatcca 1438261 tgttattatt gtcaattaca attacccgat atttaacatc gcggactctt cactatgtgt 1438321 cggcgtaatg cttttattta tacaaatgct gttggacagc gggaaaaaga aaaaggagca 1438381 atagcatgaa tcaaattgat ataaccgctt cagaagaaca aaaaagtgag cggattgata 1438441 aatttttggc atcgactgag aatgattggt caagaaccca ggttcagcaa tgggtaaaag 1438501 acggacaggt tgtcgtgaac ggaagcgcgg tgaaagcgaa ttataaaatt cagccgggtg 1438561 atcaggtgac cgtcactgta cctgaaccgg aagcgctcga cgtcctggca gagcctatgg 1438621 atctggatat ttattatgag gaccaggatg tgctggtcgt caacaaacct cgcggaatgg 1438681 ttgttcaccc agcacccggg catcttacgg gcacacttgt aaacggtctt atggctcatt 1438741 gcacagacct ttccggaata aatggtgtga tgcgcccggg tattgttcac agaatcgata 1438801 aggacacgtc cggtttatta atggtggcga aaaatgatat ggcgcacgag tcactcgtaa 1438861 accaattggt caacaaaacg gtcacgcgga aatatacggc ggttgtccac gggcttattt 1438921 ctcatgatga cggcacaatt gacgcgccga tcggacggga taaaaaagac cgtcaaagca 1438981 tgactgtgac acgtgatggc aaaaacgctg tcactcattt tcatgtgctt gagcgttttc 1439041 aggattttac gttagtggag tgccagcttg aaacagggag aacccatcaa attcgtgttc 1439101 atatgaaata tatcggattc ccattagcag gcgatccgaa atacggccca agaaaaacaa 1439161 tcgactttaa tggccaagcg cttcacgcgg gagttttagg ttttgaccat ccacgaacag 1439221 gagaatatgt cgaatttgaa gcgccgcttc ccgaggatat ggcagaatta atcgaaaacc 1439281 tcagaaaaaa cggttgacag agggtttctt ttctgaaata ataaacgaag ctgaatagat 1439341 tctttaaaac agtccagaga ggctgagaag gataacggat agacgggatg cgtgtatagg 1439401 cgcgcacctt gtcctaaaac ccctctatgc tctggcagga ggggtttttt cttctatatg 1439461 aactgtgagg tgtcacacat tgaatcaaaa agctgtcatt ctcgacgaac aggcaattag 1439521 acgggcgctg accaggattg ctcacgaaat gatcgaacgc aataaaggaa tgaataactg 1439581 cattcttgtc ggcattaaga caagagggat ttacctggca aaacgccttg cggaacgcat 1439641 tgaacagatt gagggaaatc ctgttacagt cggtgaaatt gatattactc tttacagaga 1439701 tgatctttct aaaaaaacaa gcaacgatga accgcttgta aaaggtgcag atattccggt 1439761 agatattaca gatcaaaaag tcattctcgt tgatgatgtt ctgtataccg gaagaacagt 1439821 cagagcagga atggatgcgc ttgttgatgt aggcagacct tcctccattc agcttgcagt 1439881 gcttgtggac agaggacacc gggagctgcc gatccgagcg gattatatcg ggaaaaacat 1439941 cccgacatca aagtctgaaa aggttatggt acagcttgat gaggtagacc aaaacgatct 1440001 cgtcgccatt tatgaaaacg aataatagat caccttttta agggcaatcc agagaggttg 1440061 caaagaggtg cacaacaaag gcccaaaaag tattcggcag gtctttgtat gcctctttgc 1440121 gtaaaaaagc aaagaggttt ttttatacag tcattgagtc atcctaaaat gaaagtcaac 1440181 aatcaggggg aaatcatcat gagtaagaaa aaagtaaatt taggggtcag ggatgtcccg 1440241 acacctttct cttgggtttc attcagcctt cagcatttgt ttgccatgtt tggctcaacc 1440301 attttggttc cgaagctcgt cggaatgagt cctgctgtgg cgttggtgac aagcggcatc 1440361 ggaacactgg cgtaccttct tattaccaaa ggacaaattc cggcgtatct cggttcatcc 1440421 ttcgccttta tttctccgat cattctggta aaagcgaccg gcgggccggg agcggcaatg 1440481 gttggagcgt ttcttgcagg gctggtgtac gggctgattg ccttattgat taggcagctt 1440541 ggaacaggat ggctgatgaa gattctcccg cctgtagtcg tagggcctgt tattatcgtc 1440601 atcgggctgg gactggcaag cactgcagta aacatggcga tgtatgctga tccgaacgcg 1440661 agtgagttgg tctacagctt aaagcacttt agtgtcgcag gagttacgct ggcaattacg 1440721 attatttgtg cgattttctt acgagggttt ttaagcctga ttccggttct gatcggaatc 1440781 atcggcggat acctgtttgc ccttactcaa gggattgtca acttccagcc ggtgcttgac 1440841 gcgaaatggt ttgcagtgcc tgaatttatc attccgttca aagattattc accgtcagtt 1440901 acgctcggca tcgcagccgc aatggttcct gtcgcatttg tcacaatgtc agagcatatc 1440961 ggccaccaaa tggtgctgag caaggttgtc ggacaagact tcattaaaaa gccaggtctt 1441021 catcgctcta ttatgggtga cagtgtggcg acaatcctcg cttccctgat cggcggccct 1441081 ccgacaacga cttacggaga aaacattggc gtgctggcca tcacaagagt attcagcgtc 1441141 tttgtcatcg ggggcgcggc agtgattgcc ctttgcttcg gctttatcgg caaaatttca 1441201 gcgctgatca gttcagtgcc gtcagcggtc atgggaggcg tctccttcct gctgttcgga 1441261 atcattgctt caagcggcct gagaatgctg attgacaaca aaattgatta tgaaaacaac 1441321 agaaacctca ttattacatc agttatcctt gtcatcggtg taggaggcgc ttttatccaa 1441381 gtgtctcagg gcggattcca agtgtcagga atggcgcttg ccgcaattgt cggtgtcatc 1441441 ttaaacctga ttcttccgca ggcgaaggaa gagcaggcag acacatctga acaacatcat 1441501 atttaaaacc ttttaatgaa agtccagaga ggcttggaag ggttatgaag agaaggaagc 1441561 ttcaatgctg ccctctattt aaccataccc cgagtctatc ttagaccggg gttttttttc 1441621 agccttaagt tgaaaagaga ggggaaagaa catgaagcat ttaacgacga tgagtgaact 1441681 tagcactgag gaaatcaaag atttgcttca aacagcacaa gagctcaaaa gcggaaaaac 1441741 agacaatcag cttacaggaa agtttgcagc aaacctgttt ttcgaaccga gcacgagaac 1441801 gcggttcagc tttgaggtcg cagaaaaaaa gctgggcatg aatgtgctta accttgatgg 1441861 aacaagcaca agcgtgcaaa aaggcgaaac cttatatgac acgatccgga cgcttgaatc 1441921 aatcggtgtg gacgtctgcg tcatcaggca cagtgaggat gagtattatg aagagcttgt 1441981 cagccaggtg aacattccga ttctgaatgc gggagacggg tgcggccagc atccaacaca 1442041 atcactgctt gatttaatga cgatttatga agagttcaat acgtttaaag ggcttaccgt 1442101 ctccattcac ggcgacatca agcatagcag agtggcaagg tcaaatgcgg aagtgttgac 1442161 aagattgggt gcccgggtcc tattttccgg cccttcggaa tggcaggatg aagaaaatac 1442221 attcggcacg tatgtctcaa tggatgaagc agttgagtct tccgatgttg tcatgctgct 1442281 gcgcattcaa aatgaacgac atcagtccgc tgtcagtcag gaaggctatt taaacaaata 1442341 cggcttgacc gtagaacggg ctgagcgtat gaagcggcat gcgatcatca tgcatcctgc 1442401 tccggtaaac agaggagtgg agattgatga cagcttagta gaaagcgaaa aatcaagaat 1442461 cttcaagcaa atgaaaaatg gcgtatttat cagaatggca gtgatacagc gtgccttaca 1442521 aaccaatgtg aaaagaggag aagcagcgta tgtcatatct cattaaaaac ggctggatac 1442581 taaacgaaaa tggtgaaaaa acacaagcgg atatccgagt gactggagaa accatcaccg 1442641 caatcggcaa gcttgatgca acggataatg aaacggtaat tgatgcaaaa ggtttgctcg 1442701 tttcacctgg gtttgttgat ctccacgtgc atttcagaga gccgggcgga gagaaaaaag 1442761 aaactattga aaccggggca aaagcagcgg cgcgcggcgg ctatactaca gtagcagcaa 1442821 tgccgaatac gcggccggtt cctgatacaa aggagcagat ggaatgggtg caaaacagaa 1442881 ttaaagaaac atcatgcgta agagttcttc catatgcatc cattacgatc agacaaatcg 1442941 gcgatgaaat gacaaacttt gaagcgttaa aagaagccgg ggcatttgct tttacagatg 1443001 acggcgttgg tatacagaca gcaggaatga tgtatgaagc gatgaaacgg gcagccgcaa 1443061 ttgacaaagc gattgttgca cattgcgagg acaactcctt aatttacgga gggagcgtac 1443121 atgaggggac attctccaaa gcgaacgggc taaacggcat tccttctgtg tgtgaatcgg 1443181 ttcatattgc tcgcgatgtg ctgctggctg aggcggcaaa ctgccattat catgtatgcc 1443241 atatcagcac aaaagaatct gtcagagttg tacgcgatgc gaaaaaagcg ggaatcagag 1443301 tgacagcaga agtatcgccg catcatttgc tgctttgtga tgaggacatc ccggggctgg 1443361 acacaaacta taaaatgaat cctccgctcc gcagcccaga agacagagct gctttaattg 1443421 aaggtctttt agacggaaca attgatttta tcgcaacaga ccatgcaccg catacggaag 1443481 aagagaagaa cacagaaatg aagctggcgc cattcggaat tgtcggctta gaaacagcat 1443541 tcccgcttct ttacacacac tttgtcaaaa atggcagctg gtcactgaag cagctgattg 1443601 actacatgac aatcaagcca tgcgaagcgt tcggtctccc atatggaaca ttacaaacgg 1443661 ggcaagctgc ggacattacg ttaatcgatt tagaaaaaga agcagttata gacaaagaga 1443721 catttttatc aaaaggaaaa aatacaccat tcaacggcat cagttgcacc ggctggccgg 1443781 tcgctacaat tgcggcaggg aagcttgctt atgaagaggg gagacttgtc aaatgaagag 1443841 acgattagta ctggaaaacg gagcggtatt cgagggagaa gctttcggaa gcttagaaca 1443901 caacatggga gaagtcgttt ttaatactgg gatgacaggc tatcaggaaa ttttatctga 1443961 tccttcttac tgcggacaga tcgtaacatt aacatacccg cttatcggaa attacggcat 1444021 taaccgtgat gattttgaat ccattacccc ttttgtcaaa gggctgatca tcaaagaatt 1444081 atgtgagctg ccttccaact ggcgttcagc atacacctta gacgagtatt taaaaatgaa 1444141 aaacattccc ggactccagg gaattgatac aaggaagctg acaagaatga tccgcacggc 1444201 aggcgcgcta aaaggaacat tcgcttcatc tgatgaagat atcgaagcag tgctgaaaag 1444261 actgaacgaa acggaattgc caagaaatca agtatcccaa gtatcagcaa aaacagcata 1444321 tccgagcccg ggaagaggca aacgcattgt cttggttgac ttcggcatga aacacgggat 1444381 tctaagagag ctgaacaaac ggaaatgtga cgtcatcgtt gtgccttaca acattacagc 1444441 ggaagaggtg cttcagctga aaccggacgg tatcatgctt tctaacggac ctggagaccc 1444501 gaaggatgtg cctgaagcga ttgaaatgat taaaggtgtt cttggaaaag tgccattatt 1444561 cggaatatgt ctcggccacc aattattcgc gctggcgtgc ggggcgaata ctgaaaaaat 1444621 gaaattcggc cacaggggct caaaccaccc ggtaaaagag ctggctacag gaaaagttgc 1444681 cttaacatct caaaaccatg gatatacagt ttcgtctatc agtaaaacag aactggaagt 1444741 gacgcatatc gcaattaacg acgatacgat tgaagggctg aagcataaaa cattgccggc 1444801 atttacggtt caatatcatc ccgaagcctc acctggtcct gaggatgcca accatctatt 1444861 tgacagattc atcgaaatga tcgaaacaac agagaaagaa ggggaagcgg tatgccaaaa 1444921 cgcgtagaca ttaacaaaat tttagtaatc ggatctggac cgatcatcat cggccaagca 1444981 gcagaatttg actatgcggg aacacaagcc tgtcttgctt tgaaagaaga aggctatgaa 1445041 gtcatccttg tcaactcaaa ccctgcaacg atcatgacag atacagaaat ggctgaccgg 1445101 gtttacatcg aaccgctcac acctgaattc ctgacacgaa tcatcagaaa agagcgcccg 1445161 gatgccattc ttcctacact cggaggccaa accggtttga atcttgcggt tgagctttct 1445221 gaaagaggcg ttttggcaga atgcggcgtc gaagtgcttg gcacgaaact gtctgcgatt 1445281 cagcaagctg aagaccgtga cttgttcaga acattaatga atgaactgaa tgaaccggtg 1445341 cctgaaagtg agattatcca ctcccttgaa gaagcagaaa aattcgtcag tcaaattgga 1445401 ttccctgtca ttgtccgccc ggcatataca ttaggcggaa caggcggagg catctgctcg 1445461 aatgaaacag agctaaaaga aatcgttgag aacggcttga aattaagccc ggtacaccaa 1445521 tgtctgcttg aaaaaagcat cgccggctat aaagaaatcg agtatgaagt catgagagac 1445581 agccaggatc acgccattgt cgtttgtaac atggaaaaca ttgatccagt tggaatccat 1445641 actggagaca gtattgttgt cgcgccgagc caaacgctca gcgatcgcga atatcagctc 1445701 ttgcggaatg tatcgttaaa actgattcgc gcgcttggga tcgaaggcgg atgtaatgtc 1445761 cagctcgcct tagatccaga cagcttccaa tattacatta ttgaagtaaa tccgcgtgtc 1445821 agccgttcat ctgcccttgc atcaaaagca acggggtacc cgattgcaaa gctcgctgct 1445881 aaaattgcag tcggactttc attagatgaa atgatgaacc cggtgacagg aaaaacatat 1445941 gcagcatttg aacctgctct tgactatgtc gtatccaaaa ttccgcgctg gccgtttgat 1446001 aagtttgaat cagcaaacag aaagcttggc acgcaaatga aagcgacagg tgaggtcatg 1446061 gcaatcggcc gcacgcttga agagtcattg ctgaaggcag tgcgatcact ggaagcggat 1446121 gtgtatcatc ttgaattgaa ggacgccgct gacatttcag atgagcttct tgaaaagcga 1446181 attaaaaagg ccggtgatga acgcttattc tacttagctg aagcgtacag aagaggctac 1446241 acggtagaag acctccatga attttccgct atcgatgtct tcttcttgca taagctgttc 1446301 ggaatcgtac agtttgaaaa agaattgaag gccaatgcgg gcgatacaga tgtgctgaga 1446361 cgggcaaaag aactcggctt ctctgatcag tacatcagcc gtgaatggaa aatgaaagaa 1446421 tctgagcttt acagcttgag aaaacaagcg gggattgcgc cggtattcaa aatggtagat 1446481 acatgcgcgg cggaatttga gtcagaaacg ccatacttct atagcacata tgaagaagaa 1446541 aatgaatctg tcgttacaga taagaaaagt gtgatggtgc ttggttcggg tccgattcga 1446601 atcggtcagg gtgtcgagtt cgactatgcg acggttcact ctgtatgggc aattaaacaa 1446661 gcaggctatg aagccattat tgtcaacaac aacccggaaa ccgtttcaac agacttcagc 1446721 atctcagaca agctgtattt tgaaccgctt acgattgaag atgtcatgca catcattgac 1446781 ctcgaacagc caatgggcgt tgtcgtacaa tttggcggac aaactgcgat taaccttgct 1446841 gacgagcttt ctgcacgcgg agtgaaaatc cttggaactt cattagaaga tttagaccgt 1446901 gccgaagacc gggataaatt tgaacaagcg cttggagaac ttggtgttcc tcagccgctt 1446961 ggcaaaacag cgacatcagt taatcaggcg gtaagcatcg caagtgatat cggttatccg 1447021 gtactggtac gcccttccta tgtacttggc ggccgggcga tggagattgt ttaccatgaa 1447081 gaggaactgc ttcattacat gaaaaatgca gtcaaaatca atccacagca ccctgtatta 1447141 attgatagat acttgaccgg aaaagaaatt gaagtcgatg cagtatccga cggtgaaaca 1447201 gtcgtcattc cgggaattat ggagcacatt gaacgtgcgg gcgttcactc cggagactca 1447261 atcgctgttt atccgcctca gtctctcaca gaggacatta agaaaaaaat tgaacaatac 1447321 acgatcgcat tggctaaagg gctgaatatt gtcggtttgc tcaatattca attcgtcttg 1447381 tcgcaaggcg aggtgtacgt gctagaagtg aatccgagat caagcagaac cgtaccgttt 1447441 ttaagcaaaa ttacgggtat cccaatggcg aatctcgcaa caaaaatcat tcttggtcaa 1447501 aagctggctg cgtttggcta tacagagggc cttcagcctg aacagcaagg tgtatttgta 1447561 aaagcgccgg tcttctcctt tgccaagctg agaagagtgg atattacgtt agggcctgaa 1447621 atgaaatcaa caggtgaagt catggggaaa gattcgacac ttgaaaaggc gctctacaaa 1447681 gccttgatcg cttcaggtat tcaaatcccg aactacggtt ccgtgctttt aacagtagct 1447741 gataaggaca aagaagaagg gcttgccatt gctaagcggt tccacgcgat cggctacaac 1447801 attttagcga cggaaggaac ggcaggctac ctgaaagaag cttccattcc agcgaaggtc 1447861 gtcggaaaaa tcggtcagga tggcccgaac ttgcttgatg tcatcagaaa cggagaagcg 1447921 cagtttgtca tcaatacgct gacaaaagga aagcagccgg caagagacgg ttttagaatc 1447981 agacgtgaat cagtagaaaa tggtgttgcc tgcctaacat ctttagatac ggcagaggcg 1448041 atattgcgag tgctggaaag catgacattc cgtgctgatc aaatgccggc agtcaacaca 1448101 aatcaggagg cggcagtcac tatatgaaaa aagcgtattt gacagtatgt tctaaccagc 1448161 aaattgcaga ccgggtgttt caaatggttc tgaaagggga gcttgtccaa gggtttacaa 1448221 cccctggaca gttccttcat cttaaagtga gcgaagcggt tacgcctctt ttgagaaggc 1448281 cgatcagcat cgcagacgtc aactttgaaa aaaatgaagt caccatcatt tatcgggtag 1448341 atggggaagg gacaagactc ttgtcactga agcagcaggg agaacttgtg gatgtcctcg 1448401 ggcctttggg aaatggcttt cctgttaatg aagttcaacc cggaaagacg gctttgctgg 1448461 taggaggcgg agtaggtgtg ccgcctctcc aagagctgtc gaaacgcttg attgaaaaag 1448521 gggtaaatgt catccacgtt ttaggattcc aatcggcaaa ggatgttttt tacgaggaag 1448581 aatgccggca gtacggagac acgtatgtgg caacagctga cggaagctac ggggaaaccg 1448641 gatttgtcac agatgtgatt aaacggaaaa agctagagtt tgatatcctc ctcagctgcg 1448701 ggccgacacc gatgctcaag gcgttaaaac aggaatatgc ccataaagaa gtatatctgt 1448761 ccatggagga acgaatgggc tgcggaatcg gcgcatgctt cgcgtgtgtg tgccatacaa 1448821 acgaaagtga gacatcctat gtaaaagtat gtctcgacgg gcctgtattt aaagctcagg 1448881 aggtggcgct gtaatgctag aggtgaaatt gccgggactt gatttgaaaa acccaatcat 1448941 tcctgcatca ggctgcttcg gttttggaaa agaattttca cgtttttatg atttgtcttg 1449001 tcttggagct atcatgatta aggctacgac aaaggagccg cgctttggga atccgacgcc 1449061 gcgggtagct gagactggtg ctggaatgct caatgcgatc ggtctccaaa atccggggct 1449121 ggatagtgtg ttgcatcatg agctgccgtg gcttgagcag tttgatacac cgatcattgc 1449181 caatgtcgca ggttctcaag tcgatgatta tgttgaagtc gcagaacata tcagcaaagc 1449241 gcctaatgtt catgctcttg aattgaatat ttcctgcccg aatgtgaaaa caggcggaat 1449301 cgcttttggc acgaatcctg aaatggctgc cgatttgaca aaagcggtga aagaggtttc 1449361 ggatgtaccc gtttatgtga agctatcccc gaacgtggct aatatcacag aaattgcatt 1449421 agcgatcgag gaagcgggag cggacggtct tacgatgatc aacacactaa tcggcatgag 1449481 actcgattta aaaaccggca aaccgatatt agcgaataaa acagggggac tttcgggccc 1449541 tgctgtgaag ccggttgcca ttcgcatggt gtatgaagtc agccagatgg tcaacatccc 1449601 gattatcgga atgggaggcg tgcaaacggc tgaagatgcc ctggaatttc ttctcgcggg 1449661 agcaagcgca gtcgctgtcg gaacagcaaa ctttgtgaat ccttttgcat gtccagagat 1449721 tattgaacag ctcccatctg ttttgctcca atacggctat caatcaattg aagaatgcat 1449781 cggaaggagc tggaatcatg aaaaacaacc tgcccatcat cgcgcttgat tttgcgtcag 1449841 ctgaagaaac acttgcgttc ttagcgcctt ttcagcaaga accgttattt gtaaaggttg 1449901 ggatggagct tttttatcaa gaagggccat ctatcgtgaa acaactaaaa gaaagaaact 1449961 gcgagctatt tttagatcta aagcttcatg acatcccgac tactgtaaac aaagcgatga 1450021 agcgccttgc cagtcttgga gtagacctcg tcaatgttca tgctgccggg ggcaaaaaaa 1450081 tgatgcaggc agctctcgaa ggcttagaag aaggtacgcc ggctggaaaa aaacgtccgt 1450141 cacttatcgc ggtaacccag ctgacaagca catctgaaca aatcatgaaa gatgaactgc 1450201 tgatcgaaaa gtctctgatt gatacggttg tgcactacag caaacaggcg gaagaaagcg 1450261 gactggatgg agtggtctgc tctgttcatg aagcaaaagc catttaccaa gcggtgtcgc 1450321 cttcatttct gactgtcact ccggggatca gaatgtcaga ggacgctgcg aatgaccaag 1450381 ttcgcgtagc gacgcctgcc attgcaagag agaaaggttc atcagcgatt gtagtaggac 1450441 gctcgattac aaaagcggaa gacccggtaa aagcctataa ggctgtcaga cttgaatggg 1450501 agggaatcaa atcttgaaac aaatcatcgc aaaacatcta ttagacatcc aagctgtatt 1450561 tttacgcccg aacgagccgt tcacatgggc aagcggcatt ttatcaccga tctactgtga 1450621 caaccgcctt acgctatctt tcccagaggt cagaaacgat gttgcttcag gtatcagcaa 1450681 gcttgttaaa gagcattttc ctgaagctga aatgattgcg ggaacagcaa ctgccggtat 1450741 tcctcatgct gctcttgcgg cggaccattt gaatcttccg atgtgttatg tgaggagcaa 1450801 gccgaaggcg cacggaaaag gcaatcagat tgagggagct gtgcaagaag ggcaaaaaac 1450861 agtcgtcatt gaagacttaa tttccacagg aggcagcgtg cttgaagctt gtgcagcttt 1450921 acaagcggcc ggctgtgaag tgcttggtgt cgtctcaatc tttacgtacg gacttcctaa 1450981 agcggaggaa gccttcgcaa aggcagaact gccatactac tcattaaccg attatgatac 1451041 gctcacagag gtcgcgcttg aaaacggaaa tattcattca gatgatctaa aaaagctgca 1451101 aacatggaaa cgaaatcccg agtcaaaaga ttggtttaaa aaataaaaaa taaattcaaa 1451161 tgatgtaaag aggcttcaaa gccttgctgt acttgaaaac aggctgtgag gcctgttttt 1451221 ttattaatcc tataaaaaaa gtcgggttga cttatgttag aattgtgcta aaatttacta 1451281 caaatctaaa aacttatcaa gagcggctga gggactggac ctatgaagcc cggcaacctg 1451341 catagtttgt aaggtgctac ttccagcaaa atgaattcca ttttgaaaga taagggctgc 1451401 atgctgttcc tgtctttctt tccgccggat tgaaagtttt ttattttaag aggtaaaaag 1451461 gctatctgta tatcagcagc cgcgaatcac attacatggg aaaagacaac cggcagaaag 1451521 ctactgtttg tttgtctccg aaaggaggaa agaagaaatg ttaacgtatg ataattggga 1451581 agaaccaacg attacatttc cggaagacga tccttataaa ggagcgctgt cagttttaaa 1451641 atgggcatac ggccattacg gcgatcagct tgtttatgcc tgcagtttcg gaattgaggg 1451701 aatcgttctg attgacttaa tttataaagt gaaaaaagac gcagagattg tgtttcttga 1451761 tacaggactt cattttaaag aaacctatga aacaattgaa cgagtgaaag agcgttatcc 1451821 gggtcttaat atcatcctga aaaaaccaga tctcaccctt gaggaacaag ccgaagaaca 1451881 tggtgacaaa ctatgggaaa gagagccgaa tcagtgctgc tatcttagaa aggtcgttcc 1451941 tttaagagag gcgctttcag gacatccagc ctggctttcc ggcctgcgcc gtgatcaagg 1452001 gccaagccgt gccaatacga atttcttaaa caaagatgaa aaattcaagt cagtaaaagt 1452061 ttgcccgctt atccattgga cttggaaaga catttggaga tatacatccc ggaatgaact 1452121 ggactacaat ccgcttcatg accaaggcta tccaagtatt ggctgtgcgc cttgcacttc 1452181 tcccgctttt acagcagaag atttgcgctc aggcagatgg aatggtatgg cgaaaacaga 1452241 atgcggactg catgaataag gagctgcaaa atggaattag ccgctatttt atttagcttg 1452301 tttttcgcga tgaatattgg tgcaagcggc gctgcagctt cgatgggggt tgcttacggc 1452361 tccggagcca tcaaaaagaa aacttacgct ttgatcctat gcgcagtcgg tgtctttgcc 1452421 ggggcggtca ttggcggagg cgaggttgta aaaacaatca gctccggcat tattcctgag 1452481 cagacgatta cactgacgat tgtttgcatc attattggag ctgctgccct gtcgctcttt 1452541 actgctaatc tgctcggcat tcctttgtcg acaagtgaag taacagtcgg cgcggttgtc 1452601 ggcgtgggag tggcttataa agtattgttt gtgaacaatc ttctgatcat tgtgtcattt 1452661 tgggtttttg tcccgctgtt cgctttcggc ttcacctatt tcgtatctaa gctgtttcgt 1452721 tattttaaga ttgaagtaaa atcttctaaa aagcaaaaaa tcctcggcat tgttttgtta 1452781 gttgccggat ttttcgaagc attctctgcc ggcatgaata acgtggcgaa tgctgttggc 1452841 ccgttagtag ctgccggtgt gcttgatgtc ggaaaaggaa ccttgtatgg aggagctttt 1452901 gttgctcttg gcgcactgtt attaggccgg cgagtgctag aaacaaacgg gaagaaaatt 1452961 acgaggttct ccaaagggga aggcattctc ttatccggta caggagcggg actggtgatc 1453021 atcagttctg tatttgggat gccggtgccc ttggcgcaag tcacgtcatc gtctattatc 1453081 ggaataggca tggcgaaaaa cggtccgaac gtgttccata aacaagttgt tcaaacgatg 1453141 ctgaaggtat ggatcgtatc gccgttttta tctttatcga tttcttatct gcttgtatcc 1453201 ttgtttttaa aagcagatta ttattcgatc tttatcatgg taagtgtgct tttagcggcg 1453261 ggcggtgcca tcagcctgac aaaggccatt cgtaaagaga gacgctcagt ccacgaacaa 1453321 ggcgggggaa tctgatcatt aatctgagta attttataag ttaactagga ggagatggat 1453381 attatgagct tagcaccaca cggaggaaca ttagtaaaca gagtagatga atcatatgat 1453441 gtgagcggca ttcaaaaaga aattgaactt gatttaattt ctttcgcgga tttggaattg 1453501 atcggtatcg gtgcatacag cccgattgaa ggtttcttta atgaaaaaga ttacgtatca 1453561 gtggtcgaaa acatgcgtct ttcttccggc gttgtctggt ctcttccaat cacgcttccg 1453621 gtcgatgcgc aaaaagcagc ggaactgtca cttggtgaaa cggtaaagtt aacgtatgaa 1453681 ggagaaactt acggcgttat ccaaatcgaa gacctgtacg tgcctgacaa acaaaaagaa 1453741 gctgtcaatg tgtacaaaac agatgaacag gagcatcctg gtgttaaaaa gctgttcagc 1453801 cgcggcaata catatgtcgg cggaccgatt acgttgatta aaaaagcttc aaaacagttc 1453861 cctgaattta catttgaacc gtcagaaacg agacgccagt ttgcggaaaa aggctgggaa 1453921 accattgtcg gtttccaaac aagaaaccct gttcacagag cgcatgaata cattcaaaaa 1453981 acggctcttg aaacagtaga cggcttgttc ttgaatccgt tagtaggtga aacaaaatct 1454041 gatgacattc cagctgatgt acggatggaa agctaccaag tgcttcttga tcattattac 1454101 ccgaaagatc gtgttttcct tggtgtcttt ttagcggcga tgcgttatgc aggcccgaga 1454161 gaagcaattt tccacgcgct tgtcagaaag aactacggct gcacacattt catcgtcggc 1454221 cgtgatcatg caggtgtagg cgactattac ggaacatacg aagcacagga actgtttgac 1454281 acatttaaac ctgaagaact cggaattaca ccgctgaaat ttgagcacag cttcttctgt 1454341 aaaaaatgcg gaaatatggg aacagcaaaa acttgccctc atggcagaga gcatcacgtc 1454401 attttatcag gcactaaggt aagaggtatg ctgagagacg gtgtgctgcc gcctgctgaa 1454461 ttcagtcgaa aagaagtagt agaagtgtta atcaaaggga tgaagaaaaa agaagaagta 1454521 ggcgtatctt aaggaggact ggcagtgaca aatcgcgata ttgtatggca tgaagcctct 1454581 atcacaaaag aagagtatca gcaaaaaaac aagcataaaa gctccattct ctggctgaca 1454641 gggttaagcg gctcaggcaa atcaaccatt gccaacgccg ctgcgagaga attgtttgag 1454701 caaggctacc aagtcattgt gctggacggg gataatatcc gtcacggcct aaatagggat 1454761 cttggttttt ctgatgaaga ccgaaaagaa aacatccgcc ggatcggaga ggtggcgaag 1454821 ctttttgttc agcagggaac cattgtgatt actgctttta tctctccttt ccgcgaggac 1454881 agacaacagg ttcgcgagct tgtggaagcg ggcgaattta atgaagtcta cattaaatgc 1454941 gaccttgata tttgtgaaca aagagatccg aaagggcttt acaaaaaagc aagaaacggc 1455001 gagattccgt tctttacagg aattgattct ccttatgaag aaccggaagc tccagagctc 1455061 gttcttgatt caggacagca tgaccgtgaa gcgtgtaaaa atcagctgat cgagtttgtt 1455121 aaacaaaaat tgagctgaat atgatctgct gcgttcttct cagatgccgg aatgcaagcg 1455181 agaacatcat cacagcgaat cttctggaag aactcgaata gatcggggga aatacgatgg 1455241 ggaaagtata tattgtagga gcgggtcccg gtgaccctga tctgctgaca attaaagcgc 1455301 tgaaagccat tgaaaaagct gatgtcatct tatatgacag attagtaaat aaagagattt 1455361 tacaatatgc caaagagcaa gcagacctga tctactgcgg gaagcttccg gattttcata 1455421 cgatgaagca ggaaaccatc aatcgatttc ttgtgaagta tgcgcaaaaa gggaaaatgg 1455481 ttgtcagact gaaaggcgga gacccttttg tgttcgggag aggaggggaa gaagcggaat 1455541 gcctctctga aaatggaatt ccgtttgaaa tcattcccgg cattacgtct ggaatcgcgg 1455601 cagccgctta tgccgggatt cctgttaccc atcgggatgc gggctctaac gtcgcttttg 1455661 taacgggtca ctataaaaaa gaagaagatt ttgaggaaaa gtggaaagcg ctggctacag 1455721 gaattgatac acttgtcatc tatatgggta tcaaaaacgt gcagcagatt gaaagaaaac 1455781 tccttgaaaa tggccgggac ggttctacgc cagcagcctt tattcattgg gggacaacgg 1455841 acaagcaaaa atctgttttt tgtacagttg acaccctttc agaaacggtg ataaaagaaa 1455901 acattacaaa tccgagttta attgtcattg gaaatgttgt aaattatcac tataagctgg 1455961 aatggtttga atctgaacta aaaaaacaag atttaagcga ggcgttgtaa aaatgaaaca 1456021 agcaatttta tatgtcggcc acggcagccg ggtcaaaaaa gcgcagcaag aagccgcagc 1456081 ctttttggaa ggatgcaagg cccacatctc tgtgccagta caagaaatca gctttttaga 1456141 gcttcaggag ccgacaattg agacaggatt tgaagcatgt gtgaagcaag gtgccactca 1456201 tatcgcagtg gtgcctctgc ttcttttaac agctgcgcat gcaaaacatg atattccgga 1456261 agaaattgtc cgtgttgcat ctcgatatcc atcagtccgt atttcatacg gaaagccgat 1456321 cgggattgac gaagaagtag tcaaggctgt atatcaccga atgaaagaca taggtgttcc 1456381 gtatgaaaat gccagagtgg tgctcatcgg aaggggaagt tcagatccag acgtcaaaag 1456441 agacgtaacc ggaattgcta atcttcttca ggaaatggtt ccagtgaagg aagtcattcc 1456501 gtgctttttg acagcatgcg gccctaatta caaagaggtt ttttcagaac ttgaaaaaga 1456561 tgacggcata acaaccttta tcgttccata tttgcttttt acgggtatgc tgatgaatga 1456621 aatcgaacga gaggttcaga aattaaaagc ccataatccg aacgtctacc tctcttccta 1456681 tatcggtttt catcctcatg tgaaaaacgc atttttgaac cgtgtgagag aaactgcggc 1456741 aaattctgag ggacaatttg attttgatgg aggttcatat gcttccgctg cacattagcc 1456801 tggaaaagaa gaaggttgtg attgcggggg gcggaagcat cgctctcaga aggctgaaaa 1456861 cggtgatttc tgagggagct gatataacgc ttgtcagtcc ggatgtggaa ccggaaatca 1456921 agcaaatggc agaagagcgg cgtatcaaat gggaaaaacg gacaattgaa aaagaagatt 1456981 atctcaatgc tttcttcatt attgctgcga cggataatgc ggcagtgaac aaagaaattg 1457041 cccaatccgc ttcgcctttt cagcttgtca attgtgtcag tgacgctgag cttggcaatg 1457101 tatatatgcc gaaaatcgta aaaagagggc atgtcactgt gtctgtttct acaagcggag 1457161 ccagtccaaa gcacacgaaa gagcttgctg aaaacgtgga taagctgatt gacggcgatt 1457221 ttgttgctga agtgaacagg ctttatcaga tgagaagaaa gaaataagcc agagcataca 1457281 aatgctctgg cttttcttta tgcggctcag ctttttttga gcttgatgac agtatcagca 1457341 tcaggcgtga caaagacggt atgctggctg tcataagtga cgaaaccggg tttcgcgccg 1457401 tttggttttt tgacatgcct gatttttgta taatctacag gcactgaact tgaatcttta 1457461 gcttttgaaa aataagctgc aattgtcgcg gcttccatga ttgtttgctc atcaggttcg 1457521 ctgcttctga tcacaacgtg ggagccggga atgtccttcg tgtgaagcca gatatcgtct 1457581 ctggccgcca ctcttgtcgt taaatattca ttttgacgat tgttcttacc cactaaaatt 1457641 gtcagccctg aggtggattc atatgtttct aacaccggat tgtgcggttt ttgctttttc 1457701 tggccttttt gctgcttagg gcgtaaatat ttgccctcaa caagctcttc cctgatttcg 1457761 ctgatatccc ggggagaagc ggacgaaagc tgctgaatca gctgatcaaa atattcgatc 1457821 tcttcctgtg ccagcctgat ttgctcctcg acaactgcga ccgaattttt cgctttctga 1457881 tacttcgtga aataggcctg tgcgttttca gaaggcgttt tgttcgggtt taaaggaatc 1457941 gtgattgtcg ggctttcttc atcataataa ttgatgacct cagcctgttt atcacctttt 1458001 ttcagcatat ataaattagc ggttaaaagc tctccgtaaa gctgaaattc cttcgcgttt 1458061 tccgaatact ccagggtttt ctctaatttt ttgattttgt tggcattctt cttccgttcg 1458121 ttcacaacaa aacgctcaag atcctgagcc tgttgcttaa cccggtctcg ttcagctttt 1458181 ccgaaataaa aacggtcgag cagttcgctt aatgaatcaa aacggcgcgc ttcgcccttt 1458241 agatgagtca gctccagcag ataaaaatat tcctttccgt ttacagtcgt aatgttggga 1458301 atgaaacggt gctctttcac ttcggcaaac agtgccagca acgcttttgg cagtgtgact 1458361 ttgttggcaa ggcctgctct gtgaaccgct tctttggcga aaagcggaga cacgcctgaa 1458421 aagtggtcga caatttgttt atcaagcctt ccttcttgaa agctgaggtg acgcaaaata 1458481 tcatcttctg acgcctcaag aggcgatatt ttgtcctgag caggcggaag cttataatct 1458541 tggccgggca gtactgtacg gtagctgttc attgacggtg ataaatgctt aagtccgtcg 1458601 ataatcacat tttctgctgc gtcagtcaaa atgatattgc tgtggcggcc cataatttct 1458661 acataaagct ttcgtacggt ttcatcgcca atttcgtttc ggcttttgat atgaaaaatc 1458721 ataatgcggt ctaagcccgc ttgttcaatt ttctcaatga atccgccttc gatatgcttt 1458781 ctcagcaaca tgcaaaacat tggcggttcg cttggatttt cataagcttg tgccgtgata 1458841 tgcacccgtg aatagctcgg atgtgccgat aataatagtt tttggttttt tcccttggca 1458901 cggatgtgga aaatcacatc gtgcttatat ggctgatgga tttttgtaat tcgtccgccc 1458961 attattttct cgttaagttc gtgtgtcatt ccgtatgtaa acatgccatc aaacgacata 1459021 tgcaatacac cctctcattc ttcctgcatt cgataattat agcatgaaat gggacgagtc 1459081 agaataagca tgcttataga gtgatatctc tataagagag caggggagtg gacgagcgga 1459141 atgaagtttc atgaaatggg acaaacagat ttactagagg caaccaatac gtccatgaaa 1459201 caaggattaa cagaaaaaga ggtaaaaaaa cgccttgaca agcatggacc aaacgagctg 1459261 caagaaggga aaaaaacttc agcgcttctc ttgtttttcg cgcagttcaa agattttatg 1459321 gtgcttgtgc ttctggcggc aacgttaatc tcaggatttc ttggtgaata tgtagatgcg 1459381 gttgcgatta ttgcgattgt gtttgtgaat ggcatactcg gtttctttca agaaaggcgt 1459441 gctgagcaat ctcttcaggc tttaaaagag ctttcaacac cgcacgtcat ggcactcagg 1459501 gaaggaagct ggacaaagat tccttctaag gaactggtgc cgggtgatat tgtgaaattt 1459561 acgagcgggg acagaattgg cgcagacgtt cgaattgttg aagcgagaag ccttgaaata 1459621 gaagaatcag cgctaaccgg ggaatcaatc ccggttgtga agcatgctga taaattgaaa 1459681 aaaccggatg tttcactcgg cgatattacc aatatggcat ttatgggtac gattgtgacc 1459741 cgcggcagcg gtgtcggggt tgtcgtcggg acaggaatga atacggctat ggggaaaatt 1459801 gccgacatgc ttgaatcggc agggacattg tcaaccccgc tgcaaagaag actggagcag 1459861 ctcgggaaga ttttgattgt tgttgcattg cttctgaccg tacttgtcgt tgctgtcggt 1459921 gttattcagg gtcatgatct gtacagtatg tttttagcag gtgtctcgtt agcggtagcc 1459981 gctattccgg aggggctgcc ggcgattgtg acagtggcgc tttcgcttgg tgtacagagg 1460041 atgattaaac aaaaatccat tgttagaaag cttcctgctg ttgaaacgct tgggtgtgcg 1460101 tctatcattt gctcagataa aacagggaca atgacccaaa acaaaatgac agtgacgcat 1460161 gtctggtccg gagggaaaac atggagagtg gcaggggccg gctatgaacc gaaaggaagc 1460221 ttcacactaa acgaaaaaga gatcagtgtc aatgaacata agccgcttca gcagatgctt 1460281 ctgttcggag cgctttgtaa caactccaat attgagaaaa gagacggcga atatgtgctt 1460341 gacggagatc cgacagaggg agcgctgctc accgcggcaa gaaaaggcgg tttttcaaag 1460401 gagtttgttg aatctaatta cagagtgatt gaagaatttc cgtttgattc cgcacggaaa 1460461 atgatgactg tcatcgtaga gaatcaagac agaaagcgct atatcattac aaaaggtgcg 1460521 ccggatgtac tcatgcagcg atcttcccgt atttattatg atggctcagc ggctcttttt 1460581 tcaaatgaaa gaaaagcaga aacagaggcg gtattaagac atttggcatc acaggcgctc 1460641 agaacgatag cggtcgccta caggccgata aaagcaggcg aaacaccgtc aatggagcag 1460701 gcggaaaaag atctgaccat gcttggcctt tcaggtatca ttgatccccc gcggccggaa 1460761 gtcagacagg cgattaaaga atgccgtgaa gcgggaatta agaccgtcat gattacaggt 1460821 gatcatgtag aaaccgctaa agcgatagcg aaagacttgc gcctccttcc gaaaagcggc 1460881 aaaatcatgg acggcaagat gctgaatgaa ctttctcaag aagagctttc tcatgtggtg 1460941 gaggatgtgt atgtatttgc ccgcgtttcc cctgaacata aactaaaaat cgtaaaagcc 1461001 tatcaggaga acgggcatat tgtggcgatg acgggagacg gcgtcaatga tgctcctgcc 1461061 attaaacagg ctgatatcgg cgtctctatg ggcattaccg ggacagatgt ggccaaagaa 1461121 gcatcatctc ttgttctcgt ggatgataat tttgcgacga ttaaatcagc gataaaagaa 1461181 ggcaggaaca tctacgaaaa tatcaggaag tttatcagat acctgttggc gtctaacgtc 1461241 ggagaaatcc ttgtcatgct gtttgcgatg ctgcttgccc ttcctttacc gctggttccg 1461301 attcagattt tgtgggtcaa cttggtgacg gacggattgc cggcaatggc gctcggcatg 1461361 gatcagccgg aaggagacgt catgaagcgc aagccccgtc atccgaaaga aggggtattt 1461421 gcccgcaagc taggatggaa ggtcgtttcc agaggatttt taatcggagt tgccactatt 1461481 ttagcgttta tcattgtgta ccaccgcaat ccggaaaact tggcttatgc ccagacgatc 1461541 gcgtttgcca cattggtgct cgctcagctt attcacgtgt ttgactgccg cagcgaaact 1461601 tctgttttct ctagaaatcc gtttcaaaac ctgtatttaa tcggcgcggt attgtcatcc 1461661 attttgctga tgcttgtagt aatctactat ccgccgcttc agccgatttt ccatactgta 1461721 gccatcacgc cgggggactg gatgctcgtc atcggtatgt ccgccatccc tacttttttg 1461781 ctggcggggt cacttttaac aagaaaaaaa taaattcata tgatataatc ttaggggtaa 1461841 tagcgtgtct attgcccttt tattatgaga acagggaaga attgggtgtt ttaaaatgat 1461901 acgaagtatg acaggcttcg gcagtgcaag caaaacacaa gacgatctct ctgtaagcgt 1461961 tgaacttaaa tctgtgaact acagatttaa agaagtgaac gctcgtttgc caaggccttt 1462021 gctatatttt gaagataagc tgaaacagac cattctgcag catattcagc gcggaagaat 1462081 tgagcttttc gtatccgttg acagcgatat gcttgttgag aaaaggcttg aaattgattg 1462141 gccgctgctc gatgagtttg tcgcagccgc gagagatatg aagaagcggt atcaattgtc 1462201 tgcagagccc gatgtaatgg atttctttaa gcttgatcat gtcgtccagg ttcatgaaga 1462261 acagacgcaa aatgacaagc tggaggcgtt gatcatcgat gctgcagaag aagcggtaaa 1462321 aggtctctgt gaaatgcgtg aaaaagaggg gctgctctta gcgaaagact gcctgatgca 1462381 tattgatcag cttgaagagc tggtgagaga aactgaattg ctggctgcag atgtcgtatc 1462441 tcgttaccgg gaacggctgt atgccagaat caaagaatgg actgaagacg tattagacga 1462501 gagccggctt gtaacagaat gcgctatttt tgcagaccgc tctgatatca ctgaagagat 1462561 tacaaggctg aagagccact tcgcccagtt tcgtgatata ttagctagtg gcggagctgt 1462621 cgggcgcaaa ctcgactttc ttgttcagga gctcaatcgg gaagcaaata cgatcggctc 1462681 aaaagcaaat gatcatcaga tcacaaagct tgtcgttgaa atgaaaagtt ctattgaaaa 1462741 aataaaagaa caagtgcaaa atatagaata gtgactgtgc gtattgttta cagacggtct 1462801 tactaggcta aactagagac gtctatttta cagggggaac gtagaagatg acgattaaac 1462861 tgattaatat cggatttggc aatatcatct ccgccaatcg gatgatttcg attgtcagcc 1462921 cggagtctgc gccaatcaaa cggatgattc aggatgcaag agaccgcgga atgctaattg 1462981 acgctacata cggacgaaga acccgtgcag ttgtcgtcat ggatagtgat cacattatct 1463041 tatctgccgt ccagcctgag acagttgcac acagactttc tgttaaagaa gaaattatgg 1463101 atgaagggca ggggtaattg ccgcatgaaa gaaagagggt tattaatcgt tctctcaggt 1463161 ccctcaggag ttggtaaagg aacggttcga caagcgatct tttcgcagga agacacaaaa 1463221 tttgaatatt cgatttcagt aaccacaaga agtccaagag agggcgaagt gaacggagtc 1463281 gattattttt tcaaaacaag agacgaattc gagcaaatga ttgcggacaa caagctgctt 1463341 gaatgggcag agtatgtcgg caattattac ggcacgccag tcgattatgt tgaacagacg 1463401 cttcaagatg gaaaagacgt ctttttagaa attgaagttc aaggggctct tcaagtgaga 1463461 aatgctttcc cggaaggcct gtttattttc cttgcgcctc caagcctttc tgaactgaaa 1463521 aacagaatcg tgacacgagg aacagaaaca gacgctctga ttgaaaatcg aatgaaagcc 1463581 gcaaaagctg agatcgaaat gatggatgct tatgactatg tcgttgaaaa cgataatgtc 1463641 gaaacggctt gcgataaaat caaagcaatc gttcttgctg aacatttgaa gcgtgaacgc 1463701 gttgcaccaa gatataagaa aatgctggag gttgaataat caatgttaga tccgtcaatt 1463761 gattctttaa tgaataaatt agattcaaaa tatacgctgg tgactgtttc tgcgagacgt 1463821 gcccgtgaaa tgcaaatcaa aaaagaccaa atgattgaac atacgatttc acacaaatat 1463881 gtaggcaaag ctttagaaga aattgatgca ggcctgcttt cgtttgaaaa ggaagaccgc 1463941 gaatagtagc acaagtagca acctatatca tgtaggttgt tatttttttc cgtgcggttt 1464001 tgtaaagtgc agagggggag aattcattgc ttaacaatcg aaatgtgtta ctttgcgtga 1464061 gtggaggcat cgctgtttat aaagcctgtg cgttaacgag caagctggtt caggcaggag 1464121 caaatgtcaa agtgattatg actgaatccg cttgccgatt cgtttcaccg ctgacatttc 1464181 aggcattgag ccgccacgaa gtctatacag atacatttaa agaacaaaat ccaagcgtca 1464241 tttctcatat tgatgccgca gactgggccg acttgattat cgtagcgccg gctacggcta 1464301 atgtgattgg aaaactggca aacggcatcg ctgatgatat gctgacgaca acattgttgg 1464361 cagcaacggc tcccgtttgg atcgcgccgg caatgaacgt tcatatgtat gaccacccgg 1464421 cagtcaaacg aaacatttct gttctttatc aggacggtta ttgttttatt gagccaagtg 1464481 agggctattt agcatgcggt tacgtaggaa aaggcagatt ggaagagccg gaaaacatcg 1464541 taaagctggc cgaaaaacat tttgctgaag aaacatccgc tcctttagaa ggcaagcatg 1464601 tggtcattac agccggccca acgcgggaag cgattgatcc tgtccggttt tttaccaata 1464661 aatcgacggg caaaatgggc tacgcactgg cggaggctgc tgttcagctc ggcgcacggg 1464721 taatcttaat ttctgggcct gtttcacttg atcagcctaa aggccttgct gagtttatcc 1464781 ctgttcaatc ggctgcggat atgcgcgaag ctgtgctctc tgtgtatgac gcaagcgata 1464841 tagtcattaa aacagctgcg gtagccgatt ttacgccgaa aacagtattt gaccataaaa 1464901 tgaaaaaaca agacggcggc atgaccttag aactgaaaag aacagtcgat attttgaaag 1464961 aattgggcga gaaaaagaaa gagcagattt tggtcggatt tgccgccgaa acacaagaca 1465021 ttgaacacta tgcacgtaaa aagctcgccg ctaaaaacct tgatttgatt gtggcaaatg 1465081 atgtgaaagc aaatggggcc ggttttggtg ctgatacgaa tatcgtgaca atctttttca 1465141 aagacgggca taaacgcgaa ctcccgatta tgtctaagct cgatgtttct tttgaaatcc 1465201 ttcaggagat cgcagccctc tcaaaacaaa ccggagagcg ctcatgaatt ttgcagaagt 1465261 catcgttgat gtcagcacca aaaatataga caggcctttt gattataaaa tcccagacca 1465321 tctgaagggc atgatcaaaa cggggatgcg ggtcattgtt ccgtttggcc cccgtaagat 1465381 tcaagggttt gtgacagcag tcaaagaagc atctgaccta tcgggaaaat ctgtcaagga 1465441 agtagaggat ttattagatc ttacacctgt tctgacagag gagcttatga ttctgtcatc 1465501 atggctgtca gacaaaacgc tgtcttttaa aataacggcg cttcaagcaa tgctgcctgc 1465561 cgccttaaag gcgaaatatg aaaaagaatt aaaaattgca cacggagccg atcttccgcc 1465621 gcaagtggaa cggctgtttt ctgaaacaaa gacgctgctg tattcagata tacccgatca 1465681 tgagacgctg aaactgattc aaaggcatgt tcaaaaaggg gacattgacg tgacgtataa 1465741 agtcgcgcaa aaaaccaata aaaaaatggt caggcatatt caggcaaatg cgagtaaaga 1465801 agagcttgct aagcaggctg agggattgtc ccgccaagca gcaaaacagc aggcgattct 1465861 tcactttctc atctctgagc cggaaggtgt gaaaattcct gcggcggaat tgtgcaaaaa 1465921 aacggacacg agctctgcaa ccatcaaaac ccttatccaa aaagggcttt tgaaggaaag 1465981 ctatgaagag gtttacagag atccctatca ggacaaaatg ttcaaaaaaa cagagcccct 1466041 gccgctgaca gacgaacaga gggctgcctt cgagcccata cgcgagacat tggacagcga 1466101 tgagcataaa gtgttcctcc ttcacggcgt gacaggaagc ggaaaaaccg aaatttatct 1466161 gcaatcaatt gaaaaagtac tggcgaaagg aaaagaagcc atcgtcctcg taccggaaat 1466221 atcgctgacg ccgcaaatgg tcaaccgctt caagggccgc ttcggctccc aggtggcagt 1466281 catgcacagc ggtttatcca caggagaaaa atatgacgag tggcgtaaaa tccaccggaa 1466341 ggaagtacgg cttgtcgtcg gtgccagatc cgccattttt gctccgtttg aaaatctcgg 1466401 aatgataatc atcgatgaag agcacgagtc ttcctataaa caggaagaaa tgccgcgcta 1466461 tcatgcgaaa gaggtggcaa tcaagcgggc tgagcatcac agctgcccgg ttgtattagg 1466521 gagtgctacg ccgacattag aatcatatgc tagagcgcaa aagggcgtat acgagcttct 1466581 ttcactgaag caccgtgtta accatcgggt gatgcccgag gtttcgcttg tcgatatgag 1466641 agaggagctt agaaacggca atcgctcgat gttttcagtt gaattgatgg aaaagcttga 1466701 agaaacgatt gccaagggtg agcaggcggt gctgttttta aataagaggg gctactcttc 1466761 ctttgtgatg tgcagggatt gcggctatgt cccgcaatgc ccgcactgcg acatttccat 1466821 gacgtatcat cgttacggcc aaaggctgaa atgccattat tgcggacatg aagagcctgt 1466881 tccgcacact tgtcctgaat gcgcaagcga gcatatccgc tttttcggaa cgggaacaca 1466941 gcgagtggag gaagagctga caaaagtgct gccaagtgcg agagtgattc ggatggatgt 1467001 tgacacgaca tcacggaaag gcgcccatga aaaattactg tcagctttcg gagaaggaaa 1467061 agcggatatt cttctcggaa cgcaaatgat cgcgaaaggg cttgattttc cgaatgtcac 1467121 gcttgtcgga gtgttaagtg ctgatacaac acttcatatt cctgatttca gatcggctga 1467181 aaaaacattt cagctgttaa cgcaagtcag cggccgggca ggcaggcatg aaaagcccgg 1467241 ccatgtcatc attcaaacgt atacaccgtc tcattacagt atccagctga cgaaaacaca 1467301 cgattatgaa acgttctatc agcatgaaat ggcgcacagg agagagcaat cctatccgcc 1467361 atactactat ttggctcttg tgactgtttc tcatgaggaa gtggcgaaag cagcggttac 1467421 agctgaaaaa atcgctcatt ttttgaaagc aaactgcgga gctgacacga aaattctcgg 1467481 accaagcgcg tcgccgatag ccaggatcaa agatagatat cgctatcaat gcgtgataaa 1467541 atacaaacag gaaacccagt tatccgcttt attgaagaag atactggaac attataaacg 1467601 cgaaattgaa caaaaacatg taatgatttc aattgatatg aatccttata tgatgatgta 1467661 agatctcacg tcttggaggg taacaaattg gcagtaaaaa aggtcgtcac acatcctgcg 1467721 gaggttttgg aaacacctgc ggaaaccgtg actgtttttg ataaaaagct aaaaaaactg 1467781 cttgatgata tgtacgacac catgcttgaa atggatggtg tcggactggc agcgccgcaa 1467841 atcggcattt taaaaagagc ggccgtcgta gaaatcgggg atgacagagg gagaattgat 1467901 ctcgttaatc ctgaaatttt agaaaaaagc ggcgagcaaa ccggaattga aggatgcttg 1467961 agctttccta acgtctatgg tgatgtcaca cgtgccgatt atgtcaaagt gcgtgcgttt 1468021 aaccgtcagg gaaaaccgtt cattctggaa gcgcgaggct ttttagcaag agccgtgcag 1468081 catgaaatgg accacttaga cggtgtgctg tttacatcta aaataagtaa atactataca 1468141 gaagatgaac tagcggatat ggaaggatga tttgatgacg agaatcgtat ttatgggaac 1468201 gccggatttt tcagttcctg ttttaagaac cctgatagag gacggatatg aagtagtggg 1468261 ggtcgtcaca cagccggacc gtccgaaggg cagaaaaaaa gtactgacac ctcctccggt 1468321 aaaggaagag gcattgcgcc acggcatccc ggttcttcag ccggaaaaag tcagattgac 1468381 agaagaaatt gaaaaagtgc tggcattaaa gcctgacctg attgtaacgg cggcattcgg 1468441 acaaattttg cctaaagagc ttctcgacag tccaaaatac ggctgcatta acgttcacgc 1468501 atcccttttg ccggaactgc gcggcggtgc tccgatccat tattccattc tgcagggaaa 1468561 gaagaaaacc gggattacca ttatgtatat ggtagaaaaa ttggatgcgg gcgatatgat 1468621 ctcaaaagtg gaagtggaca ttgaagaaac cgacaatgtc ggaacactgc acgataaatt 1468681 aagcgttgct ggcgcgaagc tattgtctga aacggttcca aacgttattg ccggcagcat 1468741 atcacctgaa aagcaggatg aagagaaagc gacgtacgcg cctaacatta aaagagagca 1468801 agagctgctc gactggtcca gaacgggcga agagctttac aaccagatcc gcggcttaaa 1468861 tccatggcct gttgcttata cgactctaaa cggacaaaac ttgaaaatat gggcgtcgaa 1468921 aaaaatagcg gcaccaacaa cagctgagcc cggcacagtc gttgcagttg aaaaggaagg 1468981 aattatcgtt gccacaggta acgagacggc tctgttatta accgaactcc agccggcagg 1469041 caaaaaacga atgaaaggcg aagactttgt gcgaggcgct catgttgaag ccggtgatgt 1469101 gttaggagta aacaatgaaa aaaactagtg ttcgtgacat cgcccttgag gcgctgatca 1469161 aattagaaca aaaccaggca tacagcaacc tgctgctgaa atcggtcatt aaatcaaatg 1469221 aactgagtga tcagaacaga gggcttttga ctgaacttgt ctatggtaca ttacaaaata 1469281 agatcgcgct tgattatatg cttaaaccgt ttatcaataa gcctcaaaag gtaaagccgt 1469341 gggtgattca gcttcttcgc ctatccttat atcaaatgga gtatttggag aagattccag 1469401 acagggcagc cattcatgaa gcggttgaga ttgctaaaat ccgcggacac aaaggcattg 1469461 cttcatttgt caacggcgtg ctccgttcta ttcagcgcga aggtgttcca tcctttgacg 1469521 cgatcgaaga tcctgtccgc cggctggcga cagaaacaag ccatccggaa tggcttgtga 1469581 aagagtgggc ggatgcgtat ggatttgaag ctgcggaaaa gatttgccgc atccatctca 1469641 ttccgccgaa acagacgctg cgtgtcaatc aaatgaaagc agacagagct gagctgcttg 1469701 accaaatggc tgctgaggga atcgaagttg aaaaaggcga cctcgctgaa gatgctgtga 1469761 agctcttaaa gggaacaatt gccggaactc atttcttcca aaacggcgaa gtttctatcc 1469821 aggatgagag ctccatgctc gtcgcccgcg cccttgatcc taagtcagat gaaacagtgc 1469881 ttgacgcgtg tgcggcgcct ggcggaaagt cggctcatat cgcagaatta atgaagaaca 1469941 aggggagcgt tacgtcgctt gatcttcaca aacataaagt gaagctgatc aaagaagcgg 1470001 cagatcggct tggcctgaca atcattcatg cggaaacaat ggatgctaga aaagcggggg 1470061 aaacgtttga aaacgaacag tttgaccgaa tattggtcga tgccccgtgc tcaggtttcg 1470121 gtgttatcag aagaaagccg gacatgaaat acacgaaaaa acctgacgac agcgcccgtc 1470181 tagctgaaat ccagctgtcg atcttgaggg aaatcgcacc attagtaaaa aaaggtggca 1470241 ctcttgtcta cagtacgtgt acaatggacc ggacagaaaa tgatgaagta atacatgcgt 1470301 ttatacaaga acatcctgat tttgaacccg atttgtctct tgaaaagcgg ctgcctgaaa 1470361 aggtgagacc ctttgttcgg gatggaaggc ttcaaatcct tcctcattat ttcggaacag 1470421 atggtttctt tatttgcagc atgagaaaga agggataagc aatggcagaa cttaataaaa 1470481 caaaagtaag aaaagaattg cggacagagc gtccgtctat ttattctttt gaattagatg 1470541 aaatcaaaca atggctgaca gacaatggag agaaaccgtt ccgtgcagcc cagatctttg 1470601 aatggctata tgaaaaacgc gtatcttctt ttgaagatat gacaaacctc tcaaaggatc 1470661 tgcgtgagaa attaaacact cgctttgtgt taacaacgct gaaaacggct gttaaacaaa 1470721 cctctcaaga cggtacgatg aagtttttgt ttgagcttca tgacggttat accatcgaaa 1470781 ccgttttaat gagacacgag tatggcaatt ctgtatgtgt aacgacacaa gtcggctgcc 1470841 gtattggctg cacattctgc gcgtcaacgc ttggaggctt aaaacgaaac cttgaagcag 1470901 gggaaattgt cgctcaagta gtcaaagtgc aaaaagctct tgatgaaacg gatgaacgcg 1470961 tcagctctgt cgtgatcatg ggaatcggcg aaccttttga taactttaac gaaatgctcg 1471021 ctttcttgaa aatcattaac catgacaagg gcctgaatat cggtgctcgc catattacgg 1471081 tctctacgag tggaatcatc ccgaaaattt acgaatttgc tgatcagcaa atgcagatta 1471141 actttgcaat ttctctgcac gcgccgaaca cagaaatcag aagccgtttg atgccgatta 1471201 acagagcata taaactgcct gatctaatgg aagccgttaa atattatatt aataaaacag 1471261 gacgccgtat cagctttgaa tacgggctgt tcggaggcgt aaacgaccag gtggaacacg 1471321 ccgaagagct tgccgacttg ctggaaggag tcaaatgcca cgtgaacttg attccggtaa 1471381 actacgtgcc tgaacgggac tatgtgcgca caccgcgtga tcagattttt gcttttgaaa 1471441 aaacgctgaa atcccgcgga gtaaatgtca caatccgaag agagcaagga catgacattg 1471501 acgcagcctg cggtcagctt cgcgcgaagg agcgtcaaga cgagacgagg tgatgagggt 1471561 tgttaacagc cttaaaaaca gatacaggaa aaatccgcca gcataatgaa gatgatgcgg 1471621 ggatattcaa ggggaaagat gaatttatat tagcggttgt cgctgatggc atgggcggcc 1471681 atcttgctgg agatgttgcg agcaagatgg ctgtgaaagc catgggggag aaatggaatg 1471741 aagcagagac gattccaact gcgccctcgg aatgtgaaaa atggctcatt gaacagattc 1471801 tatcggtaaa cagcaaaata tacgatcacg ctcaagccca cgaagaatgc caaggcatgg 1471861 ggacgacgat tgtatgtgca ctttttacgg ggaaaacggt ttctgttgcc catatcggag 1471921 acagcagatg ctatttgctt caggacgatg atttcgttca agtgacagaa gaccattcgc 1471981 ttgtaaatga actggttcgc actggagaga tttccagaga agacgctgaa catcatccgc 1472041 gaaaaaatgt gttgacgaag gcgcttggaa cagaccagtt agtcagtatt gacacccgtt 1472101 cctttgatat agaacccgga gacaaactgc ttctatgttc tgacggactg acaaataaag 1472161 tggaaggcac tgagttaaaa gacatcctgc aaagcgattc agctcctcag gaaaaagtaa 1472221 acctgcttgt ggacaaagcc aatcagaatg gcggagaaga caacattaca gcagttttgc 1472281 ttgagcttgc tttacaagtt gaagagggtg aagatcagtg ctaatcggca agcggatcag 1472341 cgggcgttac caaattctcc gcgtcatagg cggcggggga atggccaacg tgtatttagc 1472401 tgaggatatc attctagacc gtgaagtcgc aattaaaatc ctgcggtttg actatgcaaa 1472461 tgacaatgaa tttatcagac gtttccgcag agaagcccaa tccgcatcaa gcctcgatca 1472521 cccgaatatt gtcagcattt atgatttggg cgaggaagat gatatttatt atattgtcat 1472581 ggaatacgtt gaaggcatga cgcttaaaga atacataaca gcaaatgggc cgcttcaccc 1472641 taaagaagcg ctgaacatca tggagcaaat tgtctcagcc atcgctcatg cccatcaaaa 1472701 ccagattgtt cacagagaca tcaagccgca taacattttg attgatcata tgggaaatat 1472761 caaagtaacg gattttggaa ttgcgacggc actaagttcg accacaatca cccataccaa 1472821 ttcagttctg ggctcggtcc attacttatc acctgaacag gcccggggcg gcttagccac 1472881 aaaaaaatcg gatatttatg cgcttggaat cgttctattt gagcttttaa ccggccgtat 1472941 tccgtttgat ggagagtcag cagtcagcat cgccttgaag catcttcaag cggaaactcc 1473001 ttcggcaaaa aggtggaatc catcggtccc ccaaagcgtt gaaaacatca tactcaaggc 1473061 aactgccaaa gatccttttc atcgctacga aacggctgaa gacatggaag cagacataaa 1473121 aacagctttt gatgccgaca gactcaatga aaagagattt acgattcaag aagatgaaga 1473181 aatgacaaaa gcgataccta tcattaaaga tgaagaactt gctaaagctg ctggcgaaaa 1473241 agaagctgaa gtgacaaccg cacaagaaaa caaaacaaag aagaacggca aaagaaaaaa 1473301 gtggccgtgg gttttgctca cgatatgcct cgtttttatc acagctggaa ttcttgctgt 1473361 cactgttttt ccgtcgcttt tcatgcctaa ggatgtcaaa atacctgatg tctccggaat 1473421 ggaatacgaa aaagccgcag ggctcttgga aaaagaaggt ttacaggttg attccgaggt 1473481 gttggaaatc tcagatgaaa aaattgaaga gggcctgatg gtaaaaacgg atcctaaagc 1473541 ggataccaca gtcaaagaag gcgccacggt caccctttat aagagcaccg gaaaagcaaa 1473601 aacggagatc ggtgatgtga caggccaaac ggtcgaccaa gcaaaaaaag cgttgaagga 1473661 ccaagggttt aatcatgtaa cagtaaatga agtgaatgac gagaaaaatg cgggcactgt 1473721 cattgaccaa aatccttcag cagggactga gctggtcccg agtgaagatc aagtcaaact 1473781 tacagtcagt atcggacccg aagacattac gcttagagac ttgaaaacct acagtaaaga 1473841 agcagcgtct ggatatctgg aagacaacgg attgaagctt gtagaaaaag aagcatactc 1473901 agatgatgtt ccagaaggac aggttgtcaa acaaaaacca gcagcaggta cggcagtaaa 1473961 gccgggaaac gaagttgaag tgacattctc tctcggacca gagaaaaaac ctgcgaaaac 1474021 agtgaaagaa aaggtcaaga tcccctacga accagaaaat gaaggggacg agcttcaagt 1474081 gcaaatcgcg gttgacgatg cggatcacag catctctgac acttacgaag aatttaagat 1474141 aaaagagccg actgaacgaa cgatcgaact aaagattgaa ccaggccaaa aagggtacta 1474201 tcaagtaatg gtaaacaata aagttgtcag ctacaaaacc attgagtatc cgaaagatga 1474261 ataacaagga gggaaaatat gcctgagggc aaaattatta aggcgctaag cggcttttac 1474321 tatgtactgg atgaatcaga ggattcagat aaagtaatac aatgcagagg aagaggcatt 1474381 ttcagaaaaa acaaaattac ccctcttgtc ggtgattacg ttgtgtatca agctgaaaat 1474441 gacaaagaag gatatctaat ggaaattaaa gaaagaacca acgagcttat caggccgcca 1474501 atttgcaacg ttgatcaagc ggtccttgtt ttctcagcgg ttcagccttc tttcagcacg 1474561 gcattgctcg accgcttcct ggttctcgtt gaggccaatg atattcagcc gattatatgc 1474621 attactaaaa tggatctgat tgaagatcaa gatacagaag atacgataca agcctatgca 1474681 gaagactatc ggaatattgg ttatgacgta taccttacct cctctaagga ccaagatagt 1474741 ttagcggaca tcatcccgca ttttcaggat aaaacaacgg tatttgccgg tcagtccggt 1474801 gttgggaaat cctcgcttct caacgcgatc agtccggagc tcggattaag aacaaacgag 1474861 atttccgagc atttgggccg cgggaaacac acaacccgcc acgtggagct gattcacacg 1474921 tccggaggtt tggttgcaga tacaccggga ttcagctcgc ttgaatttac agacattgag 1474981 gaagaagagc tgggctatac cttccctgat atcagagaaa aaagctcttc atgcaaattt 1475041 agaggctgtt tacatctgaa agagccgaaa tgtgcggtga aacaagctgt tgaagacggg 1475101 gaattaaagc agtatcgcta tgaccattat gttgaattta tgacggagat taaagacaga 1475161 aagccgaggt attagcataa tgataaaggt tgcaccatct attctttccg ctgattttgc 1475221 cgctttaggc aatgagatta aagatgtaga aaaaggcgga gccgattgta ttcatattga 1475281 tgttatggac ggccattttg tcccgaatat cacaatcggt ccgctgattg tagaagcggt 1475341 ccggccggta acggatctgc cgcttgatgt ccatttaatg atagaagagc cggatcgtta 1475401 tatcccggct tttgcgaaag caggcgcaga tatcctgtct gtgcatgctg aggcatgtcc 1475461 gcacctgcac cgtaccatcc agctcattaa agagcaagga gtgaaggccg gagtagttct 1475521 aaacccgcat acccctgtac aagtcatcga acatgttttc gacgatcttg atcttgttct 1475581 tttaatgacg gtgaacccgg gcttcggcgg gcagaaattt attcattcag tccttcctaa 1475641 aataaaagag gttaagcgaa tggcggatga aaaaggaaaa aaagatctgt taattgaagt 1475701 agacggcggc gtcaacaaag aaaccgctcc gctcgtcatt gaagcgggcg caaatttact 1475761 cgttgccggt tcagctgttt atggccagtc tgaccgcaaa aaagcaattt ctgaaatcag 1475821 aggaagtaaa taagcagctt tagaaaagag ctgggcatac aatagcctaa gctctttttc 1475881 ctgtatgcag agaaaggaat cagagatgaa aacaattaat atcgttgcgg gaggcccgaa 1475941 aaatctcatt cccgatctaa ccggctatac ggatgaacac acgctttgga tcggtgttga 1476001 caaaggcacc gtcactctct tagatgccgg gatcattcct gttgaagcct tcggagattt 1476061 tgacagcata acggagcaag aacgccggcg aatagaaaaa gccgctcccg cccttcatgt 1476121 gtatcaagca gaaaaagatc aaacagattt agacctcgcc cttgattggg cgctggaaaa 1476181 gcagccggat attattcaga ttttcggcat tacaggcggc agagctgatc attttttagg 1476241 aaacattcag cttctgtata aaggtgtaaa aacgaacata aaaattaggc tgatagacaa 1476301 acaaaatcat attcaaatgt tccctcctgg tgaatatgat attgagaagg atgaaaataa 1476361 gcgatatatc tccttcatac cgttttccga agacatacat gagctgaccc tgaccggttt 1476421 taaatatcct ctaaataatt gtcatattac gctcggttca acactatgta ttagtaacga 1476481 actcattcat tcacgaggta ctttttcgtt tgcaaaaggc atattaataa tgataagaag 1476541 cacggattaa gcatgtgctt tcattcaatt gctgaaaaca atgaacaagg cggttacggg 1476601 acgttatagg aggggacaaa aatgaaattt tacaccatta aattgccgaa gtttttagga 1476661 ggaattgtcc gggcgatgct gggctcattt agaaaagatt aatgcccagg ggttcaaagc 1476721 cctctttcac cacataaaaa cgcctgccac atatcggggc aggcgttcat tttgttatac 1476781 acgctcaact ttaccggatt tcaaagctcg agcagataca tatacttttt taggttttcc 1476841 gttcacaagg atacgaacct tttgaagatt cgcgccccaa gtgcgcttag aagcgttcat 1476901 tgcgtgagaa cggttattcc cagctgttgt ttttttacct gtgataacgc atttacgtgc 1476961 catttgtttc cctcctcact tgcacaaaac atctactttt taacattcat ataatcttag 1477021 atgctttcga tatggatact ttaaataatt taccacagct aaaaaacgtt tgcaactatt 1477081 gtttcatcat ctttcaagaa aattcacttg acatcttgcg gaaacagcag cgctatagta 1477141 tatgtagagg tacggccagc gattattgcc tggtcttttc ataatggaaa ccatatagta 1477201 gaatagctgt aactctatgc attcgaagga ggaactagtg tgtccattga attaagaacg 1477261 aagtacggac agattgatat atctaatgaa gtcatcgcga tggttgcagg aggcgcggcg 1477321 gttgactgtt acggcattgt cggcatggcc tctaaaaacc agattaaaga cggactgact 1477381 gaaatccttc ggaaagagaa tttcagcagg ggtgtccaag ttcgccaaga aggagaacag 1477441 atacatatcg acatgtatat cattgtcagc tacggcacga aaatttctga agtggcacat 1477501 aatgtccaaa caaaagtaaa gtacacagta aatcaaacca tcggactggc agtggattct 1477561 gtcaatattt atgtccaagg cgtacgagtg acgaacccgt agttaggagg agtaggattg 1477621 tctatcagaa cattagacgg cagaaccttt gccgagatga ttcttgcggg agcgcagaat 1477681 ctgtctcaaa acgccagtgc agttgatgca ctgaacgtgt tcccggtgcc ggacggtgat 1477741 acgggaacaa atatgaacct gtcgatgact tccggagcaa gagaagttga acaaatggat 1477801 acggatgata tcgggaaggt gggctccgcg ttatctaaag ggctgctcat gggagcacgc 1477861 ggaaattcag gagttatcct atcccaattg ttccgcggat ttagcaaaaa cattgaaacg 1477921 aaaaaagaaa ttaatgcact tgagtttgcc gctgcgctgc aagcaggtgt agacatggcg 1477981 tataaagctg tcatgaaacc tgtagagggc accattttaa cagttgcaaa agacgctgca 1478041 aaaaaagcaa tgatcttagc agaaaaagaa accgatatca ctgcgctgat gactgcagtg 1478101 acagaagaag cagaggcgtc tttaaaccgc acccctgaat tgctacctgt cctaaaggaa 1478161 gtaggagttg tcgatagcgg gggcaaaggc ctgctctgtg tgtatgaagg tttccttgct 1478221 tcattaaaag gtgaaactgt acctcagaaa gcagttcttc cgtcacttga cgacatggtc 1478281 agcgcagagc atcacaagag cgcgcaaagc atgatgaata ccgaagatat tgaatttgga 1478341 ttctgtaccg aagtgatggt taggcttgat cagacaaaaa gagagttcga cgaaggcacg 1478401 ttcaggcaag acctcagcca gttcggagat tctctgcttg tgattgcgga tgaatcgctg 1478461 gcgaaggttc atattcatgc tgaagagccg ggaaacgtgt taaactacgc ccagcattac 1478521 ggtgaattga tcaaaataaa aatagaaaat atgagagaac agcatacctc tatcatcagt 1478581 caagaaagca aacctgcaga caacgaaaca ccgccggcaa aacagccgta tggcattgtg 1478641 actgtagcga tgggagaagg aattgcagac ctatttaaaa gcattggcgc ttctgttgtg 1478701 attgaaggcg gccagaccat gaacccaagc actgaggata ttgttgatgc cgtgaagtct 1478761 gtaaatgcag atacggtatt tatcctgcct aacaactcca acattatcat ggctgctaac 1478821 caagcggcca gcgtagtgga tgaacaggtt tttgtcattc ctgctaaaac ggttccgcaa 1478881 gggatgtcag ctctgctggc ttttaacccg gatcaagaag ctgaagcgaa cgaggccaat 1478941 atgctaagcg ccattcagca agtaaaaagc ggacaggtga cgttctcagt cagagatact 1479001 catattgacg gtaaagacat taaaaaaggc gactttatgg gcattctgaa tggaacgatt 1479061 atcggcactt ctgaaaatca gctgtcagcc gcgaaaatgc tgctgtcaga aatgatcgga 1479121 gaagatgatg aaatcgtgac cattctatat ggtgaggatg cgtctcagga agaagctgag 1479181 cagcttgaag cgtttctcag tgaaaagtac gaggagattg aggttgagat ccacaatggg 1479241 aaacagcctc tgtattcgta tatagtttca gcagaataga agggcaattt gcccttctat 1479301 tcttatgtct gcttttaagt gcggcagcgc tgtaacgcgc ccgcttgcca ttttatatct 1479361 gatcaattag tctagaagca aagcgctaat aagctctggt tcataaggag gaatagcatg 1479421 aaatacagaa gcgtttttga tattatcggc ccggttatga tcggtccgtc cagctctcat 1479481 acagcgggag ctgctagaat cgggagagtg gccagaagtt tatttggcag agagcctgag 1479541 cgcatcattg tatcttttta cggctcgttt gcggaaacgt ataagggcca cggcacagat 1479601 gtcgcgatta tcggcggatt gcttgatttt gatacattcg atgaacggat taaaaccgct 1479661 atacaaattg cagaagctaa aggaattgat atagagtttc gggtagaaga cgcagtcccg 1479721 gtccacccga acacagcaaa aatcaccatt tctgatgaaa agggtgagct ggaactgacg 1479781 ggtatttcga ttggcggagg aaagattgaa atcacagaat tgaatggttt tgagctccgg 1479841 ctgtcaggaa atcatccggc catattagtt gttcataatg acaagtttgg cacaattgcc 1479901 ggtgttgcca atgttctggc gaaattttca atcaacgtag gacatatgga agtagcccgg 1479961 aaagatatcg gccagcttgc gctgatgaca atagaggtcg atcaaaatat tgacgaccac 1480021 attctcgacg agctgtcgaa gctgccgaat attattcaag tgacaaagat tgctgactag 1480081 cgaaaagggt caggaggagc cagttatgtt tcgtaatgta aaagaattaa ttgagattac 1480141 taaagaaaaa caaatattga tctctgatgt gatgatagct caagagatgg aagtaacaga 1480201 aaaaacaaaa gaggacattt ttcagcagat ggatcataac ctgtctgtta tggaagcggc 1480261 ggttcagaaa ggactcgagg gagttacgag ccaaacgggc ttaacaggcg gagatgccgt 1480321 taaattgcag gcctatattc gatcaggaaa aagcctgtct ggcccgctga ttttagatgc 1480381 tgtatcgaaa gccgttgcaa caaatgaagt aaatgcagcc atgggaacca tctgtgcgac 1480441 accgactgca ggttctgccg gtgtggtgcc cggtacgtta tttgctgtaa aagaaaagct 1480501 gaatccaaca agagaacaaa tgatccgctt tttgtttaca gccggggctt tcggatttgt 1480561 cgtggccaat aacgcaagca tttccggcgc cgccggagga tgtcaggcag aggttggatc 1480621 agcttcaggc atggcggctg cggctattgt tgaaatggca ggaggaacac ccgaacaaag 1480681 cgcggaagcc atggccatta cattaaaaaa tatgctaggc ctcgtgtgcg accctgttgc 1480741 agggcttgtt gaggtgcctt gcgtgaaacg gaatgcgatg ggcgcgtcaa atgcgatgat 1480801 tgctgctgat atggcattgg cgggcattac aagccgtatt ccatgtgatg aggttatcga 1480861 tgccatgtat aaaataggcc aaacgatgcc aactgcactt agagaaacag gccagggcgg 1480921 tttagcggca acaccgacag gaagagaatt agagaaaaaa attttcggag gagcgctagg 1480981 ttcacgtgaa acaacatcag caaactagta tagctaacat taagggtatt gggccggaaa 1481041 cagaaaaaac attgaatgaa ctcggtattt atgacatttc tgatcttctg aattatttcc 1481101 cttatcgcta tgatgactac gagctgaggg atttagaaga agtaaagcat gatgaaagag 1481161 tcacagtcga agggaaggtt cattcagagc cttctcttac ctattacgga aaaaaacgaa 1481221 acaggctgac attcaggctt ctggtcggcc actatttaat cacagccgta tgttttaacc 1481281 ggccttattt gaagaagaag ctttcgctcg gctctgtggt gacggtttca ggtaaatggg 1481341 acaagcaccg ccaaaccatc tctgttcagg agttgaaaaa cgggccgcat caagaagaca 1481401 aaagcattga accagtgtat tctgtgaaag aaaatgttac cgtcaaaatg atgaggcgct 1481461 ttattcagca ggcgctgacc caatatgcag actcacttcc tgatcctctt ccggaaaagc 1481521 taagaaaaag ctataaactg cctgactatt atcaagcgtt aaaagcaatg caccagcctg 1481581 aaacaaggga agcattaaag cttgccagac ggcggtttgt ttatgaagaa tttttgttgt 1481641 ttcagttgaa aatgcaggcg ttccgaaagg cggaaagaga gcagacacaa gggatacggc 1481701 agcgtttttc aaacgaagaa ctcatgagat ttatcaaaag cctcccgttt cccctcacaa 1481761 acgcccagtc acgcgttctt cgcgaaataa cagcagacat gtcttctcca tacagaatga 1481821 accgtcttct tcaaggggac gttggatcag gaaaaacggc agtcgccgcc attgcactgt 1481881 atgccgcgat cctatccgga taccaaggag cgctcatggt gccgacagaa attctggccg 1481941 agcagcatgc tgattcgctc gtttcgctat ttgaaaaatg ggacgtcagc gttgctcttt 1482001 tgacaagctc tgttaaagga aagcggcgaa aagaactgct tgagcgtctt gcggcgggtg 1482061 agattgatat tcttgtagga acccatgctt taatccaaga cgaggtggag tttaaggcgt 1482121 tgagtctcgt tattactgat gaacagcaca gatttggagt tgagcagcgc aaaaagcttc 1482181 ggaacaaagg gcaggatccc gatgttctct ttatgacagc cactccaatc ccaagaacat 1482241 tagcgatcac agtattcggt gaaatggatg tatctgtcat tgatgagatg ccggctggac 1482301 gaaagcgaat tgaaacctat tgggtaaaac atgacatgct tgatcgtatt ttggcatttg 1482361 tcgaaaaaga attaaagcaa ggcaggcagg cttatatcat ctgtccgctg attgaagaat 1482421 cagataagct tgatgtgcaa aacgccattg acgtgtacaa tatgctttct gatatttttc 1482481 ggggaaaatg gaatgtcggc cttatgcatg gaaagctgca ttccgatgaa aaagatcagg 1482541 tcatgagaga attcagcgca aatcactgtc aaattctcgt atcaaccact gttgtggagg 1482601 ttggcgtaaa tgttccgaat gcaacaatta tggtgattta tgacgccgac cgtttcggac 1482661 tatcacagct tcaccagctg cgcggccgtg ttggacgggg tgagcatcaa tctttctgta 1482721 ttctgatggc tgatccaaaa tcagaaacag ggaaagaacg gatgaggatc atgtcggaga 1482781 ccaatgacgg tttcgagctg tctgaaaagg atctggaact gagaggtccc ggtgatttct 1482841 tcgggaaaaa acaaagcgga atgccggaat ttaaagtggc ggacatggtt catgattaca 1482901 gagcgcttga aacggcaagg caggatgctg cgaatcttgt ggcttctgac gcgttctgga 1482961 aggagccgga atacgctgtg ttaagagatg aattgctgaa gagcggagta atggacgggg 1483021 aaaaattaag ctgagtatca gaagtttttg gtgttcagcc agaaacaatc gttgcattcc 1483081 aatctatgaa attatatact actattagta cctagtctta attgtccgga tggtgtttag 1483141 atatgagaag aaataagaga gaacgccagg aattacttca gcagacgatt caagcaaccc 1483201 cctttattac agatgaagaa ctagcgggta aattcggggt gagcatccag acgatacgtt 1483261 tggaccgctt agagctttcc atacctgaac tgagagaaag aattaagaac gtggcagaga 1483321 aaacacttga ggacgaagtg aagtccctgt cacttgatga agttatcgga gaaattattg 1483381 accttgagct ggatgatcag gcgatatcca ttttagaaat aaaacaggag cacgtgttca 1483441 gccggaatca gattgcgaga ggacaccatt tatttgcaca ggcgaattct ttggccgttg 1483501 cagtcattga tgacgagctg gcgctgactg caagtgcaga catccgcttt acaagacagg 1483561 taaagcaggg tgaacgtgtc gtagcaaaag cgaaagtgac ggctgtcgaa aaagaaaaag 1483621 gaagaacggt tgtcgaagtg aacagctacg ttggcgaaga aattgttttt tctggacgct 1483681 ttgacatgta tcgttcaaaa cattcataaa ggtggagcat gcatgagaat agctgtagat 1483741 gcaatgggag gagaccacgc tcccaaagct gttattgacg gagttataaa aggtatagag 1483801 gcatttgatg atctccatat cacacttgtc ggtgacaaaa caacgataga atcacattta 1483861 acaactacat cagatcgcat cacggtgctg cacgcagatg aagtgattga gcctacggat 1483921 gaaccggtcc gtgccgtgcg aagaaaaaag aactcatcta tggttcttat ggcgcaggag 1483981 gttgcggaaa acagagctga cgcctgcatt tcagcgggaa ataccggtgc attaatgaca 1484041 gccggtctct ttattgtcgg gagaattaaa ggaattgacc gtccggcgct tgctccgaca 1484101 cttccgactg tttcgggaga cggatttctt ctccttgatg tcggcgccaa tgtcgatgcc 1484161 aaaccggagc acctcgttca atatgccatc atgggttctg tttattctca gcaagtgcgc 1484221 ggtgtcactt caccgagagt cggactttta aatgtcggaa cagaagataa aaaaggaaac 1484281 gaactgacga agcagacgtt tcaaatttta aaagaaacag caaacatcaa ttttatcgga 1484341 aacgtggaag cgcgagacct tttagatgat gtggcggatg ttgtagtaac agacggcttt 1484401 accgggaatg ttacactcaa aacgctggaa ggctctgcgt tgtcaatttt taaaatgatg 1484461 agagacgtaa tgacgtctac tttgacatcc aagcttgcag cagctgtgct gaaaccaaaa 1484521 ttgaaagaaa tgaaaatgaa aatggagtat tcgaattatg gcggagcaag tctttttggc 1484581 ttaaaagcgc ctgtgatcaa ggcgcacggc tcttcagatt caaatgctgt attccatgcg 1484641 attcggcaag caagagagat ggtcagccaa aatgtggctg cgctcattca ggaagaagtg 1484701 aaagaagaaa aaacagatga gtagtctgga ggtttttaca tcatgagtaa gattgcattt 1484761 ttattcccgg gtcagggatc acaatttatc ggcatgggaa aagagcttta tgagcaggtg 1484821 cctgctgcaa agcgtctgtt tgatgaagcc gatgaaacgt tggaaacaaa actcagctcg 1484881 cttatttttg agggggatgc tgaagaatta acacttacat acaatgcgca gcctgctttg 1484941 cttacgacaa gcatcgctgt tcttgagaaa tttaaagaat ctggcattac acctgatttc 1485001 acagcaggac acagccttgg tgaatattct gcactggttg cggctggcgc tctgtctttc 1485061 aaagatgctg tttatactgt cagaaagcgc ggagagttta tgaatgaagc ggtgccggct 1485121 ggcgaaggag caatggctgc gattctcggc atggatgctg aagcattaaa gcaagtaacc 1485181 gataaagtca cagaggaagg caaccttgta cagcttgcga atctcaactg tcctggccaa 1485241 atcgtcattt ccggaacagc taaaggggtt gagcttgcat ctgaactggc aaaagagaac 1485301 ggcgcaaaac gcgcaattcc gcttgaagta agcggtccgt tccattctga actgatgaaa 1485361 ccggctgctg aaaagctgaa agaggtattg gacgcctgtg acataaaaga cgctgacgtt 1485421 ccggtcatct caaatgtttc tgctgacgtg atgactgaaa aagcagatat caaagaaaaa 1485481 cttattgagc agctttactc tccggttcgt tttgaggaaa gcattaacaa gctgatcgca 1485541 gagggtgtta cgacttttat tgaaatcggt cccggaaaag tgctttcagg ccttgtgaaa 1485601 aaagtgaata gacggttaaa aacaattgct gtatcagatc cggaaacgat cgagctggca 1485661 attcaaacgc ttaaggagga gaatgataat gcttaatgat aaaacggcta ttgtcactgg 1485721 cgcatcccgc ggaatcggcc gctcaatcgc ccttgatctg gcaaaaagcg gagcaaatgt 1485781 tgtcgtgaac tactccggca atgaagcgaa agcaaatgaa gtggtagatg aaatcaaatc 1485841 aatgggcaga aaagcaattg ctgtaaaagc ggatgtatca aatcccgaag atgtacaaaa 1485901 catgataaaa gaaacattgt ctgttttttc tacgattgac attctggtta ataatgcggg 1485961 aattacaaga gacaatctca tcatgagaat gaaagaagac gaatgggatg acgtcattaa 1486021 cattaacctg aagggtgttt tcaactgcac aaaagctgtt acaagacaaa tgatgaaaca 1486081 gcgttcaggc cgcattatta acgtatcgtc tatcgtcggc gtcagcggaa accctggaca 1486141 agccaactac gtggctgcaa aagccggcgt catcggttta accaaatctt ctgctaaaga 1486201 gctcgccagc cgaaatatta cggtaaacgc aatagcgcca ggatttatct caactgatat 1486261 gacagataaa cttgcaaaag acgttcaaga cgaaatgctg aaacaaattc cgctcgcgcg 1486321 ctttggtgaa cctagcgatg tcagcagtgt tgtcacgttc ctagcttcag agggagctcg 1486381 ttatatgaca ggccaaacgc ttcatattga cggcggaatg gtgatgtaag ttttttctcg 1486441 aaaatttcat cgtagtttct ctagtttttt aaaaacgaat ccactataat acttgagggg 1486501 aggtgaattg ctatggcaga cacattagag cgtgtaacga aaatcatcgt agatcgcctt 1486561 ggcgttgatg aagcagacgt caaacttgaa gcttctttca aggaagactt aggtgctgat 1486621 tccctagatg tagttgagct tgttatggaa cttgaagacg agtttgatat ggagatttct 1486681 gacgaagatg ctgaaaagat tgcaacagtc ggcgacgctg tgaactacat acaaaaccag 1486741 caataagctg atgctaaaag tcccgccgaa acgcggggct ttagcccttt attcgtgcag 1486801 ttattacagc atgccgcttt tacgcgcgct gtatccggtt tagtcagaga agcgcggtga 1486861 acctgatgtg cctatggagg ttactatgtc aaaacactca cattataaag ataaaaaaaa 1486921 gttctataaa aaagtagaac aatttaaaga gtttcaagaa cggatttcgg ttcactttca 1486981 aaatgaaaag cttttgtatc aagcatttac acattcatct tatgtgaatg agcatcggaa 1487041 aaagccgtat gaagataatg aaaggcttga atttttaggt gacgctgttt tggaactgac 1487101 gatctccaga ttcttatttg ccaaataccc ggctatgagt gaaggagatt tgacgaaatt 1487161 gagagccgca attgtttgcg aaccgtctct cgtttcattg gctcacgagc tgtcattcgg 1487221 cgatcttgtc ctgttgggta aaggcgagga aatgacaggc ggaagaaagc gtcctgctct 1487281 attggcggat gtttttgagg catttatcgg agccttgtac cttgaccaag gattagagcc 1487341 ggtcgaaagt ttcttaaaag tttatgtgtt ccctaaaatt aacgatggtg ctttttctca 1487401 tgtgatggat ttcaaaagcc agctgcagga atacgtgcag cgggacggca aaggctctct 1487461 ggagtataaa atctccaacg aaaaaggacc tgcgcacaac cgtgaatttg aagccatcgt 1487521 atctctaaaa ggtgaaccac tcggagtcgg aaacggccgt tcaaagaaag aagccgaaca 1487581 gcacgctgct caggaagctt tagctaaatt gcaaaaacac catacgaaac aataaaatcc 1487641 cccttatgac tcagggggat ttcagtatgt atgccgtctt atttgaccaa tgtttatgat 1487701 agaattgaaa tacttattac ataaggagga tcgctatgtt cctcaaacgt ttagacgtta 1487761 taggatttaa atcatttgca gaacggattt ccgtagactt cgttaaaggc gtgacagcag 1487821 ttgtcgggcc gaacggaagc ggaaaaagca acatcacgga tgccattcgc tgggttctcg 1487881 gcgaacaatc ggcacgctct cttcgcggcg gaaaaatgga agacatcatt tttgctggga 1487941 gtgattcaag aaagcgatta aatctagctg aagttacgct tactcttgat aatgatgatc 1488001 atttcttgcc aattgacttc cacgaggtga gtgtcacaag acgtgtgtac agatcaggtg 1488061 agagtgagtt tctgattaac aatcagccat gccgcttgaa agatattatt gatttattta 1488121 tggactctgg gcttggtaaa gaagcatttt ctattatcag ccaagggaaa gtggaagaga 1488181 tcctgagcag caaagcggag gatcgccgca gtatctttga agaagcggcc ggggtgctta 1488241 aatataaaac gagaaagaaa aaagcagaaa ataaactgtt tgagacacag gacaatctaa 1488301 atcgggtaga agatatatta catgagcttg aaggacaggt tgaacctctt aaaattcaag 1488361 cttcaatagc gaaagactac cttgagaaaa agaaagagct ggagcatgtt gaaattgcgc 1488421 tgactgccta tgatatcgaa gagctgcatg gtaaatggtc gactcttaaa gagaaagtgc 1488481 agatggcaaa agaagaagag cttgctgaat cgtctgctat ttctgcgaaa gaagcaaaga 1488541 ttgaggatac aagggacaaa atacaagcgc ttgatgagtc agtagatgag ctccagcaag 1488601 ttttactggt aactagtgaa gagctggaaa agcttgaagg ccgtaaagaa gtcctgaaag 1488661 aacgaaagaa aaacgctgtg caaaaccaag aacagcttga agaagccatc gttcagttcc 1488721 agcaaaaaga aacggttctg aaagaagagc tttcgaagca ggaagctgtc ttcgaaacgc 1488781 ttcaggctga ggtgaagcag ttaagggcgc aagtaaaaga aaaacagcag gctctcagtc 1488841 ttcacaatga aaatgtcgaa gagaaaatcg agcagctgaa aagtgattat tttgagctgt 1488901 taaacagcca ggcttcgata cgcaacgaac tccagcttct tgatgaccag atgtcccaat 1488961 ccgctgtcac attgcagaga cttgcggaca acaatgaaaa gcacctgcag gaacggcatg 1489021 atatttctgc gcgtaaagcc gcatgtgaaa cggaatttgc ccgaattgag caggagattc 1489081 acagtcaagt cggtgcatat cgtgatatgc agacaaaata tgagcagaaa aagcgccaat 1489141 acgaaaaaaa tgaatccgct ctgtatcagg cataccaata cgttcagcaa gcgagatcaa 1489201 aaaaggacat gcttgagacg atgcagggag atttctccgg cttttatcaa ggtgttaaag 1489261 aagtgctgaa agcgaaagag cgccttggcg gaattcgcgg agcggttctt gagctgattt 1489321 ctacagaaca gaagtatgaa acggccattg aaatagcgct cggcgcttct gctcaacacg 1489381 tcgtgaccga cgatgaacaa tctgcccgca aagcgattca atatttaaag cagaattcct 1489441 tcggccgggc gacgtttctg cctctttctg ttattagaga ccgccagctt caaagccgtg 1489501 acgcggaaac agccgcccgg cattcatcat ttctcggggt tgccagtgaa cttgtcacat 1489561 ttgatcctgc gtatcgaagc gtcatccaga atcttcttgg aaccgttctg atcacagagg 1489621 acttaaaggg tgcaaacgag cttgcgaagc ttctcgggca ccggtaccgc atcgtaaccc 1489681 ttgagggaga tgttgtgaac cccggtggtt caatgacggg cggcgcggtt aaaaagaaaa 1489741 ataactccct ccttggaaga agccgggagc tagaagatgt gacgaaacgg ctcgctgaaa 1489801 tggaagagaa aacggcactg cttgaacaag aggtcaaaac ccttaagcac tccattcagg 1489861 atatggagaa aaaactggct gacttaagag aaaccgggga aggcttaagg ttaaagcagc 1489921 aggatgtgaa aggccagctg tacgaacttc aagttgccga gaaaaatatc aatacccatt 1489981 tagagctcta tgatcaagaa aaatctgctc tgtcagaaag cgatgaagag agaaaagtgc 1490041 gcaaacgcaa gcttgaagaa gagctctctg ccgtatctga aaagatgaaa cagcttgaag 1490101 aggacataga cagactgaca aaacaaaaac aaacgcaatc ctcaacgaaa gagtctctct 1490161 ccaacgagct gactgagctg aagatcgcag cggccaaaaa agagcaggct tgcaaggggg 1490221 aagaggacaa ccttgccaga ttaaagaaag agctcactga aacagagctt gcgttaaaag 1490281 aagcaaaaga agacttaagc ttcttaacgt cagagatgtc atctagcacc agcggcgaag 1490341 aaaagctgga agaagcagca aaacataaat tgaatgacaa aacgaaaacg atcgaactga 1490401 ttgcattaag gcgcgatcag cgcatcaagc ttcagcatgg gcttgatacg tatgagcgtg 1490461 agctgaaaga aatgaaacgc ctgtataaac aaaaaacaac gctcttaaaa gacgaagaag 1490521 tcaaacttgg acgaatggaa gtcgagcttg ataatttact ccaatactta cgggaggaat 1490581 acagcttgtc ctttgagggg gcaaaagaga aatatcagct tgaaactgat ccagaggaag 1490641 ccagaaagcg cgtgaagctg attaaactcg caattgaaga gctgggtacc gtgaacctcg 1490701 gaagcataga tgagtttgag agggtcaacg aacggtacaa gtttctgtcg gaacaaaaag 1490761 aagatttaac agaagcgaaa aataccttgt tccaagtgat tgaagaaatg gatgaagaaa 1490821 tgacgaagcg ctttaacgac acattcgtcc aaatccgctc acactttgat caagttttcc 1490881 gctccttatt cggaggaggg cgagctgaac tgaggctcac cgatcctaac gatctgcttc 1490941 attcaggagt cgagattatc gctcagccgc cggggaaaaa gctgcaaaac ttaaacctcc 1491001 tgtcaggcgg agagcgtgcg cttactgcta tagcgctctt attctcaatc ctaaaggttc 1491061 gtccagtgcc gttttgcgtc cttgacgaag tagaggctgc gctcgacgaa gcgaatgtgt 1491121 tccgatttgc gcagtattta aaaaaataca gcagcgatac tcagtttatt gtgattaccc 1491181 acagaaaagg aacgatggag gaagcggatg tgctttatgg cgtaaccatg caggaatccg 1491241 gtgtttccaa ggtaatttca gttaagctgg aagaaacaaa agaattcgtt cagtaacgag 1491301 gaaagaggtt aaaagatgag cttttttaaa aaattaaaag agaaaatcac aaaacagaca 1491361 gattccgtat ctgaaaagtt taaggatggc cttgaaaaaa caagaaactc ctttcaaaac 1491421 aaagtgaatg atcttgtatc ccgttaccgt aaagtggatg aggatttctt cgaagagctt 1491481 gaagaggttc ttatcagcgc ggatgtcggt tttacaaccg ttatggaatt aatagatgag 1491541 ctgaaaaaag aagtcaaacg cagaaatatt caagatccaa aggaagtcca gtcagtgatt 1491601 tctgagaaac tggtcgagat ttataacagc ggagatgagc aaatttcaga actgaacatc 1491661 caggatgggc gtttaaacgt aatccttctg gtaggtgtaa acggcgtcgg gaaaacaaca 1491721 acgatcggaa agcttgctca taaaatgaaa caagaaggaa aatctgttgt acttgccgcc 1491781 ggagacactt ttagagcggg agccattgaa cagctggaag tatggggaga gcgtacagga 1491841 gtgcctgtca ttaagcagac ggcaggaagc gatccggcgg ctgtcatcta cgatgctgtt 1491901 catgctgcga aagcaagaaa tgccgatgta ttaatttgtg atacggcagg gcgtctccaa 1491961 aacaaagtaa atctcatgaa agagcttgaa aaagtaaaac gtgttatcga aagagaagtt 1492021 cctgaagctc cgcatgaggt gctgcttgcc cttgatgcca cgaccggcca aaatgcaatg 1492081 gctcaggcaa aagaattctc taaagcaaca aatgttaccg gcattgcttt aacgaagctt 1492141 gacggtacgg caaaaggcgg tatcgtcctt gcgattcgca acgagcttca catcccggtt 1492201 aaactagtcg gtttaggaga aaaagttgat gaccttcagg aatttgatcc agaatcctat 1492261 gtgtacggac tcttttcaga tttagtggaa aaagccgacg attaagaaaa aggccccaac 1492321 atcttggggc ctttttcttt tttatcttct tacttgatag gcgaaatgat aaaggctgtt 1492381 atcagtggat accagtcttg actcaccaga aaaaactctg aatgggatga tgtcatagta 1492441 atgaacggaa acagatgtgt aatacgtata gtaaccagca gctggcccca aatacattgg 1492501 aacctcaaat gttccgtttg catcagtcgt tcctgaagca gtttgtgttg tgtttccgac 1492561 cttcgtgtcc gcttcaaatc ttacgggcgc gtttggcact ggctgtccgt tttggtcgag 1492621 taatttgccg cttactgtaa tattgtactt gactcgccaa tattgacctt gtccgtaatt 1492681 gattttaccg tatacccctc catctgtgct gatatttgtg attgaggcct tataaggtgc 1492741 ctcagcagcg tctgcttgct gtgccgggaa acctattgta aacagggctg ccagacataa 1492801 cataaacaat aaaccgattt ttttcataaa aatcctcctt aaaatagggt tcatatacaa 1492861 tatcggaata aattggatga tatttagcgt attttggaaa agttaatcgc cgctttgaca 1492921 agataaaaac ttgacagtgt cattaaaacc gtgtaaacta agttatcgta aagggatttg 1492981 acttaacaaa ggggagagct caaatgtcac tcgaaaagac aacgagaatg aattatctgt 1493041 ttgattttta tcagtcgttg ttgacgtcaa aacagaagag ctatatgtcg ctttattatt 1493101 tggacgattt ctccctaggc gaaatagccg aagaatatga ggtttcaaga caagctgttt 1493161 atgataacat caaacgaaca gaagcaatgc ttgaacaata tgaagaaaag ctgctccttt 1493221 tgaaaaagtt tcaggagcgt aaagagatgt ttaataagct gaaggagctt gcttccggtt 1493281 caaaagaaga ggaagaaatt acagctctga ttgaagcgct tgagaaatta gattaggagg 1493341 cggcaaacta tggcatttga aggattagcc gaccgactgc agcagacgat ttctaaaatc 1493401 cgcggaaaag ggaaagtcag cgaacaagat gtaaaagaga tgatgcgtga ggtccgtctt 1493461 gcgctgcttg aggctgacgt taactttaaa gtagtcaagg attttgtcaa aaaagtaagt 1493521 gaacgcgctg taggccaaga cgtcatgaaa agtctgacgc ccggccagca ggtcattaaa 1493581 gttgttcaag aggaactgac tgagctgatg ggcggcgaag agagcaaaat cgccgtcgca 1493641 aaaaggccgc cgactgttat tatgatggtc ggtctccaag gtgccggtaa aacgacaaca 1493701 agcggtaagc ttgcgaatct gctgcgcaaa aagcataatc gcaaaccgat gctggttgct 1493761 gccgatattt accgcccagc cgcaattaag cagctggaaa cactcggcaa acagcttgat 1493821 atgcctgttt tctctcttgg cgatcaggtc agtcctgtag aaatagctaa acaggctatt 1493881 gagaaagcca aggaagaaca ttatgactac gtcattttgg atacggcagg gcgcttgcat 1493941 atcgaccatg aactgatgga tgaactgacc aacgtcaaag aaatcgcgaa tccggaagaa 1494001 attttcctgg ttgtcgattc aatgaccggt caggacgctg tgaatgttgc caaaagcttt 1494061 aatgaacagc tcggtttaac cggtgttgtg ttgactaagc tggatggaga cacacgcggc 1494121 ggggctgcgc tttctattcg cgctgtcaca aacacgccaa ttaagtttgc aggtttgggc 1494181 gaaaagcttg atgcgttaga gccgttccat cctgaacgca tggcatcaag gattctcggc 1494241 atgggcgacg tgctgacatt gattgaaaaa gcacaggcca gcgttgatga agacaaagcc 1494301 aaagagctgg aacaaaaaat gagaacgatg agcttcacat tggacgattt tctggagcag 1494361 ctcgggcaag tcagaaacat ggggccgctt gatgagcttc tgcaaatgat gccgggtgca 1494421 ggtaaaatga agggcctgaa aaacatccaa gttgatgaaa aacagctgaa tcatgtggaa 1494481 gcaatcatca aatcaatgac tgttcttgaa aaagaacagc cggatattat caatgccagc 1494541 cggcggaagc ggattgcaaa aggaagcggg acatccgtac aggaagtcaa ccgtctgctt 1494601 aagcagtttg atgaaatgaa aaaaatgatg aagcagatga caaacatgtc aaaaggcaag 1494661 aaaaaagggt ttaagctacc ttttatgtaa tcggttatac atgataaaac cgttgttaag 1494721 aaaaaacact ttacaaacac ttttatcatt gttaatatac tatcttgttg aaatattttc 1494781 ggaggtgcta gtaaaatggc agtaaaaatt cgtttaaaac gtatgggagc aaaaaaatct 1494841 cctttctatc gtattgttgt agcagattct cgttcaccac gtgacggccg tttcatcgaa 1494901 acagtcggaa cttacaaccc ggttgcaaaa ccagcggaag taaaaattga cgaagagctt 1494961 gctcttaaat ggcttcaaac tggagcgaaa ccatctgata cagttcgcaa cttgttctct 1495021 agccaaggaa tcatggaaaa attccacaac gctaaacaag gcaagtaatg actgatcaac 1495081 acttggaaga tttgattgtc cacattgtga cgccgcttgt tgatcatcca gatgacattc 1495141 gcgtcataag agaagaaacc gatcaaaaga ttgcgctgcg cttatctgtc cataagtcag 1495201 ataccggtaa agttatcgga aagcaaggcc ggactgcaaa agcgattcga acagctgtat 1495261 ttgcagctgg cgtacagtct tctaagaaag ttcaatttga aatatttgac taaaagggag 1495321 agggccggca cctccccttt ttttacacgc aaaaaaaggg taaactgata gaagcttagg 1495381 caaaatagaa aagcctggac gagtaaaagt tttaaaagcg gggagcttgg tgcgatgcaa 1495441 attattcacc gtgtagccgt tatgcaagtc ttaaccgagc gcagtaaaga aaagctttta 1495501 gcttcttttg ctgagaagaa acaaatgctt gaacgagaat gcagccagct ctattttcag 1495561 cttagaaaac atgagaaaga acagcaaaac cctaatatga ttgaacaatt taaaaaggca 1495621 atagaaaagc gaaaagatga tataaaaatc attgattttc aaattgctca agtacataca 1495681 ttgccgcttg gcagtgagtt gaaagaaaag gaagtcgatg cgctgctgac gattgaagcc 1495741 ggggatgact ggcatgagaa aacagcagcg aacaccatcg tcataaaaga cggaaaagta 1495801 attgaaattc gccagaggtg atcatatgac aaagcgatgg tttaatgtag gcaaaatcgt 1495861 aaatacccac ggaatcaaag gcgaagtgcg ggtgatttca aaaacagatt ttgccgaaga 1495921 acgatacaag ccgggaaaca cgctgtattt gtttatggac ggccgtaacg aaccagtgga 1495981 ggtaacggta aacacacata gactgcataa gcaatttcat ctcctgcagt ttaaagaaag 1496041 acaaaaccta aatgaagtag aagagctgaa aaacgcaatc attaaagttc ctgaagaaga 1496101 attaggagag ctgaatgagg gtgaatttta tttccacgaa attattgggt gtgaagtatt 1496161 tactgaagaa ggcgaactca tcggaaaggt caaagaaatt ttgacgcctg gagccaatga 1496221 cgtttgggtc atcggacgaa aaggaaaaaa agacgcactc attccttaca ttgaatcagt 1496281 ggttaaacat atcgatgtca gggaaaagaa aattgagatt gaactcatgg aagggttaat 1496341 agacgaatga aaatcgattt tttgacgctg tttcccgaaa tgtttgaagg cgtgctcggc 1496401 tcatcgattc ttcaaaaagc ccaggaaaaa gatgcggtgc agtttcaagt cgtaaatttc 1496461 cgagagtact ctgataacaa gcacaatact gttgatgatt atccttatgg cggcggggca 1496521 ggcatggttc tcaagcccca gcctgttttt gacgcggtcg aggacctgac atcaaaggca 1496581 gccgctgctc cgcgtattat cctcgtatgc ccgcaaggtg agcgttttac ccaaaaaaaa 1496641 gccgaacaat tagctaagga agagcatttg ctgttcattt gcggccacta tgaaggctat 1496701 gatgaacgca ttcgcgagca cttggtaacg gatgaaatat caattggcga ctttgttctg 1496761 acgggcggtg agctccctgc aatgatgatc gcagacagtg tggtcagact gcttccgggt 1496821 gtactgggta aagaggcttc ccatattgag gattccttca gcaccggact tttagagcac 1496881 ccgcattata caagaccggc agattacaaa ggtttaaaag tgcctgaaac actcttgtca 1496941 ggaaaccatg caaaaattga agaatggcgg aataaagaat cgatcagaag gacctaccta 1497001 agacgtccgg atctgttgaa agaccacccg cttacagagc agcaaagaaa gtggatttct 1497061 gaatgggaaa aagaatagat tttattgcat aggctatgaa attgtgataa gatactactt 1497121 gtggcttaag cgggcttatc cgctgcaagc ttgaaaacga tgttccgctg tgccggtttt 1497181 tgtggccaag agcatctgtt ggaaggagtt gaaaacgatg caaaaactaa ttgaagatat 1497241 cacaaaagaa cagcttcgta ctgatcttcc tgcgttccgt cctggtgaca ctttacgtgt 1497301 acacgttaaa gttgttgagg gtaaccgtga gcgtatccag atctttgaag gtgttgtgat 1497361 taagcgtcgt ggtggtggaa tcagcgaaac gttcacagtt cgtaagattt cttacggtgt 1497421 tggcgttgaa cgtactttcc cagtacacac accaaaaatc gcgaaaatcg aagttgtacg 1497481 ttacggtaaa gtacgccgtg ctaaacttta ctacctgcgt gaacttcgcg gaaaagcggc 1497541 tcgtattaaa gagatcagac gataatgata acgaacgaaa agagcttgtt acctgtaaca 1497601 agctcttttt ttatacagaa tttgaaaatg ccggacaggc atcgtaaaat acataaagga 1497661 caacaatgaa tcatgcatac tgaagataaa ggcggtgttc gtgtcacatg acaattcaat 1497721 ggttcccggg ccatatggca aaagcaagaa gggaagtaac cgaaaaatta aaattaatcg 1497781 atatcgtata tgaattggta gatgccagaa ttccaatgtc atcaagaaac ccaatgattg 1497841 aagatattct aaaaaacaag ccgcgaatta tgctgttaaa caaggctgac aaagcagatg 1497901 cggcagttac acagcagtgg aaagagcact ttgagaacca ggggatccgc tctctgtcta 1497961 ttaattctgt aaatggacaa gggttaaatc aaattgtgcc tgcatcaaaa gagatcctcc 1498021 aagaaaaatt tgaccggatg cgtgcgaaag gtgtgaagcc gagagcgatt cgcgctttga 1498081 ttatcggcat tccaaacgtc ggaaaatcaa cgctcatcaa ccggcttgca aagaaaaaca 1498141 tagcaaaaac gggagacaga cctggtatta cgacttctca acagtgggtc aaagttggga 1498201 aagaattaga gctattagat acaccgggaa ttttgtggcc taaatttgag gatgagcttg 1498261 tcggtttgag actggcagtc accggggcta ttaaagactc gattatcaat ttgcaggacg 1498321 tggccgtgtt tggtcttcgt tttctcgaag aacattaccc agaacggctt aaagagcgtt 1498381 atggccttga tgagatccca gaggacattg ccgagctgtt tgatgcaata ggtgaaaagc 1498441 ggggctgtct catgagcggt gggctcatca actacgataa gacgactgaa gtcatcattc 1498501 gcgatattcg cactgaaaag ttcggcaggc tgtcatttga acagccgacg atgtaaaggc 1498561 gcgcagaaat gcgggtcttt attttttctt ggctgaaccg atacatacag taagggagaa 1498621 gagaaagtga atacattaac cgtaaaggac attaaagacc gtttgcagga agtgaaggat 1498681 gcacaagacc catttattgc ccaatgcgaa aacgacccga gaaaaagcgt tcaaacgctt 1498741 gtagagcaat ggcttaaaaa gcaagcgaaa gaaaaagcgc tgaaagaaca atgggtgaat 1498801 atgacttcct atgaaaggct ggcaagaaac aaaggatttc gcttgattgc aggtgttgac 1498861 gaggtcggcc gggggccatt ggcaggacca gttgtcgcca gcgcagtcat ccttccagag 1498921 gaatgtgaaa tacttgggct gacagactcc aaaaagcttt cagagaaaaa acgcgaggaa 1498981 tattacgagc ttattatgaa ggaagcactg gcggtcggga taggaattgt agaagctact 1499041 gtgattgatg agatcaatat atatgaagct tcaaaaatgg caatggtgaa agcgatacag 1499101 gatttgtcgg atacacctga ttatttgctt gttgacgcaa tgacacttcc gctcgacacg 1499161 gctcaggcgt caattataaa aggcgatgcc aaaagcgtgt ctattgcggc aggtgcgtgt 1499221 atcgcaaaag tgacgaggga ccgaatgatg agcgcttatg ccgaaacgta tcccatgtac 1499281 ggctttgaaa aaaataaagg ctatgggaca aaagaacatt tggaagctct cgctgcatac 1499341 ggcccaactg aattgcaccg caaaactttc gctcctgttc aatctttcag ataaatcacc 1499401 atggacaagg aggcaccttt ttaaaatgaa catacgaaat gatgtgcaaa aggcgctgca 1499461 gcaccttttc gggcgtacag ccgtcccgca ggaaacatca aaagtaaacg aagcgctaaa 1499521 cggggagaag cgtctcctct taggaaaagt gcttcgttta ctaggagatc agcatgccct 1499581 gatccaagtc ggcaatcaaa ctgttcaggg aaaacttgaa actcagcttc gtcctcaggc 1499641 atactattgg ttttcctacg aaaaaaaaac ggcagagcaa acaggccgtc ttcaggtcgt 1499701 tcaaagcttt gatcaaaatc ctaaaaccat tcaggatgca gctggcaaac ttttaaatgc 1499761 tatttcagtg aagacgtcaa acgcagctct catgatgaca ggagcgatgc tgaaaagcaa 1499821 aacacccgta acagaaaatg atatcaaaac agctgtccgc tggatggaca cgctgccttc 1499881 gcaagacaca aaaaaagcag ttgaaacggt tctcttcgct ttaaagcgtg atcttcccat 1499941 tcactccgag attttgaatg gtgttcacgc tgtgaaatcg cctgttccgt tgcatcagca 1500001 cgtatcccag ctgctacagg caatcgacca aaaccctcag cagagccaaa tgatgtcaaa 1500061 gctaaaggaa gcagtcacgg tgcttttaaa tagtgaaatc gatgtccatg cagaacggct 1500121 gattgataag cttatttctt taaccgacaa tacgaaagca ccttctccga cgaatacagc 1500181 tggaagcagg gagcttagca caccagctgg ctcccccgga aaagccagcc tgccgattgc 1500241 aaatcacaca gcagaacagg gaagcataca agaagagcct gttaaaacag cagcagacat 1500301 tccaattaaa gaagcccgcc agctgctggt gaagctgacg gaatctgctg aaaaaaacag 1500361 tctccaaatt gtgaaagaag cagcaaattg gattaaagcg gctgcttcat cgggtgatag 1500421 taagtcactt gcagcttcag ctgttttaca ggcggcacaa gtcacagatc aggaagccga 1500481 agtcttttta aaggctgttc agcagacagc accccatttg gcggataagg cagatgttct 1500541 ttctttctta tccaaagtga aaacggcaat cggcgcaagg gacgaggttg cgttcattaa 1500601 agcgtttgaa caaggaagcg cagtcacatc tggcgaaatg caatccatca agctggctct 1500661 ttctgcctta agagcatcgc atgaggtagc cgaaccagtc aaacaagaag ccgatcagct 1500721 ttttcataaa ttaaatggcc agcttttcat gcagcaggac catccatcat acagccaaat 1500781 tgtaatgtca tttccgatgt tttcgaagtc aggggttcag gacatgactg ttctgtttaa 1500841 aggaaagaaa gaagcggatg gaaagcttga tccttcccat tgccgccttt tgtttttgct 1500901 gcagcttgat acactaaaag aaaccgtcgt tgattgcttg gtacagcaaa aagtcatgac 1500961 cattacaata gagactgatt tcgagctgca ggctgcgatc gatccgatgg tgcccgcgct 1501021 taaacagggg ctaaaggaaa tggggtacag cctttcaggg gtaaacgcta aaaaaagggt 1501081 tcacaccgaa gaaaaggctt caatcgatca atatataaca agtatcagtg atcaggaagt 1501141 ggatgtgaaa atatgaaaga gcagacaccg atcagaaaag ctgttgctct ccattatgac 1501201 gaacaaaaag acaaggcgcc gagagtgatt gccacaggga agggccatgt agctgacaac 1501261 attataaaag aagcgaaaaa agcaggggtc ccgattcaag aagatcggac ccttgtcgaa 1501321 ttaatgcgcc atttgacggt agatgatcaa attcctgaag ctctttatga aacggtagcc 1501381 gagatttttt cattcattta caaattggac gaaagcgtaa aaaacaaaaa atagctaaaa 1501441 tattccccat ccttctttga aatttatgtt tttaataaag taaaagtttg aatgtttaga 1501501 aggattaaaa gattttgcat cgaactgtag acaattcttc cagtattatt atagaatgaa 1501561 agcgcagtct attttagttt tgttacataa gttaggagga tgggaaatga atatccatga 1501621 gtaccaggga aaagaagtcc tcagaaaata tggggtatct gttcctgaag gtaaagtggc 1501681 ttttacagca gaagaagcag ttgagagtgc aaagagctta tccagctcgg tttatgtcgt 1501741 aaaggctcaa attcatgctg gcggtcgagg caaagctggt ggggtaaaaa tagcaaaatc 1501801 attagacgaa gtaaaagcgt atgccgaaga actattaggg aagaccctag ttacacatca 1501861 gacgggtccg gacggccaag taataaaacg cttacttatt gaagaaggct gcgatattaa 1501921 aaaagaatat tacatcggtc tagtgcttga ccgcgccact tcaagaatcg ttttaatggc 1501981 ttctgaagaa ggcggaacgg aaattgaaga ggttgcggag aaaacaccag aaaaaatcaa 1502041 aaaagctgtc attgatccag ctgttggcct tcaaggctat caagccagag aaattgcatt 1502101 cgctattaat attccaaaag agctcgtggg aaaagctgct aaatttatgc ttggactata 1502161 taaagcgttt gttgagaaag actgctcaat cgccgaaatc aatccgcttg ttgtgactgg 1502221 cgacggaaat gtgatggcgc ttgatgcaaa attgaatttt gacagcaatg cgttgtaccg 1502281 acaaaaggac attatggaat acagagattt ggatgaagaa gatccgaaag aaattgaagc 1502341 gtccaaatat gatctaagct acatttccct tgatggaaat atcggctgta tggtaaacgg 1502401 cgcgggactt gcaatgtcta cgatggatat tatcaagcat tatggaggag aaccggccaa 1502461 cttccttgat gtgggcggcg gtgcaaccgc ggaaaaagtc acggaagcat ttaaaatcat 1502521 tctttctgat caaaacgtta aagggatttt tgtcaacatt ttcggcggca ttatgaaatg 1502581 tgatgtcatc gcagaagggg ttgttgaagc gactagacaa gttggtttga cattgccgct 1502641 tgtcgtccgt cttgaaggca caaacgtgga tctagggaag aaaatcctta gtgaatcagg 1502701 attaaacatt acatctgcgg aatcaatggc tgacggcgcg cagaaaatcg tatccttagt 1502761 ttaagaaaga atgaaaggca ggggaccaaa taatgagtgt tttcattaat aaagatacaa 1502821 gagttattgt gcaagggatt acaggttcta ccgctttatt tcatacgaag cagatgcttg 1502881 aatacggcac aaatatcgtt ggcggtgtaa cacctggaaa aggcggaaca gaagcggaag 1502941 gtgttcctgt atttaataca gtggctgaag cagttcaaac aaccggcgct aacgcgtctg 1503001 ttatatatgt gcccgcaccg tttgcagctg atgcgattat ggaagcggta gatgcggagc 1503061 ttgatctcgt gatttgtatc acagaacata tcccggtttt ggatatggtg aaggtcaaac 1503121 gcttcatgga aggcaagaaa acgagactga tagggccgaa ctgtcctggt gtcattacgc 1503181 ctgaagaatg taaaatcggc attatgcccg gatacatcca taaaaagggt catgtaggcg 1503241 ttgtatcacg ttcaggaaca ttaacatacg aagcggtgca ccagctctca gaagcgggtg 1503301 tagggcaatc tacagctgtt ggaatcggcg gcgaccctgt aaatggaaca aactttattg 1503361 acgttttaaa agcgtttaac gaagatcctg acacacacgc agtcatcatg attggcgaaa 1503421 tcggcggtac ggccgaagag gaagcggcag agtgggtaaa agccaacatg acaaaaccgg 1503481 tagtcggttt tattggcggt aaaacagcac ctcctgggaa gcgcatgggg catgcaggcg 1503541 ccattatttc cggcgggaaa gggacagctg atgaaaaaat caaaaccctt aatgcatgcg 1503601 gaatcgaagt tgcagagaca ccttctgtca tgggtgaaac cttaatcaag gtgctgaaag 1503661 agaagaactt gttcgaaact tgtaaaacgc attaataaaa aagggacagc cgtcaaggct 1503721 gttcctgctt tttctaacaa aaggaggtca atctattgga tcaggccgct gtctgcctaa 1503781 cgatttgcag aatcaatcaa ttattatccc catcccttct attaaaatgg tggaaagccg 1503841 atccgtctat gtcgctgaca tcacccgtgt tacaaacggt tactcgtgat caaataaaag 1503901 cagctgcatt aaaaaacgaa atagaacaat tttatccaaa gctcccgcgt gtacttgctg 1503961 cttatcgtga gcaaggcatt aacaccatcc ctatttcttc aaagcaatat cctttctggc 1504021 ttaaaagcat ttatgatccc cctgccgtac tgtttgcaaa aggtgatatg actcttcttt 1504081 cgaaagggag aaaaattgga attgtaggca caagaaatcc aacagcttat gggaaacaag 1504141 ttgtcaatca tcttacaaaa gagatctgtc gtaaaggttg ggtgattgtc agcggactgg 1504201 cgtctgggat agacggaatg tcccatgctg caagtattaa ggcgaagggg cggacaattg 1504261 gcgtcattgc aggcggattt caacacattt atccccgaga aaaccttcag ttagcagatc 1504321 acatggctaa acaccatatc ctgctgtcag agcacccacc tgaaactaaa ccccaaaaat 1504381 ggcatttccc tatgagaaac cgtattatca gcggactaag tgaaggcgtt attgtcgttc 1504441 agggcaaaga aaaaagcggt tcgctgatta ctgcctatca agcattggaa caagggagag 1504501 aggtatttgc cgtacccggt tcattgtttg acccttacgc cggaggtcct ataaaactga 1504561 tccagcaggg ggctaaagcc atatggtcag cagaggatat tttcgaggaa cttcctgaga 1504621 gaaacgttca atatacggaa cccttttgaa ttatcgtttg acaaacggta ttgtaatatt 1504681 taataatagt gaggatttaa agttgcatat tgttttctat ttaattaatg acgttcatga 1504741 taaagaatga aatgttgaaa gccaaataaa gacagctgca aaaataaaat tgaaatatct 1504801 tgaaaagaga gagaacacct cttgaggggg atgaaaatgt ctgattatct agtcatcgtg 1504861 gaatcgcccg ctaaggcgaa aacgattgaa cgttacttag gtaaaaaata taaagtaaaa 1504921 gcatcaatgg gacatgtccg ggatcttcca aaaagtcaaa tgggagttga catagaacag 1504981 aattttgaac cgaaatatat taccattcga ggtaaaggcc cggtattaaa agagctgaaa 1505041 acggctgcga aaaaagccaa aaaagtgtat ctcgcagctg accccgacag agaaggggaa 1505101 gcgattgcat ggcatttggc acacagtctt gatttagatc tcaactcaga ctgccgtgtg 1505161 gtgtttaacg aaattacaaa agacgctatt aaggaatcgt ttaagcatcc ccgcatgatc 1505221 aatatggatt tagtggatgc acagcaagcg agacgtattt tagacaggct tgtcggatat 1505281 aaaatcagtc caatcttatg gaaaaaagtc aaaaaagggc ttagcgcagg acgcgtgcaa 1505341 tccgttgccc tccgtttgat tattgaccgt gaaaaagaga ttaacgactt taagcctgag 1505401 gaatattgga caattgacgg tacgttctta aaaggtcaag aaacctttga agcgagcttt 1505461 ttcgggaaaa acggcaaaaa acttccttta aatagtgaag ctgatgtaaa agagattctt 1505521 tctcagctca aagggaatca atatacagtt gaaaaagtaa ccaaaaagga acgcaaacgt 1505581 aatcctgctt tgccttttac cacttctacc ctgcagcagg aagcggctcg caagctcaat 1505641 ttcagagcga agaaaacgat gatgattgca cagcaattat atgaaggaat tgatttagga 1505701 agagaaggaa cggttggtct gatcacgtat atgagaacgg attcaacccg tatttcaaat 1505761 acggctgttg atgaagcagc tgcatttatt gatcagacat atggaaaaga gttcctaggc 1505821 ggaaaacgga agcctgcgaa aaagaatgaa aatgcccagg atgcccacga agcaattcgg 1505881 ccgacatcag ttcttagaaa accaagtgaa ttaaaagcag tcctcggcag agaccaaatg 1505941 agactgtata aattaatttg ggagcgtttt gttgccagcc aaatggcacc ggctgttctc 1506001 gatacaatga gtgtcgacct gacaaacaac ggtttgacat ttcgtgcaaa tggaagtaaa 1506061 gtcaagtttt ccgggtttat gaaggtgtat gttgaaggaa aagacgatca aatggaagaa 1506121 aaagaccgga tgctgcctga cttacaagaa ggcgacacgg tattatcaaa agatatagaa 1506181 cctgagcagc attttaccca gccgcctccg cgatatactg aggcccggct tgttaaaacc 1506241 cttgaagaac gcggtatcgg ccgtccatcc acatatgctc cgacacttga tactattcag 1506301 cggcgcggct acgtggcatt ggataataaa cgtttcgttc cgactgaatt aggtcagatc 1506361 gttcttgact tgatcatgga gtttttccct gagatcatta acgttgagtt tacagctaaa 1506421 atggagagag atcttgatca tgttgaagaa ggaaataccg aatgggtcaa gattatcgat 1506481 aatttctaca ccgattttga aaaacgcgtc aaaaaagccg aatcggaaat gaaggaagtt 1506541 gagattgaac cagagtatgc tggagaggat tgtgaattgt gcagttctcc aatggtatat 1506601 aaaatgggac ggtacggtaa attcttagct tgctccaact tccctgactg ccggaacacg 1506661 aaaccgattg tgaaacaaat cggtgtgaag tgcccgagct gcggagaagg aaacattgtt 1506721 gagcgaaaat cgaaaaagaa acgggtgttt tacggctgtg accgttatcc ggactgtgaa 1506781 ttcgtatcat gggacaaacc aattgaacga aaatgcccga aatgcggaaa aatgctcgtc 1506841 gagaaaaaac tcaaaaaagg tatacaagtc caatgcgtgg aatgcgatta taaggaagaa 1506901 ccacagaagt agcggtgagc agggtcttgc tcaccttctt tgtgtgttaa aagaaggcct 1506961 tgaataataa actaggagat gtgaaagatg aaccaacaaa cagtgaatgt aatcggagcc 1507021 ggactcgcag gaagtgaagc agcatggcag cttgccaaac gtgggattca agtcaaattg 1507081 tatgaaatgc ggccagttaa acaaacgcct gcgcatcata cagataaatt tgctgagctt 1507141 gtctgcagca actctcttcg ctctaataca cttgctaacg ctgtcggtgt attaaaggaa 1507201 gaaatgcgtg cgcttgattc agccattatc gctgcggctg acgaatgttc ggtgcctgcc 1507261 gggggcgctc ttgcagtaga ccgtcatgaa tttgccgcaa gtgtgacaaa tcgggtgaaa 1507321 aatcatccaa acgtaaccgt tattaatgaa gaagtgactg aaattcctga aggccctact 1507381 atcatcgcaa cgggtccgtt aacatctgaa tcgctgtctg cccagctgaa ggagctgact 1507441 ggagaggact atttatattt ttatgacgca gcggcgccaa ttgtagaaaa agacagcctt 1507501 gatatggata aagtgtacct gaaatcccgt tatgataaag gtgaagcagc atatttgaac 1507561 tgcccgatga cagaagaaga gtttgaccgt tttcatgaag cattaacatc agcagaaaca 1507621 gtgccgttaa aagaatttga aaaagagatt ttctttgaag gctgcatgcc gattgaagtc 1507681 atggcaaaac ggggtaagaa aacaatgctt ttcggtccga tgaaaccagt tggtctagag 1507741 catcctgtta caggaaaacg cccttatgcc gtcgttcagc tcagacagga tgatgctgcg 1507801 ggaacacttt ataatattgt aggattccag acacatttaa aatggggaga ccaaaaggaa 1507861 gttctcaagt tgattccagg acttgaaaat gtagaaatcg tcagatatgg cgtgatgcat 1507921 agaaacacat ttattaactc tccaagcctg ttaaagccga cttatcaatt taaaaaccgc 1507981 agtgatctgt tctttgcagg ccaaatgacg ggagtagaag gatatgtgga atcagctgcc 1508041 tcaggacttg tagcaggcat taatgcggcg aagcttgtat tgggagaaga gcttgtgatc 1508101 ttccctcagg aaacagcaat tggcagtatg gcacattata ttacaacaac aaaccagaag 1508161 aacttccagc cgatgaatgc aaactttggg cttttgaaag aattgccagt taaaattaaa 1508221 aataaaaaag aacgaaatga acaatacgcg aaccgtgcga ttgaaacaat tcaaacaatt 1508281 tcgaaaacaa tataggtatt gattgcaacc tgagcgcgat ttgtgatacc atttaaaagc 1508341 ccttcctggg gaggtattag gcatggagaa tgttaagaat ttcgtaaagt tattcgttga 1508401 atatttacaa attgaaaaaa attattcaca atatactatt gtgaattatg tggattcaat 1508461 tgaagaattc gagactttcc tgcgcgttca aggtataaat ggatttgaag aagctgcata 1508521 tcaagatact aggatttttt tgacagaagc ctatgaaaaa ggtttatcga gaagaacaat 1508581 aagcaaaaag atatctgcat taagaagctt ttataagttt ctgatgcggg aaaagcttat 1508641 tgaagaaaat ccgtttcagc ttgttcatct gccaaaacag gagaaacgga taccgaagtt 1508701 tctatatcaa aaagagcttg aggagctgtt tgaagtttca gatataagcc agccggccgg 1508761 aatgagggat caagcgctgt tagagctgct ctatgccact ggaatgaggg tcagtgaatg 1508821 ctgttccata actattaacg acgttgattt atttatggac actgtgcttg ttcacggtaa 1508881 aggcaagaag cagcgctata tcccctttgg gtcttatgcc cgcgaagcgt tgaaggtata 1508941 catgaatagc ggaagacagt gcttgctgat gaaggcaaaa gaacctcatg atctattatt 1509001 cgtaaatcaa agaggcggac cgcttacagc ccgtggcatc agacatattt taagcgggct 1509061 tgttcaaaaa gcgtcaagca ctttacatat ccatccgcat atgcttcgac atacgttcgc 1509121 cacgcatctg ttaaatgaag gagcggattt gagaagcgtt caagaactgc tcgggcattc 1509181 caatctgtct tctacacaga tatacacgca cgtttcgaag gaaatgttga gaaacacata 1509241 tatgtctcac catccaagag catttaagaa aaattaaagg aggcccttta tgtcatcttt 1509301 tcatgcgacc acaatatttg ccgtacagca taaaggacga agcgctatgt ccggagacgg 1509361 ccaagtaaca tttggtcagg ctgttgtcat gaaacacacg gcacggaaag tgagaaaact 1509421 gtttaacggc aaagttcttg ctggttttgc gggatctgtt gcagacgctt tcactttatt 1509481 cgaaaagttt gaagctaagc ttgaagaata taacggcaac ttaaaacggg cggctgttga 1509541 gcttgcaaag gaatggcgca gtgataaagt gctaagaaag ctcgaagcca tgctgattgt 1509601 tatgaatcag gatactttgc ttctcgtatc gggaacaggc gaggtgatcg aaccagatga 1509661 cggcattctc gcgattggat caggaggcaa ttacgctttg gcagcgggaa gagcactgaa 1509721 aaagcatgcc ggggaaagca tgtctgcaag tgagattgcc agagccgcgt tagaaacagc 1509781 aggcgaaatt tgtgtttaca cgaacgatca aatcatactg gaagagcttg aatagaaagg 1509841 acttgaggcg catggaaaaa aaaccgttaa ctcctagaca gattgtagat cggttagacc 1509901 aatatattgt cggtcagcaa aatgcgaaaa aagctgtcgc cgtggcatta agaaaccgct 1509961 atagaagaag tcttctggat gaaaagctga aggacgaggt cgttccgaaa aacattttaa 1510021 tgatgggtcc taccggcgtc gggaaaactg aaattgccag acgaatcgct aagctttcag 1510081 gtgcgccatt tatcaaaatt gaagctacta aatttaccga agtcggctat gtaggcagag 1510141 atgttgaatc aatggtcaga gatcttgtgg agacttctgt tcggcttata aaagaagaga 1510201 aaatgaatga agtaaaggaa caggcagaag aaaatgcaaa caaacgcatt gttcgtctgt 1510261 tagttcctgg gaagaaaaaa caatctggtg ttaaaaatcc gtttgaaatg ttttttggag 1510321 gcagccagcc gaatggtgaa gatgaggcgg agagccagga agaagcaaac atcgaagaaa 1510381 aaagaaaacg aatggcgcat cagctggctt taggagagct cgaagactac tatgtaacag 1510441 tagaagtcga agaacagcag ccttctatgt ttgacatgct gcagggctcg ggtatggagc 1510501 agatgggtat gaacatgcag gatgcgctga gcggattaat gccaaagaaa aagaagcggc 1510561 gcaaaatgac agtcagagaa gccagaaaag tcctgacgaa tgaagaagca agcaaactca 1510621 tcgatatgga tgaagtcggc caggaagctg ttcagagagc agaagagagc gggattatct 1510681 ttatcgatga gattgataaa atcgcaaaga acggcggtgc atcttcttct gccgatgttt 1510741 caagagaagg tgttcagcgg gatatccttc cgattgttga aggttctacc gttgtcacaa 1510801 aatatggttc tgtaaaaaca gaccatgtat tatttattgc agcaggagcg tttcatatgg 1510861 ccaaaccgtc tgatttgatt cctgagctgc aggggcgttt cccgattcgt gtagaactga 1510921 acaaactcac ggtagacgac ttcgtgagaa ttttggttga gccggataat gcgctgctga 1510981 aacaatatca ggcattattg cagacagaag gtatatctct tgaattttct gacgaagcta 1511041 ttcataagat tgctgaagtt gcttatcatg tgaaccagga cacagataat atcggtgcga 1511101 gacgccttca tacaatactt gaacgcctat tagaagattt gtcgtttgaa gctccagatg 1511161 taacgatgga gaaaataacg attacaccac agtatgtcga agaaaagctc ggaacgatag 1511221 ccaaaaacaa agatttaagt caatttatat tgtgaaaaat ttaatatgag gaatgtttag 1511281 gaggattatt tatcatggct ttattacaaa aaacaagaat tattaactcc atgctgcaag 1511341 ctgcggcagg gaaaccggta aacttcaagg aaatggcgga gacgctgcgg gatgtaattg 1511401 attccaatat tttcgttgta agccgcagag ggaaactcct tgggtattca attaaccagc 1511461 aaattgaaaa tgatcgtatg aaaaaaatgc ttgaggatcg tcaattccct gaagaatata 1511521 cgaaaaatct gtttaatgtc cctgaaacat cttctaactt ggatattaat agtgaatata 1511581 ctgctttccc tgttgagaac agagacctgt ttcaagctgg tttaacaaca attgtgccga 1511641 tcatcggagg cggggaaaga ttaggaacac ttattctttc gcgtttacaa gatcaattca 1511701 atgacgatga cttaattcta gctgaatacg gcgcaacagt tgtcggaatg gaaatcctaa 1511761 gagaaaaagc agaagaaatt gaagaggaag caagaagcaa agctgtcgta caaatggcta 1511821 tcagctcgct ttcttacagt gagcttgaag caattgagca catttttgag gagcttgacg 1511881 gaaatgaagg tcttcttgtt gcaagtaaaa ttgctgaccg tgtcggcatt acccgttctg 1511941 ttattgtgaa cgcactcaga aagctggaga gcgccggtgt tatcgagtct agatcattag 1512001 gaatgaaagg tacttatatc aaggtactaa acaacaaatt cctaattgaa ttagaaaatc 1512061 taaaatctca ttaatcacaa aaagaaccct ttttgagggt tcttttttta tttcaaataa 1512121 aggaaatcaa taagctttat ttcctgggtt gaaagtcttt ctatgtaata attttaataa 1512181 attttgcatt tttcttcaaa aagtttcaaa aatgccgaaa agaaaggaga aaaaacagaa 1512241 attctgctat tttcaggctt atatcaaggc gagaaatgta gttctaacaa tctaggactt 1512301 tatacctagt tgcaaaatag ataattgtga ggacattttt ttacacgaac ttcatagact 1512361 ttatgcctgt tatttcttac aataagcata tagttttaca attctcgaca aggatattga 1512421 gggtgaaaaa aactgaaatg gaggtaagtg gatttgagct tattttctgg aacgatacaa 1512481 aatcttgaaa atgccttgag cagagcggat attaagcaaa aagtcataac taataatatc 1512541 gccaatatag atacaccgaa ctataaggca aaaaaagtct ctttccaaaa tttattagat 1512601 caagaatcct cgcgtcttga agcgataaaa acagactatc gtcatgttga tttttctgat 1512661 actgattcga attattcaat tgttgcgagc ggagatacat cgtatcagca aaacggaaac 1512721 aatgttgatg ttgacaaaga gatgacagaa ttggcgcaaa atcaaatcaa ctatcaagct 1512781 ttggttgaaa gaatgaacgg taaatttaat tcgctgaaga ccgtattaac aggaggaaaa 1512841 tgatgacagc ttttcatagc ttaaatgttt cagcatcggc tttaacagct cagcgagtca 1512901 gaatggacgt tgtatcatct aacttagcaa atatggatac gacaagagct aagcaggtga 1512961 atggagagtg ggtgccttac agaagaaaaa tggtttccct tcagtcaaaa ggtgaatcgt 1513021 tctcttccat tctcaattct caaatgagcg gaagcgggaa tgctggaaac ggtgtgaagg 1513081 tttcaaaaat tacggaggat gattcggatt ttaatcttgt ctatgatccg acagaccctg 1513141 atgcaaacgc tgaaggatat gtacaaaagc ctaatgttga tccattaaag gaaatggttg 1513201 atcttgtcag cagcactaga tcatacgagg cgaatgtcac ggcgatgaat gccacaaagg 1513261 gaatgctgat gaaggcgtta gaaatcggaa agtaggcgaa ctgttaaaca aggtgaaaaa 1513321 acgatttaat taaggtatta gggggataac aatgcaatcc ttgaattatg aagatcaggt 1513381 gctttggacg cgctggaaag agtggaaaga tcctaaagcc ggtgacgact taatgcgccg 1513441 ttacatgccg cttgtcacat atcatgtagg cagaatttct gtcggactgc cgaaatcagt 1513501 gcataaagac gatcttatga gccttggtat gcttggttta tatgatgccc ttgaaaaatt 1513561 tgaccccagc cgggacttaa aatttgatac ctacgcctcg tttagaattc gcggcgcaat 1513621 catagacggg cttcgtaaag aagattggct gcccagaacc tcgcgcgaaa aaacaaaaaa 1513681 ggttgaagca gcaattgaaa agcttgaaca gcggtatctt cggaatgtat cgcccgcgga 1513741 aattgcagag gaactcggaa tgacggtaca ggatgtcgtg tcaacaatga atgaaggttt 1513801 ttttgcaaat ctgctgtcaa ttgatgaaaa gctccatgat caagatgacg gggaaaacat 1513861 tcaagtcatg atcagagatg acaaaaatgt tccgcctgaa gaaaagatta tgaaggatga 1513921 actgattgca cagcttgcgg aaaaaattca cgaactctct gaaaaagaac agctggttgt 1513981 cagtttgttc tacaaagagg agttgacact gacagaaatc ggacaagtat taaatctttc 1514041 tacgtcccgc atatctcaga tccattcaaa ggcattattt aaattaaaga atctgctgga 1514101 aaaagtgata caataatgaa tttcatggtt agcgagtgaa aaacatgtca acactattat 1514161 ggcttttaag ctttatgctc cacggcgttc ttctgtacgc tgtcattatc ctgtatacga 1514221 ggctcgctgc agtgaaagaa acagaaaaac agcaaaaaca gatacttgaa gagacggaaa 1514281 acaccttggc ggcatttctg cttgaattaa aagaagaaaa tgagaaactg atagaaaata 1514341 aagcttcatc tgcaagtcaa tcagatgaag aatcccaaaa gtcaggcctt cagacctctg 1514401 aaacatatca agagcgggat ccagtccaag aggcagagaa tcttcctgaa catattgaag 1514461 gtctgattac agaggttgac cgtcgggaag agctcgtaaa cagtgaggtc caatcatttg 1514521 aagaccaggt catagaatta tatgaacagg gatattcggc aagtcaaatt gcccagaaaa 1514581 tgaagagcgg aaagacagaa atcgagctat ttttaaaatt tcgctccaaa ggtgtaaagg 1514641 attcttgatt gtcggataaa gctgtgttat attatgtctt ggtgttaaat acacacgctt 1514701 aacgatttat gcagagggtg ctgcaggcgg cagttctgta caaaaatgac ctaagcggag 1514761 gaaaaaaacc attatattag gaggaaataa catgtcagtc atttctatga agcaattgct 1514821 tgaagctggt gttcacttcg gtcaccaaac acgccgttgg aacccaaaaa tgaagcgtta 1514881 cattttcacg gagcgtaacg gaatctacat cattgacctt caaaaaacag tcaaaaaagt 1514941 agaggaagct tacaacttca ctaaaaatct tgctgctgaa ggcggaaaaa tccttttcgt 1515001 cggaacaaaa aaacaagctc aagattctgt taaagaagaa gctcaacgct ctggcatgta 1515061 ctatgtcaac caacgctggt tgggcggtac attaacaaac ttcgaaacaa tccaaaaacg 1515121 tattaaacgt cttaaagaca ttgaaaaaat gcaagaaaac ggtacgtttg atgtacttcc 1515181 taaaaaagaa gtcgttcaat tgaaaaaaga attagagcgt cttgaaaaat tcctaggcgg 1515241 aattaaagat atgaaggatc ttcctgatgc attattcatc atcgatcctc gcaaagagcg 1515301 catcgctgtt gcggaagctc gcaaattaaa catccctatc atcggtatcg tagatactaa 1515361 ctgtgatcca gatgaaatcg atgttgttat cccagcgaac gatgacgcta tccgcgctgt 1515421 taaacttcta acttctaaaa tggcagatgc aatcttagaa gcgaagcaag gcgaagaaga 1515481 agcggaagtt gctgaagaaa ctgcaccaga aacagaaaca acaactgcgt aacctattca 1515541 aaaggtgata agagggactg ccttttatca ccttttttca agaaaaatgt gtaatataca 1515601 tactcttgtt taaacatata aggaggaata caaatggcaa ttactgcaca gcaagtaaaa 1515661 gaactgcgtg aaaaaactgg cgcgggcatg atggattgta aaaaagcgtt aactgaaact 1515721 gacggagata tggacaaagc aattgacctt ttaagagaaa aaggaattgc aaaagcagcg 1515781 aaaaaagctg accgtatcgc agcagaaggt tctactctta ttaaaactga cggcaacaaa 1515841 ggcgttatcc tagaagtaaa ctctgaaact gatttcgttg cgaaaaacga aggttttaaa 1515901 gagcttctta acactttagc tgaccacctt cttgcaaaca cgccagctga tgttgaagaa 1515961 gcaatgggcc aaaaaatgga aaatggctca actgttgaag agtacatcac aagcgcagtt 1516021 gctaaaatcg gtgagaaaat cactcttcgc cgctttacag ttcttacaaa agacgacagc 1516081 tctgcattcg gtgcgtacct tcacatgggc ggccgcatcg gtgtattaac tgttctcaac 1516141 ggtacaactg atgaagaaac tgcgaaagat atcgcaatgc acgttgctgc agttaaccct 1516201 cgttacattt ctcgtgatca agtatctgaa gaagaaacaa atcatgagcg tcaaatctta 1516261 actcagcaag ccctccaaga aggcaaacct gaaaacatcg tagcgaaaat ggttgaaggc 1516321 cgtctgaaca aattcttcga agaaatttgt ctattagacc aagcgttcgt taaaaaccca 1516381 gatgaaaaag tgaaacaagt tattgcagcg aaaaacgcta ctgttcaaac ttttgtccgc 1516441 tatgaagttg gagaaggcat cgaaaaacgt caagaaaact ttgctgaaga agtaatgaac 1516501 caagtgaaaa aataatggtg aaaagatttc gcggctaagt cgcgtctttt caggcagtat 1516561 aggggacaca ttttgtgttc cctattttta aaactatatt tacaaacctt tttttctctt 1516621 gcataataga aaacggcaat gtttacactt ggaggttatc atggaaaaac caaaatacaa 1516681 acgtatcgta ttaaagctta gcggggaagc attggcagga gaacagggaa atggaattaa 1516741 cccgactgtc attcaatcca ttgcaaagca agtgaaggaa atcgctgagc ttgaagtcga 1516801 agtggctgtt gttgtaggcg gcggcaactt atggcgcgga aaaacaggaa gtgacctggg 1516861 catggaccgc gcgactgctg actatatggg aatgctggcg acagtaatga attcgcttgc 1516921 tcttcaagac agcttggaaa cactcggaat ccagtccaga gtgcaaacat ccattgaaat 1516981 gagacaagtt gctgaaccgt acataagaag aaaagcgata cgccacttag agaaaaaacg 1517041 tgtcgttatt ttcgctgcgg gcacaggaaa cccatatttc tcaactgata cgacagctgc 1517101 actgcgggct gctgaaattg aggcagacgt tattttaatg gctaaaaata acgttgacgg 1517161 tgtgtataat gctgatccta gaaaagatga atcagctgtt aagtatgaat cactttctta 1517221 tcttgacgtt cttaaagacg gcctggaagt catggattca acagcttcct ctttatgcat 1517281 ggacaatgac attccgctta tcgtcttttc tattatggaa gaaggaaata tcaaacgtgc 1517341 cgttatcggt gaatcaatcg gaacgatcgt gagggggaaa taacgtgtca aaagaagtat 1517401 taactcaaac aaaagaaaaa atggaaaaag caattgctgc ttatcagcgc gaattggcta 1517461 ctgtacgcgc aggccgtgca aatccatcat tattagataa agtaacggtt gaatattacg 1517521 gagcgcagac acctttaaat cagttgtctt ctattaacgt gcctgaagct cgtatgctcg 1517581 ttatcacgcc atacgataaa acagcaatcg gtgatatcga aaaagcgatt ttaaaagctg 1517641 atttaggtct tacaccaaca agtgacggca atatgattcg aattgcaatt ccggcactaa 1517701 cagaagagag acggaaagaa ttagtgaaag ttgtaaaaaa atatgctgaa gaagcaaaag 1517761 tagctgttcg taacgttcgc cgtgatgcta acgatgatct caaaaaactt gagaaaaacg 1517821 gagacattac tgaggatgaa ctgcgtgctt ccactgaaga cgttcaaaaa ctgacagatg 1517881 aatatgtgtc aaaaattgac agtgtcacaa aagacaaaga aaaagaaatc atggaagttt 1517941 aatgaaaaac tatgtacaat agataatagt gaaaagaccc tctcatgttt acagggggtt 1518001 tttttgttaa tactgttgat tacattgatt atcagcaggg aatgtaacct ttttgggtga 1518061 cggaggaatc tcatgctcaa catactcaaa aattggaaga atcagcaaac tgcggcttcc 1518121 aacttagaac gttatacaaa agaagacata cttaagggag aaattcccga acacatcgcc 1518181 attatcatgg atggaaatgg ccgttgggct aaaaaacgct ctcttcccag aattgcaggc 1518241 caccatgaag ggatgaaggt ggtaaaaagg accacgaagc tcgcaaacga attaggtgtc 1518301 aaagtactga cattgtatgc attttcaaca gaaaactgga aaagaccgaa aatggaggtc 1518361 gattttttaa tgaagcttcc ggaagaattt ttgaatacgt atcttccaga gcttgttgag 1518421 gaaaatgtac aggttcggat cattggggat gaaacggctt tgccggcgca cacattacgt 1518481 gcgattgaaa aagctgtaca ggacacggcg caaaacgacg gaatgatcct taattttgct 1518541 cttaactatg gaggccgtac tgaaattgtc agtgctgcaa aatcactcgc ggaaaaagtg 1518601 aaggaaggct ctttgaatat tgaagacatt gatgaatcgc ttttttctac ttatttgatg 1518661 actgaatctt tgcaggatcc tgaactttta attcgaacga gcggcgagat aaggctgagt 1518721 aattttatgc tatggcaggt tgcctacagt gaatttgtct ttactgacgt cttgtggcct 1518781 gactttaaag aagatcactt cttgcaggcg ttaggagagt ttcagcagag aggccggagg 1518841 tttggcggaa tttagaggat ggtggacatg aaacaaagaa ttttgacagg tgttctggca 1518901 gcaattgtat ttttattttt ggttattgtc gggaaattgc cgttcaccat attaatttat 1518961 gctatgggca gtgtggcgct ttttgaactt ttacggatga aaaagctgaa gctggtttca 1519021 ctgccgggtt tgatcggtct tttattattg tggatgttct tattaccaag ccagtattcg 1519081 ttttttgaag cggacgggat ttccaaaatg gaaatcgctt tatttgcggt actgctattg 1519141 ctgacttaca cagtgttggt caagaacacc tttacttttg atgaagtcgg gtttattacg 1519201 cttgcagcaa tttacatcgg aatgtgtttt cattatttta tcgaaatcag aaatcttgac 1519261 caatacggat taacatacat tttttatgcg tgtgttgtca tttggtccac cgattccggt 1519321 gcctattttg tcggtaaatc gcttgggaag cggaaactgt ggcctgaaat cagtccgaat 1519381 aaaacagtgg aagggtttgc aggcggaatt gtcatcgcac ttgtattggc gacgattttt 1519441 cagcttgttg cacaacttcc gatcccgtat atctatctgc tgttgatcac gctgtttttg 1519501 tctgtttttg gacaactggg agatttagtg gaatccgcct tgaaaagaca ttacgatgta 1519561 aaggattctg ggaatattct tcccgggcat ggcggtatat tagaccgttt tgacagtttc 1519621 ttgtttgtca tgcctttctt gtactttctg cttgcccttt tttcataaaa aagtctaata 1519681 tgaatatgag actgatcatg cagcaataag aataggagta gtggcaactt tgaaaaatat 1519741 ttgtctttta ggagcaacag gatcaatcgg cgaacagact cttgatgtac tgcgtgcaca 1519801 tcaagaccaa tttcagctgg tatctatgtc gtttggcaga aatattgata aggccgttcc 1519861 aatgattgag gtctttcagc cgaagtttgt ctctgtcggt gatctggata catatcataa 1519921 attaaaacaa atgtcttttt cttttgaatg ccaaatcggg ctgggagaag aaggactgat 1519981 agaagcagca gtgatggagg aggttgacat tgttgtcaac gctttgcttg gaagcgtcgg 1520041 tcttatcccg acattaaagg caattgaaca gaaaaaaaca attgcgcttg caaataagga 1520101 aactcttgtc actgcagggc atatagtaaa agaacatgct aagaaatatg atgttccgct 1520161 gctgcctgtt gacagtgagc attcagccat ttttcaagct cttcaaggcg aacaggctaa 1520221 aaacattgaa cgcctcatca ttacggcatc cggcggaagt tttcgggaca agacgcggga 1520281 ggagctcgaa tcagtaacgg ttgaagatgc attaaaacat ccaaactggt caatgggtgc 1520341 aaaaattaca attgattcgg ctacaatgat gaataaggga ttagaggtga tcgaggcaca 1520401 ctggcttttc gatatacctt atgaacaaat tgatgtggtt ttacataagg agagcatcat 1520461 ccattcaatg gttgagttcc atgataaaag tgtgatcgca cagctcggaa ctccggatat 1520521 gagagtcccc attcaatatg cgctcactta tcctgaccga ttgccattac cagatgcgaa 1520581 aaggcttgaa ttatgggaaa tcggcagcct tcattttgag aaagctgatt ttgacaggtt 1520641 ccgatgctta caatttgctt ttgaatcagg taaaatagga ggaacaatgc cgacagtgct 1520701 aaatgcggca aacgaagtag ctgtcgctgc ctttttagct ggcaagatac cgtttttggc 1520761 tattgaagac tgtatcgaaa aggcactaac ccgccatcaa ttactgaaaa aaccgagcct 1520821 ggcggacatt caagaagtgg acaaagatac ccggggatac gtcaattcaa tactcacata 1520881 aggtggtatg ttcgtgaata cagttatagc gtttatcatt attttcggaa cgctcgtttt 1520941 cttccatgaa ctgggccatt tattgctagc ccaaagagcg ggaattctct gccgtgaatt 1521001 tgcgatcggc ttcggtccaa agattttttc tttcaaaaaa aatgaaacag tttatacgat 1521061 caggctgctt ccggtcggcg gatttgttcg tatggccggc gaagatccgg aaatgattga 1521121 ggtgaaaccc ggatacacgg tcgggcttct gtttaataag gaagatcaag ttgagaaagt 1521181 catcatcaat caaaaggaaa aatatccgga tgctttagtc attgaagtgg aaacagcgga 1521241 tctagagcat gacatgaaga tcaccggtta tgaacagggg aaagaggacg aactttccag 1521301 ctttactgtc agcgaaacat ccttttttat tgtagacgga gaagaagtgc agattgcgcc 1521361 gtataatcgc caatttggtt ccaaacctgt atggcagcgg attaaagcaa ttgctgcagg 1521421 gccgattatg aactttattt tagcttacgt cattttagtg atgcttgggc tgattcaagg 1521481 cgtaccgtca aatgaaccta tgctcgggca gctgacagac aatggacggg cggctgaagc 1521541 agggctaaaa gaaggggatt atatccaaag cattaacgga gagaaaatga ggtcttggac 1521601 tgacattgtc tccgctgtaa aagaaaaccc ggagaaagaa atggacgttg cagtaaaaag 1521661 agataacaaa acgcttcata tttcggtgac tccggaagct gttaaagatg agaacaaaaa 1521721 aacaatcgga cgtttcggtt cctatgcgcc gactgaaaaa ggcgtactct cagcggttgc 1521781 ttacggcgcg acatcaacag ttgatgtcac caaagccatt ttaaccaatc tgagcaaatt 1521841 agtaacaggc caatttaaac tcgatatgct gtcaggtcct gtcggcatat atgacatgac 1521901 agaccaagtg gcgaaaacag ggatcgtgaa cttatttcag tttgcggcgt ttttaagcat 1521961 taaccttggg attgtcaacc tgcttccgat tccggcactt gacggaggaa gactgttgtt 1522021 tctatttatt gaagcgattc ggggcaaacc gattaacagg gaaaaagaag catttgttgt 1522081 gtttatcgga gtagctttct taatgcttct tatgctggtt gtcacatgga acgatatcca 1522141 gcggctgttt ttgtaaacga aaagtaaatc aatcagaggt gcgaagaaat gagacaaagc 1522201 ttgacgctta ttcctacgct ccgtgaagtt ccagctgatg ccgaagcaaa aagtcatcag 1522261 cttcttctga gagcaggatt tatcagacag aatacgagcg gggtatacag ctatatgcct 1522321 cttgcgtata aggtgattca aaacattcag cagattgttc gagaggaaat ggagaaaatt 1522381 gatgccgtag aaatgctcat gcccgcattg cagcaggcag agacatggca ggaatcaggc 1522441 agatggtata cgtatggtcc cgaactgatg agactaaaag accgtcatgg ccgtgaattt 1522501 gctttagggg caacgcatga agaggttatc acttcgcttg ttcgcgatga ggttaaatct 1522561 tataagcgtc tccctctgac tctttatcaa attcagtcta agttcagaga tgaaaaacgt 1522621 cctcgcttcg gtttgttaag aggccgcgaa tttattatga aggatgcgta ctctttccat 1522681 gcatctgcag agagcctgga tgaaacgtat caaaaaatgt acgaggccta ttctaatatt 1522741 tttgcccgct gcggcattaa tgtaagacct gttatcgctg attcaggcgc aatgggagga 1522801 aaggatacgc acgaatttat ggcactttct gcgatcggag aggatacgat tgcgtattct 1522861 gatgaatcac agtacgcggc taatatcgag atggctgaag ttcttcacca ggaagttcct 1522921 tcagatgaag agcctaaagc tctagagaag gttcatacgc ctaacgtgaa aacaatcgaa 1522981 gaactgactg cgttcttaca ggtttcggct gaagcgtgca ttaagtcagt attgtttaaa 1523041 gctgatgacc gttttgtctt agtgcttgta agaggggatc atgaagttaa cgatattaaa 1523101 gtgaaaaact tgcttcatgc agaagttgta gagcttgcta cacatgaaga ggtcattcag 1523161 cagctcggaa cagagccagg ctttgtaggc cctgtcggta ttcatcagga tgtggaagta 1523221 tatgccgatc aagctgtgaa agcaatggtt aatgctgttg ccggggcaaa tgaaggagat 1523281 catcattata aaaatgtcaa tgtgaatcgt gacgcgcaaa ttaaagaatt tgctgatctt 1523341 cgttttatta aagaaggtga tccttcacca gacggcaagg gaacgatccg ttttgctgag 1523401 ggaatcgaag tcggacaagt ctttaagctc ggaacacgct attcagaagc gatgaatgcg 1523461 acatatttag atgaaaacgg acgcgcgcag ccaatgctga tgggctgtta cggaatcggt 1523521 gtgtcaagaa cgctttctgc tattgctgaa cagcatcacg acgaaaaagg cttaatatgg 1523581 ccaaaaagcg ttgcgccgta cgatcttcat attcttgctt tgaacatgaa aaacgatggg 1523641 caaagagagc ttgctgaaaa gctgtatgcc gatttaaaag cggaaggcta tgaagtgctc 1523701 tatgatgacc gtgctgagcg tgccggcgta aaattcgctg attcagattt aatcggcctt 1523761 ccaatccgca tcactgtcgg aaaacgagct gacgaaggaa tcgtcgaagt gaaaattcgt 1523821 caaactggtg agtcaactga gatttcagta gacgaattat ctgcgtttat cagcaagcag 1523881 taatcaccat aacgatttat caaaaaacat gttaaaatag aaataataga aggtacctca 1523941 ttgcctgagg taccttcact tatgatgttt ttagggaggg atactgtctt aatggaacag 1524001 ttatcagtaa acagaaggca gtttcaaatt cttctgcagc agattaatat gacagatgat 1524061 accttcatga catactttga acatggcgag attaaaaagc tgacaattca caaagcttct 1524121 aagtcttggc attttcattt tcaatttaaa tctttgctgc cttttcaaat atatgacaca 1524181 ttaacaacga ggctgacgca atcgtttgcc cacatagcaa aagtgacatc ttcaattgaa 1524241 gttcaggatg ccgaggtcag tgaaagtatc gttcaagact actggtcacg ctgcattgaa 1524301 gaactgcagg gcatttcgcc gccgattatc agtcttttaa accagcaaaa accgaagctg 1524361 aagggcaata aactgattgt caaaaccaaa acagatacag aagcggctgc gctaaagaac 1524421 aaatacagtt ccatgattca agcagaatac cgtcaatttg gctttccgga tcttcagctt 1524481 gatgctgaaa tatttgtatc cgagcaagaa gttcaaaagt ttcgggagca aaagcttgcg 1524541 gaagaccaag agcgggctat gcaggccttg attgaaatgg agaagaaaga taaagaaagt 1524601 gatgaagacc aagcaccatc tggtcctctt gttatcggtt atcaaattaa agataacgag 1524661 gaaatccgaa cacttgacag catcatggac gaagaacgga gaattacggt ccaaggttat 1524721 gtgtttgatg tggagacgcg cgagctgaag agcgggcgca cgctgtgtat cttcaaaatt 1524781 acagactata caaatagtat tttgatcaaa atgtttgcac gtgaaaaaga agatgcggcg 1524841 ctgatgaagt ctctgaaaaa aggaatgtgg gtaaaagcac gcggaagcat tcaaaatgat 1524901 acatttgtca gagaccttgt catgatcgca aatgacgtaa acgaaataaa agcaaaaacc 1524961 cgtgaagatt cagcacctga aggagaaaaa agagtggaat tgcatcttca ttccccaatg 1525021 agccaaatgg atgctgttac gggtatcgga aagcttgtcg aacaggcgaa aaaatggggg 1525081 catgaggcca tcgctttgac cgaccatgct gtcgttcaat ccttccctga tgcgtattct 1525141 gcggccaaaa agcatggaat taaaatgatt tacgggatgg aagcgaatct cgtggatgat 1525201 ggcgtgccaa ttgcttataa tgccgcacat cgtctgctcg aagaagaaac atatgttgtt 1525261 tttgacgttg agacgacagg attgtctgct gtatacgata ccattattga gctggctgca 1525321 gtaaaagtaa aaggcggaga aattattgat aaatttgagg cgtttgcgaa cccgcatcgt 1525381 ccgctttccg ccacaatcat agagctgaca gggatcacag atgatatgct acaagacgct 1525441 ccggatgtcg tagatgtaat aagagatttc agagaatgga ttggcgatga tattcttgtc 1525501 gctcataatg caagctttga tatgggattc ttaaatgtag cctataaaaa acttcttgaa 1525561 gtcgaaaaag ctaaaaaccc agtcattgat acgcttgaac ttggacgttt tctctatccg 1525621 gaatttaaga accaccggtt gaacacactt tgtaaaaagt ttgatatcga gctcacacag 1525681 catcaccgtg cgatctatga tactgaggca accgcttatt tgcttctgaa aatgctgaaa 1525741 gacgcagctg aaaaaggtat tcagtaccat gatgagttga atgaaaatat gggtcagtcc 1525801 aatgcttatc aaagatcaag accgtatcat gcaacattac ttgccgtgaa cagcacggga 1525861 cttaaaaatt tatttaagct tgtgtcactt tctcatattc attattttta cagagtgccg 1525921 cgtattccga gatctcagct tgagaaatac agggaagggc ttctgatcgg ttctgcttgt 1525981 gacaggggag aggtttttga gggaatgatg caaaaatcgc ctgaagaggt ggaagatatc 1526041 gcgtcattct atgattacct tgaggttcag ccgcctgaag tgtatcgtca cttgctggag 1526101 cttgaactgg tccgtgatga aaaagcgctg aaagaaatta ttgcgaatat cacgaagctg 1526161 ggggaaaagc ttaataaacc ggttgttgct acgggaaatg ttcattactt gaatgatgag 1526221 gataaaatct acagaaagat tttaatatcc tcacaaggcg gggcaaatcc gctgaatagg 1526281 catgaactgc cgaaagtgca tttcagaacg acagacgaaa tgcttgaagc tttttctttc 1526341 ttaggtgaag aaaaagcgaa ggagatcgta gtcaccaata cccaaaaggt tgcttcttta 1526401 gttgatgaca tcaagccgat taaagatgat ttatatacgc cgaaaatcga aggcgctgat 1526461 gaagagatca gagaaatgag ctatcagcgt gcaagaagca tttacgggga agagctgcct 1526521 gaaattgtcg aagcgcggat tgaaaaagag ttaaagagta ttattggcca cggatttgct 1526581 gttatttact tgatctctca caaacttgta aaacgttcac tagatgacgg gtatctcgtt 1526641 ggttcccgtg gttccgtagg atcttcatta gttgcgacac ttactgagat tactgaggta 1526701 aacccgctgc cgccgcacta tgtttgtcct gagtgccagc attctgagtt ctttaatgac 1526761 ggttctgtcg gttctggttt tgacctgcct gacaagacat gccctcattg cggaacgcct 1526821 ttgaaaaaag acggccatga tattccattt gaaacgttct taggatttaa aggggacaaa 1526881 gtacctgata tcgatttgaa cttctcaggg gaatatcagc cgcaagcaca caattacaca 1526941 aaagtattgt tcggagaaga caatgtatat cgtgcgggaa caataggcac ggtggcagaa 1527001 aaaacagcct acggttatgt aaaaggctat gccggagaca acaatcttca tatgcgcggt 1527061 gccgaaatag atcggctcgt acagggatgc acaggtgtaa aacgtacaac tggacagcac 1527121 cctggcggta ttatcgtagt tccggattat atggatattt atgatttttc accgatccag 1527181 ttcccggcag atgccacagg ttcagagtgg aaaacgactc attttgattt ccactccatc 1527241 catgacaacc tgttaaaact tgatattctc ggacacgatg acccgactgt tattcggatg 1527301 cttcaagact taagcggaat agatccgaaa acaattccga cggatgatcc tgaagtgatg 1527361 aagatcttcc agggaaccga atcactcggt gtgactgaag aacagattgg ctgtaaaacg 1527421 ggcactcttg gaattcctga attcggaacc cgatttgtcc ggcagatgct tgaagataca 1527481 aagccgacca ctttttctga gctcgttcag atttcaggct tgtctcacgg aactgatgta 1527541 tggcttggca atgcacagga gctcatccac aataatattt gtgagctgag tgaggttatc 1527601 ggctgccgtg atgacattat ggtttattta atctatcaag gccttgagcc gtcccttgcc 1527661 tttaaaatca tggaattcgt gcgtaaagga aaaggattaa cgcctgaatg ggaagaagaa 1527721 atgaaaaata acaatgtccc agactggtat attgattcct gtaaaaagat taaatacatg 1527781 ttcccgaaag cccacgccgc ggcatatgtc ttaatggcag tccgcattgc ttactttaaa 1527841 gtgcatcatg ctcttttgta ttatgcggct tattttaccg ttcgtgcaga tgactttgat 1527901 attgatacaa tgatcaaggg ctctacagca atcagagcgg taatggagga tataaacgct 1527961 aaaggacttg atgcttcacc gaaggaaaag aaccttctga ctgttttaga attagcgctt 1528021 gagatgtgtg agagaggcta ttcattccaa aaagtcgatt tatatcgctc cagcgccaca 1528081 gagtttatta ttgacggcaa cagtcttatt ccgccgttta actctattcc agggttaggg 1528141 acgaacgctg ctttgaacat tgtaaaagct cgcgaagaag gcgaattcct ctcaaaagaa 1528201 gatttgcaaa agagagggaa agtatcaaaa acgattttag agtacttaga tcgccatggc 1528261 tgtctggagt cactgcctga tcaaaaccaa ttgtcactgt tctaatatgg aaagcagaat 1528321 ttctcagaaa ttctgcttct atgcatacat aagcgcaaaa agtgccatcg taatattaga 1528381 gtttctgtca cttgcttagg tatgaaggta agcgtatatc catttgcaat aaaaatatgg 1528441 ttatggtata gttttattgg aaatgctaac gattaccgag gcaaagagtg gggaaacccg 1528501 ctcttttgta ttgaacagga gaattttgtc tcgacatgtt catcgtttac tttttagccc 1528561 ctgctctttt gaagcagggt ttttatgcag agtgacgaga cgaatatgag atcgacagca 1528621 caaggaggaa gaacatgagc aaaaaagtga ctgacaccgt tcaagaaatg gctcagccaa 1528681 tcgtagacag ccttcagctg gaactcgttg acattgaatt tgtcaaagag ggccaaagct 1528741 ggttccttcg cgtgtttatt gattccgatg acggtgtgga tattgaggaa tgtgccaaag 1528801 taagcgaagc tttaagcgaa aagcttgatg aggcagaccc aatcagccaa aattactttc 1528861 ttgaagtctc atctccagga gctgagcgtc cgctaaagaa aaaagccgat ttcgaaaaat 1528921 cactaggaaa aaacgtatac attaagacgt atgagcctat tgacggcgta aaagtgtttg 1528981 aaggtgaact ggctgaattt gatggacaaa cagtgacagt tgagatcacg atcaaaacaa 1529041 gaaagaaacg gatcaatatt ccgtatgaaa agatagctaa tgcaagatta gctgttacat 1529101 tctaatgaat acaaatgttt taagggggga gaccgttaaa tgagcagtga attattagat 1529161 gctctcacga ttcttgaaaa agaaaaaggc atcagtaaag aaattatcat cgaagcaatc 1529221 gaagctgcgt taatttctgc ttataagcgg aattttaatc aagcgcaaaa tgtacgggtg 1529281 gatctaaacc gtgaaactgg ctccatccgt gtatttgcaa gaaaagatgt cgttgacgaa 1529341 gtatacgacc agagattaga aatctcaatt gaagaggcac agggcatcca tccggaatat 1529401 atggtcggcg atgtcgtcga aatcgaagtt acacctaagg atttcgggcg catagctgct 1529461 caaacagcga agcaggtcgt cacacagcgt gtgcgcgaag ctgagcgcgg tgtgatttat 1529521 tctgaattta tcgaccgtga agaagacatc atgacaggga tcgtccagcg tctggacaat 1529581 aaatttatct acgtgtcttt aggcaaaata gaagccttgc tgccggttaa tgagcaaatg 1529641 ccgaatgaaa gctacaagcc ccatgaccgc attaaggtat atatcacaaa agtagaaaaa 1529701 acaacgaagg gtccgcagat ttatgtgtca agaacacatc caggcctgtt aaagcgtttg 1529761 tttgaaattg aagtgcctga aatttatgat ggaactgtcg agctaaaatc tgttgccaga 1529821 gaagccggcg accgttcgaa aatttctgtt cgcacagatg atcctgacgt tgatcctgtc 1529881 ggttcatgcg tagggcctaa aggccagcgt gtgcaagcaa tcgtcaatga attaaaaggt 1529941 gaaaaaattg acattgtcaa ctggtccagt gatcctgtag aatttgtcgc gaatgcgctc 1530001 agcccttcca aagtgcttga tgtcattgtt aatgaagaag aaaaagcgac aactgttatt 1530061 gttcctgatt accagctgtc tctggcaatt ggaaaaagag gacaaaacgc acgcttagct 1530121 gctaaactga caggctggaa gattgatatt aagagcgaaa cggacgcaag agaacttgga 1530181 atctatccga gagaacttga agaagatgat gagccgctct ttacggagcc tgaaactgct 1530241 gaatcggatg aataagaggt gactttaggt gaataaacac aaaaagatcc cattacgcaa 1530301 atgtgtagtg actggtgaaa tgaagcctaa aaaggaactg atccgagttg tacggtcgaa 1530361 agaaggcgaa atctcagtag acccgaccgg aaaaaagaat gggcggggtg cttatttaac 1530421 gctggataaa gagtgcatct tagcagcaaa aaagaaaaac actttgcaaa atcaatttca 1530481 atcacaaatc gatgaccaga ttttcgatga attgctggaa ctggcggaaa aggtgaaaaa 1530541 ataaaatgtc tggaatggaa tggtttccct tgctgggtct ggccaatcga gctcgtaagg 1530601 tcgtgtcagg cgaagacttg gtaataaaag aaatcaggaa tgcgcgtgca aagcttgtcc 1530661 tgcttacaga ggatgcatca tctaacacag caaaaaaagt aactgacaag tgcaattatt 1530721 ataaagtccc ttataaaaaa gtcgagagtc gcgcggttct tggacgctct atcggtaaag 1530781 aagcccgtgt cgttgtcgcc gtcactgacc aaggttttgc gaataagctg atcagcttgc 1530841 tcgattaata tttttggggg tgaacgaatg gctaaaatga gagtatacga atatgcaaaa 1530901 gcgttaaatg tttcaagtaa ggaaattttg accgcactga agaacatgga tttagaagtg 1530961 aataatcaca tggccatgct tgaagaaaag gccattaaaa agctagatgc caaatataaa 1531021 aaaggcggcg cagctgctaa atctcaaaag ccagcagaaa cgaacaaaaa caaacagcca 1531081 caaggggtta atcagcaatc agctggaaat caaccaaata aaattcgaga cggaaagaag 1531141 aatgacgtgc agaataatca atttaacaaa aacaagaaga ataacaacaa caaaaaaaat 1531201 aaacgcaaca acaacaataa taaaaaccaa catcagcaaa agcctgtaaa gccgaaaaaa 1531261 gagcttcctg agaaaattac attctctggc actttaacag ttggcgcact tgctgaagag 1531321 cttggcaaag agccttcaga actcattaaa aagctgatgc ttcttggcgt aatggcaacc 1531381 attaaccaag agcttgataa agacacaatc gaactcattg catcagaata tggtgttgaa 1531441 acagaagagg tcattgtgct tgaagaaaca gagctggaaa aatacgaaga gcctgataat 1531501 gaagaggatc ttgaaattcg tcctcctgtc gtgacaatca tgggccacgt tgaccatggg 1531561 aaaacaacgc ttcttgacag catccgtaaa acaaaggttg ttgaagggga agcaggcgga 1531621 atcactcagc atatcggcgc ttatcaaatt gaagagaacg gcaagaaaat cacgttcttg 1531681 gatacaccgg gccacgccgc atttacaaca atgcgcgcac gcggtgcaga agtaactgat 1531741 attacgattc ttgtcgtagc tgccgatgac ggtgtcatgc cgcaaacagt tgaagcgatt 1531801 aaccatgcaa aagcagcaga ggttccaatc atcgttgctg tgaataaaat agataaagaa 1531861 tccgcaaacc ctgaccgtgt aatgcaagaa ctgacggaat acggacttgt ccctgaagct 1531921 tggggcggag aaaccatttt tgtgccgctt tccgctttaa ctggaaaagg cattgatgag 1531981 ctcgttgaaa tgattttgct tgtcagtgag gtagaggaac tgaaagcgaa tccgaatcgt 1532041 caggcaaaag gaacggttat tgaagctgaa ctcgataaag gcagagggtc agtcgcgacg 1532101 ttgctcgtac agactggaac actgcatgtc ggtgatccga tcgtagtcgg caatacattt 1532161 ggccgtgtcc gtgcaatggt caacgacatt ggccgccgtg tgaaaactgc cggcccgtca 1532221 actccggttg aaattaccgg tttgaatgat gtccctcaag cgggagacca attccttgtc 1532281 tttaaggatg aaaaaacagc tcgttctgtc ggtgaagccc gtgcttcgaa acagcttgaa 1532341 gagcagcgca gcgataaagc gaagctcagt cttgatgatt tatttgagca aattaagcaa 1532401 ggtgatgtaa aagacatcaa cctcatcgta aaagctgacg ttcaaggatc tgctgaagct 1532461 ttaacggctg cacttcaaaa aattgaagta gaaggcgtta aagtgaaaat catccataca 1532521 ggcgttggtg cgattactga atcagacatt atcttggcat ctgcttccaa tgcaattgtt 1532581 atcgggttta atgtgagacc ggacggaaat gctaagagta cggctgaagc tgaaaatgta 1532641 gatattcgac ttcaccgtat catttacaaa gtaatcgacg agattgaagc tgccatgaaa 1532701 ggtatgcttg atcctgaata tgaagaaaaa gtaattggtc aagtagaagt acgccaaaca 1532761 ttcaaagtat ctaaaatcgg tacaattgcc ggcggatatg ttactgaagg aaccattacg 1532821 cgcgacagcg gcctccgttt aattcgtgac ggcgtcgtca tctttgaagg cgaagtagat 1532881 gttctgaaac gctttaaaga cgatgtgaaa gaagtttcac aaggctatga atgtggtatt 1532941 acaattaaga aatacaatga cattcgtgaa ggtgacatcc ttgaagcgtt tgtcatgcaa 1533001 gaaattgaaa gaacgtgatc ggatttgcgg agtgtgaatg catcatttat gatgcaggat 1533061 cgctaaaaga aaagcgtgcc gttctgaagc ggattttaac cagggttcaa aacaagttca 1533121 atgtttcgat ttcggagatt ggctatcagg acacctggca aagaaccagc ttcggaatcg 1533181 ccgctgtttc ttcctctcgc gttcaaacag aaaaagaact gcagcgcgtc ctagcgttta 1533241 tcgattcttt tcctgaaatt gaacggacga tcactaggac agagtggttt taacttagag 1533301 gtgattgaat tgagtatgag agcaaaccgt gtcggcgagc aaatgaaaaa agaactcggt 1533361 gatattatca gccgcaagct gaaagacccg agaattggtt ttctgacagt aacggatgta 1533421 cgtgtatcag gtgatttgca aattgcaaag gtgtatatct cggttctcgg tgacgagaaa 1533481 aaacgggaag aagcgctgaa agggctggca aaagcgaaag gatttatccg atccgaaatc 1533541 ggcagccgca tcagacttcg aaaaacgcct gaaattgaat ttgagttcga tgaatcaatc 1533601 gattacggga atcggatcga aacactgatt cacgaattac attcagagaa accatctgaa 1533661 taaaaaaaga gaggataggc gtatatcgtc tgtcctcttt cttcgtttat aagaaaaaaa 1533721 ctcaaaagaa ggagtgaaag gcaaatggtt aacggagttc tccttttaca taaacctgtt 1533781 ggcatgacat cgcacgactg tgtcatgaag atccgaaagc tgttaaaaac aaaaaaagta 1533841 ggacatacag gaacgctcga tccggaagta tcaggcgtgc ttccgatttg tgtaggaaga 1533901 gcgacaaaaa tagtcgaata cttaactgaa aaatctaaaa cgtatgatgc agaaataaca 1533961 ttgggctttt caaccacaac agaggatcaa accggagaaa cggtggaaac aaagcctgtc 1534021 aatcacgaca ttgataaagc ggatgtagaa aaggttttaa acagtttaaa ggggaaacaa 1534081 gaacaaattc cgcccatgta ttccgctgta aaagtaaacg gcaaaaaatt atacgaatac 1534141 gcaagagcag ggattgaagt agaacgtccg aaacgtatga taaccattga agacattgcc 1534201 ctgacaacag agattaaaca tcatggagaa accgcaagct tccggtttac agtgacttgc 1534261 tccaaaggga cctatgtaag gacgctggcg gtcatgatcg gagaaaagct cggatatccg 1534321 gcccatatgt ctcatttaat ccgtacggca tccggagatt tttctctcga cgaatgcttt 1534381 acttttgatg aactcgaagc acaggcccaa tccggaaccg tggaagagca tacagttcct 1534441 attgaacgtg cgctcaatca tttgccgaaa tggatcataa gtgatacatt agctaagaaa 1534501 gtagaaaatg gggctttgct tgagacgccc gagcagtttt ctgaaatgac aagtggagac 1534561 cgtattgccg tctttactga atccggaacc tgcttggcga tctatttccc tcatcctgca 1534621 aaaaaagggc tgttaaagcc ggcaaaagta ttgatgcaaa aaagcgaaca atagaaaaaa 1534681 ggtgaccgtt ctgtgaagac gatacatatt acacatcctc atcatttaat aaaagaggag 1534741 caggcaaaat cagtgatggc gttaggttat tttgacggcg ttcatctcgg gcatcaaaag 1534801 gtaatcggca cagcgaagca aatagccgaa gaaaaaggtc tgacattagc tgtgatgacc 1534861 tttcatcccc atccttctca cgtgttgggc agagataagg aaccaaagga tctgattacg 1534921 cctcttgaag acaaaataaa ccaaattgaa caattaggca cagaagttct gtatgtcgtt 1534981 aaatttaatg aagtgtttgc ttctctttct cctaagcagt ttatagacca gtatattatc 1535041 ggccttaatg tgcagcacgc agtggcaggc tttgacttta cgtacggcaa atacggcaag 1535101 ggaacaatga agaccatgcc ggatgattta gacggaaaag ctgggtgcac aatggtagaa 1535161 aaattaacgg agcaggataa aaaaatcagt tcttcgtata tccgtaccgc gcttcaaaac 1535221 ggagatgttg aattggcgaa tgtcttgctt ggacaacctt attttattaa aggaattgtc 1535281 attcatggtg ataaaagagg gcggaccatc gggtttccga cagcgaatgt cggtttaaat 1535341 aacagctata tcgttccgcc cacaggtgta tatgccgtaa aagcggaagt gaacggcgaa 1535401 gtttacaatg gcgtttgcaa tattggctat aagccaacgt tttatgaaaa gcgccctgaa 1535461 cagccttcca tcgaggtcaa tctgtttgat ttcaatcaag aggtatatgg agccgctata 1535521 aaaatcgaat ggtacaaacg gattcggagc gagcggaaat tcaatggcat caaagaatta 1535581 actgagcaaa ttgagaaaga taagcaggaa gccatccgtt atttcagcaa tttgcggaaa 1535641 taacttgcaa cgcacgcaaa ttttattcta aaatatttgc atataggcac gatttttagt 1535701 atgatagttt tcgtagtctt aaaaccattg cttggcaatc cgaagtcacc gacggttgct 1535761 aggtaactgg ggctaaatat gatttggagg tgaaacagga tggcaattac tcaagagcgt 1535821 aaaaaccaac tcatcaatga gttcaaaaca cacgaatctg atactggatc tccagaagtt 1535881 cagatcgcta tcctaactga ctcaattaac aacttgaacg agcatttacg tactcacaag 1535941 aaagaccacc actcacgtcg cggtcttctt aaaatggtag gtaagcgtcg taatcttctt 1536001 acgtatctgc gtaataaaga cgtaactcgt taccgtgagt taattaacaa actaggctta 1536061 cgtcgataat cgtaaaaagc gggaggattc ccgctttttt atcgtattaa agcgaaattt 1536121 cttataacaa atcattgaaa tccttttaca tactactttg acattgatat gttcaattca 1536181 tttcgttcat aataggagta attgattatt tcacacaacg aagagaggag ttcgtaattg 1536241 tatgggacaa gaaaaacatg tctttaccat agattgggcc ggaagaacgc ttaccgttga 1536301 aaccggccag cttgccaaac aggcaaatgg tgctgtgatg atccgctacg gtgatacagc 1536361 agtacttagt acagcaaccg cttcaaaaga acctaaaccg cttgatttct tccctcttac 1536421 tgtaaactat gaagaaagat tatatgcggt agggaaaatt ccgggcggat ttattaaaag 1536481 agaaggacgt ccaagtgaaa aagcggttct tgccagccgt ttaattgacc gtccgatccg 1536541 tcctttgttt gccgatggat tccgtaatga agttcaagtc atcagcattg tcatgagtgt 1536601 tgaccaaaac tgctcttcag aaatggctgc catgttcggt tcatctcttg cactttctgt 1536661 atcggatatt ccgtttgaag gaccgattgc aggggttact gtcggacgca ttgatgatca 1536721 atttatcatt aacccgacag tcgatcagct tgaaaaaagc gatatcaatc ttgtcgttgc 1536781 cggcacgaaa gatgcgatta acatggtaga agcgggagcg gacgaagttc ctgaggaaat 1536841 catgcttgag gccattatgt tcggccatga agagattaaa cgcctgattg cattccaaga 1536901 agaaattgtt gcagcagtcg gcaaagagaa atctgaaatt aagctctttg aaattgatga 1536961 agagcttaat gaaaaagtaa aagctttggc agaagaggat ctgctgaaag ccatccaagt 1537021 tcatgaaaag catgcccgtg aagatgccat taacgaagtg aagaacgcag ttgtggcaaa 1537081 attcgaggat gaagaacatg atgaagacac aatcaagcaa gtgaagcaga ttttatccaa 1537141 gcttgtgaaa aatgaagttc gccgcctgat tactgaagag aaagtaagac cggacggccg 1537201 cggtgtcgat caaatccgtc cgctctcttc agaggttggc ctcttgccaa gaacgcacgg 1537261 ttcaggtcta tttacaaggg gacaaactca ggccctcagc gtatgtacgc taggtgctct 1537321 gggagatgtg caaatccttg acggcttagg tgtcgaagag tcgaaacggt ttatgcatca 1537381 ttacaacttc ccgcaattca gcgttgggga aacaggaccg atgcgcggac cgggacgtcg 1537441 tgaaatcgga cacggagcac tgggtgagcg tgcgcttgag ccagttattc cgtctgaaaa 1537501 agacttccct tatactgtcc gtcttgtttc agaagtgctt gaatcaaacg gttctacatc 1537561 tcaagcaagc atttgcgcaa gcacacttgc aatgatggat gccggtgtac cgattaaagc 1537621 gccagttgct ggtattgcga tgggtcttgt caaatcaggc gaacattaca ctgtcttgac 1537681 tgacatccaa ggcatggaag acgcgctcgg agatatggac tttaaagtag cgggaactga 1537741 aaaaggcgta acggccctgc aaatggacat taaaattgaa ggcctttcca gagagattct 1537801 tgaagaagcg cttcagcagg cgaaaaaggg cagaatggaa atcctcaaca gcatgcttgc 1537861 aacattaagc gaatcaagaa aagagctttc tcgatatgcg cctaagatct taacaatgac 1537921 cattaatcct gataaaatcc gcgatgtcat cggaccaagc gggaaacaaa tcaataagat 1537981 catcgaagaa accggtgtta aaattgatat tgagcaggac ggcacaatct ttatttcctc 1538041 tacagatgaa agcggcaacc aaaaagcgaa aaaaatcatc gaagaccttg tgagagaggt 1538101 tgaagtcggc caactttacc taggtaaagt gaaacggatt gaaaaattcg gggctttcgt 1538161 tgaaattttc agcggaaaag acggtttggt gcacatttca gagcttgcgc ttgaacgcgt 1538221 agggaaagtt gaagatgttg tgaaaatcgg agacgagatt cttgtcaaag tcactgaaat 1538281 tgataaacaa ggacgagtga atttatcccg caaagcggtg ctccgtgaag agaaagaaaa 1538341 agaagaacaa caatcttaaa tgaaaacata aaaggagcct gggagacccg gcttctttat 1538401 tttgaagctt ttcaaaagca ggcgggttct accttgtcct tctccttcat aatgtgaggt 1538461 gaggggggga cagaacatgt acaaaaaatt tgtaccgttt gccgtttttt tatttctttt 1538521 ttttgtctca tttgagatga tggaaaatcc gcatgcactt gattatatag gggcaatgaa 1538581 aaaagatacg gtgactgtca cggcgtcaaa agacccgtta tatgaagaat tgcttcaaaa 1538641 agcgccggag tacgaagtta agccccagaa tgcaagaatt gataaagtgt ggaaaagcat 1538701 tccaggctac aatggattaa aggtcaatat tgaacaatca tataaaaaaa tgaaacagca 1538761 tggtaagttt cgggaaaaag atttggtgta cagtcaagta aaaccaagtg ttcatcttga 1538821 gtcacttcag cctgagccta tttataaagg aaatcctgac aaaccgatgg tggctttttt 1538881 aatcaatgtg gcatggggaa atgagtattt ggaaaaaatg cttcctattc tgcaaaagca 1538941 ccaggttaaa gctacgttct ttttagaagg caattgggtg agaaacaatg tacagctcgc 1539001 taagaagatt gcaaaagacg gacatgaaat cggaaatcat tcatacaatc atccggatat 1539061 gagcaaactg actacaggaa gaatttccga gcagctcgac aagactaatg aacaaataga 1539121 acaaacgatc ggcgttaagc caaagtggtt cgctccgcca agcggaagtt tcagaaaagc 1539181 ggttatcgac attgcagcag agaaacagat gggaacagtc atgtggacag ttgatacaat 1539241 cgattggcaa aagccggctc cgtctgtact tcagacgaga gtgttaagca agatacataa 1539301 tggtgccatg attttaatgc atccgactga ccctacggcg gaaagtcttg aagcgctgat 1539361 tacacagata aaagacaaag gatatgcgct tggaacagtc actgaactaa tggatgaaac 1539421 aagactattg aagtaacaga tgaaggcagc ttgtctttga ataggaggaa caaatttgat 1539481 taaacgatat acgtgtcaaa atggtgtaag aattgtgctg gaaaataacc cgacagtccg 1539541 ttctgttgcg atcggcgtat ggatcggcac aggttcgaga catgaaacgc cggagataaa 1539601 cggaatttct cactttttag agcacatgtt ctttaaaggg acgagcacaa aatctgcacg 1539661 cgagatagca gaatcttttg atcgtattgg cggccaggtc aatgcgttta cttcaaagga 1539721 atatacctgc tactatgcaa aggtgcttga cgagcatgcg aattacgcgc tggacgtatt 1539781 agcagatatg ttctttcatt caacgtttga tgaaaacgag ctgaaaaaag agaaaaatgt 1539841 agtatatgaa gaaattaaaa tgtatgaaga tgcgccggac gacattgtac atgatttatt 1539901 gagcaaagcc acttacggca atcattcttt aggctaccca attttaggaa cggaagaaac 1539961 gcttgcttcc tttaacggtg actctctcag acaatacatg catgattatt atacgccgga 1540021 ccgagtggtg atttcggtag cgggcaatat atctgacagt tttatcaaag atgtagaaaa 1540081 atggttcggg tcatacgagg cgaaaggcaa agcgacaggc cttgagaagc ctgagttcca 1540141 cacggaaaaa ctgacgagaa aaaaagaaac agagcaggct catttgtgcc ttggatttaa 1540201 aggcttagag gttggccatg aacgtattta tgatttaatc gtcctcaaca atgtgctcgg 1540261 aggcagcatg agcagccggc tgttccaaga tgtgcgtgaa gataaaggac ttgcttattc 1540321 tgtttacagc tatcacagct catatgagga cagcggaatg ctaacgattt acggcggaac 1540381 gggtgcaaat cagcttcagc agctgtcgga aacaattcaa gaaaccctgg ccacattaaa 1540441 acgtgacggc attacctcga aagaactgga aaacagcaaa gagcaaatga agggaagctt 1540501 aatgctgagc ttagaaagca caaacagcaa aatgagccga aacggaaaaa atgaactgct 1540561 gctcggcaaa cataaaacat tagatgaaat tatcaatgaa ttaaacgccg tgaacttaga 1540621 gcgtgttaat ggccttgcca gacaattgtt taccgaagac tatgcattag cacttatcag 1540681 cccttccggc aatatgccgt cttaaaaagg aaagcctgcc ccataatgga gcaggcattt 1540741 tttaatccct ttcatcatac atagtacaag ggggtgacag acatgcggct cagtgaatta 1540801 tcgggaaagg aaattgtaga catcaaaaga gctgaacggc tcggagtgct cggccagacc 1540861 gatttggaaa tcaatgaaca ggatggacag attacagcac tcctcattcc cacagttaag 1540921 tggtttggtt tgagaaagca aggtcatgac attcgtgtcc catggcacca tattcaaaag 1540981 atcggttcag atatgattat attagatgta cctgaggaaa tgcctcctcg acaagagtaa 1541041 atagcccaat tgactgtgaa gcgggctcta aagaaaacat ctgaaacatc ggctgccgga 1541101 gccgatgttt ttttatatgg aaaaagcgca tcttttatat tcaccggtat ttccttttga 1541161 tcataagatg aaggggagct taacaactag agatccagta tatacaaaga aggtgaacgt 1541221 ttagaatgtt aaccggattg aaaattgcag ttatcggcgg tgacgcaaga cagctcgaaa 1541281 ttataagaaa gctcactgaa cagcaggctg acatctatct tgtcggtttt gaccaattgg 1541341 atcacggttt taccggggca gtaaaatgca atattgatga aattcctttt cagcaaatag 1541401 acagcatcat tcttccagta tccgcgacaa caggagaagg tgtcgtatcg actgtatttt 1541461 cgaatgaaga agttgtgtta aaacaggacc atcttgacag aacgcctgca cattgtgtca 1541521 ttttctcagg aatttctaac gcctatttag aaaacattgc agctcaggca aaaagaaaac 1541581 ttgttaagct gtttgagcgg gatgacattg cgatatacaa ctctattccg acagtagaag 1541641 gaacgatcat gctggctatt cagcacacgg attatacgat acacggatca caggtggccg 1541701 ttctcggtct ggggcgcacc gggatgacga ttgcccgtac atttgccgcg ctcggggcga 1541761 atgtaaaagt gggggcaaga agttcagcgc atctggcacg tatcactgaa atggggctcg 1541821 ttccttttca taccgatgag ctgaaagagc atgtaaaaga tatagatatt tgcattaata 1541881 ccataccgag tatgatttta aatcaaacgg tactttctag catgacacca aaaaccttaa 1541941 tattggatct ggcctcacgt cccgggggaa cggattttaa atatgccgag aaacaaggga 1542001 ttaaagcact tcttgctccc gggcttccag ggattgtcgc tcctaaaaca gctgggcaaa 1542061 tccttgcaaa cgtcttgagc aagcttttgg ctgaaataca agctgaggag gggaaataag 1542121 gatgtcgtca ttaaaaggaa aaagaatcgg gtttgggctg accgggtcgc attgcacata 1542181 tgaagcggtt ttcccgcaaa ttgaggagtt ggtcaacgaa ggagctgaag tccgtccggt 1542241 tgtcacattt aatgtaaaat ctacaaatac ccgatttgga gagggcgcag aatgggttaa 1542301 aaaaattgaa gacctgactg gatatgaggc cattgattcg attgtaaagg cagaacctct 1542361 tgggccgaag ctgccccttg actgcatggt cattgcgcct ttaacaggca attcaatgag 1542421 caagctggca aatgccatga cggacagccc ggtgctgatg gcggcaaaag cgacaatccg 1542481 gaacaatcgg cctgtcgttc tgggtatctc gacaaatgat gctcttggtt taaacggaac 1542541 aaatttaatg aggctcatgt caacaaaaaa tatctttttt attccattcg ggcaagatga 1542601 tccatttaaa aaaccgaatt caatggtagc caaaatggat ctgcttccgc aaacgattga 1542661 aaaggcactc atgcaccagc agcttcagcc gattctagtt gagaattatc agggaaatga 1542721 ctaaatttac agaaaatctt tcccaaacta aaaaattcgg tcatcacccg catattctat 1542781 ggtaaaataa aacgtaaaat catagtcaaa tcaattcaat gaagctgatt ggcggaagga 1542841 gttttacaga tgggaagagg tttacacgta gctgttgtcg gagcgacagg ggctgtggga 1542901 caacaaatgc ttaaaacact tgaagacaga aactttgaaa tggacacact tacattgcta 1542961 tcttcaaaac gctctgcggg gacaaaagtc acgtttaaag gccaagagct gactgttcag 1543021 gaagcttctc ctgagagctt tgaaggggta aatattgctt tgttcagcgc cggcggaagc 1543081 gtatcacaag cattggcacc agaagctgta aaacgcggcg ctattgttat agataatacg 1543141 agtgcgttcc gcatggatga aaatacaccg cttgttgtgc cagaagtgaa tgaggcagac 1543201 ttgcatgaac acaacggcat tattgccaat ccaaactgct ctacaatcca aatggttgcg 1543261 gcacttgaac cgatccgcaa agcatatggc ttaaacaagg tcatcgtatc aacttaccag 1543321 gcagtatcag gagcgggtaa tgaagctgta aaagagcttt acagccaaac acaggcgatt 1543381 ttaaataaag aagaaataga gcctgagatc atgcctgtaa aaggtgacaa aaaacactat 1543441 caaatcgcct tcaacgcgat tccgcaaatc gataaattcc aagataacgg ctatacgttt 1543501 gaggaaatga aaatgataaa tgaaacgaaa aaaatcatgc acatgcctga ccttcaagta 1543561 gcggctacat gtgtgagact gccaatccaa actgggcact cagagtccgt ctacatcgaa 1543621 atagaccgtg atgacgctac agttgaagat attaaaaatc tattgaaaga agctccgggc 1543681 gtgacacttc aggatgatcc aagccagcag ctttatccga tgcctgctga tgctgtcggc 1543741 aaaaacgatg tgtttgtagg ccgcatccgc aaagacttgg acagagcaaa cggttttcat 1543801 ttatgggttg tttctgataa cctattaaaa ggcgcggcat ggaactctgt tcaaattgca 1543861 gaaagcctga aaaaactaaa cctcgtataa aagagagaat tttctaaaga cgaatagaag 1543921 agagtaaggc gctatcagcc tgctctcttc tgttacgtcc gaataatttg gagtgaaaac 1543981 agtgaagata attgttcaaa agttcggcgg aacatcagta aaagatgata aaggccgcaa 1544041 actggcttta gggcatatta aagaagcaat cagtgaagga tataaggttg tcgttgtcgt 1544101 ttcagcgatg ggccgaaaag gggacccgta tgcaacagat tctttgctcg ggctgcttta 1544161 cggcgatcag tcagcgattt ctcctaggga gcaggatttg cttttatctt gcggagagac 1544221 tatttcctct gtcgtcttta caagcatgct gcttgataac ggtgtgaaag cagctgcgct 1544281 gacaggggct caggctggct ttttaacgaa tgatcagcat actaatgcga aaatcattga 1544341 aatgaaaccg gagcgtttat tcagtgtgct cgccaatcat gatgcggtag tcgtcgcagg 1544401 cttccagggc gcaactgaaa agggtgatac aacaacaatc ggcagagggg gcagcgatac 1544461 gtctgcagcc gcactcggag cagctgttga tgcggaatac atcgatattt tcaccgatgt 1544521 agaaggcgtg atgactgctg acccaagagt ggtagaaaat gcaaaaccgc ttcctgttgt 1544581 gacgtatacg gaaatctgca acctggcgta tcagggggcc aaggtcattt ctccgcgtgc 1544641 tgtggaaatc gcaatgcagg ccaaggttcc gatccgcgtc cgttcgactt attcgaatga 1544701 taaaggcaca ttggtgacat cacatcactc ttccaaggtc ggcagtgatg tttttgaaag 1544761 gctgattacg ggaatcgccc atgtcaaaga tgtcacgcag ttcaaagtgc ctgcgaaaat 1544821 cggccagtat aacgttcaga ctgaagtgtt caaggctatg gcaaacgctg gaatcagtgt 1544881 cgatttcttt aacattacac ctagtgaaat cgtctatacg gtagccggaa ataaaacaga 1544941 aacagctcag cgtattttaa tggatatggg ctatgatcca atggtgacga gaaactgcgc 1545001 gaaggtatcg gcggtcggcg cgggcattat gggtgttccc ggtgttacgt ccaaaattgt 1545061 atcggctctt tcagaaaaag aaattccgat ccttcagtcg gctgacagcc atacgacgat 1545121 atgggtgctc gtccatgaag cggatatggt tcctgctgta aacgctttgc atgaagtgtt 1545181 tgaactttcg aagtaaatgt gattgaatca tgatgaggtg aataaaatga atttcggaaa 1545241 tgtgtctaca gcgatgatta caccctttga caataaaggg aacgtagact ttcaaaaact 1545301 gtctacactg attgattact tgttgaaaaa cggaacggat tctttagtag tagcgggaac 1545361 aactggagaa tctccgaccc tttcaactga agaaaaaatt gcgctttttg aatatacggt 1545421 aaaagaagta aacggacggg tgcccgttat cgctggtact gggagcaaca acacgaaaga 1545481 ttccattaag ctgacaaaaa aagctgagga agcgggcgtg gacgctgtta tgcttgttac 1545541 cccgtattac aataaacctt ctcaagaagg aatgtaccag cattttaaag caattgcggc 1545601 agagacatct cttccggtta tgctctataa tgttcctggc cgtacggttg cttctcttgc 1545661 tcctgaaacg acgatccgtt tggcggcaga cattccgaat gtggttgcga ttaaagaagc 1545721 gagcggagac ctcgaagcga ttacaaaaat tattgctgaa acacctgaag acttctatgt 1545781 ctattcaggg gatgatgctc taacgcttcc aattctttca gttggaggta gaggagttgt 1545841 gtcagtggcg agccatattg caggcactga tatgcagcaa atgatcaaaa attatacgaa 1545901 tgggcaaaca gctaatgcgg cactgattca tcagaaactg ctgccgatta tgaaggaact 1545961 gtttaaagcg cctaatcctg ctccagtcaa aacagcgctt cagctgagag gtcttgatgt 1546021 cggttctgtg cgtctgcctc tagtcccatt aactgaggat gaacgtctga gcttaagcag 1546081 cacgatcagc gaactgtaag aaaatttcat acagtgaaac aaacgcggtc attctcacat 1546141 tcagctgagt ttgaccgttt cttttacata ttggttttcc ctaaaccttc tgctttatct 1546201 tgttttctaa atttactttc agttataata ggaacaagtg atgatggacg ggtatgagac 1546261 taggaggata tagattttga aaaagaaaaa tacagaaaac gttagaatta tcgcccttgg 1546321 cggtgtcgga gagattggga agaaccttta tgtcattgaa attgactcag acatatttgt 1546381 cgttgatgcc ggccttatgc atccagaaaa cgaaatgctc ggtattgatg tagtgattcc 1546441 tgacatatca tatttgattg aacgggctga ccgcgtcaag gcaatctttt taacgcacgg 1546501 gcacgatgaa aatatcggcg gcgtttttta cttattaaac aagctgtccg ttccagtgta 1546561 cggaacaaaa ctgacgcttg cactgttaag agagaaatta aaacaatacg gacataaccg 1546621 aaaaactgat ttaagagaaa ttcactccaa atctgtcatt acatttgaat caacaaaggt 1546681 atcgttcttt agaacgattc acagcattcc tgattctgta ggtgtgagct ttaaaacatc 1546741 acttggatct attgtatgca cgggagactt caaatttgac caaacacctg cacttaatca 1546801 gacgtgcgac attggcgaga tcgccaagat cggcaatagc ggcgtgctcg ctctgctttc 1546861 tgacagtgca aatgcggaac ggccgggtta caccccttcg gaagcggctg tcagcggaga 1546921 aatttcggat gcgctgtata attcacagaa ccgggtgatt attgctgttt tcgcatccaa 1546981 tattaaccgg attcagcaag tcattcatgc agcggctcaa aatggcagaa agattgccgt 1547041 agccggaaaa aatcttcaat ctgtcctgca gctggcgaga aagttaggat atattgaagc 1547101 agatgatgaa ttgtttattt ctgtacagga tgtcaaaaaa tatccgaagc gcgaagtggc 1547161 cattattaca gccggaagcc aaggtgaacc attagctgct ttgacaagaa tggcaaacaa 1547221 agctcacaaa cagctgaaca ttgaagaagg ggatacggtg gtcattgcgt caactccgat 1547281 tcccgggcag gaactcattt actctaaaac agtagatctt cttgcgagag ccggtgcaca 1547341 agtcatcttt gcccaaaagc gtgttcatgt atcaggccac ggctcacaag aagagttaaa 1547401 gctgatgatc aacctgctta aaccaaaata tttgattcct gtaaacggcg aatacagaat 1547461 gcaaaaagct cattcaaaaa tcgctgaaga aaccggcatg aagcgcagtg acatcttctt 1547521 aattgaaaaa ggcgacgtcg ttgaattccg cggccaaaac gtaaaaattg gggataaagt 1547581 tccttacggc aatattttaa ttgatggttt aggtgtcggt gatatcggca atatcgtatt 1547641 gagagaccgc cgcttgcttt cacaggacgg aattttaatc gttgtcatta cacttgataa 1547701 acaaaagaaa catcttgtat caggaccaga aattatcact cgcggctttg tttatgtaag 1547761 agagtctgaa ggtcttatcg tacaggctac tgagcttgta cggtccatcg tgacagaagc 1547821 gactgaaaca tcaaatgtcg aatggtcaac gctgaagcag gcaatgcggg atgctttgaa 1547881 ccaattcctt tatgaaaaaa cgaaacgtaa accgatgatc atcccaatta ttatggaagt 1547941 ataatgactg actaaagacc ggagctgctc cggtctttat tttttgtcct tcaagccggg 1548001 attgaatgaa gtatctttgt tcataataca aagagaaact cggaaaggat gaaagcgaga 1548061 tggatcatcg tatggaaaac acagaagaag agcgtcctga aaaaaatgat gcgaaggaca 1548121 gcattatgaa taaaatacag cagcttggtg aaacgacgct tccgcagctg ccccaagata 1548181 caaatattca ttgtctgacc attatcggac aaattgaagg ccatgttcag cttcctccgc 1548241 aaaacaaaac aacaaaatat gaacatgtca tcccgcagat tgtggcaatt gaacaaaatc 1548301 ccaaaattga aggcttgctg atcatattaa atactgtcgg aggagatgtt gaagctggtc 1548361 ttgccatagc ggaaatgctt gcatctttat cgaaaccgac cgtttctatc gtgcttggcg 1548421 gggggcattc aatcggcgtt ccgattgctg tatcctgtga ttacagctat atcgccgaaa 1548481 cagcaacgat gacgattcat ccagttaggc tcaccgggct ggtcatcggg gtgccgcaaa 1548541 cgtttgaata cctggataag atgcaagaaa gagttgttaa atttgtgaca agccattcca 1548601 atataaccga agagaagttt aaagagctaa tgttttcaaa aggaaactta acacgcgata 1548661 tcggaacaaa tgtagtcggt aaggatgcag ttaaatacgg attgatcgat cacgcaggcg 1548721 gtgtcggaca ggcaatcaat aaactgaatg agctcatcga tgaagcaagg aaagaagaag 1548781 gacggatgat tcaatgattc tttataccgt gatgcctcag gaaattgtgt ttgcagaaca 1548841 gaaccaagag acaagcgcac atgagcaaat tgaatataaa ggtgtaccgc ttctagtcga 1548901 aatgaaaggg aatgaagcgg aagtcattca aatcatgagc accaatccaa tgcattttct 1548961 gcatccggac atttcaccgg gacaaaagct gaaattaaac gtataagaat ccaacccttt 1549021 tttaagggca aaatatgcta taatagggga atcctacaga aaaaacgcag cctgtaaacg 1549081 gctgctttct tcattatgta tgaacttaca ttttttaacg cagtaaggtg atgagtgtgg 1549141 caaagaaaaa acgaaaatca agaaaaaaac aggcgaaaca gctcaatata aaatacgagc 1549201 tcaacggatt gctgtgtata gccatttcaa ttatcgcaat cttgcagctg ggggtagtcg 1549261 ggcaaacgtt tatctatttg ttccgctttt ttgctggaga gtggtttatt ttatgcttgt 1549321 taggtttatt ggtgttagga gtctcactgt tttggaagaa aaaaacccca agccttttaa 1549381 cgagacgaaa ggccgggttg tactgtatta tcgcaagcat attgctgctt tctcacgtgc 1549441 agctatttaa aaatttgacg cacaaagggt ctattgagtc tgcaagcgtg gtgcgcaata 1549501 cgtgggaatt gtttttaatg gacatgaatg gcagctctgc ttcacctgat ttaggcggag 1549561 ggatgatcgg tgcgctgctg tttgcggctt cacacttttt gtttgcgtcg actggttctc 1549621 agatcatggc aattgtcatg attttgatcg gaatgatttt agtaacagga cgctcgctgc 1549681 aagaaacgct aaaaaagtgg atgagcccga ttggacgttt tataaaagaa caatggttag 1549741 catttattga tgacatgaaa tccttcaaat caaatatgca gtcatcgaaa aaaacgaaag 1549801 cgccgagcaa aaaacaaaaa ccggcccgca aaaaacagca aatggaaccg gagcctcctg 1549861 atgaagaggg ggattatgaa acagtatcgc ctcttattca ttcagagccg attatctcaa 1549921 gcttttctga tcgtaatgaa gaggaagagt ctccagttat agaaaagcgc gccgaacctg 1549981 tgtcgaagcc gcttcaggac atccaaccgg agacaggtga tcaggaaact gtttctgctc 1550041 ctcctatgac ctttacagag ctcgaaaata aggattacga gatgccgtca ctggatttgc 1550101 tggcagatcc gaagcatacc ggccagcagg ctgataaaaa gaatatttat gaaaatgcga 1550161 gaaagcttga acgcacattc caaagctttg gcgtaaaggc gaaagtcaca caggttcatc 1550221 tcggaccggc cgtaacaaaa tatgaagtat atcctgatgt cggagtgaag gttagcaaaa 1550281 ttgtcaattt aagcgatgat ttagcgcttg cgcttgctgc gaaggatatc aggatcgaag 1550341 cgcctatacc aggcaaatca gcaatcggaa ttgaagttcc aaacgcagaa gtggcaatgg 1550401 tttcgctgaa agaagtgctg gagtctaaat tgaatgacag accggatgcg aagctgttaa 1550461 ttggactcgg ccgcaatatt tcaggtgaag ctgtattggc tgagttaaac aagatgcccc 1550521 accttttggt cgcaggcgca accggtagcg ggaaaagtgt ctgtgtcaac ggcattatta 1550581 caagtatttt aatgcgggcg aaaccgcatg aagtgaaaat gatgatgatc gatcctaaaa 1550641 tggtagagct aaatgtctac aacgggattc cgcatttgct tgctcctgtt gtaaccgatc 1550701 cgaaaaaagc gtcgcaggct ttgaaaaagg ttgtcaatga aatggagcgg cggtacgaat 1550761 tattttctca tacgggtaca agaaatattg aaggatacaa tgattatata aaacgcgcca 1550821 acaatgaaga aggagcgaaa cagccagagc tgccttatat tgttgtcatt gtggacgagc 1550881 tagccgatct catgatggtc gcttcatctg atgtggaaga ttcgattacg agattgtccc 1550941 aaatggcgcg ggctgccggc atccatctta ttattgcgac acagcggcca tcggtggatg 1551001 ttatcacagg ggtgatcaaa gcgaacattc cgtcacgaat cgcgttcagc gtatcttcac 1551061 agacggattc aaggaccatt cttgacatgg gtggcgctga gaagcttctt ggccgcggcg 1551121 atatgctgtt tttacctgta ggggctaaca aacctgtccg tgtgcaggga gcatttttgt 1551181 cggatgacga agtggagaag gtcgtcgacc atgtgattac tcagcagaaa gcgcaatatc 1551241 aagaagaaat gattcctgag gagacgacgg aaactcattc cgaggttact gatgaacttt 1551301 atgatgaagc tgttgaatta atcgtcggca tgcagacggc atctgtttca atgctgcaaa 1551361 gaagattcag aattggctat acgagagcgg cgcgcctgat tgacgcaatg gaggaacgcg 1551421 gtgttgtcgg accgtatgaa ggcagcaaac ctagggaagt attattatca aaagagaaat 1551481 atgatgagct ctcttcttaa tgaagggagt tccgctttct atagttgtca ataatgatat 1551541 tatgtaaact gatcaccttt ctatttattt tttcgacaaa acatgatata gttgtcccaa 1551601 ttgttcaata atttttatcg aaagtggttt acggagggga aacatgtcta caaaagctga 1551661 taatcggcac ttgtatttga aagtaattga acgaattaaa gaggatataa aaaatgggat 1551721 ctacactgag aaggaaaagc tgccttctga atttgagctt tccaaaaagc ttggtgtcag 1551781 cagagcgacg ctaagagaag ccttgcggat actggaagaa gagcatgtga ttatcagaag 1551841 gcatggtgta ggcacttttg tccattctaa gccgttattt ctttcgggta ttgaacagct 1551901 gaacagtgta accaagatga tagaacaggc gaatatgacc cctggcacga tttttctatc 1551961 atcacaagtg cttatgccgt ctgaagatga tacgaagaga tttcacttgg cagaagggca 1552021 agaacttttt taccttgaac gagtcaggac agctgacgga cagccgattg tgtattgtat 1552081 agacaaaatt ccgatgaata ttttgccgaa ttctttttct catcagcaag aatctatgtt 1552141 tgacctgcta gagaaaaatt caggctccgt aatcagctat gcagtaactg atatagaacc 1552201 gatcggctat cacgatacca tttctccagt gcttgaatgc gatccggaaa cagctctttt 1552261 gctgttaaaa caaacccatt acgatcagca cgataaaccg gtgctttatt ctttaaatta 1552321 ttttagagcg gataaattca gatttcatgt tttgcgtaaa cgattctaaa aacggacgcc 1552381 tgtatgtgtc tgttttttta tttgcactga ttcatgtttc tttgtacata ctttcattcc 1552441 ggttaacgca atatataagg gatgacaaga aagtgaatgg gtgaaaatgt tgagagagaa 1552501 aaatggaatg aaaaatatta ttgcattgtc ttctgtcccg cttgtgatga cactcgggaa 1552561 ctccatgctg attcctgttc ttccgatgat ggagaaaaag ctgtctgtga cttcatttca 1552621 agtatcttta atcattactg tatattcagt agtagcaatt atttgcattc cgattgccgg 1552681 atatttgtcg gatcgtttcg ggagaaaaaa aatattgctt ccatgcctcc tcattgcagg 1552741 attgggggga gccgtagctg cttttgcctc gacctatatg aaaaatcctt atgctatgat 1552801 cttggcgggg cgggttcttc aaggcattgg ttctgcaggt gccgctccga ttgtcatgcc 1552861 gtttatcggc gacctgttta aaggagacga tgaaaaggtc agcgcgggtc ttggcgatat 1552921 tgaaaccgcc aacacgtcag ggaaggtact gagtcccata cttggagcct tactggcttc 1552981 ttggtattgg tttgtaccgt tttggtttat tccgtttttc tgtttgatca gctttttgct 1553041 cgtattgttt ttggtggcca agcctgaaga agatgaagat gcgcctgctg tttctgagtt 1553101 tattaagagt gtgaagaaaa tttttaaaca ggatggtcgc tggctttata cggtcttcat 1553161 tatcgggtgt gtcattatgt ttttgttatt tggcgtatta ttttatttat cagatacgct 1553221 ggagaacaag tatgctattg acggagtagc taaaggcgga ttactggcaa tcccactttt 1553281 gtttttgtca accagttctt ttatagctgg caaaaagatc ggtaaagata aaggccgaat 1553341 gaaattttgc gttgttacag gaatgattct gttaaccctt tcgtttattg ccttgtggtg 1553401 gaaccacagt ttttattttt tatttgtctt tttaagcttt ggcgggattg ggattggaat 1553461 ggctcttcct gctttagatg cattgataac cgaagggatt gaaagtgaac aatgcggaac 1553521 catttcctcc ttttacaata gcatgcgctt tataggagta gctctcggtc cacctgtttt 1553581 tgctgcatta atgtctaatg caaactggat tattttcata ctctcggcgt tttgcagcat 1553641 cgtttcttta tttttagtgc tctttactgt agatgctaaa aaaagtgaag aagaaaaaaa 1553701 cttagggacg gtctagccag ccgtcttttt ttgcgctttc ttgcacagtt tacaactgta 1553761 cctatacagc atgcggaggt tattgtttcc ttataaatcc tacagttgct ataattacat 1553821 gaaagagtgt ttctgcggat gctgaaaatt ggtcataata catactaatt aagaaatgaa 1553881 cgaaggaggt tccatatgtc atatgttaat gaactcaaat caaagcacgg cggtttaacc 1553941 gcacacattg taaaaacaga aaaattcaaa accgtctcgc ttatttttaa gatgcttgcg 1554001 ccgctgacaa aggatcaagt caccaaaaga gcgcttctcc cgcatgtgct tcttcgcgga 1554061 acgaaaagcc atccgaaaac cgcaggattg cgttcatact tggatgagct gtacggcacg 1554121 tcagtatcgg ctgatcttac gaaaaaagga gagcggcatg tcattacgtt caggcttgaa 1554181 atcccgaatg aaaaatattt aaaagaccaa acgccgcttc tcgagaaagg gctccagctt 1554241 ctcgcagaac tcgtcttttc acctgctttg gagggagacg cttttcagtc acaatatgtg 1554301 gctcaagaaa aacggacgct taagcaaaga atccaagccg tctatgatga taaaatgcgt 1554361 tattcgaatt taaggctgat acaggaaatg tgcaaaaatg atccttacgc gcttcatgtc 1554421 aatggtgaaa tcgacgatgt cgatgacatt acggcagagc aattatacga aacataccaa 1554481 agcgctatcc aaaaagacca gcttgatcta tatgttgttg gcgacgtgga cagtaaccag 1554541 gtacaatcgg caattgataa gtatttcaaa acagaagagc gcactcttgg catgattgaa 1554601 aacaatcacg ctgatgaaaa agttcagcca aaagaagtaa ttgatgaaga ggatgtcaag 1554661 caaggaaaac tgaatatcgg ctaccgcacc agcatcactt atacagatca ggattatcct 1554721 gctttacaag tgtttaacgg attgttcggc ggattctctc attctaaact tttcattaat 1554781 gttcgggaaa aagccagtct tgcttactac gcggcttcgc gtatagaaag ttttaaaggc 1554841 ttgttaatgg tgatgtcagg cattgaagtg aaaaattttg aacaggcggt ttcgattatt 1554901 gctgagcaat tccaggcaat gaaaaatggc gatttcagtg agcaggatat agcacagaca 1554961 aaggccgtta ttcgaaatca agtgctggaa acgattgata cagcatacgg tttatctgag 1555021 tttttatatc agcaggccgc tgctcaagtc gagattccta tcgaagactt tcttgccaat 1555081 attgagaatg tcacaaaaga ggatatcatt aaagccggcg aaaagattca gcttgatacg 1555141 acttatttct taaaagggac ggagggtgca tcttgatcaa accaatcgaa tatgaacagc 1555201 ttcaggagac gctgtatcat gaaaaaatgt ccaacggcct tgatgtttac gttttgccga 1555261 aaaaaggctt caacaagaca tatgcggtct ttacaacaaa gtacggctcg atagataacc 1555321 ggtttgtccc tttaggtaaa aacgagatgg ttcacgtgcc ggacgggatt gctcactttc 1555381 ttgagcacaa gctgtttgag aaagcggacg gagacgtttt tcaagatttc agcaaacagg 1555441 gggcttctgc caatgcgttt acgtcattta caagaacggc ttaccttttc tcaagcacat 1555501 caaatgttga acgcaattta gagacgctta tcgatttcgt acaggaccca tattttactg 1555561 aaaaaacggt tgaaaaggaa aaagggatta tcgggcagga gattaatatg tacgacgata 1555621 accctgattg gaggctttac ttcggggtca ttgaaaacat gtacaaagag catcctgtca 1555681 gaattgacat agcgggaaca gtggaaagca tttcacatat tacaaaagac cttctttatg 1555741 aatgctatga aacgttttat cacccgagta acatgctcct tttcattgtc ggccctgtag 1555801 atcctgaagc gattatttct caggtaagag aaaaccaggg gaaaaagccg tatactgatc 1555861 agccggagat caaacgagaa gaagtgaaag agcaagaagc ggttttccga aaagaaaaag 1555921 agatcaaaat gaacgtgcag ggaccgaaat gccttgttgg gctgaaatcc aaaaatccgt 1555981 ttaaattagg caaagagctc ttaaagcatg aactttcaat gaacttattg cttgaagctc 1556041 tttttggcaa aagctctgcc cagtatgaat cactttatga aaaaggatat attgacgaaa 1556101 cgttcagctt tgattttact gctgaatatg ggttcggttt tgcggcgatc ggcggagata 1556161 cgcctgagcc tgatcaattg gctgaagaca tttcaagcat gcttttgcgc gccggtgaac 1556221 tgattactgc tgaaaagatt gaacttgcca gaaagaaaaa gatcggcaca ttcttaaaag 1556281 cgctgaattc ccctgaatac atcgccaatc aatttacccg ttatgcgttc ttggatatga 1556341 gcctgtttga tgttgtaacg gtactcgagc agattaccct cgaggatgtc cagaacgtaa 1556401 tacaagagga aatcgctgca gacagactga ctgtctgcaa ggttgttcct aaatcataaa 1556461 caaaacatcc ctccagtgtg aggggtgttt ttctgcggaa agaaggaaag aggatgaaca 1556521 aaacagcact aatcaccgga gcaagcggcg gcattggcaa aagcatcagc gaaacccttg 1556581 cagctagagg atacaatctg ctgctgcatt acaatacaaa tcaaaacgcg gcagcggagc 1556641 ttgctgaaaa actaagtcag atgtttggcg taaatgcgga gatattacaa gctgacctgt 1556701 ccgcgcaaga tggagcagat aagctgacaa gttcaattgt tcagccgatt gatgcgattg 1556761 ttttaaacag cggacgaagc cattttgggc tgattacgga tgtagataac gcaacggtcc 1556821 aggaaatggt tcagcttcat gtggcgagtc cgtatatgct gacgagaaac cttctgccag 1556881 gcatgattcg gaataaatcg ggagcgattg tggctgtcag ctcgatttgg ggagagactg 1556941 gagcatcctg tgaagtgttg tacagcatgg caaaaggagc tcagcattca tttgtaaaag 1557001 gattggctaa ggagctggcg ccaagcggaa tcagagtaaa cgccgtagcg ccgggtgcag 1557061 ttgatacaaa tatgatgaat caatttaccc cggctgaaaa agaagagatc gctgatgaga 1557121 ttccgatcgg ccggctggcc cggccgcaag aaattgcgga tgcaacagct tttctcctgt 1557181 ctgaaaaagc gtcatatatc accggccaaa ttctgtcggt gaatggcggc tggcactgct 1557241 gatccgaaaa tattcggtgt atagtttctt ttgcgaagga cacaataatc ttgtaacttc 1557301 acatgaaatg gaggaaacaa gcatgtcagt attagaaaac tgggatagct ggaaaaactt 1557361 ccttggcgac cgtctgaact atgcgcaaga taaaggtatg agccaggata cgattacaga 1557421 tcttgcgaca gaaatcggca gctacttggc taatgaagtg gaatctaaga acgagcagga 1557481 aaaagtgctg gcagatcttt ggagtgtagc atcaaaagat gaacagcacg ccattgccaa 1557541 tatgatggtt aagcttgttg aaaataacag cactcactag gaagagaggg gatttttcct 1557601 ctctttttta tgttttcctc atcacagcaa cattcttctt tctaattaga gaaaaatgct 1557661 ttatgataaa ggaaggtaaa attttgccac aatgaagggg gtatatcatt tggcaaagct 1557721 cgaatggtat tttgaatatg aaattcaagt gaaccgcccc ggactgctcg gggatatttc 1557781 atctcttctt gggatgcttt ctatcaacat cgtaacgata aacggcgtcg atctttccag 1557841 aaggggaatg ctcctcaggt gccgccatat agatcaaatt aaacgattag aatcaatctt 1557901 aaaaacgatg gaaacaatta aagtaacgaa gcttagagaa ccgaggcttc gcgaccgtct 1557961 tgccgtacgc cacggccgtt atattcaacg ggatgccgat gacaagaaaa cgttccgctt 1558021 tgaacgggac gagcttggct tattagtcga ttttatggcc gaattgttca aaaaagaagg 1558081 ccataaatta atcggaatca gaggtatgcc gcgtgtcggg aaaacggaat cgattgtagc 1558141 ctctagtgtg tgcgagcaaa aggtggctgt ttgtgtcatc aaccttgctg aagcagacga 1558201 taagaagcca gctgattgcc gatgaataca gcactgaaaa tgtctttatc gttgacggaa 1558261 ttgtgtcaac acgaagaggg tcagaacgcc atctccagct ggtccgagaa atcatgcggc 1558321 tgcctgcaac aaaagtggtg gagcatccgg acatattcgt tcaaaataca gagtatacac 1558381 tagatgactt tgattatatt attgaactga gaaatgaccc tgatgaggtt attacatatg 1558441 aacatgccga ggaaccccaa atgtttgatc aatccgggtt ttcaagcttt gatttttaaa 1558501 attggaaggt gtttgttgtg actgaactag gaatccggct caaagaagcc agagaggaaa 1558561 aagcaatgtc attggatgat ctccaagcgg caacaaagat tcaaaaaagg tatttaaccg 1558621 ccttggagga aggaaactat gacattattc cggggaagtt ttatgttcgg gcattcatca 1558681 agcaatatgc agaagccgtt gggcttgatg cggatcagct gtttgaggag cataaaaaag 1558741 atatccctaa tacgtatcat gatgatgtgt ctgaaaagat ctccggcatg aatcttcaaa 1558801 aggaaatgcc aaagccagca tctaaggcgc tggagctgct gccaacaata cttgttattc 1558861 tcggcgtgat tgtcgtgatt gccattgtgt acgcgatcat tcaatttgcc aatcacaaaa 1558921 acagtgatga tcacaatgcg gcatcagaaa aagcaattac gcaaagtgag agcaagtacg 1558981 aaatccctaa agattcaacg ctgaaagaga atcaaaataa cagctctgaa aaagagacag 1559041 acactaaaaa agaaacgaaa gaaaacgaag ataagaaaaa agaaaatgac agtgagaagc 1559101 tggagattaa agctgctggc actgaaggat cgttaacgac ttatgaagtg tccggcgctg 1559161 ataaaatcga gctggaactg aaggcatcag acagctcctg gattagagtg cgcgatgaaa 1559221 acagcagctc tttaaaagaa ggaacgctga aaaaagacga aacctataaa aaagacataa 1559281 ctgatcagaa acaagttgat atccgcaccg gatatgcacc taatctgaaa ataaaaatca 1559341 acggtaaggt tctttcatat gaacttgatc cgaaaaaagt gatggcacaa accataaaga 1559401 ttgtaaataa aaaggaagaa aagtcatctt aattaccaga tgacttttct tcacgtccga 1559461 gtatgaaatt ggaggggctt tatgtttaac ttaccaaata aaatcacact agctagaatc 1559521 gcattaatcc caatcttcat gattatcatg ctggcgccgt ttgactgggg caggctcgaa 1559581 gttggagacg aatccatccc ggtcgcacat ttggcggggg ccattctatt tattattgca 1559641 tctacaacag actgggtgga cgggtattat gcccgaaaat taaatctcgt aacaaacttc 1559701 gggaaatttc ttgatccgct tgcggacaaa ctgctcgtat ccgcagcgtt aattatcctt 1559761 gttcaatttg atctcgctcc agcttggatg gtcattgtga ttatcagcag ggagtttgcc 1559821 gtgacaggtt taaggcttgt cttagccgga acaggagaag tcgtagctgc taacatgctt 1559881 ggtaaaatca aaacctgggc acagattatt gcggtatctg cattgcttct tcataatctt 1559941 ccatttgaac ttgtgtcatt cccgtttgca gacttggcgc tgtgggtagc cgtcttcttt 1560001 actgtcgtct caggctggga atatttctct aaaaattggg aagcgttaaa aacatctaac 1560061 taagaaagaa ggacttcgtc atggaatttc caaaaaaagc agaaataatt gcagtcggtt 1560121 cagagttgct gcttggtcaa atcgccaata caaatgctca atttatcagc aaacagctcg 1560181 ctgaaatcgg ggtcaacgta ttttatcata cagcggtcgg agataacccg gagcggctga 1560241 agcaggtcat ccgcattgct gaagaacgct ctgacttcat tattttttca ggagggcttg 1560301 gacccacaaa agatgatctg acgaaagaaa cgattgcaaa tacgctggga cgtccgcttg 1560361 tgttaaatga tgaggcattc caatccattg aggactattt caaacgaaca aaacgcacga 1560421 tgtcacctaa taaccgaaaa caggcgcttg tgatcgaagg ctctgacgtg ctggcgaatc 1560481 actttggaat ggccccggga atgctcacag agcatgaatc gcgctattat atgcttcttc 1560541 ctggaccgcc gagcgaattg cgtccaatgt ttgaaaacga ggcaaagcct cttctgctga 1560601 aaaagatggg ttcaaatgaa aaaattgtgt caactgttct tcgctttttc ggtatcggtg 1560661 aatctcagct tgaagccgat ttggaagata ttattgatgc acaaaccaat ccgacaattg 1560721 cgcctttggc ggctgatgga gaggtgacgc tgcgtctgac agccaaacac gccgatgaaa 1560781 aggaaacaga gcgtctgtta aaagaaacag aggccgttat cttagagcgt gtcggtgaat 1560841 ttttctatgg ttacgatgat acttctcttg taaaagagct atctatagca tgtaaggaaa 1560901 aaggcataac aatttctgcg gcagaaagct ttaccggagg gctgttttct gaatggctga 1560961 cggatcatag cggtgcctca aaattatttg ccgggggcgt tgtttgctat acaaacgacg 1561021 tgaagcagaa tgtgcttggt gtcaagaagg aaacattaga tcgttttggg gcggtcagca 1561081 aggagtgcgc atccgaactg gctaagggtg ttcaaaaact cactggcagc gatatcggca 1561141 ttagctttac tggtgtagca ggacctgatg ctcaagaagg gcatgagcct gggcatgtgt 1561201 ttatcggcat ttccgcaaat ggtaaagaag aggttcacga gtttcacttt gcgggctcca 1561261 gaacggggat cagaaaacgc ggcgctaaat acggctgcca tttaatctta aagcttttag 1561321 agcaaaaata atattttcag cacattatcc tcctaagaaa acatgatttc tctgatacat 1561381 tatgatattt tgataggaat cacgccaaga aaaaatccga atatgcgttc gcttttttct 1561441 tggcaaatcc cttcaaacag ggtatagtat atgtagtggt aacataaagg aggaaaaaat 1561501 agaatgagtg atcgtcaggc agccttagat atggctctta aacaaataga aaaacagttc 1561561 ggcaaaggtt ccattatgaa actgggagaa aagacagata caagaatttc tactgtacca 1561621 agcggctccc tcgctcttga tacagcactg ggaattggcg gatatcctcg cggacggatt 1561681 attgaagtat acggtcctga aagctcaggt aaaacaactg tggcgcttca tgcgattgct 1561741 gaagttcagc agcagggcgg acaagccgcg tttatcgatg cggagcatgc gttagatccg 1561801 gtatacgcgc aaaagctcgg tgttaacatc gaagagcttt tactgtctca gcctgacaca 1561861 ggcgagcagg cgcttgaaat tgcggaagca ttggttcgaa gcggggcagt tgacattgtc 1561921 gttgtcgact ctgtagccgc tctcgttccg aaagcggaaa ttgaaggcga catgggagat 1561981 tcgcatgtcg gtttacaagc acgcttaatg tctcaagcgc ttcgtaagct ttcaggggcc 1562041 attaacaaat cgaagacaat cgcgattttc attaaccaaa ttcgtgaaaa agtcggtgtt 1562101 atgttcggga acccggaaac aacacctggc ggccgtgcgt tgaaattcta ttcttccgtg 1562161 cgtcttgaag tgcgccgtgc tgaacagctg aaacaaggca acgacgtaat ggggaacaaa 1562221 acgaaaatca aagtcgtgaa aaacaaggtg gctccgccgt tccgtacagc cgaggttgac 1562281 attatgtacg gagaaggcat ttcaaaagaa ggcgaaatca ttgatctagg aactgaactt 1562341 gatatcgtgc aaaaaagcgg ttcatggtac tcttatgaag aagagcgtct tggccaaggc 1562401 cgtgaaaatg caaaacaatt cctgaaagaa aataaagata tcatgctgat gatccaggag 1562461 caaattcgcg aacattacgg cttggataat aacggagtag tgcagcagca agctgaagag 1562521 acacaagaag aactcgaatt tgaagaataa aaataaaata agtttcaaat gatacaaaag 1562581 gctgagtgaa aaactcagct tttttgtatt ttgcaaaaaa atgataaaaa tattgctttt 1562641 tttgacaact tttttagggc tttattcgtc taacaaaacg tgtgcaaaat ggaatttatt 1562701 ttgggaggaa aaaatgaatg acaagcccaa cccgcagaag aactgcgaaa cgcagacgga 1562761 gaaaactaaa taaaagagga aaactgttgt ttggtctttt agcagtgatg gtttgcatta 1562821 cgatttggaa tgctcttcat cgaaatagtg aagaaaacga accatctcaa gaaactgcag 1562881 cggtttcaaa taccgatcag aaaaaagagg tcaaaaagaa aactgccaaa aaatcagagg 1562941 aacaaatcaa aacagtggat cgaaaccaaa aaatcagcaa ttatttaaaa gagatcggtt 1563001 tcagcggaac agccatgatt gtcagaaatg gagaaatcgt aacaaataaa ggttttggct 1563061 atgctgaccg taaacactac attcaaaata atccattgac atctttttat gtcggttcat 1563121 cacaaaaagc gctgattgca actgctattt tgcagcttga ggaaaagggg aaacttcaga 1563181 caagtgatcc ggtaagcacg tatttacctc attttcccaa cggacaaacg attactttga 1563241 agaatctgct tacacataca tcggggataa acggacatat tgaaggaaac ggcgccatta 1563301 ctccggacga tttaataaaa gatatagaac ttcagggaat caaacgtcag ccgggcgtat 1563361 gggactacaa ggattccaac tattctgttc ttgcttatat tattgctgaa gtaagcggtg 1563421 agccctatga acagtacata aagaatcata tttttaaacc tgcgggaatg acgcatgcag 1563481 gcttttacaa aacatatgaa aaagaacctt atcctgccgt cgggtataag atggagggca 1563541 gcaaaacagt tacaccgtat atacctgatt tatcccagct gtatggagcg ggtgatattt 1563601 atatgagcgc tatagatatg tacaaatttg accaagcgct gatagacgga aaactgtatt 1563661 cgcaaaaaag ctatgaaaag atgtttacgc cagggagcag ctccacatac ggcatgggat 1563721 tttatgttgc tcccggaagc tattcaaacc atggtgttat gccgggcttc aatatcttga 1563781 acagctttag caaatctggg caaaccattg ttattttgtt ctcaaacatt caaaataatg 1563841 ctaaattggg ccaagtgaac aataaaatat accagcttct aaatcaagaa tgattggcga 1563901 tcttcttttg gatgaattgc attcggcacg tgaaaagaag actggcctgc aaacgttaag 1563961 atggcaagct tgacaagtat ttccgacaca tttacaatga agttgtaaca tttgtttttt 1564021 taacatgatt gttaaaccat ttaaacttga caagggcgat gaacacactc attccctgtg 1564081 aaggttctgt atgttgagaa aactagacaa tgtacatgcc gacacttttt aagcaacaac 1564141 caagttcata gcaagaggag gtgaaagtat gaccccaatt atgatggttc tcatctccat 1564201 tttgctgatt ctactcggtt tagttgttgg ctactttgtt cgtaaaacca ttgccgaagc 1564261 gaaaattgcg ggcgcacgcg gtgcagccga gcaaattctt gaagatgcga agcgtgatgc 1564321 tgaagcactg aaaaaagaag ctctgcttga agcaaaggat gaaatccaca aacttcgaat 1564381 agatgctgaa caggaagttc gtgaaagacg aaatgagctt caaaaacaag aaaaccgttt 1564441 actccaaaag gaggaaaacc ttgatcgcaa acatgaggga attgataaac gggaagcgat 1564501 gttggagaag aaagatcatt ctctgaatga acgacaacaa catattgaag agatggaaag 1564561 caaagtggat gagatgattc gtatgcagca gtctgagttg gaacgaattt cgagtctgac 1564621 tcgtgacgaa gcgaaacaaa tcattcttga gcgggttgaa aacgagcttt cacatgacat 1564681 cgccatcatg acaaaagaaa ctgaaaaccg tgcgaaagaa gaggcggata agaaagcgaa 1564741 aaacattctt tcactcgcct tacagcgctg cgcagcggac cacgttgccg aaacaacggt 1564801 atcagttgtc aatcttccaa atgatgagat gaaaggacgt atcatcggac gggaagggcg 1564861 taacattcgt acgcttgaaa cgctgacagg aattgacctg attattgatg atacgcctga 1564921 agctgtcatt ctttccggat ttgatccgat cagacgtgag acagccagaa ttgctcttga 1564981 taaactcgtt caggatggcc gtattcatcc ggcacggatt gaagaaatgg ttgaaaaatc 1565041 tcgccgcgag gtcgatgact atattcgtga gatgggtgag caaacgacat ttgaggttgg 1565101 cgttcatggc ctccacccag atctcatcaa gatcctcggc cgcttaaagt tccgtacaag 1565161 ctacggtcaa aatgtgctta agcattccat ggaagtcgca ttcttggccg gtctaatggc 1565221 atcggagctt ggtgaagacg caaagcttgc taaacgtgcg ggtcttcttc acgacatcgg 1565281 gaaagcaatt gaccatgaag tagaaggaag ccacgttgag atcggggtag agcttgcgac 1565341 caaatataaa gagcacccag tcgtgattaa cagtattgca tcacaccacg gggacgagga 1565401 gccgacttcc attattgctg tactggtagc tgcagcagat gcgctttccg ctgcaagacc 1565461 tggcgcaaga agtgagacgc tcgagaatta tattcgaaga cttgaaaaac ttgaagaaat 1565521 ttctgagtcc tacgaaggtg ttgaaaaatc atttgccatt caggctggac gcgaagtgcg 1565581 aattatggtg aagccggatt caattaatga tcttgaggct catcgactgg cgcgagatat 1565641 ccgcaagcga attgaggacg agctcgatta tccaggtcat attaaggtga cagtaatcag 1565701 agagactcga gccgtagagt atgcaaaata aagtgatgcg ctaagcatca ctttattttt 1565761 ttgacggcaa ggaattttca agaagaaagg atttacaaaa tgagaatttt atttatcgga 1565821 gatgttgtcg gttcaccggg ccgtgacatg gtcaaagaat atgtaccaaa gctaaaaaca 1565881 aaatataagc ctcactttac cattattaat ggtgaaaacg ccgcacatgg aaaaggcctg 1565941 acggaaaaaa tttatcacag cttaatccag tccggcgcag atgcaatcac aatggggaac 1566001 cacacatggg acaaaaaaga aatatttgat tttatagatg acgttccgaa cttggttcgc 1566061 ccggcaaact ttcctgaagg aacaccgggg aaagggatca catatgtgaa agcaaacggc 1566121 aaagaactag cagtcattaa tttgcaggga cgtacgtttt tgccgccgct tgatgacccg 1566181 tttttaaaag cggatgaatt gatcgcagaa gctgcgaaaa gaacaccgta catttttatt 1566241 gactttcatg ccgaagcgac aagtgaaaag ctcgcacttg gctggtacac ggatggacgg 1566301 gcatcggctg tagtaggaac tcatacacac gtgcaaacag cggataaccg cattttgccg 1566361 aagggaacgg catatattac tgatgtggga atgactggcc cgtatgacgg tatactgggg 1566421 atggacagag agacgattat taagcgattc aaaacgaacc ttccagtccg gtttactgtc 1566481 gctgaaggaa aaacaacgct cagcggagtt gtcattgaca ttgacgatca aacgaaaaaa 1566541 gccgtgaaaa ttgagcgtat tttaatcaac gatgatcaca tgttctttga atagttgaac 1566601 atatggttat tttataaaaa tattaaaaag aaaagcagga atatagcaac tccttagtga 1566661 atatagtaaa aatggaaggt agcccgctat ttttgaaaag cattgtgggg atggcttttt 1566721 ggatagcaac atctaataat gattgttcta atgaacactc acttatccat tgtaaaacta 1566781 agggggagca gaaatggaaa tcttaaaagt ttcagcaaaa tcgagtccaa attcagtggc 1566841 aggtgcgctt gcaggcgtgt tgagagagcg aggagccgcc gagattcaag cgatcggagc 1566901 gggtgcatta aaccaggctg taaaagctgt ggcgattgcc aggggatttg tggcgccaag 1566961 cggcgttgat ttgatttgta ttccggcttt tacagatatt caaatcgatg gggaagaaag 1567021 aacagcgatt aaattaatcg tggagcctcg ctaaaaacaa ataaagcatt ctcaacctgt 1567081 ttgcgtaatg caaacaggtt gtttttcatt tattgtgata ttttctcccg atagtatttt 1567141 tagcacataa atgagcgaat atacaaaatc agaaatgagc taaaacgttt caaaaaaaat 1567201 ttccgcccat ttttcaagac agatactttt gtccttctgg aaaagacagt tctgtttacg 1567261 cttattccat atcatggtac aatccgaata taacaagaat ttttcaagga ggattgtaca 1567321 tgcagagtgg aaagatgaaa gctctaatga aaaaggacgg ggcgttcggt gctgtgctga 1567381 ctgaagttcc cattcctgag attgataaac atgaagtcct cataaaagtg aaagccgctt 1567441 ccatatgcgg cacggatgtc cacatttata attgggatca atgggcacgt cagagaatca 1567501 aaacacccta tgttttcggc catgagttca gcggcatcgt agagggcgtg ggagagaatg 1567561 tcagcagtgt aaaagtggga gagtatgtgt ctgcggaaac acacattgtc tgtggtgaat 1567621 gtgtcccttg cctaacagga aaatctcatg tgtgtaccaa tactgctata atcggagtgg 1567681 acacggcagg ctgttttgcg gagtatgtaa aagttccagc tgataacatt tggagaaatc 1567741 ccgctgatat ggacccgtcg attgcttcca ttcaagagcc tttaggaaat gcagttcata 1567801 ccgtactcga gagccagcct gcaggaggaa cgactgcagt cattggatgc ggaccgattg 1567861 gtcttatggc tgttgcggtt gcaaaagcag caggagcttc tcaggtgata gcgattgata 1567921 agaatgaata caggctgagg cttgcaaaac aaatgggagc gacttgtact gtttctattg 1567981 aaaaagaaga cccgctcaaa attgtaagcg ctttaacgag tggagaagga gcagatcttg 1568041 tttgtgagat gtcgggccat ccctcagcga ttgcccaagg tcttgcgatg gctgcgaatg 1568101 gcggaagatt tcatattctc agcttgccgg aacatccggt gacaattgat ttgacgaata 1568161 aagtggtatt taaagggctt accatccaag gaatcacagg aagaaaaatg ttttcaacat 1568221 ggcgccaggt gtctcagttg atcagttcaa acatgatcga tcttgcacct gttattaccc 1568281 atcagtttcc attagaggag tttgaaaaag gtttcgaact gatgagaagc gggcagtgcg 1568341 gaaaagtaat tttaattcca taaaggggga taaacatgac gaaggaattt gagtttttaa 1568401 aagcagagct taatagtatg aaagaaaacc atacatggca agacataaaa cagcttgaat 1568461 ctatgcaggg cccatctgtc acagtgaatc accaaaaagt cattcagcta tcttctaata 1568521 attacctcgg attcacttca catcctagac tcatcaacgc cgcacaggag gccgttcagc 1568581 agtatggagc cggcaccgga tcagtgagaa cgattgcggg tacatttaca atgcatcaag 1568641 agcttgagaa aaagctggca gcctttaaaa aaacggaggc ggcacttgta ttccaatcag 1568701 gcttcacaac aaaccaaggc gtactttcaa gtattctatc aaaagaggac attgtcatct 1568761 cagatgaatt gaaccatgcc tctattattg acggaattcg actgacaaag gcggataaaa 1568821 aggtgtatca gcacgtcaat atgagtgatt tagagcgggt gctgagaaag tcaatgaatt 1568881 atcggatgcg tctgattgtg acagacggcg tattttccat ggatggcaac atagctcctc 1568941 tgcctgatat tgtagagctc gctgagaaat atgacgcatt tgtgatggtg gatgacgccc 1569001 atgcatccgg agtacttggc gaaaacggca ggggaacggt gaatcacttc ggtcttgacg 1569061 gcagagtgca tattcaggtc ggaacattaa gcaaggcaat cggagtgctc ggcggctacg 1569121 ctgcaggttc aaaggtgctg atcgattatt tgcgccataa aggccgtcca tttttattca 1569181 gcacatctca tccgccggca gtcactgcag cttgtatgga agcgattgat gtcttgcttg 1569241 aagagccgga gcatatggag cgcttgtggg agaatactgc ctattttaaa gcaatgcttg 1569301 tgaaaatggg tctgactctc acgaagagtg aaacgccgat tcttcctatt ttaataggtg 1569361 atgaaggtgt ggcaaagcaa ttttcagatc agctcctttc tcgcggtgtt tttgcccaaa 1569421 gtatcgtttt cccgactgta gcaaagggaa aagccagaat tcgcacgatt ataacagcag 1569481 agcacaccaa agatgaactg gatcaggcgc ttgatgtcat cgaaaagacg gcaaaggagc 1569541 tccagctatt gtaacaagag gaagagttta ctcttcctct tttgattcct tattgattat 1569601 tattctcaat gagtgtacaa tgataggttg ccagttgtgc agagcttcaa taacctttat 1569661 actgaagggt ggaagtttgg tttgaaagga gaaaatatga catgaatgaa aaacaaaaat 1569721 tagagagcgg acaagttcat ccatcggaca aaaaatccga gaaggattac agcaagtact 1569781 ttgaagctgt ttacattccg ccttctttaa aagacgcgaa aaaacgaggc aaggaagccg 1569841 ttacttatca taatgacttt aaaatttctg aacaatttaa aggattggga gacggaagaa 1569901 agttctatat ccgtacgtac ggctgccaaa tgaatgaaca cgatacagag gttatggcag 1569961 ggatctttat ggcgctcggt tacgaagcga caaactctgt tgacgatgcc aatgtcattt 1570021 tgttaaatac atgtgcaatc cgtgaaaatg ctgaaaacaa ggtgtttggt gagctcgggc 1570081 acttaaaagc actgaaaaaa aacaatcccg atctgatttt aggcgtgtgc ggctgtatgt 1570141 cccaagagga atcagtcgtg aaccgtattt tgaaaaaaca tccgtttgtc gatatgattt 1570201 tcggaacgca taacattcat cgcctgccgg agcttttgtc agaagcatac ctttcaaaag 1570261 aaatggttgt agaagtttgg tctaaggaag gggacgttat tgaaaacctt ccaaaagtcc 1570321 gaaatggaaa aattaagggc tgggtcaata tcatgtacgg ctgtgacaaa ttctgtacgt 1570381 attgcattgt gccttacaca cgcggaaaag aaagaagccg ccgccctgag gatatcattc 1570441 aggaagtgag aaggctcgca agtgaaggct ataaggaaat tactctgtta ggccaaaacg 1570501 taaacgcgta tggaaaagac tttgaagata tgacgtacgg acttggtgat ttgatggatg 1570561 aactgagaaa aatcgatatc ccgagaatcc gttttacaac gagtcatccg cgcgactttg 1570621 acgaccgcct cattgaagtg ctggcaaaag gcggaaatct gcttgatcac attcatcttc 1570681 cggttcaatc aggaagctca gaagttctca agctgatggc ccgcaaatat gacagagagc 1570741 gttacatgga gctggtgcga aaaattaaag aagcaatgcc aaacgcttct ttgacaacgg 1570801 acattatcgt cggatttcca aatgaaacgg acgaacagtt tgaagaaacg ctttctctat 1570861 accgtgaagt ggagtttgac agcgcctata cgttcattta ctctccgcgt gaaggcactc 1570921 cggctgctaa gatgaaagat aatgtaccga tgcgtgtgaa aaaagaacgc ctgcagcgtc 1570981 taaacgcact ggtgaatgaa atttctgcta aaaaaatgaa ggaatacgaa ggcaaggttg 1571041 tcgaagtatt agttgagggt gaaagcaaaa ataaccctga tattcttgct ggctatactg 1571101 aaaaaagcaa gcttgtcaat ttcaaagggc cgaaggaagc catcggcaaa atcgtccgcg 1571161 tgaaaatcca gcaagcgaaa acatggtcgc ttgacggaga aatggtagga gaagcaatcg 1571221 aggtgaaatg agatgacgct ctactcaaaa aaagacattg tgcagcaggc tcgaaacctt 1571281 gcaaaaatga tttctgaaac agaagaggtt gattttttca aacgggctga agcgcaaatc 1571341 aatgagaatg acaaagtgtc cacaatcgtt aatcagatta aagccctgca aaagcaggct 1571401 gtcaatctga agcattatga aaagcatgaa gcgctcaaac aagtagaagc aaaaattgac 1571461 gcgctgcaag aagagcttga agagattcct gttatccagg aattcagaga ctcgcaaatg 1571521 gaagtaaatg acctactgca gctcgttgca cacaccattt ccaaccaagt cacaaatgaa 1571581 atcatcacat caaccggagg cgacctgctg aaaggggaaa ccggttcaaa ggtgaagcat 1571641 tcaaataaca gctgttctct ctaaacacgg tgcctttaca ggcccgtgtt tttttatcat 1571701 ttgtgcggtt aaaaatgaac taaataatct atgtaccaaa tgttcaattg gtttttctgt 1571761 gctcagccgc gtataaactt tatcgcactt ataagtaaag tttctaggca cccctgcata 1571821 caatggaaca gaaactttgt atttttatat tttatttata aaaatgcaca ctagacaaat 1571881 gcccagcata agataacacg aagaagaaca aggaggcatg ccggaatgtc tgaatacagg 1571941 gaaattatta cgaaggcagt agtagcgaaa ggccgaaaat tcacccaatg caccaacacc 1572001 atctcgcctg agaaaaaacc gagcagcatt ttgggtggtt ggattattaa ccacaagtat 1572061 gacgctgaaa aaattggaaa aacggtagaa attgaagggt attatgatat aaacgtatgg 1572121 tactcttacg cggacaacac aaagacagag gttgtcacag aacgggtaaa atatgtagat 1572181 gtcattaaac tcagatacag agacaataat tacttagatg atgagcatga agtgattgcc 1572241 aaagtgcttc agcagccaaa ctgccttgaa gtgaccattt cgccgaatgg aaataaaatc 1572301 gttgtgcagg cagaaagaga atttttggcg gaagtggtag gggaaacaaa ggtagttgtt 1572361 gaggtcaatc ctgactggga agaggatgac gaggaagatt gggaagatga gcttgatgaa 1572421 gagcttgaag acatcaaccc ggagttttta gtgggagatc ctgaagaata aaaaagggac 1572481 taggggagac agtaccccca agtctctttt ttatattgat atatcattct tttatcactt 1572541 tttgtttatg ttataatgaa ggttggaaaa tagaaacgtt gatacatagt gagggattaa 1572601 acaatggccg gttatacgcc tatgatacag caatatttaa aaataaaggc agagcaccag 1572661 gatgcctttt tattttttcg cctgggtgat ttttatgaaa tgttttttga ggacgccaaa 1572721 aaagcgtcac aagagctgga aattacgtta acgagcagag acggcggtgc ggctgaaaaa 1572781 ataccgatgt gcggtgtgcc gtatcattct gcttccgcgt atatcgaaca gcttattaaa 1572841 aaaggataca aagtggcgat ctgtgaacag acggaagatc cgaaagccgc aaagggcgtt 1572901 gtgaaaagag aagtagttca gctgattacg cccggaactg taatggacgg caaaggcatc 1572961 catgagtcgg aaaataattt tatcgcatct gtttcagcct gctcgaacgg atacggactt 1573021 gctctgtctg atttaacaac gggagaaaat ttggctgttt tgattgaacg gcttgaagac 1573081 gtcatatcag aaatttattc agtcggcgca cgggaaatcg tggtttcagg aagcttggat 1573141 gccgatacag tggcacagct gagagagcgg tgcggtgcaa cgatttcaat tgaagacgga 1573201 gaaacagacg aacacgtaac gatcattgag cacttaaata atgaagatat aacaaaaaca 1573261 tttctgcgct tatatacgta tttgaaaaga acccaaaagc gcagccttga tcatcttcag 1573321 cccgtgcagg tgtatgagct tgaggaagcg atgaaaattg acttgtactc aaagcgtaat 1573381 ctggagctga ccgaaacgat tcgttcgaaa aataaaaaag gctccctttt gtggctgctg 1573441 gatgaaacaa aaacggcaat gggaggccgg ctacttaaac agtggattga ccggccgctt 1573501 atcagagtca atcaaatcga agagcgccaa gaaatggtgg aaacattaat gtcccatttc 1573561 tttgaacggg aagatctgcg tgaacgttta aaagaagtat atgacttaga acgccttgcc 1573621 ggccgcgttg cattcggaaa tgtcaatgcc cgggatttga ttcagctgaa ggaatcgtta 1573681 aagcaagtgc ctggcatcaa acagctggtt gcttcactgg ctcatgacaa ggccaaggaa 1573741 cgtgcaaagc gcattgaccc ttgcggggat gtacttgaac tgctggaaga agcgctgtac 1573801 gaaaaccctc ctttatcggt aaaagaaggg aacctgatta aagatggtta taatcaaaag 1573861 cttgatgaat atcgtgatgc aagcagaaac ggaaaagact ggattgcccg cctggaacag 1573921 caggagcggg aatacacagg cattcgctct ttaaaggtcg gctttaataa agttttcggt 1573981 tattacattg aagtgacaaa agcaaacttg catttgcttg aggaagggcg ttatgagcgg 1574041 aagcagacgt taaccaatgc agagcgctac attacacctg aattaaaaga aaaagaagcg 1574101 ctcattttag aggcggaaaa taacatctgt gagctggagt acgagctgtt taccgagctg 1574161 cgcgagaaag tgaagcagta tattccgcgg ctgcagcagc ttgcaaaaca gatgagcgag 1574221 ctggacgcac tgcaatgctt tgcgacaatc agtgaaaatc gccactacac gaaaccagag 1574281 ttctctaaag atgaagtcga agtgattgaa ggcagacacc cggttgttga aaaagtcatg 1574341 gacagccagg aatatgtccc gaacaactgt atgatgggcg ataacagaca aatgcttctc 1574401 attacaggtc caaacatgtc agggaaaagc acgtatatga gacaaatcgc gctcatttcc 1574461 attatggcgc aaatcggctg ctttgtaccc gcgaaaaaag cggtgctccc gattttcgat 1574521 caaattttta cgcgaatcgg cgctgcagat gatttgattt ccggacaaag tacatttatg 1574581 gtagaaatgc ttgaagcgaa aaatgcgatt gtcaatgcga cgaaaaacag cctcattctg 1574641 tttgatgaaa tcgggcgggg aacgtccact tatgacggca tggcgctggc acaggcgatt 1574701 attgaatatg ttcacgatca tatcggcgcc aagacgctgt tcagcacaca ctatcacgag 1574761 ctgaccgttc ttgaggacaa gctgccccag ctgaaaaacg ttcatgttcg cgctgaagaa 1574821 tataacggaa cggttgtctt tcttcatcaa attaaagaag gtgcggctga taaaagctat 1574881 ggtatccatg tagctcagct tgccgaactg ccgggagatc tgattgcgcg cgctcaagat 1574941 attttaaaag agcttgagca ttcaggaaac aaaccggaag tgccggtgca gaaacctcag 1575001 gtgaaagaag agccggcaca gctgtccttt tttgacgaag cggaaaagcc ggctgaaaca 1575061 ccaaagcttt caaaaaaaga aaagcaagtg atcgatgctt tcaaatcact taatatactg 1575121 gatatgacac cgcttgaagc gatgaatgaa atgtacaagc tgcaaaagaa attacattaa 1575181 aacggggtga tgaatgtggc aaaagtcatc caactgtcag atgagctttc aaataaaata 1575241 gcggcgggcg aggttgtgga acggcccgcc tcagtcgtca aagaattggt ggaaaatgcg 1575301 atcgacgctg acagcacagt cattgaaatc gatattgagg aagcaggcct tgcatccatt 1575361 cgggtcttgg ataacggcga aggaatggag aatgaagatt gcaagcgagc tttccggcgc 1575421 cacgcaacga gtaaaataaa agatgaaaat gatttattca gggtgagaac gctcggtttc 1575481 aggggagaag ccctgccgag tatcgcgtca gtctctcatc tggagattac aacaagcact 1575541 ggtgaaggag ctgggacgaa gctcgtcctc caaggaggaa acatcatttc cgaatcgcgt 1575601 tcctcaagca ggaagggaac tgaaattgtc gtttccaacc tgttttttaa cacaccggcc 1575661 cgtttgaaat atatgaaaac cgttcataca gagcttggaa acattacaga tgtggttaac 1575721 cgtattgctc tggcgcatcc agaggtatcg atccgcctgc gccatcatgg gaaaaacctg 1575781 cttcaaacga acggaaacgg agatgtgcgc catgtactgg cagcgattta cggcacggct 1575841 gtcgccaaaa aaatgcttcc gctgcatgtg agctccttgg attttgaagt aaagggatat 1575901 atcgccctcc cagagattac acgggcgtcg agaaactata tgtcgtctgt ggtcaatggc 1575961 cgttacatta aaaatttccc gctcgtcaaa gcggttcatg aaggctatca tacgcttctg 1576021 ccgatcggac gccatccgat tacttttata gaaattacga tggacccgat tttagtcgat 1576081 gtcaacgtgc atccatcgaa gcttgaggtc cggctcagca aggaaacaga gcttcatgac 1576141 ttaatacgtg acggaattaa agatgtgttt aaacagcagc agctgattcc tagtgcccag 1576201 gtcccgaaaa aatcagcacc tgccatcaaa aatgagcagc agtttataac ctttgatgaa 1576261 aagcctccgg aaaaaaaagt tccggaaaaa tcgactgcgc catcttattc accgatgaag 1576321 ctcagctcag tcgtaaaaga gccggttgat gcggaggaaa aattgccccc tctccaattt 1576381 gatgctcctc ctatcgttga tcaggaacaa acccttgagg tgtccgatgt ttcagcagaa 1576441 cagcctgaaa catttgagca ggaatgccat gaggaacagc cgcagccagc gtctgatcgg 1576501 gttccaatta tgtacccgat tggccagatg cacgggactt atatattggc acaaaacgaa 1576561 aacggcctat atattatcga ccagcacgcc gcccaagaac gtattaaata tgagtacttc 1576621 cgtgaaaagg tgggggaggt tgagcctgag gtgcaggaga tgattgtacc gctgacgttc 1576681 cactactcca caaatgaggc tttgattatt gaacagcaca aacaagagct cgaaagcgtc 1576741 ggtgtctttt tagagtcatt cggctctaac agttacatcg tccgctgcca cccagcctgg 1576801 tttccaaagg gagaagaagc agagcttata gaagaaatca ttcagcaggt gctcgactcc 1576861 aaaaatatag atattaaaaa acttcgcgag gaagcggcga ttatgatgag ctgcaaaggc 1576921 tccatcaaag caaatcgcca cctcagaaac gacgaaatca aagcgcttct ggacgacctc 1576981 cgaagcacat cagacccatt tacatgcccg cacggccgcc cgatcatcat tcaccactcg 1577041 acatatgaga tggaaaagat gttcaaacgc gtgatgtagc gggggtggta ggcattgatc 1577101 cattctctga atgggaattc acggggcata cggataatag gggtatccgc catacaaata 1577161 aggattaaat aaagcgcttc ctataagccc gcctgcaagg ccgccgataa acggtcctcc 1577221 aaaaaatccg aatggccggc caaacccata accaaatccg ggtcttccaa acccgtaacc 1577281 gaacccgaac ggtcttccaa acccaaatgg tctcccgaat ccgaacggcc ttccaaatat 1577341 tcttgtatct tcagggctga aatgctctaa ctcgttcatg ttttctttcc tcctgtaata 1577401 aagtgtagat gatgcagtgt attcaccctg cccggatttg attgggcgaa tcgaggaaaa 1577461 ggaggatgtg aacacattgg gcctgtatca gtctgactgg tcaaaagcac cgccccacgc 1577521 acatgcttat catgtcaaaa caacgagaga acagggccat tatcatctca tcgaagggtt 1577581 tactcagccg gcaaacggat caaataccga tcagcataca cattactata cagggatcac 1577641 ttcatttgaa aacggccatt ttcatcggta ttacggaatc tcaggaccgg cgattccctt 1577701 agcagatggc acacattatc atgaaatcga agaaacgacg tatctggcct ataacgagcc 1577761 gattgagatc cagtacggag gggttgtgta cgatcccgga gatgacagaa gaaaaacgca 1577821 tcgtcatacc ctgaaaggaa agacaaggga aattgtcggc aatgagccgc tcggctggta 1577881 gaaggatgtt taccgatgca aaaaaagggc aaaatggata ggtggttgtc catgttgaat 1577941 gctataatgg ggggagattt ataaaagaga gtgatacata ttgaataata cgaagcagcc 1578001 cgttgtcatt ttagtcggac cgacggcagt ggggaaaacc aatttaagta ttcagctagc 1578061 caaatcctta aacgcggaaa ttatcagcgg agattcgatg cagatttata aagggatgga 1578121 tattggaaca gctaaaatta ccgaacagga gatggaggga gtgccccatc atctgattga 1578181 cattttagat ccccaagact ctttctctac tgccgattat caaagcttag taagaaataa 1578241 aatcagcgag attgcaaata gaggaaagct tccgatgatt gtcggcggta cagggcttta 1578301 tatacaatct gtgctttacg attatacatt tacggaagag gcaaatgatc ccgtgtttcg 1578361 agagagcatg caaatggctg ctgagcggga aggcgctgac tttcttcatg ccaaacttgc 1578421 tgcagcagat cccgaggcag cagctgcgat tcatccgaat aatacaagaa gagtcattcg 1578481 cgcactggaa attttacata cgtccggaaa aacgatgtcc cagcatttga aggaacaaaa 1578541 acgagaactt ctgtacaatg cagtgttaat tggcctgaca atggatagag acacgcttta 1578601 cgaaagaatt aatcagcggg tcgatttgat gatgcagtca ggccttcttc cggaagtgaa 1578661 acgcttatac gacaagaacg tgagagactg tcaatcaata caggcgatag gctataaaga 1578721 gctgtatgca tattttgacg gttttgtgac actttccgat gctgtcgaac agctaaagca 1578781 gaactcgagg cggtatgcga aacgccagct gacgtggttt cgcaacaaaa tgcaggtcac 1578841 atggttcgat atgacaccgc ctgttgatat ggagctgaaa aaaaaggaaa ttttcacaca 1578901 tatagcagga aaactcgaac tttaatcgaa actgtatgat atagagaatc aaggaggacg 1578961 aaacatgaaa ccgattaata ttcaggatca gtttttgaat caaatccgga aagaaaatac 1579021 gtatgtcact gtttttttgc tgaacggctt tcagttgcgg ggccaggtga aaggctttga 1579081 taactttacc gtattgttgg aatcggaagg taagcagcag cttatatata aacatgcgat 1579141 ctcaacgttt gcgccgcaaa aaaacgtcca gcttgaactc gaatagatca aaaaatgcca 1579201 tgtcaagaca tgaggaaagg ctgtcggggg ttcccggcgg ccatttttaa catgaatcca 1579261 cttttgctcc aagctttttg tgtaagctga ccatgccaag gcacggtctt tttttatgag 1579321 aacaacatac ggaagtaaaa atggtatatt atgtataaaa tgaatttggg agtgatcgat 1579381 cttgtttgaa agtgaagcag aactgagacg aatcaggatt gcacttgtat ggatagctgt 1579441 ctttttactg ttcggggcgt gcgggaatca agataccatt attgaaacag acaacggcaa 1579501 ttcagactat gaaacgcctc agcccacctc gtttccactt gaacataacc attttggcgt 1579561 tatggaggac ggctatatca aaatttatga gtataatgag tcccgcaatg aggtaaagct 1579621 gaagaaagaa tacgcggatg atgagcttga ataaaattca caagcattcg aatttacaaa 1579681 gcggatgcca gccgctaaac taaatacaga cacagatcaa acagagggtg aaaacatgaa 1579741 gcataaagtg atcgtgaatc attgggaaga aatttgcgaa gatgattctt gctatgaata 1579801 cggaacaagt atcattgtga acggaaaaga attaatcaga gaagcgtcaa ttatcactgc 1579861 tttgaaggcg gttttagaag agatcggcgc ggatgttgaa atagaagaaa cagtagagag 1579921 cgaaaaatgc tgtgatagct taagaaaaaa aaatctagac tactaagcag ttttttttca 1579981 tgttatgata tacatcggct aaaaacgaca ccccgagtag gacgagagat gattctcgtt 1580041 ctgctctctt ttttgggccc taatgagtct gcccgtttgc ctgatttgat caaaatatga 1580101 atttttcata aaaacgaatc tatatattgt gtttttgcta gagggtagta tactatatat 1580161 agtgttagtg atgagagatt catatttttt gataggtcgt gataaaacgt ggtacaaatc 1580221 atatttgatt cgaaaacagg gaatgttcag cggtttgtga ataaaacagg ctttcagcag 1580281 atacgcaagg tggacgaaat ggaccacgtg gacactccgt ttgttttggt cacctacacg 1580341 acaaacttcg gccaggtacc ggcatcaaca caatcatttc tcgaaaaata cgcccatctc 1580401 ttattgggag tcgctgcgag cggcaacaaa gtatggggcg ataactttgc aaaaagcgcc 1580461 gataccattt caagacaata tcaggtgccg atcttgcaca aatttgaact cagcggcaca 1580521 tctaaagacg ttgaattgtt tactcaggag gtagaaagag ttgtcacaaa atcaagtgcc 1580581 aaaatggatc cagttaaata acgaaatcat gatccaaaaa gatgggaaat tccagtttga 1580641 taaggataaa gaagctgtac atagctattt tgtagattat atcaatcaaa acacagtctt 1580701 ctttcacaat ttaaaagaga agctggatta tttggttgaa aaccaatact acgaagagga 1580761 attcttaagc ctttattctt ttgaagacat taaagaagtg tttaagacag cttacgctaa 1580821 gaagtttcgt tttccttcct tcatgagtgc gtttaaattc tataatgact atgctttgaa 1580881 aacgaatgac aagaaaaaaa tcctcgagcg ttatgaggac cggatctcaa ttgttgcgct 1580941 gttcttcgct aacggcgaca ctgagaaagc aaaagaatat gtaaacctga tgatcaatca 1581001 agaatatcag ccgagcacac cgacattttt gaatgccggc agaaaacgcc gcggtgaact 1581061 tgtgagctgc ttcttgctcg aagttaatga ttctttaaat gacatttcaa gagcaatcga 1581121 tatctccatg cagctttcta agcttggtgg cggggtttct cttaacctgt ccaagcttcg 1581181 cgcgaaaggt gaagccatta aagatgttga gaatgcgaca aaaggcgttg taggcgtcat 1581241 gaagcttctt gataacgcgt tccgttacgc tgaccaaatg ggacaaagac aaggctccgg 1581301 cgcggcgtat ttaaacattt tccaccgcga tatcaatgat tttcttgata cgaaaaagat 1581361 ttctgcggat gaagatgtgc gtgtcaaaac gctttcgatc ggtgttgtca ttccggataa 1581421 gttcgttgag cttgcacgcg aggacaaagc ggcttatgta ttctacccgc acacgattta 1581481 taaagagtac ggccagcaca tggatgagat ggacatgaac gaaatgtacg acaagtttgt 1581541 cgacaaccct cgggtgaaaa aggaaaaaat caacccgcgg aaactgcttg aaaaattggc 1581601 gatgcttcgt tctgaatcag gctatccata catcatgttc caagataacg tcaataaagt 1581661 gcatgcgaat aaccatattt ccaaggtcaa attttctaac ctttgctctg aagtgctgca 1581721 ggcatctcaa gtttcttcat acacagacta tgatgaagaa gatgaaatcg gtctggatat 1581781 ttcctgcaac ctgggttcgc ttaacattct caatgtcatg gagcataaat caatcgaaaa 1581841 gacagtcaag cttgcgacag actctttaac acacgtgtct gaaacaacag acatccgtaa 1581901 tgcgcctgct gtaagacggg caaacaaagc gatgaaatca atcggcctcg gtgctatgaa 1581961 ccttcacggc taccttgcgc aaaacggcat tgcgtatgaa agtccggaag cgcgtgactt 1582021 tgcaaacacg ttctttatga tggtgaattt ctactccatc cagcgttctg cggaaatcgc 1582081 aaaagagaag ggcgaaacgt ttgatcaata tgaaggatca acctatgcga caggtgaata 1582141 cttcgacaaa tacgtttcaa ctgatttctc accgaaatac gaaaaaatcg ctaatctgtt 1582201 tgaaggtatg catatcccga cgacagagga ctggaaaaag ctaaaagcat ttgtcgctga 1582261 acacggtatg tatcacagct acagattatg cattgcgccg acaggctcta tctcatacgt 1582321 tcaatcaagc acggcgtctg ttatgccgat tatggaacgg attgaagaac gaacatacgg 1582381 caactcaaaa acgtactacc caatgcctgg gcttgcatct aataactggt tcttctataa 1582441 agaagcctac gatatggaca tgttcaaggt tgtggatatg atcgccacta tccagcagca 1582501 cattgatcag ggaatcagct ttacattgtt cttaaaagac acaatgacga cccgagattt 1582561 aaaccgaatc gatctgtatg cacatcatag aggaattaaa accatttact atgcaagaac 1582621 gaaagatact gggcaagaca gctgcctttc ttgtgttgtt tgattaaagg agagtttata 1582681 gtgacaaaaa tttatgacgc agcaaactgg tcaaagcatg aagacgattt tacccaaatg 1582741 ttctataacc aaaacgtgaa acagttctgg cttccggaag agattgcttt aaacggcgat 1582801 ctcctcacat ggaagtacct cggaaaaaat gagcaggaca cttatatgaa ggtactggcc 1582861 ggacttacgc ttcttgacac agagcagggg aatacgggga tgccgatcgt ggctgaacac 1582921 gtagatggcc accagcggaa agcggtgctg aactttatgg cgatgatgga gaacgctgtc 1582981 catgcgaagt cgtactctaa tattttcatg acccttgcac cgactgaaac gatcaatgaa 1583041 gtatttgaat gggttaaaca aaataaatat ttgcagaaaa aagcgcaaat gattgtcggg 1583101 ctttacaaag ccattcaaaa agatgatgaa atttcactgt tcaaagccat ggttgcttcc 1583161 gtctatctgg aaagcttcct tttctacagc ggtttctatt atccgttata tttctacgga 1583221 caaggaaaac tgatgcaaag cggtgagatc attaacctga tccttcgtga cgaagcgatt 1583281 cacggcgtgt atgtcggtct ccttgctcag gaaatttata ataaacagac agaagagaaa 1583341 aaagcagagc ttcgtgaatt tgcgatcgac ctcctgaatc agttatatga aaatgagctt 1583401 gagtatacag aggacttgta cgatcaagtc gggctctcac atgatgtaaa gaaattcatc 1583461 cgctataatg cgaataaagc gctgatgaac cttggatttg atccatactt cgaagaggaa 1583521 gacattaatc cgatcgtttt aaacggatta aacacaaaaa caaaatcgca tgacttcttc 1583581 tctatgaagg ggaatggcta taaaaaagcg acagttgagc cgctcaaaga tgatgacttt 1583641 tattttgaag atgaaaaaga gcagatataa tatctgctct tttcggcttg aaggttcaaa 1583701 tgaggaggac gcagtaccca tgggaaaaat ggacgaaatg attttagttg ccccgcgcga 1583761 tgatgtgttt aaaaaagaaa gcttaacctt ccagggcgtg tacagtgaag atagcagagt 1583821 agcagaaatc atggctcaga ttgaagcggc ctatcgtgaa atgagaagag gggacgcaga 1583881 agaagatccg cgtttcaagc agccgatacc ttatgtcgtc attaagcgtg aagatgaagt 1583941 ttttctttac gagcggctgg ctggcggcgg tgaatcacgt ctgcacaaca agctttctct 1584001 cggttttggc ggccatatga acgccatcga aggggcagct tcatttgctg aagtcttaaa 1584061 gctgaacaca gaccgtgagc ttgaggaaga actgcaaata aatgaagaag ataaacaggc 1584121 gattgtcaca ctgggattga tcaatgatga tgaaaacagt gttggcaaag tgcatatcgg 1584181 tattctttct gcgcttcaat taaagcctgg cgcacaagtg gaagtgaagg agaaagaaca 1584241 aattgcgggt aaatggatga aagtttctga attaaaacag gatgatatct acaaccgtct 1584301 ggaaacatgg tcacagtttg ttgttgatat tcttgaataa aaaaacccgg tttctcgcga 1584361 tgaggagccg ggttttttta tgagacgctc gtccccgtct cggctatgat tctaggatca 1584421 caatagcgtc aaagccggca tttttcgctc tggcagcgag ggtgtctgca ttgtctttgg 1584481 atgaaaatgc gccaatctgc actttgtata atccgtcctt taaaaggaca atcgagtcaa 1584541 aacctttggc ttcggcatta cttgcgagcg agtcggcatt cgctttgact ttaaatgcgc 1584601 cgatttgaac cttatataac cctgagctgg aagtcttttt aaggttaaag gcttgctcca 1584661 gcccgtttgc atgtcctctc gctaagcttt gaataaaact gctcgttttc agcttatttg 1584721 catcggaaac ggtatcaatg aagccgttct cggtcaagag ggcaggcatt gccgactccc 1584781 ttaggacgtg gaagttcgct gtttttttgc cgcgatcggc aaagtcgaca gcttgtatca 1584841 cttcagagtg aattgtcgat tgataagtcg tcgtcggggc tcctacatct ggataaatat 1584901 agctttcaaa acctgtgcct cccccggaat taacgtgaat ggacaaaaag aaatctgctc 1584961 cccagttatt tgcggcattt gtccggtcgt ttaagctgac atattggtcg cttgtccggc 1585021 tcagcagcag agaaacgcct tcatattcat tagttaatat cgtacgtaag gctaaagcga 1585081 tttgcagggt taacgttttc tcctgaaggc cattacctgt tgcgcctgga tcagacccgc 1585141 catggccagg atcaataaaa attttaacca tttttcatca cctcattaca ggatatgaaa 1585201 aaacacggct tctgcttgta cgattatcat tcaactgaaa aatgaggaaa taaccctttc 1585261 acatccagaa attatttctc gggaaagcgc acaattcaac atgaagcgac aacagatacg 1585321 gtccgacatg aaatctgtgc atacgccata tgtttgtatg tactatgggt tcggttaacc 1585381 tgcactgatt cctgctggtt ttaagctttg cgttcatatt aaatcaagca tttaaaacgt 1585441 aaattgatga ggaaagctcc tttcattaaa gacaccgctt tataaatcga aaaaaagaaa 1585501 aacacttcag gtatcttagg gcgggtaata cgtttcgtac aaaaatcagc ccgttgtatg 1585561 aaaaagaaat aatgagaaag aagctcacta taatactctg acaaaatgat taaaaacaaa 1585621 atctcatggt ttgtccaccc catgtccgtg aatacaataa gaaataaagt atttctcggg 1585681 aaagcgcagg attccttatt gttcccgaaa aaagcaattg tttcgacaca tgataggcgt 1585741 ttgtcacaat cggcatccgc ttgaatatca tatagagaga acagagaggt gaagatgttg 1585801 gagcgcgctg tgacttataa aaacaacgga cagatcaaca ttattctgaa cgggcaaaag 1585861 caggtgctga cgaatgctga ggcagaggcg gaatatcagg ctgcattgca aaaaaacgaa 1585921 gcaaagcacg gcattttgaa ggaaatcgaa aaagagatga gcgcattagt tgggatggag 1585981 gaaatgaaac gcaacatcaa ggaaatatac gcctggattt ttgtgaacca aaaacgcgcg 1586041 gagcaaggct tgaaggttgg aaagcaagcg ctgcacatga tgtttaaagg aaatccggga 1586101 acgggaaaaa cgacggttgc acggctcatc ggcaagctgt tctttgaaat gaatgtcctg 1586161 tcaaaaggcc acttaataga agcggagcgg gctgacctgg tcggggagta tatcggacac 1586221 accgcccaaa agacgagaga tttaatcaaa aagtcattag gtggcatttt gtttatagac 1586281 gaagcctact cgctggcaag aggcggcgaa aaggactttg ggaaagaagc gatcgacaca 1586341 cttgtaaagc atatggaaga caaacagcat gagtttattt tgatactcgc cggatattca 1586401 cgggaaatgg atcattttct ctcgttaaat cccggactcc aatcaagatt tcccatctcc 1586461 attgattttc cggattactc tgtgacccag ctcatggaga ttgcgaaacg aatgatcgat 1586521 gaaagggaat accagctcag tcaagaagcg gaatggaaat tgaaagatta cttaatgaca 1586581 gtgaaaagca cgacaagtcc cattaaattc agcaatggac gttttgtcag aaatgtgatc 1586641 gaaaaatcga tcagagcaca agccatgagg cttttaatgg gagaccaata cttaaaaagc 1586701 gacttgatga ccatcaaaag ccaagatctt tccattaaag aagaagcatc tggatctgca 1586761 tagacctctc agtttttgag aggtctgttt tttgctcgta tttccgcttt tcaaagcaat 1586821 cgatttgtgg tatacacatg cagggtttgg tatgataata ctactgccca atatgcaaaa 1586881 gaaaggaaca tccatttgaa cgaacaagaa acgattcagg agaaagccat tttagtcgga 1586941 tgtcagctgc cgcatatcac ggatgagcat tttgaaaatt ctatggaaga gctagcatct 1587001 ctgacgaaaa cagcagacgg aaaagtactg accagcgtca cacaaaaacg gaacagggct 1587061 gacgccgcta catatatagg aaaagggaag gtagaagagc tgaaggcact cgtggaagag 1587121 cttgaagctg atctcctcat ctttaatgat gaactgtcgc caagtcagct gaagtcattg 1587181 gcaacagcaa ttgaagtgaa gatgattgac cgcacgcaat tgatattaga tatttttgca 1587241 aagcgggcga gaacgagaga aggcaaactt caaattgagc tggctcagct gcaatatgca 1587301 ctgccgcgtc tgacgggaca agggatcaac ctttcccggc aaggcggagg aattggggca 1587361 agaggtcccg gggaaacgaa actggaaacc gaccgccgcc atatcagaaa tcgcattcat 1587421 gaaatcaaca cacagctttc cactgtcatt cgccatagaa gccgataccg tgaaagaaga 1587481 aagaaaaacg gtgtgcttca aattgcgctt gtcggctata caaacgcagg gaaatcaaca 1587541 tggttcaacc gcctgacgag tgctgacagc tatgaagaag acctcctgtt tgccacgctg 1587601 gacccgatga ccagaaaaat ggtcctgcca agcggctaca gtgttcttct ttcagataca 1587661 gtaggattta ttcaggatct tccgacgaca ttgattgctg cattccgctc aacgcttgag 1587721 gaagtaaaag aagcggattt aattctgcat ttaattgatt cttcaaatga ggattatgcg 1587781 ggacatgaaa aaacagtgct tcggctgctt gaggagcttg aagcagatga tatcccgatg 1587841 ctgacggctt acaataaacg tgatcaaaaa ctgcctgatt ttataccgac cgccggaagg 1587901 gatcacatta tggtcagtgc gaaatttgag gacgacgctg cagcctttaa agaagcgatt 1587961 cagcgctatt tgcgccaaga actgttaacg tcttttgaag cacatgtgcc ggcaagtgaa 1588021 gggaagctcc tttccagaat caaatcggaa acgatggtag accgcttcta ttttaatgaa 1588081 gaaaatgaac agtatgacat atccggctat gtccaagaag agcaaagtat catcggtgaa 1588141 ttaaagaagt atatgtagga aggaaatata aagacatgtt tgacacatta acacacggag 1588201 aattattgaa gaaaacggca atggaagtgg aagcggacat tgccggcatt cataaacaaa 1588261 tagaagaaat cagcgagcga aatgagtgga gagtgcttca aagctataga aaacacaaag 1588321 taagcgacac tcatttcacg ccgtctactg gatacggcta tgatgatatc ggaagagaca 1588381 cgcttgaaag catatatgcg gatgtgtttg gcggagaagc ggggcttgta aggccgcaaa 1588441 tcatttcagg cacacatgcc atctcaattg ctttgttcgg tgtcctcaga ccgggggacg 1588501 agctccttta tatcacgggc aagccgtatg atacgctaga ggaaattgtg ggcgtcaggg 1588561 gtggagaaaa cgctggttcg ttaaaggatt ttcaaatcgg ctataatgcg gttgatctga 1588621 cgaaagacgg aaagatagac tatgatgcag tcgccgctgc gatcaatccg aagacaaaag 1588681 taatcggcat tcagcgctca aaaggatatg cgaatcgccc ttctttctta attagtgaaa 1588741 taaaagaaat gatccgtttt gtaaaagaaa tcaatgaaaa tctgatcgtc tttgtggaca 1588801 actgttacgg agaatttgtg gaagagcttg agccttgcca tgtcggagcc gacctgatgg 1588861 cgggatctct cattaaaaat cccggcggcg gccttgcgaa aacaggcggc tacctcgtcg 1588921 gaaaagcgaa atggattgaa gcttgctcat accgtatgac gtcacccggc atcggcagag 1588981 aagcgggggc atctctttac tcgctccaag aaatgtacca aggcttcttt ttggcgcctc 1589041 acgttgtgtc tcaaagttta aagggagcgg tgtttacagc gagattcctt gaaaaactcg 1589101 gcttcacttc aaacccgaaa tgggatgcga aaagaacgga tttaatacaa tccgttgagt 1589161 tttctgacag agaaaagatg attgcttttt gccaggctat tcaatttgca tcgccaatca 1589221 atgctcatgt gacgccttat ccagcctaca tgcctggata cgaggatgat gtcattatgg 1589281 cagcagggac gtttattcaa ggagcaagca tcgaattatc agctgatggc cctatccgcc 1589341 cgccgtatgt agcgtatgtt cagggaggat taacctattc gcatgtgaag aatgccatat 1589401 gcagtgcagt ggattcattg atgcaaaagc aattaattta aattttttaa aaatttctct 1589461 ggatttgatg ttaagaatcc ttacatcgta ttgacacata atataacatc acctataatg 1589521 aaactaagtt aagaaaagga ggaaattgag atgagtgata atattcgccg ctcaatgcct 1589581 ttatttccaa taggaattgt catgcagtta actgagttat cagcaagaca aattcgatat 1589641 tatgaggaaa atggactgat atttccagcc agaagtgaag gaaatagacg attattttca 1589701 tttcatgatg tagataaact gttagaaatc aagcacctga tagaacaagg tgtaaacatg 1589761 gcaggaatta aacagattct ggcgaaagcc gaagccgagc cagaacaaaa acaaaacgag 1589821 aagacgaaaa aaccaatgaa acatgatctg tccgatgacg aactgagaca gctcctgaaa 1589881 aacgagctca tgcaagccgg ccgttttcaa agagggaata cattccgtca aggcgacatg 1589941 tcccgcttct ttcattaatc cgttagcaac tgttttgcta tatacattta ccttttaaga 1590001 ggaggaattt taccaaatgg caaagtacac tagagaagat atcgaaaaat tagtaaaaga 1590061 agaaaacgtg aagtatatcc gccttcaatt tactgacatt cttggaacaa tcaagaatgt 1590121 tgagattcct gtaagccagc ttggaaaagc gcttgataat aaagtcatgt ttgacggttc 1590181 ttctattgag ggattcgttc gtatcgaaga gtcagacatg tacctgtatc cagatctaaa 1590241 tacatttgtt atcttcccat ggacagctga aaaaggtaaa gtagcacgtt tcatctgtga 1590301 tatttacaat ccggatggca caccttttga aggtgacccg cgaaacaact taaaacggat 1590361 tctgaaagaa atggaagacc tcggcttcag tgattttaac cttgggcctg agcctgaatt 1590421 cttcttattc aaattggacg aaaaaggcga gccgacgctt gaactaaacg acaaaggcgg 1590481 atatttcgac ttagctccaa ctgatttagg agaaaactgc cgccgcgata tcgtacttga 1590541 gcttgaagag atgggctttg aaatcgaagc gtctcaccac gaagtagcac ctggtcagca 1590601 cgaaatcgac tttaaatatg ctggagcagt ccgctcttgt gatgacatcc aaacatttaa 1590661 actagttgtc aaaacaattg cccgtaaaca cggcctgcat gcgacattta tgccaaaacc 1590721 attgttcggt gtaaacggtt caggtatgca ctgcaatcta tcactcttca aaaatggtgt 1590781 taacgcattc tttgacgaaa acgcagatct tcagttaagt gaaacagcga agcacttcat 1590841 tgcaggtatc gtgaagcacg caacaagctt tacagcagta acaaacccga cagtaaactc 1590901 ttacaaacgt cttgttcctg gctatgaagc accttgttat gtagcatgga gcgcgcaaaa 1590961 cagaagcccg cttatccgta tcccggcttc tcgcggcatc agcacacgtg ttgaagtacg 1591021 cagtgtagac ccagctgcaa acccatacct tgcacttagc gtattgcttg ctgcaggatt 1591081 agacggaatc aaaaacaaac tggaagcgcc ggctccaatc gaccgcaaca tctatgtgat 1591141 gagcaaagaa gagcgcatgg aaaacggaat cgttgacctt ccagcaacac ttgcggaagc 1591201 actagaagaa ttcaaatcaa acgaagtcat ggtcaaagcg ctgggcgagc acctattcga 1591261 acacttcatc gaagcaaaag aaatcgaatg ggatatgttc cgcacgcaag tacatccttg 1591321 ggaacgcgaa cagtatatgt ctcagtatta atatctcaat cccttggcac taaaagtgtc 1591381 aggggatttt ttatgttaat aggtaataaa ttatggagcg gcatagtgtt taacacagcc 1591441 attaatcctc agacagtcaa atagccattt ctactccggt tgaaagcttc tctatttttg 1591501 cttcttattt atctttcctg tattgatata tgtatgtagg gttggactta taacataaac 1591561 tattctggcc attccgttct ttcaattcat gaccgggctt gccatcagca taaatctagg 1591621 ctaacagtct ccatacatcc tgtgatcacc tttatcaaac tcttaaatgc aacttaccac 1591681 taaccaattc tttatttcgc atagatcatc tttgtcatgt gtttacacaa gaatctgttt 1591741 tggactgaga cactgaatat aacaaaacag tcaaaaatca atatttaatt cattctgttt 1591801 aaactttctg aaaaagatgt tgaaaaagtc gaaaggattt tataatatta agtcaagtta 1591861 gtttgtttga tcaacaaact aatgaaatga actttcatta tccacaagat aagatcttac 1591921 taatatggat ggaaggggga taagagggtc gatttaatgg agctaaacaa tataagaaac 1591981 gaaagaatga ggcttttatc cttttccagg tatataaggt atgacgaaaa aagatgaatt 1592041 ttttgcttgc tgatcaccat atttttttgc actgttttga aagcgctttt ataaaagttt 1592101 actgaccgta aattcgagaa attgttatac cgtttcacac tgttccatat taaaggatcg 1592161 aaaaggggag aaatcatgct cagtgaaaat gtaaagaaga ttagcatggt tgaaaaagtt 1592221 ggatatgcgt ctggagattt tgcttgtaat ttaatttatg caacagtgtc tacgtatctt 1592281 ttgttcttct atacagatgt ttttggttta tcggcagcag cagccggtac tatgttttta 1592341 gtggttagaa taatcgacgc tctcgctgat ccttttatcg gaacaatagt tgacagaacg 1592401 aacagcagat ttggacgctt tagaccgtat cttttattcg gagcttttcc atttgtcata 1592461 ctggcaatac tctgttttac aacaccagac ttttcggata tggggaaatt aatatatgcc 1592521 tatataacct atgttggctt gtcgcttaca tacacaacga taaacgttcc atatggcgcg 1592581 ttaacttctg caatgactag aaataatcaa gaagttgtta gtataacttc tgttcgcatg 1592641 ttatttgcga atcttggggg acttgtcgtt gcattttttg ttcccttact ggctgcttat 1592701 ttaagcgata cttccggcaa cgagtctctt ggctggcaac taaccatggg tattttggga 1592761 atgataggcg ggtgcctttt aatcttttgt tttaaaagca caaaagagcg ggtcactctt 1592821 caaaaatccg aagagaaaat taaatttacg gatatatttg agcagtttcg tgttaatcgt 1592881 ccacttgttg tattaagtat tttctttatt attatttttg gagtgaattc catcagtaat 1592941 tcggttggca tttactacgt aacgtataac ttagaaagag aggatttggt gaagtggtac 1593001 ggtttgatag gaagtttacc cgctttggtc attttaccgt ttattccaag gcttcatcaa 1593061 tttttgggga aaaagaaatt actaaactat gcattattac tgaatattat aggcctctta 1593121 gctttactgt ttgttccgcc aagtaatgtt tacctcatac ttgtctgtcg attaatcgct 1593181 gctgctggaa gtctcactgc cgggggatat atgtgggcgc ttattcctga aacaattgaa 1593241 tatggagagt acaggactgg gaaaagaatg ggtgggctca tttacgctat aatcggattt 1593301 ttctttaagt ttggtatggc cttaggagga gttgttccgg gtctggttct tgataagttt 1593361 ggatatgtag caaatcaggc acaaaccccg gcggccttaa tggggatttt aattacaaca 1593421 accattattc ccgtgttctt gcttgttcta gctttaattg atattaattt ctataactta 1593481 gatgagaaaa aatataaaaa catggttcga gaattagaga atagagacaa agtttatttg 1593541 gatcatattg atgatttcaa ggcttaaaaa agaaaataaa ctgaggagga gtcccaaatg 1593601 aagattacca atcccgtact taaaggattc aatcccgatc caagtatttg tagagcagga 1593661 gaggattatt atatcgctgt atctacattt gagtggtttc cgggagtcca gatacaccac 1593721 tcaaaagatt tagtaaattg gcacttagtt gcacatccat tacagagagt ttcacaatta 1593781 gacatgaaag gaaacccaaa ttcaggtgga gtttgggcac catgtttaag ctatagtgat 1593841 gggaagtttt ggctgatcta tacggatgtt aaggtagtag atggcgcatg gaaagattgt 1593901 cacaattatt tagttacttg tgaaacgatt aatggtgatt ggagtgagcc gattaaatta 1593961 aatagctcgg ggtttgatgc ttctttgttc catgatacgg atggaaaaaa gtatttatta 1594021 aatatgttat gggatcaccg tattgatcgg cactcatttg gaggaattgt tatacaggaa 1594081 tattctgata aagagcaaaa attaatcggt aaaccaaaag ttatatttga aggaactgat 1594141 agaaaactga cagaagctcc gcatctttat catatcggga actattatta tttattaact 1594201 gcagaaggag gaacacggta cgaacatgct gctacaattg ctcgttctgc aaatattgag 1594261 gggccatatg aagttcatcc cgataatcca attttaacgt catggcatga cccaggaaat 1594321 ccattgcaaa aatgtggtca tgcatccatt gttcaaacac atacagatga gtggtattta 1594381 gctcatttaa cgggacgtcc tattcatcct gacgatgatt caatttttca gcagagagga 1594441 tactgtcctt tgggcagaga aacagctatt caaaaacttt actggaaaga tgaatggccc 1594501 tatgtagtag gtggaaaaga aggaagcttg gaggtagatg caccttctat acccgaaaca 1594561 atatttgaag caacgtaccc ggaagttgat gaatttgagg attcaacatt aaatataaat 1594621 tttcaaactt taaggattcc attcacgaat gaattaggtt cattgactca agcgccaaat 1594681 catttacgat tattcggtca tgaatcattg acctcgacat ttactcaggc atttgtagcc 1594741 agacgctggc aaagtctcca ttttgaagcc gaaactgctg ttgagtttta tccggaaaat 1594801 tttcaacaag ccgctgggtt ggtgaattac tacaatacag agaactggac ggctcttcaa 1594861 gtcacgcatg atgaagaact tgggcgcatt cttgaattaa caatatgtga caacttttct 1594921 ttttcacagc cattaaataa taaaattgtt attcctcgtg aagtaaagta tgtatattta 1594981 agagtaaata ttgaaaagga caaatattat tatttctatt cttttaacaa agaagattgg 1595041 cacaaaattg acattgcact ggaatcgaaa aaattatcag atgattatat ccgtggggga 1595101 ggattcttca caggggcctt tgtagggatg caatgccaag ataccagtgg taatcatatt 1595161 ccggccgact ttagatattt tcgttataaa gaaaaataat ttgcacatga aaaaggagat 1595221 ttctatttta gaactccttt ttcatatgag aaggtgccat gtcactattg cttcagaaat 1595281 actcctagaa taaaaaaact catctttaaa gatgagctgt ccattccata aaaaattaca 1595341 ttgtaatcat gtccagaaaa tgatcaatca caatggagga cattcctaat gccggtgcat 1595401 tctgtcctaa ggaagatggc aataattcat agctattgcc taattgggaa taaacccttg 1595461 atgatacttc acttctcatt gaatttaaaa ccataggatg cgattcaatt atgctatttc 1595521 ttaaaattac ggcttgtggg ttgaaagtat ttagaatatt ggtaaggcct attcctaaat 1595581 agaatccaaa attttgtaat gcatttaagg ttccgatatc attcagatgg gcgaggttta 1595641 tgatatcttg ataggacagt tttttctctt tggtctgaag agattttaat aaagccttct 1595701 ctgaagcata caattcccag catcctcggt ttccgcaact gcatttagga ccattaaagt 1595761 ctattgtcat atgtcccatt tctccagaga agccgcttac tcctctatat aaatgattgt 1595821 tgataataac accgatccct attcctgtgc tgatacttac gtaaataatg ttatcgtgat 1595881 tttttgcagc tccaaatact ttttctccat atgcgccagc atttgcctca ttttcaataa 1595941 aaacaggcac attgtacttc tcttgtatcg aagattttaa gtcaatatct ctccagttgg 1596001 agttcggagt gaaaacaatt ttttgatctt tatcaatgag tccaggcacg caaataccta 1596061 taccaataag cccgtacgga gattggggca tttgcgtaat aaagtgatga atcatatcaa 1596121 tcaaaatgtc tttcgttatt tctggagaat tggattccaa atggcggtat tgatcaagaa 1596181 cgattgttcc ttcaaggtct gttaaaatgc cattaatata atccacacca acatctattc 1596241 caacggagta tcctgccttt ttattaaaaa caagcatgac aggtcttctt ccgccacttg 1596301 attgtccttg acctatttca aataccatac tttctttcat taacgtgttt acctgtgatg 1596361 agacagttga tttatttaat ccagtcattt cagataattt tgctcttgaa ataggtgaat 1596421 ttttaaggat ttcttttaat aataactttt gatttacttt tttgacaaag gtttgatcag 1596481 cgatatccac ttcatccact ccatttgttt aatctttaaa ttaagtatca acatagtaca 1596541 tagcgaatct tccctttatt atatctaatg tgttcataaa aaactaaaaa aaatattgaa 1596601 aatactgacg aggttatata agatgaaaat aagttagttt gtttaaacaa caaactaata 1596661 ggtgatgtac ttactatatg aaataaaatg catctgtatt tgaatgaatt tatttttaag 1596721 ggggaaatca catggctcaa tctcattcca gttcaatcaa ctattttgga agcgcaaaca 1596781 aagtggttta cgaagggaaa gattcgacta atcctttagc atttaaatat tataatcctc 1596841 aagaagtaat cggcggaaaa acgctgaaag agcatttgcg attttctatt gcctattggc 1596901 atacatttac tgctgatggt acagacgttt ttggagcagc tacgatgcaa agaccatggg 1596961 atcactataa aggcatggat ctagcgaaga tgagagtaga agcagcattt gagatgtttg 1597021 aaaaactaga tgcaccattc tttgcttttc atgaccggga tattgcacca gaaggcagta 1597081 cgctaaaaga gacaaaccaa aatttagata tgatcatggg catgattaaa gattacatga 1597141 gaaatagcgg cgttaagcta ttatggaata cagcaaacat gtttacgaat ccccgtttcg 1597201 tccatggtgc cgcgacttct tgcaatgcag atgtgtttgc gtatgctgca gcacaagtga 1597261 aaaaagggtt agaaacagca aaagagcttg gcgctgagaa ctatgtattt tggggcggcc 1597321 gtgaaggata tgaaacattg ttaaataccg atttaaaatt tgagcttgat aatttggcta 1597381 gatttatgca tatggcagtg gattatgcga aggaaatcgg gtacacaggg cagtttttga 1597441 ttgagccaaa accaaaagag ccgaccaccc atcaatacga tacagatgca gcaacaacca 1597501 ttgccttttt gaagcaatat ggcttagaca atcattttaa attaaatctt gaagccaatc 1597561 atgccacatt agccgggcat acattcgaac atgaattacg catggcaaga gtacatggtc 1597621 tgcttggctc tgttgacgca aaccagggtc atcctctttt aggctgggac acggatgaat 1597681 ttccgacgga tttatattct acgacattag caatgtacga aatcctgcaa aatggcggcc 1597741 ttggaagcgg cggattaaac tttgacgcga aggtcagaag atcttctttc gagcctgatg 1597801 atctaatata tgcccatatt gcagggatgg atgcatttgc aagaggattg aaagttgccc 1597861 acaaattaat cgaagatcgt gtgtttgaag atgtgattca acatcgttac cgcagcttta 1597921 ctgaagggat tggtcttgaa attatagaag gaagagctaa tttccacaca cttgagcaat 1597981 atgcgctaaa tcataaatca attaaaaacg aatctggaag acaggagaaa ttaaaagcga 1598041 tattgaacca atacatttta gaagtataac aggataagct ccagatcctg ctatcaatac 1598101 caagtcactg aattacccgt catgattcct ttcctattgc ttgttgttat gacgggtaac 1598161 ttctataatt aggatttatt tagagtgaat ggttttttaa aagggcaagg agtgaaaaaa 1598221 tgaagtatgt cattggaata gatcttggaa cgagtgctgt taaaaccatt ttagttaacc 1598281 aaaacggcaa ggtttgtgca gaaacgtcca aaaggtatcc gctcatccaa gagaaggcgg 1598341 gatatagtga gcaaaatcct gaagactggg ttcagcaaac aattgaagca ttggctgaat 1598401 tggtttctat atccaatgtt caagccaagg atattgacgg gataagctat tcgggacaaa 1598461 tgcatggatt agtactgctt gaccaagatc gtcaggtgtt acgtaatgca attctttgga 1598521 atgataccag aacaacgcct caatgtataa ggatgaccga gaaatttggc gatcatcttc 1598581 ttgacatcac aaaaaaccgt gttttagaag ggtttacatt acctaaaatg ttatgggtaa 1598641 aggaacatga acctgaactt tttaaaaaaa ctgctgtgtt tttgcttccg aaagactacg 1598701 tgcgattccg tatgaccggt gtcattcaca ccgaatactc cgatgcagca ggaactttac 1598761 ttttacatat tactcgcaag gagtggagca atgatatttg caatcaaatt ggtatttctg 1598821 cagatatttg tcctccgctt gttgaatctc atgattgtgt aggatcgctg cttccgcacg 1598881 ttgccgcgaa gaccgggcta ttagaaaaaa caaaagtgta cgctggggga gcagataatg 1598941 cttgcggcgc tattggagca ggtatccttt cttccggaaa aacattatgc agtattggga 1599001 cgtcaggggt catactttcc tacgaagaag aaaaagaaag agactttaaa gggaaagtcc 1599061 acttttttaa tcatggaaaa aaggattctt tttatacgat gggcgtcacg ctcgctgcag 1599121 gatacagctt ggactggttt aaaagaacgt ttgcaccaaa cgaatcgttt gagcaattat 1599181 tgcagggggt ggaagctatt ccgataggag ccaatggact gctatacact ccttatttgg 1599241 ttggtgaaag aacgccgcat gctgattctt ctattcgggg aagcttgatc ggaatggatg 1599301 gagcccataa tagaaagcat tttttgaggg caataatgga aggtatcaca ttctctttac 1599361 atgaatcaat tgagctattc cgcgaagcgg gaaaatcagt tcatactgtt gtttctattg 1599421 gtgggggagc taaaaatgat acgtggctgc aaatgcaagc tgatattttc aatacgaggg 1599481 taattaagtt agaaaatgaa caagggccag ctatgggggc tgcaatgctg gctgcctttg 1599541 gaagcggttg gtttgaatca cttgaagaat gtgcagagca gttcattcgt gaggctgctg 1599601 cattttatcc aaaggcgcaa aatgttcaaa aatataaaac actatttgat ttgtataaga 1599661 acatttacac tcacacaaag gatctcaata cagctttgaa gagctttcga aaaaactaat 1599721 gatgttattg tctggagatc aaccgaagaa caattaatga tcaatcatca tcaaaggcct 1599781 ttgataacat ggctgccttc ttttgaaaag atggtgagaa taaggtatcg caacctttaa 1599841 acagtattgg agtatccagc agacaaaacg aacgagtgga accgtatttt gtcagcgaac 1599901 acttcaagaa gtggggaagc ttaggaatgc caatgggtaa gatgtatgaa accgcgctaa 1599961 cgacggtaga gggatctctt gatttatgaa gaaataggaa ggatgttaac acacaaataa 1600021 cccctcacat tgacgtgaag gggtgttttt tattgttact atacagcgga aattttacag 1600081 gctagttgca tgattttagc ttgttaagca gaatggaact agactctcca tcatctcttt 1600141 ctcattcttt ggaaactgca ttctgctagg tttgctgctt tttttaacaa acagtgtttt 1600201 tctatttcac acagccatta aatcctctgt tcgtcacata accgctctta ctccaaattg 1600261 acagtttatc tgattttgct tcttgctcat ctagtctgaa ttggtctatg tattttgtgt 1600321 taggctcata tacatatgct actctggcca atccctcttt caataatgtc tcttgaacag 1600381 atttgccgtc aacataaacg tatgctaaca gtcttccata cttatctctg cgatcgcctt 1600441 tatcaaattc cagctgtagc ttaccgctgt tgaccaattc tttatttcgt ttcgacgcat 1600501 cctcaccgta tggttgaaca caagaatttg gtttcttcgt ctcaggtgta tcaacgagca 1600561 agtagcgaac tgtgtctttc tttccgttgt aaataacctt aatcgtatct ccatctattg 1600621 ctctatctaa tgtaacattg accaatttct tctgattttt tgaatgaggc gtgccagcct 1600681 tttgttctgt ctgattatat tcattagagt gagtatcttg agagacttgc tccgtcccat 1600741 tagaatctga atggtttttg gctgcgtgat ttgatccgca agctgccaaa gtaatactta 1600801 aaacgattgc gatcatactg atcaaaatct tcttcatatt gattccctct ttatcatttt 1600861 ctcttttcgc gattaaacat catcattata acgatatgga cattttttgt gaatggaaaa 1600921 cttcaaggga acttataaca ctccaaattg ccaatagtta acttcacaac gagatgatca 1600981 aaacatcacc atcacatagc ggaaataaat aatcctgaaa ataatattga ctgaaaatgc 1601041 ttttagaatt atgataatat gagaaatgac aataatgtga caaagacatt actacaacat 1601101 aacaactaat agcttaggtt tattctattg gttaaaaatg taaacggtta caaatccaga 1601161 ggcgaaaatc taagatagag atgactttag ttttgactca atatccacac tgaaagagct 1601221 tattaagtat tcttaaaggc aggggaaatg gatatgaatg aacatcgaaa tcgaaggttg 1601281 aaattaataa tgatttcagc aacttttgga gggcttctct ttggatatga caccggagtt 1601341 ataaatggag ctttaccttt tatggcaagg ccagatcagc ttgatttaac acctgttaca 1601401 gaagggcttg ttacgagtat tcttttatta ggtgccgcgt ttggagcgtt gttatgcgga 1601461 agattggctg atcgatatgg ccgccgtaaa atgatcctta atctttcctt tttatttttc 1601521 ctggcatcac tgggaacagc gttagcacct aatgttttca tcatggcggt ctttcgtttt 1601581 ttactggggc tggctgttgg aggagcctcg gcgatggtgc cggccttttt agcagaaatg 1601641 gcaccgcatg aaaagagagg gcgtatggta acccaaaatg aactaatgat tgttggcggg 1601701 caatttttag catatgtttt taatgcgatc ctcggtgtaa caatggcaaa tacgggacat 1601761 gtttggagat acatgctagt catttgtgct gtaccggcta tcatgttatt tgccagtatg 1601821 cttaaggtac cagaaagccc ccgatggcta atctccaaag gcaaaaacag tgaggcgctg 1601881 cgagttctta aacaaattcg agaagataaa cgtgcagaag ctgaatgtag agaaattcaa 1601941 gaagcggtag aaaaagatac agcactagaa aaggcatcac tcaaggactt ttctacacca 1602001 tggctgcgcc gtcttttatg gattggaatc ggtgttgcca tcgtgaatca aattacaggt 1602061 gtgaactcga ttatgtatta tggcacacaa atccttaaag aatctggttt tggtacaaaa 1602121 gcggctttaa tcgctaatat tggaaatggg ctgatatcag ttattgcagt tatatttggg 1602181 atttggctgg tcggaaaagt gagacggcgt ccaatattat tgattggttt ggcagggacg 1602241 actacagcgc tcctattgat tgcgattttc tcaattgtgc ttgatggatc tatggcactt 1602301 ccttatgtag tgctttcttt gaccgtttta tttcttgcct ttatgcaagg gtgtgtagga 1602361 cctgtgactt ggcttgtcat agcggaaata ttccctcaaa ggttaagagg acttggttct 1602421 gggataagtg tttttttcct ttggatatta aactttgtga tcggttttgc tttcccgatc 1602481 ttgcttagct ctgtaggttt gtcttttaca ttctttatat ttgtggcttt aggtgtattg 1602541 gcaatcggtt ttgtgtacaa attcatgccg gaaacaaaag ggcgtacact tgaagaatta 1602601 gaagagcatt ttcgttctcg acacgatcat aatactcctg aacaatcagt tattgaggta 1602661 taaatatgtt gaaaatctct cttcttatag gagggatttt tttagtttca gaaaaaacaa 1602721 aatccctctg gtagagggat tttgattcag cattttaaga tgttctacac gtataatact 1602781 ggagttgata ctttaaaaat ctcgccatct cttatataaa aacgagggat gcggcggctt 1602841 aatgtagaca cgacttcata gttaatcgta ttgagcattt cagccacttc atcaacggaa 1602901 atctcggctc ctttttgctt accgtaaatc acgacttcat ctccttgttt accttcaccg 1602961 ttttctccta aactgaccat gatcatatcc attgttactc ttcccgccac tggcactcgt 1603021 tttccgcgat gaagaacaaa cccgcgattg gaaagggcac gagaatagcc gtcagcatag 1603081 ccaatcggga gtgtagcaat tacttcatta ggttctgcga tgtatgtagc accatagcta 1603141 acggttcggg gttctgtccg catggttttc acataagcga tgcgtgcctt taaacttaac 1603201 gcaggttcaa gcttaacgag atttagttgt ttaatatagg ctgaaggata taaaccatat 1603261 aagccgatac ctaaacggat catatcagcg ctaaattccg gaaatgcgat agctgcagcc 1603321 gtgttgcaca tatgcacggt gggcagctca atcccctgtt tttttaaaaa gctgagaaaa 1603381 ctgatgaatt tttcatgctg cagctttgtg agtgttgtgt ccggttcatc agctgtcgaa 1603441 aaatgtgtga aaatccctgt ccatctgagg aatttacttg cctttaaggc tttcactacc 1603501 tctaaaagtt cttcctttgt gcgtacacct aatcgtccca tgccggtatc cacgttaata 1603561 tgaatggcca gccggttagc actcgcttct ttttccaata tctcgtttgc ttctttcatc 1603621 caatcaacct gaaatgctga taatgttata ttccaagctg ctgacttctt tacacaacta 1603681 agggatgtaa aaccaagcac aaggataggt gctgtaatcc cagctttacg taaaacgatt 1603741 ccttcctcca cactggcaac agcgagctca ctcgccccgt gttccagtgc atggcgtgcc 1603801 acttctatag acccgtggcc ataaccgttc gcttttacaa cagccataat tttgctctta 1603861 tgtggaatat gacggcggat cgctcgcaaa ttctttttaa cggcatcaag attgacttcg 1603921 atccaaactt ctcggcaaag ctttatcatc aacgcttcct tccttcttat ggattataaa 1603981 taccacctat tgccgcaaga ataaatgtta attgttggat gattcgatct tattttattc 1604041 aactttattt gaaatcattc aacagcaaat ccatgtgata cgagaaggtg cctatcaatg 1604101 ttcgaataat agcaagtacg ggatacatga ggcttgtaag tggggtgtta atggatgcgg 1604161 cgaccgagga ttacaaaaat gattatttgt tttgggacat ttttttctaa gggtagatga 1604221 taacgagaaa tctaatcagg aaatacttac cgttgttatg aacattgaag aaccttttaa 1604281 atgagaaggg ctgaggaaat tctgtaaaag ataatcggtt gaaaaggcag tcgattcctt 1604341 gttccataaa cctaacatca gagtatataa ttatactcgt attcacaaaa atcgtttaag 1604401 taaggggtat acatgaatag gggagttagt tttcaaatac cgaatgaata tggaaatttt 1604461 ctatggagaa tactgcagcc ggtagaaata gctaattata ggtggcaaac gagtggggaa 1604521 tcttattttg ttgtagaagg agagctcgat gatgaggagc tttttcatga ctacgaaatt 1604581 gttgaggggg cagtttttga gcaacaatta aaaacgaatc agtactatac cattttcgtt 1604641 gaactgaaag catttccata tggaaaaatg gttaatcaag tcaatacata tgaagagttt 1604701 gctgacagtg attgcgaact tgtccttttg atagcagata atagctacgt ttcgatttac 1604761 tgtaaaaaca aaaatatcat tgaaaaactt tacttcaatg ctttacagca tgattttgaa 1604821 gacgttcaat ttataactga tgaaaatgac acaagaacaa gccttactgt atgatactca 1604881 ataaaaatta aaggagctag tacatgacaa tgcaaattaa aatcaagtat ctagatgaaa 1604941 cacaaacaag aatcagcaaa attgagcagg gagactggat tgatcttcgg gcagctgaag 1605001 atgtaacaat caaaaaagat gaatttaagc ttgtcccatt aggtgttgca atggagctgc 1605061 ctgaaggtta cgaagcacat gtcgtccctc gttcaagtac atataagaac tttggcgtta 1605121 ttcaaacaaa ttcaatgggt gttatcgatg agtcatataa gggagacaac gatttctggt 1605181 tctttcctgc ttatgcattg cgtgatactg aaattaagaa gggtgatcgt atctgccagt 1605241 ttagaatcat gaagaaaatg ccggcggttg aattggttga agtcgagcat ttgggaaacg 1605301 aggatagagg aggactcggt tcaacaggta cgaagtaaac aaaataaatc cttggctgtc 1605361 ttcatgctgt gtgattgatc aatggaggtt tcagccaagg tacatataaa tattatgtat 1605421 aaaatgaata ttttaatacg aaggatttaa ttaaaaacaa agtttaaaaa gggaagtttt 1605481 gaaaaagtga aatagtaata actaaagtcg ataaagaacc taaagatgtc aaagaaacaa 1605541 tttttctggt gctttgcttt tttgaaggtt tacttagctc gtggataact gccccccata 1605601 aaagcatgga tgctaaaatt ataatactta tatacataaa gatgctcctt ttattatatt 1605661 tacagttttt acatttttat cgattttacc acatttagga ttgagttgtc gatgaaacaa 1605721 gcatctctat aaagaaatac ttttatctaa atttttataa ataggggaag gcaactaaaa 1605781 actagtaatg ccactaataa taagccaagt taaatgactt gtgttcatta ataattgaat 1605841 tttacagcag ccatgagcac aaaaaaatct gagttcgtcg ataaatatca taaaaaagcc 1605901 cccggtatgt cgccagggaa taaatagacg tttaagagat ttagtgatgt tttttatatg 1605961 attcgacaaa atcataataa tgatcatcgt catcataata ctttttttcg taatgataat 1606021 cgtgatcatc gtaatacttt ttatcatggt catcatactt tttgtcgtaa tcataatgtt 1606081 ttttatcatg atcataatac ttgtcgcaat cataatgctt cttatcattg tcgtaatact 1606141 ttttgtaata tgtttttttc caagtataat actcttcttt atatttttta taataaccca 1606201 attaaattcc tcctttatgt tattcgaatt taatttatga agtttaaatg atatggtatg 1606261 gtcaaatgaa ataagaatag taaaaagagg ctgtttaaaa cactttctga aaaacaaaac 1606321 ggatagctgt ttatgaaaat aagagcgaga gagagcactc aatcactgta aaataatagt 1606381 aaagtgtata gagagattag tatacgtaaa aagggacttt ctcattgaag aatatttgaa 1606441 cgttatggtt aagattcaag agctctatga tgtgattttt cacactgctt ttgaaggatt 1606501 tagagttaga catcaaaaac aaacagcaaa accggctaga aacagatcat ataaggaatg 1606561 aaccgctgcc aaatatcata aaaaagttgt taatgatcaa atgaatgaaa ttagagagaa 1606621 tttattttaa agaaagccca attgcacatg gacaaatgac aattgatatt gaggtaaaat 1606681 acaatgcatt aaatcagaaa aagctattgg aggatttaat gtgtttagac aatttccaat 1606741 ttggtataca caaacacctg actatttgaa tttttatgta ccgcaatatc aaaccatttc 1606801 gtataatcct caacaatgtt atcaacggtg tatgtaccaa actggcggta actatgagct 1606861 atgtgacaga ctatgttatg gagaaataca ggtgtaaaag agggggatta actcctcttt 1606921 aaacacacag tgagtggaat aagatcctca ctttatctgc aagtgcttag tatttgcgat 1606981 aatattgcat tcgtaataaa ttatgcttag caactgaaaa tgaaagaagg atatgaatag 1607041 tcatgacgca attcgataaa caatacaatt caattataaa ggatattatc aataatggaa 1607101 tctcagacga agagtttgat gtaagaacca agtgggactc agatggaaca ccggcacata 1607161 ctctaagtgt aatcagtaag caaatgagat tcgacaactc agaggttccg attttaacga 1607221 caaaaaaggt tgcctggaaa acagccatta aagagttgct ctggatttgg cagctgaaat 1607281 ctaatgatgt taatgattta aacatgatgg gcgtccatat ttgggatcag tggaaacaag 1607341 aagacggaac catcggacat gcatatggat ttcagctggg gaagaaaaac agaagtctaa 1607401 atggagaaaa agtggatcag gtagactatc ttcttcatca attgaagaac aatccatctt 1607461 cacgcagaca cattacaatg ctgtggaatc ctgatgaatt agacgcaatg gccttaacgc 1607521 catgtgtata cgagacacaa tggtacgtta aacatgggaa actccacctt gaggtaagag 1607581 cacggagcaa tgatatggca ttgggaaatc cattcaatgt attccagtat aatgtgttgc 1607641 agcgcatgat tgctcaagtg actggttatg agcttggtga atatatcttt aacattgggg 1607701 attgccatgt gtacacacgt catatagaca atttgaaaat tcaaatggaa agagaacagt 1607761 ttgaagcacc tgaactatgg atcaatcctg aagtgaaaga tttttatgac tttaccattg 1607821 atgatttcaa gttaatcaac tataaacatg gggacaagct tttatttgag gtagcggttt 1607881 aatgctgcct ttttattgtg cagtgaatag atagcaggta tcctaatttc attaagcaat 1607941 ctggaagatg aataaaaatt gaaggacaaa cacgtataat acataaaaaa gattaactct 1608001 acagttaatc ttttttattc agaagaaaat atcctaactt tgaaactaaa tacaaagtaa 1608061 aagcaatcat tacagttcta gatattacaa ttccatgaat agctagatca tatccagcag 1608121 gtatcaacgc atttgtatta cacataaaat atatagatat tagaagtgct acaataacta 1608181 aaatcattcc aaaaagactt gttttttcat atttcatacc aatttccacc cttattaaag 1608241 ttaggtttaa acaaaagagc tgaagaaacg aactatgacc agtatgctcc aaggaaaacc 1608301 gccagacaat gctggcggct ttttgctgct tcgtttattt attaacagag atcgtaacgt 1608361 tatttcctgc aactgaaacc tttgcgaaat cctgtgtatc taccacagga gtgacggctt 1608421 tattgtcgat agtgatgttg ttaaaagagg tcgaaaaggt tgctttgatc gcatcacgct 1608481 ggctttcata cgaaacagcc gcggtagcaa gtgttttcca ttttgaaatc gtgccgatgt 1608541 tggttccttg aatttctgtg ataatccgtc cggtgtagcc gtcattgttc gttccccaaa 1608601 gggtcatgcg cgtattgccg cttaaatttt tatagattgt catttggact gtgcttccag 1608661 ggcggaagcc tttattgtat gtgaatttgt cttttccttc gatgtacgtt tcttcatttt 1608721 tggacccaac cttcatgagg ggcttccaga cgttgtattg tttgctgtac tgaagcccga 1608781 tatcggcttc agttccgctt gttgccctaa agccagaata aatataggga gtagagaccg 1608841 agtcgttgtt tttgacagtt tcaggaagca cgattttagc tgtaaaaacg gcgcccgtac 1608901 tgttcaggta gacacggccg ccgattccgt taggcagctc ggatgctgct tttgcgactt 1608961 gagcgtctgc cgcgggtaaa cctggtatac ctgatgaaag ggttccgaaa agaactgctg 1609021 ttcctactgc acctgcaatc aatacttttt tcaccaaaat tccccctttt gatagtggtt 1609081 tcgccattta ttatacctta ttttggaact ggatttacgt atataaatcg acaaaatatt 1609141 tcattttgaa tgatgtaagg tcgaaacgct tcgccaatct gaaagctata tacctttatc 1609201 agaggaaaga atgagatcac attcgtttta accgatttga aattttcctc aaaataaaag 1609261 tacaaatgct taaagaaacg attattaaaa gaatgcccgc tatcgtttcc aagcctgtaa 1609321 aaaagaggtg acgtttcatc aatgtctgtc cttgtaaaat gataaaagca cagataccga 1609381 ctaagaaaag aaaacaaata cttaggattg ctaacgcttt acgtgagtat gttttcattt 1609441 catctttaaa atacagcaat acgaaaataa agcagataac attggctatt gttctaatca 1609501 cctcaaagct tttcatgaca actgatataa atagacaaag taaaatgaga taaaatacga 1609561 tgtttctata caaaaaacct ctccttttat gtaggatcct caaagagttt ataaaagttt 1609621 ctttgtaact gcaataaatt gaatgcgctc acttatgaac taactaaact atgtactaaa 1609681 tattcactat tctttttcag attcagtcac caaggttttc atagaaaggg aagcttcaga 1609741 aatatacata tagtgcacaa acaaaaaaga cccggcaata gccgggggaa agtaaaaacg 1609801 aggagatgtt aatggcgttt agtagtgttt tttatgcttt ttatactcta caacataatc 1609861 atagtctttt ttatcgtgat cataatattt tttatcatag tcatcatatt ttttgtcgta 1609921 atcacagtca taatcttttt tatcatattc gtaatacttc ttataatacg tttttttgac 1609981 cgtataatac tcttctttgt attttttgta ataacccata tatactcctc ctttattttt 1610041 actacgcttt attatacggc gagtagattt tgcggcttgg acagttaaaa tcatagaagg 1610101 aaaaaagggc tgtccaaatg atagaaaaag acagatgaca caaaaacaaa tcaaaataaa 1610161 gagccgattt ttcatcggcc caaacgattt atcctacatt tgtttgtctt ctttgttttc 1610221 tgagtcattt tttctgatat cctgagtcag tccgcttgtt gcttgtttaa attctgataa 1610281 ggcttttcct gctgcacggc caagcgccgg cagtttatca ggcccaaata ctaaaaaacc 1610341 cacaaacaaa ataacgagta tttttgtgaa gcttaattcc atatcctttt ccccctgatt 1610401 gaagtacaac cttttaaaca aattataaga gatagcagta caaatgggaa tgcatttatt 1610461 ttgaacattt taaaaccagc acaaagacgg attcataaaa cggctgctgc tgaatataat 1610521 gtccaatgcc acctgcctaa gaagcaggag gcaggctgga tcaattatgt agctctgccg 1610581 gaaatgatac aaacgtagcg gctatcattg acatagagga gtggtgtagc tgatgagatt 1610641 cactaaggta gttggatttt tgtctgtttt agggttggct gcggtttttc cattaacggc 1610701 acaagcagaa aaagccggaa ctgcgggggc tggagagtgg gataagttgg ggacttacac 1610761 atatacttac tcaagtccga cggtatactc gaccggagga gattttagag tgtgcctttc 1610821 aggaagcact cctttttctg tttcactgca cttatatgag gatgatcccg gtgacaatcc 1610881 tgatgattat gtaggggcaa actatttttc acccggagaa tgccacacct ttggcagtat 1610941 tggaaaattt gtagatggga gcaataacaa ggccgagttc tttgttaccg attactctgg 1611001 taaatctaaa actgttacgt tttatgattg atggactcaa attgtgaagt ataacccttg 1611061 gaaaaaaaca aaaaagagag atacctctct cttttttatt cttcgacagc cttacgaagc 1611121 cgttcattta caatgccagt ccagccgcca tccatcttac cgcgaacgac ggagcttttc 1611181 tcgtttgctt tgccgatcac ttcattcggc tctttccagc cgctgtgaat aagggtaaac 1611241 cctgtctttt cccccaagtc ttctaattga aaggtaacga cccatccttc tgtatcccat 1611301 tcaaaagaaa gttcagttgg agcttgaaca gccaaaactt tacaagggga cggcccaaac 1611361 ggcgattgta agtgaaattc ttgtccttct ttgagctgaa agtcattggg cataaaccac 1611421 ttggcaatgc cttctgaagt agagactgtc tcccagactt tctgaatggg agcctccaga 1611481 gtaatgcttt ttgtaatatc cggtaatgca ttttcgttgt tttgagccat ttcgtttacc 1611541 tcttgacata tgatgttttt tcaattcaat catataataa ctaataagat catgtccata 1611601 gcgtgcatta tttatgctag agctgctgtt gaacagcgtg tcagtcgcca gtctgatctg 1611661 tgaatgggag aattctgcat gcgcgaaaaa gagagagagg tgtatgttgt catttcgttc 1611721 attcttgttt gcagccgcaa ctgttatgtt tgaactggga ttcctgttca gccaatttat 1611781 tttgcgattt ttgttttaat agtaaatgag ccattttcta aaacaggagg ttttttatgc 1611841 ttggaaaaat caaagcagcc attgataata gtccagggaa gccggccaga attttagtta 1611901 gtgaaaaagc gtttcagcaa ttagaggaag aaatgcgctt tgtttacgtt tccaaaccga 1611961 aaacgataat ggggattcct gtggaagttt cagatcaggc agaaagcttc aagctggaat 1612021 tttagttttc ccagactgct aaaaggctca ttttgtgtta attatgcaaa atggtcaggt 1612081 tgatttcttt aaaagcatga tgaaatgttc atcatgcttt tttattgaga aaaaagacga 1612141 acataaaaaa taggtatacg ggaaaaataa tcctattaga gagaggggaa ctgacagatg 1612201 gataacatga tatcaacact tactgactgg aatgtgtggt ttcaagcgtt agtagtattt 1612261 ctcgttccat atgtaatcta taaagtgttt acttggattc atgtataaga aggtgcaatg 1612321 atgaggtggc ggaacaatca gtacaaaaca cagaagcagc ataaatcaga ttattcgaca 1612381 gctgaaaagc aggatcagga tgtgttaacc ggtaacatcg gatacgactt agaacatgta 1612441 aaaagaaaaa taggacataa cggggacgtt catttccgtg agcttgaaat cactcaatta 1612501 catgtgaaag cggcattgat ctttgttgaa ggactgtctg atcaggactt gattaataaa 1612561 ggactatcag tgttagtcat gaatcaacct aatcaggtaa gcgatgaaat ttctcaatcc 1612621 ggcaaaggta ttttaacttc gaaacagata aaaaatcaaa tcgtatcaat cggtgatgtc 1612681 atagattcag agaaaatcag tgatatcgtg ttgaatgttt tcatgggttc gacagcgctt 1612741 ctcatcgatg gaataccgca ggcctttctt ctgggaactg taaaaaaaca aaatcgaagt 1612801 atcgaggagc cgctttcaga agcgcttgtc agagggccgc gcacaggctt tacagaagag 1612861 ttgagtacga atacagctct tttgagacag caaggaaaaa atgatcaatt aacattgcag 1612921 agatttgaag taggaacacg attaaaaaag gatttaatta tcgcttatat gaatgacatt 1612981 gcagatccaa aagtagtcga ggaagtaaga aaaagagtga gagggattga gatcgatcat 1613041 ttgccggagt caggctacgt tgaacagtta attgaggata attatttgag cccgttcccg 1613101 caagtacaga gtacagaacg tcctgatcgc gtcataagcg gattaatgga aggaagagta 1613161 gctattctgc ttgacggcac tccgtttgct ttgattgttc cagtcacttt cagcatgatg 1613221 cttcaatcgc ctgaagatta ttatgaacgg tggttcccga gctcgctcat cagattgctg 1613281 aggttcatcg cagcaatgat aacgttattc gcacccgctt tatatatatc atttatttct 1613341 tttcatcctg ggttaattcc gaccaagctg gcgatttcaa tttccgggac gcgccaaggt 1613401 gttccgttcc catctctgat tgaagcctta tttatggaag tcgcgattga aattttaaga 1613461 gaggcggggc ttcgtttgcc aaaaccaatt ggacccgcaa taggcatagt tggcggatta 1613521 atcatcgggg aagcagctgt gcaggcgggg attgtcagtc caatcatggt cattgttgtt 1613581 gcgctcacag caatttcttc atttgccatc ccgcattata gcacaggtat agcacttcgg 1613641 atgcttcggt ttggcgcgat gttttgtgcg gcggtgtttg gattgtttgg agtcattatg 1613701 tattatctgc tgctaagcag ccatgtcgta aagctaaaga gctttggtgt gccatacgca 1613761 agtccggcag tgccctatca cttaaaagat tggaaagact ttgttatcag aatgcctctt 1613821 ttagtcatga agcgccggcc taaaatgatg aatacagata atacaaaacg ggtgaagtga 1613881 tgaactcgac aggatggtga taaagtctca tgttcagccc aaccagtaaa atcacaaccg 1613941 ctcaggcaac gattatcatc attaattata tgcttgctgc cggagttctt acgctccctc 1614001 ggacagtaac agaacaaaca caatctcctg atggatggat ttcagtttta ttaggcgggg 1614061 tcctagcggt aatagccggg atgattatag ctaaattaag ccagcagtat cctaaggaga 1614121 ccttttatga atactcccga catattgtag gaaaatggct cgggcatctg atcagtattg 1614181 tttttattac ttattttctg gcactcggtg catttgaagt cagagtcatg tccgaaatcg 1614241 tggatttttt tctcctcgaa gggacacctt cttgggccat cattatgaca gttctttgga 1614301 ttgggcttta ttcaattaca caaggcctag atccgattgc acggcttttt gaaatgattt 1614361 ttccgattac ggtcatcatc tttttaacga tagccctcat gagtttaggc atatttgaga 1614421 tcaacaattt gcgccctgta ttaggtgatg gaatcatgcc ggttcttaga ggtgtaaaga 1614481 caacgaacct ttcatttaca tgttcagaaa ttatgttcat tttagtagca tttatgaaaa 1614541 agccgaaaaa tgcggtgaaa gcagttgtga tcgggacagg cgttgtgacc agtttttata 1614601 tgattacgat gattatggtc atcggtgcac tatcagttga gggagttgtg acgagaacat 1614661 ggccggggct tgacctgatg agaagttttg aaatacctgg tttaatattt gaacggtttg 1614721 aatcatttct gcttgtgatt tggattatgc agctttttgc cacgtttatt atcacttttt 1614781 atgcagcttc cctgggagtc tcacaagttt ttaaaaagaa acccctttca tgtatgtttg 1614841 ggctgcttcc tgttatatat atcctctctt gcatgccgaa aaatgaaaat gacgtcttta 1614901 tattgggcga tacggtcagt catatcgctt tgtatatatt tggcgctttg ccgattttgc 1614961 tgttagtcat ttcgaaatgg aggaaaagag gtgaaaagta aactaaaacg tcaattgcct 1615021 gctatggtca tagtatgtct gctgatgatt tgcgtaacag gatgctggag cagtcgggaa 1615081 atagaagatc tgggtctcac attcgctatc gcaattgata aaggaaaaga aacgaacact 1615141 gaaaaagagt taaaagaaga gggcgggagc tatccgaaaa aagacaacat tacgctgacc 1615201 tatcaatttg ttaatgaaaa agcggcaggc gcgggcacaa gcgggggagg cggtagcgga 1615261 caaggagcgc aaaaagcgta cattaatata agtgaaacag gggattcatt acagcagatc 1615321 ggaagtgagg ttgcattaag acgggaccga gaagtgttta gcccgcattt aaaagttgtt 1615381 gtcatgagtg aagatgtgct gcacacattt cctatcgacg aaatgctgga tcaatttttt 1615441 cgtgataatg aaatcaggct gagctgtctt gttttatctg ctaaagggga agcaagagac 1615501 gctctccagc tgaaagagaa cggagaaatt ccggcatttc ggctgattgg attaggtgaa 1615561 aatgaacata aagtttccag aattcttccc cctatgacac tcgcgaaact aattggaaaa 1615621 ctgcattctg gcagcagctt tttactgcaa aatgtggttg cggcgaatgg agcggtcaag 1615681 tattccggag cagctgtaat caacggaaaa tcgaaaaaaa tgataggcac cttaaatgaa 1615741 tatgaaactg aggggattac atggattaga ggagaaggga aaggcggagt tgtcaaaagt 1615801 catgataaaa agagccaaca gacgttagcg tacgatatca ataaaatcaa aagcagaatt 1615861 cagccaatcg taaaagggaa agatatttca ttccatgtcg atattgaatc agaaggcgat 1615921 ttggttgaaa actggaacac aaaagaggcg ttggacaccc agtttataga tcgtctcgaa 1615981 acgactattg aaaacgaggt aaagaaaata gttggtcagg tattaaaaaa aattcagcat 1616041 gattataaag cagatgttgc gggttttgat gaatctttta gacttacata tcctcactta 1616101 tggaaaaggg tgaaaaataa ctgggatgac accttcagta aagccgacat cacatacagt 1616161 gtgaacgtca caattactca tttcggcacg gttaaaactc agtaatgaat cccaaggaag 1616221 agaaggaaac ctctcttctc ttttttatgc atttattagg ataaagatac tttttttgga 1616281 gagatataca cttttcaaat cgaccaatat gctaatatag gaattgcttg aaatagaagg 1616341 gagaaggggc tgtgaggcag aaaccgattt atgtagaaat cgaaatgaaa tctgatctgg 1616401 atacactctg ggaatataca caaaacccat cactgcataa ggaatgggat ctccggtttt 1616461 caaatattac gtatttgaat agtcagccat gcgaaaaaca gaagtttctt tacgaaacaa 1616521 gggtaggctt tggattaaag gtgtcaggta caggagaaac cgtcggtgtt ttcaacaaat 1616581 gttcatctga aaggtcttct tcactggctt ttggctctga tcatccatta tctctgattc 1616641 ggcatggaag cggctactgg aagtatatac agagagaaaa tgggaaaatg acgtttttaa 1616701 cacagtacca atacaaaaca gcctacggac tgctgggaag atggattgat cgtttattat 1616761 ttcggccgct gcttggctgg gcgactgcct ggagctttga tgcattaagg ctttgggtag 1616821 agcaaaataa acatccgaag cgcttcattc gatctgctat catctatgtg ttcatgtgtc 1616881 tgtttttcag cctgttttgg ttctatcaag gctttgcagg tgttaagaca agcatattga 1616941 caggaacagc ggagataggc ttagctattt tgtggctgct tcctttaaaa agaaaatgga 1617001 tcattcatgg tgtccaggct tgtatttttg ctgggtttgc ttgtctaggt tccgaaatat 1617061 tcatgtgggt tctattgagt gtgttttccg ctgcaagcgg cgctcttagc ctgcagctcc 1617121 ccagtgccag gcgcacaaaa cgaaagagaa agaagtgaca ttgtgagttc gatttatgaa 1617181 aaatcaatta ttaactatca tttgctgcat cccaagctgc agaaacggta ccaattagac 1617241 gggtctcata cattcagcgg gacgggaacg atgtcagaaa taagcggagg ctcttttctg 1617301 gttagaatgc tgttaaagct gggtgttttt ttcagatgct tcttttcaga aagaggcaaa 1617361 gacattccat ttacaataca aaatagaact tgtcttttga aatcgcaaca tacaggaata 1617421 gaatggaatc gtacattttt ctttaaaggc aaaaaacgtt tctttgatgc gttaatgata 1617481 tatgacgaga aagaaaatag aatacttgat ttcttcggca aacctcatct gctgctgtct 1617541 gttttgacgt tcgaggcatc tcttgacggc tctcttacga tcacatcggg aaagcaatgg 1617601 ctattgatat gcggaaaaag aatcccgctg ccgaaatggc tgaccggtac atccgaagtt 1617661 tgcgaaacgt ttgatgaaaa aaagaattgt ttcaccattg aagtgcatgt gcaaaataca 1617721 attcttggca ctcttttctt ttataaggga acgtttcagg aggaagagag agaatcatga 1617781 aacgaaatgg catagtcagt gcgctttgtt ttattggatt tcttgcagca gaagcaccgg 1617841 atatttcagt ggcagaggca ctcgttttgt tatccattct atttttcgtg ccgggaattt 1617901 ttccttttgt ttttcgtcaa tctccggttc gtgctgctca gtttatggaa aacgggctaa 1617961 tccagtgcta tcctgtagcc gcattctttg cggtgctggc tctagtgacg gaggttgggg 1618021 gtttcgcact tatctggtgg atgtacacag tttttaatgc attgtatgcg atcctccgcc 1618081 tttgggaaac aaagatacat agaatcgaag agacatcagt tttgttcggt cttatttatt 1618141 tggcgggagg aggattttgg ttttttgctt atgctgccca tttgcagatc atgcaatttg 1618201 gccctctcat cattttgctg actgctgtcc actttcacta ttctgctttt ctgatcccga 1618261 tcttcaacgg tttactcggc agaaccatta gaaaacatcg gatgttgtac agttggataa 1618321 catgggtgat tttgctttcg ccccttctta tcgcactggg catcacatat tcaaaaacac 1618381 ttgatgtcat tgcggttagc atttatatgg cggcgattta tcttcatgca tttttggtgt 1618441 tcacggcagc ttttcgcacc aagacgggga catttcttat tcggctttct tccgctgttt 1618501 taatgataac gattgctttc tcgatgattt attcatttgg tgtctttcgg caagaagtta 1618561 cattgaccat caatcagatg atttggattc acggttttgt caacgcgttt ggtgttatct 1618621 tgcccgctct catagggtgg agaatagagg atgcgaaacc ttttgatgca gacagtgtaa 1618681 agacattcag ccgtatctac ggaaaaagaa agattggaga agaattttta gctaacattc 1618741 aagctgaaaa taacgctcgg tacagcggac ttgtggatga tatgggcagc ctgcgttcaa 1618801 aagatttttc accagaaaaa ctggcgccgc tcattctttc gttttatgaa caaaccatcg 1618861 aatacaatat taaagcaaaa gtaacatgga gcacgtggtt tcggccgctt gcaattattt 1618921 acgaatggtt cagcagaaga atcggccaaa tacatctttc gacgaaccct gactggtata 1618981 ggatgtacag caagataaaa ggtgttcatt cgaaaaaaga cggaagggaa agagtacgtg 1619041 cctggattag aacaaatgaa aaaaacgaaa ccatttttac cgctctttat tcagtgtatc 1619101 gttcaaatgg agaggggtat atgaatattt ctttaccgct tccattcagc agcatgacag 1619161 gtattttaaa accatatcat catcaggaga agctggtttt aacaagcagg cggagaaaaa 1619221 gcagagcggg ggatgagggg atttatctgc aaacaagagc gggaacttgt ccgcttcctt 1619281 tatctgaaac ctttctgata gaagctgtac atgacaacaa attaaccgct gttcatcata 1619341 tgtggctgtt tggaataaaa tttctaactg ttcattacag cattacacat attaaccagc 1619401 ctattgaaag aacctaacac aaagaagaag cttcgtctgc cagttgtaat gagatgaact 1619461 gttttaaaat tctgcaccgc atcaagacag gaaaggaagg gtttatggtg ttttatatca 1619521 gtttatttct gattctttgg ctggctgctg ggtttgcagt gggaatgaaa caagtgtatg 1619581 tcgatcagct gtttgataaa gctgtgatcg aaagactgga aaaagaagcg aatgatcatg 1619641 gacatgctga ccggatgatc aaacagcgcg tcctttatat tgcagcagtg acagtaagcg 1619701 ggtttatttc tgtttattat gaaatgaaaa caatcccgca aaggcgaaac ataagaaaaa 1619761 ttgaaaaaaa catcatgaaa ttaaatcaag caaaaaaacg aagaatgaag agaaaataaa 1619821 aagtgcacag gccaaagggc aggtgcattt ttgttttgta tggaaaatgg gggaggtggt 1619881 gccagcttac ttttcataaa ttcaaaaatg agaagaacag cgcccgggct aatggtatat 1619941 aatattgtga atttaacaaa aatttaacaa ggaggacgag agaattcgtg ctaaagcctc 1620001 aaagagacct acattctgtt gatttggact tagaggcgga gtagatgaaa ccggccaaag 1620061 tatccctgct ccgccgtttg ctccattcct tgaagcatgt tgattgtaac atagccaaac 1620121 gttttccatc aactattaaa attgtaaaat tattgatgat ttttatggtg tttactccga 1620181 tttcttcaat ttatgctgaa gatgtatatc agaattttga ggaattaaaa aacaatgaag 1620241 atccttctga ttatggcgtt gttacgaaag aaaccggaag ccctgttctt gttttagcta 1620301 ttcacggagg aggtattgaa ggcgggacaa gtgaagtagc gagagagctc agcaaagagt 1620361 actcgatgta tttatttgaa ggcttaaaat cggcaggaaa ctcagtcctg cacattacga 1620421 gcacacactt tgatgaacct cgggccctta aaatgacggg aaatcatgaa tatgtcattt 1620481 cattacacgg gtacgcagaa gaagatcagc agatcgaagt cggcggtaca gatcgcgtaa 1620541 gagcggcaga tttagttgag aaattgcagc atgccggttt tcctgctgta ttgctcaata 1620601 tggaccatcc gcatgcgggc gttagtccga ataacattgc aaataaatca aaaacaggtt 1620661 taagtattca gatagaaatg agcacagggt ttcgaaagtc tttgttcggc atcttttctt 1620721 taaaaagcag agctgttact caaaatgaga ggttttatga gtttacagaa gtgatgttcc 1620781 gttttctcaa aaatagctac tgaaaaatag gaggcgataa gacagcctcc tattccttat 1620841 gcttctcttt cgtttcggga aacagctcgt ccgcggcttc cgtttgatac tgcaacgtgt 1620901 tatctctcgc tgacagttca tttcggaaat tttcatcaag cacatttttc agtaaatacc 1620961 gatgaaaaaa gtattcaaaa acagtaagac aggcagcgga aaggagagcc gctccaaatg 1621021 gtgagaaatc gtttcttgtt tgggttaaaa caaataccca aagaataacg aatgaaaggc 1621081 caaagtcagc caatgaagct gtaatattgt ttgttctggg taagacgagc atgtcaccag 1621141 aaagatagga aacaaaacct aagaaaagtg caataaacat cacacttaaa aaggatgcgt 1621201 gatagactct gtccaaaatc acatataaaa gggcgagagt gaaagcaatc tttgaagcaa 1621261 gcgcaatgat atgtttcatt tgaccaccta aattgttatt ttttgaagaa aattcttggg 1621321 cgtaaacaaa tgataaataa tgcaattcaa aaccattcat aatggtcatg ttactatttt 1621381 aaacagtccg tttttgttta cactggtatt tttttcagct gtatgaaact ttcttatgaa 1621441 aaaagtcgta tatgtggatg atcagctttc aaggggggaa tgatttgtgg agataaaagg 1621501 aatcaatcac ttgctatttt cagtttcgca tttggataca tcgattgatt tttatcaaaa 1621561 agtgtttggt gcaaagcttt tggtaaaggg aagaacaact gcatattttg atatgaacgg 1621621 catctggcta gcgcttaatg aagaaccaga catcccgaga aatgacatta agctttctta 1621681 tacccatatt gcttttacaa ttgaagatca tgaatttgag gagatgtcag ctaaattaaa 1621741 aagacttcat gtcaatattc tgcctggcag agaacgagat gaacgcgatc gaaaatcaat 1621801 ttattttacc gaccctgacg gccacaaatt tgaatttcat accggaaccc ttcaagacag 1621861 gcttcgatat tacaaacaag aaaaaacgca tatgcacttt tatgatgaaa cggccttttg 1621921 atagcacaac catatttcat ataaggttaa atttaaagaa gggtgttggt ggagacttta 1621981 tgtttgggga aggtttctac ccgacttgtt caacgatgcc atatcttttg aactgcacaa 1622041 gtgattgggt gaaggtgaaa ttgaaataca cattacatta cattttatat gaagaaagcg 1622101 agctgtttta tcaaatgttg aactaattaa actatgtact aaattttcag tatatttcaa 1622161 ttgctttgcc ccttaataaa tataaaaccg catccttcca cgacctaaaa aatgaaacgt 1622221 ttttaagaag atggcgtcta atattctaaa tgttcatatt ttgataaaag tttcctaaag 1622281 gaaagaaaat ttcttgactt caacaatctt ttggtggata attatggtgt aaacatgatg 1622341 ttctttttcc tcctattcgg gctcgcaccc aaaagtcagg gcgagcctgc tttttttgaa 1622401 caacaaaccc cctctccgta aaggaagagg gggttatttt atgcatctga tagatcaata 1622461 gattaatgga cggttctgaa cacgccaatc actttcccta gaatgctgac attctgcaaa 1622521 atgataggtt ccatcgttgg gttctcaggc tgcaagcgaa tgtgggtatc ctctttatag 1622581 aatcgtttta cagttgcttc atcatcttct gtcatcgcaa ctacaatttc cccattgttc 1622641 gctgtgtttt gctgtttaac gatgacatag tccttatcga gaataccagc atctatcata 1622701 ctgtctccca taatctccag cataaataca tgctcgtctg gaggaaccat gcggtcaggg 1622761 agcggaaaat attcttcaat attttctact gctgtaatag gagatcccgc cgtgactttc 1622821 ccgatgaccg gtacattaac gacctggctt tgcggaatgt ctacttcttc atcaagaatt 1622881 tctattgctc ttggttttgt cggatctcgt ctgatcagcc cttttgtttc caaacgggcc 1622941 aaatggccgt ggacagtaga actggacgca agcccgacag cctctccgat ctctctcacg 1623001 gaaggcggat atccttttga tttaacctct gctttaataa aacggaggat atcaagttgc 1623061 ctttttgata gcttcgtcat ttttcgcacc tcaaaacgtc gattttaaga agattatagc 1623121 atgattttcc ttacagtaca aacataggtt cgaaaaaaca attgacagaa acgtttgttc 1623181 gtatatactg aaattataaa aatgcgaaca aacattcctg ttggaggtta tgatcatgag 1623241 taaagaatct attatttttg tcggtctgtt tacagtgatt ttgagcgcgg ttatccttat 1623301 gctgtcatat acaagcagcg gccaagagct taatcagtat gttaaaatag aagtccagca 1623361 aggcgacaca ctctggtcaa ttgctgatca ggtagccgat acaaaaaaga taaacaaaaa 1623421 tgattttatt gaatgggtag ctgataaaaa tcaacttcaa acctctgata tccagccggg 1623481 tgatgagtta gtgatcccat tgaaaaagaa gcatcaggat gcatatgaat tagcaactgt 1623541 aagatagaga ggaaagagag ataaaatgaa agcactcatt tatgcccgtg taagcacaaa 1623601 taaagaacag caggaaacgt cattaaagcg gcaggaggag gagcttacgg ccattgcagc 1623661 ggagaacggc atggaagtgg tcaaagtgat ttcagaaaaa gccagcggat atgaaatgga 1623721 tcgggatggt gtatttgagc tgctcgatga gattaagaac gctgatattg atgtcatttt 1623781 ggttcaggat gagacaaggc tcggacgggg aaacgcaaaa atcgcactgc ttcattgtat 1623841 ttatagagaa ggtgtgaaag tctatacaac ggctcataga ggtgaactgg agttatcgga 1623901 ggctgactca atggtcttgg aaatcgtcag cattgtggaa gagtatcagc gaaagattca 1623961 caacatgaaa atcagacggg gaatgaaacg tgcagtaaaa aacggtttta aaccgcaaaa 1624021 aaacttaaaa aaccaacatg ggaacagtgg aaaagaaaaa atagaggtgc caatctcaga 1624081 gatcgtccgc ctgagagcga ataaactgac gtttgctgaa atcgcggcta ccctaagagg 1624141 gtttggctat gatgtctcta aagcaaccgt tcaccggcgt tttcaggaat acatagagaa 1624201 tgaagagact gcagagtgaa tcagttgtaa aacttttttt gatctagtac tatatagaca 1624261 aaatgcaata aaggagttta acatgatttc aaacgcgaaa attgccagaa ttaatgaact 1624321 tgctgccaaa gctaaagctg gcgttattac agaagaagaa aaagccgaac agcaaaagct 1624381 ccgtcaagag tacttgaaag gttttcgttc ttctatgaag aacacgttaa aaagtgtgaa 1624441 aatcattgac ccagaaggca atgatgttac accagaaaag ctaaaaagag aacaaagaaa 1624501 taacaaactt cactaatata agaggaatac ggcaatatcg tattcctctt ttgcatatac 1624561 tataatcaaa actcttatgt gacaaaattc aacaagtttc tctcaaattt aagctgaaac 1624621 agttgagaaa aagtcgtcag acatttatga tgtaagggta caacacataa ggaaggggat 1624681 ttttatggat acaattgaaa agaaatcagt tgctaccatt cgcacactgt caatagacgc 1624741 tattgaaaaa gcaaattctg gtcacccagg gatgccgatg ggagccgctc caatggcata 1624801 cacgctgtgg acaaaattta tgaacgtaag tccggcaaac cctggctggt ttaaccgtga 1624861 ccgttttgtt ttatctgctg gacacgggtc agcactatta tacagcatgc ttcatttaag 1624921 cgggtttgat cttagtattg aagatcttaa gggattccgc cagtggggca gcaaaacacc 1624981 aggacatccg gaattcggac atactgccgg tgttgatgct acaacaggtc cgcttggcca 1625041 aggaattgcc atggcagtcg gtatggcaat tgctgaacgc catttagcgg aaacatacaa 1625101 ccgcgattca tttaacgtag tcgatcatta tacatacagt atttgcggtg atggtgattt 1625161 aatggaaggt atttcttctg aagccgcttc actcgcaggc catcttcagc ttggccgtct 1625221 gatcgtacta tacgattcta atgacatctc tcttgatgga gacctcgacc gttcattctc 1625281 tgaaaacgtg aaacagcgtt ttgaagcaat gaattgggaa gttctttatg ttgaggatgg 1625341 aaacaatatt gaagaattaa cagcggctat cgaaaaagca cgccaaaatg aaaagaaacc 1625401 tacattaatt gaagtgaaaa cgacaatcgg attcggttca cctaaccgtg ccggtacatc 1625461 cggtgttcac ggtgcgccgc ttggtaaaga agaaagcaaa ttaacaaaag aagcttacgc 1625521 gtggacatat gaagaagact tctacgttcc gtcagaagtt tatgagcatt tcgctgtagc 1625581 tgttaaagaa tcaggtgaga aaaaagaaca agaatggaat gctcaattcg ctaaatataa 1625641 agaagtttat cctgaacttg ctgaacagct tgaactggca atcaaaggag agcttccgaa 1625701 ggactgggat caagaggttc ctgtgtatga aaaaggaagc agtttggcat cccgtgcatc 1625761 ttccggtgaa gttctcaacg gacttgcgaa aaaaattcct ttctttgtcg gaggttctgc 1625821 tgacctagcg ggatcgaaca aaacgactat taaaaatgcc ggtgatttta cagcggttga 1625881 ttactcaggc aaaaacttct ggtttggtgt acgtgaattt gcgatgggtg cggccttaaa 1625941 cggtatggcg cttcatggcg gtcttcgtgt attcggcgga actttctttg tcttctctga 1626001 ttacctgcgt cctgcgattc gccttgcagc gttaatgggc cttcctgtga catatgtctt 1626061 cacacatgac agtattgcgg ttggtgaaga cggtccgacg cacgagcctg ttgaacagct 1626121 tgcttcactc cgtgcgatgc ctaacctttc tttgatccgt ccagcagacg gcaatgagac 1626181 agcagcagca tggaagcttg cagtgcaaag cactgaccac ccaacagcgc tagtgcttac 1626241 acgtcaaaac cttcctacca tcgatcaaac atctgaagaa gcattggcag gagtagaaaa 1626301 aggtgcatat gtcgtttcta aatctaaaaa cgaaacacct gacgctcttc tcatcgcttc 1626361 cggatcagag gtaggtcttg caattgaagc gcaggctgaa ttggcaaaag aaaatatcga 1626421 tgtttctgtt gtcagcatgc cttcaatgga ccgttttgag aaacaatctg atgaatacaa 1626481 aaacgaagtc cttcctgcag atgtgaaaaa acgtcttgca attgaaatgg gctcatcatt 1626541 tggatggggc aaatacacgg ggcttgaagg tgacgttctc ggcatagacc gattcggtgc 1626601 atctgctcct ggtgaaacca tcattaacga atacggcttc tcagttccga acgtagtgaa 1626661 tcgagttaag gcattaatca ataagtaagc ttttgaaaga ggatgagtca aatcatcctc 1626721 tttttcttgt ttatccgaca aaaatagtat tggctgttta acagtaatag acaattcttt 1626781 cttttcttct tttgtataat agagagcaaa tgaaatgctg ctggaaaagg ggatgaaaag 1626841 atggaacgtc actactatac gtacctgatc aaagaggaat ttgccaatca ctatttcggc 1626901 cgggaatcgg ttatgtttga gctgtttcaa gactatcatt ggacaagcct tgaaaagcag 1626961 cagtatgaaa tgacagagaa acagattcaa tatattacac aaccaatccc gattttacat 1627021 atgcatcagc ggttaaaaat gaatttaaac aagacggatt acaggcagct ggattatatt 1627081 tatagaatag ctttgccgaa agcaaaaggc cacgcgacgt ttatgatgaa ggagcacatg 1627141 atagaaattg tggcttcggg agattacgag gcagaaacga tattctttga agtgttaaga 1627201 aaagtaagcc cttgcttttt agcaatggat ttcaattcga agcgttacgg atggctaaat 1627261 ccggtgaaag aaagaaattt tgtctaaaac cgaagaaaaa gagatgtaaa tgttgtataa 1627321 tagcttttgg tttagtacac tttaaactag acaacatgaa ggaggaaata aaatgacttt 1627381 atgggttggc atcctagtgg gcgttgttgc attgctcata ggtgttgcac tcgggttttt 1627441 tattgctcgt aaatatatga tgagctacct gaaaaagaat ccgcctatta atgaacaaat 1627501 gttacgcatg atgatgatgc aaatgggaat gaaaccttct caaaagaaaa tcaatcaaat 1627561 gatgaaagcc atgaataatc aaacgaaata atacgtaaag attatgatat agagaaacat 1627621 ggttataaaa taaaaaaccc ttatacgggt tttttatttt gcaatcattc atcacccgct 1627681 actgctcgaa ggcgctgctt ttgatattgt atgagaagat ggtcaagctc ctgactgagc 1627741 tctatcgtaa tatgagatgt cattccgttc gccatgacaa tttgcagcag ctctgctctt 1627801 tttttttcaa tttcttttaa tagatgctct ctaatcacag ggatgtatcc tttcatacat 1627861 tagatcttca aagtgaatgt ttatattata tccatattta tactaatttt caaatgagaa 1627921 ggagtataat gtctcaatgt caaattaaat tatataagtt ttttctgaaa atagaaatcc 1627981 ttcaagtgaa agtgttaaaa aaatgaaatg attttgtcat aacttgaagg aatgtcaaat 1628041 catgaaggga tgatgacatg ggagacgtga attatttttt gacattcgga gcggggtttt 1628101 tatcctttat ttcgccttgc tgcctgccgc tttacccagc ttttttgtca tatattacag 1628161 gggtcagcat ggacgatgta aaaactgaaa agctgctgct gcagaaaaga agcttgtttc 1628221 atactttgtg ttttttgctt ggcttttcag tcatttttat tgctttaggc tatggaacat 1628281 cttttattgg cagcctgttt agggattatc acgatgcgat tcggcaaatt ggcgcgttgc 1628341 ttattatttt gttcggtttc attacactcg gtgtgttccg gcctgaggct atgatgaaag 1628401 agcggagaat ccattttaag cataaaccaa gcgggttttt agggtcggtc ttaatcggaa 1628461 tggcatttgc agctggatgg acaccatgta ccggtccgat attagctgct gttatcacac 1628521 ttgcaggcac caatccgggc tcagcggtgc catacatgat gttatatgta ctcggttttg 1628581 cggtaccgtt tcttttattg tcttttttta tcacaaagct gaagtggata aggaagaacc 1628641 agcttttcat tatgaaagct ggtggcgttt tgatgattgt gattggtgtg ctgttattct 1628701 ttaattggat gagcctgatc attattttgc tgtcagatct ttttggaggc tttactggtt 1628761 tttgacggta aattactttc gtactactac taatcctttt gtttttggta caataagact 1628821 attatctgtg gaaatcgatt gttggagggg aatatgacaa gagttttagt tgtagacgac 1628881 gccaagttca tgagagtgaa aatcagagag atcttggaag aggcaaatta cataatcgca 1628941 ggcgaagcgg cggacggtga acaagcagct gacctgtata aaaaactgcg cccggacctt 1629001 gtgacaatgg atattacaat gccggtgaaa aacggcataa aagcgcttcg tgatatctta 1629061 acctttgatc ctaaagcgaa ggtcatcatg tgcaccgcca tgcgccagca aagaattgta 1629121 acggaagcaa ttgagctggg ggcaaaggat tttattgtta agccgtttga ggaaacaaaa 1629181 gtgctggaag ctgtaagccg cgttatggga cattaaagtc atttcttttc aaaatggttt 1629241 tttttattgt tttggagtat agtatatagt atcaacactc cgagaaacaa aggaatgata 1629301 agtatgatga ttatagtttc atcaattatt gctgtgttaa tggctgtagc tgtgatggtg 1629361 gtcagaataa agtcctctga caagcctgtt tcaccaaaaa aaatcattct tccgccgatt 1629421 tttatgagta cgggagcgtt aatgttttta tttccggtat tttgggtaac tggagcagag 1629481 tttttggaag cattcacttt aggtgtgatt ttctctattt ttctaatcaa aacttctaag 1629541 ttcgaaatta aaaataatga aatttacatg aaacgctcta aagcatttgt ttttatatta 1629601 gtcggtcttt tggtgatcag aatcgtgatg aaatcgatct tgagcacatc aattgattat 1629661 ggtgcactga gcggaatgtt ttggattctg gctttcggta tgattgtgcc ttggagaatc 1629721 gccatgtatt tatcatatcg aaaacttcat aacgagctgc agtcatctaa tattcaaatg 1629781 aattaaaaaa cctttcctct tgtcaggaaa ggttttttat ttgagaaggg tctgataagg 1629841 ttccaaatcg atttttttgt cccgcagatg cctttttaag aaggtatggt ctcttttagg 1629901 agttgcgaga atatagcctt tgatcataag ttgctgatca atctttgcta ccttttcttt 1629961 taatgcaagc tcaccgattt tgcctgcgat tttagctttt gctgcatctc tgaacagctc 1630021 tggcacgggc gcagtcaatt catctagaaa ctgtttgttt tcatcgttcc ataaatgtct 1630081 gctgttttca atatagtaat cctgccaatc aagctctgat ctgccgtcct cttttggtaa 1630141 acgctttaaa aactttcgaa acatgaaaaa accgccgatt gataataaga ctaccatcat 1630201 gattacccaa aacagaataa accataaaaa ccatccttcc agcatcaatc attccccctt 1630261 attctaacca tattgtatac gaagagagat tagaagaaca cagtaaaaaa agaatagaaa 1630321 aaagtgatag acgtctagtc aaaagagata gtagatcata ttctattgta tagtgaatct 1630381 gctatttggc catgggagag tcactagagg gtatttgacg ataaatggac ggaaaaaaag 1630441 tcactttcat aataggggat gaaagtgact ttttatgttt agctgagagg aaattgaaga 1630501 gaaaaagaag agccatcttc tgtttcttta ttgacggcga ctgtgagtat ttgattttcg 1630561 cattcgactt gaatgttttt gtcattaaaa taaaaaggaa gcatcatttg tttttcaaaa 1630621 gtctgtcctg acgatttgac agttaagatg aactcgcatc cagaaagggt aactgttact 1630681 tgtgtaggct gtaaaaaagt cagatccgct tctataatat actgctgact tgtttcatat 1630741 aaatcaatag gcaatgtttc gtcgtaccag gcgaaggggt cttcaaaaaa ttgccgaagc 1630801 cattcatcca tactatcgaa atcattcgca tcgttgcgtt ttgaatggtt catggaagca 1630861 ttcctccaca tatcaacctt gctttacatc atatgcggtg gattataaat gggtgaacgc 1630921 ataaaaaaac agacactaag gtctgctttt cttacatatc atggcttgag ttgtgctttt 1630981 gtcttgtatg gtttcggttt tttacttttt tgcttccgct tagaggctcg ggttggccgg 1631041 gattgtgtcc tttaggggcg tttttatgca tatctttact tgtattctta ttggtcataa 1631101 aatgagaacc tccttaaaag agttcggtgt tattgattgg tttttctttt tttgttattt 1631161 tggcgttctg cttcagtcag tacaagctgg tcgttttcaa tatagccggc gcctttgcct 1631221 tggctttttg cgtcattcat tccgttaatg acgtgattcg cttttctttt gaccatcatt 1631281 atcacctcaa tcataatatg gcttctttta ttgtgttata tgagagagcg taaacagtaa 1631341 aaattaccgg tacatttttc tcataagtcg aacttattgt atttaataaa aacattgata 1631401 tttacttatg tatgattttg ttttaatatg aaattgtgag aaaattgtga tggaatgtaa 1631461 tgttcatctg agaatgatct gatctgaagg gggattttgg agaatggcaa acgagcaaaa 1631521 aactgcagca aaagacgttt tccaagcgag aaaaacgttt actacaaatg ggaaaacata 1631581 tcattactac tctttaaaag cgttagaaga ttcaggtata ggaaaggttt cgaagcttcc 1631641 ttattccatc aaagttcttt tagaatcagt attgcgtcaa gttgacggct tcgttatcaa 1631701 aaaagaacac gtggaaaatt tggcaaaatg gggaactgcc gaattaaagg atatcgacgt 1631761 tccgttcaaa ccgtctcgtg ttattttaca agacttcaca ggggttccgg cagtagtaga 1631821 tctggcttca ctgcgtaaag caatggcagc tgtcggcgga gatcctgata aaatcaaccc 1631881 tgaaattcct gttgatctcg ttatcgatca ctctgtacag gtagataaag cgggtacaga 1631941 agatgcatta gcagtaaata tggacttgga attcgaaaga aatgcagagc gctacaaatt 1632001 tttaagctgg gcaaagaaag cgtttaacaa ttatcaggca gtaccgcctg caacaggtat 1632061 tgtgcaccag gtcaaccttg agttcttggc aagtgttgtc catgccattg aagaagacgg 1632121 cgagcttgta acgtatcctg atacgcttgt cggaacagac tcacacacaa caatgattaa 1632181 cggtatcggt gttctcggct ggggtgtcgg tggaattgaa gctgaagcgg gaatgcttgg 1632241 acagccttct tacttcccag ttccagaggt aatcggcgcg aaacttgtcg gcaagcttcc 1632301 aaacggaaca acagctactg acttggcgtt aaaagtaaca caagtgctgc gtgaaaaagg 1632361 cgttgtcggt aaatttgttg aattcttcgg accgggaatt gctgaactgc cgcttgcaga 1632421 tcgcgcaaca attgcgaata tggctccgga atacggtgct acatgcggat tcttcccagt 1632481 agatgaagaa gcgcttaact acctgcgcct gactggccgt gatcctgaac atattgatgt 1632541 tgttgaagca tactgcagaa gcaatggctt gttctacact ccagatgcgg aagaccctca 1632601 atttactgat gtggttgaaa ttgacctgtc tcaaattgaa gcaaacttat cgggtccaaa 1632661 gcgtcctcag gatttgatcc cgctatctgc tatgcaggaa acgtttaaaa agcaattagt 1632721 cagccctgca ggtaaccaag gattcggttt aaatgctgag gaagaaaata aagaaattaa 1632781 gtttaaactc cttaacggcg aagaaacagt tatgaaaacg ggtgcgatcg ccattgctgc 1632841 gattacaagc tgtacaaata catcaaaccc atacgtgctg atcggcgccg gactggtagc 1632901 gaaaaaagcg gttgagttag ggcttaaggt gcctaattac gtgaaaacgt cacttgcacc 1632961 gggttctaaa gttgttacag gatatcttgt gaattcaggc cttcttccat acatgaaaga 1633021 gcttggcttt aacctcgttg ggtacggctg tacaacatgt atcgggaact caggtccgct 1633081 ttcaccggaa atcgaagaag cggttgcgaa aaatgatctt ctgattacgt ctgtcctttc 1633141 cggaaaccgt aactttgaag gacgtattca cccgcttgtt aaaggcaact atcttgcttc 1633201 accgccgctt gttgtggcat atgcgctggc tggaacggta aacattaact taaaaaccga 1633261 tccaatcggt gtgggcaagg atggtcaaaa cgtatacttt aatgatattt ggccgtcaat 1633321 ggacgaaatc aatgcacttg ttaagcaaac tgttacgcca gagctattcc gcaaagagta 1633381 tgaaacagta tttgatgaca acaagcgctg gaacgaaatt gaaacaacag atgaagcttt 1633441 atataaatgg gataacgatt caacttacat ccaaaaccca ccattctttg aagagatgtc 1633501 tgttgagcca ggcaaggttg agccattaaa aggactgcgt gttgtcggta aattcggcga 1633561 ttcagtcaca actgaccata tttctcctgc gggggcaatc ggaaaagata cgcctgccgg 1633621 aaagtatttg caagaaaaag gtgtttcacc tcgtgacttt aactcctacg gctcccgccg 1633681 tggaaaccat gaagtcatga tgagaggaac atttgccaac attcgcatca aaaaccaaat 1633741 cgcaccgggt acagaaggcg gatttacgac gtactggccg actggtgaag taacatccat 1633801 ctatgatgca tgcatgaaat acaaagaaga taaaaccggt cttgtcgtat tagcaggaaa 1633861 agactatggt atgggatctt cacgtgactg ggctgcaaaa ggaacaaacc ttctcggcat 1633921 cagaacggtc attgcagaga gcttcgaaag aattcacaga agcaatcttg tattcatggg 1633981 tgtgctgccg cttcagttta aacaaggtga aaatgcggat acactcggct taacgggtaa 1634041 agaagtcatc gaggtagatg ttgatgaaac agttcgtcct cgtgaccttg tgactgtaag 1634101 agcaatcaat gaagacggca atgtaacaac ttttgaagca gtcgtccgct ttgatagtga 1634161 agttgaaatt gattactacc gccatggcgg catccttcaa atggtgcttc gtgaaaaaat 1634221 gaagcagtcc tgatgaatca ataggaagag aaggcatttc gctttctctt ctttttatga 1634281 cacaatgtgc tgcggaggtg gcatatgctg aaaaaatggc tcgcagggat cctgcttatc 1634341 atgctagtcg gttatacggg atggaattta tatcaaacat acagcaaaaa agaagtcgga 1634401 attcaagagg ggcaacaagc acctgatttt tctttgaaaa cgctatcagg agagaaaagc 1634461 tctttacagg atgcaaaagg caaaaaagtg ctgctcaatt tttgggcaac ttggtgtaag 1634521 ccgtgccgtc aggaaatgcc tgcgatggaa aagctgcaaa aagagtacgc cgacaaactt 1634581 gcggttgttg cggtaaattt cacttcagct gagaaaagtg agaaacaggt ccgagcgttt 1634641 gctgatactt atgacttaac gttccccatt ctgattgata aaaaagggat caatgctgac 1634701 tataacgtga tgtcatatcc aacgacatat atcttagatg aaaaaggtgt tatccaagac 1634761 atacatgttg gcaccatgac aaaaaaagaa atggaacaaa aactggatct tgattagatt 1634821 cagttttttt tatactcaaa tatgcttaca agttttcaga attggaaaaa ataaaagaat 1634881 atgcggaggt gagaagcgtg aagaagatga gaaaacgttc ttttcatgag ctcgtcatgg 1634941 aaaacaaaaa agagctgatg accaatacag agtatttaaa tcagcttgag gaaaagcttg 1635001 aacagcgatt taagcaaaaa taacctttaa tttgtattca tgtttacccc tccttttgag 1635061 aaacctatct gttgaggagg gataaacatg ggaaacaaca agaaaaacgg tcagcctcaa 1635121 tatgctccaa gccacttggg tacaaagcct gtaaaatata aagccaataa aggggaaaaa 1635181 atgcatgata cttcaggaca gcggccgatt atcatgcaga caaaaggcga gtagcgaaaa 1635241 ttcgagttta tttctaggag gtacatccga atgacaaaga accaaaatca atatcagcag 1635301 cctaatcctg atgatcgttc tgacaatgtg gaaaaattgc aggatatggt tcaaaataca 1635361 attgaaaata tagaagaagc agaagcatca atggagtttg cttcaggaga agataaacag 1635421 cgtatcaaag aaaaaaatgc aaggcgcgaa cagagcattg aagcgtttcg taatgaaata 1635481 caggacgaat ctgcagcgag acaaaacgga taccgttctt aaaaaaccag ggaaacctgg 1635541 tttttttctt tctgatttga ttatggtaaa atggggctaa attgacgtta agggagcaga 1635601 gtaatcttgc atgtatcaaa aaaagaaata gaagtgcgtt atgcagaaac agatcaaatg 1635661 gggattgtct atcacgcaaa ttatcttgtg tggatggagg tcggcagaac ggccttgatt 1635721 aaggacttag gctttttata tagtgatatg gaaaaaaaag gcgttctgtc cccagtcgtt 1635781 gatatcaata tttcctataa aaagccgctt cattacggag aaaccgcggt tgtacataca 1635841 tggatagagg actataacgg atttaaaacc gtctatggtt accacattta taatccggcc 1635901 ggtgagcttt ccatcaaagc cacctcatct catatttgtg tggataaaga aagctttaag 1635961 ccaattcaat tccgcaaagc ttttcctgat tggcacacag catatgaaaa ggccaaaaaa 1636021 tagggaagtg aacgggatat ggcgtttggt gtgaaacggg aggaacttaa ccggtggaaa 1636081 caagcagtga aaagaggaga aatcgcattt ttaacacatt actggctgga tgaccgattt 1636141 ccagaagcaa agaccgtgac aaaagccggc tgtgcagaca ttgataagct ggttcagtgg 1636201 ggagcggcgt acgggttaaa aaaagaatgg atccataaga aaagtgaatt tccccacttt 1636261 gatctgctgg gggaaacaca aaaatatatt ttggaacaag aaaacctaac cgatcatctt 1636321 atacgatttc atttgtaaaa aaagaacgca catgaagtgc gttctttttt attggtattc 1636381 aaaaaccggt tcatcagcgt cttctgaata gctgacgaga aggtcgtggt tatcaaagta 1636441 ccataaatca ctttcttcaa taaagaaggt aatgccatca gcttctgcag tgactccagc 1636501 ctcttgtggg gcatctttcg ctacaccgag agaaaaaccc ttttgaacgt tgctgcagcc 1636561 tccatagcgg acgaaaaagc gaacctggtc tccgctttcc aaatcgagtt cttctttata 1636621 ccagttcaat gcgtcttcgt taattgtcat attcataaca gaacacccct ttgttcttca 1636681 tttgaatttt ctctattata aacgtattag gctattctgt gtcaaaagag aagtttttta 1636741 agcttataac cattttactt taggttctgt tttattgata attcgtttaa tgttcgctcg 1636801 gtgtctgtat atcacaaaaa tagtgagcag ggtaacgaca atcaataaat acgtatcatg 1636861 gacaaagaaa ctatatataa cagtatagat ccctgttaac atcgatgaga gagaaacaaa 1636921 tttagtcaag tataaaaaga tgaagaatac cgcaaccatc gtgataaata acaggggtgc 1636981 gtaaaatagc aaaacgcctc ctgatgtcgc cacggcttta ccgcctttaa atttggcgaa 1637041 gatgggaaac acgtggccta aaaccgcaaa gactcctgca agaagcgggt gaatatcaac 1637101 atgcatgaga aaaggcaatg cagttgccag tgtccctttc aaaatatctc cggctatgac 1637161 gaccgaacca gcttttacac ccaatgtacg gaatgcattg gtagcgccta agttgccgct 1637221 tccgtgctcc cgaatatcaa ttcctttggc aagcttgccc acaattaagc cagatggaat 1637281 gctgcctatc aagtaggcca aaataatcaa taaagcaatt aacatctaca tttctccttt 1637341 ttcaaattcc cttcttttta ttttaacatg agatgtcatg atctgatgat aagttttttt 1637401 gtaaagtttg cttacaaatc aaatcaaaca tgcatcatat tttgatttct cctgttttga 1637461 tcgtgtaaaa taagtgaaaa aggagtgaca cacgatgcaa aacccttcta aagcggaaat 1637521 taaagagatt cttcaaagaa gcaaacgtat agcggtagta gggctttcag accgtccgga 1637581 tagaacgtca catatggttt caaaagcaat gcaggacgcg ggttatgaaa ttatccctgt 1637641 gaaccctaca attgatgagg cgctaggtgt caaagccgtt tcatctttaa aagagataga 1637701 cggtccgatt gacatcgtaa atgtattccg gcgctcagaa cagcttcctg gagtggcgga 1637761 agagttttta gagacagatg cgccagtatt ttgggcacag caagggctag ttaatgagga 1637821 agcataccag atgctaaaag aaaaaggcag aacggttatc atggatctgt gcataaaagt 1637881 ggcacacgct gtaacaaaat aggtgcagaa ctgcaaaaat ccttgtaaat tcaaggattt 1637941 ttgcttttta attttaagat attgtttgcg tattacggtg aaacagatac aataaagctt 1638001 gaacagcttt ttttgaatac cttgtccagc tgggtttcgg ccgttcgatt tgcgaaggtc 1638061 tgctgcttta tatataataa acaaacatac gttctcatag tgtaaaaaca gcactagccg 1638121 atgttttgag aagaactgat tcgttagctc tatgttgcga ttgcaaacat attggttata 1638181 atgaggagtc caaggcagta ctggctcgag gcgaggttta taaaaaatat cttatataca 1638241 aatgatgtgt aacactgaaa agagaaagac aatgttagtt tttgaaaggg gtttgtacgt 1638301 ttggctagaa aacagcaatt tgattacaac gaagatgcca tacaggtgct cgaaggcctt 1638361 gaggctgtca ggaaaaggcc gggtatgtat attggctcta ctgacgcgcg gggtttgcac 1638421 cacttggttt atgaaattgt agataactct gtcgacgagg tgcttgccgg ccatggagat 1638481 cacataatcg tcaaaataca taaagacaat agtatttctg tacaggatag aggccgcggc 1638541 atgccgaccg gaatgcataa gctcggcaaa ccaacccctg aagtgatttt aacggtgctt 1638601 catgccggag ggaaattcgg ccaaggcggc tataagacaa gcggcgggct ccacggagtt 1638661 ggtgcatcag tcgtgaatgc tttatctgaa tggctgacgg ttaccattga gcgggacggt 1638721 tttgtctatc agcagcgatt tgaaaatgga ggaaaaccgg ttacatctct cgaaaagatc 1638781 ggcaaaacaa aaaagacggg aactcttaca cactttaagc cagatccaac gatgttcagc 1638841 acaaccactt ataattttga aacgctctct gagcgcttaa gagagtctgc gtttttgtta 1638901 aaaggactga aaattgagct gattgatgaa cgcaatgacc agcgtgaggt cttttattat 1638961 gaaaacggca tagaagcgtt tgttgcttac ttaaatgaag aaaaagacgt cttgtctgaa 1639021 gtggtctcgt ttgagggtga gcatcattct atagaagtgg actttgcgtt ccagtttaac 1639081 gatggttatt ctgaaaatat tttgtcgttt gtcaacaatg tcagaacaaa agacggcggg 1639141 acgcatgagt caggtgcaaa aactgcgatg acgcgtgctt ttaatgaata tgcgcgaaaa 1639201 gtggctttgc tgaaagaaaa ggataagaac cttgaaggca ccgatataag ggaagggctt 1639261 tcagccatta tttctgtccg cattcctgag gagcttcttc aatttgaggg acaaacaaaa 1639321 ggaaagctcg gtaccagtga agcaagatca gcggtggatg cgattgtttc agagcagctt 1639381 gcttactttt tagaggaaaa tcgggacacc gcaacgcttc ttgtcaaaaa agcaatcaag 1639441 gcgagccagg cgcgcgaagc ggcacgcaaa gcccgtgaag aagcaagaag cggcaaaaaa 1639501 cgaaaaaaat cagaagcgac tttaagcgga aagctgacgc ctgcgggttc aagaaacccg 1639561 gcaaaaaatg aattgtatct cgttgaggga gattcagcag gcgggtcagc caagcaggga 1639621 cgagaccgca gattccaggc ggttctgcct ttacgcggta aagtcattaa tacagaaaaa 1639681 gctaagcttg ctgatatctt taaaaatgaa gagatcaata cgatcattca tgcgatcggc 1639741 gggggagtcg gggcagattt ctcaatcgat gacatcaact acgacaaaat catcattatg 1639801 accgatgccg atactgacgg cgcccatatt caagtgctgc ttcttacctt tttctatcgc 1639861 tatatgaaac cgctcattga gcatggcaag gtgttcattg cgctgccacc tttatataag 1639921 gtcagtaaag gaagcgggaa aaaggaaatc attgaatatg catggtctga tgaagagatg 1639981 ggggatgtcc tgaaaaaagt cggcaaaggc tataccattc aacgatataa gggtcttgga 1640041 gagatgaacg cagaccagct gtgggaaacg acgatgaatc cggagtcccg cacacttgtt 1640101 agggtcaaaa ttgacgatgc ggcacgtgta gagagacgtg tgacgacgtt aatgggagac 1640161 aaagtagagc cgcgcagaaa gtggattgag aaaaacgtcg ctttcggctt agatgaagaa 1640221 agcaatattt tagaaaatga aaacttatcg gtcgctgagg aggtttaatg attgtcacag 1640281 ccagaattat ttcatgattt accattagaa gaggtgatcg gcgaccgttt tggacgctac 1640341 agtaaatata ttattcaaga cagggcgctg cccgatgcga gagacggatt aaagccggta 1640401 cagcgcagaa ttctgtatgc aatgcataca gatggaaaca cgtttgataa aaacttcaga 1640461 aaagcggcca aaacggtcgg taacgtcatc ggtaactatc atccgcacgg tgacagctcg 1640521 gtttatgaag caatggtgcg gatgagccag gattggaaag ttcgtaatgt gttaatcgaa 1640581 atgcatggaa acaatggaag catcgacgga gatcccccgg cagccatgcg ttatacagag 1640641 gcacgattat ctccgatagc atctgagctt cttcgggata ttgacaaaaa cacggttgaa 1640701 tttgtgccga acttcgatga tacaagcaag gagcctgtcg tactcccggc gatgtttcct 1640761 aacctattgg tcaacggatc taccgggatt tcagcaggat acgcgaccga cattccccct 1640821 catcatctgg gagaagtcat tgatgctgtc attaagcgta ttcaaatgcc ttcttgctct 1640881 gttgacgaac tcatggaagt tattaaaggg cctgattttc cgacaggcgg tattattcag 1640941 ggcgttgacg ggataagaaa agcttacgaa accggaaaag gaaaaatcat tatccgcgga 1641001 aaggctgaaa ttgaaacaat cagaggcgga cgagaacaaa ttgtcattac tgaaattcca 1641061 tttgaagtaa ataaagcaaa ccttgtaaaa aaaatggacg agttccgtat tgataaaaag 1641121 gttgaaggca tctcagaggt tcgtgatgaa acggatcgaa cagggctgag agtggtcatt 1641181 gaactgaaaa aagaagctga tgccaaaggc attttgaatt tcttatataa aaatactgat 1641241 ttgcagatca catataactt caatatggtg gctatccata accgccgtcc gatgctgatg 1641301 agcctgccgt ctattttgga tgcatatatc ggacaccaaa aggaagttgt cacaaaccgg 1641361 tccgtttacg agcttcaaaa agcaaaagac agacatcata tcgtagaagg gctcatgaaa 1641421 gctttgtcta ttttggatga agtgattgca acaatccgtt cttctagcga taaacgtgac 1641481 gctaaaaaca atttgatcgc gaaatatgaa tttacagagc ctcaggctga agccatcgtg 1641541 tcattgcagc tatatcgttt aaccaatacc gatatcacag cgcttaagga agaggcagaa 1641601 gagctcggta aaaaaattga agagctcgaa tctattctga gcaatgataa aaaactgcta 1641661 aaagtgatta caaacagctt aaaagcactg aaaaagaaat atgcagatac gagacgctcc 1641721 gtgattgaag aaaaaattga agaaattaaa atcaatctcg aagtcatggt tgcatctgag 1641781 gatgtatatg taaccgttac gaaggatggt tacctaaaac ggacgagcca gcgctcattt 1641841 gccgcttcca acggtcagga cttcggaatg aaagatacgg acaggatgct gcatcagttt 1641901 gaaatgaata cgacagacgt gctgctgctc tttacgaaca aaggaagcta catctattgt 1641961 cctgttcacc agctgcctga tatcagatgg aaggacatgg gccagcattt ttcaaatcta 1642021 atcactattg accgtgatga aacgattgta aaggctatac cgataaaaga atttgatccg 1642081 tcggcatatc ttctattctt tacgaaaaac ggtatggtga aaaagacaga gctcactcat 1642141 tataaagcac agcgttattc taaggcactt gtagccttaa atctgaaggg tgaagatgaa 1642201 ctgattgatg tacatgtaac aaatggggaa agccagatct ttatggccac tcacttaggg 1642261 tatggtctat ggtttggaga agacgaagtg aatgtagttg gcgcgcgtgc ggcaggtgtc 1642321 aaagggatta acttaaaaga ggatgacttt gttgtctccg gtgagattct tcagcaatct 1642381 gattcaattg tcttgttcac acagcgggga gcggttaaac gcatgagtct ttctgagttc 1642441 gagaagacat cccgtgcaaa acgcggtgtc gtaatgctaa gggaactgaa aaagaatcct 1642501 caccgtgttg tagcactgtt cgcttgcggt cttgaacagc gactaatggc agaaacagaa 1642561 aaaggcgaca gaaaagaact gcagacaaaa gagttgcgga caaacgacag atacagcaat 1642621 ggctctttct tttttgatga agaggaatca ggcaaggtta cagctgtttg gcgccttcat 1642681 acagaacaat aataaaaaac ccgctcatac tatatgagcg ggtttcgttt gttttttatc 1642741 agctttcatg gttggtgaat agatctgtta cagcatgaat gacttcaatc ccctgccata 1642801 caaataaatt cagcgctgtg aaagaaaata agcctaaaat caccattctt aagataaaca 1642861 acatgtttaa cagcctcctc atattttcgt tacataatcg ggtgatgttg aacatgaagt 1642921 ttgccgaaat aagacgattg ataaaatttg gccagtataa agcttttttt ccgctgacgt 1642981 ctgcgggagt atcccgtact tttgctttca gcggtcagca gcagaacagc cattgcccat 1643041 aaagcggtca gcgtaaatgc ccctgtgatg gatttcttct catcatcagc attttggccg 1643101 gctttcatct catgcatttc ctgctggtcg gctacggctt tataatgatg gccgatatca 1643161 aaggcgtggg gaattgagaa caaatgaaaa ctggcaatcg ccaagaataa gatggatgct 1643221 ttcaatatcg ttactttttt caaatgatct ccccctcctt taatattact gaatattttt 1643281 ataataatac cccaatccat cctaaaagta aacctgattt attaaattta aaaataaatt 1643341 taactttgtt aagtatatat ctttttgctt atttttgaaa gagaaaactt cttttattag 1643401 cgtatgtata cccggtttat ggtgtgaata aaaacatatt ttaaatgata tgttgtttag 1643461 gatttattac tttatttatg tgtaaatcaa agagaaaggc aagagaatgg gaagaaatga 1643521 ttacattgtt aatagggtac tcttttttta aagccagttt gcaaggaatg tttttattcg 1643581 taggaaaata atagagaagg ggtcgacaga gtaacatctg gctatgacaa tattcttctc 1643641 gaaaaaactt cctaattcgt catattgtga tataataaaa ctcgttatgt taaaaaatct 1643701 aacatcaaaa tcgaattcgt attgaattga tgaaaacggg aggtaaatat ggagtctttt 1643761 ttcaatagtt tgattaatat tccaagtgat ttcatctgga aatacctatt ttatatttta 1643821 atagggcttg gattattttt taccatacgt tttggtttta tccaattccg ttattttatt 1643881 gaaatgttca gaatagtagg ggagaagccg gaaggaaata aaggtgtttc atctatgcag 1643941 gcattcttta tttcggccgc atcccgagtc ggcacaggga atttgactgg tgtagcctta 1644001 gcaattgcga caggcggacc aggcgctgta ttttggatgt gggtagtggc tgcagtaggc 1644061 atggcttcaa gctttgtcga aagtacatta gcacagcttt ataaggtaag agacggggag 1644121 gatttccgcg gagggccggc ctactatatt caaaagggtc ttggtgccag atggcttggc 1644181 atcgtttttg caatcttaat taccgtctca ttcggcttga tttttaacgc tgttcaaaca 1644241 aatacaattg ctggagcatt ggatggcgca ttccatgtaa ataaaatagt tgtagccata 1644301 gttctggcgg ttttaactgc gtttatcatt ttcggcggtt taaaacgtgt tgtcgctgtt 1644361 tcacagctaa ttgtgccggt tatggcaggc atttatattc ttatcgcttt atttgttgtc 1644421 atcacgaata ttacggcttt ccctggcgtt atcgctacaa ttgttaaaaa tgctttaggt 1644481 tttgaacaag tcgtcggcgg cggaataggc ggcatcatcg ttatcggtgc gcaacgcgga 1644541 cttttttcaa acgaagcagg aatggggagc gcaccaaacg cggctgcgac ggctcatgta 1644601 tcccatccgg caaagcaagg ctttattcaa acattaggcg tatttttcga tacatttatc 1644661 atatgtacgt ccacagcatt tattattttg ctgtacagtg taacgccaaa aggcgacggc 1644721 atccaagtca cacaggctgc tcttaaccat cacattggag gctgggcgcc gactttcatc 1644781 gcagtcgcaa tgttcttgtt tgcattcagt tcagttgtcg gcaactatta ttatggcgag 1644841 acaaacattg aatttattaa aacaagcaaa acatggctga acatttaccg tatcgctgtt 1644901 attgctatgg ttgtgtatgg atctttatca ggcttccaaa tcgtttggga tatggcggac 1644961 ctctttatgg gtatcatggc gctgatcaac ttaattgtga ttgcgctgct gtcaaacgtt 1645021 gcttacaaag tgtataaaga ttacgcgaaa cagcgtaagc aaggacttga tcctgtgttt 1645081 aaagcgaaaa acatcccagg gctgaaaaac gctgaaacat gggaagatga gaaacaagaa 1645141 gcataatata aatataaaac aaagctgcat tcaatagttg aatgcagctt tttcattatt 1645201 ggaaataaat ttaatttttc gactcgaatg aaaaatgacg tgtaaagtcc caattcagtc 1645261 cagttttctt tgttctatat gtgtcatgtg tgtcttattc attggaggta gagcaaattg 1645321 acaggctttt aaacctcccc aaaacaagaa attaggttga tagacaatca tgagaaagat 1645381 ttttacaatg agttcgtgct cataagaagt gtagagccaa aatgatgcga aggaggaaaa 1645441 gatcagatat gaaacggtca atctctattt ttattacgtg tttattgatt acgttattga 1645501 caatgggcgg catgatagct tcgccggcat cagcagcagg gacaaaaacg ccagtagcca 1645561 agaatggcca gcttagcata aaaggtacac agctcgttaa ccgagacggt aaagcggtac 1645621 agctgaaggg gatcagttca cacggattgc aatggtatgg agaatatgtc aataaagaca 1645681 gcttaaaatg gctgagagat gattggggta tcaccgtttt ccgtgcagcg atgtatacgg 1645741 cagatggcgg ttatattgac aacccgtccg tgaaaaataa agtaaaagaa gcggttgaag 1645801 cggcaaaaga gcttgggata tatgtcatca ttgactggca tatcttaaat gacggtaatc 1645861 caaaccaaaa taaagagaag gcaaaagaat tcttcaagga aatgtcaagc ctttacggaa 1645921 acacgccaaa cgtcatttat gaaattgcaa acgaaccaaa cggtgatgtg aactggaagc 1645981 gtgatattaa accatatgcg gaagaagtga tttcagttat ccgcaaaaat gatccagaca 1646041 acatcatcat tgtcggaacc ggtacatgga gccaggatgt gaatgatgct gccgatgacc 1646101 agctaaaaga tgcaaacgtt atgtacgcac ttcattttta tgccggcaca cacggccaat 1646161 ttttacggga taaagcaaac tatgcactca gcaaaggagc acctattttt gtgacagagt 1646221 ggggaacaag cgacgcgtct ggcaatggcg gtgtattcct tgatcaatcg agggaatggc 1646281 tgaaatatct cgacagcaag accattagct gggtgaactg gaatctttct gataagcagg 1646341 aatcatcctc agctttaaag ccgggggcat ctaaaacagg cggctggcgg ttgtcagatt 1646401 tatctgcttc aggaacattc gttagagaaa acattctcgg caccaaagat tcgacgaagg 1646461 acattcctga aacgccatca aaagataaac ccacacagga aaatggtatt tctgtacagt 1646521 acagagcagg ggatgggagt atgaacagca accaaatccg tccgcagctt caaataaaaa 1646581 ataacggcaa taccacggtt gatttaaaag atgtcactgc ccgttactgg tataaagcga 1646641 aaaacaaagg ccaaaacttt gactgtgact acgcgcagat tggatgcggc aatgtgacac 1646701 acaagtttgt gacgttgcat aaaccaaagc aaggtgcaga tacctatctg gaacttggat 1646761 ttaaaaacgg aacgttggca ccgggagcaa gcacagggaa tattcagctc cgtcttcaca 1646821 atgatgactg gagcaattat gcacaaagcg gcgattattc ctttttcaaa tcaaatacgt 1646881 ttaaaacaac gaaaaaaatc acattatatg atcaaggaaa actgatttgg ggaacagaac 1646941 caaattagtt aagctttttt ttggcggaca tcagtaacga tgtccgtttt tatcatctaa 1647001 taggaggttt gcgttgtgga tgaaatactg aaacagtata tggtgctgta taaaaaaatg 1647061 agtaatatga taaatggtcc cgactatcca ggtaaggaaa aagacatcca gcatcaaaaa 1647121 gatcagatcg aagtttacga aaaacagctg cagcaaggat tttctacaga ttatgactat 1647181 gatgtgtttg ctgattctgt tatcaaatgc gcatatggcg atatgacgct ggaagattta 1647241 gaagccgttt attatggatt gacaacacca tttttttgat ttgtcattca gcagtaaaat 1647301 ttcaatttct gtctcactaa cttaagtata ctttgatatt gagacagaaa tttatttatt 1647361 ttgtttactt cctagaatat atattatgta aactagaaaa gatgaagaat aaagctttgc 1647421 tgtttttatg tacatccttt cttcttcctg taattcagca acaaaataaa aaagcgattt 1647481 cccaatcgga aaatcgccaa ttcagacact ctattattta tgtgtgtctt tgtgctctta 1647541 acgatttaca acaaatgttg tcacgctttg agctggaaga tgagcccaaa aatgattgcc 1647601 tgatacagtg agattcgttc caggttgtag attgctgctg ctgctcgtga tccatctaga 1647661 tacgtttgaa gcagatccat tctgcaaaac aaagttttgg ttgactcctg tgttgctttt 1647721 attgatggca acaataacga ccttgttgtc acctttatag gctgacacgt aaacgttcgc 1647781 attagggttt ttcgttgcat caatccttac atagccggga cgcacaaact ttgagaaatg 1647841 agccatattg tagccgcgtt tgctgatcgt accatcttct ttcataggtc catatgatct 1647901 tcggatgtac caccatacat aagcttgaaa gtccccctct accatcgcat tgtgaatatg 1647961 ctgtgaaaca tccaatgcct caggccatcg atccgccgag ttggtatcac tgtttggata 1648021 gtatacttcc gtcatccaaa ggtccttccc cgctcctttt tgtttgaaaa gaggataagg 1648081 gaattggctg acctgggtgc cgtacaggtg agttccgaga atatccatat tggcaagagc 1648141 ctgcggatcg ttcaagatcg ggtccgacaa attcttcaag tattgaaatg actcaggcgc 1648201 aatgacgcgg gcattgatcg agccggcgtt ttctctcata aagcgaagta tttcttgcgg 1648261 cgtccaccac gtccactcgt gagcgtaatc aggctcgttt tggaccgaaa tcgcgtaaag 1648321 attcacacca ttattcttca tgaaggtaac aaaatcgtta agatgctgcg cgtatgctgc 1648381 gtacttgttg tatttcagcc gtttagccga tgtgtcacca ttccgattaa aggtctcaac 1648441 catatcactt ggaggattcc aaggagaagc aaaaacgatt gctccgtgtt tgaccgcact 1648501 ctttgcagtc tccacctctt tataccaatt atttcgattt tcatctacat gaattcttaa 1648561 gattgaaaat cctaactggt tctgtccatt gccaaaagca gtttctcttt gagctgctgt 1648621 aagatcccca gcccaagccg gatgattcat ccctccaaaa ccgcgaatca cttgtttctc 1648681 tgcagataca ttaactgtta catcacttgc tgccaaaact tcagtagcgc ctggccctaa 1648741 catgactgac agcatagtga aacatactaa tagtacacaa attgtttttt ttatgcgtgg 1648801 aatcatttat tcctctcctt cgtcatgtgt cttttacggt attaaaaaat ctgcatggca 1648861 tatccataat ggcgggctgt tccggtgctg gcccgtactt cacccgcctc gtttttaagc 1648921 ggtcccatta cgagtactat ctttgcgtaa actgccagta atcaaaatta aacaagtttc 1648981 ctgtacctgt tccggtaaat acaaagaata ctttgtgcac accggttgcc ccgcttaccg 1649041 cagtttctat ttccctccac gtttgcgctc cgcctgttga aggcacattc agagttccaa 1649101 caagcttacc gtctgcactg tcgaggcgca cttctatttt cccgcctaaa gtggatgcta 1649161 catttgcttt aaatgacctg gcaccgcccg ctccgaagtc tgcatttcct acagcaatcc 1649221 agtctccatt ttgaatgctt gttacatgct gattatttac tggcccgccg ggtgctgtgg 1649281 acttctctgt caaaatgcgt ccattccaag caaacgtttc agcttctacc cggttatatg 1649341 ggtttaaatt ggaaatttgt gttacacctg cataatttgc cgctacctct tgaatagatc 1649401 catctgcatt atgcaccagc ttattaatat ggggagagcg gtatcctttg ccggccccga 1649461 acagagcgga actgacagtt tgcgcatggt acaccacata ccactcgttt ttaaaattga 1649521 aaacagcatg atggttgttt ccgccacctc cgaaaaatgc acccggattt ttcaggaagt 1649581 gccctctata tgtaaaggga cccatgggac ttgaactggt catgtagccg atctcacccg 1649641 ggggtttatc ggccgggtgc gtgccgccga aattgatgca ataggagtaa taatatgttc 1649701 cgttatactt gtgcaatccc gaatcttcaa acatgaaagg cgcatcaatt gtagatgcac 1649761 ttccaacaac actcgtcata tcaggcccca attttatgac tctagccgtt ttaggattgg 1649821 cccattgtcc ctgcgttgga tttgaaacgc caggaacgcc tccgccggca tacaggtaac 1649881 cggttccgtc gtcatctaca aatactgccg gatcaaaaag ccatacaaca ccagacattc 1649941 ctggcgtact tggcgttacg agcggttttc cgattgggtc ggtccatgga ccaatcgggc 1650001 tgtctgcggt gagaaccccg atacctccgc cgctgtttgc gaaataaagg aagaatttat 1650061 ccttgccatt aattttttta actgcgattg acggtgccca tgacgcacct gcccattttg 1650121 caattccacg gcctccatta gctccattgg cacctgctac cggaatggct ccgtggtctg 1650181 tccagttcac catatccgct gaagatatga cgaatactct attcaaattg gcaaatgaat 1650241 tatctttaat tgttccgttg ctattatatt catagtcatc acttgacata tagatgtaga 1650301 ctcttccgtt ataggtcagc gcaaccggat ccgctcccaa atgatggtcg ataagcggat 1650361 ttgaattccc tatatgtttt gcaattgtag tactagtggc agcatacgca gacttcccag 1650421 ataagcagct caataataaa actagaatcc ataaacatac gctacacttt ttcctcatca 1650481 cttcacatcc tcctttttcc ttaaaatggg ggattttctt ttggaatttg ataacaacag 1650541 gtcacgaaga ttgcacgcat aaagtagccg gaagctgttt agcaatgttc ccagttgttc 1650601 tgaaagctca tcttcatgtg tctccattct ctcttttctt cgaggagatc gcaccactcc 1650661 ttcaaaattg ttcaaaaaaa cttccccatt cctagcgacc attgtccaga aaataaaaag 1650721 acaggattgt tcatggcctc ccactaatca cattgaacgg agattacatc attatccaag 1650781 atatcccttt atctaacatc ctacatcatt aaaaaaattg tgtatagaaa cttttggagg 1650841 agttagtgtt cgattctaca aaggaactgg atacatttat tcattgataa gatggggcta 1650901 acactccgtt tatatttgta tgttttcaga cacaaaaaac agccgttcaa tgcggctgtt 1650961 tttttcaaga gtataagact attgagcggt atacccgctt tttcatgttt tgttcatatt 1651021 ttattaattg tttattcaac actgtccgct atagtaatcc atatcaacaa atatgactgc 1651081 cactcgcatc ttttatgaag ggaggttcgt tacgctgaaa gaaaaaataa agacattagg 1651141 ccgtttttgc accgtaggcg tcggcaatac gctgatagat tttggtgtct tctttcttct 1651201 taccgcttgt catgtctctt atctgccggc gcagatctgc tcctatactg caggtatcgt 1651261 caacagctat gtgtggaacc ggaattggac gttttgtgtg aaacgtaagg ctgacgggaa 1651321 agagatcgtg cgttttctca tgattaatat tgccgcgtca gggatcacct ttttgctgct 1651381 ttatttgttt caaaattgcg gctgctcgct tttggtgagt aagctcgccg ccactatcgg 1651441 cggaatgatg atgaatttta tcggaaaccg aatctgggta tttggagatt cgctgaaaaa 1651501 catacaggat caggagtgaa gatgaatgag aaaaaaagtg agaaaagcgg ttatacccgc 1651561 agcgggttta ggaacgagat ttctgccggc gacaaaggcg cagcctaaag aaatgcttcc 1651621 aatcgtcgac aaaccagcaa tccaatatat tgtagaagag gccgcagagt caggaattga 1651681 agatatactg attattacag ggagaaacaa acgctcgatt gaagatcatt ttgatcggtc 1651741 ggcggaattg gaattcaatc tccgggaaaa aggcaagacg gagacactta aggaaatgca 1651801 gcagattgcc gatttggcca acattcatta catccgccag aaagaaccgc tcggattagg 1651861 ccatgcggtg ctgtgtgcgg agcattttat cggagatgag ccttttgctg ttctcttagg 1651921 tgatgatatt atggtgtctg aaacaccggc tcttcggcaa ttaatggatg tatatgacgt 1651981 ttatggcaca gaggttgtcg gtgtacagtc agttctccct gaggatgtca gcaaatatgg 1652041 tattataaat acatcagggt ctcaagggca tgtatatgaa gtgaacgatt tagtggaaaa 1652101 gccttctcct gaagaagcac cttcggaaat cgcagtaatg ggacgttatg tgctgaattc 1652161 ttcgatcttc tccgttttga agacaattgg cagaggcgcg ggcaacgaaa ttcagctgac 1652221 agatgcgctt cgtgaggttt gccgtaagga gccgatccat gcccggctgc tggaaggaaa 1652281 tcgatatgac attggcgata agctgggctg ttttaaagcg agcaccgaaa tcggcttaat 1652341 gcgtcccgaa atgagatctc agcttttggc ctatttagaa gatgtgatca aacgggaaac 1652401 gaaagaaatg ctgcggtaaa aaaattgtaa ccatcttgct cgtcaatcag tcatataata 1652461 gtgaaaaaga ttaggacagg ttgtgaagaa tgtgggcagt ttgataagcg aaattttaac 1652521 atggctgacg aacatgggat atgcgggtat tgcgattggg ttaatgattg aaatcattcc 1652581 gagtgagatt gtattagctt atggcggcta tatggtatcg gagggcacga ttggatttat 1652641 tggcgcaatt attgcgggtg ttatcggggg caccattgcc cagatcttta tttactggat 1652701 cggtcgctat ggcggcaggc catttctgga caaatacggg aagtatttat tgattaaaaa 1652761 gcatcatatc gatatgtcgg aaaactggtt tcagaaatac ggcgccggag ttgtcttctc 1652821 ggctcgtttt ataccggttg tcagacatgc catatccatt ccggcaggta ttgccagaat 1652881 gccttttctc aaatttgtgg tactgactgt gcttgctatc attccatggt ctatcctgtt 1652941 tgtttattta ggcatacagc taggaagcca gtgggatgat gttgagaata tagcaggcac 1653001 ttatacaaca ccgattatga tattggctgt tgtcgtgata gccctttatt ttgtgattaa 1653061 gaaacgtaca gccatattta aacgatagct agcggatatg cataggggtg actgacgctc 1653121 ccctatgcat atttttttac ttgcgatgtt gatttgccag cttcagattc tccgctaaaa 1653181 atgcgacaaa cacttcatcc cgcacgagcg atgcggcata atttctctta ataaaccatt 1653241 ctgcctcttc aaacgctgcg aatgtttcgt cttgggtttc tccgttaatt tgaatattcc 1653301 attcgttgtc taaagggaaa agaaaaaatc tcatttgtgc gcgattttca tataatgatc 1653361 cattcgcaga tccctttaga ttatagatgt tacggaaggc atccggccgt acaggatcaa 1653421 tacggaaagc ttcagctaca aacaactcgt atacttcatc ggttattgaa cagccggacg 1653481 cttttgcatg ccctccgccg ccatatcggc cggcgatttc tgacacatcg atgtaatcat 1653541 gaatggtgcg gagactgact cgttttgacc ccatgctcaa aatcgcaatg taatcgaggt 1653601 gcgggttatc tttccctagc ctgttcccca gctctgaatg gtacgattca gcgtgaacga 1653661 tgcctacaca gtgttcgtga acaaaggttt gtaccatttc ccttttcttt ctgcggaggt 1653721 agcgctcgat tttttcgtct tctaaatcaa gcagtttttc ttcaaaatca tcgaagaaaa 1653781 attcgtcatg cgtggaaagg cgctggatca tttttgcttc aaattcatcg attgacagca 1653841 aaaagaaaag atcattaagc cgcttcgcct gtttttgatc gtaccgctcc cactcccatg 1653901 tatcgtattg gcggacgagc tctgtgaatt gatctaaggc gtttgtcggt ttcatgaagc 1653961 cattttcaat gagatagcca tataaaagcg atgtcgcgga tgtgagcctt ccatcatcgt 1654021 attccacctg gacaaatccc cattcatgct cattcaaatg aagggctgtt ttatgatggt 1654081 caatgagctt cactttgccc cctgcatgaa catactcatt caatctctct tcgttttctt 1654141 cattgacggc gagatcggtg atgaataacg cgtcctgtct gttgctctcc ttcgcttttt 1654201 ctaaaaagta ctgcacctgt gcgtttaagc cgttgacaga gttataccgg atctctacgt 1654261 cttttccgaa cgccaatttt gctacgattc cgcatcctac tccgtccaag tcgttatgtg 1654321 aatataaatg atacataatg taggcccctt tttatgataa actgacaatt gccgctagag 1654381 gtgcggcagc ctttatttac tattctaaaa aaccaagcgt tttatgcaat ggtaattagt 1654441 tgacataatg ttgttattgt aaatatataa aggagcgctt tttttgcgct cctaagttct 1654501 tgcttttaca ccggataaac cggatgcttt cgattggtaa atgtcatttc ctttgtcatg 1654561 tatgccttga gccgtttggc cagctcatca cgcagcgaat tggctgggat aacagcatca 1654621 atgatcattt ctgaagccag acggtagata ttgatgtcct ctttgtattc ctcccgtttg 1654681 ctgctgataa atgcggctct ctcttcttct ggcagctcgg cgattttttt agcgtagaca 1654741 gcgtttacag cggcctcagg gcccatgacg gcgatttggg cggttgggag cgctagacag 1654801 caatccggtt caaatgccgg ccctgccatt gcatacaacc ccgccccgta agcttttcgg 1654861 acaatgacag agagttttgg aacagttgcc tccgacatcg cagaaatcat tttcgctccg 1654921 tgtctgataa tcccagcctg ttctactttt gtgccaatca taaaaccggg gatatcggct 1654981 aagaacagca atgggatatg aaaagcgtca cataaggtaa taaacttagc cgctttgtct 1655041 gctgaatcgt ggaataagac gcctcctttt accttcggct ggtttgcaac aatgccgaca 1655101 ggctgtccgt ggattcgtgc gaggcccgtc aataattccg gtgcaaataa ggctttgatc 1655161 tcaaaaaatg agtcttcatc tatgacccgc tcaatgagct catgcatatc aaaaggtgcg 1655221 ttttgatttt gcggaatgac gtcggcaagc ggagtttcga agtgttttgg cgggcgtttc 1655281 tcatgaatgg gcgctttttc ttgaaaattt gccggaaagt aagacaaata agcccgcacc 1655341 agctgtatgg cttcttcttc agtttctgca agaatatctc cgcagccgga gattgagcaa 1655401 tgcatacggg cgccacccat ttcttcgaga gacacttttt ctccaataac catttccgcc 1655461 atccttggcg aacctaaata catggaggcg ttaccgtcta ccataacgac gatatcacag 1655521 aaggccggaa tataagcgcc tcctgccgca gatggtccga aaagcagaca gatttgcgga 1655581 atgcgtcccg ataatttgac ttgattgtaa aaaattcttc ctgcaccgcg tctccctgga 1655641 aagacattga tttggtcggt aattcgggcg cctgccgaat cgactaaata aatgagcgga 1655701 cagtttaatt tttcggcgat ttcttgaatt ctgatgattt tttcaactgt ttttgctccc 1655761 catgaccccg ctttcactgt tgaatcattc gccatgacgc aaacggtttg gccgccgatt 1655821 ttgccgatag cggttacaac tccgtcagcg ggaagcccgt ctgacataca ttccgcaaaa 1655881 aaagcgtctt ctagctcaat gtcatcgtca aagagaaggg aaagccgctc tctgacaaag 1655941 agcttgcctt tttcccgatt gctttgatga tacttttccg ctccgccttt tcgaatccgt 1656001 tcagcccgtt ctgttcgttc cttttcataa tccatcagca ttgcctccct tttatattcc 1656061 cttgtatacg gcccgtcttt tttcttgaaa ggcctgaagc ccttctctcc tgtcttttgt 1656121 cgggatggtt tgttcatacg ctttttgttc aatcgcaagg cctgtagcaa gatctgtctc 1656181 caatccttta ttgattgcaa atttagcctg acggacagcg atcggtccgt tggcagaaat 1656241 ggctgcggcc agttcctctg cttttggcat aaggtcacaa ggagccgtga catgctctac 1656301 aaggccgatt tcttttgctt cgtgtgcggt cacgcgtctg cctgtataaa tgaattcttt 1656361 tgcttttcct ctgccaatca gccggggcag cctttgggtc cctccagcgc ccgggataat 1656421 agctaaccct gtttccggaa gtcccagcac agctgcttca gttgcgattc gaaggtcgca 1656481 tgccaatgcc aattctagtc cgccgcctaa tgcgcttcca tttatcgcag ctatgaccgg 1656541 ctgcggcaag gcatcaagta aagccgccgt tctttgaatg agagatacac tttccagaac 1656601 ctgatcttct ttcagtttta tccgttcctt caggtctgcc cctgcacaaa acgctttttc 1656661 accggtgcct gtgaggatga cgcaacggat gtttgagtta aattcaattt cctggataat 1656721 catttgcagg tttctaagca tttccgctga aagagcattt gctgcctgag gcctgtttaa 1656781 ggtgatcaac gccatatgtt catttttaac agtaaaaaga atagaatctc ccattgtatg 1656841 cgtcctccct tttatcaaga tgatttaaac acctgtaaat ttctgctcgg cagcggtttg 1656901 cccatttttt cttcaatcca tttggccgca gatagcagtt tttctagctt tacatttgtt 1656961 ttgatatcca tctgttcaag catgtacacg atatcctcag ttgcggcgtt tcctgatgaa 1657021 cctggcgcat atgggcatcc cccaagcccg cctgccgagc cgtcgaacac cgtgatgccc 1657081 atttggagtg ctgtgaccat gttggccaga gcggttcctc tcgtatcatg aaaatgcagg 1657141 gcaatttgat tagccgggaa tcgtgccaaa agagcttcaa gtacagtttc cacttgggcg 1657201 ggattagctg ctccaatcgt atctccaagc gacagttcag aaatcccaaa ttcaaataga 1657261 gcttctgaaa ggcgaatgac ttgttcaatg gggacatctt tttcgtacgg acagccgaaa 1657321 acagtcgaga ggtaggctct tgttgtgagg tttgcttttt gtgcgtcgtt gtttacttgt 1657381 ttgagtatat ggagggattc agaagtggat ttattgatgt tttttctgtt gtgcgtctcg 1657441 ctggcggaca taaaaacgca agcctcgtta atgcctcctt caagtgcatt ctccagtcct 1657501 ctttgattcg ggacaagtgc cgcgtacgtt accccttttt ctcggtcgat gccttttgct 1657561 acatcgatag catctcgaag cgccggaatc catttcgggt gaacgaagga tgtgatttca 1657621 atatacgaca gccctgtccg ggaaagctgg ttgatccagg ttattttatc ctctgttgcg 1657681 atccaaacgg gctcgttttg taagccatca cgcgggccga cttctttgat tgtcactttt 1657741 ttaggatatg gcatggtctt cctccaaatt attgagtgga attgctcagt tcgagcagta 1657801 cgtctccttc atttacaaag tcgccttcct tttttttgac ttcttttacg attccgcttc 1657861 tatctgcaac gatcgggatt tccattttca tcgattccaa aatggctacc tcctggccct 1657921 tttcgatttg gtcgccggct ttgacgtgga ctttccacag gtttcctgcc atttgtatgc 1657981 taaccgtcat gacaactgcc tcctttatag gtgctgtttc aaaaagtcag tcgtgacatc 1658041 cccttcttta aatgcctttg ttgccgcagc ctgtatgagg agcggaaggt ttgttttgat 1658101 tccctctaca cgatagtcgc gaagcgctgt ctctagtttt tcaattgctt ctgttctggt 1658161 ttggcctttg acaatcatct tagcgatcat cgggtcataa aaaggggtaa cggtgctgtc 1658221 ttttgctacc gcacattcgt gtctgactcc tttttggtca ggaagtgaaa acgcagtgat 1658281 cgtacctggt gacgggaaga aggtcttggg atcttccgcg tatattcgaa cctctatcgc 1658341 atgcccgttc cgttggatgt ctttttggga gaatgtgagt gtatggcccg cagcaatccg 1658401 cagctgctgc tcaactaagt ccaggcctgt tatttcttca gtcacggggt gttcaacttg 1658461 cagtctcgta ttcatttcga ggaaataaaa attttgtttc tggtcaacta taaattcgat 1658521 ggtgcctgcg ttcgtatagc cgattgcctt cgctgctttt accgctgttt gaccgatctt 1658581 cattcttagt tcatcgtcta caaatggaga cggtgcttct tcaatgactt tttggtggcg 1658641 cctctgaaca gagcaatcac gttcaaacag atgtactgta tggccgtgtt gatcggccaa 1658701 aagctgaacc tcgatgtggc gcgcatgttc aataactttt tctatataca tagacccgtc 1658761 accgaaaaaa tctgctgcgc gctttttgtt tccctcgtac gcttttttta atgcttcttc 1658821 attttcaaca cgctgcattc cgatgccgcc tccgcccgct gaagctttca gcatgacagg 1658881 atagccgatt tgacttgcgg tgcggcaggc tgcctctata tctccgaggg attcagaaac 1658941 gcccggcacc acagggacac ctgcagcctc cattgctttt cgcgcttcaa ttttgctgcc 1659001 catctttgcg atgatatcag gggaaggtcc gataaacacg atgttttctt gcttgcagcg 1659061 ttcagcgaac cggctgtttt ctgataacaa tccatatccc gggtggatcg cgtcggcttt 1659121 tgcttttttc gccgtcttta tgattctctc tatatttaaa taactttcac tgactctcga 1659181 ttccccgatc aaatatgcct ctgtagcggc ttttgtatgg ggcgcgtcct tgtctgcttc 1659241 tgaataaaca gcgaccgttt taatgccgag acggctgcat gttcggataa ttctcattgc 1659301 aatttcaccg cggttggcga tcagtacttt tgtaaacatg atttcacctc attgacttga 1659361 tgataagttg aacatttcaa tcgttttttc tcgcagttta tatttttgaa ttttgcctga 1659421 ggccgtcatc ggatagtcat ccgtaaaaat aacataacgc ggaattttgt ggcgggcgat 1659481 tttccctttg caataggctt taagctcatc aggtgaaacg cttttaccgt ctttcagttt 1659541 aatccaggct gcagcttcct ccccgaattt ggcgtcaggc acaccaacca cctgtacatc 1659601 taaaacagcg ggatgctggt ataaaaattc ttcaatttcc cgcggataaa tgttctcgcc 1659661 gcctctgatg agcatatctt ttaatcttcc ggtgatgcgg cagtacccgt cttcatccat 1659721 gacagcaaga tctccggtaa acagccatcc gtcatgattg attgcttttc tggtcgcatc 1659781 tttgtcttta taatagcctt tcatgacgtg atagccacgg gtgcacagtt ctccctgcat 1659841 gcctctttga acttcttgac atgtcccggg ttctacaatt ttcacctcag tatgtggcag 1659901 ggcacggccg gttgtttcga ctcttcttat gaaggaatca tttgctctcg tttgtgtaat 1659961 gactggcgag gcttcggttt gtccataggc gatcgtaatg tctttcatgc ccatcctttc 1660021 aatcacagct ttcatcactt cacttggaca gggagagccg gccatgattc ctgttcggag 1660081 cgtcgataga tcatatgcat caaaatccgg atgatgcagc tcggcgataa acatggtagg 1660141 cacaccatgg agcactgtgc atttctcttt ttctaccgtt ttaaggacgg taacgggatc 1660201 aaattcttgc acgggtatca tggctgcccc gacggataca catgccaaaa ccccaaggac 1660261 gcatccaaag cagtgaaaaa acggaacagg gatgcacatg cggtcttgag aggttaaagc 1660321 catacattca gcgatattag cagcgttatt gatgacattg aaatgggtca gcatcacgcc 1660381 ttttggaaac cctgtcgttc ctgatgtgta ttgcatatta atcacattgt ctttatccag 1660441 gctgttcatt ctctcttcaa gctcagcatc tgtcactgtt ttcgccaata tctctgtatc 1660501 gtcccaatga tacatgccag acaatcgttt attgccaata tagatcagcg tttttaaaaa 1660561 gggatagcgt tcagatttca gttggccggg ctttgcttct tgcagttctg gaattaaact 1660621 gttcacgatg tctggataag aagtgcccct gtatgaatcc atgataataa gcgccgcggc 1660681 atccgattgc tttaacaagt aatcaagctc atgtgcttga taattggtat tgacggtcac 1660741 gagcacggct ccgatcttcg cagttgcgaa ctggacggca agccattcag agatattaga 1660801 agcccatatg gcgacgtggt ctccttttcc aatccccatc cgcatgagac ctttagcggt 1660861 ttgacggcac agactgtcaa attgagcgta cgtatagcgg atatttcggt ctggatacac 1660921 aacagcatct cgatcgggat acgcatcagc tgtttgttcc agcagcctgc cgattgtgga 1660981 atggatgagt tcagccattc attgttcctc ctttcttaat gataggaaag cgtttacatt 1661041 tttattttaa aagctgtctg gcgatcacga gacgctgaat ttcagatgtg ccttcaccga 1661101 tttccattaa ttttgcgtcc cgcagcatcc gttccacccc atactctttc atatagcctg 1661161 aacctccatg gatttgaatg gcttgattgc aagctcttgt cgccatttca gatgcgaata 1661221 gcttggcgta cgccgcttct ttggtgaacg ggcggttatg atctttcagc caggcggctt 1661281 ttaacaccat ttgccgtgcc agatcaattt ccatcgccat gtcagcaagc ttaaattgaa 1661341 tcgcttgaaa ggaagaaatc ggctgtccaa actgctttcg ctctttcgca tatgccaatg 1661401 atgcgtcaag ggccgcttgg gcaatgccga ctgcaagagc agcgatggag attcgaccac 1661461 catccagcgt atatagaaac tgtttaaacc cttttgttgg atcgccaagt aagttggccg 1661521 caggcactct tacatcttca agcaagattt ccgctgtatt cgaaccgcgg acgcccattt 1661581 tatcgtacgg gctcgtaatc gtaagtcctg gtgtgtcagt tggcacgatt aatgcggaga 1661641 tgatgttttt tccgtctttg tttttgcctg ttacggcggt tacaataact gtgcgtgcgt 1661701 agcttgcatt agtgatccag cacttttcgc cgttgattac atactcgtca ccatttgaaa 1661761 tcgcttttgt ttgagtgcct cctgcatctg agccggcatt tggctccgtc aggccgaatg 1661821 atccgagtgc tgtgcctgaa gccagcggcg tcaaatgcgt ctgtttttgc tcttctgttc 1661881 cgaagtagta aagagggctt gcgcctagcg agaccgctgc agcatagctt aatccagtac 1661941 tgccgcaggc tttgccgact tcttcaaccg ctaaggcata tgaaatcgta tcaccgccag 1662001 atccgccgta ttcttctgga aatggaatac ccatcagacc gagttcaccc atttttttaa 1662061 atgtttgcat cgggaactcg cctgtttgat ctacatgttc agcgtgagga gcaatttctt 1662121 ttttcgcaaa atcttttacc atttcacgca ccatttgttg ttcttttgtc agctcaaaat 1662181 tcacatcgtt tcctccttca catctttgta acatcctatt aggcgagttc tataatcatt 1662241 ccctgacaag aaaagtctga aaattaaaac tgaatcattt tttatgtgat aatatcagcg 1662301 ggatgagcaa atacatgcag taggcgcata ccatccatat cgtaaacgca ataacttggc 1662361 cctttgataa agccgggaag atgaggggaa gattccaaag ggaaatcgta tccatcaata 1662421 aaccgaccgc tgatccccat atacctagct tgatcaccgc gaactgtgat tgatcgagtt 1662481 tttgatagag aaagaacaca aggcataaaa caagagcagt gcccgctccc aagagaagaa 1662541 agttcggcaa aaaggcttct tcagccggat cagtcaacac agcatctccg aacagcacaa 1662601 aaaataatgt ggcacctaac cagactagaa atgaaaacgt aaaacacgtc ctgtacgtgt 1662661 ttctcttcga ttttattttt atttagtact agtttctcag attccaataa tggtaaatgt 1662721 ccaaacaccg cctccatatt catgtgaatc tcacctttgt tttttaaaaa attcagcggt 1662781 ttaccatcgt ttcctgtccc aaaatcactt tttaaaaaaa gacgacttag aaagccgtcc 1662841 ttctcatttc ttattttgtt gttcgtttgg aagctttgct ttcgttatga agccggtctg 1662901 ctgaagtgac ataatacgta tatttcttgt tgggatctgc cgtgttatct aagaaggttt 1662961 gctgctcatg tgtttttctt tgcgttgcca gcaatgttct ctgctttttc ccttcggctc 1663021 tgtatatcgc ataataggct gtttctttcg ttttttgatt tgatgggtga tctttaatct 1663081 gcagaagatt gccgtttttg tcttcggtga ctttcgtaag cttcggtttt tttggggcgg 1663141 tattgtcaag ccaaggcatt tgcggaacca gtgccggctt gctgtaaaga tcggtgctga 1663201 gactgtcttt gatgccaagc ggatttttgt tgaggtcctt gaggctgaaa tgcatgcttc 1663261 ctttcaccag ttcaagctgg cggttcaaag tgatttgccg cacatattcc tcaggatcgg 1663321 accaaggcgg atcaaaattg ttattgattt tatatgctgc ctggccaata tataagtgaa 1663381 caggcctatt tttgacttca ttgctccacc aatcagccag cacgtcgtaa gccgctgcgt 1663441 taaagccgat actccaataa atttgcggag caatataatc gatgtcgcct tcttggatcc 1663501 aatgccttgt gtctgcatat agatcgtcat aatttctgac gcctgctttt gtattcgatc 1663561 cggtcgggtc atctgcggcg tttctccata ctccaaaggg actgatgccg aatttgacat 1663621 acggttttgc agctttaatt gtttggttga tttgtttgac aagctggttc acattgtccc 1663681 gccgccagtc atcgatatta gaaaaagcgt cttttccgta ttgttcgtac tgtgcttgat 1663741 caggaaattc ctgtcccgct attttataag ggtaaaaata atcatccata tgaacagcat 1663801 cgatatcata atgttttacg acttcttcaa tgcctttgac gataaaatct ctcgcttctg 1663861 gaatgcctgg atgataatac agctggtttc cataggcggc aacccaatct ggatgttttc 1663921 ttgccgggtg atcctcagac aatttattaa gatctgtatg attcattgta atacggtaag 1663981 gattaaacca cgcgtgaaat tccaaatttc gtttatgggt ttcttcaatc ataaatgcaa 1664041 gaggatcata gccggggtcc ttcccttgga caccggttaa gtattccgac caaggcccgt 1664101 aagctgacgg ataaaaggca tcagccgtcg gtttaatctg aacgataacg gcattcattc 1664161 ccattttttg cacatcgtcc agcagtttga tatactcctg tttttgctct ttcacagata 1664221 accctttttt ggacggccaa tcaatattta atacggaagc aatccatacg gctctcagct 1664281 ccctgtcaga ctgcgcattg gccataaacg gaacggaaat gacaaacgtt ccgatgatca 1664341 agctgacaag gaaacggaca atcgactttt ggcaaacctt cattctgttt cttctccccc 1664401 attacatcac tttcactatt cgctattacg gtattcccgg gctataaaag ggtgattaac 1664461 agaatgtcta tctcactaaa taaacgaaaa aagtcctaaa gcatgttgtg aaccgctttt 1664521 aggacttttt atcattcatc atggtttgca gactttttaa cacatcaata agttttacgc 1664581 cgacaccgac agccgtttca aggatcgctt gtgctccggc aatggctaaa ataaagatca 1664641 gcggtattgc aatacgaggc aaaaaaagat agccaagtcc gatcaagatg gcacaccaaa 1664701 caccggcaca ccagtagcaa ttgagcatgt atccaaagtt agaagccggc acgctttttt 1664761 catctacatg cccgttttga tcaacaatcc ttttcttttt cataaaaggt tttcggataa 1664821 attctgtgat tttgtcaaat acaatcaaat gtgtcagcct gtaactggct agaatcagca 1664881 tgataaaagt tagaaaagaa agacggtcca ttgagaagcc tccaagaaaa aggatgatgt 1664941 tatcattccc aagtgtccct tatccattct tgatacaaaa agaaagacgg acagagaatg 1665001 gcctctgtcc gctaatccga gctcattccc tccagttctc ataataagag gataagaaaa 1665061 tgtagaaaaa agcagaaaaa tgacaataaa agaaattata tgactatata atccatatat 1665121 gcactatatt aacggatatt ttttaaagta caataaaaaa cattaaattt ttataacatt 1665181 ttttttgaat atagtattat ttctttattt ttcgtttctt tttttatcaa atttccggat 1665241 ataaagtgat aaaagtattg ttttacataa ggtcttatac actacttttt aatcggacta 1665301 attttctttt gtgcatcatt cttctaattg ttggaaggtt cgacaaagcg ttattacaga 1665361 cataaaaaaa cctgttttct cttggaaaac aggtctcccg ctattattga tttgccaaaa 1665421 tgacagcgat ttgatcctca atatcttttc catcctcttc atcaatcaat ccatttagaa 1665481 gaatagagaa aacaagtttt tttccgctct ttgtttctgc gtaccccgat agagagctta 1665541 ccgtactgag cgatccggtt tttgctctta cttttccttg tgcaggagtg cctttcatgc 1665601 ggtttctcag cgttccgccc accattctgt caggattccc cgcaacaggt aaagaattta 1665661 gataagccga gaaccaactc tgatcctgaa tgtcatataa cagctgtgaa agttgatctg 1665721 aggatacagc atcaatatgt gagattcctg atccgtccct taagacgagt gatttagaat 1665781 caacaccaaa ttccggaagc gtactgttta acacttcgag ccccttttcc cagctccctt 1665841 ctcctttttt cactttcccc atctctttta cgagcacttc ggcatgtccg ttattactta 1665901 atttcatgaa cggcacaaaa agtttcgata aaggcattga gcgatgagag agcagcacat 1665961 ctgaagaact aggtgcttca cccgtcttga tgtccccttt cacagtaata ccttgttttt 1666021 ttagtgactg cttaaataaa tctaaggcat atccggcagg ctcccagaca gaaatccatt 1666081 cctttgtctt gtttgcgtca accggtacgc tcccttcaat tgtaatcgtg tttgttccat 1666141 gctctctttc gattgtgagg tctttctctg aaccggcagc agtcgtttta gcatcgttct 1666201 ttatcgttat ataatcggtt ttcggagaga cagacacggc aggctcttcc ccttcttttt 1666261 gatttggggt gacctcaaca atcacagtgc ctgcatcata gtcttcgttt ggagacgctg 1666321 ttagagcgga gattggcgcg ccataatatg tgtattcatc gctccaaggc atatcaggtg 1666381 ataatcgcat gtcatcatgc cacgtatcat caccgatcag attgccttta attactttta 1666441 cgccggaatg tttcaatatc tcagccattt tgtcaaaatc agatggtaaa agtgtcggat 1666501 cgcctttccc tttcaaataa aggttaccat tcagcttttt ccctttcagt gttccatccg 1666561 tccggacctc ggttgtaaaa gaatagttct cgccaaggac agaaagtgcc gcggccgctg 1666621 tcaaaagctt tagagaagag gcaggcctca ttcgggtgtc tcctgaatgt tcatatagaa 1666681 cagcacctgt ttccgcagag cgaacggtga tgccggccat tgcgccttcg agggcaggat 1666741 gatcagctaa aatcttatcg atctgcccgg aaagtgcatc ttgtttttca gcggcaagcg 1666801 cagcctgatg catataaggc accgaagcaa cgacgaaaag cagtaaaaca gcaacataaa 1666861 gctttatgct ttttttcatt aatttccccg cctctctgcg cttcatcatt ggctattgat 1666921 gattcagttc aatggtgata ctgcttttag ctgtcgtttc ttctcccggc tccagcactt 1666981 gtaaaccagt gagtgacgaa ggtaaatcaa gattcactgc gtttgtcacc catgtgtaag 1667041 gctcagggca taaataccct tgttttccgt ccgcattgta tacaacccaa tgtttaaact 1667101 gttcatctgc cttataaata atgctgatat gtgcatgctg atgataaatg actgcctggt 1667161 tttctccgcc cctcttctga taagaagata aaaagacatc atccagctgc ttgtggcgca 1667221 aatccattcc ttcatgcaaa gcttctttat acgggacatc catcagcttc ccggtcggca 1667281 gcaggcgttc atccaactcc cattgctgat ctgctgtcag ggagaataac gagctttctg 1667341 ccggaaatat aaatgtagta tgataaccaa ttccccaagg aaacgcttcc tttcctttgt 1667401 tcatgaccgt cgcatgttta aatagggtat tctccttgat cgtgtatgtc atccgaacga 1667461 cggcatgatg aggaaattgc ttctgcacat ggggaagctc agaaagatca atttctgttt 1667521 caacaatcac tccttcatca gtttgcttcg tggtcacgac attccacttt tcatggtaaa 1667581 gaaacccgtg aagatggttg tgtttatcct tctcgttgat atcaaaatga tacgttctgc 1667641 cccggaaact gaatgtaccg tcacttatgc ggttaggcgg gaacaggatt ggaatgccat 1667701 acaatgttgg tgtgtcgtga aaactttctg ctgtttccgg ttcacgcaaa agctggacat 1667761 ttgttgtttt gtccacgaga gaaatgacgt tgctccccca ctcagggaca acaatcattt 1667821 ctagatgttc gttgcccgct ttgatggccg gcgttcccaa atacgtgatt ttctcaataa 1667881 agtttgccat gtttactcaa cctctccttg attcattgct agtataagaa ttcaatgtac 1667941 tgtaccatat ttcctccatt ttatattttc ccctatcaaa taaaaaaaca ccgttcaaac 1668001 ttatgaacgg tgtgattcgg aggctattgg atgagacgtg tgatttgttt ctttttccag 1668061 acgaattgat aatacccata aatcaacagc aagctgacgg caaacgcagc tggataacca 1668121 acccagacgc cgagtatttc aagctttgta tagtgagaaa ggacgaaagc gacaggcacc 1668181 tctactcccc agattgcaaa aatactgatg acggtcggcc ataaaactgt tccgcttgcc 1668241 cgcatcgttg cagaaataat ttgggcattt ccaaacagca aatagctcca cagtgtaatc 1668301 atcaaaagac ggtgcgcaat gtaaagcgtc tcttgctcgg ttaaaaataa cgataaaatc 1668361 tgatgtgaaa aaacatagat cagaatgatc agtacgccgc caatgatata attcagccaa 1668421 atcccaacgc gaatgacctg ctttaagcgg tcaaactcgt ttgctccgat cgattgcgca 1668481 gcgaaaatag aaaccgcaat accaaggctg acggccggca tctgtacata gctggccacc 1668541 tggttgacca ctccgtatgc agctgttgca ttagagccgt aatgattgac gaatgaaata 1668601 accgctatct ctgataatga gacaagaatc atattgatgc ttgctgggac cccaagacgc 1668661 agcaggagaa ccagcagttc cttatccatt ttcaaataac gacgcactgt tttatcaaat 1668721 tgcagcgggt gttttcgctt tcgtaaatac accattaaca cgagaaaagt cgcaatcgtg 1668781 gaaatgacag ttgcatatgc cgagccgtat atgcccagtt tcggaaaacc aaacatgcca 1668841 aggattaaaa caggcaaaag cgcgatgttg atgaccgtgc tcacaatcag cgtataaaac 1668901 ggtgtcttgg aatctcctgt tccgcgcaaa aaggtagtat atgcaaaata taaaaacata 1668961 aacggcatag cataaaataa aatacgtgca tagttagcgc tgacatgaat gacattttca 1669021 ggtgttccca ttaaacgaag gatatccagg gtgaaaatac tgccgataac ggctaacaca 1669081 acgcctaata aaaatgtaaa cgtgagtgtc gtcccgacaa cagcctttag ccgttcctca 1669141 tttttcgctc cgtaagcttg tcctatcaga atcgaacttc ctgaaccgat cccaatcgta 1669201 aatgagatta aaagaaaaaa taacgggaaa aaggatgata cagctgccac tgcatcaaca 1669261 ccgagccatc tgcctacagc catcatcccg actagctggc cgactgattg cagcacattg 1669321 ctcagcagaa gcggcactaa aaagagtgac atcgaccgcc aaactgatgg tttgcttttc 1669381 ttttgagtta caagaggttc ttgtgatgtt tccatattaa aggactcctt tatttgaaat 1669441 cgtttttaaa catgccctca ttttttgaca aaaacaggat atgtaacatg ttattattca 1669501 tcactgcact tatgaaaccc ttcccgattc ttctaatttt acacatcttt ttagcttatg 1669561 aagaataaac tagcaagtaa tggcgtattt tttgtgagta aaagaataaa aaataattta 1669621 tgcaaaagta ttgtaatcta tccgtaatta ttgtaacatt tgtaacataa gagaaagaga 1669681 ttttgaagga gagagcgata atgaaaaaat gtcttctatt tctaacaacc attgcactta 1669741 ttctgtcatt aagcacaaat gcatttgcga aaaatacatc aggcgattta tcacaaaaac 1669801 aagcattaca gttggcatta tccgctagag aacatttttg gaacaccatg agcggccaca 1669861 atccgaaggt gaaaaaagca gtttgcccat caggcacatt cgagtatcaa aatcttcaat 1669921 atgtatacat gtgcagtgat ctaggcacta aagcaaaagc ggtgaattat ttaactccta 1669981 tttttacaaa aacagcaatc gaaaaaggct ttaaagatta tcatttcact gtttcaaaag 1670041 gaaaacttgc tgttccaatc ggtgacggag acaatctttt gaattggaaa aaatcaactg 1670101 ctaaactgat ctctaaaaaa ggcagcacaa tcacatacga atttactgtc cctacattag 1670161 acggatcccc ttctgcaaaa cggaaagtga catttgtgaa agaaaataaa aaatggaaag 1670221 tcaatcaatt tgacgcagtt atataagaaa aacgcccggt ataagcgggc gttttttatt 1670281 tggtttgcat aaagaaagac aacaggcgaa aagtgcctgt tgtctttttg tgaatataac 1670341 gctctaggag agattcgaac tcccgacctg cagtttagga aactgctgca ctatccgctg 1670401 tgctactaga gcttttggta tttatatagt agctctgatg atcaatattt tcaagcgatt 1670461 tgtattaaag ccctccaaaa accttatatg cggctcttgt cgtatcttca tcaataccga 1670521 tataccgcat tgtaattgat ggtgatgaat gattcagtat tctctgcagc tcggcgatgt 1670581 ctttcgttcg ctgataaaaa tgatagccaa acgttttccg gagtgtatgc gtccctatct 1670641 cctcaagtcc gcacgctgca gcggcctctc ttaaaattct gtaggcctga atgcgggaaa 1670701 tcggcttcct ggtccgcact gatttaaaaa gatattcgtt ttccttcatg tctttcgtat 1670761 actcgtatat ttcctgtttc agcgattcta aaataagaat ctttcttttc tttttcgttt 1670821 tgctttcagt cgcccataaa tgatctttat tttgaacgtc cttcacttgc agcggcagaa 1670881 tatcagaaat acggagcgcg ctgttgatgc cgaaaataaa cagaaaataa tcccgcttgt 1670941 ttttgttaag caaatactgt ttgacttctt ggattttctc tagactgcga atcggctgta 1671001 caatatgcat caaaaaactc cttaaaaacc gttatgtaac attttgaggt ctatgttact 1671061 attatagctg aaaaacgttg aatgtcaaag tgcggcggcg tttatgtaac ataatataca 1671121 tagtgttaca taagctttta aaaaagcttc ttccaacctt caccctataa aataagcttt 1671181 aaagcctctt ataaagcttt taacctcttg gatacttatc cccctactaa tcatcaaaaa 1671241 acctcttaaa atgaaatctg acactcccaa ttttctggag cttccgcaaa aatatacaaa 1671301 aaaagacaca atttcaaatt gtgtcctaat cctcatcctt tacatcaata tcttccggga 1671361 tcggttcatt taatatttcc tgcacaagtg ctttgtaatt ctccagctgt tcgagatgcg 1671421 ttttgaactg ttccttataa atcaaaaatt gctccccgtc atgaacggct ctgattttcc 1671481 cttcgagcac caagctttta atataatcct ctgaaagatt tgtatattct gctgtttctt 1671541 caatcgttaa atacatatag cagtcccttc ttaatccgta tgctgattct aatatagcac 1671601 atggctcata tcaatataat caattctgca cagaaaaacg gcattatgca ctatataata 1671661 taccatttgt cacttgtgaa aacgctgtaa tttttttacg ctaagattgt aacaatacag 1671721 cttcatatag gagggagaac atgaaaagaa cgtggaacgt ctgtttaaca gctctgctta 1671781 gtgttctgtt agtcgctgga agtgtccctt ttcacgcgga agctaaaaaa ccgcccaaaa 1671841 gctacgatga gtacaaacaa gtagatgttg gaaaagacgg catggttgcg accgcacatc 1671901 ctcttgcttc tgaaatcggt gctgatgtgc tgaaaaaagg aggaaatgct attgacgcag 1671961 cggttgccat tcaatttgca ctcaatgtaa cagagccgat gatgtcaggt attggcggcg 1672021 gcggttttat gatggtgtat gacggaaaaa cgaaggatac aacgataatc gacagccgtg 1672081 agcgtgctcc agcaggcgca actcctgata tgtttctgga cgaaaacggc aaagcaattc 1672141 ctttctctga acgtgtaaca aaaggtactg ccgttggtgt tccaggcact ctgaaagggc 1672201 tggaagaagc cttggataaa tggggaaccc gttcgatgaa gcaattaatt accccttcta 1672261 ttaaactcgc tgaaaaaggc tttccgattg attcggtgtt ggcagaggcc atttctgatt 1672321 atcaggaaaa gctttcacgg actgccgcaa aagatgtatt tttaccaaat ggcgaaccgc 1672381 ttaaagaagg agataccctt attcaaaagg atttggctaa aacatttaag cttattcgct 1672441 ccaaaggcac tgacgctttt tataaaggaa aattcgccaa gacgctttct gacactgtcc 1672501 aggatttcgg cggatcaatg acagaaaaag atttagaaaa ttacgacatt acaattgatg 1672561 aaccgatttg gggagattat caaggctatc aaatcgctac tactcctcct ccaagctccg 1672621 gcggtatttt cttattgcaa atgctgaaaa tccttgatca ttttaacctt tcacaatacg 1672681 atgtccgctc atgggaaaaa tatcagctgc ttgctgaaac gatgcatttg tcatatgccg 1672741 accgtgcgtc ttacgcaggt gatcccgaat ttgtaaatgt tcctctcaaa ggcctgcttc 1672801 accccgatta tattaaagaa cgccagcaat taatcaacct agatcaagtg aataaaaaac 1672861 cgaaagccgg tgacccttgg aaataccaag aaggatcagc aaactataaa caagttgaac 1672921 agccgaaaga caaagtagaa ggccaaacaa cccactttac agttgctgac cgttggggaa 1672981 atgttgtttc ttatacaaca acaatcgaac agctattcgg aacgggtatt atggtccctg 1673041 attacggtgt tattttaaac aatgaattaa cggattttga tgcgatacca ggcggagcta 1673101 acgaagtaca gccaaacaaa cggcctttaa gcagcatgac cccgacgatt ttatttaagg 1673161 atgacaagcc tgtcctcacg gttggatctc ctggcggggc cacaattatt tcatccgttt 1673221 tgcaaaccat tctctaccac attgaatatg gtatggaatt aaaagcagct gttgaagagc 1673281 cgagaattta cacaaacagc atgagctctt accgttacga agacggagtt cctaaagatg 1673341 tcctcagcaa gctaaacggc atgggccaca aattcggcac aagtccggtg gatatcggaa 1673401 acgtgcaaag tatatcgatc gaccatgaaa acggcacctt taaaggtgta gctgattcaa 1673461 gcagaaacgg cgcggcgatc ggcattaatt taaaacgtaa ataaataaaa aactgtactc 1673521 gcttcaaatg agtacagttt tttcatgcag atctttaaaa taaaaactga caaacgtctt 1673581 tattctgcta atgcacgtct atcttcatct tttcatttcg tttatctcat caagaaatgt 1673641 ctgaaacgca ctcgtaataa aaaagtcttt cctgtatata aagacgatct ctaagtcttg 1673701 atatgatggt ggcagctgat gaatccatac atttgtacga tgctcggagc cgtcaacagc 1673761 ggactttggg agcagcgccg tacccatccc ggcggaaaca ccttttataa tagcctccaa 1673821 tgtgccaaac tctatgattt tttgattgtg tatgcctgct tcctctagta atcttttgac 1673881 cctgtcacga tgagaacagc cagccccaaa aaagagcatc ggctgctgaa gcatgtcttc 1673941 tgccgtccct tctcgtgatg aaatcaaaac taattcatca tgggagacat ggagttgtct 1674001 aactgcagcg tgttcaaccg gcccatatac aaaagcgcca tcaactttat gatcaagaac 1674061 ctgttgaatc aaatgatgcg tatcagctgt gttcactgat aaatccactt caggaaaacg 1674121 cctgaggaag gatgctgcat gctcaggcag atgcgttacc gccattgttt ccagtgatcc 1674181 gatccgcaaa ggcccttttg gttgcctgct cattcgggtc gatttttcag cttggtctaa 1674241 cagcgataat acttgatctg catattgtaa aagattttct cctgcagcag tcagcttcat 1674301 tccccgattc gttcgatgaa aaagcctgat attcaaatct tcctcaaggt tatgcactct 1674361 ggctgtcaca ttcgactgaa cataattcag catttgggct gctttcgtta tgcttccttc 1674421 gcgagcaaca gcctgaaaaa tctttaaatc tccgctttcc acgcgctctc acctgcttgc 1674481 tatgatgaaa agtgatattg gctatcatat ttgttcattt tactcgaaga aaaccgctat 1674541 gtaaaatatg taaagatatg aaaatacaat taatgaggag gcagacagca tgaaagctgt 1674601 aattcacaac ggaaaagccg gtcttctggg gttatcagtt caggacgttc catcaacaaa 1674661 gcctggatac ggagaggtaa aggttaaatt aaaatctgca ggcctgaatc atcgtgactt 1674721 gtttcttatg aaaaacaaat ctgaacaaga tcctcacatg atactgggtt ctgacggcgc 1674781 gggtatcatc gaagagattg gtgaaggcgt gaaaaatgtt actgttcaga cagaagtagt 1674841 cattttcccg acattgaact gggatttgac agaaaatgtt ccacctgtac ctgagattct 1674901 gggaggtcct tcggacggaa cacttgctga atatgtgatc attccttcac aaaatgcaat 1674961 caaaaaacct gcttatttat cttgggaaga agcgggcgtt ttacctttat ccgctttaac 1675021 tgcatatcgg gctctgttta caaaggggca attaaaaaaa ggcgagcatc tattgatacc 1675081 cggcatcggc agcggtgtag caacctacgc tttatttatg gctaaggcga ttggggcaac 1675141 agtaagcgtg acctcccgca gtgaggagaa aagaaaaaag gcgctgaaat taggtgctga 1675201 ttacgcattt gacagctaca gcaattggga tgagcagttg cagggaaaaa agatagatgt 1675261 tgttcttgac agcataggac ctgccctctt ttcggaatac ttccgccatg taaaaccaaa 1675321 tggccgtatt gtcagctttg gggcaagctc aggggataat ctcagttttc cggtgcgttc 1675381 tttattcttt cctcaggtca atgttttggg aacctcgatg ggaagcggtg aggaatttca 1675441 agctatgctc gctttcattg acaaacataa gctgcggcct gtaattgacc ggatatatcc 1675501 tttagaaaaa gcatgtgaag catataaaag aatgcaggaa ggcagacagt ttggaaacat 1675561 cgggatcgta atggaataaa aaaagaaacc ggctggcagc cagaccggtt tctcttatat 1675621 gataatcccc tttatttacg gaagaactga actccccatc aaatatcgat ccacttcacg 1675681 cgccacttca cggccttcat taatcgccca tacgattaag ctttgccctc ttcttgcatc 1675741 ccctgcggcg aatacaccat cgatatttgt ttgataatcc ccatatgctg cactgatttt 1675801 gttatttact gaattaacac cgaactgttt caacagcggc tgttctgtgc cttcaaagcc 1675861 gatagcgata aagacaagct gagcaggcca tactttttcc gttccaggca gctcgcggaa 1675921 ctcgtatttt ccatgctcat ttttcacttt ttccatttgg atggtatgaa gctctttcag 1675981 ctttccgttt ttatccgcga ccatttttgt cgtttgaatg gagtattctc tcggatctct 1676041 tccgaatttt gcttctgctt cctcgtatgc atattcaagc gtaaagacgt gtggctgttc 1676101 aggccacata ttgtcattcg tgcgggctgg cggaagtttc gggtgtttgc cgaattggtg 1676161 cacgcttttg gctttttgac gcagagcggt agccacacag tcagctcctg tatctccgcc 1676221 tccgattacg atgacatctt tccctttggc atcaatgaat tgcttgtctt taaaattaga 1676281 atctaaatag ctttttgttg caagtgtgag gtagtccatt gcgtaatgga ctccttttga 1676341 gtcgcgtcct tcgattaaga ggtcccgctg tttttgagcg cctgtgcata agatcacagc 1676401 atcaaattgc tcctttagct catcagctgt aatgtcaaca ccgatttctg tgttcgtgac 1676461 aaaatcaatt ccctcttgcg tcagcaattt aattcggcgt tctacaatgc ccttctcaag 1676521 cttcatgttt ggaatgccgt atgttaaaag gccgcccgct ctgtctgctc gttcaaaaac 1676581 agtgacggaa tgtcccgctt gattcagctg gtcagcactc gccagtccgg ctgggcctga 1676641 cccgacgatg gccacttttt tgcctgttcg tttttttgga attctaggtt gaatccagcc 1676701 gttctcaaat cctttatcga taatggtccg ctcgatgttt ttaattgata cggccggatc 1676761 tgaaatcgct aaagtgcatg atccttcaca aggagcgggg catacccgcc ctgtgaattc 1676821 aggaaagttg tttgttttca acagacgttc caatgcttcc ttccatctgc cccggtagac 1676881 aagatcattc cattcaggaa ttaagttgta aatcggacag ccggatgtaa atccgttaat 1676941 gtccgcaccg atctggcaaa acggtgtacc gcaatccata caccgcgccc cttgccgttt 1677001 cgatgcttct tctgaaaaag gagcagaata ttctttccaa tcctttaagc gagtgagagg 1677061 gtcccgctcc gcaggttttt ctcgtttgat ctccataaat ccagttggtt tccccatgtt 1677121 cctctcccct tccttactgt actaccgctt gtttttgtcc cgatgctgct gtattctgct 1677181 ttggcttcgt gttggcctca aaagcgaaca tgatggcttc ttcatctgat aaacctgcag 1677241 ctttttgctc ttcgatgctt gcgagcattt gtttatagtt tttcggaatg actttgacga 1677301 attttttcac actgtcttcc cattgatcta gcagatcttc tgctttttgg ctgtttgtat 1677361 acgcagtatg tctttcaagc attgctttga tttgctggat ttctttctca tcctctaatg 1677421 attcaaataa aatcatctca aggttgcatt tgcgtttaaa cgctttgaca tcttcggtca 1677481 gtacataagc gattccgccg gacatacctg ccgcaaagtt tttgcctaca tcaccgagaa 1677541 cgacaacgct gccgccagtc atgtattcac agccgtggtc gccgatgcct tctacaacta 1677601 cgttcacacc gctgtttcga acggcaaagc gttcaccagc acgcccgtta atatatgctt 1677661 ctccgcttgt cgcaccgtaa aaagccacgt tgccgataat gacattgtca tccgaagcag 1677721 agttgaatcc ttctgatgac ttgacgatga tttttccgcc agaaagccct tttccgacgt 1677781 aatcatttga gtctccgtcc aaataaagcg tcatcccttt aggaacgaaa gctccaaagc 1677841 tttggccggc tgatccggta aagtgcagct tgattgtatc ttcaggaaga ccttcttctc 1677901 cgtaacgctt tgagatttca ctgccggtta tcgttccggc tacacgattt gtattattga 1677961 tttcaatcga aatatcagct tcttttccag attcgatggc ttcttgtacg gccgggagaa 1678021 ttgttgtaat atcaagtgat tgatcaattt tatgattttg cggcgattgg aacgtccgca 1678081 ccccttcagg ctgataaaga agggtagaca aatcaagctg gcttgctttc cagtgctcct 1678141 ttgcccgttc acttgcatga agtacatcag tgcggccgat catttcatca aatgtcttga 1678201 agcctaacgc agccatgtac tcacgaactt cttcggcaat gaacagcata tagttcacaa 1678261 tatggtcagg atctcccatg aactttttgc gaagctctgg attttgtgtc gctacaccga 1678321 cagggcatgt atccaaatgg caggcacgca tcatgacaca gccgagtaca actaacggag 1678381 ccgttgcgaa accaaattct tcggcgccga gcaaggcagc catcacaacg tcgcggcccg 1678441 tcatgagctt tccatctgtt tctaatacaa cacggtcacg aagtccgttc agcattagtg 1678501 tttgatgtgc ttctgcaagg ccaagctccc acggaagccc tgtatgttta atactggttt 1678561 tcggagaagc gcctgtacct ccgtcatagc cgctgatcac aatgacatct gcagtcgctt 1678621 tggcaacacc tgcagcgatt gttcctacac ctgcttttga caccagcttt acgctgattc 1678681 ttgcgtcacg gttggcattt ttcaaatcgt ggatcagctg ggctaaatcc tcaatcgaat 1678741 aaatgtcatg gtgtggcgga ggtgagatta atccgacacc tggcgttgac ccacggacat 1678801 cggcaaccca tggatatacc ttgttgccag gaagctgccc gccttcaccc ggcttagcac 1678861 cttgagccat tttaatctgc agctcatcag cattgacgag gtaatggctt ttgacaccaa 1678921 accgtccgga tgcaatttgt ttgatcgcac ttcttctatc atcgccgttc tcatctggaa 1678981 caaagcgttt gggatcttct ccgccttcac cgctgttgct ttttcctcca agacggttca 1679041 ttgcgattgc taaagcttcg tgcgcttcct tactcaagga cccgaatgac atcgcacccg 1679101 ttttaaaacg tttgacaatc gattcagcgg attcaacctc ctccaacttc aaaggcttgc 1679161 ggtttccgtc aaatgcgaac aagttccgca aaaatccgat gcgttcttca tcagccgctt 1679221 ttgtatactg tttaaacaga ttgtaatcat ttctgcggca cgcccattgc aaagtatgaa 1679281 tcgttttcgg attaaacgca tgatgctctc cgccatttct ccattggaag tcacttcccg 1679341 gttcaagcgt tttgctgtaa tcatcctgat acgcttcccg gtggcggcgc tgtgcctctt 1679401 ctgcaattgt ttgtaaatcg atgccgccta gctgtgatgc agtacctgag aaatagcggt 1679461 cgatcacatc gcggctgatt cctaccgcct caaagatttg tgcgcctctg tagctttgca 1679521 cagttgaaat tcccatcttg gacatcactt ttacgacgcc ctcagtaatg ctttttccat 1679581 atttgctaac cgcttcttca tagctgatat ccaaacggcc ttcatcaatt tcctgcttgt 1679641 aggtcgcata agcgagataa gggttaatcg catctgcgcc ataaccgatt aacgctgcaa 1679701 agtgatgcac ttcacgtgct tctcccgatt ccacaataat gctgaccttc gtacgcagcc 1679761 ctttgcggat taagtgctgg tgcagtgcgc ttactgccag aagcggcgga attggtgtca 1679821 gtcgttcgtt catctttttg tctgataaaa ttaacaaact tacgccttgg ctgatggctt 1679881 tctctgcctg tgtgaacatg tcctttaaac cgcgttcaag atcctctgaa aacagcacat 1679941 caattttttg gctttttaaa tcaggatgaa caatcgtttt caatgcgtaa aactgttcat 1680001 tggataaaac aggtgtatac agtttaatcc ggcgaacatt tcgttcactt ggatgaagaa 1680061 gatcgccttc cgcaccgagc caagtcatcg ttgaagtgac aagctgctca cgaatcgcgt 1680121 cgattggcgg gttcgttact tgtgcaaaca gctgtttaaa gtagttaaac agcgattgcg 1680181 ctcggtcaga aagtacagca agcggagcgt cattccccat tgaaccaagg ggatctttgc 1680241 cttctttaat aacaggaatt agatactttt ggatatcctc atatgtgtat ccgaatgcct 1680301 tctggcgagt aagaagatca ctaaattgtt cttcttctct tgactccgga tcaggattta 1680361 cttgtacaag ctcttcttca agccattttt ggtacggata ctcagttgca atttgtgttt 1680421 tgacttcctc atcggagata atacggcctt cttccaggtc gattaaaagc attttcccag 1680481 gctcaaggcg gtttttatat aaaacgttct cctgttcaac ttcaataacg cctacttcag 1680541 atgagaaaat aatataatca tcttttgtga cataataacg ggccggacgg agaccgttcc 1680601 ggtcaaggat cgccccgatt tgtttaccgt cagtaaatga aatagctgtc ggtccgtccc 1680661 aaggctccat cagggagcta tggtactcgt agaacgccct tttttccttg gacatatgcg 1680721 tattttccgt ccaaggctct ggaatgagca tcattgccgt atgtgccggt ttgcgtccag 1680781 ccatcacaaa aaactcaaat gcgttatcca aaatggaaga gtcactgcca tcagcattga 1680841 gaatcggcaa aatcttgttt aagtcctcac cgaagctttc agaaacaaat tgctgctcac 1680901 gtgctctcat ccagttgata tttccgcgaa gggtgttaat ttcaccgttg tgaaccaaat 1680961 agcggttagg atgcgctctt tcccatgtag ggaatgtatt ggtactgaag cgtgaatgaa 1681021 caagcgcaaa agcagaaacg aatgcttcgt cttgcagatc agaataaaat gcatcaacct 1681081 gttcaggtgt taaaaggcct ttgtaaacaa tggtctggct tgaaagactg gcaaaataaa 1681141 aatcaagacc ttccgttact ccccaatttt cagcctgttt acgaatgaca tacaattttc 1681201 gttcaaaaga taaattgtcc tttagatcag aacttgcgcc gataaatacc tgacggacaa 1681261 acggacagct tttttgcgcc actgttccga tttttccgac atttacaggt acagttctcc 1681321 atccaagaac gacttggcct tcttgttcaa ttagtgcatt gatttgcttt tcaatttttt 1681381 ttctttcatc ttccttctgt gagaaaaaga ccattcctac cccgtaacgt tctttttctg 1681441 gcagattgat gtttttgcac tcttttctaa agaaagcatc agggatttga accagtaagc 1681501 cggctccgtc tcctgtatcc ggatcactgc cttgccctcc tctatggtct agctggcaaa 1681561 gcatcttaag tccttgtttg acaatgtcgt gagtctgctt gccctttaag tgtgcatata 1681621 ggccgattcc gcatgcatca tgttcaaatt caggacggta gagaccttga gcttttggca 1681681 tttgattgta cgtcataatt cctctccccc gatcaatttc cgataatacc ggtcataaaa 1681741 tctaacaact ctataatcat tgtaggtttt caaaacgata taaacaatat ataatttaga 1681801 tcaaaagaat ctcaaaatga gatagatgga tgtgagacaa acatggagct gcgccaactg 1681861 cgttatttta tggaggtggc tgaaagagaa cacgtttcag aagccgctga tcatttgcat 1681921 gtggcccaat cagcaatcag cagacaaatt gccaatcttg aagaagaatt aaatgtgacc 1681981 ttatttgagc gtgaagggag aaatatcaaa ctcacgccaa tcggaaaaga atttttaatt 1682041 catgtgaaaa cggcgatgaa agccattgat tatgcgaaag agcaaattga tgagtatctt 1682101 gacccgcatc gcggaacggt aaagatcggc tttcctacaa gcctcgccag ccagcttttg 1682161 ccgactgtca tttcagcgtt taaagaagaa tatccgcacg tcgaattttt gctgcgccaa 1682221 ggctcctata agtttctgat tgaagctgtc agaaaccgcg atattgatct ggccttatta 1682281 gggccggtgc cgacgaattt ctctgacata acgggaaaaa tattatttac tgaaaaaatt 1682341 tacgcgcttg ttccattaaa tcatccgctt gctaaacaaa aaacggttca tttaatcgat 1682401 ttgcgcaacg accaatttgt attgttcccg gaaggatttg tacttagaga gatggcaatc 1682461 gatacttgca aacaagcagg ctttgctcct ctcgtttcca cggagggtga ggatttggat 1682521 gcgatcaaag ggttagtgtc cgcaggaatg ggcgttaccc ttctgcctga aagtactttt 1682581 gctgaaacaa cacctcgttt tactgtgaaa attccaattg agttccctca agtaaaacgg 1682641 actgtcggaa tcattaaacc gaaaaataga gagcttgcgc cttccgcgaa tgatttttat 1682701 gagtttgtca ttcaattttt ctctaagctg gagcagtatc aataaaaaaa atgaacccga 1682761 gcttctatat agaagcttcg ggtttttttc tgcaaattaa tttacaggta aagaaaaatc 1682821 cacatggcaa acaaatgctt cttgatcaat tagagctcta tttgtcagtt cctttttctt 1682881 ttccggttct tgaagctgta cagaagagta attgacgatt ccaaggccga tttccgtccc 1682941 ttttgaatcc atcagccgaa caactgaacc gcttttgaat ttccctttaa tcttctgtac 1683001 accgtctagg tataaactcg attgtccgtt tgttattttt cgtgaacaat catctgataa 1683061 aatcatttca ccttccggac cggaattaaa agcgatccat tgctcctttt gattcaacgg 1683121 aagcgttcct tctgcttcaa aataggtgcc ttccgcctgt tcatgaacgg cgtggtataa 1683181 aatatcgcca gcatctgcct gacctaggaa acctttaatg ccagacgcca ttacgatttt 1683241 aaacgcatca agcttagagc gcatgccgcc ggtgccaacg atgcttccag tgtcacctgc 1683301 gcatgcttcg atgtcaggtg ttatttcact cacccgctgt atctttttcg cttctggatt 1683361 tgtgcgcgga ttgccgtcat ataatccgtc tatatctgat aaaatcacaa gcatatctgc 1683421 atcaatcaat cctgcgactt ttgctgcgag cgtatcattg tcgccaaact tgagccgatt 1683481 gacggtaact gtgtcatttt cgtttatgat cgggatgatg ccgcgctcga gcagtacatt 1683541 cattgtattc ctgacattgt tgtatcgata ttcatcagaa aaatcgcttc tcgtaattaa 1683601 aatttgggat gcgacatagc cgtgtgccaa aaacagcttt gaataagcct ccattagcaa 1683661 tccctggccg attgaagctg atgcttgttt ttctggaagc ttctcgggcc tttggataaa 1683721 tccgagcttc cgatatcccg ccgccactgc gcctgaggaa accaaaatca cttcataacc 1683781 ggcgtctttg agtttgacga cctggtcgac caacgcttct aattttcgaa tgctgatttc 1683841 tccatgaagg cttgttaatg aactgcttcc aatcttcaca acgactcttt tcatgcttgt 1683901 atcaggcgtc actttatcac tcctgatagc ggcgctgcag ttttttcgat atcttcgctg 1683961 atttcctttg aacgcttagc cgcatgcttt attgcttgag aaatcgcttc tccgccgccg 1684021 ctctttttca aggcttgcag ccccgctgct gtcgttccgt tcggtgacgt gatattatct 1684081 cttaagatct caggatgttc tcctgtttcc atgagcattt ttgcggcacc taaaagtgtc 1684141 tgtgcgccga tgcttcgaga taactgttta tcgaggcccg cttcctcgcc tgtcttttca 1684201 atgaattcca ttaaataata aaaatacgcg ggtccgctgc ctgcaattcc ggtgaatata 1684261 tccatttgat tttcttggat tgtatagact tcgcccatgc atccgagcaa tgcttcggcc 1684321 agcttcttca ggtcttccga cacatatttg ccaagggcaa tagctgttgc agaagcgcca 1684381 atcatactgg aagtgttggg catcactctg acaaccggct gttcattaag caatgattgt 1684441 tcaataaaag aggtagttat gccggcaagg accgacaata ttaattgatg gggttgaata 1684501 cgtgatttta gtgatgacag agcgttttcg gcgtcttttg gcttcattgc caaaatgagc 1684561 acatccatgt cttcaataca tagttggttc ggcaaggcgc ctttaatgcc atattgaagt 1684621 tcaagttcag ttaatcgctc tgtattgctg cggtttgtaa cgcagatgtt ttgtttcggg 1684681 attttgttgg ctcgaacgat acctgatatc attccttccg ccatagatcc tgctcctata 1684741 aaggctactt tcttttgatc aaagatcggt aacatctcct ttgttcgctt ttttgttcgc 1684801 attttcacac gtttaaaatg ttaccacgtg aggaaatgat gtcaagtttg aaggccatta 1684861 ttgatttgta ttgtttcttt tcgacaaata tgtataatga aaagcagaaa acacccggtt 1684921 cacactgctg cgccgggtgt ttgtttctat taaaaattat ctgagagagc tttttcaatc 1684981 agttttttac agcgatccag ctctaccttc agctgttttt tatatagctt ggcagcttcg 1685041 taatctttaa attgatagag gacgacttcc tggagcttag ccccttcttt ttttacttta 1685101 atttgtttta gtatcccgtc atcaagaagc tcatgcaaag accggtatac ttctgtatga 1685161 tttggtttaa aaccaatctc tttaaattca gaccgaagta cttcaagcag ctttaaccca 1685221 tagagtctct cttgctctgt catcgttatc atataaagct tcaaaaatgc gcgctgtttc 1685281 actaaaaagc ctgttgaact ccttttttct tctttcatca tatgcactcc ttcttctgtc 1685341 actgacaaca ctatgtacta aatattcaat tttcttttat tgttttcctt ctttatatta 1685401 aagactgata gtccagttat ttcatgttta ctgattatag gtgtagcgga aaaaataaat 1685461 ttcgactgaa catttggtac atagttttct tagttctatt atagcctgca tttactgcta 1685521 tcttcaattt aaacgattgc cagggtttac atatctcatt ttaccggtac ggatttcatt 1685581 caaataaaaa aacctgtcga aagacaggtt ttcattttta aggatttgtt gaccataatc 1685641 ccgctgtttt gatgaaaata cgaggatcta atttcagttg tgccaccatg tactcagcaa 1685701 gatcctcagg ctgcataact ttttcaggat taccgtctgt taagttcaat tcgatagaca 1685761 tatcactagc gacagtgctc ggcgttaacg cgctgactct gatattatgt tttctcactt 1685821 cttgcataag agactctgtt aacccgagaa cggcaaattt agaagcgctg taagcacttg 1685881 ttacagcagc tcctctttgg cccgctgtag atgaaatatt aatgatgtct ccggctttgc 1685941 gttcgatcat ttccggaagc accgcgcgag tgacatggta cacacccatt aggttgactt 1686001 gaataatatt ttcccactca tcagctgaca gatctaagaa accgccaaat ttgctgatgc 1686061 cggcattatt aatgaggata tcgatatcac cgagctgttc cttcacttga gctacagctt 1686121 ggttaacctg atcggcatct tttacatctg cagcagcaaa tgcagctttt acaccaagcg 1686181 ctttgacttc ttcagccact ttttctacat tagcggaagt ccggccaatt aacccgatat 1686241 tcacgccttc tttggcaagc gccagagcag tagcgcggcc aattcctctg cctccgcctg 1686301 tgattagtgc agttttatgt tgtaaacttt gcaattgaag caccctttct ttgtttacat 1686361 atgtacgata tcacattata agtacaatac atccaatacg caaatcaaac gaactgtgta 1686421 aatatcattt cttctgatta aaaaaacgga tacagggtaa tgacataaga aaaggagtga 1686481 acatatgatt atagtttata tcagtcttgc agtattagca gtttctatta tcttcttagg 1686541 agttaccgtg atccaaaaca agaaaaaaat agaccccgca ctaaaggagc tttcctctgt 1686601 tacgcaggct atgcaaaaac aaatcgaagg attaaaaaca gaaacagagc tgctgacgca 1686661 aaaacaaaag aagattcagc aggatgtcca aataaaaaaa tacacgcttc agcagaccgc 1686721 agctgaagtg aaagaagttc cccaagcagt caaagaggtg tggcaggcag gacattttaa 1686781 tagcagataa ggatgaatga gatcccgttg ttacgatcag aatggacaaa tgggatctca 1686841 tttttcgagg aggcttacac atgattataa accgcagctg cttaaaagag ttcgcagaaa 1686901 aagtacattt tcttccctct tcacttacaa agtccgattt acttactgat ccatttcgtc 1686961 tccatcaaga aaacgaactt ggcatctact attcacctca taatgaattt atcaatcggg 1687021 atgcctcgct tgtgattgcc gggatcacgc ctggtttttc ccagatgaag acagcgtacg 1687081 aaacagccgc cgaaagcctg ctgcaaggcg ggactcttga gcaaatggca gtagacacaa 1687141 aaatagcagc gggtttctcc ggatcgatga gacataacct tattaccatg ctggatttat 1687201 gcgggctgcc gcaagctttt ggcattcaaa gcgccgcaaa gctttttgga gaattacggc 1687261 atatgctcca tacaacttcc gttattaaat atcctgtctt tatccagcaa aaaaactata 1687321 ccggatacaa accggctatc actcattctc ctatcctaag cacttatgct tttgggcact 1687381 tccctgcaga gcttaaccat gtgacgggac cagctcttct cattccgtta ggaaaagcgg 1687441 ccgaaacagt gtgtgaaaca ttgatcagac agcacagcct ccagaatttg atttgcctta 1687501 acggctttcc ccatccatca ggcgcgaacg gccatcgttt gaaacaattc agcaaaaaca 1687561 aagagcaact agaaagacaa attcgttcct ttgctgcatt ggttgatttc gctatagaaa 1687621 agaggaaata aaagggatat gataaacaaa aacacaaacg tggggagtgg ttgaatgttt 1687681 cctatattag aaacggatcg gcttatactt aggcaaatca cagatcagga tgcggaagcc 1687741 atttttgctt gtttctcaaa cgatgaggtg acacgctatt atgggcttga aaacatggaa 1687801 tctatagaac aggccatttc aatgattcaa acgtttgctg ccctctatca agaaaaacgc 1687861 ggtatacggt ggggaattga aagacgggac actaaagaac tgatcggaac aattggcttt 1687921 cacgctctgg cccaaaagca taggcgcgcg gaaatcggtt atgaaatcat cccggagcat 1687981 tggcgaaacg gatttgcatc agaagtcatt tcaaaggtcg tatcttacgg attttctgcc 1688041 cttggactgt cgcgtattgg cgcagttgta tttaccgata atgaagcatc aaatcgtctg 1688101 cttctaaaaa tggggtttca aaaagaaggc gttttaagac agtacatgta tcaaaatggg 1688161 actccatatg atacaaatgt gtactctatt gtgaaaccaa gagaatgacg gtattctctt 1688221 ggtctgtgcc acatcccttt tcctttaaaa agataaaaag cgcccctcaa acagggcgct 1688281 ttctaattaa gatgcatatt gaggagatgt ttcctcctta actgcttttt cctcaggtat 1688341 atgaatacat tttgtcaaga ccgcacttgc aaggtaaagg gccgcaaaga tccagacgac 1688401 accttgcgcg ccgacgagac cgatgaacag ccaagcgagt gcagggccga caaacgctga 1688461 taaacctgca gctaaattca atacagacat ggctgcccct ttatcttttc ctgccaccgt 1688521 cggcacaatt gcaccaatcg gcacatagcc tgccagcaaa ccgccccaaa taaagccgat 1688581 cacgctgaca accgctaaac ttccgccgga gaaaacaggt gcgtagtata ataagacggt 1688641 gaaaatgccg cagccgactc cgccgaacca aataacagta tttttccagc cgaatttatc 1688701 gccgacaata ccgaagataa ggttaaacac aatgttcccc aggaaaatcg ttccccaaat 1688761 ttgcagccac acattggttg aaattccatg ctgggccatg tgcatcggca aaaagactgg 1688821 aaaaccatat gtaccaatgc tgttgatgat tctgatgatt ccgcctgtaa gcacgcgcgg 1688881 atttgtaaat agaatcgtaa ccccttttaa aagctcctcg gctgtttctg atctttttct 1688941 tttcttcttt tcaaaacggt ctttattgat aaacaatgca aagaatgcac cgagacatac 1689001 ccagaaaata gagctccaaa gcgtattcaa ataaccgaac gctttgatcg cgtagcttga 1689061 gtaccaagcg ccgaacacaa acatgccgag gcaatatgca atccaaaacc agccgacagc 1689121 agtgctcagt ttgctttgcg gtgttctgta aatgacccat gtcaagaaag aataagcaaa 1689181 aagcgggtaa cctaaccctt ttacgaagta agtcacatac atcactggca ggttcagctg 1689241 ttcaaatcca aatacgataa aagcagctgt accgatcaca taaaacaaca gccccataaa 1689301 catcgttcgt tttgcgccaa atgcttcgag acatacaccc gaaaaccagg aagctatggc 1689361 aagcgcaatt ccgtatatac taaaaatgga agcggactgc tgaacggtga gcccgttttc 1689421 gatcaaaaaa ggactgagcc agccttgttc aaggccatct cccatcataa acaaaacaac 1689481 ccctaaaaat ccccaggcaa gccgcttcgg tattcctatt ttatccaaca tatctgtctc 1689541 ctccttagat gctattattc attaccgtat taccttatta aagttgaaaa ttaaatgatt 1689601 cctcaaaaca gcagaaattc cgtcttaaat taatactttg ctttctgatc ctgaaaaaaa 1689661 gcgctgtgtt tgcttccatt cctcatataa agccaattct atctgacagt ccttcggttc 1689721 gatcacccgg acatttgctg acatctcctc cgttaattga aaggtttcat tgcaaatgac 1689781 tgcagcaccg acgacagatg cctgatgata tccctcttgg acatagacct ttttttgaag 1689841 aagatccgcg atatattgag tgagcgcttt gctttggaat ccccctccgc acacccaaac 1689901 ataatcacgt tcaaacggag taacctctgt taaaatgtca aagttccatt tgattgaaaa 1689961 tgcgatctct tctagcgctg cacgtacaaa atgtgccctc tttaaatgtg ctgacagcgg 1690021 ggcatcaaaa agaaaaccgc ctctcgttaa cgcattcttt tcagccgata aataagagcc 1690081 gagagccgct acacatgcat ggtcttcttt tgcaagtgca gaaatctcct cctccattac 1690141 ttcgtacgtt tcattcggat aaaaaatctg ttttaatttt tgataattca agccggtaat 1690201 tcccggattc gtttccacaa gccaatgccc ttgatccgta tgacagttca accaggcttt 1690261 atgttttgtg tcgccatgat cctcagtaat tttggttatt ggcgttgttg tccctgatac 1690321 aatgacaatg tcctcaagtc cagctccggt gcttttgaca gccagctgtg tatccccgcc 1690381 ccctgctata accttagcat ttattgaaag gcctaattcg gatgcatatt catttgctat 1690441 cgttccaatt gctgttcccg ctcttacaag aggcggaagg atagatggag aaaagccgaa 1690501 aatgtcgcac atctcttctg accaagtgtt ttgcttcaca tcaaatagca gggtttctgt 1690561 tgcctgtgat ggttcatatg ttaatattcc gctcagttgg tacgtcaccc aatcactgat 1690621 gcttgtaaag cttgcagtct tttcccataa agagggctgg cgctgtttta atccataaag 1690681 cttgagcgca gaaaaaagtg cagttggcag gcggcctgtg ctgctgtata tctcttccca 1690741 atcgggaatg cccgcctccc actctcggcc gcgattatcg atgttcggca gcccgagaaa 1690801 aggattgccg ttttgatcaa tcaaaacaat cccctgtctt tggctcgtcg atgtcaaacc 1690861 aatgatgtca atatcacacg aacgggatag cgcacgtttt gccaaattca tcacctgctt 1690921 ccacagcacc tgaggagaaa aataacggct gtccgggtaa agcgtctctg tggaatactc 1690981 gatgtcctcc cgttcaactg ttagaacact gccagttaca ctcacgaccg ctaccctcgc 1691041 attgcctgtg ccaatatcaa aaacgagata gcctttttgt tttttcattc tgttagcctc 1691101 ctttcttatc cccctgtttt cagtgcgtcc ttgttataca ttgtctgaat attaagagtt 1691161 ttttcaccct tccacttttt gagggcttta ttcagtatcg tcacgtgatg atcctccact 1691221 tcaaatgttg ctccagcgag atgcggtgtt gccagaacat taggcaatga aatcaattca 1691281 taatctgatt cctctggagg ttcatgataa aaaacgtcta gtatcgcacc gctgatttta 1691341 tgttctttta atacaaataa aagatcttca cggtttacaa caactgctct tgaagtatta 1691401 acgaaaatcg cactctcttt catcagatca aaatattgcc gatctatcag tccgagtgtt 1691461 tcctcagtgc gaggcagatg gacagaaacg atatcgctgt ctgaaaacac cgttttaaga 1691521 gatgcttttt catacaacgg atgatcgtct tgaatgtatg gatcgtaata ttttatctta 1691581 cagtcaaacg cagtcagcag ttttgcaatc ctttgcccga ctgcgccgaa cccaatcatg 1691641 ccaaccgttt ttcctgttag ctcatttcct ttaaatttga cataagcctg caggtaatca 1691701 ctgtcccact ctccatcctt cagccactga ttcgaggcgc tggtatggcg cagaaaggaa 1691761 atcacatttc caataaacat ttcggcaacg gcttgtgcat tccgccctgg tgtataaaaa 1691821 acaggtatgc ccctttttga ggcagctgcc acatccacat ttgagggcat tcccctgcaa 1691881 acaccgacaa atgaaagttc gggaacagaa gcaaatacgc tgtctgttac ctgatcaagt 1691941 tcagtaatca agcctgtcgc atttgttgct tttagcagct gaatgagttc atcctcccga 1692001 tatgccctac cttgttcctt ccaagattga taagcaactg agccaaacaa gttttcaagc 1692061 tcttttcgtc cttcttcgtt gtacggtgct gtaaccaaaa ccgtcatgct gcaaaacatc 1692121 cttttcatcg tatttttcat aaaaaaaatc tctttccgaa gatggaaaga gattcatata 1692181 taggcgcgct ctgttacagg cagacgccgg tataaacctt gctttcctat ctttcaagct 1692241 agcgcttgct ggaattggca caataatgtt gccgaggttt catagggcca gtccctccac 1692301 ctctctggat agaaaatatt gagtatgtaa ttttcagaat gaagaatacg tttatcataa 1692361 agaagactca gattgatgtc aatctctttt tttcagaatt gacgttatca tcggaaatgt 1692421 tataattctt acaaaatatc taactagaga gaggaactgg gccatgagat cttttgccac 1692481 acaacaaaac ggcattttca aatccgtttg ctcgctggac tgcccggatc agtgcggatt 1692541 gttaatacat aaaaaagacg ggaaaatcgt aaaagtgcaa ggagaccctg atcatcctgt 1692601 cacagctgga aacatatgca acaaagtccg gaatatgacg gagcgcatct atgatgaaaa 1692661 gcggctgact acaccgctca aacgaacagg tgcgaaaggc caagcgatat ttgaaccgat 1692721 ttcctggaaa gaggcaatcg atacgatcac ctcccgctgg aaacagctga ttgatgaaga 1692781 gggagctgaa agcatacttc cttacagctt ttacggaaat atggggaaat tgacagctga 1692841 aggaatggac cgccgctttt tttaccgcat ggggtcaagc cagcttgaac ggacgatttg 1692901 cagcaaagcg ggatctgaag gctataaata tacaatgggc ataagcgcgg gaatcgatcc 1692961 tgaggaaacc gttcatacaa aactatttat tttttgggga atcaacgcgg tcagcacaaa 1693021 tatgcaccaa attacgatcg cccaaaaagc gcgaaaaaaa ggtgccaaaa ttgtcgtgat 1693081 cgatgtgcat aaaaatcaaa caggacgtct tgcagattgg tttatcccaa taaaaccggg 1693141 aaccgacagt gcacttgctc ttggcatcat gcacatttta tttaaagaaa accttcatga 1693201 tgaagcattt ctgtccgagt acacggttgg ctatgaagag ctccgtgaac acgtgaaaca 1693261 atatgatcct gaaaaggtat cgacgatcac cggtgtcagt accgaagata tttaccgact 1693321 ggcaaaaatg tacggggaaa cctccccttc ttttatcaga atcggaaacg gaccccagca 1693381 tcacgataac ggggggatga ttgtaaggac gattgcctgt cttccggcga tcaccggcca 1693441 atggctgcac acagggggcg gcgcaattaa gcataacagc ggaattttag aatataacac 1693501 aaatgccttg cagcggcccg acttattgaa agggcgcacc ccgaggtcgt ttaatatgaa 1693561 tcagcttggc agggtgcttt tggaaacaga cccgccgatt cgctctctat ttatttacgg 1693621 aacgaaccct gccgtcgtcg cgcccgaagc aaacaaagtc agacagggct tgctgcggga 1693681 agacttgttt actgtggttc atgatttgtt tttaacggaa acggctgcat atgcggacat 1693741 tgtactgcct gcaacatccg cttttgaaaa tactgatttt tacacctcct actggcacca 1693801 ttacattcag cttcagcagc cggtgattga gagatatggg gaaagcaagt ctaacactga 1693861 ggttttccga ttactggctg aagccatggg attcacagac caggagctta aagattcaga 1693921 tgaagtatta atccgccagg cgcttgacca tccagataat ccgcatttgg cagagattga 1693981 ttacgattca cttactaagc attcatttat gaaagcgaaa cgtgaaaagc cgctgtttcc 1694041 gggcgaactt ccaacgccaa gcggaaaaat agaattatat tcagaaaaaa tgaaacaaga 1694101 cggcttccct gctttaccga catatacacc tcttgtaacc gataatgaac atccgtttat 1694161 gtatgttccg gggccaaacc ataatttctt aaactcaaca ttttccaata atgaaaaaca 1694221 catcaagctt gaaaagacgc caaagctctt tatcaacaca aaagatgctg aaaaacacgg 1694281 aatcgttgat ggggcacctg tacgaatttg gaacagccgg ggagaatgcg agctgaccgc 1694341 tgcagttgga gaacaagtgc tgccaggtgt cgttgtcagc caaggattat gggcggatga 1694401 acaaggaaaa aaacagcttg taaacgcgct aaccccagat cgcttgtccg atatgggcgg 1694461 cggcgccacc tttttttcag gccgtgtaca gattgaaaag gtttgaaaaa taatgaaacc 1694521 cggagtatgc caagcccgta taacataaca tcgacataat ggaggcatac acatggacgt 1694581 ttttttagga attggtattg ctttggctgg atattttatc ggtgaaggct taaagcagag 1694641 gaaccaaacc aaaggtaatg aacaaaatga tatcttccta ataaaagaac gggatattta 1694701 cttttacatt ggactttttt taggaataac aacgactgaa gcaaaacagt tagctggaga 1694761 catggcagac ctgccttaca tcgaaataaa cggaaaaaaa tatgtccaga aacatatgtt 1694821 aaaagattgg acattcacat tagttgaaaa acatcagggt gaataaaaca aatctgagga 1694881 gagcgagatt cattgtcacg ctctcctctg tttagctgta tggatcctgc caccaaaact 1694941 ttgtgctata agcgctgata aaacgataaa ccaccatcta tgttctttcc tcaaacaact 1695001 caagatgccc gttccacaac aatagttttt atattccttt gatgacgtga tgttcttgat 1695061 gaacgtatgt atcgtaaaac acttagaaaa cctattcggt ttgaatgtgt gctctcatta 1695121 tgcccccata ctgcgccttt atccgcggag gattttttta aaaaaatatg aaacctaaag 1695181 cttttagatc ctgaattttt attgaacctc catatttctc cgattggtaa aaattagcct 1695241 atacaccgga agctgtacgt ttataaagga tcagagaatc ccataaccag taaatcactg 1695301 cagccgcaat acttaacata taataaaagt acgattgcaa tgtccatgct attgacgcag 1695361 gttcattgat aacaaaaaac aggaaagctg cgataaaagc aaccacactg taaatcaata 1695421 ggtacatgac attgaaagtt ctcgcttttt tctgcaactt catttggagc ggaacagcaa 1695481 aaaggccata caccacaaaa ccgtataata aagcaattgc tgccgtaaac aatgcaatta 1695541 tcatatcgcc atacataacg aaagaataaa accctaataa caaaccaaat gtaaggctgg 1695601 atagccctaa tgtcattaaa taatatgatg cgattttttt cattttttca ccccccttgt 1695661 ttgatttatt cacagtgctg ttagtataaa ttcacaacct ttgtatttct tttatcgaga 1695721 tgtcttccct aacgtgctat acgcaatgcg ctaataaaag gtttcaaaaa tgacgttctt 1695781 ttattagata atacgctggc tgaaaacgcc tctcctgatt ggccaaagcg cgaatgaaaa 1695841 aagtgcatga atacctgccc aacagacaga ataagaagag ttgatatttc aacacttttc 1695901 gtaaaggggt gaaaccaatg agtaagaaag gtattcaaaa ttcaagtatt gaacaaataa 1695961 gaaatgacca tgagactgaa acagctttta aagcagatga tcctaaaaaa cacggttccg 1696021 atcctaaaag aacgaaataa gttcttaccc ccactaaaat atcaataatc tggaggaagt 1696081 aaagtgactc aaaaaaacgg tgcagacaga cctgatgatt ataaaagatt ttcttcatta 1696141 gacaaggaat atgattttca gcaatctata cgcagcaata ctgagacaga aagtgtaaac 1696201 actgaaacac aaactcataa caaagaaaac aaaaatgaca caacagatgt tgccgggaaa 1696261 tactttgagc cctcagatta taaaggaagc acgcaattag aaaaaggatt ggctgaaact 1696321 catgaacagg tcagcgatga ctattttgaa gggacaatcg atcaaaattt ggactagcca 1696381 tacaaacgga actaacttaa aagaagtcag ttaactctgt ttttagaaac aaccacagta 1696441 aaagtagcca acccccaccg aataagatgg gggttgcacg taagtagcct gtttaatatt 1696501 taaaacgatt aatgacggtt tgaagttctt ctgccaactg agatagagat tctgcggcat 1696561 aggagatttc ccccattgaa tgaagctgtt cctgtgatga atttgcaacc gcttctgtat 1696621 ttgctgacgt ttcttttgta ccagcagcca atgtatgaac tgtgtgctga atcacttcaa 1696681 cgcctgaagt aagctgttga gttgctgctg caacttcttg tatttgagaa gtgacctgtt 1696741 ccaccaggtt cagtatttca ttgaaatttc ctgttgtctc ttgagaaaga acaatacctg 1696801 agctcacatt ttcttgaaca actttaatat tatttaccgt ttctatcgat tcgttttgga 1696861 tggtcgctac caccgattgg atgtggtttg cagatttatt tgtttcatcc gccaacttcc 1696921 gaacttcttc tgccaccaca gcaaatcctt ttccttgctc tccggctctg gccgcctcga 1696981 tcgctgcatt tagtgccaac aaatttgtct gctctgaaat cgtcgtgata agcgaagaga 1697041 tatcgctgat ttctgctgtg ctcgctacca atgtttgcaa tccattgccg gctgaatcta 1697101 cagatttatc aatgaatttc atctggtcta acatcttgtt gacggactta gagcctattt 1697161 cagccttgtc tctcatcgaa gaagaaagat ccgctatgtt ccctgtattt gaagcgactg 1697221 atgatatact gtctaataat tcagtgatgg attctgcgct cttttctgtc attgagcttt 1697281 gcttcacatt gctgtcggca gccatctgca tggctcgtga aatatgttca gatgttgatt 1697341 tcgattcttc cgcgcttgcc gataattctt cagaggaagc ggcgacttgt tcagatgagc 1697401 tgctgatctg cttcacaatt tgagttaatg aatgagtaaa agaattaaaa gattgggcaa 1697461 gctggccaaa ttcatcttta tttttcacaa tgactttttt ggttaaatca gcctcgccgt 1697521 gtgcaatttc ctccagctgc ttatttatgc ttcttagtgg caccataatg gactttaaca 1697581 gcattatgct tagaacaatg cctaatatta ctgatatccc tgtgacaatg ataatgagcg 1697641 attgactcat tttcccattg ccctgtattt catcctttag atcctctacc tcttgatcca 1697701 ggcgatcaga cagcttattg acagccggag ctacgccttc ttttcttatt gttctttctt 1697761 ctccaaaatg gatggtttct gcttttttag gatttgaaga gtaggctgtt actacttgct 1697821 gattcaaagc tctatactga gtaaaacttg tcttaatgtc ttcaatattg gattgatact 1697881 tctcttcatc aatcaagtca ttaacccggt caaggctctt taagacatcg tctgcttttc 1697941 ccttcatacc ctcgtcgtat tctttgtctc tggtaatcaa gaagcctctt tcatcatttg 1698001 ataacccggt caattcatat tggatgtgtt ttatctcttt ttggaattcc attttgtctt 1698061 taagttcttc attctttttc acagtagaag aaatcataaa tactgaggag cctccaattc 1698121 caataattga aacaactaat attgatataa tccccagcaa ttttgttttc actttcatgt 1698181 gtcgttttcc ctttccgcac aatgtaatgg ctgaaataaa atatgttcaa gcgcgtttga 1698241 atccaattcg cttacgctca tgtccataat atcgacacgt gttatcaagt tttatagtga 1698301 tattcttata tgaataagca aattctttac gtctctgaac ttacagaaaa accttaagta 1698361 aaatttgcag tcttttgcgg tatgtaagtc actcttattc gtttttctaa aaaaggcttt 1698421 tcccacctca aattggctga accggctgtt ttctcgaaaa tataatacaa tacgcagcat 1698481 aatatgaagg agcgaaactt aaatggggat catcaatggt aaagaattca ttgaccgatt 1698541 gaataaacta gaaaacgaaa tatggtatga tggcgaaaaa ataaagggta acatttctga 1698601 gcatcctgca tttaaaggaa taatcaaaac aaaaagctca ctttatgaat tgcaaacaaa 1698661 ggatgagtta atacatgaaa tgacttattg ccttcctgga gatcataatc gaatcggcct 1698721 ttcctatctc cagcctaaaa caaaaaatga tttgaaaaaa agaaggacca tgattgaaca 1698781 ttgggctaga catactcatg gaatgatggg gagaagtccg gattacatga atacggttat 1698841 gatgagcttt gcttcgtcag cggagcttct aaaagataaa gagaattgct ttcctgaaca 1698901 tatactagat atgtatgaac aagctgctaa gcatgacctt tcctttaccc atacattcat 1698961 tactccgcaa gtgaaccggt cacagtccta ttttgggcta agtgaaaaac cgatatctgc 1699021 taaagtcatt gatagaaccg aaaaaggttt aatgattcat ggcgcacgac tgcttgccac 1699081 acaaggcggg ttgaccgatg aaatcttggt tttttcagcg cctaaatttt tctttgaaac 1699141 agatgaagct tatgcttttt caatcccttc taatacaaaa ggcgtaaaat tcatcacaag 1699201 agaatcattt gtattaagcg actcttcctt taatcatccc ttaagctcaa ggtatgaaga 1699261 aatggattca attgtggttt ttgatcatgt gttagtgccg tggaatcgtg tgttttttta 1699321 cgataatgtg gaagcagcta aagattttat gacaaaaagc tcttttcatg cctttacctt 1699381 tcaccaggtt gtcattaggc aaatgataaa aattgaattt ctattaggtg ttgcacagct 1699441 tcttgtcgac accattaatg tttccgaata tcagcacatc caagaaaagc tctcagaaat 1699501 cattgtggga ttggaaacaa tcaaagccct cattgacaaa tcggaaaatg atgctcagtt 1699561 agatgaattc ggctatatgc gcccctgttt aattcctctt caagtcatca gtacgatcat 1699621 tcctaagcta tatcctcgat ttactgaaat catacaatta attggagcta gcggaatggt 1699681 gacactgcct accgaaaatg catttgactc agagatacgg gaagatcttg accaatatct 1699741 tcaagcaacc aatacaaatg ctgaagaacg tgtgaaaatt ttccgtttgg catgggattt 1699801 aacaatgagt tcattcggaa ctagacaaac tcactacgaa agatattttt tcggagatcc 1699861 tattcggatt tcaagcaggc tgtataccag ttatccaaag caggagcagt tgaacatgat 1699921 taaaacattt ttacatgcag atacagaaca ttgaaaaaac agcgggaaaa gatccgctgt 1699981 ttcgtatttt ttattcagga aactgaacat ggcccggtac tgtataggct ttggacgttc 1700041 cgctttcagg cagctttgga atggtgtctt tcacaacttt tccgcggatg tcagtcattc 1700101 tgactttgag agagccagta cctaaattcg tactcacaaa atggttatag tccattttct 1700161 ccatgttgat ccacttacca tccttttcat attccatttt cataacagga tacttgtgat 1700221 ttctgacttg gattgctgcc caccacctgc tgctgccttc tttgatccgg tacgtgaaat 1700281 tgccggtgat tggggctttg acaacacgcc atttaatatt gatttttccg tctttcatat 1700341 tgccgatttt acggaaggca ttaggtgaca gatcaagagc tccccgagcg ccttcgggat 1700401 aaagatcagt aacatatacg gttgttttcc cttttggccc ttcaacttcc aaataagagc 1700461 cggcaagtgc cgcttttact cctccgtaat tgagatccgc cggatttatt gcagtaatct 1700521 ccatatcgga aggaatggga tccagcagga aagctcctcc tgaatagcct gaccctgtat 1700581 acgttgcata accttcatgc aggtcgtcat atgctgccga agcttgcggg gaaaaacaga 1700641 agatcgtcaa caaaaccata ccaacaaatg cactcatgat ctttttcata tttggtcctc 1700701 ctcaaaccag acttcaaatg agaatcatta tcattataag actcaatcca tctggtttga 1700761 aagaggaaat agattcatag ttgattttaa ggcaaattca ctatcattca tatatcaaat 1700821 gtaggtactt atgaaaaagc caatacaaat gaacgaatgt gcacttcagc cgaatgtctt 1700881 atttttccct ctcaaaattc gcatttcaat aacgaaatga aacaggctgt tggcctgata 1700941 acagctatac aggaaaagct atttttcccc gctcagtttc aacttagctg tcatcatgat 1701001 gccaaagatc agcacaatcg gaacccaaat aatgaagtga taaaaatcag gctcagccag 1701061 agcaacaata atagccccta cacaatacaa aataatagcc agtgctctta acacagtatc 1701121 tcttaagaaa gtcttctttt gcttcttaaa aaacaaacgg ccggatatat cctctaaaag 1701181 agaagccaaa gtgccggtca acacagttga agaaatacct gcaatcccca gtttttttgc 1701241 tgctgtagtt tgaatcccca tagaaatgct catgagtata attagaatgt gcacaggaac 1701301 aaatgcccgg taaaaagaaa gacaagcaaa gacaaacaaa atgaatgctt caagtgcgag 1701361 ggcttttgtc acagcagaag gccaaagggt attttccgcc tttccgacca tcaatgtagc 1701421 aatgatcacg ccgcatataa atccgattag cgcagtcaag gaattaaaaa cagtgacctg 1701481 aatggatttg ccgatagcta accccaataa tacaatgttt ccagtcatat tagctgtgaa 1701541 cacatgtccc aggcttaaat acccgattac atccacgatt ccagctgtta aacataaaag 1701601 tgatagcaag gtgtttcgat aagctgctgc agtcaacggt gtatcaatcc tttcttctat 1701661 ttcaattgtt agtatgtctt ttggcgcaat ctctattttt taagtaaccc aacattaatt 1701721 aggaagatag aacctattat tcctttccat taactgtaat aataatcccc gcaaggaaat 1701781 gattaaaatt gaaaggaagc atattgtgat gaaacgactt tgtttatggt tcaccgtctt 1701841 tagcttgttt ttggttctct tgcctggaaa agcattaggt gcagtcgatt ttccgaatac 1701901 ctcaacaaat ggccttttag gttttgccgg aaatgccaaa aatgaaaaag gcatctctaa 1701961 aacgggcaca acgggtggaa aaaacgggca gattgtttac attcaaagcg taaatgattt 1702021 aaaaacccat ctaggaggat ccactccgaa aattttagtg cttcaaaatg atctttccgc 1702081 atctgcgaaa acaacagtta ccattggctc aaataaaaca ctcgtgggct cttacgcgaa 1702141 aaaaacgctg aaaaatattt atttaacaac ttcatcagct tttggaaatg tcatttttca 1702201 aaatttaacg tttgaacaca gtccgcagat taacggaaat aatgatatcc agctttattt 1702261 agattccggt atgaactatt ggattgatca cgtcacattc tcaggtcata gctataatgc 1702321 aagcggaagc gatttggaca aactcgtgta tatcggaaaa tccgcagatt atatcacgat 1702381 cagcaactca aaatttgcga atcataaata cggtttgatt ttaggatacc cggatgattc 1702441 tcagcatcaa tatgacggct acccccacat gacaatcgcc aataattatt ttgagaactt 1702501 gtatgttaga ggcccaggtc tgatgagata cggttacttt catgttaaaa acaattacag 1702561 caataatttt aaccaggcga ttacaattgc tacaaaagca aaaatatatt ccgaatataa 1702621 ttactttggg aaaggcagtg aaaaaggcgg catccttgac gacaagggca ctggttattt 1702681 caaagacata ggcagctatc catcactcaa caagcaaacc tctccgctga cttcttggaa 1702741 tcctgggtca aactatagct atcgtgtcca aacgccggaa tatacaaaag aatttgtcac 1702801 gaaatatgcc ggatcacaaa gtacaactct ggtatttggc tactgatata aaagaggccc 1702861 tgcgttaaaa acgctgtgcc tctttttata ctataggcta tttttaagcg atccttgtaa 1702921 ttccatcaag atccagcgtc ggtcaaacta aaaagcatat gttcttttcc acaataactt 1702981 cttaactggc tttcttatta taccagttta tcgcaagtga aaagaaatca ttgttctgaa 1703041 cctgtattaa atgaacgatc gtcccacaaa ctacttaaaa acccctaaaa aggatgatgg 1703101 atatgtgcgg caggtttact ttgtactctg catttgatga tattattgac cagtttgaca 1703161 tcgatcaatt ttttcctaaa ggtgaatacc agccaagcta taatgtcgca ccatcacaaa 1703221 acatccttgc aatcatcaat gatggatcaa ataatcgctt aggcaagctt agatggggac 1703281 ttattccacc ttgggcaaaa gatgaaaaga tcggttataa aatgatcaat gctcgagccg 1703341 aaacaattac cgagaaaccg gcctttcgaa gaccgcttgt cagcaaacgc tgcatcatac 1703401 cagcagacag tttttatgaa tggaaacggc ttgattccaa aaccaaaatc ccaatgcgga 1703461 tcaaattgaa atcatctgct ctttttgcgt ttgctggctt atatgaaaag tggagcacac 1703521 atcaaggata ccctctttat acctgcacca tcataacaac tgagcctaat gagttcatga 1703581 aagatataca cgaccgaatg ccggttatat tggcccatga tcatgaaaag gagtggctta 1703641 accccaaaaa tacaagccct gattatctgc aaagtttgct gctgccttat gatgctgatg 1703701 acatggaagc ataccaggtt tcatcattag taaattcacc caaaaataat tcagctgagc 1703761 ttcttgatgc agaaaatcat atgtagtgat tgaaaaaatt ctctagcaag aacttgtcaa 1703821 atagctttgt tccttaggtg ccaatccctc tagtaattat gaatatttag tacatagatc 1703881 aattagttat ctttagcatc agtttgaaat aattttatta tgtaaactta aataagcaat 1703941 gttattcctt tcatataaaa tagtttacat ttttataaaa tcgcttcact tttctatttt 1704001 gtcagcaaaa aaactgaacc acattaaact tatgaaacct gccgcacctg tggattgcaa 1704061 atatgatata agcccataga ggtaaatcca tacactttcc ctcctaagaa ttaaatgaaa 1704121 tttctttcat cttacatgaa ggtcttcttt cttttgttta tccagtgtaa tacttaataa 1704181 tatgttgatg aatgcagctg gaaaatatat aaatcccact ccaagaatgc ctagtatcgt 1704241 acttaaactt actatgtaat tctttgtcat cgtttgactg tcaatcaata ttagaagtga 1704301 aatcaatcca gctaaaacac ctataaacca agcatcgcca acagcataag aatcatccag 1704361 catccctaac catcgcccca atatagagct cccaatggca gtcaaactgg ataaaaatat 1704421 gagtgctttc atttcttctc ctcctttaaa gccaatcaaa ctggtagaaa tcggccattg 1704481 aatccccatt atcgaatggt taccatttca tttccacatt aacattttaa agctcattac 1704541 aatacgattc aagcagaaaa accctacata acgtatatat agggatttaa taaaacacag 1704601 gccaaaattc agctctatct actttaaaaa gatatgaagg gcagctgtgt gatctgttac 1704661 gtctttacgt accgggatat ttcacaacag gcactttctt cttgcgcaga gaatcaagca 1704721 tgactgatcc agcattcaag ttgctttgta ctaattcttt aggcgtcaat gccatccact 1704781 gattgagtga cacatctgca tagcggttac ttttgaacat ttctaaaaac cataatgttt 1704841 ctgtaccagt gttttgtata tagtgtccgg cattagaagg cacgtatcca acgtcgcctg 1704901 ctctataatc aaatgtgcgg gcagtcccat ttccgataaa taccgtcatt cgtccctgtc 1704961 ctgttagata atattgccac tcatcgctat tgggatgcca atgaagctct ctcatcgcgc 1705021 caggctcaat ctgaacaagt gcagcggcta tcgtttttga aattgggaag ttagaagaat 1705081 ccacaattcg tacactcccc cctggcattt gaattggggg ttgatttaac agctcgtgtt 1705141 taaaggtcat ggggactttt ccatatggtg actgaatgtc ttcactggcg actgatcccg 1705201 gcacattccc ttggtagata tagacttgct cagacggaag agagttgaaa gcattctccg 1705261 ggacaccgaa atttgcagac agaacatctt ttggtgtgtg tgcaagccaa tctgaaatgg 1705321 ttaacgttga aaactcagaa aagttcccat catcgaaaac gagcagaaac tcgcagtgtt 1705381 ccaatccctg tatggaatgc ggaattcctg ccgggaagta ccaaaggtcg ccgggaccaa 1705441 catcagcaat gaaatttcgt ccgtcttggt caacagcggt gatacgtgcc cgtcccaaaa 1705501 gcatataagc ccactccgct tgcttatgcc aatgaagctc gcggacgcct cccgcagtta 1705561 agctcatgtt tacacctgca atcgcagtcg aaatcggaag ctgtcttacg gtgatttctc 1705621 ttgaccagcc gccgtgatct aatttcatgg gagcgtctga gaatgaaaat ctcaagttag 1705681 gaatcatacc ctcatctgta acaggcggaa caaatatatt cggattttga atatcccgta 1705741 ttatatttcg cgggcctgta tcaatagctc cagctccatc acttcgaata ggctgcggca 1705801 cgtttctgtc ttcatgattg attggttgtt gttccaacag catgcacctc gttttagaaa 1705861 tgaacaagat tttatttcag cctatgcaga atcttagatt gctgtgccta ggaatccgca 1705921 aataaaaaag tgaccaccaa tgtgatcaca aatacatcaa ataaactatt ttttatacca 1705981 tggcttctta tgtaatttga ttgcttctgt ctgttttttc tggcctgtcc tccactccac 1706041 ttttactaat acatcatgac ctatcacttc atcttcaggc atataatcaa aggtggaaat 1706101 atggtcctcc atgcgtcccc cacccggcat ttcatcacct gtgtactccg ataagtcgta 1706161 ctcatctacg ttatcatctt gatacttttc gccatctaca tacagagtaa ttctttcaac 1706221 aacagtccac ttttcttcct tcttactccc ctgccaatat agatttagaa aataattggg 1706281 tccaattgaa gttttgtctg atttttcaag gttagacatc cacagtccgc ttttcccgct 1706341 gccctcatat ttcactttgt tccctgacac cattacaaat aatgtgatga tgcagatgat 1706401 caagaatcca gcaatgatca atagccattt cttaatattg ttcttttttc tcatgttttt 1706461 cctcactttc ctaacttttt agtaggaaaa tacgatcaaa atgttaccga aaagaaaata 1706521 agaaagggct aatgatctaa cagatgactg tctaaacttt tgacttaaat taaagtgctt 1706581 tctaaagaca agattaaaac gtataacagc tcttaaatgc attttttgtt tcattgagtc 1706641 aagaacctta aaatggcttt ttattattaa aaatcaagct agtgtattaa gtaacttttc 1706701 aaatttattt atactcatga tctcgtgagt cacaaatctc ccatcaaaaa aaacgctaaa 1706761 agttgtccaa atagctggtg acttttgtgc ctcttctttc gatgataact gaattgactg 1706821 aaattgaacc cctttctttt cagtcaattc ccgcaaatca tttatcatgc ccactgcaaa 1706881 cggacactga gctgtatagt atatcgtaat ccccttttca ttgatagaat cacttttcac 1706941 ctggctctta aatgcaggag aatctgcaag gccattccaa gtcaaagcca ttaattgaaa 1707001 ataaggggca gcttcatctt gtagagtaaa ccccatatgc tcaaagaaat gcttatcact 1707061 taaatagggc agttttttct tgcctgcgat atggataatg ccatccatgc cgcacgcttt 1707121 cgcatctgct atacatttgt ccaacaatcg tttcgcatga ccgttatttt tatatctgcc 1707181 agacacccac agacaattaa tgtacataaa attaggcgca ttgataggca cccatgcctc 1707241 attcgcaggt aggtattcaa taaagacttt tgcccgttca tgtaagcgat agaacaccaa 1707301 tccttcatcc attcgagctt tgagccatct cttcttttca ttaactgcat gctcatattg 1707361 tttcgtgctt aatgcacagc aaatatgatt gtcttcaata ttgtcctttg tgatttcaat 1707421 gtagcacatc tcctctttcc cccctttaac ataattacat ggaattcaac ttcacacttt 1707481 acatgcctaa tagaataaat acccgttcca acttaaatac tttttctttt ccattttgcc 1707541 aattaactgt aaaacccttc ttttattcag atattatctt gattcctata tcacccattt 1707601 caaatccaaa gtgtgttcat ctttgaggat tagatgcact gcttatgcta taaatacagt 1707661 acacgaagtt ttttatttga agtaatattt gttacgggac agcaatagta aataagtgat 1707721 aaaaggggaa ttaaacttgg tggaaaaatg ttattcttgt ttaatttgcg gatacaaagg 1707781 attaattcaa aatcctttgt ataaaggcga gtatcaaaaa acgtttgaca tttgtccatg 1707841 ttgcggtttt gaatttggct acagtgagga tcatgatgtg aggttaggtt ttattgtaac 1707901 tcctgatcat ttaattgagg ctgcatttca attgtatcgc aaacaatggc ttgagagcgg 1707961 gatggtaatt gctcatccgg aagatattcc agaagaattg aaaaatggca attgcttaaa 1708021 atttgaagtt ttgttgaaac aattgaaaaa actaaatctt gacatagaaa attttgaaat 1708081 tagcggtttt taatgatgaa acaggttgca cttgtttagg tttcactgtc attatcagta 1708141 aaatgttaag ttgaaatgcg caatcagtca caaagtctct attcgtattc aataaagact 1708201 ttgtgatcat cgacaaacat ttcactccca tcggataaag tatccaaaag gcctcctctg 1708261 gttcttctct atagtcatta atcacagtca ctttgacatt tgactcagct atgattggtt 1708321 ttccaacaat ttttcgtttt ttcctcaggc aaagtaagag atcgaatcat caaagccatt 1708381 ccatctttac tgtctaatta acgccatctt cagtgaattt aaaggtctgt tttaaattgc 1708441 gtccttcttg ccccttctgt gtccaaatta taacaacctc taattcagag gccttatctg 1708501 ccagcataaa atgattgaac ttcagcggtg agccatcatt taaactttca gctaacattt 1708561 tagaatcttc ttttggtttg acacaatttt catcgggaca tccaaaaagc gaaaaccttg 1708621 tgattgaatt agggtcattt ctatacaatt gcacatccac tgtagctgct ttttccccta 1708681 tatttttgac ttccaaggaa tatacttgat attctccttt atgaggtctc gtaaattcct 1708741 ttacattttt tgcttcactt acttttactg accactggtc tgttttttgt gtaataggca 1708801 acaccgtaaa agtcagggca tgcgcttttg attggcaaaa cgtaaatcca actgctgtaa 1708861 aaacaattac agaaaataat acccttttca cttcatttat ccctccttcc tttcactggc 1708921 cgctccttaa agaattgatt ttgagcaatc tacaagctct cttaaccaaa accttacctg 1708981 aggttttgtc tttactgctc tgcatttatt tctttcggta tccgagaagg agctttgggg 1709041 atttttctca atctgctgtt aatcacatca gaagagtata gcgtaataat catacttccc 1709101 ccataccttt ttgcccgaat taagattggt tggttatatt ggttttgaaa gcgaaagtca 1709161 ggacctcccc agcttaccgt cgcatcccgt ccgggcggta catatggtac acttctagta 1709221 tgagaatagc gctgaacgat ctgcagtcct gcacgatcta ctgcattaaa tagagttgag 1709281 gacacctgac aaattcctcc tcctacacct tcagacaact ccccttttac aataatgggt 1709341 gcacttttat atcctttgtt ccgagttctc attcccacaa cttggttaaa cgaaaacgtc 1709401 tcattaggga aaacaacgtg attgtcgatt gcttttgcag aaagagaaat attgtgtgaa 1709461 cggcttttat tgcttgagtt aaaatacgtc acgtactgac caagctgctg cgtactgatg 1709521 tgagctagca gctcgctgtc aactttcgga taaatgttca tttccggcac ttctatcttg 1709581 gagggacctt gcccataaaa atacgcataa aacttttcca taaacgcctg ttgatacagt 1709641 ttgtagccaa ccctgcccgg gacgatgctt ccatgatcgt taaggacagc atttatcggc 1709701 tcacggtaca ctttctgatc aagctgtttg atgaatttac tgtatttttc atagtcaacc 1709761 attggagtgc cgggaagagg cattgtaaag tcttcacggt taacagtggc aatcgtccgt 1709821 ccttgctgtg tgaccgttaa actgtcctgc ggctcactcg gctgagccaa taaaaaaaga 1709881 ccagtgatca aaatttgtat cataagtcgg tttacctccc aatcattagt atgaacagcc 1709941 gcttatcctt tgatgtattt cttcccatcg tttgtttgaa tctttagacg ttgataaaaa 1710001 ccttcataaa agagcttagc tttatgttca caccgatccc tgagctcact gaggcacacg 1710061 gttcattcag tcggcaagtt tgaagtagtt cagcatctcc cagtgatgag ggatgctttt 1710121 ttgtcttgtc aaaaatgaaa agggtctcct ataacaacaa aaaatcaatc catttcaata 1710181 tttttttatt gagaaacgat aaattttttg ttacattcaa ttagacaaca aataaatgag 1710241 gtgcttgtta tgaatcgaat gtcgacaatt tttttaaaga tagctttggt tcttattgga 1710301 attccaattc ttgctttatg cattttttta gtgcctaagg tagccaacta ttcagcagaa 1710361 ttatttccaa atatcgctta tataaaatat ctcgttttca tctatttgta tgtaacggcg 1710421 ataccttttt actttgctct ttatcaagcg ttcaaacttt taagctatat tgacaaaaac 1710481 aaagctttct cgggtttgtc tgtaagagct ttgaagaata taaaatattg cgcagtcact 1710541 atcagtatct tttacgcagc aggcatgcct gtcttttatc tgatggccga gatagacgac 1710601 gccccgggta tcattgtgat cggattggtt attatttttg cttcaatggt gattgcggtc 1710661 tttgctgctg ttcttcaaaa actgttaaaa gaagcgattg atataaaatc agaaaatgac 1710721 ttaacggtct gaggtgatga catggcgatt attatcaaca ttgatgtgat gcttgctaag 1710781 aggaaaatga gcgtaacaga gctttcagag agagttggca tcaccatggc taatctttcg 1710841 atattaaaaa acggaaaagc aaaggctatt cgattatcaa ctttagaagc gatttgcaag 1710901 gctttagaat gtcagcccgg ggatatattg gaataccgaa gtgatgaaga cacaggattc 1710961 gtaaagaaaa aatatgaagg atcaacagaa aaataaagtg attggcggtg agcttatgga 1711021 cataaactta tatccatcta gctgctatac taagcgtccc tttcatacac gaagaacaca 1711081 actatggagg aggcatacat catgagagcc ataaaacaaa tcgtccattt tggctgggaa 1711141 caagcccttt catgtttgtt tcctgccgtt atttttgcct ctttggctat tacgcaaatc 1711201 atcccactgc ccttcttgcc gcggtatgac tggctgctca ttatctgcgt tctcatgcaa 1711261 ttgtggatgg tgcgttccgg tcttgagaca cgggatgaat taaaagtgat cacattattc 1711321 caccttattg ggcttgctct ggaacttttt aaagtccata tgggctcctg gtcttatcca 1711381 gaagaaggat actccaaaat atttggagta cctttgtata gcggctttat gtacgcaagt 1711441 gtagccagtt atttgtgcca ggcatggaga aggcttaagg ttgaactggt taagtggccg 1711501 tctttttttg cagttgttcc gcttgccgca gcgatttatt tgaatttttt cacccaccat 1711561 ttttctatag acattcgatg gtggttatca gggcttgtca tcattgtctt ttggcaaaca 1711621 tgggttacat acgaggtgaa tggagctcgt taccgtatgc cgctcgcact ttcttttata 1711681 ctcatcggat tttttatatg gatagcggaa aatatcgcta cgttttttgg agcttggaaa 1711741 tatccaaacc aaatcgatac atggagtctc gtacaccttg gaaaggtaag ttcatggctc 1711801 ttgctagtga ttgttagctt tcttatagta gcatcattaa aacaagttaa ggagcagagt 1711861 cccacaaagg cagagatgga tgaatctttt tcttagcata cgcatacaag ctcccaaata 1711921 gagtgaaaag caacgttcaa atggttgctt ttttctttta tgtaactctg ccggtgagta 1711981 ttcatcttct tcaaatttca tcgcaacacg ataactgatt cagattacaa ctgctttcaa 1712041 cactttgaca aactcatgcg ccgccggcgt tatctcttca aatgaatgtg cgatgacgcc 1712101 aatatcgcgt gtgaccctag gaaagatgtc ctttttaatc aattgatgcg ggacggatga 1712161 aagtgtaaag tttgaaatga tgccgatacc caagttattt ttgaccatat taatcaaggt 1712221 ttcggcattt tgcacagtta agttttcctt taattcgatg ttgtattgcg aaaatgcgtt 1712281 tgacatcgcg atttcatgac cgcctttaca aaaaatgagg tcatcttgat atgtttcaag 1712341 gtcgacatgc ttttcaagtt ttaattcgtc acgctgcggc gggatgacgg ccaccatata 1712401 gtcgttacac aatagctgat tttcaaacgg ttcaaatgga gatgctgcga tcccgatatc 1712461 aaccgtccga tcttcaaccc atccttttat ttggtcagag gttccttcga tcaattctat 1712521 gcggatcagc gggtagtttg atctgaatgc cgcaatcgcc tgtggcatga tatttgttga 1712581 aactgcagga aatgaaccaa ttttcacctt cccgtttaac agcttgtttt cccggttggc 1712641 tacttgatat attttgcttt caattccctt catttgcctc gccagcagca atatttcttt 1712701 tccgatgtca gtcagcatta aaccatgatg tttatccctg atcaataatt tgagctgcag 1712761 tgagctctcc aggtttttta tcgctttact taccgccggc tgagagatga acaattcttt 1712821 tgccgcttct gtaatattta atttctcccc aacttttaca aatatgtgaa gatggttcat 1712881 gttcataacc atttggttat acccccaata ataaaaatgt atttcagtta tacataaatg 1712941 taacatatga tagaaaccag cacgatattt taacaagaaa ggcggcttca ttatggtaaa 1713001 agttatgctg ggaatcatat ctgtcacact tatttggggt tatacttggg ttgcgatgaa 1713061 agtaggaatt catgacatcc ccccgctttt attttcgggt ttgcgcctgt tcatcggagc 1713121 agttccttta tttctcattc tcttcatcca aagaaaaaag ctttcaattc aaaaagaaca 1713181 tctcaaaagc tatatcatca tgagcctgtt gatggggctg ggctatatgg ggattttgac 1713241 gtatggaatg cagtttgtcg attcagggaa aacctctgtt ttggtatata caatgcctat 1713301 atttgttacg gtgatcagcc atttttcatt aaacgagaaa atgaatgtgt ataaaacgat 1713361 gggactggtc tgcggcctct tcggactgtt atttatattt ggaaaggaaa tgctcaatat 1713421 cgatcaaagc gctttatttg gggagctgtg cgtacttgtg gcagcgctta gctggggaat 1713481 cgcgaatgtg ttcagcaagc tacaattcaa gcatatcgat attattcaca tgaatgcctg 1713541 gcaccttatg atgggagccg tcatgttatt ggtgttttcc tttatatttg aggcggtccc 1713601 ttcagccgag tggacatatc aggcggtgtg gtcattgctg tttaatggct tgctttccac 1713661 cggctttacc tttgtcgtat ggttttgggt gctcaatcaa atccaagcgt caaaagcatc 1713721 catggcatta atgtttgttc ccgtattggc cctattcttt ggatggctgc aattgcacga 1713781 acagatcacc atcaatatta tcctcggcgc actgctgata tgctgcggga tttttatgaa 1713841 tacatttaca ttttcacgac ggaaagtgtg aatgatatac atttcccctg tcatttgggc 1713901 ttcatgtgac aggagaagac tattacgaga aagtcttcta gaatcctgac gacagcctat 1713961 taaacaatga aaaaagctaa tgtctgcatg tagacattag cttggctggc gtttaggctg 1714021 gtgagaatcc agatactttt ttattaccat tctggctgat caaactgaaa accgtataga 1714081 ccttttactt taacatctcc gcaatctgga tcttttgtca aaatcaaata atgagtctta 1714141 taaggcatcg tctcaactcg atcagttgca ctaaaatcaa aatgatcccc cgagaagttt 1714201 ttttcactaa cggttatttc atatcctgac aaagtcattc gcatgattct tgcgttaatt 1714261 gtacatcctt cagtatcgaa aatggtgaat ctgtacccaa agtgagatgt ccaatggttt 1714321 gaatttaggt catcagactt cataaaccat ttttcattct ctgtcattgt aaaactcact 1714381 ttctcctcat ctttcacgat aacggccgaa gcttccccta catggatagt caaagccaaa 1714441 agaaatgtaa aagctaacat caacatcttt ttcaaaagag ttcctcccga tatcttttac 1714501 ttcaatatat tggaagggtc ttttctgatc aagacagtct tctccaaatg aatctttagc 1714561 accatgaaat gagccttaat aagaacagtt ttaacccaaa tcaacctcta ttcgaaataa 1714621 ggcttaccaa tctatattct ttttaaaagt ttctgcattt ctttatttag ctcctagaca 1714681 catataaaaa atgctcctat aagttcagga gcactacaaa aaactgctaa agtgttttct 1714741 atcgatttat tgtattcatt agctcaaaga aatattcagg cttttgagtc ttatttagct 1714801 tataccatga acgcaatgta tctggtgcaa atacatctaa ttttttcaat acttctaccg 1714861 caaattccag aggagcaatt cctgatgcag taaccaaatt ttcatcagat actgcaggcc 1714921 ccttttcata gaatgtttct cctttgtaat tagggcagac catattcata tagtcgaggt 1714981 cattgcttgt gtgctttctc gaatttaagt atccttcatt cgcgaggccc aaggttgccc 1715041 cacaaattgc agcaatagtc gtgccgagct ttaaagcgtc gccaactttt ttcaagatcg 1715101 gctgatgaat atcttctccc caagtgtttc ctccgggtaa aatgataaga tcttgactcc 1715161 caagagtaca ttcgtcaaga gaaatatctg gttttatgct taatcctccc aacgtagtta 1715221 tcatttcttt attaacccct actgtaacta cttttaaaga tgctgcatct tgtttaaagt 1715281 atctccctga gtttagttcc gcaattaaat atccatattc ccagtctgac attgtgtgaa 1715341 atacgtagag ataaactttt ctcgtttgca tccaataaca ctccaatcac aattgataaa 1715401 gctttctaat agatgacttt gctgacagtc attgtcagct tttttgttga ttctattctt 1715461 atgcccttgt tctcccaact tataaaaata taagatcaat tgattctatg tttactagcg 1715521 caaaggggtt tgttacacta actgtcatgg gaaacatttc aaaggtaata caaaatcatt 1715581 tgaatgagga ggcctgatga agttgaaaac taaagcgtca ataaaattcg gaatatgtgt 1715641 tgggctttta tgtttaagca ttactggttt cacacctttt ttcaactcaa cacatgccga 1715701 agcaaaatcc atagaagaca caaacatggc aagctgtata acgaataaaa aatttgttca 1715761 acttgagaaa aaatttgatg ccaggcttgg tgtttatgca attgatatag gttcaaacaa 1715821 gacaatcgcc tatcggccga atgaacgatt tgcttacgca tcaacctata aagttctagc 1715881 cgcagctgct gtcctgaaga aaaactcaat tgaaaaactt aatgaagtca tccactacag 1715941 caaggacgat cttgttacat attctccaat cacagagaaa cacctagata caggcatgag 1716001 cctaaaagaa atctcggaag cggctatccg ttacagcgat aataccgctg ggaacatctt 1716061 gttgcaacag cttggcggcc ctaaaggttt tgaaaagtca ctgaaacaga ttggggatca 1716121 tgtaacgaaa gctaaacgat tcgagacgga tctaaactct gcgattcctg gtgatattcg 1716181 tgacaccagc accgcaaaag cactggcaac cgatcttaaa gccttcactt tagataacac 1716241 tctcacgact gacaaacgca tgatcttaac cgattggatg cgaggcaatg ctactggtga 1716301 cgaactgatt cgggcaggcg ctccaatagg atgggaagtc ggcgataaat ccggagccgg 1716361 aagttacggg acacgaaacg acattgctat cgtttggccg ccaaacagag ctcctattgt 1716421 tgtggcaatt ctgtcaaacc gctttacgaa agatgctaat tatgataatg ctcttatcgc 1716481 tgaggctgca aaagtcgtcc ttaacgatct caaataatat gtttagcctt ttgccacaaa 1716541 ggaaaagaca ttactttttt aacttctacc gttcattttt tgatgaacgg ttctttcata 1716601 agacctctag aatcatatat ttaaacacca caaaattaaa cattattata attaacagca 1716661 agttttcatt ttatggaaca agtaaagttt gaatctgaca agaattaaga ctaagcaccc 1716721 taaaatccgt tttcttttct tccaagaata tactccttag tgcaagccat tataaagata 1716781 caagtgaaca tacaatgcag acaactctct taagtctctt attctgtgac caatttgtaa 1716841 tactcatgaa tatccggact cacttccaat atttcgtctc gttcgaagac actaacatat 1716901 caaaccactt gaattaacat aactgaactt gatattggtc actggcagtt tcaatgcaat 1716961 agaacaacat ttgttgtctc agaggttatc tatatgagaa ttcaacaatt tttttataat 1717021 aattcatatt tttgtatcgt tgcacttggt ggatttgact cttttcgtgt atggaaccac 1717081 acttttattt tttcacctct tttgagatca tctgtgttat caatctcact taatcctaca 1717141 attactatgt tatttttaaa cttgttcata agttgtcctt cagaaagatt gtaatcttct 1717201 tttcctggag cttttgtatc ggtaatgaga attgcccttt cattgtcttt aagcacgaca 1717261 tagcctacta ggctctgcat ctttgtttcg tctccgtttt gttcattttt attgcagcct 1717321 gcaaggaaaa taatgagcat aatgagcact atcaagctta ctccgatttt aggcatcttt 1717381 cttcctcctc tttaaactca tctttaaaat aaacaacagg atatcaccca acccatctac 1717441 ttctttttgc aattcataac agcagcatac tcattctcca attcctcaac cttcttttta 1717501 ttctttctca aatatttgca tgtggtagcc ctcgatatta tccgcttact catttttgcg 1717561 ctttcaaata tattattgaa ggccgcttct ttctggattc cagcataaat atacttatcc 1717621 ttactgtcgt ttactatcgc aacttccatt aaaatcgaga tttttacttt ttttatgatc 1717681 cattattcac ttccaaaata acttccaatt acaacataat atatgtataa attgtaaatg 1717741 gagttgatgt aattgaagat taggaaaatc ttattgagtt ctgctttatc ctttggcatg 1717801 ctaatatccg cggttcccgc attggctgct ggcacttcgt ctgaggttgc agtaaaaaat 1717861 gaagaatatg attatgacac tatataccgc attagtcctc tgccaatgga cttccagcca 1717921 acaatagaat acaacggtta tacttatacg cttacacgtc attattttga ttactcaatc 1717981 gggttttaca cggctattta tacaaaagtt gtttaaactt ataaaggagc tttttagctc 1718041 ctttttctct tgttttaagc aaggtatttc tttctatgtg gtcccctatc aaatacaaca 1718101 tcaacattct ccagttctct ttgacacgaa caaaatctaa agtttggttt taaatgctgg 1718161 taataaaaaa ttcactttaa agaagtgccg cccgcaaaat acggcttttg tacactacgc 1718221 caattttata ttgaaaagcc agacctcctc aaagaggttc cagcttttct taatgtgcta 1718281 tcgatcttcg ttagttcaac gggaacttta tcattcggta caaatgcagc ctcccaactt 1718341 ctagttaggg ctgatggcgg aatatctgac ggttctctac acacatcaga cattagaaga 1718401 tttcaatgta gccttctgta ccatgaacgc gaattcgttg cccatctttt atcagcttgg 1718461 cagcattttc aacgccaaca actgcaggta agccatattc acgggctata acagctccat 1718521 gggtcatcag ccccccaact tcggtgacta ggccttttat ggatacaaac aatggtgtcc 1718581 agcttggatc ggtaaaggag gtaactaata tatctccatc ttctaaatcc gcatcttcca 1718641 tgtttaaaat gacacgcgct cgcccctcta taactccgga ggaaacaggt agacctacaa 1718701 tcgctccggc tgggagattt tctcgtttat actcacctgt aacgatttca ccatcagacg 1718761 tgataacacg tggtggagat agtttttcat ataatgtgta ctcgtctttt cgtgtactga 1718821 tgatttgata atccagttta tgtgtgcgca cgacttcgtg aagttcttca aaagtgagat 1718881 agtatatatc ttctttttca tgaataacgc ccgcttctat gagttgttcg gcttctttca 1718941 gtaaagcctg cttataaacg aagtatcgat taaccatgcc gtattttgga tattccctaa 1719001 acccgctgaa attccggatg atatctatcg ctcgttttgt ttctttggct ttttgttcac 1719061 catccggtaa ttgcttcaat cgatctaata actcttgttc tttcttcaaa gcttcctgtc 1719121 gcccttgctc aaatttccga tggccgacat taggctcaaa atttttaata ttattaagaa 1719181 tcattgggac aagtgtagtt ggtttttcgc tccatcgagt tcttgtgata tcaatctctc 1719241 cggtacatcg cattccgtat ttgctgagat aatcatagat cgcgtctcgg gttttgcttc 1719301 cgccatcaaa cttagccagt tcatccaaaa agttatcatc ttttacatgt tgtaagtaat 1719361 caattacctc tggataagga cgaatcacat ctgcgacgtc taatagcgca agacccattt 1719421 ctgaagtaat attatggggt acagattgag aaagcgtatc tgctgcgttt ttttcaccta 1719481 accactcgtt cattttttcg ttaatccata atgaagcatt catagcagtt cgaattagaa 1719541 ccgaactttt tgggttaaat aaaatcttct ttaattcctg aatatcttcc agaataaaac 1719601 gaaataaatc tgatcctgat ttcgtttgga tgttttgttt taactcttct atcgatgttt 1719661 gactgctctc aatcaaatca gacacgattg tcggatcgtt ttcaacttga gccggcatat 1719721 ctgcattgcc tctgctggga tttggtgctg ttttatcatt tggtatcgac tttatgaaat 1719781 ctcgtcgctt tattatggtc ataagtgcgt cttttaagag ctgatcgtgc tgccccatgc 1719841 cttttaagaa aacttctctg ctgtcagggg atgccagatg atgtgtgaca tcaacaaata 1719901 gccttccacc ggctttacgc atgggtgcaa cagtcgtcaa cagaaaaaaa gacaatccca 1719961 gtggttttat gggatccgtc atcatttgtt gatgaccaac agaaatatag acgtgatttt 1720021 cttggtcact cgcttcaggg atggggaata aagtagtgat tggacgactc tgtacaatat 1720081 aaaaagtatc gcgggccaaa caccattcga tatcttgcgg ctggccgaaa tgagcttcga 1720141 tctgtcttcc aatgcgtgcc agctgtaaaa tttgttcatc agtcagtgtt tgagcctttt 1720201 gctgatcaga atcgatctgc tgtgtttctg ttccgccttc ttttcgtccg tagatagcca 1720261 tttttttagt tgctattctc ttatcgatga tttgcccatc ctgtacttta aaacaatcgg 1720321 cagataccaa gccagaaacc agtgcttcac caagtccaaa accggcatcg atggataaca 1720381 cctttcggtt ggaggtaatc ggatcagcgg taaataaaat ccccgaagcc tgagggaaaa 1720441 ccatcctttg aacgataacg gataaataga cttggctgtg gtcaaatcca ttttgcatac 1720501 ggtaaataac cgcgcgatcc gtaaataggg acgcccagca tttactgata tgctgcaaga 1720561 ttgcatcgac gccggtaata tttaaatagg tgtcttgttg accggcaaaa gaagcatgtg 1720621 gtaaatcctc agcagtcgca ctagaacgca cggcataggc atgttcctcg ccaaactggg 1720681 agagatattg agccactgct ttcacaacat cggaaggaat gtctacttcc ataatgattt 1720741 gccgaatctt ccggctgatg ttaccaatct gatctcggtc ctcaactttt agcatggtca 1720801 attgatccaa caacacttgt aacgtttcgt tttgttcgat ggctttttga tatcctactg 1720861 ttgtgacaca aaatccttct ggtacttgta taccttgaat ttttgataat tcccctaaat 1720921 gtaacccttt tcctccaacg agcgaaagct gtgttttttc aatttcatgt aaaccgagaa 1720981 ccaaagaact cattctacat ctccccttca aaaaaaaata ttgacaagag cttcctagca 1721041 ggatataata aaattataag atggatatct ataacttttt aactagaaag cgcacgtagt 1721101 gtgattatat caccgtgtct gtttttgtgc aatataaaaa gaacctggga aatttcacca 1721161 ggttcttttc ttaatttcca tagctagtcg cattaaaaaa cttggtttga gctgattcaa 1721221 tcctctaagg aaatcctaaa gttgggttct ttttgaactt acttgctttg ttcgtagagt 1721281 ccccattcat aaattggact ttttgttctt aacagtccca cctttaacta gtataaagtt 1721341 atgaggatct ggttaactac tagatatttt tattttgaat aaggcttatg tttgataaag 1721401 aagggttatg taaaggtgtc tgttgtgagc aagcgctgac tacaaaaaat tgatagcatt 1721461 ctcatttaaa taccattcta ttaacctata gggaaagttt taaaaccaga tggagaatac 1721521 cctacctcca gcaattccaa ggccgttcac ctagtagaaa acaaccttta accattacta 1721581 acgattttaa taatcattga ttataaaact tctcaaggaa cgatcagcag cccgttagct 1721641 acccctgatt aaggatgatc tgttaccaca ctgttacgtt agaacttcca ctactttgat 1721701 atccttctgt cgccatgact tggtaagccc aattactgcc cagattcatt ccatggctct 1721761 tccatgcgtt cacatgattg ctgaaagtga ttgtagcgtt gcttccggtt ggtctcttcg 1721821 actggcgaac actccagtac tgcgtaaaag tagtgcgatc gccatcaatg gaaggtgcgt 1721881 tataacgtgt agttgtatat atgtcatatg tacccccatc actttttaca gtacctttat 1721941 acgttccagt aggtctataa gtaccccatg aatccactac ataatattct atgagaggtg 1722001 atctcgtcca accatataaa gttaaatatc cattgccatt cggcgcccaa actccggcat 1722061 tatagtttat cgtcctaaat ggcgaacctg tagtccaacc tttaccaaca acaaaatttc 1722121 cggtattaga ccaattaaca ctgtaattcc cgccagaccc attgacagcg tttactatac 1722181 cgcccccatc agtccaattt tgccagtagt ctgtgctagc tgcagaggcg gttgccgaaa 1722241 acaagctaat actcattaaa gctgccgata atccaactaa gaaattcttt ttaaacttaa 1722301 acatatgtta cctcctataa tattttttcc gactttgagg tagcactcgt atacatttaa 1722361 aacattctta attactaacg ccaaagcttt tgatcgtccc cttcagtata ataccacgaa 1722421 ttcatgagca aatattaaaa gtatttgtaa ttcaattaca aatacctaga aacacattat 1722481 aagtggtctt cttccaccat atcctgatcc gagctcgatg tacatgcctt tacggcacac 1722541 acgaatgtgg cgtgtggtgc atcgcctcaa tacgcaaaga cgtttgcctt aggcaaacgt 1722601 ctttttttgc gttatccgat ttttgtgccg tttgggacag gctgatccgg ctgcaaaagg 1722661 acgacgtcgc cctggccggg tatgccgccg aggaccaaga cttccgattt aaatccggcg 1722721 atccggcggg gcggaaagtt cacgactgct atgacttgct tgttgatgag accttccggc 1722781 ttgtaacgct tcgtgatttg tgcgctcgat tgttttatgc cgatttcagt cccaaaatct 1722841 atcacaagct tgattgccgg tactcttgct tcaggaaatt cttccgcttt tacaattgtt 1722901 cccgttctga tatccaattt ctcaaagtca tcaataactg ccatatcaat aactcctttt 1722961 tctcctattg taaaggagat atacaatatt cttttaacta aagagccatc attttttatc 1723021 cgaatataag gtgtttcgat acaggcgggg cggcattcct gtgcttttcg tgaaccatct 1723081 tgtaaaagaa gaaaggtttt gaaagcccag cgcctcgctc acgacggtaa gagtttcatt 1723141 tctctccatc agcattcttt ttgcttcctc aaggcgaagg tcggcaatat agttctgcgg 1723201 ggacttccct gtctgttttt tgaaccagct tgaatagtaa gctgggtgat aatgctcgat 1723261 ttctgccagc ttcttaatcg tcagccgctc aaataaatgg ctgtgaatgt atgcaattga 1723321 ggcatagcta tgggattgaa gcttttcttt tatgtattgt actagcatat gaagcgagtt 1723381 ggctgttccg gcctttgctt cctctgtcag caagtacctg atcgaagacc agaaaggatc 1723441 gagggcagct tcaattcctg atcctgcacg atactcatca attttcattg catgaagcgg 1723501 aacatccagt acaagacatt catttcttcc gatagaacgg aagcgatgct cgcactgcgg 1723561 cggaatatat aaaaaatgat ccggatttaa tttcacctgg cgcccctcag tctcaagatc 1723621 aatactccct tcaagcggaa aaagaaattg gctgtacgcg tgcttatgtg aatgatatag 1723681 ccgtgtgtat gtccgttttt cgcaaattat ctcttgaagc gagtccatta gcaaacccct 1723741 tcctttggtc atcttttaat ccggtaatgg tgttccgata taggcgaaaa gccgattttt 1723801 ccatataaag aaactgccgc cagattttct ttcatcactt gtaaaaacat gcgttccgct 1723861 ccgttgtttt ttgcccattc agtcaacacc ctgatcactt gggttcctgc cccttttcct 1723921 ctgtgctcct cagctacaac gatattacta agtccgccat aaccatcaat gacagaaacc 1723981 gtgccaagcg ctgtcaggct ttctttgtca tacatcttga aaaaagtttt acacggcggc 1724041 atgcgttcga atatgtgttt gtaacctttg tgacgctcgg gtgaaaaccc ttctaattga 1724101 ataaattcat ctatccaaac agatgatggc tcttgttccc acttgtatgt aaatcggctg 1724161 ttgtcatttg ttcggctcat aattgaccgg cacaacgctg tcatctggaa gcactcgtct 1724221 accttttcat aacggctgtc tgccaatgcg tcatcaagcc ctttcggtga tgcgttgcta 1724281 atatgaaaac aaacaggtaa gcctaaactt tgataaaaaa gttcggcctc tagctgaaaa 1724341 tccccttcag gcatatccgc agacgtccat acgctatttg cccttttggt tacgccaaaa 1724401 ttcgctctga gaagccattt ccctatgctt ttttgaaaat aagccggcca tgaagctgcc 1724461 gctaatcgtt caatcttgcg aatgtcatcc attgcataat gcctctcccc tatgtatact 1724521 cccttgatat tatacaatat tcagaaatat aagacatcca tttatttgtt tacataatat 1724581 ttttattgtt tattaataat cctgacaaaa atgtccgaat tgaaaatgac aggctttcta 1724641 aaatgtcctc ctcacgttca aatgcttctt ttgcgattaa aacagtaaag ccatgcagca 1724701 gacttctgag cccccttgtc gcatgaatgg cagtcttttc acttgcatag ccgttttcaa 1724761 tgagcagctt cgtcacaaga cagacaattt ggtcagagac gatttccgtc cgtttgtcgt 1724821 gaaccttaag aagagccgct tcataatatc cgggattttc aattgcaaaa tcaacatatg 1724881 catgagctaa agaaagcatc gcggaatctc cctttcgttc ggttacggag tccgccattt 1724941 gatcaaaaag ctttgtcagt cctctgacag caagttctgc tctgatcgct tgcagcccgt 1725001 tgatatggtt atacaatgac ggggggcgaa cattcatttt tttagaaagt gcagcaagtg 1725061 agacaccatt taccccttcc tgatcggcaa tctctgctgc agcgtctaca atcatttttt 1725121 gggtcaaacc tattctcggt gacatgctca tcatcctttc tttgcttttt ggatcgcctg 1725181 tctcatccgc tctgaaggtg atcgcaggaa ttttccatgt ccgacagcga gacaggaagg 1725241 cgccttatcg gcgagcaatt gtgcactttt gatggcctcc tccttattcc atgtggcgaa 1725301 agcgggaaaa ggaaacgccc attttatctg acctgataca gcgattcctc cgcgcaactg 1725361 aaacgcatct cctgctatta aagtgccgtt tcttgtatca agaaatgaca tgctgcccgg 1725421 tgtatggccc ggtgttggaa tggcaagcag agaaccaatt gtttcaccgc ccgtcagcag 1725481 ttggtgaggc tttgtttgta tgtgtttcgg aatacctcct tttataggcg tctgcggctc 1725541 atcttgccgc aaagatgtgt caccttggag caagaatgaa tcccgttccg agatcatgac 1725601 ctttgcatgc ggaaatgttt gtgccaatgt atccagtgat ccgacatggt ccccatgtgc 1725661 atgagtcagt aaaatatgct gaagcggttt tccaagctga ttcacagctt gaataatccc 1725721 tttatagctg cctggcagtg cggcatcaat aagggtgact tcgttttctt cctctactaa 1725781 atagcaatta accggaaaca atgctggaaa aaaagtcagc tgccaaaccg tttggtactg 1725841 agtaattctc atctttttat tcctcctaac aaaaactaat ggtgttagtt ttattattaa 1725901 ctaacaccat tagtttttca agagtttatt atttttttat cgctacataa atgttaactt 1725961 gtgctcgctg tggcactgcg gcattttgat catacatctc aaagtcacct gtaaacgtgc 1726021 gcagatgccg cttatcccaa gtccaaattt ccttccacgt ttcaagcaca atctcttcaa 1726081 taggaccgat tctggaagtg aaaacggcgt aagcggaagc cggcaaatca atattttcat 1726141 atggtcccgg aagaatgtcg tcgtattcct gaaacgttcc gactgaaaac gtataaaacc 1726201 cattcgtctc ttgttcataa ttcgaatata aggcaataat gctcttgtct ttttcagcct 1726261 gtgataaaag agcgctcata tcctgcttcc ataattgatc ccacagtgcc ggaatcctcc 1726321 tttcttccgt catttccagt gcgttgcttg tccgttgtga tagtccggca aatcgtttca 1726381 ggtctaagtg tgttatatgt gaaaagccca tacgatctcc tccttttttt aagattatag 1726441 acaaagaaac ctgacagcag tgtgtcaggt ttcatatatt ttttgcatgt gatgaatggt 1726501 ttcttttact ttatccctta tatgaagagg ctgcagaacc tcaatatcct ttccgaactg 1726561 gagcaaaaaa ccgatcagcc attgatcttc tggaagtgaa atcaccgcct ggcagatttc 1726621 atcttcctca caacagtgaa ggacatcata tccgaaccat tcacctatac gctgacgtgc 1726681 tgacggctga acaagaataa ccaattcagt taaacggtcc ttttggtacc aactcttatc 1726741 ccatggcaaa gtgtccagct gaatgtcttt tctgataaat gtctgatgta agatggccag 1726801 atctttcatc cggttcagtt taaaaaagcg aaaatcattt cttaccaggc agtaggcata 1726861 taaataccag tgccccgcct tgcaaaccaa tgtataaggt tcagtttccc gaagtagtgt 1726921 ttccccgctt gcgcttgtat atgtaaaaga tatcgttaac aaccgatcga tggcagcgct 1726981 gattttctcg cgcagcgtct tttgatcctc agtatggccc caagccgtca tgtcaataaa 1727041 ccatttttct gtttggtgct taaatgcttg agtagattgc tcaggtataa ggtgtttgat 1727101 tttttgatag gctgtgctgt gagaaacggg ttcatacata gatgaaacgc tttgcaaagc 1727161 ggaagcaatt gcaaacaatt cctcctcctt cagccactct ctttcaagcc gatacgtttc 1727221 catgatgcca attccgcccc cggaaccctg tgaggtcaca atcggaatac cagccctatt 1727281 gatcgtctca atatcacggt aaattgttct gacagatact tcaaacagct cagcaagctc 1727341 tgcagcctgc acttgttttt tgctgatcaa taacacaacc atcgctaaca aacgttccag 1727401 tttcattctg cgcacctttt cttcttgtat tttccaacaa aacaatcata acattttgat 1727461 aaagcttggg catatctatt atgcggcgga atacacctcg catatgctat gaaaacaggg 1727521 gtttcccctt cttttttgtg ttcagtattt atttcagcta ctatttccga ccggataagc 1727581 atacacttct caacggaggg gatttcacat catgcatctt acacttcaga gcgtttatcc 1727641 tgccataatc atcatctttt ttctgtataa aaaaattaaa aggtccatcg gataccagcc 1727701 gctgaagccc cgctggctgt tcacccgtat cattcttttc tcgctgtttg cttttggact 1727761 ttcaatcttc agcgccattc accctttttt atatggatat ctcattttgg gcattcttgg 1727821 cggatggctc cttgtctttt tcgctaagaa aaacatctct tttgaaaaac gcagaggaaa 1727881 gatctatttt cggactcata tttgggtaga ggtgattctc ttaactttat ttctatcaag 1727941 atttctgtat cgagtgacgg agctttatct tacctcacct gatctaaacc gccttggatc 1728001 atacagtcag tcaatcggaa cggaccctct gacaattggc gtctgttttc tgatagccgt 1728061 ttattatatc ggtttttctt cttttatcat caagctcagc agaaacgaac ttgaacagca 1728121 cgaatacaat aaagaaaaag acatccttgc ccgctaacag cgagttaagc aaggatgtct 1728181 ttttcaatca tgctgtgtat gatggatcat ttgctgaaga acatctaaaa catgttcatc 1728241 ctccggagag taataaatcg atgttccttc tctgcgcgat ttgacaagcc ggagattttt 1728301 taaaaatcta agctggtggg acacagtgga ttgcagtaaa ttcagctttt ctgcaattcc 1728361 gtttactgca tgctcacctt gggacaataa atggagaatt ctgattcggg taggatctga 1728421 aagcgctttg aatgtttgcg cgactagaaa cagcgtctcc tcgtccagat cagcagccga 1728481 ttgttccgtt tctctaaatt cagtcatatg tatcaccttt ctttattcat agttttatct 1728541 tataacaaat gcgcttgagt gcaaaccagc ctgcttgtat tccatttcaa tctcatagtt 1728601 taaatttatg tttcaaatca ggtttttact tggtctgata taccctctta tgtcataata 1728661 aaaaaggtca tactgctcca aacattgagg gtgaaacaca gtgaagaaaa agagaaaagg 1728721 ctgtttcgct gctgcgggtt ttatgatgat ttttgtcttt gtcatcgcct cttttttatt 1728781 ggtcctgctt tttttcaacc gggatttaat caaaaaactt ccgatcgata cgaaaacgat 1728841 tgttttggaa cgtttaaccg attacaaacc cttggtggaa gaagagcttg aaagccaagg 1728901 actctctaat tatacatcac tcatattagg catgatgtat caggagtcaa aaggaaaagg 1728961 caatgatccc atgcagtcct ctgaatctct ggggttaaaa cgcaatgaga taacagaccc 1729021 tcaactcagt gttaaacaag gcatcaagca atttaccctc atgtacaaga ccggtaagga 1729081 aaaaggcgtg gatttggata ccattattca aagctacaac atgggggcag gttacattga 1729141 ttttgtagct gaacatggag gaacgcatac tgaggaattg gcaaaacaat actccgagca 1729201 gcaagtcaaa aaaaatcctg atctgtatac ttgcggggga aatgcgaaaa atttccgcta 1729261 tccgtattgc tacggtgatt atacgtatgc agaaaaagta aaagaaaaaa caaaaactgt 1729321 tgaagaatct ttgcaggttg caacacttga aaccatggaa tccaaggctc atgaataaga 1729381 gtctatcaat ttactgacaa aagcccaaaa atgaatttgg gcttttgcca tgtttacacg 1729441 taaaaaaagc catactgagt atggctttta ataatacggt gaaatcatca aatatacaat 1729501 aacgcctgta aggcttacat acagccatag aggcattgtc catctcgcaa tttttttatg 1729561 gcgctccacc tgcatgctga agcctctgat cagcgtaaac agcgcaagcg gcacaataat 1729621 tgcagaaagg cagatatgtg taattaaaat aaagaaataa atcgggcgca taataccttc 1729681 tccgccatag agcgtgtttt ccgcaatcga gtggtacgtc acatagcaaa tcaaaaatag 1729741 taatgttgtt gtgaacgcag ccaaaataaa gcgtttgtga gctttgatat ttttctgttt 1729801 aatcataatc agcgcggcca ataagaagat aaacgtaaag ctattgaata tcgcattcag 1729861 cattggcaaa atgtgaatat tcgcatggct gaactgatct aatttaggca taaaaaacag 1729921 cactgcgatt aaaccgttaa tcagaactgt cagcgtaagg acaatccccg tgtaattttt 1729981 cggtttattt tctgtttggt tcatttggtg acctctccta atttgtactg gctatccaaa 1730041 tcgtatgcaa attcaaagaa gatgtcaacg gtttcgattg cttcgtcaga aattagacac 1730101 acttcaaagg ccggaggcta ttagccccgg cctgttaggt ttacgcctct tttatcaaat 1730161 gttcaatgac cttatgttca ttttcattca gcaggttctt ttgaattttc gaatgaatgg 1730221 gtttattcat atgctgatcc aagatatcgg ccgtttcttt atccccggca ataaccattc 1730281 gttcccatct tttcgcggca gctttttgat caaggctggc agccagccgc ttatacagtc 1730341 tcgattggtt ctctgttaca tgttccctca tccggttctc ttcaaatggt ggcgctttgt 1730401 ctacagcgga atggctattc ttccaagact cattgatcat atcatactca taacgctcca 1730461 ccgcctcaat ttttcctaaa acagtttcaa taattttcac ttcatgctgc tgagttaaaa 1730521 taaacgccgt acttgggtat gtctggcgca aaccctttag ctgatccagg acagctgttt 1730581 cttcccagta aaatcttgta tctacaggga cttgaagctt aataggttcc catatgccgc 1730641 tgtcggaaac aaaaaacacg agactgcggg gcatgtcttt tcccattgca ttcaagtatt 1730701 gattcatttt agccctgatt ccatccagac acttttcctc ctctggatca ctagctgcca 1730761 aatactcttt taatcggctg aatcctgact ttagggcaat cttccattct cccccctgct 1730821 gctctggatc tctcatgtct gtattgagat acagagagag aattttatcc ggcggttcca 1730881 attggacata ctgtaatttg ttaatcaatg aatcaatcgc cattccgatt cctccttttt 1730941 cacaggttag ttttcttttt cctctcttaa aaacgatcaa acctgacttt ccgctaattt 1731001 ctagtaataa tggaattgtt gtttacaata cgcctctctt ctaatacaat tggtaactgt 1731061 gtttctaagc tgttttttga aaggagtttg atcttgttta ctgttaaaga aaaaaatcgt 1731121 caagagcttg aggaagaact aaatgattta gaatttcaaa tttatcgcat gcaggagaat 1731181 atgaaggatt tatctaaaga tgccaaagtg cttggtattg atcaatcgaa acatgatgag 1731241 tggatgattg tttcctcgat tgatgatggc caaacatgca aaattatgct aactgattgt 1731301 aaaacggcat accgaggaaa aggctgtttt tcacttgtag cgtcttacaa ggacgatgcc 1731361 attcatatag gggatataaa aggccctccg aatcacgggt ttggctccat ttgcatgaaa 1731421 tatttaaaag atattgcaag agaccataat ataccgaaag tcaccggaga catcgccaaa 1731481 cgggattgga atcatgtaga ccggctgatt cacttttatg aaaaacatca cttcaaagta 1731541 tgtatcgatc atgataccca atccggcagc attaagtggg ttgatttgta aaaaagtctg 1731601 gaagaaagag ccaagatatg ctgtaatggt ataaaaccat tgatggaggg ttctatgtac 1731661 gcctcaaaac tgaaaaaggg agacgaaatc cggatcgtgt ctcccgcgac cagcatgtct 1731721 atattatcaa atgaagcaaa aatccaagca aaaacggcgt tagaacgctt aggttatcgg 1731781 gtaaccatcg ctgaacacgc aaatgaatgt aacgaatttg attcatcctc tatcgagtca 1731841 agagtccatg atctgcacgc tgcctttttt gatccaggcg tcaaagcgat tttaacgaca 1731901 ctcggagggt ttaattcaaa tcagctgctg cgttatcttg attacgagaa aatcaaacga 1731961 catccaaaaa ttctgtgcgg ttattccgat ataaccgctc tttgcaacgc tatttatcaa 1732021 aaaacgggtc ttgttacgta ttcaggtccc cacttctcaa catttgcaat gaaaaaagga 1732081 ctcgattata cagaggagta ttttctttct tgctgcgctt cagacgatcc gtttgaaatt 1732141 cacccctcaa gtgagtggag cgatgatcgc tggtttttgg atcaagaaaa caggcgtttt 1732201 tatcctaata acggccctgt tgtaatccaa gaaggttatg cggaaggtac tttaattggc 1732261 ggaaacttat gcacgcttaa tttgctgcag ggaacggagt attttcccga aacagaacat 1732321 actattttat tgattgaaga tgattatatg tcagacatcc atatgtttga ccgcgatctg 1732381 caatcactca tccacctccc cgctttttca catgtaaagg cgattttgat cggcagattt 1732441 cagaaagcat caaacgtatc aatagatctt gtaaaagcca tgatcgaaac aaaaaaagaa 1732501 ttatccggca tcccgatcat cgcaaatata aatgccggac atacctcgcc aattgccacg 1732561 ttccctatag gaggaacatg caggattgaa gctatttcgg gtacatcacg aatatggatt 1732621 gataaacatt aatcagcttg taaatttttt tacaagcttt tttagcgcaa tcggctatgc 1732681 atgccgcacg agacatgaca aatgtcatat aggaggcatg atgtgtgcta ctacaaaaga 1732741 cttctctcat tagcgtatac tgaaccgaga cacacaatga gaggatactt actatgactg 1732801 aacaaaccat tgcacataaa caaaaacagc tgacaaagca agtcgctgca tttgctcagc 1732861 ctgaaacaaa aaacagcctg attcagcttt taaacacgtt tatcccattc ttcggcctat 1732921 ggtttcttgc ttatctcagc ctcgatgtct cctatcttct tacgttagca ttaacggtga 1732981 ttgccgcagg ttttctgaca agaattttta tcatcttcca tgactgctgc catcaatctt 1733041 ttttcaaaca aaaacgctat aaccacattc tcggttttct gacaggtgtc ctgactttat 1733101 tcccgtatct tcaatggcag cacagccatt cgattcatca tgcaactagc agcaatctgg 1733161 ataaacgcgg aacaggagac atctggatgt taacagtaaa cgaatataaa gctgcatcca 1733221 gacgaacaaa gcttgcatac agactttata gaaacccgtt tatcatgttt attctcggac 1733281 cgatttatgt ttttctgatc acgaaccgtt ttaacaaaaa aggcgcaaga cgcaaggaac 1733341 gtgtaaacac ataccttacg aatctggcaa ttgtcgcgtt ggctgccgct tgctgtctga 1733401 tctttggctg gcaatcgttt ttactggtgc aaggcccgat atttctgatt tcaggttcaa 1733461 tcggtgtttg gctgttttat gtgcagcata cctttgaaga ttcttatttt gaagcggatg 1733521 aaaactggag ctacgttcag gctgctgttg aaggcagctc attttataaa ctcccgaaac 1733581 tgcttcaatg gctaacaggc aatattggtt accaccacgt tcatcatttg agtccaaagg 1733641 tgcctaacta taagcttgaa gttgctcatg aacatcacga accattaaaa aacgtaccga 1733701 caatcacctt aaaaacaagc ctgcaatcac ttgcgttccg tctatgggat gaagataaca 1733761 aacagtttgt gtcatttcgg gctataaaac atatacctgt aagccttccg cctgattcac 1733821 cagaaaaaca gaagctgcgg aagaatgcct gatgataaag gaggtcttct aatatactag 1733881 aaggcttcct ttttattgtt ggagggtgca ttctggcttt cacaatgata aagttacaag 1733941 taagatgaaa agctgaaaat gaggtaagat catgattaaa aatcatttta catttcaaaa 1734001 actaaacggg attacgccct atatatggac gatatttttc atcctcccct tctactttat 1734061 atggaaatca tcatctacat ttgttattat tgtcggcatc attttgacgc ttttattttt 1734121 ttcggtatat cgatttgctt ttgtctcaaa aggctggacc atttatttgt ggggattttt 1734181 attaattggc atttcaaccg cctccattac tctgttcagt tatatttatt ttgctttctt 1734241 tattgcttat tttattggaa acattaagga acgcgtccct tttcatattt tatattatgt 1734301 ccatttaata agcgcggccg tcgcagccaa tttcagtctc gtattaaaaa aggaattctt 1734361 tctgacacaa attccttttg tcgttattac cctcatcagc gcaattttat tgcccttcag 1734421 tataaaaagc cgcaaggagc gcgaacgact tgaagaaaag ctcgaggatg caaatgaacg 1734481 gattgcagaa ctggtaaaat tagaagaacg tcagcgaatt gcccgcgatc tccatgatac 1734541 gcttgggcaa aagctttctc ttattggttt aaaaagcgac ttagcaagaa aattgatata 1734601 caaagatccc gaacaagcag ctcgtgaact gaaaagtgtt cagcaaacag cgcgaacttc 1734661 tttaaatgaa gtaagaaaaa tcgtttcctc tatgaagggc atccggctca aggatgaatt 1734721 gatcaacatc aaacaaattc tcgaagcagc tgacattatg tttatctatg aagaagagaa 1734781 atggcccgag aatatctcat tgctgaatga aaacattttg agcatgtgct taaaggaagc 1734841 tgtcacaaat gtcgtcaaac acagccaggc taaaacttgc cgagttgaca ttcagcagct 1734901 ctggaaggaa gttgtgatta cagtgtctga cgatggaaca ttcaaaggag aagaaaattc 1734961 cttttcaaaa ggacatggct tactcgggat gagagaacgg cttgagtttg caaacggaag 1735021 ccttcacatc gataccgaaa acgggaccaa gcttaccatg gcaattccta ataattcaaa 1735081 ataaacataa aggatggctt atatgattag tatatttatt gcagaagatc agcaaatgct 1735141 gctgggcgct ttaggatcac ttctaaacct cgaagacgat atggaagtcg taggcaaagg 1735201 tacaaccggc caagatgctg ttgattttgt caaaaaacgc cagcctgatg tatgtattat 1735261 ggacattgaa atgcccggaa aaacagggct tgaagctgct gaggagctaa aagatacagg 1735321 ctgcaaaatt atcatcttaa ccaccttcgc cagacccggt tactttcaga gagctattaa 1735381 agctggcgtt aaaggctatt tgttaaaaga cagtccgagt gaagagctgg ccaacgccat 1735441 ccgtagcgtc atgaacggaa aacgcatcta tgcacctgaa ctgatggagg acttatacag 1735501 cgaagctaac cctcttacag atagagaaaa agaagtgctc gaacttgtgg ctgacggtaa 1735561 aaacacaaaa gaaatcgctc aggaactcag catcaaaagc gggacggtgc ggaattatat 1735621 ctcaatgatt ctagaaaagc ttgaagtgaa aaatcgaatt gaagccatta cccggtcaaa 1735681 agaaaaaggc tggtttaaat aaaaaaggat cttggcatct gccaggatcc tttttgttaa 1735741 cctgaaattc ccgtttgaga acctcgtcgc aaccagaatt aaattgatcc atatcctcgc 1735801 tcctacgccc gctgaacgat tgtttggtta acagcccaat aaaagactgg attgaatgat 1735861 atccctgtta aaatggtcgg ccattgcaca tcagcagaat ttctgatatt gattatattg 1735921 tattttcagt atgacaaagt tgtgccactt cgctcccgaa gctgccatgc ccaactgcaa 1735981 gagcctaata tcacaataaa aaaccgtctg aaatcaatcc gattccgtaa atggtatctg 1736041 ctacatccaa ctgcttatta tctgccaaaa acaccagctc gtttcgctga tcaaagatag 1736101 taacaaccag ctataaatgt catgatgccg aatgtctctg taatgtggaa tcaatctttt 1736161 aacccgagag cccctgaatc gcacataaag aaaaacggga ccactttctt ttatcagcat 1736221 atgatataaa cagctctaag cagaacaaaa aaagacacaa gccaaaagct tatgtctttt 1736281 atcacaatct atattattag tttaagactt taacacttac agttttgacg ccccaattag 1736341 aagcatcact tttacttggt acaaatacgt cgattttatt tcctttaata gcgccgccag 1736401 tgtctgctgc tgttgcttcc ccgtagcctt caacatagac tttagaacct agcggaatta 1736461 cattaggatc aaccgcaata actttcgcgt tcgggttctt atttaagtca atgcctgtag 1736521 ctgtaacgcc ggaaatgccg ccgtcgttag cagtgtaagc agtagcagta actgttagtt 1736581 cttttgaagc ttcttgatta tttgtatttg attgaacagc cttctcctct gtgttaacag 1736641 aagtttctgc ctcagccttt gtttcttgtt taggttgctg ttgtacagct tcttgtttag 1736701 gttgctcttt ttgcacagcc tcttgttttg gcgcagcttg aggtgcgttt gtttgcgcat 1736761 tctcagtagc tgtgtttgct gctgttgcct gaccttttac tgaaagagtt gatccagcat 1736821 agatcatgtc agagcttaag ttattccaaa ctttcaggtt gttgactgtc gtgccgaatt 1736881 tttgagcaat cttagaaagc gtatctcccg ctttaattgt atattgccca gtcgtggttg 1736941 tttcttctga agaaatggtc agtttttctc ctgcaatgat tttatcagaa gttaacttgt 1737001 tccattcttt taagtccttt aggttcactc catttttctg agagattccc cagagcgtat 1737061 cacccttttg caccgtaatt tcttttgcag aagcgtgagc tccgaatgca gttgttgaaa 1737121 gtgcagcaac tgccacaaag gacataatcg tcttcttcat aagtaaatcc tcccttgtta 1737181 gctttttatt ggcggctaac aggtgatatc gtaacacacg taaatgtcaa atcaataaca 1737241 aaaagatatg atttagatta cagttccttt acatgaagga tttctctctg atggaaagac 1737301 ttgctgaacc cttgatataa taggcttcgc aggtcttttt attttgaggc gaaacagaga 1737361 aaataaaatg tgttttttat agaaaaaaag attgtttttc tgttttttta gtctgtcatc 1737421 cttgcataag cctgtatttc ttgtaaaaaa agccggccgt attttgctct tttttgttct 1737481 ccgactcctt ttatagacaa aagttcatca tcatttacgg gctgttttcc tgacatttct 1737541 tttaacgttt ggtcagagaa aacaacaaat ggcggaacac cctgctcagc cgcaatttct 1737601 ttccgaacca tgcgcaatcg ttcaaatagc tcgtcatttt cagtaatcgc tgccgctttt 1737661 aacgcttctt ttctcgctac tgataattct cctttcagca cattccttcc tttactgctg 1737721 acaaaaagag tcggaaacgt tccgtctgac atcctgatga agtcgtcaga aataagaaat 1737781 tcgataaaat cactgatttc gccaacggat tggtgtttta atatcccgta tgttgaaagg 1737841 tcggaaaagc cgttttcaag aactttttta tttttggagc cggcaagcac ctgggcaacc 1737901 atcgtcttgc caaaccgttc tttcatgcga atgatacaag ataagaccat ttgcgcctcc 1737961 cgcgtcacgt catgggccgc tcttgtatcg gtacagtttc cgcactgtcc gcacgcatca 1738021 ggctcctttt ctccgaaata cataaggata aaacgctgca gacaatcttc cgtatgacag 1738081 tagtcgacca tttgtctcag cttttttaaa tcctgctttt gtttctcttc atgttctgat 1738141 tgctcaatta agaagcgctg caccataata tcctgcggtg aaaacaggag aacacattca 1738201 ctggcaagac cgtcccgtcc agctcgtcct gcctcttgat aatagctttc catatctttc 1738261 gggatttgtg catgcagaac aaatctgata tttgatttat caatacccat tccaaaagca 1738321 gaggttgcca ccatcacttg aagctcatca ttaagaaatc tttcctgctg ctcttttctc 1738381 acatcatcag ccaaacctcc atgataccgg cctgccctga cctgatttcg tttcaatctc 1738441 tcatatatcc gatcagcttc ttttctggtc gctgtataga caattcctgc ttcatgcctg 1738501 ttgttttgca catattcgtc tataaaccga tctttatttt ctccttttac tactttaaag 1738561 gttaaattct ctcgggaaaa tccggtatat accgtgtttt ctttttgaat atgcagctgt 1738621 ttgcaaatat catcatgaac ctcgggtgtg gctgttgctg ttaacgccat gatgacaggc 1738681 ttgtcgtgta attcacggaa caagatttca atattcctgt agcttggcct gaaatcatgg 1738741 ccccattgag aaatacaatg cgcctcgtct attgcgacca aaggaacatc tatgccctgc 1738801 aaaatccgga taaactctat ggacgttagt cgctctggtg taatgtaaaa aagcttataa 1738861 gccccttctt tgagtccgtt cagcctctca tatatttcct gattggattg tgtgctgtta 1738921 atgtaggcgg cgttaatccc cgcttcttct aacgcatcaa cttgatcctt catcaaggaa 1738981 atcaacggtg aaatgacgat cgtcgtccct tcaaacatta atgccggaat ctgatagcaa 1739041 atcgatttgc cgcctcccgt cggcataatg caggccgtat tttgcctcgc ttccgtcacc 1739101 aagcggatcg cttcatcttg gccgctccga aacttctcat aaccaaaata atgagccaga 1739161 agggattggg ctctatgtaa cataacgtgt aaacctcgct tttccttgaa tttctcccat 1739221 catatcataa aaaagcggcc ttcatttctt tcacacaaaa atggaatatt cactatacca 1739281 aaccttttta gataaaataa aaagccattt ccgaaaagga aatggctttc gctacgtctt 1739341 gccgtatgca agtaagaaag ttttaaacca ccactcctca aagtgggtgt ttgcagaaac 1739401 gttcctgtcg tcctctgcaa tggaggcatg acattccggc ttcgatataa aactccctat 1739461 tacagcttaa aggttaaaac ttaattaaca atacgcacaa agtagcttct ttaatatagt 1739521 acaccatcag gcgcttttaa tcaagaggtc agaacaattg tttagaaaaa ctttttccag 1739581 tgaataaaac tgttttttct ccaaaatacc tgacaattcg acaaacaaaa aatatattac 1739641 aataaaaaaa atagccttta ttgctaaaag cgaatgatta ttttcttcta tattaatgtg 1739701 tatatacaaa aagactccta tttgtaacga taggagtctt ggctttatta gaattttgca 1739761 gcaagatctt ttgcttcttg taaacctttt tcaacgattt cttgcgcttg atcaggtgct 1739821 gcgttatgtc cttcgatgac aactgtgtgc aagtcttgaa caccccagaa accaagaact 1739881 gttttcatga agtttaatga catttcaagt gcagccattg gtccttctga gtagacaccg 1739941 ccgcgagcgt taagaagcgc aacttttttg ccgcccatta aaccgactgg tccttcttgt 1740001 gtgtatttga atgtaacgcc tgcgcgagac agataatcaa cataagtatg aagcactgct 1740061 ggcactgtga agttccaaag cgggaatgcg aaaacaactt tgtcagcttt tacaaactgg 1740121 ttcagatatt tgtcagcaat tgctgcttgt tttttctcat cttctgtcat ttccattcct 1740181 tgacctgctt taaatgttcc gttaatcata tctctgccaa ggtaaggaag gttttcctta 1740241 tgaagatcta attcaaccac ttcatcatta gggttgtttt ctttataagc agctaagaaa 1740301 gcttcgtaaa gtttagttga aacgccttct tcagctgtac ggtcgcttga ttttacaaat 1740361 aaaactgtag acatttgtat tcctcccggt aaacttttta tatttactta caaatagtat 1740421 gttactttct tttttacgta aagtcaatca ctttattttg aatatgagat tttttttcaa 1740481 aaaaaagcaa gtacatctaa tatcggtgta cttgcttggc atttttactt cgaatcttgt 1740541 tcacgatcca agatttcata cgtctgcgag cttttttgat caattgtttc tttgttggat 1740601 aagtctttta cctgttcatg aaactctctt tcataagaag gagcatctgt ctccagatca 1740661 tcctccacat cagcttgggc ctcaactgtc attcttgcat aaggaacagc ttcaagtctt 1740721 tcgtaaggaa tctcttggcc ggttttttca cacacgccat aagttccgtc tttcatcttt 1740781 tgtaatgcac ggttgacctc ctctaacagc tcccggtcaa tctctttcac tgtttggtct 1740841 gtcatccggt ctgtgacgag cgtcccgtgg tctgccatat ggttgtcaac cccattggaa 1740901 agctccccca cttcttccgt cattgattct gtttcctttt tctcgccaga caattctttt 1740961 tgcatatcga gcaatttatg atagagatgc tgtgtttgtt cttttgtcag tgccatgtat 1741021 atcctctcct ttctatcctg tttcccgttt tgccttctgt caaacatgga aacatcgatg 1741081 gaaagatgag ctactgcctt tttgaacgga tcgtgaccgc tggcgtcgat ggtgcttcgg 1741141 gttttcgttg gcactttttg tccttctctt ctggcggtat ataataggtt gcgcctatat 1741201 ttaatctgcc gctcagttca tcaatggtca gctcgccgaa ttcaagatga tagtcaactt 1741261 tttcgacatt cagcgtttca atatgtatat aggtttcttc agactcttgt ttgctgcttt 1741321 gtttttgttt ctcaatcact gagagtcttt cttcacattc acgcagtttg tcaagttctg 1741381 gtttcaagca atgcctgatc agcgaccgga acattttttt catgacatca cgaccctttg 1741441 catactcctc tttcgtctac atatataatg aggtatatcc catagaaagg agaggttttc 1741501 atgcttccga ctaacatcaa tatttctcat ctcaagacta actcgatagg caccggctca 1741561 tcccttacct ttggttctgc ggagttaagg aacaggtgct ctgctatcaa aagaaataac 1741621 ggttttgggg aacaaaatgc agatggtatt gttatggtca ttccgattga atcaattgat 1741681 gaccgtgatg tgtcagatgc actcagtatg aaaatcaatc atcaataaca atggttttcg 1741741 cttgaccttc gtctttttga atagtgatgt ataggattcc gtctttaaaa atggcattca 1741801 tctttccatg aagatgatcg gaaagcggaa ttttcttttc aaaacttccg tatttccctt 1741861 ctttttggcg aaagtcctgt tcattaaaat aggaaaagcg ctgccccttc accactaaat 1741921 aatctccgta cgataatatg tgaacgtctt gtttacggta gcctggaaga taaattaaaa 1741981 actgcacttc cgcaacggta tctacaatat ccatgctcgg aaatgaagca tctcctttcc 1742041 ctcgctgatc ttgctgcgca aacggaaacg gagattggcc atttgtcata aaaggggttt 1742101 tttggtcttc atcaaatacc tgtttccaaa agtcaccgcc gtacatctgc tgtgcgaatt 1742161 ccatccactg cttcatcttt tcgaaatcca tttgaagccc cctgtcttaa catactttat 1742221 aaccgccagc atacaactat agaaaggagg tttgcctgtg gttcaaccaa ctccgtatat 1742281 caatattaat attttcatgc tgaaaattaa ttcctttgaa aatgcttcag cggttaacgt 1742341 aggacaaaat ttattggcag aatggcaaaa ttcagataaa aaaaatcaag gctacggaca 1742401 gaattttgga gatgcgagcg gatttatggg cacgagaagc catgtggatg acagagacca 1742461 aattgattct ccggcctctt ttgaaagtga agcggttaac tcctcaatca aaaggaagtg 1742521 atgagatgtt cttttcaccc tccgtcgtaa atgtcggcgg atttaaaatc aatacgatgg 1742581 atcgaggttc ctctttaaca ctcggtccgt atcagcaggt cgattacttt ttatcagcta 1742641 aaataaatca agggtttgga gaagaaaatg gcgactttac tcctcttgtc gtgccgattt 1742701 caaatgtatt agatgcagat cttgttgatt cgaactcagc gaaaaacagt gtggtgtaat 1742761 aagaacaggg cgcacatgcc ctgttcttgt ttttatatat aaaaaaagcc taaccatttt 1742821 ttgaacggct ggctcatcaa atattcagct gcacaaatgc tttgtcagca ccgcctgaac 1742881 ctcgcttaaa tcggtgtctt tcgcaaattc taattcgaaa gttttgcttc ttgtcatcaa 1742941 taaaagccca gtgtccggat caaacattcc cgcttcttgg atggcaaagc tttcaattgt 1743001 tttatatgga agaaatacac gaaccttctt tttagaaaac attttattgt caaagaaaat 1743061 gatccgctta tttgtaaagc aaatttggtc cactcggagc ttataaatcg attcaattct 1743121 ttccccttca acgagcaaag cctcaagctt ctttgcgtcc gttgatctgc taacagaaaa 1743181 aatacccaat gaagaacccc tctttctgca tttatctatt tgttttatca ttcactacat 1743241 aaaaataagt cctttatccc tatataagaa tacgacatag aagacattta aaccattacg 1743301 aacagattac atttttcaaa tttttgattt gttttttggc ttttaagctg ttgtcatcaa 1743361 gtaatacgca catatagaga aaaaagtttc aatattcagc aatgttttta taaaaaagtg 1743421 gtttttaatg atttttttaa ttttgtttta tatttcctgt tttaaccaca aaaaaaccgc 1743481 agctgagctg cggttttatg tatcgactgc ttttaacaaa atctgtttga tgcttcaagg 1743541 aagcattaca tctcttcgaa gtattcttta taatagccgc cgactttatt cgtattgtcg 1743601 accacaaaga gaaactcctc tgtttcattt tttacttcat attcttttcc cggcgttaaa 1743661 acgcggttta cgatatattt ttttgcgttt gtctgcacac actttacttt tttaatggtt 1743721 tctttttcaa gccaattttt atgaatcatg atgaaatctc cttttcttat ctataagctt 1743781 attgtagctt ttttcttttg taaattgcaa tatcggttat tcattgattt tgccttgatt 1743841 tctattatag aatgtttgta tacgcttacg tttgaagcaa ctatcacagc ttatttctgc 1743901 tattcaatcc aggaatcaat gtgctatcac caagaatctc agaacagacc ataaaaaatg 1743961 actggaggtt tgttacggat gagttcttta acgatgcaag tgacgaaaag gctggagaca 1744021 tttttacagg gaacaaagaa gctttatatt gacggaaagt ttgttccgag tgcctcaggg 1744081 gcaacctttg acactccaaa cccggcgacc ggcgaaacct tgatgacgct gtatgaagcc 1744141 caggctgcgg atgtggacaa agctgttaaa gctgcccgga aagcctttga ccaaggtgaa 1744201 tggagaacaa tgtctccagc ttcgagaagc agactgatgt ataagctggc agacttaatg 1744261 gaagagcata aaactgagct tgctcagctt gaaacacttg ataatgggaa accgatcaat 1744321 gaaacgacta atggagatat tccgctggct attgagcata tgcgctatta cgccggctgg 1744381 tgtacaaaaa taacaggaca gacgattccg gtttccggcg cttattttaa ttatacgcgt 1744441 catgagcctg tcggtgtcgt cggccagatc attccatgga atttcccgct cctgatggcg 1744501 atgtggaaaa tgggcgcggc acttgcaaca ggctgtacaa tcgtcctcaa accggctgaa 1744561 caaacaccgc tttcagctct ttatttggca gaattaattg accaagccgg tttccctgcc 1744621 ggtgtaatca acatcatccc aggattcggt gaagatgcgg gagaagcgct gacgaaccac 1744681 gaagcggttg ataaaattgc ctttaccggt tccactgaaa tcggaaagaa aatcatgtcc 1744741 accgcagcga aaagcattaa gcgtgtgaca ttggagctgg gcggaaaatc gcctaatatt 1744801 cttctgccgg atgcgaattt aaaaaaagcc atcccgggcg ctttaaacgg tgtgatgttt 1744861 aaccagggcc aagtctgctg tgcgggctca cgtgtcttca ttcataaaga ccaatatgat 1744921 gaagttgttg atgaaatggc atcctatgct gagtcactcc gccaaggagc gggacttcat 1744981 aaagatactc aaatcgggcc tctcgtaagc aaggaacagc atgagcgcgt tctttcctat 1745041 attcaaaaag gaaaagatga aggagcaaaa gcagtgaccg gcggaagctg tccttttgaa 1745101 gcaggatatt ttgtcgcacc gactgtgttt gcgaatgttg aagacgaaat gaccatcgca 1745161 aaagaagaaa ttttcggacc cgtgctgact gcaattccgt acgaaacagt cgatgaagtt 1745221 attgaacggg caaaccattc agaatatggg cttgcagccg gactatggac agagaacgtc 1745281 aagcaggctc actatatcgc ggaccgactt caagccggaa ccgtttgggt caactgctat 1745341 aatgtgtttg acgcggcgtc tccatttggc ggttataaac agtcaggact cggacgagaa 1745401 atgggatcat atgccttgga taattacaca gaagtcaaaa gtgtatgggt aaaccttgaa 1745461 gactaacatg tatgtttaaa aaactgctgc ctgccagcag tttttttctt tctgtaatgg 1745521 cagtaaaaga cgctgaatat atatgcttct gaaggagttg agcgtgatgg gcacacttca 1745581 ggagaaagtg aggcgttttc aaaagaaaac cattaccgag ttaagagaca ggcaaaatgc 1745641 tgatggttca tggacatttt gctttgaagg accaatcatg acaaattcct tttttatttt 1745701 gctccttacc tcactagatg aaggcgaaaa tgaaaaagaa ctgatatcat cccttgcagc 1745761 cggcattcat gcaaaacagc agccagacgg cacatttatc aactatcccg atgaaacgcg 1745821 cggaaatcta acggctaccg tccaaggata tgtcgggatg ctggcttcag gatgttttca 1745881 cagaactgag ccgcacatga agaaagctga acaatttatc atctcacatg gcggtttgag 1745941 acatgttcat tttatgacaa aatggatgct tgccgcgaac gggctttatc cttggcctgc 1746001 tttgtattta ccattatcac tcatggcgct ccccccaaca ttgccgattc atttctatca 1746061 gttcagctca tatgcccgta ttcattttgc tcctatggct gtaacactca atcagcgatt 1746121 tgtccttatt aaccgcaata tttcatctct tcaccatctc gatccgcaca tgacaaaaaa 1746181 tcctttcact tggcttcggt ctgatgcttt cgaagaaaga gatctcacgt ctattttgtt 1746241 acattggaaa cgcgtttttc atgcaccatt tgcttttcag cagctgggcc tacagacagc 1746301 taaaacgtat atgctggacc ggattgaaaa agatggaaca ttatacagct atgcgagcgc 1746361 aaccatatat atggtttaca gccttctgtc acttggtgtg tcacgctatt ctcctattat 1746421 caggagggcg attaccggca ttaaatcact ggtgactaaa tgcaacggga ttccttatct 1746481 ggaaaactct acttcaactg tttgggatac agctttaata agctatgccc ttcaaaaaaa 1746541 tggtgtgacc gaaacggatg gctctgttac aaaagcagcc gactttttgc tagaacgcca 1746601 gcataccaaa atagcagatt ggtctgtcaa aaatccaaat tcagttcctg gcggctgggg 1746661 gttttcaaac attaatacaa ataaccctga ctgtgacgac actacagccg ttttaaaggc 1746721 gattccccgc aatcattctc ctgcagcatg ggagcggggg gtatcttggc ttttatcgat 1746781 gcaaaacaat gacggcggat tttctgcttt cgaaaaaaat gtgaaccatc cactgatccg 1746841 ccttctgccg cttgaatccg ccgaggacgc tgcagttgac ccttcaaccg ccgacctcac 1746901 cggacgtgta ctgcactttt taggcgagaa agttggcttc acagaaaaac atcaacatat 1746961 tcaacgcgca gtgaagtggc ttttcgaaca tcaggaacaa aatgggtctt ggtacggcag 1747021 atggggtgtt tgctacattt acggcacttg ggctgctctt actggtatgc atgcatgcgg 1747081 ggttgaccga aagcatcccg gtatacaaaa ggctctgcgt tggctcaaat ccatacaaaa 1747141 tgatgacgga agctggggag aatcctgcaa aagcgccgaa atcaaaacat atgtaccgct 1747201 tcatagagga accattgtac aaacggcctg ggctttagac gctttgctca catatgaaaa 1747261 ttccgaacat ccgtctgttg tgaaaggcat gcaatacctt accgacagca gttcgcatag 1747321 cgccgatagc ctcgcgtatc cagcagggat cggattgccg aagcaatttt atattcgcta 1747381 tcacagttat ccatatgtat tctctttgct ggctgtcggg aagtatttag attctattga 1747441 aaaggagaca gcaaatgaaa cgtgaatctt atcaagcgga gatgttcaat tggtgtgaag 1747501 ccctgaaaga tcagattcaa aagcgaggtc agcttgacca gtttgaagat caaatcgaca 1747561 agatgattga ggctctggaa gatgaccaaa caacagaaga agattggtat aaacaggccg 1747621 ctgcccttta tcgggatatt acagaatcag atgatacaag tgaaagacgc gcttatgtcc 1747681 ctatagggaa acacgtgctg ccaaagcttc cttacaaata ctccgcctta gaaccttata 1747741 tatcacgcga tattatgatc cttcatcata caaaacatca tcaaagctat gtcgatggcc 1747801 tgaacaaagc agaatcagag cttaaaaaag cgagagcgac aaagaattat gacttaatca 1747861 ctcattggga aagagagctt gcgttccatg gagcaggcca ttatttgcat agtatttttt 1747921 ggttttctat gcatccaaac ggaaaacggc gtcctacagg ggcattgttc caaatgatag 1747981 acctttcatt tggaagctat tccgctttta aagaacattt tacccaggcc tctaaaaaag 1748041 tggaaggcgt cggctgggcc attctggtct gggcacctcg atcaggacgg ctggagattt 1748101 taacggcaga aaaacaccag ctctttagcc aatgggatgt gatccccctt ttaccgcttg 1748161 acgtatggga gcatgcctac tatttgcaat acaaaaatga ccgggccagc tatgtcgatc 1748221 actggtggaa tgtcgtggat tggcgcgagg ctgaaaaacg ttttgagcag gcaaaagaag 1748281 tcgtttggaa gctctattaa aaaaagcccc ctttcctcgg gggcttcgtg tgttaaaaaa 1748341 tacctatcac atgcaaaaac acgatgatga tggcaacagg agatagatat cgaatgagca 1748401 gcagccaaac cgcaaaccac tttcgtttga gattggaacc gcttttcagc tcgtcaaaca 1748461 aatcctgttt cggtattttt agcggaacaa aaatcgaaat cagtaacgca cctaacggca 1748521 ttaaaatatt gctcacaaga tagtcagccg catcaaaaat agacagatga aatatagtga 1748581 cgtcacttaa gacaccgtat gataatgcag acggcacacc gacaataaaa atagcaatac 1748641 cgcctaacca agcgaatcgt tttctcttat tgatatcgcc tttcgacagt actgcgacca 1748701 aaatttccag cattgaaaaa gcagatgtca atgcagcaaa taaaaataga agtaaaaatg 1748761 ctaataaaaa gataattccg aacggcattt gattaaacac agtcggcaga acgttaaata 1748821 acagaaccgg gccttggtct ggcttgaggc cgaatgaaaa tacagctgga aaaatcgcaa 1748881 ttccggccat tacagcaaca agcatgttca taacagttac agatacagcg gactgtacca 1748941 gattttcctg tttctctaaa taagcgctat acgttaccat gacagataca ccgacactta 1749001 ataagaaaaa ggattgtccc attgcatata aaatggtatt ggcatcaatt gcagttaaat 1749061 caggcatgag gaaaaatttg attccttcca tcgcgccatc aagtgtaacc gaacgcacca 1749121 ttaaaatgat gaataataga aaaagcgccg gcattaatac ttggcttgct ttttcaattc 1749181 cgctgcttac cccttttgca acaactaaaa ttgttaccac cataaagagc agctggcctc 1749241 ctacagccaa ataaggattt gaaatggtac ttgcaaatat cgtatcaaaa ccagatgttt 1749301 gcgataaacc gccagtgaag ccttttataa tataaattaa aatccatccg cctacgacac 1749361 tgtagaaaga tagaagaata aagcacgtca ccatgcctaa ataaccgatc caatgccact 1749421 tcgttcctgg agcaagtgtt ttataggact gaacggcatc tttctgtgtt cttctgccta 1749481 tgatgaattc acctaacaat aaaggcagtc cgattaaaac cgtaaataaa ataaaaataa 1749541 gtaaaaatgc gcctcctccg ctggttccgg caacatatgg gaatttccat atcgcaccaa 1749601 gcccgatagc tgatcctgcc gcggctaaaa taaagccgag cttcgaagac cattgatttg 1749661 cttccttcac cgtatcactc ctatttgatc taaccattat aaaggttcat tgtaagaata 1749721 tcttcctata tagtcaagaa cattttaatt agtttacatc atatatctat agacatctgc 1749781 caaaaactaa tattgaatta ttcagaaaat tatttataat aagagaatgt tatgaaattt 1749841 gtaagaattt ctgctgaagt tcttgataag tgtgttagga gtgtttttat ggacatcatt 1749901 agaaaaataa gccattttgc aggacaaacc tttggcatat gggtcattgt ttttgcagtg 1749961 ctgggatttt ctttcccatc tttatttacg tggatcagtt cttatattac gatttttctc 1750021 ggcattatca tgtttgggat gggccttaca ctgcaagccg atgatttcaa agagctggtc 1750081 agaaagcctt ggcaagttat tattggagta atagctcagt atacgatcat gccgctcgtt 1750141 gctttcggcc tcgcatttgg gcttcatctt ccagctgaaa tcgcagttgg tgttattctt 1750201 gtcggctgct gtcccggggg aactgcatct aatgttatga cattcttagc aaaaggaaat 1750261 actgcccttt ctgttgcggt tacgacaatt tctaccttat tggcacctgt tgtaacaccg 1750321 ttgttgatta tgctgtttgc caaagaatgg cttcctgtct cgccggggtc tttgtttatc 1750381 tcaatcttac aggcggtttt atttccgatc attgcaggtc tgattgtcaa aatgtttttc 1750441 agaaaacaag tggcaaaagc cgtacatgcc cttccgcttg tttctgtcat tggcatcgtt 1750501 gcgattgtct cagctgtcgt cagcggcaat cgggaaaatc tgcttcaatc ggggttgctc 1750561 attttttcag ttgttatcct gcataacggt atcggttatt tactggggtt tctttgtgca 1750621 aagcttttaa aaatggatta cccgtctcaa aaagcgattg caatcgaagt cggcatgcaa 1750681 aactccgggc ttggggctgc acttgccacg gctcatttct caccgctatc tgccgtacca 1750741 agcgcaatat tcagtgtgtg gcataacctt tcaggttcta tgcttgcaac atattggtca 1750801 aaaaaagtga aaaagaagca agctggatcc aaaagcagca atctatcact ttaaatatgc 1750861 atcaaaaagg gtacatcact ttatcgtgat gtaccctttt ttattatcct tctaataaaa 1750921 gctgttcagg atcttccagt aaatttttga ttgtcacgag gaaaccaacc gcttctttac 1750981 cgtctacaat tcggtgatca taagataaag cgatatacat catcggacgg ttttcgaaac 1751041 gctcttcatc aatggctaca gggcgcagct gaatcttatg catgcccagt ataccgactt 1751101 gcgggctgtt taaaattgga gttgacatca atgaaccgaa agtccctccg tttgtaatcg 1751161 tgaaggagcc tccctgaagc tcgctaaggg ttaatttatt gtttcttgct tttttcgcaa 1751221 gctcgccgat ctctttttcg attcctgcaa atgtcaggcg atccgcatcc cgtacaaccg 1751281 gaacgacaag accttcatca gcagcaacag cgattccgat atcgtagaat tttttaacga 1751341 tcaactcatc gccttgaatt tctgcattca acagcggata ttttttcaat gcagccacga 1751401 ccgctttcgt gaagaaagac ataaagccga gcttcacttc attttgctca aaaaattgat 1751461 ctttgcggcg ttttctgaga ttcatgacag ccgtcatgtc cacttcatta aatgtagtca 1751521 gcatcgctga tgtttgctgt acctctacaa ggcgttttgc aatcgtttgt ctgcggcgtg 1751581 acattttttg cacttcaaca ggtttgtcaa agctttgctg tgctttttga gcctgaggct 1751641 gctgcttttg ctgaggagcc ggttttgatg ccggtttttc gtacgcttcg acatcctgct 1751701 tgcgcactct tccaagcgga tctccagttg gaacttgaga caggtcaatt cctttttctc 1751761 tcgcaagctt acgggccgac ggagaagcga tcgttcttga ttttgcttca gattgtgctt 1751821 cctcgctcac ctcttgtgca gctggttcag cctgtttctc ttcttttacg ctttccttgc 1751881 tttctgtttt ctctgtagga gcaggggcag aactttcacc cgcgccttct gaaatcgtac 1751941 cgataatttc tccgacctgg acggtatcac ccgaatcttt caatacctct tgaagtacac 1752001 ccgattcttc tgctgtcaat tcaacattca ctttatccgt ttctagttca agcagatatt 1752061 caccctgttc tacatagtca ccaggctgct ttaaccattg ggctattgtt ccttctgaga 1752121 ttgattctgc taattcaggt accttaattt ccgccatttt ttcatttccc ccttagtttt 1752181 tgcgagtcaa gctatcagat acaatacgtt cctgttcttt tttatgaact gtcggatctc 1752241 cctctgcagg gctggatcgt cttcttcgtc caatatattg aacgcttact ccctctggtg 1752301 caatctctgt caaatacggg ctgatataac cccaagcccc catgttctgc ggctcttcct 1752361 gcacccaaac gatttctttc aggttcggaa gttttgcaaa taattctttg actccttttg 1752421 ccgggaatgg atacagctgt tcgattctcg caatgtgaag ccactcttta ccgtcttcta 1752481 acttattaaa atgatcgcta atgtctatag acactttacc gctggataat acaagtctgg 1752541 ttactttttc atagtcatga gaaagtcccg actgttcata aacaggctgg aagcggcttt 1752601 cgctgagctc ctgcacttcc gacaccgtat ttgggttgcg aagaaggctc ttcggcgtca 1752661 taatgacgag cggtctgatt tcttcacgaa gcagcatttt agcctgtctt cttaaaatat 1752721 ggaaatactg tgccgcgctt gtcaggttgg caaccgtcca gttgttttcc gctgcaagct 1752781 gcaggaatcg ctcaattctt ccgcttgagt gctcaggccc ctgtccctcg taaccgtgcg 1752841 ggagcagcat gactaatccg gatttttggc cccatttcgc gcgtccggca gaaataaatt 1752901 ggtcaaaata cacttgagca gcgttggcaa aatctccgta ctgtgcttcc cacaaaacaa 1752961 gcgtttccgg tgaatgcacg ttatagccgt attcaaaacc gagaaccgat ccttcagaca 1753021 gcgggctgtt atgaacagca aatgatgtgc tgcagtcaga taagtgatga agcggcacaa 1753081 attctttgcc cgtctcactg tcatgaagca caaggtttct ttgggcgaac gttccgcgct 1753141 cggaatcctg tcctgttaaa cgaatcggtg ttccgtcttt caaaattgaa gcaaacgcga 1753201 gtgattctgc caaagaccat tccacttttc tgtcatcatc gaacgccttg gcgcgtcttt 1753261 ctaaaatgcg ctttagcttg ccgaaaacat taaatgactc cggccagttg atcaattcgc 1753321 cattcagctt gcggagcaca tcaaaatcaa tcgaagtgtc cacatctggg aaaccgtttg 1753381 atacaggctc tggaagttca atttcacaag cagtgtgttc ctttttagac ggaactttct 1753441 gatatgcatc ctcaatgcgc ttcgttaccg atttttcgat gttttgaacg acttcctcgg 1753501 taaccacgcc ttcttttacc agcttttcag cgaaaatttg tttgacggtc ggatgctttc 1753561 tgacagcatc atacagcatt ggctgagtgg ttgacggttc atccatttcg ttgtgtccat 1753621 agcgtctgta cccgatcaaa tcaatcagaa aatccttgtt gaatgttttt cggtattcga 1753681 ccgcaaactt aacagctgaa agacaagctt caggatcgtc cgcattcacg tgaacaatcg 1753741 gaatttcata acccttggcc aggtcgctgg catattttgt cgatctggat tcagcgcttt 1753801 ctgttgtgaa tccgatcatg ttattggcga taatatgaat cgcaccgcct acttgatacc 1753861 cttttaaaga gcttaaattc aatgtttcag ctacaattcc ttccccaggg aatgcagcgt 1753921 ctccatggat taaaatggcc agcgattttg tttcatcttg taccgggtat ccgctttgtg 1753981 ttcgcgtttc ctgtgccgct cttgtgctgc cttcaacaat cggattgata aattccaagt 1754041 ggctcgggtt gttcgctaac gtaatgcgcg ctgattttgt ttcagcgtct tgaagctccc 1754101 gattcgcccc caaatggtat ttgacatccc ccgtccatcc gtagctgatt ccaatggatc 1754161 cctcagacgg tacaagatct ttgttcggcg catgctggaa ttcagagaag atgatttcat 1754221 acggtttgcc gagcacatgt gccaagacat tcaggcgtcc cctgtgcgcc atcccgatgt 1754281 tgacacttgt cgtgcctgat ttgacagatt gtgcaataat gtcatcaagc actggaacaa 1754341 gagcgtccag accctcaatg gaaaagcgct tctgcccgac gaatgtgcgg tgcaaaaact 1754401 gctcaaagcc ctctacttct gtcaatcttt ccagcacagc tgacagcttt tcagctgagt 1754461 tcttctggaa cagctcgcca gattcaatct ttcttgtcag ccactcgcgc tctttgaagt 1754521 catgcacatg gtcaaattca aaagagatgg ttcttttata cgtatttcgt aaatactgaa 1754581 tggcttctaa accgttcgaa atgtttttag gagcgtcttt gcagatgaca gacgcaggta 1754641 ttgcttttat ttcctcttct gttagcccgt aatcggataa tggaaaaagt tcgctctttt 1754701 tctcatcctt tctgagcgga ttgacggaag cgttcaaatg gccataggtt cggatatctt 1754761 ctgcaagtct gactgcggat gcgatctttt gaatcagatc ggctgtaaca cgtccctttt 1754821 cttttgttcc cgaggcctct tttatatcgc ttggcggagc accgagctcg tcgaacattt 1754881 ccttcaaatc cgggtcaatg ctgttcggat cctgggtata ctgatcgtaa agctccagcg 1754941 catagccgag gttcggaccg taaaaatctt cccaattcat tcgttgtttc atactatttt 1755001 gaaacatttg aatattaccc ccaacttaaa taatcaagtg attgattcac tatcttgaaa 1755061 taactttcga acgctgtgtc caaaattatg taataaaaac gcttccaacg atattttacc 1755121 actgtttgca atttgattct accttgattg ttcacaaaat agtaaaaaac ctttataaaa 1755181 aacaaaaaat ttaatcattc gaaaaaacaa acgccaaaaa gcataggatt aagggctatc 1755241 ctatgctttt atgaagcagt tttttcagca gcggatacaa aacatccggt agctgatcaa 1755301 catccgggac aaatatactg aattttccgt acatatcctg gatcgtcttc atttgcgatt 1755361 cttctatttc tgagttggag agaaaaacat ttatcacttc tattcctctt tttcgggctt 1755421 cgataaccgc ctcacttgta tcaacgatcc cattttgttc gtagccaaat gcggccggct 1755481 ctccatctga gaaaacaatt aagaactttt gcgcctcgct gcgatgcagc atttttttcg 1755541 tcatctgcct aattgcgtac ccgtcacggt tatcttcttc tggctcaagc tgcataatgg 1755601 ccggtccaga atcttgtctt aatgatgatt ggaagggaat aaccgtattg aaatagtttg 1755661 gctggctttt ttcggttgca tcatttgtgt cctcccaaaa accgacaatc tgatgcggaa 1755721 ccgctaccga tttcaacgct tcgtgaaaca gcacgattcc tcgttttgtt tcgtccattt 1755781 tgtcgaacat gctggcggaa caatcgacca gcaatgtaaa aactgcgtcg atttctgaag 1755841 atggttcttg ctttttgtag aacaggcgcg gatttcgctc agtgaagtaa cgaagaagct 1755901 tattgttcag tctcccggca tgaaggtctg ttctcggcaa tgttttttta tgctccagcg 1755961 ttttttgaat catttgtttc aaacgctttt gatacgattc aatcgttttt gcctgctgtt 1756021 tataagaaag ctcttcttca ctggttgccg gctgcggttc tttataaatt ggaaatgcat 1756081 atttattttc tttgccgtca gccatacccg ctccgttcgg ctggtctttt tgggactcca 1756141 gcgcttccag cttggaatag tctttccgtt tcgtttgtct ggctgatcct tgaacagagc 1756201 caagggcctg atctccatcg tcgccttccc ttgaagcatc ttttcctaaa tctgattttg 1756261 cgccgtgttc aatatcaaat tgaaggaagc ttttagacgg tgcttctgtt tcccggtgcc 1756321 atgtcggcat ttcttcttca tggatatcct catcaccgtc tgattgtttt ggaagcgtga 1756381 tgtcatcact cagcttcggc gcttttttct cttcttcaaa taacggctgt tctgcagctt 1756441 ttgcgtaatc aagctcaggc aaaaagaagt aggtgttcaa catgtcttta tcgagtacct 1756501 cttcaagtcc gtccatgagg tcctcaacaa ttttcagaac ctgccgtgtc gaatctgctt 1756561 catacacacg caagagctgc tgctcaataa acgggcgcat cagatcgata tcttcacgca 1756621 tggatggaag ggtctcgagc ggcgattccg ctgtgagctt gaaatagatc gcgcaaaaga 1756681 gcgcatcggt aaaaatgctt cgttccaaat ttaaggtcag ctgggttgag aaatgttttc 1756741 tgtacatgtc ttttcgcttc gcaaatacat gtttcgtacc cgggcgctca cgtttgatgc 1756801 attcttcgat cctaatgtct tcaagcagca taaagagctg cttggcaaaa cttttaaacg 1756861 taagatggcg atggatatca ttcaaaaagt tcgcaaactc atgcagcgag ctatatcttg 1756921 ttccgactga acgcaggtag acgtcgcttt tcagacccgc ttccatgtcc tcagctgccc 1756981 tgtctttcca aaagtggctc atatagattt tcttttcaaa tggattgtaa taggactgaa 1757041 cgccatactc cacttctacc gcttcactct tggtgagtgt tttggccaaa tcagtcagca 1757101 tcataaataa aaatgaatca atcgtgctgt cgttaaattt gataaatttc atcgcagccc 1757161 cctcattcaa acagagtttc tgcaatattt cggacagccg ctttttcccg atcatcatca 1757221 agcttttcta caattccccg ctcaatggca cgacgcggcg gaatataagc agctaaatca 1757281 catgtatcga ttaaagctct gatggatgcc gcttcttcag acacctgtcc gttattggcc 1757341 tgaacgatca agtcagagga aagcgtgata aatctgtcaa tcaatttctc gtctttcaag 1757401 gctgactgag acatgagcac ttgtttcagc agctcgcctt taatataagg cacatcaatg 1757461 atgacaaaac ggtttttcaa cgcttcattc agaggaacag ttccgacata gccttcattg 1757521 atggctgcaa tgactccgaa accgctttta gcccgtatga cctcgcctgt aaacggattt 1757581 gtcatcattt ttctgtaatc taatacaccg tttagaatag gcagtgtttc cggcttcgcc 1757641 atattgattt catctatata aagaaaatgg ccttccttca ttgcctttgt aacaggtcct 1757701 gaaacaaact cgattgttgc ctggccagat tgattttcaa tcgttttata accgaccaat 1757761 gcctcagcgt ccaagtcgac tgaacagttg acgctgtgca tcggtttatg aaaatagctg 1757821 gacaatgttt ctgccagctt tgtttttcct gaacctgtag gccctttcag caggacattt 1757881 ttccccatgg ctaatgcaat aatggcgtca aataaaatgg cttcatcctc cgcctcatag 1757941 cctgatgttc ctataagcga ttgaaactct ggggaaatag gctgctcttt atatgataaa 1758001 agcttttgtt gtatatcttc cggcaatgtt aagtgctgta gttgagttgt catagacaga 1758061 ttccctttcc tattcatatt ccattaacga gtatactaaa aaagcccctg tatgctcaat 1758121 acaaaagggc ctggatgata ttactgcttc tcgttatttc ccaaaagggc tccgcagaca 1758181 atacgcgcac cggaattgcc gcttgggttt gtcagataat cgtccgcttg ttcatgaata 1758241 ataaatgcac ttccgtcctc gtcgagaata tttagtttac ttcctttttt cagtgaagtg 1758301 tcaggcgcat tcattatgac atctaccttt ccatcagcac cgacttcaag gttcggcaga 1758361 tctccggcat gatgccccat cggattatta aagccgtgtt ctttgttcag tggattaaag 1758421 ggaccgcccg ctgattcaaa atccggcctg acacaagaac ctttctcata aatatgaaaa 1758481 ccgagagaag cacctggacg caggctgttt gcggaaatat gaatatcgag gccttcatca 1758541 tctgattctt tgatctctat aaaaccgact gctttccctt cacgattgac cagctggaca 1758601 tgatgaccaa acgctgacgt ttcaaccact tttttttccg gcacccggtt aggagggtct 1758661 ggaggttttt tttgtccgca tccggcaact cccagtgccg tcagcatcat caacagcaag 1758721 agacggtgca tactgtctcc cccttgtttt ttctaacagt gtggtcaatc attgtctggt 1758781 ataaacaaaa aagcctataa aaggcttttt gtcatactca tttttaaaaa taacttcttg 1758841 cgcccaagta ccgctgtttc caatacgaat tgctgagatt ggaaatgtcg acgcccgatg 1758901 agcttgcatg aataaaatca ccgccgccta gataaatccc catgtgagac gggccggatt 1758961 tatatgtggt aaagaagaca aagtctccta ctgacggctg gctgactttc tgcatgacat 1759021 tccaataccc tgccgtactc aatcttgata tagatgatac attattaatg aggtaataaa 1759081 tgaagccgct gcaatcaaaa ccggcaggcg tgtttccgcc ccatcggtaa ggcactccga 1759141 catatttttt cgcttccgtt atcattctgt caatcttcga acctatttga atgtttgacc 1759201 ctgagttatc ttttggcttt gttggctttg tcggatttga aggattagat tttgatgctc 1759261 ccgaaatagt cagaacctgc ccgatttgca acacatccga tgataaattg tttttatcac 1759321 ggatgctttg gacagtgact ccgagccgat ttgcaatttt ccacagcgaa tcgcctgctt 1759381 ttaccttgta cgtcgttgtt tttgagggat tggagtttga cggctttttg gaaccgctgt 1759441 ttccgttctt aggtgaactg cttcctttta ttttgagcac ctgtttagga taaagtgtat 1759501 ctgatgttaa gccatttaag gtttttaatt cggctacagt catatttaag ctgtttgcga 1759561 ttttccacag tgagtcacca agcttgaccg tatatgtact ttttgaagaa cctgaagaat 1759621 tggaaccgct gtttttcttt gatccatttg atccgcttga actgcttgtc cctttgatct 1759681 taagcttttg ccccggacga atcaggtcac tgctcaggct gtttaagctt ttaagctcag 1759741 aaacactcat tttatgattt ttagcaatca tccataggga atcaccatat gcaactgtgt 1759801 atgttgatgt tttgcttgaa ttagatgggg atgtcgtgct ttttttgctg ctttcaggaa 1759861 ccttaagact ttgtccgaca taaagcaccg ttgatttcaa tttgttttcg gatttcagag 1759921 ctgatattgt cgtatcatac tggcgggaaa gtttccaaag agagtcaccg ctttttactt 1759981 ttatcgtttt tgcttccgcg ggtgctgcgg ccatcgacga cccaacaact gcagaaacag 1760041 ccaagccggc tacaatcttc tttttcattc attcaacctc ctaaactgtt tttttgcaaa 1760101 aacagctagt attttgtttc caaaaatggc acacaactgt tttatcgtca atttttcagc 1760161 aagttaaacc cttttcaaac atttggcgca gcattttcag catcgttcga cctttaaacc 1760221 ttcaaataaa catctaacat tttacataag cacgatatgt ttttcgaaag tctaaggaac 1760281 tatttaagcg agggtaaaaa tgatggtttt ctattgatga acgaagcagt ttctcctcct 1760341 ttcttgtcta tttttctaat caattctcta tcggcgtgtc aaatcccttc ctctgcattc 1760401 ttatgaaatg gcaaaaagcc tgttctttcg ataagaacag gcttttacac tatgcatttg 1760461 ctgattgagt tttttgtttt acagcttcaa gaatgctgtc ggctgctttt ttagagccgc 1760521 ctgccgcttt cagtgattgt ccaatttctt ttgccttttc agcatacgaa cgattattca 1760581 ttacttcttg tatcgtctct ttcagtaggc tttcagacaa ttcttccttt ttaattactt 1760641 ttcctgcgcc gactttttct acctgatctg cgacaacaaa ttggtcgcct cccatcggaa 1760701 tgacaacgag cggggtttca aaatacaaac cttcacttgt gctgttcatt ccgccgtggg 1760761 tcacaaataa gctggctctt ttcaagatct caagctgagg gacatacggg cgtacaatga 1760821 aattctccgg aatgtcgttt aactcacttg ttttaatatg cttgccgatg gaaagcacaa 1760881 ctttaccgtc aaagtcctta cacacttcaa ggcattgatt aaaaaactgc ttttgattat 1760941 taaaaatggt tcccattgaa ataaacagca cgttttcatt gtcaatctga tcaaatggga 1761001 aatcattgtt tccggctctt tctgtaatgg aaggaccgac aaatacatat cgctcgccaa 1761061 attgctcagc cagtggctga aatccccttg atgtaaagac gattgtcaag tcaccatcag 1761121 ctaaaaaaac atcaaatggc ttcttgatct ctgcttgaaa atcagcattt aacgtttctg 1761181 caagctgctg gtatgattca taatgaggcg aatcttcaag tgatcctttc atgtacgctc 1761241 ccatcatttc cttcgcaaat tcctcattca tcgcaaaggt tgtacacaat gaaaatcttg 1761301 gcagcttcag catgttggca atgactttac ccgcgagaag atggtgatca tatatgacat 1761361 aatcatacga ttcatgtttg acttcctcat aaatatgagt cgcgatatcc ttacaggctt 1761421 tcaaaaaagc gcagagcatt tctgtgaaat ctctttcttc atcgccggtt gcgtttttcc 1761481 cgaagtaatc tcctctgaaa tcatgatact cacgaaactc tatatcaaga gctgtgattt 1761541 tttctttata ttccttcact gcgtagtacg taatgttttc tccccgggat ttcagctcct 1761601 tcatcacacc gatagaggga ttaatatgcc cttcaccggg gaaaccgatc attaatacat 1761661 tagccatgcg gcagcaccct tcctttgaga atttatgtaa tattttatac ggtactataa 1761721 atgcataaac aggtaaagta tttcacttaa ttaatattca tcatatataa cttttctacc 1761781 agtttatatt ccctgtcttc aagacaaaaa gcattcagct tgaagcgaat gctttaataa 1761841 agatgcgaat tcagtcattt tgtctcatga taggattctt aatcaggccc tttttattat 1761901 ttttacgttc ttggtgaaat taacggatat aatacaccgt ctttggcaaa cgacatcttc 1761961 cctgtttcct ctgaaaccac gagcaccagt gcatccgtat agcccgacat accaagagcc 1762021 gcccggtgcc gggttcccaa atggatatcc acttccttcg tcgtcagcgg gagcacattg 1762081 gctgctgaca cgagtttgtt ttccctcact aataaagcgc cgtcatgaag agggtttccg 1762141 ggaaaaaaga tgctttcaat taatgaagag ctgatctcgg cgtgtaggga ggtgcctttt 1762201 tgaataaaac gttcaaccgg gtctgctctt tcaatcacaa ttaaagctcc atgcttatgt 1762261 tccgataagg ctttaatcgc cttggccagc tcaataaatg ccggcgtaaa ttcctcaatg 1762321 tatgattgca aataaaagga ggatgcaatc ccctgcatgt cctgaaaaac gtgccccaaa 1762381 tcatctaatt cacaaaggag acactggtct ttttcgtgaa gcgttttcaa gattagagat 1762441 gcatcaccta atatttgctc taagtacacc tgtattttcc ccttgaacgc attttctgat 1762501 atctgctcat agcgcatagc cttcatctcc tgtttaaatt tccaactttt cacgaatgct 1762561 tatcttattg atgcacattc tattggtaaa ggagggatgt aaagaatgga aatcgaaaga 1762621 atcattcagt atatttgcac ctttttaggc gtgatttcgc tttcttttat ttatgcccaa 1762681 atgtttagaa aaacgaaacc gacaaaaaaa gaataggccc ggcgttcatt gctttttata 1762741 cataaaatgt tataatttct ctcgttatga aaaagaaacg gagatcaatg tatgaaagaa 1762801 actcaaaacg cccgggaaaa aatcaaacag ctcttgcaca ttttaatacc gatattcatt 1762861 acccaagcgg ggctttctct gatcactttt ctagatactg tgatgtcagg gaaagtcagc 1762921 cccgctgatt tagctggtgt cgccattggc tcaagccttt ggacccctgt ttacacagga 1762981 cttgcaggta tattaatggc ggtcaccccg attgtcgctc agttattagg tgcagagaaa 1763041 aaacagaaga ttccctttac tgttttacaa gctgtatacg tggccgcgct tcttagcatc 1763101 gccgttttag tgattggata tgctgcagtt gaccttattc ttggccgatt gaaccttgat 1763161 attcacgtgc atcagattgc taaacacttt ttaggctttt tatcactggg aattttccct 1763221 ttatttgttt acaccgtgtt gagatcattc atcgactcat taggaaaaac gagagtcacc 1763281 atgatgatta cactcagttc tcttccaatc aattttgtat tgaattatgt atttatcttc 1763341 gggaagttcg gaatgccggc acttggaggt gtaggcgcgg gactggcatc cgcgttaact 1763401 tactggtgta tatgcatcat cagttttttc attattcata aaaacgcacc gttttctgaa 1763461 tacgggattt ttcttaccat gtataagttc tcttggaaag catgcaaaaa tttgctcaaa 1763521 atcgggctgc ctattgggtt cgccgtgttt tttgaaacga gcattttcgc agctgtcacg 1763581 cttctcatga gccattttca tacagtgacc atcgcgtccc accaggcagc catgaatttt 1763641 gcgtctcttt tatatatgct gccgcttagc gtgtccatgg ctctaacaat tgttgtcgga 1763701 tttgaagcgg gtgcagcccg ttttaaggat gcacgctcat atagcttaat cggcatcatg 1763761 atggcgatcg gcttttcttt gttcactgcc gcctgtatcc ttttattcag agagcaaatt 1763821 gcgggcatgt acacttctga ccccgatgtg ctccggctga cacagcactt tttaatttat 1763881 gcgctatttt ttcagctttc cgatgctgtt gccgcaccga tccagggagc actcagaggg 1763941 tacaaagatg tgaactatac gcttgcggcc gcttttgtct cttactgggt cattggcctt 1764001 ccggtcggtt atatggtcgg tacgtttaca agcctcggtg cattcggcta ttggattgga 1764061 ttaatagcgg gactcgccgc cggagcagtt gggctgtttt tcaggctggc aaaactgcaa 1764121 aaacgttatt cgcaaaaaca acacatttaa aagaggtgat caatcatggc aaaaaacaaa 1764181 aaattattcg agtatctttc ccagcatgcg gaaaccatca gttcaacatg gtatgaaaca 1764241 atcgaggaga ctgatcccaa ttccatttat gcctcaacag accctgttgt cattcacaat 1764301 ttaaagagcc agaatcttgc ctttaactat aaaataaacc gtatttttat agatgatgag 1764361 gacgtatact tgcctatact gaaagaatgg gcctttgaag tcacacagga tcaagagcat 1764421 ttaaaaactc ctatccacta tattattcgg gagtttgtca gagtgagaga tttatatgtt 1764481 tcttatgtga aagaatttgt ccatctcaat cagaatactg tgaaaagcga agaagccgaa 1764541 gacctgtatc acgcccttat aaaagcgttt gatcttgtga ttcatatttt tatagaagaa 1764601 atgtacaaaa acacaagcct tcagcttcag gcccaaaaag atatgattac tgaattgagc 1764661 gctccggtca tcgtgctgtt tcacagcgtc ggactgctgc ctttaatcgg agatattgat 1764721 acagtccgcg ccaagctgat tatggaaaac acactgcatc aatgtgcgaa aaaaaaggtg 1764781 acacaactgt atattgattt gtcaggagta gctgtgattg atacgatggt tgcccatcag 1764841 ctgttcagtc tgattgaggc gcttcgttta atcggtgttt cttcaacttt gtctggaatc 1764901 cgtccggaaa tcgcgcaaac agcggttcag ctaggtttgt ctttcgaagg tatttccttg 1764961 agatccactc tcgcttcagc tattgcatcg gacttaaaat taaaaaaggt ataaggctta 1765021 aggccttata cctttttgat taatcattcc attgatacgt ccaatatatt tcttcttcaa 1765081 accatgttgc cataacaggt tcattatttt tcaatttctc ttcaagctct ctgagcatgc 1765141 cttctgtttg tgtgcggtga gctcttaacg cattcatttt aatatcagct acttctttga 1765201 tatcaagtac gacatcagct tcgccgagaa cctcttctct gttgcgggta atggccatgc 1765261 agattgtacg cggacggtct tctttctttt tgcggtataa tgcacggata accgcttccc 1765321 cgcatgcatc atggtcaggg tgcacaccgt gtccgggata aaatgtgaca attaaacttg 1765381 gttttacatc atctatgatc tcttccatga tatcagctaa atactcatcg tcttcaaatt 1765441 cgagcgtttt gtcacggagt ccaagcatcc gaaggtcatt gatatccatt tctttgcaag 1765501 cgttgatgag ctcttgtttt cttagcagcg gcaacgtttc ccgattcgcg aaaaatggat 1765561 cgcccatatt tctgcccatt tcacctaaag tggcgcaggc atacgtaacg ggaatgtctt 1765621 tttttctgtt taaggcaatg aggcctgcca ctccatatga ttcatcatca gggtgaggca 1765681 ggattactag tacatgttct ttcattatta ttcacccttt tctttaaact gtgaacggtt 1765741 tttcgctgat ttgcagagaa atagccagtt taccgcccgg caggtgtccc gccattaata 1765801 aacggttttc ttcatctacc gtgtattcag tcaagccttc agcataaatc cagccttctt 1765861 ctgttttcaa gccaacgcgg taaggcccgt tgcctttgat ttttgcctga tgataagtga 1765921 cttttgcatt gcgaatatac gcaacaaccg tcatgttctt ttcatttaag tgcgctgaat 1765981 aagaacctgt ggtggtttct aaatggatat atacagggcg gtccgcatat cgttctaaag 1766041 atgcttgcac atcttctttt atgatcgctt tcatgattgc tcccctcttt cttcttttaa 1766101 atactctgca cgttctgtat gtaatttgac cagctgatat ttcacagccg gttcgagctg 1766161 tgaattcaca atgcgctgaa tcgcggcaaa atatttttcc agcatcggtt ttcggagtct 1766221 tggatgtgtt cgtttatcca agagctcaag atcaatcgcc tctgctaccg cttctgcgtc 1766281 atcatgtgcg agagatcggt tattccaaag tgaagcatag gctttcacta tctctttatc 1766341 attgtccatc gtcttgctcc tttatgtctt acatacatga aatgattata cataatatat 1766401 gcatcagctg aaaagccaaa ggcctcaatg gctttttgac gcccgtttcc acttcacttg 1766461 tgaaaacgta aacaagagca gcgcagccca tatacagctg aatgtaaaag ccttcgagct 1766521 tgaaaatggc tcatggtaaa caaacagccc gatcagcagg gtaatggtcg gcgcaatata 1766581 ttgtaagata ccgacttgat acagtggcag ccgtttcgct ccttccgcaa acaataagag 1766641 cggcaaagcc gtaaacacac cggccaaaaa gagaagcagc cacgtccctc cgctttctgc 1766701 acccgctggc tgaacatgtc cgctgaacag caaatacccc aatgcaatgg gcataatcat 1766761 gaatgtttcc agcgttaaac cgatggcgct cggcaggctt gttctttttt tgcttaaccc 1766821 gtacagccca aagctgaatg cgagcagaag cgcaacataa ggaatggagc cgtattggaa 1766881 cgccgagatg atgacaccgg ctgccgcaat cgaaacggcc actaattgca ggcgattcag 1766941 tttttccttt aaaaataaaa tcccaaggag cactgataca agcggattaa tgtaatagcc 1767001 aagactagcc tcaagcaaaa agccatggtt gacagcccat atgtatacaa accagttgat 1767061 cgaaatcagg atagaagcaa gaaataaaga gaggatccct ccgttctttt tcagagagcg 1767121 caactcctgc catcctattt tccattgccg caagaaaaaa agtacgatac acataaaaac 1767181 aaaagaccat ataatacgat gagccaaaat atcaagagcc ggcagctgtt cgagaagctt 1767241 ccaatagagc ggaaacaggc cccacatgat aaatgaaacg gctgtgtaaa taacgccttt 1767301 ttttgtttct gcatgttgca ttgatatccc tgcctttctt tagagcatct tatattatat 1767361 cacgtgaaag atctggtggg catatactat tttgtccgtg aagaaaggat gtgaagacaa 1767421 tgtttgagtg gaacaagtac tttcctttcc acaatcaatt ttctaaagaa gcattaaaaa 1767481 aagctgatcc gaaagaagtt gaaacgtatg tcaatcgtgt gatggaaagt gtgttcggca 1767541 gtgattatgc ggctcaattt cctttccgcg atcctctccc ccaaaaagaa catcccgcca 1767601 aacctgatgc aaaacctgat gtcaaacctg atattgatat attcgaaaca gcagaccatg 1767661 tgtttgtaaa ggtgccaatc agcgaagaat ggctggaaca agtgagaatc aaacacacat 1767721 ctcacgaatt atggttggaa aacctcccaa gagcagatca tccgaaaaaa gtaaaccttc 1767781 cttgtttagt caaacgcaaa ggaacaaaag ccgtctataa ggatggcctt ctggaagtca 1767841 tgtttcaaaa gcagcaagac tacaatatgt ccgaggtaga aatcatccga taaaaaacgg 1767901 cctgcaatcg atgcaggccg ttttttatta atagaagccg ggatatcccc cgtatggcac 1767961 gccggcacca aaaccgtacg gtccgcctcc atatccataa gggccaggag gataggcata 1768021 gggacgagaa tagttaaaca gcgcactccc gagaaaaccg cctaataaac cgccgactag 1768081 aggagcgcca aacaaaaaag gactacgcgc cggatatccg gctggacctg ggattccgcg 1768141 taaatacgaa tgatgagggt acatgatttt ttcctccttt atgtctgcct atacgtaaag 1768201 tattcagcaa ggaagaaaaa cgattgggct acggactgtc tatgattgtt acatcacaag 1768261 ccctgccaat aacacacagc cgagccctgt aaccgaaaga actgttgtaa gcagcgtcca 1768321 ggtttgaaat gtttctttca tgctcaagcc gaaaaattcc tttaccatcc aaaatcctgc 1768381 atcatttaca tgacacgcaa tgacactgcc ggctcctgtt gcaagcacca ttaacgcagg 1768441 gtttacactg ccagcctcca taagcggagc tgccattccc gctgtggtaa gcgcagccac 1768501 ggtagcagag cctagacaca gacgcagaac cgcggcgatg gtccatgcaa cgaatagcgg 1768561 cgacatgttt gtttgacgga aaaaatcagc gacataatcg ccgactccgc cgtcaatcag 1768621 cacctgttta aacgctcctc cccctcctat gatgagcagc atcatcgcaa tttgcgaaat 1768681 tgattctgaa atagatctgc cgatttcctg catagatatt ttacgggcat atcccatcgt 1768741 atagagtgca agcaacagcg aaatgagcat tgccgttccc ggagtgccga taaattctat 1768801 aatgtctttt ccttttgaat gttcactcaa taataaagaa aaaattgttg ccattgccat 1768861 aaagataacc gggaataaag acgtgacagc actgatcgca aagcccggtg tttcatccag 1768921 ctgaaattct ttccttggtc ctaaccccga taggtttcca tgcttttgat acgcaccagg 1768981 aaaccgtttc atcgcaaatt tattaaataa aggcccggca atcacagttg tcggaacagc 1769041 gatgatgatt ccaaaaagca gcacctggcc aatatgggca ccatatgcaa ctgagatagc 1769101 agttggagca ggatgcgggg gcaaaaatcc gtgagtaaca tttaaggcgg cggccatcgg 1769161 gattcccaga tacagaaaag gcatttttaa ttctttagca atcgcgtaaa caatcggtat 1769221 caacagaaca agaccgactt caaaaaatag ggcaatcccg atgataaaag aggcaaccac 1769281 aaccgccgcc tgtattcgtt tcctcccgaa tttgtcaatc agcgtaatgg cgatccggta 1769341 gccgccccca gcatctgaga caagcctccc aagcatcgcg ccaagtccaa acactaaagc 1769401 taaatgcccc agctgcccgc caattccagt ctcaattgaa agaacaattt tattgatatc 1769461 cattccaagt ccgatggcta ctaaaaatga aacgacaatc agtgagacaa aggtatttaa 1769521 ttttacttta ataatgagaa ataacagaat cagcactccg acagctacaa ttaaaatcgg 1769581 catggtaccc ctccaaaagt gttttatatg attctcgcga caatgttttg gcgcttttca 1769641 tgcctagatg aacagaaagc gctttcatta ataactaaaa acgtcttggt tatatgattg 1769701 ttatcttttg atcaactaat atgttcatac taatctccta atcaatgact gtcaatcgtt 1769761 tttatgagct tgtctcgatt acctaccgcc taacccaatg atttattagt tatatgttga 1769821 ttaacttttg gttatatgtt atgtttttta aagttgactg ccaatcatta tatctctcca 1769881 ttgtctggaa gcaaatgaga caatatgaga acagacggat aacaacttca taagaggagg 1769941 agtacacatg ccattattgc gttttgatgt aattgagggc cgtgatgaaa aatcgctgca 1770001 attgttatta gatactgctc accaagcgat ggttgaagca tttggtgttc cggaaagaga 1770061 ccgttatcaa attgtccatc agcatcccgc aaacgagctt ataatccagg atgcgggatt 1770121 agggtttcag agaaccaagg atatggtcat cattagcatg acaagcaaag caagaaccga 1770181 aagccaaaag gaaaaattgt atgctctgct tgctgaaagg ctagaaaaaa aatgcgaaat 1770241 ttcccctgac gacctcatgg tatctattac tgagaatggt gacgcagact ggagtttcgg 1770301 tctcggtgag gcgcaatttt tgaatggaaa actataagat ttcgtctccc cacaaaaaaa 1770361 agaagagaga gctccaaaga agctctctct tttttcataa atgcggaagt catcagtata 1770421 gaagcatcca gcaatacgaa aaacctggat ctccttttat atccggttta aatgccaatt 1770481 ggaagctgac tgggttttgg ctgaaaatat aaaattttgc tgatttgcat aataagatac 1770541 atcataatcc ccatttacaa taggttggat gttatagctt attgatcatt tcctatttta 1770601 tatatcccct tcatatgcac atgacatttt tgccaatccg gaaatatcag tctgacaaat 1770661 ataaaaagtc atgtaaacgg gtgtgaaccg tacttacatg actcaccatg gaaacaaagg 1770721 ctctttttca ggtgccgctt tccttatttc tcttcttcac acactgtgtc accaggctcg 1770781 caaaattgat cggcccatgc ctgcatttct tgaaatacag cttgaagcgc tgttcctttt 1770841 tcagtcagcg tgtagatgac tttgaccggc gtttcaggga gaacctgccg ttcgacaatc 1770901 tcgttttgtt caagctcctt caagcgctct gccaacattt tttggctgat catcggtatt 1770961 gtttccgtta tctctttaaa ccgtttcggc ccatccatta gcacatggat gatcagaccg 1771021 ttccatcgtt ttcccagcaa tgagaatgcg gattccattt tagggcacat cgtatttccc 1771081 ataagtcttc atcccttcat ctattgattg acatgtattc aatgatccat tacaataatc 1771141 tttcaagtta catttagtaa gcttctaact tttctattat cataccacgt ttatccgaag 1771201 gaggaaacac tatgacgaat actctggatg ttttaaaagc acgtgcatct gtaaaggaat 1771261 atgatacaaa tgccccgatc tctaaggagg agctgactga gctattagac cttgccacta 1771321 aagcgccttc tgcttggaac cttcagcatt ggcattttac agtattccac agcgatgaat 1771381 caaaagcgga gcttcttcct gtagcgtata atcaaaaaca aatcgttgag tcttctgctg 1771441 ttgttgccat tttaggcgat ttaaaggcaa atgaaaacgg tgaagaagtt tatgctgaat 1771501 tagcaagcca aggctatatt acggatgaaa tcaaacaaac attgctcggc caaatcaacg 1771561 gtgcttacca aagcgagcaa ttcgcacgtg attccgcttt cttaaatgct tctttagctg 1771621 ctatgcagct tatgattgcc gcaaaagcaa aaggttatga cacttgcgca atcggcggat 1771681 ttaacaaaga gcagttccaa aagcaatttg atatcagtga gcgctatgtt ccggttatgc 1771741 ttatttcaat cggcaaagca gtgaagcctg cgcatcaaag caaccgtctg ccgctttcaa 1771801 aagtatcaac ttggctgtaa ggatatgaaa aaccttagtc cgaaatccgg actaaggttt 1771861 ttttatacaa tcgcctcttt gtaccattca cgagcctgtt cagcttcatg ctgagtcagc 1771921 tgatggcccc cgtcctgcca gtaaacggag gctgatgccc cgctgtcacg caaatagcgg 1771981 taaagctctt ctgattcttc cttcgtgcaa agaggatcgt atttcccggc accgataaaa 1772041 acagggagcc ccgccatatc aggcagctcg ataccccgaa tcggaaccat tggatgatgc 1772101 agaatagccc cttttaacac atctttataa tgaaaaagca ggcttgccgc aatgtttgcg 1772161 ccgtttgaat aaccgactgc aatcactcgg ccgcgattaa actgatgcgt ttctgcagcc 1772221 tcgtcgataa aatctttcaa ttctcttgtc cgcaccacaa gatccttttc atcaaaaact 1772281 ccttcactca gacgtttgaa aaatcgcggc attccatttt caagcaccga tcctctgaca 1772341 ccaagcaaat gggcatcagg gtctataaac cgccccaatg aaagcagatc gtgttcatta 1772401 ccacccgtgc catgcaacag caaaagtacg ttgtcagatg ttcctttctc ataaatatgc 1772461 ttcattataa attccccctt ttaaagttca ggtaaaatgt ctgtaatttg ttgtctatgt 1772521 ttctccagcc attcaggcag ttttaaggaa gtccctagct cagcaaacgt ttcatctgtc 1772581 ataaagcccg gttcatctgt ggcaatttca aataagatac cgcctttctc cctaaaataa 1772641 actgatgtaa agtattccct gtcgagaatt tctgacgaag gcagatggtt ttcagcaata 1772701 atcggcagcc atttcgcctg ttcctttttc ttagtccgaa acgctacatg gtgtaccgta 1772761 ccatatcctc cgactcctct tttttcagga tgtaaatgga catcaatgac accgccgacc 1772821 gccgctgaag atgccagtct gacaatctgg tcttcttcgg ccactttggt gtatccaaag 1772881 ctttccgtta acaattgtat ggtcgcctgc gggtcgtagg aatatagcag cacacctttc 1772941 attcccgtaa ttgcttcatt tgttgtgatc ccgtcaggcg tccactcgct tttgccgctt 1773001 ttcgcatcct ccatgatcgc cagcggaagg tcttctgtat catcaaaaat aagacctttt 1773061 tcaccaaaca acgttttttc ctctaggctc agcccgcttt tctcaagacg ttccttccaa 1773121 aaagacaggg agcctgaggg aactgaaaag tacacccggc ccgcttggcc ttttcctacc 1773181 gttccctgtc cgcttccttg gaacggaaaa aaggtcatta ttgtaccggg atctccgttt 1773241 tgattcccaa agtaaaaatg atacgttccg ggatcatcaa agtttactgt ttttttaacg 1773301 agcctgagcc caagcacttc tgtataaaat cgcaagtttt cttgcggatc tctggcgaat 1773361 gctgtgacat ggtgcaatcc ttctgttttc attttctcac tcctatttat ctcgatttca 1773421 agatatttat tattttaaac ctttattgaa aaggatgcaa accatgtgtt ttgattaaat 1773481 aattgaaaaa atcatttttt tctaataatt atcttgtgat cttttcttac aactgctatt 1773541 atagtgagca ttatcatgtt tcaggaggaa agtaaatggt taaaaaagca cttattgtta 1773601 ttctcattct tttgccattc gttcagctcg cgcttttgcc gcttgtgaat cgaatagaac 1773661 cgattatgtt cggcctgccg tttttccact tttggctgct gctgtggatt attgttacgc 1773721 cgttatgctc gtttggcatt tatcagatgc aaaaaaaaga tggaggactt gaataatgca 1773781 agggaatctg actgcacttc tcattactgc tattattgtt ttaaccgttg tctgtatcgg 1773841 ctttctcgcc ggaagagaca aatcctcacg tacttctgtg gaagaatggt ctgtcggcgg 1773901 cagacgcttc ggcggtcttc tcgtctggtt tttagtaggc gctgaccttt atacggccta 1773961 tactttctta gggttgacca gtactgcttt tacaggcgga agtgttgcat ttttcgccat 1774021 tccttattct gtgttggcct actttatcgc ctacttcttc ttgccaaaac tttggaaagt 1774081 tgcgaaaatt cataaattaa caacactcgc ggattatgcc cgggaacgtt ttaacagtaa 1774141 gcttttggca agcctcgttg ccatcgttgg ggtactcatg cttattccgt acatatgcct 1774201 tcagctgagc ggcattcaag acacgcttca ggttgccggc actggctata ttaacgtaaa 1774261 attcgttgtg atcatttcat ttattcttgt tgctctttac acattcttca gcgggattaa 1774321 agggcccaca tatacagcca tcattaagga cattttagta tgggtcatta tgctgtttat 1774381 ggtggtgtcc ctccctctca ttcattttaa cggctggacg ccaatgattg acacgttagt 1774441 gaaggaagcg ccgcaaatgc tgacgatacc gtcagaaggg ccaaaaggca ttccttggtt 1774501 tatcacagca tctattgttt ccgctctggc actttttatg tgggcacatg ccgctacagg 1774561 tgttttcacg gcgaaaagcg ctgatgcagt aagaaaaaac agcatgtttt tgccgcttta 1774621 taatatcgtg ttaattttgg ttatttttct tggctttatc gcctttcttg ttctgccgga 1774681 agatacaaat ccaaggctgg cgctgctgca tttgattcaa acatcttacg gcggcgtggc 1774741 acaaggcttt gcatatgcca ctatcgctct tgcttcatta ataccttgtt ccattatggc 1774801 aatcggcgca tcgaatttat tcgccaacaa cctataccgg gatttgattc atccgaatgt 1774861 gtcgcaaagc aagctgactc ttgtcacacg ttcaatggtg tttgttgtca tcggtcttgc 1774921 gctgctgttt ggaatgctgt tcccgactgc cttagtgaca cttcagctat taggtgtatc 1774981 cggtatggtg caaatcttcc ctgcgattgc tgtcagcctg ttctggaaaa accaaacgaa 1775041 agaagcaacg gttatcggat tattagccgg cctagcggta acgtttattg tgtatatcac 1775101 tcaatccgca catggcattt atgaaggatt ctggggattg gccgccaaca tgatcgctgt 1775161 ggtcatcctg aatccgctgt tcgttaaaaa cgcgggatcc aatcctgtca ttgaaggttt 1775221 atttggcaaa aaacaagacg ctaatccaaa tcaaaagggc gcataaaaaa accatacgcg 1775281 gcagccgcgt atggtttttt ttacatttct tttttcagtg tttcaattgc cttttccatt 1775341 tgcgtatcat tatcagacag cttcttttga agttctatca ttaatttcgt tgttgtatcg 1775401 ccagtcagta tgcctgtttc attcagcttc tcttttttct ggaactgttt gacgacagat 1775461 acaaaatcct ggtcatacat actgttaacc tttaccttgt aaccaagtgc tttgagcatt 1775521 ttctgagcca ctttgacgtt tgtgcctgta tcacctgatt tgtacgtttt atctgcgtcc 1775581 aaatacggca gcttcgcgta atcaggcagc tctgctttca cttgaggctt gatgcctttt 1775641 ttgtgaatcc attcgccatc agcagtcagc catttggcaa ctgtcagttt gacggtagag 1775701 ccatcatcat attcttttgc cgtttgtact gtacctttgc cgaatgtcgt ctcgccgatt 1775761 aacggtacgt ttgacgattc atgaagggca gcggccataa tttcggctgc gcttgctgta 1775821 ccgtcattta ctaaaacgac ggtcggcttg gtcactttcc gttctttttc ggccttcatg 1775881 acttcttttg aaccgttttt gtattcaacc tgcatgatgt ttttcccttt atcaatgaac 1775941 aggttgctca tcgtaatcgc ctgttccatt aagccgcccg ggttgcctct caagtctaaa 1776001 atatagcctt tggcgccttt tttctctaaa ctgtcaatcg catctgtcag ctctttagct 1776061 gttgtttcag agaaagaagt gatttgaatt tctccgatgt tgttgtcttt catctctgaa 1776121 tagacagtct ctacaggaat ggtatcgcgc ttaatggaaa gatcgatatt ccccactccc 1776181 gctctgttca gttcaagctt cacctttgtg ccctttttgc ctcggattaa agcgacggct 1776241 tcatttacat tcatgccttt tacgcttttt ccatttacct taatgatttg gtccctcggt 1776301 ttgataccgg ctttttcagc aggtgaacct ttaattgggg atacaataag gatttctccg 1776361 tctttctcct ctacttgggc tccgattcct tcaaaagatg ctgaaatcgt ctcgtcgaat 1776421 gatttcgctt gctcttgatc catatatgta gaatacggat catccagtga ttgaatcatt 1776481 cctttaattg ctccgtctac taatttgtca tcatctgttt tttggtaata atcacttttg 1776541 atttgctcat acgctttatt taatttgtcg aacttgctgt ctcctgtgct tgctgatttt 1776601 tggcccagga tactggaatt gcccgtaata aataaagtaa gcgccgaagc gacaactgca 1776661 gtgatcagca caataaaaaa cagttttaat tgccgtttca attaaacacc acctttttct 1776721 tcttacatta ttatcatgga cgaattctta ttcgtcaact cggagcagaa atgaaagaga 1776781 aacgcccttc ttttgctttt cataaaccta tgtctttata cgacatatga taaggaaaaa 1776841 ggaggattcg atattgagcc gatatttaga aatgctgtcc ttattcggtg tcgcaggggc 1776901 gcacccaggc gggctggctt tttcaaaagc ggtcttgcaa aaggctgcac cctctccgga 1776961 tcagccgatt cttgatgccg gatgcggaac agggcaaacg gcggcttatt taggacattt 1777021 gctgtatcct gtaacagtcg ttgataaaga tcctattatg cttgagaaag cgaaaaaaag 1777081 atttgcgaat gaagggcttg ccatccctgc atatcaggcg gagctggaac atctcccgtt 1777141 ttcttctgag tccttttcct gcgtcctgtc agaatcggtc ctcagttttt cacgcctgac 1777201 atcctctctt caagaaattt caagagtttt aaaacccagc gggatgctga ttggtatcga 1777261 agctgcttta aaaaaaccaa tgccccctgc agaaaagaag caaatgatgg atttttacgg 1777321 atttacttgc ttacatgaag aaagcgaatg gcataaactc ctaagatcct atggctttca 1777381 aaaaacagaa gcgatgtcac ttcttccgga agacatggaa tttgaaccaa ccacagaaat 1777441 ggatttatcg caaacgattg atcccatcta ttacgatacg cttcaaacac attatcagct 1777501 catgcagtta tatagtgagt acatgggtca ttgtattttt atcgcgtaca agtaaaacgg 1777561 cgtatcgccc cctgttttcg tccaaccttt ttttcctatc tatcatatgc tgatagaaag 1777621 tcaggatagg aggggaacaa tattggagag atattatcat ctttgcaaaa accatcaagg 1777681 taaagtcgtc agaattacag agagaggcgg gagagttcac gtcggcagaa ttacccgtgt 1777741 aacaagagac agagttttta tagctccggt cggcggaggg ccaagaggtt tcggttacgg 1777801 atattggggc ggttattggg gatatggagc ggcttacggg atttccctcg gtttaattgc 1777861 aggagtggct ctggctggtt tattcttctg gtaagcatag aacaaatgct agattcacca 1777921 gacacaatga agcccgctta tctagtgtaa gcgggctttt cattttaaat tttcttcact 1777981 ttttcaaagt actcttcaag cgttaaatca ttatcttgga tgacctttgc ggcttttttg 1778041 cctacatagc gcagatgcca tggctcatat tcatatttcg tgatatcttc tttatttttc 1778101 ggatagcgaa taataaagcc atatttataa gcattgtcct gcacccattt cccgtctgcc 1778161 gtgcttccga acgcttcatt tagctcaaag ccattgctcc ggctcgaaat gtccatcgca 1778221 aggcctgttt gatgctcgct ttcacccggg taagcgaccg cttcctttgc cttcctttcc 1778281 ccttttaggc ttacttcatt gtcaaaaatg actttctgtc tgtcatacga acggtaccct 1778341 gagacagctg ccagttcata gccttccttt ttggcagcat cgaacattgt ttttaatgcg 1778401 tcggccgctt cttttctgat gtaacgtttt tgaatctttt cttcaaaaga aaactctaca 1778461 tcaggtatga caagatcgct aggttcatag tttccgggca gtgcatattg tttattgaca 1778521 agcgcgagta tattttctgg attttgaatg gtttccagac catcgacttt tttaatatca 1778581 ttgaaatact ggctttccaa tgaaaactca ctgttttgag tgtttgattt tttgctgtca 1778641 gctgtttttt gttctgtttg ctttgtttct gctgtggttt tcgtatcctt ttgagcatct 1778701 ccgttcgaca tgctgcagcc ggctccgact attgccgtta cactcagagc ggcagccagt 1778761 gagaaccatt taccggactt tttcatatta cattaccttc cttttatcaa tcgtttccgc 1778821 atgcataaag aagaggctgc cggcacccag cacgcctctt gatatatttt attgtgatac 1778881 ggaatgtaaa gccacttcta tcatatcatg aaatgtcgtt tgacgctctt ccgctgtcgt 1778941 ttcttctcct gttaatacgt gatcactcac ggtgagaatt gacagggctt ttcttccgtg 1779001 cttcgctgct aatgtataca atgcagttgt ttccatttca acgccaagca caccgtattt 1779061 tgcaagtttt tcaatttgcg aatcgtcatt gtagaactgg tcagctgtaa atacgcttcc 1779121 tacagtcacc ggcacacctt tatcctttgc ggcatcatag gcatttttta aaagctcgaa 1779181 atctgcgcaa ggcgcaaaat caacgcttcc gaaagcaact ctgttcattt gtgaatcagt 1779241 tgaggaggtc atcgccaaaa tgacgtctcg cactttgaca tctttacgaa tagcgccgca 1779301 ggaaccgact cttattagat tttgcacatc gtagctttga attaattcat tcacataaat 1779361 tgaaatagac ggaactccca ttcccgtgcc ttgtactgag atttttttac ctttatatgt 1779421 acccgtaaat ccatacatgc ctctgacttc attgtagcat tctacatttt caagatacgt 1779481 ttctgcaata aattttgctc tgagaggatc tcccggcaaa agcacagtat ccgcaatttg 1779541 tcctttttca gcacctatat gtacactcat ctcatatcct cctgtaaatc taaattatca 1779601 tccagcccgt ccattttaca acgaatgtca tgatgaaaca aacttcagca ttgattataa 1779661 aggaatatat cgaaaaaaga aatgttcgag gatctgttag gcacttcctc agaaaaacgg 1779721 ataatcgggg tgttaatttg aaaacctaac cgcaggaagg aggggtggga catgggtaaa 1779781 aaacatcgta accggatcac cggccaaaaa aagaacaatc atatacctga aaaagatatc 1779841 attgcagctg aagaagcaca cgggaaagaa tattccgctg ccaaacgcaa gccttaaaac 1779901 tgcagaaaac tgcgggtttc cgcagttttc ttttcattat gtcgtttgta caatcagacg 1779961 attgattttc ctccagccgg cgggaagcag ttgataatat gttttccctt ttctgccttc 1780021 atcaatcagg atcacgtccc ctgtggccat gaatcttgca tcataatcac tcggaacagt 1780081 gtcgaataca ttaaacaaag agaatgctct tttcagcacg tcttgatgat cgctcccgtt 1780141 cagttcagtt cgatagacgg ctctgtagcc ctttttttcg ccaaaccggg gtgtctgaaa 1780201 tattgtcacg tcataggaac aagacttctt tttaaacacg gataacatca tcaagatccc 1780261 ctccctttta tttctttaac atattggcgt ttttgctgtg ttttcctctc tctatttttg 1780321 tcgaaaccgc ttaatctttt cgtcaaaacc ttttactagg aaaaacagaa gcaagccgag 1780381 gctaaagcct cctaacacgt ctgtcacaaa atgaaccccc agatacactc tgcttatgcc 1780441 gactaaaaca gcaattacac cggctatgat atataccatt tttttatgct tagacaaaaa 1780501 cgggagatgt ttcactaaaa agtaagcaat aacaggatag acacaagcag cattcatgga 1780561 atggccgctc ggaaaactga aggatgattc atgaaccagc ggtgcaaaat caggcctcac 1780621 tctttcgatc cattctttta agactttgtt taacagccga tctgtgccga atactaagag 1780681 catcaacagg ccgtcccatg tttttctgta gaaaaacatg cctgctccaa tgatgacaat 1780741 tagagggagc agaaaagaag aagcaccaag atgcgtgatc cccgtcatga cttcattaag 1780801 ccatggctga cggatcaaaa cagctgcctt gcttattgct tcatctgcag attgaacagc 1780861 atttgtatga atggccgcag ctagaattaa aaagaaaaga aacaaactaa cgggcttgta 1780921 caattttaac cacctcaatt ttcacagaag tcatagaaca tgaataataa aaccggagct 1780981 gaccgctccg gttttaagcc tcactcatct tcatccagct cttcatctat catacatttt 1781041 tctatcaaat aatcaaaggt aatatcagcg atttcaaaca gctcatcctc actcggtatg 1781101 tagccccgtc ttgcaagctc tctgtaaaaa aattcagcga tttcttccgt atcaatcaca 1781161 agatctattt ctttcatctc cgtaccgcct ccttttttat gttttatgaa aaaacaggct 1781221 gaattatacc cggtgttcta aacaattctt tcagtcatat attgaataaa aaacgagcca 1781281 tgggaggctg acgctatgat tgctaaaatg atggaagcac tggacggaga aagatttgat 1781341 atcataatgg aaaaaacgct caaaggaatg acgcgtgtga tgatttgggg ctgtctgcca 1781401 tattttttat atgtcttgat ccgtatgttc acaaattaac tgaaatgctc ttttaaactt 1781461 tccaaaacaa acatcatcat gtctttatat tcttcatcct gaaacatttc gtacagaatt 1781521 ttgtagtcat tataaatatc cagaagctca tcaacaattg acacagcaag gatgtgaagg 1781581 gtatcttgat cttcatcacc gccttcaaac tgaagaagag cagacgatgc gatatcttcg 1781641 ccgatctcat ggccagtttc tccgacataa tggacaaaca acagctgatg cacaaactgg 1781701 tccatttcat attttctaag caccagcgtg agatcctctt cctccgtttc aagccactct 1781761 ccatccttta aacgggtcag ctcataaatg atatcttccc agccatcttc taaatatctc 1781821 caaatttctg ttctatggcc gataatgcga aagagttctt ttccataatc tttaacataa 1781881 acaacgtccc caataaggaa ttcatactca atatcaagct tctccatgtc gacaatgaca 1781941 ccctcataat ctttataaag ctgaatagat gattcaaagt ataaaacttc gttatgattg 1782001 acttcataaa gatagtgttt atcaatttgg tgtacttttg tgatggtgcc gactgttcca 1782061 tacataatga cgactacgat atcccctact tggaatttcg gtttattttg cttcatggtg 1782121 tctccccctc gccgcaacat ttctcatacg ctatcgtatg ccgggtgaag ccaattcgca 1782181 tgggcatgaa aaccaaagga aatatccaat tatggtatgg gtatggacat aaaaaaatcc 1782241 gcagtgatct gcggatgaaa cagctattat ctgccgtgca cttcagactc gtattgatcc 1782301 caagcttcat caaacgtcgc catcgtgtga aggtaatcag cattcagctc caaatatgaa 1782361 ctgatttcat gataatcggt tgatgttttt ggaaagctgt gatcctcata cgcctgattg 1782421 gcaaattcac tgatgctgtc cttcggctta gggtgtctgt atttcaataa atagtgataa 1782481 aaggatttca tgggtttccc ctcctgatgt ctgtcttttg ttgttctatt atacagttca 1782541 agtgtaaaat tacaacaaaa gaatactgaa acatgactca ggagaagtca aaatagttgc 1782601 gtttcaaaat tctttctgtc tccatgagct gctgatatgt caggctttca ggcagttttt 1782661 ttgtttgaat taaaagcagc tgatcctcaa tctctttaac cgtgttttcc tcttgatagg 1782721 tcataccgca ggaagaacat accatggcag gggtgtctgt cagttctata gccctcgttc 1782781 catcagggag ctcccagtac accgtgttcc tgccgggcac cgcttcgagc tcgccgcacc 1782841 attcgcatgt tttcatgaag aatcccctcc gcattcagtc tctttctgtt ttttctgctg 1782901 cgccaaaaat ttcttttctt tgagctgatc tcttttctca cgccgatctt ttaatgtttc 1782961 atgctccgga tttgcgatgt atgcctctct ccttttgatt ctgtctacat tttcaggtgt 1783021 aaacgaaact tctttgtcag caaaaatggc actcagcccg atcggctcct ttttgtcagc 1783081 ggtttcaggg aaaacggact caaaataggc gtctgcctga ttggggatat aattctctgg 1783141 ttccggatat gacgtaatca caccttcaaa atttcttaag atcactttgt caggactttg 1783201 tgacaggaca tagtttggct gcagggcgat tttacctcct ccgcctggtg cgtcaacgac 1783261 aaaggtagga accgcatagc ctgaggtatg acctctcagc ccttcaatga tctccaaacc 1783321 tttggaaaca ggagctctga aatgccctat tccttctgac agatcacatt ggtaaatata 1783381 ataaggacgg actctgattt ttaccaagtc atgcatgagc tttttcataa ttggaaccga 1783441 atcattaata cctgctaata cgacagcctg atttccgacc ggcactcccg cgttcaccag 1783501 cttttcacat gcctcaacgg attcttctgt catttcgatg cttgtgttaa aatgggtgtt 1783561 cagccagacc ggatgatatt ttttcaatat ctcgcacaga tgatcggtaa tgcgctgcgg 1783621 aaagacgacg ggagctcttg ttccgattct gatgacttcc agatgcggaa tgctgcgcag 1783681 ctcttttaaa atatattcta aaatttggtc gttgatgagc agcccatcac cgcctgaaat 1783741 taaacaatcg cggatttcgg gtgtttcccg gatataagca attgcagcat caagctgttt 1783801 tttggggacg cccattccga tttgtccgga aaagcgcctt cttgtgcagt agcggcagta 1783861 catggaacat tgattcgtga caagaaacag cacacggtcg ggatagcggt gtgtcagacc 1783921 gggtaccggt gaatcttcat cctcatgaag cgggtcttcc agatcgtatt ttgttttgtg 1783981 catttcttca gaaagcggca cagactgcat gcgtaccggg catctcggat tgtcggggtc 1784041 cattaaagaa gcatagtaag gtgtaatatt taaggggatc gttttggtag aaattctgac 1784101 gccttcctct tcatcctcgg tcagattaat gactttcttt aaatcatcta acgttcttac 1784161 agtgtgtgtc agctgccaaa gccaatcgtt ccatttctct tccggaacgt ccttccataa 1784221 ctcgatctcc ttccaatgcc gtttcggttt ataccatttg tttttcaaac gaactcctcc 1784281 tcgcgcatat tttgacttac agttgcttgc accaaatatt catgttttca aggccttcgg 1784341 ctataaagca attattgatc agccttccgc catactgata acctgaatgg tacaacacag 1784401 cattcatccc aaaagacgaa gcacgggcga gagaaaacac atgaacgata tcctctccag 1784461 ccatttcttt ttctaacgcc tcgattaaaa agcttgttaa cgaatggccg cgatattccg 1784521 gcagcacagc gcaatcggtt atttctgcat gcccaagctc tggattgatt tctgcgcttg 1784581 ctgcgctgat caggcggtca tgatcaagca tgatataata caccgtattt gcattcatcg 1784641 tcttttcaat ataagcgggg tcaaataccg gggttgggta cgtgcggaat acttttttat 1784701 acagcatcga tagctggtac atgtcgtttg tttctgcttt tctcatcgta aaaacgggtg 1784761 tactgtcgtt gcgaagacgg ggcgctgtgc gatatatggc ttcgatgatc tcctgttcct 1784821 ctgtataaga atctgtttgt ctccggcttt ctgaaaggta acgtaccatg acacaagccg 1784881 aatggccgag ataatagccc tttagatagc cctccggcgc aaataattgt ttggcaagga 1784941 tcggctcatc atgctgcttc gcatagacaa tgattttttc tgcattctct tcttttgccg 1785001 ctgccacgat atccggcagg gccttctcaa tggctccgtc ataacgaacc actctgattc 1785061 gtttattaaa gccgtcatgg tccaaaactg ctgtgacacc gctactcttt attgacttga 1785121 gcatccgcat cctccccatc tgtatgaagg ccgcaccaat ccatgacaaa aagtgcaata 1785181 attttagcag attctatcat ggcttcaacc tcaatgtatt cattggcctg atgagccgtt 1785241 tttgtttccc ccggcccgaa aacgatcact ggtgtatctc ctgcatggta caaaagccct 1785301 ccatccgttc cccacgggga agcctcaata atcggctctg tctgtttcat tttttgatag 1785361 gctgattgca gcacagaaat taaagggtga tcatcaggta aatcattcgg cagccattga 1785421 gcgccaaacc attcgacttg tacgggatgg cgtttaaacc attcgtcatg gtattctaaa 1785481 tccttcagcc agttttccaa ttcaagtttt acagcttctg gtttctcatg gggagcaatt 1785541 ccgcatctcc cttctatgac gacacggtct gcaactgaag atggccaggc accgcctgag 1785601 atggtgccga tattcaccgg taccggtatt gggatattgt catacagcgg atctgaaatt 1785661 ctcgcattgc ggactttctc cagctcttgt atcgctgtga taacgtgcat gcttttttca 1785721 atcgcgctta ccccttcata gcgtgtgccc ccatgtgcgg ataatccctt cacagtgatc 1785781 cgaaaccaca tcgaaccctg ctgcttaata aatagtttca tattcgtcgg ttcaggaatc 1785841 agcgccccgt cagcacgata gcctctcatg atggcggaaa gtgtaccggc gccgccgcac 1785901 tcttcatcta caacactctg aaacaataca tctcccttca gtttgacatc gcaggcgtgc 1785961 agggcttcta aagcaaaaag aagggctgta ttgcctccct tcatatccgt tgagccgcgg 1786021 ccgtatattt taccgttttc ttcgacagct tgatacggtt catacttcca atcctttacg 1786081 cttccttcag gcacaacatc gatatggccg ttcaaaatca gggacctgcc tccgccggct 1786141 cccgtttttt tagccacgat attcgggctc tcatgaaaat cggatcggtt agatttaaag 1786201 tagggatgct gttttaattg ctttatgctt ggctcccata catcaatgtc catatgaaat 1786261 tgccgcagct tttcaagcac aacagcttgg gcgttaaact ctgaccccaa tgtgcttttt 1786321 tccccaatca gccttttgag aagacgaatg gctttggccg aatgctgatc aagccactcg 1786381 attacttttc tttcaatgtc ttgcatcctc attccccctc ttaagaaaaa ggcatatcta 1786441 ttttgatttc agcttctgtc agcctcgtca cctcatcgat tgtcgagcca ttcatcagct 1786501 cttttaaaat gaagtgatgg ctatcgacct caagaaccgc tttttcggta ataatcaaat 1786561 ctacacagcc tgcagcagtt aatggcagcg tacatctttc tgttaattta ggccttccct 1786621 tttgatctgt atgactcatg acgacaacca cttttttcgc tttttgggca agctccatcg 1786681 ccccgcccat accaggcacc ttttttcccg gaacaagcca atttgccaaa tctcctgatt 1786741 ggctcacctg cagggcgcct aaaatcgtaa tgtcaatttt gccttttctg atcatcgcaa 1786801 aagacatggt tgtatcaaaa taagaagccc cttttacagc gcggacagga tatcccgcgg 1786861 cgttgcataa atgcgcatcc tcttctccct tttcgggact ttctccaatg ccaaggacac 1786921 cgttttccgc ttgaaacatg acctgcatgt caggcttcaa aaagttcggt accaaggaag 1786981 ggataccgat accgagattc acaatcatgc cctgcttaat ttcagtagca gcgcgttttg 1787041 caatctgttc tctttctgct actcccaagc ccatttccac ttcactccct cgcttcgtac 1787101 aaccccctca acaaaaaccc ccggtgtgac aatcatttct tcagaaatct cccccatcgg 1787161 aacgatacgc tcagcttcgg caaaggttct cctggcggcc attgccataa gcgggttcat 1787221 attgcgcgcg gttttgtcat acgttagatt gccgaattca tctgcaatgt aagcattgat 1787281 gaaagcaaaa tcagcagtca gcgcctcttc aatcaagtat cgttttcccg ccactgttac 1787341 gatgtccttt ttttcgcaaa ccatttgatt atcaatgccc acgtcggtta aaataccgcc 1787401 aagccccgct ccgccggcgc gaatccgttc cgcaagcgtt ccctgaggtg aaaattgaac 1787461 ctctaacgtc ccctctgtca tctgttttcc ggctactgga ttggaaccga tatgcgaggc 1787521 gatcagggtt ttgacccgtt gattaacaat aagcgggccg attccgatat ccgggaaacc 1787581 ggcgtcattg caaatcacag tcaaatccgt tacaccgctg tccaatatcg cttcaatcaa 1787641 tgaaggaggc gacccgactc ccccaaaacc gccaaacatc agaaccgatc catcccgaac 1787701 atctgcaatt gctgtgtcaa tgctgattgc tttttgaaat ggcgccattt aatgtcaatc 1787761 cttttttaag tttttttcga ccgctgcaac tgtttctgaa aaaatagaga taagctcttc 1787821 catttcaccg tctgaaatag taaaaggagg agcaataatg acagcatctc cttctccact 1787881 gtctattcca gctttggaag gataaacaat cagcccgcgt tttttcgcct cgctgacaat 1787941 aagctgggtt atcgcctgct ctggcggaaa cactttcttc gttttttggt ctgccacaaa 1788001 ttcaatgcct aatagcagtc cttttccgcg cacctcacct ataatgccgc tttgagatgc 1788061 cgcctcatca agcttcttct tcagcacagc gccctttttt tctgattgtt tgatcaagcc 1788121 gtgctttaac acatatcgca aaacttcaag agcagctttg gctgaatagg gatgtgcact 1788181 atatgtgtga ccgctcataa tcacacctga cccttgtttt atggtttcaa taatagaatc 1788241 agatacgacg gcagcagcaa taggtgcata ccccgcaccg agtcccttcc ccagtacagc 1788301 aatatcaggt acggtatccc aatgctctgt cgcgagcatc cttcctgttc tcccaagccc 1788361 cgtcatcact tcatctgcaa taaaaagcac atcgtgtgtg cggcatacct cacttaatct 1788421 ctcataatat cccggaggcg gagtaatcgc tgctcctgca gcaccaataa taggctcagc 1788481 cacaaagccg gcgatgaatt ggcttccgat tcttttaatc atggtgtcca gttcatcagc 1788541 tgcagtctga acaaagtctt cttccgtctc gtgattcagc cgataaatat gtggagctga 1788601 gatagctgga taccgctcaa tgagatgggt gaaccggtat ctcctttcat aaaaaccaga 1788661 caatgaaagc gctcccaaag ttattccgtg gtaactgctc catcgagaca aaaagatgga 1788721 tttttgtgtt tgcttttttt cctgccaata ctgaatggcg attttcatag ctgtttctat 1788781 cgcttctgat ccgctgttga caaaaaaaga ccaattcaca tctccgggca gctcctgtgc 1788841 caagagagcg gctaattgct cggcgggctc actcgtaaac tgtgagcggt aagcaaaaga 1788901 cacctgatca agctgttctt tcagcttctc agtcacatca cgaactccgt ggccgatatt 1788961 acatgtcacc gcacctgacg agccgtcgag atattttttt ccggtctgat cataaacata 1789021 tgaacccttc gcataactga caaccggata ggccgagcta agctctggct taatcaaata 1789081 actgctcatg ctcccacctc aaaacccctt ttaccatatt gtatgagtgt ccaaatggcg 1789141 gcatgacgtt ccccgcaaaa actttttcac ataaaaagag ccttcctaat aaggaaggct 1789201 cttttgaaat ttcagcatct agcaaataaa agcggctcca acaataatta ataaaatgaa 1789261 caagacaaca attaacacaa atgtatttgt cccgcagcca aatccgtaac cgtacccaga 1789321 gtatccatac atgctgtttt catcctttct tatcacgata tacgacattt tatgcgggcc 1789381 aagtcccaaa tggtttgtgc aaacgcctat ttcatgtaag gaaataatga aatacagtat 1789441 gcacccgctc atatttttta aacgtcagct tttcgtaaaa ctgagttgca ccgtcagtgc 1789501 ttgcagccac taagtaggct gcttccattc ctagtgattt ggcgatggac agcatttctt 1789561 tcactaagat actgccgtag cccttccttt gaaactgatc taaaattgcc acttcttcga 1789621 ttttagccgt tttctcttga tgatcgataa acagctcgcc gcacccaatg ggaactttct 1789681 gtgcctggtc gctgtaacaa acaacaagaa tgattatatc tgcttcatag aaaggatatt 1789741 ttctttttaa tttttgttca gcgattgctt ctccaatata aatggaatcg taaattttca 1789801 taatagaaga tccgtcgcta agactttttg ccgtccccca tgcggttaaa ggatgtccca 1789861 tctgcccctt ccagtcacta agcttcatgt catatagtag ctcatcctcg acgacaaaac 1789921 cgctttttac aagtgactgc ttcaaaccga gcggaaaaac atgctgcggc gacgctttta 1789981 aatggagata attcgcatca agcagctttg gtacggaggg taaaaagtta agtaaccgct 1790041 ccaatggaaa cgtatcatgg agctgaacaa agttatgaga aaaaatttgc ggaagctgcg 1790101 gatctctgta tacgctgtaa tgatcaaacg atgccgattc agacgttaac aatatatatt 1790161 gatgttccgt ttttgaataa tgtcctgtca tgaacgtctc ctttttatga cctatacctt 1790221 tactctgttg caatattcaa tttctttata atctcatcgt acaccggata aaacggcttt 1790281 ccaattggaa attgctgaat atttcggaaa gaagcggaga ttggcttctg atgtaaaaaa 1790341 aacttccttg ttacttgttc actaatcggg tgaaagacgc cgtttagaaa caaaaacggc 1790401 tcgcgttcga tgaaaaacag acgtcggcca ggcggatttt tgatcaattc agatcgtttc 1790461 cacgtaatcg gcggcccttc cggaagcgtc tccatctctt cttttccaat tgtcactatg 1790521 tcttttcttt gaaattgata aaattgaaac gcatactggt ccacaattcg cctttttttt 1790581 ccggcttcga tataaaatat tgcaggatgg tcagcttcct ttactaaaat ataattcgga 1790641 atgtttaaaa ttttgccaat cctatattgg aataaatatg ggtctggaac agcgacagtc 1790701 cgatttagat acaaaaaacc ccacttttct ccaacaggat gccttacacc ctgatcaaaa 1790761 aaatacacat tttgatctga accttttaca aaagagccgt caatcaaatc ggcgggcaga 1790821 aaccgatatg cattttgaaa tgaatctggg gttttatagg ttgtgtctaa tacttcattt 1790881 atcggcagaa atggggtaaa gttgttgagt ctcgcccaaa aaattgcgtc gccatgattc 1790941 caatgcttca tatcatcatc ccagtagcct ccaaatttat ggtgaatgag attaagtaac 1791001 gaacggcgat gcataactga gcaatgatca acttgaaaag cggcctgatc aagcactgca 1791061 ttggcatttc tgtagaaatg tgagatttcc tctccccttt cgtttacatg tacaactttt 1791121 tgttttgaat agaccgcctg cgcttcaggc ttatgtgaaa actcttgcac catacggctc 1791181 agccgctcag gatgataaac agtgtcgtca gtaagatagg aaatgtaatc gccgtctgca 1791241 aatgggagcg cactgttaat taatgtggca taacgggctg tttttaatcg atctgcagga 1791301 tgcacgaaac tgttatgata ttgaatgcgc cggtcatgga gatacttgtg aatcaccgca 1791361 gttgtttctg cattcgaatg atcatccatg ataaaaagct cccaaagatc atgcgtttgc 1791421 tgtatcacgc tttcgatcgc tttttgcaaa taatcgggtt tgttgtaact tgttaaaata 1791481 atagacactt tctctcccat ctataccgcc tcccgccgtc aaacataaaa acggctccgc 1791541 agcaagcaga gcctctgtca tcatttaaaa agcaccccag cttacaacac ttgagagtga 1791601 aacatgagat ctcgtgttat ttaacgggtt ttggaaaata accaaatcag tcagaacttc 1791661 ttttacgatg acattttgaa gtgtatctcc gttgatcaaa ttgacttttg aaaccggtac 1791721 gcccagctct tttgcaaaaa caagctggcg tctgaggtca gatggatttc cttcagaaga 1791781 cgattgacgt atcagcagaa tcagcaaaag caaaataaaa tgcagatcat cttggttttc 1791841 ttctcgatcc acttgtttct ctaaatccaa atcatccctc tcccttatcc ttatctctgt 1791901 ttcacaatat gtgcgacttc gatttatggt ataggctatg tccactccat taaaaaatca 1791961 gcattttcct taaatagatg aaaaatagat caggtacggc gttcgactca taccaaataa 1792021 cagccggaag aatatgaata acgtgagttc actatcgaat aggaggtgtg tgtaatgagc 1792081 tctgaaaatg cacagttaaa aaaggattta attaaagccg ttttaagccc tttatttcca 1792141 actgcaacag aaggaggaga aaatatggat agtaatctta aagccttgct tgatgctgcc 1792201 atcgatcaaa aagtagatga aagtgaaacg gttacggcag aatctatttt agacccttct 1792261 cttccggcaa gatggatttt tgccagaatt acgccaggca ctacaatcag cattgtgact 1792321 gattcaggtg acatgatcgg accggttgtt ttcgttgctt tcgatcaggt tcacgggatc 1792381 gtatttgtaa cacaggaaag ctccgtcact ccggcaggcc aagctacaac attaattgat 1792441 gtagacaaag tagaaagcgt tacgttcttt tcataacatc cgatgaaagt cttgtatatc 1792501 cagtcgggat acggaggaat atacagttat tttgatcgct gggctgaaga atgttttcag 1792561 aacactcata cagagtatat gattgcagat aaacctgaag cagaatcttt gatgaagatc 1792621 gaagcgtttc agccggattt cacacttatg atggttggag accgcgttcc tcacgactgg 1792681 ctgacctggt taaagggtaa ggatatcccc gtgtatgttt ggctgaccga agacccattt 1792741 tatatggata tcagccttca ggtaattaag cttgctgacg ccatattaac gatagaacaa 1792801 aatgcagctc tctactatca agagctcggc taccagaacg tctattatgt tccgatacca 1792861 gttaaccatc ggctgtttaa aaaaatgggc accgaacatt cctatcattc aaatctgtta 1792921 atcatcggct atccttaccc taatcgggtt cagcttatga aagaagcggt ccatctgcca 1792981 ttcacggttc gggtaatcgg caaggaatgg ggaaaatatc tgcctaaaaa agtgctcaaa 1793041 cagccgcata ttgatgtcgt cagcacatgg gttccacccg aacaggccgt tcattattat 1793101 aatggggcag acatcgtaat taatgcgcat cgtccctatc attttgcttt caaccaaaat 1793161 actatgcgca tcaaaaatgc cagttttaat aaccgaacgt ttgatatcgc tgcatgcgaa 1793221 gcatttcaat taacagattt acccgcggcg catccttttt catccattat ttcttatcac 1793281 ggcatgaacg actttaagga aaaagccgct ttctatatca accaccctga agaacggcaa 1793341 aaagctgcag cagccaatta taaagagacc gtacccgcat ttacgtttga tgagcttcct 1793401 gcaaaactaa aagcgattca tctggcgctt tcttgaaaaa tcgttcattg ctatgaacga 1793461 tttttttatt catagaaaaa agcagctgca caagctgctt tctattctag ccgtcagaac 1793521 ggtctttcag cttcctcgga tttacctgtt tatgaagatc aggcatttcg ccgagatgct 1793581 gtgcaatttg ttcccacgat acaattttga aattttgatt gacggcttgt ccgttatcaa 1793641 tattttcgcc gtcctgcgcc acaaaaatcc cgtacggata ttttgggcca agtccgaaac 1793701 cgagaacatc aataccatcc gtgtcactag taccgtctat cttctcgcca tctgtaatct 1793761 caaagttggc tacatagcga tttttcccct gccgttcata cattgcatag ctgttatttc 1793821 cttgacttga agccatgaga tatcctttgc catttggtgc ataatagatt gtcagtcctt 1793881 caatatcagc tgtcaaatga tctcctgtcg cacggtcaac aacctgcccc tttgaccctc 1793941 cgccgggctc agcgttaaat ttccagatgg cctcatcttc ctctgctatg tataggtttc 1794001 cgtactcatc atccgcaaca aggccttcgg tctgagaatt caacttaaat tcacgcacct 1794061 ttttccctgt tacataaccc tttccaccat caacaatttc atactgctca aattcccctt 1794121 gtttgcctgt cactaatgcg taaaatgctc ctgttttctg gctgtgatac aagctgaatc 1794181 cataaacctc agaaatattg gtggaaatag gatggttcgg atctgtaatg cttttcaatt 1794241 ttcctttatc cccgtctatt gcatatactt caattgtatt ttttccttcg gaccggttgg 1794301 atgcggcagc aatatcaatt ttttcgccgt tcaatggaaa atcatagcgc agatcgacat 1794361 tattgagctt gccaaactca taagaatgaa gctgttttcc gtctaaatca tacacaacga 1794421 gccctgactt cttatttgtt gtaatcaact tgcttttttc cgggtgtttt tcatgaaccc 1794481 aaatggccgg gtcatctgct gcatcatcgc cagatgcgac cggatctgtc tccgtgtgtg 1794541 cagtcacttt gaaatgatgt tcctcattca cataatgagc cgacaccgag gttgctgtca 1794601 ggctaagcaa taaacccgcg gcagtgctta gcagcattgt ttttggaacc ttcatttggt 1794661 accctcctct tttatcacta acactactat tgtaaaatat atacaggtga ttaccgtgag 1794721 gaaaatgaac ctttttttat agggtttctg actcataaac aacttattcc ccaaagaggt 1794781 ggtgagatga ctttgccaga tttacttttg cggagcgaaa taaaaatatg ttgaatattt 1794841 agtacattat ttatttagtt ttgtttttcc ctagttacgt ccgtttttcc attttctatt 1794901 aaaaaagaac actttgtgac atgatcattc ccctaaattt tgttttattg gttgctttca 1794961 ttaattcgat tacaaagttg aacatatgat gcatggtaga gaaacgagag ttggaggata 1795021 agccatgcct aaacagcaaa cagcagaact aaaaccattt ttccataaca aaacagtttt 1795081 agtcactggc ggaacgggtt caatcgggag tcaaattgtc aaacgccttt tgatgcttac 1795141 acctaaacag gtgattgtat tcagcaaaga cgacagtaaa cagtatgtca tgagccaaaa 1795201 gtatgcggag gataagcggc tattatttgt acttggagat gtacgcgatc acagaagggt 1795261 gaatcaggtg atgaaaggcg tcgatatcgt ctttcacgcg gctgcgctga aacaggttcc 1795321 gacatgtgag gaccatccat ttgaagcgat ccagaccaat ctcatcggcg gacaaaatgt 1795381 ggtggaagct gccctttcac accgagtgca gcatgtcatt aatatcagta cagataaagc 1795441 tgtatctcct gtgaacacaa tgggtgccac caagctgtta tctgaaaagc tgtttcatca 1795501 agcaaaccgc cacgtccaaa acaaaggaac cttgttttgt tcggtccgct ttggaaatgt 1795561 tctcggttcc agaggttcgg tcatccccat attatttgaa cagatgatgg agggtgaacc 1795621 tctgaccatc acagacaaaa acatgaccag atttttcatg tcaatagacg atgcagctac 1795681 attgacatta caatcggctg ctattacaaa aggcggagaa acctttattt tcaaaatgga 1795741 atcactgaaa cttgaagaac tgattcatgg gtttgaagaa tatgcatcgc agcacgggct 1795801 cccgcggccg gctgcagtag aagtgggcaa gcgtccaggt gaaaagcttc acgaagaatt 1795861 aacatctcca catgaaattg aatcactgta tgaatggggc aacctttatg cgatccttcc 1795921 agagccggaa aaacatcctg actttcgcaa agtcaatctg cctgggtatc aatcagatca 1795981 agccccgctc attacgaaag aaagaattgc tcagattatt gaagaattgc atcaagagaa 1796041 aaaggcataa aaacaagcct gtctatccat taggcaggcc tgtttttaac agtttattta 1796101 ttaaagagat gcagatagct ttcgtatcct tcttctttta gcttatgctt cggaacaaac 1796161 cgcagcgctg ctgaatttat gcagtaacga agtccgtttg gccccggtcc gtcattaaat 1796221 acgtggccaa gatgagaatc agcagttcgg cttcttactt ctgtgcgaat catgccgtgg 1796281 ctcgtgtcca gtttttcttc cacttcttct tcaatcggct ttgtaaagct tggccagccg 1796341 cattgggaat caaatttatc tttggatgta aacaatggct tgcctgacac aatgtctaca 1796401 tacaaccctt cttccttatg atcccaatat tcattttgaa atggcggctc cgtgccgtta 1796461 ttttgcgtta cttcatattg catgcgattt aatgacttta ttttttcttc tttattgtac 1796521 gccatttatt tagcccccca atgctcgctg ataaatcccg ctcgtccgga acctgtccgg 1796581 tagcgctgat aatgtgctgg attcttttta taaaaatgct gatggtagcc ttccgcttca 1796641 tagaaaggtt cagcttttaa aatgtccgtt acaatcggat ctttaaagat gccgctttcc 1796701 gccagacgtt gcttggaagc ttccgcaagc tccttttgtt tatcattatg ataaaaaatg 1796761 gctgcgcgat aggaactgcc gcgatcagca aattgccctc cggcatctgt cggatcgatt 1796821 tgctgccaaa ataattcaag cagtttttca taagggaata catcaggatg aaacgtgatt 1796881 tgaacggctt cacgatgtcc cgtcgtttca ctgcacacct cttcgtacgt agggttttca 1796941 gtatggccgc ctgtataccc ggacaccact ttttcaattc ccggctgttc gtcaaaaggt 1797001 ttaaccatac accaaaaaca gcctcctgca aatgtggcga tttctttttt ttcagacata 1797061 ctggtgcctc ctttgttaat acgtggtatt attatattat agcatgtaaa aatagaatga 1797121 aaatgattct gcttttcaat aaaatctata ggttttaagc aatatgctta tgtaatggag 1797181 gttcacaaat ttgaaagtaa gaacacagat gatgtacgat atggaaactt tactccgtaa 1797241 agtctttaaa caaatacgca atgaaatcaa tgaaatttta gataaagagc tgtcgcggaa 1797301 tgaattcacc attcttcgaa tccttagtga acaagggcct aaaaaagtca ctgaatttgc 1797361 gcctatttta gaggtatcgg caagccacat tacggctgtg accgatgcgc tggtagaaaa 1797421 ggaatggatt acgagaatca gatcgaagga agacagacgc atcatccgca ttcatatcac 1797481 tgaagcgggc gaaaaagtcc ttcagcactt taacgagaaa aaaacggaat atttctttaa 1797541 acgctttgac tgctacactg atgctgaact tgccacgtta atcgagctct tcagcaaact 1797601 tgataaaaaa cggtgaaaaa aagcacatac cgatatatag gtatgtgctt ttcgcagtgc 1797661 ttcacttatt tttcagtaaa cagcttcatt gctttccagc ggccatatct ataatacaaa 1797721 aatgccgcgc agctgctaaa taaaaaactc attccgattc caagcccgat tcctttttgt 1797781 ccaagccaag ctgaaaatag agctgtgaaa ggatacctca acacccaaaa cgagatcaaa 1797841 tttaatacca gaacctgcag catcgctccc gcggccctga cgattccgtt cagcacaaaa 1797901 ttaaccccaa taaaagggta gaaaaacgcg atccacttca aatattgttc accaaatgcg 1797961 accgcatcag gctcactgat aaataacctt atgaggtatt taccaaatac ccaaatcata 1798021 accgcaatca ccagcatgca ggaaataaca gctatcacac ctagccttgc aattgttccc 1798081 actctttttt cgtttccgat tccaatattt tgccctgcca tactattgac ggccgtaccg 1798141 gcagccattg ctggaagcgt gatgatgcta tcaagccgct gcaccgcgcc aaagcctgat 1798201 accacgtgat ccccgtatga gttaacaaca ctcataatcg ccatcatacc gcctgtaatc 1798261 accatcatct gcagacctgc cggaatcccg agtttcaaaa tcagcgcgga ctcttcccac 1798321 ttgggcattc tcggaatcga gaatggcaca agcttgtgtt tgatgacata aaacaaccca 1798381 tacaaaaacg caatgccctg tgacaaaatc gttgaataag ccgctcccgc tattcccatg 1798441 cggaacacag aaataaagag cggcgcaagc actgtattca gtacaacagc aaacgcaata 1798501 aaccggagag gtgtcttgct gtcgcccagc gcacgaagca cagtactgat aaagttataa 1798561 ccaaacaaaa ataaaatgcc gataaattga atctgtaaat acgtctcagc aagcggtatc 1798621 attgactccg gcgtttttag aagacgcagc aaaagctctg agagaaaaaa accggccgcg 1798681 ccgaatccga tgcttaggcc tgttaataaa acaacaaaag cgttaatata cgacgccatt 1798741 ccttttatat catcttttcc tttttgctga gataaaatgg ttaacgtcgc attgttaagg 1798801 cccaaaataa aagacagcac ggtcaaaaca atcgtgcttg ataccgcggc tgccccaagg 1798861 gcctttgccc ccagtaaatt gccgatccac aagctgtcta taaattgaaa ggaaacctgc 1798921 aatgcgtttc cgagcataat aggcattgaa aacagtacaa gctgtttcag cacgttcccc 1798981 tgtgtaaaat cgtatgcttt catcttttct ccttgtgttc tcaaattttc ttcggaccac 1799041 acgaaaaaag agacgttgtt tcatgtctct tttttcatga cttatcggtt ttttttcggt 1799101 ctcgcatacc gaatgtaaac accatcacac ttaggaacaa ggcacaatag gaaacattca 1799161 aatacatttg atccatatct tcagcagcca gatgatgata agcaagccag ccgaagtaca 1799221 gggaaaatgt aaaggataat aaactgaaat actggtaaat ccgtttcatt ttcagtcacc 1799281 tctattgttt aggatggtaa taggaaaact caatttcatc tttttctaaa tttatcttat 1799341 ccgctttgac atacattcca ttcgttaaag gcatttctga caaacgcact tcaatgcttt 1799401 tatctccggg gtgaacatgg acaaatgacg gcaattcata aaagctgtcc atataattta 1799461 acacaaagct aattggtata ctcaatttcc ctaacgaaaa tttcgtgaca ttcagctcta 1799521 catcaccgtt ttttttcacg gtcggctcaa aagcgataaa cgcatcaata gacgtggaaa 1799581 atgccttgat tttccctgcg acatgaacat catcatcaat ctctacttta taatcaagct 1799641 tgtttgatgc tttgtcgttt aaatatgagt taacaaacgc agctaatgat tcttttgtgc 1799701 ttgtcacttg aaatccatac tcgctctcag atgcatcttt cacctgagcc tgttcccccg 1799761 gaagcaaaac aagtgccaca aacccggcgg cgaggataaa attgattgca agcaatataa 1799821 aaaacagtcg cttccactta ttcatgctgt caccctactc tttcggtaat ccttcttttt 1799881 taatggcttg atagacgcgc tttgcgataa gagaataacc cgtaccatta ggatgaaaat 1799941 catcttcctc agaaattcgg ctgctgtcac ttttttgatt aaacaaatct tcgatatgga 1800001 cgatttttgc atgtttatct tttttcagct ctttttcagc aatatggttc caatccgtga 1800061 cgacaccatt tatttcattt agttctgata atgtaaacgt aaacggattg tacatgctga 1800121 cataaatcag ctcagcgtga tcattcagct cgcgaatttc agaaatgatt ttttcaaagc 1800181 gcttttcgta cggtttttcc gcttcctgaa acggttcaac ggttaattgc agaaagtttt 1800241 ggcgaaggat tttcatcaaa tcattaccgc caattgtaaa aaagacataa tctgcgtcct 1800301 ttatgccttt ttgaaccttt ttatctttta gtttttctaa taaatcatcc gaacggttcc 1800361 cttttacagc ataatttttc acgtcgaccg ttttgacttg tttatctgac cggatagaat 1800421 ccgccacctt gccgacatat ccctttccgt cgggatctcc gactccttct gtcagcgaat 1800481 ctccgacagc cgctatgaca atgtgttctt ttgttttcgt ttcatgggct ttttgttttc 1800541 cctcagatga tgtacgtatg ctcgtacacg cagtaagaag caaaatcaaa ctggccatga 1800601 ttgaaaaaat gcgcagcttc aatcttgttg ctccttccca ttctactagt ggaaagtgta 1800661 tcatgtttta gaagatttgc aaatgcctag tctcttagct tacttgagtg tactggctga 1800721 cttcacatcg gaaatgatat catcgtacgg tgtattctcc actccattgt aatctttcag 1800781 caccttaccg tccggaccta ccaaataaaa agaagattga tgaatcactt ggtcctctcc 1800841 ctccggcttc tttacgatcg ctttaaagct cttaagtgcg aactcctcaa tctcactctg 1800901 gctgtatccc gtgagaaaat cccagttatc aaaagataat ggataatttg cggcaaattt 1800961 cttcagctgt ttcggcttat cgttttctgg atcaacacta aatgatatga tgcggacatc 1801021 tatattttcg gctttcagtt ttttttgcag atcggtcata tgagcggtca ttggcggaca 1801081 tatagtttca caattggtaa aaataaaatc cgccagccat acttctcctt ttaaactctc 1801141 taaagaaacg ttcttgccgt cttggttttg aaatgtaaaa ggctccacct cgtaattgag 1801201 cggatcttta atctgctgtc ctccgcatgc acacaaaaac agaaaaatca gcccagccgt 1801261 taaccccttg ataaccttca tgacatccat cctttccagc cagcataaaa acgctttcta 1801321 aaaccgtcct tactgtccca tgtttgtatt cgatactgag caaaaaaaat cctgcatgcc 1801381 tccccattaa cgattacaaa ggagggcatg caggtaaaaa acggcatgtt acgcgttgtg 1801441 ctttaacacc tcttgatgaa atacagcctg ataatctgcc cacttcatcc gccgcttcat 1801501 ataatgtcgg aaagaataca cttttgccct gctgtttgat gaaaacactt cttttaagta 1801561 gaattgcaaa tggtgatgta acataaagaa atagtgctca tcttccttta atacaggtat 1801621 ttctgtcact ttcacctgaa tcccgtcacc gcgtttgaac tctaggcttt tgagtaacaa 1801681 gctatcaatc ctcttttttg tttttcttct attatatatg atgccagccg ggctgtctgt 1801741 cattttgcgc ggttgtgtaa aaaaattaga ttagcaaatg gaacaagtcc tcatccttgt 1801801 tcacctctac ataatgaaac ggttttttgt tcatccgttc aatcagcggc ccataatcgg 1801861 ctttgttctg cagctcgatg ccgacaagag caggtccatt gcttttatta tttttcttcg 1801921 tatattcaaa ccttgtaatg tcatcattcg gcccgaggac ttcgtcaaga aattcgcgga 1801981 gcgcccccgc tctttgtgga aaattgacga taaaataatg ctgaaggcct tcaaaaatca 1802041 aggaacgctc cttcatttcc tgcattcttc cgatatcgtt attgcccccg cttaccacac 1802101 acaccacgtt tttcccttta atttgatcct tgtacaaatc aagcgctgcg acagaaagag 1802161 ctccagccgg ttcagcaaca accgcacatt cgttatataa ttcaagaatg gatgtacata 1802221 cttttccttc aggcacaagg agaatgtcat caacgacagt ttccagcgtc cggaaggttt 1802281 cctcgccaat ttttttaaca gccgccccat ctacaaactt atcaatttta tcaagtgtga 1802341 cgacatgccc agctttgttt gattcaaagt aggatgccgc tcccgccggc tcaacagcaa 1802401 ttacctttgt atcaggagac acgtttttca aatatgtacc taccccagag agaaggccgc 1802461 cgcctccgac acttgcaaaa agaaaatgcg gttctgtatc aatgtcgttt aaaatctcga 1802521 ctgcgagcgt tccctgtccg gccatcacat ccggatcatc gaacggatgg ataaacgtcc 1802581 gagattccgc ctcacagcat tcagcagcgc ttttatacgc gtcgtcaaac gtatcgcctg 1802641 tcaaaataat atcgataaat ccttttccga atagttcaac ttgagatact ttttgtctcg 1802701 gtgtagtaga cggcataaaa attttcccgt gaatgccaag atgtttacac gaaaatgcca 1802761 caccttgagc gtggtttccg gcacttgcac acacaactcc gttctctgtc tgctcgctgg 1802821 aaagctgttt cattttatga taagcccctc tgagcttaaa agatctgaca acttgcaagt 1802881 cttcgcgttt taaatagata ttgcattcat atctctcaga aagtctgtca ttcctctgca 1802941 aaggtgtgtg aatgacaacg tcctttacgt tttggtgagc cttcaaaatg tctttcactt 1803001 ggatgagaga gttttcttta agcaacggtt tcatgtacag attcctttct tgttttaaat 1803061 ccctatttaa tatgccatta taacatgaat attcaaaaaa taagacaatt atttttattt 1803121 aataattaaa aaaatacaga ctatgtccac cacatcttgt ggtaacttct gttcaaccat 1803181 tatcctgcag agccaagaaa aaagatgatc gtaaaataaa gggtgttttc aaccaaaagg 1803241 catgatataa tgaaaccaat tagaaccaaa aggagccaat tgatgaatag tgcaccaaaa 1803301 ctcaatacat ttcaacatct aatcggagaa catcaaactt ttctggaagc gaagcgaatc 1803361 gccaagcagt tctcgttatc ggagcttcct gtcttaataa caggaaaaat cggaacaggc 1803421 aaaaatcact tcgcacatgc catacacttg gaatcttcga gaagcaatga accgtttata 1803481 agcgtcaatt gcagcaccca ttcggaagaa acccttattc atgagctttt tggccctaac 1803541 ggaaacacag gtgtttttca aaaagcggta cgaggaaccc tttttcttga tgatgtatgg 1803601 cgcatgcctg cttctgtaca agctcagctg ttaaaagcgc ttgattcaga cacggagaaa 1803661 ccgcgaatga tctgtgcttc tgcagaccga tccgtggaac atacattcag gcaagactta 1803721 ttctacagac tgaacatttt aacgctcaca ctgcccgaat tatcggaacg aaaaagcgat 1803781 attccgcttt tgacacagca ttttctctca aattctggtc agcaattgtt aatcgatccc 1803841 tccgtttttc ccgtgcttga gaagcatgca tttgaaggca atgtcaggga attaaaaaac 1803901 gctgcagatt atatggcggc agtatcaagc gggggaacga ttcagccata tgacctgccg 1803961 ccgtatatta gaggcacgat agacggaaaa acgtcgaaga aaaaagcgaa actgcttact 1804021 ttaatggaaa aagctgagtt tttgtttatt ttggaaacaa taaaagtatt gaacgaaaaa 1804081 ggagaacctg ccagcagacg gatcatttct gaacacagca aaaataccca aacctcgtta 1804141 actcctcagc aggtcagaag ccgtctcgac tatttggaga aaaaagatta tgtcaccaaa 1804201 agccgcggac gcgcaggcac aaaaattacc tttgagggct tgagctttat agagacgtta 1804261 aaaaatcaaa tgatctagcg atcgaaagga gaatgtactt gtttacaatc aaagaagaga 1804321 tcgccaatgc gattacacac ggcatcggtg tcctcttatc catcccagca ttagtgtttc 1804381 taatcatatt tgcggctaat tacgggtctg catgggacat tgtcagcttt acaatattcg 1804441 gtgtctctat gctgctgtta tatttgagct ccaccctgct tcacagcatc acacataaaa 1804501 aaacgaagga cattttggag attattgatc atagcgcaat ttacgtactc atcgccggaa 1804561 cctacacgcc ttttttgctt gggccgctga aaggcacact cggctttacc ctgttggtta 1804621 tcgtatggtc acttgcccta ggcggaatcg tttttaaaat tttctttgtg aaacggttta 1804681 tcctattgtc aaccttcgtg tatttagtca tggggtggct gatgattatt gcagttaaac 1804741 ctttatatgc ttcactgagc ggagcgggat tcagcctcct ttttctcggc ggcattttat 1804801 actctgtcgg aaccatcttt tacatttgga aaaagatccc cttccatcac gccatttggc 1804861 acagctttgt attgggcggg agcgctgcca tgtttttctg cgtgctcttc tattgtgtaa 1804921 aggtgccttt cctttcgtaa cagtaacaga aaagcgcagt cttcacgact gcgctttttt 1804981 atgcacgtaa ttgtttttca ttggcaggta tataagcttt tgaaaaggac aattcaatgt 1805041 ctgccggttt taagcgttta aaaaacgagc cattttgcat gttatctgtt cctttcgttt 1805101 ccaccatcac caacggaaga tgatagcggg ccgcaagttc tacaggatca atagaaccat 1805161 ctagtgaaag aatcaggctt tgtccctttt ccagctgttt tgtcacatct tcatatacct 1805221 tttctgaatc cccgtctgaa atcacatcca tccgatccag ccattgcccg ataaaaggca 1805281 agcggaacac ttttgggtta gcgataaagc cggccggttc ctcaatatat ccagcaatta 1805341 aggccagttc agccaaacgc aaacggggat gcacatacaa aacaggaccg tgtggtattg 1805401 gctctggctg atggatcgtc acaactgaac cggagatgcc gatacagcct tctaaaaacg 1805461 cctttggctg ttcgtacaca agagccatct gttttttgta tgacagacgg ggatcgagca 1805521 ttgtttgatt aaataattgt ttcatatttt ttaacagcat atacacaata taaaccacta 1805581 gaaggctgta gcgaaccaat taaaatcctc ccgctttaga agaattcttt ttttcataca 1805641 ttagaaattc gtaatcatac gggttttttt cgtctttggt cccctgctca gaagaaacca 1805701 gcttccaatt ggattcatca aattcaggaa agtgacggtc accctcaaac tcgtgatgaa 1805761 ttttcgtcat atacagtctg tccgcataag ggaacaggtc cgtatagagc tgagcccctc 1805821 cgatcacaaa gcattcttca gggcctgaac aaatgtccag tacatccttt aatgaactga 1805881 caaccgtgca tccctgaaat tctgaatccg gcgctgaggt aacgacaata tttttccgat 1805941 ttggaagcgg acgtccgatc gattcaaatg ttttccggcc cataatgatt gaatggcccg 1806001 atgttatttt cttaaagtat gcaagatcat tgggcaaatg ccacggcaaa tcattgtctt 1806061 tgccgataag cctgttggca tccatcgcaa aaatgaatga aatcatacgc tgaccgcccc 1806121 ttttatatga ggatgcggat cataatcctc gatgataaag tcctcaaatg caaagttaaa 1806181 aatagaatca acctttctgg cgaaacgaag ctgcggaagc ggtctaacat ctctttccag 1806241 ctgcaaattg acttgttcaa tatgattttg gtaaatatga acatcaccaa acgtatggat 1806301 gaactcgccc ggttcaagcc cagtcacatg agcaatgatc atggttagga gggcataaga 1806361 tgcaatatta aacggcacac ctaagaaaac atcggcagag cgctgataca gctgacagga 1806421 cagcttgccg tcagacacat agaattggaa caggcaatgg cacggcggca acgccatttt 1806481 atcaatttca ccaacattcc aggcgctgac gattaagcgt ctggagttcg gatttgtttt 1806541 aatatcttca ataagacggg aaatttgatc aatggtttct ccatcagctc cccgccaaga 1806601 acgccattgg gagccatata caggtccaag ttcaccgttt tcatcagccc actcattcca 1806661 gattcgcact ccgttttcct gcagatagcg tacattcgta tctcctttta agaaccacag 1806721 cagttcatgc gcaattgatt taaagtggag ttttttagtg gtgagcatcg gaaagccttc 1806781 ccgtaaatta aatctcattt gatatccgaa agtgctgatt gttccggtcc cagtccggtc 1806841 tccctttttc tcaccatgct ctaaaacatg tctgcagaaa tccttatact gtttcatttt 1806901 tttcatcctt taaaagtagt cttctagtag tgtaacacaa taaaaaatca tttctgaacc 1806961 cagaaatgat ttttttatag tcagctgacg acaggctttt catcctgttc tttttcttca 1807021 tcttgcagat cctgatgcgt atgtgcaatt ctgctcgccg ctgctgcagc aagagctgcc 1807081 acaatatcat ccaaaaaggt gtgaataccg tctggacttt catcaagttc cttaataatt 1807141 ccaatcttct ctttatccaa ataaccgaaa ttggtcaaac cgatcgaccc gtacacatta 1807201 acgattgaaa gcgggataat ttcatctatg ccgtaaagcg gttcatccgt ttcaacaagg 1807261 tgctgcagcg gttcggggag aagtttctgt tctgcaagct gatcgagtgc aaggcctgtc 1807321 aaaacagcat gaataatttc acgtttgttc aggacttttt ctacattctc catgcaaaca 1807381 ctgagcggca gatttggatt gtatttttcc tgaagttttt gaacaatccg tgcaatatct 1807441 tctatcataa cgccccgttt gttcagcata tcctttgtta tatcgaccat ttcattcatt 1807501 gtgtactttt tcatgtctaa tggcatctcc tttaggcact catccagttg ggaggcgtgt 1807561 tgcggtccca gtaaatgctc ccaagctcat gatgtgattg aaatccatct tctgctgtat 1807621 gataatgaaa attaaaccag tagccgtcat gaggcgggtg gtctcttcgc acatggaatc 1807681 tgagaagatc ttctccagtt gtccgattgt aaacgttgaa aattttttcc gttttgcccg 1807741 ctgaaggcat gcttgagatc acaacatctt ggtacgcctc atcatcttgc aatgtcgcta 1807801 aataatcact aatcacattt tcgatttttg gcaggatctc tttccgatag tcatcctcaa 1807861 tgacaggagc gattctgctg ccgaatttta aaaaggactg atcctcagcg ctgtcaagga 1807921 gctgttcctt gtacgattga aaaagcagtt caggatctcg cctgtcatcc gactcatcat 1807981 cgtacaggtc atgctcatca taaaaagcgg tgtaatcatt ctgctcaaga ctgctcggct 1808041 gtccggaagg cttgtccgcc ataagggcag ccggaggaga tacgagcccg aacgttacaa 1808101 tggtaaataa aaccacaagg gtctttctca tccacaattt catgactgct tattcctctc 1808161 tattttattg tcatgtttct cttattttag cacatccaaa acatgcaagt catgtactat 1808221 atgaaactga tatgcaaatt aggagattcg ttgctatgca ctttgtgtaa aaacgcttac 1808281 aatatttcat gaaaggaggc tttccgcatg attgacgctc tgtttgccac agtttcactc 1808341 ttaacattat tatactttgt cgtcatggag gtcaccgatt aacagaaagc ccgtgatatg 1808401 aatcacgggc ttgtttgaat gacgccataa tggaacagtg ctgtttttct tttcatgacg 1808461 ttaaaaccaa actgttcaaa ccgcgggctt ttccagtggt cttttagcac aacgcttttt 1808521 ctggcgactc gtaccgcttc attgatacat ccttcgtgca aaacggaatc ctctgccaaa 1808581 tcacgtaaag gcgcgatgcc gtcagaggtt tctacaggtt catgaaacat tggatcgaaa 1808641 taaaccacat caacagagtt gtcagggagc tgcttgatgt gttcaaagca atcaccattc 1808701 ttcacctgga ttcttctcat cgcagcttga agctcttcta tacccgtttc ccatgaatgc 1808761 agccccgtcc tcactaaaac agacacaaga tggttttttt caatcccaac aacagaaccc 1808821 gtttcgccta ctgccatact tgcgataatg gcatctgacc ccaacccgag tgtgcaatct 1808881 aaaaacgtat ccccttcaga taagccggca gcccgaagca taggttcttt ctccccctgt 1808941 aagaagcgtt tggctctgaa catcgctgta ttcggatgaa aaaagaattt ggcaccttgt 1809001 ttcgtataca gctcaaaccg ctctttgccg accacaagca aatcacgttc agctgatttc 1809061 agcaggtgct caaccgtttg tttattccgg ccgcagtatg gcatatttag ctctttagaa 1809121 agctgctttg cagtttttat ggtgtgttca gacggtctat agcttgttgt tatcatcttc 1809181 tgtactccca aaaagaaaat gcccggagaa cgggcattta gcagtgcgca tcgaaggcag 1809241 cagtcagatt tttcatgatt tcttccatat cgtgtccttc aatttcatga cgcggaataa 1809301 aatgtacgac ttctttgcct ttcaaaagag ccattgatgg tgaagaaggc tcctggccag 1809361 taaaatactc acgcattttc gcagtagctt ctttatcttg gcccgcaaat acagtcaccg 1809421 tattgtcagg tgttttgtca ttctggagga ctgcctgtgt agccgcagga cgcgcaaggc 1809481 ctgccgcgca gccgcataca gagttaacga ctacaagagt tgtgccctct gccttttcca 1809541 taaagttttc tacttcttcc gctgttgtta actcttcaaa acctgctcca gtcagctcgc 1809601 ggcgcatcgg tacgacaagc tggcgcatgt attcttcata agccattgac ataaaaaaag 1809661 ccccctctag tatccttcat ctgaagtaaa ggatactata gagagggccg gatttcaaat 1809721 gttcacgcct taaaataaaa gaaagtgtcc ccagctatct agattttcat aataccgccg 1809781 gtgttggcac ttgtcacaag tttagaataa cgtgccaggt agccggtttt cactttcggt 1809841 tcaaaacctt tccagttcgc ttttcgtttt tcccactctt cttctggcac ttgtacatcc 1809901 aagatgcgtt tttcaatatc aacgataata tggtctccgt tttcaacaaa ggcaagcggc 1809961 ccgccctcag cggcctcagg tgatacgtgg ccgattgaga ggccacggga ggctccggaa 1810021 aaacgtccgt ccgtaatcaa tgccactttt ggcccgagtc ccattccaac gatttgggat 1810081 gttggcgcca gcatttccgg catgccaggt ccgccttttg gcccttcgta tctgatgatg 1810141 acaacgtcgc cttcttttac ttttcggttg ataatgccgt caagcgcctc gtcctgagaa 1810201 tcgaatacga cagccggccc ttcgtgtctt gtaatcccat tctgtacgcc gcctgtttta 1810261 atgatagcgc cgtccggagc tagattaccg aataaaacag caaggcctcc cttttcagtg 1810321 aatggttgat ccagcgggtg aatgacgtca taatccttta cttcatgtcc ggcaatggtt 1810381 tctccaagag tttttcctgt aacagtcagc gcatctaaat gaagcgctcc ttctttcttc 1810441 gaaagctcat tcagagccgc tgaaacgccg cccgcttcgt gaagatcttc aataaacaca 1810501 tccgatgcag gcgccagctt agccaagtgc ggcacgcgct cagcgacttc gttaatgcgt 1810561 tctaaagagt attcaacgcc ggcttcgttt gcaagggcaa gggtatgaag aacggtattt 1810621 gtagaacctc cgagcgccat atcgagtgca aacgcgttat caatcgcttt tactgtaaca 1810681 atatcacgcg gtttgatatc tttgcgaatc gtttccatta attgcgcagc cgattttctc 1810741 acaaactctt tgcgttccgg agatgttgcc agaatggttc cattacccgg caaagcaaga 1810801 ccaagtgctt ctgacagaca gttcattgag ttcgccgtaa acatgcctga gcaagacccg 1810861 cacgttgggc atccgaactg ctctagttct tgaagctcgt tttcgttgat tttccctgct 1810921 tggtaggcgc ctaccccttc gaatactgag gaaagggaga tttttcgccc gtcacttgtt 1810981 cttcctgccg ccatcggtcc gccgctgaca aaaatcgtcg gaatgttgat gcgcattgcc 1811041 gccataagca ttcccggtgt gattttgtcg cagttcggaa tacagaccat tccgtcaaac 1811101 cagtgtgcgg atacaaccgt ttccacagag tctgcgataa tttcacggct tggcagcgaa 1811161 tatctcatac cgatatgccc cattgcgatg ccatcatcta ccccaatggt attaaattca 1811221 aacggaacgc cccctgcttc tctgattgct tcttttacga ttttcccaaa ctcctgcaag 1811281 tgaacatgac cgggaacgat atcaatgtat gaattacaca ccgcaataaa cggcttgccg 1811341 aaatcctctt cttttacccc tgctgcacga agcaaactgc ggtgcggagc tctatcgatt 1811401 ccttgtgtga tcatattact gcgtaattct gccatggtga tcctcctaaa ttctttcaat 1811461 tgtttgattg gattttattt tgacaatttt cagtttattt atgggctgtt tttgcaaata 1811521 agataaatac aggccgccct caccttgttt tgttctttcg tgtttttata tttatatagc 1811581 tttctttcga tttgaaccct ccaactatta atattgttac ttactataaa tagttttcgg 1811641 atatttttca acaatattcg aaataatttt tataaaaagt gaattcacat aaaaaaggtg 1811701 catgatctgc acctttttta tctttattcg cctttttttc tgctttccgt catttgtttc 1811761 caaacagaac cttttgcttc ttctccatgc tcaatacgtt caagcgccat tttgacttga 1811821 aggctgacct caaattcggg gtcatcttcg gcagcgcgca aagcttcaat tgcactttca 1811881 tcgccgactt cgtacaggaa catggcggca cgccagcgaa caagcttgct ggagtcgctt 1811941 aatgacttga tcatagcagg aatggcttga ggatcgccga tatcagacag gcagtctccg 1812001 gccgttcttc tgactgatac agctttgtcc tcaagtgctt tatacaatag aggaagaaca 1812061 tcaggtgttt caatcattcc taagtacaca acagcctgtc ttctgatgga cacctttgga 1812121 tcatccaatg ccttctgtaa aaccgggata tcctcttctt tcggatccat ctgttccaag 1812181 tgtgcataac gctttttcca gtcctcatca tccagcatat caagcgttac tttatacgct 1812241 ttgcgctgta cagcttgttt tgcttcgccc tttccttgag cggctgcttc agtcagtcgt 1812301 ttcagccgtt catcactgta tgccgcttga agctcttctg tcacatcatg gccgatttca 1812361 tcaaagtcac cgaatctgac accttgttct ttccaagccc gctcaaacac aacattggaa 1812421 gcttcagatc taagttttaa gatcgcctgc tgaaagcgtt caggtaagcc gaagcgttct 1812481 tcccgctctc catcggttaa tttaacttgc ataggaatgc cgctgaacat ctgcacaaaa 1812541 acttttacct ctccaaaaga ttcttgatca gaacgatttt cttctgcgct ttcagcactt 1812601 tccatcccaa atgcagtgcg gacttgcggt aaaatgtctt tccagtcgta tcttgcattc 1812661 cgttcaacag caagaaaatc tgcgacgtga tatacccctt taactccatc tattttaagg 1812721 atttccgcta taacaagcgg tgcgccttct gcttgctcag gtttatagtt attgcttttg 1812781 cccgccggaa gctcttccgt taagatgact ttcattgtat tcgggcttgg tgtaggttca 1812841 attgatttta tcttcatgat cgtcctccta tagcatatct gtgacttatt ctatcatagt 1812901 cgctccaagc cttctattac gacgtttcgg catcaatccc gggtatgtct ttttctaatt 1812961 ggcggacaaa ttgaagcata aaattgtgtc tttcttctgc cagttcccgt gcagtgtctg 1813021 tattcatcat atctttcagc cgcagcagct tatgaaaaaa atgagcgtag gcgctttgct 1813081 catctccata aaggccatgc ccttttgcgc ccgcaaacat gaaagctctc gcaatgccga 1813141 cagcaccaat cgcatcaagt ctgtcagcat cctgtacagc ttttccttca attgagagcg 1813201 gctccttcgc caatttcccc ctgtcccgaa aggacatcct tgttataata tgaatcaccc 1813261 tgtcagcatt ctcttttcct actccgaaaa aaacgagctg atcatatact tcgctcacag 1813321 aaagcctgac cgtgtcaggc agcttcacat caattaaatc atgaaccaaa gccgccgttt 1813381 caacaatgaa caaatccgct ttttcctttt ctccaatata cgctgcaaga tctgctactc 1813441 ttgatacatg atgccagtca tgtccagagc tttcgtcagt caggatagat tgaacccatg 1813501 tcctgatttg ctctgcctgc ttcaattcct tcacaaaaac accctctttt tattgctcta 1813561 atagcttcac gatatcgtct tccaactctt tcggatttgt atttggtgaa taacggccaa 1813621 cgatttctcc atttctatcc actataaatt tcgtgaaatt ccacttgatc gccttagttc 1813681 ccagcatccc tttcgcatgt tctgtcaaat acacaaacag cgggtgggcg tttttcccgt 1813741 ttacatccac ttttgaaaac ataggaaatg taacaccgta atttgtttca caaaattcct 1813801 gtatgtcagc ctcttcacca ggctcttggt tcatgaattg attgcagggg aaccctaaga 1813861 tctccagccc ctcctgctga tatgtatcat ataattcctg cagctgcttc aattgggaag 1813921 taaaaccgca cttacttgct gtattcacga tcatcagtac ctttcccgcg aaaggctgaa 1813981 gtgtcatgtc tttccctgtg attgtacgta ccttcatatg ataaatagac atgtaagtcc 1814041 ctcctatgtc cttggtgctg attattttac cttttttaaa tcgcaattca aaatgtaaac 1814101 atcaattaag aactcataag aaacctaacg atatgagcgt cagttcatta tcaattcata 1814161 tggctcgttt tttatcttat cattctataa aacattacaa ttccctctta catctttgaa 1814221 aatcatttta ctgtgaaacc aaaaggcgtg tcagtgcgtt ttatttaaag agttttctgt 1814281 tgtttccccc tcaacacgta tagatagatt gaaaattggc gtgaaaattc ctataatgaa 1814341 gaaaattaaa cggggaaata atggaggtgg cacgttgcct attaatatac caacacacct 1814401 gccggcaaaa caggtgcttg aaagtgaaca tatatttgta atggatgaaa gcagagcatt 1814461 tcatcaggat atccggccgc aaaaaattat tatattaaat ttgatgccga aaaaaatcca 1814521 aacagagact cagcttctca gattgcttgg aaattcgcct ttacaggttc atttcacatt 1814581 tttaatccca agcacacaca cgccgaaaaa tactgcgaga gaacaccttg acgaatttta 1814641 cacgactttt tccaatatcc gtcacaagag gtttgacggc atgattatca ccggtgcgcc 1814701 gatcgagcat ttggcgtttg aagaggtttc atattgggaa gagctcaagg aaatcatgga 1814761 gtggagcaaa acaaatgtca cttcaacctt gcatatttgc tggggtgctc aagcaggttt 1814821 gtattaccat tacggtgtgg aaaaaattca aatgccgaaa aaaatcttcg gtgtgttcga 1814881 acataccgtt ctttcaaaac acgaaagatt ggtaagaggt tttgacgagc tatactacgt 1814941 gccgcattcc cggcatacag atataaatat ggaacagctt caagcagtgc ccgagttaaa 1815001 cattcttacc gcatcaaagg aagccggggt ttgcttaatt gtgtctaaag acgaaaaaca 1815061 agtctttttg acagggcacc ctgaatatga tacaaatacg cttcttcaag agtatgaaag 1815121 agatttggaa cgaaaccttt ctactgtcga ggcccctaaa cattattttg caaaaggcag 1815181 caacgagcca gtgaatcgct ggaaagcgca tgccacatta ttgtttatga attggctgaa 1815241 ttattacgtt taccaagaaa ctccttatga atgggactaa tttttctttt tttagtgata 1815301 cgctgagcaa aaaatatgat aaaatacatc tgattcagtc tgcgtataac aaaaatttaa 1815361 aatactggaa tccaaatcat ttaaaattag cttaactttt tcactgcatt aataattcga 1815421 ttatgtattt gtgttatgtt tatgtataga caataactcc ttacgatgca tgaagcttgc 1815481 ttgttgttga ttacattgag gtgaatttac ttgaatacca ataaaagagt attaattttg 1815541 actgcaaatt acggaaatgg acatgtgcag gtagccaaaa cactttatga acaatgtgta 1815601 cggctcggct ttcagcatgt aacagtttct aatttgtacc aagagtcaaa tccgattgtt 1815661 tcagaggtaa ctcaatacct ttatttaaaa agcttctcaa tcgggaaaca gttttatcgt 1815721 ttgttttatt acggagttga caaaatctat aataaacgta aattcaatat ttactttaaa 1815781 atgggtaata aaagattggg cgaacttgtc gatgaacatc agcccgatat tattattaat 1815841 acatttccga tgatcgtcgt gccggaatac agacgccgaa ctggaagagt cattcctacc 1815901 ttcaacgtta tgactgattt ttgtcttcat aaaatttggg ttcacgaaaa cgtggataaa 1815961 tattatgtgg cgacagatta cgtgaaggaa aaactgctgg agatcggcac tcatccaagc 1816021 aatgtaaaaa tcacaggaat tccaatcagg ccgcaatttg aagaatccat gcctgttggc 1816081 ccgatatata aaaagtacaa tctttcacca aacaaaaaag tgcttctgat catggcaggt 1816141 gctcacggtg tattaaagaa cgtaaaagag ctgtgcgaaa accttgtcaa ggatgaccaa 1816201 gtgcaagtag ttgtcgtgtg cgggaaaaat acggctttaa aagaatcttt gagtgcgctt 1816261 gaagcggaaa atggtgacaa attaaaagtt ctgggctatg tggagcgcat tgatgagcta 1816321 tttcggatca cagattgcat gattaccaag cccggcggca ttactttgac agaagccaca 1816381 gccattggag tgcctgtcat tctgtacaaa cccgtgcctg gccaggaaaa agaaaatgca 1816441 aacttctttg aagaccgcgg agctgccatc gttgtgaacc gtcatgaaga gattctcgag 1816501 tcagtcactt cccttcttgc agatgaagat accttgcatc gcatgaagaa aaacattaag 1816561 gaccttcatt tagcaaactc ctctgaagtg attttagagg atatcctgaa ggaatcagaa 1816621 atgatgaccg ccaaacaaaa agccaaagtg ctatcgtaat ggcgtacttg agagcatacg 1816681 aaaatcgtgt gctcttttta tttatattca gccatcaata aaagcggtta cattttttta 1816741 tggaacttgc ccttcttttg aaaaataagc cgtttcgcaa cttgacgggt gctcccagat 1816801 ggtgtatagt tgaaccatca tttaacaatg aatcaaagtt agatgatgac aaaatttttt 1816861 ttagcacatg ggtgctacag tactaggagg aattaagcaa tatgcaaaac ggtaaagtaa 1816921 aatggttcaa caacgaaaaa ggattcggct tcattgaagt tgaaggcgga gacgatgtat 1816981 ttgttcactt cacagctatc gaaggagatg gatacaaatc attagaagaa ggacaagaag 1817041 tttcttttga aattgtcgaa ggtaatcgtg gacctcaagc ttctaatgtt gtaaaactct 1817101 aaactcaata catgatgatg agatgacaaa tagaggagag gcattcgcct ctcctatttg 1817161 attttcatct ggatttcaat cgccaaaatg ttttgtttac acctctgttc aatctcttca 1817221 acatactttt ccattgatgg ttttcctttt ttcgcgatat cggccagttc ttctaaatca 1817281 ctgtatattt ctataaatgt tttgtgaagg atcaacttca agtctttatc atccatagct 1817341 gcgttcccct tctctatcaa gatacctcaa atagtaaaac ggtcctattt attctggttc 1817401 aatagttata tcggcttatt tttattttct tttctatttt ggtacataaa tttcaaaaaa 1817461 actctgcaaa ataatggcgg aggtgttttt tgtgacttca gaatttcata atgaggatca 1817521 gaccggcttt acggataagc ggcagctgga actagcggtg gaaacagcgc agaaaacaac 1817581 aggagccgcg acgagaggcc aaagcaaaac attagtcgac tctgcatacc aagccattga 1817641 ggatgctaga gaactgtcac aatctgaaga gctggcagct ctcgatgatc ctgaatttgt 1817701 aaagcagcaa cagcagctgc tagatgacag cgagcatcag ctggatgaat tcaaagaata 1817761 aaaaccgcag cttctgcggt ttttattttt agtgattggt taagacatct ccgtattgtt 1817821 tcaacttttc accaaccgta catttattga tacaaaatga atgcgcataa gttttgccaa 1817881 attctttgcg aaactgcttc ttaataaaac agtccttgca atattcatcg tgcagttctg 1817941 tcagttcttt aaagatcatt ttcttatcca atatcgtcat ctccgttacg gtctaatttc 1818001 gtgtggcttt ctacgaattg atgggataga atttttttag cgaggccgtc agcttcctga 1818061 ttgtcttttc gttgtattgt ttcgtaggtt ggagtaagct tcagcgattc aaggagtgct 1818121 tctattttgt ccagccattc attatgagat ggatcataac aaggccagct gccgtcaagc 1818181 tgattcagca caacaagcga gtcccctttg attgtaattg aatttctgct tgccccaagc 1818241 tctcttactt ctcttattgc ttcataaagc gctgcgtatt cagcttcatt attggttttc 1818301 agccggaagc ttttattttt tctcaagcga tgccgggttc ctcccaatga ataatagatg 1818361 acgatcccga gaccggccag ttcgctctct ttatcgaaac tgccgtcaaa ataaacagta 1818421 atgtcatcag gctcttgagc aagctcctct gtcagctttt ccaattcctt cagcgtccag 1818481 ctgccgcctt tctcgtcttc gaactctagc tccttcatgt atggaaaacg gccaagttct 1818541 ctggcgaacg tacgtgcctg ctgtgctgtc agccagtctt cgctaaaaaa tgagacggat 1818601 cccgttcctt ttgcttctat tttcaaatgc ggtctgagct tcattacaat caccttacca 1818661 ttcattagtt gccgggctta tgctataatc aaaccaatct taccccggaa aggaagcttt 1818721 ttcatcttgt ttaataattc gttttggatc ttttttgcga tcattcattt tatcattgtt 1818781 cttttatttt ataaaggatt tggcaaaatg ggactgtttg tttggatcgg ttttgcgaca 1818841 gtctgcgcca acctccaagt cgtcaaaaca gtcgaactgt ttggcttaac agcgacactc 1818901 gggaatgtga tgtatggcac aatctttttt gcgacagatg tgctgaatga aaaatacgga 1818961 ccagctgaag ccagaaaagc ggtatggctc ggattctcaa cgctcctgac gctgacattt 1819021 gtcatgcagg gcgtgctgct tttcgaaccg gcttccagcg acatatcaca aacagcgctg 1819081 gaaacgatct tcggattcct tccgcgagtt gcgttaggaa gtctgcttgc ctttatcttc 1819141 agccaaacgc tggatgttta tgtatattcg gcaattagaa ggatatttcc ttctgatcgg 1819201 cttttatggc tcagaaacgg cggcagtaca gcagtcagcc agttgtttga tacattcata 1819261 ttcactgcag tcgcctttct cggcatttat ccggcagacg tgtggcttca tatttttatt 1819321 tctacatatt tgattaagtt tgcggtatct ttaatttcat tgccttatgc ctatgcagcc 1819381 aaaaaaatga tacctaatga tgaaaggagt tcataatgcc tacagaaata tatgtagacg 1819441 gcgcaagcgc cggtaatcca gggccttccg gtatcggcat ttttatcaaa catgagggaa 1819501 aagcagaatc tttctctatt ccaatcggag tgcatacaaa ccaggaagcg gaatttcttg 1819561 cattaattga agggatgaag ctatgtgcaa cgcgcgggta tcaatcagtt tcctttcgaa 1819621 ccgattcaga tattgtggaa cgcgccactg agcttgaaat ggttaaaaat ataacgtttc 1819681 aaccgtttgt agaagagatc atccgattaa aagcggcatt ccctcttttt ttcatcaaat 1819741 ggataccggg caagcaaaac caaaaagccg atcttctggc aaaagaagcg attcggctga 1819801 atgaaaagaa ttaaatcttg atcattggtt catcctaatg gcgaggtgaa ctaacatgaa 1819861 aaagaaagat aaaggccggc tgaccggcgg tgttactccg caaggcgacc tggaaggcaa 1819921 tacacataat gaccctaaaa cagagcttga ggagagagca aaaaaaagca atacaaaacg 1819981 ctagagagga tctaaacgat ctctctagcg ttcagctttt caagcatacg ctcaattcct 1820041 ttaatttggt ggcggcgaag catgtcagcc gcctgctcca tttgcaaagt aaataaagcg 1820101 tctttcagtg tgcaggccag cggcactgag caatggattt ccgcaagctt cctcgacatc 1820161 tccaaatcgc ttaaaccttg ctgaattttt ccctgctgtc cttttggaag aagagaaaga 1820221 ttttccaata aacggtcaat cgtttcgtat tcacgaatca gtttgtaggc tgttttttct 1820281 ccaatgcctt tgactccggg atagttatca ctggaatcac ccataagcgc tttaatatca 1820341 atcaaagcct tcggcattac gcctgtttct tcataaaaag tctcttttgt atagacttta 1820401 taatttccga ttcctttttg aagcaaagca acgcttactt tatccgttaa cagctgaagt 1820461 aaatctctgt cccctgttac caccgtaatg tccgcttcat tcgcaaataa atcggcaaga 1820521 gtaccgatac agtcatccgc ttcatagccg gcaaagccaa tattcatgat tccaagctct 1820581 gcggctgctt cctttgccaa atcaaactgc ggaatcagct ccacaggcgg cgcgctgcgg 1820641 ttggccttat aatcttggaa caagtcattt cggtacgttt tgctccccat gtcccagcag 1820701 cagacgacgt gtgtcggctg gaatgtttcc acagctgtaa tcaaatgctt taaaaagccg 1820761 ttgacgccgt tcgtcggcac cccgctgtca tttatcataa agttgcgatg tacggccgtg 1820821 gcaaaaaagg cccggaataa aagagccatg ccgtcaacca gcaatagttt attattattc 1820881 atcaaataac tcccttttct ttcattcctt ctattttatc ataaagcagc ccaaaaataa 1820941 aaaacagtat ctctttaatt agagatactg tttgaatatt tatcaatcgt tgtgtctttt 1821001 gttgctggcg atcagctttt cagcttcgcg tcctgcgtaa gagtcaaaat gggtttgaaa 1821061 tccgtttttc tttttggcgt tgttattcgc ctgtgcattt ctgtttccga gctttgttct 1821121 gcccaacatg aatcccccct tacgtcggat gcatatagta tatgcttccg gcaggaggtt 1821181 cactcgcgac aggatcatcc agcttacatg cggcttacgt attctctgac catttctttt 1821241 gatacaagcc gtcttgtcgg gacgatgcct tttttagcga gctgattcat ttgctcggta 1821301 atttcattaa ttgcatctgt agtataaggc tcatcgtttc tgcatttagc aacagcttct 1821361 tcaatcgcca attcacgcat attttcaaga cgcataaatg ctttgatatg ctcgtgctgt 1821421 tttgatgaat gtgctgaaat tgctttatgt acctctgaca ttaatcgttc atctcgcttt 1821481 tttctattta gtctatcatg acttgaaata caagccaact gaattttaca tttttattgt 1821541 attgtctgaa tttttccagg agatgcacgc ctgatacgcc atttcaatct ctttcgcatg 1821601 ttccccttcc gcatatcctc ttaaatatgt ctctttttga tccgttattt gcgcgattgc 1821661 tttttcaccc atatcttcct gtaagcgtct gaggtgagca gtgtaatgag atatcaggct 1821721 ttcttcttca ttttttatcc atgcctctgt gattttcgta agtttcatcc gtacagcttc 1821781 gataaaggtc gcttttcctt tctgctcaaa aaactgcttc ggtgatttga tctcttttag 1821841 ttcctgctca aaagcacgtt cttctatttc cggttcaact tccttcaact gtatgccgtt 1821901 cgaatgctga tcacccgcat aaacggaaaa ataaccgtcc tcgtttaatg ttttttgaaa 1821961 atgatccagc cattcttcat tgatatgccg ttcgatgaaa ccgctcatgc gaacatcaag 1822021 cgttttgatt tcctgaatat attcaaatag atattcatgt aaggctgttg tcatcgcttt 1822081 actgacgttc tttttccaat ccccgttttg cagcccggga tgaaatgccg attttaataa 1822141 atcatttgca aaatatgata atcgctgtgc aatgtgatat agctgctctc ttgtatcttt 1822201 ttttactttt tcaatgatgg tttttgagtt ccgccgtttc tcgatatcgg ccgctgtccg 1822261 ctcaaatgac agcataaggc actgtttctg cgcttccttc tcttctcggg actgatgctg 1822321 ggattggtga agctgaaaaa cagtttcgca tagtttgtct gcctccgaac tgagctgcgc 1822381 tgctgacgct ttttttacat ccacttcgat aaaccggtct aagtgttttc ttactttcga 1822441 gaactgatta taaaatgact ccggttttcc caccagttcc tccttacttg atacggtaaa 1822501 gagctgcggc tcataaaccc cttcttttac aagctctgcg ctgacataat cggtcactgt 1822561 ttcgagctct gttttatctt ttgcaaggtc tgcagcatta ataataaaaa acattttatc 1822621 catgctgagc gattctttca caagtccaag ctttcgcaaa aatgaacggt ctccttttga 1822681 aaaagagtgc tgataataag tcatataaaa aaatgcatca gcatctttga tatattggaa 1822741 tgccagttct gtatgccgtt tattcatgct gctcgcgccg ggtgtatcaa cgatcgtaat 1822801 ccctttttca gtgagcgggc atgtatagta gaccgttacc tctttcacag cacaggccgt 1822861 tgtttcctct gctacatacg gctttaattc agagagcgga atcgttaatt tcttctgttc 1822921 ctgtatatac tgctgatact tctcgtatgc aagcaggaaa ttgctgatca atttcacgtg 1822981 ttcttcctgc agcctgtttt ttttgactgc cttttcccac ttctctgtga aggaacggcc 1823041 tgccggctcc tttggtattc cggtgagctg caaaatttca gccgttaagt catcctctgt 1823101 cttaaacact acattcgctg ttttgtttaa gttgccattg attggctttg tgatcttgtt 1823161 aattgtcgct gtggttggcg ttggtgagga tggcagcact ctttcgccga caagcgcatt 1823221 ggcaaatgat gatttccccg agctaaagcc tccaaaaaga gcgagtgtaa atttccgttc 1823281 ctcaagcctt ttcacccttt cacgaaacgc tgaagtttgc tttaacaaca tgctgcattc 1823341 gcctaaaatg tcagacaaag tgtaaaagcg tttgatttgg tcttgaagcg gcatttcttg 1823401 ttccattttg atttctgatt tcggcatcgg ctgcgccgtc agctggcttc ggccttgttt 1823461 ctgctctgga gccgccactc ttgttttctt cgatttaaac cattctgtgt ctatatgcat 1823521 tgggcatgcg gactcttctt cccaaatggc ccacaggcga tcggttttct ctcgggcatt 1823581 attctctaaa cgtgcctgtt cttgaagaaa gacaagtttt tctgattctt ggacgagccg 1823641 gtcgttaatt gtttgcacat ctttggaaac acgctctttc accatagcgg agagcacctt 1823701 tatgatgtct gcggcttctc ttttcgcctc tttccggatg agctctgcca agtcttttgt 1823761 atattgcaat acatattcag aggaaaaggc tgcaccatgc ttgaccgcgt gttcaatgat 1823821 gcttatatca agcggtgtgc gataggcctg aatcagcttt tcactttcag cggtatagac 1823881 atcaaatacc ttggcgagtt tatgaagcgt gtctatcata tgccaatccg cttcggcctc 1823941 tgttcgtttt gccacatcag agaaaaaagc attccgcctt ttatctcttt cctgtgcagt 1824001 tttcgcttta gaaaagaaaa agccggtttt aaaggaaggc tcttgtgatt ctaaaaatgc 1824061 agccgccaat tcacgcattt caaaaggcgt caggttggcg ttttttaaaa tacgattgat 1824121 ttcttcctgc atcctcttct ctgcctcagt catttgtttt tcggcctcat ccaattgatc 1824181 acgcagcgat tggaccagtc cagtatggat attaagctgt tcagcgaaac tcggagcgcc 1824241 tgtttcgtct ttcttcagca tttccgtatg ttcctttagc agattacgga ctttttgttc 1824301 ggttaaagcc tgcatattgc tttttgattg ctgttctatt ctgcttaact cttctctcag 1824361 ggcccccatc tgattgaacg ggtgatccgg ttctgttact gatgtaaaat agagcgcttc 1824421 ccttgaaatc ccttcattgc aaagcatctc ctctacctgc gcttgatagt ctccaaattt 1824481 cgtctccgtc tcatcatggc ggtcaatttg attgacgata aaatacacat tcggaatgct 1824541 ttcttttatt gatctgagaa actttacatt ttcctcagcg tgcacgtgat tatagtgaac 1824601 gacgtaaaac agcgcatccg cttggtgaag aatagaagca gccgatagaa aatgcgcatc 1824661 atctgttgaa tctatccctg gagtatcaat atacgcaacc ccggaatcga tctcagtata 1824721 cctgtcaaaa atttcgacgc tttcaatctg ttccccgtct ttacaatatt gctgcacctt 1824781 gtctttctgg taagtccctt ccagctcagc acacgctccg tctgttgtat gaagccgaac 1824841 tcgcttttcc ccgtttctga tcacaacaag gttagcgctt gtcggaatcg ggcttgtcgg 1824901 caaaatattc tccattaaca ggcagttcag cagtgacgat ttccccgctg aataatgccc 1824961 ggtaaacgcg atataaacct cttcatcagc cgcttttttc atgaccgcag ccagtttagc 1825021 agccctttgt tcatcttgat tctcaataaa ttgcttataa agttccccgg ttttatgcaa 1825081 aagctctttt ctgttttgat ctgtcataag tctgaacccc tttgtgccgt ttcaattgtg 1825141 aacctttttc gaaagatctg aattcattcc cttttcattt tacacaagaa taaaccaaat 1825201 ttctttagga gaatagaaaa aagccgccat tacggcagct tctataaaag aaaatctgca 1825261 acttttacaa gttccagatt catcaaacag atttattaga gattcctttt aatacaaaac 1825321 caattaatac actatatgta caaaccgctc caagcaaaaa cagcattgtc atttgcttca 1825381 ccatcctgat tgagaatctt tttcaaaccc attttaacat ggttgagaat gattttcaat 1825441 cgctatttta cgctgtattc ctgtaatgct ttgtcttctg cgcgaattct gacgcttaac 1825501 aacacggcat tgaaaatgga aaacagacac atggtgacgt atgcttgata aagcagcgga 1825561 atcagcaaaa tttcgaggat aacaacggca tagtttggat gtttcatcca tttatatgga 1825621 ccttttttta caagctctac acctggaaca acaaggattt tcgtattcca atatgctcct 1825681 aaggaacaaa gcgcccaata ccgtacgatc tgtacgctta aaatcactgc agcgataccg 1825741 agccaccagc tggacggctg tttattcatc agcagcacct cggcaattaa ggacaggaaa 1825801 aaaaggatat gcatcgtaat gatatacgga tagtggctct cgccaaattc aattgctcct 1825861 tgcttcttta ccttttgttc gttttgcctg gccactgcca tttctgctgc tctttgaaca 1825921 atgagaatgg cgatcaacaa ccaaaacatg agtcaggccc ccttttccca gctgaataat 1825981 agcaactctg atgagaaacc cggccctaat gcgccaatca gtcctcgttc agcttccttt 1826041 ttatgtccgt tctgcagatg gtctttgatc acatacaaga ttgtggctga agacatattt 1826101 ccgtgctttt gcaaaatgct ttgcgcagat gaaagctttt ctgacgacag cccgagactt 1826161 ttgatgtatg catcgatcac tttttttccg cctggatgcg ccaaaaaaac actgatatca 1826221 tggaatgaca gcttatgttt gtccaaaaaa atctgtacat ttgttttgag ccatttttcc 1826281 accaaggtcg gaatgtctcg tgagaaaatg actttgaatc cttgatcggt aaagtcccag 1826341 cccatgacat cttctgattg tttcatcaaa acagattggg cgtccattat cttcggcgca 1826401 agcttcagct ttgacaccct gcggtccgcc ttctctccgc ataataaagc tgcggcaatg 1826461 ccgtcaccaa aaagcgaggt gccgatcaga ttgctttttg ttttatcttc cggctggaat 1826521 gtcaggctgc acagctcggc agaaatgaca agcacaaaag cctcaggata cgctttgcag 1826581 tattcggctg cacgcgcaag tccgctggct cctcctgcac agccaagccc ccaaatcgga 1826641 atccgcttcg tatatggaga aaacggaagt tcattcataa gccgcgcctc gatactcggt 1826701 gtggaaagac ctgtactgga gacgaaaaaa acagcttcca ctttctcata aggaatggct 1826761 tcttgaaaaa attccggatg agagaggcac tcacgaacag ccgctctgct gtgtttaagt 1826821 gtttcttcta tgtatatttg atttttttct tcaaagctgt gcccctcttt ataccattca 1826881 atcggcttaa caaactgtct cgaatggatt tgcccgtttt taaaggagga taacagcctg 1826941 tcaatatcct taaaagaatg ctgaaacata tagcgggcga actcggccgc tttctcttgg 1827001 tttacattat acgcaggaag acttgttcca atggataaaa taaacgccat gcgatcacct 1827061 ctttgcatac attgtgccgc aacaatcttt tttatatgca aaaaaaactc cgccgcggcg 1827121 gagttagact gctgtttttt gttcagcgag gtcagcttct tgttctattt ttttagcttt 1827181 agaaaaaacg ttatatacaa tatttaagac gactgcagta aagctgcccg ccacaatgcc 1827241 attcgttgta agcagcgtta aggcactcgg aagctgtttg aaaatatccg gcacaacggt 1827301 cacaccgagc cccaatccca ctgagcaagc aacaatcagc agattttcct gtttcgcaaa 1827361 atcaatgcgg ctgagcattt taattccgta agcaatcacc attccaaaca tcgccaccat 1827421 tgcaccgccc aaaacagcgg atggaataat agtcgtgaaa gcagcgatct ttggaaacag 1827481 cccaaatgcc attaggatca cacctgtgac cacaatgacg gcattttttt tgatccctgt 1827541 gagctgaaca agcccgacat tttgagagaa tgccgtgtaa ggaaaagcgt taaaaatacc 1827601 gcccagaagc acagccagtc cttcagctcg atagccttta gacaaatcta tctctgtcaa 1827661 acggcggttt gtcaggtcac ctaaagcaaa gtaaacacca gttgactcca caaggctgac 1827721 aattgcaacg atggacatcg taatgatagg cgctgcgtga aaagacggcg ctccgaagta 1827781 aaatggctga atcatttgaa caactgccgc gtccgaaaca ttatcaaatt gaacttttcc 1827841 cataaaatat gcgatgaagg tgccaatcaa aataccgatc aaaatcgaga cggacttgat 1827901 aaagcctttt gtaaaacggt atagaagcac aatgatactc aacacggtaa aagcaagtgc 1827961 aagattggag agatctccga aatctgcact tccttctccg ccggccatgt tattcatggc 1828021 aaccggcatc agtgtaatac cgataatcgt aacaacagag cctgtcacga ccggcggaaa 1828081 aaacgatacg agctttccaa agaaaaatga aataagaatg acaagaatgc ctgaagcgat 1828141 aatgctgccg taaactgttg aaaccccata ttcagatcca atcgctatca tcggcgatac 1828201 agctgtaaag gtacagccaa gcactaccgg aagcccgatc ccaaaaaatc ggttgctcca 1828261 cacttgcaga agtgtagcca caccgcacat aaaaatatca atcgatacta agtaagtcag 1828321 ctgctcgaca gtcagtccca ttgcttttcc gacaatcaga ggaacgacaa tggcgccggc 1828381 atacatggca agaacatgct gaatccctaa agacagcgtt ttgccgaatc catttctcat 1828441 gaatgaacct cctgtacgaa ggacactttt ccttcttcta aagactgaat tcttgccaaa 1828501 gattccactc ggtagcccag ttttacaagt tcatctcttc ccggctgaaa tgacttttca 1828561 ataacaatgc cgattcccgc aatagaagct cccgcttgct tcacaatcga cacaagcccg 1828621 tgcgctgcct gtccatttgc caaaaaatca tcgataatca gcacatgatc ctgatccgac 1828681 aggtgggtcc cagacactgc gatttggctt tctgtttgct tcgtaaagga ataaacagac 1828741 gctgtcagca agttgtcggt gagtgttaac gatttatgct ttctcgcgaa gacaactggc 1828801 acacccagct tcaagcccgt cattacagcg ggagcgatac ctgatgattc gattgtcaca 1828861 attttggtaa taccgtcttt tgcaaaccta gacgcaaatt catcaccaat tctctgcata 1828921 agcagcggat caatttggtg attcaaaaaa gaatccactt tcaatacctg atcagataat 1828981 acgacgcctt cttcctctat tttccgtttc agtgcttcca tcctgtctac ctccgttatg 1829041 agaataaaaa aagcattgcc cgctcaaata aagagcaagc aatgctgata tcacaaaaaa 1829101 ccgtacacgt gcggttccat tgctcaccca tagtcggaca tttacggtgc ccggtagaaa 1829161 cttgcgtgcc atatccacgc gattatatga gtgttcctat tatattgtaa taaattatat 1829221 caagattcta atctcttgca taggctgaaa ataaaaattc ccgaacttta attttgtttt 1829281 tttagatatc attcgtattt caaggggatt cgatataaaa gagtctgacg accgcgccgc 1829341 caggcttttg attataacag atagagattt gaatatttgt ttgataaata atcaattaaa 1829401 tagcgaacat tcagctcttc tcctgttgca tctttaataa tgtctaacgg ctttttccgt 1829461 tttccgtgaa tgtgcacctt ttccgtcagc cattgcttta tcggatggaa ctctcctctt 1829521 tccaagagag cgtcaaattc agggagatcc tcaagcattt tttgtttcag ctgagccgca 1829581 tacatgtagc cgagcgcata ggatgggaag tagccgaaat ctccacctgc ccaatggacg 1829641 tcctgtaaaa tcccctctgc gtcggtctgc ggtgtaatcc ctaaataatc ctggtatttt 1829701 tgattccaaa gcgacggcag atcttccaca gacacttcat tgctgaaaat cgctttttca 1829761 atttcataac ggatgatgat atgaagagga tacgtcaatt catccgcttc gaccctgata 1829821 aatgaaggtt ttgattcatt gattgcccgg acaaaatcat ccagggagat gtccttgaac 1829881 tgtacaggtg atgcctcttg aatcttctta tagtacggag tccaaaaatg cttgttgcgg 1829941 ccgataaaat tctcgtaaaa taatgattgc gattcatgaa ttcccatcga tgcgccgtct 1830001 gacaagttcg tgccactgag tgcttcatca atattttgct cgtaaatcgc gtgcccgcac 1830061 tcatgaatgg tcccaaagat cgccgtccgg aaatcttttt catcatatct cgtcgtgacc 1830121 cgaacgtctc cccgattcag cgtagttgca aacggatgaa cggtttcatc aagtcttccg 1830181 ccatcaaaat cgtagccaag ctcctgtaaa aaatacagac tgagctcttt ttgcttttct 1830241 ttcgggaacg cttttgtaat aaagcttgta tctggtttat ttccggaagc tgtcacctgt 1830301 ttaacaagag ggataatcgc ttccttcagc tcagcaaaca actgatcaag cacctttacc 1830361 gtgacgccgg gctcaaacaa atcaagcaat gcatcataag gatgctcttg atatccccaa 1830421 tacgtaataa aacgtttatt gaattcaatc agctgttcta aataaggaga aaacaagctg 1830481 aaatcagatt ttcctttcgc ttcctcccac gctgtttctg cctttgaaca cagaatcacg 1830541 tattctttgt attcagcctc agggattttc ttattctctt catactcttt tttcgccagt 1830601 tccactgctt ttttcgtatc ttccgacaag tcatcaaatc gttcatacag gacatcgata 1830661 agctccttca ttcgatctga tgtttggata ttgaatatat ctgttgaaag ctggccgata 1830721 ctttcggcac gatcctctga gccatttttc ggcgcgcctg ttctggagtc ccagtgcatt 1830781 aacgcaactg cttcgctgta atgtgagatt ctttttaaaa gatcaaaaaa ttctttttca 1830841 tatgtatgta tctccatatc cattccctcc ctattctagc cgttccatta caggctaatg 1830901 gaagggggta tgaaagtcaa attgtttgta taaaaggctg ccggtatgtt ttgtggcagc 1830961 ctttttattc agttgatcgt catttgattt tttggcggag gtgttctccg ctttttctgc 1831021 ttgatttttt tatctaccca cactgttgcc agcggggtta agagcgaggt gacaataacg 1831081 cttgtcgcga taattgcagt tgccgactca gcaactggcg caaatgaggc attcgcttcc 1831141 gctaatgcat atggcacggc tacagccgcc cctgccgtag aagaagcggc cactcccgcg 1831201 acaccatctc cccgcgcaat aaaacgatca agcaaaaaca aagaactgcc cgataaaatg 1831261 acgacagaaa ctccgataaa aatgccgagc agccctgatt ggatcagcat tccaaaattc 1831321 aaggtattgc cgagcgaaaa ggcgaaaaat ggaatgatcg ccggcacaac cttgctgaat 1831381 aagtctctga gatcatgatc cagatttcca agtatacatc caagtaaaaa cgggatgact 1831441 gtcgctgcca gcgtttccca tgggaatgcg gcaagtcccg tcacaccaaa cgtcaccatg 1831501 gtcataaaag gaccagattc tgtactgata aaggcgaaag cgcccgcatc ctcttttctt 1831561 cccatgtgat tcatgagcgc caaatacagt ccgccgttcg tttcattcat taccgcgaca 1831621 attgctaaaa cagaaaggcc tgcaaaaaag ccggattgta tgccatcgtc aggtataaat 1831681 tgcgctgcga tcacgccgag cagcgccgca aatccgatct tccccaataa taacgtgatt 1831741 ccttttcttg cgatatagcc tgaagaacga aaatcaatcg ttgctcctac gcaaaagata 1831801 aaaacaccca gtatcggcag cgttccggta atcaaagcac ccgtaaaccc tccaaagaac 1831861 tccgctgttc caggcgcaaa cgtgttgagc gccgctccaa gaaatagcgg aataatcatc 1831921 attccgccag gtacccgttc aattgtcgcc ttgattttca tattgtggat tctcccatcc 1831981 tccggttatg aaaaaacaat tccacttaca cttggaaaac agcctgcaaa tcctcttttg 1832041 aacagctgcc caactggctg ccgactccga cggcgccagc tccggctcta agccaatcag 1832101 gcacttcaga cggatgtatc ccgcctgtcg gaataaaggt cacctgcggg aaaggacccg 1832161 ctaaattttt cataaacgga atgccaaaca caccgcttgg gaacagcttt aatgtcgtaa 1832221 aaccgaatgt cagcgcttcc ataatttcgc tcggagtcaa gacgccgggg atataatgtg 1832281 tctttacaaa agatagatgt tcagcaagat cagctgaaaa acccggactg acaataaact 1832341 gcgcgccagc cttagcagct tccccagctt gctgcgcgct gatgaccgta cccgcgccaa 1832401 ttaaaatatc ttccctatta cggaaggatt cgataatatc tgatgccccg ggggtcgtat 1832461 acgtcacttc aactgcacga atccctttat ctaataaact ctcaatctgc tgacaggcct 1832521 cctgcttatc ctttgaacga atgactgcaa tcagctttgc ttctttcaga cggttttcaa 1832581 cgactttgga ctccatatta ataatcccct ttcttttggt gaaccgttct ttgagcagat 1832641 aaaaaagaag ctaatttctc cctggtcggc aaaccgtcca tatcccccgg tgcctgcact 1832701 tgcaaagcgc caatcgcatt tcccctttgc accgcatcct tgtacgacaa accgtctagg 1832761 ataccgctga ttacaccgac tgcaaatccg tctccggcgc cgaccgtatc aaccacccgg 1832821 tcgacccggc agccttctag aaatccttca cttgtccccg ttttaaagta agcgccttct 1832881 tttccaagtt taatagcaac aaagctggca ccttttttca aataatagtc ggcaatgcct 1832941 tcaggtgttt tttctccggt caatagctct ccctctgcga tacccgggaa aaaccagtct 1833001 gcaagcccag ccagatcatt gattgtgtgt accattgttg cttgatcagg ccaaagcgaa 1833061 ggtcttacat tagggtcgaa tgaaatggtc ttccctgcgt ttctcatgtc gttcatgaca 1833121 tgatacgtga agtctttcat ctcggctgat aaagcaggcg gaatacctgt cacatgcaaa 1833181 tggcctgcgc attgaaaata atctctcgga tattcagctg tagttaatgt gcttgcagct 1833241 gagtttttcc tatagtaggt aacttgcggg tcgccttctt tcacttttga cttcagcagc 1833301 agcccggtgg gattttcgtc ctgcgagcgg atcacgcggg acacatccac tccctctttt 1833361 ttaagctctt gtaaaataaa cgttccgagc tgatcattgc cgaccttgct catccatccc 1833421 attcgaaatc cgagtctggc aaggccgcag gcgacattgc tttctgctcc ggcaagccct 1833481 ttagaaaaag tggatacttc atgaaggcct ccatactcat ttgcataaaa catggccatt 1833541 gattccccga atgtcaccgc atcaagcttc atctcttccc aacctcctct tagttgaggg 1833601 cacctaggat taaagtgact ttctcatgat gacttttgcc tctaattcaa tggtttgagg 1833661 cgctcctttg tcaccttcaa tcctttttaa tacacgttcc atcgccgtcc tgcccatatc 1833721 atgtgacggc tgggcgatcg ttgtaatgcc tggaccgatc agtttgtacc actccgtatc 1833781 atcgaatcct gcaatcccta tatcttgagg gatgcgcagg ccaagctctt ccatacagct 1833841 gatgattttc agcataatca agccattcaa agccagaatc gctttttttt gctccggcat 1833901 ttccttgtga aaagaacgaa gctccgcctt aagctgctcc ttgtccttta cgtcaatttc 1833961 atgcaatctg acaagcccgt tcacattttg aaccgaagcc atttcctgat acacagctgc 1834021 tctttctgca cgagggctga tagaggaaat cggttcggta aacagcgcga catcagtata 1834081 ccctttgctg tacaccttct gaagaatctc ttttgtgatc catctgttgt cagtcgttac 1834141 ggtatccagt ttcagatccg gcagtttccg gtcaattaag attgttggaa tttgctgttc 1834201 agcaaaagcg cggagtacat ccttgttttc ccctgttgcg tttaaaatca agccctcaac 1834261 cgaatgggct tctagcttta agagcatttc ccgctctttt tcaggactgt tatctgtgtt 1834321 gcacaccata atgctgtatc catattgatc acaaacctct tcgactcccc tgaaagcagc 1834381 gaccgaaaaa ggatttgtaa tgtcagccac aacaaatccg attaacttgc ttttttttat 1834441 tttcaaacct tgtgccattt tactcggccg ataattcaat tctgcgattg cctttttaat 1834501 gtttttcact ttttcaggag aaatcgcgtc aatttttccg ttaatatagc gggaaactgt 1834561 cgatttcgaa actcctgcac attcagctac gtctttgatg gttgtatggc ctgttgtttt 1834621 ctttttcatt caagtgctcc tgtatctcat atatttgaaa ccgatttcaa aaccgttaca 1834681 acaaaagaat accataattt taaaatttgg gaagagtttt tttaataata tgtcaattca 1834741 ttattttttc gttgactctt ttcactattt atcctaaaat tttctttgaa accgttacca 1834801 aaatattttc attcaagtga tgctgaaatc ctaaccaagg gggaaatata atggaaaatc 1834861 gttattctgt acatcctgaa caagtaaaac gctttacaac agaggagctt cgcagtcatt 1834921 tcttaatgga ttctttattt acagaaaaca aacttacgat gtattactca catgaagacc 1834981 gggttgtcat cggcggagcg gctccagggc aaagtgaact gaagcttgat gcaggtgatt 1835041 ttctaaaaac agacttcttt ttggaacggc gtgaaatcgg gattattaat gtcggccagc 1835101 ctggtgccgt tagagtcggc gatgatgaat atgtgcttca aacaaaggat tttctctata 1835161 ttggaatggg caatcaggat gtatcgtttt caagcctgaa cggggaaaaa gcgaagtttt 1835221 acttcgtctc cgcttgcgcc cacaaaagct atccgacaca aaaagccgcc ctatctgaac 1835281 tgacaccgga ccgccttggt gatgatgcag cgtctaatgt cagaagtctg tacaaagtca 1835341 ttcatcagga tggcattaaa agctgtcagc tgatgatggg aataacgatg ttagatcaaa 1835401 acaacaactg gaataccatg ccagcacacg ttcatgaccg tcggatggag gcttatcttt 1835461 atctggatct tgaaaaggac tcaaaggtat ttcatttcat gggccagccg gacgaaacac 1835521 gccatcttgt tgttggaaat gagcaggctg tcctttctcc cgcttggtct attcattctg 1835581 gcgcaggaac atcaaactat agctttgtgt gggcgatggc tggagaaaat tacacattta 1835641 cggacatgga tctcattcca atggatgggc tgaaataaga tgggttatct acatgacgcc 1835701 ttttcattaa aaggaaaaac agcgctggtg acaggcccgg gaacagggat cggtcaagga 1835761 atagccaaag ccctagccgg ggctggcgct gatattatcg gcacatcaca tacaagcagt 1835821 ctgtctgaaa cacagcagct tgtggaacag gaaggccgga tatttacatc ttttacattg 1835881 gacatgagca agccggaagc gataaaggat tctgcagctg agctgtttga aaacaggcag 1835941 atcgacatcc ttgtcaataa tgccggcatt attcatcggg aaaaagcgga agattttcca 1836001 gaagagaact ggcagcacgt actgaatgtc aatctaaaca gcctgtttat tctgacacag 1836061 cttgctggca ggcacatgct gaaaagaggt catggaaaga ttattaatat tgcctctctc 1836121 ctgtcttttc aaggcggcat cctcgttccg gcttacaccg cgagcaaaca cgctgttgcc 1836181 ggtttgacaa aatcatttgc aaatgagtgg gcagcgtcag gtattcaggt caacgcaatc 1836241 gccccaggct atatttctac tgcgaataca aagcctattc gggatgacga aaagcgaaat 1836301 gaggacattt taaagagaat tcctgccggc cgctggggcc aagcggatga tatcgggggg 1836361 actgcagtct ttttggcatc acgtgcttca gattatgtaa atggacatat tttagcagtt 1836421 gatggcggct ggctatcccg ctgacaaata aaaaagctga cgaacgatcg tcagcttttt 1836481 tccattacat catgtgcggt tcaacaggca agaccttttt gacctcatca atgatgcgtt 1836541 cattttctcc gccagcgtaa atgtgaatcg agccgctgtc ttgattcgag cgaatcaggc 1836601 gcccgatgcc ctgccgtaca cgtaacaaca tatatggcag atcaacttct tcgaacggat 1836661 cttttttcgc tccgttgcgc ttcgctgtaa atacaggatc gtgtggcggg aacggtaatg 1836721 accaaatggt aacattcttc aatgcgtcac cgggaatgtc gagtccttcc cataagtgaa 1836781 ctgaacaaag tactgtttct tcttcctctt ggaatttctc tactaagctg ctgatttcct 1836841 catcaccttc gaagaaaatt ggatacggca gctcccatgc cgccgacagc tctttaaact 1836901 cgtttaattc ttcaaaagaa gggaaaagca ccagcgttct tcctttgtat cgtttgattg 1836961 tttcaatcgt ttcagccgtt ttttgttcag cgtccatatc tgtttttgcg tatagattaa 1837021 tactcatttg ctcgtcataa tcataagggg aatcaacagt taatgacaaa taatcatgaa 1837081 tcccaagact gtcggcaata taatcaaacg aaccgccttc tgacagcgta gcagaagaaa 1837141 agatataagg aattttctta gaaaacactt tttcgccaag tacttctgct accgttctcg 1837201 gcatcacgac aaaggttgat tctgcttcct ttttctccag ccagctgatc gcatcctttt 1837261 gatatagaga taatgaatac gccatttgtt caacatattc ttccactact gacagttcgt 1837321 attgatcaat cgtatacatt tcagactcaa atacaagtgc ctcaccgatt ttatcaagta 1837381 aacggcaaag ctcgtccgcc gcctttttga cacgatggtc attttttatt tctaaacggt 1837441 gtgaaccggc tacttccttt gattcttcag aaagaacata gaaaaattcg tcgtttgcga 1837501 gaagcgcatc ttcaatcaat tctgcaaact cttctctgat gtcattttgc agcaatcgtt 1837561 ctaaaaacaa ttcaagagta gactgcttca ctctataggt tagcgctttt tgcgcagcaa 1837621 actctaacaa gtgcccctca tcaaatacaa ctgcactatg atcaggcaag agcggcagct 1837681 ggccctctcg tttgcgtgat tcttccgtcc acacatgctc catataaaaa tcatgggaac 1837741 aaatgattaa gtccgttgac ttgcggtagt aatctctgga aagtgtcaga ccgcatctgt 1837801 gtctcatatc acaagtcaga cagtcctgaa acgagtcgta gcttacgtca gaccactctt 1837861 cattcgatag atttgcgtac tgcttacggt cgccatacgg ataaaagcgc tgcatcgcct 1837921 gggactcgtg gacaaatgac ggtaacgact cataaagatc cagccattta tcatcatcag 1837981 aacgctgcat tgttttttca agcttcttca agcataaata ttgctcatgt gattttgaca 1838041 gccttgtatc aattttcaga tcaagatgct cagccagctt agaaatatcg ccctcttttt 1838101 tcaccagctg ttcaattaat gtttcatccg cacaagcgat gatggcaggt ttgccgacat 1838161 accttgcata gctgattgca aaaagaagat ataccagcgt tttccccgtt cccactccag 1838221 cttcggcgaa catgactttt ttctctttaa acgcccgctc cagctgaaaa gccataaata 1838281 cttgctcgtc ccgaagatca aacccttttt cgggaaggat atcgtaaaac acgtcaccaa 1838341 tccaattgtt caattcttca taaaaattct ttgttttcgt taaagaaaaa ggcaaacgtg 1838401 atgttgtcac ctagttccaa cccccaacta ttcgacattc agaccaccaa taatatcatt 1838461 ttccgctgat gaatacaata aaaaacttgg caatgccaag ttttttgcag tttacttacg 1838521 attgatcaca tgcgacgata aaaaaggatg gtctgttgaa taaatatgtt ctaccgcttt 1838581 ttctaaatca gtttgcgcat gcgaaatcac agacggagac gaatcagtcc cgagctcctt 1838641 cagctcgttt gctgttgcgt caagcgccct ttgaataaga ttaaaatgtt cgctgttcag 1838701 catgagatca cctctgatgg aaataatcat cattgtatgc gaacttttca ttttatatac 1838761 atgctttacc gcatgttatc accgaaacat gcacaaacta cacttgatat tccgtctccg 1838821 gattatccgt cttatcaaca atattctatc agggagtgat gttgacatga gttatagaaa 1838881 ccgattagat cagcattctg aactgtttca tcacaattgg acgcggccta aacgttcaaa 1838941 gtctcaagta aacggtcaca ctgaaatgtc ccaaaccaac attatattga gaagcaacgc 1839001 gaaagctcac cgttggtaac gatagaatag ggctgaaaga tgaaagaaga cgcatgcaga 1839061 gcgtcttctt tttatgcgtt ttctgttttc ttgcgctgcg gtcttacttt tgaccagtat 1839121 tgataataat ccgttttaat aaacccgtta aagagttttc gtttcttcgt tgcttttctg 1839181 ccatatgctt cctcaaagtt ttcatttgat gtcagcatat acacagacca agtatcaagc 1839241 ggctcgaacg cctgccccat ttctttgtac atctgctcaa cggctttttt ctcgccgaga 1839301 cgctctccat atggcgggtt gccgacaatt acgccaaatt ccagatttgt ggtaaagtct 1839361 ttgacctgca tctgtttgaa ctggattaga tctcccaatc ctgcttcctc tgcattttct 1839421 tttgcgattt gaaccatgcg gtggtctatg tcgctagcga aaattgtaag cggctgatca 1839481 taatttgcct tttcttcgac ttcaagccgc gctttgttcc acagatcttt accgatccat 1839541 tcccaatcct ctgatacaaa atcgcggttg aatcccgggg cgatgttttg gccgattagc 1839601 gccgcttcta tcgcgattgt tccggagccg cagaaaggat caacaaacgg gcggtcaggc 1839661 gtccaattgg ttaattgcac caaagcggca gcaagtgttt ctttaatcgg cgcaccgccc 1839721 tgatcgacac ggtatcctcg tttgtgaagg cccgtccctg atgagtccag tgtaatcaaa 1839781 gcctgatctt tcaataaaga tatttccact ttatactcag cacctgtttc ttcaatccaa 1839841 tcattggctt tgccggactg cagcttgagc ttttcgacaa ttgctttttt gacgatccgc 1839901 tgacagtcag gaacgcttgc aagtgttgat tttaccgatt ttccgatgac agggaatttc 1839961 ccgttttcag gtataaatga gcgccagtta atcgctttcg ttttttcaaa cagttcatca 1840021 aatgttttcg ctttaaaaga agcaacctga acctttatgc ggtcggctgt tctaagccaa 1840081 aggttcgcac ggcagatggc aagtgcatca ccttcaaaaa taactttccc gttatcaacc 1840141 ttgcattcgt atcctaaatc tcgtacttcc tttgcgacaa cagcttcaat gcccatcggc 1840201 gccgttgcaa ttagtgtata cttcttcatc gtatcaccct gtcttttaaa acttttctct 1840261 tttcaagata aaagctctcc ttatacggga gagcttgttt tcatcatttt aaatgtaagt 1840321 ggtctaacgt tctgtaagcc atgttttgtt ccatcgtact gcaaacggct catcacctcg 1840381 tactcaggcg gcaatcatct atctacagaa agcattctgt ccttctctcc gttgaattcc 1840441 gttaagaagg ttcccctacc aaaatttggg tttctcgctc gaggggttta ccgcgttcca 1840501 ctctcaccat ttctagtgag acttcgtcac tgtggcactt tcaaggatac tcagccatat 1840561 ccgaagacgt aggctttttt cctgccgtca gcctctaaag actgccctag cttatgactt 1840621 cgctaggcac gaacactacg ggcatctcag caccgtgcga gcatggactt tcctctacag 1840681 attcaagatc tgcagcgatt acccgaacgt taagaacatg aattattata taacaactga 1840741 ttacaattta caagcgccat ttttttcaag cgtgatcaat cataaagctt gctgccaaaa 1840801 acgtgttttt ctaagttaga cagccgtttt aaaatatcaa agtttgttgt gttagattgc 1840861 acaggctgtt ttttgctggc ttcttcaagc tgttttttca gctgcagatt ttcctgctgc 1840921 agttcttcaa tttcttgatg gaaggtttca taatccttaa taatcatatc taaaaatttg 1840981 tcaacgtctt cttgcttgta gcctctaacg cctgttttaa attctttttc caaaatttct 1841041 ttcgcagaaa gctttacttt atcagcaagc atctttttca cctcgtatcg tgaatcatca 1841101 catatatttt ttcagaaatc tgtacggttg tcaaatttct ctctcattgt tagtagctgt 1841161 cttcctccac tgtcactctc aagtcatcca ttgtaataaa gtagatggga tagccatcct 1841221 gttcgcgcct tttttccgct gtcccaagca tatacttagg ggagccttcc ttttccgggt 1841281 catataaaag cagaagcccg tcggacttat caatgaagaa ctgatttttt tgtttgaatt 1841341 gaagcgggct ttcataagga cggtgagtca ggcttgcttc atagtctgcc tgagccagaa 1841401 ctgcttcata ctgttcttta ttcggttctt tccagttctt ttcctgctcg taaaatggtg 1841461 tgatgacagc tacctttaag tcagggtatt cctcctgcaa atcatatgca gcttctgccg 1841521 cccacagctc aactccaagc tggcccgaaa ttaaaatcca ttctaatcct tcatccaaaa 1841581 aagcaatcag ccggttttta atggcttttt ttatgtaata cagcgccttg tcatcctgct 1841641 taaatatccc cagttcaaac ggtttatagc ccgttattgc caatactttc atcatttcac 1841701 ctgctttaaa aaatggggct cccgtgggcc ccatttgttg tgctgcattg tttacaccat 1841761 caagctgcac gttttccata ctagtagtcg cagcaaggtt ttcctgcttg aaaatgctga 1841821 tgcgtagccg ggtcaacatt tgagaaagtg tgtggaaagt agtgaacgtg ctgaaaatgc 1841881 tggtggttta cgtttgttgt atgctgtggg tgaatgtgcg gcacgatagt cttcgaaaac 1841941 gtatggtgtt cacagcaatg agtaggatgg acaattggcg ccatcatatg cggtctgcag 1842001 tgatgcatga taaaatcccc tttccataaa ctttattaca atactaagtt atgaaaaata 1842061 aggggtacat gttctgatgc aaagacctat tttaaaagtg tgcaattaag ctgtctttaa 1842121 agtttgaaaa cacaaaagca atcaaaaata ccacaacaaa gaacaagtaa aaaacaccct 1842181 tatacatacc aactctccct ttaaaaataa ctaacgtcat tttacaggat tcgccgctat 1842241 tctacaacaa aatcaatgtg aattcagcaa aaaaaattca tggcgaaaca agtcgtcttt 1842301 tgcgctttcc cggggaatat ttaagaggaa tatttcctct ttagccgggc aattctcaca 1842361 tgcagttttt cagtttcttt ctctgataag catgccgcat cgctaagcga ttgctctgct 1842421 acttgcaatg cttttccgaa ttcttttttc ttatgctcaa aatatttcgc gagctctatt 1842481 acagcagcgt atctgcactt ctggttttgc gagcgggaca gcttttccca aagcggcact 1842541 gcttcttcca agcggttttg ttttttgtac aggagcgata aatccagccg tgcactgtcc 1842601 tggtcctcaa acgatttttc tataagcctt tccaactgct tgatcgcttg gtccgtttct 1842661 ttatgagcca taaaccattt cgccatagca taggcttcac tgtgttcttt tggcgcatgt 1842721 gattctgaaa ggattttttt agacatatgg atgtacaatg aaatgagtga taacacatcc 1842781 atttcattat gatgcaggac accttttaaa agatccggct cttgcgcctt gataaaatga 1842841 aagtaaagca ttggcgccaa gtagcccggt gtgtcttcta gcctgcggat gccgagctcc 1842901 tctttttcaa ccgtgccaag agatacacgg tccattttgt gtttccacag gcgtctagct 1842961 ccatgcaaaa gatcaaagtg gccaaactcc ggaagcttcg gaagtctgtc acggatcaag 1843021 gtgtgccttg ttttcacctg cggccaatca aaggctttgc cgttgtaggt cacaagtgat 1843081 gtaatgtcaa cctcgcttaa aaagctttgg tacaaggcga cttcgttccc cggtttgggc 1843141 aaaagatgct gtttgactgt cactcggtct tcatatactc tcgcatgccc aagcaaaaaa 1843201 atggtattcc cagctccacc cccaagaccg gttgtttctg tatcaaagaa aaagaggttg 1843261 tttttgttat acccttttgc tgacaatgta tgcgacaggc cgctttgatt ccacagtgtg 1843321 atcacttcct caagctcaga aaagctgtat aacccatggc ggtgagaaag cggatattct 1843381 acttctctga tgaggcaata ttcatcttcg aagatgaaag gcttcatgcc aaaagcctcc 1843441 cactcttcta aaaacgggat gtcatcaaag tggttttctt gtttgcctgc ttctattttt 1843501 tgttctcctt cgtcgagcgc catgtgcttt ttcatccgtt ggagtttccc ttttaatgac 1843561 atatccggcc tccctcctta cgacatttga tccaacagct gcaaaattct ttcctttgct 1843621 tttatccctt ctatttccgt acctatacaa gacggacagc cgtcatgaca aggacaatgt 1843681 gtaatcagtt gtttcgccgc ttcattaatg tctgaaaaac gtttaaagac ttcctccgcc 1843741 aaaccgatac cgcccggata atgatcatat aaaaatatgg ttggcaatcc ggtatgggct 1843801 gctttaattt gagaaacaac atgaacatca tttcgatcac acatgatata cacagggaca 1843861 atatgctgca gcacattcga gatgccaaga agcagctgtt ccagtgtctt ttccccgatg 1843921 tcttcatccg ctgttttgat ttcgagccaa gctgcacttg tatgcagttc ttcttccggc 1843981 aaatgaatag gtccagaccc aatattttca aaagtggtca tttttatttt tttaaaaatg 1844041 gtcggcaggg cattgacagt gacgtctccg tagtgcaatg acgtacggct tttttctttc 1844101 gttttatcga tttctaatac cttcagctga actgccaggt ttgcatccgt ataatattcg 1844161 acatcgactt ttctgacata cgccttttta tggtcccaat cgagcttctc aacttgatac 1844221 tgaacgcctt catgcaaata aatcgcttca tcatgcaaaa gcgtcatcgc actaaaacgg 1844281 tccatttcac cgataatcct tacatttgca atatccgact gatcaactat aacgacattt 1844341 tcctgggagg cggaacgcaa actgatgttt gacgcaggga acgactcact tgcccaatgg 1844401 taccgttcgc cgttgcggtg aagaacagcc tcttcctgaa gatactcaag aatatcactg 1844461 acttccatgg ctccaaattc ttcatcagct ctaaaaggaa gctcataagc cgcacacttt 1844521 aagtggtcta ctaaaataat caaattctcc ggattgattc ttgcagattc cggcgaacga 1844581 ttaaagaaat attcaggatg ccgcacaata tattggtcaa tcggtgttga attggctacc 1844641 atgataatca aagattcacc gtgtcttctg ccggctcgtc ccgcctgctg ccaagcactt 1844701 gcaacacttc cgggataccc cgtcattaca cacacttgca gctggccgat atcaacacca 1844761 agctctaagg cattcgtact gaccactcct aaaatgtcgc cttctctcag tcctctttcg 1844821 atttctcttc gctctttcgg cagatagcct ccccgatagc ctctgattga ttttgttcca 1844881 atctcttttt tcacaagctc ctgaatatgg cttaaaataa tttccacccg aactctgctt 1844941 ctggcaaaaa caatggtctg cactttgttt ttaaggaact ctttcgccag ttcattcact 1845001 tctgcggttg cgctccttct aatattcagc ggtttgttca caattggcgg attgtaaaac 1845061 acaaaatgct tgcgtccgct cggtgcgccg ttgtcatcga ccagccgcat cggtttgcct 1845121 gtcagctgct ctcccaattc ctttgggttg gcaatcgttg cggaagtaca aataaaaact 1845181 ggatcacttc cataaaaccg gcagatccgc ttcagccgcc ggatcacatt tgccacatgg 1845241 ctgccgaaca cacctcgata cgtatgaagc tcatcgatga cgatatactt aaggttttca 1845301 aacaaactga cccatttcgt atgatgcggt agaatggcag aatgcagcat atcggggttt 1845361 gtaatgacaa tatgacctgc ttttctcacc ttttgtctga ttgccggaga cgtatccccg 1845421 tcatatgtaa agcttttaat atcaatgccc atttcatcaa taatttcatt tagctcgctc 1845481 ttttggtctt gtgccagcgc tttagtcgga aataaatata acgcccggtt tgtttcatct 1845541 tgggcgatgg actgcaggac tgggaggttg tagcataacg tttttcctga tgctgttggc 1845601 gttacggtaa cgatgctctc tcctttttgc acatattgaa aagcggaata ttggtgagta 1845661 tatagttcat caatgcccct tttcgaaagg gccgctttga ttctctcgtc tatactttcg 1845721 ggcataggcc ttgtttttgc ttcccgaggc tcaatttcat gccaattcac aacgttttca 1845781 tttcctttta aatcagaaat gagttcagtc agtgatttct ttttcattct ttacacctct 1845841 ttgtcaagta cagtttaccg aatatttgtt tgcatggcta ggtgcaaatt ttatacagtt 1845901 gaataaaaaa agcaaggcat acgccctgct tatttcgctt ttattgtaaa gagctttgat 1845961 tcgcctttac gagcagcctt ttcgcctgcc gataccattg atcctacagc ctcaccattc 1846021 attataacga ttgggatgac tgtgctgctc gctttttctt ttattaattc caaatcacat 1846081 gtaatcagcg ggtcaccgac cttcacttta tccccttctt taatgtgggc agtaaatcct 1846141 tctccgttca tattgactgt ctccagcccg acatgaatta acagctcaat tcccgagcga 1846201 gtccgaatgc caacggcgtg tttggtgtgg aaaatctgaa tgacttcacc ttcagcggga 1846261 gaaacgattt caccgctaga aggttccacc gctattcctt ctcccatcat tttctgtgaa 1846321 aaaacagggt ccggtacatc tgacaggtcc attactgtac cgtctgccgg agaataaata 1846381 acctcttctg tcaccttttc ctgaattttg cccattccga ataatttttt cagcaatgta 1846441 ttttctccct tctcattcac ttcaaccgtt atcccttcat tcaccactat ttaaccacac 1846501 tttcaatttt gcttcaattt ataacaacat ctggcataga cgcataatct ggttaaaaaa 1846561 ggcggtggcg atattggaat tccatgatga caaaaagaac gaactgcaaa agaaagaaga 1846621 aatcataacg gaggcaatcg acactctttt tcaatcctca gcgttcggca accttataaa 1846681 cggatttcag aacctaatca actcgagttt aaaggatgtg cagacgacca tacatgtcag 1846741 agaaagagat actgggctgt atatcgatat taccattccg gcgacgtttc gagatggcga 1846801 gatcgtcgtt gatgttaaat cgaggtatct ccatgtaaca ctccaagaaa aacagaaaca 1846861 ccaaaatgag gctaccttta caagcatgac aagaacggtt cagctgcctt atgaagttcg 1846921 ccaagaagat atggaaacgt cttggaacga gcagacaatg acacttttct ttccaaaaaa 1846981 taagcatgaa tgaacgattc attcatgctt ctatcattta aaaaagctgg taaatccctt 1847041 tattaaagat ccgacctgat tcattgcact cattacttga cctgtcgtat ccatcatttt 1847101 attaaaatca aattgcccat tggctttttt gaactgcgac ataatgcttt gaaattgtga 1847161 aggctgctgt tgattaggcc ttgggatagg ataagggtta gaaaatacag gcggctgcat 1847221 aggcataggc tggatcggag cataaggctg ataataatcc tgctgtccat aatgctgctg 1847281 aggcagttgt tgctctaaat aaccgggtgc agcctgctga taatatcctt gcatatgctg 1847341 aggataataa tagcccattt gccgaggata gcttcgagag ctcccgttca ttgcgattcc 1847401 cccctaaaca caacatattt ctcttctata tatgtatgaa tgacttctat tgtttgtgtc 1847461 acaagtgatg attagcattt gtcaaattgt gtcgaaagtt taaatttttt aaaaacagaa 1847521 aaaagtcgaa tcattatggt accatatttt caatacagat gagaggggat gcaccataat 1847581 gaacgtatca tacttaagca aacgttttgc agaaatgaag aaatatgaaa cagactgtat 1847641 gaataaactg atggactttg ccaagttcct ctatattcaa ggacatctca gcataactga 1847701 gtttcgtaac agtatgaagg ttctcgaagc aaatggagca gaaagcccgg catatgagat 1847761 gaattaacgt ccggccccct ataaaaacga aaagaagaca gccttttacc ggctgtcttc 1847821 tcttgcaatt tcatccttta ctgcgtgcaa tgtataaagg actgactcag tgatgtcctt 1847881 gaatcgtttt ttatgaatat gatgaacata agattgaagg accaattcca ggaaattatc 1847941 ctttacggcc tcaatttgct ctttatgcac atattttggc cggcggactt ttatcaattc 1848001 aagagcaccc tctgcccagc gagcagccag ttcatcattc tcttcaactg caggctttat 1848061 cgtctcaaaa aaatcataag aatgattact gttttttcct tcctgatacc gatcagcgcc 1848121 tttttcagca acttcaatca tttgctcggt catttccagc aaagtttgtg atagcaatat 1848181 ctttcacctc aatgcctatc gtaccaaatt tcactcacaa attcagccga tgcggtatac 1848241 cttctcaaac gcatacctgt gttcaggcga ttgatacagc tcatttatac aaatatgaag 1848301 atctatgatt tcttcttcga gcacacttag gcgatcgttc tccgtttccc gcatctcagc 1848361 ctctaatgca tttacagaat gattcaggct ttgctcagct cgcgttaatt catcttctat 1848421 atcagaaagc atacggagaa tatctgtctt gcatacataa ccggacattc gtgtacctcc 1848481 ctttccttgt ctctcccggt taacattctt tgctctcaag gctctttcct tcctcatgac 1848541 aaaactagaa gcaaatcgcc aaacaaacag gtattccacg aaaagctgaa gttttcgaca 1848601 aaaacacccg caaaaattgt atgatcctcc tcattaatgc aaacgatact tgtgaggagg 1848661 tgccgtatga aaacaagacc gaaaaaagcc ggccagcaaa aaaagactga atcaaaggca 1848721 atcgattctt tagataaaaa attaggcggc ccgaaccgcc cttctacgta agaagcaagg 1848781 aatttccttg cttctttatt ttttcagcca ctgctccacc gcaaaaagcg catgaagctg 1848841 gcgcttttta tgtaaatacc agtctgtcaa ttcaatctgc ttcggcaatt cctcgcgcct 1848901 aaagaacgtt ttctttatct ttccatgaaa ccaatctgtt ttcgttccgt ctaatgagtg 1848961 gattaactca gggtagcatg tccttagcat aggagatgtt ctttttgtaa tcccgatcat 1849021 cttttccata tcaaaacggg aacctgtgtg cggcactgtg tgcaaaaagt gataaaaaga 1849081 ggagaacaat tctggcttga acagcaattg agacagctgc tttcccagcc ttatcctttc 1849141 ctccgccttt gaaaagcgtt tcactgaaat gccgtaaaaa aacccatttg aggaaggaaa 1849201 aataacggtg ttaaaatgaa accagtcact taaataaaaa ggaatcgtgt caaaaacatt 1849261 ctttttaaac gaaggatttt gtataatagg tgtttggata gtgttttgtt catttataat 1849321 gagggcatac attagccgct ccgtatttcg ctcatgccaa aaacgggtcc attcttccga 1849381 cataaattgt gagacgccaa acacatgcag cagatgaaac agcggtttcc caactctttt 1849441 tgaccagtgg tataaaagaa gctgcggata ggcatccgaa aaaataagcc agttcgctct 1849501 ttcataggct aaaaagaacc atttttgctg tctctcacgg agtccaagct gaaacagact 1849561 gccttttaag tcagtcattg accagccggc attacgagaa acgaaagaag ccaaaagcga 1849621 ccatttgatt tccggatgac ggtcgtaaaa tgctttataa gcatttgttc ttgaaatgtt 1849681 atccgcgttt ttcatttttg tctgccgctc aatccggctc agaagctttc tgatggcctg 1849741 ttgttcttgc acgttcattc acttccgtca tgattagttt aataaggagg atgagaaagt 1849801 gattcggtat cctaatggaa aaacatttca gccgaaacat tcggtttcat cccaaaacag 1849861 tcagaaaagg gccccgtctt acagtaatcg cggaatgacc ctcgaagatg acttaaacga 1849921 aacgaataag tattatctga caaaccaaat tgccgttata cacaaaaagc cgacacctgt 1849981 tcaaattgta aatgtccatt atccaaaaag aagtgccgca gtgattaaag aagcttactt 1850041 taaacaatca tcgacaacag actacaatgg gatttacaaa gggcggtata ttgattttga 1850101 ggcgaaagaa acgaaaaaca agacctcttt ccccctgcag aattttcatg accatcaaat 1850161 cgagcatatg aagcaggtaa aggctcaaga cggtatttgt tttgttatta tatccgcttt 1850221 cgaccaggtt tattttttgg aagccgataa gctgttttat ttctgggaca gaaaagaaaa 1850281 aaacggcaga aaatcaattc gaaaagatga gttggaagaa acagcttatc cgatttctct 1850341 tggatacgca cccagaattg attatattag tattattgaa cagctttatt tttcgccatc 1850401 atctggtgcg aaaggttgat taacgaaagg ttgagatgtt atgtcagatc aatttaacag 1850461 ccgtgaagct cgacgaaaag cgaacagcaa atcgagtcct tcaccgaaaa aaggcaagaa 1850521 acgaaaaaag ggcggattgt ttaaaaagac ccttttcact ttactcattc tgtttgtttt 1850581 aggcgtagtc ggcggtgctg ttacatttgc cgtcatggtt tctgatgcgc cgtcccttga 1850641 tgaaagcaaa ttgaagacgc cttattcatc aacgatttat gataaaaatg gaaaagagat 1850701 cgccgaagtc ggcgccgaaa aacggaccta cgtctcgata gatgaaattc ccgatgttgt 1850761 aaaagaagcc tttatcgcga cagaagacgc tcgtttttat gagcaccacg ggattgaccc 1850821 tgtccgtatc ggcggtgcat tagttgccaa ctttaaagac ggcttcgggg ctgaaggcgg 1850881 aagtacgatc acccagcagg tcgtcaaaaa ctcccttctt tcacatcaga agacgttgaa 1850941 acggaaggtg caggaagtat ggctttcgat tcagctggag cgcaattact ctaaagatga 1851001 aattttagaa atgtatttaa accggattta tttttctcct agagcatacg gaatcggaaa 1851061 agcggcggaa gaatttttcg gcgttactga tttaagcaaa ttgactgtcg aacaggctgc 1851121 gacgcttgca ggaatgccgc agagcccaac agcgtacaac ccggtcaaaa acccggataa 1851181 agcggaaaaa cgacggaaca tcgtactcag tctgatgaaa aagcaaggat ttatttctga 1851241 ttctcaatat aacaaagcga aaaaagtggc agtgaaagac gaaggcgtcg tgtcacagaa 1851301 ggaatatgaa aaagcaagta caaacaaata cagcgcattt gttgaagagg ttatgaagga 1851361 aattgatgaa aaatctgatg tcgatccatc tgctgacgga ttaaagatct atacgacatt 1851421 agatacaaaa gcacaagata aactagatga attaatggac ggagacaccg tcggatttac 1851481 tgaaggcatg cagggcggtg tgacgcttct cgataccaaa aacggagaag tccgagcgat 1851541 tggtgcggga cgcaatcagc ctgtcggagg ctttaactat gctactcaaa ctaaggcaca 1851601 gcctggttcg accataaaac cgattttgga ctacggacca gttattgaaa ataagaaatg 1851661 gtccacatac gaacaaattg atgactcagc ttatacgtat tctaacggaa aaccgattcg 1851721 tgattgggac cgcaaatatc tagggcctat ctcaatgcgt tacgctctgg cccaatcaag 1851781 aaatatacct gctttaaaag cattccaggc agtcggtaaa gatactgctg tagactttgc 1851841 aaatggactc gggcttggtt taacaaaaga taatgtaaca gaggcctatt ctattggcgg 1851901 tttcggtggg aacgatggtg tttctcctct gacaatggca ggtgcataca gcgcgtttgg 1851961 aaataacgga acgtataatg aaccgcattt tgtaaaatct atcgaattta acgatggcac 1852021 gaagcttgac ttaacaccaa aatcaaaatc agccatgagt gattatactg cgtttatgat 1852081 tacagatatg ctgaaaacag ctgtgaagac aggtactgga cagcttgcac aagtacctgg 1852141 tgtagaagtt gcaggaaaaa caggaacgac taactttgat gataatgaag tcaaaaggta 1852201 caatatcgct agcggtggcg cccgagattc ttggttcgtt ggctacacac cgcaatatac 1852261 agctgccgtc tggacgggaa tgggagaaaa cgaggctgga aagaaatcac tttcagctga 1852321 agagcaaaaa gttgcaaagc gcatcttcgc ccagctcatc gccgatgtcg atgacggaag 1852381 cggatcattt gagaagcctg acagcgtagt ggaagccacc gtagaaaaag gttctaatcc 1852441 ggcaaaactg gcagggccaa atacgccaag cgataagaag ctcacagagt actttgttaa 1852501 aggcacagct ccttctactg tttctaaaac atatgagaaa gaagaaaaag aggaaacagc 1852561 taaactgtct ggtttaaacg tgaaatacga taaagacaat caatctttaa cgttaagctg 1852621 gaattacgac ggagatgcga cctttgctgt taagcaatct gttgacggcg gcagctactc 1852681 ggaaattcaa aacagctctg caaaagaggc agttatttcg ggtgtgcagc caggatctgt 1852741 atacaaattc gaagtaacag ccgtcagtga tgatggcaaa agtacagctt ccacatctta 1852801 tgaggtgcca aaagctgaag acgatgaaga taaaaaagac cagcaacaaa cggatgatga 1852861 aaaacaagat gatgagaaga ctcaggatga tacacaaact gatgattctc aaaaagatga 1852921 cggtcagacg gatcaagatc agacagatga ttcaacaaac gatcaagaca aaaaacaaga 1852981 caatacgaac accaatccgt ccgacaacaa taaccaagac caatcaaacg ataatgataa 1853041 cgacaacagt aacaaccagg atacgtcgga tggtgattcg aactctggta agaatgattc 1853101 aacaggttct gacacgaata aaaataaaac agacacatct aataaaacac aaacaaactc 1853161 atcatccatt gaaaaaacaa attaaacaaa aaagccgtca cctttggggt gatggctttt 1853221 ttggtacaca ataaaaaacc tcccgtttta acaggaggtt ttatcgattc atcgcatgat 1853281 atttataaaa atgctttttc atttcggtaa tcagctcatc aagctgaata aagcaatggt 1853341 attgggtcgg cttaagaaga ataaattcca ctcgttcagc ccaattaatc ggctttgcgg 1853401 gatatgattt ctccctcagt tcttgccaat cgagcgattt caccggctca cctgctgtcc 1853461 aatgtaacga agccagcaaa cacacaatgc cctttaacat ttcgttttgg tcacatctcg 1853521 attttcgtgt ttgaaagact gggagaagtg atgctttgat gtcatcccac acttcaaata 1853581 aaagcggaac gtatttcccg ctgtcctccc atggcaaatc gccttgtaat tccgtgcaga 1853641 aatcaaaata cacgggattg gtctgcaagg ttttcttcat atccgaggaa ctcttctggc 1853701 caagactgcg caagtattgc tcataggaag ccaacacttc ttttgcttgc gtcatcgttt 1853761 caccagtcct tttttatccc tcttctgccc ttctctgcac aaagaaagca gcggacactc 1853821 cgcacagcgc ggagattggg ctttacagtg atatctgccg aagaaaataa gccggtgatg 1853881 cgtaacggac caatcttctt tgggaacctt gcgcatcagc gtcttttcaa cttccagaac 1853941 cgagtccttc caccggcaaa tgcccaatcg tttgctgact ctctccacat gggtatctac 1854001 ggctatggcc ggcacgccaa acgcaacgga taccactacg tttgcggtct ttctcccgac 1854061 ccctggcagt ttgacaagct catcgcggtc tctcggcact tctccgccgt aatcttcaat 1854121 aatcatttta ctcagctttt gaatattttt cgctttatta cgatataaac cgattgattt 1854181 aatatcctgc tgaagctctt ccagcggaac agccaaatag tcttccggcc gtttatattt 1854241 ttggaataat gttttggtca ctctgtttac aagtgcatct gtacattgcg cagataaagc 1854301 aacagccacc actaattcaa aaggattgga atgaaccagt tcacactccg catgaggaaa 1854361 catgtcacct atcttgtcta aacagaattc aatttgtttt agatttaaca cgattgtcac 1854421 cttttcactt tattgttcaa gccaattgta aaaaggaacc tgccttttat actctttttg 1854481 cggttcattc tgctttgctt gtacacgccg gaatttttgg ctgtgtattt ttgcctgctc 1854541 cacagtttta agcccatttt tcttccattc aaacaaaatc cggtcaatgt agcggaaact 1854601 gagttttcct gatagtacag cctcttttaa cgcgtgtttg atcagttgtg cgtcatgctg 1854661 atcctggtcc tgccagatcg ccagcgtttc acactccaaa ggcgataacg gtcttgcgaa 1854721 ctcttcctca aaaatggtat aaaggctttt ttgttcccct tctgcttttc tttcctgtgt 1854781 ttgattctgt gcaagctgaa tatactcgta cagcttgccc cataaaggct gaagagaata 1854841 tttctcaaat ttgatgccgt tttgatcctc gcattcttca ataaacagaa agcctttttg 1854901 aataaacatc cgcaatctgt ttgtacattc ttcaacagaa attgacatac cttcctgcag 1854961 ctgattcggt gtaggaaaat atgatccttt ttctaaatgc attttaattt ttaacagcag 1855021 aataagttct gtttcattaa gcccaagctg tttataatgc gtgagcagaa gattggggat 1855081 ggttgatgtt ccctgctcct gcatatcaat aaattgctgt tttttcatcg tcacacctct 1855141 tactgtaaag gattgtgatt gcccctttac tgtaaaaagt ctcccttgca ggagactctt 1855201 ttttgtttca tttgaatgta ttacggatac agacggttta acagtcttgg gaacggaatc 1855261 gtttcacgaa cgtgaggcgc tccgctgatc caagctactg tccgctctaa tccaaggccg 1855321 aagccggaat gaggaactga tccatatttt ctaagttcag cataccattt ataagcgtca 1855381 gaatccagtc catgttcttt aagacgcgat tccaaaagtt ccatatcgtg aatccgttca 1855441 gacccgccga tgatttctcc atagccttcc ggcgcaatca agtcagcgca aagcacaacg 1855501 tcctcacggt cagaagccgg ctgcatatag aacggtttta aggacgtcgg atagcgagtg 1855561 atgaataccg gtttgtcata atgttcagca atcgctgttt catgaggcgc tccgaaatca 1855621 tctccccact cgatatcgtc aaagcctttt tctttcagaa attcaatcgc ttcatcatac 1855681 gtaattcttg ggaacggggc tttgatttgc tcaagttttg acgtgtctct tcccaatgtg 1855741 tttagttcaa ttttgcaatt tttaagaact gattgcacga tgaaagaaac gtaattttcc 1855801 tgtacttgaa ggttttcttc aaattctaca aacgccattt ccggttcgat catccagaat 1855861 tcgattaagt gacgctttgt tttagacttt tccgctctga atgtcggtcc gaaagagaat 1855921 acttttccta aagccattgc cgcagcttcc atgtagagct gtccgctttg agacagatat 1855981 gcatcttcat caaagtactt tgtcgcaaag agttctgttg ttccttcagg tgcgcttcca 1856041 gtcaaaatcg gcggatccac ttttacgaag ccttcgttat taaagaattc gtaagtcgcg 1856101 cgaatgattt cattacggat tttcatgatc gcatgctggc gctttgaacg cagccataaa 1856161 tgtctgtgat ccatcaaaaa ttccgttccg tgttcttttg gtgtaattgg ataatcggtc 1856221 gcttcgtgaa tgacttcaat atctgtcaca gcaagttcat atccaagcgg agaacgctcg 1856281 tcctctttga caatcccttt tatatagagc gacgtttcct gcgtcactga tttagctgtt 1856341 tggaaaatgc tttcttccac ttccgctttt actacgacac cctgaataaa accggtaccg 1856401 tcccgaagct gtaaaaacgc aattttcccg cttgaacgct tattagcgac ccaagctccg 1856461 atcgttactt cctcacctac gtgcttgtac acttggttga ttgttgtttt caacatattt 1856521 ccctccaaaa caagaaagac attcggaagc tcattgcccc gcgaactctt ttatcatcac 1856581 tttattatac ccgctcttaa ctaaccgggt caatgcagat aaaaagcggc ttttctgtca 1856641 gccgcttttt gatctgttag ctatgttttt ctacaaaacg cttgattctt tcaatggctt 1856701 cttcaagaag atctaacgat gttgcataag aaagacggac attctcagga gagccaaatc 1856761 cggatcctgg aacaatcgca actttttcct cctcgagaag cgctttaaca aattcatcta 1856821 catctttgaa accgcaagat tgagctgcct cttttgcatt tgggaacaag taaaaagcac 1856881 cttccggctt cacgcagctg aaccctggga tttctatgag ctttgcatag atcgtattta 1856941 atctatgttc aaatgcttct ctcatttctt ccaatggctc agaaggcccg ttataagcag 1857001 caatcgctcc gtattgtgcg attgatgtcg ggtttgacgt gctgtggctt gcaaggttcg 1857061 tcatcgcttt aataatgtct tcagagcctg ccgcataacc gattctccag cctgtcatgc 1857121 tgtgggactt cgatacgccg tttataatga ccgtttgctc tttcagtctg tctgacagct 1857181 gtgcaatgga aacatgtttc tttccgccgt atgtaagttt ttcataaatt tcatctgaca 1857241 caatcaagat atcatgttca aggcacactt caccgagcgc agatagttct tcttccgtat 1857301 acatgacacc agtcgggttg cttggagagt taataacgat tgcttttgtt ttttccgtaa 1857361 ttgcattttt cagctgctca ggcgaaattt tgaagtgatt ttcctcaagc ccttctacat 1857421 aaacaggctt tccgccagcg agtttcacct gctccgggta gcttacccag taaggcgttg 1857481 gaataataac ttcatcttct tcatccaaaa tcacttggaa aagggtatac agagcatgtt 1857541 tggcaccagt gcagacaata atttgagacg gtttgtattc aatattctgg tcgcgtttaa 1857601 atttctctgc aatgctgttt ttcagttcag ccaaaccacc ggaaggcgtg tatttcgtat 1857661 ggccctcgtt catcgaacgc acagcggcat caataatatg ctgcggtgta ttgaagtcag 1857721 gctcgcctgc tcctaagccg atgacatcat ggcctgcggc tttcagttct ttcgctttcg 1857781 ctgtgattgc cagtgtggtt gatggtgtta atgcggatac tctttttgcc agtttcaact 1857841 tgaactcccc ctaattcgtc ttaaggcgtg atatttttga gaatctttcc agttgtaaag 1857901 tccacataac ttaaactgta ttgcccttct ttgtctaagt acgtcacttc ccaaagcagg 1857961 acgtttcctt ctcttgccag atgaacctct ttttgctttg aaaccagccc ttcatccttt 1858021 atgattttcg ccgctttgtc ttcagagatt ccctctttcg cttcttttga gagaattttt 1858081 gcttttttat cagcaggaac ccagacatat aatgcagtgc cttttttatc cgttcccttt 1858141 acaacataat atttttcttt tccgacaaat gtttcgactt gatcaacatg ggcgagatcg 1858201 gtttcttttt tagcttcagc agctgctgct tcgtgcccct cttccttttg tgccatggct 1858261 gatttataaa tgcttgccga gacaagaagt actgctaaaa aaataatacc aaaaatgacg 1858321 gtaaatatta atgctttttt tctcatcttc tcacctacgt acgataaatg gtaaaaacgg 1858381 cttggttttt gttttcttca tccagcgcaa ggccgaacat cagattgtct cttttcagtg 1858441 tacgattcaa tgtgtccaca attttataca gatcatcaga atgctctaca ttaattgttg 1858501 aaagaatttc gattttactt tccatttttt catcctccag tttgaacaaa tattgttagt 1858561 catactccat ttcaggacac gccatactag tatcacagag cgggaaatcc gcttttaaat 1858621 aaaacaccat cctactccca caccgcaaaa gccgctttat gcggctttta ttctttttcc 1858681 cctgcaacat aagcttcaag ctcgctgtca gtcatttcgg atactgaggt tgtcggcaag 1858741 gcatcaagaa acagccggcc gtaaccagcg gttttaatcc gtctgtccaa tataataatc 1858801 gttcccttgt ctcccgcaga acgcagcaag cgtccgattc cttgcctgaa ggtcagcaca 1858861 gcttccggta atgacactgt ttgaaacgga ttctttcctt ttttgcgggc aagctcacat 1858921 tttgcagcat gaagcgggtg atcaggggac cggaatggga gcctcacgat cattactgtc 1858981 gtcagctcat caccagggaa atcaacgcct tcccaaaaat gatttgttcc gagcaggatc 1859041 gcctgattgg atgttttaaa agtcttcatc agtttgccgg gacttccgcc tgtaatccct 1859101 tgtgccaaga gctgaatgcc ggaagcactc atgttatgct taagctcctg gtgaaccttt 1859161 ttcagcatat catgggatgt aaacagcaca aggattttag gctgtttttc ctttgccatc 1859221 agttcgatat aacgggctgt atcctgtata aattcaggtt gccctgtatc ctgaattgat 1859281 ttcatttctt ttggaatcat cacctgcata cgctcatcgt aagaaaaggg tgactcaatt 1859341 ctcattgtcc gcgggaaaaa gtcactcagt cccagtcgtt caatcataaa ttgaaaagaa 1859401 ccttcgactg taagagttgc agatgtcagc accacactat ttttgcgcgc gaaaaactga 1859461 tcagccagaa gttcaccagg ttcaagaggc tgtgcgtaaa tggccactgc atttttcgca 1859521 ccctttgcat ctatttcaat ccaaaccgct tcatcgtcat cagagccaaa gaagagcttc 1859581 tgcaacgtct gacagtaatg ctgcaagcct ttcatgcttc tttggtattc atcggctaaa 1859641 aagacggttt tgctcttcat gcccttcaaa tgtttttcca taagggatga ctgcgcctca 1859701 aaaagctgct gcaaatgtgt cagcatggaa caaagcctct ccgcaccatc tgttaagatc 1859761 gaccagcttt tatcctggct ttctttgttc accttaaaca ctagacggtt taagtcttct 1859821 ttaggttttc ttcgtttgac aaaagaatgt acagagctaa agaaagcatc actttctgct 1859881 tgaacgtgct gaagccactc ttccaattcg aaaaatgaat caaccggcag gctgtttcgc 1859941 tggaatagct gtctcatctt ttttagaagt ccctgctcct tcagagtgcc gattctgctc 1860001 aatttcgtat gcaattctat gtacgtggct cttttcccta aatgttcgct tgccgcacgt 1860061 tcaaaatggt gtgcttcatc aataataaat gtgccgcttt cgggaagcct ttttttatgg 1860121 ctgccttcat cggtcagcaa aagagaatga ttggtgatca ccaaatcgga acgcatagca 1860181 atctgtttgg cccgctcgta aaaaccgatc acatgctcac tgcgacttct tttataggag 1860241 tcatcgtcat aagccaatct gtcccacagc aattttccgc ctgaaggcaa attcagttcc 1860301 gctacatctc ctgtatttgt ctctgtcagc caaacaagaa gctgtgcctt tgtcagtacg 1860361 gcatcataat tatcatcttc ttcatgaagc acctgctcaa atttatacag gcataaataa 1860421 tgcgattgcc cttttaaaat cgccgctgtt accggaaatg gaaacagatc ttggacaatc 1860481 ggcaaatcct ttgtgagaat ctgctgctgt aaaagcgtcg aatacgtgct gattatgacc 1860541 ggcttttttg atttcttggc aaaaagcgca gccggaataa gatagccaat cgtttttccg 1860601 atgcctggag gagcttcaat cagcgcatgc tcacgattgg caaacgcatc agccacctct 1860661 ctcatcatca tcatttggcc gtctcttttt tcatacccag gcattaactc tgacagcgct 1860721 ttttcatttc ccgcttccca gctttcgatc tcaaatgaga agttctcgtc ctcatttata 1860781 cgaacatcga tagcttcagg ttctctgaca gaaaacgaag aaaagcgcgt atagcccggt 1860841 atctcggtat gtctgttttc attaatgaac atatccaaca aatgcgtcag atcactgatg 1860901 aaatgctgcg aaagccttct taactgcttt aatgtcggat aaggaagctg ccgcagcttt 1860961 tcaaggattt ccaaaaaaat aagccctgtc acttcagcat cgctgtcagc ccggtgcggc 1861021 tgatcatgcc gcagctgaag ctcctcgctt aattccgtca gcttataccc ttcaaatccc 1861081 ggaaaaacaa tgcgtgagag ctcgacagta tcaagcactt cacaatctgg gagctgaaag 1861141 cccgccttat gtagctcata cttgacaaat ccaaggtcaa aatggatatt gtgggcgaca 1861201 aaataagcgc cgtcaagcaa ttggaatact tcttcagcaa ctgcttcaaa tggctgttca 1861261 ttctcgacca tttgattaga gattccagta agctgctcaa taaaagcagg gattgattta 1861321 tttggattaa tgtattttga aaaccgctca gtaatttgtc cattttcgat tacaaccgct 1861381 gcgatttgta tgattttatc gcctttcttc ggcgaattcc ctgttgtctc tacatctata 1861441 acaacgaacc gttgcttatt cattaaaatg gacacctcaa ttcttgcata cgacaaaagt 1861501 gtaacacgtt ttgtacggaa atggagcggc aaaaccgttt tactctcaaa atcttaaaag 1861561 aaaacccccg ataaaggggg cttttcttct acaaaattgt acgggctggt tcgttcccca 1861621 gcatttgttc aattttgttt tgatcattca gaacagccac tttcggctca tggcttgccg 1861681 cttcttgatc agacatcatt ttgtaggaaa taataatgac cttatctcct tcctgcacaa 1861741 ggcgtgcggc tgcaccgttt aagcatatga cgccgcttcc ccgtttacca ggaataatat 1861801 acgtttcaag acgtgctcca ttattattat tcacaatttg tactttttca ttaggaagca 1861861 ttcccacagc atcaatgaga tcttcatcaa ttgtaatgct tcccacatag ttcaggtttg 1861921 cttccgtaac agttgccctg tgaagtttgc cgctcatcat tgttcgatac atattatatt 1861981 ctctccattt ctcgaatatc aataatgata ttatctatta aacgcgcttt tgaaaaagca 1862041 actgcaacag cgagaatcat ctttccagca atttcattca caggctcgag ttccggatag 1862101 gaataaagct ctacatagtc tatggttccg ctagtcgttt caatgatatc ttttgcagct 1862161 tttatcaccg cttcaggatc tctttcaccg gcttggacaa gttccgcact tgtttgaagg 1862221 gcccgataca gcttaggcgc ttcttttctt tcctcagctg ttaagtatac attgcgagag 1862281 cttttggcta agccgtcttc ctctctgacc gtatcgacag gaaccaattc aatatccatg 1862341 aagaagtcgc tgattaaccc atcaacaaca gctacctgct gcgcatcttt taaaccgaaa 1862401 taggcacgag tcggcttgac tagattgaaa agcttcgtca gtacgatcgc gaccccgtca 1862461 aaatgtcctt ctcttgagcg cccgcataac acgtctgtgc gtctttctac atgaatcgtg 1862521 acattctttt caccgggata catatcatga gcatctggcg taaaaagaat atcgactccg 1862581 gcgttttctg caagagctgc atcccgctca atatcgcgcg gatatgcttc aaaatcttca 1862641 ttagggccga attgtgcagg attcacaaaa atactcataa taacggcgtc gttttcttgt 1862701 cttgctttgt ctgctaaggt taaatgcccc tcatgcagaa accccatcgt cggaacaaat 1862761 ccgattgact tgccctctga atggtattgt tttatggctt ctttcagctg tgaaatatca 1862821 gtaatctgtc tcatcttatt ttcccccgta caagccgtca agcactgtct ggttcatttg 1862881 aaaggaatgc ttttgttcag ggaaagcacg atgtcttaca tcctgaacat atccgctgat 1862941 tgctgtttcg atggtttcat caatgcgcgt atattgcttt acaaatttag gtgttctctc 1863001 aacaccgtgg ccgataatat catgataaac gagaacttgt ccgtccgctt tcacaccagc 1863061 cccgattcca atgaccggta tgcttagcgt ctcggcaatt ttggctgtga gttctgccgg 1863121 cacacattcc agcacaagca tcatagctcc tgcttcttcg cattttatac tgtcttctat 1863181 taattttttg gcgctttgtt cgtctttgcc ctgtacttta tagccgccca gtacgccgac 1863241 tgactgcggt gtcaaaccta agtgactgac tactggaatg cctccaagcg tcaatgcgcg 1863301 aatggattca aacacgcctt ctccgccctc aagcttcagt gcgtcagctc cgctttcctg 1863361 aacgatagcc gctgcatttt tcagcgtatc ttccttagac aggtgataag acataaacgg 1863421 catatctgtc acaataaagg tattcggcgc acccctttta acggcttttg tatgatggat 1863481 catgtccgca actgtcacac cgacagttga atcaaggccg aggacgacca ttccaagtga 1863541 atcaccgact aaaatcatgt caactcccgc ttgttcagca agtttagctg ccggataatc 1863601 ataagcggtc agcatgacaa tcggttcttc agactccttc atttttagaa aatccagttt 1863661 tgttttcatg ttttctcctc ctcatgttta gaggagatga tctgccgttt tcttctgcaa 1863721 gccaaaaaac cttccgttac aacgagaagg attcttcact ttctaaagtt cggcgagttt 1863781 catccctctg tcccagtcct tttttggatc aaggcagact gctgcaatgt ctatctattt 1863841 taataatagg tgcagttcgc aggcgatact gcccaatgga agtataccaa aatcaacggg 1863901 cttgtaccaa cacattagcc caattcgata tcggcagaat agattttttt aatgccttcg 1863961 ttcgtttcta aaagcagaac gccttcatca tctataccta acgccttacc gtaaaaggtt 1864021 ccgtttaacg ttctggctct catattagtg ccaataccga gcgcatagct ttcccataaa 1864081 agcttaatcg gcgtaaatcc gtgcgtcata taatcccggt accgtttctc aaagcatagt 1864141 aaaatatgct ggatgacgcc ggcccgatca attttttccc cagcagcttg gctgaggctt 1864201 gtcgcgatgt ccttcaattc atctggaaaa tcattaggct gctggttaac gttaatgccg 1864261 atcccaatga tcactgaacg tacgcggtct tcttcagcct gcatttccgt taggataccg 1864321 actgtttttt ttccgttaat caaaatatca tttggccatt taatatccgt ttggatgcct 1864381 gctgcctctt ctattccctg cacaacagct actgcagcaa gcagagtcag ctgcggtgtt 1864441 ttttggagcg gaatgtcagg ccgcaaaatc aggctcatcc aaacaccgtt tccttcttga 1864501 gaatgccata ccctagacat tcggcccctt ccggctgttt gtttgtcagc caccacaagg 1864561 gtgccttccg gtgcgttatt attcgcgagc tcatgagccg ttttttgcgt gcttgaaaga 1864621 acgtcatggt aaataagatg ctggcccatc acttccgttt ttaatccaaa acgaatttcg 1864681 ctttcactga gttttccggg ttttttgatg agccgatatc cttttcttct aacggcttct 1864741 acttcataac cctctttccg aagctcttca atatgcttcc acacagcagt tcttgaacag 1864801 ccgagagcat cactgatttt ttggccggaa ataaattcat tgccggcctg agaaaataat 1864861 tcaataaggt cttttcttaa tgttgaccgc atgtcttcag ccactcctct atgtgtttct 1864921 tttgattgga gagcttccct gtcacaacag cctgctcgat ccactgtaat tcttctgaca 1864981 cccattttcc ggccggccgg tttcgaagcg caagcaagtc cttacccgtg atatcaagat 1865041 ccttaaggct tttgatcggc aggttttgat aagcgtactg aatgtccttc agtttctttt 1865101 catccagttt ttcgttttgc cgaagctgcg atattttggc cgctgagagc agtgcttttt 1865161 tcccagctct gtacattgtc attgcgtcaa ggctctggcc aaacgtatcg gcaatgtgaa 1865221 tggcttcctt gatcactttt cccgggagct tccaggcttt caggaaaagg ggcgcgtctt 1865281 tcaaaactat gccaaggtta attaaaagag cagcccaaag ctcctcacgg gatgttaaag 1865341 agaagaatgg aaactcactc gttgaaatca ggttttctcg tttatgataa aaaccaggaa 1865401 gctcttcata caatctcgtt tgaatgagtg tttgaagcgc ctggcgagaa gctcttccct 1865461 gcagcaattt ctcaaactct atagtttttc gttcgactga aacatgggag aggagtgatt 1865521 tttctttcgc aatggcttct tctgtttccg gtgaaagcgt aaagccaagc tggctcataa 1865581 agcgtacggc tctcagcata cgaagcgcat cctcttgaaa tctatcctca ggctttccaa 1865641 cggttcgaat cactttctga tcaatatctt tcttgccgcc aaaataatca agcaccttcc 1865701 cgtccgctgt catggccatc gcattgatcg ttaaatctct gcgttttaga tcctcttcta 1865761 atgatgagat aaattgcact tctgacggtc ttctgaaatc aacataatca gattcagtcc 1865821 ggaatgtcgt gacttcatag gtttcatcct cccagagcac aataatggtc ccgtgctctt 1865881 tgcctacatc aacagtccgc tgaaacagcc gttctacttg atcaggtgcc gcatctgtcg 1865941 cgatatcgac atctccgatc gttcgtttca tatagctgtc acgaactgcg cccccgacaa 1866001 aataagcctg atggcccgct tcgattaaga tgcggagcac gggaagtgct ttgataaaaa 1866061 ctttttccat gtgatcactc cggttctgct aaatcggcat aaatctgttc atactggctg 1866121 acaatttttt tagaagaaaa ttcattttca agcatctcta ttgccgcctt tgtaaaacga 1866181 ttgcttagct gttcatcttc taaaatgctc atcgcgcggg ctgttgcggc cgtaacatca 1866241 ccgacatcca ccaaaaatcc gctcacattg ttttttataa cctcagggat accgccaatg 1866301 tttgttccaa tacaaggcac tccgcaagcc atcgcttcaa gcaggacaag gccaaagctt 1866361 tctttttcag atagcagcag cttcaaatcg ctaatagaat aaagatcttc aacacggtct 1866421 tgatttccaa gcattaagac ttggtcttcc aagccatatt ttctgataag ctcgcaggct 1866481 gtcgatttct ccggaccgtc tccgactaaa agcagcttcg ctttcgtttt gccagcgata 1866541 ttgcggaaca cacggatgac atcctgcacg cgtttaactt ttctgaagtt ggacacatgg 1866601 atgacgactt tttcatctgg taaaattcca tgtttctctt taattgccgc tgtgtttttc 1866661 ttcagataca cgcgctcgtc tataaagtta taaatcgttt caattttttt ctccggttta 1866721 attaaatcgt atgtttcagc cgcaagcgct gaggagacgg ccgtcaccct gtctgatgac 1866781 tcaatagcaa aacggatcag atcttttaga gacggatcat aacctaacac cgtgatatcc 1866841 gtgccatgca aagtggtaac aatgccgata ttgcgtttca gcatttgttt tgcaagatag 1866901 gcgcaaacgg catgcgggag agcatagtga gcatggataa tgtctaaatt ctcccgttcc 1866961 gccacctcag cgattttgct tgccaatgtc aaatcatacg gaggatactt aaaaacagca 1867021 tattgattaa cctcaacttc atgaaaatga atattgggat gatatgtatt cagtctaaac 1867081 ggaatgcttg atgtgatgaa atggatttca tgtccctttt cagcaagctg cttccccagt 1867141 tctgtcgcaa tgatacctga gcctccaacg ctcggatagc atgtgattcc tatttttagt 1867201 tttctcattg ttcgccccca agcacatcat gatcaagcat cagcatccgt ttggaaaaga 1867261 aaccttcggc atactccacg cccgcttctt taccgtaaag cttttctctc gcttcaacga 1867321 tttcaatata cccattcgtc agaggagtag aaacggaatc ctttgacggg ataaactggc 1867381 ttttgtaggc gttgaggctt tgtttctttg cctctattgt atccgagata tcaataacaa 1867441 aatccggctg atgaaaacca tttatcatat aatagtaaac cttgctgact ttatgcgccg 1867501 gaaggctttt ttcgtcttta tatttatgga ttccggcgga aaagatcgct tcttccacca 1867561 gtgcagccgc attgccgtga tccggatggc gatccttttt atacggcata aaaaccgctt 1867621 ttggccgaca gattctgatg acagtgacaa ttgaccgaat tgcctgatca ctcattatta 1867681 ggccgcggtc tggaagcgtt agctgaattc ttttatctgc gcctaatatg cgggctgctt 1867741 cagctgcttc ttctttacgc aaactgaccg taccgttaga agagagttcc gcttctgtca 1867801 aatcgcatat cattactttt ttttcctgtt tgacaaactt cgctattgtg ccgcccattc 1867861 cgatctcgac atcatcactg tgggcgccaa aagcaagaac gtcagcatta tacattcggc 1867921 tcttctcccc gaagaaggtc acggaattcg aaaacacctt catcaagtgt gcgcacaaga 1867981 atttccgcag tacccatatt tgtggcgagc ggaatggaat acacatcaca taaacggatt 1868041 aatgccgaga catccggttc atgcggctgc gcggtcagcg ggtcgcgcaa aaaaatgaca 1868101 agatcgagtg cattggcagc gatcagtgca ccgatttgct ggtctccccc taaagggccg 1868161 gattgaaaac gttcaatttg aagacctgtc gcctcatgaa ttttcaaccc tgtggttccg 1868221 gttgcgtata gatcatgatt ctttaaaata tcccgatagg cagtcgtaaa ttgaaccata 1868281 tcctgttttt tcttgtcatg cgcgatcaaa gcaattttca ttgtttatcc ccccgtctaa 1868341 tcaatgatat tttctaaacc atacacaagc tgatcaatct tcatgacttg ttcgactgac 1868401 agtttaacgc ctgacatgaa agaagcacgg ttataagaat catggcgtat ctgaagcgtt 1868461 tggccatcca tgccgaacat gacctcctga tgcgcgatca gtcccggaag acggacgctg 1868521 tgcaagcgaa taccgttttg ctccgctcct cttgctcctg ggagaatttc tttttcatcc 1868581 ggatgtcctt gctgcttttc tttacggact tctgaaatca tttccgctgt tttaagcgca 1868641 gttccgcttg gtgcgtcaag cttctggtca tgatgaagct caataatctc aacatcctca 1868701 aaatagttgg cagccatttt tgaaaatttc atcatcagta tcgcaccgag cgcaaaattt 1868761 ggcgcgatga tggctccgat ccctttttct tctgttaaag atgtgagctc ttttaaatca 1868821 gcttctgaga aaccggttgt tccgacaact ggacggactc cgtgctctaa tgcaattttt 1868881 gtatgtactt ttccgatttc gggcgttgtt aaatcaatca agacatccgg ttgtgtttct 1868941 gtaaaacagg catggatatc tgtgtaaatg aaagcatctg actcaacagg catcacatca 1869001 gataattttt gctgatcgta tgtatggtct atggccccta caaggtcaaa atgtggtgtt 1869061 cgttctgcca atttaacagc ttcctgcccc attcttccac gcggtcccgc aatgactaat 1869121 ttaattgttt cgtttgacat cttgatctcc tctactttcc ttcttctttt ctggtccagc 1869181 gatctttatc tcttgtatta aatttatgca tgactcggtc gtgagcttcc tctaaagaga 1869241 tatcaagaga gttggctaaa caaaccaata caaatagcac atcgcctatt tcctcttcca 1869301 tgcttttatc atcttcagtc gctttttttg gtttttctcc ataacggtga ttcacttctc 1869361 tggcaagctc gcccagttct tcagtcagcc tcgccatcat ggccagcggg ctaaaatatc 1869421 cttctttaaa ttggcctatg taacggtcta cttcagcctg tatgtctttc attgttttat 1869481 cactcactga acgaaacctc ctatcatcct cttacatgtt agctaattca gatacgtttg 1869541 acaaatgttt aagcacgttt gctgttttct ttttcatcca ctataatata aacgctatct 1869601 aatggaagga aaaggggttt tgtgtgatgc ttggagaaat tagattaaaa aacatatttt 1869661 ttattttaat cggagcggca attttttcat ttggcttggt tcatttcaat atgcagaaca 1869721 atctggctga gggcggtttt acaggtatta cacttttgct ttatgccctt ttccacatca 1869781 gcccctctat atcgaacctg gtgttgaaca ttccgatttt ttttattggc tggcgtttgc 1869841 tcggcaggac aatgtttgtt tatacccttg tcggcactgt agccttgtct ttgttcctca 1869901 gcatctttca gcgatatgaa atccatatgc cccttcagca cgacttagcg ctcgccgctt 1869961 tatttgccgg cgtattcatc ggagccggac tgggtattat ttttaagttc ggcggtacga 1870021 caggcggtgt tgatatcatc gcacgtttag tgaataagta ttttgggatt ccgatgggca 1870081 gaacgatgtt tgctttcgat gcctgcgtca tcattttgtc tttgcttact tatctctcct 1870141 ataaagaagc gatgtatacg ctggtagctg tatttgtagc ggcaagatta atcgatttta 1870201 ttcaggaagg cggatacgct gctaaaggcg ctacgatcat ctcttcgaaa aacgacctga 1870261 ttcagaaaaa gattcttgaa gaaatggaac ggggcgtcac cattttgaaa ggacaaggtt 1870321 cctacacaaa agaggatata gatgtacttt attgtgtggt gccgaaaaat gaattggtga 1870381 tgctgaaaag cgtgattaac tccattgatc cccatgcctt tgtagcggta agcgatgttc 1870441 acgatgtgct cggagaagga tttacgcttg atgaaaataa aaatccgctt ccgcgctgac 1870501 atgtaataga aaaaaggcgg ctgaccgccg cccctcatcc ttatttaggg tagtcccttt 1870561 ttttcagctt gtttttttcc gccttgtact ttctgtaacc gacataggta agagcagtaa 1870621 tgatgatact gccggttgta atgatcaccc agagtaaaga cggatcggca tcatcctcct 1870681 ccaccctgtc aaacacattt ttcaggtcat gctgaagaag ggaaagccgt tcaagcttcg 1870741 tgctctctgt catttgctga aattcctctt gctcaataac atctatatgt tttccgactg 1870801 tttcaagctg atcctctgat acatcgattg taagactggg gtaaatcaag tcatataaac 1870861 tgataaattc attccatttt tcatgaaagc ttgtgcttcc attcttttgg acatctcgct 1870921 tcagttcagt aaaagcttcc ataatcggtt tttccagtga gccccaaagc gggtcagacc 1870981 gattgtcaac cgcatccatc agcattctga actgcgcggc tgctctgagt ttttgtgtgt 1871041 ctgatgtatc agcttgcttt aaactccgaa ccatatcatt atagcccaat gtgatttgac 1871101 gaatttgggc tcccgttagc atggggtctt gctgtttttt ctcagcggat tttaatgttt 1871161 tttcaaaata ctccaagact tgaagcgcct cttcatattt cgcctgtcgg gtcatttgaa 1871221 agactgtatc ggataaatca ttcaattcct cgaggcttcc ccgctctgca gccttggcat 1871281 ttccattata aaaaataagt gcaatcaaca aacagatcgt cagctttcgt ttcatgcagg 1871341 tccctcccac tctctctcct tacagaatat gaagaaaggg acaaggatag accaacattg 1871401 tctttacatc agctcaagct tcgtttgctt ttttgagacc acaagaaagt aagcaagcgc 1871461 gattgaaaag atacttagcc aaaatgttcc gtatcctatt tcagtcatat aatcagaaag 1871521 catagagtat tgcggcatca tatcaaacaa gtagtcaatg acatcgttat gcagtgtcca 1871581 gactgcagca attgcaagat gccaaaatga aaaacgaaaa tacggactgt ataatacgcc 1871641 ttgaactgcc attgcaaaat gcgaagcaat tagcatgtag ccctcccacg gcaagtcacc 1871701 agttactgca agcacaagaa aattcatagc caccgcccat aggccatact ttacgagggt 1871761 aactagcgca agcgcctcta aaagcggagc attccgtttc atgagaaagg caagcagcac 1871821 aaacagaaag aaaaacgttg ctgtcggact gtccggaaca aaaatcagga aacgggccgg 1871881 tgtctccaaa agctgcggca agtaccaata gtagccgtaa accgttccca gaaaattaat 1871941 ggctaagaca agaataagca tcggccgctg ccctaataca tattgaaacc atttcacatc 1872001 gaatcaactc tcagtctgta aaaataatat gtccatataa aaaagctgac gccgggtcag 1872061 cttttgataa taaaagtata tccttccatt tgacaattca caatacgtta ttttgcggtt 1872121 gtttcagaaa taaattttgc aagttcttcg agctgcttat catttccttt gaacacaccc 1872181 gccggcattt tgcctttccc ttctacagcg atttttttga tttcatccgg tttcagcccg 1872241 ctgtcaacca atgaaggccc ggccgctcct ccctgaaggt tatccccatg gcaagaaata 1872301 cagccctgtt ccttaaaaac cttatatcct tctgcattgg tgtcaatgtc ggcttctttt 1872361 gtaattttcc cctgttcttc tgccttggcc cagtcatgag tagcaactga ctgccacgtc 1872421 aaaaatacag cagcggaaat ggccagaagc atcataccga cagcgaccgg acgcttccac 1872481 ggccttcttt ctgtccctct gtctaggaat ggagccaaaa gcagggcccc aaaagcgaga 1872541 cctggcataa tcatggcgcc gaccactgta aagcttccgg cggcgtattc atacttcaac 1872601 agctggtata agaaaagaaa ataccaatcc ggcagcggaa tataaccagt atcagtcggg 1872661 tccgccatcc gctctaaagg cggctgatgc acaatcgtca aaacgagaaa accgatgaga 1872721 aagacagctc caaccatcca ttcctttaac aagaaatttg gccagaaagc ctctgtttta 1872781 cccggatact ccgaataatc cttcggtata ttcggctttt tttcagccgg tatccttgag 1872841 tcgcctacaa atttcatccc tttgccccgg tgcatgtcat cccctccctt ttattcgcag 1872901 atcaagagtt taaagcggtc ctgaaatccc ctgcttccgg atcataataa aatgtgcagc 1872961 catcagcccg aacaatgcgg caggaagaaa aaatacatgg atcgcaaaaa acctagtcag 1873021 cgtttgggcg cctacaatat ccggatgccc tgcaaggagc gttttaactt gcgttccgat 1873081 caaaggcgtg gcttcggcga tctgcagtcc gacttttgtt gcaaacagag ccttcatatc 1873141 ccaaggaagc aagtagcctg taaagccaag accgagcata acaaaaaaga tcagcacacc 1873201 gacaatccag ttcagctcgc gcggtttttt atacgcgcct tggaaaaaga ccctcagcgt 1873261 atgtaaaaac atcatcacaa tgaccaggct cgcaccccag tggtgcatcc ccctgacaat 1873321 ctggccgaat gccacttcat tttgcaaata atataccgat tcccaggcat ttttgatatc 1873381 aggcacataa tacatcgtta aaaacattcc agataatact tggataacgg ttacaaaaaa 1873441 cgtcagtccc ccaaagcaat acacaaacgc agagaaatga tgggcgggat tcacatgttc 1873501 cggtacttcg tgatcggcaa tatccctcca catcggtgta atatcaagcc gctcgtctac 1873561 ccagtcataa attttgttca gcatgtcacc cttccccctt aggctttgct tttccaagat 1873621 acaggaagcc gtcttttact tcttgctcat aatgatcaag aggcgcaagc ggcggcgtgc 1873681 cagggacatt ggtgccgtcc ttttcataga gtccgtaatg gcatggacaa aagaatttat 1873741 tcgggttttt aggatcacta ttccagttca ccgtacaccc taaatgctta caaattggcg 1873801 aaagtgctac aatttcatcc ccgtttttga agacccaggc tgatcttgac tcttctgact 1873861 cataccaggc atcgacttga ttaattttaa aatcaaagcg ctgcggctct tttgtcaact 1873921 catcaacgct gacaacctga accatatcct gcttccctgt cgattttaat accgggtcga 1873981 gtgcgaagcg aaccataggc atgagcatac tagccgccat aaaacctcct acgcctgtga 1874041 gcgtataatt caaaaattga cgtctggata tatcatgttt tccgcccatc tcttctcccc 1874101 cctctaagtc acccctgcaa actgactaaa atagaaaata ttgcaataac tctagacacc 1874161 ctcataatat atgaatctct cagcaaggtc aatatagcca aaatattgtt tataaggaaa 1874221 tgtaagtgtt tttataaagt gctccataac tgtaacaaaa cgttcaaaat ttcagcagtg 1874281 cgttcatcca atatttttct ttttaaagag tcatttaaat gctctaatgg aacagacgat 1874341 gtaacaatca ttttgcctaa cgcatcctca gctctccaac tttcgtcaga tgtgagcagg 1874401 acaacatgcg gaaattccgt tatcagctct tcccgcaaat ccttaagccc ttgaacggtt 1874461 atttcatttc tatcaacata tgtataaggc ggaagtaaat atacccgtcc ctttaactgc 1874521 ctttcaagtt cttctgagag aagctgcgta aactcgcctt tctccgccgc cattttaaaa 1874581 tggttattaa cccttatgtt aattaatggt atgacagcgg tatcaatgta atccttagct 1874641 tgtaaatagt ccttggcatc agtgattctc cacctcatcg ttctccccct ttacggcaac 1874701 aagccttgca attcactgca aggctggtca tattatgtga gctgatttaa ttggcgcgat 1874761 aattgttcaa atgcctcttt atcatgacga tctaacgcgt cgtcaatgtc ttttaataat 1874821 ttttctcttt ggaatgtgga aatagcgtgc tctaaaatct gttccgccaa tccctgatct 1874881 tttttattct caaaaaggtt tttcggaata tgcgggttgg actccagcac cgccgcatat 1874941 tcaggtgagc tgtaagccga acggaaatta agctggataa acaaatcctg ctgtttattt 1875001 aatctaatat catgaaaaga tttttccgcg tcggtagtca tgacattctc tttatagaac 1875061 cggaacggaa cttcttcaac acaatgtgtt gacattataa tgcctctcgg gcaaaattca 1875121 gcctgctcca caaaatgaac cttctccatg agagaatcat ggctcattaa gtagttcaag 1875181 atccaaacgc actctcggcg ctttaactga taatggttta aaaaccaacg gataaaatct 1875241 tttttctcat tgacagaaac aggggtctgc atgtaattcc ctcctctatc gttcgtataa 1875301 tctatatact tatatgttcc acatgaatgg ttaatattcc tgcttatcta gaaaattcat 1875361 cctcgattcg caaaatcgtt tcttcaagct cttcattggc tccgtccatt tcaagaacct 1875421 ttttcaaaag cggcagcgct tctttttgaa gaccttcttc taataggaag cttgcgtatt 1875481 catataagaa atctctatcc tcccggtaat gaagataggc agcctcaaag gattgttttg 1875541 cttcctcgta ttgctctaat tcagtatatg cgcttgcaag ataccaattg tatttaggat 1875601 cttcttcacc gtagcttcga acctcttgaa taagatcaat gatctgatca taatcctctt 1875661 ctttgtgata cacggcaaga agtgtatgaa gcgcctcgac aaagcccgga tcaagcgcaa 1875721 gcgcctcctg aagcagcttc ttcccctctt ctgacttccc gattttcaag gccattttgg 1875781 cggcataaag gaaaagttct ttgttatatt catcatatct gatcccctct tttgccgttt 1875841 ttaatgcctc ttcatacatt ccttcagctt catagctttt cgagagcggc atataaagtg 1875901 aagtataaga tggatcaagc tcctttaaat cagacagctg cttaatagct gttttcacaa 1875961 gccccgcctg taaggctgta aaaccatagc cgaaaatcgt attaggatca ggattctcat 1876021 cgacagcttt ctcataccat ggaatggcat cctcaaattc acctgaggca cttaacgatt 1876081 ctgccagtct ttgatggaca ttaacgcccc cgatctcact ctgctcctca gccgttgttt 1876141 taaaatattg aaccgctttt gcataggctc cctgagcaaa gtaaagttct cccagtgcaa 1876201 aatcaataac aggttcattg tccagaatgg actttgcctg gaaaagcttt tgttcactga 1876261 cttcgaataa cccctgcatc tgataaagat ccgccataag cagcaaactt tccggatatg 1876321 atggatctgt ttccggaata gtctccagca cagcgagggc tttttcttct tcgtcaatat 1876381 ctattaaaag ttcagcgtag aaattcgtca gttctgtttc atttggatat aaatcatgta 1876441 gatcactaat cagtgaaatg gctttttcta catcgcccca ctcgtaataa agctgggctg 1876501 caatggcttt atcttcatca tgcagctgtt tttcagcctt cgagagcgtg ttgaggcctt 1876561 tttctgtttc acctgcttca actaatttta tggcttcttg aatcaatgta ttcaaatcgg 1876621 accggtcctt tcttttccta tacaacatca accatacaaa aaaagcttta tttgttcggg 1876681 ttaatcttat cataattcag acgaatgccc ccggcaaata agatgcttct gtacggaagg 1876741 gaattattga gtcttattag tttaccaaaa gatcttgaga tagaaaatga aaaaaggaag 1876801 atcgccctct gtacagtaaa gcagctcttt gacctgccgg cttgtaagta aagcacatcc 1876861 ccccttttcg tttttctatc cgttctataa gacaagctat gttttttcgc ctcgaattat 1876921 gatctgcata aaaaatcctg aagtaaaact tcaggatttt ttcgaaagct tatttaaatg 1876981 ctcgaagaag gttggataag aaacgtgaat ggcatccgtg tgctcgattt caatcggctc 1877041 ctccgttata caggaagcaa taccaagcat cattccgatt cgatgatctc cgtggctgga 1877101 cactgcagcg ccgcctttca acgtttgttt gccataaacc ttcattccat ctgctgtcgg 1877161 ttcaatttca gcacccagct tgcgaagctc agaaacaaca gtatcaatac ggtttgtttc 1877221 tttcactttt agctctgccg cgtccttaat aacggtggtt ccttccgcct gagtcgcaag 1877281 aagcgcgatg atagggatct catcaattaa acgcggaatg atatctcctc cgatttcaac 1877341 tgcctttaga gatgacgttt ctataatcaa atctccataa ggctctgcac cgctatcagc 1877401 agatggtttg atttcaagtt ttgcccccat gttttgaagg acatcaataa tacctgtccg 1877461 agtcggattt aaacctacgt ttttcaatac aattctgctg tttggaacca tcgcgccagc 1877521 agcaaggaaa aacgcggctg aagaaatgtc tccaggaaca aaaatatcag cagctgtcag 1877581 tttctggcca ccagcaatgg aaacactcgt ttgatcttca gaaagcttaa cgccaaaagc 1877641 agaaagcatc cgctcagtgt ggtcccgaga tttatggggc tctgttacag ttgttgtgcc 1877701 ctcagcctgt aatccggcca gcaaaacagc agatttaatt tgcgcgcttg caacaggtga 1877761 tacataatca attcctttta atgaagcgcc gctcactgac agcggtgtaa actctccgcc 1877821 ggctctgccg tcgattttag cccccatttt tttcaaaggc tcagtcacac gcttcattgg 1877881 gcgtttcgca atgctctcat ctccggctac cgcgctgtaa aaaggacggc ccgccaatat 1877941 tccgagcatc aggcgaatcg ttgtacctga atttccgaca tctaaaaggc tttctggctc 1878001 tttcagggca tcgattcctt ttccgtgaat cacgacatcg ctgctgcttt gctcaatgtg 1878061 aacacccatt tttctaaagc aatcgatcgt gctcagacaa tctgctcccg gcagaaagtt 1878121 tttaactgtt gttgtgcctg ccgctagcgc gccaaacata acagagcggt gagaaatgga 1878181 tttatcaccg ggaatatgta tttctccatg taaggtctgc accttatctc gtttcatttt 1878241 ttccacctca atcagcataa aaagtttcat attccgcccg ggcttcaatg cattgttctg 1878301 cccttttgcg gtcgtcatca gactgaaaac tgatccttaa aatcccgtta atatcctctc 1878361 gtgtttcgat aatgcggata ttcgtgatac tgatgcgctc cgcagctaag atcgctgtta 1878421 tctcggatat tacacccgga tgatcgggta catccacata taaatcataa aatgcaggta 1878481 tcgctccctt ctgccgaagc ggcagcccgt cgcgataatc cttggctgtt ttaaaataac 1878541 gaaatagatt ttccgcatct tcttgttcta catatgtacg gatcttgtca atttcacgaa 1878601 tccactcatc aaaacggtct aagattttat ctttattatg taataaaata tcccgccaca 1878661 ttgccgggct gcttgatgca atccttgtaa tatctctgaa cccgccggca gcaaaacgct 1878721 taacaagcgg atacaggttt tccgaatgat gggtttggtg aacaaggcta gctgctacaa 1878781 tatgcggaaa atgactgatt acgcttgtaa cgccatcatg ctcctctggc gacatttcca 1878841 caaaatgggc attcgtcccc ttcagcaggt tttttaactg ttccacagct tgtttgtccg 1878901 ttttctggcc tggcgttaaa atataaaatg cattttcaaa caggaactcc ttcgcagcgg 1878961 ccactcctga tttatgtgaa cccgccatcg gatgccctcc gacaaattga tagcggctag 1879021 gcagcacttg atcagcgtaa tcaaccactt tttgctttgt gcttcctaca tccgtaatca 1879081 aaagctcatg ttcaattcct gaatgagcca gctcttcaag cataaccagt gtttgttcaa 1879141 caggtgtcgc aatgattact gtagctgcct ctttcacacc gctaataaac gaatcagcac 1879201 gatcgtctat cacgcctaat tttaatgccg ctaccgcctg ttcatcagag atgtcgattc 1879261 cgataatccg tttgccggga tgattttttt tgatggctag ggcaatcgaa ccgcctatca 1879321 atccgagacc ggcgagcaat attgtatctt tcatttgatt catacgtcat cacctggttt 1879381 atagactaaa gaggtgatat ttgatcacct cttataaaat ttcagctaaa atggcaagta 1879441 tttcttcatt ttgctctttt gttccgatcg taatccggag tgatgtcggg aaacctaatg 1879501 cgtttcctga ccggacgata tagccttttt ccagcagagc ctgaaacagt tcatcagcag 1879561 gacgtttaaa gtcaattaac acaaaatttg tctgtgaagg gtagcacttt aaaccatgag 1879621 ttttcgcaaa atcataatac tgctgaaggc ctgcattatt ttgctcgaca caggaagcaa 1879681 taaacgcttg atcatcaagt gctgcaatcg ccgcagcctg gcccagacgg ctggtattaa 1879741 acggctctct cgccggctca atctggcgaa tcaggttctc gtcagcaatt ccgtatccga 1879801 ctctgagcgc tgccagaccg tatgcctttg aaaatgtgcg caaaatcatc aaattggaat 1879861 acttgcttaa gagcggcacg gtttccgggt aatcctctgc tgttacatat tcataatatg 1879921 cttcgtcaag aacgacaagg acacgagaag gaacgcgctc cagaaatgcg agtaattctc 1879981 cttcagatgt ataagtgcca gtcggattat tcgggctgca tatccaaacg acttgtgtct 1880041 gttcgtcgat ggcttctaac atggcgtcta aatcatgtga gccgtcggga cgaagtgcaa 1880101 tttcacgtac ttcagcacct tcaataaccg cattatgttt atattgcgga aaagtggggg 1880161 cagcagtaac cgtgtttgtt ttatcgttta aaaatgcccg gcagatgatc tgtatgattt 1880221 catcagaacc gttgccgaaa ataagtgatg tttcgctgac attgaggtgc ttactgagcc 1880281 ttgtccgcaa agcggcgcta tacccgtccg ggtaaagggc tagctgttga atctcatgat 1880341 gaagcgcctc ttttgcagcc tctgaacagc cgtaaggatt ctcgtttgaa gcaagcttca 1880401 caactttatc caagccatat tctgatttca ctgcttcaat cggctttcca ggctgataag 1880461 gcttcagctg ttttaaatgt tctttgatac gcaaatcagt cacctcattt taaactgtac 1880521 aagccgctaa acgccattgc ataatcctca aactcctgca gcgcctgatt tctcgtttca 1880581 gcgctgatga gccggtcctt taattcttct atttttctga cgagcgcact tcccactacg 1880641 acaccgtcac taatttcatt catctttatg acctgttcac ggtttgatat accgaaccct 1880701 acagcaaccg gaacagtgct gagattcttc acagtacgaa tgaacgggta cacggatgaa 1880761 ttgaactcat tgcggacacc ggtcacaccc agagaagata cacagtagac gaacccctcg 1880821 gcttgttcaa taatggtttt caaacggctt tcgcttgtcg gcgcaactaa agaaatatac 1880881 gtcacctcat ggcttttaca ttcctcttga aggctgttgc tttcttctaa tggcagatcc 1880941 ggaacaagca gaccgtcaat atgattttcc cgcagtaaag cgaaaaagta ttctttgttc 1881001 aattgtaaca caggattata atacgtaaag aggataatcg gaatattcac tccgtttttt 1881061 ttcatttctc cgcctaattc gattgccttt acgatattca ttccttgatc aagcgcccgc 1881121 tttgaagccc gctggatcac cggaccgtct gcaagcgggt cagagtatgc aacaccaagc 1881181 tccaatgctg tggcgcctgc tttttggagt gacttcgcca gttcaatcga aacctcagga 1881241 actggatcgc ccgccgtaat aaacgggata aacaattttt ctgatggttg aagatccaat 1881301 ttaaacatgg gctttcacct cttcttccaa tacattcatt aatgtgttga catccttgtc 1881361 tccccggcct gataaacaga cgagaatgag ttgaccgcga tccattcctt tggcgagttt 1881421 gaatgctttc gctaacgcat gggcagattc gattgccggc aaaatcccct ctttttctga 1881481 caaaagcttt aatgcatcca ccgcttcttc atcggttata ctgtcataag tgacacggcc 1881541 gcttttatgc aaatatgcat gctccggacc gattccagga tagtcgagac cggctgaaat 1881601 agagtagggc tcaataattt gcccgaactc atcctgaatg agataagtca atgaaccgtg 1881661 aataacccct acggttcctt tcgaaatagt ggcggcatga agaggtgtat caattccttt 1881721 tcctgctgct tcagcgccga tcagttcaac atcttcattt aaaaatgcct gaaacatacc 1881781 catcgcattg cttcctccgc ctacacatgc cactacttta tcaggcatag tgccttcaat 1881841 acgtttcaac tgatccttcg cttcctctcc gatcattttt tgaaattcac ggaccacttg 1881901 cggataagga tgcgggccga caactgatcc aatcatataa aagtgatcct cacaatgctg 1881961 aacccagtac cggatcgcct catttgtggc atccttcaat gttccgtttc cgcttgttac 1882021 aggcactacc tccgctccaa gaagcttcat gcggaaaacg ttcagagact ggcgggcaac 1882081 atcctcttca cccataaaca cagtacagga aaagccgaat ttggctgcaa ctgttgcagc 1882141 ggcaacacca tgctggccgg caccggtttc agcaatgatt ttcgttttgc ccattttttt 1882201 agcaagcagc gcttgaccta gcgcattatt gattttatga gaacctgtat ggtttaaatc 1882261 ttctcgtttc aaatagattt tcgcgccgcc taagtattca gtgactcgat cagcgtatgt 1882321 taatgcagtc gggcgtccgg aatagtcctt taacagctta taatactctt cacgaaaagc 1882381 gggatcatcc ttgatttgtt taaatgctgt ttgtatttca tctaacggct gcatgagtgt 1882441 ttccggaaca aactttccgc caaaatcacc gtatctgcct atttcattcg gatatggata 1882501 catatcggtt catcctttct tctaaaagcc tcatcagatt ctgatctttt tgtccgtttt 1882561 tttcaattcc gctggcaagg tcaattcctt ctggctgcca tttcaatagg cgtgtgatgc 1882621 tatccggatt cacgccgcca gcgataaagc agcgtttacc aatagccgcc tgctgatatt 1882681 ccggcacaca ttcccaagaa aatgcaacac cagttccgcc tctagaccct tttacagatg 1882741 aatcaatcac aaagccgtca acattatctt taaagcgggc tatttcttga gttgtgttat 1882801 cttgatggtg aagcgccttc catatttcac agcctgtcag cttgcgaaga gcagcagcat 1882861 ccgccggttt ttcatcaccg tgaagctgaa tgacgtcgag cttcaagctc ttggcaatac 1882921 gtgacatcgt ctctattgat tcattaacaa aaacacctgc aacctgtttt tcgacacgaa 1882981 cttggttcag ccattttttc acatcttccg gagatacttt tcgtttgctt tcagcaaaaa 1883041 taaatcctag gtaatcagcc tgtgattccg ccgcaagctg caaatccttt agtgaccgaa 1883101 taccgcaata ttttaatgcc ggtttcttca caacctcact ccctaaacaa agcatggatt 1883161 gctttacgct gagaagtttg tctcatcaat gattcaccga taagtacagc tcgtgctcca 1883221 tgttctttga caaatgttaa atgttctaaa gaaccgattc cgctttcgct gacaagcagt 1883281 gattctttcg gagcaagaga tgcgatttgt tctgtctgca tgatagaggt ttcaaaagtt 1883341 tttaggtttc ggttgtttat gccgagaata tcaggcgtga atactttcaa tatttgttct 1883401 agcgttgttg catcatgaac ctccactaac acgtccatct ccttttcacc tgcttcaaga 1883461 tataattcat gaaggtgtaa gggatcaagc acttcgccga ttaacaatat ggcatccgct 1883521 ccgattcttc ttgattcctc cacttgaaga gaatcaataa taaaatcttt tctgagtaca 1883581 ggtatcgaaa cagcgcgctt tacgtctgat aaatagctgt tttccccttg aaaaaacggg 1883641 gtgtctgtta aaacggaaag cgcatctgct ttcgcagttt catagtcttt tgcaatccgc 1883701 acaggtacaa aattctcttt aataagccct tttgacggcg acgctttctt cacttcagca 1883761 atcaacccga taaaccgatt caggcttgcc agcgcctctt taaatgaacg tttttcgaaa 1883821 ggctgctcta ccggcagaac cagtgttttc acttcttctt tcttttgttt gatgattttt 1883881 tcaagcatag atctcttcct ctttctgctt tagtcgttca agctgcgcgg cagcgcctcc 1883941 gcttgtaatc gtctctaacg ccagctccgt tccttccttc agtgaggcgg taattcccgc 1884001 cgtgtaaatc gcagcacccg cattaaaagc cgtaatagat aaagcggaac tgctgctttt 1884061 attttcaaaa atattctgaa tgagataagc gctctctttc ggagactgca cctgtaaatc 1884121 ttcaagtctg ccatttgtga aaccgaaatc ttcgggtgaa acggtatact cccggcgctc 1884181 tccgtccttt aattcaatca cgtcggtcgg tgctgtaatt gaaagctcat ctaaaccgtc 1884241 acggcttgat acaaacataa cgtgcttcgg ctgaaacgtc tccagtgcgc ttgccatcag 1884301 tccagctttt tcaacagaat agaccccaat cacctgacgc ttcgcctgta aaggattgct 1884361 gagcggccca agcagattaa ataccgttct gaaacctagc tcttttctag tacctgctac 1884421 atgtttcata gacgaatggt aaagcggcgc aaaaagaaat cccatgttgt ttgtttcaat 1884481 gctgcttttg accttttcgg gagtggtttg aatagaaacc tctagctcct ctaaaacatc 1884541 agcgcttccg cttttagaag agacagagcg attgccatgc ttagcgattt tcgcaccagc 1884601 tgccgaggca acaattgccg aggccgttga gatattaaaa gtggaaatac cgtctccccc 1884661 tgttccgcat gtatcaacaa tatcaggaag tccatcgact gtaagagcgt gtgcccgcat 1884721 tgccttcaca aaacccgcaa gctcttctgg cgtctccccc cgatgagcaa gaattgacaa 1884781 tatccccccc atttcagaag gagtcatttc cgctgccatc atcatattca tcagcgtttc 1884841 agcctcaccg gcagtaaggg tttttccgtc aacgcacaat tgtagaaatc tgttcatcag 1884901 ctttatcctc cttgctatga aacatgtctt ctgcaatatg aatcgttttc agcagcgcac 1884961 cggctttatt acagctttct tcgtattcgg cttccggaac agaatcagca acaatgccag 1885021 cacctgcctg tatcgatgca acaccgttct ttacactcat cgtgcgaatc gtaatacaag 1885081 agtcgatatt cccgtcaaac ccaatgtagg caatacaccc tccgtatgtc tctctcggtg 1885141 ttggctcgag ttcttgcaaa agctgcatgg cacggatttt gggtgcgcct gttaaagtcc 1885201 ccgccgggaa agcagacatc agtgcatcga caggatgaac cccttttttc aatcggcctg 1885261 taaccaccga gataatgtgc atgacatgtg aaaaggaaac aatttttgtg aactccggca 1885321 cagaaacaga accatactct gctactctgc cgatatcgtt tcgggcaaga tcaacgagca 1885381 tgtaatgctc cgctttttct ttttcatcct tcatgagctc aaccttcagt ctctcatctt 1885441 cagctttgtc tgcaccgcgt tttctcgtac cggcaatcgg atggatttct aagtgcccgt 1885501 cttgaacgtg tattaaccgt tccggagagc tgccgactat ttctctgtct agcagtttca 1885561 tataatacat atacggcgaa ggattgacga tcctaagcac tcggtataac tcaaaagcat 1885621 ctgcttttat cggcacctca aatttttgtg ataaaacacc ctggaagata tcgcctgctt 1885681 ttatatagct tttgattttt tctacatcag ccataaaagc cgatttttca taattagaag 1885741 atactgtctc aaagctgggt gtcttgtatg aatcagcaga aagaaacagc tcttttatgt 1885801 ttttttggtc catcattttt tcaatgagat tttgaagctc cagatgattt tgatggaata 1885861 catccatttt ttcgtttttt gtttcctctc cagtgagcct tgcatattgg ataaagtgga 1885921 cgtttttggt ttcatgatca tacgcaatta atgtccggca aacaaacagc atacactttt 1885981 ccatgtctgt ttctttggta tgcgaaggaa cagaaggctc aatcagcggg atcatatcat 1886041 agcttaagta cccgacagct ccgccgacaa aaggaatgcc aagctcaggt gttttgattt 1886101 tgtatgtggt attcatccag ttcagcactt cttttagttc atttcctgtg taaagagatt 1886161 tgctgtcctg atcagcggcc gaaaaacggc cctgctcttc tttaattgtg agaaatggat 1886221 tcaggccgat aaacgaatat ctggaccaag tggatgtatc gtccttgctt tcaagaagat 1886281 acgtaatctc cctgtcaagc ttctctatca tttgaatggg tgtcagtgta tcgactgtga 1886341 aggtctccac aatcggtatc gtgtggtggg acaagctgtc ctctaaaaat gcggaaatgt 1886401 ttgattggaa attcattgct ctcactcctt atggcaagga gaatgagaag atggcatgag 1886461 aggataaaat actatataac aaataaaccc aaaagaaaga cttcttttgg gtagaataaa 1886521 cataatgtct cagctcaact aaactcattc tctgctaccc tattctctaa ctcaactcat 1886581 tctaattgct ttatacacac tcttgtgtat ttctaagctg ttcttatcgt attacaattc 1886641 agtatttttt gtcaatgata aatcgggcct caatacgaca actttttcta aatatacatg 1886701 tctgatctga tcctgaggga catctgtctg gaccgtcatc atgactctta tgcacttttt 1886761 cagaccgcct gttacgtcca tttcctgcat acatgttacc ggtacatact gccatcctga 1886821 aagctcgcga acagcttttg ccgggaaaac agcgtgcaaa tcaggtgtag ccgacagaag 1886881 catttgaaca acatcttccg gttttgtatg attttcttct atgattttct ctaacagctg 1886941 tttagttttt tgtaaaattt cttcttcagt atcccgttca actgtagttg ctccgcgaat 1887001 tccgcgaatc atcatgatgt ctcctccaat cgccatttgt tcagccagct ctcaagttca 1887061 tttctggaaa atgtatgatc agcaactttc cctaattcgt tgagcacaat aaactgaatc 1887121 ttcccgccac gggttttctt atcattcatc atacggttca agagaaccga agtttccgtc 1887181 tcttttctga tttgacttgg ataacccagg ctttttagcc agctgaccaa acgttttctg 1887241 tccatttcac agcctacagt cttttcgctt atatataaag caaactgcat tccgagggct 1887301 acggcatcac cgtgagtgat ctgcccatat ccatattccg cctcaacggc atggccgagc 1887361 gtatgcccaa agtttaagta agctcttatc ccctcttctt tttcatcctg ctgaacgaca 1887421 gacgctttaa ttgaaatgcc tttaaaaatc atgtcattca gctgatcatt agtgatatca 1887481 cgcagtgagt ggatattcag cagctcctcc agaaacgctc tgtcatagat aaaagcgtgt 1887541 ttaatcactt ctgccattcc ggacctaagc tctttttcag gcagagaacg caggaaatct 1887601 gtatcataga gcacggcttt cggctgataa aacgcaccga ttagattttt tccaagcgga 1887661 tggttcacgg ctacttttcc tccgactgcg ctgtcatgcg ccaagagcgt cgtaggcatt 1887721 tggatgaaat caatgccgcg cataaaagtg gcagccacaa aaccggcaag atcccctaca 1887781 acaccgccac cgaatgcgat gatgcatgag gagcgatcca tatgaaaacg aatcgcttca 1887841 ctctgcaatt ttgtgtacat gtccatggat tttgcctgct ctccactcgg taccgtcact 1887901 tttttcacag gccatttttc ttgcagcaaa tggagcattt catcaccata caggcggtcc 1887961 acttcttcat ccgtgacaaa cataatcctt gttaaaggcc tgtttaaaga ggttaatagt 1888021 tcgcaagcct tttttctgat accttgtccg ataaaaacag gatatgacga ggaagcagtt 1888081 tgaacatgca gtgtcttcat taaaattccc tcgacagttt tctcatattc tccacatttt 1888141 ctctaatgcg gtcaatttga tctaatccga attgttcaac gactgcgttc gcaatttccc 1888201 aagcgacagc cgcttcagcg actacacttg ccgcaggaac agcacagctg tctgaacgtt 1888261 caatgctggc agaaaacggt tctttcgttt caatatcgac acttttcagc ggtttataca 1888321 aagtcggaat cggcttcatg actccgcgga caacaatcgg catccctgtc gtcatgccgc 1888381 cttccagtcc gccaagtctg ttagtagcac gggtgtatcc tttttcctcg tcccaaatga 1888441 tctcgtcatg gacttcgctt ccatttcgcc ctgctgcctc aaatccgatg ccgaattcca 1888501 cacctttaaa tgcgttaatt gacagaacag cggcagcaag cttgctatcc agcttgcggt 1888561 cataatggac atagctgccc acgcctaccg gcattccctc gacaatgact tctactattc 1888621 cgccgatgga atctccgttt gcctttgctt catcaatggc agccatcatt tttttgcctg 1888681 cctcttcatc gtagcatctg acaggagact cttccgttac acgctgcaag tcttcaattg 1888741 acgtatactc tgttttttca gctttaacag cgccaatttg caacacgtgg cccgccacct 1888801 taatgccaag ctcagaaaga atctttttag ctacagcccc tgccgccact ctgacagttg 1888861 tttcccttgc tgaagaacgc tcaagcacat ttctcatatc acgatgatta tatttaattg 1888921 caccgtttaa gtcagcgtgc ccaggtctcg gtctggaaat ctggcgcttc atttcctttt 1888981 cttcatcttc tgtaatcgga gcggcgccca tgatttttgt ccaatgcttc caatcgttat 1889041 tttcaactac gagagcaatt ggcgaaccga gtgtacgtgc atggcgcacc ccgctcataa 1889101 ttttggcctg gtctttttcg atctgcatgc ggcggccgcg gccgtgtcct ttttggcgtc 1889161 tggcaagctc aaaattgata tcttcctccg ttatgtaaag cccggcaggt acaccctcaa 1889221 taatggttgt cagttggggg ccgtgtgatt ctccggctgt taaatatctc atgacttctt 1889281 ctcccttcat cgcattaacg cttttaagta agactactat aacatatttt tcagcaaaaa 1889341 gtcagtctat cttttttgat aaaagaatgt atcggctggg actaggccaa atttctcggg 1889401 attgaagatt tgctcggtgc tgccgacaaa aagaactcca ttcttcttca agctatgtgc 1889461 catttttaaa tacagctctt ccttcgcgct ttctgtaaaa taaataaata cattgcggca 1889521 cacgattaag tcaaagtctt gttcataacg atccgccagc aaattgtgct ttttgaatgt 1889581 aatattcttt ttgatttccg ttttcacttc ataacttcta tttgcgtttt gcgtaaaata 1889641 acgatctttc acagatagcg gcacttcctg taaagaccgc tcctgataaa cgcctttttt 1889701 cgctttttcc aatgcttttt catcaatatc cgtcgctaaa atctgatagc ccggaagacc 1889761 tttttgctgg tccaaaagca tggcaagcgt gtatggctcc tcccccgttg agcaggcggc 1889821 actccaaatt tttaaaggcc tagaggtctt gattaacggc agaattgcag tctcaagaac 1889881 ttcccatctt ttataattac gataaaattc tgaaacattg atcgtcattc tgtccaatgt 1889941 ttcatttaag agagcttgat ccttttccaa tgccgcagca aagtccttaa agctttggaa 1890001 cccctttttc tcataaagtg acgttagcct tctcttcatt tgtgcttctt tatatagtgt 1890061 taaatcgact ccggttaatt gtttccattt cgttgtaaat acgctgtatg tatccatctc 1890121 tactctccca gtctcgctgt ctttttgtcc tagtatagct tgttttatca ggaaattgta 1890181 ttgtttcaat aaaaaaatca gcttttcagc tgattttaga tcgttgggaa aggcagaggt 1890241 ctgatgcaca ctgccattca accctttatt cactttaatg taaaccttta caaaacagaa 1890301 caaaaaccgg cggcgttata tgttgccggc tctgttgctt attttcacaa tgattaatag 1890361 atccagcctg ccataagctg ctgatatgat actaattctt cattcttaaa gaaaatgtta 1890421 atctcgcgtt ctgcactttc gagagaatca gagccgtgga tgatgttttt tccgacaaac 1890481 atgccataat ccccacgaat cgtaccaggt aaagcttctt tagggtttgt tttcccgatc 1890541 agctgtctcg tcacttcaat gacattttcg ccttcccaca ccattgcgaa tacaggtcct 1890601 gaagtaataa actcaacgag ctctccgaag aaaggcttac cttgatgttc ggcgtagtgt 1890661 ttctcagcca tttgttcagt cactctcatt aacttggcgc cagctaattg taagccctta 1890721 cgttcgaatc tagataaaat gtccccaatg agctgacgtt ggacaccgtc tggtttcacc 1890781 atgataaaag tcttttccat catattctcc accccatcat tatgtatgta taggctttca 1890841 cactgcacac cgaaatcgta acatctttct gataattaat caatccgggg cggagaaatt 1890901 tcttaatatc tacaaaaatt aaaattttct tttaccgata tattttgcga tggctgcaag 1890961 agacgagcgt gcgcgccctc gaggaagcgt gtttaatttc tgaaaagctt tctgcagata 1891021 catttcgctt actgccatag atgcttcaat tgcatctgtt tttttgattt cttcaatgat 1891081 tggttcaagc tgttcctgcg ttgtctcact gttaatcaat ttaagctggt tttttaatgc 1891141 aggatttttc agggcataca gcactggcaa tgtgacgttt ccttgaagca aatctcctcc 1891201 tacgggttta cccagctctt cctcagttga agtaaaatca agaatatcat caataatctg 1891261 ataagacatg ccgacgtaat acccaaacca gtacaatgcc ttatgaatct tctcatcagc 1891321 tccagacgca atggcaccaa gctggcagct gaccgcgatc aagagagctg tttttctttt 1891381 gatacggcgg agatacgttc tgagattttg ttccatgttg tatttgtctt tgatctgctc 1891441 aatttcccct agacaaactt caacgatcgt ctgtgacaaa atcctatggg ctttcggttc 1891501 gttaattctc gtcatcattt caagagatcc cgcaagcata taatcgcctg tgtacatcgc 1891561 aatacgattg tcccactttg ctttgattgt cggttttcct cggcgaagct ctgcatcatc 1891621 aatgacatca tcatgaacca aagatgccat gtgaatcatt tccagagtga cggcgacata 1891681 tttaatctta ttaatatcat aatcgccaaa catgccagaa agcagcacga aaacaggccg 1891741 aatacgtttc cctccggcct gcagcaggtg aagacctgcc tcgcttaaaa gcgggtaatc 1891801 ggaacgtacg gtttgttcaa gttctctttc gattacatca atatcgtcat ttaaaaaaga 1891861 gtaggccatt ttaaatttca tatcattcac ccaaacatct gtgttttcat ttccatccga 1891921 tatgcgtggc agcgactccg ccagtaaacg aatgatattt aacatttttc aggcccgcct 1891981 cttcaaacag gcctgccagt tccttcattc cagggaaatc tctggctgat tcttgaagcc 1892041 aagaatattc tttatagctc ttcgcaaaca gtttcccgaa aaacggcata atatacttaa 1892101 agtacataaa gtaagcctgt ctgaatccga acatttccgg ctgggacgtt tccagacata 1892161 ccacctgccc gcccggcttc actacacgtc tcatctcttt cagtacagtc aagtaatcag 1892221 ggacattgcg gagtccgaag ccaatggtga cataatcaaa tgtatcatca tcaaaaggaa 1892281 gctccatcgc atttccgtgc agcagttcaa tttggctgaa tccgccgtct tttactttct 1892341 gctcgccgac actcagcata ttttcactga aatccaagcc cttgatctcg ccgcttttgc 1892401 ctgccgcttt tgcaagagcg atcgtccagt cagccgttcc gcagcagaca tcaagtgctt 1892461 ttgcgccttc ctttacattc atgatgcgca tcgttttgtc gcgccatttt ttatgctgct 1892521 gaaaactgat gacagagttc atttggtcat aatttttata tattttttca aatactccgt 1892581 gtacgcgctg ttcttttgag tcctgcataa tggtttaccc ttcttccact ttctgatgat 1892641 aggtttgatc ttggctgatt gtcttcagac ggtttattaa aatgttctga ataggtgaat 1892701 ttagaggcag aagtgactca atgctgtttt tcgctttttt aaaacaatct tctaatatct 1892761 cttcttttgt ttttcccagc tgtataaaac tgccgatcac atccagaaat gcatcatttc 1892821 cgttcataag ccgcttaaat acaaaaaaat cactcgacag ctttttccag cgcgggaggt 1892881 tgaagtgttc cgccacacga tggaataaag ctgattcaac gatgccgaca ctttcgaaaa 1892941 aatcgttttc gtccttgaaa gaacggtcat acagacgaat tttatgttcg ttgatttctt 1893001 taatggctgt agcaagcgtc cgaatcatgt agatatcctt catttcagat agtaaagagt 1893061 agtacagccc gctgaaataa tcgcccgcga gaacagtcaa ttggcggttt ttgttttcgt 1893121 ctcgttttat gactctagct gtcgtcactt catcatgggt atcaagggcg ctttgtacaa 1893181 gcatcgctgt tacaatataa ttttctctgt cgttgttttt tatgtcggct tcttcaaata 1893241 aagcatgaaa aagaagaagc ttatcctcat caattttcgg cgcagaaata tgcttcgcta 1893301 aataaggatg agacagcttt tgttttaatt tcgtgttcag attggctaaa gttccgtaga 1893361 tgtcttgcaa aaatatcacc cttgtcccca aattcacatt tatttcttaa tctatgtatg 1893421 agttttatct tttcattcgc ttacgcaggt atcattatag cataaaaaaa agaaattggc 1893481 tgtatcctcc cgctgtttgc gagcatttgc ttttaacagc ggggacagcc agcttatttt 1893541 ttttcgcttt tcatttctcc gtacgcggtt tgaatcagtg cctctcctct gactttaatg 1893601 gcagaagtat gctctgtaaa ctgagcgatg atcacttctc ccttgtcgag tttttcggaa 1893661 tggtgaaact ttgtgtctgt tcctcttgtc aggccgatca cattcactcc gtcctcaacg 1893721 gctttaatga cgacaaaatc acttgaatgc ttttggttca tttatagcac cctctatctt 1893781 tattagtcct ggcgtttaat atgttccaat acttctgcac gggcagcggc atcatcttta 1893841 aaaacgcctc tgactgctga agtcacagtt ttcgcacccg gttttcttac accgcgcatc 1893901 gtcatgcaca tgtgttccgc ttcaaccact accattacgc catgcggatc aagcgtttct 1893961 acgatgcttt ctgcaattgt agaagtgatg cgttcctgaa gctgcgggcg ctttgcaacg 1894021 gcttcaacgg cacgtgccag tttgctgagt cctgtgacct ttccgcctcg cgggatatat 1894081 gcaacatgtg cttttccata aaagggaaca aggtgatgct cacacataga atgaaacgct 1894141 atatctttta caagaacaag ctcctcatgg ttttcaccga agatagtctg gaaatgttct 1894201 tttggatctt cattcaagcc ggagaatact tcggcataca tctttgcgac tcttttcgga 1894261 gtatcaagaa gcccttctct attcgggtct tctccgatcg cttctaaaat ttgacgaaca 1894321 gcttgttcga tttgctcttt attaacttct ttcatgttct atgtcctcca ccaatgaata 1894381 catttaattt cgattctagc acatatgccc cgctaaaagc aaagtgaatg ccctgtcagg 1894441 aagcccatgc tcttgaaata tgaaaagccc cttagaaagg ggcttttctg tgaagaaata 1894501 aagtgtatgt aagctagatg catacacgat ctatattcac aattattttc cggcaactgc 1894561 gtctttaagc gctttacctg gtttgaaagc aggtactttg cttgctggaa tttcgatttc 1894621 ttcacctgtt tgaggattgc gtcctttacg tgcagaacgt tcacgcacct cgaagttacc 1894681 aaaaccgatc agttggattt tatcaccgtt tttaagtgca tctaagatcg tatcaaaaac 1894741 agagtcaact gcttttgtag cgtctttttt agacaattcg cttgcttctg caaccgcatt 1894801 gataagttct gttttgttca tgcctttcac ctcctcccaa aaggatacat tcagttcgtt 1894861 tattatcatt tcttcacagt tcagtctgat tctaaacctg tctcagaaaa aaatgagagc 1894921 aagtaagaga aagacaatta aacggctttt taagaaaaac tgcactctga ggaatgtttg 1894981 tccaacaaag tgaagaattt ctgtatgtag agtaacacat ataaaaagcc atatcaagca 1895041 ttttaaagcg tcaatccctt gctcgtcaag gatttaaggt gatttaccga acgaatattc 1895101 ctttttttcc ttttttcatc ctattccttg atccttttcc attattaaga gcaaagaaaa 1895161 aagacctccc attctataaa gaggtctacc ggtattacag gatgatggcg attaagccgc 1895221 cagagccttc gtttatgatt ctttctaatg tttcttttaa tttataccgt gcgttttcag 1895281 gcatcaatga cagctttgcc tgaatccctt ctctcacaat tgagctcagc gaccttccga 1895341 agatatcgga attccagatg gagagcggat catcctcaaa gtcctgcatt aaatagcgta 1895401 caagctcttc actttgtttt tccgttccga taatcggggc gaattcgctt tcgacatcta 1895461 ctttgatcat atggatcgac ggagcgacag ctttcagcct cacaccgaat cgcgagccct 1895521 gccttataat ttccggctca tcgagactca tatcagctaa agcaggcgct gcaatgccgt 1895581 atcccgtctg tttgaccatt tttaaggcat cagacacttg atcatattct gttttcgcat 1895641 gggcgaagtc ttgcatgagc tcaagcagat ggtctcttcc tctgatttcg acgcccacaa 1895701 cttcttttag gatttgatca tatagatgat caggcgcgta caaatcaatt tctgccaccc 1895761 cttggcccag ctcaattccg gctaatccgg cactttcaat gaattcaaac tcgctgaatt 1895821 ggccgacaac cctgtctacg tcccggagcc gtttaatatc cttaaccgtt tccttcacgg 1895881 actcctgata gctttcacgc aaccaatggt tttctttcag caccattacc cagcttggga 1895941 gattgacatt cacttctagc accggaaact cgtagagggc ctctctgagc acactcagca 1896001 catctgattc ccgcatgctc tctacactca ttgccaatac cgggatatca tatttttcgc 1896061 ttaaatcctg gcgcatggct tccgtttccg ggtgatacgg cctgactgag ttgatgacca 1896121 taataaaagg tttgccaacc tctttcagct cttcaatgac tctttcttca gcctctatat 1896181 agtcacttct ggcgatatct ccaatggtgc cgtctgtcgt aatgacaact ccgatggtcg 1896241 agtgttcttg aatgactttt cgtgtgccga tttcagcagc ctcatgaaat gggatcggtt 1896301 cttcgtacca aggcgtattg atcatccgcg gcccgttttc atcttcatat cctttagcgc 1896361 cgggcactgt gtaacctaca caatctacta atcttatatt cacatcgagt ccgtctgaca 1896421 catgaacaga catcgcctga ttcggaacaa atttaggctc tgtagtcata atggttttgc 1896481 cggctgcgct ctgcggcagt tcatcctgcg ctcgggcccg gtctgcttcg ttactgatat 1896541 tcgggagcac cacaagctcc ataaattttt taatgaacgt ggattttcct gtacggacag 1896601 cacctacgac tcctaagtat atatcgcctc ctgttcgttc agcgatatcc ttgaaaatat 1896661 cgaccttttc caagtgatcc cctcccggac ttcctatcct tttcaatttt attaagctct 1896721 ttcaatcaaa cacaggacac tatatgtgta tgacgttgtc ctatttgaat atgacatctt 1896781 tagaaaattt ctcatcctca atctattaat ataaaaaaac ctttctccct atttgtatgc 1896841 aagggagaaa ggttcattcc tttttcatat cattttctaa aaaaacaggt tcctgtttgt 1896901 catttaccgt atattttaca gaaaacgcgg ggacaaaggg ggtttcatgc caaatcatat 1896961 cctggatttc agtcccgggt ttaaacgttt ttttgctttt tttgaggcaa gaagccagct 1897021 cagtccggta atcggcatat atttctccgt ctccgtcaat cataagcggc aaggaattcc 1897081 ctgagattgg gcttgtcact gtaagagagc tgccatcccc aagcttcttc tcatcgagtg 1897141 taaataaatc acgagatagc acatccttgt aaggcggata ttgatgctcc tgacgataca 1897201 tttggatgcg caatttcaca tcgcgaattt tttctgccat ctttagatca attaatttaa 1897261 cagtcggatc gttctctacg tcaacaagca cgtattgata gtctcccccg ctttcaaatg 1897321 ccgtacttgg aggttcagct atgtatcttg gcgctaaccg gttaaagtct atcggatatt 1897381 tttgatatag cggtgtcgac atatctttgg tttgaatagg aagcagccct ccatttgcct 1897441 tttgaaattc atcaacagca gattgaacct gctttagctg gtcttgataa ggaatggcat 1897501 gcacactgct tttccgttca tttggatata aacatccgga taaaaacacg actgccgcaa 1897561 aaatgattgc gcacttcagt ttacccatac agcacttcct tttacagctt tattcattga 1897621 cagggccgct aaaaaccacg acaaacacaa taattccaga tatgagcata cacatgtatg 1897681 cgaatgatga aatcgcaatc ttcaaaaaac ggttttggca cttaaagcgg cttaaataga 1897741 tggaagctac agccagaaac atcagaccca tggaccctag agcaaaccac attttcatca 1897801 atgccagatt caatgacgtg cgcctccccg atatgtaaga tataagcgtt atattatatt 1897861 ttaatataca gcgccggaaa agatcaacca gattttccat ccattgatag aacaaaaaaa 1897921 ctgaagcaaa gagggggacc ttcgcttcag tcaacttgac tatattcacc tgcacgttta 1897981 agaaacactc tcttggactt cgatgctata gtatgcgact tggcatacag atgcatcctc 1898041 tattgcctaa atcggcaaaa tgtttcagga gatcccaaga cttgggtgtt cttctgtttt 1898101 tcgggctttc gttcaattaa gatatgcgat tcaccatttg attgacactt ttacttcact 1898161 tgattttcaa acgtatttac caaatcctcc atctcgtggg ttttccctct cgccattaaa 1898221 gattcaacag cggtttccac tttttgtccg ttgaatagga cctgatggag agcttctgta 1898281 atcggcattt taacatcata tttcttcgaa agctgataag ccgctttcgt cgtgcggacg 1898341 ccttcgacta ccattcccat ctcttcaaga acatcttcaa gcttgtaccc ttttccgagc 1898401 aaattgcccg cacgccagtt tctggaatga acacttgtgc acgtcacaat cagatcgcct 1898461 actcctgtca atccagagaa cgtcaaggga tttccgccca ttttcgttcc gagtctcgcg 1898521 atttcggcaa gtccgcgtgt aatcaaagca gctttggcat tgtcaccgta ccctaaacca 1898581 tctgtaattc ctgcagcaag ggcaataata ttttttaaag cccctccgat ttcaactccg 1898641 ataatgtcag gatttgtgta cacccgaaaa ttgtgattaa taaatagatc ctgcacctct 1898701 tctgctgccc tcatgctctt tgaagatgca gtaacagttg tggggtgccg cagccctact 1898761 tcttccgcat gactcgggcc ggaaaggaca acgatatctt ttctgacatc actcgggagc 1898821 tcaatttcca taatttcaga aatgcgcaga agtgaatctg gctcaatacc cttgctgaca 1898881 tgaacaaaga ctgccttttt cgttataaaa gggacagcct gtctcagcac ttcccgaatt 1898941 gcttttgtcg ggaccgcaac gataatgaca tctgcgtctg aaacagcctc tttcatatct 1899001 gttgttcctt taatggatgt agacagctta acattcggca aataatcttt gttttcatgc 1899061 aactcattaa tttgatgaat taaatctgca cggtgagccc acacacacac ttcatttcca 1899121 ttatcagtta gaactaaagc cagtgctgtt ccccaactcc ccgctccaag cattgtgact 1899181 tttttcatgt ttgattcaca cctttttatt ttctagctct tgcaaatatt ttgattggtg 1899241 tcccctcaaa accgaacgcg tctctgattc ggttttctaa aaaccgttcg tatgaaaaat 1899301 gcatcagttc cggatcgttt acaaacacaa cgaagcttgg cggctttacc gacacttgag 1899361 tcgcatagta aattttcaaa cgagaaccgt tatgagtcgg tgtcggattc attgccacag 1899421 cgtccatgat gacatcattt aagacgtttg tttgaactcg aagtgaatga ttttcactag 1899481 ctttgataat cgcaggcatc agagtatgga tccgtttttt cgttaaggca gacataaata 1899541 ggattggcgc ataatccaga aattgaaaat gatcgcgaat attttcttca aattctttca 1899601 tcgtgctctc atctttgtca acagcatccc atttgtttac gacgatgacg acggccttgc 1899661 ccgcttcgtg tgcataaccg gcgatacgct tgtcctgttc aataatgcct tcttcgccat 1899721 ccagcacaac cgccacgact tctgagcggt caatcgcttt tagcgcccgc agtacactat 1899781 acttctcagt cgtttcatag actttccctt tttttcgcat acctgcagta tcgacaatga 1899841 caaactcctg ctggttgtaa gtaaatgacg tatcaacagc atctcttgtc gttccagcca 1899901 cgttgctgac aataacgcgt tcttcgccga gcatcgcatt cacaagtgaa gactttccga 1899961 catttggacg tccgatcaga cagaattgaa taacttcttc attgtatttc gtttcaggaa 1900021 tgtttttaaa atgctctgca acggcatcca gtaaatcacc cagtccgagt ccgtgtgttc 1900081 ccgaaattgg atacggctcg ccaaagccta gcgaataaaa atcataaata ttcgctctca 1900141 tttctgtgtt atccagttta ttaaccgcta aaacaacagg cttttttgtg cggtacaaaa 1900201 ttttcgccac ttcttcatca gcagctgtca cgccttcacg gccgttcacc ataaaaataa 1900261 tcacgtccgc ttcatccatg gcgatttcag cttgctggcg aatctgcgct aaaaacggct 1900321 catcaccgat atcaataccg cccgtatcaa tcaaattaaa atcataattc agccattcag 1900381 ccgagctgta tatccgatcc cttgtcacgc caggggtatc ttctactatt gaaattcttt 1900441 ctcccgcaat ccggttaaag attgtggatt ttcctacatt tggtctcccg acaatggcta 1900501 cgacaggttt acccatagta cccttccttt caatccagcc gctttcattt ttacataaat 1900561 tttcaaccgg ttattaaaat catttcattc acttttatga aaagaaaccc ttcagaggaa 1900621 gggcttaact catttattat atcagttttt actgggatca caactattct taaaaatgtt 1900681 tcacgatcaa atacacgtca tctccgattc tgtgagctat tccatcaagg atcgcctcaa 1900741 gatttttagc gaaaagctcc atctcctttt ggtcattgca aaaaaagaca ggtgctcccc 1900801 ctgcaacccg atttcgattt gtcgtgatta cagacaaaat cactttcgta agagattcac 1900861 tcatcctatc accttatcct gattcttgat aaattcagtc ggcattctaa tcgcattttc 1900921 cagggttgga acattgctaa taatttgaac agccgtttcg ggatggtgaa tttgcgggag 1900981 aacaaatact gccactctcc catcatttaa atcccgtttt gcaattggtg tcaaagatgg 1901041 ctctcctgaa tcccgataaa ccccgagcac attggaaaca tcaaataaaa tggcctgacg 1901101 ctgccctaaa tttgctatcg tcgctgctga attaaagttt ttcggcgtca aaataaagcc 1901161 catgccatgc tttaaaatca gttcctgttt ctctggaagc ccgatattca tcatataaat 1901221 attatcaaca aacagtcccg gaccgtcaaa gcgcggcttt atgtactcga tatctacaat 1901281 atccttcaac acactgcccg acataaactt catggccagt aaaaaacaaa cgacagccgc 1901341 tatgactgca gcccagatgg ataaaaacac atacgcagag gttgtcaaaa gcgctgtaaa 1901401 gatcacaata taatttctgc tttcaaacgc aatggcaatc ccctcaatat atgtgcttcc 1901461 ccttgagaca agttcatacg aatccatttg cgtcaatgtg ttccgctcca tgtttcggac 1901521 atctctaaat tgcgtcgctg ccaatgttaa aaatgtgatg gccgtaaatt cctcctgcaa 1901581 aagcgccggc ataataattg cacctaaacc agccgctatc aaccccagtg cgatgtgaat 1901641 cactttccca tgaacatagg tcggatactg gcggtaatcc gttttcagca tataaagcct 1901701 tgtcgcaatt ccggcaatga ccccagcaat aatcggatag atgtaatcac tcatgacatt 1901761 ttggtagctc ctttgtttga tcttttgctt ttctgaccaa tctggcttgc gaggtgttcg 1901821 tatttagata tgccaaacag caatatcatc cccgcagaac acgcattcag ccattgaaag 1901881 ccgccgacag ccatagcccc ggccaacttc tggatcacaa atgaatacac cagttcgcct 1901941 tggcacatcc ctaggacaaa taagacaagc tgcttctcaa aattcctttc aacagaagct 1902001 gttaaaagca ctattaatat aacagcagcc cactcaggtt ttatgatgaa ccaaaccggg 1902061 tcatataatg caaaaagata aacaaacgca tacgcggcaa caagcgtcag atagaccatg 1902121 atgtaacgaa aacgatacat tcccaaatac ccggcataga cacatccgca aacgaaaaac 1902181 atcaaatatg cagcattcag ggaaaaatat aaagcgatgt catgtatgct tagaataata 1902241 ttagttaaaa taaagacaga gacggcaatt cgtcttttcg tcttttcaaa aataaatgtt 1902301 gtcagaaccc acagaaacca cattgaccaa tagtaataaa attgttccat tttacttcct 1902361 ccatattccc agtatggagt tcaagcacat tttttaaaca atcgatctca cattaaggag 1902421 tatgatcatg ggaaaagaca gacaagagaa aaaactcaaa gcttcaggca gagtcgaatc 1902481 agatcgcgac cagtccattc actatgacgg agcgacaagc cttgaacaaa acggaagatt 1902541 caaaaagcga aaatcataat acaaaaagcc caaaccacat atggttttgg gcttttatca 1902601 tttatcgcac actatagctt gatgtattga cccctctctc tgtgagccaa tgatgggttt 1902661 cacctttgat cacaaggggc gccttttgta aatcggcaat tgttctggca cccagcacgg 1902721 tcataatcaa ctttaattcc tcaaggatca gctgaatctc ctcaagcagt ccttcctcac 1902781 cgctgtcagt cagcgctttt aaaaaatgcc ctgccattcc ggtgcaagag gcccccagcg 1902841 caattgcctt tgccacgtca agcgcatctt gcagaccgcc agaggcgatc atggtgcttg 1902901 caggaaactc agagcggatt tccgccaaac ttgcagctgt cgaaatgccc cacgaattaa 1902961 aaaaggagat ttgccgctgt cttcggagat tttcgatttt cgagaaattt gttcccccgt 1903021 aaccgccaat gtcaacagct gcagcaccag cttcatacag ctttcctgct gatgctttgc 1903081 tcataccgaa gccgacttct ttcacaatga ccggtacact gacccggctg caaatttgtt 1903141 caatgcgttt caatgcgccg ctaaagcttc tgtccccttc aggcatcaca atttcctgaa 1903201 tcacattgag gtggatctgc agtgcgtttg ctccaatcat ctcaacggct tcctttgcct 1903261 gagcagccgt tgcctcgctt cccaggttgg caaaaatcag cccgtttggg ttttcctttc 1903321 gaacaatttc ataggaaaga cgctctgatg gatcttttaa tgctgacatt tgcgatccca 1903381 cagcaagggg aattccagcc tgagaagccg ctcgcgcaag cgatttatta atctcatatg 1903441 taagttttcc gccgccgcca gtcattgcat tgataaaaat cggcgaactg cttgaaagtt 1903501 cgccgatttt tgtggaaata tctacttgtt ctaatgcaag atcgggcaga ctgacgtgaa 1903561 caaacgtaat atcatcaaga cctgtttccc gcttctggcc gatggacaag gcatgattga 1903621 tgtgttgtct ttttcgttct gctcgagtca cgtttatcac caattatttt agtttattca 1903681 gcttatctcc gatcagatct ccaagctgga agccagtgct tgtttcttcc ttcgcttgat 1903741 attgacggta atcttcctgg tcagctttag gcgtttcttc aagttcacgc atgcttaatg 1903801 aaatgcgctc ctcattttca ttcacatcaa gaaccttcac ttttacagtc tgtccttctt 1903861 caaggacttc atgcggcgtg ccgatgtgtt tattggaaat ttgagaaata tgaacgagac 1903921 cttcaacacc tggaaggatt tcaacaaagg caccgaagct tacaagacgc tgtacagttc 1903981 cttcaagcac atcgccaggc ttcacttttt cgccgatttg gttccaaggt ccaggcagtg 1904041 tatctttgat cgataaagaa atacgttcat tatcacggtc aaccgataac actttcactt 1904101 ttacttcttg tccctcttca acaacgtcag acggcttctc tacatgagag tgggaaagct 1904161 gtgaaatgtg tacaagtccg tcgatgccgc caatatcaac aaacgcgcca aagtcagtca 1904221 ggcgctgtac tttgccatca agtacacttc caacttcaag agactgaaga agttcttgtt 1904281 ttttattcgc ttgttcactt tcaacaacag cacggtgtga aaggatcacg cggtttttat 1904341 cacggtcaag ctctacaacg agcagtgaca gtgtttttcc tttatagtca gtgaagtctt 1904401 caacgaaatg tgcttcaaca agtgatgccg gaataaaacc gcgaacgccg atatcaacga 1904461 caaggccgcc tttcacgaca tctttcactt cagcttcaaa cacttctttt gtttcaaatt 1904521 ttttctcaag gtcttcccaa gcgcggtctg catcaacagc acgtttagat aaaatcaaag 1904581 catcgtcttc cacttttgtt actttcaggt caagctcgtc gtctacttta acaacatccg 1904641 atgctttctc tacatgaaga cttgataatt cactgattgg aataataccg gattgtttga 1904701 cattgataat ttctacatct acatgtttgt cttctacctt tgtcacaatc cctttaacta 1904761 catctccaac ctctggcact tgaacatcaa tttgattcat ttcctctgtc atttgaataa 1904821 cctccttggt ccaaacctac acagcttaat taaaacggtt tgaaagctga acatataaca 1904881 tgcccgcttt tagccgaata tgtattaaag aatcatccaa aaaagttttt tgaatgatca 1904941 ataaaaagtt ttattagtat taacttctaa taaaaggaca ggtttgtcaa gcaataacat 1905001 tctatcttcg ttgaaaaatt caaaaaaagt ggcatttgcc atcctcagcg ggacttttgc 1905061 tccacagcct cgaggatttt atcagctacc tcttgaatgg aaagcgatgt cgtgtcgatt 1905121 tcaagagcgt cttctgcttt acgcagcgga gatacttcgc gctctgaatc aagcttgtct 1905181 cttcttgcaa tttcctcaat taatgtttcg tagttgacat caaagccttt tttcacattt 1905241 tcttcataac ggcgtttcgc tctctcttcc acagatgcca aaagaaagat ttttacttct 1905301 gcatttggca gcacatgcgt cccgatgtca cgaccatcca tgacgacgcc gcctttttcc 1905361 ccaagctgct gctggcgttt caccatttct tctctgacac ttctgtgctt ggccgcaatt 1905421 gaaacttggt tgctgatttc atctgttctg atcgcctcag ttacatcggt gccgtttaca 1905481 aacacttttt gtccatcttt tgttgtaatc agctcaatgt ctgtccgctt tagcagctca 1905541 gccagttttt cttcatctgt cagatcaacg ttttcctgta aagccgcgta cgtaatcgcc 1905601 cgatacatcg ctcctgtatc aatatatatg tacgattttt tctcagccac aattttggca 1905661 acggtgcttt tccccgcagc tgccgggccg tcgattgcaa tcgataattt cttttccata 1905721 attcctctcc ttgctctttt ctcctctaag gattgtatca cgaactttat gaaaaagggt 1905781 gaaaaattga tgaataatta atgtttgaag gtttcaatcc tattgttttc ctccatttta 1905841 tccacccctt catattgaat cacttttgat acgtatggtt caatatgctg atagtgaaaa 1905901 agaaattgga caccaagtaa aatgatggcc tgaatgaaca ataatttgat cagcagccgt 1905961 tcaaatgttt tcattggagc acctccatta caaatagtat ggaagtgttt gccgatgttt 1906021 attccattcg ggcctttctt ctcttattta actggcgcct gatgcagtat tgaagcaaag 1906081 cctgctggtc acctgctgca atttctgaat actctaaagt catttttcgt ttttctgact 1906141 tggggtcatt aaagattcgt ctgacaactg cttctgtttc tatttgacgt gtgtgctcct 1906201 cttcaggaag acggatgatc aggcgcaatg attcccccga ttgaaaagaa aggccatcag 1906261 ctaaaaccac ggcgatgccg cctgcactga tgttatagga tagtgtgcgg atctcttctt 1906321 catttcccgg ctgaatttgc acatctaata ccgcatcagt tcttacatat tggcggcgct 1906381 ggattctttt cattttttca cggggaggca tttcaagaca gatcatttga agtttgtcct 1906441 tcactttacc ttttatacgg cttataaagc gataaggaac ttcgtctttt cccacaaact 1906501 ctaccgttac ttccatatcg ttatgtaaaa tcacagttcg ccctgtaact acatcaacag 1906561 gatacgcgat caaaagttca ttgttttcga tgctgaccgc cttgcttttt gcctttttca 1906621 attcattttc ttctatatat tctaaaagta cattttctcc aatctctatc attgacttca 1906681 ctctttcgca ttcaatatac tcacgttttt attaaagcac gtaatgaaaa aaaggaaaag 1906741 acatttagtc ctttcctcct gtttttatag gtctttatat ataggttctg cattttttag 1906801 tttttcaacc ttttcttccg atccgtcttt ggcattgata tacattctga atgtgtcatt 1906861 ttcaattgtc ccaagcattt cgtagcataa cacttcttga cctagttcat ttgtaatcaa 1906921 agcgagcctt gtttctctca cttgtacatt tttatttaat ttagactttg cctctgcttc 1906981 agtaattgca ggcttaggta tggttctttt tctgtgagat gtgaggaagt ctcttgctga 1907041 aaagccgaca acctcaccgt catccaaggc cactttcata cgaattgcct cggggtacat 1907101 ccggacttta ttttcaacag gaacatatga aaatacaccg attttatcat attgggcact 1907161 ttcatcaatt tccaaatcat ctgtttcaaa tccgtttttc tttaaaaatg caagcgctcg 1907221 gttcgatccg tcatttaaac tgattttctg atctttcact tctctgtttt ggatcaagta 1907281 taccggatgc ccgcccttct tcgtaatatc catataaatc actgctttat ggtctgggtc 1907341 tttcatgctg atgctatata catcgcgatt tgtttttttt ccgctcttta ccactttaat 1907401 tgaataattg tcatctgggg caaagcgctc agcaatttgt tttgcttcct gttcggaaat 1907461 ttgttttccc ttcagatggc tgaagccttt ctcttctttt ttcgtactgg tgaaactcgg 1907521 gccaagatca gtgccagtgg agaatgcacc aacatttttt tcgactgttt taaagctgtt 1907581 gataatcgta ttatcacttt gtttttcgtc agaagccaga gccatttcta cgtccatcca 1907641 gcgaaggttt ttgctcatga caaggtgctg aacatgacgc aattcatttt gtatatcttc 1907701 ggactgctga tatagcttat ttagtgatgt atactcgttt ttatcaagcg gcttttggtc 1907761 caaatctctg actgacgttt tatagctgaa atcgccgatc tttgataata gctcttcagt 1907821 tttattaaac ggcattaatg taagcggcag ctgactgacg ctgttatgag cttctgatgt 1907881 aatcctccac acatcgatca atgcaggcga cagtgatttt tggctgttca tggcaagtgt 1907941 tgttccgatt ttatcatgaa gctgatccac ctgataggta agctcatgaa acgcccgctg 1908001 atagttattt tcagcatgaa gaagaactgc gtctttttcc tggtgttctt tgtatcccca 1908061 gtagcctgta ccgactattg caataccaag cacggcgatt aaaattcctc tgatcattta 1908121 tcacacctct ttttatgctt tctcatatct gctactcaca gaaaatgtgt ttaccgattc 1908181 ttttaatctg cggacgcccc caaatccacg gacttgtagc cgtatccgga ttaaagtagt 1908241 aaagtgcttc ctctgatggg tcccagccat tgatggcatc cagcactgct tctcgtgccg 1908301 tttcattcgg ctgcatgtaa atttgtccgt cggctactgc tgtgaaggca agcggctcaa 1908361 aaataacccc cgctactgaa tttggaaata acgggctgtt caaacggttt aaaatgactg 1908421 ctgcaatagc aacctgcccc tcgtacggct cgccccgggc ttcgccataa accgcttgag 1908481 caagcagcct gatatcgttg ttggaaaatc caccaggcat gttcgctgct accgcatcct 1908541 gttttcttgc ttttgctggt gtattgtttt gctgtttatt cgcattcgct ttaggcttct 1908601 gcgttgtttt ttccgcaggc tgtttctgcc gtgcttctgc ttgttgtctt gccttttgtg 1908661 ttgctgcttt tgatggtttc gtctgatact ttagcggaat ttttccgtaa tgcgtgaatg 1908721 tattcccttt attgagctgt tccatgacat attcacgata gtattttgat ttacatatta 1908781 aggtttgctt tgttttagct cctacaaggc cgtcaacctc ttttaacccg aattgatcct 1908841 gaaaatttcg aactgcccag tacgtccccc atccataaac cccgtcaatt tttccgttat 1908901 aatatccgtt gtattgaaga cgcgcctgaa gctcgaccac atcatcccct gttgcccctc 1908961 tttgaatgac ctgattcgaa aaggcagaga tcgtttcagt attaataaac gtcgttattg 1909021 taaaggaaaa aaggatgaga catgccataa tcgatccttt ggacttcatc ttttcaagcc 1909081 tcctactgca aatttttaag tgtaatcgta ttttctgtaa cgaggttatt tttatacact 1909141 ctttccttgt tatccctcag aacataaaaa ctgcacacaa aaaagccgca cggttgctgt 1909201 gcggcttcta tacttgcatc atattaacgg aacgggcttt tttcgcttta cgcaaaccaa 1909261 accaccataa aaataccata aatggaagca tataataaat ccaattgcta agcgctgtta 1909321 ggataaaatc atatgatcca tgcaaaaggg atgggacaac taaagaaaga gtaagccact 1909381 ttacacgcgc cttatcagcg gaaaaacggg cttttccaag gtaaaatccc attataacgc 1909441 caatcaaggc atggcatgaa acaggcagca gcgccctgac aaacgcatgc tccacgccgt 1909501 ggccaattaa ataaagaata ttttcgaggg ttgcaaaacc gagtgataca cttgcaccgt 1909561 acacaatccc gtcataatgc tcatcaaagt gggcgtgcgg gtaaacactg atcatcagta 1909621 taaaccattt taatgattcc tccaaaaacc ccgaagataa aaaagaaacg aaaaagcttc 1909681 cgcctcctac attctctttt tcaagtacat actggataaa catgatggga aatacaagaa 1909741 caaccccgag aaaaaacgac cgtagcacca tatgtacagg ttcattatca tactgatctt 1909801 ttaaataaaa ataacttaat aacgcgatgc cgggggcaat tcctgcagag atgattgcaa 1909861 acatcaggca acctctttcc tttatattcc tacatctatc ctaccatgtt gtttaaaatt 1909921 ttacatctgt ctgcacttaa aaaaacaaaa agagcatacg aatgcatcat atgctcctca 1909981 tctttaatgg ttttctcttt tggcgatttc cgctgcgata tgccccccgt gaaacctgcc 1910041 gttttcaata aatatttcat ttgcattgtt tcccgcagca ataacaccgg caataaagac 1910101 accttcaacg ttcgtttcca tcgtttcttc gttgaaaaat ggacgccctg tttctttatc 1910161 aatttcaaca ccaatttttt caagaaattg atgatcggga tgatagcctg tcatggcaaa 1910221 tacaaaatca tttttaatgg taatgagttc tttctctccg gagcgaaaca caacttcatt 1910281 ctcggtgatt ttttcgacac aagctccaaa ttccatacgg attgtaccgt ttctgacgag 1910341 agcttcaaat tccggcagaa tccacggctt aatgctcgga gaatactcat tgcccctata 1910401 taaaactgtg acacgcgccc cagatttcac gagttcaagg gcggcgtcca cgcttgaatt 1910461 tttcccgccg atgacaacaa catctttatc aaaatacggg tggccttctt taaaataatg 1910521 aaatactttc ggcaaatcct caccgggtac gcccatatag tttggatgat cataatagcc 1910581 tgtggcgatg atacaatatg gcgtcgtgta ggtctctttt gacgtctcaa taacgaatgt 1910641 gttattttgc gttttcgtca ctttacgcac catttcaaac gcattaacac ggatgttttt 1910701 ccgtttaacg acttcccggt aatacgataa agcctgaatt ctgacaggct tcctgttctc 1910761 tgtaataaat gccacatctc cgatttcgag cttttcactt gaactgaaaa aggtttgatg 1910821 cgtcgggtaa ttgtaaatac tgttaacgac attgcctttt tcgatgacga gggcatcaat 1910881 gccaatttgt tttaggtgaa tggcagcaga tagtccacaa ggtcctccgc ctataataat 1910941 tgctttttct tgaatcattt ctgtcaactc ctgcgattgg catttcactt catattttct 1911001 atttccgaat aaaaaaatct cctattttat cataggagat tttttatttt tatgcaaatc 1911061 atcaacttat atccagcctc taaaacgcga agcttcagcc attttgcgaa cgccgaccat 1911121 atatgcagcg agcctcatgt caattcttcg gttgttagcc atttcgtaaa tattgttaaa 1911181 tgatttgacc atcatttttt ctaatttttc ttctacctct tcttcactcc agtagaagcc 1911241 ttggttattc tgaacccatt caaaataaga aactgttacg ccaccggcac ttgccagcac 1911301 gtctggtaca agcagaatgt cccggtctga aagaattttt gttccttcaa gcgttgttgg 1911361 tccgttcgct gcttcaacga caattttagc ccggatatta tgggcatttt cttctgtaat 1911421 ttgattttca atcgcagcag gaacgagaat atcacaatcc agctccagca gctcttggtt 1911481 ggtaatggta tcgttgaaaa gctttgttac ggtaccgaag ctgtcgcgtc ggtcgagtaa 1911541 ataatcgata tcaaggcctt ccggatcata aagtccgcca tacgcatctg agatgccgac 1911601 aacttttgcc cccgcatcat gcataaattt tgccaaatag cttcccgcgt ttccgaagcc 1911661 ttggacaacg acacgcgcac ctttaatatc gatgcctctc ttcttagccg cttctttaat 1911721 acagatggta acaccttttg ctgtcgcaga ttctctcccg tgagatccgc caagcacaag 1911781 cggtttgcct gtaataaatc caggcgaatt aaattcatca attcttgaat actcatccat 1911841 catccaagcc atgatttgtg agtttgtaaa tacatccggt gccggcacgt cttttgtcgg 1911901 gccgacaatt tggctgatcg ctctgacata ccctctgctc agacgctcca gctctctaaa 1911961 cgacatatcc cttggatcac aaacaattcc gcctttacca ccgccatatg gaagatcaat 1912021 tatgccgcat tttaaactca tccaaattga aagcgccttc accgccttca cctctttttc 1912081 tgttacgttc gggtgaaaac gtatcccgcc tttcgttgga ccgacagagt cattgtgctg 1912141 cgcacgatat cctgtgaaaa tctttactga accgtcgtcc atacgaacag gtatttttac 1912201 cgttaataat ctcatcggct cttttaacaa ttcgtatacc tcttcgggat atcccaattt 1912261 ttccagagcc ttatgtatta cggtttgggt tgattttaat acatcaagtt tgtcctcttc 1912321 tgtatgaccg gtgtttcgat cggctgccat ttgagttaac ctcctagaat cttctgtttc 1912381 tcacatgctc cctttcagag aatagtatac accttcatat gatctgtgca tagaataaac 1912441 gttatgtttt tccatgtttt ttaacgaaaa aaaactgctg aaatcagcag ttttccgttg 1912501 cattcttatg aaaaatgagt ttgtatcgtt tctacggcat taccgtccat aatgagctta 1912561 ccatactctt gcaggcgata aatcgttaaa gttgtcggat tgccgtattc agccagaacc 1912621 gccacaaccc cttcagccgt atgtgaccct agatcttcaa ggcttaaaaa gtactgcccg 1912681 tcatagtggt agacagttcc ccctgtgata ccgattcgct gtaagctttc tgaaagctga 1912741 atgatatctt caaaggaatg gaattgatat atgatgtccg cgctttcatc aagcttgact 1912801 tgcatttcga tgtaatcatc atcatactca tcgtcttctg aatcggcgtc ttggttcttt 1912861 gttacaatca cgaccatccc ttgtgcttgg agagaataca cttccactgc aatcggtcca 1912921 ttcgcttcaa agccgagctc tgtatttgct tcattcatca tatctttaaa taactggtgg 1912981 actttaaatg agtccttcca gaggtcttct tttgtcaatc cccggtctgt caaatcatcg 1913041 agggttaaaa agattttgat cttattataa ttcagacgct caagccgcat aacgttccct 1913101 cctgcctcta cttgcacaca aatcatataa cacattatat gagatgatga gtcataggtt 1913161 cttaattgtt atcagtttac actgagttca ctagtaagac aagcacaatg cagtttttat 1913221 tgccatacgg atttttgctt tttagaagtt attctggccc gcaaagagtc acaatgtgag 1913281 tttcaggctc agcacctaaa cgaagaggca cttttgtcgt gccgtagccg ttgctgatca 1913341 gatatgccgc gtttttaaca atacctgttt tccccagttc ataaggaccg aattttccaa 1913401 acctgatctg gcctccatgg gtatgtccgc tgagtatcac atcaataccg tcatcttcat 1913461 tgatttgttc atgaatctcc ggattatggc aaaccagaat attcagctgg ctttcatcaa 1913521 gttctttgat ggcttcctca taatgatcca tctccatcct gatatcatca acccccgcaa 1913581 tcgcaatcgt atgcccattg tatgaaaacg ggactgactc atttctcaga gtgatgacgc 1913641 cgtgcgcttt aaatatggaa tacagcttat gctgcctgac ttcataatca ttattccccc 1913701 acacaaacac gatagggacc ccgaaatgta cgagcctttt gatgttttcc tcgattctcg 1913761 cactgggcac cccgccctca gctaaatcac cgccgattat aaccaagtgg ggggcatggc 1913821 ttcgcgcttt ttctaaaagg tcttgatcga tgagacgttt gtgaatgtct gaaataaaaa 1913881 agattgtcag aggcggcttg cccttcatct ttgataaagg aaacgtatgt gtcttcaaat 1913941 gattgccttt tgctgttgca tacatttttg ccgtcattgc cgctgccgca acagttagta 1914001 caccggcaat tttcactgat agcttcataa aaaactctcc attcttttta gaacttatca 1914061 ataagacgga caataaaaaa agacgtttct atcgtttgag aaaacgcccc attttattta 1914121 ctttcaaaat atagattaat gtcatatttg tgcttcatca tatgaaaaac agactctctc 1914181 gccttccatt tatcgggctg cggccagaga tcagtgcttt tctgaataat ttcacatctc 1914241 agtttatgga aatcagtctc ggatttttct tcctttttct tgaaataata tgaagtgcag 1914301 taggcaaaag cggttgccag catccaaaat aaataaaagg tatggctaag tatttcttga 1914361 agtataagct gaggctccgg gcttttgatc atgatcataa cacataataa gcctaggcag 1914421 ataagtgaag cccatcgcca tctgcggcat tgtgctgcat aattttcgaa tttttgtttt 1914481 cgttttacca gcgcttggag catctgtttg gtcggcgcgt ctgtaaactg atccagctga 1914541 ttccataagg attccatacg cttcacacct tgtccatttt cattgctaca atatatgaac 1914601 gtaaaataaa aataataccc tattcatcca ttaaagggat gtccaaaact tgtccggtgt 1914661 aaacatcatt tccattcaga tgattatatg ctcgaatttt ttcttctcct gtccggcttt 1914721 tataatactt catggaaatg cggtatagcg tttctttctt ttggacggtg tgcttgacaa 1914781 cgcgattcgg cacattttga actggctcag ctggctgttc ttgctgttgt actgttgatt 1914841 gggaagagga agcagccgcg gcggttgctt cctccttatt tggcgagtct tctttttccg 1914901 ctacagcagt ctgtttctta tcagcagctg tttgctcttt tggcttggaa tcttctggct 1914961 ctttttttga ctccttctgc agtgcggttt ctttagtgtc tgcggtatcg tttttatcct 1915021 ctgatttcgg gacaacctca tatttgcttt ggctgctgtc aataaaaaca tcttcataat 1915081 cgtcatgatt atccgggtgg ctctttagat aaaataaggt gactaaaacg ataaccggca 1915141 caaatacaaa tattactgcg agtactgtga ataatggcgt ttttgttttg ccttgctttt 1915201 ttttctgttc tctttgattt tttacagatt gtcttgtcgg aaggctttct ccatcatcga 1915261 cataatcgtc cgccaatgcg gcgttttgat cttcataaag attctgggct tttcttctct 1915321 ctactctcga catgttcgtc atgtttatcc ctcctcacat gttcaaaacg aatctgacag 1915381 gcaaacacgg catcaatgat aaaatgcgcc gtcatcggaa caaataagtt gccggtccat 1915441 tcatacatca gaccgagcaa aaagctgatt gctgtcacca taataaataa cagccatttt 1915501 gacaaatacc gaaagtgcag agcggcaaat ataaggctgg ccgtccataa accgatatga 1915561 gtctgcagca ctcctctgaa taacatttct tccgcgaaag caatcagaag cgttaaaaat 1915621 ataatatgag ggattgacct cttactgaat atttttttat tgattccgcc gtcatcatat 1915681 aaatgagacg gaaaccattt cattactgcc atatcggcta aaataacaat aacagctata 1915741 gaaacaccat accagatgat tcgcatatcg cgaatgtccc agagctttaa tacgtcccgt 1915801 acatcctcaa aaaagaacag tcctgctgca gcagcggcaa agatgatgag tagctgcgtc 1915861 aaatataact gcttcagcat atcatggtca gtcatatgct gaatataatc tttttgctgt 1915921 ttcagttcag ctcacctaca gtctgcaagc tgaatatccg gtgcaattcc gaactccagc 1915981 tgtctaatgg cgccatttta ctccgttccc ctttttgttc atacaaggat aaatcaaaac 1916041 cgcaatgtga acagcacggg aggtttccgt catcaggctc gtatgattca tcaaagtagg 1916101 ttaacagtgc ctgccttaaa cagccgtcac gctgaagcaa aaatgataca cggtgcattt 1916161 tttccagctt cagctccatg cgatatgaaa tttctttctt catcagttca actgatgttt 1916221 ttccctgcat aaagagatga atcatcatac gggcctgtgt ctctccgacg ccatactgaa 1916281 gtaatacgtc acgcagcctt ctctcatccc gctcctccgt cttctctagc acacggatta 1916341 cgtcggcgat ttcttcagct gtgacactct ccatctggat aatttgttcc tgcaattcaa 1916401 aatcccctgg cgcccgcagc aaaatgctga cactcggctt tccgtcgcgt cccgctctgc 1916461 cgatttcctg cataaaagct tctgccgtct gcgggagatg aaaatgaatc acatatctga 1916521 tatcaggttt atcgacaccc attccaaacg cattcgtaca acatatcaca tcaagctggt 1916581 tatgaataaa ctgctgctga attaaaatcc tgtcccctga ctccaaaccg ccatggtaaa 1916641 agtcggctct gctgctcgtt ttgcttttaa tttcacccgc taattcctta gcccatttcc 1916701 gtgttggaca ataaacaatt cccggacctt gcaggttttc aaccagctga atgaccctat 1916761 ctattttttc ggcagtatcc gccgcatttt caaccctcag tgcgatgttt gggcggttga 1916821 ctgagttgag atggcgtaca gcatgctgca gctccagcag gttcatgaca tcttgcagcg 1916881 tttcctttgt agccgtggcg gtcaatgcca gaacgggtgg gtgtccaagt ttttttctca 1916941 gctgtccgag ctttgaataa tcaggcctga agtcgtgtcc ccattcagaa atacaatgcg 1917001 cttcgtcaat aacaaatagg ctaatcggaa cgcttttcaa tttttccaat acatatggag 1917061 actgtaaagc ttcaggagac aagtacaaaa atttatatcg atgaatatgt tctaaaacaa 1917121 attgtctttc ctgcctgtta agcatgctgt tcaaagctgc agcacgcttt tccccccggg 1917181 ctttgagctg ctgcacctga tcctccatta aagaaagcag tggagaaacg attaatacca 1917241 tgccatcaag catataacca ggcagctggt agcaaagcga tttccctccc ccagtcggga 1917301 gcattgcaat ggtatccttc ccgctgagta tgctttcaat aatgtcctgc tgcccttttt 1917361 taaaggaagt aaaaccaaaa aactgatata acgtttgctg taatttagtc atattgctgc 1917421 acctgctttg tcaatgccag tctgatttga aagtagctga accgctgttc cagcccgtcg 1917481 cgaatttgtt tgattttatt cgtccgcatc cgtttggcaa actctgcgat ttgaagctgg 1917541 tcttctgctg atacatagtc attaatcata aacgcaggct catggagaga aatctcgaca 1917601 atgtggtctt caatcgtcgc tgttttcagc tttctgattt cagcaattcg ctgtatcgga 1917661 aacccttgtt tgaccatctg ccatgttttc ctcgtcgact ctgtcagggc attatctaag 1917721 tgcacatcag aaaggagatc ctttaacaaa gcatcttcac actccggaag agaatgaata 1917781 aaataatgta ccgaagccca aaacatgata tagacatacc attcgtcttc tttcagcgta 1917841 tcagcaagct gcctgctcgt ataaccgatc cgatggtgcg aggttaagga gtagacaaaa 1917901 atttgcgctg ctttgttttc aatctttttc aaatgcgcct caagcatggc aaaaaggctt 1917961 tttgccatct ctatatgatc cgtatgccgg gacaggtatt tctttaccca gtgaagtgtc 1918021 ttatgatcct ttgtgacagg gatatactgc ctgctccctt gctgtttatg ggataggacc 1918081 tgcacaagca gcgaaagcct tttccaaagc acgccggcag cctgctgata atgagcgccg 1918141 tgacaatgaa cgggccaagg ccgctcgcta agggcatgtc tcaaaactgc tgcgccgctg 1918201 gctgtcactt tgtatgtatc tgattcagac attggcgcga gatatgaatg cttttcaagc 1918261 ttgtcaagcg acgcagaaat atcgcttctc gaacattttg ccgccattcc aaagtatttt 1918321 gcagtctgaa ataagccggc atcttgaatg gtctgtgacg atctcttgcc tttgaatagg 1918381 tgaaaaacag cgcttcccga ccgttccccg tttattttgc aaagacaatc gagaaccata 1918441 atatcgaagt aatttaatga caacctatcc acctacattc ttcctgacaa aaatcgttga 1918501 tttgctcttt ttattttaac agatttcaaa cagaaatcga cgtttaaagt catcattaag 1918561 ggggatgtta tgtagataac cccttatgtg ataagcattc tcaatcattt ttctgttgaa 1918621 atgtggcagc aacatcatta caataagtaa gaggaatagg tgttaaattg attaaatata 1918681 aagattgatc catttgttcc accaagaaca atctgggagg ttttattcat ggcaaagtac 1918741 acaatcgtag acaaagatac atgtattgca tgcggcgctt gcggagctgc tgcaccagac 1918801 atttacgatt acgatgatga aggcatcgcg ttcgtaacgc ttgatgaaaa caaaggtgtt 1918861 gtcgaagttc ctgaggtact ggaagaagat atgattgacg catttgaagg atgccctact 1918921 gattccatca aagtggcgga tgagccattt gaaggcgacc cgcttaaatt tgaatagaag 1918981 taactaaaaa aagctcccga acgggagctt ttttatttaa tggatatgtg cacttcgctg 1919041 ctgctcaatc catggcttaa gcttgataaa aattagtgag aatacaaccg taattacaat 1919101 accttttatc atgttaaacg gcaggatacc tgcgacgact gctgttttta gcgcgctgtc 1919161 ggataatgcc ggtgaatgta aaaaccacgt gtatgccgga agaatcagaa cataatttaa 1919221 aatactcatt aaaatggtca tcgctgcagt tcccaaaagc aggctgacag ccaagccctt 1919281 tgctgagttg agttttttaa ataagaaagc agtcggtaat ataaagagtg ttcctgcaat 1919341 aaaattcgca acttgcccta caggaactcc ggccatgctt ccctgaatga tatactgaag 1919401 aacatttttt atcgcttcta cggcaatacc cgccaaaggt ccgtaaatca gaatggcaat 1919461 aattgcggga acgtcgctaa aatcgatttt taaataatcc ggaagacccg gaaacgggaa 1919521 atttaacagc atcaaaacaa atgcaatgct gctcagcatg ctgaccacaa ctaatttttt 1919581 tactttcact tcattctctc cttttcgatc acatcttact cgaaaacgga aaggttcttt 1919641 tccagccaat aaaaaaaccg cttcatatat aaaagcgggg tttcgaaaat taggctaggc 1919701 aaagaaacgt ttgaaaaatt caatttcaaa acgcttatga acctccatct tctcccatcc 1919761 agactgtact gtcggctccg gaatctcacc gaatcctgct gtaaagacag ctcgcgggct 1919821 tagagccatt ggctcatcac cgccggtagg gaatttcacc ctgccccgaa gattgatcat 1919881 atgaaattta attacattat aaacgataac tggttggctg tatagagaat tgcttcaaat 1919941 taaatatatt acctgcaagc tgtcagatca ttgatttatt aggctttact tttatccttt 1920001 actgcgtcaa tacacgttga cactcttttg agaatatgtt aaattatcag atatttagtt 1920061 tgtcaattta ggaggaaatc taacgatgtt tcgagtattg gtctcagaca aaatgagcaa 1920121 cgacggttta cagccactta ttgaatcaga ctttattgaa atcgttcaaa aaaacgtagc 1920181 agatgcagaa gatgaattac atacttttga tgctcttttg gtgcgaagcg cgacaaaagt 1920241 aacagaagac cttttcaaca aaatgacttc tttaaaaatt gtcggaagag ccggtgtcgg 1920301 tgtcgataat atcgatattg atgaggctac gaaacacggg gtaatcgtga tcaatgctcc 1920361 gaacggcaac accatttcga cagctgagca tacatttgca atgatctctt ctttaatgag 1920421 acacattccg caggctaata tctcagtgaa atccagagag tggaaccgca cagcttatgt 1920481 cggttcagag ctttatggaa aaacgcttgg tattgtagga ttaggccgaa tcggaagtga 1920541 aattgcacag cgtgcgagag cgttcggtat gactgtgcac gtttttgatc ctttcttaac 1920601 ggaagaaaga gcgaaaaaaa tcggcgtaaa cagccgtaca tttgaagaag tgcttgaaag 1920661 tgcggatatc attaccgttc acacgccttt aacaaaagaa acaaaaggct tattgaataa 1920721 agaaacgatt gcaaaaacga aaaaaggcgt tcgcttaatt aactgtgcgc gaggcggaat 1920781 tatcgatgaa gcagcacttc tcgaagcttt ggaaaacggg catgttgcgg gagcagcgct 1920841 tgacgttttc gaagtcgaac cgccagttga caacaaactt gttgatcatc cattagtcat 1920901 tgccactcct cacttgggag catcaacgaa agaagcacag ctcaatgtcg ccgcccaagt 1920961 gtcagaagaa gttctgcagt tcgcaaaagg cctgcctgtc atgtcagcta tcaacctgcc 1921021 tgccatgaca aaagatgaat ttgctaaaat taagccttac catcaaattg caggaaaaat 1921081 tggcagcctt gtatcacagt gcatgaaaga accagtacag gatgttgcca ttcaatatga 1921141 aggcacaatt gctaaacttg aaacatcgtt cattacaaaa gcccttctgt caggcttttt 1921201 aaaaccgcgc gtagactcta ctgttaatga ggtcaatgcc gggggtgtcg caaaagaacg 1921261 cggcattagc ttcagtgaaa aaatttcctc ttctgaatct ggatacgata actgcatcag 1921321 cgtaaaagtg acaggagacc gcagcacctt tactgtaacg gctacgtata ttcctcattt 1921381 cggagaacga attgtcgaga tcaatggatt taatattgat ttttatccga ctggtcactt 1921441 ggtgtatatc cagcatcaag atacaacagg tgtcatcggc cgagtaggac gtattctcgg 1921501 agataatgat attaacattg caactatgca ggttggccgt aaggaaaaag gcggagaagc 1921561 catcatgatg ctttcctttg acagacatct ggaagataaa attgtgaaag aactaacaaa 1921621 tgtccctgat attgtgtctg tgaagctcat tgatctgcca taattaaaaa aactcaagct 1921681 atatagcttg agttttttta ttgttctatc cccgtgtgtt tttatgcaaa atatctaaga 1921741 cactccttag ctcagaaaca ggaatttggc ctggtgcgga cgcctcttct ccagctccaa 1921801 aagtacaagc cgatccaaaa acctcaccgc tcagcctgct gatgagccct gttgcagcca 1921861 ttgacattgt aataatgggg cggtctgcat atattgtttt cattgtatac gtcgcatcaa 1921921 gcagtgttag gagatctcca gtatcattcg gcatgacagc catttttgga atatgcgcgc 1921981 ctaagtcctg catttttcga agtctggaaa taatttcatc ttttacaggt gttttttcaa 1922041 agtcgtgatt tgacatcacc acatagacgt tgttttcttc cgccagcgat actaacgctt 1922101 ttacatttgc atctcctgaa aataattcga tgtctatcag atcgatgtct tttgtttgga 1922161 ttgccgattc cagcaaagca agataggagc tttcgtccat ctccatgctc ccgccctctt 1922221 tgtgggttct gaatgtaaat agaaatagct tgtcttctaa agatttacga agcttagaaa 1922281 tgagctttgt gaccgcttct ctgtcattcg ctttttcaaa tacgtcgact ctccattcaa 1922341 caatgtccgg attcagtaat tttactgcct ctgcttcatt cagaatttgt ttttccgtct 1922401 ttcccatcag cggaatgatg attttcggca tcccttcccc gatggaaact cctttaatcg 1922461 ttaacacgtt cactcgtctc aaatcctttc aatctttacc ttgttttatt atacacgtac 1922521 aacttttttt tgaaaatttc tattatatga atagcaacta aaaaagagcc ttaaagggct 1922581 ctttttagtt taaggaaatc ggatttggag cagctggcac cggaattgca tctgatatgt 1922641 catatttgcc gatttttttc gttctggttt ccgtaaaggt cacttctgtg aagccaaact 1922701 cttttgcagt caaaagtagt ccctcaatca ttaaaatacc ggcaatagaa tcatcaactt 1922761 ctgactcctt tgaaaagcgg atatataagt gtttctgttt cttcgttaca gattggacag 1922821 cacccgcttg aataagaggt gtcgtatctt cttggctgct cgattccatt tccttaatcg 1922881 cttcttttac tgtatcaaaa gaatgatttg acggaacgag aaagtcttgt ccttgtttat 1922941 tttggtacaa gtagtaggat cgttttgact gtttgggaat cgaaatttcc gtaaaagtgc 1923001 catatgagcc aatccgaacc ccagtctcat tttgatccga taaaaatttg actttttcat 1923061 aaggactcca ttttaaggat tctttaagca atttttttaa cagtgtatca tcttttatag 1923121 aaaatgccgt agctggctga tggactcgta tacttaattc cttctgcttt ggtttttcct 1923181 ttatttctac ttcatctatg aaggttggaa ttgtaatggc atgatcaagg atgcccaatt 1923241 cactactttc aaacagcata tcctggatcg tttggtctgc atttgttttt tgaatgctga 1923301 cgggtatgat tgcagatgta tcggcatcag caaccgctac agtgatgtaa ttgtcttgtt 1923361 ccttttcagg aacgacaaac gatgtctgat ccaaggacga tgcagctttt gggctgtctt 1923421 ctgtctcagt tttcgttact gcgttctctt gggacgcttc tttttgttga ggctgtgcct 1923481 gatcaaagaa atgaggagaa ataatgaagg cgatataaac cgcaattgca gcggcacacg 1923541 cggggccaat ccacctgaca gcgggcttat ttttacgctt tgccatcgtc agccgcttgt 1923601 aaatatcctg aggcgaacga tggtctttaa ctgccggaag ttgacttaac aactccttta 1923661 tctgttcttc gttccattct gacttcatca tccattagct cctccctcaa aagctccata 1923721 tgtttccgaa gtactttgag ccctctgtgt tgggtcgttt ttactttgct ttccgagaag 1923781 cgcagagcct tggctgtttc ctgtattgaa tatccctgaa taaaccgcaa gataatcaca 1923841 gctctttgat cgattgtaca ttgatcaagc gcagcataaa tttcccggac attttcatgt 1923901 tgaaccgcaa gttcgtccgg cagcaattgc tgatccctga catcctgtgt atcccagtca 1923961 aatgtaccga gtatacgctg tctgattgtt tgctgtttac ggaaccagtc tatcgcaaca 1924021 tggcgtgcga tagacaaaag ccatgttttt tcactgcttc ttccttcaaa cgtatgataa 1924081 gaatttaata cccggatata aacctcttga agaaggtctt ctgtctggtt tttatccttt 1924141 accatataaa ataaaaattg gtacaaatct tgatgatatg tatcatataa taattgaaag 1924201 gtttcttcca tttgaaaccc ctccgttcac ttttttgtcg tatgaatagc ttgaaaagtt 1924261 acattacaac tatattacga gtaactggaa tttggaaggg aatttatatt aacatatcct 1924321 taaattttat taatgttggc tattaaaaaa acacccgctc agtcagcggg tgtttcttat 1924381 ggaacaagat tcttcggcaa attcagactc gattttaccg ttttgtcgga atataaaaag 1924441 aaaatgttgt tcctttatct attcggctgt gcacagtaat tgatccgttg tgggcttcca 1924501 cgatattttt aacgatagcc agccctaacc cggttcctgc tctgcccctt gtccgcgctt 1924561 tatctgcctt ataaaaccgc tcaaagataa atggcagatc ttcttccggt atgccagacc 1924621 cggagtcttt gatatcaatt ttcaatccat ccttcacaga atggactgaa atggagacac 1924681 tgccgccggc tgaagtatgc cgcagcgcgt tatcaatcaa attggtaaat acctgctcca 1924741 tcttgtcttc atcaaacata aattcctctt ctgtgagaga aatgtcatga tctaaagcaa 1924801 tatttttttc tttcgcaaca ccggaaaact tccgaatgat cttttctaaa aactcattca 1924861 cattgatttt ttcataatgt aagcctgtat ggcctgattc cattcgggct aaatcaagca 1924921 aatcattaac taaacggccc attcggagcg attcgtcata aatgatttgg gcaatttctt 1924981 tccggtcttc ttcagagctt gcaatgtcat cgacaattgc ttcactgtat ccctgaagca 1925041 tggagatcgg tgttctcagc tcatgactga catttgcgat aaagtcctcc cgcagcttat 1925101 caaggcggcg ttcttctgtc atgtcacgca gtacggcaac cgctcctctg acgtgcgatt 1925161 ccgcataaag cggcgacatc aaaagcaccc atgatctgcc ttgaagcgtc atctcaatca 1925221 tttgttcttt ttcagtgctg acagcgtttt gaaacagctc ttttgcttca ggcggaagat 1925281 tgtcgccttc tttgatattc atgttctgtt cataatacca agcctgaaga aaacgttcag 1925341 ccggcgggtt ggtcacaaga atcgtaccgt caatattaat ggtaataacc ccgtcagcca 1925401 tactgctcaa aatgttagaa agctgctctt tttcttgatt gagcgcattg atatgaaagt 1925461 taagctgccg gcccatttga ttaaaagcgg tcgccagttc accgatttca tcctgagtta 1925521 aaatcgggat ttttgtatcg aacttgccct tcgccaaatc ctgcgcgcct tctctcattt 1925581 ttcggagagg gtacgtgacc ctgcttgata aaaagaatgc gaaaaatgtg gtcagcacaa 1925641 tcgcaattcc agcggcaaga aaaatatagc gggtcgtatg ttttgttgta tctttaacgg 1925701 caagcaaaga ctgggataaa aagaccatgc ctttctttcc gtctttttca tacgggacac 1925761 ctacaatcag gcgttcatta tccgtgtctg tatcgctcag tcccgtccgt ttgcttactt 1925821 ttttatggtc tttgagagct ttatttaagt ctttgtcatg ctgtatttgc tcaaccgtaa 1925881 tagacgacag gcgattttta tcattcggag aataccagtg gttcttctca tcctggatga 1925941 tggcaatgct tgttaagtta tcagcgagtt cccaagtgat tgaccttgcc agtgcctggt 1926001 cctcgtgatt ttctaggatg acagcaactt tattcgcaag ctgtgttaaa tcattctcag 1926061 cttcttccac atggtagttt tcaataaact ccagcaaaag aaccgttaaa atgaacaata 1926121 cgatcaagac gagtgaaagg atcgtaaacc acagcttgcc tactacgctt ttccaaaatt 1926181 tcattcagcg ccgacctcaa atttataacc tacaccccat acggtgacaa tttttttcgc 1926241 agcttccgga gataccttgt tcagcttctc tctcaagcgt ttgacgtgag tgtccactgt 1926301 ccgtaaatca ccaaaaaact catattgcca cacttctttc agaagctttt cccgatcata 1926361 caccttgtca ggcgttttcg ctaagaaata tagaagctca tactcttttg gcgtcaggct 1926421 cacttctgtt ccatcagctg ttacgcggtg agcatcatgg tctattgaca gatgtgaaaa 1926481 cacgagcaca tttttcgtcg gtgtattggc attgaaataa gaggtttggg atgctcttct 1926541 caaaagggcc tttacacgca gcacgacttc tctcgggctg aacggcttaa caatataatc 1926601 atctgttccc gcttcaaacc cctgcacccg gtttgcttct tctccttttg cggtcagcat 1926661 aataatgggt gtcgcttttt tttcacgaat ttgccggcac acttcaattc catcagtccc 1926721 cggcatcatc agatcaagca aaattaagtc ataattggct tcaagccctt tggcaatggc 1926781 ttcatcacca ttttcagctt catctatagc ataattttca cgttcaagat acattcttaa 1926841 aaggcggcga attctggctt cgtcatcaac tactaatatt tttgtttcgt tcgtttggtc 1926901 catgttttcc ccctgctttc cttctgttac tttcatttta tcaaatcgtg agaaagtttg 1926961 agaactgtgt cgctttcaaa ggactatgca taagaatgaa gtccggcaag cacaagattt 1927021 acgaatatta aattaaacat aataatagca aaaccgatta cggccagcca tgctgacttc 1927081 tcaccgtgcc agcctcttga cagtcttaaa tgcaagtaag cggcatagaa caaaaatgtg 1927141 atcagcgccc atacttcctt agggtcccag ccccaaaatc tggtccacgc gagctgagcc 1927201 caaatcattg caaagatcag cgcgccgagt gtaaagatcg gaaatccgat tgatacggcc 1927261 ctgtacccaa cctcatccac cagatcaaga ttgacgtttt tcaccagcgg atgtaataga 1927321 gcgctgattc tttttctgat gatcagacgg agagccccat acaacacaag acctgctcca 1927381 aatgaccaaa tgacagtgtt cacttttctg cctgagaaaa gcgcgggaag atcaacaagc 1927441 ggttccattc ttccttcggt caaaagctct ccctgatgcg gaccgacaag cgcgggcatt 1927501 tcgtacacca tcacgctttt ttctttactt ttgtccaccc agttaaactc cgcttcatag 1927561 cctgcaagac gaaatgccga tgtgattgca ataaaggcga cggttgtgac caggataaac 1927621 ataatcgctt caagccagaa ggtctttttg cttggctttg tctggtctac atgcttcaaa 1927681 agaaagatga caccagcgac aaagctgatg gcaagtatag cttgcccaag cgcggccgtt 1927741 gttacgtgaa tatacagcca gttactttgg agcgaaggaa ttaaaggcga gatatctgtc 1927801 ggaaacatgc tggcgtaggc aatcagcaat aaagcaattg acagcgtaaa caggcctaat 1927861 gaaggcaatc tatagagaaa ataaagaatg ataaacgcca aaacaagcat catgccaaaa 1927921 gcggtggtga attcaaacat attgctgaca ggcgcatggc cgcttgcagc ccaccttgtg 1927981 atgaaatatc ctaggtggca gaaaaaaccg acaatagaaa gggtgattcc aatgttggcc 1928041 catcggtttg gcctgccctt tttatcttta ttcccgcgta tggccccgcc gaagattggg 1928101 acagcgatta aatacacaag aaaggccgca taaagaaaat ttccgctcag ctctgccatg 1928161 acatcactcc cttttcgcct atttctgtgt tttgattaat tctttttggt ccaccggttc 1928221 agtcagtccg gaatcagcca atataaatgc taaatccttc ttcaggccaa accagttttt 1928281 attggtatgc cctgctacca taactgcacc gtcctgtgag tgcagccaaa ttcttcgatg 1928341 ctgccagtac ataccttgaa tgacaccgat cataaaaatg gctccgccga cagcaagcac 1928401 ccagagtgtc agatcctttc tgactgtaag tccagtaatg tttttcgttt cgacatggtc 1928461 aaatttcagc ttgtatttat tattgcctga tccttcgatg gtttcttgga tggcgacaaa 1928521 gctcttttcg cctttcggtt tgtccggcgt tatgatatta aagacaaaag ccggattgtt 1928581 agggatcttt gtttttgtgc tcggctctcc gtcctgatta aaatagaagt caggcaggta 1928641 gctggcgatt tccaccttgt aaccgttacc aagatcatag actgaatctg gatccagaag 1928701 gttgatcttc aggctcccaa aggatttttt tgttttttta tcaatcagct ggaacaccat 1928761 ttggtcaagc tgattctctt tgtaatccac ctggtaaacg gaaaaagaat caaaacgcag 1928821 cggctgattg acacggatgt cttcttctgt tactttttcc agcttcggct tctcgccata 1928881 aacaattttt ccttctctct tgtagagtac ggcatcagtt tgaaagttct ttgccactct 1928941 accgtccccg actctgtcaa tggcatctgc aaataccttt ttttccgttt tgctgttata 1929001 ggtctctacg ctgaattgat tgtttttcaa ataatatttt ccgtctgtac ccggaattgc 1929061 tgcggtttcg ccttctctga cccaaagcgt ctcatcgacg tacatgccag gcacaaatct 1929121 cagcatcgca ccaatcagaa agatgatcaa tccaatgtgg ttgacatacg ggccccagcg 1929181 ggaaaagcgt cctttttcag caagaatgct gccctctttt tctctgattc tataatgttt 1929241 tttctttaat agagtaacta tcttttcttt cgattccccg ttcagtacag taactgtttc 1929301 actgaacaag cgctgccttc ttaaaaaggc cgggctcctt ctgacacctt ggttttttaa 1929361 cgctctatac aacggaatga cccgatcaag gctgcaaatc acgagtgaaa tgccgatcga 1929421 ggcaatgagc agcaaatacc accaagaacc atataaatga tgaaacccga gcaaataata 1929481 aagctggcca aacgtgccgt actgctcctt gtaataagta tcagcctgtg cgcccggagg 1929541 cagataggct tcctggggaa aaatggtgcc gaacgctgat gcggcaaggg ttatgacgat 1929601 aagccatatt cccaccttaa ccgaggaaaa gaaattccaa attttgtcga tgatcgtttt 1929661 gttataggtt tgcgaacgtc ttgcgcttcc gtcatatctc atatcagcga gcggaggttg 1929721 agtttcctga agagctcttc cgcacgattc gcataaaacg gttccgaccg ggtttatatg 1929781 tccgcattca catttgactt gcttcatccc gaagtctctc cgggttttat gagattcata 1929841 taatcgtgta tcatgctttc tgtcatagtg ccggtcacca ccttgacaac ttttccttcc 1929901 ggattgatca aaaaggttgt cggaagcgga gatacgtcat aggcatcaag cacttggcga 1929961 tctgtatcca gaacaaccgg gaaattgact ccgtaggatt tcataaaatt atgtactgct 1930021 atctttgact ccccaacatt tacagcgaca atttcaacac cttggctttt aaaatgctta 1930081 tattggtttg ccatataagg aaactctttt ttgcacggtt cacaccatgt accccagaaa 1930141 ttcaaaaaaa cacctttccc ttttaagtca ctgagctcga tacgtttccc attcgtatcc 1930201 tctaggacaa aattcggtgc gtcggaccct tcggatatac tctctttgcc ggcaaataca 1930261 gcgttgtaaa tggtatagcc gagtgcgcag attaaaacga gaaggatgcc ggtccgaatg 1930321 aataaacgcc tttttttctt cattgtccac tgcccccttc cccctattgc agatccattc 1930381 aattatatca ttgcacgttc atttcacatt tcttactttt tgaaggttat gtgaaattta 1930441 gaaagcgttt ttaccgtgat ccgccagtgc tctgagcctt tttacttcgt gaggcgtaag 1930501 ctctctggca tcgcccgtgt gcaggcctcg caggtttaaa aacgcgtatt cctcacgctt 1930561 cagcttgatt acctcatgtc cgatcgcttc aaacatgcgg cgcacttgtc tgttgcgtcc 1930621 ctcatggatc gtcagctgaa taatgcttgt ctgctttttc ttatccaaag acagcagctt 1930681 cgctttagca ggcgctgttt tgccttcctc cagcctaatt ccgcgctcca gctttctgag 1930741 cagctcttta ggcgggattc ctttcacctt cgccacgtat gttttgtcta tttcatactt 1930801 aggatgcatt agcttattgg cgaattcgcc gtcattggtt aaaagcaaaa gaccgctcgt 1930861 atcatagtcc agacgcccaa tcggataaat gcgctgcgga atatttttaa aaaagtccgt 1930921 caccactttg cgtcctttat catcttgcgc tgcggaaata acgcctcttg gtttatataa 1930981 gagaaagtaa accggctctt cgcgttcaac ctttaacccg tttacctcaa tctgatcaga 1931041 accggtgacc ttaacaccta gctctgttac tactttgcca ttcaccttta cttttccttc 1931101 tttaatcagc tcttctgcct ttctgcgcga cgcaactccg gcatgagcaa tcactttttg 1931161 cagtctttcc atgtctttca cctcaagtat tatcttactt ttttcaacct taacaaacaa 1931221 gctttttcaa attcctatgc caaatctaaa aaaaacgccg ttttcaggcg ctcccaaata 1931281 ataacgtaac gatgatgata gatgcaacta cgccgattaa atctgcaaga agtcccacct 1931341 ttaatgcatc acccattttt ttaatgccga ctgctccgaa atacacagtc agtacgtaaa 1931401 gcgttgtatc tgtagatccc tgcatgacgg aagccagcct gccgataaag gaatcgggcc 1931461 cgtatactgc aattaaatcg gtcgtcattc caagtgcggc cgtaccggag atcgggcgga 1931521 tcagagcaag cggcactact tcagcaggga tgccgatagc ggagaaagcc ggttttaaaa 1931581 gatccattat aaaatcaagc gcgcctgatg atctgaaaac agttatagcg acaagcattc 1931641 cgactaaata ggggataatg gaaaaggcaa tttctatccc ctctttcccg ccttcgacaa 1931701 acgattcata tgtcggaacc tttttgatcg ttccataaag aagaattccg gcaataatga 1931761 ttggaatcat ggctaaagac agccagttga tgatttccat ccgctcacct tcccttcttt 1931821 ttgcggcggt aataaaaata ccgatcaatg ataatggcac cgattccgga aataagcgtt 1931881 gccaaaatgc ttggcccgac gatatctgtc ggcgttttgg aggaataagc cattcggaca 1931941 gcgatcaccg ttgtcgggat gagtgtgatg caggacgtat taacagctaa aaaagtaatc 1932001 atcgaccggc ttgcttccga tcggtttccg ttcagctttt tcatttgttc cattgcttta 1932061 atgccaagcg gagttgctgc atttccgagg ccgaagaaat tcgccataag attagataaa 1932121 atatagccca tcgccgggtg atccggcggt atatcaggga acagtttaga tataaaaggt 1932181 ctgcacatcc ggctgaaaat atccaaaagc cctgactgct cggcgatttt cattaagcca 1932241 agccagaaaa caagcacgct catcaatcca aatgagatcg taatcgcttc tttcgcaccc 1932301 ttaaacacgg cttcatttac atcttgcaga gttccgttgc acatcgcaaa aacgagtccg 1932361 atcacggtta aactgaccca aattatattg accattttgc tccgcctgcc gcattcagaa 1932421 agattgattt aaacgtttca aaaaattgtt tcttcggttt ttgatgccgc tcattttcat 1932481 aatagatcgg cacttttgcg atggttgcat cgttgaacat gatctccatg tgccctacga 1932541 tgtcagggat tttcgaggca tctttttccc atgctttttt cggcttgagc agtgtggtat 1932601 taatttttac attttctttt tcctcttcgg tcagcaaata ggtgatatca cgtttgataa 1932661 aagccttcga ttcataaaat gtgcctttca gctttggaat atcccctttt tttgcaatta 1932721 aataggtttg ataatgctca aacacatagt taaacatctt catatggtca tcccaatcat 1932781 tagggtcatt aatggtgacg gctatcaggt caatgccgtc ctttgaagcc gtagagacca 1932841 gtgtccgttt tgcaagtttt gtatagcctg tttttcctcc tgtgctgtac ggataaagca 1932901 tggtcagcag tttgtttttg tttttccata cgctttccat cgtttccgct ttgtatattt 1932961 ttgtgcctga aatcttttga tagtctttca gcttcatagc atacttagtt aaaatggcca 1933021 tgtcataggc tgttgaataa tgattttcat ggtcgtccaa tccgtgcggg ttttgaaaac 1933081 gggtgttttt cataccaagc tgctcggctt tttgattcat catataaaca aacccatcga 1933141 ggctcccacc gacatgctca gcaatcgcga cagcggcatc gtttcctgat cttagcatca 1933201 ggccatacac aagatctttc agcttcactt tttgaccttc tgttaaataa atggcggagc 1933261 cttctgttct gacagcattt gccgaaaccg tcactgtttg atccattttg ccggattcga 1933321 tggcgaggac ggcggtcata atttttgtga tgctcgcgat ccgccttttt tgatgctcat 1933381 ccttggcata taacactctg cctgacgcac cgtcaataat gatcgcgctt tttgcactga 1933441 catctatagc agcatgtgct gtattcacat ttacggttgc aataagaaaa gaaatcatga 1933501 tcacgaatac tgcttttttg aaaatgcgca tgtttgctca cgtccttgtg gtggtttgta 1933561 caagtttatg cgcatgtcca tcagttatga ataacaatta tatttctgga agcaaacata 1933621 aaaaaactct ccctgaaaaa gggagagtaa acgttatctg attggcgcca tgcttgatcc 1933681 ggacgcttcg taatgagcca gctcttccct catcttcaga aaggccgcgc tcaacggcaa 1933741 taataattgc tcaagcgacg caggaacagc atgataaaac tcaattgcgc tgaccccggt 1933801 ataagacgcc cggctatttt cacaccacgt gtcttttttc ggcataaaga actcttcaat 1933861 gcattggtga tacacattat aaagtgtttt ttccgctctg gcttcctgaa aaggctcctg 1933921 catcaggaga cgacggcacg cttctgcgcc tccttcacaa aatactgcca ttcttctcag 1933981 agtgctaagc acatcacagc agtatccttt ttcaataggc aattcagcct gtaaggactc 1934041 aagcgtcgtt tgatttaggt aatcgttcac ggtattgaca accattgata agaattcgcc 1934101 tgttttttga gtctgcgctc gcacaatcga atgtcccatt tcgtttggta tcttcccctc 1934161 atgtatttgt ctctcacatt ttgcttcttt catgatagct tcttccttat atcttatgat 1934221 gatgaaaaag cgcgattcat taaacttcta ttttatatct tcgaaggttt ggttaaagtt 1934281 ttcaaaaaat aaatctgctt cttcttgaag aacgtcttct tccgcatttt caggcagcgg 1934341 cggaagctcg tccagcgttt tcagaccgaa ttgttcaaga aaagtcggcg tagtaccgta 1934401 taaaatggcc cgccccggac catcggcacg ccctacttca cacaatagcg ccttcgcgac 1934461 aagactgtgt aaaatccgct ctgattttac tcctctgatt tcttcaattt ctgctctcgt 1934521 aattggctgt ttgtatgaaa caatggccag tacttctaaa gatgcttgag aaaggccctt 1934581 tgacggcact tcaatcagtt ttttcaagta aggcgcaaag tcttttttgg tagagagcat 1934641 gtacgtatct gcatactcaa taagttcaat ccctcgtgta tctccgcggt attcgtccgc 1934701 cacatccgcc atgatcgtgt tcagttcagg ctcttcgatt tcaagcactg ttaacagctg 1934761 cttttttgta agcccttcat cgcctgccgc ataaagaagg gcttccacaa tagctttcca 1934821 attcacgata tcaagcccca tgaatggatt cactccccgt aatgtaaata tctgaaaaat 1934881 tgtgctcctg ttcaatgagg accagctgat ttttcatcag ctcaagaaca gctagaaagg 1934941 tcactactaa atgttctttt tgctcatatg gaaacagatc cataaagtta attctcgttc 1935001 ctctagattt caagctgtgc acgatttcgt tcattctggc ttcgattggt atgtcctgtc 1935061 ttgtaattgt tgtttccatc ggcctgttta tttttttgcg tttcagcact ttttgaaaag 1935121 ctccgatcat atcatagacc gtgacagaga gcttttgctc agactgtttt acttcttttg 1935181 catattcact caaatcactc ggcggtttcg tgaacgattt ttgtctttct tcttcccgtt 1935241 cttttaaatc cttcgccgca tctttatatt ttcggtactc aatcagcttt tcaatcagtt 1935301 cctcccgcgg atcttcttct tcaagtaatt catcttcaaa aagctcctcc tcttgcttcg 1935361 ggagcagcat tctgctttta atgctgagca gcgtggcagc cataaccaaa tactcgctgg 1935421 caatgtcgag ctcaagcacg cgcatcgtat gtacatataa taaatattgt tcagtgatct 1935481 tcgccacagg tatatcatat atgtcaattt caagacgatt gattaaatga agcagcaggt 1935541 ccaatgggcc ctcaaacgta tcaattttca cttgatattc ttccatcatc tcaccatttt 1935601 caagtatcac tctcattgcc ggaaaaactg gctaccctat agtataagcc accaaaaagc 1935661 tctcgtccaa tactatttca tatcctgttt tgaaggagtt tgtacagaat attcaaaaca 1935721 caagaggtgt ttgctcggag cgcagaagcg ggagaaaaag cctttgcttc tggttttcct 1935781 ttctaagaag cactagaggc cgggcgttct tttttccttt tatcccttct atggtacact 1935841 aaaagcacat taaaggagga agcaccttgt atccgaaagc ttatatagat tatctcgttg 1935901 agtttcatgc gacacgggat tattttgaat gccatgaaat attagaagaa tattggaagg 1935961 aagatccgcc aaagaaacga aaacgctatt gggtgggctt tattcagctt gcagtggctt 1936021 tatatcatca cagaaggcag aatacagccg gggcaaaaag actgatggcg aacagcatcc 1936081 ggattcttca agcagaacac cgggcagtcg aagacttagg gcttgatcat ggccgtttgc 1936141 tcgaacttat gcaatcggtt tacgaacaaa tcgaaaccgt ctctgcctat aaaagcatta 1936201 tactgccaat caaagatgag aaactggagg aagcatgcag gatcgaatgc aggaaaaaaa 1936261 agtatacatg ggggcagccc agtgcactca gcaacatatt tcttatcgac aaacaccgtt 1936321 tgcgggatcg gactgacgtc atccgtgaac gtgaaaaaga aatagaacgc agaaaaaaaa 1936381 gcagagactg atcacagcct ctgcttaatt attgtatgaa atgtcttgat cctgctgacc 1936441 ttgacaacgt tcgaaaaagc tctgcgttaa ttcatttgga accagtactt gcgttttgaa 1936501 taaatgcttt aaagcatcca tcatctgttt tccgattcct tgatggcgat gagaaggatt 1936561 cacactgata tgccggatct caacctcaga atcctttttt tcgactccga ttgctccgac 1936621 gatatcctcg tcctctttcc aaagaaagag ctggcggtct gtatccgttt cgtagtcctt 1936681 aattgtctgc tgaagctgct taaggtcttt ttcattcggc ataaacgaaa gaagccccat 1936741 cgcaatcttt tcaaacgatt ttttataacg aattaacata aaaacccctc tatatccaaa 1936801 atgtccagtc tgctattaac ggatacgaat aggtgatccg ttttctcaca ttatatcatt 1936861 ttcgccatat ttttaaactg ttttcagcaa attattcaaa tgagcggttt aaatttgcca 1936921 tttcaatggc agaaacagca caatctacac ctttgttgcc cgcttttgtg ccggcacgct 1936981 cgatagcctg ttcgatgttt tcagttgtta caattccaaa gatgacaggt acaccagtag 1937041 tgtttgctgc ttgcgcgatg ccttttgcag cttcattgca gacataatcg taatgtgtcg 1937101 ttgcgcctct gatgacagtg cccaatgtga taatagcatc atattttttt gtttccgcca 1937161 tttttttcgc agcaaacggt atttcaaatg cgcctggaac ccaagccaca tcaatgtcat 1937221 ttgtgtctac gccatgtctg agcagcgcat cttctgctcc gctcagcagc ttgctcgtaa 1937281 taaaatcatt aaatcttcct actacgattc cgattttaag acctgtacca actaaatttc 1937341 cttgtatgat attcatatga ttcccatcct tttttgtgat atttgtgatt agaaatgaag 1937401 taaatgacct agcttgttca ttttggtttg caaatatttt ttattgtgtt ctttcgcctc 1937461 catttgaagc ggcactcttt ctgaaatact gagtccgtag ccttcaaggc ctgcgatttt 1937521 tcgcggatta ttcgtcaaaa gcttcatatt ccggacaccg aggtcgcgta aaatttgtgc 1937581 tccgatgcca tagttgcgaa gatccggcaa gaatccaagc gcctcattgg cttctacggt 1937641 gtcatagcct tgttcctgaa gcttataagc ttttaattta ttgattaaac cgatgcctcg 1937701 tccttcttgg cgcaagtaca ggagcactcc acggccttct gcggcaattt ggttcagcgc 1937761 ggcgtgcagc tgcggtccgc aatcacagcg atgagagcca aacacgtcac ctgtgagaca 1937821 ttctgaatgc acccggacca ataccggttc ttctccgaac ggcacatctc ccatcacaaa 1937881 tgcgacatgc tcttttccat ctacctcatt tgtgtatcca taaaccttaa atgtcccaaa 1937941 atcagtaggc agcgtaatgt caacttcacg ctcgacaagt gttgtcagat tgtaacggta 1938001 ttgaatcaaa tccttaatgg tgatcatttt taattgatgc tttttcgcaa tttcaatgag 1938061 ctcaggcact ctcgccatcg ttccgtcttc attcataatt tcacaaatga cgccggctcc 1938121 tggagatccg caagcttcag caagatcaac agcagcttct gtatggcccg ctcttttcag 1938181 gacacctcct tttttcgcaa tcagtggaaa aatgtgcccc ggacgctgaa aatcagatgg 1938241 cacggatttg ctgtccagca atgcttgaac ggtaaaagat ctttcttgag cgctgatacc 1938301 tgtcttcgtt tcacgatggt ctatgcttac ggtaaatgca gtgtggtgag agtctgtatt 1938361 atgctcaacc atagggtgaa gatcaagcct gtctgcgatt tcctcactga gcggcgtgca 1938421 gatcagtcct ctcccatgtg tcgccataaa gttaatgact tccggcgttg catgctcggc 1938481 aagagccaca aagtctcctt cattttctct gtcttcatca tctacaacga tgatgacttc 1938541 gccttttttt aaagcgtcca gtgcttcttc tatcggatga aacatgcaaa tcttcctctc 1938601 taaaagccgt tttcgcttaa gaaggctttt gtaatggttt gttgggtctt attttcattg 1938661 gctttatgca aaaatcgata catatatttt ccgatcatat cgcattcgat attcacttta 1938721 gagccgatcg ttttttctga aaagatcgtt tcgctgatcg tatgcggtat taaggagatc 1938781 gtcactgtgt cttctgtcag gccgaatatg gttaagctca cgccatccac agtaattgat 1938841 ccctttaaaa ccaatgtttt tgttaatgac gggtccattt ttaaatcata gtaaactgcg 1938901 ttgcttttct cttcaattcg tgtgatttcc gcagttccgt cgacatggcc tgagacgaaa 1938961 tggcctccga aacggccgtt tgccgccatc gctctttcca gatttacttt gcttcctttt 1939021 gttaaatcat tcagtgacgt agctttgact gtttcaggca taacatccac tgtgaattga 1939081 ttttttgtaa aatcagtgac agtcagacaa atgccgttca ctgcaatgct gtcgccaaga 1939141 tgaacatcct ctaaaatctt tgagcattta atagttaagg ccattgcatg ccctgctttt 1939201 ttcatggatt cgattgtgcc tgtttcttcg ataattcctg taaacatggt caccatccta 1939261 ttcctttgtc ggttttgccg tcagtttgat atcacggccg atttgggtta tatcagtgaa 1939321 ttgtaataag gggacatctt tcattgattg aaaaccttca ccggagatta agctgggagc 1939381 atgcgttcct ccgattagtt taggggcaaa atagaagatg atttcttgaa aacagccttc 1939441 tttgacaaag cttccgtgaa cagctgaacc gccttccaca tacaccgaca tgatgccttc 1939501 ttccgctagg atcttcaaaa catcaggaat ttgaatgcgc tcggtttcaa gtgtaaatat 1939561 gttcactccg aaagctgaaa gccgtttttt cttttcctcg tctgcgcgtg ccgtcgtaaa 1939621 aatccatgtc ggcgctattt gatcgcaaat cactttagcg tcctcaggaa tcgagagtac 1939681 ggtatcaagt atgacccgaa ccggctgttt tgttacattc ggcagtctgc aggttaagct 1939741 cggattgtcg gctttcactg tgccaactcc gactaaaatg ctttggtgtg ttttcctgta 1939801 ttgctgagca tcctgtcttg cagcctctga cgtgatccat ttgctgtcac ccgtgctggt 1939861 agctatcttg ccgtcaaggc tggcagccgc ttttagcgtg acgtacggaa ggcctgtcct 1939921 cataaagtgc agaaattttt cattcagcct ctccgcctgg tctgccagga tgccttccct 1939981 tacctcaatg ccagcttctt tcatcatgct gatccctctt ccagccacaa gcggattagg 1940041 atctctcatc gccacgaaca ctcttttgat accagagttg ataatcaatt ctgcacatgg 1940101 cggtgttttt ccgtaatggc tgcacggttc gagtgtaacg taaatgtcgg caccctctgc 1940161 atgtgctcca gccatatgga tggcatgaac ttctgcatga gcttcaccat attttaaatg 1940221 ggcgcccatt ccgacaattt gtccgtcctt tacgacaaca gcgccgacga gcggattgga 1940281 ttcggtctgt ccttcgccct gcttcgcaag atctaaggcc agcttcatat aatactcttc 1940341 catttgtttc cctcccctct tttgttattt accgtcaaaa aagccccgaa tttataaaaa 1940401 attcggggct ttaggtattt tacgcaatag gaaataacac tatgcatttt taaacatttt 1940461 gcatagcggc tcatcatcct tctcccatcc agactttcac tgtcggcttc agcttaaact 1940521 gaatccaccg cgtgcttatg cacacgggtc acgggctcta aagcaaatgt gctttactac 1940581 cgccggtcgg gatttccacc ctgccccgaa ggatacaatc tttattcatt tgtccttatt 1940641 ggttattata gcgatccttt ttaaagtacg caatgaaata aacttacaat ttgagaaaaa 1940701 caaaacatca cccttcgatc cgaaaggtga tgttttttaa tcattcactt ttgcaacctt 1940761 gattaatccg tcgatccgct ttgatttgct gaagtaagcc ttaatcttgt caccttcttt 1940821 tatatcagat aaatcctgat ttaatttttt tccgttgaag atgattttcg ttccgttttc 1940881 tgctactcca tgatactctg agccgtcaat tttcgtcact ttatattcct ggatggtgta 1940941 ttcctcttct tccgaggaca aggtttgtcc aattgctgtc ggaacatcct tcagctcaat 1941001 atcatttatg tacatataac cgcctgcaag taaaagcaaa agcactaaca gaatggtaat 1941061 cttggttttt attcttccca tttctaaacc tccagccaat atgaatctat tcattcatat 1941121 gagttattcc tttttttcat gaataaaaaa ccgtaaattc tcgtaaatta ttaatataac 1941181 gatgcataac gggaatatgt ttcacatttc tgcaaaaatt tcttttctat agatatacga 1941241 atttatgttc tgtttttagg ggatgaccgt aaaaaagata taaaaaaagc agccccaatg 1941301 ggaagctgct tgatcctaat ttgttttgcg catttcgtta aacgggtaga aaacaaactt 1941361 tgacgtaccc gcaatttgtt ttttcgtgaa gaggccaagg ccgttacggc tgtccatgga 1941421 attgcgacga ttgtcaccca tcacaaaata cttgttatca ggcactttaa ccgggccgaa 1941481 atcatcggtc aaatggtcaa aaccgtcctg tttcgctctc tttttattag ccgccaaata 1941541 aggttcgtcc acctttttcc cgttgatata gagctggtca tttttcatct caaccgtatc 1941601 gccgggaagg ccgataatac gtttgacata gtgaacatca tctccgttta acacgacgat 1941661 gtctcctcta tcaaactcgc cgatgtattt gactgtcata ttaacaaaaa ccctttcacg 1941721 gttgtgaagt gtaggataca tagagtcacc atcaacgaca tacggcgcaa aaataaagtt 1941781 gcggatgagc aaagcaagaa cgacagcaat cacaattgct tttgcccatt ctaatattga 1941841 ctttttcttc gaaacatttt ctgatttcaa ctgatttcct ccaataaaca acggtcttca 1941901 atttatgtta tcacgaatcg aaaaaaaatc ccattaggac cattgaagtg attttacaaa 1941961 ctgttaatct tcatcttcta cccacatcat gcctattttt tcttgtcgat cataactagg 1942021 cctgaaaata ttgaaagaaa tgaatcgcat aattcagaag cgatggactc agaagaaaga 1942081 gagttctcat atgcaaaatc tttagatcgt atataaagca tgaggttacg ggcagtttgt 1942141 tcatttactg cattccattg atctcccagt ccatgatacc catggcactt gacaaaacaa 1942201 ttaacgtcat gaaggttact ggaatgtttg cggcaaccta tttcacaggt gataaccgca 1942261 ccccgttttt tgctttcata atatgtttaa aatcattcaa gctcgaaaac atggatcagc 1942321 ctccaaaaaa taaatccaat atattcccgg cagttgaaga ctctttatta taaaactctg 1942381 aatatccgca gttcttacag taaaccacta gaaatcggtt atgctgcacg tcaaacagct 1942441 ttgataatcc cgtgccggtt gtagctattt ctttttgtcc ggcttcagta ctaccgcatt 1942501 ttatacagcc tttgttgttc atatcgcgat ctccttttca ttacatcacg tttgtttgat 1942561 ttattttact acaaaatatc aatcccaatg acccgtacta ctttaaagtt tacttaattt 1942621 tgattacata ctaattgggt tcgtttctca gcttggtaaa tcttctggag aaacggaaaa 1942681 gctccatgac caaaacattc aaactcagcc aaacaccgcc gaaggcgtaa cccgcagcaa 1942741 catcactcgg atactgctca taaagtacac acggctcagc ccgatgagga ataaaacgat 1942801 aataaacaaa aaaatgcaac agtttgcaga cgcgtcttgt gagaatgacg aacaaaaaga 1942861 taagcacaaa aaccaaaaat gacaaatgcc gttaaagtct gttcgctcgg gaatggatat 1942921 aatacatgac tttccaaagg agcgtgaaca ggatgaaggg aatgaaagag ccgtctgatt 1942981 ccctcttcat aaagctcccc accaatgact aggaaaaata agaaagagag ttcgattttc 1943041 cgatcttgcc ctctgaatac cgtccaaaaa aaagttagaa caataacggc taacagaaca 1943101 cctctcgacg caaaagcttt ctgaattgca gctgggccca gtctataccc gatccaatac 1943161 gacatgctca ctcccacagc tccccaatcc ggccgctaac atgcttagca cccagtttaa 1943221 cttttcttga aacacgagaa caccggcaaa ctctcccggt ccaagtaaag ctagaagctc 1943281 taacatcaag acaataaaca agacggcata tccgtactgt tcgagcaacc ccgtcaaaac 1943341 ttgcatgtga ttctccttaa acttttttgt tcttttatca ttcccaatcc actttttgta 1943401 taatcagcac aattttatct tcagtcgtcc aacaacattg tctatggcgg gatcttctct 1943461 catacattct tttttgacat aggaggagca atagcatgaa atgggaggaa acaaaagata 1943521 cgcagggagt ttgccaaaat tttgggcagt tcgttctgcc accgagtcag gtgtttgttt 1943581 gcccacctca tcccttgtca attccccatt tttcccgttt gaggttcgaa atggtaaagt 1943641 atttcactta gtttcttaca tgaagaggta aattctttgc tcaccgaact aggatagcgg 1943701 cgtatggcga tttctacatt gcataaccac tggttattta gtgagccgtg agcaatgtat 1943761 atgcactttg agtcagcaca ggatgatcct attacattcg ccagaaaagc agctgccgca 1943821 ttcagagtag ttaaaagaat agacagatat ctgggcttcc ggaagcttta aaggaggctc 1943881 ttttttcgag catttttata aatcaataaa aacaggcatc tcctaaatat ttttgccgat 1943941 aagtttacgc taatcaactc tagcactaat acatataaaa aatagaatga tatgaaagga 1944001 gacttgatag tatgattgat tatcctatta atataaacaa cgtttccggg aacagtgtaa 1944061 ttaacgtagg cggcgctttt atgatcaggc ctttaacttt gtccaaatct gtgtttggct 1944121 ccggaggttt aaacacagga attgtctttg aaaataactt tgtaagcaaa gctaaaatga 1944181 ttaatcatca atttactgat caaaacgtca ccaaaacttt ttaatgtatt caatacacgg 1944241 gggtcactaa ctaaacacct ggttttgcca accgccatca gcattcggcg gttttttatt 1944301 gaacattttt ggccaataaa aaaagcttcc tctctaagag gaagcctttt gcctgccgat 1944361 tagccttcta cacgaacttc tttcatgaca tcgccattag acatgttttt cgcgaattct 1944421 aatccgcttg ttactttacc aaatacagtg tgaacaccgt tcaaatgagg ctgtggctca 1944481 tgaacgatga aaaattggct gccgccagtg tcttttccgg catgtgccat agaaagtgcg 1944541 cccgcctcat gtgtatgcgg gttgccttct gtttcacatt tgattgtgta tcccggaccg 1944601 cctgtaccag ttccgtgcgg gcatccgcct tggctgacga agccagggat cactcggtgg 1944661 aatgtaagcc cgtcataaaa gccttcgttc gcaagctttt caaagtttgc aacagttcca 1944721 ggtgcagctt caggataaag ttcaaattca attttgttcc cgtcttctaa taaaaagtaa 1944781 cctgttttca attgtatgcc tactttcttt attttaattt tcaaaggaga ttatgtatag 1944841 gttatagcct gtctctcctt gtcgcggcta ttataccaca cctttcgggg gaaaacgaat 1944901 ctcccgagct ttactaaaaa ataaaaatga aacctgaatc tctttatctc cgtctaacct 1944961 aacggaactg tatttttcat gattcaggtc ctcacaaagc agcactatcc agctgcttgt 1945021 gaaattgaag gaggtcaaac tgctttgaag aaaatttgga ttggaatgct ggcagcggcc 1945081 gttttgctgc tgatggttcc gaaggtcagt ctcgcggatg ccgcagttgg agatgtcatt 1945141 gtaacactgg gtgctgattt gtcagaatct gacaaacaaa aagtgcttga tgaaatgaat 1945201 gtccctgata atgccacaac ggtaaccgtg accaataagg aagaacatga atatttagga 1945261 aaatatatat cgaacgcgca aatcggatcg agagcgattt cttcatcgtc aatcaccatt 1945321 gccaaaaaag gctccggatt gaatgttgag acccataata tcagcggcat cacagatgaa 1945381 atgtacctga atgcactgat gacagccggt gttaaagatg cgaaggtgta tgttacagca 1945441 ccgtttgaag tatccgggac tgccgcttta actggattga ttaaggcgta tgaagtttct 1945501 tctgacgaag cgatctcgga ggatgttaag caggtcgcca accaagagct tgtcacgaca 1945561 tcagagcttg gagacaaaat cggtaacgaa aatgcggcag ccctgattgc aaaaatcaaa 1945621 gaagagtttg ctaaaaacgg ggtgcctgat aataaagctg acatcgaaaa acaagtggat 1945681 gacgcagctt ctgatttaaa cgtcacactt acagacagcc aaaagaatca gcttgtctcc 1945741 ctattcaata agatgaaaaa cgctgacatt gactggggac aggtcagtga ccagctagat 1945801 aaagcgaaag ataagattac gaaattcata gaatcagatg aaggcaaaaa cttcatccag 1945861 aaagtcattg atttcttcgt atctatctgg aatgcgattg tatctatatt caaataagaa 1945921 aagcgccgaa aaatcggcgc tttcttttat tgctttacac ccgttttaaa tggcagatca 1945981 agttttacaa tatcttcgta tgtttctcgc ttcacgacta aatgagcctc accgttttcg 1946041 acaaatacaa cggcgggtct cggaatacgg ttataattgt tggccatgct gtatccataa 1946101 gcgcctgtac aaaaaacggc aagaagatcg ccttctttta cttccggcag gtcaatatcc 1946161 caaatcagca tatctccgct ttcacagcac tttccggcaa ttgataccgt tttgtcatgc 1946221 gcttctccga tcctgttggc tgccgcagct tcatatttag cttggtaaag cgcaggacga 1946281 atattgtcgt tcatgcctcc gtctacagcc acatattggc ggacacccgg cacttctttt 1946341 tgagagccaa ccgtataaag agttgtgcct gcgtctccca cgagagaacg gcccggttcg 1946401 atccaaattt ccggaatgtc aaaaccgtaa cgggaagcat tttctttcac agcttcgata 1946461 attttttcaa cgtattcagt ggcatgaagc ggttcatcat cttccgtata acgaatgccg 1946521 aaacctcctc caagattcag caccttggat acaaatgaat atgaatctct ccattcgtct 1946581 agttttttga agattttttc cgctgctaac acaaaaccgg ccgtatcaaa gatttgcgag 1946641 ccgatatggc aatggacacc cagcagctga atgtgttccg attgtaatac ttgttcaatg 1946701 gcccgttcag tttgtccgtt atgaagatcg aaaccaaact ttgaatcttc ctggcccgtt 1946761 gtaatgtagt catgcgtatg cgcttctact ccgggcgtga tccgaagaag aacatcgatg 1946821 gagtgacccg tttctttaca taggtcttca agaagcgcga tttcatagaa attatccacc 1946881 acaatgcagc cgatgcggtg ctcaagcgcc atccgcagtt cttccctgct cttattgttt 1946941 ccatgaaagt ggatgcgttc tgccggaaag cctgctgcaa cagccgtata tagctctcct 1947001 ccggatacga catctaaaga aagtccctct tcctcagcga gctgaatcat tgcgactgat 1947061 gagaatgctt tgctcgcata tgccacctgt gctttcagcc ctgcagaaat aaacgcctgc 1947121 ttaaagcttt tagcacgctc acgtattaaa gccacatcat atacgtaaag aggtgtacca 1947181 tatttctccg ctaaatagag agcatccaca cctccgattt ctaaatgacc atgttgattt 1947241 tgtctgcttg tgccgtgtaa gaacaatgtc attccctctt tctccgctta tggatgaaag 1947301 gacagtttta tggactgtcc cttcataatt aagacataca ttatcatact cttcagtcag 1947361 tttcaatgcg attatgaatt ggtaggctgc cttaagcgat ttttggggtg aacgatgctg 1947421 ggtcttactt ttgcgccagg tttcgctgtg cggacaagaa cctgccacag cgcctttccg 1947481 ttaaagggaa tcagcggcca taagtacggt gtctgaaggg atttgatgct tgccatggca 1947541 ataattagca ctgtaaatcc gatgacgagc ccttttatat gaaataaagc aacgagtatc 1947601 atgaggacaa gacggctcat tttgtttgcc aagcttaatt cataactagg cgtcgtaaag 1947661 gttccaatcg ccgcaagtga gacgtacaga atcacctcag gagaaaaaag gccgacctca 1947721 atcgcaatct gcccgatcag aacagcggca attaaaccca ttgctgtcga taaagccgtc 1947781 ggtgtgtgaa tggcagccat tctgagaaac tcgattccta agtcagctaa aaatatctgc 1947841 aggatgatcg ggatatgcgt atctttattt aaaccgataa atttcatgtt gtccgggagc 1947901 agatcaggct gaagcacaaa gagaaaccag atcggaagaa ataaagtaga agcaagaata 1947961 ccgaaaaatc ttacccgagc tcgtggtcat tcggcataat tacttaaatt ttgtccagtc 1948021 tcccatcgtc cgctttaaga atgtgataaa cccggctttc ttcatatctt cttttgcagc 1948081 aacaggactt tcagcgagta cttctccatc ctttttcaga acaagagtgc caagctcttg 1948141 gcctttttga atcggagcac taatattgtc cttcatcttg atttcttttt tcacatcgtt 1948201 catatcctcg ccttttttcg tcaatattga aatcggctca gatgtagtga gttcgataaa 1948261 tttttgtttc ccttttttga cctttacttt tgctactgtt tgatttcgtt tatataaagg 1948321 atgcgtttca tattggctaa aggcgaagtc aagcattttt gtcacttgcg cgtttctttc 1948381 tttaggcgtg ctcgctccga atacaaccgc tatggcccgc atgtttcctt ttttagccga 1948441 agcagtcaga caatatttcg cttcgcctgt atagcctgtt tttacgccgt ctacaccagg 1948501 ataaaatttg ataaggcgat ttgtatttac aagccaaaac tttttatctg tattttcacg 1948561 cagataatct tcatacgtgc cggtaaactt cgtaattgat tcgtatttca ataattcctt 1948621 agccatgatt gccatgtcat aagcagagct gtagtgtcct tcctcggtca gtcctgttgg 1948681 gtttttaaag gatgtatttt tcaatcccag ctcttttgct tttttattca ttttcttcac 1948741 aaattcttct tcagagccgg aaataaattc agccatggcg acggaagcgt catttcccga 1948801 agcgattgcg atgcctttca gcatttcttt gacagtcatt tcttcgccgg gctcaaggaa 1948861 tatctgtgag ccgcccattg acgccgcatg ctcgcttgta cggaccttat cactcatttt 1948921 gattttgcct ttatctaaag cttccataat caaaagcatc gtcataattt tcgtcatgct 1948981 tgcaggcgcc agtctctcat tgctgttctt gttgtaaagc acttttcccg tgtcacgttc 1949041 tatcagcacc gcagacttcg cttcatgagc aagctccgat gtacgttttc cgtcttgttt 1949101 tgcaaatgca gacggtgcaa atgtaagcag cattatacca atcaacaaag tggataaaag 1949161 acgtttcatc tcaaaagccc tccatttcat aatccttttt attttttcca agcgtgatgg 1949221 ttttatacgc cactgatgga aaatgtttcg aattttgggc ataaaaaaag acagctgtgt 1949281 gatatcagac acagctgtct tttggtcctg cattgattca tatttattcg tactgagcga 1949341 cgatcgcttt aacaagcttt aagaatccag cttttacttt ttcggtcact tccataactt 1949401 catcgtgact taaaggctga tccagaattc cggctgccgc gttagagatg caggaaatgc 1949461 caagaacccg cattcccgca tgattcgcta caatgacttc cggaacagta gacatgccga 1949521 ctgcatcaga gcccatcgtt cttaagaaac ggacttctgc cggtgtttcg taagaaggtc 1949581 ctgtcacagc agtgtacacg cctttttgaa ttgggatatt aaggtctttc gcaatctttt 1949641 cagccaggct ggacagatct ttgtcatagg ctgaagacat atctggaaat ctggcgccga 1949701 aatctgcttc gtttggcccg attaacgggt ttgttcccat aaagttgata tgatcggtaa 1949761 taatcattaa atctcccgca cggaattcag tgttgacacc gcctgcggca tttgtcacga 1949821 tcaacgcttc cacaccgagc gctttcatca cgcgtacagg gaatgtgact ttctccattg 1949881 agtagccttc ataaaaatga aagcggccct gcattgcaat gacggaaact ccttcaagag 1949941 tgccaagcac aagctgtccg gcatgccctt caacagtaga taccgggaat tcaggtatat 1950001 cttcatattt cagcttgacc ggattttcga tttcgtccgc caaaatgcca agacctgagc 1950061 ctaaaataag gccgatcttt ggagattccg gcaggttttg tttaataaaa gcggctgcgc 1950121 gttcaattct gtccttcaag aaacagtccc cctattgtaa taaagataaa aagcttttcc 1950181 cgtatttcgg tttatttgtt tggaaattat cagcgatcgt tgcgccaata tcggcaaatg 1950241 tatctgcaag cggcagcatt tgcgctttct tatgtttttt gctgtaagcg agaatcggca 1950301 catactcgcg tgtatggtca gtcccatgat gaatcggatc attgccgtgg tcggctgtaa 1950361 taattaacag atcgtcttct ctcatttttt caaacacttc cggaagccgc gcatcaaatt 1950421 cttcaagcgc gcgtccgtag ccttcagggt cacggcggtg tccgaataac gcgtcaaaat 1950481 caacaaggtt cgcaaagctc agacccgtaa aatcttctcc cagcgtatcg atcaccttgt 1950541 ccattccgtc catattagaa accgttctgc gtgaagaagt aatgccttct ccgtcgtaaa 1950601 tatcagagat tttaccgatt gaaatcacat ctaagccgca gtctttcaat tcattcatga 1950661 cagtgcggtc aaacggcttc agcgcataat catggcggtt tggcgtccgt ttgaattgac 1950721 ccggctctcc gacgaacggc cgtgcaataa tgcggccaac catatatttc ggatcaagcg 1950781 tcagctctct cgccgtttcg caaatgcgat acagctcctc aagcggcaca acctcttcgt 1950841 gagcggcaat ttgcagaaca gagtcagcag acgtgtaaac aattaaagcc cctgtctcca 1950901 tgtgctcctg gccaagctca tccaaaatcg ctgtgccgga agccggcttg tttccaataa 1950961 ttttgcggcc agatctcttt tccagctctt gaagcaattc atcaggaaag ccttccggga 1951021 acactttaaa cggtttatca atgtataaac ccataatctc ccaatggccg gtcatcgtat 1951081 ctttgccgtt tgacgcttct tgcatttttc cataataggc aagcggatgt tctgtttttt 1951141 ctacaccttt gatatcttcg ataagaccaa ggccgagctt tgccatattc ggcatatgta 1951201 atccgttcat atgctcggca atatgaccga gcgtatgagc gccttcgtca ttaaagtcag 1951261 cggcatccgg cgcttcgccg attccgactg agtccatcac aattaaaaac acacgattat 1951321 atttgtatgc aggcatcttg aaagcctcct ttttttctat acgtctattg tatcgctaag 1951381 aggtctgaca actcaagtat aaaccgtttt cattcccgtt gacaatgtat ttggaaataa 1951441 tgagaaactt caatattttc tgtcgctcta aacaaaaaag ccgcagccac ctgcggctat 1951501 gctcgcggat gaaactgctt gtacacatcc ttcagccttg ttttcgtcac atgcgtataa 1951561 atttgcgtcg tggatatatc cgcatgaccg agcatttcct gcaccgctct taaatctgcc 1951621 ccgttctcaa gcagatgcgt cgcaaaggaa tgcctgagtg tatgcggagt cagctctttc 1951681 ttaatgccgg cttccaatgc gatttttttc aggttcttcc aaaatccctg gcggctgatc 1951741 tgtttgccgt gatgatttaa aaagagggcg tcagatacat tattttttaa cagttttccc 1951801 ctggcttttg tcatatattc ctcaatggcg gaagcagcgg cttcaccgat tggcacaatc 1951861 cgttcttttc ttcctttgcc gaagcatcgg ataaacccca tagataaatg aacatcagcc 1951921 gttttcaatt caatcatttc actgactcgt atgcctgtcg cataaagcag ctccagcatt 1951981 gctttatccc gatatccgaa agggctcgtc agcttaggcg tgtccaataa ccgctcgact 1952041 tcattgagcg cgagcacctt cggaagcgcc cgttccgtct tttgtgtttc gatatgaacg 1952101 gaagggtcct tatccgttac tttttccctg agcagaaatt gatgaaaaga gcgaatggat 1952161 gccaaatgcc gcgccgatgt cttgccggat ttccccgagt ccttcaaatg ctttaagtat 1952221 tggataatat gtatgcgggt aacgtgattc caatctgtaa catgaagggt ttctgttaag 1952281 tagagagaat agcttttcaa gtcacgttca taggatacga tcgtattttg agagagccct 1952341 ctctctacca taacgtagtg gatgaaatcc tttatttgat ctttcactct tgatctactc 1952401 cccgttttgg taaaaaaaga tcaaccggtc gaaccatccg cctttttcat cctgatccat 1952461 ttcaacaact tttacagcgg agccttccgg tttatcatac cgatgatagt tttcatactc 1952521 ttgattcacc catatcatag cataatagaa caaagcggta aaaccggtaa acaggatgaa 1952581 aactttcaat gcatcgacag ctgttttcag gaatcttccc atgtcctaat cgatcctttc 1952641 cctatggttc cagttatata aaccatatgc caaatcagaa aggttttata catagaaaca 1952701 gcaaaaaacc ctttccccat gagaaaaggt tcgcgctcgg caccgtctat tcagtttctt 1952761 ttccgttaca gcggtggcaa atgccgtgaa acgtcaatct atgatcttta atcttaaatt 1952821 tccaatcacg ttcaatgatt tcttccacgt cttcaagcaa atcttcttca atttcatcaa 1952881 cggctccgca ctccatgcac accaagtggt gatgaaagtg agctgcgccc tctttccgaa 1952941 ggtcgtaacg ggacacaccg tctccaaagt taattttatc tacgactttt aattcagtta 1953001 ataattcaag cgtacggtat actgtagcga gaccgatctc aggagatttc tcttttacga 1953061 ggaggtatac atcttctgcg cttaaatggt cttcttcgtt ttcaagcagc actcttactg 1953121 tcgcttcacg ctgtggcgta agtttatagc tggatgagtg cagttgtttc ttaatacgat 1953181 caatacggtt ttccatgtct ttccctccta cgccgcattc catgactcat tataacaaaa 1953241 tacgcgcaga gttccaacta taattattat aaactgataa ataaaatggt tttcttttaa 1953301 taatgatttt aaaaaagtct agatgtaagc ttttccatta aaacaggaga taagtatgct 1953361 tcaaagagag atgaaatcag cgctaaaaac agaatgacca gcagcacaaa ggcataccgc 1953421 ccgaaccatt gaatcggcgc gtcatgcagg cttcgtttca cgaacagctg tctgattaac 1953481 tttaaagaaa acgcaattgc acatgtgccc ataatgagat aagccggaat cagcagcaca 1953541 ttttgcggca aaacggagac aaatgatagg aaaaacccgc ttactcccat ctgattgact 1953601 aggaacccga cagtaaagcc gacgacgatc cctttcagaa agatcataat gaaaataatc 1953661 ggcatcccaa tgacggaaat tcccagtatc cacatcaggc ctaaatactt tgcattatga 1953721 aagatacttt gcccaaacat atcagctgaa cttgcctgtt ttccatccga aagctgtcca 1953781 aaaaattgac ttaagtagta gtataaatct tctttctggc tgatggtcat actgttgaca 1953841 ataatcgcgc caaagatgac acccatgaaa aacagcactg acacaaatat ataaagagag 1953901 agatgatctt tgacatgcct gagaaacatg tccttataag agatttttcg cataccgttt 1953961 cctcccgccc gctctagtga tttgatttaa tagattgtat gaaagaaaca gaaaaacatg 1954021 ccctttttca aaaagaaaca atagagatga atgctaggcg gctttttggg gcacaaaaaa 1954081 atccttatca tcaactgctg tatgatcata aggattctta tgcttccgtt tattcaaaat 1954141 ctcttttttg ctttttgtca ttcttccatg tgtgctgaaa gatggtgtgc tgcctcttga 1954201 taataagacg tcacgtccgc cgtttctcaa tcgatgcccc cgcttctttt tcgcttggct 1954261 ttttgccatg tgatcactcc cttttttatt ttcatagtaa tgataacaaa attgaacaat 1954321 gataagaaaa aaacagcacc tgctacgaca ggtgctgttt agctacattt atttcactgc 1954381 tgtaagagct gcatgctcga cagctgctgc taccgcatga tggacttttg aatcaagcgg 1954441 ctgagggaca acatcacctt gtttagtgca agctgcgatg gcctctgctg ctgcgacaag 1954501 catatcatga ttaatctccg tgctttttgc gttaagcgct cctctaaaaa tccctggaaa 1954561 accgagtaca ttattaacag aacgcccgtc agctgcatat gcggcgccag cctgcagtgc 1954621 ggcctccggc tcaatttccg gcttcggatt cgataaagcc agaatcactt gaccagaacg 1954681 tacaaatgcc ggttttatta aacccggaac gcccgttgta gcaatgacaa tatcacatgt 1954741 ttccataagc tcctcaatac tggaaactgc ctgtccgccg tattgttcga gacggttcat 1954801 tgctgactct gatttgtctg ttccgtatac agcattcaca ccataagcca tgaacatccg 1954861 gcagatggcc acgcctgctg cgccaaggcc gatttgcccc actttcgctt ccttcaggtc 1954921 aacccccgca ctcctgcatg ccgaaatggc agctgccagc gtcactacag ctgtaccatg 1954981 ctggtcatcg tgcataacag ggatgttcag ctcctctttt aggcgatcct cgatttcaaa 1955041 acaatgcggc gaaccgatat cctcaagaag gatgccgcta aagcccggag aaatatgttt 1955101 tactgttttg atgatttctt caggatcact cgtatcaagc agtatcggaa tgccgctaat 1955161 acccgccagc tgatcaaata aagcagcctt tccttccatg acaggcatgc cagccacaga 1955221 gccgatattc ccaaggccta aaattgcggt tccatccgtt acaattgcaa cagaattgct 1955281 gatcgttgta taaatagaag ctttttcagg ttctttttcg atcagtcggc acacgtccgc 1955341 aacacctggt gtgtagacac gtcccagctc tgccagtgaa cggatcggca ttttgctttt 1955401 catttggatt tttccgcctt catgtgcgga caggacttca tcagatacgg tgtgaagcct 1955461 gatcccttct ccgagggcct gtacagccgc gatcacttcc tgaagctgtt cttcattctc 1955521 cacttgaacg gtaatattcc gcattgtgta attgggtccg acttttaccg tctccacttc 1955581 accaatatcc ccgcccagaa ggccgatggc cgtagccacc cttccaagat ttccgggaac 1955641 cgaaggcgtt tcgatcatca gtgtccgaat catgtgtttc gctatcattc agtgatcctc 1955701 ccctattagc ctagtttttc ggctttaact gtattgtttt tcgtatacca tataaatttt 1955761 cctgtataac catagataat tgcaagacct attgctacaa aactgagcca cataaacggc 1955821 agataagaga aggtagaaac acctaaaata ccagccatgt aaatcccatt atcagaccaa 1955881 ggaaccatcc ccgaagtcaa tgttcccccg acctctgagt tacgtgataa cactcttctg 1955941 tccagatgta agcgatcata gctgtcttcc ataattttcg gagtcaaaat aagagataca 1956001 tacatcgcac agccgaagat gtttgctaaa aacgctacga tcagtgtaga caatgtgaca 1956061 ttgccggctg aagttaattt cttttcaaac gttgaaacaa tgacttttaa cacgccgagt 1956121 ttctcaagca gaccgccaaa accaaggcca aagatgatga cgacgagaga atcaagcata 1956181 ccgacaattc caccgcggtt taacaagccg ttcaaaaatt caacatccgt tttaatagag 1956241 aagccgttgt acgcagttgc aatcgcatgg gcaatatcca ttccttggaa aacaacagcc 1956301 cagattgcac cgagtaaagc gccaattacg ataactggca tagatggctt tttcatcgcc 1956361 aataagacta tgacgagaac tgccgggatc agcatccaaa tatgaatgtc aaacgtgttt 1956421 tgcaaagatg attttaagaa ttcaacttta tcaagatcaa tatttttccc gccgtacata 1956481 aatccaacaa ctgtaaagag tatagctgta atgacataag caggtattga taaataaagc 1956541 attgctctca cgtgagccaa tacatcgact tttgatagtg aagaagctag aactgtactg 1956601 tcagacagcg gagacagctt gtccccaaaa taagcacctg aaagaatagc tcccgctact 1956661 agaggaagcg gaatgcctaa cccctctcca attgcgatca tggcaatgcc ggcagttccg 1956721 actgttcccc atgacgttcc tgttgccaca gacataatgg aacaaataat taacgttgcc 1956781 agtaaaaaga tacttgggtg aataaattcc agtccgtaat aaatcaaagt cggcacaacg 1956841 cctccggcaa tccatgttcc gatgagcgcc ccaactgaaa cgagaatcag tacggcttca 1956901 aggccatttg atatcccatg tacaatcgca ttttgtaaat ctttataaga ataaccgagt 1956961 ctaataccta aaagcattgc aataaaccat gaaacaaaaa gcgccagctg tatcggcaag 1957021 tcgagaaaga ctgtaaacga tagaacaagt gctaaaaata ctcctagtac aataataatt 1957081 tcaaatagtg ttggcaatct tacatccttc aaaagaagtc ccccttcatg taaaagctaa 1957141 aacgctttca atatatagtg caacacgtat actatacttc ctcatcccta tgttgtaaac 1957201 agcttattca tccgactatt cggagatgaa taagctgtat tttatacaaa ttttattttt 1957261 ctaatagttc tttccctgcg atacctggtt tggtcatctc atatgggttt aaaataatat 1957321 ccaattcttc ttcagtcagc acatcatgct gcagacaaag atcccggaca gattgccctg 1957381 tcataattgc ttccctggca attctagctg ccgcttcata cccaagatgc ggattgacag 1957441 ctgtgatcac gcctgcgctt ttttctacgt attgcttcat acgcttttcg ttggcttcaa 1957501 tgccttttaa gcagttgtca gtgaacgaac ggaagccgtt gttcatgatg ctgatggatt 1957561 gaagcaaatt aaagacaagc acgggctcca tgacgttcaa ctcaagctgg ccggcttctg 1957621 aagcaaggca gattgtattg tcatttccga taacctggaa cgcaatttgg ttgatcagct 1957681 ccgccataac cggattgact ttccccggca taatagatga acccggctga cgtgcaggca 1957741 gagaaatttc cgcaagtccg gcgcgcggtc ccgacgccat taagcgcagg tcgtttgcga 1957801 tcttcgacat gttcatcatg cagactttta atgaagctga tacctctgta taggcatctg 1957861 tattttgtgt cgcatcaaca agatgatcag cgccgacaag aggaagcccg ctaatatcag 1957921 caaggtgctt tactacctgt ttgatatatt caggatcagc gttcagccct gtaccaacag 1957981 cagttgcgcc catgttgact tcatacaggt gctggcgcga ttgcttgatt cgtttgatat 1958041 cacgctcgag aacacggctg taagcttcga attcctggcc aagacggatc ggaaccgcat 1958101 cttgaaggtg tgtccggccc attttaataa cagagtcaaa ctcctgtgct ttttgcttaa 1958161 acacactatg catatcttcc attgttttca gcagtttttc taagagcttc aatgtggaaa 1958221 tatggatagc agtcgggaac acatcgttcg tagactgtga catgttcaca tgtgtgtttg 1958281 gacttaaatg gatataatct ccctttttat gtcccatgat ttcaagcgcc cggtttccga 1958341 taacctcatt cgcgttcatg ttcatagaag ttccggcacc gccctgaatc ggatcgacga 1958401 taaactgatc gtgccacttg ccttccagaa tctcgtcagc ggcttgtacg atagcttggc 1958461 caattccttc atacagccgt ttcacgtcca tgttggcaag agccgcagct tttttcacaa 1958521 tcgccagtgc gttaatcatt tcctcatgga ttttgtatcc tgtgatcgga aaattttcag 1958581 aagcacggag cgtctgaatt ccgtaataaa catctgcttc aatttgtttt tccccaagga 1958641 agtctttttc cacgcgatat tctttttggc cgtttaacat aatctttaac cttctttctc 1958701 tttgctggtt atcgttttta cattttacag gacaacgtca tcagctatcg gcgtttccat 1958761 aattctcttg acgacaggaa gatccgaaga ctgacctagc gcccacatca attttggcac 1958821 aattgcttct gtgttcatat ttcttgatcg gataattaag tcttggttga ctctgcggcc 1958881 aacctcgtaa atgctcatgt cttcgccttc ttcaagacat tgagtcgtaa tgacgacgac 1958941 aatgccgctt tcgatcagtt cattcacttt tgacaaaatg tctctgcctt caaacggcac 1959001 tcctccgctg ccataactct caatgacaat tcctttgtac atgcttttca gggcatcaaa 1959061 catttcgggc tttaagcctg gatgcagctt cagcagacat acatctgtgc atagtgaagt 1959121 gtcaactgtg aaggtgtcgt tctcaggttc cgttacttgt ttgttgtatt cgatcccgtc 1959181 ttcattgata aaagcgatat atgggtaatt gatgctttca aatgcgtcgt agcttttcgt 1959241 tcttaatttg atcgcacgcg ttccctgaat gactctgccg tcaaacacaa cataaacgcc 1959301 gcccacgcct tcacaggcaa atcgaatggc atctgtaata ttttttttgg catcggtttt 1959361 ttggaacgtg atcggaatct gcgagccggt gatgacaatc ggctttttgg catgctgcag 1959421 catatacgat agtgcggcag atgtataggc cattgtatct gtaccgtgag taataacaaa 1959481 cccgtcatag gcatcataat tttccttaac ggcttctgct atttccaccc agtattcagg 1959541 ctgcatattg gtgctgtcta tattcataag cgactgagtt tccattgtgt aatcgttatc 1959601 aagttttgat acgtaactta ataattcatc agccttgact ccgggagcca gcccattttc 1959661 cccttcaact gaagcaatcg ttcccccagt tgtcaacatc aataattttt tcataccatg 1959721 cacctcttca ctgtatctaa agatgggttg cgagaaggta ttcgcttttc gcatactttt 1959781 aatgcaatta tagacacgga aaataaaata cgcaagacat tattattcaa ttcgcgtaca 1959841 cttcctaata cctatatgat ataatcagct caaggtgaaa aaggagcgga agttcatgaa 1959901 tctagatcgt ttaactgaat tgagaaaaaa gaaaaattgg tcgcttcaat atacagctga 1959961 ccttctcggt atcgcaaaaa gcacatatgc cggctacgag tcaggctacc gacggccttc 1960021 acttgaagcg cttgccatgc tggctgacct ctttgacaca acctgcgatg aacttttagg 1960081 ccgcgagaaa caaaagcaga ctgctcctca ggccatagaa ttggccacgt ggagcagcct 1960141 cgactttacc atttctgttg atggccagcc gctgagtgaa gatgaaatca tccagctgat 1960201 tacctttata cgcacaaaaa gaaaagtaca ggaggaactg agttaatctt tagctcacgg 1960261 tttaatttta ccgtaggttc ctcctcctcc ggctttcaat tccagttttc cggatctcgc 1960321 ttttacgata agcgccgcgg ttttcggcgg gacaacgcga gccaaatctt cttctgcagc 1960381 ctcatgaaga acagccattt ctgttccgaa ggcttttttt agtttgtcca gcgttttcgg 1960441 gcctacaccc ggaacaaatt gcagcgggat ctgatgtaca tatcgcggac gcgggacgcg 1960501 aacttcaagc tgatcactca attcacgcaa tctatcgctg actcccttgg taaatctggc 1960561 ttttccgcaa ttcgcgcacg ctgtttcccc gcttacagca ggctctccgc acgcttcgca 1960621 agccgtctga taatatttcc ccaataacgg gtccaagcca taatttgcga taattttcct 1960681 gtcatcttgt ccctttaatg caagagcaaa ttcagtaaaa tcagctgact gcacatataa 1960741 ttcattatat tctctgccga ttttccccaa cgaatgcgca tcagaatttg ttaaaaaagg 1960801 atacggattc aattgcgata cgtgtgatgc catgtctgta tcacagctta atccaagctc 1960861 caccgcgtct atcatagatg gatcaaaaac ctcagttaag cttgatttaa ccccttttcc 1960921 atataagctt ttatgcggcg taaagatatg ggcggggata aacaggccgc ccatatcctg 1960981 cacttttttt tgcaggttta agcccgtttc ataaatccgc tgcgagctta aatgaatatt 1961041 tttcagccgg gctgacagcc agtttgaaaa ctgtttcata tcagccagcg tcggcataaa 1961101 tacgagcaca tggatcggtc cgctgcaggc ttcatcataa atctccagct cgctccccaa 1961161 taaaagagtc gtgctgcgat aacggattcc tcccccgtca agctcgcgat attttccaga 1961221 tgaaatgcct tcctcaagct ctagaatgac ttccggagaa tgacagtcga taatgccgag 1961281 gagttcaatt cctttatgtt cactggcttc aaccaaaatt ctgtccagcg ttaatgtttt 1961341 ggcgcctgtt attttgacag cccttcctgt aaaggtccgg ccgatatgaa tgtgcaaatc 1961401 cgcgtaaatc tttttcattt ttgtgcttgg agcgcttctt tcagctgaag atactgaatc 1961461 gcgtaggctg ttttagcatc atatacttca cgcgattcaa ccagctttag cgcatcttca 1961521 agcgtcacct ccatcacttc aacaaactcg tcctcatcaa gctcccgttt ttcttcaagc 1961581 acagaaagct cctcagcaag aaaaacgtga acgatttcat ctgcaaatcc gggtgatgta 1961641 taaaacgcag ttatttttgt cagttttttt gctgtataac cggtttcctc ttcaagttcc 1961701 cgaagtgccg tatactccgg ctcctcacct ttttcaagct taccggccgg aatttcaacg 1961761 atcgtccgct caagcggctt acggaattgt ttgaccatga tgattttccc ttcatctgtg 1961821 acggctagta ccgctacagc tccagggtgt ttcacaattt cacgtttact ggctttgccg 1961881 tttggcagct ctacatcctc gacataaaga tcaatgactt tacccgaaaa aatctgttct 1961941 ttggcaattg ttttttcttc taatgatttc atttcttcat ctcccgttct gtctctatat 1962001 gatgccccat acattttatc atactagagc aaaagggggc ttcttcgtga aagtgcaccg 1962061 catgccaaaa ggtgttgtct tagtcggaaa agcatgggaa attcgagcga agttaaaaga 1962121 gtatggacgc acatttcaat atgtgaaaga ttggatctca aagccataaa agttgaaact 1962181 ttagctcctt tatattacgg tcaatacaaa gcctaaaaaa ggagtgtgca catgagaaag 1962241 cgcaaattgg gtacatctga tttagacatt agcgaagtcg gactcggctg tatgtctctt 1962301 ggaactgaaa aaaacaaagc attgtccatt ctggatgaag cgatcgagct tggcatcaac 1962361 tatttggaca cagcggattt gtatgaccgg ggacgcaatg aagaaattgt cggtgatgcg 1962421 atccaaaaca gacgccatga tattattctg gcaacaaaag cgggaaaccg ttgggatgac 1962481 ggaagcgagg gctggtattg ggacccttca aaagcttaca taaaagaggc ggtaaaaaag 1962541 agccttacac gtctgaaaac agattatatc gacctttatc agctccacgg cggcacgata 1962601 gaggacaaca ttgatgaaac gattgaagcg tttgaggaat taaaacaaga aggtgtcatc 1962661 cgctactacg gcatttcttc catccgcccg aatgtgatta aagaatatgt aaaaaaatca 1962721 aacatcgtca gcattatgat gcaattcagc ctgtttgaca gacgccctga ggaatggctc 1962781 ccgcttttag aggaacatca aatcagcgta gtcgccagag gtcctgttgc caaagggctc 1962841 ttaactgaaa aaccgcttga tcaagcttca gaaagtatga aacaaaacgg gtacttgtcc 1962901 tattcattcg aggaactgac aaatgcccgt aaggcaatgg aggaagtggc tcccgatctt 1962961 tccatgacag aaaagtcgct gcagtatctg ctagcacagc cggctgtcgc ttcagtgatt 1963021 acaggcgcca gtaagattga gcagttacgg gaaaatattc aggcagcaaa tgcacggcgt 1963081 ttaaccgaag aggaaatcaa agcgctccaa tctcatacga aacaagacat ttacaaagct 1963141 catcgctcat agcagaaaaa ccagcacctg tacgggtgct ggtttattta tattgatgcc 1963201 aatccatttg gctttcattt aggagttctt caaagctctt atttttttcg atctcttttt 1963261 tctttctaat ctgttctgct ttttctcttt tctgcctctt ttcatcctct tccttcaatt 1963321 ggctcttcat ctccataagc tttgctttga tatcggattg aaggccgtct tttagctggt 1963381 gtttgtcaat ggatttttgt tttttcatgc agacttcccc catgttttgt tttgaagcca 1963441 gtttatcacg gagcatataa actgaacaag cagactctct tctgatcact ttctcagcgt 1963501 agcagtgttt aggtataatg atcttaaaca cgaattgcct atatatttcg ttgaaaggtg 1963561 ctgtgacttt tgaagaaaat ccttttggcc attggcgcgc tcgtaacagc tgtcatcgca 1963621 atcggaattg ttttttcaca tatgattcta ttcatcaaga aaaaaacgga tgaagacatt 1963681 atcaaaagag agacagacaa cggacatgat gtgtttgaat catttgaaca aatggagaaa 1963741 accgcttttg tgataccctc cgcttacggg tacgacataa aaggatacca tgtcgcaccg 1963801 catgacacac caaataccat catcatctgc cacggggtga cgatgaatgt actgaattct 1963861 cttaagtata tgcatttatt tctagatctc ggctggaatg tgctcattta tgaccatcgc 1963921 cggcatggcc aaagcggcgg aaagacgacc agctacgggt tttacgaaaa ggatgatctc 1963981 aataaggttg tcagcttgct caaaaacaaa acaaatcatc gcggattgat cggaattcat 1964041 ggtgagtcga tgggggccgt gaccgccctg ctttatgctg gtgcacactg cagcgatggc 1964101 gctgattttt atattgccga ttgtccgttc gcatgttttg atgaacagct tgcctatcgg 1964161 ctgagagcgg aatacaggct cccgtcttgg cccctgcttc ctatcgccga cttctttttg 1964221 aagctgaggg gaggctatcg cgcacgtgaa gtatctccgc ttgctgtcat tgataaaatt 1964281 gaaaagccgg tcctctttat tcacagtaag gatgatgact acattcctgt ttcttcaacc 1964341 gagcggcttt atgaaaagaa acgcggtccg aaagcgctgt acattgccga gaacggtgaa 1964401 cacgccatgt catataccaa aaatcggcat acgtaccgaa aaacagtgca ggagttttta 1964461 gacaacatga atgattcaac agaataaaaa agcgaaaggc ctcttcggct ctttcgcttt 1964521 tttatgttac agaacgtcgg taatgccatc catattttct ctgatccatt caatcgcaag 1964581 atctatcgtt gtaaactcct gcgtctcgaa ggtcatttca tcctgcaata gccagacatc 1964641 tttcttgatg gactctgctc ctccgattga ccagtgaagc aaggtataag gatggttttg 1964701 attcaggaag gatacccacg ttttattttg tgctgtgttc ttcattgcct tcagcttttg 1964761 ttccacgttt cgcgtctcct actttactaa tatgctcatt ctggggctga gcatttcagc 1964821 cgggcttttc agcgccaatg ttttggcttt ttcattgtaa tcgatcgtca tttgatcgtc 1964881 aaaaaacact ttttgcgacg attggatata cagcggaatg ccgttcgttt ccagctgctc 1964941 gcactgtccc gttaattctt ctgccagcca gattgtcggg acaccgctta ccgcgcagcc 1965001 gcatccttct gcatcgtaac gaagctgggc tttttttccc gggttggcgt caaacgcctg 1965061 ctgcagtgcc tgttttgctg catctgtcac atgtatgttc ataaggtgaa acccccgttt 1965121 tcatcatttt cgctattgta gcatacaata ctgccattcg cattgtttct gccttttttc 1965181 caccgcttcg cattttcttc tgcagtcttg atccactcat ctttcccttg tatatactga 1965241 ttgatgctgt cagggtgctg ggccgccagc tgttttttga gaacggcgta ttctttcgct 1965301 atgtttggat gagctctgag ataatctctg aataacagat gcctttcaat agcagggttt 1965361 ccctgttcgt acatatggac atgatgagtg cgtttatttc cgcccttttg gaaataacgc 1965421 ctgcccgcta taccgttctc accttttggt gtatagccgt tggccttcat ttgttcatca 1965481 aattggctca cggcttcaat gcttctgact tcaattaaca tatcaatgat tggcttcgct 1965541 gccatgttag gtattgatgt gcttccgatg tgatgaatag cgataatctc cggcccgaac 1965601 acaagtttca gccgttcttt ttcttcatcg aaacattctg cccatttttc gttgtagaga 1965661 atgatctcaa cttttctttt cggatacaaa tgaaagaccg acagcaatag accctgcgct 1965721 gctttgacgg tttctgcctt ttggaatccg gcctgtgtat agagtgacac agccggggta 1965781 ttgttctcgg ctgtgactac ttcgattttc tcagcgtctt cattatgatc aatgacaaat 1965841 tgcagaagcg ctcgtccaat tccttttctg aaaccgtcag gatgcacaac aagcctgcaa 1965901 atggtgagat aatgcatgtt tttctcatat gaaatgacac cgatcagctt gccgtttttc 1965961 cgatatcccg caaaccgttc atgggatgct tgaatatcct ttaccttctc ttgtaaagcg 1966021 ggaataccgt caaaaccgat aatctctgtt tcctttatgt aggcggggat ctgtacggct 1966081 aaaatctcac gcgctatagt ggcttcctta tgctggagaa attcaatcat tcgtgttctc 1966141 ctgaaacagc cgctgtctgt cgacttttgc gacgcggact gcatacgact cgtaccaaac 1966201 gcttcttcct ttttcttttg ctgcttgatg ttcagtgtga tgcctccaat ggttaattgc 1966261 gtccatactg tcccaatagg aaactgtgat gccccttcca tccgcttcac gtacgctttc 1966321 cacgcctaaa aatccaggct gatccgccgc aagtgatacc atccgctccg ctgtttctcc 1966381 atatcctgtg tcattttcgc ttttgacaga agaaaaaatg actgcatagt aaggaggctc 1966441 aggtgttttt gataaaaaat ccatcatatt tccccctcat atgtttttga caaatagtac 1966501 cctgtcttgg cccgggccat catagtttgc aaacactgag atgccattta ccgttttggt 1966561 gcccttttca atatcaaacc ccaattttgt gtgatatgcg attgatacct tattcacagg 1966621 tgaagtgaca cacttcaccc gggtgcagcc cctttgtttt actgtttcga taaatacatc 1966681 atacaattgt ttcccaattt gcatttttct gaaatccgga tgcacaccgg aaaaatgaat 1966741 gtacgccgtt tcaggatcgg attgcgattg aaatccgatt aaaaatcccg tcatgctgtt 1966801 atgttcggat gtaataaagc ttgtgtcctg aaaatgctca aaaaatagtc tcggcaattt 1966861 ttctttcagc tgtctgccgc cccaccattc attcagtaca gacgttacca tttcataatc 1966921 tgaagacgtg attgttcgaa tatccattac gatttgatct ccctccgtct ggcaaaacga 1966981 atgtcagctc tttttctcac aatataaaaa ttatattttg cctggctgga attgtaaatg 1967041 ccttctttcc tgtatcatac gtttccagac tgccgaggga acaatgtttg atcattttac 1967101 gcctatttct cccccaaaca ggaggagaga ctttacagca caatatcaag cacttgatca 1967161 agtttcagct tataaagctg atcctcgtct ccttttatcc atactgcttt ttcaaactct 1967221 tcataccggc agattttccc ggtgcagcag acaatctcac cgtcctgaaa gcagctgaca 1967281 gtgatatcct gagcaaactc catcgcggcg caaagcgttt gattcatctc ttccagctta 1967341 tcggggtcaa ggatcggctt ttgcagcttc tgtttaagtc gctttctctc cagcaggctt 1967401 tgcttatgtt ccggcagaaa catcctgctc ccttcccaca gcaggttgcc cctttttaaa 1967461 tggtcgttca tttataatgc ccccctattt tagccgcacg ttcaaatgcc tggcctgccg 1967521 ctgtcagtga cgccgccctg atgattgctg tatcgccgaa tcgattttta atgccatcca 1967581 tcacatagcc taggctcatt ttctttgcat aatcctgaaa taaattgagc tgccatatgt 1967641 catcagatga gagctgagac agattgacac cgaggcggcg gacgggtttc ccgtcccaaa 1967701 atgtaagaaa cagccgtcgt acagcctcat atacatcctg cgtagaatta gtcggctctg 1967761 ccagcttcac ttgccggttg aagcccgtcg gccaatcaaa atcagcaccc cggcagctca 1967821 ctgacactgt ctgccccatg accccggcgt ttcggcttcg cctgcacacc tcttcactca 1967881 gctcaagcaa tacgaccttg atttctttgt caaagtgttc gtagtctctc gggagagtca 1967941 ttccatgacc tatcgccttt tgcccgtcca gagacgaagt tgacacaggg gaatagtcga 1968001 ttccgtttgc cgtcatccac agcacgtggc cgttaatgcc ccatttcttt tttaaaagat 1968061 cgagcggaaa agccgcgagc ccgccgatcg tgctgatgcc cattcgattt aaatgatgct 1968121 tcatgcggct cccgacgcca aacatgctgc ccaccgggag cggccacatt tcggttttca 1968181 tattttcttt cgttaaggta aaaataccgt tcttattctt tttggcaaaa ttgtcacacg 1968241 caattttggc cagcgctttg ttagggccga ttccgacccg tgcataaacg ccgatctccc 1968301 gcatgattct gccctgaatg cttttcgcga tctccatcgg cgtcccaaac agcttctggc 1968361 tgcctgtaat gtccatgaac tgttcatcga tggaatacgg ctccacaagg tctgtatact 1968421 cctcgagaat ggccgtaatt tgcagtgata catcaatata ccgctgcata cgcggccgga 1968481 gcacaacagc ctcaggacac ttttcctgcg cctcccacag ccgtgaagca ttcaccacac 1968541 ccttttgttt cgccagcggg caggcagcca atacgactcc gccccttttt tcagggtcac 1968601 ccgaaacaat gacgggccta tttttcaaat gtggattttc cgctttctct acagatgcat 1968661 aaaacgattg catgtcaacg agaaaaatca ctttttcttt catcatacac acctctaaaa 1968721 agaacttatg ttcgcttttc attatatgcg aaagtatgtt cgttttatac tggtaaatga 1968781 ttcttgtctg acagaaaata tgatccaagg gtttgagaga agaaaaacat ttagtagaat 1968841 aaaagcgaag cataaggata ggagagtcat gatggagaaa tttgtcgaaa aaatgctggg 1968901 acaggcattg cggcaatacg gcagaaacgt tgctatagat ccgttaagcc cgtatgaaaa 1968961 acaaagcctg aaagcggctc tacaagagag acggaatgaa gaaccagatg aggatttgca 1969021 tgcgcatata gaagatatca tttatgacta tgtcacaaac caaggcctgt tctcttaaac 1969081 gcatgactgt cagttctttc agccgctgat gcggcttccc tttgaaaaca ccgcctgaaa 1969141 caaataaaca gtctcaggct tacagaaaaa aagcaggatt ttctcacgct ccatagattc 1969201 atatggcctg gcgtaaaatt cccctcaatg ctcgcgcaaa acggaataag ctgtccatga 1969261 tcacgcgtat acactttttc gaagagatgt gctctcttgt tctgtcatgc ggtccatgcc 1969321 ggttttcagc gtacatcttg atctcatagc cggtttcact gccgatatga tccacgttct 1969381 ggcggcttaa actaacacac cctcactgac caatcgcttt gcttttcatc ggacatcccg 1969441 tcattttcct tctttcaaga tgtaaactcc gtcagccaca cgcatcctca acgcatagta 1969501 tattgccatc catacaatca ggcatactac atgtcaataa cgaaatattt tgaacgatct 1969561 attggagaag gaaatttttt catatatgat agagaaagat catacataca ggagagaata 1969621 taattcatga agaaatggaa agatatccac ccgatcagct ggacaattat aatcggaacc 1969681 attttcggca gaatggcaac atcgatgagc attccttttt tagcgattta tttgacagcc 1969741 gtccaaggcg catcagcttc ctatgcaggg ctggtcatcg ccgcgagctc atcagtcggc 1969801 atcctcgcaa gcttttacgg cggatatatc tcagataaat tcggcagaaa aaacatgatg 1969861 cttgtatcga ttttcggatg gatgctggta tttgcaggct ttgcggcagc atctaatctc 1969921 tgggtgtttt ttgtagtaaa cgcattaaac ggtctttgca aatcactgtt tgagcccgct 1969981 tcaaaggcct tgttgtctga tatgacagaa gaaaaaacga gactgctagt ttttaattta 1970041 cgctatgcgg ctattaatat cggcgttgtc ttcggacctg tgcttggcct atatttcggc 1970101 tcatcgcaat cgactacgcc ctttttggtg cctgcagtca tttacggact atacggaatt 1970161 gtgcttgccc tccaatttaa aaaacatcca tccttatcag caccagccca gtcccgaaat 1970221 atgagcgtgc gggaagcgtt tatggtcacg caaaaggatt atctttttac cattgctttg 1970281 gtcggcatta cgctatgcac cttcggctac tcacaattca gttccacatt ccctcagtat 1970341 atggcgcaga accccttgat cggcaatgga acgaagctgt atgggctgat gctgacatta 1970401 aacgcaatcg ttgtgttggc gacgcaattt cccattgtcc attttgcaaa acggttttcg 1970461 ccgctttgtt ctctgatgct cggtaatgtg atggttagca tcagcatggc cattttcacc 1970521 gtatcacacg gtgttccatc aattgtgatg attgtcatca catttacaat cggcgaagtg 1970581 cttttattct ctatgatgga tttgtatgta gaccagattg caaaaccagg attaaaaggc 1970641 acttatttcg gggcaatcgg tttttcacag ctcggaaacg tcatcggccc ttgggtcggg 1970701 gggatatgta tagacctgtt tggcgctggc cggccgattt atattttttc tgtcctgagc 1970761 ggcattaccc tgctcggcct gccattttta gcgttcgcct atcggcaaat gaaaatggag 1970821 accacaaaac accgttcccg tctggaaaag ccgctttaaa taaaaaacgg aagagaatga 1970881 atctctcccg caaacatgag gtgaagaaca tgaatatagg tgatgtgatg tttcagctgt 1970941 ttgtatttat tatatttgcc gctgtcgtct ttgcggctgt tacaggcttc aagtatgcga 1971001 aaaaccgaaa agcgcagctg gatcgcattg agaaaaagct gaacagcctg tccgaagatc 1971061 acgattaaca gcttggggca acgagctcta ccttaatccg gtctggatcc tcacaaaaga 1971121 ctgcataatg cccgtctcct ccggcaaaag gatgcctgtc tcggtacaac acacgatagc 1971181 cttttgccgt caatttttca gtcatctgat cgacttgaag cttggattca gcatgaaatg 1971241 cgagatggtt cagaccgact cggcatctat ggtattccgg ctctagaaat ggctctttcg 1971301 cctgcacaat cactaggtaa aaacgatctt tcttccagct gatgcctgag ctccattttt 1971361 gatactcttt ataaccaagt tcttttaaga accagcccca aaaccgccta gacgcctcca 1971421 aatcagagac atacagttca atatgatgca catttcatac cctccttacc aacacttcct 1971481 cgaccttatg cccgtctccc ttacgcaaaa tgagatctga cctgaattta gttggcaaaa 1971541 tattttcata taaattcggc cggttgacac tctcccaaat cgaggctgcc atctcgtcag 1971601 cctcctgatc ggacaagtct ttaaatttat gaaaatatga atcaggattt tgaaaagctg 1971661 tttcccgaag caggcgaaaa cgctctaaat accaagtgaa aatccggctt tcctccgcat 1971721 ccacataaat cgaaaaatca aagaaatcgg aaacaaaaat acgcgggttt tcccggtcat 1971781 cctccaaggt gggcgactga agaacattaa tgccttcaat aatcacaata tccgcctgtt 1971841 ctacaacctc gaacacacct tcctcgcggt cataggttag atgggaatac accggggcct 1971901 ttacgctgtc ctttcctgat tttaagtcat tcaaaaattc gagcagcgcc tttacatcat 1971961 agctttcagg aaatcctttt cttgacatca tatttttctt tttcagctcg gcagtaggaa 1972021 ataaaaaacc atctgtcgtg ataaggctca cttttggacg gtcaggcaaa cgcgaaagca 1972081 gcttctgcaa gatccgcgcc gtcgtgcttt ttccgactgc gacactgccg gcaatgccga 1972141 taataaacgg aattttggct gaatgtgggt gcttcaaaaa aacattgaca tgcttattgc 1972201 gttcagccgc agacttgaca tgtaaatgaa gcaagcgaac aagcggaata tagatcgtct 1972261 ccacttcttc aacagataga taatcattca atccttccac agcttttgcc tcttcttcag 1972321 atacagcaat cgacaaatgc cccccaaaac cagaccaaga ctcccgattg tgctgtgtat 1972381 ataaagtatg taggttaagt tctttatttt tcactgttta cacctgactc tctgtaggtt 1972441 aaaaccctta caaagattgt aacggaaaac cttttcactg tctgcttatt tttcatttcg 1972501 tttttttagc aaatcagcac cgattcggtt atacgcagcc atttcatctt ttggaaccat 1972561 gcttcctccc gttccccaga cgacatgtac ggcatgttcc atcttatatt tctgagcata 1972621 gcgccttccc tcttctgtcg aaaaaagctg aaccggcccg aacatgccag caagagcaga 1972681 gggctctaaa tatttatctt cagatacagc cagcatatga agcaaagtat aaagcgtatt 1972741 gtcctctacc gtataacagc cgctcagaag cggttcaatc agcttgccga caaatcctga 1972801 cggcctccct acggcaagtc cgtcagcagc cgtctgatta tccaggccga tatcctggac 1972861 ggagatcttc tcgtgaagtc ctgaataaag ccctaacagc atacaaggtg aatgagttgg 1972921 ttctgcgaaa aacacatgaa catcatctcc gtataaaagc ttcagcccaa atgctacacc 1972981 gcccggtcct ccgccgactc cgcacggcag atacacaaac aagggcgtct caagacttgg 1973041 ctttatattc atacagtcaa gctgtgtttt taatcggctt gcagcaacag catatcctaa 1973101 gaacagctga cgagaatgtt catcatcaat aaaataacag aatggatctt gttccgcctg 1973161 ccgtctccct tcgttcaccg cttcactgta atctgtttcg tactccataa cagtgactcc 1973221 cttttggcgg aggagatcct ttttccactg cttagcatcg gcggacatat gcactgtcac 1973281 gcgaaacccg agtgccgcgc cgatgatgcc gatgcttaaa cctagatttc ctgtcgaacc 1973341 gacagcaatc gaatagcggg agaaaaaccc ggtaaaccgc tcttcctgta agatgcggta 1973401 atcatcggtt tcctgaagca ttccttcttg aagcgcgaga ttttcagcat actttaacac 1973461 ttcataaatc ccgcccctcg ctttaatcga tcctgaaatc ggaagctcat ggtcgcactt 1973521 taaaagccat cttccgggaa atggctgctg atatgccgct tccagctttc ccttcatatg 1973581 ctgcacctca aaaagcggag actcgatgat tcctttagcg cctttcgtct caggaaacac 1973641 ctcggcaatg taaggtgcaa accgctgcat tcttttttcc gcttccgcta tctcggttgc 1973701 ccactcatct gcacggggta atggcccctc tttcttgcct gaatttgccc agaatacagg 1973761 ctctgcatca atcagtttct gaataaacgg atctttaagc agagcatgaa ggacttctga 1973821 atgaactgac attcaacaat ctctcccttc cactatcaaa aactgccccg tgagaaacaa 1973881 gccactccac cacaggcagt tctatcatta ttttttcatg agcgcgcgtc ctgccagctt 1973941 ttctacaaga gctggaaaca gctgatacag cttagtgccg gcattcatta aacgcggaag 1974001 attgatctcc cgctttttcg taaaaattgc agctgtaatt tgagctgcca cgtcatcagg 1974061 atcaagcatc cagcggccga catttttggc gtagtccccg cctttatcag caatggaaaa 1974121 aaagtccgtc tgaatcgggc ccgggttgac tgttgtcaca taaatgccgg ttcccgaaag 1974181 ctccatccgc aaagcgtttg agtaacctaa cacggcatgt ttggtcgcgg aatacaggct 1974241 agacttcggt gtggcgattt tccccgcttg agaggcgata ttgatgatat gtcccttttt 1974301 ttgctcaagc atttgcggaa gcaccgcttt tgtacaggcg atcaggccga agacattcac 1974361 atcaaacatc gctttcatgt catccaatgt agagtctaaa accgtttcaa atataccgaa 1974421 gcctgcattg ttaatcagta catcaatcga gccgatctga tcgcggaccc gggcgatatc 1974481 ctctaggcgg ccgacatcca gaggaaaaat ctcacactgt ccgctccatt cctcggttat 1974541 tttccttttg atttctatca aacgatcctc gcgtctagcc gacagcagga catgggctcc 1974601 ttcagccgcg cataagtatg cgattctttc tccaagccct cctgaagcgc cggttatcca 1974661 aatccttttt cccgctatat gtttcaccca tttcacctct tcattgtttt aaagtatacg 1974721 gtatttcctt cccaatatga cgtgatggct tcttcagcct ccaacacatc aaggtgacct 1974781 gccgtttctg acatcgttaa aaacaattcc ttttcatata cagcaggaaa aagctgctga 1974841 cagacctgaa aagcggtcat cggcttttca tccagcatgc gacgcacatc ctccgtcctg 1974901 ttcctctgct tgtcaaaacg cttctcaatc agcgcttgta cactggtgat aggctcgccg 1974961 tgaccaggaa atacgattgt tggatcaagt tgagacagcc ttcgcaatga ccgctgataa 1975021 tccactaaag gctttgacct gacgtctccc gctttcggcg cttccaaaat cggattagac 1975081 gagctgtttg ccagcagtag atcgccgcca agcatccttc cgcttttttc atggaacaga 1975141 acaatatgcg attcagcatg tccaggcatc tccaacacag accagccctc aagcccatct 1975201 atgcccatac cttctctgat tgattttgtc agagatctcg tacaggaaaa tgcgtacgct 1975261 gatcgaatca gcttttccgc cttccccgta tcaaatggaa cgcctaattc aggcagcagc 1975321 ttttgaaaaa aacgtttttg ccaatccata aaggcttgat tttggctgat ataaggttcg 1975381 ttgaatgtat gcccaatcac ttcgatttca tctgaaaaga catcaagcaa gcctgcatga 1975441 tcagcatgat ggtgagtcag tacaacctgc tcgatatctg acaatttcac atttacagcg 1975501 gcaagctgct cttgtaaggc tctggcagcc tcttttgtat tcggcccggc atcgataagt 1975561 gtcagcgcat caccttttac gaggtaaacg ataacatcgc cgacagcaaa cggtgtcggg 1975621 acgcggatcg caattacatc ttcagttgtc atcctttcgc tccttgtctt cattcattat 1975681 tcatatttta gctttttctc ggtcttgtgt cattattgca gaatgagaac aaaccttttt 1975741 gaaaaagcta ttgacattag cttgtccgcc attgcataat gaacaacaaa ctaaaacgag 1975801 aaccattgga acgctatgac gaggaatagt atacaaggca atggcctaag agagcgatac 1975861 ccccggctga aaggtgttgc ggcccgcttg tttgtagaac ctgccctcaa gtcgcggtta 1975921 ggaaaaccta aacgtttccc gcgttacggg gatttgagct gagcacaatt tgtgctaatg 1975981 agggtggtac cgcgaacctt ttcgtccttt acgtgatgaa aaggtttttt gttgttctaa 1976041 tagaaggagg atatcaatga aaaagatagg atttgtcggc gccgggtcaa tggcagaagc 1976101 aatgatcaac ggcattttgc aaagcggcat cacaaaacca gaacatatct atattacaaa 1976161 tcgctcaaat gacgagcgtc tgattgaatt aaaggaaacg tacagcgtgc gtccatgcag 1976221 agataaaaat gagtttttca ctcacaccga tatcattatc ctcgctttca aaccgaaaga 1976281 cgcggcggaa agcatcgaca gcatccggcc gtatatcaag gaccagcttg tcatttcagt 1976341 acttgcaggc cttaccatcg aaaccattca gcattatttt ggcagaaagc tcgcggtcat 1976401 tcgcgtcatg cctaatacat cagcggcaat cagaaaatca gcaaccggat tttccgtaag 1976461 cacggaagca agcaagaatg atattattgc cgcaaaagct ctattggaaa caatcggtga 1976521 tgcaacactg gttgaggagc ggcatcttga cgctgtcact gcaatcgcag gcagcggccc 1976581 ggcctatgtg tatcgttata ttgaggcgat ggaaaaagca gcacaaaaag taggattaga 1976641 taaagaaacg gcaaaagcac tcattttgca gacaatggca ggggcaacag atatgctcct 1976701 ccaaagcggc aaacagccgg aaaagctgcg taaagaaatc accagtcctg ggggcactac 1976761 agaggcaggt cttcgcgctt tacaggactc ccgctttgaa gaagcaatta ttcactgtat 1976821 tgaagaaaca gctaaacgga gcgcagaaat caaagaacag tttgccggtg ccgccttaga 1976881 gagacattct tagatgtaag gacaaaaaca gaaggcacag tgccttctgt tttttatttt 1976941 tcccgcagca gctggccggc agattctgat tgctttaata gcgcggagat cgtaaatgaa 1977001 agcaaatcgg gaagcacttc aaaggaataa ggcatataca atctttccgt ccatttatgc 1977061 gggtctttac cagccggacc gacatttaaa actgggacat ataaagcctg atttttaccg 1977121 cttggcaatg aataccctct gttaaagagc ggcatattgc ttgtgtatgc atcaacctcc 1977181 tgtttttcca gctgaagata actcaagtcc gaaagtccgg ggaagtactg aacctcccgt 1977241 aatgcaatgc cgtatcgctc agccgcataa tgctttatct gatctgctgt atttctgatc 1977301 aattgatcat cctttgaaga aacagctgga taaagcggcg gactataaaa cagaacgatg 1977361 agcggcgcat cctccttaca aagcgaagca agctcagaaa caattttcgt cgaaaaatcc 1977421 ctgtctccaa gctcccccct gttagcaaag gcataattta gagcccgctc tgtttccgag 1977481 atccccgcac gcttttttgc acgcgagacc agctcatcaa atgtcaaaac agtgacgtcc 1977541 cgctcaatcg gctgaaatgg ctcaaattgt tgaaaatcct gtgttttctt ccgaacgttc 1977601 gacatgattt cctccgccgc ctgttctgct gttttaagca gcatctgatg cagctcacta 1977661 gctgagcgtt tcattgacag cacattaaat aatgtgacgg ctgtatgcgg tgtctggact 1977721 gaatatgcct ctttcaagtc cttttgcatt aagtttaccg gcggcggagt gacctcgcca 1977781 tcaacctttt cgcaataatc agcattcagt tcaagcaaac ggttaatctc agataccatt 1977841 aaatttgcgt ttagacctga aaacggctct ccaacatgtg tctcaatccc cttgcagaaa 1977901 aaacccgcaa gcaccttgcc aatgcttcct gtataaaaat attgctgctg atcgccggga 1977961 aatttttcaa acatcggttc ggcattcagg caagcggtta atgtgatatc atgctttttc 1978021 tccatctcct tcaatgcagg aaccgcttca atcatgcctc ttgaattcac ttcctcgtcc 1978081 ggaaccgtta tcaacagcag attgccctca aaatgcccgt tcattgccct ctccagcatc 1978141 gacagttgaa tacaaagccc cgctttcata tccatcgtcc ctcttccgaa cagccagtct 1978201 ccgctttcgg catctcttct cacacgttcc gggagcagct cttttttctc taaaaaggag 1978261 ctcaaaagct cagcaggctt gcaagccata tgtttaaatt cgccgtaatc ttctatgtca 1978321 acgacatcaa aatgactcag cagaagcact gtctttttga cattcttctt tttgactaga 1978381 gccgtaagaa aagatctgcc atcgtccatc ggatgaagtg ttacatcatc agggtgcttt 1978441 tgaaaatagg gcttgtcctt caaaataaaa taaagatact ctgcaagcgc tacctcgccc 1978501 tttgaaccgg tgatgctttc gtattgcaca agagaagtta aaagtgccag caattcgtcc 1978561 ttcgtctgcc aattcattga ttccgcccct cctatgaata aaaatgcttc tatactgaaa 1978621 aataaactga tttctcgtct attatacaga aatgtttgac aaaagcggtt catttgagca 1978681 gtttatatga cgggaaagaa atgacttgat ataatcaatc tctaaaaacc ttacgggagg 1978741 cgaaagaaat ggccagaaaa ttatttacac ctattacaat taaagatatg acgttaaaaa 1978801 accgcattgt catgtcgcca atgtgcatgt attcttctca tgaaaaggac ggaaaattaa 1978861 caccgttcca catggcacat tacatatcgc gcgcaatcgg ccaggtcgga ctgattattg 1978921 tagaggcgtc agcggttaac cctcaaggac gaatcactga ccaagactta ggcatttgga 1978981 gcgacgagca tattgaaggc tttgcaaaac tgactgagca ggtcaaagaa caaggttcaa 1979041 aaatcggcat tcagcttgcc catgccggac gtaaagctga gcttgaagga gatatcttcg 1979101 ctccatcggc gattgcgttt gacgaacaat cagcaacacc tgtagaaatg tcagcagaaa 1979161 aagtaaaaga aacggtccag gagttcaagc aagcggctgc ccgcgcaaaa gaagccggct 1979221 ttgatgtgat tgaaattcat gcggcgcacg gatatttaat tcatgaattt ttgtctccgc 1979281 tttccaacca tcgaacagat gaatatggcg gctcacctga aaaccgctat cgtttcttga 1979341 gagagatcat tgatgaagtc aaacaagtat gggacggtcc tttatttgtc cgtgtatctg 1979401 cttctgacta cactgataaa ggcttagaca ttgccgatca catcggtttt gcaaaatgga 1979461 tgaaggagca gggtgttgac ttaattgact gcagctcagg cgcccttgtt cacgcagaca 1979521 ttaacgtatt ccctggctat caggtcagct tcgctgagaa aatccgtgaa caggcggaca 1979581 tggctactgg tgccgtcggc atgattacag acggttcaat ggctgaagaa attctgcaaa 1979641 acggacgtgc cgacctcatc tttatcggca gagagctttt gcgggatcca ttttttgcaa 1979701 gaactgctgc gaaacagctc aatacagaga ttccggcccc tgttcaatac gaaagaggct 1979761 ggtaatgccc ataagagata tcctgtagag gatatctctt tttttatttt tagagaaacg 1979821 atcggctaag gttctccgtc tccctagtag aaccaattag aggagatgac tccaatgaaa 1979881 tcagcttgga tggaaaagac atatacaatt gacggatgtg cgtttcatac acagcaccgg 1979941 aaaggatcaa gcggtgtaac gattgtcttt gaggccggct atggtacttc ttctgagacg 1980001 tggaaaccat taatggcgga cattgatgat gaatttggca ttttcacata tgatcgggca 1980061 ggcataggaa aaagcgggca aagcagagct aaacgaacag ctgatcaaca agtgaaagaa 1980121 ttggagagtt tgcttaaagc agctgatgta aaacctcctt atttggctgt ttcacactca 1980181 tacggagctg tcatcaccgg tttatgggcc tgcaaaaaca agcatgatat tatcggcatg 1980241 gtccttcttg acccagcttt aggcgattgc gccagcttta cctttatacc cgaagaaatg 1980301 cacaaatcac atacgagaaa gatgatgctt gagggcacac atgcagagtt ttcaaaaagt 1980361 ctgcaggagc tcaaaaagcg gcaagtccac ttaggaaaca tgcctcttct tgtgttgtca 1980421 tcaggagaac ggactgagaa attcgctgct gaacaggagt ggcaaaactt gcacagcagc 1980481 atattgtctc tatctaacca aagcggctgg attcaagcta aaaacagctc ccacaacatc 1980541 catcatgatg aacctcatat cgttcacttg gctatttatg acgtatggtg cgcagcgtgc 1980601 cagcaggccg ctcctcttta ccaggcagtc aattaacgta aaaaaagacc gggccgtaag 1980661 ggattcccgg tcttttatat tattttgttt cacggtgaag ggtatatttc tttaaacgcg 1980721 gtgaatattt tttcagctcc aaacggtctg gattggtgcg tttatttttt gttgtgatgt 1980781 aatttcggtc tcccgtttca gtgcaaagct aaagtaacat ttactctcat aattaacatc 1980841 tccttataaa acgtaatgat tacgttttat tatacaacgt catcacaaat tgtcaaataa 1980901 gagctccgcc ttcagcctcg cgggacgttt acctctaaga aatcatatgc cgccacgcta 1980961 ttggggaaaa cgtcaaccgc ttctttttga agctccaaag aagcatctcc ctgatatctt 1981021 gcgctgatat gggttaaaat gagctgcttc gctcttgctt ctttcgctgt tacagccgct 1981081 tgttccgttg tactgtgata ataatcataa gcaagtttac ggtcttcctt agcaaaggtt 1981141 gcttcatgaa caagcacatc acaatccctc gcaagctctt ttagtttgtc acttactctc 1981201 gtatcaccgg agaacacaac agatcttccc tttttaggag gctccagaaa atcattccca 1981261 ttgatgattc gtccgtcttc aagcgttacc gtttcgcctt ttttgatttt ctgatataca 1981321 ggtccgggcg ggatgttcat ttcttttaat acgtcagcct tcaaggaacc cggtacgtct 1981381 ttttcctgca cacggtaccc gaaggcttcc actccatgaa taacagatac cgctgtgaca 1981441 ataaactgat cgtcctcaaa cacgattcct tcttcaattt cctggatcgc aagcggatat 1981501 gtcaaatggg ttttcgtgac ggcaaggctt gtttcaataa acgccttgat ccctttaggt 1981561 ccgtacactg tcagctcgtc ctctccgcct tgaaaggaac ggctccccag aagccccgga 1981621 agtccgtata catgatcgcc gtgcatgtgt gtaataaaga ttttctctat tttacgaggt 1981681 ttaatcgttg tatgtaaaat ttgatgctgt gtggcttccc cgcagtcaaa aagccatacc 1981741 gaacgccttt cttcaagcaa ttttaatgcc accgacgtta catttctcgc cttggcgggg 1981801 atgccggctc ccgtccctaa aaaaagtaat tccacgtttc cttcctccta ctagaaccag 1981861 atacctacaa gaatacagga tcaagcggaa aatgtgaatc ttgcctctga aaagaacaat 1981921 cctttcgtgc tagaaacatt ttttcagcat tctgcttaaa aaagggctta aatgtttgct 1981981 ttcgttgaat tttagattta aaatgaagga aatatacggg gtgtactaaa ataaagcttc 1982041 gaataaagtg aggtactttt agtgaaaaca aaccaacaac caaaagcagt aattgtcata 1982101 ttcggtgcaa ctggagattt agcaaaacga aaattgtatc cgtctattca ccgtttatat 1982161 caaaacggac aaatcggaga agagtttgca gtggtaggag ttggaagaag accttggtct 1982221 aatgaggatc ttcgccaaac tgttaaaaca tccatttcct catctgcaga taagcatata 1982281 gatgatttca cgtctcattt ttactatcac ccgtttgacg tgacaaaccc tggttcttat 1982341 caagagctaa acgtattgct taaccagctg gaagatacat atcaaattcc taacaacaga 1982401 atgttctact tggcaatggc tcctgaattc ttcggaacga ttgcaaaaac attaaaatca 1982461 gagggtgtaa cagctacaac cggctggtcc cgccttgtca tcgaaaaacc gttcggccat 1982521 gatctgccaa gcgcacaggc attgaataaa gaaatccgcg aagcatttac ggaagatcaa 1982581 atttacagaa tcgaccatta tctaggcaaa caaatggttc agaacattga agtgattcga 1982641 tttgccaatg cgattttcga accgctttgg acaaaccgct acatttcaaa cattcaaatc 1982701 acatctagcg aatcactagg cgttgaagac cgcgcaagat attacgaaaa atcaggcgcc 1982761 cttcgcgaca tggtgcaaaa ccatattatg cagatggttg cccttcttgc aatggagccg 1982821 cctatcaaat tgaacacaga agaaatccgc agcgagaaag tgaaggtgct gagagcactg 1982881 cgtcctattg caaaagacga agtggatgaa tactttgtgc gcggacaata tcatgctggt 1982941 gaaattgacg gtgtaccggt tcctgcttat acagatgaag ataatgtcgc tcctgactcc 1983001 aatacagaaa cctttgttgc cggcaagctc ttgatcgaca acttcagatg ggctggtgtt 1983061 ccattctaca tcagaaccgg aaaacgaatg aaagaaaagt ccacaaaaat tgtcgttcaa 1983121 tttaaggaca ttccgatgaa cctgtactac ggtaatgaaa acaacatgaa tccgaacttg 1983181 cttgtcattc atattcagcc tgacgaaggc attacgcttt acttaaatgc taaaaagctt 1983241 ggcggagcag cacacgcaca gccaatcaaa ctcgattatt gcagcaattg caatgacgag 1983301 ttgaacaccc ctgaagcata tgaaaaacta attcacgact gtcttcttgg cgatgcaaca 1983361 aactttgcac actgggatga agttgccctt tcttggagct ttgtcgactc tatttctgaa 1983421 acatgggcag caaacaaaac cttatctcct aactacgaat caggctcaat gggaccgaaa 1983481 gaatctgatg atcttttggt gaaagacggc ttacactggt ggaacatata ataagaagaa 1983541 aaaagccgaa aatgtttaca agcattttcg gcttttttac gctgaacaaa ggtataacaa 1983601 tctccttaat aacaaaaccc ccaaagctta agagcttcgg gggtttctat tgattacttc 1983661 atccattcag tatggaagat gccttctttg tcagtacgct cataagtatg agcgccaaag 1983721 tagtcgcgct gtgcttggat taagtttgca ggcagtacgg ctgtgcggta gctgtcatag 1983781 taggctaatg cgcttgagaa tgatggcacc ggcacacctt gggcaactgc aagtgaaatc 1983841 acttggcgaa gcgctccttg atagctttct acaatattct tgaaatagct gtcaagaagc 1983901 aggttgtcaa gctcaggctc gcgatcgtaa gcttctttga tcttctgaag gaatgccgcg 1983961 cgaatgatgc aaccaccgcg gaagatcata gcgatttcac catatttcag atcccagttg 1984021 tattcttcag aagcagcttt catttgggca aatccttgcg cgtatgaaca gattttactc 1984081 atgaacaacg cttttctgac cgcttcaatc agctcttctt tattttctgt aacaggcttc 1984141 acttctggtc ctgaaagaag tccgctcgct tttacacgct cttccttcat agctgagata 1984201 aagcgtgcga atacagattc agtaataatc ggaagcggaa cgcctaagtc aagtgcgctt 1984261 tggcttgtcc attttcctgt tcctttttgg cctgctttat caagaatcac atcaacaagc 1984321 ggtttgcctg tttcttcgtc tttttttgtg aagatgtcag ccgtaatctc aatcaggtag 1984381 ctatcaagct cacctttatt ccattcagcg aaaacttcat gaagctcatc agcagaaagg 1984441 cccagcacct gtttcagaat gaaatatgat tcagagatca gctgcatatc tccgtattca 1984501 attccgttgt gcaccatttt tacgtaatgg ccggcgccgt ccggaccgat atatgtcgta 1984561 caaggttctc cgtcaacttt tgcagaaatg gcttcaagaa tcggttttac aagctcatgt 1984621 gcttcttttt gtccgccagg catgatagaa ggtcctttaa gcgctccttc ttctccgccg 1984681 gaaacgcctg ttccgataaa atgaatgccg ctttcagcga gttctttgtt acggcgctgt 1984741 gtatctttat agtatgtatt accgccgtca attaaaatat catccttctc tagatgagga 1984801 agaagagatt gaattgtcgc atctgttgca gttcccgctt taaccattaa taagattttg 1984861 cgcggtgttt ccaaggattg gacaaattct tcaatgctgt aagtgccaac aacatttttt 1984921 ccttttgcct cctgtaaaaa ctcctcagtt ttactgcttg atctgttgta aacagaaaca 1984981 gaaaatcccc ggctttcgat atttaaagcc agatttttac ccatgaccgc aagtccgata 1985041 acgccgattt gttgttttga catattctaa cgtcccttct gcaaacgttt aatcatttta 1985101 aaatttaaat taaaataaaa tgatatttat aataaagaaa ttaccataca ttcacccttt 1985161 ttttcaagcg attcagcttt tcttttcatc ttgaaaaaaa tctttattaa agcttgttcc 1985221 ctttgttttg ctctcctctt tttttaacgt tgcccctttt ctgatcagtt tggtaccgta 1985281 ctttttattc agcttttcca tcatctgctg aatgggctca tccttcgcat cttcattaaa 1985341 gctgaacaaa tcgagctgtt tataggcctg ctctttttct actaaatccg ttccggtaat 1985401 gccaagcagc ctgacaggat ttttattcca atgtttaaaa aagaggtgct ccgcttcttt 1985461 caaaatgtca tttttttgat caatcgggtt tctcagcgta gtgcttcttg tgatggttct 1985521 ccaatccgca tatctaatca taataaaaag cttcgaagcc atgacttcct tgcgctgtaa 1985581 acggtcactc acagaagcgg caagctttct aaaaacgcct aacagctctt cttcatcact 1985641 ggaatcatgg gaaagtgtcg atgagttgcc gacgctttta aattcgtaaa tgcgctccgg 1985701 gtcaaccggc gcatggtgaa tgccatttgc tttattttta aggcgcggac cgttgatgcc 1985761 aagcaggcgc ttcagcgagt gttcatcagc tgcagctagc tctccgattg tatggatgcc 1985821 gagtcccttc agtttttccg ctgtcttttt gccgactccg tgcatctctc caacaggaag 1985881 cggccacagg atatcgggca cttgcctctt tcttaagatc gtaattccaa gcggtttttt 1985941 catatcagac gccatcttag cgagaaattt attcggtgca atccctatgc ttgacgggag 1986001 cagcagctct ttttgcagcc tgctttggat ttcttttgcc gtctctagag cgcggctgct 1986061 gtatggtgta tcggtcatgt ccatatagcc ttcgtcgatg gagacaggct ccactaggtc 1986121 agtatattca cgaagaatgg taaacatcgc tcgtgaagag tttctatagc ggtcaaagtt 1986181 cggcggaaga acgatgagct caggacaatg gcgcttcgct tgccaaaccg gcatcgttgt 1986241 tttgacgccg cgcgctcttg cttcgtagct gcatgttacc acaatgccct ttcgctcctt 1986301 tacgtttccg gcaactgcga ccggctttcc ccggagagcc ggatcatatg ccatttcaac 1986361 cgacgcataa aagctattca tatcaatatg gaaaataatt cggctctttc ccggcataaa 1986421 caaatctcct tttcggtcat tagacaacag cttgtacata tagtaaaatg aagctattga 1986481 atggatgtga tgacaatgtt tgtggaatcg ataaatgacg ttttattctt agtcgatttt 1986541 ttcacaatta ttcttcctgc tctaacggca atcgggattg cattcctctt acgggagtgc 1986601 cgtgcgggcg agcaatggaa atcaaaacga acagatgaac atcagacggt ctttcacatt 1986661 aaccgaacag actttcttat tattatatat catcgcatta caacttggat acgtaaagtc 1986721 ttccgcatga attcgcctgt gaacgatgag gaagacgccg gttctcttct tttataaacc 1986781 gcatttataa aaaggaggag aacaaaattg ttaaaaacat atcaaaaact tttggctatg 1986841 ggtatctttt tgatcgtatt atgctcgggc aatgctgcat ttgcagcgac taatcaggtg 1986901 ggaggcctca gcaacgtagg ttttttccac gattatttaa tcgaaccgtt ttccgctctg 1986961 cttaagggtg ttgccgggct gtttcacgga gaatacggac tctctattat cctcgtaacc 1987021 attattgtgc gtatagttgt attgcctttg tttgtcaatc agttcaaaaa acagcgcatc 1987081 ttccaagaga aaatggccgt tattaaacct caggttgaca gtatccaggt taagttgaaa 1987141 aagacgaagg acccggaaaa gcaaaaagag ctgcaaatgg aaatgatgaa gctgtatcag 1987201 gagcataata tcaacccgct tgcgatgggc tgtcttccaa tgctgattca gtctccgatt 1987261 atgattgggc tttattacgc gattcgctca acacctgaaa ttgcgtcaca ctcgtttcta 1987321 tggttcagtt tagggcaatc tgatattctc atgtccctta gtgcagggat tatgtatttt 1987381 gtccaagcct atatcgctca aaaactgagc gcgaaatatt ccgctgtccc gcaaaaccct 1987441 gcagcgcagc aatccgcaaa attgatggtg ttcatcttcc ctgtgatgat gacgattttc 1987501 tcgcttaatg tgccggcagc ccttccgctg tactggttta caagcggact gtttttgaca 1987561 gtgcaaaaca tcgtccttca gatgacgcat cataaaagta aaaaaacagc cgctcttact 1987621 gagtcggtga aataaaaaag caaccccgtg caaaaagccg gggttgtttt ttgttacttg 1987681 caaagtaccg cgccaaacag tcttgtttat catggctgaa gcagaaatgg ccatcctaaa 1987741 aaatagccgt atcgtttaaa aagaaggaaa tcgggaatac ctttactcac ctccaaccga 1987801 aaggagccta tacgttgacg gaacgctttc agcaaaaaaa tatttctgta cctgatggaa 1987861 tctggatcat gagacaaacc tggaatgatg tcttatttgc tcactggcct gttgatgttt 1987921 ctatccttcg cgctttggta ccgtccgttt tagaattaga tacatataac gggcaagctt 1987981 ggatcagcat gcttcccttt atgctcacga acctgagggc gcgttatctc cctgtcattc 1988041 ccggtgcgcg tgcatttcct gagcttaacc tccgcaccta tgtcacgtat aaaggcaagc 1988101 ccggcattta tttttttagc ttagatgccg atcatcgtct ggcggtcctt ggcgctcgca 1988161 cattctttca tctgccttat ttttacgcgg atatgaagtc cgaaaaaaac ggtgatgcca 1988221 ttgactatgt cagcaagcgg aaaaatgaca aagaagcagc attccacgcc gcataccggc 1988281 caatttcagc gccttttaca gcagaaaagg attcgctcga ttactggctg acagaacgat 1988341 acaggctcta caccacttat cgcaataagc tctattacga agacatccat catcatccgt 1988401 ggctgctgca aaacgccgaa gcagaaattt cagtcaatac ggtgactgat gctcacggta 1988461 ttacattgcc ggagtcagac cccttgcttc attatgctaa aaaacaggat gtgttatttt 1988521 ggccgcttag gaaatggagc taaaaaaacc cgatgcggga aatcgcactc gggttttctt 1988581 tttttatttt gccgcctctt caataatggc aacaaccatt tctgccgttt taacgagctc 1988641 ttcgatcggc attttttcat tttttgtatg gatttgctca taaccgacag caagattgac 1988701 cgtcgggatg ccatgaccag cgattacgtt cgcgtcgctt ccgccgccgc tcgtttgcag 1988761 ctcgcttgga cgtccgattt tagcagccgc ttttttcgcg atttcaacaa cttggtcgcc 1988821 gtcttgatat ttaaagcccg gatacataac ctcaatttcg acttctgcgc gtccgcccat 1988881 atcagcagct gcctcttcaa aagcagcttt cattttttga acctgagctt ccattttctc 1988941 aggaactaaa gagcgcgctt cagcaagaat atgaacttcg tcgcacacaa tgtttgtttg 1989001 tgtgccgcct tcaaaccggc cgatattagc tgttgtttct tcatcgatac ggcccaatgg 1989061 catttttgag atggctttgc tagcgattgt aatcgctgaa atgccttttt caggttcaac 1989121 cccggcgtga gcggttttcc cgaaaattgc cgctcttacc ttcgcctgtg tcggcgcggc 1989181 cacaatgata tttccgactt ttccgtctga atcaagagca tagccgtagg atgcagtgat 1989241 catagaacgg tcaagcgcct tcgctccgat cagacccgat tcttccccta ctgtgatgat 1989301 gaattcaatc gtgccgtgtt caatattttc ttctttcagc accttaatcg cctcaaacat 1989361 tgcagccaat cccgctttat catcagcacc taaaatcgtc gtgccgtcag ttttgacgta 1989421 accgttctct acaactggtt ttacgccgtt tccgggtaca actgtgtcca tatgagatgt 1989481 aaaatagatc gtatctgttt gttttgtccc ttttagcgtg caaatcaggt taccggctcc 1989541 gtggcccgtg atatccattg tatcgtcttc tttaacgtcc acacctaaat cagaaaattt 1989601 tcgtttcagc actttgcaga tttcagcttc gtgctttgtt tctgagtcaa tttggacaag 1989661 ctctaaaaat tcttccagca ggcgtttttc attcaccatt tgtaagtccc tccatattaa 1989721 agcggtatgt taccgtgctt ttttttcggt ctctcttctg tcttatgtgt aagcatatga 1989781 aaagcttgaa tcagtcttcc ccttgattct tccggcaaaa tgatgtcatc gaccattcca 1989841 caagcggccg ctttgtatgg gccggcgttt tgctttttgt attcagcagt tttttcgcgt 1989901 ttcgtctttt gcgggtcagc tgaagctttg atttcctttt catacaaaat cgatgccgca 1989961 ccttctggac ccatcactgc gatttcagca ttcggccatg caaacacaag gtccgctccg 1990021 atcgctttgc tgttcatggc cacataggcg ccgccgtacg cttttctaat gatgagtgtg 1990081 acttttggga cagtcgcttc agcataagca aacaataatt ttgctccatg cctgatgatt 1990141 ccgttgtgct cttgctgaat acccggcaga aaccccggga catcttcgac agtcaacagc 1990201 gggatatcaa atgcgtcaca aaaacggatg aaccttgctg ctttatcagc agcgtcaatc 1990261 gtcaggcttc ccgccagatg cttcggctgg ctcgccacga tgccgattgc tttttcaccc 1990321 agccttgcaa acccaatgac aatgttcttc gcaaaaaatg gctgaatctc aaaaaaagac 1990381 tgcgggtcag ccagctccct aatcaccttc cgaacatcat aaggctttgt cgtatcagca 1990441 gggacaagac ggtttaataa cggtctggac gcctctttct ctggcttcgg ctctgttgtc 1990501 cggccattca gcggcaaata agacagtagt tttctcaccc ctgtcagaac ctccttctcc 1990561 gtatgcccgg aaaagtgggc gtttccgctg acggcattat gtatccccgc tccgcctaag 1990621 ctctccgcat caacctgttc ccctgtcact ttttcaatca ccttcgggcc ggtaataaac 1990681 atccggccag tctgttcagc cataaatata aaatctgtga gtgccggaga atatacagcg 1990741 cctccagcgc acggccctaa aataaccgat atttgcggaa tgactccgga atataagacg 1990801 tttcggtaaa atatgtgacc gtatccatct aatgataaca caccctcttg aattctcgca 1990861 ccacctgagt cattcagccc gataatcggc gccttatttt ttgctgccag atccatcaaa 1990921 gcgcagattt tcctggcatg ggtttcgcca agcgcccctc cgtacactgt gaagtcttgc 1990981 gcaaatacat aaactgagcg accgtcaatt gtgccgtacc ctgtcacgac cccatcccct 1991041 aacatgcgct gttctcttgt taacacttga ctttccatga aggggtgtaa ttcgataaag 1991101 ctgtcctgat ctagaagaaa tatgatcctt tcccgagcag tgagcttgcc cttttgccgc 1991161 tgctgagcca gcttttcccg tcctccgcct tcttctgcct gcttgcgttt cgtgtaaaaa 1991221 tgatccatgt gctcattcat gctcattgtg ttggtctcct ttcggttcac aaagctctac 1991281 aagaacaccg tttgtttccc gaggggaaat aaacgcgatc tttttcccgt tcgctccctg 1991341 tcttggaaac ctgtcaatca attgaacatg ctgatcagac aatgcttgaa gctgttcaga 1991401 taggcagttg cacaaaaacg caatatgatg cagtccctgc cctttcttct ccaaaaataa 1991461 atggacgggg ctgtcagctg tcaacggctc tatcagctca agtttgacgc taccagcttg 1991521 aaaaaaagca acattcacct tttgctcttc aaccgtttct tgatgaagaa atgcaagccc 1991581 caatacattt tcataaaagc ttcttgcatc ttttatcgaa aaaacggcta tcccgatatg 1991641 gtcaagcctg ttcattttca tccctgcttt cgctaataga tatcgcttgt ccgcccattc 1991701 aaaacacgct aaaatataga cagattgttt aaggagtgaa aatcatgtct caaaaactga 1991761 tgaaaagcgt tttgatcgtg attttgggag tttttattct ttcaactgta ctctcaggaa 1991821 tcgtcatgtt tctataacga taaaaaagca ggcgccttat tcaatgggaa tatcctgctt 1991881 ttttatcaga gctttatgct cgatggcaat ctcctcaaaa gagcggttgt cgtccgtgat 1991941 cagcactctc gttcctactg gtatcgtttg aaacaaatga acaacctcat cgttatgcat 1992001 acgtatacag ccgttagaca caaattttcc tactgattcc tctcggtttg tcccatgaat 1992061 tccataaatc cgcccgtccg ttcctttcgc gtcaaatccg atccatcttg ccccaagcgg 1992121 gttatcagga gatccccctt caatattttt ctttctgtag taaggatttt ccgcttttac 1992181 cgttaccgaa aactctcctt caggcgtcaa atcatctgtt tttccagtcg ccacactata 1992241 cacgccttct actttgttgt cgaggataac agcaagttca tttgttcgct tgttgacaat 1992301 aacatacgga tcacccggca gcggattttc gccgagcggc caaatcggtg aaatcatcat 1992361 gaaaatcgaa cataagaaaa aacgcataag ctcctccttt ttcattaggt tgaccaatga 1992421 aggaagagct catgcgaatc atccgagtga tttttgcgct tttattcctt taaaataact 1992481 tttaatcact aaatattgtt ccatttcgcc gagaagatgg aagagagcgg ccctcgcttc 1992541 aaattcctct ctagtcgcag gaagcggcat ctcctcaaat tcttttctca tgtcagcaag 1992601 tcttttcaga aatttgtatg ctgtattccc agggtgtatc gcctcccgca aatcatgaat 1992661 aaattcagcg atcatttttc cctgatctac cgtgatggag atcgatgtca ctttagggag 1992721 aaggcgttcg ataatttcaa attgcttttc tctcatttta aaataatgat aatgcagatt 1992781 ttcataacgc aaaatgtggt tttgcacatc tcgatatgcc aggtttttag cctccgtaat 1992841 gagctggtgc gtttccggaa tttcttttcc tgaccaatct tgctcaccag ttaacaaata 1992901 ccgttcgatt tctgcaaaaa tgacagcaaa gttatcctct atctttttgc ggtaggcaat 1992961 cagtttccgg tcaagactag gcatatacaa gttcatcaat agagcgacgc cgatgccaac 1993021 cgtaatcagc tgaacttcat tccagatgaa agtaggcgta atgccgccgg acatgtataa 1993081 atgaaggata ataacagaac tggtgacgat accctcgtta atttttaaca gaaccgttat 1993141 cggaatgaat atcaaaagaa gcgctccgat cacaaacggg tggtagccaa taagctcgaa 1993201 aaagagataa gaaaaagcaa ttgccagaca gcatgccgaa aagcgggccc atgaggcctg 1993261 aagcgaccgt ttttgtgtga tttgtatgca caaaatggtg atgattcctg ctgatgcgaa 1993321 gttttgcaaa tgcaataact ggcttatata aatagccaaa gctgttccaa gcgcggtctt 1993381 tattgtgcgg taaccaattt taaacatgtc ggactccatt tctatttgtt tcttcaataa 1993441 aaaagaagag gcggccagcc ttcttctttt ttatattcta taatattttc tctaaaaagt 1993501 cctgcgctct tttggatttt ggcgacataa aaaattcctt cggattgccg tcttcgacaa 1993561 tcattccttg gtccataaac agcacacggt ctgccacttc ttttgcgaag cccatttcat 1993621 gtgtgacaat caccatggtc atgccggttt cgaccagctc tttcatcacc tgtagcactt 1993681 ctttgaccat ctctggatca agggcggagg tcggctcgtc aaacagcatg atgtccggat 1993741 tcatcgcaag agccctggca atcgcgacac gctgtttttg tccgccagac aaacggtttg 1993801 gatagtcatt tcgcttttca aacaaaccga ctttgcggag caggtcctca gctttctcct 1993861 gtgcagcctg ttttgattct ttttttacat tgacaggcgc gtacatgatg ttttcgagaa 1993921 ccgttttgtg cggaaagaga tgaaaatgct gaaaaaccat cccgatgttt tcccggacct 1993981 ttaatgtgtt ggttttcggc ttcgtaatct ctgtgtcttt tattgtaatg gttccgccgt 1994041 taggcttttc caacaggttt aaacagcgta agaacgttga tttgcctgag cctgaaggac 1994101 cgatcacggc aacaacctca ccctcagcga ttgttgttga aatgtttttt aatacttcgt 1994161 gtttcccaaa tgattttgac agcttttcaa ccttaatcat tggatttcag cttcctttct 1994221 acagccttgc cgataaacgt taaaatcagg acaagcacat aataaatcaa tcccgcgata 1994281 atgagcggct caaggtaatt gtaagtggcg gcgccagctt gatatgcgcg tctcatgaca 1994341 tcaccaagcc cgatgacggt gacgatcgcc gattcttttg ttaacgtaat taattcattc 1994401 acaattgcag gtgatatatt tttgaaggcc tgcggcagca gcagatcctt catcattttt 1994461 ccatacggga caccgagtgc aacagcagct tctttttgcc ctttatcaat ggcattgatt 1994521 ccggctctga taatttccga tacataagcg gcggaattca aagacaatgc gacaaccgca 1994581 gcccaaaact ggtcaatttg aaatccgagc agctgaggaa ggccaaaata gacaatcata 1994641 agctgcagca ctaaaggcgt gcctcggaac actgatgtat aaaaatcagc gatccagata 1994701 aacgggcgga atgtgctgat cttgcataag cttagcacaa taccgagtat aagtccgata 1994761 atagcagata caacaacaat ttttaatgta attgccaagc cttctaatat aaaaggaatt 1994821 tgggggatcg ttgctgaaaa atccaaattc atagcctttg tctccttttc ttacaggaaa 1994881 aaagtttcct attcaataaa aaggctcaac gaaaaagttg agccgctttt ttttacttct 1994941 cgccagtgaa ccattttttc ttcaatttct caagctctcc gttatcttcc atttccttga 1995001 gcgctttatt gaatttgtct gtcagttcac tgtcctttct gaaagcaatt gctgaaccgg 1995061 cttcttccgc tttcgcatca ggaatcacaa agccttgcag gtcatcattt gatttgaaat 1995121 acccttctgc aacaatgtct tcaataatcg cggcatcgaa gcggtcagat ttgatttcct 1995181 gcaccaaatc agaaattctg ttgcggtctt ctgttttaaa accatattcc ggagaaagct 1995241 ctttcccctt ctcttcctga atagagccaa gctgaacgcc aactgttttt cctttcaggt 1995301 ctttcaaaga ttgaatgccg ctgtcttttt tgctgacaat catatggttc gctgtgtaat 1995361 acacatcgga aaaatcaact tgttttttac gctcaggcgt tggtgtcatt cctgacagaa 1995421 cgagatccac ctgttttgat ttaagcgctg taattaagct gttgaagtcc atatcctgca 1995481 cttcaatttc atagcctgcc ttctttgcca gagcttttgc cagctctaca tcaaagccga 1995541 caatattatc tccttcttta tattcaaacg gtttgtaatc cgccgaagta cccataatta 1995601 attttttctt tccgctttct gaacctgaat tgcttgagcc gcacgcagtt aatgcaaagg 1995661 tgatgcaagc agccacaagt aataagagcc attttttcat gatccatttc ccccgtattc 1995721 attacttttg gtgtatttga atatttattc gttaatttgt attttaaaca gtttctcatt 1995781 tttatgcaat actattttta aaaattatct ttaggcttat ctttccagtg atctcttctg 1995841 atattactag ataaaaatta aatcgctgta caatccgatt gaataatccc ttaatattta 1995901 ttcatatatc cttggaaatt tatgcacaaa aaaacccggg ctgctttgag catccgggtt 1995961 gttcgtctta tacttcttca caatattctt caaaggcttc ctgcagcttt gccactacag 1996021 ccatcggctc atggccttca atttcatgac gctctaccat tttcatgatc tttccgtctt 1996081 tcaaaatcgc aaaggacgga gaagatggtg gataaccttc aaaatagtca cgcgcacgcg 1996141 ctgtcgcttc tttatcctgt ccggcaaaaa cggtgacgag ctgatcaggt cttttatcat 1996201 agtgaacgga atggtaggct gccggtcttg caattcctcc ggcgcatccg caaacagagt 1996261 ttaccatgac gagcgtcgtt ccttttttcg taagtgcctc atccacctct tcggctgttt 1996321 taagctcggt gtatccggca gctgttattt cttgtctcgc ttggcggaca atatcattca 1996381 taaataaatt aaagtccatg ttcaatgaag acctctcctt tttcatcatc tgttcttatg 1996441 atagcaagga aacgtccata tcggcaaatg actttgcttc gccgtgcact ttttttgctc 1996501 ttcgtttact gcttacagaa aaaggggatt atataaccag aagtaaaata aaggagcagt 1996561 tgtatatgag ccaccggaaa gcgttactga ttcataacgg aaatgccggc aacaaaaata 1996621 tagaaaaagc acttggtgct gtggtgccgg ttttatctca ccatttagat gaggtgatta 1996681 ttaaacagac aaagaaaaag gatgatgcgt atcatttttg ccgatccatt gatgattctg 1996741 tcgacaccgt cttcattctc ggcggcgacg gcacgatcca tcaatgcata aatgctatca 1996801 gcgctctaga aagaaaaccc gctgtcggaa ttttgcccgg cggcacgtgc aacgactttt 1996861 caagagtgct tggcatccct caaaatcttg caaaggccgc ggaagcactt atggcgggaa 1996921 aaaaaaccag cgtagacgta tgtcagatga atgaccgtta ttttttgaat ttctggggga 1996981 tcggcttaat tgcagaaacg tcgaatcaaa tcaacgaaac ggaaaaagca ttattgggaa 1997041 aaatcagcta ttttacaagt gccttgcgaa ccgtctcatc tgctgcatcg tttccgatga 1997101 cattaaaaat tgatggagaa gaaattaaag aagaagccgt tatgctgctt gtgatgaatg 1997161 gccaatacat tggaacgaat cgaattcctc tgcccgatgc cagtattgaa gacggcttac 1997221 ttgatgttct catatgccgc aataccaacc tcaccgcgct gcgggagctg atgagcatgg 1997281 aacaaggctc aattgatcgt tttactggag agttgtccta tgtccaggct tcccgtatcg 1997341 agattgaaac agacactgcc aaaaaggcgg atatggatgg agaagtttat acacatacac 1997401 ccgcagtcat tcaggtcctg ccacagcata tcgacatgct tgttcccgca aatgaataac 1997461 tgtcataagg ctttagaaag attttgcaaa tccgttgact ctcccctagg aggaggtctt 1997521 acagtataag ggatacacac ttgaaaaagg ggaagtcata tggagaagaa aaatattacc 1997581 ttaactatat tattaaccaa tttatttatt gcttttttgg ggatcgggct tgtgattcca 1997641 gtaacgccga ccattatgaa tgaattgcat ttatcgggga ccgcggtcgg ctatatggtt 1997701 gcctgcttcg ctattacaca gctcattgtc tcaccaatag ccggacgatg ggttgatcgc 1997761 ttcgggcgca agatcatgat cgtaatcggc ctgttgttct ttagtgtgtc ggagtttttg 1997821 ttcggcattg gaaaaacagt tgagatgtta tttatctccc gtatgctggg cggtatcagc 1997881 gcagccttca ttatgcccgg ggtcacggct tttattgcag atatcacgac cattaaaaca 1997941 cggccaaaag cgctcggtta tatgtcagcc gctatttcaa caggatttat tatcggcccc 1998001 ggcatcgggg gatttttagc agaagtccat tcccggctgc cttttttctt tgcggcagct 1998061 tttgcactgt tagcagccat tttatcaatc ctcacgctgc gcgagccgga acgaaaccct 1998121 gaaaatcagg aaataaaagg acagaagaca ggctttaaac gaatttttgc ccccatgtat 1998181 ttcatagctt ttctcattat cttaatttcg tcttttggtt tagcatcatt tgaatcttta 1998241 tttgcattat tcgtggatca taaattcgga tttacggcca gcgacattgc cattatgatt 1998301 acaggaggag cgattgttgg cgccattacg caagtcgtct tattcgaccg cttcacaaga 1998361 tggtttggcg aaattcattt aattcggtac agcttaattc tctcgacgag tctggtattc 1998421 ttgctgacaa cggtacattc atatgttgcg attctgctgg tgacagtcac cgtatttgtc 1998481 ggatttgatc tcatgcggcc tgcggtaacg acttacctgt caaagattgc gggaaatgaa 1998541 caggggtttg ccggcggtat gaattcaatg tttacaagta tcggcaatgt attcgggcct 1998601 attatcggcg gaatgctgtt cgatatagat gtaaactatc ctttctactt tgcaacggtc 1998661 accttagcca tagggattgc actgaccatt gcttggaaag cgcctgcaca tcttaaagcc 1998721 agcacgtgat aagaagcgca ttctttgtgt actgcaaaga atgcgcttct tctttatact 1998781 gatgatagaa ggagtgatgg catgaaggaa tcgtattact caattgggga agtatcaaaa 1998841 ctggcaaacg tgtcgataaa agcgctccgt tattacgata aaattgattt atttaaacca 1998901 gcctacgtcg acccggatac cagctaccgc tattatacag attctcagct cattcatctg 1998961 gatttgatca aatcattgaa atatatcggc acacctttag aagagatgaa aaaagcacag 1999021 gacttagaga tggaagaact gtttgctttt tatacagagc aggagaggca aatcagggag 1999081 aaattagact ttttatcagc cctggagcaa accatttcat tggtgaaaaa gcggatgaaa 1999141 cggcagatgg aatatcccgc gctcggtgag gtgtttgttt tagatgaaga agaaatacgg 1999201 atcattcaga cagaggcaga aggaatcggg cctgaaaacg tgctcaacgc ctcctacagc 1999261 aaattaaaaa aatttatcga gtcagcagat ggatttacga acaatagcta cggcgctact 1999321 ttctcttttc agccctacac cagcattgat gaaatgactt accgtcatat tttcacacct 1999381 gtattgacga ataaacagat ttcatcaatt acgccggata tggaaatcac aacgatccct 1999441 aaagggaggt atgcgtgtat cgcgtataat ttttcgcctg aacattattt tctcaactta 1999501 cagaagctta tcaaatatat cgcggaccgc caattaacag ttgtcagtga tgtatacgag 1999561 ttaatcatac cgattcatta ctccccgaaa aaacaagaag aatatcgagt cgaaatgaaa 1999621 atacggatcg ctgaataata aagcatagaa aaagagcatt ttttgaaaca aaacttcaaa 1999681 aaatgctctt tttgcttatt tagtaaacag atgtcttctc gtcaatcgat tctaaaattt 1999741 gtttcactcg tccgaggaat cgtccgcaca cgagaccgtc aagcactctg tgatctaatg 1999801 acaggcacag attaaccatg tctctgacag caatcatgcc attgtccatg acaaccgggc 1999861 gtttgacgat ggattctact tgaagaatcg cagcctgagg gtagttgata atgcccatcg 1999921 actgaacaga cccgaacgaa cctgtgttgt tgacggtaaa cgtgcctccc tgcatgtcat 1999981 ctgcagtgag ttttccgtct cttacttttt tagctaggcc ggtaatgtct ttcgcaatgc 2000041 ctttaattgt tttttcatca gcgtttttaa tcaccggaac aaataaagaa tcctctgtgg 2000101 caactgcaat tgaaatattg atatcctttt tctgaataat tttgtccccc gcccacatgc 2000161 tattcatttg cgggaattct tttaacgcct gagcgaccgc ttttacaaaa aaggcgaaga 2000221 acgttaaatt aaagccttct gtcttcttaa aagaatcttt tatactgttg cgatatgcaa 2000281 ccatatttgt gacgtcgact tccatcatcg tccaagcatg cggaatttct gttttgcttc 2000341 gcttcatatt ggaagcaatt gcttttctta cacctgtgac agggatttct ttatcaccgg 2000401 ctgcagacgc aggatatgac gtctcttctt ttggctcagg ttttgatgca gacttcggtg 2000461 caggagctgc tgttttcagc tcctcaggat tctgttcttg cacgccgcct gtttcaatta 2000521 agcgctgaat atcttttcgt gtgatgcgcc cgccggcacc agttcctgtc acttgatcga 2000581 ggtcaatgcc gtgctctccg gccaaacgga gaacagctgg cgagtagcgc tttttattgg 2000641 gctgatcggc tgctccagca ctttttgcaa cagggttctc agcggcttct gatgctgctg 2000701 gctgttcttg tttttgttca gccggattcg cgccttctgt ttcaattttg caaatcattt 2000761 ctccgacttg cagggtttgg ccttcttctc ccacaagctc tgttatcgta ccagtaaaag 2000821 aagacggaac ctctgcattt accttatctg tcatgacttc cgcgatcgga tcgtatttgt 2000881 tcactttatc accgggggcg acaagccatt tgctgatcgt cccctctgtt acgctttctc 2000941 caagctgcgg catcgtcatt tgttcaattg ccatgattgt atcctccctt acgtctttaa 2001001 aactccgcta attctctcat cgccgcttcc actttatcag ggttgaccat aaagtatttt 2001061 tccattgtcg gcgcataagg catagccgga atatcaggac ctgcaagccg tttgatcggc 2001121 gcgtctaagt cgaacagaca atgctcggat ataattgcgg ctacttcgct catgatgctg 2001181 ccttcttttg tatcttctgt gaccaaaaga acctttccag ttttggacgc agcttcgatg 2001241 atggcttctt tatcaagcgg gtaaactgtt cttaaatcca ccacatgcgc tgaaatgcca 2001301 tctttttcga gacgttctgc agcttgtaag gcgaagtgga cacacaggcc gtatgtgatc 2001361 actgtgatgt cgtcgccttc cctttttacg tccgccttgc cgattggcag gacataatca 2001421 tcagccggaa cctcgccctt tatcagacgg tatgcccgct tgtgctcaaa aaacagcacg 2001481 gggtcttcgt cacgaactgc ggcttttaag agccctttcg cgtcatatgg tgttgatggc 2001541 atgacaattt tcagtccggg ctggttggcg aaaattgctt cgactgattg agaatgatac 2001601 agggctccgt gcacgcctcc gccgtatggc gctctgacga caatcggaca gctccagtca 2001661 ttgttgctgc ggtagcggat tttagccgct tcagaaataa tttggttgac tgccggcata 2001721 atgaaatcag caaactgcat ttcagcaatc ggtctcattc cgtacattgc cgctccgata 2001781 ccgactcctg cgattgcaga ttcagcaagc ggcgtatcca taacgcgctc ttccccaaat 2001841 tgttcataga gtcccgctgt cgctttaaac acaccgcctt ttcttcctac atcttcccca 2001901 aggacgaaaa cgcgagaatc tcgttccatt tcttctttca tcgccaaatt gattgcatca 2001961 atatatgaca ttactgacat ttgttcttcc tccctacttc gcataaacat aatcaagcgc 2002021 tgactcagga gctgcatatg gggcgttctc cgcttcatcc gtcgcttcat ttacgattgc 2002081 cataatttca tccagcatgg tttgttctat ctcatcggac agcaggcctg tttcctttaa 2002141 gtaagcttga taagtaagca ggggatcact ttttttcgct tcctctactt cttcacggcc 2002201 tctgtagctg ctgtcatcgt catcactgga atgtggtgta aggcggtaag aaatcgtttc 2002261 aattaatgtc gggccttctc ctctgcgtgc cctttcgcgt gcttctttaa ccgcttgata 2002321 aacttccagc ggatcatttc cattcacagt tacgccaggc atcccatagc ctatggcacg 2002381 gtcggaaatg ttctcacatg cgacttgctt atcgtaaggc actgagattg cgtatttgtt 2002441 gttttcacac atgaaaataa ccggcagctt atggacagcg gcaaagtttg ccccttcatg 2002501 gaaatcgcct tggtttgaag acccttcccc gaatgtaaca aaggctgcga tatccttttt 2002561 ctccatacgt cccgcaagcg caataccgac tgcgtgcggc acttgcgttg taaccggaga 2002621 tgatcccgtc acaatgcggt ttttcttttg tccgaaatgt cccggcatct ggcggcctcc 2002681 tgagttcgga tctgctgctt ttgcaaaccc ggacatcatt aagtcctttg ctgtcatgcc 2002741 aaacgcgagc acgacaccca tgtctctgta gtacggcaat acataatcca tttcacggtc 2002801 aagtgcgaaa gccgctccta cctgtgctgc ttcctgtcct tgacaagaga ttacaaatgg 2002861 aattttgcca gaacggttta acagccacat tctttcatcg atttttcttg ctaacagcat 2002921 ggttctatac atatcaacgg cttcctgatc agtcagccct agtgcttgat gtcggtttgt 2002981 actcattcaa gcccctcctt tatgctttta aaaatgaatg gctttgccat ctgcggcaag 2003041 cgcagcttct ccaattgctt cagaaagcgt tggatgcggg tgaatcgttt gcccgacctc 2003101 ccacggtgtt gcgtccagca ctttggcaag acccgcttca gaaatcatgt cggtgacatg 2003161 cgggccaatc atatgaacgc cgagaatatc atctgtatct cggtcagcca cgattttgac 2003221 aaaaccgtcg ctttcaccgt atacaagcgc ttttccaatc gccataaatg ggaacttgcc 2003281 gattttgaca ttatgcccgt tcgcctttgc ttcgtcttcg gttaagccga cactggcagc 2003341 ttcagggctt gagtaaatgc acttcggcac aagcgtcgga tcaagcggat gcggattgag 2003401 acctgcaaaa tgctcaacag caataattcc ctcatgtgaa gcaacgtgag ctaactgcag 2003461 gccaccgatt acgtctccga ttgcataaat atgagattcc ttcgtttggc agctttcatt 2003521 gactgaaatc atgccatttt cagtaacaat atcggtgttc tctaggccga tgccttcgat 2003581 atttgcctgt ctgccgatgg aaacaagcat tttctcagca gaataggtaa cggtttctcc 2003641 gtctttttcc gcttgtatgc tgatatcgtc tgatgttttt gtcattgtgt caggcagcac 2003701 ttttgcccct gttatgaact ggatgccttt tttcttaaga agactttcca tttcttttga 2003761 aatctctaga tcttcagtcg gcaatatgcg atccgcgtat tcaataaccg ttaccttaac 2003821 gccaaaatca tgaagcatag acgcccattc gataccgata acccctccgc cgacaatgat 2003881 gattgactgt ggcagctcct ccatttggag cgcctcatct gaagtcagta cagacttacc 2003941 gtccacttca agacccggaa gcattctcgg tcttgatcct gttgcaatga tcacttgttt 2004001 cgggatcagc atgtcatttt cttcgccatt tccccgctca acagaaattg ttcccggcag 2004061 cggagagaag attgacggtc caaggatacg tccatatccg gtgtacacgt caatttttcc 2004121 ttttttcatt aaatgattta cacccgctgc aagcttatca acaacggctt gcttacgctg 2004181 ctgcactttt tcaaagttga gggacacgcc agccgtttcc actccgaatt gatcggcttc 2004241 acgagctgtc cggtatacct ctgcgcttct aagcagcgct ttactcggga tacagccttt 2004301 atgcagacat gttcccccga gtttttcctt ttccacaacg gctgttttta agccgagctg 2004361 agcggctctg atggccgcaa cataaccgcc ggtaccgccg cccagaatga ctacgtcata 2004421 ctcagttgcc atggtgactc actcctgtct gtctattcaa tacgatattg tttggattgc 2004481 tcttcgccct gcaatactct tagcgcccct tgggcaagag actgcagttc attttcaccc 2004541 ggataaacta aaacgtctga aatccaatct atgtatgatc tgatagcaga aacaaagctt 2004601 tttccgtacg caaggcctcc cgtcagcaca atcgcttcaa cttcgccttt taacgccgcg 2004661 ctggctgccc cgatttcctt tgctacctga tatgccatgg catcataaat gaagcgggct 2004721 ttttcatcgc ccccttgaat catctgttcc acttttactg catcatttgt accgagatag 2004781 cctaaaagtc cgccggtgcc aacaagcttt ttcatgattt cttcttttgt atattcccct 2004841 gaaaaacata gatcaacaag atctcccgca ggcactgttc ctgctcgttc aggactgaat 2004901 ggtccctcgc cgtgcaggcc gttattgaca tccaccactc gcccgcggtc atggacgcca 2004961 attgtaatac ctccgcccat atgggtaata atcattttca tgttctcata tcgtttgcca 2005021 agggaggctg ccgctttacg agcgacagct ttttggttta acgcatggaa aatgcttttc 2005081 ctttcaattt caggcatgcc tgaaactttc gcaagcactg acatttcgtc tacgacaaca 2005141 gggtcgacga tatacgaagg gatattcagg ccgtcagcga tttcccgcgc gataatgccg 2005201 ccgagattag aagcatgctg accggcgtag ccgcttttca aatcctcaat catctcatca 2005261 ttcactacgt aggtcccgcc ttcaattggc cggagaaggc cgcctcttgc gcagactgca 2005321 tcaaactttg aaatattgat tccctgttca tgaagcgttt cgagaatatg gtttttacga 2005381 aattcatact gatcaataat tcggtcaaat cgctgcagct cttctatgtt gtgtctcaat 2005441 gttttttcaa aaatgcttct ttcgttatga aaaacaccga ttttcgttga agttgagcct 2005501 ggattaattg tgagaatgcg tttttcgtca tgtagcactt tcataacctc cagatcaatt 2005561 tcttaacgtc tgcttaatac actgtggccg ttttgcaaaa actggcttct tgagcggcgc 2005621 atgcgttcaa tccgttcctc tgctaagcgg tcagccgcta aatatgcagg aatgccgtca 2005681 cgctgagaaa tctcaagtac acgctcgata ttgccgtaaa tgccttcaac ttttttcaat 2005741 gcacgttctg cattatagcc gtaaagctca tctgccacgt tgatgacacc gcccgcgtta 2005801 atcacgtaat ccggtgcata aacgatgccc atttcgtgaa tttgatcacc atggcgtgtc 2005861 tcttttaatt ggttgttagc cgcacctgcg atcactttcg ccttcagctg tttaatggtg 2005921 tcgtcgttaa tagtcgcacc aagggcacac ggcgcataaa tatcgcagtc ttgtgaataa 2005981 atgtcatcag gatctaccgc acgggcgcca aaatcttcaa ctgcacgctg tacagattgt 2006041 ttgttgatat ccgtaacgat taagtttgct ccttcttcat gcaggtggcg gcaaaggtta 2006101 taggctacgt tcccaacacc ctgtacagca atggtttttc cttcaagaga gtcggttccg 2006161 aaagcagctt tagctgctgc cttcattcct ctgtacaccc cgtacgctgt gactggggac 2006221 ggatttccag aagagccgaa agcaggagaa atccctgtga catagtctgt ctcatcatga 2006281 atgatatcca tatcctcgac cgttgtgccc acatcttcag ccgtgatgta tctgccattc 2006341 agtccttgaa tatagcggcc aaacgcgcgg aacatttcct catttttgtc tttgcgcgga 2006401 tcgccgataa tgactgtttt tccgccgcca aggtttaagc ctgccgccgc gttcttatag 2006461 gtcatgcctc ttgccaatct gagcgcatct tcaattgccg cttcttcatt ttcatatgtc 2006521 cacattctcg ttccgccaag cgccggacca agcgttgtat catgaatggc gataatcgct 2006581 tttaatccag attgttcatc ctggcagaat accaattgtt cgtaatcgta tttctccata 2006641 tatttaaaaa gttccatgtt cgttcctcct aatgtgtgta ttcttcagat gcgcatattg 2006701 ccagcgcaat ggaatacagt ttattttcag cagagtccgc tctgcttgtt aaagcaatcg 2006761 gtgcttttgc tcctgtaatg acagccgcca cgctggcctt ggcaaaataa atcagtgatt 2006821 tatataaaat attgccggcc tcaattgttg ggacgagaag gatatctgcg ttgcccgcta 2006881 cgtctcccga aatttttttc tgggccgcgg caatttgtga aactgcgtta tccaaagcaa 2006941 gcggtccatc aacaatgcag cctttgatct ggcccctttt gtacatttga gctagagcag 2007001 ctgcattcac ggtcgcttcc attttagggt tcaccgtttc gaccgctgca agggcagctg 2007061 cttttggcat attgttcccc actgcatggg ccacatgaac ggcattttgc aaaatctgcc 2007121 ggagctcttc cagcgaagga gcaatattca ttgccgaatc tgtcacaaac atcagccggt 2007181 caaaatccgg tatatcgaag acagccacgt gagaaaggac acttgctgac cgaagcccct 2007241 cctgtctgtt caataccgct ttaagcaaaa cagaagtcgg cacattgcct ttcattaaaa 2007301 cgtccgctgt tttatgatgc acagcacgaa ccgctaattt cgccgattcc tcaggagtat 2007361 tggcatggac gatttccact tgatgccctt gcatggatga tgtcagctcg ttcagttttt 2007421 tgctgtcgcc cgttaacaag aaacgggcgg ataggtgctc ggctgccagc tttacagccc 2007481 ggatcacttc ctcatcctca gcatgagcaa ccgcaatggt cttatttttg tgtatcgacg 2007541 ctttgccgat taaatctttc agcttcatct gttaccacct ttcttgtttc gactccgcct 2007601 tttattatgc aagttccatg ccagctctta agggtgctgt cataccaggt ataccgaaac 2007661 attcgtgcag atgtttgcgt ttattctgca aattattgca tgccttcatt tgcaaggcca 2007721 tatttatcca ttttgtaata taaattccga atgctgacac cgagagcttt tgctgttttt 2007781 gtccggttaa aatgatgctt ttcaagcgtt tgctggatca aatgcgcttc aaatttttct 2007841 actgcgacag acagcttttc gccttcaata tccggaaaat caaaacctgt tccctgatct 2007901 gtgtcatttt ctttttgctc aagttcgaat acaggcaagt gatctttttc aatccattcc 2007961 atatgcggat tcagaaaaat catggctcgt ccaaggacat tttcaagctc ccggacattc 2008021 ccaggccaat ggtaggcaga taaggcgcgc aaggcttgct gtgagagccc ttttacattc 2008081 ctgccgtaat cccggttgat cttttggata agtctgacgc tcaatgcttc aatgtcctcc 2008141 aaccgctgcc gcaaaggcgg gatggagatc ggatagcgat tgatccggta atacaggtct 2008201 tcccggaatg ttccgtccgc catcgccttt tcaatattta catttgtcgc cgcgatcact 2008261 ctgacgttga cagggatcgc tttcgtgccg cccactctga cgatttcctt ttcttgaagg 2008321 acgcgtagca atttggcctg catattttgt gtcagctcac cgatttcatc taagaaaata 2008381 ctgccgttat ttgcttcctc aaataaaccc tttttaccgc cgcgcttcgc tcctgaaaac 2008441 gcaccatcct catagccgaa caattctgat tcgagcaggt tttcagaaag ggctgcacaa 2008501 ttcacgcgaa taaatttatt gtatttccgg tcactttcgt tatggatggc atgggcgaac 2008561 agttcttttc ctgttcctga ttccccgcgc agcaagatgg ttgccggtgt tttcgcaccg 2008621 agcttcgcct gctcaagcgc aaccagcatt tgctcgcttt tgccgataat gtcgtcaaac 2008681 gtgtatttcg cttcaagcgt gcgaataatt tgtctggcgc gattaagctc cgctgtcagc 2008741 attttaattt cggaaacatc gtgaatcacg ccgacgctgc ctttcaaaat cccgtccaca 2008801 atcaccggtg ctacattaac gatcacttct ttttcattcg ggccgacctt cattctgaca 2008861 ccgcggacag gacgtcttgt ttcaagcacc tttaaatgca tgctttcgcc ttcggaaata 2008921 tcagtgtttg caggcttgcc gatgacttct ttttcagaaa gccccgtcat tttcgtatac 2008981 gctttattga ttagcaggcc gatgccgttt tcatcaacga cagaaatcgc ctcatcggag 2009041 gattgaataa ttgcctccag catcgtacgg acctgcttta agttggtcac ttcctctgcc 2009101 agctcgaccg catcagtgat atctttaaac acacaaagag ccccgagcag acgtccgcct 2009161 tcatcaataa tcggcagtct tgtggtcaca atttgcaaat gatcgcctaa cagctgcttc 2009221 tggttgtatt caggcactct tgtttttaaa atccgcggca tcttagtgct cggaatcact 2009281 tcttttattg ggcgcccaat gacttcctca cgtttttttc cgaccatttt ttcggccata 2009341 tggttaaaga gaatgatttc ttcattgata tcaataaaaa tcattccatc atgggtggaa 2009401 ttaaaaattc tgtcatattt ataggtttgc tcttttagca tttgaatcag gtgctgcttt 2009461 tcttccatca gctgaaaaac gatgtatgcc atttttcccg gcatgacaat ggtatcttca 2009521 tgctttcttt gaaggagctc gtcaaacacg gcttgatcgc cggtagtatg aatgacgata 2009581 tccggttttt gttgtatgta aggtttccaa tcagatgata cggcaatccc atactgttct 2009641 gcttctttca atcccggcgc ctcggggtct ttgtcaacta cggcaatgat atctatgatg 2009701 gctgttttaa tcagaatatg taataacgcc gttccccttt tgccggcacc tactatcagt 2009761 accttttgca tcccgatacc cctttgtatg aaaaaatttg cacacctatt tattccgttg 2009821 caataatttg cacaacccta tgttaccacg ttttcttctc ttgacaaaat attttttccg 2009881 ctggacaata aaggaaatga aaagataaag gggttttctg aagatgagcc gacttcttgc 2009941 gcttttaata ttagtcatcc ccggggctat ttctgcttta ggcattaaac tgatgagaga 2010001 tacacttttc ggccatacaa tcaagccatt ttcagctctt tggctccaag ggttgtcagg 2010061 attcatcttt tttgcgatcg gcctctatgt gctggccggg ttcattttat acagagacag 2010121 aaaacgcaat caagtcagcc cgcgattcag aaaacgatag ctgaaaaaaa gccggagaat 2010181 gctccggctt tttttgttgc attattcgtc aggcaaaacg gtcttggcaa tcgttttgtc 2010241 taacgcttca tagtcataat aagaaatcgt atcgtacagt tcttttcgtg tctgcatatc 2010301 atgaagtcct tctttttgtg agccgtgctc cttcatcaaa ccaaacatcc gctcacaagc 2010361 ttttgccgcc gctcgaagcg aggtgacagg atatatcacc atgtgaaacc ccatatcttc 2010421 gaattcatcg gcacgataat atggcgtttt cccaaattca gtcatattcg caaggagcgg 2010481 aacggggata cgctcagcaa actggcggaa ttcattctcc gcctgtagcg cttccgggaa 2010541 aattgcgtcc gctcccgcct caatgtaagc ctctgaacgt tttattgcgg catcaagccc 2010601 ttcctgcgcc ctggcatcag tacgggcaac aacaataagg gagggtgccg cttgtttaat 2010661 ggcttttatt ttttgcgcca tttcctttat cggaactagc tgtttgccat ttaaatgtcc 2010721 gcattttttt gggagctgct ggtcttccat ttgaacggct gctaccctgg cttcaagcat 2010781 ctcccgggct gttcgggcgg catttaagac accgccaaat cccgtatcga tatccacaag 2010841 caaaggcaga tcagctgcac gcacaagatc tttggcccgt tcagctatct ctgccgatgt 2010901 gatgatccct aaatcaggca gccccctgct ggctgtatag gcagcaccgg acaaataaat 2010961 agcagaaaaa ccggcttctt tcgcaagcaa agcggccatc ccgtcatggg cgccgggaat 2011021 ttgaagaatg tccggtgctg acatcagctt gcggaaacgc ccggcaagct cctcttgtga 2011081 cgattgctta ttgacgatcc acgacatgaa acaaaatccc ccttttacat gcagaacatg 2011141 tctacgaatt catttacgcg catcgtttgt aatgtctcat agctggtaca gcgctcataa 2011201 atgtgtttgt gctgtttatc aggaaaatgg gttttgagat tgtcagaaaa cttttccagc 2011261 agtttcggca ctgcttcctc tcttcgaaaa cgatggccga ggggaaactc acattccacc 2011321 atttccgtgc tcgttccatc tttaaaatga acctgaacgg catttgagat ggagcgttta 2011381 tcaggcttca aataatcctc ggtatatgtt ttattttcag tcacttccat tttatcacga 2011441 agtttatcta ttctcggatc attcgctgtt tcagcttcat aatgctgtgc ggtgatatca 2011501 ccaaaaagca aaccgattgc tgtaatgtat tggaggcagt gatcacggtc tgccggattg 2011561 tggagcgggc cttttttatc aatgattcgg atagctgatt catgcgttct gatgacaact 2011621 cggtcaatct cgtcaatccg gttctttacc tgcgggtgaa gaatgacggc ggactccgcc 2011681 gctgtctggg cgtgaaattc cgcaggataa gacactttaa ataacacatt ttccatgaca 2011741 taagcgtcga gcggacgggc aagcttgatc tctttcttat tgaataaaac gtcttggaac 2011801 ccccaacccg gtgcactcaa ggctgtcgga taacccattt ccccttttaa cgacatcagc 2011861 gccaaatgaa cacctctgct cgttgcatct cctgccgccc atgatttacg cgagcctgta 2011921 ttcggtgaat ggcggtatgt cctcaatgct gcattgtcaa tccatgcatt cgaaagcgca 2011981 tttttgattt cttctcttcc gccgcccaaa agctttgctg caacagcagt tgtcgcaact 2012041 ttgacaaaca gcacatggtc aaggccaact cgatttaagc tgttttctaa cgccagcaca 2012101 ccttggatct cgtgtgcttt gatcatcatc tcaagtacgt cgcgtaccgt taacggctct 2012161 tttccttcag acagcctcac tcttgataca taatcagcag cggcaaggat tcctcccaag 2012221 ttatcggatg gatgccccca ctccgccgcc agccacgtat cgttgtaatc gagccagcga 2012281 atcatgcagc caatattaaa cgctgccctc acaggatcga gaacatatga cgttcccggc 2012341 actttgcttc cattcggcac agtcgttcct ggaacaatcg ggccaagcag ctttgtgcat 2012401 tccggatacc gtagcgccaa gattccgcag cccagggtat ccagcaatac atgccccgct 2012461 gttgtatacg cttcggcact agtaatctct ttctcaagca catagtctgt gatttcttcg 2012521 ataacacgat ccgttttcgg cattctacca gctcctttca tgattttgtt tgatatcgcg 2012581 ggcccatgta actgacacgg ggacggaaga gccgattatt ggcatgctgt tcgatcacat 2012641 gggcgcataa accggacgtt ctcgcgctga aaaagatcgg cgtatataaa ggaatcggta 2012701 tgccgagcat ccaatacact ggggcagcat agtaatccaa attcgggtaa agcccttttt 2012761 ccttctccat cagccgctca cccgcttcgc acatctcata taaacgatgg tcaccggctt 2012821 tatcgcataa ttgctgcagc gcctctttca tcatgagtgc tctcgggtcc atttttttca 2012881 tatacacccg gtggccgaag cccatgattt tttcttttct tttcagtttt gtttgcaaaa 2012941 gctgctcaaa atcagatgtc gtttttgcct ccaaaagcaa atacatcaca gcttcgtttg 2013001 ctcctccgtg aagattccct ttcagggaag cgacagcccc agtcaaagcc ccataaagat 2013061 ctgaatgtgt agatgcaatg accctggccg caaaggttga attcggcatc tcatgctcac 2013121 tgtacaggac gagcgaccgg tcaaaaatct gttcttccaa tgaagacggc aatttccctg 2013181 tcatcatgta gagaaaattc gcactgtagg atagggtttg aagcggaaga atcggttctt 2013241 tcttattaat gatcctgtag ctggcagcag tgagggcagg cattttccca agaagctgat 2013301 aggcgcgttc tttgtttgcg gaaggagacc gatcatcaat ttgccgatca tagccagcaa 2013361 gtgccgacag gccggtacgc agaccatcca ttggatgagt gtcctcaggg agcagctcaa 2013421 gcagacggag atgatcagca ggcaggcttg aggcactgtt tattttacgt tccagcgttt 2013481 ccatttcact ttcttctggc agcctgccct ccagcaataa atggacaagc tccagatagc 2013541 tttttgtttc agaaagttct attaaatcat agcctcttat caaaatctgg ctggactgcg 2013601 tgtcaagata agaaatatga gtttctgccg caatcacacc gtccaaccct ggagaataat 2013661 gctgtttctc ctccatatcc tcaacctccg tttttgcgtt ttttgtctat caggttccgc 2013721 caagcaaata cttggaaata atcagtcttt gaatctcgtt cgtcccttca taaatttgcg 2013781 tcacctttgc atcgcgaagc aggcgctcaa ctggataatc cttcatatag ccatatcccc 2013841 cataaatttg aacggcgtct aacgccgcct ttacggctgc atcggaagca aattgtttag 2013901 ccatagacgc ttcttttcca cagtttaggc cgcggttatg aaggtctgca gcgtggtaga 2013961 caagatgtct tgccgcctca gctctagtcg ccatatcagc cagcttaaat gatatgcctt 2014021 gattggctgc aatcggcctt ccaaattgca ctcgctgctt cgcataatca acggcatgct 2014081 caagagccgc ctctgcaatt ccgagggcct gtgccgcaat gccgatccgg ccgacattta 2014141 aattcgccat ggcaatgtga aagccatccc cctctttgcc aagcaaattg gcttcaggca 2014201 cttctgcatt atcaaaaatc agttccgtag tattggagcc ataaagcccc agctttcttt 2014261 ctttttttcc aacggtaaaa ccgggtgtgt ttttttcaac aataaaagcc gaaatcccgt 2014321 gcctgccttg atctggagct gttaaagcaa atgtgatata gatatcagct gctccgccat 2014381 tcgttatgaa tattttcgat ccgtttaata ggtatttgcc gttctttttg attgctgttg 2014441 tgcggaggct cccggcatcc gaccccgagt gaggctccgt tagtgcaaat gcgcccaaat 2014501 ggtctcctga cgcgagattt ggtatatatt tcatcttctg ttcttcgttg ccgaaataca 2014561 gaatcggatt cgtgccgact gaggtatgaa cggagagaat cacgccgaca gccgcgctga 2014621 ttctagaaat ctcatgaatt gccaaaatat aagaaacaac gtccgctcca gcaccgccgt 2014681 attgttccgg caccggtatt cccatcagtc cgtgtttacc catttttttg atcagctgaa 2014741 agggaaattc gtccgttttc tccatgattt ccgcagcggg agcaatttct tttcgtgcaa 2014801 aatcacgcac catttttcgc atcatgactt gctcttgggt tacatgcaac tcggccaccc 2014861 ccggatggaa tagacttcag gaagtcttct cctcatagtc ataaaaaccg cgtccgctct 2014921 ttttgccaag ccagcctgct ttgacatact tgcggagcag cgggcaagga cggtatttgg 2014981 aatcgccaag gcctgagtga aggacttcca taattgataa acacgtatcc agtccgataa 2015041 aatccgctaa tgcaagcgga cccatcggat gattcatgcc cagcttcatc acttcatcta 2015101 ttgcctccgg cttcgccact ccctcataca cgcaatagat ggcttcatta atcattggaa 2015161 gaagcacacg gttggaaaca aacccaggaa aatcattgac ttctaccgct gttttcccca 2015221 tcttttccgc taatgccata acatctaagg ccgtttcttc tgatgtagcc aagcctcgaa 2015281 tcacttctac cagcttcatt acagggacgg gattcataaa atgcatgcca ataacccgtt 2015341 gaggccggtt tgttacagca gcgatttctg taataggcaa ggaagatgta ttgctggcca 2015401 aaatcgtatg aggcgggcaa atgcgatcaa gtgttttaaa catctcagtt tttgccgcca 2015461 tgttttctgc gatagcctca atcacaatgt ccgcatgctc tgcctcctca agtgtttgag 2015521 aaatcgaaat gcggttgatt acgctcttca cttccgtctc ggtccttttt cctttctcag 2015581 catcacgggc cagctgtttc ttcagccgtt tcaatcctgc ctccgcggcc tctggattca 2015641 catcatacat ccgcacataa aagcccgcgt cggcggctgt ttgagcaatt ccgctcccca 2015701 tctgacctgc gccagctacc atgatttgtt tgatttccat tcaaatcccc tttttcatca 2015761 tgttttaatg aacctgcact aagacggcgt ctccctgtgc tgccccgctg caaatagcgg 2015821 caacgcccag accccctccc cgtcgcttta attcataaac aagcgtcatg agaattctcg 2015881 caccgctcgc gccgatcggg tggccgagcg cgatcgcacc gccattcaca tttacttttt 2015941 caagatcgaa acctacgatt ttttcacatg tcaaaacaac tgaagcaaaa gcttcattta 2016001 cttcaaacaa gtcaatatct tggacagtta aaccattctt tttcaggagc ttgttaatag 2016061 caaaccctgg cgctgccgcc agctcgtgcg ctggcattcc cgtagttgaa aaaccaagaa 2016121 ttgtagccag aggccgtttg ccaagctcag cagctttttc ctcagacatc agcacgaacg 2016181 cgccggctcc gtcattgact ccaggagcat tgccggctgt gatagaaccg tcacttgcat 2016241 aaatcggagc aagttttgcg agctgatcca gacttgtgtc acggcgaatc gcttcatctt 2016301 tatcaacaac gtttggtttt ccttttcgac cgatccagtt gacgggaaca atttcatcct 2016361 gaaacttccc ttcatcggcg gccttagctg cccttgcatg acttctcaac gcccattcgt 2016421 cctgctctct tcgtgagatt gcatattcct tggcagctgt atttccgtga acagccatgt 2016481 gcacctcgtc aaatgcgcac gttaatccgt catacaccat taagtcccta agctcgccgt 2016541 cccccatccg tgctccccag cgcccggcgg gaacggcata cggaatattg ctcatgcttt 2016601 ccatcccccc cgcaacaagt atgtccgcat cctgcgcccg aatcatttga tcacataaag 2016661 tgacagcgcg aaggccggaa gcacagactt tattcagtgt ttctgacggc acactccaag 2016721 gcattcccgc cagacgggca gcttgacggg aaggtatctg ccctgagccg gcctggacaa 2016781 ccatgcccat gacgtttcct tctacatcat ctccagagac tccagcctgt tgcagcgcct 2016841 ccttcatcac aatgccccca agctcagcag ctttcacctc tttcaaaact ccgccgaatt 2016901 tgccaaatgg agttcttgca gcacttacaa tgactgtttt cctcatggtt tcacctcatt 2016961 cagaagatag acagcgctta caatttctag ttgtcttcta tgaatgtatg ctttgaaacg 2017021 ggcatgaatg aatgaaaaaa gaaggctgcg tcaaacagcc tccttctaac aactattcat 2017081 ttttcagcaa tgccgaagcc ttttctggaa agtcggtaaa catgccgtct gctcccgctt 2017141 caatgagacg cttcatatct tccggacgat tgactgtata cggccttacc ttaatcaaac 2017201 cgttcctcat tttcttcagt acttcatctg tgacccctgg gctgtttatc ttcgggtgat 2017261 agccggaagc cggaatagac gcgatatatc gatctgcctg ataaagcaca tctgaagtta 2017321 atactgcccg ttcgatatgc ggtgcaagcc gggcgcacag cgccaagctg tcatgattaa 2017381 acgtggatag gatgactctg tcctctacat taaatcgctt cactgcctcc agcacttttt 2017441 cttccattcc ctcatagcgg atcacgctgt tttttaattc aatgttgatg agaaaatcct 2017501 tttttaccgc ccacgagagc acatcttcta gcagcggcac ttttatatcg ctgtacgctt 2017561 gatcgtgacc agcggccgca ttcgcagtct ttacctcatc ataggctgta tccttcacga 2017621 atcctttaag tgatgtcgtg cgattaagtc tttcatcatg aattacaaca atgcgtccgt 2017681 ctttcgtcag ctgtacatca agctctatcc catccgctcc ggcttcaatt cctttttcaa 2017741 atgcaagcat tgtattttcg ggaaattgac ctgatgcccc ccggtgggca aaaatctttg 2017801 tcatcgtttc acctcaaacc ctaaagtttt ctccattata cttattttgt cggctccact 2017861 ctaggattaa ggctgtatca atctactgat cataataaga atcaatgcca ttgacaatcg 2017921 catctgcggc cttttgctgg tattcttcac ttcccagctt gtccgcgtca gagctgttcg 2017981 tgataaaccc aagctccgcc aacacacttg gcatttgtga atatgtaatg acgtaaaagt 2018041 ctgattcttt cacgcccctg tctctcgttt gtaaggaaga aacgagctgt gactgaatat 2018101 cggatgccag acgccggctg ttctcccctt cataatcaga ttgaaaatac gtttctgttc 2018161 ctgaagctga agcaacccct gaattcacat gaatgctgac aaaaaggtca gcctgattgg 2018221 cacttgcctt agccactctt tcctccaagg tcagaaaatg atcgtcagac cgggatgcaa 2018281 caggattggc tccctcctct tttagtttgt ctgtcacatg ctctgagaca gccaaattaa 2018341 tatccttttc aaagagcccg tttccgaccg ctccactgtc ttcaccgccg tgtccggcat 2018401 caatatacac tgttttccct tctatcggct ctgctgcctg tgcacaaggc gcgagcgtca 2018461 aagccaatcc gcacagcgcc aagctcctcc ataacattct caacttactc cctccggtca 2018521 cgagttcttt cgcagctgaa tatcttccag ctgtaaagtt ccattatcct tctttgtata 2018581 tttcaccagg acatgtgtct gatctggcag tgattcacat tcatcacgtt tatccttcgg 2018641 aacttgtatc atggtttctt ctccattaag agaaaccgca atcgtatgag gatcagccga 2018701 gccaatgtat tttccctctt cggtaaacct cggcactgag tcatccgcac ttgcaacact 2018761 gcaccccgaa agaaagagcg cagtaaacag caaaagaacc gtttgtttca catgaccacc 2018821 tcttcctgat gtttggcttt tatctttgac cagaatggag aatttgtaaa gacaacgcga 2018881 atgcaggcga gcaagttcca tgattttcaa aagggctata cgacccgatc atttcctgtt 2018941 gttagaaaga taacgagcag atttgtctat gaggatggct ctaattgagg cgccaattag 2019001 aaaaaattag cggaaagaag caacttttta ttcattttaa aaaatttgag aatagggtga 2019061 gcaaatcgtt tgacgggtgg gtcagccaag cgtaaccttt taaaggatat ttactttatt 2019121 gaaagaagtt aaagccatga aaaaattcgt tctgctgctg gcggcagctg tcatcacatg 2019181 ctccatcggc caccaaatca gtggcggcta caaaggcccc gaaaaagagc ggccaaaaca 2019241 tcactctgca ctcaagatat tcagtcggta aagcagatca attgcattaa tttttacata 2019301 taggctagaa tatgtgcgaa tccaaacgaa agaagatgat caaatgaatc ctaagtataa 2019361 gccacttttt gaaccattta cgtttaaaag cggcgttaca atcaacaacc ggatcgcagt 2019421 agcaccgatg actcattacg cttctaatga agacggtaca atatctgaag cggagctcga 2019481 ctacatcatc ccccgttcaa aagagatggg aatggtgatt acagcctgcg caaatgttac 2019541 accggacgga aaagcattcc ccgggcagcc ggccatccat gacgattcca acattccagg 2019601 tttaaaaaag ttagcacaag ccattcaggc acaaggcgct aaagctgttg tacaaattca 2019661 tcacggcggt attgagtgcc cgtctgagct cgttcctcaa caggatgttg tggggccaag 2019721 tgacgtgttt gataacggca aacaaattgc tcgcgcatta acagaagaag aagtggaaaa 2019781 cattgtgaag gcgtttggag aagcgacaag acgcgccatt gaagccggct ttgacggtgt 2019841 cgaaattcac ggtgcaaacg gctacttaat tcagcagttt tattctccga aaaccaacca 2019901 gcgcacggat cgctggggag gaagcgatga aaaacgatta gccttcccgc tcgctattgt 2019961 cgatgaagtg aaaaaagccg cttcagaaca tgcgaagggt gcattcttag tcggctaccg 2020021 cctgtctccg gaagaacctg agacaccggg attgacaatg actgaaactt atacgcttgt 2020081 tgatgcttta ggggataaag aattggatta tcttcatatc tcactgatgg acgtgaactc 2020141 aaaagcgcgc cgcggtgcag atccgactcg cacacgcatg gacttattga atgaacgtgt 2020201 cggaaacaaa gtgccgctga tcgccgtcgg ttccatccat tccgctgatg acgcgcttgc 2020261 cgtcatcgaa aacggtattc cactggtcgc tatgggacgc gaaattctag ttgaccctaa 2020321 ctggacggta aaagtaaaag aaggccgtga aaagcaaatc gaaacagtga tcaaaggcac 2020381 agataaagaa aaatatcatt tgcctgaacc gctatggcaa gcaattgtga acacacaagg 2020441 ctgggtgcct tataaagatt aatgtgcaaa gactgccgaa acgattcggc agtctttttt 2020501 ccctttatat aaatagtttg tgtacacatc taaacagcaa aagaaagagc tccccaccaa 2020561 cttcgaaaag aaaatccagg aaaaacccct cacgctttct tgcttttttc tttttcattc 2020621 gtacgtctcc tttttacatg aatacgcctt acttacgatt ttgcaggaga aaggtttcat 2020681 tttataacgg acacatctag ggtcgatcat gcttcgtgat cctataagat gtatgaatgg 2020741 accaagagtg caggtaatac cgccatttgc tttccttact tttcaaacct atcctttact 2020801 atatgcggat acttaatatt cttctcccat actacaaatg tccccaaaac aaaacgcctc 2020861 ctatttatca gcgcaaacta ataaataaaa gacgtttgat ttaatgacca cttaataagc 2020921 tcatgtttaa gaagccttat gctctaacct cagcttatcc gcaaccattg caatgaattc 2020981 actgttggta ggtttagctt ttgtcatgct gacagtataa ccaaacaacg aggaaatgga 2021041 atcaatgttt cctctgctcc atgccacttc aattgcatgg cggatcgctc tttctacacg 2021101 gcttgcggtt gtgttaaatt ttttggcgat gtccggatag aggacttttg taatgctgcc 2021161 gagcaattcg atgtcattgt ataccattga gattgcttcg cgcagataga gatagccttt 2021221 aatatgggct gggacgccga tttcatggat aatgcttgtg atgctcgcgt cgagattttt 2021281 cttctttggt tcaggctggc tgctgcgtat aatactgctt tgcgatgatg gcgcacgatg 2021341 cgtcacactg ctggcatttc cgctgacctg gcggatatgg ccgacaaggt tttccatatc 2021401 aaacggtttg agaataaagt aggacgcgcc taaatcgacg gcctttttcg tgacatcttc 2021461 ctgcccaaag gctgtcagca taatgacatt cggctgtttt ttcagatctg attccctcag 2021521 cctctctaaa accgcaagtc cgtctagatg cggcataata atatctaata cgagcacatc 2021581 gggatctttt tctttaaaca gcgacaggca ttcctgtccg ttataagcaa cgccgatcac 2021641 ttccatgtct tcctgtcctt ctatatattc acttaacagg cttaccagct ctcgattatc 2021701 atcagcaaca caaactttaa ttttctccac gtttcttcct ccccaaatgt agttaacagg 2021761 attcaccctt gctacatgtt tacattcgac aaaaccgcta tataccctct aaaaaaatca 2021821 taatcaccaa tattagtggc atatctttgt tattctatgt ttttctctgt ttttcgacta 2021881 aaaatgaaat ttgacaaaca aggaaacgtg aatttgtcga aaaatcttct tttgtatatt 2021941 ttaccgtatg tattctgaga agtgaagagg gatcaggata tactgatgaa cgaatggatg 2022001 tgcacgaaaa aaataagctg cgcttctcgc gcagcttacc cagttgtttt gacttgatcc 2022061 gcttgtttta aaagttcttt cgcatggcgt ttcgttaagt cggttacttc gacacctgca 2022121 atcatgcgcc cgatttccgc taccttttcc tgcttagaga gcggcttgac acgtgtcgtc 2022181 gttctgccgt cttttaactc cttcgcaata taaagatgcg tatcggccat ggcagccacc 2022241 tgaggcaggt gtgtaatgca cagcacttgt gatcctattg acaccttatg gatcttctca 2022301 gcaattgcct gtgcgaccct gccgcttaca ccggtatcaa cctcgtcaaa aatgatcgat 2022361 gtcacatcct gttgtgagga aaaaatgctt tttatggcaa gcatcacccg tgacagctct 2022421 ccacctgaag cgactttcga aagggatttc agcggctcgc ctgtattggt tgaaattaaa 2022481 aacttcacca ggtcaatccc ttgttcagtc agctgaacgg gctggccgtt tacaagcggc 2022541 gcctcttcat tgcgtgacgc tgttctgacc ttaaattccg tatcaaaagt tgatttttcc 2022601 atgtacaggc tttttaattc ccgatgaatc tcatcagcca gctttttcgc ccatgttttt 2022661 cggatttgtg acacatttgc cgcttccact gcgacatctt tgccgacgga gtcaagctcc 2022721 tttttcaagc tttgaaggtg gctgtccctg ttttcaattt ggtcaatctc ttcttcaatt 2022781 ttagaagcat attccaaaat gtcttcaaca gtggcaccgt attttcgttt cagctgtttg 2022841 atttcattaa gtcgcgtctc aatatagttc aggcgttccg gatcaaattc aagctcatcc 2022901 agcatatttc tcatctgaaa tgtggcatcc tcaagcaaat agtaggagtt cgaaacactt 2022961 tcagacattt ttttcagcgg ttcgtttata tcagatatat cttcaagctg cgctgatgcc 2023021 attccaaccc agtccaatcc gccctgctca ctgcgaagcg cgttatatgc attttgcagc 2023081 gactcatata tcttctcaaa gtttgaaatt tgctggcgct cttcttggag ctgttcatct 2023141 tcgttaagct caagctttgc cgattcgatt tcttcgagct gaaattgaat aagatcaaga 2023201 cgatgggcca tttcctgttc gctttcagaa agctgcttaa gctttttgag cagcttcaca 2023261 taccgctggt acccttcctg atacgttttg agcgcgcttt ccacttcggc cccggcaaac 2023321 ttgtccaaaa gctggagatg attttcgtct tccattaaca gctggttatc gtgctgcccg 2023381 tgaatatcta ataaaagcct gccgatctct cttagtgaag caatcgtgac aagcttgcca 2023441 ttgacacggc aaacgctttt cccgctcgtg ctgatatccc ttctcatgac gatcatttcg 2023501 tctgaaacgt cgattccctg ctcagcgcat acgcctaaaa caggatggcc gctctccaac 2023561 agaaacagcc cttcaagttc ggcttttgct tccccatatc taacaaattc agatgatccg 2023621 cggcctccga ctaaaagaga aatggcatct atgatgatgg atttgccggc tccggtttct 2023681 cctgttaaaa ccgtaagccc gcgttcaaaa gaaaccgtca gttcctcaat aatggcaaag 2023741 tttttaatcg atagttcagc taacaaacag cattacacct cttatctttg ttagattttc 2023801 tgttacagca gttcaaggag cctgtttttt acgccttctg tatcttcagg agtccggcaa 2023861 ataattaaaa tcgtatcatc tccgcaaatg gtccccatca tttcatccca gtccaaattg 2023921 tccatcagcg ccccgattgc ctgggcattg cccggcatcg ttttcagcac aatcatatgg 2023981 cttgctgagt ctattttcac aaatgcgtcc atcaatgccc gctttagctt tgacagcgga 2024041 ttgaaacgct ggtccgccgg aagactgtat ttgtaagaac cattatttgt aggcactttt 2024101 acaaggtgaa gttctttaat atcccgtgat accgtggcct gcgttacttt gtatccatcc 2024161 tgctttagca tgtcgaccaa ttcatcctgc gtttcgattt cattgcttgt aatgatctct 2024221 ctgattttaa tatgcctctg gcctttgttc atgtaagcac ctctatttcc aagcttatct 2024281 gttcttttat gttatatgat tctctgcaca ttgtacatga atgcagaaaa aaggaataat 2024341 agcgccctat tattccggta catctgcttt tttttctttt aacgtcttat gtgcttcttc 2024401 tacaacgcgc atgatctctt cttccggcag ttcctggcct tcctgtccct ctcccggcca 2024461 atgcaaatga aggagaaact caatatttcc gtctcctccc gtgattggag aaaatgacaa 2024521 gcctttacag atatagcctt cagcggcaga aaaactgatc attcgcttga gcacatcagc 2024581 atgcacttta ggatctctaa caatcccttt tttgccgacg gattcccgtc ccgcttcaaa 2024641 ctgaggctta actaaagcca tgcagtcgct gcccggtacg agcaaagtcc ttaggacagg 2024701 caggatgagc cgcagtgaaa taaaggacac atcaattgtg gcaaactccg gcatgccctt 2024761 tgtaaagtct gccggtgttg cataacgaaa gttcgtccgt tccatcacga cgacccgttc 2024821 atcctgtcta agcttccatg caagctgatt atagcctaca tccacagcgt atgactgttt 2024881 agctccattt tgcaaagcgc agtccgtaaa accgccggtg gaggagccaa tatcaatcat 2024941 aattttatct ttgacagaga cgggaaattc cttcaacgct ttttcgagct ttaagccgcc 2025001 cctgctcaca tacctcagcg ggtttccttt gacagttaac ggaaggtcgc ggtcaatttt 2025061 ttctccaggc ttgtccaagc ggttttcgtt tgaatagacg atccccgcca taatggctct 2025121 tttggctttt tcacgcgttt ccgccagccc tctttccact aataatacat ctaatcgttc 2025181 tttctttgac gtcatgatcc aattcctttg tgtgtctttg gtggcatcag taatctaata 2025241 cgatttgcca cctgctgttt tgtcagtcca atttcctcaa gaagcgctgt tacacttccg 2025301 tgttcaataa accgatcagg tatacccatt ctgtcaatcg gagtatgata ttcaccttga 2025361 tcatgagcga attctaaaat cgagcttccg aaaccgcctt ctaagaccgc ttcttcaatt 2025421 gttaaaattg gcaagccttc ttttaggata ctcttcatca tcttttcatc aatcggctta 2025481 ataaaacgcg cattcacaac gcgcacggaa aggccttctt tctgcagctc ttcggctgct 2025541 tcaatcgcca tttcgattgt tgtgccgaat gttaagatga cagcatcgtt ccctggacgc 2025601 agcacctccc acgtaccgat cggaatcgtt ttcaactgtt catccatttt tacgccgagt 2025661 ccgtttccgc gcggaaaacg cattgctatc gggccttcgt catagctaag tgctgtatga 2025721 accatgtgct ggccttcatt ttcgtctttc ggcatcatta agaccatgtt tggaatgtgg 2025781 cgcataaacg caatatcaaa cacgccttga tgtgtctctc catcagcgcc aacgagtcca 2025841 gcacggtcaa ttccaataaa cacattagcg ttttggcggc agatgtcatg aacaacttgg 2025901 tcatatgccc tttgcaggaa ggttgagtaa atcgccaaaa acggcttcat accctgcatt 2025961 gccatagctg cagccattgt tgcggcatgc tgttctgcga ttcctacgtc gaacatccgg 2026021 tcagggaatt cctttgcgaa gccttcaagc tttgaaccga caggcatagc cggcgtaatg 2026081 gctacaatgc gtccgtcctc gcgcgccatt cgctgcacag ttccgctgac aagaccgctc 2026141 cacgaaggag ctgcggcttt cggctttaca aagtcaccgg tattaatttt atatggtccg 2026201 gtaccatgcc atgtcccaat cgtatcggtc tcagccggtt tgtacccctt cccttttttc 2026261 gtaatgacgt gcagaagaac agggcctttc gtttttttgg cgtattgaag attctcaatc 2026321 agctcatgat aagaatgtcc gtccactggg cccaaatacg taaaaccgag ctcctcgaaa 2026381 aacattccgg agacgagcat gtatttcagg ctgtctttga cccgttccgc cgtggcggca 2026441 agcttgcccc caactgccgg aatcttttta aataagtatt caagctcatc tttgacccac 2026501 tggtatttcc ccgcagtgcg gagccgtccg agcatagagt gaatggcacc gacgtttggc 2026561 gcaatactca tttcattatc attaaggatg acaatcatgt cttttttctc gtcgccgatg 2026621 tggttaaggg cttcgagcgc cataccgccg gtcagcgcgc cgtcaccaat gatcggaata 2026681 atatattcat ccgttccttt aatatcacgg gcagctgcca ttcccatcgc gcctgacaga 2026741 gaagtcgagc tgtgcccggt ttcccaaaca tcgtgctcgc tttcactccg ctttggaaat 2026801 ccgcaaagcc ctttgtactg gcgaagcgtc gcaaattctt ttccgcgtcc tgtcagcagc 2026861 ttatggacat acgactgatg gcctacatcc cataaaaatt tgtctttcgg gctgttaaat 2026921 tccttatgca gggcaacagt aagctctacg acacctaagt ttgggccgat gtggccgccg 2026981 gaagcggata aacttgtaat taaaaactga cggatttcat cacttaattt ctctaattca 2027041 tcaatggaca tgttttttaa aaacgacggg tcctgtattg ataaaagatc caaagcggat 2027101 caactcactt tcagcatgaa tttctgcaat gatacatgtc ttttgcatgc cgagctgaca 2027161 ataatctcag acataaaaaa agacaaacgc gcttttcctt ttcatttttc atataaactg 2027221 cttacatttt accatacctc gtgcagccgc ttcaaattag gatcgtttta gtgatctctt 2027281 gccgcaatta aatcacaaag ctcatataaa aggtcttttt gaagagagag tccgccgatc 2027341 aatcgcttcg cctcttttat atgaacatcc aatttatgtt tggccccttc caatgaaaga 2027401 agcgacgggt atgtcgattt gtcatttgtg gtatccgagc cgacacgttt gccgattttc 2027461 tcttcactgc cttctaaatc taaaatatcg tctctgattt gaaatccgat tccaatgtgg 2027521 ctgctgaagg tacgcagtgt ttcaatgtct tcctcaggcg catcagccaa aatagcaccg 2027581 gcgattacac aaaagccaag gagcttggca gttttccgtt catgaatgga ttcgagctct 2027641 tcaagcgtga cttgtcggtt ttccgcttcc atatcagcta cttgcccacc gaccatgcct 2027701 tcggtgcctg ccgctgaaat cagttcattc acaagccgca ggcgcttttc tgctgacacc 2027761 tcgtctgaca cgtgggaggt aatcagctta aagctttctg tgagcagccc gtcacccgct 2027821 aatactgccg tcgcttcacc aaacacttta tggtttgtcg gcttcccgcg gcgcaaatcg 2027881 tcatcatcca tgcatggaag atcatcatga attaacgaat acgtgtgaat catttcgaca 2027941 gcacagccca ccggaatgcc gtctttttcg ctttttccat atgcatttaa aacagccagt 2028001 acaatcagag gccgcaaccg ctttccgccg gcctgtagag aatatagcat agatttcttt 2028061 aatgagtccg gcatatcaag cttttctgta tagacagaaa gctgattttc aattgttttt 2028121 ttccggtccg ccagaaagct cgttaattta tttgtcacct tcgtcttcct cctgaacact 2028181 gaaaggtgcc agttcgccgt cttcttttaa aatgaagtcc atttgctttt cgactttttg 2028241 cagcttttca tggcacattt ttgacagagc catgccttct tggaaatagt taatggcttg 2028301 ctctagaggc acatctccct cttcaagctt tgatacaatg ctctcaagcc ctttcatcgc 2028361 ttcttcaaat gtcatgtttt catttttttt cacgtctgtc atttttcttc ccctctcttt 2028421 tctaatactt cacaggtcag cacgccatcc ttcagcttga tttcaagccg gtcctgctct 2028481 tctatttgac tgacactttt aatgagttta tcttctttat aagccaagct gtatcctctt 2028541 tccatcactt gaagaggact tagtgcattc agcttgccaa gaacggtttg aaattgggaa 2028601 tgcagctgct tcatttggat attcatattt tttctcagct gatttgtttg ttcctggtat 2028661 cgtgttctcg cttgtttcag ctgttcatga ggatgcaatg cctctaatct gtacgtttca 2028721 cgctccagct gtctgctttt ccgatctaaa agagcggtca gctgtgcttg aaactgctgg 2028781 tacgcgaggt caaactgctg ctctttttgc gcatacaaac gctttggaaa acgaaaggca 2028841 taggacgatt gcagcgtttg tatccgttct tttttctggc cgagatgctg ctgcattgct 2028901 cttgtcattc tgacttccgc tgtttttgtc cgttcgatta aatcagtggt atgaggcaca 2028961 gcaatctcag ctgctcctgt cggcgtcgca gctctgatat cggcgacaaa atcactaatc 2029021 gtaaaatccg tctcatgtcc gactgccgat ataatcggaa tattggaagc aaagatggcg 2029081 cgtgctacaa tttcttcatt gaatgcccac agttcttcta tcgaaccgcc gcctctcccg 2029141 acaattaata cgtcgcaaat ctctttttca tttgcctctt caatgcgcgt aacgatggat 2029201 ctgctcgcat tttcaccttg tacgagcgct ggaagaacaa tgacttttac aaggggatat 2029261 cttcttttta gagttgtaat aacgtctctg acagcggcac ccgttggaga tgtcacaacc 2029321 ccgattgtgg ctggaaatgc ggggatttgt tttttgtagc ggtcgtcaaa taaaccttct 2029381 ccggcaagct tcttttttaa ttcttcgtac gctaaataaa gcgctccaac cccgtcaggc 2029441 tgcatttctt tggcatataa ttgatagttt ccgctcggtt catatacgga aattccgcct 2029501 ctgaccagca ctttcattcc gttttcaggt ttaaaaggca gacgctcgct ttgtctcgcg 2029561 aacatcaccg actgcattct tgcgttttcg tcttttaaag tgaaataaat atgccctcgt 2029621 gtgtgtatct ttacattcga caattcgcct ttaatccaaa tattttcaag gtgaggatct 2029681 acatcgaatt ttcgttttat atactttgtc agcgctgaga cggtcacata cgctgcttca 2029741 cccatgtcta aaaactcctc tcctaagcat tcctgcacca taactaaaga aaacccgccc 2029801 tggctttagg agcctgaaga agcgggtatc gtgctcatat tcaaggcggg taaacatttc 2029861 gcctgtgaat atctccaatt atctatgata acgtacgttt cgcagattta acagtattat 2029921 gcgcaagcat cgtgatggtc atcggaccta ctccgcccgg aaccggcgtt atgaaggacg 2029981 ctttttcctt tgccccttca aattcaacgt ctccgcaaag ctttccgttt tccagacggt 2030041 taacgccgac gtcaatgaca acagcgccct ctttgatctg gtctgcactg atgaagttgg 2030101 ctctgccgac tgccaccacc aggatgtccg cttttttcgt atgttcagta atattttctg 2030161 ttcttgaatg acagtaagta accgtcgcgt tttcatttaa taaaagctgg ccgacaggtt 2030221 tgccgacaat gttgcttcgg ccgactacaa caacctcttt accggaaagg tcaatattgg 2030281 ttttcttcaa aagctcaaca attccatgag gcgtgcaagg aagaaacgta tcttcgccaa 2030341 gcagcatttt ccctacgttt aacggatgaa aaccgtctac atctttatca ggggagatac 2030401 gttcgatcac cgctttttca gaaatatggt ctgggagcgg aagctgaacg agaatgccat 2030461 gaaactcagg gtcttggtta tattgatcaa taatggaaag cagttcagct tctgtgaggc 2030521 tgctgtcaaa ttgatcgagc ttgaaattca ttcccattgt ttctgccgct tttttctttc 2030581 ctcgcacgta agagtgagaa gcaggatcat ctccaatcaa aataaccgcc agtccgggag 2030641 tgacgccttg ctttttaagc tcttctacct cttttgccaa ttgttcgcgt ttttctctag 2030701 ccgtttcttt tccgtcgatg attgttgcag tcattttctt tcctcctatg attgttcaat 2030761 atcagattta atgttagaaa gaaccccgtt tacaaacttt gtcgctttgt catcaccaaa 2030821 ccgttttgcc agctcaatcg cttcgttcat ggagacattc accggaatgt cttcggcata 2030881 tgccatttca tatgctgcca ggcgcaaaat cgcacggtca acattggcaa tccgatcgag 2030941 cttccaattc accagatgct tggagatcat ttcatccagc tggtcttggt gttccaatac 2031001 cccgtgtaca agctgttcaa agaaaggatc tgttttttct tcatccagtg cgtgttctat 2031061 ggcttcattc actgcaatat cgctgacatc aatttgaaat agtgcctgca aagctttttc 2031121 tcttgctgtt cttcttttca ttttctttct cctttgatcc tctttatccg cttgtcgtta 2031181 agccacaaag agatcataac atattttttt cgtatccgca tattgaaatc aaggtttttt 2031241 taccctatta ccgaatattt tcacacacct taatatgatt attcggattt cacgttcatg 2031301 aagaaactcg gctatgtaag ccggctttct tcatgctttg aaataaaggg taacgtgtaa 2031361 aaaaaccaaa gggccgccct ccccttggtt tcgtgttaag ccatttacat ttcttcgtcg 2031421 atttggactt cttgggcttt tgtgtcaaat tgaatgccga cgatgtgaat attgatctcg 2031481 ttaatcgaaa gagacgtcat atttaataag gtttgacgaa tgttttcctg aacggatgct 2031541 gcaactttcg gaatcgaaac gccaaatgta acgacacagt atacatcgat cgtaattccg 2031601 tcatccgcca ggtcgacttt gacacctttg ccatgattca ctttgccaaa gcgctcaacg 2031661 acgcctgtcg caaagtttcc gcgcatttcg gcaactccat caacttctga tgctgcaatg 2031721 ccggcaatga cctcaatgac ctccggtgca atctcaacct tacccaaatg cgtatcttcg 2031781 tgatccattt taagcaagct gttgtctttc attcaattca cctccgtaaa aattatgagc 2031841 ccattacatc atatgtttct aaaaatttcg tattaaactc tccgctcaca aatgtttcgt 2031901 gttcaagcag ttttaaatgg aaagggattg ttgtctcaat gccttcgatg acgaattcgc 2031961 tcaatgcgcg cttcatgcgg gcaatcgctt catctctcgt ttttccgtat gtgattacct 2032021 ttgcaatcat gctgtcatag tacggtggga tggaatagcc agggtacgca gctgaatcga 2032081 cacggacacc aagaccgcca ggaggcaggt acattttaat ttcaccaggt gacggcatga 2032141 aatttttgct tgggttttct gcgttgattc ggcattcgat ggcccagcct tcaaattcaa 2032201 catcttcttg cttgaggctc agttccattc ctgaagccac tttgatttgt tccttgatca 2032261 ggtcagttcc cgtcaccatt tctgtgactg ggtgctccac ctggattctc gtgttcattt 2032321 ccatgaagta atagcgctgt tcattgtagt catagataaa ttcaactgtt ccagcacctg 2032381 tatagccaac cgctttggca gcctttaccg ctgcatctcc catttgctcc ctgatttctg 2032441 aatcaagggc aggagatggt gattcttcca aaagcttttg caggcgtctt tggatcgagc 2032501 agtcgcgttc gcccaaatgg atcgtatttc cgtagttatc agcaagcact tggatctcaa 2032561 cgtggcgaaa atcttctatg tatttttcga tgtatacacc tggattccca aatgcagttg 2032621 ccgcttcctg ctgtgtaatc ttaatgccat taatcagttc ctcttcagtg cgggcaaccc 2032681 taattccttt tccgcctccg cctgcggtgg cttttataat tacaggatac ccaatttcat 2032741 tagcaagcga aaccgcttct tccacatttt ctataattcc ctgtgaaccc ggtacgattg 2032801 gcacgccggc ctgtttcatc gtttcccgcg caacgtcttt tgttcccatt tttgaaatgg 2032861 cgtcagcgct cgggccgaca aacgtgacat tcacttcttc acataattca gcgaaatcag 2032921 cattttcagc taaaaatccg tatcccggat gaatggcgtc cgtgccagtc agctttgcaa 2032981 cactcacaat atttgtaacg tttaaatagc tgtcttttga tgctttcggt ccgatacaaa 2033041 aagcttcatc ggccatttga acatgaaggg catctttatc agcttctgaa taaacagcga 2033101 cagtctcaat tccgagctct ctgcaggctc tgatgattct gacagcaatt tctcctctgt 2033161 tggcgatcaa tagcttttta atcatgttca gtctccttac tccgctttta caagaaatag 2033221 aggttgtccg tattcgacca gctggccgtt ttctactaat acttcaacga tttcgccttt 2033281 cacttctgct tcgatttcgt tgaaaagctt catcgcttct acaatgcaga caactgtgtt 2033341 ttcatttact tttgaaccgg ctgttacata cgggccagct tccggtgatg aagaagcata 2033401 aaatgttcct accattggtg aagtgatttt atgcagattc tcatcttgct ttggtgcttc 2033461 ttgggcaggt gccgctgctt gctgcgcttg cggctgaact gcctgcggag cctgtgcttg 2033521 tacaggtgct gccggtgcct gctgcatgac ttgaaccgtg cctgcttcgt gttttttcag 2033581 ttttaaggat acaccttcat tttcatatac gaattcgtca attgtagact cgtcaattgc 2033641 tttaatcagc tcgtggattt ctttgatatt taacattcaa tcgcactcct atgtatgaaa 2033701 tttctttttt tataggttac tactaaaagt acatactatg ttcatcttac aggagcggac 2033761 ttttgaattc aactctaata tgacagcaac gcaaaaagcc cgcttgttta gcgggctttt 2033821 ttccctcatt cttatttaga gggttcaaat gtgacagcga catctttcat tgttttgatt 2033881 tcttttgcca caaggtctat aatggctgtc gccttcgatt tagagtgttt gtctgatttg 2033941 actgtaatat tgattttatc tccttcagca ttaacaagcg catcctcgta accttgtgtt 2034001 ttaatcagcg tttccagctg tttttctgtt ccttccactt cactgagagc cgtcatttta 2034061 tcgtatgctt cgcttttctc cttggctgtt gcatcatcgc ttgacacaat ggcattcagc 2034121 tcttctcttt ctttgcttct ggcatcttct aaatcaagac ggtacgttgt aaacaaatca 2034181 tcatcggctg tttccgtaac aacagttcct ttttcactgg cttcagcgga tgtttccttg 2034241 tctgctgatg aatctttcgt tccctttgtt ccatcttctt ttcctttttc agtttctgta 2034301 ccgctttttt ccttcgtgtc ttgcttggca ggcgcttttt cagttgcgac ctctccgctg 2034361 tcagacgcgc ttttttcact ttgcatctgc acggcgtttt tgctttccgg cgacatgata 2034421 tagtagacgc ttaacaccac gacaagactg agcattgtta atagccaaac ggtttgtttt 2034481 ttaagcattt atgaatcctc ctttattttt ttaggggcaa ccgcaacccg gtggcttgga 2034541 acatccagga cccgtgtcac cgcttcgata atggtttgtt ttatttgaac gttgtccact 2034601 ccttgagcaa caacgagtac accgcgtata tcaggttttt tcgtttggac gacgacaggt 2034661 gtttctttat cgccgttttt gatcatgacg atttcttcct ccgatgattg gtctgtaacg 2034721 cttctttttc cgccttcttt gtcagtttct tcagtggttg tatttttgtt tgatttgttt 2034781 ttttcgtata ctttcagcga cgttgcatct acattcacga caaccgagac atcgtccaca 2034841 ccaatgattg tttcaagaat ttctttcagt tgattttcgt attctttttc atagtcatcg 2034901 atcgagtctt taggtttatc agattttgag gctttaaaca cttcggctgt tttctctttg 2034961 ctgtctgcgg aatgttgtga tgatacggcc gttatcgttt tggcgttttc agttttctca 2035021 ggtgaagaaa acagctggct gacaagcata aaggaaactc cgagaacaaa aacgaataga 2035081 aagtaatgat atttggtcag cttcggcttt tcgccgtcct tcgtttgtcc cggaagaaac 2035141 tgctttttca atacattcca taatccgttt ttattcattg ccgacactct ccccgccttc 2035201 catatgaacc gtaattttct cacttccgat ttcccaaatg tccgcgagct gcgtttgtat 2035261 ctgtttggct tctttttgtt cggctgcttc ttttgttacg tatgcatgat ctgtatcaat 2035321 gtggaccggc gcgaccgttt ggaccgtttt ttcagaagac ggggccatat acacgctgat 2035381 tgttttaata tcctcttctg aatctacctt ttctcctgcc gtgagtttga tgcggcctac 2035441 tttatattca tcatgactga atctctcctc cgctttcttt tttagttgga cagccatttc 2035501 ttctagaata tatgcgcgct gggaagcttg tatttctatt ttttttgaat tgatttgatt 2035561 ttttatgtcg gcagactctg actgcccgtt ttttgtgagg tattcaaaga tgacttcggg 2035621 gtctgtcttg aaaagtttaa aaatcggcgt aagcatgacg acaatcaaga gcaggctgac 2035681 taccattttt gcgtactttt gcatgctgga gctcggcagc agcatatcaa tcacaattgc 2035741 aaataggata aacaacacga tggtggtaag ccattccgtt aaaaaactca tttgcctgcc 2035801 tccttcattt catcatcatc gtgaggtttc cggctgtgat tatgacagta aggcttaaaa 2035861 aaaacatgag agacacaatg gcgagagctg caaaaatata aatgacgctt ttgctgatga 2035921 cgtcgaggca ggtgatgacg ggcccgcctc ctagcggctg aagaatcgcg gctgccagct 2035981 tataaataaa agcgagggaa agcactttga ttgccggaaa tgccgcaata cagatcaaaa 2036041 tagcgacacc gagaatccct accgtatttt tcagcagtaa agaggcgctg attactgtat 2036101 ctgttgcgtc tgtaaacatt cggccaagca caggaataaa atttccggtt ataaatttag 2036161 ccgtcctgag cgtaatgccg tctgtcactg cagctgacgc tccctgaaca gagatgacgc 2036221 cgagaaagat ggtaagaaaa acagccagtg ctccgatggc gatatttctg agcaggttag 2036281 ccagctgcgt tactttgtat tgttcagtca tcgtgctgac aatgctcaga atcgctgata 2036341 aaaaaatcag cggcatgacg atattctgaa tcaagagacc gctcgtgttc atcaggaaga 2036401 ggataacagg atgaaagaag gcagcagata cagctccgcc tgaggaagcc aaaagcgcca 2036461 agaggagcgg aatgagcgcc aggataaagc tggtcatcgt ctgaatcgcc tcagttgcat 2036521 agttaattgc cacatgaaag ctattaagcg caaggataat cagcaccatg tacacaattg 2036581 agtaagcgac cttactgacg gtgctttgct gaaaagcatt ttgcaaaagc tgcagaatga 2036641 cgcaaaaaat cgtgagcaaa atcaatgtgc ccagcagctt tccgttggca agcacttcat 2036701 gaaacaaata agaaaagaga gctttcagcc attcttgcgg tgagaatgat ttatcgccat 2036761 tgataaactc cattaagctg cctttttggc tttccggcag cagtccgccg tattctgtca 2036821 taatgtcatt ccaaaattcc ccgatcttat ctgtttcaag cgaggctgct gtcctttccg 2036881 ctaattgctc ggctgtttca gcatggtctt ccgtttgttc tgcattacca gctgcttgta 2036941 caatttctgc acggcctgct atgatcagca cggccaaaag caaaacccat tgaaagcgct 2037001 tcaatctacc gcctcctttc ggttatgaca tagaaggtat aagtccgaga atcgtttcga 2037061 taatgacggt taaaataggc acagccatta cgagtattaa aattttcccc gccaattcta 2037121 ttttcgaggc gatggctcct tgaccggcat cttttgtgag ctgtgccccg aattcagcaa 2037181 tataggcgat tccgataatc tttaaaatgg tttcaacata gaccatgttg acatttgcat 2037241 taatcgcaat tttttctatc attcgaataa tgtcgtagat ttggtctacc aaataaagaa 2037301 aaatggcaca tccggcaaaa acgacgatta aaaacgcaaa agtcggcttt tgttctttta 2037361 caattaaaga aaggaaggtg gcgatcagcc ctaaacctac aatttgaaca atgtcaatct 2037421 gcaagccccc ctatccttgg aataaaaaca cagcttttat ctttttaaat aggtcatcta 2037481 caatcgtggc gaccataaat aaaatataga taaaacctaa cagcgtcacc cactgagcat 2037541 attctttctt gcccatctga tccaatatcg tgtgtaaaaa agcgaccacg attcccactc 2037601 cggcgatttg aaatatgaca ttcacgtcta ctcccatttt atttttgctc ccctcacgtt 2037661 tacatcaata gaagaatgag taacaagccc gctaaaaagc ccaaactttt tatcatcttt 2037721 tcgtttttcg cttgcgcctg ctcagcatcc gcttctgagg cttccaaatg tgtcagcgcc 2037781 agcttgatgt gcttttgctg agagattcga tcatgaatcc caagcgtctc gccaaactgc 2037841 ttcagcactt cgtattcgct ttttttcaaa gacagggtgt cccatacctt ctttaagctt 2037901 tgctcccacg ccgttttcgc ggaatcactt cccttgtcca gctgatcact gaatgcggaa 2037961 aaaagagttg aaacaggctg tgcgagctgt ttggcaatct gctgtgaagc agtatgaagc 2038021 ggtgtatggc cgtacatgat ttcagcctcg agggattgaa gcgccgcacg cagctggcgg 2038081 atttgccgcg gccgttctgt ataaatcttc gccatctcaa aacctgtcca tgttgtcgct 2038141 accacaatga atacagcgcc cagcagcttc agcatgtttt cacgcccgtc gtcctagaca 2038201 gcacatttcc gtctttgtca taaatttggc tcactgtgcc cggccctttt gctcttgata 2038261 attccaaata gcggtcaaag gctctttctt cccacaaacg cttcaatgaa ggccgcttca 2038321 tcaggtcgga tatactccag ccatgcgccg atacgattac tgaaacaccg gcatgcagcg 2038381 cctccagaag tgcatctgta tcttccatac gcccgatttc atcgacaatc atcacctcag 2038441 ggctcatgga tcgaatcatc atcatcagcc cttcagcttt tggacaggcg tctaacacgt 2038501 caattctctg accaaattga tgctgcggaa taccgcgaag acatccggca atctctgacc 2038561 gttcatcgac gatccctgtc tttacgggca gcatgttttt tttgccggtg cttgagagcc 2038621 tcgcaaggtc ccggagaagt gttgttttgc cggtttgggg cggtccgata atcagcgtat 2038681 tcagccagct gttttgatat aagtatggaa gcagcggctc cgcaatcccc agcttttgcc 2038741 gggcaattcg tatattaaaa gatgcgatgt cacggaggcc tttcacacct ccgttttccg 2038801 taatgactct gcccgccagt ccgactctgt ggccgcctct gatcgtgaca taccctttct 2038861 tcagctcttc ttcaagtgta tacatactat agttgctgag ccggctcagg atcagatggg 2038921 catcctcggc cgtgcccgca taggacaaat aaacaggttg tcctcttcga atcaattcaa 2038981 cagggcggtt gatccgaatt ctgacttctt cgatttccag ccattgttgt tccggtattt 2039041 cagaaagggc gtttttcatg gattcaggga gaacctcagc gatttcattc aacagagcct 2039101 cctcctttct accgattggc ttctttaaaa tgtatgatgt gaggcagact ttatgacaag 2039161 cctctcttta tttatgaaca cccgccaaaa tcaagacaac acccgtaaaa atcagaatca 2039221 gctttgcata cgaaagctgc ccggcaattt ggtagattcc gacagtcatt gtaatgataa 2039281 aaatcaacgg accgacaata gcgagaatgc tgttaaccac aaccgccttc cggacatcgt 2039341 tggtcacaag catgacaatt gctgccgtca gctcaatcat agaggataaa actcgtaatc 2039401 ccgccattgt taaaacagta gaattgatat ttccaagtaa aaatttcata gcactctccc 2039461 aacctcccat ttttttatat gatatgctct agcttgctga agtagtcttg tcattttcgt 2039521 ataaaagaaa gattctgttt ttgggcacaa aaaaagcctg ctcccatttg ggaacagact 2039581 tctttttttc tttctatgct cttgaaacgt aagaaccgtc tgatgtattg acaacaagtg 2039641 tgtcgccttc attcacaaag aacggcacgt ttacaacaag cccggtttca gttttcgcag 2039701 gttttgtacc gcctgacgct gtatcacctt taataccagg ttcagtttca acaactttca 2039761 gctcaactgt gtttggaagt tcgataccaa gtgtttcatc ctggtacatc atgatatgca 2039821 cagacatgtt ttctagcagg tattttaatt cttcttcgat ttgagttgcg ctcagttcaa 2039881 gctgctcata agaagaagta tccataaata cgtgctgatc tccgtttgca tatagatatt 2039941 gcattgtttt ggtttcgatt tgcgctttcg ctactttttc accagcgcgg aatgtttttt 2040001 cctgaatcgc gccagtgcga aggttgcgga gtttagagcg gacaaatgcc gcaccttttc 2040061 caggttttac gtgctggaag tcaacgacgc gccaaatgcc gccatctact tcaattgtta 2040121 atcctgtacg gaaatcgtta actgaaatca tgtttaatgt cctcctatat tccaatcaca 2040181 aaataataag ttcttttggg gaatgggtga ttgtccggtt gccgttttct gtaatcacga 2040241 tgtcatcttc aatgcggaca ccgcctgttt ctggtatgta aatgcccggc tccactgtga 2040301 ccaccatacc cggttcaagg atagctgaag atctgacgga taatcccggc gattcatgaa 2040361 cttccatgcc gagcccgtgc ccggttgaat ggccgaaata gtcaccgtag ccttttgcag 2040421 caatatgatc ccttgtgagg gcgtcagcct cttttcctgt cattcccggc ttaatatgtg 2040481 cgacgccaag cgcctgagca tcaaatacaa cctgatagat ctccttcaat tgatcactgg 2040541 gctgacctac agcgaccgtc cgggtaatat cagaacaata tcctttataa taagcgccaa 2040601 aatcaagcgt aacaaggtct ccgctttcaa tcagtttgtc actggccaca ccgtgcggaa 2040661 ggcttgaacg aaggcctgag gcgacaatca tatcaaaaga agagctgtct gctccctggc 2040721 ttctcatata aaactccagc tcattggcaa cagcgatttc agaaatgccg ggtttcataa 2040781 acgtcaagat atgtctgaag gcatcatctg caatcttcgc agcttcctct aatatcttaa 2040841 tctcttcact agacttaatc aagcgcaact tttccacgga ttcagccaca ggcactaatt 2040901 cggcatcact gataacggcg ctgtatgaag cgtaagtgcc atatgtcatg ctgttctgtt 2040961 caaagccgag acgcttgatg ccaaacgatt caacagtgtc ggcagtggtc tgaatcaagc 2041021 tgccgccatg ttcaatgatc tcaaaaccct ttacctgaac cttcgcctgc tcagtataac 2041081 gaaaatccgt aataaacgct gctttgtcac ccgatataac agccaaaccc gccgaacctg 2041141 taaaccctgt catatagcgt acattagtgt tgcttgtaat cagcatgccg tcaattccca 2041201 gctgtccaaa caggtttctt aatttctcta gcttcatctt gattctcccc cttgctggct 2041261 taataagtag cgaacagcaa gcttgtagcc ttcagctcca agaccgacaa tctgcccttt 2041321 cgcaacagga gcgataaccg actgatgcct gaattcttcc ctggcgtata agtttgataa 2041381 atgcacctct accacaggaa gactgatgct tgaaacagca tccctgatcg catagctgta 2041441 atgactcagg gcgccggggt tcagaacaat cccgctgtat tgctcctcag cctcatgtat 2041501 cgcatctatc aaatcacctt cgtgattaga ctggaagaaa gtgagctgga tatgtaaggc 2041561 ttcagcaaac tgaaaaagat ctgtttcaat atcggtcagt gtctggcggc cgaatacttc 2041621 aggctcacga ctcccaagcc ggttaacatt cggtccgttc aaaatcaaaa aatgaggcac 2041681 acaatctctc cttttcgcga gggtttctca tgtaaaaaat gttcacttct cgtgaacatt 2041741 ttatcatact ggaaaaggat tatacactat tctctatgca ttcccagcgc acgtgcaagc 2041801 ttttccgaat tcagctcatt gtattcaaat gaaatagaat acccgacaaa cagcccgtaa 2041861 agcaaataaa tgcaaatggt cgtaataatt gtatctgatg tcagttcggt caccgtgcgc 2041921 acatctggaa aaatcggatt aaaaacaaaa aacacgagca gccaaagcac caagccgtat 2041981 aaaatacccg gccacattgt ttttaaacgt ttcaatagaa gaaaataaag aaatgctgcg 2042041 ccaattgaaa ttactccaat caaaatgatg ctgattaccg ttcccagccc atgttttttc 2042101 cactctccga gtacaaacgg ctgcaatatc atattcgggc tgatttcgga aaaatgaaac 2042161 aaatatgcga tataagcaac gaaactccaa agtacgcctc cgcaaaaacc tgttgccgcc 2042221 accctgccgg ccattgaaac aggcggcttt tgcttctcat tcaattcttc attttgttct 2042281 gtatcttttt cgcttgtcat catggcacct ccagttaaag tgtgcccaaa aaatgaaatg 2042341 tcaataaaaa agctcacact ttttggcagc tgcgagtaaa atttgaaaat aacgggtata 2042401 atgcatgtag aaaaagcaag gctatggcaa ttttttcagc ctgtcaatct agaggtttag 2042461 cgctgtttcc tgtacaatag agtgaaagga aatggttagc aatcctaaag aaataggcag 2042521 gttgataata tgtcaaaaca taaagttccg cccgcttacg gcgggcaggc tgttgtggaa 2042581 ggcgttatgt ttggcggaaa gcatcattac gttacagcca tcagaagaac ggatggaagc 2042641 attgactttt ttaagcttcc acgcaaacac aacccgaaac tgaacatcgt gaaaaagata 2042701 ccgtttttac gggggatcgc ggccattatc gaagcgagtg caaacggcac aaagcatttg 2042761 aatttttcaa gcgaacgtta cgggctcgat ccatctgaag acgagacact tgagcaggaa 2042821 gaaaaaaaat cctctgggct gtctatgtat ctcagcctcg cagttatagg cgtcctatca 2042881 tttttgttca gtaaattcgt atttacattg gttccagttt tcttagcgga actgacaagg 2042941 ccgatttttt ccttgaacac agcgcaaatc gcgattgaaa gcctgtttaa gttgattttg 2043001 ctgctcggtt acatctattt tttgtccatg acaccgctta ttaaaagagt gtttcaatat 2043061 catggagccg aacataaagt cataaactgt tatgaacaga atttgccaat tactgtggag 2043121 aatgtccaaa accaatctcg gcttcattac cgctgcggat caagctttat tttatttacg 2043181 attattgtcg gcatgtttgt ttatttactc gttccgacag atccgctttg gctgcgtgtt 2043241 atagatcgtg tcgcactgat accggtcgtg cttggtatat cctttgaagt tctgcagctg 2043301 acaaacaaag tgcgtgacat tcccggtctg aaattacttg ggtacccggg actttggctt 2043361 cagctgttaa ccacaaagga acctaaggat gaacaggttg aagttgccat cgaaagcttt 2043421 aacgaacttc tcagactcga agcattgtct gagcaaaatc agaagccttc tcacaacgtc 2043481 atctaaaatc cgttgccctg ctattacttt cggaggtgga cagttatgaa tcatcgtgta 2043541 caacctatta ttgctgtatt aattgcgctg ggagcgttcg gtttcctcta tgtgctggta 2043601 accaatcccg gagaaatggc aaaaatggcg gtaaccgtca tcgtggcagg tatcattatt 2043661 tattttattg tgaaatatgt aatgaatcga aatgcgggca gcgaaggagc agccttcaaa 2043721 aaagcggcga aacaatcacg gcgccggatg aaagaacaaa aagcaaaaca ccgcgccgga 2043781 cataagggac gtgtcagcca cctgcgaagc gttccgagcg ccagcaagcc taagccgatg 2043841 attctcaaga aaaaaagcca gactcagctg actgttatag aagggaaaaa aaataaaaag 2043901 aaaaacagag cgctttttta ataggtccac tgctttaaaa acagctctgt ccgtctttta 2043961 cctagctcaa tcagggctag ttttttttgt tgtgttaaat gaaaatcagt ggccattacg 2044021 tcatcaacag ggagaaaaat gatattttgt tcatagcgtg acgcaatgtg ccttgcgtca 2044081 tgagcatcct tcatcgtttc aaacagggcg ccgaacagtt caaaagcgtt gcggatattt 2044141 tttttcggac gctctctttc acgcggcgca agcgtgacac cgatcacagg gcgctttctt 2044201 tcctttgaaa acagccagat tggaaaattg cttaacacgc ctccgtcgac aaccgtggcg 2044261 gtgcctgtgt ccgtttttaa ttttatcggt tcaaagaaat acggaatgct gcagctcatt 2044321 ctgaccgctc tggcaaccgg gaacatatct ggatttaacc cgtaacgggc caaatcgtcc 2044381 ggcaaaacaa tcatggtgcc gtttgtcaga tcagaagcaa taaggcgcag agaccctttc 2044441 tgcaaatcgc cgaaaaccct tatgcctttc gctcttaaca gatcagcaat ccatttttct 2044501 atcgtatcgc ctttgtataa gccaagacgc cagtagatgg acacccactg gagcatcttt 2044561 aaggggagaa atgagtacct ctgatccagc aatttctctc cgtccacttc ttcaattaaa 2044621 gcgtggattt ccttactggt gtaacctgac gcaatgaaag cggcaataat ggcgccggcg 2044681 cttgtacccg caactctttt aaagcggaag cctttttcct caagcacttc ataagcgcct 2044741 gcgagcgcaa tgccttttac tcctccgccg gaaaacacac cgtcaatata catctcattc 2044801 cctccccctc catccgatcg tttattacca ttttaagaaa acacgcgaag aaatagacca 2044861 acgaatgacg ggtggcgtca gcgtatcaaa aaagacggcc tccttcgaga ccgccttttt 2044921 actgattatg atgttctgtt ttcttttgga ttgatttcag atctttttta cgggcatcat 2044981 cttcttcaaa atattgaaca agatccccga tgcgatcaat actgttccag cttaaatgat 2045041 gttcgattcc ttcgacatcg ttatatattt tctcttcatc aacaccaatg attcttaaaa 2045101 actgctcaag caattcatgt ctgtatacca gccgtttgcc tatttttttc cctttagacg 2045161 ttaacacgag accgcgatat ttttcataaa ttaaatattc gtctttatct agtttttgaa 2045221 ccatttttgt tacagaggag ggatggactg ccaatgcttc cgcgatatcg gaaactcgtg 2045281 catatccttt ttcttcaatc agcatataaa tctgttcaat ataatcttcc atacttggtg 2045341 ttgtcatcga aaccctccca aaaagcacct taactttata aaccattaca agtttacact 2045401 aatgaacttg aaaaaacaag gatgctccgc gggtcaaaag ccctgtttac cgcttataat 2045461 tccattcatc tgaagcgtac tttgtttcag ccaagtgatg aacaaaatca agctcttcct 2045521 gagaaagttc atatggctcc aaatgaatgt taagacctgt ttcaaatcct tctttaaagg 2045581 ctttacgagc ctcatccatc gtcacccgct tttcgatgag ttcattaatg gcaaccgctt 2045641 tatttttgaa attgcgctgc atccgctctc ttactctttc acttggatat aagaacagat 2045701 cgaacagctt gtcctcatct aaatcaagaa gaatggagcc atgctgaaga atcacacctt 2045761 tttgtctcgt ttgcgcgctt cccgccacct tgcgcccctc aaccactagt tcataccacg 2045821 aaggcgcgtc aaaacaaaca gatgaccgcg gattttttaa gctttctttt tctttttcag 2045881 ttctcgggat ggcaaagtaa gcgtccagac cgagatttct aaagccttga agtatgcctt 2045941 ctgaaataac ccggtaagcc tcagtaacag tcgccggcat ctcggggtgc tcttccgaaa 2046001 caattacgct gtatgtcagt tcctgatcgt gcagcacacc tctcccgccg gtcgggcgtc 2046061 tgacgaatcc gagattatat ttatgtactg cttcaaaatt gatttccttt ttaatatttt 2046121 gaaaataccc tacagaaagt gtcgccggat tccagccgta aaaacggata accgggggga 2046181 ttttcttttc gctgtgccaa tataaaagcg cttcatcaag cgccatattg aatgcaggac 2046241 ttgcattgcc tgagtctata aaccgccaag tttctttttg cattttaaga ccttccttac 2046301 cgttttaata gaatcagttt atcaaactgt cgggaaaatg aaaaatattt tagttccatt 2046361 atagatgaca atcacgctgt gctttactat aatagtattt gtcgaaaacg gctctatgac 2046421 cttgttttat gaagcagggt tttgatttta tatgctaaag gagtagaatc acattgtcta 2046481 atatgatcgt tttgattatt tttgctgcat ttatcatcta tatgattgct tcatatgtct 2046541 atcagcagcg aattatgaaa acacttaccg aagaagaatt ccgcgcgggt taccgcaaag 2046601 cgcagcttat tgatgttcgt gagccaaatg agtttgaggg cggacatatt ttaggcgccc 2046661 gcaacatccc gctttcccag ctgaaacaga gaaaaaatga gatccgtacg gacaagcctg 2046721 tttacctgta ctgccaaaac agtgtccgca gcggacgcgc ggcacaaacc ctgcgcaaaa 2046781 acggctgcac tgagatttac aacctaaaag gcggctttaa aaaatggggc ggaaagatta 2046841 aagcgaagaa ataaagcaaa cagctgtctg gtagacagct gtttttattt atctttcttc 2046901 cgcctcgtat ctgagcactg ggtgtctcgc cgcttttgtt tcatccattc tttttacaat 2046961 cgttgtatgc ggggcctcct gaacaagctc cggattctcc tccgcttctt ttgcgatttg 2047021 aatcatagca tcaataaacg cgtccagtgt ttcctttgat tcggtctctg tcggctcgat 2047081 catgatgcat tcttcaacat taagcgggaa ataaatcgtc ggcggatgat agccgaaatc 2047141 aaggagccgt tttgcaatat caagcgtacg cactcccagc tttttctgcc gcttccctga 2047201 taatacaaat tcatgcttgc aatggcggtc aaacggaaga tcgtaataag gcgcgagttt 2047261 tctcatcata taattggcgt ttaacactgc gttctcagta acagccttta atccgtcagg 2047321 ccccatggag cgaatatacg tatacgctct cacattaatg ccaaagttgc cgtaatacgg 2047381 cttcacacgg ccgatcgcat gagggcggtc ataatcaaac gtaaagcgcc cttctttttt 2047441 gactaaaact ggctttggca aataaggaat cagatcttgt tttacgccga cagggcctga 2047501 gccggggcct ccgccgccat gagggcctgt gaatgtttta tgcaggttga ggtgcaccac 2047561 gtcaaatccc atatcaccag gtctcgcctt gcttaaaacg gcatttaaat tagcgccgtc 2047621 ataatacagt ttcccccccg cttggtgtac aatttccgcc atctctgtaa tctgctcctc 2047681 aaacaagccg agcgtgttcg gattcgtcag cataagagct gcagtttctt cattcactgc 2047741 tctttttaaa tcctctaaat caacaagccc tttttcattc gatttcaccg taacggtttc 2047801 aaagcctgct actgttgctg atgcaggatt cgtcccatgc gcggaatcag ggacaatgac 2047861 cttcgtccgc ttgaaatccc cgcgagcttc atgataggca cggatcatca tcagccccgt 2047921 ccattcgccg tgcgctccgg cagcaggctg aagcgtaacc tcatccattc ccgttatttc 2047981 ttcaaggtgt ttgcttaaat catataaaag ctctaatgcg ccttgcaccg tgtcttcatc 2048041 ctgaagagga tgaatcgcag caaaaccagg aatacgtgcg attttttcat tgattttcgg 2048101 attatatttc atcgtgcaag aaccgagagg ataaaaaccg gaatccaccc cgtgattgcg 2048161 tttggacagc gctgtataat ggcgcatgat gtccagctct gaaacctccg gcagcgctgc 2048221 gtcttcgtca cgaatatagg tgtctgacaa gaggtccccc aattcgattt ccggtacatc 2048281 gagctccggc agactatagc cgattcggcc ttctcttgaa agttcaaaaa taagtgcctg 2048341 gtcctgatta ctcatggcga tcccccaatt cctgaatgag tgcgtcaatt tcttcttttg 2048401 ttctcagctc tgttacagca atcagcatat ggcagtccag ctctggatac gtcaacccaa 2048461 gatcatatcc gccaatcatg ccttttgcca gcaaacgctt gttcacagct ctcaccggct 2048521 catccagttt gatgacaaat tcattaaaca tcggcccgtc aaacataaca gtaaggcctg 2048581 ctttttttgc ttcttgcttt gcatagttgg cttttaagag attttggcgg gctatatctt 2048641 ttacgccgtt ttttccgaga gcagtcatgg ccactgatgc tgccagcgca tttaaagctt 2048701 ggttcgagca tatatttgat gttgctttat cccggcggat atgctgctcc ctggcttgca 2048761 gggtaagcac aaagcctctt tttccgtttt cgtcttccgt ttgtccgacg agacggcccg 2048821 gcacctttct cattaatttt ttagtaacgg caaaaaagcc gcaatgcggg ccgccgtatg 2048881 ctgaaggaat gccgaaaggc tgcgcatcac cgacgacgat atcagactga aacttgcccg 2048941 gcggagtgag aagacctagc gccagcgggt tggctgaaac aataaacatg gatttccctt 2049001 gatgagcgat aggctcaata tcctttagcg gctcgatcct gccgaaaaaa ttcgggtact 2049061 gaacgatcac tgcggctgtg ttctcgcaaa cggtttggcg caatgcatca agatccgtaa 2049121 cgccatccgc agcgggtact tcaacaacat caatatactg accttttgcg taagttttca 2049181 gcacctctcg cgattcagga tgcacggttt ttgacacaac aatttttttc tttttcgtgt 2049241 ggcctgaagc aagcattgct gcttctgcca aggctgttcc gccgtcatac atcgaggagt 2049301 tggcgatatc catgcctgtc agttcacaga tcatcgtttg gaattcaaaa atagcctgga 2049361 gctctccttg tgaaatctct ggctgataag gcgtatatgc ggtataaaac tcagagcgcg 2049421 aaatgacatg atccacaatg acaggctgat agtggtcata tacacccgct cctaagaaag 2049481 aagcgtattg tacggtatca cgatttttag aggccagctt tgtcagttct cttgttaatt 2049541 ctgtctctga tttcgctttt ttgatttgat gctctttttt atatttgacg ttttccggta 2049601 tatcagcaaa taaatcatcg atgctgctta cgccgatagt agcaagcatc tcctgtttat 2049661 ccttttctgt tgcgggcaaa taacggtgct tcatgtgttg tctcctctct ccaagaaaaa 2049721 atattagcgt ttataaaatg gtgttttgac aacctttgct ttcactaatt ttttgcgtat 2049781 ctctacatct acaacagtcc cgatctcact cgtttccgaa tcaattaagg caaggccgac 2049841 gttttttcct aatgtcggtg actgcgtgcc ggttgtcacc tttccgacag acttgccatt 2049901 ttggaaaacc tcatatccgt gccgcggtat ccctttttca atcatttcga gaccgacaag 2049961 tttgcgcttc gctccgtttt ctttttgttc actcaatact gacttaccga aaaagtcaga 2050021 ctcctttttg tgctttacag caaagcctat acctgcttca atcggtgtaa tatcccgggt 2050081 cagctcctga ccgtagagcg ggagcttcgc ttcaaaccgg agtgtatcac gtgcaccgag 2050141 accgcatgga atcaatccgt atgcatcccc tgcatcgatg atttttttcc aaatatgcat 2050201 agcatcatca ctgcggcagt aaatttcata cccgtcttct cccgtatagc cagtgcgtga 2050261 aataagtgct ttgcggccgc tgatatcggc ttcatcaata aacgcaaacg gctttaatgc 2050321 agacacatcc gcatctgtca gattttttaa gatcgcttct gctttcggtc cctgtacagc 2050381 caagagcgcg atttgatctg actgattgtc aatctgcaca tcacctgctg catgttcttt 2050441 catccaagcc aagtctttat ctatattaga agcattaatg acaagcagat agcggttctc 2050501 tcctttttga tagataagca aatcatcgac ggttccgcca tccgggtaac acatcgctgt 2050561 atattgagca cggcctggcg ttaacgcgga aacatcattt gtcatcaatc tttgcaaaaa 2050621 agacagactg tcgttccctg acacttcgac ttctcccata tgagatacat caaacaaacc 2050681 ggctgcagtt cggacagcct cgtgttcttt ttttatagaa gaaaattgaa caggaagctc 2050741 ccagcctccg aaatcaatcg tttttcctcc atattcctta tacaggtcaa ataacggcgt 2050801 tcttttcagc atctaattcc tcccctttat caacggcgca gctaaaaaac atacaaaaaa 2050861 ggacagagaa acacctcatg taaaatgaag gttctctgtc ctggcacctg aaagtttact 2050921 ttgcatacgc aaagacgtcc cctttggtgg tttgcgcatc cgcacaaaca ctctccagag 2050981 ttgcgtcgag caagagttct tttgcctgag agattcactc cgcagtttgc tccttcggcg 2051041 cctgtatccc gaggttttcg gtcaggtctc tccccttgct gtcattcgct catattttca 2051101 tgctgttatg gacatactat agcaatatct tacatcaaat acatactcat atcctaccat 2051161 catcactata tgctgggcaa cagcaatttg ggcagatttt tcttatatta ttcatcttaa 2051221 gaatcgaaga ataagaaagg cggtttcaaa gcaatgaata cagaaatgat ctacgatgca 2051281 aaatggcctg aagaatttgc tgaaagactg aaaaacgatg gcccttgggc aaactgggaa 2051341 ctgtacaagc tctctgcaga aatccagaaa acattagcaa ttccagagtt tgaaggctta 2051401 cgggctcctt tatatctgcc ttcctttacg ccgctccccc accagcttga agtggcgcaa 2051461 aaagtggttg aaaaaatgaa cgggaaagcg attttagcag atgaggttgg tctcggaaaa 2051521 acggttgaag ctggactgat tctaaaagaa tatatgattc gcgggttagc aaaaaaaatt 2051581 ttgatccttg tgcccgcttc ccttgtgtca cagtgggtca aagagcttca ggaaaaattt 2051641 ttgattccgg ctgttgaaca aaagaaaagc tatgtgtggg agcaatgcga tattgtcgtc 2051701 tcatcaatag acaccgcgaa gcgctcgccc catcgagaaa tcgttctgtc tatcccatat 2051761 gatcttgtca ttattgatga ggcacacaaa ctgaaaaata gcaaaacgaa gaactatgaa 2051821 tttgtccgga atctcgtaaa aaaatattgc ctgcttctta ccgcgacgcc aatccagaac 2051881 cgtatcgaag agattttcaa tttggtgtcc ttattaaaac ccggccattt aggcagtcag 2051941 aatcactttc aggaggagtt cgccaagaag aaatccagtt tagaagcgca tgaacattta 2052001 aaagatcttg tgaataaagt catgatccgt aacaggcggc atgatacagg gctgaattgg 2052061 aaacagcgcc atgttgaaac agtgccgatt caattttctc catcagagca ggcgctttat 2052121 gatgaaattt ctcgtttgaa ggacagtatc aataaaccag ccagcatgtt ctcgattatg 2052181 accttgcaaa gagaatgctg ttcgagcaga gaagcggtat atatgacgct gaaaaagatg 2052241 cttgatcaaa aagagaaaca agcacctgcc attgatgagg atacgatttc agttttgata 2052301 gatcgcatca atcaagtgac acaaaactct aaagcgcttc aagttgttga cttgatcaaa 2052361 aagatcgacg ataaggtcat catttttaca gaataccgcg caacccagat ttatctgcag 2052421 tggtttcttc agcaaaacgg catcagttct gtgccgttta gaggcggatt taaacgtgga 2052481 aaaaaagact ggatgaagga tcttttccgc ggaaaaatcc aagtccttat tgcaactgaa 2052541 gcaggcggtg agggaattaa cctgcaattt tgcaatcaca tgatcaacta tgacctgcca 2052601 tggaacccga tgcggcttga gcaaagaatc ggaagaattc acagactcgg gcaggagcgt 2052661 gacgtgcata tttataacat ggcgacaaaa catacggtgg aagagcatat tctaaagctt 2052721 ttatatgaaa aaattcattt gtttgaaaaa gtggtcggtg aacttgatga tattttaacg 2052781 aaaattcaag tgaacaattt tgaagagcac cttcatgaca ttttgtatca ctcagcaaca 2052841 gaagaagaaa tgaaaataaa aatggataac ttaacctcat ttttgtctta taaaaaacag 2052901 ctgcctgctg aaaaaagagg atcttagcct gtaaggaggt tttattagtg agacagcaag 2052961 aggttcacga ttttctgctg cgtttttttc aagcaaacag ctgccaaatc gtcgatcaag 2053021 gcttaggcta tatgacagtg cagcttacag ttgaaatgga caaacaaatc atgaaccgcc 2053081 ctttctactg gcattggcgc gagaagacag gcggtgatcc gaatccaatg aaaatcactt 2053141 ttattacaga taaagaaaat gcgccaaaag acctagatgg tgaatttata tattttgggg 2053201 ccccgcgtct ttttcaaata ttcaaagctg ttaaacaaaa tgggagattt accagaatgt 2053261 atgagaaaat tgaatcagcc ggagctaaag tcccacttca gccttggctt ggtataaatg 2053321 tcacgatttc ataccagtcc gacatgaaaa aggataagtt attgtcacta ggtcttcacc 2053381 tagtctctgg aacgataatt gaagattttc aaagcaagct gacccagttt tcactgacgt 2053441 ctcaaatatg tgactattgc ttcaccattt cacctatgat caaaccagaa agcggactta 2053501 agcgtatgga aaactatatt tccaaatccg ctatgcagga gccgtccgac tgggcggaac 2053561 aggcggttaa caggtggaag aatgatatga cattgcttga taagttttac gagcatatag 2053621 aagaaaaacc agaagaatac catctagaaa aacaggcgct gaaaaccttg tatcaaccaa 2053681 agatatcagt tgaaattgaa aatggcggat tgttttatct gcaaaataat atttcaagct 2053741 aactttttta ccattcgaca tcattctcgt tttttttgag aaaatacgat tataataaag 2053801 gtatattgga aaaaaattct ggtgatttaa tggcaaatga cttccagaga ctaatgaagc 2053861 atacaataag tcatggccgg actggctgaa atacataaac aagtatttta ggaggagaaa 2053921 ctgcatgaag aatgcaaaac aagagcactt tgaattggat caagaatggg ttgaattaat 2053981 ggtggaagcc aaagaggcaa atatcagccc ggaagaaata cgaaaatatt tacttttaaa 2054041 caaaaagtct gctcatcctg gtccggcagc cagaagtcat accgtaaatc ctttctgaat 2054101 gtgctataat atcacaagga aggtgatgac attgattggc cagcgtatta aacaataccg 2054161 taaagaaaaa ggctactcac tatcagaact agctgaaaaa gctggggtag cgaagtctta 2054221 tttaagctca atagaacgaa atctacaaac gaacccctcc attcaatttc tcgaaaaagt 2054281 ctccgctgtt ctggacgtct cggttcatac tttgctcgat gagaaacatg aaaccgaata 2054341 cgatggtcaa ttagatagtg aatgggagaa attggttcgc gatgcgatga catccggggt 2054401 atcgaaaaaa caatttcgtg aatttttaga ttatcaaaaa tggagaaaat cccaaaaaga 2054461 ggagtagtgc ctgagcagag gcactaactc ctcttttgtc aataaccatc gagacggccc 2054521 agtatatgaa tactgggccg tctctttttt ttgctgttat taatttttat cctcgctatg 2054581 cgcgagctcg tcttgctcag tattgctcat tttttcaatt ttttagaaat ttttgggatt 2054641 gttatgtgag aatttaaatg catatcccat tattatttgg taataataaa caaagaaagg 2054701 gtgacagcat gatgatcaaa caatgtgtga tttgtctatc tcttctcgtc tttggcacca 2054761 cagccgctca cgcagaagaa acaccgcttg taaccgcccg ccacatgtcc aaatgggaag 2054821 agattgctgt aaaagaagca aaaaaaaggt acccgctcgc acaggtactg ttcaaacaaa 2054881 aagtatggga ccgtaaaaga aaagatgaag cagtgaagca ataccattta actctgaggg 2054941 aagggtcaaa agaattcggc gtttttgtga cgatttcatt tgatccttat agccaaaagg 2055001 tcaataaaat tgccatatta gaagaatatc aataaggtcc tccatttttt gaaggacctt 2055061 attcgtttat ttgcggttat tttttccgtt tcagccaaag tcggaagcca tagggtaaaa 2055121 taccgaacca ctgctgggaa acaggcgttt ttgtttcttt ccgcacctct tttcgttctt 2055181 ttcgctcatc tctcggagta tctatatatt tgacaaattg ctgcgtcata tatttaacat 2055241 aatcattcgt tttcacgtga tcacctcatc attcaattat tatgagtgtt gtctcacatg 2055301 acttttttta taccctttac actgttttat tctgtccatc tcagcagttt tttctgtttt 2055361 tggtcaaaca cgatctgtgc agttctttct gttcccgaat ccgttgacac tcttaagttg 2055421 atttcttttt gttcttttat cgatgtatca tgaatgtaat aagaaacccg tccatataga 2055481 aattgctgcg taccctcctg gcctttccgt tcctctagaa catgccgaat cgaaagaagc 2055541 accccatttt gaagcaaatt ctctcctatg tataactctt ttgtttcctt ctcaaacatg 2055601 cagcgtgaaa tatattgagc agcaacaaag ttcacgatta acagcacaag cgctgacaca 2055661 aaaagaacag ctggataaat aaaccctctt gtacgataca ttcacccccc tcctaaatac 2055721 gaatagactg gaaaagcagt ttgatacact ttttggtctt cactctcaat tttcagcaaa 2055781 acaacaccat tttcaatatc agctttcatg gcagtaatat gatctaaaat cggaacatgc 2055841 cctttgccat ccactctttt tcttatcatt gaatgataaa tgtcaaaacg gatgtcttgt 2055901 ccggaaagat tggtgcagat taacacgctc ccatgctcgg ctgtcttaac tgcctgtgat 2055961 tccttgcatt cattcatcat ctgttctatc gaaatcatcc attcctgctg tgtgaaaccg 2056021 tcatgttcct gctgtcgaga caaaaacaga tggataatcg cagctaacga tcctgatatg 2056081 agcaaaaaga ctgagagcga aaataatacg ttaagaagcg tgtagccatt ctgtctgcaa 2056141 aatgctgagg caaaatgatt tttctttata agctgcggct ttgatacata cgttttgata 2056201 ttcgccctcc tcctcccact tcattgcata gatatgattg ttctttgtaa tcgtttttga 2056261 cgcggctcct tcaccactca tgacatattt gctaatgctc tcattcatca tctgatagcc 2056321 aatttctcgt gattccgcca ttttttcatc agccatcagc ttgtcccaca aggggacgac 2056381 tgtcagcagc acaaacagcc acaggcttag cgcagacatt gtttctattg tagaaaaacc 2056441 tttattttct ctccacattg actctcccgc tccctagata aactgttatg tcataaacgg 2056501 catggccttt tactcgtatt tttccgcctg cattcgggtg ccctttctca ttaaattcca 2056561 aacggtcttt taatgtcagc agttctatag aaagtcccgt tgcatacgga cgttcaataa 2056621 ccgtatcacc aatgactaat tgatattctt ttttatgaaa gagaattttt gttctttgtt 2056681 gacgggaaat agcagtctgc tgtgtgagca taatatcatt tttcagctga cttgctgcct 2056741 gtcggacagc tgtattgtca taagcaggag gaagtgtagt gaagacggcc accaggagga 2056801 tagaggcaag gcttaacaca agcaaacttt ctaaaagggt aaaccccttc tcctcgttta 2056861 atttaatgtt caaccttaac ttctccgccg gtgatgataa tgcgcttacc atttggacag 2056921 acagcatcct ttttcacata gccctctgac tgtaaatcgg caaggctcgg agtttgtcct 2056981 tcatgatcaa gctcaaatgc agtcatttgt gccttaacca tgttttgtaa gccttcacag 2057041 cccttttttt gaatggtttg attatgtttc gtgacgttcg gtatcgtaat taaaagcaaa 2057101 atcgaaataa taaagagcac gattaacatt tcaacaagtg taaatccttt ctcattcatc 2057161 agcctcttcc tttcacattt gattcatcat ctgatacata ggcacaagca tagataaata 2057221 cacaagtaag atcatcgctg caacaaatcc ataaatcatt ggctgaagga tgcctgtcca 2057281 tttttgcgct ttgtgttcca gccgctgtaa tatgaattgg ctgtatgtga aaagctcccg 2057341 atccaatcgg ccgctcagct ggccgtgaga tatgactttt gataaatcag tttcataaaa 2057401 aaggcttcca caaatagcgg attcaattga ctcaccggct tttagccgtt caatcaattg 2057461 ttcagcctcg cagcggtaga aagggagaaa cgtttgatgt ttaaatgcat taaggctgtc 2057521 ataaattgag aggcctgatt ttaaaaggct gcttagctgc aaagaaaaaa agtagctgtt 2057581 aaacagcttt acaagctttc caaccaaagg aatcctgata caaatcagca tttgccgggc 2057641 aggtgatttt ttcttaaaca caagccaata ataaatcccg atacctgctg taaaaagaac 2057701 aagcaaaatg atcacaagat caatatgctg aaaaaaagca aaaagcatat cggttgaacg 2057761 tgaggtttcc atattcatcg attgatagat accggaaaac tgaggaatga tgatggactg 2057821 taacatataa aacatgacag cgaccgtaaa gatgaggaaa agcggatagc gcagcactct 2057881 tttcagctgg tctgcctgtg caatttttcg ttccagcagc tctccgctct ggatcattga 2057941 agcaggcagt tcaccatgtg tttcagcaaa ataacaaata cctacggctt ccttatgaaa 2058001 tgacaaactc tttagtactt gataaaacgg agccccttcc ctcaaacaag tgaccgaatc 2058061 agtcaagtca gccgcctgcc tcttattcat ctgaagttcc atcaggcgta atccatccag 2058121 aagtgtatat ccgcccgcag tcatttcacc gagcctcttt aataacctgg cttgatcctt 2058181 taacaaccag acttttctaa tctttttcat gataaaccca ccggtcatag ttgtttgtcg 2058241 ttaaatagcc gagcgcaatt ccttttctga taatttgacg aagcgtttga tattggtaat 2058301 ttgcatgatt tccttttgcc tcctggatac attgctgaag atttttcccg tatagaagct 2058361 cataaacgct agctctccta gtatttcgtg actgtcggca atacactgat gaacatccgt 2058421 tttcacaaaa cgggcaagcc aaatcaacca agcgctgagc cgctattgca atgacagtct 2058481 gttcgatttc attcatattg ataccgaatt caagcagtct gtaaattgcg ccctttgcgt 2058541 ctctcgtatg aaggctcgtt agtaccagat gtcccgtcat cgctgcccgc accgcaattt 2058601 cagctgtttc cgcgtctctg atctcaccta aaataatcat atcggggtca tggcgcaaaa 2058661 ttgctttcag acctgcggaa taagttacac cggctttttc attcacctga acctgaagaa 2058721 catcttcgtc ccttgtttca acagggtcct ctaatgtgac aatatttcga ttaaagtgtt 2058781 tttttgcata ttgaacgaga gagtataatg tggtagtctt ccctgaacca gtcggcccgg 2058841 taaaaatgag catgccatgg gaatgtttta aaaacgagag taatgtggct cctgtcttcg 2058901 gaaatagcga caatttatca atcgaaggga tattgtattg gggcatcact ctgatcacga 2058961 ggctttcttc attaattgtg ggcagcgttg acattcttaa atgaacattt ccctctttca 2059021 actttaacgt aagcgaaccg ttttgcggct ttcgcctttc acctatatcc attgctgaaa 2059081 gaaatttaaa atgtgaaatc agtcttacgc actcttcttt tttcatgtcc ctttttttca 2059141 gcaaggcatg atcgacccga aaatgaatga tagcgtcccg ctccctcggc acaatgtgaa 2059201 tatcagaagc ctttgttaga tatgcctctt caatcaagtt tttgcttacc ttttctattg 2059261 aatccaattt gattccctct cctttcaacg catattgtag aaaaagaaga aaaggtaatc 2059321 aaacagggaa aacgtgattt tgtgagatgt tatatgctga aaaaccaatt ctttctggca 2059381 agaaaaaaga ctttcaactg aatgtacccc tgtcattata attttcccta taaataaaaa 2059441 agcagacatg gtcaccatgc ctgctagatt ccattttcat tatgctgttt tcgcttattg 2059501 accagtatct ttctcaacgg aaagatcgcc taatgcaaca ataccggtca tttggtcatt 2059561 ttcaagaatc gataaactgc ggatttaatg ctctgtcata agccccttga catcgtatcc 2059621 ggtcaccctg atatgtctgg tgaaaaagcg gggcacgctg cacaaaatat gaaacatcct 2059681 atagagtccg cctttttcga ggtttctttt tcttcttccg ctcctgcagc atatctcccg 2059741 tccagccttt ttttctcaaa tagagataga tcagaactgt agatgtgaca atcaataaga 2059801 gggaaaagag atatccgtat ttccaattca gttccggcat cactgaaaag ttcatccccc 2059861 ataaggcacc cagagctgta atcggagtaa aaagcgtcgt gaaaatggtc agcgctttta 2059921 caatttcatt ccccctatgt gaggtaatga cttcctctga atgcagcaga ttgttaagct 2059981 ccccttcaaa ttcgctgatg tatgtaaatc ccctgtcaat cttcagttgt gtccgctgat 2060041 aatccttttt cccttcattt tgaggtaaaa aggtttcttt caacgccatt tcaatttttt 2060101 tagcgcttaa tatcaaattt ttccaaatca tcagttcatg gcgcaggaga tggacgcggt 2060161 ttaaaatgct tttgctattg tcgtctttaa tttgccatct gagctttctc agcttgactt 2060221 caaattcatc aacaccgatt aaatacgcat tcattagttc gccgagaaga attaaaaacc 2060281 cctctatcgc attgtccgct ctttccattt gccgaacaac ttctttgcct ttaatctctc 2060341 tcaaaattga aaagtcaaag ttgattgtaa aaaaatattg tctggtgata taaaagtgaa 2060401 aaacagtatg gtctttttct tcaccaagcc cctgatcata aacaatcgac ccaaatactg 2060461 cttcattttc cgtttcagtt gtatctactc gcaaaaaatt aacgtgatgg ttattttcaa 2060521 accacttttc acactgaggc cagtgagaaa aatggattag atctcttgcc ttacttcttt 2060581 cttgaggccc catttggtac caaaaccaat cctttcccgt atgtgccttc atgtcaagct 2060641 cctccaaact tttgttcttt attctttaat tgcccaataa ccgcgtcact aaaccagtct 2060701 gccgcttcaa cacatgtttt atgagcattt tcaggtggta tggaatgtag aaagacatcg 2060761 gaaaagggag gtgcatgcct tccttggaga aggcagttgt tttggaattt atcaatttac 2060821 tagcagtcgc tattctcatt ttgttaacag gatttttcgt tgccgtagaa ttttcaatcg 2060881 taaaagtgcg gcgatccaaa attgatcagc ttgtcgcaaa aggaaagaaa ggtgctaaag 2060941 cggcaaagca tgtcatcact caccttgatg aatatttatc agcctgtcag ctgggcatca 2061001 cagtcgcagc tttaggactg ggatggcttg gggaaccgac tgtgcaaact ctgcttcgac 2061061 cgctttttca taaagcaggc ttaaatgaat cgcttaccca cctgctttca ctcgtcatcg 2061121 catttttagt ggttacgtat ttaaatgtcg ttattgggga gctggcgcca aagagtttcg 2061181 ccattcaaaa agcagaaagc attaccttgt tgttcgctaa accgcttatt tggttttata 2061241 agatcatgtt tccattcatt tggctgttga accactctgc ccgattgatt acaggagtgt 2061301 ttgggctgaa gccggcatca gagcatgagc tggcttatac agaggaagaa cttcgggtcc 2061361 tattggctga aagctataaa agcggcgaga tcagaaaaag tgaattaaag tacatgaata 2061421 atatcttcac ctttgataaa cgaatggcaa aggaaattat ggtgccgcga aatgaaatgg 2061481 ttagtttgtc actagatgaa gactccattt caaatcttca ggaaacagtc aagcaaacaa 2061541 aatatacacg gtacccggtt gtaagagagg ataaagataa cgtcattggc gtgattaata 2061601 tgaaagaagt gctgttttcc atgctgacga aagatttttc aatcaagaag catcaaattg 2061661 aacctttcgt acagcccgtt atccatgtaa ttgagacgat tcctatttat aaactattgc 2061721 tgaaaatgca aaaggaacgc actcatatgg cgatcctcat agatgaatat ggcgggacgt 2061781 ccggtttggt cactgtcgag gatattatcg aagaaattgt aggagaaatc cgtgatgaat 2061841 ttgatgcgga tgaagtgcct catatccgcg aacttggaaa ggatcattac ttgttaaatg 2061901 caaaattatt aatcagcgat gttaacagcc tgcttggaac cgatttatca gaggctgaag 2061961 tagacacctt gggcggctgg tttttgacac aaaacataga cgctgagcct gaaagtgcca 2062021 tagaatatga tggctactct tttaaggtaa aagacatcaa cagccatcac attttattta 2062081 tagaagttaa aaaagctgaa tagcccgtga aaggctgttc agctgctatc tttcaagata 2062141 aacatggcaa aggcatcaac actcttttat tttaaaccct ttattggcca gggctttagc 2062201 aagactttgc tctgttttca cattcgaaaa atccagaccc agcttcacga cagtttgggc 2062261 aatttccggc ctgattcctg aaataatagt ctcaatgccg agcaatttgg tgctgtcaat 2062321 cactttaaaa atttgatagg ctaccatggt atcaacgata ggaacgcccg aaatatctaa 2062381 aaataaatac gagagcttta acgctgagca ctgctccagc acagactcca aaatcgtcct 2062441 cgctctgtgc gtatcaattt caccgacaag cggaagaatc ccaattccat cagtaatcgg 2062501 cataatcggc gcactcaatt cattaatcat ttctttttgc gcgtttaatt gtatcatggt 2062561 cacctggtga tattcttccg taaacacttc gatgatctca tcaatgtttt gattcaagat 2062621 ccggctccac tcataaaatt cctgaatgct gatgtcttga gaagaagctt cgctgaattt 2062681 atgaatccat tcaaacatga tgtgcctgaa agtgttaaac tggccgacac tttgtgtaac 2062741 cgtcacttca tgaacggcac ggtctctggc gcattgaaga gaccaccggt tgagctcatc 2062801 ctctacgtct tcttttctaa gggattttgc tacgatggtc accaataatt catgctggtc 2062861 ttttaacttt tgttctagtt tttgctgatc tttcgctgaa tacagccagc tgccgtttga 2062921 cgtacaaact tccagccatt gttgcgtaat atcttttttg tgctctgtta agtgctgatc 2062981 aagagctatc atcttaatga gttacctcct gtttttgaaa aatgtacgct atatatgtat 2063041 aacgcgtctg cctttacaca tactatgttt agattcaatg ggctatagcc aagcggtaag 2063101 gcaatggact ttgactccgt gatcgttggt tcgaatccag ctagcccagt ttctgaacag 2063161 gtgaaaaacc gaagataagc tgattcgtat aaatcagcgg atcttcggtt tttcatcatg 2063221 cagattgatg aaccgttttc ttcttcgata acttcaacag ttctcccggg ttataaccaa 2063281 tcaccagctt tttgttgtct actagaatcg ggcgtcgcaa aagcttcggc ttctcgatta 2063341 aaagttccag cacctcattt accgtcattt cttcaatgtt taaatttaaa tttttgaaag 2063401 tctggcttct tgtcgccaaa atttcatcaa ttccttctgt cgttaacgat aaaatgtact 2063461 ttaattcttc tcttgtcggg gtttctctga ataagtgccg ttcgttaaat tcaatttgat 2063521 gtgctttaag ccaatgtttt gtttttcggc atgacgtgca gcttggatat gagtaaaaag 2063581 ttaattgttg ttccattcgt tttttcctcc tcagttaacc atctctttgt agaataacta 2063641 cccggatcat ttttcattta aaccatttac agaacttttt tcggattatt ttttaaaaaa 2063701 cattcataca atagaaaaca caatcaaagg gacaaattcc atttgtatat taataatgaa 2063761 aatgtttaca tttctaggtg tgatctatta taataacagt cagagggact ctcgggaggg 2063821 gataaaaatg aatcgcatgt tccgggtgtt aggattttgg acgggaattt ttgcagtcat 2063881 gttttattta ggtgatatga aagatgcttc ccttttattt tttggacaga cgatcttatt 2063941 tgtgtttcta tcgtatttga acttaaccga acgcatgtat atttatattt ttggcgctta 2064001 tttaacaatt ttcttcgccg gctttacata ttactcaatt tttattatgg tgcccggcgg 2064061 cggaggccat taaatgcaga aagagacaaa ccttatcggt ttgtctcttt ttttacaatg 2064121 aaaacccatt taaaaacgga ttttgatcct gctcagtcag tacgtctgtt tcaggtccat 2064181 ggccgcttaa caccagcgtg tgttccggaa gcgtaagcag tttttcatga atggacgtca 2064241 gcagcgtctc ttgattgccg cctattaaat ccgtacgtcc tataccgcct tggaacaaga 2064301 catctccgga aatgaccaag tctgcatctt tcacgtagta agacacactg cctggtgaat 2064361 gtcccggcgt aaataatgtt tccaaatgaa acggcccgat attcaactca ccgtcgcctt 2064421 caattagatg atctgcaggc ttagctgtga cttctatccc tcgcagcatg ccggagccgt 2064481 ttaaagaagc gtccgcaagc caattttttt cattttgatg caggtaaaca gggatatccc 2064541 atttttctct cacttcatca agcgccccaa tatggtcaaa atgggcatgt gtaagcaaaa 2064601 tggctaaagg cgtcagccct ttttctttta tgtattgatt gattttatgt ccctcgccgc 2064661 ccggatcaaa aatcagacat tgatcatcac tgatgagaaa atatgcgttc gcttgaatcg 2064721 gccctactgg cattcgtctc catttcacta ttatcacctc tttctttttt atgctcttat 2064781 tatgagggtt tttgaaaaaa gattcaaaca atcgcaatga aaacgctatc gacaaaccta 2064841 taaaaaacag gtagaataaa actggaaaga attgcaggtt tttcaatgta aagggggctg 2064901 tgttatgtta cttgtcgtga ttttcggcct tgtcgctctt ttcgctttat ggggagtctt 2064961 gcgttctgtt agaaataaaa atatactcgg gtttttatta gccggtgcca ccttatttgt 2065021 ctttggatgg tttaccgtga tgaccgtaat aaacagcggg tatccaaccg cacattaaaa 2065081 cctgtatccg atcggataca ggtttatttt tatggctgta aatgtttatt gacactttct 2065141 attttgctct caagcgtcgt ttttttgtca cgcctgtcat cgatacggat attcgttgcc 2065201 actctgtgca atcctttttg aaatggcgct tcgtgaattg cctgaataac tgcaaaaagg 2065261 tcactgagtt ctccctcgat cagcgtattc atcggtgtca gctgatattt gattttccct 2065321 tctgcttgat atccttctaa tatcttttgc acatcggcta cgtaagcact gacactgggt 2065381 gtttccgtac cgattgggat aatggttaca tctgcgatag ccatcgttat tccatctcct 2065441 tttgatcaat gatgagttgc ttcgtttcat gtgatttcaa taaaataatt tgctcaaaat 2065501 gaaagccgta taacgcatat ttcccgttcg gagatatttg aatcggctcc atttcccgca 2065561 gagacacaag atcttttgtc tctcccgatg ctacattgat tgctgcgagc ttatatgcat 2065621 cgccgctttg tttgaatgta taaaacaggc ctcctgcttc atcatagtca tactccattg 2065681 gagccaaact tgtatatttc gcttggagcg gccatttcgc tgtaacaggt gatgttgatt 2065741 gcggcgtttt aaactgatac gtcccttttc ctccggaagc tgatttgaca gtaaaactca 2065801 tttgatggaa agaatcgaag aatagaacgt tatcctcaag cttctgttcc gtcttagaag 2065861 ctgtatcgaa cgtatataaa ggccctgttt tatcgtctct accctctttt acataatcaa 2065921 atgtattttt ggatgtccaa tgaatgaacg gaacctgtac tgggcttaag aaagattcgt 2065981 cttttttagc attcacctga tatgtatgga aatcccagtt ttcattgaat tccgtcacca 2066041 tcatttgata aggatcatac tgattccaag cagcttcaag ctcatacgtt tcgtaatctt 2066101 tttcgtaaag cgtctctcct tctgcattaa gcaaaaccac tgccgtcttt tggctatgtg 2066161 tgatttgcag cagaatcatc tgctccctcg cattgatttg aacatcaacg atttgaccat 2066221 ccgtttgata gagctttttc gctttgcctg taaagatgcg gtacgcaaaa agctctgttt 2066281 tcgtcggatt agacgcagta tataatattg tgctgttatt cagccagcct tccgccccat 2066341 ccgctttttc cgcggaaagc ggtatgatgt cttttttctc atcttttgcc gccgatgcct 2066401 gtttttgctg ctgatgagat ggttcgcatg ccgataaact aaacagcaat accgccagca 2066461 gaataaaaca aactgatctc atcagcattc ccctccgatc atctttattc tctcatattt 2066521 gcttcggcag aaaaaagaaa aagtttcagt tactcatgaa aaaataacgc cctccacaag 2066581 ataccgcttg tggcgttata tatgtgtgaa aactgctgaa acggcaaagg attttggcct 2066641 tttccaagtt ccaccgtata cccttcctta aaataatggt gaataaacca atcacgaaat 2066701 ccagcatagc tgtctatatc ccttactccc ttataaatgt tcccgcttaa ctcctcaaac 2066761 tcctttatga cggcagcaga ttcctcaggc tcaaggcctt tatagcccca ataaatttct 2066821 tctccttgag tatgaagagc cagcagtctg tcaggcggat tctccgtgat cagccggtac 2066881 atcgcaatag attccggctc cgtaagcgga gagattcccg gaaaatcgcg gtagctgggt 2066941 gctgtcggtt ttcggtattt ttcaatttcc cataatgatg gaaattgttt atttaaatca 2067001 accccgttta tattcgcctt ccattcatta aaatttggac gatgttcatt tagcctttcg 2067061 agttcatctc ttctggctcc catgacttct gatccgttta aaacaagatc aacgccatcc 2067121 ggattgacaa gaggaacgag ggataaggat gtgctgttaa acagctttat gggagaaaag 2067181 ccaaagaaag gcgaattgca gcataatgac atacagtatt ccttaaacca ttttagcagg 2067241 acagacgttg taatccactc attcgcatga aatgacgcgt tcatatggac cttttttacg 2067301 gcatgctccc caccagcctt cagctcccag ataggcctgc cgagtacaga acggccaatt 2067361 tcccggcatg agacaaacgg aaaaacatca ataatcttct ttatttcctt ttcaacagct 2067421 gaatcatcat agattttctc ttgctcaatc cagctatctg aaagtttcag ctgccgaggc 2067481 tgtaaaaagc gctttatgtc ctgaatggtt tgaagctctt tgccgctatg ctcctctatc 2067541 acataaccag ggcaatacaa ttgatgtttt tgtgcggagc gatttgcact tttaagcaat 2067601 tcctcgtcta tcttcagttc tttcgccaca ttggccaaat tgttcttgat ctcaggtttc 2067661 accgtaataa acgccatcat catccccctt ttttgttact atatgacagc gtatttaaaa 2067721 aaagaaagcc tcccgctcac ttcgatgcgg gagacattgt gattatgatg cctgatcaag 2067781 catttgtttt tctttccgct ttgacgaatt gtccagcctt ttctggtcat aaaatcgcaa 2067841 caaatcccca taaatgattt catcagaaag tgatagctcc tgttttgctt tatcagcaaa 2067901 tgcttcacat tgttttgtct cttctaacgg ttttcccgtc tctttgtcat aacacgcacc 2067961 gtctgtataa acaacctgat ctgtgataaa gctcccgtcc cggagcaccg tgaagtccag 2068021 tttttcgtct gaaagcagat cgttgccgaa ttgaatttga tctttcgtat caatccctaa 2068081 aagattcatc agcgtcggcc tgatatcaat ctgcccgcct actgtttcaa tggtttgcgg 2068141 ctttttatca gtaatacccg gaatatgaat gaccagcggc actttttgga gctgtacctc 2068201 ttcaaatggg gttatttctt ttcctaaaaa ctgccccatc gcttcattat ggttttctga 2068261 tataccataa tggtcaccat ataatacaat aacagagttg tcgtataacc cgtcttcctt 2068321 cagcttttcg ataaaccgtt tcagcgcctc atcctgataa cgcactgtcg gaaaatattt 2068381 atttagcgtc tggctgtttg aatcatattc atcaatcaat tgatcctctt catcaagatc 2068441 aaacgggaag tggttcgtca gtgtaatcag cctcgagtaa aacggctgag gcagattttt 2068501 catcagctct gaggactgct caaaaaattc tttatcctta agtccccagc cgactgaatt 2068561 ttcgtcagtt acatcatacg agttaatatc aaaaaacgaa tcatatccaa atgagtcgta 2068621 cattaaatca cgattccaaa agctcttatt attagcgtgg agcaccgctg aatagtatcc 2068681 gctgtttttc aaaatttcag gagcggccat atattgattg cccgcattcg taaaaaatac 2068741 ggcacctcgt ccaagcggat acagtgaatt gtccacgata aattcagaat ccgaggtttt 2068801 cccctggcct gtttggtggt aaacattatt aaagttgtag ctctgtttta taaagtcatt 2068861 cagaaaaggc gtgatttctt ctccattcaa tttttcatta atcacgaagc tttgcgtcga 2068921 ctctaaggat acgagaatga cgttccttcc ttttgcagcg ccgaataagc gtttgttggc 2068981 atccttcgca ttagcggtta cgtagttttc aatctccgtc aggctgttgc tgtctgccaa 2069041 cgctctctgt gcggattgct ttgactgaag aacgccatcg taaatatgaa aattaaacag 2069101 gctaatgttt ttaacaagca tttctctgtc aaatgagcgt gtcaatagct gaggtctttc 2069161 cgcctcagac aagcccaggt tgaagaaata aacagaagca acgaacaaaa aataagccgc 2069221 ccgttcattt ttcgttgagg gaatgtccga ttgaaaagct ttttgccgga tgtgaagcca 2069281 tattaaaacc gcaatatcta cagctaatag gaggtctgtc ggctcaagaa gtgttccgat 2069341 gctgcttccg agatcaccca tattgctcgt ttgaaaaaga acagggattg ttaagaaatc 2069401 attgtaaaaa cggtaaaaaa ccatatttgc cagcaataca aacgtgacaa gacagctcat 2069461 cgcgataatg tagcgatttc tgtttttgcc ttttaaaaac aggctgaggc caaaaataag 2069521 caacaaaaaa ctcaatgggt tgataaacag aataaattcc tgtgttagat tgtcgatttt 2069581 aatatgaaaa ctggttttgt aaacagcata cgttttcagc cacatcaata aaatggcaat 2069641 cagcataaat gaaatcttcg aaaaaaacgt ttttcgcatt tcaacctcct atgcagcacg 2069701 ctcaaaaaaa tcagtctatt cccaacattc tcattaacac atcaaattaa atcttaacct 2069761 gagcacaaca aaaaatcaat ttcatttaca caattttaac aattttgatg tttcagccat 2069821 tcatttttag cgatccaagc gcctccgata acgccggcat catttccaag tgctgcgatt 2069881 gaaatatcag cagcttgggc tgcccgcgga aacgcgcatt tgcggaatgt tttctcgact 2069941 tttgatctca gcagttctcc ggctctcgat acgccgccgc caagaacgat tttggatgga 2070001 ttaagcgagc ttgccaaatt tccgagcacc aaaccaagat gcttggctac ataatcaacc 2070061 acctcaaggg caatttcatc attttcaccc gccgcttcaa acacatctcg cgctgacaat 2070121 tgttcggttg cttttaaacg tgtcgtcttt ttagcatttg ctattttttc ttttgcaatt 2070181 cttacaattc cggttgctga cgcaattgtt tcgatacagc ccgttttgcc gcagttgcag 2070241 ggcgctccgc cttcagggat gctgcaaata tggccgattt ctccgccggc gccatttata 2070301 ccatgtacaa tttcaccatt tgcaatgatg ccgccgccaa ctcctgtgcc aagcgtcacg 2070361 agaatgacgt cttttgcgcc atcacccgct cccttccaca tttccccgag cgcagcaata 2070421 ttcgcgtcat tttctataac agctgggatg ccggtttctg tctccagatg gtttttcaaa 2070481 gcataatttt tccaccctag atttactgtt tcataaacca ctcctgccgc catatctaca 2070541 gggcctggtg cacccattcc gatgtatttg atgatgtgct tcggtttttg cagctcatcc 2070601 agcttgctgt cgattgtttt tgcaattgtg acagtaatcg tgtcgccggt tttatctgtc 2070661 ggaacttccc acttatgctg aatttcgcca tattgattaa taaaagcgag tttaatcgtc 2070721 gttcctccca ggtcaatgcc cgcaaaccat atctcgtcca tttttatcac cttagccttt 2070781 ataaaaatct cttccgtttt ttgtttgttc caattctttt cgaaggacag ctgccgctct 2070841 ggcccactgc tccttttcaa tcatgtggtt catgtataat tcctttaatt catccagcat 2070901 aaactcaatt tcaagctctc tgtctccaaa ataaacaatg tggccaaacg tttttaacag 2070961 ctgctgcaca tcataaaatg tattcatttt cctcaccatt tcttgaactt aactatcata 2071021 agcgtattca taaggaagcg gtcagtcaag aagaaaacgc tgacaaaaaa gccagcttcc 2071081 tttccatatt ccacctctat gattctttat tgttttcaat ttgccgctgc agctccttgt 2071141 agcgctgctc cttcggcttc agtttcacag ccgtctggat ggccttttct gcttgtgcaa 2071201 gctcattttt ttccgcatac aataacgcta aattgtaata ggaagcatgg tctttaggtt 2071261 cttttttcac tgctcgttcc aaaagggaaa ccgcctgatc atattcgccg atttgaatat 2071321 cagaaacagc aagaattttc aaaagatcgg cagaggcatc tttttgcgct gcttctccgt 2071381 tcagcaattc tgttacttct tcatactttc cttcctgata cagctcgctt gcctgctgaa 2071441 tcagcgctga ctcctggtgt gaaggcgaat gcaatccgta atataaaaat ccaacagcca 2071501 aagcaatcag caaaaccgct gacaacaatc tttttccaaa ggctccggct ttaggcaacc 2071561 ccagtgctgc tgcagcgaaa aagccgccaa tcaagccgcc gatatgtcct gaattatcaa 2071621 tattcgaaac cgcaaaacca aagcccagat tgatgataat aatgacaata atattggttc 2071681 ctatagttct taaaaacatt tttcgattag acaaagcaac atacagtaat gcacctaagc 2071741 atccgaatat ggctcctgat gcccctgccg aaggatacgg gctgaacaca aaactcgcaa 2071801 tcgaacccgt aatgccagca gccagataaa tcagcaaaaa tctccccgat ccatacatcc 2071861 gctcaaccgc tgtaccaacc gaccataaag ccagcgtatt aaaagctaaa tgcgctatgc 2071921 cgatgtgaag cacgatcggt gtcagaagcc gccaccattc tccttgtgca atcaggctgt 2071981 tttcttttgc tccaaaagcc accagtgtct ccgtattagt gctgcctccg tttatttcga 2072041 gcaagaaaaa catcaggatc tgaagcgcaa taaataaata tgtaaaagtc ggttttccgt 2072101 tttgaaaaac cgccgcttca gtttttctct gttcttcttg tttcagcact agcgaaagga 2072161 agcgttctcg cgccatttgc gcgttttcaa acgaagcgtg ttcctctgaa caatcttctg 2072221 tacgaaatga tggaaaaacc gcttgaagat catctcgaag catcgttcct ctaacgatcg 2072281 ccggctcaac tgacacagtt cccttctcaa aagttttttt tgcaatctct tcccagtcat 2072341 caactggggc ttccgttgaa aaaaacacgt tcagcagctt catccttcgt ctgcccaatt 2072401 gatgtctgac tcgttctact cgttcggcct gctcttcgat gtctctaacc atttcttgac 2072461 ggaaatcaag atcgtgctta taaagacgaa ctagatcatg agaggacttg tccggcgctt 2072521 ccagccatat ttcatctgac tcaccggctt gtatgacgcc atacccgcta ttcaccaggt 2072581 gcgccgcaat tttccaatat gtatactcca gcaaaaacat gtttaccgct ccaatagttt 2072641 tttttcatta taacagctgg cgctccgaaa cgcctactga aagcaaaaaa tcccgttttt 2072701 cacgggattt tagaaagctt gctgtataaa cttattgcgg ataaatggaa ttcttaaaaa 2072761 caaatggata aaagaccgcc tgattcctgg ctggctgagt acagtattca taagacggta 2072821 gcgattttga taaaacatga cggcagaaac cgcgaaaatg gcatatatca aaagtttttt 2072881 catgatatcc ctcctgccaa tagggtttgt tattctacct tatttattct cgaataaggg 2072941 acaggaaagt tatgaaaaac aagaaataat ccgatcctct gttatcagct tatgtaccgg 2073001 gatgtcatgc ggcagacggg gtacgtgcgc aaacaactgg cactccaaaa gcaaagagac 2073061 tgtcttccct tcatattcac ttaaatagcg atcataatag ccgcctccaa agccgaccct 2073121 aaacccgtta acatcaaaac aaacacccgg aacgatcatc aagtcaattt gtgatgggtt 2073181 tacttctttt gttttttcaa ttaccggctc gagcagtccg gcgtacacgg tttcgagctg 2073241 atcatcagtc tgatatgtgc gaaattgcat tttcttcgtg tccggatggc attttgggat 2073301 gcaaacttgt ttcccttctt cccaagcctg ctcaatgaca ggacgcgtcg gtatctctaa 2073361 tcctctggaa atagtgacgg caatggtgcc ggcattttgc cactccggca gagaaaacaa 2073421 gtacttatac atacgttccg ttttttgaag aatatcttca tttgataaag cagacagtgc 2073481 ctccagcgtc ttttttctta attgtgattt catctctcat ccccctcgga atagaaaaaa 2073541 agccagaacc tttttcaaag ctctggcttt tttcttacac ctcaaacagc aaagctgtta 2073601 ttttgtttca cggtgtaacg tagatttttt atcacgtggg caatattttt taaattcaac 2073661 gcggtctgga ttgttgcgtt tgttcttttt agaaatatag ttacgctcac cacattcagt 2073721 gcaagccaaa gtaatattaa cgcgcattat tttccctcca aactaaaatc atttacttat 2073781 tcagacttat atataatacc actataatgg acggaatgct aggctgtttt tcaatgaatt 2073841 gctgaattat tgaagatacg ctcataaagc tgcaaatatg atgacataat gagtcggggg 2073901 tggtggagct tgaacacttg ttgtctgcca gcttctttta tccggcgggc tttttcccgg 2073961 tcttttaaaa aactgtccag cagatcagca gcttcctgta cgagcgtaaa atcagcgatg 2074021 attgccgttt tgtcatgaac cgcataatca caaaaaccac ctgactgaga aacgacagtc 2074081 agcacacctt gttccatgct ttcttgcgcg gcaagcccaa acggttcata agaactaggg 2074141 aaaacagcca tttcacagtg agacagtaac gttctgatat ctttcctatt tagaaacggc 2074201 agaaacatga cgcgatcctt caggttatat gccgcagcca atttctcata gcaggacaga 2074261 gacggcccct ccccagccag cactagatag aggtcaggct gacgctgctt caagatggca 2074321 aacaccttta acagctgcga taatcctttt tccggaacaa accttccata tgaaaagagg 2074381 aatcttctat tcatgcttct cgggattttc cccttctctt cctccataga tgcagggctt 2074441 gggataacgg ttattttctt atgtgccgcc ttatcaagag accgcttcat aaatgtgctt 2074501 aatacgatca atgcatcagc ggattctata aggagccgtt cggtcatgag cctgtatggg 2074561 tgtggggctt ctcggcacac cttcttcctt tcgctttcaa gaccgtggat tgtcgcagca 2074621 agcggaaggc caagccgttg tttcaaatac tgggcggcag gggcagttgt gtcatcatgg 2074681 gcatgaatca gatcaaagcg tttattgtgt gataacacat ggcgaaccat tgtaaagtta 2074741 gcatcagcta tgtaatcttc aaacttcgca tacgaaaaca gctgcccgct cggagtaaaa 2074801 accgtaatgt tgatatgagg gtttaaatag gaaatgaggc ggtttaaatg gacaccgagc 2074861 ccgcttttcg gctcatcggg atgttcgggt gaaagcatga gaatgttcac cgttcttttt 2074921 cccctctccc ataacaggtg tatgcagaaa attgcgcctc ccacctggtg tgcgcttctt 2074981 caatctgaaa actgtttata tgacgaatcc cattttcatc aagatagatg tcgtctgtac 2075041 cggcaagctt gagagagaca ttcattgaat tcacaattct gtattcagcc cgatatacag 2075101 catcaccagc cgcctgtcta atcgtccatt ctcctttatc atacgttgtg cgttttgtcc 2075161 tgacagcttc aatgtctttt cttttgatga caatgcgcaa ttcttttatc atatcctgcg 2075221 ttttttcgaa aaggaccgct tcagccagcc gcattgtttc ttctgagatt tcccagctta 2075281 cggtcaaggt gtgagcgttt tgaatgatta tgtcgaatgt gtccctaaaa aaggaaagct 2075341 tatgtcgtat attataggga aatgggtgtt tatccatgga ctcctaacat tctcctttcc 2075401 aatcgttcac ttcgtgttcc tattaaacca ttacatgaag aagaagcgaa gaaagatttc 2075461 tcgacaaaat ctcgtttttt tcgcgaattc ctttagaaac tattggtttt atggtataaa 2075521 aaagaaggat aaaaaaagaa tagaaggtga tgaaacgtgg aaattgctat tattgcgttg 2075581 tttatcgtca gtatagcgct aattgcattc tcatattctc aaagagaccc gatgaaagat 2075641 gtagaacagg agctcgaaac actgcagctt tctgcgatgc aggaaattta caagctcaaa 2075701 aagaaaatga cagtgcttga ggaagaatta ctggaaacaa accttgtcat tcgcaaatca 2075761 aagcagaacg acatcaatca aaaaatcgct aaacaaatac tttctaaata taataacggt 2075821 atgtcagctg aagcgattgc taaagctgaa catgtatcag tggaagacgt gaatacgatt 2075881 atcaaagata atgagaaggt gctcgtatga caaaacgggg cattcaggca tttgctggcg 2075941 gcatcatttt agcgacagcc gttcttgcag ctgtttttta tctgactgac gaagaccagg 2076001 ccgctgctgt aaaagataat aaaacagtaa ccgaacaaga cgtgaacaat tatcttgatt 2076061 ctaaaaaatt ggtttctgtc aaccgtgatg aatatcaaaa acttctcgat tcaaaagaga 2076121 aatccttaaa caatgacagc ggctcagaca cgaaatcaga caaagtcaaa acctacaagc 2076181 tcaccattaa agacggcatg agcacggcgg atgtatctgc tattcttgaa aaagagggca 2076241 ttatctcttc ggctcaagac tttaatgact atgtcattga tgccggctat cacaaagaaa 2076301 ttcgtgccgg cgagtttaaa gtaaaatcag acatgagttt caaaaagatc gtaaaaacgt 2076361 taacacgata aaaaaacagg ctgactcagc ctgttttttt catccaaact ttcctgaaat 2076421 gtaatcgagc gttctttggt ccttcgggtt agagaacatt ttattcgtat tgtcgcattc 2076481 aacaagctcg cccatgtaga aaaaggcggt ttgatcagaa acccttgctg cctgctgcat 2076541 gttatgcgtg acaatgacaa ttgtatattt atctttcagc tctagaatga gttcttcaat 2076601 ttttctcgtt gagattggat ctagtgcaga tgtcggttca tccatcagca aaatatcagg 2076661 attggtcgca agtgctctgg cgatgcaaag acgctgctgc tggccccctg acagcgaaag 2076721 agcggacgta tgcaatcgat ccttcacctc atcccataac gccacgtctt ttaatgactt 2076781 ttccacaatt tcctgaagct tcttcttatt tttggtgccg tggactctcg gtccgtaagc 2076841 cacattatca aaaatagatt gcggaaacgg attccctttt tggaatacca tgccgatatt 2076901 ttttcgcaaa tccacgatgt ccactttatc ctttaaaatg ttgctgccat tatagttcag 2076961 ctcacctgca agctttacat tcggcgtcat ttgaatcatt aaattcaatg tcttgataaa 2077021 ggtcgatttc ccgcatccgg atggtccgat aatcgccgta acctcatttt cataaatgct 2077081 caaattgata ttttttaaag catgatgctg cccataccat aagttcattc cattgacttg 2077141 atatacttcc tgtttcatta cagcttcggt agcaatactc attgccgccc tcctatccga 2077201 atttcccgtt aatataatcc tctgtctttt gctttttcgg actcgtgaaa atctgttcgg 2077261 tctgtccgta ttctacaagc tcgccgttta aaaagaatgc cgtccggtca gaaacccgca 2077321 gagcctgctg catattgtgc gtgacaataa taattgagta ttctcttttc aatcctgtaa 2077381 ttaattcctc tatttttgca tttgaaatcg gatcaagcgc tgaagctggt tcatcaagca 2077441 gaagaacagc cggcttcatc gcaagcgttc tcgcgatgca taaacgctgc tgctggccgc 2077501 cggataacga gagtgcggat gaatgtaaac gatccttcac ctcatcccag agcgctgctt 2077561 ttgttaaact ttcttccaca atttcatcta aaacagcttt attccgctct ccggcatatt 2077621 tcaatgcatg tgtgatattc gcatagatcg atttcggaaa tggatttggt ttttggaaaa 2077681 ccattccgat ttctcttctc aagctgacaa cgttaatatt gccgcccaat atatttaatc 2077741 cctcataaag gatttcacct tccgctcttg cagatggaat taaatcgttc attcggttaa 2077801 tatttctcaa aaaagtagat tttccgcatc ccgacggccc aattaaagca gtcaccgcat 2077861 ttttttcaat atccatgttt acatgatgaa cggcttgttt atttccgtaa taaatggaca 2077921 gatctttgac ctcaagcacg tggttctgct tcggaacaat aacagctcgc tcaggttttt 2077981 cttttaccat ttgttcagac atgtttttcg cctctttccg ttctaatttg ccgtaagctt 2078041 tttgtagatc atcgtgccaa gccatctcgc cgcgagatta aacacaagaa cagaaatcac 2078101 cagcacggca gaaccaccgt tggcaatcgc ttcagcatcc ggaatcattc cttgtgtatt 2078161 gacgttccaa atgtggaccg caagtgtttc agcgggcctg aaaatattaa gcggtgatgt 2078221 ttccgaaaac gggttccact ccgtaaaatt aagacgcggt gttgtcaggc ctgccgtaaa 2078281 taataatgcg gccgcttccc cgaacaccct tcctgacgct aaaattgctc ctgtgatgat 2078341 agaaggaatc gcacttggaa ttaaaactgt ttttacggta tgccagcgtg atacacctaa 2078401 agcgagagag gcttccttca gatctttagg gactgaacgg atcgcgtctt ctgtcacacg 2078461 caccatgaca ggaaggttaa aaacagttaa cgcaagcgct ccgcctatga tcgtataacc 2078521 ccagcctgtt aagttgacaa acatcaataa tccaaacatc ccaatgacaa tagacggaag 2078581 agatgaaagc acctctatac atgttctaat gaagtcagtt actttgttat taggcgcgta 2078641 ttcagccatg aagactccgc cgcccacacc gagcgggatt gtaatcagca ttgtaataaa 2078701 caaaatataa aaggagttaa acagctgatc tcgtatgcct cctccagctg caatggcgct 2078761 cgactttgtt gtaataaatt gaaaactgag ctgagaaaca ccgtttataa taatatagga 2078821 aaacaaacct actaaaatgg cagcgataat ggctgcacac aaaccaaaca ttccggtcgc 2078881 cagtttatct gttattttgc ggttcattac actttcctcc tagatgacaa gtagcgaata 2078941 agcaggatga acaagaatga catcaccaga agcacaagcc ccattgacca cagcgtattg 2079001 ttttcaacac ttccgtatgt ggtgtggccc atattcagcg tgatgatcgt tgtcagcgtt 2079061 cccgcagtgt caaacgggct ttccggcaat actcttgtat ttccaatgac catctgaaca 2079121 gccaaagctt caccgaacgc ccgagccatg cctaacacaa cagctgtcat caatgttgga 2079181 aaagctgcag gcacaagtac ttttctgatc gtctgccatc ttgtggcacc aagcgcgtaa 2079241 gaaccctctc gtaaactctt cggaagagaa gccattgcat cagcagaaat cgatgtgatc 2079301 gtcggcagaa tcatgacgga aaggacaatc gttcccgcca ataaactgtg ccctgttccg 2079361 ctcgatttga actgggcgat aaacggcacc aatactgtaa gacctatgaa tccataaaca 2079421 acagatggaa taccgactaa aagctcaatc accggctgca gcactttctt tccccaattc 2079481 ggggcaatct ctgtcataaa aatcgcacct gcaatgccaa gcggcgcagc gattagagca 2079541 gaaagaatcg ttactgcaaa tgagccaaaa ataaatggca gcactccgta tttcggatca 2079601 ctatctgtag gattccaatt taagctcgtt aagaattcaa ttgggcttac accatttaca 2079661 agaaaagatt gcagcccctt aacgccgagg aaaatggtaa tcgcaacaga tgccgcaatc 2079721 ataatcagtg cacaagctgt gactatcatt cttccccgaa cttcatccaa ttgccgattt 2079781 tgcctagagc tgattaagcg ctcgctcaca gacatatttt ctctattgtt tatcattgtt 2079841 ttacactcct atgaatgtgt taagaggaga aacggttgtc cccgcactcc tctttttatt 2079901 aagatcagct ttgcttcccg ttggcatcac gtgtcacttt catatcagta accggaatgt 2079961 agccttggtc agtaacaatg cttttttgaa tgtcttcact ctttagataa tcaagaaatt 2080021 ctttagctaa acctgtcgct tcaccttttg tataagaatg ttgataagcc cagatcggat 2080081 actcgccagt tgctacattt ttcgcttcag gtttaacacc gtcaatagat agagcagtta 2080141 ctttgtcatc tgttaaatat gagaatgcaa gatatccaat cgctcccgga gtatcagcaa 2080201 tgatcttttt caccgtgttg gaggaatctt cagtaatgcc ttctgcaggc tccgctccgt 2080261 caagcgcata tttcacaaat gtagcacgtg tgccggaaga atcagggcgg tttacaagtg 2080321 taatcttttg gtctttgccg ccgagctctt tccagttttt gattttgcca gtgaagattt 2080381 ttttcaattc atcttttgaa atatccttta caccagcatc agggtttaca gctgctgcca 2080441 taccaactac agcgacttga tgatcgacaa gcgcttttgc atcgatgcct tctttttctt 2080501 cagcaaaaac gtctgaattc ccgatctgaa cagctccttc agagacttga gaaagccctg 2080561 ttccagaacc gccagcttgt acctgtatat cagcatcagg gttttcttcc ataaattttt 2080621 ccgcggctgc aagtactagt ggctgcattg ccgatgaacc agaaatggtt aaagaacctg 2080681 atgccttttc ttctcctttt gcagaatcgc tattcgattt tttactttct cctgcatttc 2080741 cgcatgcagc tgcaatcatc ataaaagcag ccatcagaag cataagcacc aatttgtttt 2080801 ttttcatttc ctgaattccc cctgcgtata atgtgtaatt tgtcctacac gtatagagta 2080861 aaggttctat gtaaaaaggg tttgaaccga atgttaaggt tttgtaaatc agtgcgtttt 2080921 tttgtataaa aaaaacgccc acatcatgtg agcgtttttt tttagttatc agaagacgtt 2080981 gtgttttctg cattttcttc aattttgtct ttattctttt gctgagtacc ttctttgtcc 2081041 tgcttcgatt tcagctcaaa atatttatcc attacttccc tgccgatttc gtttgtaatt 2081101 gagtatcttt gattgtaatc aatgtaagtc caaggaacta cgacagaaat agcaatctca 2081161 ggattgtcag ctggtgcata agccacaagc gtcgtattat aagtgtctgt tcctgttttt 2081221 gatttatccg gtccgtcgta aaatgattgg gctgttcctg tttttgcagc tggtttatac 2081281 gatgctgaag ccagttgacc tgcagctgtc cctttagtgg caacccgtct aaaaccggct 2081341 tggacctctt caatatagct actcttcata tcgactttat tcaatacttc aggctgaaca 2081401 gaatcaacga ctgcgccgat cccttttttc gcatttgaat ctctgacttc ctttacaagc 2081461 tgaggcttca tgcggtagcc accatttgct atggtggaga catattgagc caattccagc 2081521 ggtgtataag tatcatactg tccaatggcg aaatcaagca agaaaccaga taatctgctt 2081581 gtacctttat atcccgtcat ttcatttggt agatcaattc ctgtttttac tcctaatcca 2081641 aattgactga aataatttct gaaggtatca aatgcagaag tatccaaagg caatgcttgg 2081701 tgaggtttat attcaccttt accaactgca attgctgttt taaacataaa aacgtttgat 2081761 gacttctcta atgcagtttg aataccaacc ggccctaagt tttgccaaga ttttttccct 2081821 cttttatcct ggccgatata caatggttca tccttaaata cagtattcaa attaatcgct 2081881 ccagtttgaa gaccggtcaa aacggttgca ccttttacag ctgatcccat agcgtaggat 2081941 gaagtcatgg ctcctaatgc ataatcatca aacttatagg ctccattttc tcgtttaatc 2082001 tgcttccctg ccattgtcag cacttcgccg tttctagggt ccatcatgac aacgaatgca 2082061 cgatccaaca attcggtact aggtcttgct ttagcagctt taagtttttt ctcaataatt 2082121 ttttccactg atttttgcaa atcaatatca attgttagta caagatcttt cccggctttg 2082181 ccttcagata ccgtttttgt tcccgtgaca ttgccttttg aatctgtgat attttcgact 2082241 tttgcttttt ggccctgcag aaggctttca tattggtatt ccagatagct ttttccgacc 2082301 ctgtcatttc ggctgtagcc aagcgacaga taatggtcga gcaagttgga cggcaatcct 2082361 tcattagagc tggaaacact tccgagcact gagcgaagaa ggtttttata aggatattca 2082421 cgttcccaat cggacgtgac atcaacacct ggcagttcgt ctaaatgttc acttaccact 2082481 gccatttcct tcgctgatac atcttcgttt ttgatatatt gaggggtcaa tgcatagccc 2082541 gaatccatct gtcttttgat agcaaggatc tgcatatctt tatccgtcaa ttcattcagc 2082601 tgcttatcag taatccgttt tagctgaagc tggtataaat cgtcatcgga tatttttttg 2082661 tcttcaacct gctgtctttc tttagagcta atgagctttt tcgcttcttt cggtctagtc 2082721 aaaatccaat aatctttttt atcccgttct gttacttttt ttgtatcgac tttgatcatg 2082781 tcagacagct tttttgcgat ctttaagcgc tgttcttgcg tggtcgattt agatctcgtg 2082841 tatgtgattg catttaaagc cttatttgtc acaatggcat taaagtttcg atcataaatt 2082901 ttcccgcgtg gtaccgctga gctgacttca ctttgttcct gcttattcgc ttggtttttg 2082961 taatcatcac cttgcacgat ctgcttgatg cccagttcca caataatcca ggtaaatata 2083021 acaaaggcag ctaaaaataa aatattcagc cggatcggaa gcgacttctt tttctcttta 2083081 tgattttgct tttttggttt atttctcctc ataacatcac cttttctatt tacagaaaga 2083141 aaagacactc aagtaagagt gccagttttc attttaaagg ttttttcgac ttttttctac 2083201 agataacccc tttttggcaa aaaaattatc tctcgccttt taaaagggtc ggttctgtta 2083261 cccgtttttg gccgtcttct tccatggttt cattttcccc ttctttctcc ttaaaacgaa 2083321 tatccttgac aaagtaataa atcaaaggat gtcctatacc caatatcgca agtgacaaag 2083381 gaattcccac atcctctttc agaagggcca caatcaggag aaagcacaaa atggaaacaa 2083441 ttctgccggc gttcaagaac atttctctaa gcacgatata ttcaattctt gcttttctgg 2083501 catgcctcgc gcgccctatc acatcatatg taagtgatac atatggcaca agcaacagag 2083561 gatagccgat ggcaataaaa acgccgtacg ttaataatgt cgaaaagctc atatggaaca 2083621 gaatcaaaaa cagcgcgcca tacaaaataa gtccgcccag caaaatcgat ttttttctcg 2083681 cctttttctt aatcagcctg gatgcaaagt agtaggcaaa gaaggaaaca gctgaattga 2083741 caagaccgaa tgtaccgaga gcaagctcgc tgtttgtctc aataaataca aacacactga 2083801 ttaaaaagac aaaaatccct tctctcaaac cctgaaaaaa atgcgcattc gtgattctcc 2083861 gccaattcat attgctatgg cgctctccaa atactttgct cagcataaaa cggccctttg 2083921 attctctccg ttttaagaaa aagctcatca cgacagccag ggcaaataaa ctgagggaga 2083981 gactgaaaat cactgtataa cccgtattat tttcaagcct tgagatcacg aatccggcta 2084041 caatcgggcc gatcattcct gcagaggaag acagaatgcc cataaacccg ttgaaaaagt 2084101 ctcgtgtatc cggctctgtt atttcaaagg tcagcacgtt aaacgctagc caataaaagc 2084161 catagccaac tccgagcacc gcgccgatta gcacgaggcg gctggccgcc gtttctccgg 2084221 ctaaaagcac acttaaataa aaggcagcta aaaaaatgac gccgaacctt aaaatgaata 2084281 ccctgtctat ttttttggct aaccgtccag ccaaataaaa ggttatcggc tgcattgtca 2084341 caatggataa attatatatc gccaaatcaa taaatttccc tgactgcttc caaagataca 2084401 cattaacaaa tgtattggac agtgcaattc ccagcgagta aagcccgcca atggtcagca 2084461 gaaagagtaa gcctttgttt acgtctacat cgcctatcac tttttttagt ttgctcatta 2084521 ctgactcccc tttactatcc cttagtctgt ctcactcaaa ccgagatatg taaaaagaag 2084581 acataaaaaa acaaggtccc ataatgagga ccttgtttgt gccattattt tgcttcgctg 2084641 tatagacgag ccacttcgtc ccagtttaca acattccaga aagctgaaat gtaatcagga 2084701 cggcggtttt gatagttaag gtagtaagca tgctcccaaa cgtcaagacc taagataggc 2084761 gttttgcctt ctgaaagcgg agaatcttgg tttggcgtgc ttgtgatttc aagtttaccg 2084821 ttgttcacaa caagccatgc ccagccagaa ccgaagcgtc cagctgctgc tgctgcgaat 2084881 tgctctttga atttgtcaaa gcttccaaat acactgttaa tctcttcagc aagcgcgcca 2084941 gtcggttcgc ctccgccgtt tggagataaa agtgtccaga ataatttgtg gttcgcgtgt 2085001 ccgccgccgt tgttgcggac tgcagtgcgg atgttttcag gaacagaatc aagatctgca 2085061 acaagctctt caactgattt gttggcaaga gcagtgtttc cttcaaccgc tttgtttaaa 2085121 tttgtcacgt atgtgttgtg gtgtttcgta tggtgaatag tcatagtttc cttgtcgata 2085181 tgcggttcta aagcatcgta cgcataaggt aattctggaa gttcgtaagc catgataatt 2085241 cctccttagt atatatgtac tgaaatgccg cttcacagcg agcctttctt cattcaatgt 2085301 aacaaaagaa tgctttgtaa tcaatgaaaa agctcacgat ttggctcatt tcagcggaca 2085361 tatttcactt taaccgataa tctgccccat taaacctgcc gccagcattt cttataggac 2085421 cgtccataaa aagtaaccga tcatcaaaag ctgtatgatg ccctttgcaa taacccctgt 2085481 taaaaaacca atgagtgagc cgaggccaat tttaaacgct gactttaagt ccttctgatg 2085541 gacgataagt tctgcgcaaa cagccccgat aaacggcccc aatatgatcc ctgcaaccgg 2085601 aatgacaaaa ggcccgatta ataaaccgat cgtgcttccc catatggcag ctttgcttcc 2085661 tccgaacctt tttactccaa gcagattcga cacgtaatct gctgcgaata atactgcggc 2085721 aaaaactgcc tcaacaagcc agaacatata agaatacgga ctgaatgaaa ataaaaatcc 2085781 gtacaataca aatccggcaa caataaatac tacgctagga ataacaggat acaccagccc 2085841 gataaaggca atgataaaaa ccgctgcaat caacagccaa tacaacatat ccatagcttc 2085901 catcctccca ttttactctg tcttcttcat gtcttccttg tattcacacg catgcaacga 2085961 tacaataagc aacatatatt agtttagcta ggaagtgaag atagtgaatg tgtttcagct 2086021 tttcattaaa agtacatact ctccccgtga tattgcaaaa acaagatttc aaggaatcgg 2086081 aaaagcgatt ctttatgtat ttttgctctc tgtcctgttt gcaatcccta ccgcttatta 2086141 tgtaagtaca gggaccgtaa aatcaatgaa cggctttaaa actgttttaa acaaagattt 2086201 ccctgatttc acaatttcaa acggcaaact tcaaacggat gagaaaaaag ccacggaatc 2086261 tcaggcaaat ggtttcgtta tcgtgttcga tccgacagac tcctatggca ctgaacaaat 2086321 tgaagcaaag caaaacgcaa tcggcatcct tcagaacaaa tttgttttgg ccattgacgg 2086381 acaagcccaa gaaatgtctt actcaatgat gccgtcagag ttacagaaaa aagatgtcat 2086441 tgcaggttta aaccaaaata aagcgatgat tgtaactgtt ctctcagctc ttatttttct 2086501 cgtaacagca gcgggaaaat ttattgaagt atcgttttta gcgcttatcg ggttaatcat 2086561 taagaattcg cagaaaaaac atttatccta tcatcagctc tggaagcttt ctgcttattc 2086621 catcacactt tcaactgtat tctttacaat catgcgggca ctagaagcaa ccgtaccaag 2086681 tgaatttttg ctgaactggt ttgtcaattt tgtcatcctg tttctcgttt taaaagagat 2086741 tccgtccaaa aaagtaatta ataaaagtta aattatattt atttttatcc tttaagtaga 2086801 gagtgtgaaa gcatttgcat taacttttta cttaagggat atttaataaa atgtatagag 2086861 cttaaacaga tacatttata aaaaaagctc tacaattact caagaacaag ctctggacaa 2086921 taatatcaga agtagtaaga tgtaacatga aagaagttct taacagcatt tgacatatgt 2086981 ttttaacaaa ataagaataa tgttaaattt taactaatag actagttaaa atcatatggc 2087041 aaaatatttt gcatcctttc acaacatatt tacataagat agttgctatt taaaaagcca 2087101 ggtaccaata gggcacctag ctttcagaat taaatcatca acaagttaga attatcttct 2087161 ttccttctat tctcattatt gaactgttat cttttttgtg ggtttatgta tacaaatgca 2087221 gctcccttag ctttcccctt atatactgat aaacctactg cccaaggtgt tcctgtcggt 2087281 tttggtaatt tactgaagta aaactttttg gttggagttc tacttgaaaa gtaccctgaa 2087341 tattgcgggc caatgtcccc accctcaact atagatacac caaagctctt ataatttagt 2087401 ttaccgcatt ttccatttgt ttcggcgtaa gcatcaatag atgttgcact cttagtatat 2087461 gtataagcat ctgtaataac tcttatttta caaccagaaa taccacttac cggttgccaa 2087521 ccactgcttg cagcctctgc tttttcttta ggtgcaacta ccaaagttaa cattagtagc 2087581 aaaattaaaa acacagaaaa ttttccttgc ttcattttgt agatcctcct ttaaactatt 2087641 acataattat cctaacagat ccattgttca ttgtaaataa tggaatacga gttttatatt 2087701 ataaaagcct ctttttgatc taattttgca ctattttcta ttttctatct gaagttaatg 2087761 tttagtcgaa gaaatcctgt caaaaaagcg cctgtataaa aaccgagcat tcgcagtctc 2087821 ttttcttttg tcatgaatcg aaatggacaa gcatactatg gtataaaatt tcgtatgcgg 2087881 gaggaaaagc gatgaagcgt ctcaccttag tatgcagcat tgtttttata ctttttattc 2087941 ttttttatga ccttaaaatt ggaaccatac ccattcagga cctccctgtc tatgaagcat 2088001 cagcaaaaac ggctgtacaa gaaccggctt ataaaacggt gaaggtaaag ccgggtgata 2088061 cggttatgtc gatagtcgga tcagcaggtt ctccggatga cattgtaaag gattttgaag 2088121 cactgaatcc aaatgtgaaa gctaacgcca ttcaagccgg aacagcgtat aaattcccgg 2088181 tctaccctta atttaacgtt aatttcttgt cagttcggcg aagacactgt tacaatgtaa 2088241 tttgtaaaat aaattcacat aaaccatact agaattgtta tatctagaag cggcaactac 2088301 aattaaggag cgattgcaag tgagtgaaat cacacatcgt acaaaaacgc gtcccgtcaa 2088361 agtgggacct ttaacaatag gcggcaacaa tgaagttgtc atccaaagca tgacaacaac 2088421 aaaaacacat gatgtagaag caacggttgc ggaaattaac cgtttggctg aagccggatg 2088481 ccaaatcgtt cgggtagcat gtccggatga acgggcggca aacgccattg cggatattaa 2088541 aaagcgcatt tccattcctc tcgttgttga catacatttc gattataaac ttgcgttgaa 2088601 agccattgaa ggcggcgcag ataaaatccg aatcaacccc ggcaatatcg gccggcgcga 2088661 aaaagttgaa gcggttgtta aagcggccaa agacaaaggc attccgatca gaatcggagt 2088721 aaacgccggt tcattggaaa aacggatttt agaaaaatac ggttatccga ctgccgatgg 2088781 aatggtagaa agcgcacttc atcacattaa aattcttgag gatcttgatt ttcacgatat 2088841 tattgtcagc atgaaggcct ctgacgtgaa ccttgcaatc gaggcttatg aaaaagcagc 2088901 gaaagcgttt gactacccgc ttcacctcgg gatcaccgag tcaggaacac tgtttgccgg 2088961 cacagtaaag agcgcagcag gactcggcgc cattttaagc aaaggcatcg ggaacaccat 2089021 gcgcatttca ctaagcgcag accctgtaga agaggtaaaa gtagcaaggg agcttctgaa 2089081 atctttcggc ttagcctcca atgctgccac gctcatctca tgcccgactt gcggccgtat 2089141 tgagattgat ctaatcagca ttgccaatga agtggaagag tatatttcta agataaaagc 2089201 gccgattaaa gttgctgttc tcggctgcgc tgtaaacgga cctggtgaag cgagagaagc 2089261 tgatatcgga atcgccggcg cacgcggtga agggctgctg ttccggaaag ggaaaattgt 2089321 ccgtaaggtt ccagaggaaa cgatggtaga agaactcaaa aaagaaattg acattcttgc 2089381 tgaggaacac tacgcaaaac ttgaagctga aaaagcaaaa ttaaaagaag aaacacaaaa 2089441 agcttgacgg gaacccgtca agcttttttg tgttagaaaa atggaataat aaatattcca 2089501 agcactaatg aaacgacacc gatacccatt gcccaggctc caaggccttg agcacctctt 2089561 cttcttgcga tatagccgac aataatacca gcagctccca ataaaacagg cagtacaaac 2089621 aatgaaatga tggacaaggc taaagcgatg taccctattc cccgtccttc attgacattg 2089681 ccgccgctgc gatcattgtc ttggtcattg ctgcggtcag cagcacgata aggctctgcg 2089741 atttcagcag ctgtttcctc aaaaaaaccg tcattgtcgc gggtaatatt tgtcccttca 2089801 gatccatgat caacatagta actgttgtta tcacgctttt cgtaatcgtt tgccaccttc 2089861 aattccccct tctgttttat taaaggagct tttatagttt gatccatttt gcctgattca 2089921 tgtttgctaa acttttctgt taatgtcaat tgtttatgtt acacttgaag ggatgaaact 2089981 gaaggagtgt gggcatgtta cgcttaggaa tagatattga cggcacaatc acggctcagg 2090041 atacattcgt cccttatttg aaccgttcgt ttaatctttc catttcatta aacgatatga 2090101 cggattatga tttaacaaag ctgttaaaca ttacccagga agaattttgg gattggatga 2090161 atcaaaatga agcgatcata tataaggaag cattgcttgc acagcatgcg aaacagtctc 2090221 tcgatcttct caaagaggag cacaagctta tttatattac agcgagacgg actcatttaa 2090281 ctgatattac ttatgaatgg tttgacagac aaaacattca ttatgaccac atcgaacttg 2090341 ttgggggtca tcacaaagtt gaagcggtca agaatcataa catcgacctg ttttttgagg 2090401 atcatcacgg gaacgccatg atgattgcga aagaagccgg gataccggtg attttgttca 2090461 attcccctta taatcagctt ccgattgatt caaacatcat cagagtaaac aactggctag 2090521 aagccgttca atggatgaac aacaacaagc atcacttaat acgcgtcaat aactgaaaaa 2090581 ggagcccaaa ccgggcccct ttttcatata tacgcatttt acgcagtagt gttttcttgg 2090641 ttttccgctg tacaatcagg gcatgtgcca taaatctcaa atttatgccc gctgacctga 2090701 tagccatcca aatcatcaca aagcttgtcc atcggacatg attcaatttc ctttgttttg 2090761 ccgcaggcaa gacaaataaa atgatggtgg tgatgggtga atgaacactt aaatcggaag 2090821 agcttttcac cggacagctc agttgtttcc aaaatcccaa gttcttcata taaagaaaga 2090881 tttctgtaga ttgtatcaaa gcttaagcct ggataatcat cattcagtgc agacagtacg 2090941 tttttagcgg taagatatct gtctgaatca gcaaaaagct gcagcatatc ctcccgtttg 2091001 tttgtatatt tatatccgtt ttcttttaat aggttcagcg cttcttggac gttcatgaag 2091061 ggtccccctt ttcgctttgc ttaagaacgt atcacatgta tgaaaaagaa aatggcagct 2091121 gtctgtccag caagccattt tctttactgc agataaaatt atacccataa aatgaataaa 2091181 agtaaatgaa agcctagtgg attgcgtttt tgaattttcc gcctctcgtt tcatgagtat 2091241 tcataattgt tatgaatgca ttttgatcaa cttcaaacac gatcgatttg agctttgtca 2091301 cttccagcct tgtgacaacc gcgtaaatta cgtctttttc ttcgtccgta tacccgcctt 2091361 tccccttcag cttcgttgtg ccccgaccga gacggtgcaa aatcgcgtcg gaaatctcat 2091421 catactgctc agacacaata atgacagctt ttgtttcatc aagcccttgg atcacggcat 2091481 caatcgtttt catcgcaata taataagtca tgaatgagta catcgcttgc tcaggaccga 2091541 acacaaaaac tgcccaaatg aaaatgaaca cattgatgaa cataacgaac tcacctacag 2091601 aaaacgggag ttttttggtc agcaaaatac cgagaatttc tgtaccatcc attgaacctc 2091661 catttcgaat aacaagcccg acgccaaagc cgagtaaaag acctccgaac acagtagcca 2091721 aaataggctg ggttgtaatg gcttctacat ggtgaagtga ggattcaata acggcaagcc 2091781 cgacaatccc tataaacgta gagactagaa aggtcttacc gatatattta tatccgaaga 2091841 tcataaaagg aatatttaat atgacaacga aaaaagcgaa attcagaaag gggtttgaca 2091901 taaagaggtg gtctaaaata agagatacac cgataatccc gccatcaata aaatcattgg 2091961 ggattaaaaa taattcaata cttacagccg cagatgcagc tcctaccaga atcataaaga 2092021 ccctgaaaat aaaatgggta aatgtttctt tcttatgttg ttttgttggg gtcataaaat 2092081 ctcctttcct gcaataacta ttttaaatac attataaatc tattttacca ttaaacactg 2092141 acacatttta ctgatttgcc catacattaa gtctggaggt ggaatgaccg atgattttat 2092201 ttcaaagaat tattttgcag cggcttaatc aggctactgc tgatgatttg ctgaagtact 2092261 caaaacaata cggaatcagc ttaacaagat cgcaggccgt tgaagtagcg aacctgttat 2092321 acgggaaaaa tgtaaacatc tttaatgaga gtgaacgaat gcggctgctg aaacaagtag 2092381 agacgattac atcgaaagaa acagctcaaa cagttaatga actattcaaa caatttacaa 2092441 gctaaaaaat gggggtgtta tcccccattt tttattgctg taaaatcttt tcaagcaatg 2092501 tatcatcaaa ttgtttttct ttcagcattt caatctcaaa acggtatggc ggttttttgt 2092561 tctttttatc ttcaccgacg tatggtgttt caagaatttt tggaatgtct tttaactgct 2092621 catggtgaac aacatattgc agtgcgtcaa aacctatttc accaaagcca atattttcat 2092681 ggcggtcttt tctcgcacct ttgacatttt tgctgtcatt gatatgaagc actttaatac 2092741 ggtcaatgcc aatgatttta tcgaactcat ttagcactcc gtcaaagtct tcgacaatgt 2092801 tatacccggc atcatgtgta tggcacgtgt caaagcacac tgacagctgc tcattgtgtg 2092861 taacgccttc gataatctgc gcaagctcct caaagcttct gccgcattct gatccttttc 2092921 cagccattgt ttctaatgca atctggacat tttgattcgg atcaatcact tcatttaagc 2092981 cttcaataat ttttttgatg ccggcttcag ctcctgcccc tacgtgagcg ccaggatgaa 2093041 ggacaatttg cttcgctccg atggccgctg tccgttcaat ttctgaacga agaaaatcaa 2093101 cacccagctc aaaagtggac ggatttgtcg tgttgccaat attaataata taaggcgcgt 2093161 gtacgataat ctcgtcaatg ccgttttctt gcatatgtgc ccggcctgct tctatattta 2093221 agtcttcaat tttctttcgg cgcgtatttt gcggtgcgcc tgtatagatc ataaacgtat 2093281 tcgccccata agagactgct tcctggcttg cagccagaag catatgtttt ccgctcatag 2093341 agacgtgtga gcctattctc agcaacaggt tcccctactt tcttttctta gattggtttc 2093401 ttctctgttt tttcttgatt ttctccatct catagctcat tttcttttta tacccaggct 2093461 taaccttctt cggctttttc acgagacgat gagcaatttc atccgcttca ttcggcgttt 2093521 ttttacgttt tttgcggcgc tgacggtcat cgcctttttt ccattcgccc ttttcaagct 2093581 ctaagtactc aaattcgatg cccatttttt caagtcttac taatgcatcc tcatcagtaa 2093641 gctcataaat ggtcatcgct tgtcctgatg agccggcacg agccgttctg cccacacggt 2093701 gaacatagaa atcgagatca tccggcagct catagttgat aacatggctg acacctttaa 2093761 tatcaatacc tcttgcggca aggtcagttg caatgatata tgtgaattcc aaatcattga 2093821 tctgcttcat gacttttttc cgctcacgtg gtgttaatcc gccgtgcagc aagccgattt 2093881 tcatgccttt gccagtcaga tactgggcaa tatggtcagc cgtatttttc gtgttggcaa 2093941 acacaatccc caggtatgga ttcagatgcg acatgatgtc aaaaaggagc ttgtccttgt 2094001 cacgatgttt cgaaggaatg aggatatgct cgattttcgc agcagtcacc tgttttggct 2094061 ccacatgggc gtatttcgga ttttccatgt atttcttcaa gaatggtttc agcttttccg 2094121 gtatggtcgc tgagaacaca agcatttgca gatcctcagg catgcgggaa ccgatgtaat 2094181 ctacatctgc aaggaatccc atgtccagca ttaaatccgc ttcatcaata acaagagatt 2094241 ccgctttatg aacacttaac gcctgttctt tgattaagtc agcaatccgt ccaggtgtac 2094301 cgacaacaag atgcggctgt attttcaatt tatcaattga tttttgttta tcagtgcctc 2094361 cgataaaaca tttcgagcga atctgacttc cttcttcacc ctgcgtgatt ttaagcgctt 2094421 cctgataaat ctggttggca agctctcttg tcggagccgt aatgactacc tgaacgacat 2094481 ccttagcagg atcgattttg tttaataaag gcagtaaata agcgtgagtc tttccagtac 2094541 ccgtctgaga ctggccgatg acgctttctt tttttaacac tgcaggaatc agccttttct 2094601 ggatatcagt cggttcgtaa aaaccaaggc gatgtactgc atctataata aatggtttca 2094661 attcataaag ttcaaatttc gtttctttca tttttcccag ctccttaaag cggcacatta 2094721 tgtgtccatc atcacattat acccgatttt gcttaaaaac accacgtttg caaggcgttt 2094781 gttttattca gttatgtaaa gcaaataccg cagcccatgc atattctaat agcagagaga 2094841 gctgaaagga ggtacaagta tgttttcacc gcagcagcca atgagaaatt acccacagcc 2094901 cggaccgccc cgccccatgc caaatcagcg aatgatgggc agaagaccgc ctaatatgcg 2094961 aggaccttca tttggagcac agcagcaagg ttttcagcaa gccggacaat ttcttcctca 2095021 ggcaaatgcc ggagcgagaa atggtgcagg tgcaggcgga ggcttaaaag gaatgctgtc 2095081 aaggttcctc cccggcggag gaggcgctgg cagcgccggg gttcccggaa ttccaggagc 2095141 aggtgcagca gcgagcggag gtgctggcct gcaaggcatt caaaatattg ccaatcctgc 2095201 atcattatcc agtatgcttg gaaatgtgca aaaagtactc ggcatggcgc agcaagtcac 2095261 ccctatgatc cagcagtacg gcccattagt ccgcaatctg ccagcaatga tgaagctgta 2095321 cagccaatta agtaaaagtg atgatactga gacagaggcc aatgaggaaa gtgaaaaaca 2095381 atccgtttca gaagaatcat cagaaaaaga aaaagagact gaaacaaaaa cctcagatgg 2095441 gaacaaaaaa tcaaaaccaa aaagttcttc tctcccaaag aaatctaaaa caactgacaa 2095501 taaagaacaa gaattaaaaa catctgcccc gaagaaaaag gaagctgcct ctcctgctcc 2095561 gaaaagaaca tcaggcagtt caaaaccgag attatatatt taacattctt tgatatctta 2095621 agtgagattg gctataatga gatcagaaga atgcaagaat agagccgttt gattacggct 2095681 ttttatattg cctttactca cttcagtatt ggaggacaac cgaaaatgga cgtaattaaa 2095741 atttcaccgc gcggctattg ctatggtgtt gttgatgcta tggtcattgc caaaaatgcg 2095801 tcgctagata aaagcttgcc aagacccatc tatatactcg ggatgattgt tcataataaa 2095861 cacgtcactg atgcgtttga agaggaaggg atttttacat tggacggctc taaccgtctg 2095921 gacatcttaa agcaggttga caaaggaact gtcattttca ctgcgcacgg tgtttctccc 2095981 gaagtcagaa gaatcgcaga agaaaaaggg ttagtcgcaa ttgatgctac atgtccggat 2096041 gtgacaaaaa ctcataatct aatcttagag atgaaagaaa aaggatatca cgtgatctat 2096101 atcggcaaaa aagggcatcc agagcctgag ggagccgttg gcgtagcgcc ggagatcgtt 2096161 cacttagttg aaacagaaga agatgtaaag aaccttgata tccaatctga gaagttaatc 2096221 gtgacgaatc aaacaacaat gtctcaatgg gatgttcacg acattatgga gcttgtcaaa 2096281 gaaaaatatc ctcatgtcga atatcaccaa gagatttgcc tcgctactca agtgcggcag 2096341 gaagctgtat cagagcaggc aaaaaaagcg gacttaacaa tcgttgtcgg agacccgaaa 2096401 agcaacaatt caaataggct tgctcaagtg tcagaggaaa tagccgggac aaaagcatac 2096461 cggatcggcg acttaagcga attgaagctc gaatggctga aaggcgttaa taccgttgca 2096521 gttacagcgg gagcttcaac accgacgccg atcacaaaag aagtcattcg ctttttagag 2096581 cagtttgatc acgaagatcc atcaacttgg acaactgaac ataatatacc gctcaaaaaa 2096641 atacttccaa aagtaaaagc aaaaaactga ggctgtaaaa gcctcagttt ttttatagaa 2096701 atgtaaatgg atttgtatct gtttcagaaa caaagatatt cacgccaaac tttttatcat 2096761 tacacattga tgtaagtttt ctcgtgacgc cttctttcat gattttttcc gcgtaatggc 2096821 ccggatcaac cacatttagg ccaagcatca tcgcatcatg ggccacatgg aagtataaat 2096881 ctcctgtgac gtaaacatcg gctccctttc gttttgcatg atgaatatac ttgtttccat 2096941 ctccgccaag aacagctact tttttcacca tgctgtcagc atccccaacc attctgacac 2097001 cattgacgtc aagcttgtct ttcacaaata aagcgaattc cttgagcgtc atctcatttt 2097061 taagggttcc gacacggccg agcccttttt cggcgggagt ctgttcgaca ggatagatat 2097121 cgtaagcgac ttcttcatat ggatggcttt ttatcattgc attgataaca gccttttcga 2097181 cgcttttagg aaatacagtc tcaagcctta cttcatgaac aagctcaagc tctcccactt 2097241 caccgataaa aggcttagct ccgtccaatg gcttaaagct gccgattcct tcagatgaaa 2097301 acgcgcaatg gctgtattca ccgatatggc cggcccccgc atttccgagc gcggctctga 2097361 cctgctcttc atattccttc ggcacgtaaa ctgccagctt tttcagagga tccgtataag 2097421 taggtgccag cacttccgtc tcactcagct ctaatgcttc agcaagcaaa tcattcacac 2097481 cgccgtccgc aacgtctaaa tttgtatgag ctgcataaac agcaatatca tgcttcaaac 2097541 acttttcaat taaccttccg gcaggctgat ctgttgaaat atgctttagc gaccggaaaa 2097601 ttggtggatg gtgtgcaata atcaagtcaa cctctttttc aatcgcttca tcgataacgc 2097661 tctctaacac atcaagtgta accatcacat ttttaattgg tttgtttaag gtgccgattt 2097721 gcaggccgat tttatctcct tcaaccgcat aggctttcgg ggaaaattgt tcaaacagct 2097781 ggatgatctg ctgcccattt acacttttag ccatgatcga ttacctcctt taacagctcc 2097841 attcgatcgg cgagctcctt taatttttgt ttgttttgct ctgtatccgc cgcttggctg 2097901 atctgttcat aaatgctttg agtgtgctga agctcttgtg tccacttttt caaaaagaca 2097961 gcattttttt cttttgccaa gaaagggcca acgagcatcc cggctgataa agaaataccg 2098021 tcataagccg catccctgtc tcccgcttct gccaccagca cctcatagca ctttccgtcc 2098081 tcttcaagga ttacctcatc tatcagcgca tatctttctt tataaagcca ctccctgata 2098141 tgaacagcat gaatattcgg ctgtaaaatg agccgttcct tccccgttaa tttgtctttg 2098201 cccgcttcta aaatgtgagc gatcaaagcc ccgcccattc cggcaatcgt aatggcatca 2098261 gcttcacctt ttttaatcac ttccagtccg tctccctgcc ttacagaaat gtgcgagttt 2098321 aagcctgatt tttcaacctg ccgctttgca gacaaaaatg ggccgtctgt tatttctccg 2098381 gcaatcgccc cgctggcttt atgattcagc accgcataac aaggaaggta ggcgtggtca 2098441 gagccgatat cggccatcac cgctccattc ggtatgtact ccgctactgt ttgcaatcgt 2098501 ttagataatt ttaattcgtt cacttgtcat cacaactttt ctcaatcatt ttttccttta 2098561 ctatcatata aaaaatcagc ccggaatcca agctgaagca aatgattttg aaattatttc 2098621 ttttgatgcg ggtctgcacg cagcagtcaa aaataaaagg ctgtcgagaa catctcggcg 2098681 gcctgtgaat gtataaagag aaaaatagtt cttttattta atttttgaca cccactctgc 2098741 catatcatcc agcttatcgg ccggaacaag accggaaggc attccattac cgcctttttc 2098801 gatctttgtt ttaatttcag cgacatcttt cttatcccct acacctttta agctaggacc 2098861 cgaaacacct tcataatttt caccgtggca tgcgatgcag tttgccttgt aaatttcttc 2098921 tggtgaagcg tttgcatctt tcttttcagc agatttgctt tctcctccgc tcgcaatctc 2098981 ccgagagtca tcaagtcctt ttactgataa aaagaaagtt agaccaattc ctaaaacagc 2099041 gatcagcaaa aatggaataa gcgggttcca tttcatttcc cttccccctt tttgatcctt 2099101 ccccctatgt aaacacttct aattctaact tatttttaca aaaagtaaat ggattgctat 2099161 acaaaagttt tttattcaca ctttatacaa aattgaatag aaacatgcct aaatctctaa 2099221 tatccttttt attctattgt ataatgtatt gtatacgctt acaatagaaa atatggaatt 2099281 agattttgaa atttttcacc acaatgttca tttgcaaatg acatcatttt tcagtaaaat 2099341 aaaggcatat tatccatata tctttttaaa aaaagaagaa cggatcttca agacccgttc 2099401 catcttattc aaggaaatct ttcaaacgtt tacttctgct aggatgtctt agtttccgca 2099461 acgctttggc ttcgatttgt cgaatacgct ctctcgttac tccaaatact ttgccgacct 2099521 cttctaatgt tcttgtacgg ccgtcatcaa gaccgaatcg aagacgcaat acattttctt 2099581 cacgatcagt taacgtatca agcacatctt ccagctgctc tttcaatagc tcgtatgcgg 2099641 cgtggtcaga aggtgaagtt gcttcttggt cttcaatgaa atcaccaagg tgcgagtcat 2099701 cctcttcacc gatcggtgtt tccagagata ccggctcttg agcaatcttt aagatttcgc 2099761 gtactttttc aggcgttaaa tccatatctt ccgcaatttc ttcaggtgtt ggttctctgc 2099821 ctaagtcttg cagtaattga cgctgcacac ggattaattt attaatggtt tcaaccatat 2099881 gaacgggaat ccggatcgtt ctcgcctgat cggcaatggc gcgtgtaatc gcctgtctga 2099941 tccaccacgt agcatacgta ctgaatttat aacctttgcg ataatcaaat ttttcaacgg 2100001 ctttcatcag gcccatgttt ccttcctgga tcagatcaag gaacagcata ccgcgtccga 2100061 cataccgttt tgcgatactg acaacaagcc gcaggttcgc ttcagccaat ctgcgtttag 2100121 attcttcgtc accttcttca atcttttgag cgtaggcgat ttcttctttt gcagaaagaa 2100181 ggttaacccg accgatttcc tttaaataca tacgaactgg gtcattgatt ttaacgccag 2100241 gcggtacact taggtcatta aggtcaaatt cttcttcggc tttggcaagc tgctgaatat 2100301 taggatcttc tgtttcttca ttctcactaa ttaattcaac accttgttca cctaaaaatt 2100361 cataatactc atccatttgg tctgattcaa tttcaaagct ggacatacgc tcagcaattt 2100421 cttcatatgt caaaacgcca cgttttttac cagactctgt taattgctct tttacttggt 2100481 cgaatgttaa ttctgtctcg tgggtttgtt tatcagccat tatggatccc tccttccaaa 2100541 gcttgcaacg aattctataa gcggtatgat tcttattcgg tccattcagg cgttttctat 2100601 gtgaactgcc tttaacaatg tgcgaataat gaaatgacaa ttcatgatga ggttaagcga 2100661 tctatttgct cctccgcaag gaatcattgc caataaatgc tcctcatcag ttctccagtt 2100721 attttaaaga tcggttcaat gtaacgattt cttgagccaa agaagcagct cttaaaaaat 2100781 ctttttgcct ttctgcttcg gctctttccg cctctttttc ttttatcatt gaccaatttc 2100841 tttgattcaa cacttttttt acataatctg ataactcggc ttcgctaagc tcttgattaa 2100901 cctgaagcat taatatatcg gacaagagct ggcttatatg atcatccgtc accctggcca 2100961 tcagatgctg aggcgtcagc tcggctccct cttcataaaa agcataaaga taagcggcta 2101021 atgcccggtg ctcatcaata ttaaattgaa accctacccg gtcaatcact tttttgatga 2101081 cgctccgatc tcgaagcatg tgagcgagta acagcctttc tgcattttca tacgccggac 2101141 gcaaacgttt ttgccttgct tttgtcgtca gatgcgctcg ccgcgtttta gtttcaccgc 2101201 tattgtcagc aggtttgttt tgcttgctga aaacagacag ctgctcagtt aaagactcct 2101261 gtgaaagcga aaactctgaa gcaagctgct ttacatagac ttcctgctct agagaccctg 2101321 aaagcgtgct gatttctttc agtacgtctt taatgtaagc taggcggtcg ccttcatcgg 2101381 acaggttctt tccttttcgg aaatattgca ttttgaacgc cattacggtg acacttgcgt 2101441 caataatgtc gtttttaaat ttttccccgc cgaatttttt gatgtaatca tcagggtcca 2101501 atccgtcagg aatcattgca actctgactt tgcagccttt tttttgcaga agctccgaag 2101561 cttttaaggt ggcttcataa ccggctttat cagagtcata gcaaagaatg atttcttcga 2101621 cgtttcttct caggatcttg acatgatcat ctgtaagaga cgttcccatc gtggctatgc 2101681 tttcctttac atccgagctt acggccgata tgacatcagc aaacccttca aataagactg 2101741 ctctttcctg ctttctgata tgaaggcggg ccttataaaa attgtaaagc agtttgcttt 2101801 tatgaaagag cggggtttca ggactgttca tatacttagg ctgctggctg ccaagagccc 2101861 tgcctgagaa agcaacaaca gccccgtgat gatcatggat cggaaacatg acacggtttc 2101921 tgaagcggtc gaaatatccg cttccgtctt cgcgtctgat caggagaccc gctttttcca 2101981 tttgcgcctc actaaatccc ctctttacaa ggaatttcgt gataaagtcc caagaatcaa 2102041 gagcatagcc aatctgaaat tcattaatca gctctttcgt aaagccccta gaaagcagat 2102101 aatccagtgc ctcttgacct tcttttgtat ttattaacaa atgatggtaa aatttcttca 2102161 ggagctcatg tgcctcagcc attttttgtt ctccagaaga ctctggccgg gctccggaat 2102221 ggactgttat atcatctgga aaatcaattt ggtatttgtc agcaaggtga gaaaccgact 2102281 cggcaaaaga atagccttcc atctgcctta aaaaagagaa aacattgccg cccgctccgc 2102341 agccaaagca atgaaaaatc tgtttgtcgg gcgatacgga aaacgaaggt gtgctttctc 2102401 catgaaaagg acagagtcca aagtagtttc ggccttgctt ctttaattga acataatcac 2102461 ctatgacttc aacgatatct gccgactttt gcacctgatc cacaatttca tctggtatcc 2102521 gatttcccat cttataacac tccgtcgtac attattcgat gctttagtgc aaaatccctt 2102581 catcgttcga caggattttt tgcagcagtg taataaatcg ttctcgatct tctttattca 2102641 attttttagg ccctttggca tatacgcctt ttcttctttg tttgccggaa aaatgacggc 2102701 cctctagggc aaaatcaatc gtgtcttcct tgtaaagacg acctctttcc gacataacag 2102761 agacatttct gttcaacagc agagatgcta atccgatgtc ctgcgtcaca acaatatctc 2102821 ccggtttcac gtgatttgcg atatataaat cagcagcttc tttatgagga tcaacatact 2102881 tccatttttc ttcattgctt ctggaaagct gataatgttc aaatgaagcg acaaaaagaa 2102941 cttgaacttc atactcggat gctgtttgta aaatttcatc ttttaccgga caagcatcag 2103001 catcgacaaa aatcgtcttt tcttgttcat taagaagagt aattctccat ccctccatta 2103061 aactcctgca taaaagcaag caaaatcgca catcctttat tattgtggat gtatatgaat 2103121 ttgtcgaaaa atttccggga gaaattcttg acatcttacc cataatagtt tattcgtatc 2103181 acacgatcct taaacctaaa attaatcatt ttatcacaat tttttattat aatacaaact 2103241 tcacaaagat gctattgttt ttcattattc ccttttggca cagccaaaaa cccaggatag 2103301 agcgtcctga gttatatgtt ttttgttttg agatgatgga taatatttgc tgtttcctca 2103361 accgctttat ttgaaacatc aacaacctgg cagccgatcc gatccacaat cttttcgaaa 2103421 tactcgagtt cctctttgat tctgttgata tttgcataaa tcgctttatc attaagcccg 2103481 agtgatttta aacgttcttt tctgatatga ttcagtttat cagggctaat ctttaaaccg 2103541 atgcattttt tcggatcaac gttaaagagt tcttccggcg gatcaacctc cggtacaatc 2103601 ggaacattgg caaccttcag gcgtttgtgt gcgagatatt gagacagcgg tgttttagac 2103661 gttcttgaca cgccgatcaa aacgatatca gcttttaaaa tccctcttgg atcacgtcca 2103721 tcatcgtatt taactgcaaa ctcgatggcc tccacttttt tgaaataatc ttcatcaagc 2103781 tggcgcaccc gccccggttc gtatttcgct gttaaaccgt aggctgtttc cattttatca 2103841 atcaacgggc cgataatatc ataatataaa acatttgctt tttccgcttc ggctatcaaa 2103901 tattctctga tttccggcac cacgagtgta aaacagataa tgccgccgtc tgcctttgca 2103961 agtgaaatca cttcattgat agtgcctata tcttcaacat aaggaattct tcttacatga 2104021 gtatcatccg ccgatccgtt aaattggctg agtgctgctt ttactaccaa ttcagccgtt 2104081 tcaccgacgg aatccgatac aacatagatg atgcggttat tcatattatc cccccgttag 2104141 tttgcaatct tataggattt cattttcaga taaactgaca agtattttgg tcatatttgt 2104201 ttttgtcact ctgccgatca cttcaaagcc tttatcggtg tctttgatga caggcagtgc 2104261 atcaatttgt ttttctatta agtgctttgc aatgtccatc acataatcct cgcgtctgca 2104321 caccgtaatg ttcggcatcc ttgtcatgat gatgtgaaca gggaccgatg taagctcctg 2104381 ctggccaatg ctcgctctga gcaagtcttt tcgtgaaagc accccgacta aaacagcatc 2104441 gcggtccacc acaaacagag tacctacatc ttctaaaaac atggtgcaaa tcgcatcgta 2104501 cacagaaacg ttttcgtgaa tcactacggg gatagattga aagtctttca cctgaagctt 2104561 tttgagttta tccgccaaaa gctgtgtgcc ggtttttccc gtatagaaat aaccgactct 2104621 cgggcgcgcc tcgaggaatc ctgacatggt gagtatggct aaatccgggc gcaatgtcgc 2104681 cctggttagg ttcagctttt ctgcaatatg ctcccctgta atcggcccgt tttcttttac 2104741 aatctgcaaa atatgttctt gccgtttatt tagttcgatc gtactcacca ccttttcact 2104801 tcatagctat gtaaagaaat aacaatccat attataacgt aaatatcttg taatcaaaca 2104861 aaaaacttat aaatggggaa aagacgatta ccgatcacac agcaaccgcc ttttctctct 2104921 ttattttaca ataagggcat tcatattcgc aaaggacttg atctcatccg ccaagcttac 2104981 catttgcgct aaacgatttg cctttaatga ctcattatcc gctataacca ttgtatgatc 2105041 gaagtaagca tcgatcggtt cttttaaggc tgcaagtgaa gcaagcgccg cctcataatc 2105101 ttttttgctg aagttttcct gcagattttg cttcgctgtt tggtaggcat caaacagttt 2105161 tgcttcgtat tcattttcaa acagatcagg ctgaatgtct ccgcggactc cttttttgct 2105221 gatagagatc actcggccta acgcttcggc tgtttcctta aagccaggtg caccaagctt 2105281 ttgctccagt acttgtgctt tatgcagcgc agagtacggc tcaagctcag agctttccag 2105341 cacggcgtca atgacatcat gtctgatttg ttcagcattc aagacatatt tcaagcgctg 2105401 agtgaagaaa tccagcagtt cattttcttt atcggtttga acgaaagtaa gcagctcttc 2105461 aaatgaaatt ccccagttgc ggtcaagaag aatcgcaaca ataccgcttg cttggcggcg 2105521 cagtccgtaa gggtcctggg aaccggtcgg aattacgccg atagagaaga atgaagcgat 2105581 tgtgtcaagc ttatccgcca ttgctacaac agctccggtg aaagtagaag gcgtttctcc 2105641 gcccgctgat ctaggcatat aatgttcatt aactgccgca gccacagctt catcttcgcc 2105701 aagcattctc gcatactttt cgcccataat tccttgaagt tcagggaatt catatatcat 2105761 atgcgtcaca aggtcgaatt tagaaatttc agcagcccgc ttcacatgtt ttaatgtatc 2105821 ttcatcagcc tgaagacgaa cggcaagttt ctctgcgatt gatgtgactc tcctaacctt 2105881 atcagcaaga gaaccaagct cttcatggaa aacgatattt tcaagcttct tcacatttgc 2105941 atcaatgttt agtttctgat cttctttgta gaagaatgaa gcatcagata aacgtgcgcg 2106001 cagcactttt tcattgcctc gggccacatt ttcaatcgcg tggctgttgc cgtttcggac 2106061 tgtgataaag tgaggcagca ggtcaccgtt tttgtctttg acagggaagt agcgctgatg 2106121 ctctttcatt gtcgtgacaa gcacttcttc aggaattgac agaaactcgg attcaaatga 2106181 accgtaaaga gctgtcgggt attctactaa atgattcact tcatcaagaa ggtcttcgtc 2106241 aactggaatg ctccaattgt tttcagcagc cattgtttcc agctgagatt gaatcatttg 2106301 ctttcggacg ctaggatcag caataacatg ctgtcctttg agctgctctt cataagctga 2106361 aggtgattca attgacactt catgtccgag gaaacggtgt ccctgtgttg tccgtccaga 2106421 ctcaacgttt gtgatcgaaa atggaatgac atcctgtcca aataatgcga caatccattt 2106481 gatcggtcgg atataacgca aatcttcatt tccccagcgc atgtttttcg ggaaatgcaa 2106541 gcttgtaatt aaaccgctca attctggcag aagcgacttc gtttcttggc cggcttggaa 2106601 tttttgcacg aatacatact ctatgccttt tacttctttg atgtacaggt cttccacatt 2106661 tgcgccttgg ccttttgaaa agccgattgc cgcttttgtc cagttcccgt ccgcatcaag 2106721 ggcaattttt ttcgcaggcc cttttgcttc ttcttttata tcatcctgct tttctgcgac 2106781 atccttaacg aacacagcaa gacgtctcgg tgtattgaag agtttcactt caccgtgagt 2106841 aatatttttt tctttaagcc agcctgtcag cttgtcgcca agctgaacca tgctttcatt 2106901 caaaaagcgc gccggcattt cctctaatcc gatctctaaa agtaaatcct gtttactcat 2106961 gagaagaacc ctccccttta agcattggga accctagttt ttctcgttcc tcatagtagg 2107021 tttttgctac ttttctagct aaattccgca ctcttgcgat atagcccgtc cgctcggtaa 2107081 cagagatcgc acctttggca tcaagcaggt tgaaagtgtg cgagcatttc agcacatagt 2107141 catatgctgg atgaacaagt ccgttgtcca tttgcttgat cgcttctttt tcatatgtgc 2107201 tgaacaattg gaacagcata tcgacgtctg atgtttcaaa cgtataaaca gaatgctcat 2107261 attcagccat catgaataaa tcttttactg taaaccctga cgtccattcc aagtcaaaca 2107321 cgttttcttt atcctggata taagacgcga gacgctcaat tccatacgta atctctacag 2107381 aaacgggttt acactctaat cccccgacct gctggaaata cgtaaattgt gttatttcca 2107441 ttccgtcaag ccaaacttcc cagcctagac ccgcgcagcc taaagacgga ttctcccagt 2107501 tgtcttcaac aaagcgaata tcgtgctcaa gcggatcaat tccaagagca cgcaaggaat 2107561 ccaaatacag ctcttgaatg ttatcaggtg acggtttaat aatgacctgg aactgatgat 2107621 gctgatacag tctgttcggg ttctccccgt agcggccgtc tgccggacgt ctggaaggct 2107681 ctacataagc cactttccac ggctcaggac cgatactgcg caaaaatgta tacgggctca 2107741 tcgtgccggc tcctttttct acatcgtaag cctgcataag cacacagccc tgactggacc 2107801 aatgcttttg caaggttaga atcatgtctt gaatattcat ttcaagcacc tccacttttc 2107861 tttcataagt tgactgcggc agcaaccaaa aaactcccgt ctctatgctt gccagccgca 2107921 aacataggga cgagagttct cccgcggttc caccctagtt gctgagaaca aaatcccagc 2107981 ctctttttta aaattgctca agaatgcctt tcgttgcgtg ctcatcctta gcttacaccg 2108041 ccctaaggtc gctttcatga ggtaaacgca agtacttctt tctctcactg caacatattt 2108101 tataataaat gatcatataa aaagatggac caaatgtcaa cttttgtttt cacccataag 2108161 atgtttcatg ctttccattt gatctaaaaa gcgctttgat tttaaataca atcccgaata 2108221 ttcttcgtaa tataaatcaa tcacttgctt taattcagct tttgtttcct cttttaagga 2108281 cacattgccg agtctcgaca gatcaaaata gtaaaagagc cttaacagcc ttgccgtttg 2108341 cggtttaatc ggtatcctgt aaggatcttt ttcaaaacag cggtggcata taaaaccatt 2108401 atcacgaaca gagaaatgaa aggttccgtc ttggctttta caatgtacac aatgattcag 2108461 ctcaggatac aggcccatga caccgagcat cttcatttga acaatgaagg tgataacatc 2108521 cggatctgtt ccttcattca actgttttaa tgattctaat atgaattcaa ataaataagg 2108581 atttggcttt ttttcttctg tgcctctgtc gactaactca gcaacatagg cagcatatgc 2108641 tgttaaaaac aagtcttccc tgatgcctct catgctgagg atcatttccc cctgctgaag 2108701 cgttccgagg cccgatgttt tttgcattaa gaaagaacca tacaaaaagg gctggctgac 2108761 tgctgataaa cggctgttcg gttttttggc gcctcgtgcc ataacaccta tttttccgtg 2108821 ttctcttgtc agtaatgtta cgattttatt cgtctctccg taatcatttg tgcgaagaac 2108881 gatcccttca cattttgtca gcatttccgc accttcctca agcaggagcg gccaagaggt 2108941 ttataaaatt ggataatcaa atcgggctag ctcatcttct agttcttcgg gtctttccat 2109001 gttctctttt tccagttctt taaaaagaag atacgtatca acatttcctg tttgagaaaa 2109061 tacgttccag gtaaaattca acacaagaaa cccacctttc tgtagttaaa ctagcttacc 2109121 taaactccaa attcttacct ttatcttgac cagatgtcct ccatttcatg ttaaacaaaa 2109181 tttgctaatg tatccctgtt cctgtgagat aatgacacac acgggaagag attaatattc 2109241 gtcctcttta aagccaaaat cgcgaagctg ggacatttta ttacgccagt ctttctgcac 2109301 tttcacccac aattcaaggt agacacggga gcccaacagt gcttcaatat ccgctctcgc 2109361 tctttttcca acctctttta gaaggcttcc ttttttaccg atcacgatgc ctttctggga 2109421 atcccgctcg accacaatcg ttgccgctac gtgcacagaa ccgttgtcct gccctttgat 2109481 ggattcgatg gccaccgcaa tgctgtgcgg gatttcttct ctcgtcaaat gcagcacctt 2109541 ttccctgatt aattcagaaa tgataaatcg ttcagggtgg tcagttacct ggtcactcgg 2109601 atagaattgc ggcccttccg gcaaatacgc ttcgatctgc gcgagcaagg tttcgatgtt 2109661 atttccttct aaagcagaaa tcggaacaat ttccttaaaa ggataacgtt tgcggtattc 2109721 gtcaattagc agaagcaatt ggtcgggatg aattttatca attttgttta cgattaagaa 2109781 tacaggcgta gacatcgtct gcaatttctc aatgatgaat tcgtcgccct tcccgtagcc 2109841 ttcctcagca ttgatcataa acaagatcaa atcgacttct tttaatgtat tttgcgccac 2109901 tttcatcata aagtccccaa gtttatgctt aggtttatga atccctggtg tgtcaataaa 2109961 aatggtttgt gatgtgcctg tcgtcagtac tccttgcacc ttgtttctcg tcgtttgggg 2110021 cttatcgctc atgatcgcga ttttttgtcc aatgactctg ttcaaaaatg tagattttcc 2110081 tacgtttggt cttccaataa tggatacaaa tcctgattta aagctttcgt tcgtcatgta 2110141 aatcctccga tgaaaatgcg cctggcaata attcttccac agtcatttct tttatttgtc 2110201 cttgtaaatt agtcagtacg acaataacgt cttttgtgca aagctcagaa atcacctgtc 2110261 ggcaggctcc gcacggagat actggtccag gggtgtcagc cgcaacggcc agcatctgaa 2110321 actctgtatc cccttcagaa acagctttaa ataaagcggt acgctcggcg caattgcaca 2110381 tgctgtatgc cgcgttctca atattgcagc ctctgtacac ttttccatcc ttggtaagaa 2110441 gagcggctcc tacttggaat ttggaatacg gcgcatatgc catatcacgc gcttttaaag 2110501 cttctgttat taattcttgt ctgttcatgt gtacattcct ctcttaccta taatggtacc 2110561 gctatcactt tatattttac ataatcgcgc gctttttttc acgcccattt ctaaaaatgt 2110621 aaaataaatg taagaatttt cagccattac agctttggca aaaaaataag taaaccaatg 2110681 atacacgaaa tcacggcaaa aacgcaaaca gccccggcgg cagcgtcctt ggccgcttta 2110741 gcaagagggt gatgtttgtc agttattaaa tcaaccgtat gttcaatggc tgtatttaaa 2110801 agttcaagcg aaaacatacc acctatcaaa aggaatataa tcatccactc aataatgctg 2110861 agctctacaa ggaagccgca aatgagaaca gcgcaggcgg ctgcggcatg aaattggaaa 2110921 ttccgctccg tccgcgctgt ttcccatatg ccccggcctg catgcacgaa gcttttgaag 2110981 aatcgattca gctcatttct atgatctttt gagtccataa gcgtccagca attccttttg 2111041 cttagtaaac atctcctctt cttcctcttt cgtcatatgg tcatatccta aaaggtgcag 2111101 aaatccgtgt acagctagaa atccgagctc tcttttaaaa gaatgattat actcctctgc 2111161 ctgctctctt gtgcgatcgg cactgatgat aatatcacct aaaaccggag gcatttcggc 2111221 gcccacgatt tcgatctcgc cttctccctc ttcttcaaga gcaaatgaga tgacatctgt 2111281 cggagcatcc tttccccggt attctttgtt aatctgatgt atgtcatcat tggaaacaat 2111341 cgtgacagaa acttcagcct gatcctgaac gccttcacgc tcagcggcaa attgaagcag 2111401 attttctact tctttgagca tctcttctga gacgcttccc gtttcatcaa cgatatcaat 2111461 cagtaaactc atctatttca ccttcttagt agcctccgga tattcaatcc gggagtggaa 2111521 aattcctttt aatgttgcac agagcgtttt tgcgattgta tccagctctt taaatgtcaa 2111581 atcgcattca ctgaactgtc cgtcctgaag cttatcggat ataatacccc ggacaagctt 2111641 ttcaattcgt tcaggatttg gattgtgcat ggatctgacg gccgcttcaa cactgtcggc 2111701 cactgatata attgcggctt cctttgactg cggcttcggt cccggataac ggaactcttc 2111761 ctctgtaatc tggtcgcctt tttccttcgc tttatagtaa aaaaacttta aaagcgaggt 2111821 tccatgatgc tgctcagcaa tatcgacaag ctctttcgga aatttatagc ttctcagcat 2111881 attcgcaccg tctgtcgtat gcgagataat aatatttttg ctcaactgag gtgacagctt 2111941 gtcatgcgga ttgtcaatat tcatttggtt ttcaataaaa tattgcgggc gctttgtttt 2112001 tccgagatcg tgataatatg cgccgactct tgcaagcaaa ccattagccc caaccgcttc 2112061 acaggctgcc tctgataaat tggcaaccat tacactgtga tgatatgtac ctggtgtttc 2112121 cgtcagtatt ttgcgcaata gcggatggtt aggattagac agctcgagca gcctcatggt 2112181 ggataaaatg ccaaagcccg tctcaaaaaa cggcatcaga ccgatgatca atacagatga 2112241 agcaaacccc gacacaaccc ccatgagcat taacgtgccg atttcaagac ccgacagcgc 2112301 agtgttctgg atcaataata aggatagaac gacaaccata ttaataaacg ccacgaaaag 2112361 tccggtctgc aaaatctttg atcttgcatt gtgttttcct aaaaataata cacctgaaat 2112421 gccgctgatc aaataataaa tccctatgac ataattgaat gttcctgtca caccctgatt 2112481 aaacatcata cttccgcaaa tcgcaagaat gatacttccc aaaatggcaa tgcgttcatt 2112541 catcagcagt ttgattaaga tggcgccggc cgcaatgggg accagatagc cgatattatt 2112601 atactccatc ttctgaaaca aactgacaac ctccatgatc acaagcaaaa gtgttgtgat 2112661 tatggagaat aacagaatgg attggttttt aaacttcaga ttttgtttct gtttttcaaa 2112721 ataatataca agtgttgcaa tgaaaagtcc gatcataatc aatagcccgc tgatcggttt 2112781 aaagagattt gagttattta ataacccggt cagctcaagt ttcctgtaca cttcccgatc 2112841 aatgaggtca ttttcttcca cgagcacttg cccctgtttg atttgaacct gctggacatt 2112901 atctgaggct tcctgccgtt ttgcctctgt tgctttcgga tcgaagacgt aattcggaat 2112961 aatagcaaaa cgcccgattt ctgtcgcggc tcccaagtat ttagacggaa tagaattgct 2113021 ctttagctct ttttctacct tatcctttgc atcagatagt ttatccgaag ggatttcact 2113081 gctcatgacc gtatttaccg cggtaatgac cgtatctctg acaaaagaaa agtcttcact 2113141 gtctgctttc agcaatgtct tgatggaatc ctccgatata gaatcattca catctgatgt 2113201 caatttgtcc tttacagatt tgaccattga tttttccgat ggtgatttac tgccttcttc 2113261 cgatgatttt ttcacttcac taatactgtc gaatattgat gacacaaggt caatccgatt 2113321 gtctgtatat tcttttttta atgtatattg atcttcaacc gcgtcctcag cggcttgctt 2113381 tttttcctct gtggcttttt gatcttctac ggttgccgga gcgtaaatgg tcttgtcgct 2113441 gactgaaaac aggtctaaat caagtgtttc cggcttaaca tgtacaaaga gcaaagcaaa 2113501 cataatggca gccagcagaa gatacagcag tacatgcatg gagcgggcat ttttaaaact 2113561 gctccatttt tttgagctgc ttttggtctt agccttcttt ttcaacacaa gaacctcctc 2113621 ttgaaacatc aagcccataa gcaatcataa aaatgacccg ataacgcgcg atcgggtcat 2113681 tcagcattaa ttttgcttat cgtatgcttc aataattttc gcaacaagcg gatgtctgac 2113741 cacgtctgtc tggtctagct caatcataga aatgccgtct attcctttca gcatctcctt 2113801 cgctactgca agtcccgatt tgacgccttt cggcagatca atttggctaa cgtcacctgt 2113861 aatgatcatt ttagagccaa aacccagtct cgtcaaaaac attttcattt gagcaggcgt 2113921 ggtattctgt gcttcatcaa gtataacata agcatcatcg agcgtccgtc ccctcatata 2113981 tgcgagcgga gcaatttcaa tgatgcctct ttccatcaga cgttctgtat gatctgcccc 2114041 aagcacatca tggagagcgt catacagcgg gcgcaaataa ggatctactt tttcttttag 2114101 gtcacctggg agaaaaccaa ggctttcacc ggcttccacg gcaggtcttg ttaaaatgat 2114161 ttttttgata tgtccgtttt ttaaagcatg gactgctttt acgacagcca ggtacgtttt 2114221 cccggttccc gccggaccaa tgccgaatac aaggtcattc cgcttcatag cggccacgta 2114281 ttcccgctgt cccattgttt ttacacggat tgatttgcct tttgcgtttt ttgtaatttc 2114341 ttcttcatac atgctttcaa agtattcaag ttcattcttc tttgccattt tgatggcgta 2114401 aatcacatca cgttcagaga tctctatccc cttgcgaatt aaagcgagga gcgatcccag 2114461 cagcctgtct gcaatctgaa acgattcatc atcgcctgaa acataaatcg tctcgccgcg 2114521 cgtaatgata tttaaattca gatctttctc catcaatttc aaaaaagaat cttggttccc 2114581 gaagagtgaa agcgcctcgt ccgggttttt cagtttttga ttcatcgcaa gtaaatgttc 2114641 tgtcattctt cagtctccct gacaataggt gtggtttgaa cgatatcttc tataacttgg 2114701 tagagaataa tcaactttac tttaccattc tcaacagtct ggtgcaaaac tttttcactt 2114761 ttcacctcgc cgttttcgcc tattttatcc tctacatcct gtttacccaa tttaatgcct 2114821 tcttgaactg cttcttcttt tgtatatttt cgcaaagcct cttcactttc tctcgtttgc 2114881 tctttgacat aggatacagg gagcttaaat ccgagaaaat gaagcgaatg cttttcttgt 2114941 tctgtttttg gatgcttcaa ttcctctttt ttaaacgtca tcccccagat cgggattgcc 2115001 aaagaaccaa aagaaagctt gtgctttgtc cttactttgc ccgtatagac gttaaataat 2115061 gtttcaagcg ggactgtcac ttctgatcta taccaggttt ctccataaat ttctgctttt 2115121 gaggcgactt cctgctgatg gtcttcgctg ccgatcagtc ccgaaacaag cagctgtccc 2115181 ttttcaacat gatcgtgtat ggcggccatg ggctgtcctt tttgcacaaa cattctcgta 2115241 atggttgctt tctttttggc gacaatattg cgcgggctaa catatttttc tttttcgggc 2115301 tcatttttct ccacaacttt catatgaatg gtcgtcccct tcagatcaac tccgacccaa 2115361 gtgatattgt ctattccatt ggttaatgat ttctgtattt tttcgggcga catcattaaa 2115421 aactgcagac ggcccttttt gacgccgatt tcattaagat gctgcctcat ttgatgttct 2115481 gtttcaggct tagcgcctgt cacatcaatt ttccacacca tattggacag caaaaacaaa 2115541 agaatgaaaa aaatcgcaaa accgatcgta aaccctatat tcagctttga tttcagcaac 2115601 aggaagggaa atcccttccg attgataaat cgggctttac atttaaattt acttcttacc 2115661 cgccgaaagg catgtacatc ctgaagctgt atatataacg atacggcttc tttctttttt 2115721 ttgacatgaa agaccggaat cccctgtctt gtgcattcat taaggagccg ctcaatccct 2115781 cttcccgtca attcaagctg gaccttaccc gaaaaaaaag acagccattt atttttcaca 2115841 acatttcccc ctcggcttta tgactcaaca tatcgaacga catcaatcgt accctccaaa 2115901 agtatctctt ccggaagaat cgccttgatg acaaaatttt taccagatat gatgcactgg 2115961 ccctgcttca gcatcagccg cacttcattc tcactgaaaa gcaaaaggcc tctgtggttt 2116021 tctatgtaga tatgaagtct gccaaccatt gtaatcctcg gcagatccat cataacgtcc 2116081 gggggaattt ccaatgctct tgtcagccaa gctttcatac gattctttct ttgccccata 2116141 caaaaagaac cccctttcat ctcatatgta tgatttgaaa ggaggttcta acactttaat 2116201 ttttacgggc cgggcgcatc gtacggtgag gttttttcgc ccgtggaggt ccgaacacct 2116261 ctcctagaac gatcccctgt acgacggtgt ctttattcac ctgaagcatt ttttgttttg 2116321 tgtatactgt tttttgtttg gcagcagcaa gatctcgttc cagccctttc aggtttcttg 2116381 ctgtttccct gcgtctttct tccgcttccc gtcttgcctg ttccatacgg ttagggatag 2116441 gtgcaggggc atcttctttt gactgcttct tttgaggaga agcagattgc acgtgttgag 2116501 gtttttttct tttttggctg ttttgctttt cttctttgct ctttttgccg aaaatcgcag 2116561 aaatgattcc gatgatcgct gcaataataa gcggattggt cagtaaatct tccatcagcg 2116621 ttctcccttc ttagagagat tatgatttgc ggtcttcatc cgaagggtct ttcgtcagct 2116681 tgccgaatga atcacgcatt tctgtgtcag catcgatgtt cttgatattc atgtaatcca 2116741 tgacgccaat attcccttca cgcaaagctt ctgccatcgc aagcggcact tccgcctcgg 2116801 cttctactac tttcgcgcgc atttcttcta cgcgggcacg catttcctgt tcttgagcga 2116861 cagccatcgc acgtcgttct tccgcttttg cctgcgcgat gtttttatca gcctcggcct 2116921 gatcggtttg taaaattgcc ccgatgtttt tgccgatatc tacatctgca atatcaattg 2116981 agagaatttc aaacgcagtt cctgagtcca atccttttcc aaggactgtc tgagaaatca 2117041 tgtcagggtt ttcaagcact tttttatgat tatcagatga accgattgta gaaacgattc 2117101 cctcacctac acgagctaca atggtttctt cccctgctcc cccgacgagg cgctcgatat 2117161 tcgctcttac tgtgattctc gctttcgctt tcacttcaat cccgtccatt gcgacgccgg 2117221 caatgaacgg tgtttcaatc accttaggat taacgctcat ttgaacagct tccaacacgt 2117281 cccggcctgc aagatcaatg gcagcacagc gctcgaatgt gagttcaatg ttagctcgct 2117341 gagcggcgat aagcgcgttg acgactctgt caacattacc tccagccaga tagtggcttt 2117401 caagctggtt tgttccaaca ttaagtcccg ctttatgcgc tttaatcagc gggttaacaa 2117461 cccgattcgg aatgacgcgg cgaagcctca tcccaactag agtgaaaatg ctgattttca 2117521 ctccggctgc caaagctgaa atccaaagca ttacaggcac aaatgtaaaa aatactgcca 2117581 aaacaatgat cgctactgcg acaattgcca gaatcataag tgttgacgga tccatataac 2117641 ttctcctcgt ttctatttaa atttctctca cgacaatgcg tgagccttct acttttatca 2117701 cttttacttt tttatctttt tctgtaaacg atccctccga tacaacgtca aggcgttcat 2117761 catcaataat cacggtaccg gaaggacgca gcggtgtaaa ggttataccc acttttccca 2117821 ttaagtccgt gcgcgtttga tttgaaacgt agccgctctc cgtgtttgta gaatcattta 2117881 atatcaattt cttaaagaat ttcatacgct ttcccaacac ccttgtcagt aaaataaaag 2117941 ctgtaatcga aacagctgag gcgatcaaga gagaaaccgc catgacagtg aagctccccg 2118001 cggctaaaaa caggctcgca ataatcgctc ccaagcccag taatccaatg attcctccgg 2118061 gaagaaaaat ctcaagcaga atgagaatca cccctgctat aaagaggaga accgtctcat 2118121 acccggcaag gccggctgca agatgcccgt aaaagaacag caataacgca atgagtccag 2118181 ccgttccagg gaggccgaca cccggggaaa aaagctctac cgtcagacct aaaaaagcga 2118241 ttgtcagcag aatagggaca atgaccggat tcgtcagcca tcttgccgtc ttttccgcaa 2118301 agctctcctt tgcatagctg atctgcgcct tttcgaaccc aagcttcttt acgagcgtgg 2118361 acaaattgtc agcagtgcct tctgaatagc ctacctcaat cgccttgtct gcgttaagtg 2118421 tcagcagatc tcccttaggc gcgccaactt ccttggcatc tatatctggg tcagccattg 2118481 cgagcgcata ttttggatcg cggttatttt tcactgcggc atcttccatc tctgccagcc 2118541 aaagtgattg agctttttgg tcagcggcat tgccttggcc atcaacaatc gcggcggctc 2118601 ccatttttcc gccaggcgcc atataaatgt gatctgcttg aagtgcaata tatgcaccag 2118661 cagacaacgc gcgtttgttg acatatgcag ttacggggat ctcgctttcg gttatcaaat 2118721 cggccatatc aatagcagat ttgaccaatc cccccggggt attgatatca agaataatat 2118781 ggtctgcatg tgcatccttt gcgtcttgta acgaacggga caaaaacgag gcgagaccct 2118841 gttcgacatt tttttcaacc gggatcacat aaacagtttg tttttctgct tttgcgttca 2118901 gctgtacgcc taataaagaa agtaaaaata tacccaaaag agcagcacgg aatcctttga 2118961 tttgaagcaa gggcggtgta tccctccttc cttttataat aagtgccttc tcttcatacg 2119021 taacaaatgt atcaaaggtt tcattttttt atgtataaaa aaagacatct ctcttagaaa 2119081 gatgtccttt tctttgccat ttaagacagt tgactgctca caagcttatt aattaaactt 2119141 ccgtcagctt taccttttac tttaggcata attgccccca tcactttgcc catgtccgct 2119201 tttgagctcg caccgacctc cgcgatggtt tcatttacga ttgtacgcag ctcttcttct 2119261 gacagctgct caggtaaata aacttctaaa atgtccagct ctttttgaac tttatctact 2119321 aaatctaaac gattagcgtt tgaaaattcc tggagggagt ctttacgttg cttaagttca 2119381 cgagaaagga cagtgagttc ctcatcctcg gtcaaactgt ctttcttaag cttaattgct 2119441 tcattttgaa gtgaagcctt aaccattcga acgacagtca gtttgtcttt ctcacggttt 2119501 ttcatataca gcttcatatc ctggttgaga cgctcaagaa gactcataaa tccaccctct 2119561 tttagaattt gcgttttcta gcagcttcag actttttctt gcgctttacg ctaggttttt 2119621 cataaaattc acgctttctt gcttcttgca aagtacctgt ctttgataca ctgcgtttga 2119681 agcgacgaag agcatcttca agcgattcgt tttttctaac gaccgttttt gacattctct 2119741 ttccctccct ccgaatacac caatcgacta cctttaagtt acacatataa acatgtactt 2119801 tgacattata atataagcca tcagtcaggt caactaagtg agttcacttt tccgtcatga 2119861 gtgcgactgc ctgtctatat aatgaaagaa aggggttggt gaataggatg ttaattctga 2119921 ttagctttac tgctcttata ttattctttc tcgcaggcat gaacatgctt cgaaagggct 2119981 taatttcaat ggcgtactca aaaattgaag aacgtttgct tttatttaca gaccatccgt 2120041 taaaagcgtt tcttatcagt attgtattta cggggatact tcagagcagc tcagccttta 2120101 tggtcattgt catcggcttt gtaagtgcgg gcgttctttc ttttaagcgg acgatcccga 2120161 tgattctggg gacaaatgtt ggctctactt ttacaactga atttattgct atcaaaatgg 2120221 atattgtgat ttgggttctt ttaataggag gtttattgtt ttttctgact ggcaggtatc 2120281 ctttgaaaca gctgggaaca agcttccttg gactgggcat catcttcttt tgcatcagcg 2120341 gattcagcca tcttgccggg ccgctgacaa agctgaaaac gggcgccgac gttctatacc 2120401 atgttaacga ttcaaactgg tccgctttgc tcatcggcat ggtgttaact gccatcattc 2120461 actccagttc tgtctgtatc ggcattttga tgagttttat gaatgaaggg attatcggac 2120521 tgacacaggc gatgagcgtc gtactcggat caaatatcgg gacatgcatt acagctgtca 2120581 tggctgctgt atccggcgga tatgcggcga aacagacagc atatgcccat gtggtattta 2120641 acgtgctagg ggtggctcta gtattgcctt ttctgaccgc agcgaccggc tttgtagagc 2120701 agttatcacc tgatcccgca caaaagatcg cgcatttcag ccttttattt aatgtggtga 2120761 cagctctttt atttcttccg cttacaaact tgttttaccg attgattcac cttcttatcc 2120821 cggctaaata aaaaaatcgg tacattttaa tgcaccgatt ttttaggtta agaagacaaa 2120881 cgcatgtgtt cagttatttc atcctcaacc acacggacaa actgtccttc gttgtaagga 2120941 taacctgctt ttaggatttt gacttttacg attttgccga tcatatcttc cgtacctttg 2121001 aaaacaacct tcatataatt gtctgtgtaa ccgacaaaca tattttcttc ttctgtttcc 2121061 ttaaacgctt cctcagggat aatctcaagc acttcatttt catactgaga agcgtattct 2121121 tttgcaagct ggtcagaaag agcaatcagg cggtgcacac gttcgttttt cacgttttca 2121181 tccacttggt cttccattcg tgcagctggt gttcctgtac gcttactgta agggaaaaca 2121241 tgcagctcag agaatttatg ttctttaata aagttatagg tttccataaa ttcttcttct 2121301 gtttctccag ggaacccgac gatgacatca gaagtaacag ctaagcctgg cagtgctttt 2121361 ttcaatttat ttaaacggtc tgcaaagaat tccattgtat atttgcgtct catccgttta 2121421 agcactgtgt ttgatccgga ttggatagga atatgcaaat gattcactat cttatctgag 2121481 cggtctaaga cctcgatcac ttcgtcagtg atttggctgg cttcgattga agaaattctg 2121541 atccgtttca cgccttccac acgggtgtct aattcgctca aaagcttcgc gaagttgtaa 2121601 tctttcatat cttcgccgta gccgcctgta tgaatacccg taagaacaat ttccttatat 2121661 ccggcatcga caagctgctg cgcttgttta atgacttctt cagggtcgcg ggagcggagc 2121721 aggcctctcg cccacggaat gatacagaat gtgcagaaat tattgcagcc ctcctgtatt 2121781 ttcaatgacg ctcttgtgcg gtccgtgaaa gcaggcacat caagctcttc atatactctt 2121841 gctttcatga tgttgctgac gccattaatc ggctggcgtt cttctcggta ttggtcaatg 2121901 tagccaagca ttttttcacg gtcctgtgtt ccgactacaa tgtcgacacc ggggatcgcc 2121961 ataatctcag caggtgaggt ttgcgcgtag cagcctgtga cacagatgac accgtcagga 2122021 ttttgacgaa tggcgcgtct gatcacttgg cggctttttt tatctcccgt atttgtaacc 2122081 gtacatgtat taatgacata tacatcagct gtttgttcaa agtctcttct ttcatagccc 2122141 gcttctttga aaagctgcca gattgcttct gtttcataat ggttgacttt acagccaagc 2122201 gtatggaaag caacagttgc cattactgat cacctcttaa taactctgtt tgataagaaa 2122261 tcgcactcaa cgcgtatagc ggagcggttt ctgtccttaa aattctcggt ccaaggccgc 2122321 acgtcacacc gtcttgctct gtgagccgtt caacctccgc ttctgttaaa ccgccttcgg 2122381 gaccaaatac gatcaataga gatgatcctt tcggaaggct gcttacaatc gcgctgaatg 2122441 cgcttatttc cccttgcttc gatgactcct cgtatgcaac gacacattta tcgaaatcct 2122501 gcatcctttg aagaagctgc tgaaaagaat ggacatccat cactcgcggc acttcgttac 2122561 ggtacgattg ctcagccgct tccttcgcaa ttttcgtcca tctttcccgc tttttctttg 2122621 cctttttgtc atccagcttg acaacagaac gcgcggcttg gaaaggaata aaggcatgag 2122681 ctccgagctc agtccccttt tggataatcc attcaagctt atctcctttc ggaaggccgc 2122741 tcgcaatata gacctttatc ggaagctctc tgttttcatt cgtccattct atcacaaggc 2122801 aggacacttt atctttggaa acagattgaa gttcacattt tgcctcgaag ccgtcttgag 2122861 agcagcagat aatctgatct ccctcattca ttctcatcac gttcacaata tgatgaactt 2122921 cttcgccggt aatcgaaaaa gtcggcgctt cctctatttg ctgcttcgtg agctcgataa 2122981 aatatcgttg catacgctgt gacacctact aactgttatt ttttcgcaat aatgctgacc 2123041 caatcttcca ttgaaaggat ttctacaatg gtaaagccag cttgttccag tgcttctttt 2123101 acttcttgtt ttttatgacc gatgattcct gacgtaataa agtgaccgcc ttcttttaac 2123161 aggctgtacg cttgtgaagt aaagcgaaga atgacttcag ccaaaatgtt ggccacaatc 2123221 acatcatgtt ccccttcaat cccgtctaac aaattgtttt gcttcacttg agcaatatcg 2123281 ctgactttgt tcagcttgag attgaggcgt gcactttcta cagccacggg atcaagatcg 2123341 taggcatgaa ccgattcagc ctcaagcatt gcagccgcaa tacttaaaat tcccgaacca 2123401 gtgccgacat caatcacctt atcacccttt tgcacaaagc gttcaagcgc ctgaatgcag 2123461 agtacggttg tcggatgtgt ccctgtgccg aaagccattc ccgggtccat ttcaataatc 2123521 agttcatcag tatggaccgg cgtatattcc tcccacgtcg gcacaattgt aaacttttca 2123581 gaaattttca caggatgata atactttttc caggcagtcg cccactcttc ttcatttact 2123641 tcagaaatag tgatgtggtt tctgcccaaa tcaatattgt aaagaaggag attattaatc 2123701 gtttctttga tgccgtctac agtttcgccc agaaaactgt taaccggcag atatgctttg 2123761 acaatgacac cctcatctgg gtaatcattg gggtcgagct ggtagatttc cccgtacaca 2123821 ttctcacgtt ctttaattaa atcaagcggg tcctctatca caaccccact tgcaccagct 2123881 tcatgcaata tatttgagat aggttcgacc gcttcatgtg ttgtgtgaat gcttaattcg 2123941 gaccatttca aaactaccaa ctcctcatcc aataattaat cgcctttaaa cgcgcgtttt 2124001 accttgtcaa agaaactcat ttcctgttcg tcaggcaggt ttccgctgac ttcggcaaat 2124061 tcgcggataa tgtctttttg tttatcagtc agatttgtcg gcgtaacgac gcggacgacg 2124121 atatgctggt caccctgtcc atagcctctg acattttgaa cgcctttgcc tcttaatctg 2124181 aatttcgttc ctgtttgtgt accggccgga attttcaatt tcacttttcc atgcagcgtc 2124241 ggcacttcta cctcatctcc aagagcagcc tgagcaaacg ttaacggcat ttcacagtaa 2124301 atatcatcgc cgtcacgctc gaagaactcg tgtgcgcgta catggaacac gacaaataaa 2124361 tccccggcag ggccgccgtt tattcctggt tcaccctgtc ccgagagacg aagctgctgc 2124421 ccgtcatcta caccggctgg aattgtcaca ttgattttct tgcgtttttt gatttttcct 2124481 ttgccgccgc agtccgcaca tttgttttta atgattttgc ctgtaccttc acagtggtgg 2124541 cagacccgtc tgttaacgac ttttccaaac ggtgtatttt gctccacgtt taactggccg 2124601 gagcctccgc agtgggagca tgtttctgga tttgttccag gtttcgcacc tgagccttta 2124661 catgtttcgc acgtttcctc gcggggaatt tcgatggttg tttctttacc gaaagccgca 2124721 tcctcaaacg acagggtcat cgtatactgt aaatcagcac cctggcgcgg agcgtttgga 2124781 tctcttcgtc ttgtgcctcc gccgaatata cttgagaaaa tatcatcgaa accaaaaccg 2124841 ccgaaatcgc cgccgccaaa acctccgccg ccgaagcctt ggttagggtc agtgtgacca 2124901 aattgatcgt aatgcgcacg tttttggtca tctgacagcg tttcgtatgc ttcttttacc 2124961 tctttaaatt tttcatctga tccggcttct ttgttaatat caggatgata tttttttgac 2125021 agcttccgat aagctttttt aatttcatcc tttgaagcgc tcttacttac tcccagcact 2125081 tcatagtaat cacgcttact catctcgctt cactctcccg aatttctcac ataaattaga 2125141 ttgtatcatt ttgaattatg atttttcaat tccttttatc ccgggcaaga aaaaaagtca 2125201 aagccaagag atgcctgact ttgactttct aatcattgaa tcagattatg aaatgtgttc 2125261 ttttcggtca gctccggaag cggggctgac actaaaaaga acttattttt tgttttggtc 2125321 gtcgtttact tcttcgtatt cagcgtcgac aacgttgtca tccgctttgc cttcagcgtt 2125381 tgctccgcct tgagcttgct gtgctttagc agcttcttca taaagcttca tagaaagctc 2125441 ttgaacgatt gtttgaagct catctttttt cgctttgatc tcttcaaatt cgtttttctc 2125501 aatcgctgct tttaaagcgt ctttggcatc gttggctttt ttcacttgtt cttcgtccac 2125561 tttgccttca agatctttta atgttttctc agtttggaaa acaagctgat ctgcttcgtt 2125621 gcggacttcg atttcttctt ttttcttcgc atcagcgtca gcattttctt ccgcttcttt 2125681 taccatgcgt tcgatctctt catctgagag acctgaagaa gatttgattg taatgttttg 2125741 ttcttttcct gtgcctaagt cttttgctct tacgtttacg ataccgtttt tgtcaatatc 2125801 gaaagaaact tcgatttgag gcacgccgcg cggtgctggc gggatatcag taagctggaa 2125861 gcggccgagt gttttgttgt cggcagacat tgggcgctca ccttgaagaa catggatatc 2125921 aacagctgtt tggttatcag cagcagttga gaacacttga gatttgcttg ttgggatcgt 2125981 cgtgttgcgg tcgatcagtt ttgtaaacac accgcccatt gtttcgatac cgagagaaag 2126041 cggtgtaacg tcaagaagaa caacatcttt tacgtcacct gtgataacgc cgccctgaat 2126101 cgcagcacca agcgctacaa cttcatccgg gtttacgcct ttatgcgctt cttttccagt 2126161 ttcttttttg attgcttctt gtacggcagg gatacgagtt gatccgccga caaggatgac 2126221 tttgtcgatt tcgcttgcag aaagtcctgc atcttgaagc gcttgacgga caggacccat 2126281 tgtgcgctct actaaatgag aagaaagctc ttcgaattta gcgcgagtta atgtaagttc 2126341 aaggtgaagc ggtcctgctt ctccagctgt gataaacggt aaagaaattt gcgtagaaga 2126401 tacgccggaa agatcttttt tcgctttttc agctgcgtct ttcaaacgct gaagcgccat 2126461 tttgtctttt gacaaatcaa tgccgttttc ttttttgaat tcagacacca gatgatcgat 2126521 gataacttgg tcaaaatcgt ccccacccag acggttgtcg ccggcagttg aacgaacttc 2126581 gaatacaccg tcgccaagct caaggatgga aacgtcgaat gtaccgccgc caaggtcgta 2126641 tactaggatc gtttgatctt catctgtttt atcaagtccg tatgcaagcg ctgctgcagt 2126701 cggctcgttg atgatacgtt ctacttcaag acctgcaatt ttaccagcgt cttttgttgc 2126761 ttgacgctca gcatcgttaa agtatgcagg aactgtgata actgcttttg atactgtttc 2126821 gccaagatag ctttcagcgt atgatttaag gtgttgaagg atgatagcag acacttcttg 2126881 tggagtgtaa tcctttcctt caatttcaac tttataatca gtacccatat gacgtttgat 2126941 agacataatt gtgttagggt ttgtaataga ttggcgttta gccacttccc ctacttgacg 2127001 ttcgccgttt ttaaatgcaa caactgatgg cgttgtgcgg tttccttcag cgttagcaat 2127061 aactttaggc tcgccgcctt caagcactgc cacacatgag tttgttgttc ctaagtcgat 2127121 tccgataact ttactcactt gaataacctc ctgctatgta attattgatt cactttgacc 2127181 atggaagggc gaatgacgcg atccttcagc ttatagcctt tttgcatttc ctcaacaaca 2127241 atgttggagc cgtagttttc gtcttcagcc tgcataacag cttggtgcag attaggatca 2127301 aattcctgcc ctacagcttc gatggcttcg acgccttctt ttttcaaggc ttctacgagc 2127361 tgacggtgga ccatttccat tccctggagc aaacttttcg tctgttcatt gtcggcttca 2127421 acctgaagcg ctcgttcaaa actgtcaaga gccggcagca aatcagtcac gatattttga 2127481 gaacggtatt tttgggacgc ttccatctct aaacggctgc gtcgtttata gttttcaaag 2127541 tctgcttgaa cacgcaaaag tttgttttct ttttcctcaa gcaaaccttg caattcgtta 2127601 atttggtttt gaagaagttc gctttcattt gtttcttcct gctgttcatc agcggcagct 2127661 tgttcttcaa tgatttcttg ctcttctgtt tcgttttgtt caacggtttg tttttcttct 2127721 gacattgtgt tcacctccct caaagtgtaa ggagaaggac aggtgctgcc cttcgataaa 2127781 atttgccaaa attcccttat tcatcataca gacttgttaa tgcttttgac aagtccgaag 2127841 tcacatgctg aagcaggctg acaaccctgg aataattcat gcgggtcggg ccgataatcg 2127901 caattgagcc gatctgcttc tggtctacgg aataagaagc cgtaatcaga ctgcaatttt 2127961 ccatctcttc atagtcgttt tcttttccga ttttaatcga aattcccgtg tgcggggatt 2128021 gaaccagctt taaaacatcc tgttctttct caattaatga aagcagcgac cgaactcggg 2128081 tgatatcatg gaactcaggc tggttcagca tattgatttt cccgccaaaa aacaactttt 2128141 caacgtgatt tgtggaatga aaggttgaac gaagcgcgtc gagtatattg tcatagtttt 2128201 taatgtgctg tcttaggtac atgacaactt ctttaaatat gcgctcattc agttcatcca 2128261 ttggaacgcc gcttaaacgg tcgttcagta tatttaccag tttttcaata tcagacagat 2128321 ccattttggt cggaaagtta atcgttttgt tttccacatg ccccgtattg gtaacgagaa 2128381 tcgctaccgc catatcaggc tgaatcggaa tgatttgaat ctgtttaagg taattctcac 2128441 tcaacttcgg cccgagtacg atggatgtgt aattcgtcag atcggacaaa atttgcgctg 2128501 atttttgaac tgtcttctcc agctcgaaaa ttttctcttt gaagatcgag tggatttggt 2128561 ccaggtcgct tttcgtcaat ttgacgggtg acagcaaatg gtcaacatag taccgatacc 2128621 ctttttctga cggaacacgt cctgaggatg aatgggtttt ttcaataaag cccaattcct 2128681 ccaagtcagc catctcgttt cttattgttg cagagctaaa tgtgatttca tcttttttcg 2128741 aaagagttct tgatcccacc ggctgtgccg atttaataaa atcgttgatt ataacctgaa 2128801 ggatcagcag ctgacgattt gttaacatca tcatcacctc tgttagcact ctcaataagc 2128861 gagtgctaat tctataacaa aagtatcaaa ccacaagaaa aatgtcaatt ataactcacc 2128921 caaaaaagcg ccaaaaactt cattgcctaa taatttccct tgatgagtca aataaacggc 2128981 agactccgaa ttgtgaatca gccctttttc agcgaggtct tttaacacgc ttgggaaaag 2129041 tccatccagg gaacggccgt atttttctgc gaatcgtttt ttgctgacac cggctgtttt 2129101 tctcaaacct aaaaacattt cttcctcaat ctgttcttct gttgtcactt catgtgtatc 2129161 tctgtacgga aaaccctttt cagctatcag gtcaatgtaa tgcttaacag gtccgacgtt 2129221 cactgttcgt gtgccgccaa tatatccgtg agcgccagct ccgaaaccga aatattgttc 2129281 gttgctccaa tacgttagat tgtgcttaga ttccatgcct gccttagcaa agttgctgat 2129341 ttcatattga tgaatgccgt gagcttccat cttgctcatc actatttcat acatttcagc 2129401 ttcctgctcc tgcggcggaa gatgaagccg ccctttttgc atcaaattat aaaataccgt 2129461 tttcggttct acaataaggg agtaaacgga ataatgctca gcgtccaatg ataaagcagt 2129521 gtttatggaa tgttccagat gcttgagggt ttgccccgga agcccgaaca tgagatcaag 2129581 actgatattc tcaaaaccga tttcccgcgc tctttcaaaa gaggtgaata catctttttg 2129641 cttgtgcact cggccgattt tttctaacag atcgtcttcg aacgtttgca caccaaagct 2129701 aaggcgattt acgcctgctt cttttaatat ttttaatttc tctgcggaca aatcgtccgg 2129761 attcgcttca accgcaaatt ccgataagtc gcttgagggc tttagcacgc ggttgatcat 2129821 atccatcagc tttttaagct gttcctcaga cagggaggtc ggcgtgcctc ctccgataaa 2129881 gattgttttg agatcaggct gcccggtttt tgctattgta tttatcattt cctgttcgag 2129941 tgcgtttaaa tactcgtcga ctggctgact ttgaataaaa tatttattga aatcgcagta 2130001 gtggcaaata tgctcacaaa atgggatatg gatataagct gatttcaacg gattcacctt 2130061 ctttacagaa agaagccgca gtacaagact gcggcggctt ctattgtttt ttcggactgt 2130121 cgtccatttt cagaactgcc ataaatgctt cttgcggcac ttcaactgag ccgacctgct 2130181 tcatacggcg ctttccttct ttttgttttt caagaagttt ccgtttacgc gagatgtccc 2130241 ctccgtaaca tttagccaat acgtttttac gcattgcttt tatggtggag cgggccacga 2130301 ttttctggcc gattgcggct tgtaccggaa cttcaaactg ctggcgcgga atgagttctt 2130361 tcagtttttc aacgatcact tttccccgtt catatgcgta atcacgatgc acgataaagg 2130421 aaagggcatc gattttttca ccattcagca taatgtccat tttcacaagc ttggacggtt 2130481 tgtagccgat cagttcataa tcaaaggacg catagccttt agtgcttgat ttcagctgat 2130541 caaaaaactc atatacgatt tccgctaatg gcatatcata aatgatgctg acacggtttg 2130601 cgtctaaata ctgcatatca atgaaattgc cgcgttttcc ttggcaaagc tccattacag 2130661 cgccgacata gtcattcggc accatcatcg tcgcttttac gtatggctcc tcaacccttt 2130721 cgatcttttg aggatccggc atgttggacg ggttgtcgac aacgaccttt tcgccgtctg 2130781 tcatatacac gtcatagata acgcttggcg ctgtcgtaat caggtcgatg ttgaactcac 2130841 gctcaattcg ctcctgaatg atctccatgt gaagcatgcc taaaaatccg cagcggaacc 2130901 cgaatccaag cgcttgcgaa gtttccgctt catattgaag ggaggaatca ttcagctcaa 2130961 gcttttcaag agcttccctt aaatcattat acttcgctgt atcaatcgga tacaaaccac 2131021 agtacaccat cgggtttagc ttgcggtatc ccggcagcgc ttcttctgca ggattggcag 2131081 cgctcgttat tgtatcaccg acacgtgtgt caccaacatt tttgattgag gcagtcagga 2131141 agcctacatc accgaccgtc agttcatttg tcggagttgc tttcggcgtg aacacgccca 2131201 cctctgttac ttcgaattct ttgccggttg ccatcatttt gattttttgt cccggcttta 2131261 ccgttccttc aacgactctg atataagcca cgacaccgcg gtaggcgtca taaagcgagt 2131321 cgaagatcag cgctttgagc ggcgcctccg gatctccggt cggagctggc accttttcta 2131381 cgatttgttc taaaatctcc tcaatcccga taccggcttt tgctgaagca agcacggctt 2131441 ctgatgcgtc aaggccgata acgtcttcta cctcttggcg cacacgttcg ggctcggcgc 2131501 tcggaaggtc gattttattg atgaccggaa ggatttcaag atcgttgtca agcgctaagt 2131561 agacattggc gagcgtctgc gcttcaatcc cctgggctgc atccacgaca agaatcgctc 2131621 cctcgcaggc agcaaggctt cgggatactt catacgtgaa gtcgacgtgt cccggcgtat 2131681 cgattagatg aaagatatat tcttctccgt cttttgcttt atatttaagc tgaacagagt 2131741 ttaatttaat ggttatgccc cgctcacgtt caagatccat agaatcgagc aattgttctt 2131801 tcatttctcg ttgagtgatt gccgacgttt tttctaaaat acgatccgct aaggtcgatt 2131861 ttccgtggtc aatatgggca atgatagaga aattccgtat tctcgattgc ctctctaaac 2131921 gcttttcttt atctgtcaca atctatcact cctactatta aacgcaaaat acactagctt 2131981 agattatatc aataggattg taaagattca atgtaaaaca agaaagagaa aagttcccta 2132041 tcatatctgg gttgcttttc tctttcacgt acttattgat tcatatcccg tatccattca 2132101 tacattgact gggcagtatt ggttacggtg tccgaaagcg cttttccggc ttttgaaaac 2132161 atattgaatg tctccacctt ttccagctct ttttgttttt ctactaaatc ttttgccgtg 2132221 actgtttctc ctaggattga ggcttctttt tcattatctt ttccgtcggt gagcgtaaac 2132281 gcccccttca gtgaagggtc atgatagcct ttcatactca gcatcccgtg gtttgcctgc 2132341 tgcatgccga acagaacgcc taaaaacatg atcgtgacaa gcagtaagca ctttccaaag 2132401 tatgcaatca aatcaaccac ctatttctta ttgttttttc gtctccccgc tcgctgcgtt 2132461 gaccttttca gcatcccagt acatttcgct gaatacgtcc gcggccgcgt tagccgcacg 2132521 ctgcagctct tcgagattat tatccactcc gccaaactcg agcaaaagcg ctctatcggt 2132581 taaatcctga ttgtaaacac cattatcgcc tggcgagcct ttggaaaaga cacctgtgct 2132641 aagtccgggg tattttttct ccatcagttt atgaagctca ctcgcaattt tatagttttc 2132701 ttcgaagttt ttgctttttt tcccgacgac aaaggctacc ctggcatagc ttttcccttt 2132761 aatcgttgcg gttgtgtctt ttttgcgccg agagtctctg tggatgtcaa tgatatattg 2132821 cagatttttg tttgaagcga gggcgtcttt cacgaccggc cttgattcat cataggacct 2132881 ggcatagttt aagccttttt tattcaattt tgactgtata tcggttttat tcactgtggc 2132941 tccgattccc tgggattcaa gcgcttgtcc gaacatatct cctacaagcg tgacattggc 2133001 tttagaatgg cgcgccatgt caggatcggt ctcgcctttt aatagaggga gatatgattc 2133061 cgtattgtgc gtgtgataga taaacacgac ctttttatca cctgttgttt gtttcggcgg 2133121 atctttttgc gcattatctg attgcgtttg ctgtttttca atctctgcca aattcgcttc 2133181 tctttcttcc tccatcacct tagacggcgg cggcgattcc gcaggcatat tcgtataatc 2133241 cgttccttgt ccagctaaca aaatctcggt atcaaattgt gcaaatcctg gcagctcccg 2133301 accgagaaag ctccgcggat cttcgaggtt aatgctcgtc gccagcttta aagaaagacg 2133361 agaaagatga aatgagctgt ctgtttgaga gaggtcagaa gcgaaataat ggttttccat 2133421 ctgcagcaaa tgtgcaaata cgtcacccgg caattcttca gcaatcccat aaaaagagtc 2133481 agacgacggc ctaagttccg gccggagaga cgtcagcaca ccggatagaa caaaaatcac 2133541 gataaggctt acgataaata gaaagatggc ttttaccgct ttccctccat ttaccgcaac 2133601 aacaatctgt ctgtttctgc gtttatttct cattgaatcc ctccagcgct tgtctagtaa 2133661 ttactctatg aacaagctag aggaagtaga actgtttagt gattgtagga gcctttgttt 2133721 tcttgtgaca ctttttcatg aagcgctgtg tttaatccgt tcgctaaaac atttgccata 2133781 tcgtcgataa atgaatcgac ttccttcggt gtaaccatta agttgtgccc taaaggcgaa 2133841 agcacctcgt gaatgagctg ccgtttttca tcttcttgaa gggttccgac aatacctagg 2133901 aacgattggc gctgcttttg atcgggaaga tcgtcttcag tgagcacttt ctttttccca 2133961 aacgtcatgc ctgccggaac aagcgatctt gatggcctgt tatccttcat ttctctgcca 2134021 aaatgtttta atatgtagtc caccgtgtcg ctggcaattg tcacggcatc aactactgtc 2134081 ggaacaccga tagcaatcac cggaacacca agcgtgtctt tgcttaaatc ttttcgttta 2134141 ttccccactc cagaccccgg gtgaatgcct gtatccgata tttgaatggt tgtgttgacc 2134201 ctttccaccg cccgcgccgc caacgcatca atggcgatga caaaatcagg cttcgattgc 2134261 tcaatcacac ctttaataat gtcacttgtt tcgattcctg ttatccccat tacacccggt 2134321 gcaaaagcac tgacaggcct gtaaccctcc tgtacgtttt ccggctgaag cttaaacaag 2134381 tgccttgtta ccaacagatt ttctactgcc atcggtccaa gcgcatcagg tgtcacgttc 2134441 cagttgccga gcccaacgat caaacagctc gcatcttttg agatattaag gttttcaaga 2134501 aaagctgaga attcctccgc aaagacagca gagaccttct cctgcatttc cgaatcattc 2134561 tccctgattc cctgtgcttc aagcgttaaa tagcgccctt ctttttttcc cgaaagctct 2134621 gcgccttcct ttgtaacatc aactgtgcgg attttaatgc cgccgtgatc acgctctttt 2134681 tcaataaagc ctttaatttc ttttgtcggc acagcctgct gattggccat tgcttccttc 2134741 gtttccactg ccaaatcggt ccgtatcaaa tactgattca catccagctc actctttttc 2134801 atacaggggc ctccttcaca ttaagtacct atattgttgc catttgctga ataaatcatg 2134861 ctaaaaagag aaccttcaat gaaaaatact ttacatttat attgcaatct aaaggtgtgt 2134921 ttgatagaat acaatttgtt ctattgtgaa gaagatttaa ccttaagaca ctgtgctaca 2134981 ggttgtatct taggaggtga aacacatgcc aaacattaaa tcagcgatta aacgtacaaa 2135041 aacaaacaac gaacgccgcg ttcataacgc gacaatcaaa tctgctatgc gtactgcaat 2135101 caaacaagtt gaagcttctg ttgccaacaa cgaagctgac aaagcgaaaa ctgctcttac 2135161 tgaagcagct aaacgtattg ataaagcagt gaaaacaggt cttgtacaca aaaataccgc 2135221 agctcgatac aaatcaagac tagcgaaaaa agtgaacgga ctttctgcat aatataaaaa 2135281 cgatcctcaa taatggggat cgtttttttc atttcttttt aacagctgta aaaggaacag 2135341 ttcgagcagg agctgcttgt cctttttccc ggttttcatc tcatagtcca tgacggcaag 2135401 ctgttcaata attaaacgga gctcctcctc tgaaaaaagc cttgcttgat ccatcgccag 2135461 ctttacccga aatgggtgaa cttttagatt agaagcgatt tgtttttgtc cgtatccctg 2135521 ttccgcgaag tacttcgtct gcagaatcag ccggaactga ttcgaaataa gcgccataat 2135581 tttgatcggt tcttcatttt gttttagcaa atcataaaaa atttgcagac tctctgttcg 2135641 ttttcggttg acgattttat tgatcagctc aaaaatattt tgttcaaggc ttctagcaac 2135701 aagcattttt acatcatcca gcgtaatttc ttcacgatct ccaataaacg tgcagagctt 2135761 ttgaatctcc tgaaaaatcg atgacagatg accgttcaca agcagaacca aatgctccgc 2135821 cgcttccgtg ccgattgttt tctgctctgt ttttgcaagg ttgacagtaa agtctgtcgt 2135881 ttcctttgca tttaattcct tcgcctccat cataaacgcg tgcttcttta acgctttcgt 2135941 cagctttttt cgctcatcaa gcttttcata cggagcaagc aggacaaaga ctgtgtaagg 2136001 cgcaggtgat tgtatatatg attcaagcgc actgacgttg tgctcaattt tttctttttt 2136061 cttttcacct gttaaaaaat atggattttt cacaatgaca agacgccgct cccccataaa 2136121 cggaaacgtt tcagcatctg caatcgcttg atccagcggg tcctcttcca gatcaaaaac 2136181 ggacagattg aaatcctttg tctcctgatc aacgaccgtc tgtctgatcc tgctgacggt 2136241 ttcttgcagc agatatgtct cttttccgta taaacaataa accggatgga cctctccttt 2136301 tttcaggctt ttccacacat caaataccat tgttgtacga cttcctctct ttcatcatcc 2136361 ccttctatcc taaattgagt ttgcaaaata gtaaagagga agcctgactg ctgcttcccc 2136421 atttatatta aacgcctgtt cgcaagcccc cgggacagct tgtaaaaagg cgataatcac 2136481 cagaacagaa aacgttacct tagcttctag atttttcaaa acaattccat tatacttaag 2136541 tcagtcagga gggataaagt tgaatgattt tgaaaaaaac gttcaaagca aacgaaatga 2136601 tgctgtagat tcagctgttg gttttgttgt gtccttcgga tttttcgcct tcttgtttgt 2136661 catggcaacg gttattcacc tagttggttc ataacagcga ctgcccgggc tgctgatttc 2136721 tcggcagtct tttttagttc gtctctgtta tatctgatgt atcatatgga ggatagacag 2136781 aaaaggttcc aactctgttt ttgtatctat attggatcgt tccgttttga tctgttcgca 2136841 gcacgcggat agaatgtctc tgtaatagtt gcagaacttt ttgatgagga tgatggtacc 2136901 gattgttttt cccggctgag ataatggccg ttttcggctg aagctgttgg atgaattctt 2136961 caccggtaga gcctttgctc ccatggtgcc ccacctttaa cacatctgct tttatattcg 2137021 gaaacacgtt catcacctct tgttcccctt ctttctccag atcacccgtc aagatccagc 2137081 tcataccgcc cgtctccatc cacagaacga gagatgaatt atttttgctt gccggatcag 2137141 gtgcttccgg tgacagtaca tggaactgca aatcctttat ttgcaacaca tcgcctcgct 2137201 tcacctcttc aattgccact ccctcttccc tggctgcctg cagcactttc tcatctttag 2137261 gttcagaaac gaaccctttc ggaatcacga ggcgctttac tttatgatgc ttcagcagaa 2137321 tctccgcctc tccgatatga tcttggtcag cgtgcgtcag aattaaagcg tcaagctgct 2137381 tgattccctt agcagttaaa aacggaatca gcaccttttc ccccagtgaa aacggatgct 2137441 gtttttcgcg ccaaggctct gacgagtaag acaaagtgcc gccggtatca attaagacac 2137501 gaccccgctg atgcggagca cctacaaaca tgctgtcacc ctgtccaata tctatcatat 2137561 ccacttctcc ttcggaacta agacacggat atataaagag cagaaacatc accgtgcagc 2137621 aaatgcctcc ggttaccatc aactgcgaca aggagcgttt ttcaatcgcc ataagcaata 2137681 ggatgatcgt gactgtgaat aaaaaaagca aaacaggtgc aggatgtgcg atcataatcg 2137741 tgaacacatc aacatctgca atgtttgtga ttaacctatt gatccagctt atcaataaat 2137801 caaaccagct gaaaaacaat ctcccaaacg aagcggaaag acttaataga agaacacctg 2137861 ctacagctcc cggcaaaata cagaaggtat aaaatggtac catcaacata ttcatcggta 2137921 cgctgatgat agaaaactga tgaaaatgat ataggagaat cggaagcgag cccagctgag 2137981 cgatgagtga tacaattgtc agctgcccca aggaggtttt aacctgctga aaaatagaag 2138041 aggatagaat taaagaaaaa ctgacggcga acgatagctg aaaaccggct tcaaagagat 2138101 gataaggatt gaagagcaga aggacgatgt acgaaaggca aattgcagtt gcagagcgga 2138161 cacgccattt gacaagactt ccagctaagt aaacacccga catgagagcg gcgcgtagca 2138221 ctgaaggagc agcgccggtc aacatcacat agagcggcag aaataacagc aacagaattg 2138281 acgccttttc tctagttata ccaaggcgga tcatgatata aaacaaacct gctgtcaaaa 2138341 tccccacgtg gagtcctgat attgccaaga gatggacaac accaagcttt tgatacgcgg 2138401 taagcacttc atcctccacg taaaatctgt caccaactgt aagtgcctgt acaatccctg 2138461 tcgaatcagg aggcagaagg ctgtttgtga atgatatgat atgttttctc aagctgagca 2138521 ccttgtactt gaaattttca ggttcgctgc agttttggat agacgtgaca gagtagttcc 2138581 aatgaatatg ctgccgataa agatactcgt tataatcaaa tgcacccggc acagttgcgt 2138641 gattcggttc ttccaatgta ccagtcaact cacatgacat tcctggttct atgtataaca 2138701 gctgttcttt ttcaccagca gactgaatgc gatacgcagc agcccatttt tccttatcag 2138761 gtgtctcaac catcatagac atacggtcgc cgtcaatttt gggaatagtg tcaatcactg 2138821 ccttgaattg ataggttccc tgccgatagg aagagacatt ctgagaatct gtgactgcat 2138881 acagtacaaa aaacaatata aaagagaaga aacaaacaat aataagaaaa gcgtgcctcg 2138941 ttttgattaa aatgatgagg agaaagagga tgaaaagaaa aatagcgggg aaataagcgg 2139001 cggcagtaat tccagccgtt gccgaagctg ccgccatagg caataataag cgcgaattac 2139061 gcattcatca cacgtagctc gtgaaaagtg tattcgcctg ttcatgtatc tttttcaatt 2139121 cttcctccgc taaaccggca tcagccaatt tccctattag acccgctaca aatgaaagct 2139181 tttctctgtt tttcagatca acgatcattt catcgagttc aacctgttca acagttacac 2139241 ccgcctgttc aaataattcc tgcgcatacg gatgtgtttt gtaatcctca gcataataaa 2139301 ccgttttgat accagcttga ataatagatt tgcagcattg aatgcacgga taatgcgtca 2139361 cataaatctc ggctccatca gtcggcaccc caaacttaga gcattgaaga atcgcattca 2139421 tttcagcgtg aatggttctt gcgcaatgat catctatcat taagcatcct tcatctgcac 2139481 aatgtacgcc gcccgcgatt gacccattgt agcctcctgc tatcatgcgt ttgtctctga 2139541 ctatagtagc gccgacagat aatctcggac atgtgctgcg cagcgccaat aaatggcttt 2139601 gagccataaa gtattgattc catgaaattc gttccacgtt gttccctcca aatgttgtgt 2139661 tgcctgacct ttagtttacc tatcataatg catgaccgtc aaatcacttt actgtaatgg 2139721 aagactttat tttctcaaat gacttttcac ctattcctga aaccttagtg atatcttcaa 2139781 ttgtttggaa acgaccgttt tcctcccggt atgcaataat agcttcagct ttggatggcc 2139841 ccacccctga gatgccttgt aactcctcta aggttgctgt attgatattc accagcgctc 2139901 ccttccctcc atcgctttgg acagaccctc cgccaccttg ctgcactgct gtttcctctc 2139961 cctttttcgg gatgtacacc actgtcccgt cctgcagaat ctccgccaaa tttacttgcg 2140021 cttcgtctgc ttgttcactg gtcccgcccg ctttctcaat tgcctgagat actctgtccc 2140081 ctgttcgcat ttcataaacg ccaggatgct gaacagcacc tttgatgtct atcacaattg 2140141 tttcgtttga ctcgtcgttg tttgcttcct gctttaccac tgtattttct gtctctgttg 2140201 gtacagcttg cttcaccggc tctttatttt tccctgtggc cagaaagatc ataatcgctg 2140261 tgaaaacagc cgcagaagcc gctaaaataa ttgctttctt atgctgattc aaccaattca 2140321 tcgtgcatgt tccccgcttt cgtcatattt tattttcata acacatatgg tttagaggat 2140381 aatagctcaa aggaggggaa accattgaag ataggcttta tcggcacagg aaatatgggt 2140441 acgatcctta tcgaatcatt tattgaatca aaagcggccg atccctcaaa catgacaatc 2140501 acaaaccgca caattgaaaa agcgttgcac ataaaaaacc gctacaacag cataaacgtt 2140561 accgaaagtc tcgaaaagct cgtttctgaa aacgagatga tttttatttg tgttaagccg 2140621 cttgatatat atcctttact ggcaagagcg ttaccttatt taagaaaaga tcatattctc 2140681 atttcaatta caagccccgt tcaaaccgaa cagctcgaac aatatgtgcc gtgtcaagtg 2140741 gcgcgagtga tcccaagtat tacgaacaga gcgctggcag gtgtttctct cgtcactttc 2140801 ggcacaagct gcggcgaatc tgcaaaagcg aaaatcaatg agctgatgca gcatatctct 2140861 catccgctgc aaattgaaag tgacatcacg agggttgcat cagacatcgt aagctgcggc 2140921 cccgctttta tgagctatct gattcagcgg tttatagatg cagctgtttc ggaaacatca 2140981 gtgtctaaac aggacgcgat tttgatgtgt aaggaaatgc ttgtcggaat gggaaaactg 2141041 ttagaaaccg aattgtatac cctgcctgca ttacaggaaa aggtttgcgt taaaggcggt 2141101 gtaacaggag aaggcattaa agcgctggaa agcggtgtgc aggatatgtt tcaccgggta 2141161 tttcaaaata ctcatatgaa gtacgaggag gatatttccg cagtgaaaaa gcagtttcat 2141221 gtgtagacga gtatgtcata cgttcgtctg tactgcaaaa gcataaaaaa gcattttaaa 2141281 aaaccatcgt tttaggaaac gatggttttt gatttctgcg ccttgaaaaa gaggcgttct 2141341 gattgtgctg atggctcggt atccgtaaaa tcagctgtca cgcgatggag ctgaaagccg 2141401 cagttcttaa gcatttcttc gtattcttcc accgggaacg ttctttgctc gtgtgtctca 2141461 tcaaaacgat catacgcttc tccgttccac acaaaaaacg acatatcatg aatgacagaa 2141521 agctcgtcac ttccggcaaa gctctgccaa atatagctga tatcttcgtc ctggtcagca 2141581 aatgtgctat ccggaaagac ttccgcaatt ttaaaagatg aatgaacatc aaacagcagg 2141641 atgccttcag gctttaatac ccgaaaaaca cttttaaagg tttcgatcac atcatttttt 2141701 gtttttaaat aatttaatga gtcacagcat atcacaacag cgtcaaattg accgtcaaag 2141761 ccggtaatct ctctcatatc ctgctgaaga aataaaatag gctggctact cgataccttt 2141821 tgctgggcga aagaaagcat ctcttcgctg agatcgatgc ctgtaacctc gaagcctttt 2141881 tcggcaagcc ggatggagat ttcccccgtg ccgcatgcca gatcgagaat acggcctttt 2141941 tccgggagag atgcttcaat ccattttgtc cattgatcgt aaggcgcgtg tgacattagc 2142001 tcgtcataca cgcttgcaaa gccttgataa atcattgatt cattccaaag tcaagatctg 2142061 cgagcggagc gtctccccac agcttttcaa ggttgtagta gcttctttca tccttgtgga 2142121 agacatggac aactacatcg cctagatcaa cgagaaccca tcttgcttca tcaaagcctt 2142181 ccatcttttt gacttgaatg ccgttttcat cagcttgatc cttgatttca cgggcaatcg 2142241 cctgtacctg tttatctgaa tttccgtggc agatcagaaa ataatcagca accagagaaa 2142301 taccttccat atccagtgct aaaatatcct ctgcccgttt atcatcgcaa gccgcagctg 2142361 cgatctttaa aatggacttt tggttcattc acaaattcct cctgttcagc tgccagacac 2142421 aagccagtta tacgttaaaa atgtgtctgg aaaaaccggt tgattttttt tcataagaaa 2142481 aaccattgta tttttaatgg actgaatcag cgcttgattc aaatctgtct cagcaagctt 2142541 acgcacctca tcgacaccgg gaaatgcccg gtttggctca atgtaatcgg caacgtaaat 2142601 gactttttct aaaagtgtca tgccggggcg gcctgaggta tgatacctaa tggcgtcaag 2142661 aatgtcttca tcttgaaccc ctgcctctct ttggaccaaa taagcgccga ccggagcgtg 2142721 ccagagctcc ggattatgat ccaataaatg cgcaggcatt ttttcacgcg caataatttg 2142781 tttcatttct tctttcgggc ggaatttggc gtaatcatga aagattgccg ctatttccgc 2142841 ttttttagaa tcggctccaa aacgctccgc aagttcgatc gccgtgttca tcacgccaac 2142901 cgtatggata tatcggtgtt cggtcaattg ctgcttcacg catgcaagtg cctcctcacg 2142961 attcatataa accattctcc tctacatact tcttcacttt atcagggatt aagtagtcag 2143021 tgggcttctt gcttttaaac cgttccctta tcatagttga tgatacctca aattccggaa 2143081 cgtctgcaaa gagaagcgga taaggggttt caacatgaaa accggggcgc tttactccaa 2143141 taaattgaat gaggttcagc agctcgtcca gcttatacca tttcggcaaa tattcaatca 2143201 tatcagcgcc gataataaag aacagctgat catttggata acgctgcttc agtaaagaaa 2143261 cggtatcaaa ggtatatgat ggcccttctc tttccatttc aacaagctcc agcttaaagg 2143321 acggattaga ttgaattgca agctttagca tttccacgcg atgaaagctg tcggtatagt 2143381 cttcgttctg tttatgcggc ggaatttgat taggcataaa ccaaatttca tcaagccccg 2143441 cctggtacag cacctcattc gccattaaga ggtgaccatt atgcggaggg tcaaacgtgc 2143501 ctccgaaaat tccgattttc ttcatttcaa ccacctttaa ggaagctcga tttgtttatt 2143561 ttcctttgat tccttatata acacaatcgt attgccgatt gtctgcacca attgagagcg 2143621 gcttcctttt acaagagctt ccgctacatc gtttttatcc tcttcgcaat tctgaagcac 2143681 gctgacttta atcagctctc tcgcttcaag cgcctcagca atttgtttaa tcatgttgtc 2143741 gtttactccg cctttaccta cttgaaaaat cggcgttaaa tgatgcgctt ttgaacgcaa 2143801 aaaacgtttt tgtttacctg ttaacattct gttcctccta attttcctat tacaatagat 2143861 ctcatttttt caatattagg ctcttgtcca gtccacaatt ggaaagacaa tgctgcctgt 2143921 tcaacaaaca tgcccacacc atcgagtgtt ttcaagcctt tttggcttgc ttcttttaaa 2143981 agtgccgtct gtattggatt atacacgata tcacatacga cggcactgct cgcggcacgc 2144041 tgtaatgaaa gcggcacatc gtccacgttc ggatacatgc ccacagacgt tgtatggatg 2144101 ataacatcat actgctcaag acgttcttct gcttctttta tgcttaatac ttctttattg 2144161 tgaaacgagg gagtagcttc tgtaagccgc tttgcttttt ctaacgtccg gttgcaaatg 2144221 tcaaattttt tcggggtatt tcggacaatt gttgtaaaaa tggctctcgc cgctccgcca 2144281 gcgccgatca ttaagaatga cagttcagag atgggcttgt ctaatacctt cattaatgac 2144341 ttcacgaagc cttccccatc ggtattgtat ccgacaagct tatctccctc tcttctgacc 2144401 gtgtttacgg caccgagcac ttttgcactc tcatcaatat gatccaaata atccataatg 2144461 gaaaccttgt gcggaacagt cacattgatt ccttgtacgc ctagagctct tattcctttt 2144521 accgcatcct ccagatcatt ctcttctacc ttgaaggcat gataatgtcc gtcaagcccg 2144581 aggtctttca atgatgcgtt atgaatatca ggtgacatag aatggccaat aggatttccg 2144641 ataaccccgt acagcttttt catacacctc tccccttttc ttaaattaat gaacgccgaa 2144701 caaatacatg aacgcctttt ggcgcgtatg cagttacctt tttatcagcg tcatggacag 2144761 taacccagcc taacccagag aaaacgatat ctgtcttttt gtcttttatc gtaaacgtat 2144821 gggcgaccaa ttcaggaaac tcatccattt catctttacc cggaggtgtg agcaattccc 2144881 ctgcatgctt ttcataaagc gcgtctgcat tttcaagttt tgttctatga atcatcagct 2144941 cattcggcat atagcaaata aaaggagatc tttccccaga cacataatca aaccttgcaa 2145001 gtccgccaaa atacagtgtt tgctgatcat taagctggaa tgtgcgaggc ttcagctcct 2145061 ttttaggaga taatattttc aggtcctttt tattgacata atgcgccatt tgatggttgt 2145121 tgataattcc cggtgtatca taaagcgatg aaccgtcatc cagcgggatt tcaatcgcat 2145181 caagggttgt gccaggaaat tgggatgttg taataatatc ttcttcacct gacacttctt 2145241 taataatccg gttaataaag gttgactttc ctacatttgt acatccgaca acatagacgt 2145301 cttttccgtt gcggtaatgc tcaatcgcgt caattacttc tctgattccc tggccgcgac 2145361 ccgcactgac caaaaatacg tcaaccggtt ttaagccaag ctctttcgct tcacgcttca 2145421 tccattggat cagacgctct cttttcagtg acttaggcaa aatatccgct ttattgccaa 2145481 ctaataagat agggtttccc cccaccaagc gctgcagccc attaatccag ctgccgttaa 2145541 aatcaaaaat atcaacaatt tttacgacca gagagtccgt ttctccaata ccgtgaagaa 2145601 tgttcaaaaa atcatcatca gttaaggaga catcttgtat ttcattatag tttttcagtc 2145661 tgaagcaacg ctggcaaatc acattttctt tcgtaagcga tgcaggcggc gcgtacccca 2145721 aacctgtttt gtcctcggtt tggatcgtaa ctccgcaccc gatacaaaca accttttcca 2145781 tttcttactc ctcccactga atgtgccctt ttcgtttgag agcactcagt attctgcgtt 2145841 cgacctggcg gttaaagcgc gtaatgaatc cgtcagagga agcgactggc acgaccaaaa 2145901 tcgtatggta gccgtttcgg tttcccccga gtacatcggt cagcagctgg tctccgatga 2145961 caacgcagtc ctcttttttc agctccatat tgcgcaccgc tctattaaag gctttaccca 2146021 tcggttttct tgctttatag atgaatggga ttccaagcgg ttctgagaaa agtttcactc 2146081 ttctttcgtt attattagag acaattgtca ctttaatgcc gtgttccttc atttcttcaa 2146141 accactcgat caatcgcggc gtcgcgttcg gcctgtccca ttcaacaagc gtattatcca 2146201 ggtcagtaat aattcctttt acatttcgtt cctttaattt ctcaggtgta atatgaaaaa 2146261 tattttttac aaactcgtca ggtaaaaaaa acttttttaa caaaacccgc acccttccct 2146321 ttttctttct ttcaaaatga ttgtcgaaaa aaatcgaact tgcgcctaaa gaaaaactga 2146381 gcaaaaaaat ttcgacaaaa attgggtttc ttcaccaggt gtggataaat ttacacacac 2146441 tatccactct tattacatca ctctttagac aaattataaa cacgatactc acaagttatc 2146501 cactttttgg tgtggataac agaacgattg ttcttatatg catttcatgg tagattaaag 2146561 ataacttcaa cctcagatga atgcaactta tcattgtatg cgttaaaatc atgaatgatt 2146621 ccaactttta aggaggtgcc tctcccatta attgggttcc tagcatgaga aaactgtctg 2146681 atgaattact aatagaatct tatttcaaag ccaccgaaat gaatttaaac cgtgacttta 2146741 ttgagttaat tgaaaacgaa ataaaaagaa gatcgctcgg acatattatt tccgtatctt 2146801 cttaatagga atttgtctat tttttccggg cgtatttcct ttttttactc agatgactga 2146861 tattatatca ctttggctgc gcgctttact actattttca gcaaaaaaca cccctaaaaa 2146921 gaggtgtttt aaagggccgg ttattatgct aaccagtata tgccgcccac aacaaggaga 2146981 acaacaacta aaacaacaat aaaagcgtat ccatatgctc tgcctgcgcc atacatgtga 2147041 agcgcctcct taataaggtt ttataacagc ctatgtagga gaaataaatc ggactaggcg 2147101 gttgtccggc tcaacgctgc aggatctgcc ccgcgaacta atttattaat gttcaacaac 2147161 agaatttcgt ctattggcaa taaagaatcc acaaatcatt gcaagaatgg ccatcgccca 2147221 ccagaacgtt gagatcgcct gatcatgatc gatgataatc aaacgaatga cagctgtgat 2147281 gccaatataa atgaagtagc gaagcggaaa atgaaagtct gatttgaagt atttgataat 2147341 caaagcaatg aactcaaagt acatgaagaa tataagcagt tctccaagca tctcataata 2147401 gctgtccact ttgttgaaca gtgacttgta tacgaatagc acaatgtacc aagtctcgct 2147461 gatcagaagt gcgcttaagg ctaacgccag aaagaacaga cagacgttga gaagcgcttg 2147521 taacaggtaa ggcacctttt tgaatttgtt agaaaatctc atcatgttgt ctcctatttc 2147581 aatatattcg tggtttttat tctcagccta catcttggtg ttccaaaatc gtagcacaat 2147641 gtagtactta gaattctttt gtatactgtg aaactgtccc tgcatgcggg acatcattcg 2147701 cgcaatgctt ctttcaccga gtccgttgct ttccggtgtt atatctgcaa gtttaatcgt 2147761 attgctaaca tggatctcaa atatctcttg atccgataca aacgtgatac tgattttttc 2147821 ttccggatct gcgtatttca ataagtttga catcacatta tcaaatacac gaccaagctc 2147881 ctccaaattc acgttaatat aggtttccgg cagctcgcct gaaatatgga cccgaaaatg 2147941 ctcctgatga aggatagcaa tctgatctga tattagatcg tagatcactt ctttcactgc 2148001 aacggtctcc agatcggcct catattcctt gttcagcagg aaatacgcaa acagattgtc 2148061 agacaagctt tttaattgca gtgctttacc ataagcattg gctacatacc gatctttgct 2148121 ggcacccgct tcgcctccct cttttttggc aaactccaga ttcatgatca gcgacgtcag 2148181 cggtgtgcgc atatcgtgcg acatttcggt aaccaggctg cggctctcag cttgcaattc 2148241 ctcgatagct ttaagtttat ccaggaaagc tttccgcaga tcctcaatgc tctttgcaat 2148301 catcgctaat tcatcatgcc cttttatcgt catctcgtag tccagttcgc ccccttcaag 2148361 aatatgaatc tcttgatgaa tcgttttaag gtagcgaaga ctttggcgaa ttccgaagag 2148421 aacaatgatt aaaaagatga gggttgcccc gagcaaatcc aatgcaaagg ccagatcata 2148481 atatcgggaa gagtagaaac cgtcgataat gactcgtcct tcaccatcgc taaacttgac 2148541 aggatgtgaa tgattttgag cgtactgagt cagcttttcc tttccataat ccgattcgga 2148601 ataaatagaa tcatattgca gctcctgatc cttgaatatg gtgaggttaa tgtaattttc 2148661 ttttttgacc cactcgccaa acgcttttct atctgatgta gacaactcat tttctgaaac 2148721 gtacttgctg aatttttgaa tgtatcttgc tgactcctcg tgataatact cttccgaact 2148781 cagatatccc tcgatcagat catctgtgat cttttgcaac gtcagaaaga tcacaccact 2148841 cacaatcgca gcaaccatta tcagcaaagc cagttttttg gttagcgtaa atttaagatg 2148901 cgccaaatcg atatcctctt ccccattcag tttttatata aaccggacgt gccggatcat 2148961 cctcaatttt ggagcgcagc ttccgtatat gcaccatcac cgtattgttg gaacagtaaa 2149021 agtaaggctg tccccacaca ctctcatata tattttgggc agaaaatatt ttgttgcgtt 2149081 tgttcatcag aagtttcagg atacgatact ccagatctga caacttgatt tgcttctcct 2149141 ctttccacac ctcattaaat tcttcgctca ctcttagttt gcccccgata agaaatgttt 2149201 cttcctgttc cttcttttcc tgatagatag tatatctgcg taattgagca atcactctag 2149261 cgtgaagttc ctcttccgag aatggtttag tcatataatc atcgccgccg gcgagtaatc 2149321 cctcagtttt atcgagtgta ctcgatctgg ccgtcagaaa cagaatcggg acgttagagg 2149381 atttcctgat gtgctgacat gtttcaattc ccgaaatgcc tggcatcata atatccaaaa 2149441 taaccaaatc aagcgagtca ttcacaagtt gcaatgctcg ctttccatcc ttggctctta 2149501 gcacctcgta acctgcacgt gtaagggatt cctccaaaag atcaccaata tcctcatcat 2149561 cctctacgac taatattcga taggccatgt ctctctcacc tcatgattct tgttgttatt 2149621 tctcgtgtgt ccttactata tatcgttcat agtaataagt acgttataag atactacgta 2149681 aatcttaaca atttatgaaa gctgatgctc gccacaaatt tgtcacattt tctaaaaaaa 2149741 atgatgactc ttcataaatt gttaagattc ggtctttata tttatccatt gtaaggctca 2149801 agtttttcag atccgcacta cacattgccg tgataaatgg gaaaggagta ttgatatgat 2149861 tgtacaaaaa gaaggacgcg ggcaaccggt gagtctgcgg gaacgggttc attttctgga 2149921 catcgtacga ggatttgcct tgcttggcat tattattgtc aattattttc tgatcgtaga 2149981 ttcagtaaag ggattcgaaa tggcctccga tgacgtactg cataagctgg tttcctggtt 2150041 tgccgaaggg aaattcgtta cgttattctc cttcctgttc ggagtcgggt ttatgatctt 2150101 tatggatcga gccgcgcaga aggtagagag tcccaacaag ctgtttgccc gcaggttatc 2150161 tatcctgttg ggatttggca ttttgcacat cacatttgtt tgggtcggtg acatattggc 2150221 cttttacgcc gtaagtggct tcctgttact cgccttctat aaacgcacgg ccaaaacggt 2150281 gcttagatgg attatcgcac ttatcgtgtt tcaattcctg actcctgttt tcacaatgtt 2150341 gtacaatgtc atcaatactg cagggtcaaa aaacccgaat ttttcagagt ttactttgtt 2150401 tagccacagc agccttacct acatggaatc catcagcact cggtggacag atatggtcac 2150461 gatggctgcc ggctctttct ctatgatcta ttccatgttt ctcatgtttc tgctgggcgt 2150521 gtactttgtt aagatggaat ttttcaaaga catggaagcg aaaaagccta tatggaagcg 2150581 tatctggatc attagcacaa tcgcttttct aataacacaa agcagtatat tactagacat 2150641 gtttaatctt tctgagaata tgctgtggaa ggacatttcc tctgtcttgg gtcaaaatgg 2150701 cggcttaacc ggaagtatgt tttatatgag cacttttgca atgctgtttc tataccttcc 2150761 tcagctgcga ggccctatga tgatattcac caaagtcgga cggatgtcat tgacctgtta 2150821 tctgcttcac tctatcattg gaacagttct gttcctcagg tacggattcg ggcttgcgga 2150881 tcatattcaa tccgccggca cgttcatgtt cagtctggcc gtgtacttcg ttcttatgag 2150941 ctttagtaca ttgtggttga aacggtttag gtacggtccg atggaattag tatggcgcaa 2151001 gctgacgtac ggcaaagtaa acgggagtcc caaagcaact ccgctgcatt cggaaaaatc 2151061 tattcagaaa taaccccctt gcacagattg catgacttca aattagtgtt gttgaatgaa 2151121 gcgggcatta aacggacaga tttgatatat ggactagtta tttttatatc atttaggctt 2151181 ctttgggcta ataaatccac cagagtttac tcaatgtgca ttgctcatga tcgaatctaa 2151241 attgaatctt ttacgcatgt tcatagtcaa aggcgcctca ttcgactatt tttgtaactt 2151301 ttcgcaggaa aaattcgaga atgatgacaa atcccgcata cgacacttaa tacggtagtg 2151361 aacaatagta aattagggtt acatgcagct tgttttccaa tgaaacaaag aaaaagaatc 2151421 atacaaaaag acaggagaaa gcttttgaag tattttaacg ccaaatttac cgcggaagaa 2151481 agagcgatgg aatcactttt ttgtgaaaag gcctcgcaga gcagctcgaa tgttttactg 2151541 aacgactgaa ctctatattt tagcaactga gggagtgaac aatcatgaaa actaaaaatg 2151601 aaccaaaagt tattctggaa ctagcaaagg aatctgatct gccagaattc caaaaaaaat 2151661 tacaagaagc ctttgcgatc gccgtgattg aaacgttcgg tgattgcgaa gatgggccga 2151721 ttccatcgga caatgatgtt caggagtctt tcaatgctcc cggagcagtg gtatatcata 2151781 ttcttcagga tggtaagaat gtcggtggtg cagtagtacg tatcaacagc caaacaaatc 2151841 ataattcgct agatttattc tatgtatctc cagaatatca cagccaaggg attggtcttt 2151901 ctgcttggaa agccattgaa gcacagtatc cggatactgt gctttgggaa accgtgacac 2151961 cttatttcga aaagcgaaat atcaacttct atgtgaataa gtgtggattt catatcgtag 2152021 agttctacaa tgaacatcac tctaatccgc atatgcatcg caatggacgt gaagatgaca 2152081 agcccctact gaatgatgat gactttttca gatttgtaaa gattatgaaa aaaaaggact 2152141 aaacaattga acacggcgag atgccgcaga gagttgctgg taactttttt atatttcatt 2152201 atcagaggaa ggtaataatg atgtttaaaa ggtgttttga tccctgtctc ataaacaggg 2152261 gtcaaaacac ctttgaatca tcggtttctt ttctgacata taccacgccc actagtccct 2152321 caacatagta aaaacatatc atgagttaca aaagctttta ttcaaagcat atgtttattt 2152381 tatttatact tattttcatc atttttcaga attctggaca caaatcgggt acctattaga 2152441 ggccaaggaa ctctacattt cattaagaaa tacgtactca ttgccctgct ttaattaatt 2152501 ttaagccctc gcactatgcc cccccctgaa ttaagtattt gatgtaactt tgaaattaag 2152561 tttatgaaaa tctgtcacaa acccttattt cataacacat catttgtttc agcttccctc 2152621 gcgaataccg gattaatgct cggctttaag atagtcaacc aatctctccg cactgttctt 2152681 aacatcttct tttgaaagat gaagtgtccc atattgtgta aacgcaggaa gaaaacgcat 2152741 tcctatatag ttagcagtga cttgaaacgg tctgataagc tcgctgatcg tgatattata 2152801 ttctccgcct gcttgataat cagattcctg tgcgcctaag gagatagcta agagtagttc 2152861 ttttccatgc aatttagttc ctccagttcc ataagcccag ccatgtgtta acacatcatc 2152921 ttcccattgt ttgagtaacg cgggactgct gtaccaatac attgggaact gaaaaacgat 2152981 acgctcatga tctaacagga gctgctgctc tttttctaca tcaatgataa aattagggta 2153041 ttcaccgtac aggtcatgaa ccgtaatgtc tttctcttgc tttaaacgat tcatccaggt 2153101 tttgttgaca acagacgttt ccaaattagg atgtataacg ataactaatg ttttcattag 2153161 actgattatc ctttctttgc caattagtta ttatttttta cgataatgaa ttgattctaa 2153221 ttttaaaata gcaactttat ttacacctat tttatccttt ttcatgaatt cagggcaact 2153281 aattgggcac caaaatcaat gatgacttaa gacattgttt tgtagaaatc cgatatacag 2153341 aataatccat tatttagaaa atttctacct tttccctcaa tccgagctcg ctcttcatgc 2153401 ggatggccta ttttaaagga ataactgact atgttcatca gttattcctt taaaatacga 2153461 aagtctacga tatttccata tcgatccgct tcaatgtgac agcacccctc aagcagctgt 2153521 tttaattttc cacgtccgcg ttgtaccctt gattttgctc cggagtaaga aatgccgagc 2153581 ttttcactca actctttttg tgataacccc tggaaatcag ttaactcgag cgcctctcga 2153641 tacttttcag gcaaccgttt gatggtcgat cgaatacaca cagttgcttc cttggtgaaa 2153701 ttttcttcct ctgcactgtc attaaaatgt agaacatcag gcaatatttc gcttgttttt 2153761 tttgtacggt aaaaatcaat aatcgtattt ctagtgatcc gataaatcca gctgtcgatc 2153821 ttttgttcat cgatcagatt tgggagatgc acttgtattt tcataaatac gatttgcaag 2153881 aggtcatcaa cgatagattg atcgttaacc ctatgtgaaa tatatgtttt taacggctga 2153941 tgaaattgat cccatagatc ctctatattc atttgaaaaa acctcctata attttgcgtc 2154001 tgctttacat ttgcttcgtc tttttaatcg taacaaagag caaacaattg ttgaatcaat 2154061 tgtattgcag ctgttgccaa aaataatgat aaaggagagg tttgttgtgg agtataccta 2154121 tttagggaga acaggattgc gggtgagccg tttatgttta ggcacgatga attttggagt 2154181 tgatacagac gaaaagactg cgttccgtat catggatgaa gcacttgata acggcattca 2154241 attttttgat actgccaata tttacggctg gggcaaaaac gcaggattga cagagagcat 2154301 cattggaaaa tggtttgcac aaggaggaca gcgccgcgag aaagttgttc tggcgacaaa 2154361 agtatatgaa ccgatttctg atccgaatga cggaccaaat gatatgaggg gcttgtctct 2154421 atacaaaatc agacgtcatc tggaaggatc actgaagcgg cttcagacag atcatatcga 2154481 attgtaccaa atgcatcata tcgataggcg gacaccgtgg gatgagatat gggaagcttt 2154541 tgagactcag gttcgctccg gcaaagtaga ctatattgga tccagtaatt ttgcaggctg 2154601 gcatttagtt aaagcgcaag ctgaagctga aaaacggcga ttcatgggac tcgtcactga 2154661 acagcataag tatagtttat tagaacgaac agctgaaatg gaagtgctgc cggctgcacg 2154721 ggatcttggt ttaggagtag tggcgtggag tccccttgca ggagggcttc ttggcgggaa 2154781 ggcattgaaa agcaatgccg gaactcgtac agcaaaaaga gcagatttaa ttgaaaaaca 2154841 tcgtttgcaa ctcgagaaat tttcagattt atgcaaagaa ctaggagaaa aagaagcaaa 2154901 tgtggctttg gcatgggtgc tggcaaatcc agttttaact gcgccgatca tcggaccacg 2154961 aacggttgag cagctgcgtg atacgataaa agccgttgaa atcagtctgg ataaggagat 2155021 tctccgcatg ttaaatgata tctttcccgg acctggagga gagacacctg aggcatacgc 2155081 ctggtgatac attcattact caatactgac atttttctta aatatttata ctgaactatc 2155141 atattaagaa agacaagagc atgtttgtct cttgtctttt ccacatcgtg ctgaaaatgc 2155201 tggctaaaca tcgacaaaaa tgctgccgct taaaaaagaa ccctaaacaa tagagtaact 2155261 ggaaagacaa ctggcttgat cagcttggga cccctttcag ctgtatttaa atcaatcaaa 2155321 ctaatgattc attggcagtc taaatattat tattgtttct ttacaaaata gtaatagccc 2155381 ctgtaatgat tgctaacaac gtaataacta atgatgtaat tacagcccac ttaacggcaa 2155441 acctttgaaa tgaccccaag tccattttaa gcatgcttac tagcaatact gttgacgcaa 2155501 ccaatggact catcagatga accggctgcc ccattataga agcccttgca atttctactg 2155561 gttctatacc atatgctgag gcagcttctg caaagatagg taccatacca aagtaatatg 2155621 catcatttga taaaacaaaa gtaaacggaa tactagtgag tgctacaata acggggaaaa 2155681 accctcccat tgatgagggg atgatggata ttaatgatcc tgctatggca tccaccatct 2155741 ttgtcccgga taatatacca gcaaatactc ctgctgaaaa taccaataat accacggtta 2155801 tggcattacc agaatgctcg gcgattcgct ccttctgcat ttttacattc ggataattta 2155861 tagtaagggc aagaacaaaa ccaattaaaa ataaaactga cggatgctta gttccaagca 2155921 caataaacac catgatactt ataacgagga ataaattaag atatattaag cgtggccttt 2155981 tcaattgttc gctctccaaa gtagcagcca tataagattg agagctgtcc tttgttatat 2156041 gtctaggctc taattgaacg atgcctattc gattcctctc tttccttccc attagaaaag 2156101 ccagaaatat cacacaagca atacctccaa gcatggtcgg aagtaatggc acaaagaaat 2156161 ctgaaggatc caaacccagc actgaaatcg ctcttgtagc tggtccgccc catggagtca 2156221 ttccgctaac gatactcaac gacagcattg ctaatgtcgc cataaccatg ggattcatac 2156281 caattctttt atacaaaggt aacattgctg agactgttat catataggtt gttgtaccgt 2156341 ccccatctaa agcgataagc attgccaaga cggcagaccc tatcgctatt ttcacagggt 2156401 ctccctttac tatagataaa attttttcta ttagcggatc aaataaacct gcatcaatta 2156461 aaattccgaa aaaaagaata gcaaacaata gcaatgccgc tgaacttgca actgtttgaa 2156521 ttccttctaa aatcatgtcg ccaataccct taccaaaacc tccaataaga gcaaaaacaa 2156581 tgggagtgat ggtcaaggca acaataggcg agactttctt tgtcattatt aatattgtaa 2156641 aaacagttac catcgaaaaa cctaaaatag taagcatatt acacctccaa gaatgcgctt 2156701 tcaaatgact tttgattaac atatcttata cggtgtaata agttaaataa atattttttt 2156761 actgtgtttc aaaaaaaatt ctatcataac tttaaatggt taccatttgt tcacccttta 2156821 aaaaatcaat gaatgcttta acgagtttga ttcctaatga tttttgatcg tacattagcc 2156881 aagtatctct cattagaggc ttacccttag cattatacag ttccattgtg tacaaatgat 2156941 cagattcctg caggcaaatt tctggtgcta tggagtaacc aagaccatgc tttaccatct 2157001 ctttgcaagt ctcttgtcga tccacttcca ttgcaataat gggggcttgt tttagattcg 2157061 tatgcatcca atcttctata atcgttttta aagaagcatc cgttttatat ttgataaaag 2157121 gtaaaaaagg aagttgctct atcgttattg gtttttttga gatgatatgt aatttttccc 2157181 gtgtcagccg ttcctccacc cctttccagc gatggcttcc tctcagtata ccgacttgta 2157241 caataccagc atctaataat ttcatgacat ctgtgctcca gcctgtttgt acactatatt 2157301 ggacattagg atacatagtg gaaaattccc ttaataactt agggagctta tattgagcga 2157361 aattgcttga tacccccagc cttagatgtc cttgcacctc tttgcttaga ttagagatat 2157421 gatctttggt atcttgaagt tcctgtagca ttcttcttgc ataagcaacc aagtgttctc 2157481 cttccgcagt aaaggtaatt cctttatgcc ttttggtgaa taattcaatt ccgaaaatct 2157541 cctcaatctt tttcaaccga taagtgatgg aaggctgtga tgtaaataat cgttctgctg 2157601 tttttgttac actttgttct tcgtgaagaa ttttcaataa aatccaatct ttctcatcca 2157661 ttttcatctt cctttctagt ccttctttca caattataaa agttttttta tcgaatatta 2157721 agaaaactta tattttattt ttattttttt accttctaca ctaaaaaaca taaaaaatac 2157781 tacctttaag atgaggatga tgacgatggt caagacgaat gtaacaatca tgagaggcgg 2157841 aacaagcaaa ggcgtttttt tccacgaatc agccatgcct aacaataaaa acgaatggga 2157901 gccctttttg cttgatgtca tgggaagtcc tgataaaaga caaatagatg gtttgggtgg 2157961 cggtaattcc cttactagta aagtggcaat aataaagaaa gcatatactt cggatattga 2158021 tgttcactat actttcggtc aagtcagcat ttcggaagaa aaggtggact ttaaggggaa 2158081 ctgcggaaat atctccgctg ctgttggtcc atttgctatt gaagaaggac ttgtaaaagc 2158141 gaaagaacca atgactgcgg taaggatcct gaataccaat acgaataaaa tgatcattgc 2158201 ggaagtagaa gtggaagacg gtcaggtcaa atatgacgga gatgttacga tatctggagt 2158261 acctggatct ggatctccaa tctatttaaa ctttcatgat gccgctggtt cagttaccgg 2158321 tcatttattg cctactggaa atagttcgga gtttttagat acaagtcaag gccaaataga 2158381 ggtgtctatt atcgactatg caaatccatt agtttttgtg gaagcgagca gtatcggcct 2158441 ggatggaacg gaacttgcag aagaatttac tgatctacag ttggctcaat ttgaagaatt 2158501 aagatccatt gcggcagaga aatgcggctt tgccagtcga ttttcagcta caaagttatc 2158561 gccggctgtc cccaaactgg ctatagtagc aaaaccagag aaatataaag atagtacagg 2158621 tgcttggcat tcaagcgttg agatggactt acacatcagg atgatgtcca tgcaaaagcc 2158681 acatcaagca ctggctgtca ctggagcgat atgtacaaca agagcccttt cagtggaagg 2158741 tgcaatccct gcaagaatag caaaaaacca ctctacaaag gttcggctag ctcattcttc 2158801 tggtattatt gaaacaatgg tggagcccac tggtataaag atcgtccgta ccgcacgacg 2158861 tattatggac ggaacagttt atacgcatgg agactatcaa atgatgtaga tggactgtgc 2158921 aaaaagcctc ccccctttcc atcgttaata gatggattga atgcgccttc ttgcacagat 2158981 ccattgtaat cttgcatggc tttaaaaaag cctctatatt gttttttatg aaatcgccaa 2159041 ggtcctttca tgtatctgcc tcaagcatga cataatcatt atagagaaaa ttgaatactt 2159101 tttactgcaa ataaaaagat accaacatca ttggtatctt ttagattgag ttcatctgca 2159161 gcggtttctt ttcctcactg cttatttgat tacaaaatta ccgtactcgt ttgaacgaac 2159221 atgaatcggt ccgtttagat tatagttgtt ctccttggcg atagagcgaa gcacgtccac 2159281 acgggcaact gattctctcc attcgtcacg ggtgtcatga ttggccggat tcatcagatc 2159341 gtcatagcgt acgtccaaga atttattcaa ccacttcttc tcgtctattc cgtctttagg 2159401 tgatccgccc gcttttttgt tcgtacgttt aatcaaggca taaaaagagt cagggtcatc 2159461 accatcgcca tgctgaataa ccgtatcgta catcacagct cttgccaatg ctgtttttag 2159521 tccggcatta tccgatcgtt tcatggcagg ctgataatac aaatggtcat ttactttgtc 2159581 ttgagcggcg cgaaattcct tatcatttgc aagcgacttc caggcagaag cgaatccctt 2159641 gagattgctt gtatcatcgc tttcttcctt ggccagacgg cgcaattcag gcagatactt 2159701 tttcagtttg ttattcggaa ctgcctttgt gtatacttcc actacttcca atgcatcccc 2159761 ggtagccgtt gtaaagcctg cccgtccgca tgtatagcct cgcccgtcat ccaatcgctc 2159821 tacatatcca tattggatct ccgttgtgcc gttttcaaag atacttgtca gctgttccgc 2159881 ccggcgcttt tgatctttat tcagtcccgc cgcaaaaacc gtttcgctca tcatcagggt 2159941 aaaaaacatg gtgaaaacaa gtaatgagat cgctgctttt ttccaaaaat ctgctttttg 2160001 catactgatt ttcatttcac ttcccctttc taaatattgt aaatacagac tcagtataca 2160061 tgaagaaact gccctattgt tgaaaataca tcaatttgtc aatattttga atctaaagta 2160121 atatagcttg aatcttactc tattcattgc caatcagcct tagcccctct cactgggaag 2160181 gtcccttgat tttcatactg cttcaacttt cattaacaag atgccataag gctttactct 2160241 attttataat ggaagtgatc atcgaaaatc gttagggagg tgatgtaatg gcaagcaaga 2160301 tgagaatgcc agattccgca acgtcccatg caaagcctac tattgggaag gcgatacttt 2160361 gcatggggta gactttctaa aagatcgccc aagtaagctt ttctgatata gtggctttgc 2160421 accttatttg acataaaaaa ataaggagct ggcagaaatg gcatatgtaa aagcaaccgc 2160481 tattttacct gaaaagctga tatcggaaat tcaaaagtat gttcaaggaa aaacaatata 2160541 tatccctaaa cctgaatcct ctcatcaaaa atggggtgcg tgttcaggaa caagaaagct 2160601 gatcgatgac agaaacgctt ctattaaaaa agcatttaaa aacggcaaaa ccattcatca 2160661 attatctgat gaatatcacc tctctattga aacaataaaa aaaattgtct actctaaata 2160721 aacaaaacgg aagcactgat aaaaaataat cagtgctttt tatatggcga gtttgtttct 2160781 tagttatttc ctgcatatga taccattggc caattgtgta aagttaaggg agatgagaag 2160841 aaaggaaggt cctacaaatg acgataaaca atggaacgtt gcaagtaccc ggcgcgaaca 2160901 tccactatca ggtgcgtggc tctggtccaa tcattctttt ggtccacgga ggaggcggtg 2160961 atgccgacaa gttccatcat gttgccaatc atctggctaa ctggtacacg gttgttactt 2161021 atgatcgccg cggccattcc cgcagcaatc tcgccaatca gattgagggt taccgtgtgg 2161081 aaacacacag tgacgatgct caccgtcttc tagccaaaat caccaataag ccggcctatg 2161141 tatttggaag cagctccggg gctgttatcg ggcttgatct gtgcatacgc catcccgaac 2161201 aagtacatgt catgatccca cacgaaccaa tcttattgca gcttctgcat ggaaatgagc 2161261 tgaaacaagc cgagcaattc atggaagacc ttaagaaaaa tcatcgaagt gaagtcatta 2161321 aattaatgtc aagattagag acagacgaac aatcaaaggc tgtcctgaca aagcggcttc 2161381 tcggcaattc aacgtatttc actgagtatg aaattcaagg aattctcagc tatacattag 2161441 atttcgaagc attaaaaact gtgtttacat cttcaccgat gaagatactc ccagctggcg 2161501 gaagtgcttc tcgggagctt tttccttatc gttgcgcgaa cgccctagcg gaacaattgg 2161561 aaacagaatg ggttgaattc cccggaaatc atacggggta cacaatgtac cataaagaat 2161621 tttctgagag gttacacgac atgttagaaa aagaaaagaa acatacgtgt taaggattga 2161681 ttaaaatttt caaaatagga caggtgaaac taactatgga attggagaag atttcacgaa 2161741 gcgtaaaaag aacttttcac taacgagaac gcaatgtgag atgtttaacc aaagtgatat 2161801 tagggatttc atcgaaaaat aggtttgtac attacgttct cctattgatt atttcctatc 2161861 ttaattccgt attttatacc attagataca actctaaagc ggctcgttat tttgtcctca 2161921 acaacaacca gtgtctaaca tcatgaatct cttttgaaaa tcaccacaaa tgcaggtatg 2161981 gaagacttca tcgcagcaaa aaccatacca actattgttg ttggtatggt tcgtcctaga 2162041 taggccctta agaagagatt ctattgtacg gagtatttag ctaattgcat ttgtaaccga 2162101 cagggccgtc tgaacctgtg tacacatatg tgtcagacac atatccaata ttcacgacac 2162161 cccgggaatc tttccactgg atttggtccc agatattact cgttccatac ttccctgtaa 2162221 cagtcgttcc ataagcgtaa caataataag gaacacggga gccactcgga atggaaagca 2162281 taataggata atttgtacca ggaccgctgc gcatattgac aggcgcaccg ctgcttgttg 2162341 agacagtaaa gtactgaacg gcaagtgcct gactggaaaa aatgaataaa gatgcaatca 2162401 tcacggttaa catactcagc attttcagtt tagtcaatgt catccctctt tcttcaattc 2162461 cttcatttta agaaacgata gaacataggc taccagctgc atttaggaac aaccggaccg 2162521 tctgagcctg tatacatata tgtatcagag acaaatccag gaacgatctc cccgctggca 2162581 agcgtccgct ctgtgtaatt ccaaatattg ctcgttccat actttccagt tacagttgta 2162641 ccggttttgt agcaatagat cgggatgcgg gttccgctcg gaatggtcgt tacaattccc 2162701 caacttgtac ctgggccgct gcgcatgttg acaggagcac cgctgcttgt tgaaaccgta 2162761 taatactgag ccgcaagtgc atggctagaa aaaatgaaca cagatgcaat catcaccgtt 2162821 agcatactta gcctctttaa cttattcacc ttataccctc cccttataaa tgccgtacgt 2162881 ttgactttct tacatccagt taaggattta ctttcagata ccatgccccc tcccctccca 2162941 tatatttatc aatgtaccat aaactagatc tttcaaaagt ggaattattc ctatgttttc 2163001 gacaattaag gatacaaaat aaatggtagt caggcttgat attgatggtg tgttacattt 2163061 ggctcttaat catttgtcca gtcggtaatc acgattgaca atcaggaaaa aggacatgga 2163121 tcaagcggct tcgtttccac caattaactc aatcagtgta ctgcttcctt gtatccacgc 2163181 ttcttctcga ttcatagata ctccaccttt ttcaccaatc aaaaacggac accatacaaa 2163241 tcagcgtaaa tgctgcaagt tcagtgtccg caacctatta tgactttgct ttcttttacc 2163301 agggcgtgta aaaatgatta ggtacgttat caaacgttat tctatgattt tgcgagtcaa 2163361 aaaatcataa cattttatat atttcaatca gattatgatc tggatctctg aagtgagcaa 2163421 ctcgggcact ccattccttg cgatcatgcg gtttattctc acatttaact cctttttcgt 2163481 gtaaatcgtc atacgtttta tcaacatctt ctaccttaaa ctgaagcaaa aattttgatt 2163541 gagcttctcc ttccaaggac tttttttcct ctccaacgat ttcagccatc gtttctcgag 2163601 ataaaagctc tattttcgtt tccccattat caaagagtgc atattccatt tcattctcta 2163661 accaacttat tggaagtcct aatgaatctt tataaaactc gacgcttttc ttaaaatcat 2163721 tcaccaacag tctaatttgt aacagcttca tatcgagtgc ctcctataaa accatacttt 2163781 tactggtcat ccaatttaat gataccaaag aaacctgaca gcactatgtc aagtttccat 2163841 acttcaccct tatttcagat ttaagtgcag tttagtccat gtcataagaa cgagcaaaaa 2163901 cagcgattct taaaacaaaa aatgataccg agtgtatttt ctgtatgctt caacttcatt 2163961 tcgggaaatg taacgttgat aaaaggaggt tacatcaata tggatcatca aacattggca 2164021 gctcatgagg ctgttgactt acatgaaatc gtgaacttta aaacactttg tatagcgaaa 2164081 tcaaagttaa tgcaagggct tgtgtttgac caagaactga aggacttgat ggaaaaagat 2164141 gtacagcaat ccattcaaga ccttactgaa ttacaagcgg tttatgagcg tgcctcattt 2164201 caggcccctg tccctcaaag ccgcccaacg ccaatcatca attgaaaggg aggtaagcct 2164261 ctttgaataa tgatcattta gaccccatta attcgctgaa tgtgcctgaa ctagcagaca 2164321 ctacattcgc gatggatttt cttatacgag ctaaggaagg cgtaaggaat actgctgtag 2164381 ctttgacaga aaccgcttca ccagatgtaa gagcactgct tcggaaacag ctgatgcaag 2164441 gaattgcgat gcaccaagag attacggaac tgatgatcag caaaaagtgg ttccatccat 2164501 atgagctgag cgaacagtat aagctggatc agctctctgc aaaaaacacg atcatggtcg 2164561 gcaatatgaa cctctttcct gatgaaacaa atcgcaaagg gatgtttgac cggacacctg 2164621 atgaacacta acactggagg ttttacagca tgaaggcagt aacgtatcaa ggcattaaaa 2164681 atgttgttgt caaagatgtc cccgatccaa agattgaaaa atccgatgac atgattatca 2164741 aagtcaccag tacagccatt tgcggatcag atttacattt aatccatgga ttcattccga 2164801 atatgcaaga agactatgtc atcggccatg aaccgatggg aatcgtcgaa gaagttggtt 2164861 ctggggtgac taaactaaaa aagggagatc gggtaattat tccctttaat atagcatgcg 2164921 gggaatgctt tttttgtaaa aaccagctgg aaagccaatg tgatcagtct aatgacaatg 2164981 gggaaatggg tgcttatttc ggctattcag ggcaaactgg cggttatcca ggcgggcaag 2165041 ctgaatattt aagagtgccg tttgcgaatt ttacccattt taaaatccct gaatcttgtg 2165101 aggaacccga tgagaaatta agcgtgattg ccgatgccat gaccaccggc ttttggagtg 2165161 tggataatgc cggcgtaaaa aaaggcgata cagttatcgt tctcggctgc ggaccagtcg 2165221 gcctgtttgc tcaaaagttt tgttggctaa aaggcgcaaa acgcgtcata gcagttgact 2165281 atgtaaacta tcgcttacag catgcgaaac gtacaaacaa agtagaaatc gttaattttg 2165341 aagaccatga gaatacaggg aattatttaa aggaaatcac gaaaggcgga gcggatgtag 2165401 tcattgacgc tgttgggatg gatggtaaaa tgagcgatct cgagttcctt gccagcggct 2165461 taaagcttca tggcggaacg atgagtgcat tggtcattgc ttcccaagct gttcgcaaag 2165521 gaggaaccat acaaattaca ggtgtgtatg gaggcagata taacggtttt ccgttaggag 2165581 atattatgca gcgaaacgtc aatatacgct ctggacaggc tccagtgatc cactatatgc 2165641 cgtacatgtt tgaactagta tcgacaggca aaattgatcc gggagatgtt gtcagccatg 2165701 tcctgccgct tagtgaagcc aagcatggct atgacatttt tgattcaaaa atggatgatt 2165761 gtatcaaagt tgtgttaaag ccttaaaaaa cggaggttac agaaatggaa tacgccttac 2165821 acgaagtgct tgaggttcag gaaatgactg catttaagac actttgtttg acgaaatcta 2165881 aaacaatgaa agcactggta tctgatccga agctgaaaga aatcatgcag caagatgttg 2165941 atatcaccac acgccagttg caggaatttg cctctatttt atctaatgca aagcaagaat 2166001 gaggagatga ataaatcatg aatcctatca tagaatatct gactggcatg aatgttctaa 2166061 cagaccaaat cattgctatg gacttattaa tttcagcaaa gaacggagtc agaaattatg 2166121 cgatggcagc cactgaagcc ggaacgcctg aagtaaaaga ggtccttatc cgccatttgg 2166181 aagaagcact cgatatgcac gaacaactct caagctatat gatggaaaaa ggctggtacc 2166241 atccttggaa ccctgacgaa caagtcaagc tgaatttaaa aaatattgat acagccattc 2166301 aattgccaac cctttaacat acaatgactg atttgctgag gaacagtatt gattggccac 2166361 aactgttcct cagcttcaaa atgagcactg tttgttcggg tcctatgacc gtaaatagat 2166421 taaccgcttt tctccatctg atctccgata atgtttgcaa attctccaat ccaaataagg 2166481 aatcgtaacc acctcttttt atgcgatctc ttgatggaga aaacaggcca gaaacaaaat 2166541 ccttcgtttt tgacctgccc tcttcacacg caaagaatgc taccttcttt gctccactga 2166601 tccgtgaaga ctttccgttt taggcctgct tttgagcttt gcctcatttt cacgcaattt 2166661 cccatcataa tctttaattt ttgtgtctaa tctcttaatt gtttcatcaa tttctttccg 2166721 cttctctatc agccgctgtc gttcgtcagc caggatattt tttcgagctt ctaccgtacg 2166781 gtcaccttcg gtaaataatg ttgtatattc aattagcgct tctatcgata gtcccgcatt 2166841 tcgcatgcat ttaatgaatt caatccattt gatatcttct tcatcatagt cgcgaatgcc 2166901 gctgtctttt cgttttacag gcgggattaa tcctacacgt tcgtaatatc ggagtgttgc 2166961 ggctgtcagg ccaaactgct ttgccacctg agcaatattc atgatcttca cctctctatc 2167021 ctgtatgttg tgaaggtaac acttaaagtt aactttaagt caagctcaaa acaagtggtt 2167081 agctgctgaa tctgggttta tatattcggg acttgcctta aagcacactt taaactctat 2167141 acttctccat gcactaaaaa cagtgtagtt ggagggattg ctgaatggca aataaacaca 2167201 ctgccggaag agaacaatta ggagaatttg cgccaaagtt tgctgaactt catgatgatg 2167261 ttctattcgg tgacatttgg gcaagagaag aagaactttc atcccgggat cgcagcatga 2167321 ttacagtttc tgcattaatt actgactgtt tctcagctta taaatcaggt tcattttaaa 2167381 tggttttttt aaaaaaccct tgccttaaag cagactttaa ggtttatcgt tatgttgaag 2167441 acaccataaa acataaataa gtgcatgttt ttatttacaa cacttatgat gaagaaagga 2167501 taggttcgta tgtgtaatca acatcaaacc cgtgtattaa gcgtgtcaca tgcaaaagcc 2167561 aaatttgaac aaacgacgat tgagcgaaga ggattacggc cgcacgatgt cttaatcgat 2167621 attaaattca gcggcatttg ccattcagac attcatagcg cttttgatga atggggcggt 2167681 ggcatcttcc caatggtgcc tggacatgaa atagccggtg ttgtaacagc cgttggaaca 2167741 aaagtcacca agttggctgt cggggaccgc gttggtgtcg gctgttttgt tgactcttgc 2167801 ggagaatgcg aatactgtct caacgcagag gaacaattct gcacgaaggg tgttgttcaa 2167861 acgtataact cagtagacta cgacggaaac cccacttatg gcgggtacag ccaaaaaatc 2167921 gttgtcactg acagatttgt tgttcgcata ccagatcgtt tggaaatgga tgttgccagt 2167981 ccgctgttgt gtgcaggtat cacaacgtat tccccgctga aacactggaa tgttggccct 2168041 ggtaaaaagg ttgcgattgt aggcgtaggt ggccttggac atttggcaat tcaatttgca 2168101 catgcgatgg gtgcagaagt aaccgtcctg agccgttcca tgaataagaa agaggaagct 2168161 ctggaactcg gtgcaaatca ttactttgca acaagtgacc cagccacatt cactgcattg 2168221 gccgggcgtt ttgacgtgat cttaaatacg gtatcggcaa atctcgatgt agatgcctat 2168281 ttatcaatgc ttcgtataga cgggacactt gtaagcgttg gagctcctgc caagccggac 2168341 acatacagtg tgttttccct aatcatgggg cgccgcagca ttgcaggttc tctagtcggc 2168401 ggaattcaag aaactcaaga gatgctggat ttcgcagctg agcatggcat cgaacctaaa 2168461 atcgaagtca tcggagctga ccaagtggac gaggcatacg aacgtatcct ccgaagcgat 2168521 gtccgttatc gatttgtgat tgatatttcc acattgtaat aggttagtcc ttatatgggc 2168581 tgccgctttt attgaaactc acgaaaaatg atctctttaa gcaaatattt tgaaggccgg 2168641 tcaatcttcc tgttattcta tgaatagaga gttattagga gggtttttta tgagcaaaaa 2168701 aattgcagtt cttgttacag accaattcga agacatcgaa tatacaagtc cggtaaaagc 2168761 atacgaagaa gctggctaca gtgttgtggc tatcgatttg gaagccggca aagaagttac 2168821 cggtaagcat ggcgagaaag taaagattga caaagccatc tctgatgtgg atgcaagtga 2168881 ctttgatgca cttttaattc ctgggggatt ctctccggat ttgcttcgtg cagatgaccg 2168941 tccgggtgaa ttcgcaaaag catttgtcga aaacaaaaaa cctgttttcg caatttgcca 2169001 cggcccgcaa gtactgattg atacggatct tctaaaaggc aaagatatca caggctaccg 2169061 cagcatccgc aaagatttaa tcaatgccgg tgcaaactac aaagatgcag aagtagtcgt 2169121 cagccacaac attgtcacaa gcagaacacc tgatgatttg gaagcattta accgcgaatc 2169181 tttaaacttg ttaaaataac aagaaggcac agactgttcg ggtctgtgcc ttttttaaaa 2169241 ttaagactcc ttcgttacat tctgaaagac agcagtcgcg tcccacacat tcaagccaaa 2169301 ttggccttct gaaaatacgg aatcatgtgc atcaatcaca agacgatcat ctaaatagat 2169361 tttaaagcga tcgccctcgg cctctgtttt cagatgatac tttttattaa cgtctatcgg 2169421 tgttttgtat tcagcaatga cagaagcagc accgttctca aatttaaaga atttcactag 2169481 gtcatgcttc gcatccacat tggcaaggta accgtttttg gcatctttgt cagagcgaaa 2169541 cattagtgct cctgcccctc ttccgtttcc atccttaatg gtgatatcag attcataagt 2169601 gaagtctgac ccggatgctg aagacaagat aaaggaatcg ccgtccgacc tcccttgttt 2169661 cccctcaatt gtgtctgccc acgtgccatt tacagtcgtc cagccagtca tattggacat 2169721 aaaaggtgtc gttccccata ccttttttaa agggtgtatc gttaaagatt ttacctttac 2169781 accgccattt gcagcatata attcaagccc tttgcttgat cggtctggga gaataatatc 2169841 cgttatgacc tgctttccgt cattcccaaa tacttcaacc gaggagcggt caacaaaaat 2169901 gcgcaactta accttcccat ttaccggctt caacggggct gtttcttttc cggtgttaaa 2169961 ggccggatta aaggtgtcgt tgcctgactc gctccggtca acgaacaatt tggcgttcct 2170021 tcggtcatag ccgaccttcg taaattgatt ttcacctgtt cggaccttaa aaccaaattc 2170081 agcagctgaa ccagggctta ctttaaattc tgcatttatt tcataggcat ctccagattg 2170141 ccccgctaac acattatgac ttgcaggcga tatggtcaga ttcttccact tcttagaggt 2170201 tccgcgaatg gtttccagct ctttcaccgg tgtttggacc actctaaccc cttcggtaaa 2170261 cgctttcaat tttaactctc ttggaatgga cgttgcactt ctccatgggg atgtcggaac 2170321 atcattcgca tattgccaat tgctcatcca ccctaaccat agccggcggc tgtctgtgga 2170381 tggaatatca gaccaggata cagccgcata aaagtctctg ccgtaatccg tccagagaac 2170441 tttgtttggc gggttttcat ttttaaaatg agttccatca aagtccccta caaaatattg 2170501 catgcctgat cctcccgaga ccgctccgtt tccgacactg acctgcatga cccatttctt 2170561 ttgattcgga ttgccgtcta ccggaagctc aaataaatcc gggcattccc atactccccc 2170621 gtggcttcct tgatcctgtc caaattcact tgcatacgtc cactgcttca gattttttga 2170681 tgtataaatg aggattcggt caccggccgc aagcaccatc acccactttt tttctttctc 2170741 ataccaaaag acttttggat cgcgaaaatc ttttttaccc gggtttggaa tgacagggtt 2170801 gccagcgtac ttcgtccatg ttcttccttt gtcgttgcta taggcaatac tttgcacttg 2170861 atggccttcc cgatcctgtg tataaatggc cacaagcggc ttctctttgc ctgtttgaaa 2170921 accgcttgtg ttatttttat ctacaactgc gcttccagaa aagatcgtgc ctttttcatc 2170981 cggatacagc gcaacaggaa ggtgttccca tgtaaccaaa tctttgctga cggcatgccc 2171041 ccaatgcatg ggcccccact gaagcccgta tggatggtat tgatagaaca agtgatattc 2171101 cccagcataa tataccattc cgtttgggtc attcatccag tttgcctccg gtgtgaagtg 2171161 atattgagga cggtaatcct catcatagta gcttgaatcg gctgcatctg ccgaaaatgc 2171221 catagtcaac agcagggtga acatgatcat gacttgaatc agtctctttt tcatttgttc 2171281 cttcgctcct ctcttcatgt ttgaacactt tcaaaagaga ctgctgcgca agctggtccg 2171341 tttctggcaa ttctcctctg tttcactgtt atccgaatga tttatatatg aaaagactgc 2171401 tgcagtttct ctctctttcc ttcacacacc ttatgctaag aatccagccc aatacccgag 2171461 aatcccgatg acaaagatgc cgcaaataat gagaagtgga ttcacccctt tgcgaagcat 2171521 ccatgccacc aataacgtta atccgagagg cagcgccccc ggcataatgc tatctagcac 2171581 gttttgtacc gtttgaacat ctacttttcc gctttcatcc ttaatcctgg atacaacgat 2171641 tggaatgttg atggtggtcc atttggacac gagagccccc ataacaaata acccgagaat 2171701 cgaagcgccc tctgtaagct tttgaatgcg attccccgct aaatcctgaa gaatctccat 2171761 tcctttcaca tagccatact ttaatccgta atattttgtg cttaatctta tggcattcag 2171821 caagaaaaag aatagcaaag gaccggcaat gtttcctcct aaagcaaggg aggctcctag 2171881 cgcagctaag acaggacgaa tcgttcccca aaaaattgga tcgcctacgc ccgctattgg 2171941 tcccatcaaa ccgattttca ttccgcttat cgcttttccg tcaattcctt tattgttcgc 2172001 catttcttct tccatggctg ccgtcacgcc aaatataggc gctgtcagcc acggatgtgt 2172061 attaaaccat tccaaatgcc gctgtaaggc ttcgtttctt ttcgctccgg gaccgtacaa 2172121 ttttttgatc gccggtatca tgacataaca atatcccatt gcctgcacac gttcgaagtt 2172181 aaaggaaccg agtaaaaaat ttgaacgaat aaacatgctg aaaatttctt tcttcgttaa 2172241 tcgtttttct ttctccattt tttcttcccc ctcatcgttt aggcatcaag atcatcatca 2172301 tcgtcatcat aaacagcaac actgccactg tctgatgcgg ccgcgactgc tccgtgagcg 2172361 ctttgttttt gcatcacctg ctggtataaa agcgccagac agagaccaag ggctccaaat 2172421 cccactaagt taaaatcggt aaacgccgct aataagaaac caatatagaa aaatggcttt 2172481 aaataaggaa tattcatcat attgatcacc atggcatacc cgacaaccac aataatgcct 2172541 ccgcctattt gcagtccttt tgtaatgaca tcaggaatat ttcccaggaa cgcctgaaca 2172601 gcgctgacac taattaaagc aacaatcaat gtaggaatca tgacgcgcaa agcttgaaac 2172661 accatcgcgg taatatgcat aatttcaatt ccttttatat ttcccgcttt tgcatattga 2172721 tcagcgcggt ggatgaaaaa gacagtgatc gtccgaacaa aaatcgtcag cgcctgaccc 2172781 gcagctgcta aagcaacagc gacagcaatc ccttcgccaa ttccttgatc agcggtaata 2172841 actaaaatgg ttgagatgac agaggcgatc gctgtatcag gtgccatggc aagcccgacg 2172901 ttcatccagc cgagcgccat cagctccagt gtgcctccaa gaataattcc cgtttttaag 2172961 tccccgagca ccaagccaac caacgtacag gccactagcg gccggtgtgt ctgcccttca 2173021 tccaatacac ttgcgattcc ggtgattgct gcaatgatta acaacaaaat aatttgtaat 2173081 gaagacatat tctcatcccc ttgattattt tgttacgttc cgtaaaatct gtacaaaatc 2173141 ctcactggca tctgaaggca gctgcctcaa ttccagtttc acgcccttgt cacttaatgt 2173201 ttcaaatgcc tttatatctt gttctgtgac actgactgat tttgtgattt gcctgcgatg 2173261 attttcaaaa cgcattcccc cgacgtttac ggttttgatc ggtacacctg cttctataag 2173321 agatacaata tcggacggat tttcaaacaa gagcattgcc gttacccctt cgtagcgcgg 2173381 actatgaaat gcttttgcca ttttagaaac cgagacggca ctcgccttta catttgaagg 2173441 cgcaacagaa aggatcagcg tttttctcat ttcgtcctga gcaatatcgt cggagacaac 2173501 gatgattcgg tcggctgcat ggacttttat ccaccttgtc aggatttggc cgtgaataaa 2173561 gcggtcatca attcttgcta acacaatgtt catcataatt catcctctct tgtatcttga 2173621 ttggctgttt ttactttttc taaatgttca ctgcacactt gaaagctttg ctgactcatt 2173681 gcttttaagt tgttcagcaa atctttgaga gccagatgtt ctctcaggct taatacctcc 2173741 agcagaatcg gcaggtttac gccggcagcc atatccattc tttgatcctc agcaataaag 2173801 gaagctgccg cgttatatgg cgtccctcca aaaatatcga ctaaaaaaag cacttcatgt 2173861 tcttccggga tatccttgag cgcctgatga tatttttctt gcagcgtttg tattccttcc 2173921 cctttgaaaa acggcactgc aatcaggtta ttttcttcac cgaatatcat ccctgaagac 2173981 tcttttaatg ctatgggaaa atctccatga ccgctgataa taactgaaat catatctatt 2174041 gctcctttcc tgttttgtac atccatatat aatgcaagga tcgtgccaac acagttgtgt 2174101 taagcgtttt cattgttatt tcagccaata gcaatttgtt gttgaaacac ttaaaacgaa 2174161 aaaaataaac ctgtattaaa atggtgttcc atttaataca ggttcatatg aaaaaactgt 2174221 ttttaaaaca gctggccatg cacttcttca gcaaatatgg cggctataaa taatttttca 2174281 tcatcactta tgcgaagtcc gagcttttct tcataagggg ctaatgttcg ctctgtcacg 2174341 tacaccattt ccttcagctg atcattgatc tcttcttcct ctgagaaagc gatcggattc 2174401 tgcttaatta ccctttcaaa ggcgaaagcc gtgtgcataa tgactttgat caaaaccgca 2174461 ttattgaaaa tgacccccag ctcatcctga acggtttgca gccactccaa taacatgtcg 2174521 atcacatggt ggggattcaa gaagacaagg tattttttca ggctatcctc gcaaagctcc 2174581 ctgacaataa tatttgcttc gttcaatcca ttgctcaagg agatgcttcc ttttgtaatc 2174641 gcctgttgaa tcagcttctc tccctcccct tcaattaaca cttctaaaga tacatgcgga 2174701 gcattgattt tagggtcttt cgttccgact gtcgcaagga tttcatactc tttttcgatt 2174761 tcttttatgc tgttggccag cttaatcgat gatacggtca atatgtgaat gggggtatcg 2174821 gaggccttgt ttacgatcgt ggttagaatg tcttccagct ttttggccgt tccgctaccc 2174881 gtcgtgcaga tggataccaa tgccttcttt ttgccggatg ccgctggctg acgctcccac 2174941 aactcgataa aatccttcgt gaccgattga tagatcgcat gcaaatttaa attcaaatag 2175001 ttgacctttc tgacagcatc cagcaccatt gaagtcgtaa cattgctgat cgttttaata 2175061 gaaatgcctg tcttttcctc cagcctgctt tccagcattg caagcgaccc catatctacc 2175121 agcattaaaa caccttcacc ttcatcaacc tgtttcattt tttctgctac gcattcaaga 2175181 atgtccgaag gtgaaacagt aagcggcatg tcaactgctg caatcggcgt actccctagc 2175241 agttctgtcg cgacttcaac cattgaactc gccgtgctgt ttccatgagc tgccacgata 2175301 ataccgactc ttttgttctc ctttaacgat ttgatggaat gaattaacat cgttaagtag 2175361 atgacttcta tttcaggaat agccacttta aaatattcct gaattttatc tttaaaaatc 2175421 atcgccaccc gatattcttt cacatgggta tcacgaattt catctgtctc ctgtgtattc 2175481 aaaacatcaa tttgctttcc tcgctttaaa aatgcgtcaa tatgcatact caagaaataa 2175541 ataaacttac ggtcaaatgt gcaatccagc tcatgttcag ctatttcttt taactgtttt 2175601 gtcatttgaa tcacatcgtc ttcaacgaat gtcagcaggt tgtctttttg aaaagcttga 2175661 tgatgaaaaa aacttctgac atgcaaatgg acatcagtca agatgtactg gttaatatcc 2175721 tttttggata aaccttcttt cataagcgtt ttcacttttt cctcaatcaa atgatataag 2175781 ttaaatgaga ggtcttcgtc aatttttgtt gtttcatctt ctacaatcgg agagataatc 2175841 gttgtaatat tgacatattc agaaatggct ttgcttcttt gcatgttttt gctgctggac 2175901 atccattctt gcttgatttc atcaggcaga tcgcgaacag tcagttcaat aacttcattt 2175961 ctgtcaaggt tatgcaaaaa tccgtgtgcg caaactaact gaacatttga tttcagctgt 2176021 ccgacattcc caaatttcgc agagtgaata agcgcattat agacatcgat atgcacactc 2176081 agattcttct taattcgctc tgcttctttc cctaataaaa acgtcgtcag atccactctt 2176141 tcattaagcg atcgttcttc aagcgaagga atatgaatgg tcattgggat tcttcgcaaa 2176201 aacgttttca atagtgcaga actcggattt tctgtagtcg cacaaataaa caatacgttc 2176261 gatgttcgtt tatgttcaga ttctccaagc ctgttataag aaccgctgtc aataaaataa 2176321 aacagcattt cttgtccctc gggagggaga cggtggattt catccataaa aagaatgccc 2176381 ccattggcct gttcgactaa acccgcctta tcctcggcag cacctgtaaa tgaacctttt 2176441 ttgtgtccga ataattgaga aagcaataat tgagggttgt tgtagtagtc tgcacagtta 2176501 aatgtaataa atggtgcgcc ggccttcaat atgtcagagt aaatggcaaa ctggtaaatt 2176561 cggttcgcaa aaagggattt accggaacca gtcggcccta ggaggagcat atgcagaccg 2176621 ttcggcggat aaaagacagc tgcttttgcc tgggagatcg ctttcttcaa actccctttt 2176681 gcccctatca taagctctag gggattcgtg gaaatgtgtt gatgattttg ctttgaattt 2176741 ccggaaaacg cctgaaggtc tttcacttcc atcatctctg tatcccattt cttgttgaat 2176801 aatttttctg ctatctcgac tgggatgtat cttacaggaa atgttttaat tttgatgacc 2176861 tttttggacc ggacgagatt gttcaattca aagctgacat tggaccgctc cattttcagc 2176921 tgctcggcaa tctcctttgc tgaattccct tgtattttta aaagatgatc taaggttgaa 2176981 tcatgaaaat tatgcttgag ctgatggtat attttatcta ttcttctcac gtctatcatc 2177041 ctttgtcctt attagataag ccattaacaa gaatatttcg aaactttata gtccgcgttg 2177101 agatttacac gtttaaaaag gtctctatag cagattgaca aagctggctt ttatgcgtat 2177161 atgtttacat gttgaatcat ttgcacctca tattagtatg atagatgctc agttctggag 2177221 ggccagtccc cttcaaaagt aataatcagt aaacagttta tcattctcgg ggaatgtaat 2177281 gatgtcaaaa taatcaatga caaaaaatga atcttataga tcatgacaaa ttacccaaat 2177341 ataacccctt aagttcgttc acaactaaaa agacggacac tctatgtgac cgccacagta 2177401 ttacaatttg caaaacttcg tcatttttgc aatccacatt ggaggttaag gaatctgtaa 2177461 gcttaaaaac tttatctccg atcctatcga tttgatcccc ctgccggcct caatcatagt 2177521 gggtatgcaa ttatacaaat cgttaccgat taaaactagc ctgtcagatt gtccaaatga 2177581 ctttcctgtt ttactctgct attcaggtag aatcacgagt gaaaaataga gccacaagac 2177641 atgtaacagc acttaaaata gttttaaaat ttaaaaataa aagtatctat tcttttaaat 2177701 gttataatat ccgataaaac tttactcatc tttttattac tggaggaaaa taaaattgat 2177761 aggcaattct agcaaagaca attttggcca gcaacagaaa ttgtctagag gccttaaaaa 2177821 caggcatata caattaatgg cgattggagg tgcaatcggt acaggtttat ttttaggttc 2177881 aggtaaatcc atccattttg caggaccatc cattttattt gcttacttga tcaccggcgt 2177941 attttgcttt ttcattatgc gttcgctcgg agaactgctc ttatcaaatg cgggatacca 2178001 ctcttttgtt gattttgtaa gggactattt aggaaacatg gcagcattta tcactgggtg 2178061 gacctactgg ttctgttgga tttccctcgc gatggctgat ttaacggcgg tcggcattta 2178121 tacgcaatat tggcttcccg atgtgcctca atggctgccg ggtcttcttg cgcttattat 2178181 cctgctgatc atgaaccttg ccaccgttaa acttttcgga gaattagaat tttggtttgc 2178241 attgatcaaa gtcattgcca tactggctct gatcgtaact ggtattctcc tgattgcgaa 2178301 aggtttttcc gcagcttccg gccctgccag cctcaacaac ctttggagcc acggcggcat 2178361 gttcccaaat ggatggcatg ggtttatcct atctttccaa atggtcgtct tcgctttcgt 2178421 gggtattgaa cttgttggac tgacagcagg tgaaacagaa aatccccaaa aagtgatccc 2178481 taaagccatc aatcaaattc ctgtccggat tttacttttt tatgttggcg cacttttcgt 2178541 gattatgtgt atctatcctt ggaatgtgtt gaatccaaac gaaagcccat ttgttcaggt 2178601 cttctctgca gtaggcatcg ttgtggctgc cagtttgatc aattttgttg tattaacatc 2178661 agccgcatca gctgcaaata gcgctttatt cagcacaagc cgaatggtct attcacttgc 2178721 aaaggatcat cacgcacctg gactattaaa gaaattaact tcttctaacg tgccaagcaa 2178781 tgcgctgttc ttttcatcca tcgccattct gattggcgtt agtctgaatt atttaatgcc 2178841 cgagcaagtc ttcacgctga ttacaagtgt ttcaacaata tgcttcattt ttatttgggg 2178901 catcacggtg atttgccatt tgaaatatcg aaaaacaagg cagcatgaag cgaaagcaaa 2178961 caaatttaaa atgccttttt acccattatc caactattta acacttgcat ttctcgcgtt 2179021 cattcttgtc atattggcac tggcgaatga tacacgtatt gctttgtttg tcaccccggt 2179081 ctggtttgtt ttattgatta ttttgtataa ggtgcaaacc cgcagaggac ataaggtgaa 2179141 ataaaaaaaa gacaagggat actcactccc ttgtcttttt atatgtgtca aacactaaat 2179201 taaactttgg tttcaaattt cattcacttc atttaagtgt taactcaaac cagttttgat 2179261 gccgaaacct actaatatta ttccggtaat tttttgaaac actttctgga acttcgagtt 2179321 tttcatccat ttttttgcgt aatcaataat ataaacaaga aacaggaacc acaacaccgc 2179381 taataaggtt aggattgaag ctaaaatgat gagctgctgg tttatatttc cgttcaaatt 2179441 gataaattgg ggcatgattg taacatacac caaaacagtt ttaggattga gaatgttact 2179501 gagtgatccc tgcataaagg aagttttata ataacgtttc ggagaacttg ccatattttt 2179561 tgcttgggat tgcatgtcat ctaacgaaaa catactttta gcaaaaaaac tttttacacc 2179621 taaataaatt aagtatgccg ctcccaaata tttgatcgtt gtgaaaagaa tcactgactt 2179681 tgcgattacc actgataatc ctaaaatggc aatcaccgtc caaaaggaaa gtcctgtcgc 2179741 caatccgaga atgttataac ggccggcttt cggaccatac ctaagcgtat ttttcatcac 2179801 aagcatcgta tctgcccccg gtatgataac catcatggca gcgatcggta tgtatgcgag 2179861 taagctgtgc attgttctct ccccctttaa aaatcccctc aatcatatag tgactacaaa 2179921 agtaactact tataaaagtg tatcaatgcg tttggaataa atcaatatga tttgttaaaa 2179981 tagcgattac taaggcagcg attgctcttt atattggagg atatatgaaa gaaaatatgt 2180041 tagacatttt aaaaaacctc aattttacag aatatgaatc gaaagcgtat ttagcattat 2180101 tgcaagaatc acctttaaca ggctatgccg ttgccaaaaa atccggagtg ccccgttcta 2180161 aaatttatga agtattggaa agtcttgtca taaggggaga tgtttttgtc agtcatggaa 2180221 atacgcctca gtatgttcca gtccccgcaa aagaactgat taaaaaccgc cggctcaaag 2180281 cggaagagca ttttgatcag gctgagaaat attttgaaaa gttcgagcag accgcaaatg 2180341 accgggaaaa catctggaat atcaccggcc gcagtgaaat tcttgaaaag gtgaaggctt 2180401 gtatcttatc tgccaaaaaa agaatcctct tagaaatatg gaaagaggat tttaaggaga 2180461 tagaagcaga gctcaaacag gcggcagaac aaggcgttat tgtcaccatt attgcgtacg 2180521 gagacatcgt atctgatttt gccaatgttt accttcatga tatgagcagt gaaattacag 2180581 aagagtatga cggacggtgg cttgtctata gcggagatga ttcagaagta gtagcgggca 2180641 ttgtctcact tggcaacgac agccgtgctg catggacgat gcatgtaggg ttagtcatgc 2180701 ctattactga agtgatcatt catgatctgt acctcatgga aattctgaaa aagcatagag 2180761 agcttttaga agagagcttc gggaaaaatc tcatccagtt gcgccgtaaa ttttctattc 2180821 actcagattt caaaaaacat tatttggaat aatgtttgtc atctcttacc ccaaaaacaa 2180881 ggcttgtaca aaacaagcct tgttttttta tgcataaacc ccccatgctg atttacttct 2180941 ctcttttaaa aaatgtgatt ctgcgcaaac tatttttcag cctgccgcgt ctatcctagg 2181001 taacagccta cgatatacgt atattcaaaa aggagccctt tattgcaatg aagaaaaaac 2181061 aaacaacaaa agcgttgctt gtcacatgca taactgacca taagcaagat ttctacaggt 2181121 tggctttcag ttatgtgaaa aatcaagatg acgcattaga tattgttcag gaatctataa 2181181 aaaaagcgct gagctcagtt gaaacggtca ggaaccctga gacgataaaa agctggtttt 2181241 ataaaatttt agtacggaca gccattgact ttttgcgcaa acaaaaaaag ataagagtga 2181301 tggacgacga aacgatagaa tttttaagca aaggaaagga agaccattac aaggatactg 2181361 atctccatga agcgcttgac gaattgccgt accgctataa aaccattatt attttacgtt 2181421 tttttgaaga cctcaaatta gaagaaattg cggaaattac aggagaaaac acgaataccg 2181481 tcaaaacgcg cctatacaga gcattgaagc tgatgcgcat tcagttgacg aaggaggatc 2181541 tttcttaatg gataagagat tacagcaatt aagagaagaa tataaaaatg ttcagattcc 2181601 taaagaattg gatatcattg ttgaaaaagc ccttcagcaa gaaccaaaaa agaaaagaat 2181661 cgttatgtgg ccgacatcag cagcaatcgc tgcagctatt ttattcactg cgcttgttaa 2181721 tatcaacccg gacgccgctc aggctatgtc aaagatccct gtcatcggca aaatcgtcaa 2181781 agcgatcacc tttattgaaa tcaaagagga aaaagaccaa tcaagcattg atgtcaaaac 2181841 acctgctttg tccgggcttt ctaataaaga gcttgaaaac agcattaacg agaaatactt 2181901 gaaagaaagc cagcagctgt ataaagagtt tatacagtcc acatccaaaa acaaaaaagg 2181961 gcatctcagc atctacagtg attacgagac ggtcacagac acgccagatt tactctctat 2182021 ccggcgcaat attgaaacaa cacaagcatc ttcctacaca caaagccgtt atattacaat 2182081 tgacaaaaag aatgatattt tacttacatt aaaaagctta ttcaaagatg agcgctatat 2182141 caaagtcatc agtcaaaaca tcaaagaaca aatgaaacag caaatgaagg aagatccaaa 2182201 taaaatatat tggctcactg acgaagatgc agaaccgttc aaaacgattc ttcctgatca 2182261 gacgttttac attactgaag accataaact tgtgatctca tttgacgaat atgaagtcgc 2182321 ccccggctat atgggcgtta cagagtttac aattccaacc ggcgtcattt caaacttgct 2182381 cgtgggagaa cgttatattc gataaaataa aaacatccat ctaagattat ggatgttttc 2182441 tctcttctct attcgaggtc gtaaccccgc tatcaaaaac aacgagaata tttgcatact 2182501 attggaggaa tacccatgta tcacaagaca cagcatcatc gatacattcc tggacttgat 2182561 ggccttcggg ctttcgccgt cctgtcagtt atcacttatc acctaaattt caattgggct 2182621 aacggtggtt ttatcggggt tgatatcttt tttgttttat ccggatattt gattacatct 2182681 attctattac cggcatatgg aaatgatatc aatcttgatt ttcgggattt ttgggtgcgc 2182741 cgcattcggc ggcttctccc ggcagcgtac cttatgatct tttccactgt tgtgtgggtc 2182801 gtattgtttg atcgagaact attgcacact gtacgtggag atgcgatctc ttctctcttt 2182861 tatatgagca attggtggtt tatttttcac aagctatcat attttgatag tttcggttcc 2182921 ccatcacctc taaaaaacct ttggtcgctg gcgattgaag aacaatttta tatcatatgg 2182981 ccgatgtttt tagttgttgg aatgtacata atgaaaagcc gcgccagatt ggctgcggtg 2183041 atatcattgc ttgtgctttg ttcagccgtg atgatgagcg tactgtatga acctggcgga 2183101 gatccgagcc gcgtttacta tggcacagac actcgttcgt ttgaacttct catcggatgt 2183161 gccttggctt tggtatggcc gatgaaaagg ctgtcttcca acaggctgcc aagcaaactg 2183221 aagcacactt tgcacgccac tgaatttttg gcattttgta ttttagtgtt gtgtgtctat 2183281 ttcacagatg aatacgagcc ttttctttac agaggcggaa tgctattcat tagcgtgact 2183341 gccgcaatcc ttattgcatg tgtttgccat ccgagcagct ttttaggcaa tctgctttca 2183401 tggaggccgc ttcggtggct tggaacgagg tcttacggaa tttatctttg gcactaccct 2183461 gttattgtgt taagcacgcc agttcaagaa atcggaaacc ctgttttttg gcatatcgtg 2183521 ctaaaggtca ttgtgacatg tatacttgcc gagctctcct accattttat tgagaagccg 2183581 atacggacac agggatttag gtcattttcc cgccgtgttt ttatacatag aatcaaggaa 2183641 tggaaaacga catctgtcat cagcaaaatg tcaattggtt tcattatttt cgctatactt 2183701 atttttgcag gcgggctgtc agggctagcc ggcgagcaaa agcaccctac caaatggacc 2183761 tatagctcac aagaaacaaa tgctgacacc agccaggctt ctggggataa aaagaacgct 2183821 gcagcagata aaaaacacaa tcctgaacaa aagacaacag attccaatca gggtcaaaag 2183881 gaaaacaaag atagtgggca agagactcat aaaaagaaag acacgcaatc ccaacagttg 2183941 aaaaaaccag cagacactgc gaaagaagtt ttagctatag gagattccgt catgcttgat 2184001 atttcttcac acctgcgtca gtcattttca aatgtgacga ttgatggaaa ggtagggaga 2184061 caaatgtctc aagctttgga actcgcaagg gaatacaagt cttttaatca gccgaacaag 2184121 gctgtcatca ttgagcttgg aaccaatggc tattttacaa acagccaaat cgaacaactg 2184181 cttcaatctt tctcaaaagc tcatatttat cttgtcaata cacgggttcc ccgccaatgg 2184241 gaaagcaagg taaatgaatc tttgcagcaa caggcccacg cacatcaaaa tgttacgtta 2184301 gttgactggc atacagaagc tcttcagcat ccggaatatt ttacccctga tggtgttcac 2184361 ttggttccta aaggggcaaa aactttgact gctcttattg ttcaggcgat gaaatcgtaa 2184421 aaaagagatc ctatacagat cactttttta ctttagtttc tgatcgttga ttatgtcttc 2184481 tttcagcaag gcagccctta tgtttacatg ccgtttacgt aagggtaagc caaaattgaa 2184541 tggagggatg ataatgaaag gaaatgaaga acatgacatc caaaaagagt tgaaacgata 2184601 tgagcttttt ttcaaaaaac gatataaggt tctttataca gtaaacgatt ttatcatcgg 2184661 tgctatgttt ctcgttggaa gttttttctt tttttatgac cggttaatgt cggcagggat 2184721 atggctgttt gcgatcggaa gtttgctgct gttaatcagg ccgaccattc ggctgattca 2184781 tgactttcat taccgtaagc atgtggaaca gcaattcaag catcaatctt caacagatga 2184841 ctgatcttaa ggaataagaa agaacaaaat gccaaaagcc tgagtcgaaa atcaaaaaca 2184901 agactttcag actatttatt tttaaaaaca aggtaaaaag aactaaactt ttgcctctgc 2184961 atgccgatat gaataataag gccggcgcga tactccctat aacatccttt tcagtagatt 2185021 tcattatcgt gccggttttc tcatatgcaa agcaatcccg ccaatcagat tggcgggatt 2185081 ttatatttta cattcctgtc caaacgtctt tcacataacg tctttgatct tgcagctttt 2185141 gcagccatac agctgattct tcctgacttg ctgctttttc agcttcatat gccaatcgca 2185201 aagttctctc tacatcagga gccatttgcg atccatcacc gcatacgtaa atatgagccc 2185261 ctttttcaat gagtgtcatc aatttctgcg tatcttgctt gagcaagtgc tggacatatc 2185321 cttttggttc gttttcgacg cgcgagtagc atcggcggat tgtgaccaaa ccgtcctgtt 2185381 ccgcttgatc cagctcttct ctgtaaaggt cgtcatggtc cgggcggcgg cagccgaagt 2185441 ataaaagtgc ttcaccaagg gtgcttcctt ccttcttcaa aaccgatctt gcctgaataa 2185501 agcctctgaa tggcgcaatt cctgtgcccg gcccgaccat aatcataggc gtttcaggat 2185561 cattcggcat ctgaaatccg gactgcggcg tacgaatgaa gcaagctgct gcatcacctg 2185621 tattcaattc tgctaaataa ttagaggcga caccccggta ttcacctcgg ccgctccatg 2185681 ctgaggcttt cacaactcct accgtcatgc tcacgatatt tgcatgaact ttcggtgagc 2185741 ttgaaatgga atagtatctc ggttttagtg atggcaaaag tgctaaaaac cgttcaaacg 2185801 gcatttcgca agcaggataa tcctctaaaa aatcaagcat ggtaagacgt tttgcaagta 2185861 cctgctcttt gtaaatgcca tcatctgaaa cgagctgttc cagctctttt tgatgcggcg 2185921 gacaaactgt ataagaggcc agctcccgaa gctgaagcct tgatgccggt tcctgcagct 2185981 ctacatagga cgacaataaa tccactactt tgattggccg atccatcggc agatgagcca 2186041 tatgagcgct tccgcttact tttatcacat gattggactg caaaccgaat cggctgagaa 2186101 cccgctgaac aagctccctg ctgttctttg gcaggattcc gatatgatcg ccttctttat 2186161 atgttttacc agccggaatt tccaattcaa tatggcgggt tgaacgcgtg ctggcagctg 2186221 tctggagttc tcgattctct aacacaatcc cttcaaacgc gccatatgct ttagcaaccg 2186281 gcgtttccgt cgcttcactg agaaaagtaa tcgataatga aggcctgtct tctttctggg 2186341 ctatttcgtt aatatcaaat gcgtccatcg tttccttcca gaagcggttt tcccaagact 2186401 cgcggtggct ttcaaaatca tcggcggcgt caccttcccc aatcgctgtt aaacgcgatg 2186461 ccccctttgc tttcatcatg tcatcaatca ggcggggaat ccgctgatac gtgctggccc 2186521 agctccggtt tccgcagccg aataccgcat aggaaacacc tttcaattgg ccttcctcaa 2186581 gctctttcag ccactctaca aatccggcag cattatcagg cggcgcccca ttataagaag 2186641 ccgttacaat gacgactgcc ccttcttcag ggagcttgcc gatataatca tcaagcggag 2186701 ccgtttcagc tgtaaagccc atctggcggc cttgagcagc cagttcaccg gctattccct 2186761 cagctgtccc aagatttgaa ccaaaaagaa caagtaaagg tgtgccgtgt ttaggtttgg 2186821 tttcttttgg ctttgtttct gctttgatgt ctgcctgttc ttttctctgt acattgattg 2186881 ccgctgtttt tcgcggtttc acagtaattt taaaatcatc cggcttgatc gttaatgctt 2186941 ctttgatttt tagttcgtag ccagtatggt ttatcaattc aaaatgcttt aatacaagac 2187001 cgagaaccat tgtcgcttct tgaagagcaa actgcatgcc aatacaagcg cgctgtccgt 2187061 ttccaaacgg cttatacgca tggtgaggga tacttgaagg atcctcaaac cgttccggac 2187121 ggaaatcttc cgcatccggt ccccaagcgt tttgatcccg gtgcagtttt ggaattaaaa 2187181 cagtgactgg ctgccctttg ctgatcggat attccccgcc tagaacagta tcctccttcg 2187241 catatagaga aaaagccgga gctgttggat acagtctgag ggtttcattt aaaaccatcc 2187301 gaatgtattt gagctgctgg atttgtttat attcaggcgt gtcatccgtt aacacgcgat 2187361 ccgcttcctc ctgagctttt ttcagttttt ccggatgtgt aagcagacaa taaatcgcaa 2187421 aggatagcaa cccgcttgtt gtctcatgtc cagcaattaa aaatgtgatg atttggtatc 2187481 gaatgttttc gtcatccagc gtttcacccg ttactggatc tttggcataa agcatgagag 2187541 acaagagatc cttaatgttt tcatccggat tcgcctttcg ctccgctatc attctatcaa 2187601 ccagggagtt catgacttct atatcctttt ggaactgcag cttcgttttc accatcattt 2187661 tatcttgcag gcccagtctt ttcgattgat tcatcgcctc ttttaaggca cggagcatac 2187721 tggtgataaa cggatgctgt gaatcacggt aaaagctgtt gaatcgatag ttaaacccgc 2187781 ataacccaat cgtatcaagc gtcagacgtg tcatatcgtc cgctacatca atttcttcat 2187841 tagggtttaa ccggctccac ttttgaatca gctgggttgc gatatccagc atcatagaat 2187901 gatagccttt catcgctttt tgactaaaac tcggcagcaa aatgcggtgg gctttttgcc 2187961 agttcggttc gtgcgtccag cttgtaaata agccatctcc cccgaactca cgcacctttt 2188021 gcaagccttt gccaaggttc ttgtcaaagc gtttttcatc acacacttca gccacaagat 2188081 tgtggccgga cacaaaaaca ctggatactc ccggaaaatc aaaacggaaa atcggtccca 2188141 attcatcagc tatccgccat aaggattgag aaagctgttc tttttccaga tgcggaagat 2188201 tttttaaagg tccgtatgtt ttgggctgag gtattgcgct tgcctgtttc attaacatct 2188261 ccctttccta tttttgtgat gaatgaagct taatggcgtc ccagcagcat tgttccaatt 2188321 cagtaattaa atcagtgtcc atctctatat cacctgtttg aacgagctga tatatcttga 2188381 gaaacgcccc taatacaatc gcaattaaca cattagaggg caggctgcga atcacgcctt 2188441 ccgcttttcc cttattaaaa tagtcatcaa gcatttgagt cagattttct atcatttttt 2188501 tgcttgtatg atttaagtaa tgagcgtctt ttttggtttc aagaaaaaaa agcgcatagt 2188561 cgctctcttt cgtaaactga acgagacagc aaaatacgtg gtgaaagcct tctctgacag 2188621 gcaattctga aacgtcttgc ttcagttttt ccgtaaatcg ctggatgctt tcttgaaaca 2188681 gtacgttaac gagtgtttct ttgctgtcaa aataacgata gatcgttcct gtccctacat 2188741 gagcacgttc agctatcata ggaatagtgg tagcgtcaaa acccctttcc gtaaaaagtg 2188801 agactgacgc tttcataatc atgtcgtatt tactgctgga tgcggatatc atgtaatctg 2188861 acaacctccg attcgtttac ggaatgaata ttcattcctt ttgttcacaa agaatgtctg 2188921 ccctgtctga tatcacctct ttgttctttc ttctgttata agtttatatg aaaaaaactt 2188981 tttttaatat aaagtatatg caaaaaataa aaaattaaga aaatataccc aaatcctaat 2189041 acgaggatct tggatatatt tcccgagaaa ttttttattt aacagccaca atacatagac 2189101 aggaagcacg cctgataaca gaaagatccc tgaaatgctg gtctttcagc agttgaatat 2189161 acgttttctc tttttcaccg gtatttgtgt caatactgat ataaaaccgg ccgtcaattt 2189221 gaagcaccct gtaaatttct cttaatgcaa gcctaatatc ggtgcagctt tgaaccgtat 2189281 gtaaagaaaa gactttatta aaggtacggt catcaaaggg aatgtcctct ggatagccat 2189341 gaaaaacctc cccgttcccc atgttctttc gattcgcacg tgatatctgt cttacctttc 2189401 gttttgaagg atcaatgctt tttaggctac ccttttttag tttcttggtt atgcttttaa 2189461 agacagtgcc gtttccaatt ccaatttcta aaattctgtc attttcttgt atatctatag 2189521 agtcaatcat catatgctca attgttttgg ttagcttata tttccgagaa aataatttcc 2189581 aaaaatccga tcgtttatag agtctatttt ctagcatttt aaacacctgc ttttggtttc 2189641 ctatgtttat ttattatctt aaaaaaataa acatcatctt catttctaaa agtgaaggaa 2189701 ggtaccaact agacggcaat gtattgaaaa atgtttcaat agaactaaac tttttcattt 2189761 ttttccgaaa aaaaagcaga aaacataatg ttttctgccc tctttctaat gccaatgata 2189821 agggaataca tacagccttt gctgctgcat tgccatcagc ctctgctgtc ggaatggatt 2189881 tccataacca tgtttgaagg aatgcggcat ggacgcataa ccatggccaa tcgacggcag 2189941 tcttttttga taatcgttca tcatgccatc acctgcctca caataacgtt gatttactat 2190001 atgcaggcgc gcattttctt gacagctatt tcgctaaact tggtccttct ccattgtata 2190061 atgcatcaat agttccattc taagcatatg ccattccccc ttcagttttt ttcgttgctt 2190121 ttagcgccag tttgttaaat aaagatgctt taactgagac tctttcattt catcataaat 2190181 ttgttcaatc tgctgttctc gttcgaattc ttccaggctt ttaaaccgtt ttttaatcgt 2190241 taacgttaaa aagaataggt taatcgtcat atcgctcacc ccctttcaaa gtccgcatca 2190301 agcgaaataa cccgcggcac aacccttctg ccgcgggcaa ataaaaaccg cagacaaaag 2190361 aagacaccaa tgcctctact gcctgcgggg agttgcgtat gtccgactat tccgaattta 2190421 atgcgtgcga taagcatcgg ttaaggaagg acacgaactc ttccacaggc tgaataaacc 2190481 atgaactttt acatgtgtat cacgtacagg ttgacgtcgt tgtctcattg tcattttggt 2190541 tcagcctcct ttgctttttt cttactttgt aagtatatcc accaaattcc attttgtaaa 2190601 catctttttc taaaaatgga cggaaattgt gcaaatcatc gaatggattt gcccgttggt 2190661 catgacacct gcttcatttc ttttctggag cggtctttct tatgatatgc aataaaataa 2190721 atgagaccga caaatacagc tccgccgatg acattaccga taaaagccgg aatgatgttt 2190781 ccgatgaact gcccccacgt gaatgagcct gcaaaaatgg cagcaggaat cacaaacatg 2190841 ttggcgacaa cgtgctgaaa tccgatagcc acaaaagcca tgattgggaa ccagatgcca 2190901 aggatttttc ctgctgcgtc ttgggcgccg aaagaaagcc acactgcaag acatacaagc 2190961 cagttacagc cgatggcgga aatgagaacc ttgccaaagc tcatatcaag ctttccttgg 2191021 gcaacggcaa tcgttttttc taaataagga cctgtttcag tcaatccaac caaatgcccg 2191081 aaaaagtaag caacaaacaa tgcgccgatt aagttcataa ttgtgacgat tccccagtta 2191141 atcgctaact cttttactga tatttttctc gaaaataacg ccatcgcaac tgacatcata 2191201 ttgcctgtga tcagttcagc gccagcgaga acgacaagga tcaggccgac tggaaatact 2191261 gctgcaccaa tcaaactgga caggctcccc cattctttcg gaagatcgcc aattaccctg 2191321 atatcaagca aatacccaag cgcgataaat gcaccgccta aaaaccccag cacaagcagt 2191381 gacggcagcg ggagctttat ttttttcatc cctgcttcaa ttgctgcttc cgctatttca 2191441 tccggttttc gaaaagccat aataaaacgc ctccattact tcttcttttc tcacagttat 2191501 gcaagaaagg caataaaaaa ggcagcactc aaataacctg tgtcaaacca ggcgtttgaa 2191561 tgctgcctaa cttgtatgca tacccataca acaatatcaa gcagtatata agatattgaa 2191621 agagaatata tacagttcgt gcatacattc cattgcttta gccttctata actgtagcaa 2191681 catcatatca aatgtgacaa atttgtgtca atgacaaata tactagcttt gcagagcttc 2191741 tttttgctca tctatttttc ggtcaaaaac aaatacagat acagcgatgt tttcctcaat 2191801 tttaatatca gaaaacaaat ggactagctt agctcccata agttcctcca ttccttccgg 2191861 tgtttgtttg gaataaaggt cttgaattag gcttgtccgg gccgcatgta ccatctctct 2191921 tccttcaggc gtgcgggcaa taaactgctc gcttgcactc agatttccgt atagtgttga 2191981 aactgccatg ttttctacaa atacagtatg aattctctca ggcccttttc cgaacaattc 2192041 tttgcgaagt tttcgaataa tatcattgaa ttcatgaatt tttttagaca tgctgattac 2192101 cccttccgat attgccttat aaaggctttt cccggttccc ctcaggacat ttcacttggt 2192161 taaaattttc ctgccatatt gtattataat aaatatcaca ttataataaa agcagtgttg 2192221 atggatttgt aataggatct tgttatgagt ctatcgtttt ataaaaatca aggattggtc 2192281 tgttagtaag acttgctagt gaactattcc gccatgtgtg tttacacctt cttagaatta 2192341 agggcaggtg tatctataca tggctttttt tgacttcttg aaagaaagat ggaggggaat 2192401 atgaatatga tggacgttaa gtcgatcagt gtccgtgtag acggaacaga aattcaagca 2192461 cgagcagggg ccacaatttt agatatttta aatgaaaacg gaattgagta cccgcagatt 2192521 tgccacgtac cagaggttga cccgattcaa acttgtgata cttgcatagt agaggcaaac 2192581 ggcaagctgg ttcgttcatg cgcgacggtt gcagaaaacg ggatgtctat tgatctttca 2192641 ggaaatcgag tgaaagaagc gcaaaccgaa gcgatggacc gccttcttga aaatcatttg 2192701 ctgtattgta cagtttgcga taacaacaat ggaaactgta cgctgcataa tacagcggaa 2192761 atgatgggga tcgagcatca aaaataccca tacacgccaa aagaagatcc ttcttgcgcg 2192821 gttgatatgt ctcatccttt ttaccgctat gatccaaacc aatgtattgc ctgcggccag 2192881 tgtgttgagg tctgtcaaaa ccttcaggta aatgaaacac tctcaatcga ctgggaacgc 2192941 gaacgccctc gcgtcatttg ggatgaggga gttccgatca atgaatcttc ctgtgtcagc 2193001 tgcggtcagt gtgtaacagt atgtccatgt aatgcactga tggaaaaatc aatgctcggg 2193061 caggctggtt ttatgacagg cattaaagag gacgtcatgg aaccgatgat tgatctcgtg 2193121 aaaaatgttg aaccggggta tggcagcatt tttgccattt ctgaagtcga agcggcaatg 2193181 cgtgaaacga gaacgaaaaa aacgaaaact gtatgtacgt tctgcggtgt cggatgttca 2193241 tttgaagtat ggacaaaagg acgggatatt ttaaagatcc agcctgtttc tgatgctccg 2193301 gttaacgcaa tttccacatg tgtcaaaggg aaattcggct gggattttgt caattcaaaa 2193361 gagcggatca caaagccttt aatccgtaaa aacggagcct ttgtggaatc ttcttgggaa 2193421 gaagccctcg atcttgtcgc aagcagatta ggatcaatta aagagcagta cggtaaaggc 2193481 tctgtagggt ttatttcttc ttctaaaatt acgaatgaag aaaactacgt cattcaaaaa 2193541 ctagcgcgtc aggtatttga aacaaacaac gtcgataact gctcacgcta ctgccagtct 2193601 cctgctacag acggattgtt ccgcactgtc ggcatgggcg gtgacgccgg cacgattaaa 2193661 gatattgcca aagcaggcct ggtcatcatt gtcggtgcca atccggcgga aggacaccca 2193721 gtgctcgcaa cacgcgtcaa acgggcacac aagctccacg gtcaaaaact gattgttgct 2193781 gacctgcgta aaaatgagat ggctgagcga tctgatctgt tcatcagccc taaacaaggc 2193841 acagaccaag tttggctgat ggctgttacg aaatatatga tcgaccaagg ctggcacgat 2193901 caggcgttta ttgatgagaa cgtcaattac tttgaagatt ataaagaaac ccttaaaacg 2193961 tatacgcttg attatgcaga acgcatcaca ggcctttcaa aagaaaacat cattcaaatt 2194021 gctgaaatga ttcgtgatgc tgacggcact tgtgtccttt ggggaatggg tgtcacacaa 2194081 aatacaggcg gttctgatac atcagcagcc atttcaaacc tgcttctcgc tacgggcaac 2194141 tatcgccgtc caggtgccgg cgcttatcct ctgcgcggac acaataacgt gcaaggcgca 2194201 tgtgatatgg gaacattgcc tggctggctg ccgggatatc agcatattac agatgacaaa 2194261 gcacgcgcta aatttgaaga ggcatatggt gtcgagattg atggaaagcc tggtttagat 2194321 aatattcaaa tgcttcatgc cattgaagaa ggaaaaatga aagctatgta tcttgtcggt 2194381 gaggatatgg cactggtcga ttcaaacgcg aaccatgtgc atgatatttt atcaagcctt 2194441 gatttcttcg tggtacagga catcttcctg tcaagaacag ctcaatatgc tgatgtcgtc 2194501 ttgccggcca ctccttcact tgaaaaagac ggaacattta ccaacacaga acgccgtgtc 2194561 cagcgattgt atcaggcgct tccgacgctt ggtgacgcaa aaccggactg gtggattatt 2194621 caagaggtgg caaaccgttt aggagcgaat tggaattaca gccatccaag tgacattttc 2194681 tctgaaatgg cgagtctttc tcctctgttt gccaaagcaa gctatgaggt gcttgaaggc 2194741 tggaacagct tcctatgggg cagcttcaca ggtgaaagca caccgcttct gtatgaagac 2194801 ggatttaatt tccctgacaa aaaagcccgc tttgcccttt ctgattggac cgagccagcg 2194861 gcatttccgg aggaatatga ccttcatatc aataacggcc ggatgctgga gcatttccac 2194921 gaaggaaaca tgacaaataa atcgaaaggc atccaagcga aagtgccgaa tgtattcgtt 2194981 gagatctcac ctgagcttgc acaagagcga ggtgtttgtg acggttcgct tgtacggctc 2195041 gtttctccgt tcggagcagt caaattgaac gcgctgatca cagaccgggt acggaaaaat 2195101 gaactctatt tgccaatgaa ctcgacagac aaggagtcag cgattaactt cttgacgggc 2195161 cctgcagctg ataaacggac gaacacgcct gcttataaac agacaaaggt ccgcatggaa 2195221 gtgcttggcg gctgtgaaac agcgccgctt ccaaaaacaa atccgcgcaa caaaaaacgg 2195281 catccgcaaa acggagtcga agcagaaaga aaatggaacc gccctggcta tgtacatctg 2195341 actgattaaa cgataggagg aaaacgaatg gccactccga ttacgacgat caaaaaagaa 2195401 acaaaaacag ctgagcaaat taagcttgaa aaaatagaag aactgaaaga gctgctggcg 2195461 gaaaatgagg acgccgtctc taaaacgatg acgttaatga atgaactcaa tgatcttgga 2195521 atttttgatg cggcaacaag catgctcaga gcgaaggaag acattgccaa gattgcgctt 2195581 ggccaagttt cccgcgagcc tgtcaccaac ctcatcaaca cgatgatggc cgccggaggc 2195641 gcattgacaa aagccgatcc tgagtttaca gcaaagcttt tagaaagcgt aatggctggg 2195701 actgaacagg cacaaagctt tttaaaagaa gacaagaaag tcgggattct cgacctgtta 2195761 aaagcaatga acgatcctga catcaacaga gccgtcgggt tcggccttca gtttttaaaa 2195821 ggcatgggaa aagaacttcg agaacaataa cagaaaaaca gccatctctg atgatggctg 2195881 tttttttatt cgtcggcttc ttccagacgc ttcttgtaaa taagtgaacg gtcagcgcaa 2195941 aagaaggcac cggctaaaaa tacgcaatcc gctaaaaaca tcgtcgattt ctggcctaat 2196001 gttaagcctt gatcagggag aactgcgcct atatataaaa aagtgctgac tgcaagcaat 2196061 gtaaaagcaa aatgcttgta gtcttctttt aaagatttca ttctattttt gttcaaaaga 2196121 atcacctgcc agattcatag tatacgacta ttataatata atccggcggc ttacagagaa 2196181 agtaattcta tccatttgtt atatattttc aagcgcttgg ccgatatctt ccaacaagtc 2196241 ttccgcatct tcaattccta cagaaattct gatcaagccg tccgtaatgc cgagctcaag 2196301 ccggcgttct ctcggaatag aggcatgtgt cattcttgca ggaacagaaa ttaagctttc 2196361 aaccgccccc aggctttcag caatggtaaa cagtttcaga tttcctaaaa acgcatcaac 2196421 ccgttcttca ctgccaatat caaaggagat catgccgccg aagcccgctc cttgcgtttt 2196481 tgcaagctca tgtccgggat gatttgaaga accagggtaa tataacgttt ggacagcagg 2196541 gtgattctca agaaagcttg cgattttccg cgcattttga tcgatcgctt ccattctgag 2196601 tcccaacgtt ttgattcctc tcattaacag ccaggaatct tgagggccga gcacgccgcc 2196661 tgtggagttt tgcacaaaat gcagctcttc tccaagctct ttcgaagctg tcacaactaa 2196721 acctccgacg acatcactgt gtccgccaag atattttgtc gcactgtgca gtacgatatc 2196781 agcgcctaaa gtaagcggct gttgaaaata aggagtatta aaggtattgt ctacgataag 2196841 cagaacaccc gctttttttg cgatatcagc catgagcgtc aggtcggtga ttttgagcaa 2196901 cgggtttgtc ggtgtttcaa tataaattgc ttttgtatta gggcgaatcg ctttttcaac 2196961 ttcttccctg ctgctcgtat caacaaatgt tgattcaatg ccaagacggt taagcacctt 2197021 tgtcatcacg cgatatgttc cgccgtacac atcatcagtc aacacgacat gatctccgct 2197081 gttaaacagc atcataaccg ctgtaatggc agccattcct gagctgaacg catagcctgc 2197141 ttccccgctt tccagttctg tcacaagtgc ttcgagagcg gttcgagtcg gattggccgt 2197201 tcttgaatac tcgtagcctg tatgctgccc tgctttcggc tgcttgtacg tgcttacttg 2197261 ataaatcggc acggaaactg cgcctgtttt ctcatcacct gtgattccgc catgtatcat 2197321 caatgttttt ttcttcatat cagatgcctc cttcgtatat ttgtttgctg atatatcgat 2197381 cgctgctgtc aggaaatact gtgacaatgt tagttccagc ggatgctttt ttcgcttcct 2197441 ccaatgccgc ataaagcgct gcacctgaag agcttccgat cagcaggcct tctttttctg 2197501 ccgcttcttt cacaagtcta aacgcattct catctgttac ggtgtagatc tcgtcaaaat 2197561 ggctcttatc catataatcg gggataaact ccatgccgat gccctctgtt ttatgagcgt 2197621 ggggctctcc tccgtttaaa atcgagccca ccggttcaac aatcaccgtt ttgactgctg 2197681 gatttttttc ttttaagaag gaagctgtcc ctgcgaatgt gcctcctgat cctgcccctg 2197741 cgacaaatgt atgaatattc ccgtcaagcg cttcccacat ttcaggtcca agcgtcttat 2197801 agtaagtcga tggatttact cggtttttaa attgcaaaac gcaataagaa ttttcaattt 2197861 cagtctccag ctgaatggct ttttgaatgg ctccctgcat tccgtcttga cgcggtgtat 2197921 gaatgattga tgcgccaagc gcttgcataa tttgctgttt ctctctgctg aaatgttcag 2197981 ggacacagaa aatcgctttc agcccatatt ttctggcact taacgcaagg ccgatccctg 2198041 tattgcctgc cgtagcttct ataatcactc cgccgggttt cactttgcct gaatcgagcg 2198101 cgtcacgaat cagcatatct cccagtctgt ctttgatgct tccccctgga ttcatcattt 2198161 caagcttggc atacaccgcg actccttctg gaacatcaaa gttcttcaag cggagaagcg 2198221 gtgtattccc aatcagctcg gtaatgtccg taatcactgt catatatgtc ctcctcctta 2198281 atagaggttg tttttagaga aaaacggagg agaacgttct ccccgtttta atgaattcgt 2198341 ttgatcacct ttaacacaag ctctgttgaa tgaacagccg cctgctctaa aaattggtca 2198401 aatgaaacat gtgattcttt gcctgcgata tctgataacg ctctgatgac gacaaacggc 2198461 gttttaaatt gatggcatac ttgagccact gccgcagcct ccatttcaac cgcgtacaga 2198521 tcagaaaatc tcgcacgcac ctcttcaacc cgcttcggat cgttcatgaa agaatcgcct 2198581 gttgcaatcg ttccttttgc aacctgaatg ccgtcgagtt cagataccgc ttcttcagtg 2198641 atgctgatca gcttttcatc cgccgcataa gcagccggaa gacccggcac ttggccgtat 2198701 tcatagtcaa aagccgttac gtctacatca tggtggcgaa cgtcagtgga aatgacgaca 2198761 tcccctacat tcaatgtatg atgaaatccg ccggctgagc ctgtgttaat gacataatca 2198821 ggcttgtaac ggtcaagcag aagcgtcgtg ctgatagcag catttacttt tccaattcct 2198881 gattttaaaa gaatcacttc agttccttca tattcgcctg ttgtaaattc acagtgtgcg 2198941 atcgtttctg tttttgcatt ttcaagtttg tttcttaaga tggtaacttc ctcttccatt 2199001 gctccgatga ctgctagtct catctattca cattcccttc actttaccgt ttgatcgcct 2199061 ccattatcca cacgaagtcg ttttgctgag tgaatcggac tgcaaaacct tcagctgtaa 2199121 acatttcttt caacgcatcc aatgtaggat aatgctctgt ctctaaatca tttgcaagct 2199181 gataaaagcc ttgagaacgg gctttatcga tagcctgttg atacgcttgc gcattttcaa 2199241 agacggtatc ggcaaacact attttatcat gcaagtgaag gtatttgcca tattgcttta 2199301 tggcagcccg cttttcttcg tcagtcaaat gatgaaaagc atatgaactg acaatcgtat 2199361 cagcctgaaa tggcggctca gggaatgtca ggaagtctcc atcaacgatt tccgtcctgc 2199421 ctgagagctt gtcagaagcc agtttacgca ttgctggaga aggttcgatt ccaaatacag 2199481 ttttgcctgc atcgagcagc ttagctgtca aattcccggt ccccgggcca aattctaaca 2199541 catgcgttcc agattttctg acgatggcat caaggatatg atcgtagcct ctgaacgctt 2199601 ctttatactg aatatctaaa ccttgtactg tttgatcata agttgctgcc caatcttcaa 2199661 agagagggat aaattcacgg cccatatttg tcacactcca tatttaataa ttcctataag 2199721 tatactatgg attaatgatg gaacagttcc tataatacca catattctga aaagcaggta 2199781 ctaaaacact ttgtgtattt tatgccatct catattgcgc attgaccgca aaaaagctta 2199841 tacttcatat gacttgtgaa agctggaggg tcaagacatg aattttcaat tagatctgat 2199901 taaagacaaa gtggaatttt ttgaagcggc ttcattgcag gagcttgaaa agaaaatcaa 2199961 tacacaaatt gaaaacaata aagccatcat gctccgggtg aaatctgttt cacaccaaac 2200021 tcttgtggca gaaggaagaa tattgtacag cgcggtggtt catttctcag ctgaagccta 2200081 aaacaaaagc agccggtttt aacccggctg cttttgttta ttttagcttt tctacttttg 2200141 tcggcttcca gcctttttca tcgacccatg taatcgtgac ttgatattta ttcccagtcg 2200201 ccttgtccaa aatcttgcct ttggcatcct gagggctgcc gttatttcca agccagagca 2200261 ccgtcatgtt atctgttgag acaccagttg cgtacgaaat ggctttcagc atctcagccc 2200321 agtcttgtga gcttgaatca taagtagcgg catgctcgcc agtctgctca gttccgactg 2200381 ctttccagtc aggattttca tacgtttttt ccacatcgct cgatgagccg ccttctgtta 2200441 cttttgcatc tttaagcccg tcaccggctg aatctgagct tgaatctgaa tcagagtcat 2200501 cttttttaga agaagaatca tcttttttgg aatcagagtc agaagacttc tcagaatcct 2200561 tttcgctgtc agatgtatct ttcttgctgt cttttatatc ctcatccgat ttcttttccg 2200621 tctttcctga agccggagat tcctgttttt gcgccgtttc agaatccttg ctgacatctt 2200681 tgctagaagg actgttaatg aagagattcg ctgctactac gacaattagt atggatacga 2200741 ttgcgattaa aatgttaagc actaaattgg cttttctgcg tttatcacga ttttcataac 2200801 gagattgatt attgctcaat aattctgcac tcctttatcc ctcttggctc agcatatatt 2200861 ttaacatgtg ctgagaagtt gttctatttc tgattgattt caatttcgtg tactttttta 2200921 acaatatcat aaaacaccga atttgtcaga gccttatctc ccggtgtatc catgtgtaaa 2200981 acaactagag cgtatttcgg cttatccgcg ggaaaatatc cggcaaacca tttttcgtag 2201041 agcgtttcct tctcttttga aagcttgcct gtctgggctg tgcccgactt ccctgctaca 2201101 gtatacggaa gatcttgaaa ccttctgccc gttccggaag gagattctac tacccgccgc 2201161 agtatttttt gaagctgctg tgacgtatat ttgtctatcg tttccccttt gagcttctga 2201221 tctttaaacg taacgagcgt tgtgccgttc ttatactcaa tttgttcggc aattttcacc 2201281 tgccgttttt ctccgccgcg ggcgattgtc gccatcatat tggctacctc cagcggcgtt 2201341 acctttacat ttttctgccc gattgctgtt tgcgcaatgg cttttttgac tgatttgtct 2201401 ttttcatccc cccaaatcac gccgcttttt tcgttataca gctggcggaa atcggtttcg 2201461 tggtacagtt ttccctccca gcctgcccga tcagtgagag ccagcttctc ggacatatct 2201521 tcaataaccg agctgtcttt tttcattaat tgttctgcaa gactcgtaaa tgtgtaatta 2201581 cagctttggg caaaactttc atcaaaagac aaggtgcctt tgtcgtcccc cggttccccg 2201641 tacaggttta aattgcaatt aaaggtttga ctaggcttca ccatattatt ttcgattgca 2201701 gctgcggcaa tgactgtttt aaaaactgat ccgggataga ttggcgtcag catataattt 2201761 tgaagtgtgt tttgccggga cacgtctgca tctggtttgc ttacaattcc cagaacactg 2201821 ctattttcga tgtccagcag cacagctcct ccctttttca gcccctgttc atccaatacc 2201881 tcctccatcg ctttttgaat gctttgatcg atcgttgttt tgatctggag cggataaaat 2201941 gtattggctt cagctgtata tttgacgtcc atgccaaaca aagggtttcc ttttccgtcc 2202001 acatgatata aaagctttgt gtcttgttcc ggaagcaaaa actcgtcaaa tgtccgttct 2202061 aaaccggttg ttccgatttc tgttgtaatc ggaaggctct ccttgtcagg atatttcttg 2202121 cgaagcagcg ccggatcttg gttcgtgctc cctatcgtat gtgaagcaag gctgggcttg 2202181 tcttcattct ccatatatac gccgtaaatg ccgggatatt tcaaagaatt gatttttgtg 2202241 atagattgtt ttgaaagtgt tttgattttc ttttgctgca aaatgaccgg tttttttgcc 2202301 tgacctagtg tctggcgcaa atcatcttca gacatgccga ggatgtccgc aacttttttg 2202361 atcggccaat cctgcgtcag cagaaaaggg aacaaaacaa ccgcaggctc gctttgtcct 2202421 gtcagcgccc gcccgtttcg atctaaaaaa gagcctcttc catctgaaat gagcacttcc 2202481 tccgtccgct gtttcacact ttcttgaatc aaattaattt tctttttaga aaatgattct 2202541 gtgaaaaaca gctggatttc tgcaagtctc agcagaagca gaaaaaatac aatcaaaaaa 2202601 gcgatgactg ccagcttcat tcgtttcgat atcttcataa aaaaacacct cacccacatt 2202661 gtggacgagg tgtttcgctg ctaaacagat attatgaaat tttcacaatt ttcacgagca 2202721 tttctccgcc cggtgtttgt actgtgactt cttcatctac ttttttgccc aagaggcttt 2202781 ttgcgatcgg tgaatcgttt gagattttcc cttcaaacgg gtcagcttcc gcgcttccga 2202841 cgatcgtata tgattcttca tcaccgtcag gcagttcgac gaaagtgacg gttttaccca 2202901 aaccgacaac gttagagccg ccgtcatctt caatgatttt cgcattgcga atcatatttt 2202961 caagagtcgt cacgcggccc tctacaaatg cctgctcttc tttcgctgaa tcgtattcag 2203021 agttctcgga aaggtctccg aagcttctcg caattttgat tcgctctact acttcttttc 2203081 gtttaaccgt tttcaaatat tctaattctt gttcaagttt ttgttttcct tctgcagtca 2203141 taggaaaaac tttctcttgt gccatgtccc ttcactcctt ctggttgtcc ctcaacatct 2203201 tcgattatgt atgagagcat aaactaaaaa atacaagaat gagaacacag ggcagtcctc 2203261 gttcttctct cccatatagg tactgtttat cttaaactga atcgtgtcgt tctgcaaata 2203321 tttcgcgttt ataaacaggg aaagaaggga attcgcacat tcccttcctg cctatacata 2203381 atatggtcag agttatttat gtctatgcta tggtattaca aaatcgcgtt ttgttcaaga 2203441 atggtttgaa tttttgtgac catcagatca attgcgacgt gattctgacc gccttccggg 2203501 ataataatat cagcgtatcg tttcgtcggc tcgacgaatt ggttatgcat cggacggacc 2203561 actgacacat attgttcaat gacagaatca atagagcgtc cgcgctcatt aatatctctc 2203621 ataatccgtc tgatgatacg caagtcagcg tccgtatcaa cataaagctt gatatccatc 2203681 agatcacgaa gccttttgtc ttcaagaaca agaatgcctt caaggataat aacatccttt 2203741 ggctctacgt gaaccgtttc ttctgaacgt gtgtgaagct tatagtcata aatcggcttt 2203801 tcaatcgggc ggtaattcaa tagatcttga atatgctcga ttaaatagtc attatcaaac 2203861 gcaagcggat gatcatagtt tgtgttcagc ctttcttcaa acggaagatg gctttggtct 2203921 ttataataaa ggtcctgctg gatcattaaa attgagtgtc ctttaaactg ttcataaatg 2203981 gaccgtgtga cactcgtttt tcctgaaccg gaacctcctg cgattccaat gactactgga 2204041 ttcttaccca tgggctgtta cttccccttt ctcatcatgt tgctcggata aatctttttg 2204101 tctagtttga atttgacaat ttgcagggga tggcgggcag catctagctc atttccgtct 2204161 tcgtcccaaa tggtttcaat cgtatgtgta aagttttcga tttctggacc gaaaaattcc 2204221 acttcgtcgc cttttttgaa gaaattgcgc tgctgaagcg tgaccatttg tgtatcttca 2204281 tcataattca gcactaagcc gacaaaatca tatgtcgttt tcttggcgtg ttcgccgaac 2204341 atttgctctt catagcctgg cgttccttca aagaaagctg tcgcagtgtc cctgttggcg 2204401 cacttatcaa gctcttcaag ccattctttt tgaatcacaa agttttctgg atcagcgcaa 2204461 taagcatcga ttactttgcg gtatacgctg acaacagttg ctacatagtg aatggatttc 2204521 atgcggcctt caatctttaa gctgtcgatc cccatttcaa tcatttttgg aatggattca 2204581 atcagcttca aatctttcgg gctcatcgca aatggtgcat cttcttcacc atacaaagca 2204641 acggcgttgg caccgtctgt ttggtagaga tcataatccc agcggcatga ctggcagcag 2204701 cctccgcggt tggaatcccg cgctgtcatg tgattgctca gcacgcagcg gccggaatat 2204761 gcaatacaca ttgcgccatg aatgaaggat tcgatttcga tatctacctt ttctttcatt 2204821 tctctgattt caagagcgct agtttcacgt gccagcacga cgcggtcgag accttcttcc 2204881 ttccagaact ggacagcctt ccagtttgaa agagactgct gtgtgctcaa gtgaacctca 2204941 acattcggcg ccactctgcg gcatgtttca ataataagcg gatctgccac aataataccg 2205001 gcaacgttgg cgtctccaag cgcttttaaa tagtcttcaa gcccgtccat gttttcatta 2205061 tgagcgaaaa tattcgttgt tacgtagatc ttcgcgccat atttctttgc gaattcaacg 2205121 ccttctgcaa tttcttcgat cgtaaagtta tcggcattcg agcgaagccc gtattcctgt 2205181 cccccgataa agaccgcgtc cgctccgtaa tgaacagcga ttttcagctt ttcaagatta 2205241 cccgcaggtg cgagaagctc cggctttttc gtaatcacac gctttccatt aacgattgtg 2205301 gatattttat catttacggc agtcatagct taacctcctt ttgattaata aaccgtttcc 2205361 ttgaagaaga atccggtatc aatttttctg tttactggct ggatgctttc aatgcgttcg 2205421 atccagtctt cttttttcgc ttcgtattcg tcacggtttt ccacgcacaa atcaattgct 2205481 tctctgtaca ttttggtgac ttctattagg tattcaggca ttttcaaaac accatcgatt 2205541 ttgaaagaat caattccggc atctatcaat tcctcgagct catcaatgat gcacacatcg 2205601 ttcgggctca tgatgtgagt gccgttttca tcttcgaaaa tcggatattt attatcgcgt 2205661 tctttatcgt gtaaaaacat gcctgattct tttttctttc tttcaatgtc catgactttg 2205721 ccctgatatt caaaatagtt tccaatcaaa gaacgcttcg attggaacat gcacgtcatt 2205781 ccatgcacct ggatttcaat ttcgacttca gcattttctt taatctcaac aatgctgtcc 2205841 atgtttaatt ctctggcaag cacagaacgc gccgcaccct tgcgtcccca gtagttgcat 2205901 gtataatagt tggtgcctgt cgtttctgtg ctccaatgaa gcttcagatc aggcgcagat 2205961 tcacgggcag ccatcagcac ggcaggatcg ccgaataccg ctgcatcgac accggcttct 2206021 gctaagaaag ccagatattc gccaagctca cccactttat cattatggaa aattgcattt 2206081 acagcaacgt atacttttgc cccttctttg tgagcaatct ctacggcttt tgttacatct 2206141 tcacgagaaa attctccggc taatctcaag ccgtatctct gttccccaac taaaaacgca 2206201 gttgccccag cctgtatgag cggcaaaatg tccgctgtac tcgtcggcgt cactaagagc 2206261 tctggttttt tcatgacgtt cacctcttct ttttactaat cgcaagtccg tccccgacag 2206321 gaataatcgc agtttgataa tccggatgat tcatcagcca atgattatat tcatcaattt 2206381 tggctacaag cctgcgcctt ctcttcggtt ctattttgct gtaatcctct gccaccagac 2206441 ctttaaacag cacgttgtct gttataatca ccccgtccgg tgaaagcatc ggttcatata 2206501 aatgaaaaaa gttttgatac tgaccttttg cagcgtcaat aaaaatgaca tcgtaaggcg 2206561 cggttacatg aacggcgtcg gctaattcaa gcgcatctcc gtaaaaaaca tgaatccggt 2206621 catcaagctg aaattccttg atattgttta ccgcttcttc atgccgtttc tcattgcgtt 2206681 caattgtata tatttcagca gacggcagtt ccagagccat tcgaatggct gaataaccaa 2206741 tggccgttcc gatttctagt atttttttcg gctgtttcac agacaaaatt tgaagcagca 2206801 cctccatgcc cgctttttcc ataatcggga catgatgttc ttctgcatat gcttcaagtc 2206861 tcttcacgtt atccggccga ggctttaata atgcttctat atagtcattt atttgttcat 2206921 accggtcagt cactacaaac agcctcccgt tctaaaaagg agtgccccag tcttatgcgc 2206981 aggacactct ctgaatacat catgatacat cggtaaacaa cccgatatat tttatcataa 2207041 aaccttgcgg aaagcgaaca aaaggagagc tttttgctct ccttttattt ctcatttttt 2207101 gaggaaatgt atttttcttt tgctttatta tgctctttta gcgtttttgt aaatacgacc 2207161 tcaccatttg atttggccaa gaaatacaga tagtccgttt tatccggatg cagcgctgct 2207221 tcccatgatg acatgccggc attggcaatc ggccctggcg tcagccctgt gtttttatac 2207281 gtattgtatg gtgaatcgat ttccagatcc ttataaagaa cccgatcttt atgcttgcct 2207341 gccgcgtaca ggacggtcgg atctgtttgg agcggcattt tctttttcag gcggttataa 2207401 aagacgctcg caattttatg gcggtcggct ttttcagtcg cttcttcttc tatcaaagaa 2207461 gccattgtca gcagcttatg cacagaaact ttgtttttct tcatttctga tttatatgtt 2207521 tccacataag aatttgtctg cttaatcatt gccttgataa tgtcttcaag tgatgtgtcc 2207581 ggatcgttaa aagggtatgt agccgggaat aggtaccctt caagcgggtg cttaatgttt 2207641 ttattgaaaa catcatttgt cacagtgtcc gggaattctt tcttcagctg attgataaat 2207701 gtttcatcgt ccagcttcgc tatgacttgt tttttagagt attttgtttc atcagcaata 2207761 gcagccgcga tttgggtcag ctgtgctccc tcagtcactg tgatttgaaa agcgtaacct 2207821 gtagccccgc ttgtcagctt ctgaataatg gcatctaaat ccataccttt attcagatgg 2207881 tagaatccgg cctgaaaccc ggaagcacct ttatatttca catagtactg aaacgccttc 2207941 tcgcttttta tgacatcatt tttctttaat atcgatgcga tggctgaaac agacgaaccg 2208001 ctcggaatgt taatattaac tgtcgtttta ctgtcttttt caacaggttc aagcaatgat 2208061 ttcccatata aaaatgcccc gccaatgatg agaaacagca caacaatgga agacagtatg 2208121 attctttttt tattaaaaaa cgattttttt tgctgattga tatacattag gtctcctccc 2208181 atcagctctt atactacatg attcattgta tttcggcaat ttattacaaa aagaggcctg 2208241 cataaagcag aaaaaagccg gagcagtata gctccggctt tggtttggcg cgatgtttta 2208301 ctcttcgtct tcgtccgcta agaatgtgtt tagtgtttct tcgatcatat cccattcttc 2208361 gtcagtttca atcgggaata gctcaccgtt ttcaccgtct tcgtttggcg tgaagctgga 2208421 agcaagaatt tctacttctt cgtcatcttt tgattcgatt ggatagtaca agacataaga 2208481 tttgccaaac tcttcatttt caaatgtaaa cagcacttca caaagctgtt catttccttg 2208541 atcgtcaaca attgtaatat ttttttcgcc gtgttccatt ttcttcacct ctggctttaa 2208601 tttaagctgt caagatatcc ttgtaaaatc ataacagccg ccattttatc aatgactttt 2208661 tttcgttttt gcctgctgac gtcagctgca atcagcattt tttcagccgc cattgtggta 2208721 agacgctcgt cccacagcac aacaggaaca ttgtacgttg tttcaagcac tttcgcaaat 2208781 gtttggctgg cttcgcctct cgggccgact gttccgttca tgttcttagg aaagccgagc 2208841 acgattttat ctatagtata gtcctttatc agttcagata aacgggataa accataatcg 2208901 ccttctgctt catttatctt tatggtctca atgccttgag cagtccagcc catttcatcg 2208961 ctcagagcta caccgagtgt tttggttcct aaatcgagtc ctaatattct cattctttat 2209021 ttacgcctct ttatgctgtt ctaaataaga ctttaccaat tcctcgatta attcgtctct 2209081 ttcaagtttg cgaattaaat tgcgagcgtc acgatgccta ggaatataag cgggatcacc 2209141 tgacagcaag tatccgacaa tctggttgat tggattgtag cccttttcct gaagcgcgtc 2209201 atacactgta atcagcacct catttacgtt agtctcagca gaatcatcgg agaaattaaa 2209261 tttcatcgtt ttatcaaacg agctcaccgt tttgcacctc tttcccaaat tcgcaggcaa 2209321 agttcagcct ggggtcctaa tcttaccatc attctacact acatgggcga attataaaac 2209381 ggatttcacc caatcttcta cagaagccaa agcttcttct aatttttccg gctgtttacc 2209441 gcctgcctgc gccatgtccg gacggcctcc gccgcctccg ccgcaaactt ccgcagcttg 2209501 tttaaccagc ttgccggcgt gaagtccttt ctcaatgagg tcctttgtga ctccggcaga 2209561 gatattaact ttatcgtttt gtaccgcacc aagcacgatc accgcagagc caagctttgc 2209621 tttgagttca tcgaccatag tgcggagatg attcatgtct tttgcattta cttttgccgc 2209681 aagcacgttt acgccgtcaa cttcttttac tttcgacagg attgctcctg cttccacgtt 2209741 gcctagtttt gcaagaagag attcattttc tctttgtgca tccttcagtt cagcctgcag 2209801 agccgcgacc cgtttcggca cttctttgat atttgttttc agctcgtcag cggtctgctt 2209861 caatacagaa atctggctgt tcatttcgac gtaagcgcct tgtcccgtta cagcttcaat 2209921 ccgtcttgtg cctgctccga ttccggattc agaaacgatt ttaaacaagc cgatttctgc 2209981 tgtatttctg acgtggcagc cgccgcacag ctctaagctg taatctccaa cttgaacgac 2210041 acggacaata tcgccatatt tttcgccgaa cagtgccatc gcacccattt cttttgcttc 2210101 agcgatcggt ttcaaatcaa tgctgaccgg gatgctcgcc cagatctttt cgtttacgat 2210161 tctttcaatt tgttcgagct cttcttttgt cacttggcca aagtgcgaga agtcaaaacg 2210221 aaggcggttt tccgttacaa gagagcccgc ctgattgaca tgagttccaa gaacatcttt 2210281 tagagcctga tgcaataaat gcgttgccgt gtggttttta atgacgccgc ttctcatatg 2210341 gtcttcaact tcagccgtaa catgcaggcc tttttgaaca gtaccgctct ccacaacacc 2210401 ttcatgcaca tgctggccgt tcggcgcttt ttgaacatct ttaattctta caactgcctg 2210461 ctcgcttcgg agatagcctt tgtcgccgat ttggccgccg ctttctgcat agaacggtgt 2210521 ttcatcaaga atgatttgaa cgctttctcc ttcatgagcc tcttcgatta attggccgtc 2210581 ctgaagaagc acaatgatat tggcatcagc tttggtttga gagtagccga caaatgtgct 2210641 ttcaactgtc acgtcgcgca gtgcgccgcc ctgcacctgc atgctgccga catcctggcg 2210701 ggcgtttctt gcccgttcac gctgctggtt catttcctcc tcaaagccct catggtcaac 2210761 cgtcatgttc tcgtcttctg cgtattcttc agtcaattca accgggaatc catacgtatc 2210821 atacagttta aacacatcag cacctgagat aacgctgctg cccttgtctt tttctttttt 2210881 gatcatttct gacaggatcg caagcccttc attaagggtc tcatggaagc gttcttcctc 2210941 ggttttaatg acttttgcga tgaaatccgc tttctctttc acttcaggat agaaatcagc 2211001 catgatttct gcgacaaccg gcactaaatc aaacatgaac ggacgatgga tgttgatcgt 2211061 tttggcataa cgcacggcac ggcgtaataa gcgtcttaat acatagccgc ggccttcatt 2211121 tgacggcagc gcaccgtcac tgacagcaaa ggcaaccgtt ctgatatggt cagcaatcac 2211181 tttaaacgca gtgtctttca cattgtcttt gccatatgtt tcaccagaaa tcgattctgt 2211241 tgctttaatg atcggaacaa acaaatcggt gtcaaagttt gtcggaacat tctggatgac 2211301 agacaccatt ctttcaagac ccatgcctgt atcaatattt ttctttggaa gcggtgtgta 2211361 cgtgccgtca gggttatggt tgaactctga gaacacaagg ttccatactt ccaggtaacg 2211421 gtcgttttcc ccgcctgggt aaagctccgg atcttctgga tcattaccgt atgcttcacc 2211481 gcggtcgtaa aagatttccg tattcggtcc gctcggccct tcaccgatat cccagaagtt 2211541 cccttccaga cggataattc tttcttcagg aataccgatt tttttcgccc aaaactcata 2211601 tgcctcttca tcttcaggat gaaccgtaac agagagaagc tctttgtcga agccaatcca 2211661 cttgtcgctc gttaaaaact cccaagccca tgtaatggct tcttctttga aataatcgcc 2211721 gatggaaaag tttccgagca tttcaaagaa agtgtgatgg cgcgcagttt tacctacatt 2211781 ttctatatcg tttgttctga tcgctttttg agcgtttacg attcttggat tttccggcac 2211841 gacacggccg tcaaaatatt ttttcagcgt cgcaacaccg ctgttgatcc aaagcagtga 2211901 aggatcctca tgaggcacta atgacgcgct tggctctacc gcatgtcctt tttctttaaa 2211961 gaaatccaaa aacatttgac gcacttccgc agaagttaag tgtttcattg tatttcctcc 2212021 tctataaaaa tcgaaattct cttcagtgac agcaaaaaag ccctccccct atgcaaacca 2212081 acgtttacac agggacgaga gctgtctcgc ggtaccaccc tgattacggg cattcatgcg 2212141 cccgtcacct ttaaccctgt aacgcaggat aagcggcagt gattaactgc actcaggatt 2212201 agcttcctcc gatcttctga taaagctcct ttcagcttat ggagcttctc tctttaacag 2212261 ggcttcggcg tactcagatc cgtcactcga gattcgtatg tattctacga gaaattatag 2212321 acaagcggca cgccgatgtc aatgctccgt cctcatccgc aaaaaatgga tcatcattac 2212381 ttttaaaaca gccgtcgcag gaacagccag aatcatcccg acgatacccg caagctcccc 2212441 tccggcaagg agtgcaagca tgataacgac cggatgcatt ttaaggcttc tgccgacaat 2212501 gaacggactg aggatatttc cttccataaa ctgcagaata aacaccgtaa tcaccacaac 2212561 aagaaccgcc ttgactgaga tcgtcatcgc aattaacaac gcaggaacag ctccgatgaa 2212621 agggccaaaa tacgggatga cattcgttac cccagagata aggccaagta tcagcggata 2212681 cggaagccca aatacccaga acgaaatgcc tgcaatcacg ccaagaatca agcagaccaa 2212741 aagctggccg cggatataat cgccaagcga atcatccaca tcccgcaaaa aggcgctgcc 2212801 ccgctttctc cacgacttcg gagtcaagta ccatactgtc tttttcatta actcaatgtc 2212861 cttcaccata taaaacacga gaaaagggat tgttgcagca attaagaagt aatcaagcac 2212921 attgcggatc ccgctgatcg caccctcgat cgttcccgca aaaaacgcct ccgtctggcg 2212981 gatcatttta tctatacggt gatgcatacc atcaggccag tcatccgtat ggttatgcac 2213041 atgaagaaga agcccgttat acgtttcggc aaacatgggt atattttctg acaaatccgt 2213101 cagctgcacg attaaaacag gcaccccttt atacaacgcc cagccaatcc cgccaaaaaa 2213161 aagaacataa atgaccaaga tgctcaaagt cctaggcaat cctttgccat gcagccattc 2213221 tgtgaccgga agcaataaat aagatataaa aatagaaatg atcaagggaa taaagatcgt 2213281 ttttatgacg agccaaaagg gtgaccataa catatcaagc ataaaaaaga catagactgt 2213341 taacagaacc agcaaacaaa tagccaccca caacaaaagc tgcaccggtt tttggagcat 2213401 ctgctttcac ctcacctata tcttttgagg tttacaagga attattcttt atgtttcttt 2213461 agtcagtcag aagtcatgga cattttttca cttttaattt tcagaaaagt ttgatcattt 2213521 actttttggt caaattttct gataggagga ttgcgatgat cacatttcaa aatgtaaaca 2213581 agcattacgg agattttcac gtgttaaaac aaattaatct tcaaatcgaa aaaggtgaag 2213641 tcgttgttat catcggccca tccggttccg gtaaaagcac attgctcaga tgcatcaaca 2213701 gacttgagtc gatcaatgag ggagtgctta cagtaaacgg caccgccatt aacgacagaa 2213761 aaactgatat caatcaagtg cggcaaaata tcgggatggt gtttcagcac tttcatttat 2213821 atccgcataa aacagtgctg cagaacatca tgctggctcc ggtaaaagtg cttagacaat 2213881 cacctgaaca agcaaaggaa acggcgcggt actatcttga aaaagtcggc atcccagaca 2213941 aggctgacgc ctatccttcc cagctttccg gcgggcagca gcagcgtgtt gccatcgcaa 2214001 gaggactggc gatgaagccg gaggtcatgc tgtttgacga gccgacatca gcacttgatc 2214061 ctgaaatgat cggtgaggtg ctagatgtca tgaaaacact cgccaaagaa ggcatgacaa 2214121 tggttgtcgt gacacacgaa atggggtttg ccaaagaagt tgccgaccgg attgtcttca 2214181 ttgacgaagg aaaaatttta gaagaagcag tgccggctga attttacgcg aacccgaagg 2214241 aagaacgggc ccgcttattc ttaagccgta ttttaaatca ttaaaacaga aatgggggag 2214301 cttgtatgaa aaagattttt tctttagcat tgatttcttt attcgctgtc atcttgcttg 2214361 ccgcttgcgg cagcaaggga tcaaacggag aagcctcaaa ggagagcaaa aaagatacgc 2214421 tagccgccat taaagacaat gacaaaattg tcttcggcgt aaaaacggac actcgactgt 2214481 tcggtcttaa aaatccaagc tcaggtgaga ttgagggttt tgatattgat attgctaaac 2214541 aaatcgctaa agacatttta ggtgatgaga aaaaagctca atttaaagag gtcacctcaa 2214601 aaacaaggat tcctatgctg caaaacgggg atatcgacgc cattgtcgcc acaatgacga 2214661 tcactgaaga acgaaaaaag gaagttgact tttctgatgt ctatttcgag gccgggcaat 2214721 cgcttctcgt gaaaaaaggc agcaaaatca agagtgtcga gaatcttggc aaaggctcaa 2214781 aagttcttgc agtaaaaggc tccacctcct ctcaaaacat tcgtgaaaag gcgcctgaag 2214841 catctgtttt agaatttgaa aactacgcag aagcctttac agcccttaaa tcggggcaag 2214901 gcgatgccct caccacagat aatgcaattt tatatggaat ggctgatgaa aataaaaatt 2214961 atcaattaac aggaaagcct tttacagatg agccttacgg gatcgccgtg aaaaaagggc 2215021 aatctgctct cgcgaaagaa atcaacgctt cacttaaaaa gatgaagtcg gatggcagat 2215081 acgatgaaat ttataaaaaa tggatcaaag aagacccagc tgaataacaa ccatcccggg 2215141 atgagcaggc gatgctcatc ccaatttgat aaggagtgaa taggcagatg aatgtgtcaa 2215201 ttcttttcga taacttcagc atgtatatgg acggttttta ccataccttg ctcgcaagtg 2215261 ttatcgcgct ggccggcagt tttgtcctcg gcgttgctgt agcggttatg agaataacag 2215321 tctttaagcc gctgcaatgg ctcgggaccg catatgtaga attcatccgc aacatccctc 2215381 ttcttttaat tacctttgtt ttctatttcg gacttccaaa cgcaggcctg aggcttgacg 2215441 gttttcaagc gggaacggtt gctctcacca tttatacctc tgcgtttatc gctgaagcca 2215501 tcagagcagg catccagtct gtttcaaaag ggcagatgga agcggcacgc tcgtcaggct 2215561 ttacctacag ccaagccatg ctccatatca ttttgccgca ggcaatcaaa atcgtcattc 2215621 cgcctttagg caatcaattt ttaaacttag tcaaaaactc ttcgattctt ggggttgtgg 2215681 ccggattgga tcttatgtac caagccgatt tagtttcgtc gagcacactc gttgtatttg 2215741 atgtttatat ttttgtggcg cttttttact tagtgctgac gattccgctt agcatcggtg 2215801 ttaactatct ggaaaaacgg ctggaaaaaa gctattgata aggagtgagt tacattggat 2215861 ttcatcggtg cttattcaca ggagcattta gcgtttttat gggatggctt tctcgtcacc 2215921 ttgtacgttg ctttcatctc catcattctg agctttttct tcggtttaat cgcaggcacc 2215981 ctgcgttatg cgaaagttcc cgttctttct caattgattg cagttctcgt tgaaacgatc 2216041 agaaacctcc ccttgctgtt aattattttc tttacgtttt ttgcccttcc ggaaattggg 2216101 attaagcttg aaattacagc tgctgcaatt acagcactaa cgatttttga atccgctatg 2216161 ctatctgaaa ttatccgaag cggactgaaa tcaattgaca aaggacaaat tgaagcggcg 2216221 cgctcctccg ggctgagcta tacacagacc ctgttcttta tcgttatgcc gcaagcgctt 2216281 cgccgcatgg ttccgcccat cgtaagccag tttatttctt tattaaaaga tacatcgctc 2216341 gctgttgtga tcgccctgcc tgaactgatt cacaacgcgc aaattattaa cggccaaagc 2216401 gctgacggca gttatttttt cccgatcttt ttacttgcgg cccttatgta tttcgcagtc 2216461 aactacagcc tttcactcgc agcaagacgc ctcgaggtcc ggcaaacata gaaaaggata 2216521 ctctttggag agtatccttt ttgcattaaa acattttcgt aattcttctt ctcatccgct 2216581 tcatgcttcg attattcagc atgtcagatt gagtcgccat tcggtacacg agagctccgg 2216641 ctcccattgc caaaagagaa gtcatcgtcc gattcatcct gcgcatctcc tttcatgatt 2216701 aaaaattgat gctgcgttca tcctcagaaa acaaatcatc caagctgctt aacgttccgt 2216761 cttcttccac ctgatgagtt gcaatcttcc ctttcgccac tgtcagttca ataaaacagc 2216821 cccagcaata atattggttc acgccgattt tgccgatatc cttacttttg caattcgggc 2216881 atataagcat acctcacacc tctatccgtt cagaacgatc tcgtctttcc gcacctcgac 2216941 aagcgaatcc gctctttgga tctggcgctt gcttcccgcc aggtcagaaa agaaaccgtc 2217001 cgagagttca tatgctacga ttatgcccct gtccaaacaa aagtatacat cttccagcat 2217061 ccccaatata tccccctctt gcgatttcac aagcttcatc ttcatctgct cgtatgtgaa 2217121 gcatgatttc ggaagaggca aaagctgttc tgaactgacc gaagccaata tgcggtcatc 2217181 aaaaatggaa gagatatcac acgcccgtaa tagcgcatga tgatgatgca aaaagcgttt 2217241 ttgtgcaaga ataaacccaa gacaatctcc tttcagagaa aaacaaatat cggaaattgt 2217301 cccgagataa ctagaagttc gttctgagta tactgggaat ccttctactt catggcatgt 2217361 tctcaaagtg tgatcaacca ccttttgttg aacaggctta ggttttgctt tgcgccttag 2217421 actcatacga tgaaatcaat tccactgcaa atgaaaaaaa actcccgctt gcacgggagc 2217481 attttattgc tgttcttctt tcataaaatc gaatggtgta atgccttcca tgccaatgtt 2217541 ggcgtcgtgt acgctgaacg ggagctcttt ttgcaaagct tcaagctcgg catccatttc 2217601 ctcaacctgt acggacagcc tgtttttcaa ggaggtctgt ctgacagttg catcattatt 2217661 tttcacgccc cactccagcg cctcctcttc cccgcataaa atgagaaatt tcttcgctct 2217721 tgtaatcgcg gtataaagaa ggtttcttct gagcattcta taatagcctt tcacaacagg 2217781 caaaaccaca atcggaaatt cacttccctg cgatttatga atagaacagc aatacgcatg 2217841 ggtaaattga ttaaaatctt ttttcgtaaa tgtcatttca ttgccgtcaa aagaaacgac 2217901 ggccatgtct tctttttctg tattttcctt tgcataaaat atcgacgtga tttcgccaat 2217961 atctccgttg aacacattgt tttccggctg attgacaagc tgcaaaattt tatctccggt 2218021 tctgtagaca acatccccga acttcaattc tctccgtttt tctttaggag gatttaaaat 2218081 gtcctgcagc atcacattca attcattaat gccggctttt cctctgtaca tcggagcgag 2218141 gacctgaatg tcctttgctg tatagccttt tttcaatgca ttggcgacaa ccttctcaac 2218201 tacttctttg atttgcgacc cgccgcagcg aataaaggaa cggtcctttg tcggggcagt 2218261 caaattgttc ggcagcaatc catttttcat ctggtgggca agctcgacga ttgatgaccc 2218321 ttctgcctgg cgatagatgt ctgtcagtct cacagtcgga atcacctggg atgccagcag 2218381 gtctctgagc acttgtcccg gaccgacgga aggcagctgg tcttcgtctc cgacaatgat 2218441 gatttgtata tgatcaggga tcgccttgaa caaatgattc gccagccata tatcaagcat 2218501 actggcttca tcgataatta acagcttccc ttcgatcggc tgatcctctg tatgagtaaa 2218561 gccttcagcg ccgttccagc caagcagcct gtgtatcgta actgcaggga gtcccgttga 2218621 ttcactcatc cgttttgctg ctctccctgt cggagcggcc aaaacaatcg gaaaagcttc 2218681 atccttttta taagctgacg ggtctagtga cacaccgtga agctctccgt agagctcgac 2218741 aatccctctg attaccgtcg tttttcctgt tcccgggccg cctgttaaaa gaagcatcgg 2218801 cgaggaaagg gctttttgaa tcgcttcctt ctggctgggg gcatactgaa cgtccatccg 2218861 ttcttccagt tctcccaacg cgagcaaaaa ctctgattcg ggaaactggt tctcatattc 2218921 ggtttggcta gcgatatgtt tcacacgctt tgcaacgttt tgttctgcgt aaaacagcga 2218981 aggaaaataa cagcggccat cttctatgac aatgtcttta ttttctccaa gggcaataat 2219041 tgcgttagcg gcatccattt ctgtaatgcg ctgcccttcc cttgctgact ggtttaacag 2219101 tgattgagtg tcgatgatca gctgttccgt ttctatgtac gtgtgcccct ctgacagaca 2219161 agtcgtttca agcgtgtaca aaatagcagc ttttacccgc tcaggatgat tacccgaaag 2219221 acccattctg ctgcccagct catccgcttt tccaaacccg atgccttcta catccttcac 2219281 aagctgataa ggattttcct gaatcttttc aagcgtctcg gattcatagg cttgatagat 2219341 tttcatagac agctgcgggc caaagccaaa ctgattcaag gaaatcatga tttgctccag 2219401 tccctgatgc cgctgcaatg cgccagccag cgtgtctgct ttcttttttg agagtctggg 2219461 aacatcataa agcactgaag catcagccaa tattttatta atggcgctgt cgcccagctt 2219521 tttcacaatt tcttcagctg tttttttgcc gatcccctcg aataaatcac tcgataaata 2219581 ttgaatgatg ccttccttag tcgttggaat ctcctttttg aaatgctccg cctgaaattg 2219641 gagcccgaat tttggatggg ttacgatctt tccgtaaaac gtgtaggtct cttcttcttg 2219701 aagcgcaggg aagtagcccg tcacggatac ggctttatct tcaatggctt cggaggtctc 2219761 tgtgactttc actttcagaa ccgtatataa attggtgtca ttatgataga tgactgtgtt 2219821 gactgtccct tttaaatagg gctcttcctc cagtttaagc tgatccggat gctgctgcac 2219881 gagctgtccc tcctcctgtg cctgttatga tggatcaatc agttttttag catgaagcgc 2219941 aagcatatga tctggctgga tatcgattgc cttgtccagc atttccagcg ctttttctcg 2220001 gttttcttta taagcataag tgacaccggc attataaaat gcatctgcat gccccgggtc 2220061 ttgctctgtc acagctgcga attggctgag cgcttcgtcc agcatgccct cgttggctaa 2220121 gcacatcccg aattgaaaac gcgcttccgt atcgttttca ttcagttcga ctgctctttg 2220181 taaatatggc agtgcaagct taggctgttc gagcttgaca agtaccgttc cgagcatgta 2220241 aaacaggtcg ccgttttcca tccccgcacg tagcgctttt tcaaacatgt ctttcgcttc 2220301 tttgtacatt tcttttacaa catagacatt tcctgctcca taataagcag tggctgcgct 2220361 actgtctaat tcaagcgctt tatcataaaa cgcaagcgca cgttccagct cgtttacgga 2220421 tgaaagaagg ttggcaaaat tgatatacgg aatcgcgtct tctttatttt cttcaatcgc 2220481 ttttgtaaat gcctctgccg ctttctcgta atcgccttcc tgcatcgcct ctataccgag 2220541 ttgattataa tccaccgatc atcttccttt cattaaaaaa ccccaactca gtgttgaggt 2220601 ttttcatctt ttatacgtac cacaattttg ttccgtcttt gtacacatca tcaattgtcc 2220661 cgccgccaag gcattcttcg ccgtcataga agacaacggc ttgtcccggc gttacagcgc 2220721 ggacttgttc atcaaagatg acttccgctt caccttcgcc agtcatgcgc actgttactt 2220781 tatgatcctc ttggcggtaa cggaatttag ccgtgcagga aatctcttcg cccttcatga 2220841 tatccgaacg tacccagctg atatttgttg ctgtgatttt gtcggaatat aaaagcgggt 2220901 tatggaaccc ttgatctacg tagaggatgt tcttttcaag atctttgcct accgcaaacc 2220961 acggctcgcc gcttccgccg atgccaaggc cgtgacgctg tccgatcgta tagtacatca 2221021 acccgtcgtg gcggcctttt acttcgccgt ccatcgtcat catatcgccc ggctgtgcag 2221081 ggagatattg gctgagaaac gttttgaagt tgcgttcgcc gataaagcag atgcctgtac 2221141 tgtctttttt cgtcgctgtt gcaagttctg cttctttggc aatttcacgc acacggcttt 2221201 tttgaagttc gccgatcggg aacatgactt tgctcagcgt atcttctgtc agctgattca 2221261 ggaagtacgt ttgatccttg ttttcatcaa tgccgcgcag cattctgact tttccgccgc 2221321 ttctgtctac tcttgcatag tggccagtcg ctaaatagtc ggcgccaagt gacaatgcat 2221381 gctccaaaaa ggccttgaat ttaatttctt tgttgcacaa tacatccggg tttggtgttc 2221441 tgcctgcttt atattcatca aggaagtatt gaaatacctt ctcataatat tgcttttcaa 2221501 agtttacggc ataatacgga attccgattt ggttgcagac gcggatcaca tcttcataat 2221561 cctctgtcgc cgtgcaaaaa ccgttttcgt ccgtatcatc ccagtttttc ataaagattc 2221621 cgattacatc atagccctgt tcttttaaca gcagggccgc cacagatgag tctactccgc 2221681 cggacatgcc gacgacgact cttgtatcct ccggccgttt ttccatttca ttcactccaa 2221741 ttactacgcc gccttattat gtcagccgtt tgacaacgtc ggccacatgt ttggcagcag 2221801 ttttcacttg ctcagccgta ttgccgaggc cgaagctgat tcgaatagag gacgtcagcc 2221861 ggtcactctc ttcgccgaac atagcagtca gaacatgtga cggcaggact gaaccggccg 2221921 tgcacgctga accgctggag acagcgacac cagccatatc aagattaacc agcagcgctt 2221981 ccactgacac accggggaaa taaagattca gaacatgcgg cagactatgc tctttgtccc 2222041 cgttgacctc gaatgccaca cctgcatctc taagcgtgtc ggcaaagatt gctttaaacg 2222101 attgatactt ctcgtttttt tcgtcacgtt cttcacttga cagcttgatc gcttctttca 2222161 gcccgacaat gcctggaaca ttttccgttc cggcacggcg ttttctttct tgctctcctc 2222221 cgaataaaag gggtgaaagc ttcacatctt tactagcata taaaaagcct gtcccttttg 2222281 gcccgttgag cttgtgcccg gaaacagaca gaaggtcaat atggctgttt ttcacatcaa 2222341 ttggcagcaa cccgaatgcc tgaacagcat cggtatgaaa ataagctttg tgttccttta 2222401 acagctcacc gatttcttcg atcggctgca ctgttccgac ttcattattt ccatacatca 2222461 ctgtcacaag gattgtatca tcacgcagtg cttctttcac ctgttttgca ctgactcttc 2222521 cattttggtc aacgtccaga tacgttatgt caaatccgtc tccctcaagt ttttcacatg 2222581 tgtgaagcac ggcgtgatgc tcaatttttg ttgtgatgat atgtctgcca agatcttttc 2222641 ttgcaagtgc ggttcccatg atcgccaagt tatcagcttc cgttcccccg cttgtaaaaa 2222701 tgatctcctg ctctgccgct ccgatttctg ctgcgatctg cgctcttgct tcatccaccc 2222761 attttcgaga ttctctgcca aatgaatgaa tactggaggg attaccgaaa ctgccggaga 2222821 agtgcggtat catttgttcc agcacgcgct catccatcgg agacgttgcg gcatgatcta 2222881 aataaatccg ttccattatg tttacacctc tgatctaaat atagaacata taagcttctt 2222941 gctctccgtc tgtatagctg gcaagatcct ctaatgttgt actgtctaaa acctctttta 2223001 cagcatcccg gatgcgaatc cagagctcac gcttggcagg ctcctcatct tccagcactt 2223061 caacagggct gatcggcccc tcaagcacac ggataatatc tcccgcagta atggcatccg 2223121 gctcactgcc taatacatat ccgccatatg cgcctctgat gcttttcact aaaccggcat 2223181 ttctgagcgg cgataccagc tgctccaaat aatgctcgga caaattattc gtctgtgcga 2223241 tgctttttaa tgaagtcggg ccttcaccgt gcttttttgc aagctcgatc ataatggtga 2223301 gcccgtatct tcccttagtt gatattttca acatgaacac ctctgttatt tcatgatttt 2223361 ccacatttat aatggtaatt tctatatgtt tcgtccgttt attatcttat agaccaactg 2223421 ttattataac ataccttcag cgaattttca ttgaggcaga aggaaagggg cctttaccct 2223481 tttctaatgt acggttttcc gttaccctgt aattaagtaa ggagagatga tagatgaagc 2223541 cattggcata tcggatgcgt ccgacaaaaa tagaggatat tatcggccag cagcatctgg 2223601 tggctgaaga taaaattatt ggcagaatgg tccaggcaaa acatttgtca tccatgattt 2223661 tgtacgggcc gcccggaatt ggaaaaacat caatcgcaac agcaatcgcc ggttcaacaa 2223721 gtattgcttt tcgaaagctg aatgctgtca ttaacaataa aaaagatatg gaaatcgtag 2223781 ctcaggaagc caagatgtcc ggccaagtga ttttgattct ggatgaagtc cacaggctgg 2223841 ataaaggaaa acaggatttt ctattaccct atttagaaaa cggaatgatc attttgatcg 2223901 gagcaacgac ggctaacccg tatcatgcca ttaatccggc gatcagaagc cggacccaga 2223961 tttttgagct tgaaccgtta acacctgaac tgattaaaca ggcactggaa cgtgcgctcc 2224021 atgatgagca tcggggcctt ggcacctatt ctgtatccat tgatgatcag gcgatggagc 2224081 attttgccca cggatgcgga ggagatgtcc gctccgcttt aaatgcgctt gagcttgccg 2224141 tgttgtcaac gaaggagtca gcagacggtg aaattcacat tacattagaa accgcggaag 2224201 aatgcttgca gaaaaaaagc ttttctcacg ataaagatgg tgacgcgcat tatgatgtac 2224261 tgtccgcttt tcaaaaatca atccgcggct ctgatgccaa cgctgctctt cactatttgg 2224321 ctagattaat tgaagccggt gatctggaga gcatcgcaag acgattgctt gttatcgcct 2224381 atgaggatat cggtttagca agcccgcaag ccggccctag agtgctgaac gctattcaga 2224441 ccgctgagcg agtcgggttt cctgaagcgc gaatcccgct ggccaacgca gttattgagc 2224501 tttgcctctc accgaaatca aactctgcca ttctggcaat cgatgaggcc ctggcagata 2224561 tcagagccgg aaaaattggg gatgtcccga agcatttaaa agacgcgcat tataaaggag 2224621 ctcaggaatt aggaagagga atcgactata aatacccgca caattacgac aacggttggg 2224681 tcgaacaaca atacctccct gatcctctga aaaataagca atactataag ccgaaacaga 2224741 ctggaaagtt cgaatctgcc ttaaagcagg tgtacgataa attaatgaaa agaaaataaa 2224801 acaaaaaaac agccttgatc atcaaggctg tttttatgca ttatttatcc ttcacacgtt 2224861 tgatttcaat gtctttcaaa agatccatga caacatgtcc gcccataatc aaacctgcaa 2224921 ctgacggcac aaaagcatta gaggaaggcg gcatttttgc tttacgtatt ttcgcttcgt 2224981 cattccccac ttcttttctg acatcttccc gaataacaat cgggctttca tcagagaaaa 2225041 tcacttgaac gccttttttg ataccctcct tgcgtaattt cgtacgaacg accttcgcaa 2225101 ttggatcagt gtgcgttttt gagatatcag cgatttggaa gcgtgtcgga tccgttttat 2225161 ttgcagcacc catgctggag atgagcggaa tatcccgttt tagacattct ttcattaaat 2225221 gaattttata acaaatggtg tctgacgcat caatgacata gtcaagacca tagtcaaaaa 2225281 actgctcata cgtttcctcc gtatagaaca tttttaacgc gatcacttca cactccgggt 2225341 taatgtctgc gatccgcgcc ttcattaaat caactttcgg ctgtccgaca gttgaaagca 2225401 gcgcgtgaag ctgacgattt acatttgtaa tgtcgacatc atctttgtcg acaagcagaa 2225461 tgcggccgac gcctgaccgc gcgagagctt ccgccgcgaa cgacccgact cccccgactc 2225521 caagcacagc aactgtgctg tttttcagcg tttcaaggcc ttcttttccg atagctaatt 2225581 cattgcgtga aaactggtgt aacaagaacc tcactccaca ttcgtattct ggtttcatct 2225641 ataaaatggc tgatccatga gcagccgttt tttctgcgca caaaaaataa agtcccaata 2225701 gtgccgttgc agctttcctt tgttttgaac ccgctctcag caggtgggtg ccctctttta 2225761 aatcttgtaa gtcctcttta ccgaatgaaa agaggcatgt acgccattta aaaatgcggg 2225821 ctcccaaatc aaaaaaatgt tcggtcaaaa ctaggtgtac aactaacaca tcaggacttt 2225881 atttaacttg tcaaaatcat atcacagacg attttgattt tcaagaatcg aactgcaaat 2225941 tcagttctta acttttttct tgatagaaag atgaagctcg tcaagctggg cgtcgcttac 2226001 ttcgcctggc gcttctgtca tcaggcagct tgcacttgcc gttttcggga atgcaatcgt 2226061 atctctcagg ttcgtacgtc cagcgagaag cataacgaga cggtctaagc cgagtgcgat 2226121 tccgccgtgc ggaggagcgc cgtattcaaa tgcttccagc aggaatccga actgttcagc 2226181 cgcttcttct ggtgagaagc cgagaagcgc aaacattttt tcctgaatat ccttttcgaa 2226241 aatacggatt gaaccgccgc caagctcata gccgtttaag acgaggtcat aagcttgcgc 2226301 tttcatgtct tcaggcgctg tttcaatcag ctcaaggtct tctcggacag gcattgtgaa 2226361 cggatggtgc gctgcgtaaa aacggccttc ttccggatca tgctctaata gcggccagtc 2226421 gatgacccat aagaaattga acaatttttc gtcaatcagt ccgcgttctt tcccaagctt 2226481 taagcgcagg gcgccgagtg atgcggccac aacttcgaat tgatccgctc cgaacagcag 2226541 caaatcacct tcagcagcat caagtgcttc aatcagctta gactgctttt cttcatcaaa 2226601 gaatttagcg atcgggcctt tcactccgtc tgcctcaacc ttcacccagg caagcccttt 2226661 tgccccgtag tttgcagcaa aagcgccaag agcgtcgatg tcttttctgg agtaatcgcc 2226721 ggcaccgcct tttacattga tggctttgac cacgccgccg tttgctacag ctgatgagaa 2226781 cactttaaat tccgtatcct ttacaatgtc agacacatcc gtcaaaagca tgtcaaaacg 2226841 cgtatccggt ttatcagacc cgtacttgtt cattgcttcg tcatacgtca ttcgaggaag 2226901 aggaagctga agttcctcac cttttgtttc acgcataacc tttgccatca tctcctcagc 2226961 caatgacata atgtcttcct ggctcataaa ggacatttca atatcaattt gcgtaaactc 2227021 aggctgacgg tccgcacgca agtcttcatc gcggaaacag cgggcaattt gataatatcg 2227081 ttcaatgcct gataccatca gaagctgttt aaatagctgc ggagactgcg gcagcgcgta 2227141 gaactcacct tcgtgcacac ggctcggcac caagtagtca cgtgcgcctt caggcgtgct 2227201 tcctgttaaa atcggcgttt caatatcaag aaacccattt tcatctaaaa agctgcgaac 2227261 agctttcgtc acgttatggc gcagctgcat cgtctggaac atagccggtc tgcgcaaatc 2227321 taagtaacgg tgttttaaac gaacgtcctc tgacacttct tcagcttgat cagaaatcgc 2227381 aaatggaggt gtctttgcag catttaatac gttcactcca tcagcatgta tttcgatcgc 2227441 gcctgttttc aaattcggat taactgttcc ctcttcacgc gccaccactt ttccttgaat 2227501 atcaagcacg tattcatttc tgatgccttc cgcaatagca agcgcttctt ttgacacatc 2227561 agggttaaaa acgacttgaa caatgcccgt acggtcacgc aagtcaataa aaatcaatcc 2227621 gccgaggtct cgtctttttt ggacccagcc tttcagcgtt acagattcgc caattgcttt 2227681 ttcagttata tcaccgcaat aatatgttct tccaaacaat gcgtttcact ccttatccct 2227741 tttggtttgc cttcatcaca tgtataaatt catcaagtgc cacttcaatc tgttcgcccg 2227801 tctgtgcatc ctttacattg attttgtttt gggcaagctc atcttcaccc aaaatcgcaa 2227861 taaatctggc ctttaagcga tcagctgttt taaactggcc tttcattttc ttattttcat 2227921 aatcgatttc actggaaatg cctgcttctc tcagtttgta caccaatgaa acagaataat 2227981 cctttgcttt ttcgccgagt gtgacgatat agcagtcgat tcccttatca acaggcagct 2228041 ctcttttttc agcatcaatt gcggcaagca agcgttcgat gctcatcgca aatccgatgc 2228101 ccggtgcttc aggtccgccg atctgttcga caagcccgtc gtagcgtccg ccgccggcaa 2228161 gtgtcgtaat cgcgccaaag ccctccgcat tgctcataat ttcaaatgcg gtgtggttgt 2228221 aataatccag ccctctcaca aggttcggat cgatttcata cgaaatgcca agatcattta 2228281 agtattgttt cactttttca aaataagcgg ctgattcttc atttaaatat gtcaaaatcg 2228341 aaggtgccga tttcatcagc tcatgatcac ggtctttttt gcagtccaaa attctaagcg 2228401 ggttcgtgtg cagccgggac tggcagtctg aacaaaattc ttcgatgcga ggctcgaagt 2228461 gtttcacgag cgcttctctg tagcttttgc ggctatcttg atcgccgaga ctgtttatga 2228521 caagcttaac gttttctaaa cctgcttttt cataaatact catcgcaagc gccattactt 2228581 cagcgtcgat tgcagggtct ttcgaaccaa tcgcttcaat tccaaactga taaaactggc 2228641 ggtaacggcc cgtctgagga cgttcataac ggaacatcgg cccgacataa taaagctttg 2228701 tcggctgtac aggatttgcg aacagcttgt tttcattaaa agcgcgaacc gcagcagctg 2228761 ttccctccgg acgaagcgtc aggcttctgc ctttgcggtc ctcgaaggta tacatttctt 2228821 tttgtacgat atccgttgat tctccgacgc ctctggcaaa cagttctgta tgctcaaaaa 2228881 tcggtgtgcg gatttcttta tattgataag tgcggcaagt gtctctcata atttgttcaa 2228941 caaactgcca gcgatctgat tctccaggca gaatatcctg tgttcctctc ggaatgttat 2229001 atcccatagg tagacctcct tatgtattcc ttataaaata tccaatgatc gttaatgatg 2229061 aaaatgaaaa aaactcccgc ccctactata catgatagta gggacgagag ttatacccgt 2229121 ggtgccaccc tagttggaat acgttcatat tcccgctcga tcctttaacg caggttcacg 2229181 ttcactgcct aatggcgtta ttcacgcgtt cagcaggaaa cctccggagt gttgtttcga 2229241 gaaagacgca atgggatccg ctttcagcct ggggcgggtt cctctctaat catgcaatct 2229301 gacctactct tctccattat tggttcaaat ctttcatcat ttgctatgta ctcaatttct 2229361 attataataa tgggattggg gttctctgtc aagctttatt ccggttgttt ttcctcagcg 2229421 ctgcttcttt ggacataaga ccaaattcag atgctgtttc cgtaagataa ccagtcgtat 2229481 cgggatctgc gtgatcgctg taatgcagat tcgcttcacc gtcgtgaaat gcacgtccca 2229541 tttttggatg atatttcatg atttgcacac ctttttgatt gtatttacgc ttagtataaa 2229601 caaatcattt tatttttatt taaaaatcag aaaggacttt acgatattaa acaagaatgc 2229661 ttttttaatg atcatcagaa aggaggacac aatgaacaag aaatactttg tccttattgt 2229721 atgtattatt ttcacctcag cgctattccc gaccttttca tccgttacag ctgctcaagg 2229781 agaagcggtc atcgcaacag atgaaatgaa cgtcagaagc ggcccagggc ttagctacgg 2229841 cattacagcg gaagtaaaaa agggagaacg ctatccaatt ttaaaggaag atggagactg 2229901 ggtgcagata cagcttggtt ctggagaaaa gggctgggta gtctcctggc ttattacaaa 2229961 ggaagaccag gccagcacaa gctcctcagg aagcagtgac actgtgacat caacagaccc 2230021 cgatctgcgg atgagaagcg gcccgggcac ttcctacgaa gtcatcggca aattcccgca 2230081 aggcagccaa gcatctgtca ttgataaaga ttcgggctgg atcaagatat cctatcacag 2230141 tgccaccgga tgggtatcat ctgaatatgt cacatcagga ggcagcagtt cagcgtctga 2230201 tgagagtgac caaaccgagg attccggtgc gtcaacgacg ggcacagtcg gtgtttcttc 2230261 gctaaatgta agagcctccg cctcacatga cgcggcaatt ataacaaaac ttgatcgcgg 2230321 aacgaaactg acggttctca acgagaaaaa tggctgggct cacattgagg tgaacgggct 2230381 aaaaggctgg gttgcaagcc attacctttt gactagttct gttccagctg atgattcagc 2230441 aaatgccggc agttcatcct ccgctaaaaa agcctatatc atgtacggag gaacgaatct 2230501 aagaagtgat gcgtcaacat cagcttcgat cgttgagcgc gctgccaaag gagattcata 2230561 caccattacc ggttcaaagg gaagctggta tgaaataaag cttgataacg ggcagactgc 2230621 ttatgtagcc aattgggtgg tccaaacgtc taaaagcgca gaagaagcag gtgaaccgcc 2230681 agtctctgat tccccgtctg gaaacggctc tctaaacaat aaaacgatta ttgttgaccc 2230741 gggacatgga ggaaaagaca gcggaacgat cgggtattcg gggaaattcg agaaaaacct 2230801 gacgatcaaa acggcaaaac tgctcgccag caaacttaga tcggctggag cggatgtata 2230861 tgtgacacgc caggatgata cctttgtcag cctgcagtca cgggtctcta cctctcacta 2230921 ccgtaacgct gacgccttta tcagcattca ttatgacagc tatgcggata cctctacaag 2230981 aggcagtaca gcatattact acagtcctgc caaagatcag gaactcgcat cagatgtcca 2231041 ctcagaagtg gtgaagcgtt cttccattcc agaccgcggc gtattattcg gagattatta 2231101 tgtgctccgg gaaaacagac agcccgctat gctgtacgag ctgggatatg taagccatcc 2231161 gcaggaagaa gccattgtac atagcaattc ataccaagaa aaagtaacag atgggatcga 2231221 aagcggatta gagaaatact tccaataaaa aaagctgcct tttggcagct ttttttattt 2231281 tgaatccata atgagcgtga ccggtccgga gtttgtaagc tgaacatcca tcattgctcc 2231341 aaacgttccg gtctccactt tgattccttt ttcacgaagc aggtcattcc atttttcata 2231401 aagacctaaa gctttatcag gtttggccgc gttcatgtag ttcggccggc gccctttttt 2231461 cgtatctcca taaagcgtaa actgtgagac ggataaaatc tctcctccta tatctacaag 2231521 agacagattc attttccctt cactgtcatc gaaaatacgg agattgacaa ctttatcggc 2231581 taaataagct gcatcatctt ctgtatcatc gtgagtgatg ccgaccagca ccataaggcc 2231641 ttgtccaatt tggccgacga cctcttcgtc cactgtaacg cttgcttctg ttactcgctg 2231701 aacaactaat ctcttttcta acccctttag ttcatgacgc ggcgcacaga atagatatct 2231761 ctaatctgtt taatacgctc gacgacttta tgcaagtgat tgatattctg gataaaaatc 2231821 gccatatgga tggttgccac tttattgcga tccgatttgc cagagacaga tgaaatattg 2231881 gttttcgttt cattcactgc ctggagtacc tcgttcagca atccgcggcg gtcataccca 2231941 agaatctcta tctcaacatt gtattccttg cgcttttgaa cttgtgactc atgttcccac 2232001 tctaccggga tcagccgctc ttgggcttca ttcgttttga cattcggaca gtcttcgcga 2232061 tggaccgaaa cccctctgcc ttttgtgata aagccgacaa tatcatcacc tggcacagga 2232121 ttgcagcatt ttgataaacg gacaaggagg ttgtcaatgc ccttgacacg aacgccagct 2232181 tcccgttttc ttccttgcgg gtatggctta ggttccccag tgacttcctg aacgatcttt 2232241 tcctgttctt cctggtcgcg ctgctttctc tctttttctg ttaggcggtt cgccacctgc 2232301 agagctgtga tgccgttgta accgaccgcc gcgtacatat cctcttcatt tgagaaatta 2232361 aatttgtcag caaccttttg aatattctcc ggcgttaaaa catccttcaa ttcaaaatcc 2232421 aagtttttaa tttctttttc gaccagctca cggccttttt cgacattttc ttcacgccgc 2232481 tgtttcttaa agaattgacg gattttatgc ttcgcttggg atgtttgggc aagcttcacc 2232541 caatcctggc tcggaccgta ggaatgctta gaggtgagaa tttcaacgat atcacctgtc 2232601 cgaagcttat ggtcaagcgt aaccattttt ccgtttactt tggcaccgat tgttttattg 2232661 ccgatttcag agtgaatccg gtaagaaaag tcaatcggaa cagaaccgga cggaagctcg 2232721 attacatctc cttttggcgt aaagacatac accatgtcag agaacaaatc aattttgagc 2232781 gattccataa attcttctgc atctgtcgat tcattttgaa attctaaaat ttcacggaac 2232841 caagaaagct ttttctcaaa ggttgcacct tcattggctg ctttcccttc tttataagcc 2232901 cagtgagccg caaccccgta ttccgctatt tcatgcattt caaaggtgcg gatctgcact 2232961 tcaagcggat cgcctttagg cccaataacc gttgtatgaa gcgattgata catattcggc 2233021 ttcggcattg cgatataatc tttgaatctg cctggcatcg gtttccagca tgtgtgaatg 2233081 atgccaagca ccgcgtagca gtcctttatg ctattcacaa gaatacggac agccaacaaa 2233141 tcgtaaattt cattgaattg cttattttgc agcaccattt ttcgataaat gctgtaaata 2233201 tgtttcgggc gtcccgagaa gtcagccttg atatttactt cttcgacacg tttcttcact 2233261 tcattgacaa cctcatcgac ataaagctct cgttctgcac gtttcttctt catgaggttg 2233321 acaattctgt aatattgctg agggttcaaa taacggagcg ccgtatcttc caattcccac 2233381 ttaatttttg aaatcccgag acgatgcgcc aaaggagcaa aaatttccag cgtttcattg 2233441 gagattctcc gctgtttttc ctgaggcaga tgtttcagtg tccgcatatt gtgaagacga 2233501 tccgccagct tgatcaatat gaccctgata tcttgagcca tagcgacaaa cattttgcga 2233561 tgattttccg cctgctgttc ctcttgagat ttatatttaa ttttgccgag tttcgttacg 2233621 ccgtctacaa gcattgccac ttcttcggaa aatgcttctt tcaggtcatc gagcgtcaca 2233681 tctgtatctt ccacgacatc gtgcaaaaat ccgcccgcga ttgtggaagg gtccatttca 2233741 agatcaacga gtatccccgc aacctgaatc ggatgaataa tatatggctc gcccgatttg 2233801 cggtattgct cgcgatgagc atcttcagcg tacagatatg ctttttcgac aaatgcgata 2233861 tgctcatcag atagatagct gcgtgcttta tctataactt gctcggcagt caatacttgt 2233921 tcgttcgcca tggaatcacc ttttttaaaa tgtaaactgt attgtagttt attatcaaga 2233981 aaaaaacgaa agatgtaaag agcagaagtt caaatagcca aatattatat aaaataaatg 2234041 caaaacaata ggaaaaaagc accctgacat ggagtgcttt ttcgttatgc ggttatcctt 2234101 agtatttcat caatgttaag atgtcgtaat cttcgagctt atttctgccg tcaaggtaag 2234161 aaagctcgat taagaaagcg ataccagcaa caacgccgcc aagttcttca acaagtttga 2234221 ttgtcgcttc aattgtgccg cctgtcgcaa gcaggtcatc tgtaataagc acacgctgac 2234281 caggcttaat cgcatctttg tggatcgtta atacgtcttt tccgtattcc aagccataat 2234341 ccactttgat tacttcacga ggcaacttgc cttctttgcg gaccggcgca aaacctacgc 2234401 caagcgcgta agcaacggga cagccgataa taaagccgcg cgcttcaggg ccaacgacca 2234461 aatcaatttg cttttctttc gcatattcaa caatttgatc tgtggcatag cggtatacat 2234521 cgcctttatc catcagtgtc gtaatatctt taaattgcac gccctctttc gggtaatccg 2234581 gtacaattgt tacgtattgt tttaaatcca tctgttttat gtcctcctcg tactttcata 2234641 agcctctgaa tcttgtttca tcagcttatt cagccattcc ttcagctctt cagcagaaga 2234701 ataattcagc ttttgatcca gttccatcag ctgctgtttc gcctgatatg tttgtgagtc 2234761 tgttaagtcg cgtttctttg ctccgctcac aacagacagc acaccattct ctattttaac 2234821 aaaaccgaga tcaaaaaaca cctttgtcat gaaattgatt gtttcaacgg accagccttt 2234881 atgttttgca agctctgaac cgtgtttttt cacgtcaaaa gcgcctcttt tcagcaagaa 2234941 cgcataatac catttaaagt ggtctcttgc gggaaaagtt gataaaaagt ggtcctcatg 2235001 attgagaaaa ataaaatata tccgctcggg cgcctttcct tccagcaaac gtgcgagcat 2235061 gtccagcgaa ggcggcggat ccagtaatac aatatatgca ccatcgaggt caaacgcctt 2235121 tgcttgatct ttagaactga tgacgtgcac ttctcggcga aggtcttcag tttgaagtaa 2235181 tgttgttgag tcttctttga aagagacaat ggcccgttta gcagatggaa gggcggaaac 2235241 tgtgtcttcc cacgtccgtt ttccccttaa atcaaacagc tgccattcag aaacagcggc 2235301 atcctttatc ataagctgcg gcttttttcg attgttccat tcgttgattg acatctcacc 2235361 gacaatggaa attcttgaac ccggtacgat gccttcttga agctcgcctt tattaaaacc 2235421 gacgcaatca agctgggacg actcgtttct gatcgtcatt ttgacatgag ttttatttgc 2235481 ccctatcttg cggacatctt ccagtactgc attttctacg agaacgtgcg gtttcgggtt 2235541 cagcatgcca aaaggagaca gcatgttcat ttctgcgatg ctttcaactg taatgtcttc 2235601 gacgccgcag acaaggtcga cttcctgtac gggaataaaa tcctcttccg taagcgtatt 2235661 gtccgctatt tcattcagcc tgcttcgcaa atccggcaca tcttcggctt tcagcgtcat 2235721 ccccgcagcc attggatggc cgccgaaatg aggaagaata tctctgcatt cagaaaggct 2235781 ctcaaataaa ttaaatcctc tgatgcttcg ggccgaacct ttagcgattc ccttttcttc 2235841 atcaatacca agaacaatgg ccggtcggta gaaacggtcc acaagctttg aagccacaat 2235901 cccgacgact cccgggttcc atccggcttt ggccacgaca attgcagttt gatcgagccc 2235961 ttgctgttca accatttcaa tcgcttcatc cgtcattttg ctgaccattt tttggcgctc 2236021 tttgttcagc tggtcaattt ctgcggcaag ctcttccgct tcaaacgaat cctctgacat 2236081 aagcaaatga acagcgggat ccgcctgttc gattcttccg acggcattca gccttggtgc 2236141 gagctgaaat ccgactgttt cttcgttcgc ttctccgatg tctccgcctg acagcttaat 2236201 cagctctttt aagccgagcc gatttgtccg tcgaagcctt tcaagtccta gtgttgctat 2236261 taatctgttt tcgtcatgca gcgggactag atcggcaatg gtgccgatag ccgccaggtc 2236321 aagcagttca tcaggaagtt cacccaataa agcgtgggca agcttaaacg cgactccaac 2236381 cccggcaagc tctttaaacg ggtaagtgca gccaggctgc ttcgggtgga cgatcgcacg 2236441 gacatccgga agctccggtc ccggttcatg atgatcggta atgatgacat ccagtccgag 2236501 ttcctttgcc accttcgctt catgcacagc ggcaattcct gtatcaaccg taatgatcaa 2236561 agagaagccc cgttctttaa tcgaacgaaa cgcctgttca ttaggtccat atccttcttt 2236621 aaaacggtca ggtatataaa aatcaacttg agccgacagt ttttgcagcg tgtgaagcat 2236681 cactgacgta cttgtaaccc catcggcgtc ataatcgcca tatatcataa tcttttcttg 2236741 ttgtgaaatc gcctgtttta ttcgatctgc cgcttctttc atgcctttca tttcaaaagg 2236801 atcataaaaa tcggcatcct ttgtatgtaa aaacagccta gcgctttctg ccgtatcaaa 2236861 gcctcttttt acaagcaggg acgcaacaag aggtgttata tgcaattgtt ctgtgagtga 2236921 tttgacctta tcctgatctg gtcgctggat ttcccatcgc atttttgacg ctaacataaa 2236981 ttcacccctc aaccacccta ttatactaga gcaggctgag gggtttcaaa taatattcga 2237041 aaactagtct tttttctcaa tcatggctga tgcatcctgt gtgtcagtct gatcagcaag 2237101 atgagtatcc tcttgtttat gtattgctgt tctattttct ttccgcaagg tttttatttc 2237161 ccgcttcaat ttcattacct gaaaaatgcc gacagaaaat acgatcagtg ctcccattaa 2237221 aactgagccc aaaataacaa gaatgagcgg ccattctgat cttccaaaca ggtaatcaac 2237281 ttctacggat cgaacattaa tgactgcgaa aatagcgaca attaaggtga aaataagtgc 2237341 gaaaataatg gtccattgtt tattcattct cttttccccc aaacttctta ttgaggtaac 2237401 tttcccaatc aagactggtt ttaaacatgg cttaacacta ggttaagctc cctttgctgt 2237461 taatttttcc cggatcagcc tcttcagtcc ggttccctca ccggaaatca caagtgtatc 2237521 gccttcgtca atgactgttt cagagctcgg attcagttgt ttatcctgat tctttttaac 2237581 aattgcaatg accgtcacat gatattcctg acccacattc aaatcaccaa tcgtctgatg 2237641 aatggcaggc gctcccgcct ctgctttaca ccactctata atcaaatcat caagggctga 2237701 ctcgacctgt tctaatgctt tcggtttata tgccattccg ccaagaattg cagacatttg 2237761 ccttgcttca gcgtcatcaa actgcacgga ggcaacacat tcctcatggt cgttttcgtc 2237821 aaaatagtaa agctctctcc gtccgtcatg atgaatgata attgaaattt tatcacggtt 2237881 tctagtaatc atttcaactt tttgtcctat gcccggcagc tctgattcgc gaaccctcat 2237941 atataaaccc tcctacatat ctgaaaacca gccataaaca cttttaacac catatatatg 2238001 tttaaatgta agcgtatgtc attatagcaa atgtctattt taagttcaat gaaacttcaa 2238061 aaaacaggct gccctgcaga ggacagcctg atatttttta ttgcgccgaa tcttttttca 2238121 gttctcttcc tttccatgca agccaaattt gtgcggcaat gtatagagaa gaataaacgc 2238181 ctgttaacag cccgaccaat aaagcaattg agaagttagt aatagaagat gctccaaaga 2238241 tcagcaatgt cacaacaaca atcacaacgg ttaatacagt gttaattgaa cgtgtaaagg 2238301 tttgctgcag gctcaggttt acaatatggt tcagatcggc aaaggttttc ggcttacgct 2238361 ttttcatatg ctcgcggacc ctgtcaaatg taacgattgt atcgttaatg gaatacccga 2238421 ttatcgtcaa gatggccgcg atgaatgtaa catctacctc aagccttgta atactgaaga 2238481 acgtgacgat aaagaatgcg tcatatagca atgaggcgat ggcagcaatc gccattttgt 2238541 attcgaatcg gattgaaacg taaataatga tgccaataga agctatagca actgcgtaca 2238601 gcgcatttct cgccagctcc ttaccgactg tcggtgaaac tgtgctgaca tttggatcag 2238661 atccgtattt gtctttaaaa tacgttttta cttttgcaat ggtttcttta tctggcaccc 2238721 cgacaaaacg ggcaacaccg atattgctct tttcgcctga cagaactaca gtatcagggt 2238781 ccatacccag agattcaaaa tccttctcaa cttgctctgt cgtcagctta tggtcgcttt 2238841 gcacttcaat ccgtgcaccg cttgcaaagt caatgccaag attcagcctg aacacaagca 2238901 ggataataat cccggcaacc gtgaccgcac tggagaaaat aaagaagtat ttgcgtttgc 2238961 tcgtgaaatc ccatttttgg aatggcgtat gcggctctgt attttcatcc gtatcctgaa 2239021 tatccatgat atgtttctta ttgacaccaa accagccttt tttccgatca agccatctgc 2239081 tttccacaag gagagcgagg agaaatctcg ataagaaaac ggcagtgata aagcttgtca 2239141 aaatcgatag gatcagcatt gtcgcaaacc ctttaacaga gcttgtccca aagataaaga 2239201 gcacaaccgc tgcaataatg gttgtaatat tcgcgtcaaa aatcgtcgca aatgaccgtc 2239261 tgtttcctga acggaaggca gagcggactg actttcctag cttgagctct tctttaatcc 2239321 gctcataggt aataatgttg gcgtcaacag ccatcccgac acctaaaatg agagcggcaa 2239381 ttcccggaag cgtgagtacg gcattcatcc agtcaaagat ctggagtgta atgtagatat 2239441 aaacagacag cgtaatcacc gcgattaatc ccggcagacg gtaatagaaa agcataaata 2239501 agaaaataat tgcgataccg acaataccgg caaacaccgt atcatggaga gcctgctggc 2239561 cgaattgcgc gcctactgat gtcgaatact tttcagtcag tttcacagga agtgcgcctg 2239621 cgtttaaaat gctggctaaa tctttcgctt cttgagctgt gaaatgacct tcaattttta 2239681 catcagttgt atttagttcc tgacttacat ttggagcgga tacaaattta ggatgctctt 2239741 tttgaacttc tttcttaaag gaatcacctt tatcataatc caaccaaatg acaagctggt 2239801 tgtttggcgc cattttcatg accttcttgg tcacttcacc aaatttatca gcgtctttca 2239861 gcttaatcgt gacaattggc tcatttgttg tgctatcata agtttgttta gcgccgtttt 2239921 cgactagatc agcaccgttt aacagttcct tatcatttgc atctctgaaa gaaagctgcg 2239981 cttcagtcgc caaaatttca cgcgctctgt tttggtttgt cacgccagcg agctgaacgc 2240041 gaatccggtt attcccttca atttggatgt tcggttcgct gacaccgaga acattggccc 2240101 ggcggttcag tgcctctact gtgctgacca gaacgtcttt tgtgattttg tcaccttttt 2240161 ttacaggctg tacatcatac agcacctcaa atccgccttg caaatccaat cctaacgtaa 2240221 tattgttagc ggcaggcttc gtaaagtagc ccaagcccgt gccgatcaat agaacgaaaa 2240281 ggaaaaacgc aatcaagcgt ccttttttca ttatgtatat cctcccttaa acctgtgcga 2240341 atcaacctgc tatctcagca gttcttccaa tgcttcctgg ccctcttcac tgcccagcca 2240401 attagacgtt ttaaatgact caacggttgc atagttcata aattcgccaa ttttcactga 2240461 taaaatatca ctcgccagtt cataaatgct cagttccgtt ttctttttcc acttcttatc 2240521 tgttaagtat gaccacaaac tttcgagttc aacatcatca tacccgagaa tcttaaactc 2240581 ttccagtttg ctgtaaagaa acggcctgac gtggtcttta tatagatcgg ctggatgctt 2240641 ctccacgaat tccacgctcc ttttttattg tttttcaaga agacttgtca tgcttggacg 2240701 acatatacgc atatctttat tgtatatgat tccaggtagt ttgagaaggc agggggtaaa 2240761 aatggcgaaa cagacgtttt taaagggcac tcttatcctt atcgcagcag gaatggttac 2240821 aagaatgctc gggtttgtca accgggtggt tatcgcccgt tttatcggtg aagaaggagt 2240881 cgggctttac atgatggcag cgcctacttt cttcttggcc actacattaa ctcaattcgg 2240941 tctgccggtc gcgatcagca agctagtcgc tgaagccagt gcgcgcggag atcatcaaaa 2241001 aacgaaaaat attttagtca tgtctctgac cattacggga gtgctcagcc tcatctttac 2241061 accgctgttt ctgtttttcg cccctgttat ggctgaaacg atgctgacag ataagcgaac 2241121 actgtatccg ctcttggcca ttacgcctgt tgtgccgatt attgctatat cgagtgtgct 2241181 gaggggatac tttcaaggaa aacagaatat gaacccgctt gctatgtcac aagtccttga 2241241 acaggttgtc cgcatttcac tcgtggctgt ctgcacaacg atttttctcc cttacggaat 2241301 tgaatatgct gcagcggggg caatgctatc ctcagtggca ggggagctgg catcacttct 2241361 ttatttattc gtttgcttta agtataaaaa gacaattaaa atcagaaagc attttttaca 2241421 gtcaattaaa aacggaaaac aaacctttac ccaattaatg agcgtgtccc ttccaacaac 2241481 cgggagccgc tttatcggaa acctctcttg gtttttcgag ccaatcgtcg tcgctcaaag 2241541 ccttgccatc gccggtgtgg caacagttgc cgcaacaaag caatacgggg aactaaccgg 2241601 ctttgccatg acgctgctga ctctgcccag ctttattaca tattctttgt cgaccgcgct 2241661 tgttcctgcg atcagtgaag gaatggagca gaaaaaattg caggtggtgg aataccgctt 2241721 agaacaggcg atgcgtctct gtctgctcag cggaggcatt tcagttgtta ttttatttgt 2241781 atttgcggat gagctgatga gagtgatgta cggttcctca ggcgcagctg tatttataaa 2241841 agtgatggcc ccgttttttc tgctttatta tttccaaggc ccgcttcaag ctgtgctgca 2241901 ggcgcttaat ttggcaggag ctgcgatgat gaacagctta atcggagcgc ttgtcaaaac 2241961 aggccttatt tttgtccttg ccacaaggcc ttctcttggc attatgggcg cggcattagc 2242021 cattgtgaca ggcatggtgc tcgtcacgct attgcacgca gcaaccgtaa gcaaagtgct 2242081 gccgatcagc atcaaaatca aggagtacgc gctcagcttc gctgttattg taatttgcgg 2242141 attcatcagc tccgccatca aacaatatat aagctttgga gcatctgagg ctgtcaatct 2242201 agccggatgg attgcggcga gcgccgccat ttatatgatc ctcctgctcg ttttccgttt 2242261 aattaaaaaa gatgagcttc gccgcattcc cattatcgga cggttgatca tccgataatg 2242321 gtcacgtgcg gtgcccatct ttttcatcaa tatatatttc tccgtctgta aacgagcaaa 2242381 atgaaatatc tgaagggttt gtgtatccgt gtttttgcaa actttcaagc agccattttc 2242441 tatctttact gattctggac aggttttctg tttgaatgaa gccgtctata atgagcggca 2242501 tttcgagctg ccgatgctct ccgctgtttt ctttcttaac aatagtcagt ttgcccgacg 2242561 gctctaaaat agcaaatgat acgtcagcta ctctgtcgat gctattttct ctgagctgaa 2242621 ccattaaatc atcaaaatta taacgctgtg atttcatggc ttcttcgtca atttttccat 2242681 atttgataat tatggtcggc ttaccgtcaa gaagctggcg gacttttcgg ttttttaaag 2242741 aaaagtatgc caaagtcact tgaatgatca ttaatacaag cattggcaaa atggtatgaa 2242801 atagatgatc gtctacgttt tctatggcta aaacggcaat ttcagccatc atgataaaga 2242861 caacgagatc taaaatacta agctctccga tctcccgttt gcccatgaaa cgaaaaatga 2242921 ccaatatcac aaaatacaat acgactgtgc gaaacgcaat agtgagaagc tcttccatta 2242981 tgcacctcca actcattata ggttgcaaca aaatgatcaa tttatgtaag aaaaaccgat 2243041 tgcatttcac aaagctttta cgtctaattc atgggataag ggaatacatt tttacaaaga 2243101 cgagccatca gcatgtctga cggttttgaa caaaaagaac agaagccttt taatacaggc 2243161 agagaggaga caatcatgga ggaaacgaaa caagttggaa aaggcattct ttacggctta 2243221 atcgccatat tttcagccat gctcctgaca agtttagcgg tttcactttt attgaccgca 2243281 acctcgctgg aagaatcatc atttaactgg ctgatcaccg ctatctcatt tctctcttta 2243341 tttatcggcg ggttcatttc aggcgggaaa ggcaaggaaa gaggctggat gattggcgca 2243401 ttgaccgcct taagtttttc tctgattatc ttattgtttc agtatttagg attcggaaag 2243461 acatttacag cagaacagct gatcttccat ctgggatttt taggggtgtg catgctgggc 2243521 gggattttcg gcgtgaacat gaggggaaac aggtcttcca cataaaaaag agcgggctca 2243581 cttgcccgct cttttttgtt tgctatgtat agctcctgct gttattcagc agcagaaact 2243641 tctctgatcg cgcggcggtc gaacgtaaga cgtgtgttat caccagtctt aattacgact 2243701 ttgctttcgt cgatagagtc aacagtaccg tgcaatcccc cgattgtcac tactgaatcg 2243761 ccttttttca gttcctcttg catttggcgt acagcctttt gctgcttttg ctgaggacga 2243821 atcagcaaga agtaaaggac cgcaaacatt aaaataatag gaaccaatgt acctaaagtg 2243881 ccagtcatca ttttcacccc tttctgtaag cctgttatgt ttatttagaa gcttttcgca 2243941 tttggcttgt tatagccgta acgctcaaag aactcttctc tgaaatcacc cagacgatcc 2244001 tcgcgaatag cctgtcttac ctgctccatt aagtgtaaca gaaaatgaag gttatggtaa 2244061 gttgttaatc gaaggccgaa tgtttcattg cagcgaatca agtgcctaat gtacgcgcga 2244121 gtgtagtttt tacatgtata gcaatcacac tcttcatcaa tcggacggaa gtctctttca 2244181 aatttcgcat ttttcatatt gagtcgtcct tcagcagtaa acactgtgcc gtttcttgca 2244241 atccgtgtag gcagcacaca gtcaaacata tcgaccccgc ggatcgctcc gtcgatcagt 2244301 gcgtccggag aacctactcc catcagatat ctcggtttat ccttcggcaa gagcggtgtt 2244361 gtgaattcga gtacacggtt catgacatcc ttcggttcac ctacagacaa tccgcctata 2244421 gcatatcccg gaaaatcaag cgaaatcaag tccttcgcac tttgtgtccg cagatcttca 2244481 tattctccgc cttgtacaat accaaacagc ccttgttcat cctgacgatt gtgggcattc 2244541 aggcagcgtt ccgcccagcg gcttgtccgt tcaactgacc tcttcatgta gtcgtactcc 2244601 gccgggtatg gcgggcattc gtcaaacgcc atcataatat cagagccgag tgcgttttgg 2244661 atctccatcg ctttttccgg agataaaaac agcttgtctc catttagatg attgcggaaa 2244721 tggacaccct cttcctctat attacgaaac ttgcttaaag aaaagacctg aaaaccgcct 2244781 gaatctgtta aaattgcgcg gtcccagttc ataaatttat ggagcccgcc cgcttctttg 2244841 acaatgtctt ggcccggacg aagccataga tgataagtgt tgctcaaaat gatgcctgca 2244901 tccattgctt tcagctcttc aggcgacatt gttttgactg tcgccagtgt gccgaccggc 2244961 ataaaaaccg gcgtttcgaa ggagccgtga ggcgtatgca ctttgcccag ccgcgctcct 2245021 gtttgtttgc attcttttat aaattcatag cgtattggtt gttcagccac ttttgatgag 2245081 gcctcctgtt ctcaaattat ataatcagca tcgcgtctcc gaagctgaag aaacggtatt 2245141 cctcttccac tgcatggtta taggcacgca gaatgttttc tcttccagca agcgcgctga 2245201 ccagcataat caatgacgat ttcggcaaat ggaagtttgt aatcattccg tcaatggctt 2245261 taaattcata gcccggataa ataaaaatag atgtccagcc gcttgatgct ttaaattgcc 2245321 cgtcatgttc tccggcaatc gtctcaagcg tgcgtgtcga ggtcgtgccg acagaaatga 2245381 tccgaccgcc attttctctt actttgttta aggctgcagc cgtttcttct gacatttgat 2245441 aaaactctgc atgcatatta tgctcttcca cttcatcggc actcacaggg cgaaacgttc 2245501 caaggcctac gtgcagtgtg atgaactcaa tttgcacgcc tttgtctttc agctgctgta 2245561 agatttcttc cgtgaagtga aggccagctg taggcgcagc agcagagcca atttcttttg 2245621 aatacactgt ctggtagcgc tctttgtcat caagctgttc tttgatatat ggagggagcg 2245681 gcatctctcc aagggattca agcacctcgt agaaaatacc gtcatattga aattccatct 2245741 ttctgccgcc gtgctcaagc tcttccgtgc agattgcctt caatcttccg tctccaaatg 2245801 tgacaacagt tccttttttc acccgtttcg ccggtttggc aagtgtttcc catttatcac 2245861 cggtttcctg tttcaacaaa agaagttcca ctttcgcgcc ggtatcctct tttgtgccga 2245921 ataaccgcgc aggcagtacc cgggtattgt tcaggactag acaatcgcct tcgttaaaga 2245981 agctgataat gtgtttaaac gagctgtcag taagctctcc tgtatgttta tcgagcacca 2246041 tcagccttga agcatcacgc tgctccaacg gtacttgtgc aattaaacgt tctggtagtt 2246101 caaaatcaaa taaatcgact ttcatgatga tttcaccttt attctagtct tttgttattt 2246161 cattctgcca aaaagattaa gcaaaattga taataccaca cttataataa tacaagtgac 2246221 aaccgggaag aaaaacgtaa catttccttt ttttacaaaa atatctcccg gcatcttgcc 2246281 gacaaaatgc aaaactgctc cgataataag caaaacagca ccaagaatca taatgatctt 2246341 aggaaattca gtcatatcgg ggagcctcca tttggaaatg atgataaacg gccggtgtca 2246401 cgatccttcc acgcggcgtt ctttgtataa atccaatttg cagcagatat ggttcatata 2246461 cgtcttcaat cgtatgcgat tcctcgccga tggtagctga aatcgtatca aggcctactg 2246521 ggccgccgtt gaatttttcg atcatgccca tcagcagctt atgatcaata tgatccaaac 2246581 cgaggcggtc aacctgaagc cgctccagcg cattctgaga aatgtcttcc gtaatcctgc 2246641 tgtcacccag cacttgggcg aaatcgcgca cccttctcag caggcggttc gccacgcggg 2246701 gcgtccctct cgatcttctt gcaatttcaa gagccgacgg tttatcaatc tcaacctcga 2246761 atacatcagc ggttcttgtg acaatatccg ccagttcttc ttgtgtatag tactcaaggc 2246821 gagacattac gccgaatctg tctcttaaag gagccgtcaa aagccccacc ctcgtcgtgg 2246881 ctcccaccag cgtaaaaggc ggaaggtcga ggcgaaccga gcgggcagat gggcctttgc 2246941 caatcacaat gtccaggcaa aagtcttcca ttgcaggata aagcacctct tcgatcgatc 2247001 tgtgcagcct atgtatttca tcaataaata atacatctcc cggttccagc gccgttaata 2247061 tagcagccaa atcaccaggc ctttcaatcg caggccctga tgtcgtccgc aattccactc 2247121 ccatttcatt agcaacaatc gaagcaagcg ttgtttttcc gagtccgggc ggcccgtaca 2247181 gaagaacatg atccagcgtc tcctgtctca ttttcgccgc atctataaac acgcgcaaat 2247241 tttcttttac cttatgctgc ccgatatact gtgccagatt ttgcggcctc aggctttgct 2247301 ctatcactga ttcatggttg tctgcttcac ttgagacgag ccgttcatcc atgaacatca 2247361 ccttacttta atagtttttg taatgctttt ttcacatatt ggtctgttgt cagcccaatt 2247421 tcttctttaa ggtgaggaag cacctttttg atttcttttt cagcatatcc gagaaccctg 2247481 agggcttcaa gtgcttcttc aagagccgtt tccgctgttt gcttttcaag cctttcttca 2247541 tgattaaaca gattttcaat catttcaggc acaacatctg ccagctttcc ttttaaatct 2247601 agaataatct ggcgtgcggt tttctttcct actccaggaa acttgaccaa aaaagcttca 2247661 tcttcatttt caattgcttg gatgaccgct ccgggatcac ccgagcccaa gatggcaagt 2247721 gctcctttcg ggccaattcc ggtcacgttt aacagctttg taaagagcgc cttctcctct 2247781 cttgttgaaa aaccataaag cgaaaaagca tcctctctga tatgatggta tgtaaaaatc 2247841 gtttcttggc ttctctcctt atatataaac ggattcggcg tgaaaatctg atagccgatg 2247901 ccgccgttct ctatgacaat atattgggga gatacataat caatcgtccc tttaacaaat 2247961 tcaatcacgc aaattcacct ctttgactgt tcttcattgt accataaaaa cagccaaagt 2248021 cttatagaaa agttaacata tgttcgcttc tctctcattc tttcacgaaa aaaaagacat 2248081 gaatacatgt cttcaatcag cggacgctac ccgctgtatg tcttcatatg ttcgatgaca 2248141 tcctcaaact ccgcttttgt ccgaaatgga atgcctttca gcagattttt ttgcatatgg 2248201 ctttccagcc tttctaaatc aatttgaaaa aaagactgaa ttggttcgga agctggctca 2248261 ggccgcccat gaaaagtgga aatcactcca ttatccgata caccgatata cccgttgacc 2248321 ttgctgagcg gagaaatatc gtccatttgc ttccggaaga gcacatatcc ctttttttgt 2248381 tccactagcg tccatccggc ataagctgcc caaaaatcat ccatagaaaa cactttttca 2248441 tgcttatgct caatgctgac atcgccgtcc aaatacacct tttcaagctg cacatgcacc 2248501 tgcagcggct catagtgctc cacttccgcg ccaagtgcgc gggaaggagc tcctattaaa 2248561 aatactgccg ctgagcaaag aatgcccagc aaaagatacg ccgtgctgaa tcgtttcacc 2248621 ctctacacct ctttgcacac gtttatgatt agtttgacca aagaggctac tgcttaaccg 2248681 ttttatcaaa atttgtctgc acattttccc tgacaaaccg ttcctccgta tacacatctg 2248741 tgctttgctc agaaattgtc aagaatcgcg tcagaaaggc actgaaaaaa tacaatgccg 2248801 caaagatcca aatcacgcca cctgcaccga gcggcccaat gaaaagactc acgatgcccg 2248861 gcgcgataaa cgcacataaa ccagatccca aattcaacac tgacatggca gcacctttat 2248921 tatcaggtgc aagcgtcggc aaaagcgcgc ttaatgggac gtaccctgct aaagccgcgc 2248981 cgtagcagca ggcgataatc atgagcaccc aatactgatg cccgatcagc tgaggcgtgt 2249041 aatacagcgc cagcgtaaaa ataccgcatc cgacaccgcc aaaccacatg accgtattgc 2249101 gccagcctag tttatctccg actgcaccga aaatgatatt aaacacaata ttcacaaaaa 2249161 acagcgtccc ccatatttgc agccattccg aaaccgaata cccgtatcgt gctaaataag 2249221 taggaagaaa gatggcaaat ccaaattgtc ctatcgcatt aatcgtcttg accactccgc 2249281 cgatgcctac cttagggttt tcaaacataa tcgtaaatgc cttcgacagt tctttccatt 2249341 tcggctgatc ttgtttttgt atcggagtaa atttatcttt gttaaaaaat aaggcaagaa 2249401 ttccgcctgc cgccacaaac agtaaagcgc tccaaagcgt attgatttct ccaaaggccg 2249461 gaactgcata gctggaatag aacggaccga gcacgttaag gccgcacgta aacataaacc 2249521 aaaaccagcc gacggctttt ccaagaatat tttgagaggt gctgtatgac acccatacga 2249581 gaaaagagta tgcaaacagc ggatatccca agcctctaag agcatagctg cccaagagag 2249641 ccggataata catatgagga atcgcccagc cgataaaagc ggccgaaccg aggataaatg 2249701 caagcaatcc gacagtcatc gtttttctcg gcccccaagt ttggacaaac gttcctgaaa 2249761 gccaagctga gatggtgaca gcaatgccgt acatggtaaa taacgatgcg gattgctgca 2249821 tactgagacc atgatcaacg agaaaaggag acagccagcc ttgttcgagg ccgtctccaa 2249881 ccataaagat gacaacgcca atataacccc aaaccatgtg agaaggaatt ccgattttgt 2249941 tcaaaacatt tcctttagca tgtactgtat tcattttctc caccgcctac ttaaagtatc 2250001 aatggagtat atacccaagc ttgctgaatt gtaatcctgt tagattaaaa agcgattttt 2250061 tcagtgtgct caatgctaac aggcatgcca aaagcaagcg attgctgtgc tgctctggcg 2250121 atcctcccgg cctgtaaacc gtcattgccg gtgcagggag tctcctggtt tgtgccgatc 2250181 gcttctgcaa aacggagaat ctcctcctca tatgaatcct tatagcgttc aaggaaaaag 2250241 aaatgcggtt tatccttcat cacaaaatca gctgttgaca cctcaaccgt tgtcggcctg 2250301 ctattgtcag ccgctgcaga gcctttcgtc ccgaaaacct caacccgctg gtcatatccg 2250361 tacacagctt ggcggctgtt atcaatcaca gccatggcac cgttttcaaa agtcagtgta 2250421 ataacagctg tatcaatatc acccagctcc gcaaaagaag gattcaccaa agccgcccct 2250481 ttggcataca cttccgtcac ttcgcttccc ataatatatc tggccatatc aaaatcatgg 2250541 atcgacatat ccataaacaa tccgcctgac gtacggacat aatctatatt cgggggttct 2250601 gggtcccggg acgtgatttt taataaatga ggtgtaccga tttcaccatt ttcaacaatc 2250661 gttttgattt tcttaaaatg aggatcaaag cggcggttaa atccgacttg aagtgttacc 2250721 ccgtgtttcc ggacagccgc aagcgcttca ctcgtttcgt ccagagagaa actaacgggc 2250781 ttctcacaaa atatatgctt tttcgcctcg gctgcttctt tgatcatctg tgcatgtacg 2250841 gctgtaggag agcaaataaa aatagcatca atatcaggat catgtaataa atcacgataa 2250901 tcagaggtta tgtattcaat ctgatgactg tcggcccagc tttttatacg gctcgcctga 2250961 atgtcagaga ttgcttttat tttcatgtga ggaatccggc ttatattttg aacatgaagt 2251021 ttgccgatgc ggcctgcacc gataatccct gtcacaatct gttttgtcat ggcttcttcc 2251081 cccttgatca ttcacgaaag cgctttattt aaaattaata ctatcccatt tgtaagcgct 2251141 tttcaagaat ggaaattaaa cgttctatgt ctcttttatc acaattcatg cttataagta 2251201 gccttcttct tcaagaccag atacactaga attaggctct ttttcctgaa cagtttatga 2251261 ttttcctata aacagctgca taaaatagag caaagaaggt gaatgaaatg ctgacaaaag 2251321 cagaggcact ggcccatacc gtcatatacc gcaagaacag cagatttgat aaagtcaaag 2251381 agaaatccga ggaattaaca ctaatcggca agggaagaag cgcctatgtg tttgccttaa 2251441 cagaaggcgg tcgaaaaatg gcgctgaaag tattttttcc ggaatatcaa gcgacagcag 2251501 tcaaagaagc agcgatctat gaaaaattag ccgggtccgc attctatcct gacatttacg 2251561 aaactggcga ttcatttatt ctcatggaat atattaaagg tgaaaccttt tataactgtc 2251621 tgaagaaagg cattgcaatc agtgatgaca tgattcagca ggttgaagaa gcgctttctg 2251681 acgcccgggc agccggactg aacccgtcag atattcattt gcggaatctg atattgacag 2251741 aaaccggggc ggtgcgggtg attgatgttg cgagatttga gcagacaaaa acatgcacgc 2251801 agtgggacga cttaaaatcc gcatatcatg cactctacaa aaaaccgata ttccccaaaa 2251861 agattccggg tttttggctg gagatcatcg catttttata taagaaagat tggtttcaaa 2251921 agcatttcgc acagcggaaa agaaaatatt cttaaatcaa aaaggcagcc gcacaagcgg 2251981 ctgcctttat catgtatttt ttactttctg acggcagaaa tcagtttcat ttgttcaggc 2252041 gacagcttaa ttcgatagcc tctcacagtt aagtagaccg cttctgggtc cttctcgccg 2252101 gaatgacaat acgttttttc catttctgtc tcccctcacc ctttattggc tttatttcat 2252161 cttatcattg ctttattgag gtaattttaa agaaatgtaa agattatatg aatccgatat 2252221 atagtaaaat gagagaaaaa aagggagaga gtcacattaa gaccgaaaac accttgagct 2252281 tagatgcagc cagaggtgaa cttgtaaatg aaaaaacact tgtcaagaga acaatctact 2252341 ggaattaccc ggacagccgc ccagcagtga cgtggatcaa tcacaataca gtgaaaatcg 2252401 gcaatcagac tttacatctt gatactgatg aaacgtatga ttggcgaaaa gatgatcatt 2252461 ggatccgtga agaaccgccg caggcgtcag tgaggtgatg aaacatgaat aagatgaacg 2252521 gaacaaatga tgaaaagcat ttcaatcatt ttgtgattgc tttatccttt atatacggtt 2252581 tgactgaact aggctatttg ttgctgaagg attttataac aattgccata agtttgcctc 2252641 tgtagaaaaa cgcagcgtag tcgatacgcc gcgttttttc tttttccctt cctcttctta 2252701 ttgataatta caggtcatat aatgtgacaa atcgattgta gaaatagttc gattagacca 2252761 aaatcctttt tatacatgta ttcgaatttg aagtgagggg gaagcttgat ggcagatttt 2252821 gttgctagtt tgaatgcggt cttatggagt acgcccgtca tttatatttt attgggaatt 2252881 ggattcgcct tttcaattat gacccgtttt ttacaagtcc gacatttaaa agaaatgatt 2252941 gttcagatgt tcaaaggcaa gagctctgaa gccggcgttt catctttcca agcgttatcg 2253001 attgcgctgt ccggccgtgt gggcacagga aacatcgcgg gagtggcgac agcaattgca 2253061 ttcggcggac ccggtgcagt gttctggatg tgggcgattg cctttatcgg ggcggcgagt 2253121 gcctttgtag aatcaacgct tgctcaaatt tacaaagtga aacaagacgg tcaatatcgg 2253181 ggcggccctg cttattatat agaaaaaggc ttaggcatta agtggtttgc cgtcttattt 2253241 gccgctgctg cccttattgc aatggccttt ctaatgccgg gcgtacagtc caactccatt 2253301 gcggctggga tccaaaatgc attcggcatc tctcctttcg tcacagggtg cggtctggtt 2253361 ttattattag ggttcattat ttttggcggc gtcaaacgaa ttgccaatgc ggcgcaaatg 2253421 attgttccat ttatggccat tggatatatc ctgctgtctt tgattattat tgtcatgaat 2253481 gtgtctgaat tgcctgctgt gatctcatta atattcaaaa gcgccttcgc attggattcc 2253541 gcttttggcg gcttgatcgg tatggcgatt tcctggggcg ttaaacgtgg catttactca 2253601 aacgaagccg gccagggaac aggcccgcat ccggcagctg ctgcagaggt ttctcatccg 2253661 gtcaagcagg gactggttca ggcattttct gtttatattg acaccttgtt tgtatgttcc 2253721 gctacagctt tcatgatctt gtttaccggc atgtacaata cccaggctgc agatggttcc 2253781 tttatcgttc accagcttaa aggcgtagaa gcaggacctg gtttcacaca agcggcaatt 2253841 gacagtgttc ttcccggatt cggtgcaggc tttgttgcca tcgctttatt cttcttcgct 2253901 tttacaacaa ttatggcgta ttactacatc gcagaaacaa atatcgccta tttagcacga 2253961 ggcagagaaa gcaaatgggc gatgcttggc ttaaaactga ttattttagc cgccacgttc 2254021 tatggtactg tgaaaacagc ttcacttgct tgggcattag gggatgcagg gcttggcatt 2254081 atggtatggc tgaacgtcat tgccattgtg ctgcttgcca agccggcgct ccttgcttta 2254141 aaggattatg agcgccaaaa gaagcagggc ttagacccga tctttgatcc aaaagcgctg 2254201 ggtatcaaaa acgctgattt ctgggagaaa gaatacactc atgaaagtga acgtgtctcc 2254261 tgaacatact aaaaccggcc cgatatgacc tcgtgccggt tttttatgaa cgatagtttg 2254321 tatacacttc ttgaacatca tcgtcatctt caaggacgtc tattaatgtt tccagcttct 2254381 caacagcctg atcatcggct tctgcatagg tattgggaag catggtcacc tccgccgaag 2254441 aaattagata tttcgattcg agggctgttt tcacctcttc aaaatgctca ggctctgtga 2254501 aaacctcata taggtcttct tcaattcgca gctcttctcc tcctgcttca agcacatcaa 2254561 gcatgagctc atcttcttct atttgccgtt cagtacggtc tatcgtaatg aacccctttc 2254621 gttcaaataa aaaggctaca catccgcttt ctcccagact tccgccattt ttattaaagg 2254681 ctgtccgcac atttgacgcc gttcggtttt tattatctgt tacgcattca accatgacgg 2254741 caatccctga agggccgtag ccttcatagg tgatttcttc atagctgctt ccgtcttggc 2254801 ctcccgcagc ttttttaatg gcccgatcta tattttcatt cggcatattg gcgccttttg 2254861 ctttttcgat gacaagacgc aatgctgaat ttgcttctgg atccgctccg ccttctttcg 2254921 ctgccacata gatttctttt gccagcttca taaatatttt cccgcgcttt gcatcctgtg 2254981 cattttttct tttttgaatg tttttccact tggaatggcc tgccatgttt tcaccttctt 2255041 ttacattttc tatgtacact ttaatgggaa atgttcgctg atgcaaagaa aaaggctgcc 2255101 gaatatcact tccggcagcc cttccttcct agcggttgtt cattttatga agttttctga 2255161 acagcccttt atctgttgat acttggacgt cacggccatt tgcatagttg cgcgctgctt 2255221 ttacaacatt atctctgtca gactttgtga actctctgtg gcttttgact gcgataacta 2255281 ctcggtcatc cgataccata acttgtgtgt cattgacgtt tttcacttgt ttcacacggt 2255341 tggcaatttt tgcagccagt cttctgtttt cttggttgtc atacccgttg ttcgctgcat 2255401 tccgattcat gtttcggtta ttcgtgttgt tatatgttcc gtcagttgcc aaaggaacac 2255461 gatcgtcagc agtaacacgg tcacggttat ttacattcgt ggtgtttcgg ttaccgtcgt 2255521 tctgatcctc cattaattca gaaacaggac catcgtggtc gattccgtct ccctgtctat 2255581 cggcgtcatt ttcatttgta taatatccga ttggacgggt attgccgtta ttgcgcgtat 2255641 cattcatagc attatcgttt gctccgcatg ctgttaagcc ggctgtcatt agaatcaggc 2255701 tagcgatcgt cattttttta cccaatggaa aaaccccccg tggacgaatt gagcatgttt 2255761 gctcgctttt atcatgtgcg tatggggggc atgttaagcg tgtcagttct ctccatttgg 2255821 cagtgatctg cttgaaaaca aaaaaaggaa cgatttacat cgttccgaac gatcactcat 2255881 tttcttcttc cggacggcca aacatttggt ttacagaagg ctggttcgtc attggcatag 2255941 aaactcctgc cgaatatggg tttggatttg ggttagctgt gccatatggc atattagggc 2256001 ttccataagc tcccattccc gaatggccag gtgcagagaa atatggctga tgatcaccgt 2256061 cacagccgca gtcgtcatga tctttgtatg gcatgtaacc atgagccgca gcaggctggt 2256121 atgctcccat tacttgggga gtgccgtaat aagggccata cggcatatgt ccatacggag 2256181 atccataagc cggagatgcg tattgcggcg caccgtatga accgtaatgt ccgtgatggc 2256241 tgttttcatg atgctggttt tcataacccg ggtcatactg aggcgataca aagcctggct 2256301 ggtatccatg catcggatgc attggataag cttgtgccgg atagtacgga tagcataatc 2256361 ctgatcctgg aagaattggc gaaacaggca ccggacacgg tacgaaatga gccggataat 2256421 gataataagg ctgaacagcc ggcatcggca tattcggaac tgtgtgatga acgttttcct 2256481 cttctatacc gcctacctct ggcgcctttg gcatattagg catattcgga taatttgcat 2256541 tttccatatt actcatagcc tcctgttgtg gaaattggtc ttgcatatga tacatatgat 2256601 ccatatttcc gtcatgatgt tttttcggct cctccggttt aggaggcgac caaggctgga 2256661 aaagctgttt catatcataa taatcgttca catcagcttc agggtacaca ttttcctgca 2256721 aattaggcat cggcgggaca tacggcatgg acttcttttc tttcggcttt gtgtcttcta 2256781 catcgacaac ggatttaggc ttctctttcg catatggatg ttcttgcttc acactcccgg 2256841 ccgcaggact tttgcccgct tttggctctt ttctgaccgg gactccttct gacggcactt 2256901 ttattttcat tccaggcatg attaagtctg gattgctaag ctgtgtattg agttttttca 2256961 cttcctcaac atcgactccg tacttttcag ctattttcca gagcgaatcg cctttttgaa 2257021 cgatatggat tttcaacgtt ttcccctcct atgcaaaacg tgaacagttc agctgtgatt 2257081 acaatatgtt tcttcacaac atatgcctga acaaaagaag ttatgagtaa aggaagggaa 2257141 aatatttctg atctacgtga tcgaaagcat tcgattcagg gcaaggagtg catcttcctg 2257201 aatggctttt ggcaccttga tgacgcctga aggttctcct ttttcaattt gttccagcga 2257261 ccacaacaaa tgcggcaaat caattcggtt cattgtcagg caagggcaca tgtcagggtt 2257321 gagtgattcg atttgtttat ctggatgctc gtgaatgatc cgctgaacaa gattcatttc 2257381 tgtcccgatt gcccacttgc ttcccgccgg agcctggttg attgtgtcga taatatattt 2257441 cgttgatccg ttatcatcgc ttagtgtcac gacttcgtgt gaacattccg ggtgcacaat 2257501 gatctgaatg tcggggtctc gctctctcat atcatggata tttttagtgg tgaatttctc 2257561 gtgaacagag caatgccctt tccacaaaat cactttcaca ttcgtatgcc cggattcagc 2257621 tactaattca tctttcatcg gatcccacac agccatatct tcaagcgcaa tgcccagatc 2257681 ataagccgta tttctcccta aatgctgatc aggcaaaaat aaaattcttt ttttctgtgt 2257741 aaacgcccat tcaagcactt ttttcgcatt cgaagaagtt acagttgctc cgccatgctt 2257801 tccgacgaat gccttgatct ccgcagtgga gttcacataa gttaaaggta tgatcgtatc 2257861 tccaaatata tgctgaagct tcttccatgc cctattggtc tgctgcatgt cagccatgtc 2257921 agccatagaa catccagctc tcatatctgg caggacgacc gtttgctgct cgcttgtcag 2257981 catatcggcg gtttctgcca taaagtgaac gccgcaaaat acgatataat ccgcttcttt 2258041 gtttttttcc gctacttggg ccaattgcag ggagtcgcct gtttggtcag caaattgtat 2258101 cacttcatcc ttttgataat gatggcctgg tataaagagc ctgctgccga actttttctt 2258161 aatggcggca acgcgcgttt ccatatcctt tctcgatagt tctttataac tttcgggcat 2258221 catatcattc gattgtttga tcacatcaag aattgacata acagcattcc tccacagatt 2258281 catttgataa cgtaacatcc atgctgatat ctaaactttt gacggaatga gtcagaaatc 2258341 ctaatgaaat ataattcaca cccgtccctt taaaagcagg caaagattct aacgtaatcc 2258401 cgccagaggc ttcagttttt atattagccg gtgtgagctt tgcaaaatga cggaccgtat 2258461 caggcggaca gttgtcaaac ataataacat ccgctccagc tgcaattgct tcccgcagct 2258521 gttcctccgt ttcaatttcc acctcgatat ttaccatgtg ccctgcggcc tgacgggctt 2258581 ttttgcacgc ctctaaaata gagccgcatg ctgcgatatg attatcttta atcatgatgc 2258641 cgtcatacaa accgaatcga tgattatacc cgccgccggc tctgacagca tatttctcca 2258701 gcattctgag ccccggtgtt gtttttctcg tgtcacaaat tttaatctgt tcatcatcca 2258761 gacaccgaac agcctctctt gtcattgtcg caattcctga cagcctctga ataagattta 2258821 atacgacccg ctctcctgaa aggagcgcag ctgcgggacc gtgtaactcg gcaatcactt 2258881 cacctttatg caacatgtcc ccatcttttt tgtgtaaaat gctttgaaca ttttcgtcca 2258941 ataacgaaaa gccttctttt atgatcgctg ctcctgcaaa aataccctct gactttgcaa 2259001 caatctccgc ttcacagctc tgttctccaa aaatagactg cgatgtaaga tcccctgtcc 2259061 caatatcctc aagaaaaaag tgattcagta attttttcag ctgtaaatga ttcattgttc 2259121 caaatcccct cgttttttct gatcttcgtt cctttttttg tatggacaat ttgtcttcct 2259181 tgccagctca cctcagcatg aggaaaatcg gtgcggaagt gagcccctct gctttcctcc 2259241 cgcaaaagcg cagaaaacgt catcagcttt gcagtttgcc atagatgaga aagttccatc 2259301 tgccgaattg tgatatcctt cacatttact tcctgaaaag gcagcgtatg aagccagatg 2259361 ctaagctcaa tcaaactgct ttgttcccgc agaatagaca tgtggcttgt cattttgctt 2259421 tgcagttcat gcccctctat atccggcacc tcgtagaaga cactggtttc tagccctgat 2259481 tgatattgcc tgttataaac cggtttttgg ataatatgct ctgctgccct ttttccaaat 2259541 accagcgctt ccaataaaga attgcttgca agccggtttg ctccatgtaa accggagcat 2259601 gctgtctcgc caatcgcata aagccccggc actgtcgttt ctccccagcg attaactgaa 2259661 acacctccca ttaagaaatg cattcccgga gcaacaggaa tttttccgct gtggatatca 2259721 atccctgctt tttcacaaat agcggtgatg gtagggaaac gcgtttcaaa atcagaaatc 2259781 gcactgaagt ctatataaac gcgatttcct tttgccattt cttcgtgaat aacccgtgag 2259841 acaatatctc ttggagccag gtcacctaaa ggatgccgtt cagccataat cctgcggccg 2259901 ttttcgtcta ctaaacatcc gccttcccct ctgacagctt ctgaaacaag cccgtaggaa 2259961 acaccatttt tcacaagcag tgtcgggtga aactgagtaa actccaaatc cgttaattcc 2260021 gccccggccc ggtaagccag agaaagaccg tcacctgtga cagtgagatc attcgtatgg 2260081 tgaagaaaca ggtttccaca gccgccggca gccagcacaa cttcgtctgc gtgccttacc 2260141 ttgagccgcc ctttgctgtc ttttgtcatg acgccgatac atcgtccgtc ctctataagc 2260201 aaatctgctg ccgtttcatt ctcgattaac ttgattttgc tgttgatccg tttgagcaaa 2260261 taatcgataa gcagcctgcc tgttgcgtct ccgcctgcat gaaatatgcg gttgtatgag 2260321 tgggcccctt ctcttccaag acaaacaccg cctcgttcat tgcggtcgaa tggaaatcca 2260381 cgctccaata ggctttgaac catcattttt ccatcatgta atacgtctgc tacaatagct 2260441 agattattat ggccgcaccc tgcgtataac gtatcctcca gatgggcttc aatcgagtca 2260501 tcttttgcat aggccgcagc aatcccgcct tgtgcataga cagaattgct gtttttgacg 2260561 cttttttttg tgataacagt cacttcgtat gagggcggga aagctgcagc taaggaaagt 2260621 gccgccgccc ctgaaccgat gactgcaatc gtctttttag acatatgcca tcctcctgtt 2260681 gtttacacct gtcttgacac ctatatttac acaaggataa aataaactca agagtttttt 2260741 atggagaacg gatggaggaa gaccggatga tttatttaga ttatgcagcg acaacgccta 2260801 tttgtgagga agcccttact gtatatcaga agcttagtat ggatatgtac ggaaatgcca 2260861 gcagcctgca tgatgcagga ggaaaagcaa agcacatact ggagtactgc cgtgaaaaaa 2260921 tcgccaacat cattggcgga gaagcaagcg gcatctattt tacaagcggc ggcactgaat 2260981 ccaattttct ggccattcaa tcattgttaa acggcctgcc aaaaacgaaa agacatttta 2261041 ttacgactgc catggagcat cagtccattc ataattgcgc tgcttttttg gaacagcagg 2261101 gatatgatgt aacagtcatt gaaccgaatg aatacgggct tattaccgag gaaatattac 2261161 taacccatat ccggccggaa acaggccttg tatctattca gcatgcaaat tctgaaaccg 2261221 ggatcattca gcccattcaa cacctgtctt catacctgca caataagggg attcttcttc 2261281 attgcgacgc tgttcaaacg tttggaaaga tcccgatcaa tacaaaaaat ctgggagtag 2261341 atgcactctc aatgtccagc cataaaatcc acggtcctaa aggagtaggg gcggtctata 2261401 tccggccgga tgtcccttgg aaacccgttt atcctctgac tactcacgaa tacggattca 2261461 gagccggcac cgtaaatgtt cccgggatcg gtgccttcac tgccgctgca gaattgatcg 2261521 taagcgaaat ggaaaaacag atatcccgca atgaggcatt aagaacatac tttctagacc 2261581 aaatccgtat tcggtctctc cctgtaaccc ttgcagcaga cacttcgaaa gcagaatgtc 2261641 ttccgcatat tatagggtgt ttttttcact catttgaagg acaatatgtt atgttagaat 2261701 gtaatcggag taatatttgc atttcaaccg gcagcgcttg ttctgcaggt taccacggtc 2261761 cgtctgaaac aatgaaagca ttaagaaaaa ccgaacaaga agctctgcaa tttatccgca 2261821 tctcttttgg caggcataca acagctgaac agctggaaca gttattacat acgtttacag 2261881 tgctttggga acaaaagaaa ggagaatttg atattgaccg aagaattaaa gctaatgggc 2261941 gccaacaggc gtgaccagct tcttctgtgg ctgaaggaat ctaaatcacc gctgacagga 2262001 ggagaactcg caaaaaaagc gaacgtctca agacaggtta ttgtacagga tatatcgctc 2262061 ttgaaagcga aaaatgtacc gattatcgcc acaagccaag gatatgtata catggatgca 2262121 gccgctcagc agcaccagca ggcagaaaga atcatagcat gtctgcacgg tcctgaacgg 2262181 acagaagagg aactgcagct catcgtcgac gaaggcgtta cagtaaaaga cgtaaaaatc 2262241 gagcatcccg tatacggaga tttaactgca gccatccaag taggcacccg gaaagaagtt 2262301 agccatttca tcaaaaaaat caattctacg aatgctgcct acttatcaca gctgaccgac 2262361 ggcgtgcacc tgcatacact gacagcacct gatgaacatc gcatcgatca agcctgccaa 2262421 gccctcgaag aagccggcat tttaattaaa gactaaaaaa agccctctag tgggcttttt 2262481 ttataattgg taagactggt atgcacccag aagcctcact ttgcagccga gtgcttcaag 2262541 ctcctgcatg gcccctggaa tcaatacatc atcaaacgct ttctcaatat caataataaa 2262601 gaaataatgg cctaatccgg ttttagtcgg acgtgactca atttttgaca ggtttaaatt 2262661 tctccaagaa aatgcagaca gcactctatg cagcgccccg gactgatcat cctgcggcag 2262721 catgaccatt aaggtcgttt tgggcctaga gctcaatttt gaattcactt caaaagatat 2262781 gttttcatcg ggagacagga taacaaatct tgtatgattg tccctataat cctgtatatc 2262841 ccgtttcacg atttttaatt cgtatgtaga agctgccata tcattggcaa tgaccccgat 2262901 attcagctcg ggatggtcac tgacaaactt tgctgccgcc ccggtagaat tggcgtattc 2262961 atatggaacg gaaggaaaat gtcgatgaag aaatttatgg cattgcgcaa tcgcgtgtga 2263021 atgtgagtaa attttgtcga gctctttcca tgcattctct cttgagggat ggacgagcaa 2263081 gtgctggtga atcggcaacg tcatttcacc cacgattggc aaaggctgtt catgtattaa 2263141 atagtctatt gttagattaa cagatccttc taaagcattt tccaaaggaa caaaagcaaa 2263201 atcaacttcg cctgcaacgg ctgcatctat acactccgga atggtgcggt aagcaacatg 2263261 ttcggcgccg ttttgaaaac aagaactgac tgctagatgt gtaaatgtag ctgctggacc 2263321 taaataaccg actttcatga cgattttctc tcccttatgc acctgaacct aatatttcaa 2263381 ccttttctac aaaatcaaac ttcctgagct tattcattaa tgtatgaatg tcttcttcca 2263441 ttgccgacgt actgatagac agtgtcacat ttgctctgcc ttgaagcgga atggtctggt 2263501 gaatggaaag aacgttgctt ccagaatcag ctaccgcctg aagaagctga gataacgcac 2263561 ctgacctatc ctccaaatga aagaaaagtg tgataatttg ttcttttacc atggtgtaga 2263621 atggaaaaac agcatccctg tatttataaa acgcacttct acttaaatcg accttttgaa 2263681 cggcatctgc tactgaatct gctttttttc gatcaagcag ctttttgact tctaatgttt 2263741 ttctcattgc atcgggcaat acatcttcac ggacaagata aaatgtctcc tctttcattt 2263801 gcatcccccc tttaaaatag agagcctggc accaggctct cttttcagcc aacattgatt 2263861 aatcaataaa ttcaaattca aattccagaa gcctgattat atctccatcc ttggctccgc 2263921 gttctctgag tgcttcatca acacccattc cgcgcatctg tcttgcaaac cgtttaaccg 2263981 attcatcacg tgagaaatca gtcatcttga ataaccgctc aaggctgtct cctgaaagca 2264041 caaatacacc gtctggatcg cgtgtaatgt taaatggcac ttcttcattt tccatcgtgt 2264101 acatgacacg gttttgtgta agctcttcct cgtcatacag cgggaattcc ggtgtgttct 2264161 caagctgatt ggcaacctca aacagaagct cacgcagacc ttctcttgtc accgcactga 2264221 tcgggaatac cggataatca tccgtcagct tttctttaaa ggcttcgaga ttttccgcag 2264281 cctccggcat gtccatttta tttgcaacga taatttgcgg acgctcagtg agacgcagat 2264341 tgtactcgct cagctcctgg ttaatcgtaa gataatcatc atatggatca cggccttcta 2264401 agcctgacat gtcaatgaca tgaacaataa ccctcgtccg ttcaatatgg cgcaaaaact 2264461 ggtggcccag tccgacgcct tggtgtgcgc cttcaatcag ccctggcaaa tcagccatga 2264521 caaagctgcg tccgtcatcc gtttcaacca tgccgagatt cgggacaagc gttgtaaagt 2264581 gatagtccgc aattttcggt tttgcagatg agacaacaga cagcaaagta gattttccca 2264641 cactcgggaa cccgacaagt ccgacatctg caagcacttt taattcaaga acaatgtagc 2264701 gttcttttcc cggctcgccg ttttctgaaa gctgaggcgc gggattagcc ggtgtagcaa 2264761 agcggctatt tcctcttccg cctcttccgc ctcttgcaat gacagcccgc tgtccgtgct 2264821 ctgttaaatc agcgatgacc tgttttgtat catcgtctgt cacaacggtg cccggcggaa 2264881 ctttaatgac catatcatca gcatttcgcc cgtgctggtt tttggacatg ccatgctcgc 2264941 cgcgaatcgc tttaaagtgt tttttgtatc taaaatccat cagggtgcgg agaccttcat 2265001 ctacttcaaa aacgacgtct cctccctttc ctccgtcacc gccggcaggg ccgcctttcg 2265061 gcacatattt ttcacggcga aacgcaacca taccgttgcc gccgtcgccg ccttttacat 2265121 atactttgac ctgatctaca aacataatgt cctccgttct aaaccgttaa aaactccgct 2265181 agtccaaccc aatttcaatc agacattcgt gactcgtgat ttcaaaacgc atgatatcaa 2265241 cgtcctcata tccattctgc cgaatatcat caaaagcaga tggatcggca aaggcgccgt 2265301 gaaaatcaag gtacagaatc agctgtctgt caggatgatc cgtttgaagc gaaaccgtta 2265361 aatgattttc actctctctg ctgactgctt gatcaaacag atgaaacagc tttctcatca 2265421 gtttcgccag cttttgatca taagccgaca aatccttaat ttctccgaga acttcatatt 2265481 caagcgtcat ataatgggtt ttccaattaa acgtaagaaa atcaaacgcc aaatgcggtg 2265541 ttttcaggtt tgagagcttt gattcgtgct ttgcgtctat aaccatttct tcaatcattt 2265601 caaagacacg gtcatacttc tgtaagctta agtttccttt aatcagctgc agcttattca 2265661 tccaatcatg ccgggaatgg ccaagcagat gaatcagttc gtttgttaat gccgtgtcgc 2265721 ttatattttc ttcttgattt tttgaaacat ccttcatttt cgcactccca atcatttaat 2265781 ttcttattta ggagtctgta taagtgtgta ttatgaatta taacagagaa ggctttgtta 2265841 gaaaaacaat tgtttttccc agaaatatca tgttcctttt ttctggcttt ggttgatttg 2265901 cagccaggca gaacatttta tgtattactg cttggggaac atatccagtg ggtttgagat 2265961 gtttattctc attcttggcg gggtctgctc gcacatactc tgcatttcat tctaggtgtt 2266021 tactccgcat attgcaaaaa aaactccagt catcatcgac cggagttttt tgaatcatta 2266081 ttgagctaca ggatatacgc tcactttttt gcggtcacgg ccgaaacgtt cgaatttaac 2266141 agttccgtcg attttcgcaa atagagtgtc atctccgccg cggcccacgt tttcacctgg 2266201 gtaaattttt gttccgcgtt gacggtaaag gatagaaccg cctgttacga attgaccgtc 2266261 agcacgttta gcacctaaac gtttagcctc agagtcacgt ccgttctttg tagaacctac 2266321 tcctttttta gaagcgaaaa actgaagatc taatctaagc atgtagctca cctcctatat 2266381 tatgtttgtg gtcacacgca agttgtcttt gtaatcccgt tcgattgtct ccagcgaaac 2266441 aatcatgcct tcaatcagca gctgagcttt ttggcgtgcc tctggatcaa gagattcagg 2266501 gaattcaaaa taaaaataac ccccgtcctc tcctatatca agaagcggct cgaagcccgc 2266561 gagcacaatg accgcgttaa cggccccaaa cacaacggct gtcactccgg cacaaacaag 2266621 atcttgtcca tgttcagcaa aattcgcatg gcccgtcatt tcaaaagaca atatgccttt 2266681 atcatgagac cttctgattg ttgcctgaat catgcttacg cgttgatttt ttcgatcgtc 2266741 actttagtgt aaggctgacg atgaccttgt tttttatgaa cgtttttctt tggtttgtat 2266801 ctgaaaacag tgattttttt cgcgcggcct tgtttttcaa ctttagccgt tactgttgcg 2266861 ccttcaactg tagggttgcc gactttcacg ttgtctccgc caacaaacaa aacgtcttca 2266921 aaagtaactg tttcacctgc ttcagcagca agtttttcga tgtaaacagt ttggccttct 2266981 tcaactttga tttgtttacc gcctgtttta atgattgcgt acattctctg cacctcctat 2267041 tagactaaga ctcgccagat accagggggc tgtaaaagct cttaacacct gtactgagcg 2267101 gttgtagcaa tggtgctaca tccataacat taaaaaatat accaaaatac aaggcgtttg 2267161 tcaatcagtt ttagtagggc agaagcagtt cctccatgga agaattcgtc cgcttatcgg 2267221 caaagtaagc gtgcagcact tcattctcgt caagctggct gagcttttgg cctgattttt 2267281 ctataataat cggatgctta cagccacgtt tgaactcggc catcacatga tagactttat 2267341 cctccgcctt tactgtcagc ggcagaagtt tctcaagctc cctgtttttt ccgtaatacc 2267401 tttcgaggag aaatctcaca tggatatagt gcctttgccg atattcctca aacaaggaaa 2267461 cagccagaaa gacaaacaaa acccatgcgc tgatttgcag aggaatcacg aataaaaccc 2267521 agcacccgag cagcaggcag aagcagagcg acgtttttag attaagccgg tgagcctttt 2267581 gaaaaggcag ctgtttggaa aacaacaaaa ataacagttt tcctccatcc agcggccaga 2267641 tcggcagtaa attgacaaat aagatagaaa gattataaaa ggtgaagagt tcaaaggtat 2267701 gctgatgaat cactgagact tctgcaagca tccaggcggc aaactgaagc cagatgtgct 2267761 gaagaggtcc ggcaataatg accgcaaact cttcctttaa cggccgattc ccgtgctctt 2267821 ccacttcgac cgttccgcca aacggcagca aaaaaacacg cttgattctc caagaaaaaa 2267881 acacagccag agcagcatgc cccagctcat gaatcaatac aatcaggagc agacataata 2267941 atgctttcat atggcctgtg agcaagccca gcgccgcaat aatccaaaga aaaggatgca 2268001 catggatctt taagataagg tcgagccatt tattcaaatg aaatcacctg aatcggatca 2268061 ataaatttat cgccgtcttt catggcaaaa taatagaccc ctttattatg atcatcaagc 2268121 ttaatcgaac cgagcttttt gcctttatcc acaaaatcat ataaagcaac atccacatct 2268181 ttgagctcgc catagatact ataggtgttg tcagcatgct gcaccttaac cgtcagtccc 2268241 gtttggctgt ctttgctgac ttcaaccaca tagccttctt ttacgctatc aatcttatca 2268301 ctgcttgttt cgactttaat tccttcccca ttgtcctgaa aatcctgctg tactttcccg 2268361 gatgcaggcg cgatcagatc tttgcctact tcaatctgct gttccttatt tttgtgttca 2268421 ggagccagga aagcaagcgg atttccgaat ttggtttcga accaatggct tgctgaagca 2268481 aattgaaatt cagtttcaaa ggttttggct acggcgggtt taatctgact gacgggtcca 2268541 atgtttgttt tataggctat agctgaaacg agaacaaggc aggccgacag aagacatttc 2268601 aggataattg aatctgtttt caccaatggg tgttttccgt tgaatgttgg catgttatct 2268661 tcgtagaccg gaagtgttcc atgcttttcc tgatccgtta ccatcaccca ggacgggggt 2268721 ttctgctttt cagaaactgt ctgagtagag aaacgttttg agccggaaag ctgctttctt 2268781 cttttctcta atcgttttct gatttcatct gctctgtgac tcattgccat catcctttgc 2268841 attcgttggg tttgtacatc atatgtcttg tccatggcaa atattcggtt tagtcaagaa 2268901 caaagcaggc aaaaacaaaa aaaacctgac acagcatatg ctttgtcaga ttcttctctt 2268961 tgattctatc acattaagat cttactccga aaaatgactt aatcttagcc atcattcctt 2269021 tgttttgctc ttcaagcacc tgtaaaggaa cagattcacc taagatgcgg cgggcaatat 2269081 tgcgatatgc aatggaagcg cggtttttag ggtccatcgc aatcggttcg ccatgattgg 2269141 aagctttaat gacttcatca tcatcagcca cgattccgag caaatcgatc gacagatgct 2269201 gtacgatttc gtcgatatcc atcgtgtcac cgtttttcat caggtgattt ctgattctgt 2269261 taacaacgag ccgcggcggt tcaatatttt cctcttgctc cagcagtcct ataatacggt 2269321 cagcatcacg aacagctgag atttcaggcg tagtgaccac aatcgcttta tcagctccgg 2269381 aaacggcatt tttgtaccct tgctcgattc cggcaggaca gtctatgatg acatagtcaa 2269441 attcctgttt gagctcttgg accatgtttt taatttgttc aggagcaaca gctgtcttat 2269501 cgctcgtttg agcagcgggc attaaataga gcagatcatc gaaacgtttg tcttttacga 2269561 gcgcctgatg cattttgcat ctgccctcta caacgtctac cagatcgtaa ataattctat 2269621 tttcaagacc cattacaaca tcaaggttgc gcagtcctat atcagtatct actaagcata 2269681 cgcgcttccc taaaatggct aaggcggtac cgaggttcgc agatgttgtt gtcttaccta 2269741 ctccgccttt tcccgaagtt attacgatag cctcacccaa ttcacattcc tccctcaagc 2269801 cttgttagat caggtcttaa atgagccaaa tgttgaaggc gttcaatgac catatttccg 2269861 tctgtatcta aataagcaca ttccatttcg ttcccttttt gaatgtggtc tggggagcga 2269921 tttaacacat gattgattct taattgtgtc ggaagcattt cagaggcggc gatgaccgct 2269981 tgattatttc cattgaatcc agcatgcgca attcctttca gtgagcccag aacaaaaatg 2270041 ttccctccgg ccctgactgt tccgccggga ttcacgtcac cgatcaggag caagtcgcct 2270101 tttacctgca gcacttggcc tgaacggaca atttttgaaa cagaaataat ttcggcttcc 2270161 tctcttatct gctgtgcttc ttttttagta atgacttcac tgtcaataga atgaacaaac 2270221 aaatctttct ttgacgcaat caattcggtt agctgttcct cttgctcctt atataaaaag 2270281 cgatttccca gcttaacatg aacgctgatt ttctggcctt ttccatcggt atattgttca 2270341 attgacagca tattctgaag accatcgaga agctcatcaa aagaacacgc atcatccaga 2270401 tgcaatgtta gtccattctt tgttcctttt attgttacat attgctgctt tttggtcttc 2270461 acaatattca cctcaacaac atactcattt cgtcaaaaaa agataaaatc ctttttactc 2270521 atctctcaat tctttcttta gactcataaa aaacaatcta aatggcagaa caagaataag 2270581 agctgctgca atatttaata aaattgtcgg tataaaccgg tcaagcacaa atccgttaaa 2270641 cgtcataatg tctttatgaa tcaaagactg aatgccgaat acgtaaaatt cgagcagaca 2270701 gacagccaga actgctatca atatcactac aaatgcgttt gtatgcaaca ctttaaacgc 2270761 ttttgaagcc aaatagcata gccctgcaaa accaaacatg taaacgccta atagacttgt 2270821 atagttcatg tcatatagaa agccaaaaat aaatccgtaa atcatcgcgt gtttttggtt 2270881 gataaaagcc gacatgaata tcaatacaag catcaaaaaa cgcggggcga gcacttggtc 2270941 atctgtaacg aaaggaaaat gcaccaaatc tgtaaaaatg ctttccgcag aaaaaacaag 2271001 catcataacg aaagggagaa ggaaacgttt cacgatcctt cctcctctgt atcgacagtc 2271061 ggcacgtcac ggttaacaac gatcacatta tttaaatctg taaggtcagc cgcaggtttt 2271121 acataagcaa ccttcgttaa tccataggaa tctgactcga tatcagtcac ttcaccgatt 2271181 gtcagccctt ctgggaaaac accgcctgtc cctgatgttt caataagatc gccttttttc 2271241 acgtcttgtt tatccttacg ctcaataatt gtcatcttaa gacgtttttt ctctttgtca 2271301 tatccttcga tcaagccgta gcctttgctg cctttttttc cggaaatttt tgtcgcgact 2271361 ctgttattgc ggtcagtatc gcttaaaagc tgaacagcag acgtaaaatt gttaagtccg 2271421 gagcttttga tcttgccgat taatgcgcct ttttcgtttg taacggccat atctttcgct 2271481 acgttttgct gagtcccctt gttaatggtg acctgtttcg cccaattatc agggcttctg 2271541 gcgatgaccg ttgctaaaat cggcttgtaa tctttaatcg atttgacatg gccaagctcg 2271601 tcacgcaagg atttgttttc ttcttcaagc tcttgaagct tggcttcata ttgtgtctgt 2271661 ccgtcaagtt tttctcttag acgctcgttt tctttgtatg tgttttttaa atcattgatg 2271721 ttctcaaata ttcctgcaaa aaattcggca ggcgtatgaa aaatattttg aaatactccc 2271781 gtcgtatcgc cgatcacttt ctcaggccag gtggtattgc ggccgccctt cagcgaaaat 2271841 ccaatcatag ccaccaatat gataatacac agaagtaata gcattaaccg cttattcggc 2271901 atcgtgttac acctcttcta ttgaactccc gattatctag ttttcccttt gaaaagatgg 2271961 atgtgctcca gtgctttccc tgttccgatc gctacacaat caagcggatc ttcggcgata 2272021 aggaccggca tttttgtttc ttcgctgatg actttgtcca aattgcgcaa aagcgctccg 2272081 ccgccggtta acactatacc tctgtccatg atatctgctg caagctcagg cggtgttttt 2272141 tcgagtgtgc tcttcactgc ttcgacaatt gtagatacag tgtcgcgtag agcgttagaa 2272201 atctcttttc ctgtaatttc aattgttttc ggcaaacctg tgagcaaatc gcggccgcgg 2272261 atttccatgt tgtcggattc ttcaggagct tctgcagatc cgatttccat tttaatcgct 2272321 tcagccgtac ggtcaccgat catcagattg tacgtttttc tgatgtagtt gataatcgcg 2272381 tcatccatct catcaccggc tacacggatt gactgagacg ttacgatgcc tccgagggaa 2272441 ataatcgcaa cttctgtcgt accgcccccg atatcaacaa ccatgcttcc agtcggttcc 2272501 caaactggca gattggctcc gattgctgcg gcaaaaggct cttcaatcgg atacgcgtca 2272561 cgcgctcccg cctgtcttgt cgcatcgata acagcgcgtt cttcaacagc tgtaatgcct 2272621 gatgggacac ataccattac atatggtttt ctggcaaaca tgcctttatt ttttatggcc 2272681 tgattgatgt aatatttcat catcgtcgcc gttgtttcat aatcagcgat aacgccgtct 2272741 ttcatcgggc gaagagccac cacgttgccc ggtgtccgtc caatcatatt tttcgcatca 2272801 tttccgacag cgacaatcga tttcgtatcc gtctgcaaag cgacaactga cggctctctc 2272861 acaacaattc cttttccttt tacaaaaaca agcgtattcg cagttccaag atctatacca 2272921 aggtctctag caccaattcc aaacatatgt atgtatcttc ctttcttaaa gcaaaaatac 2272981 cctaaaggga aaaactcata aactctatta tagcttaatt cgacgaaaaa aaaagtgtta 2273041 caaatatcct ttttccttta aactcacaaa ttttttatcc ccgatcacca aatggtcaag 2273101 cagctcgatg ccaatcaggt ttccgcattc aaacagccgt cttgtcactt caatatcttc 2273161 cctgctcggc gtcggatctc cagaaggatg attatgaaca cagataaagg aagcggcaga 2273221 tcgtttaaac gcttctttaa acacctctcg cgggtggaca atagatgaat tcaggcttcc 2273281 gataaatacg gtgcgtttat ggatgacttg attttttgta tttaagtata aacagacaaa 2273341 atgctcctgg gttaaaaagc gcatatcctc catgacaaga ttagcgccgt cttccgggga 2273401 gcgaataacg aaatgttctt cgttggctaa tttatgaatc cggcttccaa gctcaactgc 2273461 tgccagtatt tgaatcgctt ttaccatacc gattcccggg atgcttgaca gctcttcaac 2273521 cgatgcttcc ttgagcaggc gcagcccgtc aaatgagcgc agcagccggt ttgacaggtc 2273581 caaaacagat tcgtgtttag tccctgtccg caataatata gccaaaagtt catgattcgc 2273641 taagttctcg gctccgactt tcaggagccg ttcccttggc ttttctttca ttgggaaatc 2273701 tttgagtttt aatggcagat cgtgtatgac caagcactcc ttttctttcc cttcccgttt 2273761 atagaaccgt catgccctta tatcaaaatg gcgaagagct ctcattgttt ttgatatagg 2273821 aaggcccatg actgaataat aatctccgtc tattttcttt acaaaaagcg cgcctcttcc 2273881 ttggatgccg tatgcacctg ctttatccat cggctctttt gtttcaatat atgtccaaat 2273941 ctcttcttca ctgagggacc aaaacgcaac ttctgtctta tcataaaaag tctcgctgtg 2274001 attttcagct tgaatgctga ccgcggttat tactgagtga cttcggcctg aaagcctccg 2274061 cagcatagaa gcagcttctt cttgatcctg cggtttgcca agacattcgc cgtcaaggca 2274121 taccattgta tcagcaccga taacgattgc atgcgggtgg agatcagcta cagccttagc 2274181 tttttgtttt gccaaccatt ggacgttttc ttctggtgaa aagtttcgat ttaatttttc 2274241 ttctacttca ctgacaataa tggagtaggg cagctggaga agatcgagga gttctttcct 2274301 gcgcggagat tgtgatgcaa gtattagcgg ttttgtcatg ttcgtcatcc tttcagggtt 2274361 tgcttaagaa aaaaagatac tcgtttatcc taccaaatca cgaggcttgt cacaatttca 2274421 gaaaaataac tttttcatga caaaataaaa aaagcctgtc actaaaggac gaaggctcag 2274481 ggcactatct cttattttac gacggctaac agctcctgct gagccttcca cccggcttca 2274541 gcacttggat cctctaattc ctttaaagcc tgcaaaatcg cttttttctc tcctgtttct 2274601 gacgcttttg tttcaccaag cgacttttct attttctcta cactcgcttt tgtaatgtct 2274661 tcgtcgagaa tcgcctttgc tgcaagctcc gctgtttcct taaaagaatc tgtcatatct 2274721 gactctattg ataaggaaag ctccttgcct ccccaggctt caaaatcact gtcgattaaa 2274781 acctgtccta actgctgtga gacctccttt tcacttgcta agcctgcaat aacatacgta 2274841 tacccgtcat cctttgacag tgacacggcg gaatatcctt tttcggtcaa ttgttctgtt 2274901 aacgtttcgg cgcccttttc atttgaaaat tttccggctt gcacagcgta tgttttgtat 2274961 gtaccttcag tttgtgccgc ttgtttttct gcgcctgagg tttgtttatc agcagaagta 2275021 tcccctgctt ttgccgtttg gctgcctaaa gaatcctcta aagaggccgg tgctgacgct 2275081 tctttattcc ccgatatgtt taacgcgaat aaccctaatc cagtgccaat gacagccgcg 2275141 aaggcaatcg tcgcggccac tctttttacc ggtttggcag ccccggtctt tccttttgcg 2275201 taaagctttg tttttttctt ttgaaaagga ggaacaactt tagggtcctc tttaaacacc 2275261 ttgtcctcct cggaatccca attgaattca tcttcatcag ggtgttcctg ggatgccgca 2275321 acctcttgtt ctgcctgtct tttttcctcc caatttgaaa atgtcatgct tttattcgcc 2275381 tctgtctcag gcgtctcttg ttcgtaaacc gtctcttctt ttccattaat cgtcaccttg 2275441 agggcttttt ctgcggcttt actgtttttt ttattctttc tttttttcaa ttccgcttcc 2275501 tcccttcatt tgcttgaccg ttcttgtcgg cttttcatgc tacacacttt agcacaggca 2275561 aagaaaaaaa gaacaagact tttgtcgcct tgtccaaaaa acgttcgtca aatttttcag 2275621 cagtcagccc aatgccattt tgatataaaa agaaatgata gagtcaccgt ataaataggc 2275681 taaaatgctc cctgcggcta tagcgggggc gaagggaagc ggctgccttt tagcgagtct 2275741 accagtcaga acagctgccg ctccatataa tgcacctatc aaaactgaaa agaaaaaggc 2275801 agctgccagc attttcacac caagcacaaa gccaatcacc gcaaataatt taatatctcc 2275861 tccccctact cccccatggg tgattgcggc aattacagcc agaaacaaaa atccggctgc 2275921 cgcacctaac aggcctgcat accaggaatc aagcggagaa atcaatctcg cggccgccaa 2275981 aaagggaaga aagaaaatca atattcgatt tggaatcagc ataaaatgaa tatctgtcac 2276041 tgcaacaata atgagaagag agataaacac cacagcggga aacagttcca gcgatatgcc 2276101 aaagcgtatt cctgcggcgg caaataaaca cgctgtcaca agctctgctg cgggatacat 2276161 aaaagaaatc ctatgcccgc agcttttaca tttacctttt tgaaatagga atgacaggat 2276221 gggaattaat tctgcaggag ttaatgttcg ccggcaaaac gggcatgatg aacggggcgc 2276281 aataatagat agatgtaagg ggatacggca cccggccgta tagtaaaaag aaccaaggat 2276341 aagcccgaag ataaaaagaa tggatagcat agacaacaca cctttactca ttgagttctg 2276401 gtatggattg tagcaaaatg gacatcctga gctccaattg ggaatattca attttacaca 2276461 tgaaaaaaac ggcagaatct ttttttgatt ctgccggagc cggatgcttt tatttcaacc 2276521 tttttcgaat gtcagaaata aagtaaagag atccggtaat cagcacaatt tcatttgagc 2276581 cctttttact ttctatgaat ttgattacat cgtctggatc ttcactccag cttttattgc 2276641 tgatttcact tgcatcatag agatcttttg caagggaagc acgcgggaaa tcaaaagaag 2276701 caaaatgaat cgcatgagca atggtttcca gtcttttaat catgttctga tacggtttgt 2276761 cctttaacgc gctaaacacc acagaaatgc gtgaattggc gaaacgctgc ttcatcgttt 2276821 ccgccagctt ttcaacacct tcttcgttat gcgcaccgtc taaatatacc ggaggatgtt 2276881 cctgaacaag ctctaaccgt cccggccaag cagccttcac aagcccgctc cttaacgctt 2276941 cgtcactgat atgggcgata ttctccttat tgagccactc cgcagccaaa atggacaaag 2277001 cagcattttg tctttgatgg gtgccaatca gagatgtccg aatatcttca tagcatttct 2277061 cttccgtttt gaatgaaaac tgttctcctg caggcagagc ctcttcattg aaaataacac 2277121 atgcatcatg caatgactgg aacggcgcag catgccgttc ggcttcatgg cggatgacct 2277181 gtaaagcttc cggctgggta actgctgtaa cgattggaat accttcttta ataatgccgg 2277241 ccttttctcc tgcaatttct tcaatggtgt ttcccaaaat gttcatatga tcgtgtccga 2277301 tgcttgtaat cacagttaag agcggttcaa ccacattagt agaatcgaat ctaccgccca 2277361 gacctgtttc aaaaataaca aaatcgacct tatgaaactc tgcaaaatat aaaaatgcac 2277421 aagctgtcat aatttcaaat tctgtcggct gtccgtattc cgtttgatca agggcttcaa 2277481 cgtgcggttt catttgattg acgagtgctg tccattcctc atctgaaatc ggtatcccgt 2277541 ttacgctgat ccgttcatta aacgtaataa tataaggcga tgtaaatgtt ccaaccgtat 2277601 atccggcttc ctgcagcata gaacggataa aagcgacagt tgatccttta ccgtttgttc 2277661 ctgcgacgtg gaacgctcgg attttttttt caggatgtcc taaccgcgcc atcagctgtt 2277721 tcattcgacc aagtccgggc ttcaccccga atttcagcct cccgtgaatc cagctgcgcg 2277781 catcttgata tgcagtaaac aatgataatc ccctctttta taagacaagg cggtttctct 2277841 agaaaccgcc ccggcttttc attaaccctt cagctcagcc attcgttttt gaacagcgtc 2277901 acgcttcgcc acataatctt tttctttttc acgttcttca tcaattacgt gtgcaggcgc 2277961 ttttttcata aatccttcat ttccaagttt cttttggaca cgctcaactt cttttgtcag 2278021 tttatcaaat tctttttgca gacgggcaat ttcttcatca atattgatta agccttcaag 2278081 cggaagaata acctctgctc ctgagacaac ggccgtcatc gccttatcaa cagcctcaat 2278141 atcggtgccg attttaagca cgctcggatt cgtaaagcgt tcaacatatg aacggttcgc 2278201 ttcgaggcgg gacgctattt cgtctgtgct tgttttaatg tacagttcaa cctgcttgct 2278261 cattggcgta ttgacttcac tgcggatatt gcgcacagaa cggatcagct caacaagaag 2278321 cttcatgtca gctgccgctt cagtatcggt atgctccggc actactgcag gccattgact 2278381 tactgtaatc gattcccctt ggtgaggaag gtgctgccaa atttcctccg ttaagaatgg 2278441 cataaacgga tggagcagac gcatcgtttg atcaagtacg taagcaagga tggaacgggt 2278501 agttttctta gccgcttcgt cttctccata aagcggaagc ttcgccattt caatatacca 2278561 atcacagaaa tcatcccaaa taaagttata taaatggcgt cctacttcac caaattcata 2278621 tcggtcagca agctgggtca cgtgctcgat cgtttcattt aatcgcgtta aaatccactt 2278681 gtcagcgact gacttttcac ctgacagatc aagctcatcg tacgtcatgc catccatatt 2278741 cattaatgca aaacgggagg cgttccaaat tttattggca aaattccagg tcgattccac 2278801 tttttcatag ctgaagcgca gatcctggcc aggagagctt ccagtcgcaa ggaaataacg 2278861 cagagaatcg gctccgtact tgtcaatcac atccatcggg tcgacaccgt tgccaagaga 2278921 tttactcatt ttccggcctt gctcgtcacg gattaagccg tggattaaaa catctttgaa 2278981 cgggcgctcg cctgtaaatt caatgccttg gaaaatcatg cgtgataccc agaagaaaat 2279041 gatatcgtac cctgtcacga gaacatctgt cggatagtag cgtttaaagt cttcagccgt 2279101 tacatcaggc cagcccattg tggagaaagg ccatagcgca gaactgaacc atgtatccag 2279161 tacgtctgta tcctgttccc aattttcgct gtcttccggc gcttcaagtc cgacatatag 2279221 ctcgcctgtt tctttatgat accaggcagg aatacgatgg ccccaccaca attgacggga 2279281 gatacaccag tcgcggatat tttccatcca gtgtaaatac gttttttcga aacggtcagg 2279341 cacaaagttg accttttctt cttttttttg cagctcaatc gctgcatcag caagcggctg 2279401 catgcgcaca aaccattgtg tagaaagata aggctccaca acagccccgc ttcgttcact 2279461 atggccgaca gagtgcatat gatcctcgat cttgaagaga actcccgcct cctgtaaatc 2279521 tttcacgagc tttttgcggc attcaaaacg atccatacct tgatattgga gcgcattttc 2279581 attcatcgtg ccatcttcat tcatgacaag gatgcgttct aaattgtggc ggttgccaag 2279641 ctcgaagtcg ttcggatcat gagcaggcgt aattttcacg gcacctgaac caaattccat 2279701 atcaacatag tcatcaccga caatcggaat ttcacgattt acaatcggca ggatcaccgt 2279761 ttttccgata aggtgtttat agcgctcgtc ttcagggtga acggcaacag ctgtatcacc 2279821 gagcattgtt tcaggacgtg tcgtcgcaat ttcaattgag cctgaaccgt cagcaagcgg 2279881 atagctcata tgatagaatg cgccttgaac atccttgtaa atcacctcaa tgtcggatag 2279941 ggctgttttt gtcgctgggt cccagttaat aatatattcg cctctgtaga tcaggccttt 2280001 ttcataaagc ttaacgaata cttcccttac cgctttgctc aagccttcat ccagcgtaaa 2280061 acgttcacgg gaataatcta ggccaagacc taatttcgcc cactggctgc gaataaagtc 2280121 agcatattct tccttccact tccacgtttc ttcgaggaat ttttcacggc ctaaatcgta 2280181 gcgggatttg ccttcttcac gaagtttcgc ctccacttta gcctgtgtcg cgatgccggc 2280241 gtggtccatg ccaggaagcc acagcacatc atagccctgc atgcgtttca ttcttgttac 2280301 aatgtcttgc agcgttgtgt cccatgcgtg gccaaggtga agtctccctg ttacgtttgg 2280361 cggcgggatg acaacagagt atggctcttt tgtctggtca ctgcccgctt caaaaaattt 2280421 gccttttagc caaaaatcat atcggtcttt ttcaaccgct gccggatcat atttcgtcgg 2280481 cattgtttgt tcattcgttt ccatcataac cctccagcat gtttaaaaat ggctgagaac 2280541 gaaaaaagag ctcttcatcc ctgtaaaagg acgaaaagct ctttcgcggt accacctttt 2280601 ttcatgaact caatcagttc atgcacttat aacggataac gggtgtttcc cgaatttctc 2280661 tactcttctt tcaagaaatt atgctcccgg gcgaccttcc aatcagacaa cataagaagc 2280721 ctttcagcaa acggcttctc tctctgcatg cgcctttttt gtactcttcc cgttctaagc 2280781 aggtgtattt atcagctcat tgtatacatt atttatgttc tttattatag taaaagtgtt 2280841 tttgattcgt caatcatctt ttccaaaaac accgctttct atacagatgg gcaggcacct 2280901 attgcccaag tttacatatg atgcttgtaa atgcgtagag gaggatgcac cgtgaagaaa 2280961 cgtttcagct cttattcgct gccgccatgg gtaaggcaaa ttcggcttgt atccgcacaa 2281021 gtgattattc ccattacgat ttttcaagga atcagaacca ttttctttcc gacaaccttt 2281081 gatgttttgc tgctcgcaat cctaatcttt ttagcttgcg cccttcattt agaatggata 2281141 taaacaaaca agtccgcgcc attaagacgt ggactcgttt tcagcctgaa attttttctc 2281201 ttgttcaatc tgatgaattt tcatcacaaa cggctctatg tttttcattt gccaataagc 2281261 ctttaataat tgtgtacatt cctctttttc atgctgtctt ttcccagttt gataaccgtt 2281321 cagcaccttg tacatggctg ccggatatgc catatagctg agaaaaaggc tgacttccgc 2281381 ttcacgcaaa gggaatgatt tcgtatatcc ataaaaccat tcgacgcatt ccggacaagc 2281441 tttcggaaag cctctgaaca tttttgtata aaagccgagc aggtcgtttt gcggcggacc 2281501 gacagatgct ctttcgaagt ttgtaaaata tccggtcccg gcatcattat acagaaaatg 2281561 gtgtatagac aggctgccgt ggttcattac aacccttgaa acgtcctttt cctttgcgga 2281621 ctcataccag tcctccagcc gttccagcgc aaagttcacc gcggaaatgg tttcagaaaa 2281681 ataggttatg gcctggagtt caaagggaga aaggtaccat tccttctccg ctctatccac 2281741 aaactgctca tagaaaattt tatcttgttc ccactttttt ttcgtttgcc cgtaataacg 2281801 ttcaatctca tcacgtctaa cctttagttc ctgcgcggtt ctctcgtgaa gacgggctgt 2281861 ttctctaaat aaataagcat gtttttgatc ccgttcttcc tcttggtcaa attggagcca 2281921 aggcattaaa tagtagatat ctccgtattg tatgcctgct gagaaaaact caccgctatt 2281981 tgttctgtaa acgggaacga atgaacgaaa gcctttttcc tcaatcgcca ccatatgatc 2282041 tgtaaaatgc ttgccgcgac cttctttcaa ttttttcagg gcaaatatgc cgtagtctgt 2282101 atacactttc caaacaagag gactgacagg ctcaataaat tgagcagtca gtccgtattc 2282161 ctgaagaacc gattgggtat cttccatttc attcaccaca ttttccgatc acttacggtt 2282221 tacgcatggc tatttttata ttgaggaata tagagaatct gtcctgcttt taattcatca 2282281 tccaaggcta aagaattcat cctgatcagc tgctgggatg taatttcata ccgttcgcat 2282341 aaacgctcga tcgtatcttc ctgctgcaca atacaaattt tcattctcga aaactcatcc 2282401 gcttcttttg taaagagttt tgttaaataa agagaattat cactttcctt tgtttgaggt 2282461 tccttcgttt cagcagcagg agcaacccta ggaacagcat ccgtttcctt cctttcagtc 2282521 tcagaagatt caggcagctg gaaggattga aaaggtgttt cttccttagg ctcttcagct 2282581 gatggtgttt ttctcacttc aatttcgaag ctctcttcct cttgttcttc ctcctccagc 2282641 agcttaggcg ctgaataaaa agaatcctcc tcttcttgtt caggcaggaa ggtacggtat 2282701 gccggttcag gcaattcttc ttgagatgcc tcctccgagc ttgttttttg attgaaatgg 2282761 aaatgtaaat cggcattgtc attctccata tatacagctg aagctgtttc tctgctatct 2282821 tctatggaga gagcggcctc tgatacactc tccaaagctt catccggttc cgcctcttct 2282881 tggcaaagcg caggatcagc ctgatccgat tgagctgctt cttcattttg agcctcttgg 2282941 cgcagcgcat attcatgatt aggagacact gttgtttcct ctttttcctt tgcaatcaca 2283001 gtctctgaat gaagctcagc ttccaaagca ggcgattctt ctgctccaac gtgttcacga 2283061 agctcagtct ccgctggaga gtctgcttct tcacgaacat ccgctattgc agctgccggc 2283121 tctgccgttt ctttttttgc tttaacgatc tcttgaatct ctatttctga aggatcaggt 2283181 tctggctcag attcttctgt ttccgattca gcacgaacct ccgtttccgg cacagcaagc 2283241 tcttctgact cttcttcctc tttcacatct tctctggcct ctggttctga agcaaccgat 2283301 tcaggcggct cagattctgc tttttctgtc tccagttctt cacggagccc cgctttcgag 2283361 ataaaaagtt ctggcggttc ggctggcggt tcatgctgaa gaactgcttc ctctgccgat 2283421 gatgcacccg gttcttctac tacactatgt gccggcggct ctgaaagctc ttcctccctg 2283481 aatgccgcag gagcttcata taaaggtatc tccggctctt tgtcttgcgt atcgtccaaa 2283541 agcccttcga tcgctaaatc agcttgaatt gttaaaatgc gcgaatccgt caattgatag 2283601 tcaaatgcgt caataaagac gaagacatcc tgtaaatggc tcactttatt tttcggaatg 2283661 gtaatatcca caggaaaaca gtgagtcagt tccgcacttc catcctctct ctttctgact 2283721 tgttcaacaa accgcttatc tgtataaatc tcttcggtat gtttgttttg atctatgttg 2283781 tactcacctg taagttcaag cgatcctatg attgatacat aatcatttac ttcctgaacc 2283841 ctaatatcag gatctaatga aatagaaagc agttcagaaa cttcctgtcc tttttggaaa 2283901 cagatcgatt cttctacaga aaattgcaat cgatgatttt gcggcaagtt catatcctcc 2283961 tttcatctaa tccttaaaat tagatgtcac taaaggtgta tgtatgaact ggagaaaata 2284021 tgagtgggag agcacgaaaa aaccggcaca aggagtcctt gataccggtt ttcactctta 2284081 tctgcggctg atctcagcaa atactttctc agctgcctgg attgtgtttt caatatcttc 2284141 atcagtatgg gccgttgaga ggaaaagacc ttcgaattgt gatggcggaa ggaatacccc 2284201 ttcatttgcc atccctttat aatagcttgc gaacagcttc aaatcagatg atttcgctgt 2284261 ttcataattg atgactggtt cgtttgtaaa gaagaaaccg atcatcgaac ctgcacggtt 2284321 aaaggtatgc ggaatgccat gagccccggc ggtttttgaa attccttctt ccagtctgtc 2284381 gccttttttg atgaaattct tgtaggattc aggtgtcagc tgtttcaatg tctctaagcc 2284441 agccgtcatc gcaagcgggt tgcctgacaa tgtaccagct tgatagatcg gaccgcttgg 2284501 agcgatctgc tccatgattt ctgcctttcc gccataagcg ccgacaggaa gtccgccccc 2284561 gattactttt cctaaacaag tcagatcagg cgttacgccg aagtagcctt gagcgcagtt 2284621 ataatcgacc cggaagccag tcatcacttc atcaaaaatc agcagggagc cgtactgctc 2284681 agtgatatca cgcagaccct gaaggaaacc ttcttgcggc ggaacaacac ccatatttcc 2284741 ggcaactggc tctacaatga ctcccgcaat gtcttcaccg aattgctgga aagcaagctt 2284801 tacactttct aaatcattgt acggaacggt gatggtgttt ttcgcaatgc cttcaggcac 2284861 ccccgggctg tcaggcagac cgagagtggc aacacctgaa ccagctttaa tcaagagaga 2284921 atcgccgtgt ccgtggtagc agccctcaaa ttttaaaatc ttgttgcggc ccgtatagcc 2284981 ccttgccaaa cggagggcac tcattgtagc ctctgttccg gagcttacca ttcgtacaat 2285041 ttctacagat ggcacacgat caatgacgag cttagccagt tcattttcta cttcagtcgg 2285101 agcaccaaag cttgtcccgt attcagccac ttttttgagg ctttctacga cgcggtcatt 2285161 tgtatgccct aaaattaaag gcccccatga caagacgtag tcaatatatt cattcccgtc 2285221 aatatcaaag attttcgagc cttttccgcg ctccataaaa atcgggtcca tgtctaccga 2285281 tttaaatgcg cgaacgggac tgttcacacc gcccggcatg agtttttgcg cttctttaaa 2285341 agccgttttt gatttttcat agcttctcat ctgcctcaac tcctgtcaac tgaataaaat 2285401 tactccgcaa gccatttcgc tgcgtctttc gcatgatacg taataatcag gtcggcaccc 2285461 gcgcgcttca tgcttgtcaa aatttccaac acaatttctt tttctttgat ccagccgttc 2285521 tgcgctgcag ccttcaccat tgaatactct ccgcttacat tataagcgac gagcggcaaa 2285581 gtaaactcat tttttacgtc acgcatgata tccatataag aaagcgaagg tttgacaatc 2285641 aaaaagtccg cgccttcctc aacatctgat tgtgcttcgc ggagtgcctc catacggttg 2285701 gcagggtcca tctgatatgt tttgcggtct ccgaattgcg gtgtgctgtt tgctgcatca 2285761 cggaacggac cgtaaaactc acttgaatat ttaacagcgt aagacatgat gggaatattg 2285821 acgaatcctt ctttatcaag tgcttctctg atcactgtaa caaatccgtc catcatgttt 2285881 gatggcgcaa tgatatccgc acctgctttc gcttggctga cagctgtctg cgccaaaagc 2285941 tccagcgatt catcattgag aatgactccg tctttgacaa gtccgcaatg gccgtggtct 2286001 gtatattcgc acaggcacgt gtcagcgaca acaaccattt cagggaagtg ttctttaatt 2286061 tctgtgatgg ctttttggac aattccgtga tcatggtacg cttgtgttcc gcaatcatct 2286121 ttttcttccg ggatgccgaa cacgataaca gattgaatgc ccagtttgac cagctccgct 2286181 acttcatcct tcaataaatc taatgataca tggtgaacat caggcattga cggaacagct 2286241 tttttgcctt ccagcccttc aacgacaaaa atcggatata taaaatctga tggatgcaaa 2286301 cgtgtttcct ttaccatttc tctcattgct tttgatgtcc gcaggcggcg gtgtctatta 2286361 aatgattgac tcatattctc tcttcctctc ttgacatgct gcacattaac tcaagcatgc 2286421 catctattgt aaatgtatca ggcgtatgcg atgtgatgcc gtacgtcaga agggcatcat 2286481 ttgttaaagg cccaatgctg atacaggccg tcccattcgc cttccacttt tttaattctt 2286541 ctcccaagac atgcataaac gtatgtacgg ttgatgaact cgtaaatgtt acatagtcaa 2286601 aggaatattg acccgcagcg tctttcaatg cctcaatgcc ttcttcatcc ggaatcgttt 2286661 cgtagagaac ccattccttt acttcaaaac cgagcgggac aagctcttgt tttatcacat 2286721 cacgtgacaa attccctttc atcacggtaa tggtctcccc cggttcagca tgctgcttaa 2286781 gagcgtcagc caattgttca gcaatatact cctgtggcat cacatcaacc gatacgttat 2286841 gcatttttaa acggcgcgcg gttttttcac cgacggctgc aattttttta tgcgcaggga 2286901 gaataagctg attttccttc agataagaaa aaaagaagtc tgccccgttc acacttgtaa 2286961 aaacaagcca gcctggcgcg gcaagatcct ctcttacctg ttccgcaaca tcattcggca 2287021 aagcgcggcg aaacgtaatc aaagaggtta aaaccgcttt accgccaagc gcctccactt 2287081 tttgctgaaa tgatgctgcc tgtgccttat tccgggtgac aagcactgtt tttcctttca 2287141 acggaaaatc attttccatc ctcgtcaagc tcccgtttta cacgatcaat taaatctttt 2287201 gctcctttgt cagccataag agcggcacag cgctttccta cttcctccgg atcgtttccg 2287261 gtgacggttt ctttaaaaat gattttgccg tcaggtgaag cgacaagacc tgtcatttca 2287321 atttcatcct gtccatttaa cacggagtag cccgcgatcg gaacctggca gccgccctcc 2287381 atcgcgttta aaaaagcacg ttccgctaag acagtccgtt ttgtatattc atctgtaaac 2287441 tgagaaaaca acgccaacag ctcttcatcc gattctcggc actcaatcgc cagggctccc 2287501 tgccccacag caggcaaaca gcgctcaggc tcaaggaatt cggttacgac atcttgcttc 2287561 caacccattc tggaaaggcc ggcagccgct aaaataattg cgtcataatc ctctgtttcc 2287621 agcttttgaa gtcttgtatc tatattacct ctaatccatt taattgtaag gtcagggcgc 2287681 tcaatcaaaa gctgcgcgct tcttcttaaa ctgcttgtgc caatgacagc acctttcttc 2287741 atttctgaaa gctttacgcg attctttgaa ataagggcat cacgcgggtc ctcccgttca 2287801 ggaatacagc cgatcacaag gccttcaggc aaaacagcag gcatgtcctt catgctgtgc 2287861 actgccatat caatctcttc gtttaaaagc gcctgttcaa tttctttgac aaaaagccct 2287921 tttccaccca cttttgagag tgtaacatcg acaatccggt cgccctttgt cacgatctct 2287981 ttaatttcaa aagcaaacga aggattgatt tccttcagtt tttgaataac ccattttgtt 2288041 tgagtcatag cgagtttgct ccgtctggaa cctactttaa tcgttctcat catttctttc 2288101 ctcccgaatc tgcttgggac atcgtttaac tgaaccaatg gaattgcgac aggcttccaa 2288161 gcaggaaata attgatcatc agcaccagaa aacaagccgt attccacagt gcagcgacct 2288221 ttccttgcag ctccttaatc agcctgatat aaagataata gctgtacagc agcaggacga 2288281 caaacgaacc aagcactttg gcgtcaaacc aatacagcgt ttctagtgag acatacgccc 2288341 aaatgacgcc gagaatcaaa ctcagcagca gcatcggaac cccaatgaca tttaaaacat 2288401 acgccatata atcaagctta gataaatctt ctattctcaa cagccatttt ccccactttt 2288461 tctttttcag cagatgatat tgaaacatat atagcacaga aaaaacgaaa gaaagggaaa 2288521 aagcgccgta tgaaagaatc gccattgtaa tatgaatcac caaaagctcg gatacaagct 2288581 gcccggaaaa agcagctgac tgctgctctg tcggtgaaaa tgtgtgaatg gcgatcatag 2288641 aaaatcctat aacatttgta aaaaacacga taaagtcaac acgtaaaagc tttgtcagta 2288701 caagtgacag cgtgacaagc acccaggcat aaaaataaag tgcctctgtc acatttaata 2288761 ccggaaaccg ccccgtcacc cacataaaat aggccaaata cacggtttgc agagtccaga 2288821 caatagaaag caaccagaag gccatttttc cagccttccg gttgtgttga agaaaatcta 2288881 taaaataaaa gagtacactt aacgcgtaaa tgacgattgt cccctcatta agtcttgcca 2288941 ttgcagtatc aatcattcag ctttcactca cttacaagtg ggctaaagcc cgcttttgat 2289001 tcagccttct taaaagagtg gaccttctgg ctgctttcaa cggttttcat catttgacgg 2289061 cccgcagctt cttcaatatc aaaaatctgc ataaacaacg cgagcttttc ttcagaatca 2289121 gcatctgccg caagctcttt cacctttaaa atcggatcac gaagcatttg gttaataata 2289181 cttttggtgt gtttgttcaa cagttttttc tctcttgtgc ttaagtgagg cagcttacgc 2289241 tcaatgctgt ccatcgtttc tgactggatg gcaagcgcct tttcgcgcaa tgcagaaata 2289301 acaggcacaa caccaagtgt attcatccat tgtttaaatt ccacaatggt ttcttcaatt 2289361 aacagttcaa ctttttcagc tgtttctctc cgctctttca tgttcgcttc tacaatgcct 2289421 tccagatcgt cgatatcata aagaaaaaca ccttcaagat cattcagcgc cggatcaaga 2289481 tctctaggca cggcaatgtc gaccataaac agcggacgtc ccttgcgaag cttattcgcg 2289541 ttttccatca tctctttgga cacgacaaat tcacttgcac cggttgaact gattaaaata 2289601 tcagcctccg caagcgcgct ttcaagctga ttcaagcttc tcgcttcacc tgaaaaacgg 2289661 tctgcaagct ccttcgcttt caagtatgtt cggttaatga cagtgacctt gccgattccc 2289721 tgtccgtgca ggttttccgc agcaagctcg cccatttttc ccgcaccgag aatcaatatg 2289781 tgcttgcttg aaagatttcc gaagattttt ttggcaagtt caactgcagc atagcttact 2289841 gacaccgcat ttgagccaat gtctgtttcg gcgtgagtcc gtttgcccac tgtaactgcc 2289901 tgcttaaaca gctcattaaa aatagtcccg atcgtttttt cttgctgagc tgttttaaag 2289961 ctgtcgcgta cctgtccgag aatctgcgtt tcgccaatca ccatagaatc aagtccgcag 2290021 gctacacgga ataaatgctc aacagcggca tcgctctcat aaaacgttaa gaacggtgac 2290081 agctcttctt tgcttaattg aaaccaatca gctaaaaact tttttatata ataacggccg 2290141 gtatgaagct ggtcgactac cgcataaatt tcagtgcggt tgcaggttga gacaatgatg 2290201 ttttcaagaa tgcttttctc ttctttcagc tgcaccattg cttctgccag ctcattcggc 2290261 tgaaaactta ctttttcacg tatctcaata ggggcggatt tataatctac tcccacaaca 2290321 agtatatgca tcgctctaat tacaccccca acacccaatc ttaatttata atcattctaa 2290381 catagaactc attatttata ataattataa catagtttct ttcacaaaat gtgaacagat 2290441 tttaaaattc ttatgctata ttagaaaaag cttcagggaa aagaagcatt cctattgaca 2290501 ataccaaaaa cagcagaaat ttactacaca tcagctctaa aaaacaagaa ggtgatatgc 2290561 atgaaacaaa aatcaatttt attcccttgt ctgctgcttg ccgcttctgt atatgcatgg 2290621 ctagaaagcg gccaagccga actgttttca gggcaggatc aatggcctgt tctcctcatg 2290681 ctgttaggcg cagcctttgt atatcaagga aaaaaagaag ccgtcacacc ccattttttt 2290741 atcggtttgc ttctcttcgg gatcggttta cacttttttg ccaagccgaa atgggtatgg 2290801 tggccggatg attttgaaat gctcctcttt atgatcggct tctcacttct cgtttcaacc 2290861 gttcaaaaaa aagaatatgt atatgaagct gtgtcgatga tttgtttttc cctgtttttg 2290921 tactttttca aacaaattat ggcatggctt gagtctgcgc atattccaac agcgcttctg 2290981 aaggagtatt ggccgtttgt ctttattgga atcagtttat tgttattatt gataaaacga 2291041 aaaaaatcta tacgataaat aaaaccggta gaggatcctc taccggttta tcattttttt 2291101 gatcgctccc caagcttcgt cttttccctt tttcgtttct gaagaaaaga ggatcagctc 2291161 gtcttccgga tcaatattta atgtttgtcg gacaaccttc gcgtgtttgt cccatttacc 2291221 tttcgggatc ttatccgcct ttgtagcgat aacaataaca ggaatgccgt aatactttaa 2291281 aaattcatac atctgtacat catcattaga tggcgcatgc cgcaaatcaa cgatctgcac 2291341 cacagctttt aattcctcgc gtgtcgtgat ataggtttca atcattctgc cccatgcttc 2291401 acgctcagac tttgacactt tggcaaaacc gtagcccggc acatccacaa aatgcagctc 2291461 atcattgata atgtagaaat taagcgtttg tgtttttccc ggctttgatg acgttctcgc 2291521 aagatttttg cgattgatta atgaattgat aaaagacgat tttcctacgt tcgatcttcc 2291581 ggccaatgcg atttccggaa gccccccttc agggtactgt tccggtttta ctgcactgat 2291641 cacgatttct gactttgtga ctttcatttc ttctctccta ctaaggcatg ttccaaaacc 2291701 tcgtctaagt gggacgccaa tataaatgtc agcccctccc tgacgctttc cggaatatcc 2291761 tctatatctt tttcattatc tttaggcgca ataatggtcg ttaatcccgc tctatgtgcg 2291821 ccaagcgctt tttcctttaa gccgccgatc ggcagcacgc gcccgcgaag cgtgatttcc 2291881 ccagtcatgc cgacttcacg cgaaaccgcc cgtcccgtta aagcagaaac aagcgctgtt 2291941 gccatcgtaa taccggctga cggaccatct tttggcaccg caccctctgg tacatgtata 2292001 tgaatatcat acttctcatg aaagtcaggt tcaatgccaa gttcttctgt tttggatcgc 2292061 acatagctga atgcagcctg agcagactct ctcataacat ctccgagctt tcctgtcagg 2292121 attaatttcc cttttcccgg tgaaagcgat acttcaatcg aaagcgtatc tccgccaacg 2292181 gttgtatacg caagccctgt cactacacca acttgatcct ctgtttcagc ttgtccatat 2292241 ctgaaaatgc gttttccgat aaaatcttga aggttcttct cagtaaccgt aattcgtttt 2292301 cgctcttcag caacaatggc ttttgcagct ttacggcaaa ttgcggcaag ctggcgttca 2292361 aggcttctta cacccgcttc tctcgtatag taacgaataa tatcaagaat cgcctgatca 2292421 cgcagctgaa gattgctttt cttcagcccg tgttctttga tttgctttgg aagcaagtga 2292481 tcctttacaa tttcaagttt ttctatttct gtgtagcctg cgatattaat aatttccatt 2292541 ctgtctctga gcgggcccgg gattgtggcc aaattgttcg ccgttgcgat aaacagcact 2292601 ttggataaat caaaggtttc ttcaatatag tgatcactga agctgctgtt ttgctctgga 2292661 tcaagcactt caagcatagc ggatgatggg tctcctctaa aatcagatga cattttgtca 2292721 atttcgtcta ataagaagac cggattcagc ttgcccgctt ttttcatccc ttgaataata 2292781 cgtccaggca ttgctccgac ataggtccgt ctgtgtccgc gtatctctga ttcatcccga 2292841 actcctccga gtgagattct gacgaatttg cgtcccaagc tttttgcaat tgatttggct 2292901 aaagacgttt ttccgacacc tggaggtcct gccaaacaga gaatcgggcc tttcagggat 2292961 tttgtcagct tctggacagc caaatattct aaaatacgtt cttttacttt ttcaagcccg 2293021 tggtgctctt cgtccaagag acgtcctgct tctttcaaat caagcttatc atctgtttca 2293081 tccgtccacg gaagagcaac cagccagtcg atatagttgc ggatcacaga gctttccgca 2293141 gaacttgacg gaattttttc atatctgttc aattctttaa gcgctgtttc tttcacatga 2293201 tcaggcatgc ctgcttcttc gattttttcc gtcagcgtct gaacttcgcc agttttgcct 2293261 tctttatcgc caagctcttt ttggatcgcc ttcatttgtt cacgcaagta gtattccttc 2293321 tgcgtacgct ccatcgaacg tttgacgcgc tggccgattt ttttctcaat ctccagcact 2293381 tctttttcat tattaataaa atcaatgacc ttgttcagcc tgtctttgac atcagccgtt 2293441 tctaaaatat cctgcttatc ctttagttta aggggcagat gagaagcaac gatgtctgcc 2293501 attctccccg gctcttcgat atcagtaacc gcagcgtacg tttcggccga gattttttta 2293561 gaaattttta tgtactgatc aaagtggtct agcaaagtcc gcatcaatgc ttcgtcttct 2293621 gtatcttttg aatcatcttc atgaataagt tgaatgtcaa ccgacgtgta atcctcgtgt 2293681 tcattgtatt tgacgatatg ggcgcgcttg aggccctcca ccaacacacg aatcgtaccg 2293741 ttcggaagct tcagcatttg cttaattttt gtataggtgc cgacagtgaa aatctcgtct 2293801 tcaccaggtt cgtctatcga aatatcctgc tgagtggcta aaaatatcat atgatcatgc 2293861 atcattgcct gttcaagagc ctgaaccgac ttgtcacgtc ctacatctaa atgcaaaacc 2293921 atcgtcgggt acactaataa acctcttaaa gggaggagcg ggatgctgcg ttttaattct 2293981 tctgccatgt gactgacacc tccgtgactt tagtatgaac cattataata caactttttc 2294041 atccttgtac aataaacggc atggttccat tttctataaa acagtctcct cgtagtatac 2294101 cctttctttc tgatatgaaa aaggaaaaga tgtccttcat gaaaaaaacc ctattatcaa 2294161 aatagggttt aaacggattc tttattgatt tcgatatgaa acggtttttg ttccgttggc 2294221 ggattcacca aaatttcatc aagcacttct tggaacgtct tcactgcaat aatctcgatc 2294281 ccgtcaatct gctttaagat ggcctgctga ttttcatatg ggataatcac ctttttcgca 2294341 ccggactgct tggccgcttt tattttcgga atgacgcctc cgatgggttt cacaagaccg 2294401 ttcaggctga tttcgcccgt catcgcaacg gtattgtcaa taggaatttt gtgtatcgcc 2294461 gagaaaatcc ccgccgccat cgcaatgcct gctgacggcc catcaatcgg aatccctcct 2294521 gggaaattga tgtgaatatc ataatcagaa ggcttcattc ccattgtccg gagcacggtt 2294581 aatacatttt caaccgaacc cttcgccatg ctttttcgcc tgatcgattt tgattggctg 2294641 ccgatgcttt cttcttcagc tattcctgtg atgttaattg atcctttatc ttgagccgcg 2294701 gttacactta cttcgatttc cagaagcgat ccgctgttag gcccatagac tgcaagccca 2294761 tttacaatgc caacctgtgg ttcaacaccg attttttgct cgtgctttgg agtaagctga 2294821 ctggagtgaa tgacccattc aatatcctca atcgtaatgt cctttcgatt ctccgttaca 2294881 gccatccccg ctgcgatttg aatcatattg acggcttccc gcccgttccg cgtgtagctg 2294941 gtcaaaagat ccagtccttc ttcggagata tttttttcaa ttttatccgc tgctgttttg 2295001 gcaaccgttt tcagctcgtc cttttcaagc tcgcggaaaa aaacctccaa acagcgggac 2295061 cggatagctg gcggaatttc gtttggcatt ctcgtggtcg cgccaatcaa gcgaaaatca 2295121 gccggcagcc cattttgaaa aatatcatga atatgattcg gaatttgtgt attttcctca 2295181 ctgtaatacg cactgtctaa aaagactttt ctgtcctcaa gcaccttcag cattttattc 2295241 atttgaatag gatgcagctc ccctatttca tcaataaaca gcacaccgcc atgggcatgg 2295301 gtgacagctc cctgcttcgg ctgcggaatc ccagcctgtc ccatcgctcc ggccccttgg 2295361 tatatcgggt catggacaga gccgatgagc ggatcggcaa ttcctctttc atcaaaacgg 2295421 gctgttgtcg catcgagttc cacaaagaca gcctgctctt taaacggtga ttgtttatgt 2295481 ttttttgctt cttccaacac aagccgcgca gcagccgttt tcccaactcc cggtggccca 2295541 tagacaatca catgctgagg atttggcccg cataaagccg cctttaatgc tttaatgccg 2295601 tcttcctgtc cgacgatatc tttaaagctt ttggggcgga ccttctcaga taatggctcg 2295661 gacaagctga tagcgcgcat tttccgaagc tgctccattt ccttctttga ttctttatct 2295721 atcgtgacct tttgtgtcct ttgattttta agcaaattcc aaaaatacaa accgatgatg 2295781 atcccaaaaa acagctgaat aaataacgcg atccctgtcc aactcatggt ggtccctcct 2295841 gaaaaacaat ttatgtatcc aattcattcc tctgattgct agtatctccc atagaagacg 2295901 ggaataaacg tttttccgga agagttgcat gcaaaaaaac ctcctgagtg ttaccactca 2295961 ggaggtttgt gcttatcttt atgcagatgt tttatcttgg cttacctcag tgccgtcttt 2296021 taataagagg cgaggaggct ctccgtgtgt cacagttgcc ccggtgatta cacatttttc 2296081 aatgtcatca cgagaaggca gctcaaacat cacatcaagc atgatgcctt caatgataga 2296141 acggagtccg cgtgctccag tcttgcgttc aattgctttt ttagcaattt cagaaagcgc 2296201 ttcttcttca aactcaagct caacgttgtc aagctcaagc attttcttga attgcttaac 2296261 aagagcgttt ttcggttttg ttaagatcgc aaccaatgct tcttcgtcaa gcttttcaag 2296321 gcttgcaata accggaagac gtccgataaa ttcaggaatt aacccgaaac ggagcaaatc 2296381 ttctggaagc acttttgaaa gaagatcttc tttctcaaga tcagcagctt tattgtcggc 2296441 accgaatcca atcacttttt ggcctaaacg gcgtttgatg atttgttcga taccatcgaa 2296501 agctccgccg caaatgaaca aaatatttgt tgtgtcaatt tgaatgaatt cttgatgagg 2296561 atgcttacgt ccaccttgag gcggtacgct tgccactgta ccctcaagaa ttttaagcaa 2296621 tgcctgctgt acaccctcac ctgacacatc acgtgtgata gacgggtttt cagattttct 2296681 agccacttta tcgatttcat caatatagat aatgcctttt tcggcttttt ccacatcata 2296741 atcagcagct tggatgagct tcaagagaat attctctaca tcttcaccca cgtatccagc 2296801 ttcagtcaaa gatgtagcgt ccgcaatcgc aaacggcaca tttaaaatgc gagccaatgt 2296861 ttgcgccaga agggttttac cgcttcccgt agggccgatt aatgaaatat tactttttga 2296921 aagctcaaca tcatcaactt tgctgttgga gttaatgcgc ttatagtggt tatacacagc 2296981 aacagcaagt gatttcttcg cttgatcttg gccgatgaca tattcattca aaatttcgcg 2297041 aatttcctga ggctttggta cgtctttaaa ttctacttct tcttctgttc cgagttcttc 2297101 ctctacaatt tcagtgcaga gttcgataca ttcgtcacat atatatacac caggtccagc 2297161 tacaagctta cgaacctgat cttgtgtttt tccacagaac gagcatttta attgtccttt 2297221 ttcctcgtta aatttaaaca ttctttcacc ccttaatctt gtctcacttt ttcttttacc 2297281 ggcagagcaa aagaaaatga ttcttgaaac gaacgagtat gtattgcatt ttaccatact 2297341 ttccaaaaag acggtaacaa tgtgtttctg acttgcacat tctatatgta tgacaaaaaa 2297401 cagccctgca ttaactatat tgccccaaga aaaagagata actcataatt gtacaaaaca 2297461 aggcacgaat gattcgcgcc ctgttttatt agtactatta ttatgcacca tattaacggt 2297521 tttctacaag aaaatcaatt gctttgcgaa cttttaaatc ttctttcatc gcgtcagtag 2297581 aaccgatggc ttgtttaata ttttcaacag gcatgttgta tgcttcagcc atttttgtaa 2297641 gctcagcatc aacttcctca tctgatactt caaggttttc cgctttcgca atcgcctcaa 2297701 gagtcaggtt agattttacg cgtttttcag catcttcttt catttgctct ttaagcgcag 2297761 cttcatcttg gcctgagaat tgagtgtaaa gctcaaggtt catgccttgc atttgcagac 2297821 gctgttcgaa ttctttcagc atgcggtcaa gctcagtgtc gaccattgct tgaggcacat 2297881 cgatttcagc attttcagaa gctttcagaa caagctcttc acgcaattta gcgtcagctt 2297941 cgttttcttt tgcttcttct aaacgtttct ttgttttttc agttaattca gcaagtgttt 2298001 ccacttcttc atcgatatct tttgcgaatt catcgtcaag ctcaggaagc tctttcgctt 2298061 tgatttcgtg aattttcact ttaaacacag ctggtttgcc tgcaagatct tcagcgtggt 2298121 actcctcagg gaatgtcact tcaacatcct tctcagcacc tgcttcaagg ccaactaatt 2298181 gatcttcgaa gccagggatg aatgaaccag aacctacttc tagagagtag ttttcagctt 2298241 ttccgccttc gaaagcttcg ccgtcaacga atccttcgaa atcaagaaca actgtgtttc 2298301 cttcttcaac ggcgccttct tcttttacaa caagctcagc ttgacgctct tgaagggctt 2298361 ttagttcgtt ttgaacatct tcgtcagtta cagttgtgtc gtctttttca atgcccaggc 2298421 ctttgtattc gccaagcttc acttcaggtt ttactgttac tttcgcagtg aagattaagc 2298481 tttcgccttt ttcgattttt tcaacatcga tttcaggacg gtctacaggc tcgattccag 2298541 cttcttcaac cgctttaggg tattctacag gaagaagaat atccaaagca tcttggtaaa 2298601 gagcttctac gccaaagcgc tgttcgaata atccgcgagg aattttacct ttacggaatc 2298661 caggaattga aacttgtttt actacttttt taaatgcatc atcaagtgct gttttaaacg 2298721 tttcagcatc aacttcaacc gttaaaacgc cttcgttgcc ttcttgtttt tcccatttta 2298781 cagacatgtg tttccctcca aaaatctatt caggttgtgt cggtcttcca ttctaaagca 2298841 atcattcggc ttcgtccaac aaaaacaaag ctgccaaaga tcagaatcat tatgtataga 2298901 tgttaataat gaactgcaaa gcctgtccaa ccgtatttct tataacccgt tatacacaaa 2298961 tacaaccact atattataac ataacacata gcgctttcaa ctatatggcg cgatttacaa 2299021 ataagaaatt tcttcaatat cttttaacat tgtgcaagct tcatcgagtt ctctgtctgt 2299081 aaattcatac atcatatgaa gttcttcgct ttcaatttca atcccgtgca tctcgtaacc 2299141 gactttatga agggcagccg cccaaaggtc agccgacagc aatttcggct ggaacggata 2299201 taaaacgtac aaatgtcttc tccacaattc ttctactgct gcatataagg ttggattttc 2299261 atttccaagt gtctcatcta gcaccctgag aacacggtga agaatcggcg cggcatcagg 2299321 cggaacaatc tctgacggtt caattgtcaa cgactcgcca aatttactaa tgtgtacagg 2299381 tttactgtac tcatgctcag ccaacagcat gacaatcatc gttttgataa tcggatgggc 2299441 tgaggggtct tggaggattg ttttgagcaa tcctgtatac tttgctacgt tacggtcttt 2299501 taaggaatga atgagattca tttgctcctc agggcttgcc agcactttct cggtgtcaat 2299561 tgtatcctca tattcttcgg cccaagcctc gtcctcacga tccggatcgg tcattttccg 2299621 gctgaaatcc agcagcttat aaaattgctc ggcactttct gccggcagct gattttcttc 2299681 caaaacggct tcaatggtgc ttttgacttc ttcgtacttt ttgagctgaa ttaagatggt 2299741 catgtacacc tgcaaaaccg taaaataatg gccataacct tctttgagca tcttctcgca 2299801 cacgctttct gcctcttcca gctcgcccag ctctaaaaag cagatggcca tccctaagtg 2299861 aagatcggat tcagtatcat catatttcat cgcttctgaa aacagttcaa gcgcttcttg 2299921 atactttttt tccttgagtg atgacatccc tttttccaca aggcggtctt tcagatgagg 2299981 aaaaggaata atttttgcgt ttttcttgtc atgcgtcata cctatattcc tttcaggcat 2300041 ttattttgtt caagtgtatc aacacctgtg aacaaaaaca agaaatgaaa ggtttcacca 2300101 ggcaaaaaaa gccgccggac aaataccggc cgctttttca ggcttgaagc caagagcttc 2300161 tttgtgattc aaattgcttg atttcatctt ccagcagcag cgttaatgaa atttcatcat 2300221 atccgttgat cagcatctct ttccaatgcg gatcaacttc aaatgaaatt tgattgcctt 2300281 cactgtcatg aatcagctga ttttcaaggt caacagtcat ttgcaatgac tggttttcat 2300341 actggccgac aagctgtttc caattgtcat atggcatgcg gatcggaagc atgccgtttt 2300401 taaagcagtt ctgatggaaa atatcagcga atgacggcgc aatgataatt ttaaacccat 2300461 aatcatcaag tgcccacgga gcgtgttcac gcgatgaccc gcagccgaag ttttctcctg 2300521 ctattaaaat ggaagctcct tgataaacag gctggtttaa ttcaaattca gggttcggtt 2300581 caccattcgc atcatatctc cagtcaaaga atgcaaaacg tccgtagcct gttctttcaa 2300641 tcctcttcaa aaattgctta ggaataatct ggtctgtatc cacattgatc cgatttaata 2300701 cggctgcttt ccccgtatgt gatttcaaag gttccatctc gcgcactcct tacacaactg 2300761 ttttttcctg ataaaacttt ctgacatcaa cgaagtgtcc gtgaatggca gccatcgcag 2300821 ccattgccgg gctgacgaga tgtgttcttg caccttttcc ttgtctgccc tcgaagttgc 2300881 ggttagaggt tgatgcacag cgctctccct caggaacaac atcattattc atactcaaac 2300941 acatgctgca gcctgactct ctccattcaa atccagcttc caagaaaatc tggtcaagcc 2301001 cttctttttc agcctgaagc ttcacgcttt gggatccggg cacgacgatg gcccttacgc 2301061 tgtcagctac cttcttccct ttgatcatgt cagcagcctg tcgaaggtca gtcatgcggg 2301121 aatttgtgca ggaaccgata aatacgtgct ccactttaat gtcttcaatt ttttggtgag 2301181 gagtcaatcc catatattca taagcacgaa tcgcttcttt tttatcgtct tctgcagaaa 2301241 agctttccgg cgcaggaact tcagaatcga caggaagaac cattcccggg ttaatgcccc 2301301 atgtcaccat aggggaaatt ttgttgccgt caaggacgat agatttatcg taaacagcgc 2301361 ccgggtctgt gcgcagcgcc ttccattcct ctacggcctt gtcaaattct tcgccttttg 2301421 gcgtgtactt gcgatttttg caatattcaa acgtcacctc gtcaggtgca atcaaacctg 2301481 ctcttgctcc tgcttcaatt gacatgttac aaacagtcat tcgttcatcc atcgtcatat 2301541 ttctgaatac ttccccagtg tattcaatga cgtagcctgt gccgaatttc acaccgtatt 2301601 tgccgatgac agcaaggatg acatcctttg ccgttacccc tttttgaagc gttccatcta 2301661 cgcgcacttc aagtgttttt ggacgctgct gccaaagtgt ctgtgtggaa aggacatgtt 2301721 caacttcact cgtcccgatt ccaaatgcaa gagcgccgaa agcgccatgt gttgatgtat 2301781 gactgtcacc gcacacaatc gttttccctg gaagcgttaa gcctagttca ggtccgacga 2301841 catggacaat cccttgatcc acactgtgaa gatcggcaag gcgcacgcca aattcctcac 2301901 agtttctttc aagcgccgtt acctggcgtt tcgcaacttc atcctttatc tcaaaacgat 2301961 tgacagtcgg gatgttgtgg tccattgtcg caaatgtgtt ttggggtctt ctgacctttc 2302021 ttcccttttg tctcaagcct tcaaatgcct gaggagacgt cacctcatga atgaggtgca 2302081 aatcaatata gagaagatcc ggctttccct caccatgttt tacaatatgc tgatcccaaa 2302141 tcttttcgat gattgttcga ggcatcatct tttatttcct ccctctacct agagctaaga 2302201 ccgcttaacg taagctgtca cacattagaa attgtatttt cactcatgat tgctgcctta 2302261 acttcctctg taatggcctg agtgctgctg aactcttcac tccgtgccaa gtctcttgtt 2302321 ctttttccag aagccaagac tttgtttacc gcatcttcta cagctttcgc ttcctcttca 2302381 agcccgaaag atgttctcaa aagcattgcc gctgacaata tggctgcgaa cggatttgcc 2302441 atccctttac cggcaatatc aggcgcggag ccatgaacag gttcaaacag atgaaggcca 2302501 gagcttgata ggctggctga cgggagcatt ccgagcgagc ctgtaagcat ggacgcttca 2302561 tcgcttaaaa tatcaccgaa catattttca gtcaccacga catcaaattg attcggtgca 2302621 taaattagct gcatggccgc gttatccaca agcatgtgct caagcttcac atcaggaaat 2302681 tcttgtgcaa cgtcctcagc cacttcacgc cacagccggc ttgattcaag aacattcgct 2302741 ttatctacag aggtcacttt gccttttctg gctgccgcca ttttgaagcc ctctctgatc 2302801 actcgttcaa tttccgttcg cttataaaac agtgtatcta ctgcttcctg ctcaccttca 2302861 gtgtttacat aacgtttgct cggctggccg aaatacaagc cgcctgtgag ctcacgaacg 2302921 ataacgaaat caacattatc tatatattct tttttcaaag gcgaagcgtc agaaaggctt 2302981 tcaaatacct tcacaggccg caaattcgca aacaaatcaa gctgttttct gatgctgagc 2303041 agcccttttt ccggtctcag ttccgaagga ttttgatccc atttcggtcc gccgacagca 2303101 ccaagcaata tcgcgtctgc atttttacaa gcagcaacgg tttcctccgg gagggggtta 2303161 tgatgttcat caatagccgc ccctccaatc aggccatatt caaattcaaa ttcatggtta 2303221 aagcgttcgg caacactttt cagtacgtct gtcgctgatt ctaatacttc agggccgatc 2303281 ccgtctccgg gcaatagagc aatacgtttc ttcaagttaa ccgttctcct ttcttttatg 2303341 atccgacagc tgtgtggttt ttcaatccgc tcatattcga ctggaaaacc aattgacggt 2303401 ttactgcgtt caaataggct ttcgctgatg cttctaatac gtcttgcgct atgccccgcc 2303461 ctgctgattc ttttccgttc accaaaactc ttacatacac ctgggcaaat gcatcttcgc 2303521 cttttctatt agactgaatg cggtagtcta agagctccac atccttatcg atgcagcgct 2303581 caagcgtatt gtagattgct tccacgcttc cagctccagt tgcagcttcc tgaataagct 2303641 gtgcgttttc ttgatttttc aaagatagag tagccgtagg gacctgactt gttccgtaat 2303701 gtacttgcag agaaagaaat tcatacccaa tcttgcgatc tgttactttt tcttctaaaa 2303761 taagagaaac aagatcctca tcagtgattt cttttttctt ctcagtcaac tctttgaaca 2303821 tcgtaaagaa tttattaatc tcttcactgt caaattggaa tcctaaagca gtcagccggt 2303881 ctttaaatgc gtggcgtccg gaatgtttac ctaggacaag cgcatctgcg gttacgccga 2303941 caagctccgg tgaaataatt tcataagtcg atttttcctt taaaaagccg tcctgatgga 2304001 tgcctgattc atgagcaaat gcattatctc caacaaccgc tttgttgcgc gggacagcca 2304061 tgcctgtcag tttgcttact aaatcacttg ttctcttaat ctcgttcagc gtaatacctg 2304121 tttcgacttg gtagaaatct tttctggtat ggagggctac ggcaatttcc tctaatgccg 2304181 cgtttccggc tctttcaccg atcccgttca cagcgcattc gatttgatca gcgccatttt 2304241 caatcgcagc aagagagttt gcgactgcca ttcccaaatc atcatgacag tgggctgaaa 2304301 gctttgcttt gtgaatgttc ggaacgtttt ctttcatata tttaaagata tttccgtatt 2304361 ccgccggggc caggtagccg acagtgtccg gaagattgat aacactggcg cctgcgtcaa 2304421 tcactttctc gacgatttct gctagaaacg gcagttcagt gcggcaggca tcttcagctg 2304481 accattgcac aatcggaaaa cgttcttttg cgtatttcac cattccaact gctctttcaa 2304541 tgacttgttc acgtgtcatt ttcagcttgt gcttcaaatg aatgtccgat gtcgcgataa 2304601 atacatgaat tcttggttga gcgccatcct ttaacgcttc ccaagcagca tcaatatcac 2304661 cttttacaca acgggccaga ccagttactg aacaattttt aatggttctt gcgatttcct 2304721 gaacagctaa aaagtcacct cgggacgaag cgggaaatcc cgcttcaatg atgtctgccc 2304781 cgagtctttc gagctgctta gctatggcaa gtttctcctg tgtattcaag ttcactccag 2304841 gggactgttc accatcacga agcgtcgtat cgaaaaaatt aattttgcgc aacggagacc 2304901 accgcttcct tcttcttgcc ttgtttcaca aacggcatca tttcacgaag ctttcttccc 2304961 actacttcga tttgatgttc gttctcgctt gcattgatag cgttgaaacg aggacggttt 2305021 acttggtttt cgacgatcca ctcttttgcg aatgtaccgt tttggatatc ttttaatact 2305081 tctttcatag attcttttac tttggcgtcc acaacgcgag ggcctgatac gaaatctccc 2305141 cactgtgctg tgtcagagat tgaatatctc attcctgcaa gtccttcttc gtacataagg 2305201 tctacgatta atttcagctc atgaagacac tcgaagtatg caagttcagg ctgataacct 2305261 gcttcagtta aggtttcaaa tccggctttg acaagcgcgc ttaatccgcc gcaaagaact 2305321 gcttgctcac cgaacaaatc tgtttctgtt tcttctttaa atgtcgtttc taatacgccc 2305381 gctcttgcgc cgccgattcc tttagcataa gcgagggctt tgtctcttgc ttctccagtc 2305441 acatcttgat agattgcgaa caatgcaggt acgccagctc cttgctcata tgttcttctt 2305501 accaagtgtc ccgggccttt aggggccact aagaatacat ctacatccgc cggaggaaca 2305561 atttgatgga aatgcacgtt aaatccatga gcgaatacta atgattttcc tgctgtcaat 2305621 tcatctttga tttcagcttc gtatactttt tgctgctgct catccggaag cagaaccatg 2305681 atgatttcgg cttgggctgc cgcttctttt actgaaaata ctttatgtcc gtcttcttgg 2305741 gcttgagtga aagattttcc ttgtctaaca ccgacgatca cgtctactcc gctttcttta 2305801 aggttcaggg catgtgcgtg gccttgcgaa ccgtacccga taaccgctac tgtttttcca 2305861 gccaatacgt tctctttgat atcaccgtta taatatactt ttaccatttc aatctctccc 2305921 ttgttatgtt ttatacaata gatattgttt tattggatga cgccttttgc tgggttcccc 2305981 tcgcaaaagc cgttgtacct gttctcgcga tttctttaat gccataaggt tttaataact 2306041 caataagcgc ttcaattttg ttagattcac ctgtcacctg aacaacgatg ctgtctctgc 2306101 tgacatcaac gacagaggct ctaaacggtt ctatgattcc attaatctct gttcttgttg 2306161 aaggtgcgga gacaaccttg attaaggcca gctccctctg gacaatcgat tgatttgtga 2306221 tgtctgtgac tttcagcaca tcaatctgtt tgttgagctg tttcgttaac tgttcaacat 2306281 cattttcacc ttcaacatga acgacgaagg tgattctgga aacgccggct gtttctgtgt 2306341 gtccaactgt aatgctttca atgttgtaat gcctttttgt gaatagaccg gtgatccggt 2306401 ttaacacccc ggagcggttc accacagtca atgtgataat tcttttcaag gtttcacccc 2306461 caccatttca tgcagccctt tccccggagc caccatcggg aatacttttt cttcgctggc 2306521 aacccgcacg tcaatgacaa caggttctct tgatgttaat gcctcttcca gcttttcctt 2306581 tgcttccgct tctgatgaaa ttctgatgcc tttaatgccg tatgcttcgg acaatttgac 2306641 gaagtcaggc tgagaagcga atttagattc tgaataacgt tcttcataga aaatttcctg 2306701 ccactgtctg accattccga gacaagcgtt atttaaaatc actaccttga ccggaagatt 2306761 taattcgcga ataacatcga gttcttgaag cgtcatttgg aatccgccgt ctccgacaac 2306821 cgcgacaaca gtagcatctt tttcggccag ctgtgcgccg atcgccgccg gaagaccgaa 2306881 tcccatcgtt ccaagtccgc ctgacgtgac ccatttatct gctttttgga acggataaaa 2306941 ttgcgctgac cacatttgat gctggcctac atccgttgcg acaatggcct ctccttttgt 2307001 aaattgatga atatattcaa tcaatttctg aggtttaaaa ccttcttctt cattatctac 2307061 ataccagagc ggatactctt ctttccattc tgcgagctgt tttttccatt cgcttgaatc 2307121 gctttgtttg ccgtcttgtt tgatcagctc ctgcaggaca attttgctgt ctccgactac 2307181 aggaatctgt gttttcatga tttttccgat ttcagctgga tcaatatcga tgtgggctat 2307241 ctttgcgttt ctggcaaagt gtttcaggtt tcctgtgaca cggtcatcaa aacgggcgcc 2307301 gatactgatt aatagatcac attcatgaag ggccatattg gctgtataag taccgtgcat 2307361 tcccgccatc cctaggaaaa gcggatggtc agccgggaag cctccgagcc ccaaaagggt 2307421 gtgtgccaca gggatttgct gctgttcagc ataatttttt aattcttctg acgcttttcc 2307481 gtgcagtacg cccgcacccg ccaggatcac cggttttttc gcactgctca cggcttccac 2307541 aagcttgcgg atctgcaaat aattcggctc tgttgtcggc tggtatcccg ggagattcat 2307601 ctcatgatcg tagctgaatt ctccttcaat tgttgctaca tctttcggaa tatcaatcaa 2307661 tacaggtccg ggtcttccag ttgttgcaat atggaacgct tctttaatga tgcgcggcag 2307721 atcttccggc tggcgaacct ggtagctgtg ttttgttact ggcatcgtaa tccctaaaat 2307781 gtctgcttcc tgaaatgcat cgctcccgat tacagaggtt gctacctgcc ctgtaaagac 2307841 gactaacggc aatgaatcaa tcatggcatc agcaaggcct gtaacaaggt ttgtcgctcc 2307901 cggccctgac gtggcaatga cgacacccgg ttttccggag acccttgcgt atccctccgc 2307961 tgcatgaatt gctccttgtt cgtgacgggg aaggatatgt accaaccctg aattgtatag 2308021 cttatcgtaa atcggaagca cagccccgcc cggataaccg aagatcattt ctactttctc 2308081 tttttttaat gattcaatca gcattaatgc tccgctcatc gtctgtgtac attcggcaga 2308141 tgctgaatcc acctgtacat tagtccccat tttagttcct ccttttggat tttcatcctt 2308201 taaagatcat cttttcatta gctagatagc tgattattca ataaaaaaag cccttccgcc 2308261 cacaatcagc cgcgcagtaa ctgcgatagc taaaaggggc gaaaaggctt ttctttccgc 2308321 ggtaccaccc ttgtttacgg cctgttaatc ggccgtctca tggatatttc tatccgcttt 2308381 agtaacgagt gaatcaagtt cacccggcca agtcctactg tcatttcaga ctggcactct 2308441 gaggcgagtt caccttgtaa agcttcgccg gttctcagct aacccggttc tctgtggaaa 2308501 actttatcaa ggctacttat cctcatctgc gcttttcata ttcagccttc ggaacggctt 2308561 tccagctgtt caagaaggtc gtttgttttt cattttttta gaatcatact gcgatgattt 2308621 tcgcttgtga agcttgcatt tatcttttgt tgaactcata ttacgccgct ttggacgcag 2308681 tgtcaacagc attttttaaa attattagac aattttgatt aatcaatcta tattgtatac 2308741 gctttcatta ttggtacaaa aggaattgca aatgttaaaa gtttttataa tttttttatt 2308801 aatctatcaa gaatacacca gaattattta attttatata aacatggaag attttataac 2308861 acgatatggt tcgtatatgg attgagtctg acagatcatc ttgcaatcca tttcaatttc 2308921 ggataggcac ttctcttgtt ccctcggcat acattaatga tatcttgcaa agaaaaggtg 2308981 atacgatgaa taaatcattt gcagacatgc aaggatttcc tgcgggcttt ccaagcttcc 2309041 ccaactttcc gcagcagtac tatcctgctg tccctccctt ttaccagcaa agccagcagc 2309101 catttggagg ctacggatac ggacagccgt tcagtcaggc atacagcccg ttaaccactc 2309161 cctctggaat gtactcctca ttcccatacg cttcaggatt ttacggacag caattttcag 2309221 gtgcaggctt tagcggccat ggcggcagct taagtgctcc agcgatacat gccggcggat 2309281 tcagcggggc gccaggcgta cacggaggct ttagatatta aagaatacca caagggccga 2309341 acatctattg cggtcctttt attgttttaa aacgacttca caagtacagt cacattttct 2309401 gtctttatat ttggaaacag gatggaatat gattaagatg aattgaacga tattctgcac 2309461 aatccgtaag ttttcgagga ggaataaaat tgcatataaa aatagacgat ttaactggac 2309521 gtcaggtggt ttcactggtg aatgagcatt tacatagcat gacgcttatg tccccgccag 2309581 aaagcattca tgccttaggt ctagaaaaac taagagggcc tgaaataaca ttttggagcg 2309641 catgggaagg tgatgaacta gctggctgcg gagcgctaaa agaactggac acccggcatg 2309701 gagaaatcaa atcaatgcga acatctgcat cacatttaag aaaaggcgtt gccaaacaag 2309761 ttctccagca catcattgaa gaagccgaga agcgaggcta tgagcggtta agcttagaaa 2309821 cgggttcaat ggcttcattt gagccggcaa gaaaattgta tgaaagcttc ggtttccagt 2309881 attgtgaacc gtttgcagac tacggtgaag atccaaacag tgtgtttatg acgaagaaat 2309941 tgtgagacgg ctttataagg atagataagt gcaggggaag gtctgtctta tctatctttt 2310001 tttatattca cacatttttc acctttatga tacacgccaa tgttttcaat tttgtttaat 2310061 tcaaagaaca gcgggaatta caaacgacat gaacgatatc atgcaaattc ataaaggagg 2310121 agattgatat gaaaagcata gttggtgtat atgaaactcc gcaggaaacc atcgcagcga 2310181 ttgaaggctt acttacaaaa ggctatgatt ctgatgacat ttctgttgtg acaagccggc 2310241 gagatacaga ttatttggag tcacgtacag gaacagaagt caatcaagct atcgatgcac 2310301 atcaggacga atctgaatct tttttcgata aactgaaaga ttatttcaca atggatgata 2310361 ctgctacaca cagcaaagca ttatccgact tggatattaa aactgatgaa atagacaagt 2310421 atcaagaaga tttggatgac ggaaaacttc tggtagccgt cgatacagat gcagatgtaa 2310481 ttgctcctat tgataacggc aatgcccttt caggcggctt ttcaagcaca aatgaattgg 2310541 attatacaac gaaagaagaa aaaacgatgc cgctccggga agaacagctg aaggtcgata 2310601 aggaagacgt tcaaaccggc gaagtagaaa taggaaaaga agtgaaaaca gaaaaaagag 2310661 atatggacat tccggtgaga catgatgaaa tttatgtcga acgccgtcca gtggatgaaa 2310721 ataaaacgga cgctgctccc gtcaacgatt cggaagagat cagagttcca atcgttgagg 2310781 aaaagctgga agtgactaaa aaaccggttg tcactgatga agtggttgtc ggcaaacgca 2310841 ctgttgaaga aaatgaacat atttctgaaa ctgtgaaaaa agaagaacct cgtctgaata 2310901 aagaaggaaa agttgacggc ttggatgatg atccgttaaa taacaaatga aaatcataga 2310961 ccgacaacaa aaaacctcaa atcctaaatg gatttgaggt ttttcttttg gtacgtccca 2311021 ggagagattc gaactcccga ccgacggctt agaaggccgt tgctctatcc agctgagcta 2311081 ctgggacacg ttttgttttt ttgtttttcg ctttaactat cagcgacaag atttattata 2311141 tatgggatgc aataataagt caacggtttt ttagaatttt tttcatgagg aagaaaattt 2311201 tcttcctcat gacattttca tagtgtgact cgattttgca gatcctcaat ttcattgcct 2311261 gcttggtcgt aaaaacggac tgtcgcagca tcattttcta atgtcagtat agcatagctt 2311321 tctgtcctgc gcaccctcgg aagccggatg ctgcctgggt taatcatcag ttttccgcgc 2311381 agcacttcgc ttcccgcgat gtgcgaatgc ccgaagcaga taacatccgc cccgagctcc 2311441 tctgcacgat agtatacgtt taacaaggtc tgttttatac cgtgaaggtg gccgtgtgtg 2311501 actagtattt ttcttgagcc ggcagtcaga agaagctcgt ccttaaaatc gccggcaaaa 2311561 tcgcaattgc cttttacaac cgcataaggc tccaatgcag gatgcctcgt ctcaagctca 2311621 gagtccccgc aatgaatcat gagatcaact tctgcctcat gccgtttcgc aatggtttgg 2311681 agttcttctt caagcccatg gctgtcactg ataatcagca cgttcatgta caagcttcct 2311741 ccttatgcct ccaaaagctt agacagcttt ttaagcgcgt cagccctatg gctgatttta 2311801 tttttttcat cacttgtcag ttcagccatc gtcttatctt tatctttcac gataaaaatt 2311861 gggtcatagc caaagccata ttctcctctc ggttcttcag caatataccc ttcaacatgg 2311921 ccttcgactg tttttgtttc ctctccggga atactcacgg ccagtgcgca gcggaaacgg 2311981 gcggtgcgct gttctttttc gatacctttc agctcgctga gcactttttc gatatttgcc 2312041 tggtcgtctt tctgttcccc tgcatagcgg gctgaataaa ccccgggtct gccgccaaga 2312101 ttatcgatgg atagtccgga gtcatccgca atcaccattt tgttcactgc tttggcaaca 2312161 gcttccgctt tcataatggc attttcttca aatgtatggc ctgtttcttc aatttcctct 2312221 gtgaatccaa tttcagctaa agatttgaca tcatagcctc ttggctcaag aatttctttg 2312281 aattccttca cttttcccgg attatgtgtt gcaataattg cttctttcat gatgatcaag 2312341 cctttctgtc tttatttcag ttctggcaga gaatcaccca gcacttcttt ttgcttgtca 2312401 atcagctctt ggattccttt ttccgcaaga cccagaagac cgttcagatc ctctctagaa 2312461 aaagttgcct cttccccggt tccctgcaat tccacaaaac ggccgctgcc tgtcatgatg 2312521 acattcatgt caacttcagc agaggaatct tcttcataat ttaaatctaa caaaattccc 2312581 tgttccttat caattccaac agagattgca gcaagaaaat cagtgatcgg atttgtcttg 2312641 attgttcctg ctttgatcag cttgccaatc gcaatcgcca tagcaagaaa tgcgcctgta 2312701 atggaagctg ttctagttcc tccatcagct tgaatgacat cacagtcaat ccaaatcgtc 2312761 cgttcaccga gcttttccag atctacaaca gctcgaagcg cgcggccgat caggcgttgg 2312821 atctccattg ttctgccgga aattttcccc ttagaagatt ctctgattgt tctttggttt 2312881 gttgcccgcg gcagcatgct gtactctgct gtaatccagc ctttccctcc gccccgcaaa 2312941 aacggcggta cgcggtcctc aacagacgcg ttgcagatta cctttgtatt tcccgctgtt 2313001 attagaacag aaccttccgg atggctgata aaatccaaat cgaatgtgat tggacgcagc 2313061 tcatcgtgtt gtcttccgtc atgtctcatg ttttacctcc gattgtatgt acataaacca 2313121 tttttgtccc ggaattgaat aaagaaagag gcagccggaa cgctaacctc tttcttccta 2313181 gtatatcaaa aatcccaatt taaaaactac ccgtattcac ttgagatggt ctggagaccg 2313241 gttctgtgag cttttcgcct ttttcattta ccagctctga ttttccgttc actttaacag 2313301 agacgctttt tacatccggc tgctccgtta acgtcagcac aatgctgttc agcacttctg 2313361 aagaaatcat tttcgtcttc tcatcggcgc tgccgaatat agattgattg aaatccaacg 2313421 tcacgcgccc gtctttgatt ttcggtttgc tgaccagctt tacatcttca ctgaagtctg 2313481 ttaacagccc gctcaccttg ctcggccctt tagccaattc attaatggct gctgtgatgt 2313541 cgtctttttc cgaattgtcg attcgtttgg tcaccggcac gtagtattca ctgtcttcat 2313601 tttccgccaa atagtagact gtcagcggat gggtagcagt gagatcattt acaccggctg 2313661 tttccaaatt aatgccgtct ttgcggctta aatcatctga gatcggcgtc cctcctacag 2313721 gcatctcctt cagttcatgc ccgtttattc tcagcttcac tttatctatc gaactaaatt 2313781 gcgtcagcgt ccacgtcaca gattgaacga ttttctgttc gtcttctttc ttataatttt 2313841 tgaactcatt agagaaatca gctatcgccg ttccatcttt tttgatgtca acgttaacgg 2313901 tggtgtcagc cggcaataca gctctgaagc cattcggaag aatttcagac acaggcccgc 2313961 cctgtacgag gtattcaagc gcctgcttag ccgtgctctc acttttagga agaggcagcg 2314021 tttgcgcaac aacatacccg tttttatcaa tgagataaag ctccctcata acagtagatg 2314081 aggcttgatc cgcttttgcg gtatcgcttt tttcactttc tgtttttttg gctgctgttg 2314141 tatttgaatt ggcacccgct tcatcgttca cgaatgtaac gtcttgaggc ggatcaattt 2314201 cctcggctgc cttatcagat tgaaacaaac cgcatccgga taaaagcaag gcagaggtga 2314261 gacaagtggc accaatgact gcaggtcctt ttttcagcat acttttccct cctaaggatg 2314321 tttgtactat tatgtatacg agcctcttta ggaaatagac cgaagaattc cggcaaaaca 2314381 gaaaaaaacc cgcaacatac cgttgcgggg aaaactatct tttaatcggt tcttgcagtg 2314441 agatacattc cacatgcccg acttcatggc caaaccaatc gtctgcgatt tttgcaaact 2314501 gatcacgcgc ccctgttgtc aggaactgat gatccggggc aatcggagac tggttcagca 2314561 gccctttata agagagaatt gtgctgactt cccgggctgt ttcatcgccg gacgaaataa 2314621 tgtttacgtg ctctcccata tatctttgaa tggcttcttt taaaataggg taatgggtgc 2314681 agcctaaaat cagcgaatca attgatgtgt cttttaacgg atacagcgag gttttaacaa 2314741 tctcgtctgc tgttttgtcg agaaacttcc cgctttccac aaaaggcaca agcagcgggc 2314801 aggcaaggtt ttcaaccttc aaatcagggt ttaatgccaa aagcgcttct tcgtatgcat 2314861 tgctcttaat cgtattctct gtgccgatga caccgatatg ctgattatcc gtcactttta 2314921 tcgctgctct cgcaccaggc tggatgactc cgaccaccgg tataccgacg ctgcgctgga 2314981 tgtcatccaa agcgatcgct gttgctgtat tacaggcgat cacgagcatt ttgatgtggt 2315041 ggttttcgag taaataattc gtcagctccc acgtatattg aagcacctct tcttcagggc 2315101 gcggcccgta aggacaccgt ttcgtatccc cgacgtagat aatattttct ttaggtagct 2315161 gtctcatgat ttccttcgca acggttaaac cgccaacccc ggaatcaatg actcctattg 2315221 gttgttccaa caaaatcgcc tcattttctc ttcatttcat gctgcagttt catcaaagat 2315281 ttttcgaaga tggctatttc ttcatctgta aacgattcga acatatcacg cagatattcc 2315341 tgtctttttg taatgacctc ttggataatc cgttctcctt caggcagcag atgtatcctg 2315401 acaacacgtc tgtccgccgg gtccttgacc cgctcaacaa gctcattttt ttgcatgcgg 2315461 tcgattaagt ccgttgtcgt gctgcatgcc agatacattt tgcccgataa ttcaccgatt 2315521 gtcatatctc ctaattcata aagccattgc aagccgacaa attgcggcgg cgtaatcgca 2315581 tattggttaa ggatttctcg tcctttttgc ttaatgatcg cggcaatgtg gcggagtgac 2315641 ttttcaatat ccgcaacatg ctccaaaggt tttgatgtca tttgtccatc cctcactcaa 2315701 ggatctctta cgcacaaaag cgttccgtgt ctattttcct tcttttttga agaaaatgca 2315761 agactcgcag gagagaaata gaggacttta gtcaaacaac atcaagaaat aaaatttaat 2315821 ttatgacttg cctacgtttt gcacagcatt ccaaatatgg tttcgaatgt tccaaacaaa 2315881 cagcaataac cggctccttc caaaagaagg aataccggca aggattaaag ctctagctca 2315941 cccattctaa gaagctcaac aacggcttgc gaacgccctt tcacacccaa tttctgcatg 2316001 gcatttgaaa tatggtttcg aacggttttc tcactgataa atagctcgct tgcaatctcc 2316061 tttgttgtct tatcttgaac gagcaattcg aacacttctc tttctctttt cgttagcagc 2316121 ggcttcgatt gaaattcttt ctccttcaag tattgtaacc ctccttgcta aggtgagagc 2316181 gaatcagaaa cgaatgggtt ttgatatagt cgagatatca tatgtaagaa gggcgcagga 2316241 ggtgacgttt acaagataat tagtttatcg tgtatgaaga agcgtttctt tctcctcatc 2316301 cgtccagctg acagccttgc cgctttcctt tgagacttga accatcacga ctgccccggt 2316361 gaagcagggt tcgccttcga ggttctctcc gagatagtgc aaggtaagag atgaactgcc 2316421 gactgcgctt gttttcacat agatgcgcaa ctcttcataa ggcatgactt ggcgcaaata 2316481 atcgcattgc tggcttgcca cgactgtcat ggtctgtttg ttttcactca tcatattcag 2316541 ctttttaaaa taagaaatcc gcacctcctc aaaatatata aaaggggtta cattattcat 2316601 atgcccaaac atgtctgtct cggaaaatct tacggatacc ttattgaaaa aagaaaagga 2316661 tgttttccat tcttgaaacg gcatatcaat ataagcggga agcttcatct tttttcatct 2316721 ccttattgtt taaaaaaacc tctcccatgc ggaagaggtt ttttcttctt atactctgtc 2316781 gcttccgaag aaattgcgga acgcttgtaa gtttgtatct ctattcaagg ctgcaatcga 2316841 agtggtaagc ggaatcccct tcggacagga ttgaacacag ttttgcgagt tgccgcaatc 2316901 tgcaaggccg ccttcatcca ttaatgcttc taatcgttca gatttattca tggcgcctgt 2316961 cggatgcgcg ttaaacaggc ggacttgcga catcggtgca ggccccatga acttcgattt 2317021 gctgttcaca ttcgggcaag cttcgaggca gacgccgcat gtcatgcatt ttgataattc 2317081 atatgcccat tgacgacgtt tttccggcat tctcggcccc ggtcctaaat cgtacgtacc 2317141 gtcaatcggt atccacgctt ttactttttt caatgaatca aacattctgc tgcgatcaac 2317201 ctgcaaatca cgaacgactg ggaatgtttt cattggtttt aaacggattg gctgttcaag 2317261 ctggtcaata agcgccgtac aagactggcg gggttttccg tttataacca ttgaacatgc 2317321 gccgcatact tcctcaagac agttcatatc ccatgtgaca ggggttgtct tctcaccttt 2317381 gacattaacc ggattccggc ggatttccat cagagcggaa atgacgttca gattcgggcg 2317441 gtatggaatc tcaaattctt catcataagg cgtgctgtca gctgtatctt gacgtgtgat 2317501 aataaatcgt atggtttttt gttcactcat gattatttcg ccaccttctt cttcgagtaa 2317561 tcccgtttcc gaggcgttat cagtgataca tcgacatcct gatactcaaa ttccggcgct 2317621 tcatacgggc ttacatgttt agccattgtt gttttgagcc attcatcatc attacgttca 2317681 ggataatccg gtttataatg ggcgccccgg ctttcattac ggttgtatgc gccaagggta 2317741 atcaccctcg caagctgaag catgttcgag aactggcgtg tgaacatcgc tccctggttg 2317801 ctccattttg tcgtgtcatt gatgttgatc tttttgaagc gctccattaa ctcctgaatt 2317861 ttgtcatccg ttttcaaaag cttgtcatta tggcggacaa ccgttacgtt cgccgtcatc 2317921 cactcaccga gctctttgtg aagaacatag gcattttcgg ttccgtccat actcataata 2317981 tcagcccatt tttcttcttc tttcttaacg tgagcgtcga ataaagatga agacatgtct 2318041 tccgctgaag attctaagcc gtttacatat ttcaccgcat tcggaccggc caccatgcct 2318101 ccgtaaatcg cagacagcag ggagttcgct cccaagcggt tgccgccgtg catagaataa 2318161 tcacattccc cagccgcaaa cagtccaggg atatttgtca tttgatcgta atccacccat 2318221 aaaccgccca tagaataatg gaccgccggg aagattttca ttggaagctt acgcgggtcg 2318281 tctcccatga atttctcata aatctcaatg atgccgccaa gcttaatatc aagctctttc 2318341 ggatctttat gagacagatc gagatatacc atgttttcac cgttaatacc gagcttctgg 2318401 ttcacacaca catcaaatat ttcgcgtgtc gcaatatcac gcggcaccag gtttccgtat 2318461 gccggatatt tttcctccag gaaataccat ggtttgccgt ctttatatgt ccacacgcgc 2318521 ccgccttcac cacgcgctga ttcactcatc agtcttagtt tgtcatcgcc cggtatggct 2318581 gtcgggtgga tttgaatgaa ttctccgttt gcataatacg ctccctgctg ataaacgatt 2318641 gacgcagcag atcctgtatt aatcatggag ttcgttgatt ttccaaagat gattcccggt 2318701 ccgcccgtcg ccataatgac agcgtctgaa cggaaggatt caatttgcat gtttgtcagg 2318761 ttttgtgcaa caattccgcg gcaggttctg tcatcatcta aaacagcgcc aaggaattcc 2318821 cagccttcgt attttgtgac cagacccgca acttcgtatc tgcgcacttg ctcgtccagt 2318881 gcgtaaagca gctgctgtcc cgtcgtcgca ccagcataag cagttctgtg gtgctgtgta 2318941 cccccgaatc ggcggaaatc aagcaggcct tcaggcgtcc ggttaaacat gacgcccatc 2319001 cggtctaata agtggatgat cgaaggcgcc gcttcacaca tcgccttgac cggcggctgg 2319061 ttggcaagaa agtctccccc gtataccgtg tcatcaaaat gttcccacgg agagtcacct 2319121 tccccttttg tattgaccgc tccgtttatg ccgccttgcg cacaaactga atgagaacgt 2319181 ttgacaggaa cgatggaaaa caatttaacc gccattcctg attccgctgc tttaattgtc 2319241 gccatgaggc cggcaagacc cccgccgact acgataatgc ttgattgact catgatagcc 2319301 cctctccctc tagtaatcta gtactcttaa acaaatgcaa aaatcgcttt taagcctacg 2319361 tatgacagtg caacaaaaat aatcagcgta acgtatgtcg aaattctttg agaacgaggc 2319421 gttaccgtga tgccccatgt aacagcgaaa gaccataaac cgttcgagaa gtggaaaatt 2319481 gttgataaaa caccgacaat gtaaaaacca agcatagccg gagagctcaa aatattcgcc 2319541 atcatgtcga aattgacctc agcacccatt tgtgcggcaa tgcgggtttc ccacacgtgc 2319601 cagctgacga aaatgagggt gatgataccg gttacacgct gcaggacgaa tagccagttt 2319661 ctcatgtagc tgtattgacc ggcgttattt ttcgcagtaa acgctatgta cacaccataa 2319721 actgcatgat aaattaatgg taagaagata ataaaaattt ccaaggcata cctgaaaggc 2319781 aggctatcca taaaatgagc agcgctattg aatgcttcag cgccccttgc ggcaaactgg 2319841 ttgacgacta aatgctgaat aagaaagatg ccgaccggta tgacgccaag caaggaatgc 2319901 aatcttcgaa aataaaactc tctgttccca gacattactt taccccctgt ttgataagtg 2319961 cgaaatgtgc taaatctctt cccccacttc tttcaattgt aagcacttta ttaagattta 2320021 ttgacaattt cattttactc ctccctcaaa agggcgtcaa gaaaacgcgt acataaatta 2320081 taattttccg aattgattag ttgattgaaa aattttattt tatcaatata tatttcttgc 2320141 ttaatttttc ataagaatta caggatcatt ctgtaatcct cccccctgtt tgagctataa 2320201 tatacgcagg agagagggga gacagatatg aagtctaaat ttgaagcatc tattgacaac 2320261 ctaaaagaaa ttgaaatgaa cgcttatgcc tacgaactaa tacgagagat cgttctccca 2320321 gatatgcttg gccaagatta ctcttccatg atgtattggg caggaaaaca tctcgcccgt 2320381 aagtttcctc ttgaatcatg ggaggaattt ccggccttct ttgaagaagc gggctgggga 2320441 accctcacca acgtaagcgc taaaaaacag gagcttgaat ttgaacttga agggccgatc 2320501 atttccaacc ggcttaagca tcagaaagaa ccttgctttc agctggaggc tggttttatc 2320561 gctgaacaaa ttcaattgat gaatgatcag attgccgaat catatgaaca agtgaaaaag 2320621 agagccgata aagtggttct gactgtgaaa tgggatatga aagacccagt gtaatcaaaa 2320681 aggcggtgac tgcatagtcc cgcctttttg attgtcatta cacagctgaa gggtgttttg 2320741 aaagctcaaa tgcatcgtga agcgactcga ctgctttcac catgtcattt tcgcttacga 2320801 ctgttgacac tttgatttca gatgtgctga ccattttgat taaaatgttt ttttgcgcca 2320861 gtacagcaaa catttcagcc gctacaccgg gatttgagac catgccggat ccaacaatag 2320921 atactttagc caatttgctt tctgtctcga ttttctcaaa ttccagcgcg tctttatact 2320981 cttcaagcac cgcaacggtt tggtctgcat cttctgtttt gacagagaag gaaattccag 2321041 tcttgtcctc ggcctgcgtt tggataatga tatccacgtt tatgtttctt ttggcaagtg 2321101 ttgtaaaaat agtagacaaa gttgtcaggc cgctagtcag cccgtaaatg gttactcttg 2321161 tgatttgatc ttcaaatgca atgcctctga caattaaatt ctgttccatg gatgattcct 2321221 cctcaattaa tgttcccgct tcggtttctg tacttgaacg cacttctaac ggcacttggt 2321281 aatttttcgc gaactcaact gctctcggat gaagaacacc ggcgcctaaa ttggcaagct 2321341 caagcatttc atcgtatgag atgccctcaa gttttctcgc tgatttcaca tagcgcggat 2321401 cggttgtaaa cacgcctggc acgtctgtgt atatgtcaca tttatcagct tttaaagcgg 2321461 cagccaaagc aactgctgtt gtatctgaac cgccccggcc caatgtcgta atttcacaat 2321521 cctctgtcat gccttggaat cctgcaacaa tgacaatttt tcctttttca agctggtctg 2321581 ctaaaaccga agtgtcgata tctgtaattc tggcgtttcc gtgaatggcc tccgtacgga 2321641 ttcccgcctg ccagccagta taagacacag cgtcatagcc tttttcctgc aatgccattg 2321701 aaaggagtga aatcgtgacc tgctcgcctg tcgccagcag catatccatt tcgcgtttgc 2321761 tcggctggtc agaaatagct tttgcaaggc tgaccaattc gtcagtggat tttcccattg 2321821 ctgaaacgac gacaacgact tgatggcctt tctgtttttc tgcaattgcg cggtttgccg 2321881 cattttgaat tttttcgact gagccgacgg aagtgcctcc gaatttttgt acaataagac 2321941 ccatgtatta ccacccttta cattttggtt cgtgcgggtg aggagaaaga gcgctttgtc 2322001 cacaataaaa aaagcaatga gaggaatact ctcattgctt atcaattaat catcataaat 2322061 gattatgaac aacgagatag ccctccaaga aaatgatttc ttgacagcct tacatttatt 2322121 caatgcacgg ccagcaaata ataccgatgg ggttttattt gcttcggcga cgctcccctt 2322181 tcagcctttt tcacagaatc catctttctc caaaggcata ctcttgaagt tcgcacctct 2322241 atcttcacca tataacacga tctaactatg aaattagttc acattttatc agatcttatt 2322301 taaaaggaca acattatttt tgcaatttgt cgtaaaggag ctgagccgcc gctgcgggaa 2322361 caccggcttt tttgatgtcc tcaaggcttg cttccttcat ttttttaacg gaaccgaaat 2322421 gctttaacag cattttcttt cttttctctc cgatacccgg gatgtcgtcc aaaacggatt 2322481 gaaacgcgct ttttccccgg atttgcctgt gaaaactgat tgcaaaacgg tgcacctcgt 2322541 cctgaatgcg ctgcaggagg taaaattcct ggctgtttcg ttccagatac gccacctcca 2322601 gcggatcacc gatcagtaaa tttgaggttc tgtgtttttc atctttcgct aaaccggcga 2322661 tcgggatatc caagccgagt tcattttcaa tgacatccct tgctgcgttg atctgccctt 2322721 ttcctccgtc aatgataatc agatcgggca gcggcagatt ctcacgaagc actctcgtat 2322781 agcgtcttct gacaacctct ctcatagaac cgtaatcatc cggccctgta acagttttga 2322841 ttttatattt gcggtattcc tttttgtatg gtttgccatc gataaacaca atcatcgcgg 2322901 aaaccgggtt tgtcccctgt atatttgagt tatcaaacgc ttcaattctg tgcggcgtat 2322961 aaatatttaa tgcctcacct agtttctgca ctgccccgat tgaacgctcc tcgtcccgtt 2323021 cgattaaaga gaatttttct ttcaatgcga ttttcgcatt tttatgggca agcatgagca 2323081 gttctttttt cgggcctttt ttcggctggt gaacgtttgt ttccagtagc tgctcgatca 2323141 tagattgatc tatgctgtcc ggaactaaaa tctccttcgg aaggaagtgg ttgttttttg 2323201 aatagaactg cccgatgaac gtgaggaact cttcatctgc ttcctgataa agcgggaaca 2323261 tgctgacatc gcgttcaatg agctttcctt ggcggatgaa aaagacctgc acgcacatcc 2323321 agcccttatc gtacgcgtac gcgaacacat cacggtcgac tagatcgttc atcgtcattt 2323381 tttgtttttc catcgttgat tcaatatggg caatttggtc acgaagctct tttgctcgtt 2323441 caaactcaag attctcagca gcttcatgca ttttctcttc aagctctttt ttgacctcat 2323501 tatagccgcc ccttaagaaa cgtgtaatgc tttcaaccag ctctctgttc gtctcttcgg 2323561 aaatatcctt tacacacgga gcaaggcatt ggcccagatg atagtaaagg cacactctgt 2323621 ccgggagctt ggagcatttt ctgagaggat acagacggtc gagcagtttt tttgtttccc 2323681 ttgctgcctg tacattcgga tacggcccga aatagcgccc tttgtctttt ttgacattgc 2323741 gggtgacaat cagccttggg tggcgttcat gggtgagttt tatgaaagga taggttttgt 2323801 cgtctttgag catgacgttg tatttcggat catgcttttt gatcagattc atttctaaaa 2323861 taagcgcttc aagattggag gacgtcacaa tatattcaaa atcctcgatt tccgtcacaa 2323921 gcctttgggt tttcgcgtcg tgagaaccgg tgaagtagga gcgcactctg tttttcagca 2323981 cttttgcttt ccctacgtag atcacagtct gctgccggtc cttcatgaga taacaacccg 2324041 gttgatcagg aaggagggcg agtttttctt tcagttgttt gttcatatgt tacccttcct 2324101 tatgtttaat cctttatttc cagtttaaca cgaacgtttg tttttctcta tggttcacaa 2324161 ttggcgaata aaaaaagcga tccctcaatc ggaatcgctc tggcatgtaa gcagcggaaa 2324221 attaaagatg tttgtttaca agctcttgaa gcgcttcttt tggtttgaag ccgactgaag 2324281 tttcaactac ttcgccgtct tttaacacaa gaagagtcgg gatgctcata acgccgtatt 2324341 ttccggcagt ttcttggttt tcgtctacat cgatttttac gattttcagt ttgtctccca 2324401 tttcttgatc caattcttca agaacaggtg caatcatttt acaaggtccg caccaaggag 2324461 cccagaagtc tgccagtacg acgccttcgc ttgtttcagc tgagaaagat tgatcagttg 2324521 cttttacgat agccattatt gaattcctcc aatgtgaaat gatgattttt agtatagcat 2324581 ctcccattcg ttcacgctat tttaatgctt acaaattatt ttttcctgat cacagccggt 2324641 ttactcattt ttatatggtt gaatgggata tgctcttttt ttaaaacaca aatctgataa 2324701 tggccccgat cactacaatt gccccaataa tcattaaaat ggtacgaagc ataagatcac 2324761 atctcctctt cactgtcatg tactttacca tgccctgccg gagctgtttt aaaacctgaa 2324821 aaagagcgcc ggcatgaagc tccggcgctc ttgcgcgatt aagaatcagc acgcagcgta 2324881 agtaagacga ctgacattgg cgggagtttt actttcagtt tgtttttgct gagcgtgtat 2324941 tgtctgaagg attccggttt gacatgatga ggatcgtcaa acgtgttatg cgcattcatt 2325001 ttttctgccg taagaatgac tccggaatgg tccgctgcct tgtgtaggcc cctcagctcg 2325061 atttccgcct ctgctttgtt ttggtgatcg atgttgcaaa ttgtgatatt gatatcgcct 2325121 tcagcttgtt tcgacgctga aatgctgatt tgcggaagcg tttcaccgtt ccattcatag 2325181 tcggcagaca ttgtctctgt ggctaaaaga gaagcgtcct ggtgcacctt aaacatattg 2325241 aatacatggt acgtcggtgt caaaagcatc cgctctccct cagtcaaaat catcgcttga 2325301 agaacattta ctgtttgggc gatgttggcc atttgcaccc ggcggcaatg ctgatggaaa 2325361 atgtggaaat gagaagccgc caccagtgca tcacgaatgg tgttttgctg atataagaaa 2325421 ccgggattcg tgcctggctc gggatcaaac cacgtgcccc attcatcaat aatcagcccg 2325481 acccgctgct ccggatcgta ccggtccata atcgtgccgt gtttttgaat caattcatcg 2325541 atgtatttgg cttttttcat cgtaataaac cattcatctt ccgtgaattc tgtggctgat 2325601 cctttgccct tccagaaatc ccccggaatc gtgtaataat gaagactcaa cccgtccatc 2325661 aggccagcgg cttttttcat aagcacgtcc gtccaattaa aatcatccac atttgcgccg 2325721 cctgcaattt tataaatgtc attcccgctg taattgcgga cataagtctg aaaacgccgg 2325781 tacagatctg cgtagtattc gggatgcatg ttgccgccgc agccccagtt ttcattgccc 2325841 acgccgaaat atttcagctt ccaaggctct tctcttccat tttgctttct ccagtctgac 2325901 atcggcgtgc cttcttcaaa tgtcatatac tcaatccact ccgacatttc ctgaacggtt 2325961 ccgcttccga cattgccgca aatatatggc tcgcattcaa gcagctcgca aagcatcata 2326021 aattcatgcg ttccgaattc atttgattca attgtaccgc cccagtgagt gttcagcatt 2326081 gtcttacggt caccgacacc gtttgcccaa tggtattcgt ccgcaaaaca cccgcccggc 2326141 cacctaagga caggaatgtg cagctgtttg agcgcctcca gcacgtcctt tcgtatcccg 2326201 ttgatattgg ggatgtctga gtccgttccg acccagatcc cctcataaat ccctcttcct 2326261 aaatgctcag caaaatgacc gtatatattt ttgttaatgg ttccttttgc gatatctgtt 2326321 tgaatcactg cttgatgttc agacatgcct ctgatcattc ctttcatacg gatatgaaaa 2326381 gcaccacagt caaatatgtg atctgtcgtt tgcctgagga gtcagcatga atgtaagcgc 2326441 ttttaaagta accatattat atatgttcgt acatgtcaac gacattttct attgttttta 2326501 tatttgtacg tatgtattta taaatatgaa aaaacccgga cttttaaagt ccgggatttc 2326561 ctttatgagt gtatattcag ctgtttgaat tcctcagtta ataacgggac aacttcaaat 2326621 aaatcaccga cgatgccgta atccgctatt ttaaagatat cggcttcggg gtctttattg 2326681 atggcgacga tcaccttgct gtttgacatg ccggccaaat gctggatggc gccggaaatg 2326741 ccgcatgcaa tgtacaaatc cggagtaacg actttcccgg tctgcccgat ttggagagca 2326801 taatcgcaat aatcagcgtc acatgccccg cgagaagccc cgactgcggc ccctagcacc 2326861 tctgcaagct cctgcagcgg ctgaaatcct tccttgcttt tgactcctcg gccgcccgca 2326921 acgataattt tcgcttcgga gagatcaaca ccgtccgccg tttttttcac gacctcttgg 2326981 ataacagtgc ggaggtcagt aagagaaaca tcaatgcttt cgatgctccc cgatctgctg 2327041 gtgtcttttt ctgaagcttg aatgttattg gggcgaattg ttgcaaagat catcggatcg 2327101 gttgaaatga cgcgttcaaa agctttcccc gagtaaatcg gccgtgtgaa cacaacattc 2327161 cctccggtaa cgcttacatc tatagcatca gaaattaagc ctgtttgcag acgggcagca 2327221 agcttcggtg aaagatcctt gcccattgcc gtatgcccga agatgactga atcaggattt 2327281 tcttgctcga taacacctct catgacctgg ctgtacccgt ctgccgtgta tgttttcagc 2327341 ttcgggtcct cagcggtaag aactttatct gctccgtaat gaataagctc ttgtgcaatg 2327401 ctttgtacat tttcaccgat gagaacaccg atgacttccc catctcctga aatggttctt 2327461 cctgcagcta ttgcttcaaa ggtgacattt cgcaattccc catcgcgtat ttctccaagc 2327521 acgatcactt tttttcccat tctaacatcc ccctgtttct ttgaatgtcc aagttttaaa 2327581 tgactttagc ttcgctgcgg agcaatgaaa caagctcttt tgcctgttca gcaggctcac 2327641 cttggagaag cttcccggct tcttttttcg gcggcagaaa acgttcaatg gttttcagct 2327701 ttggttcagc atcctcttcg tccagatcaa gatcatcaag ttcaagctct tcaagcggct 2327761 ttttcttagc cttcataatt cccggaagcg atggatagcg cggctcgttt aagccctgct 2327821 gagctgtgac aagcaatggg agcgtcgttt tgattttttc aacatcccct tcgacgtccc 2327881 tttctgcttc tgcatcagtg ccgttgattt cgagtttggt gatcgtagtg atacacggaa 2327941 tgtccagtag ctcggcaagc cgaggcgcca cttgtcctga tcctccgtca atggcaacat 2328001 ttccgccgag aatcaaatca aactcctgat ccttcatata gtggtataaa acttgagaaa 2328061 tggaatattg gtcgggttca tcaagatcat cttctatgtt gattaaaaca gcttggtcac 2328121 aacccatggc aagcgccgta cgcaattctt tctccgcttc ttcaccgccg accgtgacag 2328181 cggtgatcgt gccgccatgc ttttccttca gctggatggc ttcttctatc gcgtactcat 2328241 catatggatt aatgatccat tccgctccgt catcctgaat ctttcctgtt tcaatgacga 2328301 ttttttcttc tgtgtcaaac gtccgtttca tcagtacaaa tagattcatg atcatatccc 2328361 cttttattcg cctttgaact gaggctttct tttttcgaga aatgcctgga tgccttcctt 2328421 ggcgtcctct gactcaaatg cttccccaaa tcgctttgct tcaagcttta agctgccttc 2328481 ataggaatac accttgttgg aataaagaag ttcaagcaaa gatgccagcg tttgcgggct 2328541 tttctctgca aacttagcgg caagtgcttt tgctttttca atcacttctg cctcatcttt 2328601 cgctccaatt gagacaagtc cgagatcaag cgcttctttt ccggatatcg gttctcctga 2328661 tccgatgagc tccagtgctt tggctgtacc gacatatctc ggaaggcgct gtgtccccgc 2328721 aaaacctgga atgataccga gattaagctc cgggagcccc agcttagcat cttctgccgc 2328781 gattctgatg tgacaggcca ttgcaagctc cagcccgcct ccgagagcag cgccgtgaat 2328841 cgctgcgata atcggttttg gaaaactttc gattctctcc attaactgct ggccgcgctc 2328901 agcgagcaat gaggaatcct cattgccttt aagcgatgta aattctttaa tatcagcgcc 2328961 ggctgagaaa aatcttccct cgccgtgaat gataatgctt cgtacgcctg catctgtctc 2329021 acattgatca agacaggaag acagctcttc taatatccgg cttgaaagcg cgtttgccgg 2329081 cggattgtga atcgtcaaga ctgccacaaa ttgatcaacc gcaagtgaaa ttgcattcat 2329141 aggacagaac tcctttactt attgtgaatt ccggatacca ataattctaa aacgctgttt 2329201 gaaagcgcaa cgagatcgta cttttggtca ttcatcaccc aagttgtcac agtttcgtca 2329261 atcgttccaa aaatcatctg ccgggcgagg cggacatcga ggccttcttt tatttcgcct 2329321 gattgtatac cttccgtcaa aatgccatcc aaaatattta agtagccttt taatatttcg 2329381 ttgatttttt ggcgcagctc caagttggat tggcggagct caagctgcgt gacaatggcg 2329441 agattatggt cacccgctaa aagggaaaaa tgctttgaaa tcacaagcgc caatttctct 2329501 ttcgctgttg ctttttcttt aatgtcctct tccatccgct caataaattg acccattttt 2329561 tctttgaaaa gagaaattaa aatatcttct ttgtttttaa aatagagata gatggtgccg 2329621 tccgctaccc cggcttgttt ggcaattttg gatacctgtg actggtggta gccgttttct 2329681 gcaatgactt ctactgctgc atcaataatc tgcatatact ttggccgttt ttgcttcaat 2329741 gttcatcgtt ccttcctata gaaatgaatg actattcatt cataatttca tgataagaag 2329801 gattttcagg tttgtcaagt ttattcatag gcgttctctt tttttatttg atatgatgat 2329861 tttcggtttc ttcttcaagt aaacgccttc ttaaaatttt tcccaccgcc gttttcggca 2329921 gctcctttct gaactcatag gctttgggca ccttataggg agctagacgt gatctcgcaa 2329981 aagcgtccag ttcttctgta tcggcttttg cgcctttctt taatacgaca aatgctttta 2330041 ctgtttctcc cctgtaggaa tcgggaacgc ctgcgacaac aatttcctgg atggcttcat 2330101 gttcataaag cgcttcttct acctcacgcg ggtaaatatt gtaaccgccg gcaatgatga 2330161 tatccttctt cctgtcagca atatagaaaa agccttcttc atccatatag cccatgtccc 2330221 cggtgaacag ccagccatct ctcagcactg cggcggtttc ctctggttta ttccagtatc 2330281 ctttcatgac ttgcggacct tttacaatga tttctccatg ctcatacgga gcggcaagct 2330341 cacccgtctc ttcagaatag atcgcagcgt ccgtactcgg ccaaggacag ccgatactgc 2330401 ccggcttgtt ttttccccag ataaagttgg cgtgcgtcac tggggatgcc tcagacaaac 2330461 catagccttc cacaagcttt ccaccagtca ccttttcaaa tttctgcttt acctccacgg 2330521 ggagcgcggc tgatccgcta agacagcttt taatggatga cagatcataa tgctgcaatt 2330581 cagggtgatg caaaaggcca atgtaaattg tcggtgcgcc aggaaagagc gtcggtttgt 2330641 gtttgtcgat gattttaagt gtttcgagcg gatcaaactt aggaagaaga atcatttcga 2330701 agcctagttt aatcgaatag ttcatgactg ccgtcagtcc gtagacatga aaaaatggaa 2330761 cgatgcccag cactttttca gcgccttctt tcacgtcata catccaagcg gcgcacattt 2330821 cagtatttgc caaaatattt tggtgcgtga gcatgacccc ttttggagct ccggttgttc 2330881 ctccggtata ctggaggaca gcgatatcat gctcaggatc gatcttcggg attgtcagga 2330941 gttcagtttt ttcctgcttc atacaggaag cgaacgtgtg aatgttagct gttttgtcaa 2331001 agtcgatatg cactttttgt ttttgcgtca gcgggtaaag aatatttttc ggaaaaggca 2331061 aatagtcttt tacactggtt atcaaaatct ggtcgactat tgataacgtt ttcattttta 2331121 ttgccttcgg gaaaagcaaa tctaaggtga tgattacact tacctgagca tctctaagct 2331181 ggtattcaag ctcatgctcg gtataaagcg gattcgtctg caccacgatg ccaccggcaa 2331241 acaagacgcc ataataagaa atcactgttt gcgggcaatt gggcagcata acagccactc 2331301 tgtctccttt ttgcaggcca ttgcactgca aaaaagctgc aagtttaaga gcatccgtca 2331361 gaatgtcatg aaaggtgagt ttttttccat aaaacgatat tgcggtttta tcagggaatc 2331421 gtgcggcgga gtctgtcagg atggattgca gggttttatt cggcaacgga agctcatgcg 2331481 ggatatcgtt gggatactcg gcaagccacg gcttttgaga ctgcataaaa cctccccttt 2331541 cgattttaga gatccacctt atcattatag cagatggacg gcaaaaaaaa gaaaaagaaa 2331601 ggtaaatctt tctttttctc ataatatgaa cagatatata agaccaatta acaaaaagat 2331661 tcccgctgcg gcgagcagta ttttcgcaag cttttccatc tattctccgt ccccttatat 2331721 tccggctgcc accacaaaag aaagcccgac agaaatgaca aatgaaataa agccgacagc 2331781 ccggttatca ttttcgattt cctgatcaat tttaaaccgc ggagtcaaaa actcaaaaat 2331841 aaagtagctg atcagaagca taacaaaccc gtaaacgccc cagccgatca tttgcagcag 2331901 cgaattatgc tgggagatgg aatgctgaaa tacgtttgcg attcccaaaa tttttccgcc 2331961 ggtcgccatt gccaccgcaa gatttccttt ttgaatctct tcccagtttt tataagccgt 2332021 caccagctca aacacagtca aaaagaggac gaggcagaga accgcgacac tgtaatatgc 2332081 cgcgatttcc acaagctcgt tttcccaaaa atcactcatg gccatactcc cttttatttt 2332141 agttcaacaa ccgtaacgcc tgatcctccc tcacctgctt caccgaaacg ggaacttttg 2332201 acgctgcggt ggtttttcag aagatcctgt acgccttttc ttaaagcgcc ggttcctttt 2332261 ccgtggatga ttgacactct tggatatccg gctaacaccg catcatccaa gtatttttca 2332321 acccggctga gggcattttc atagcgttcg ccgcgaagat caagttcaag cgatacgtga 2332381 tagtcctttc ctttgaccgc tgtaatcatt ttttcttttt ttggctccgg agctgatttg 2332441 ataaactcca gatctttttc ttttactttc atctttaaaa taccgatttg aacgttccat 2332501 tcattgccgc ctgttttttc gagcaatgtt cctttttgcc cgaaagtgag gactttcacc 2332561 tcgtcgccag gcttaaagtc gcgtttttgc gttttcggct tttccggttt cttggacttt 2332621 tcaaaagcag gcatagcgcc ttctaaccgt ttcttcgcgt taatcagctc gtgatccttg 2332681 aaggatttgt gttcttcttt tatggtgcgc aattcatgaa taatgtcctc ggcttctttc 2332741 attgccgctt ttactttttc agcagcctgc tgttctgcct cttcaagcat tttgtctttt 2332801 ttgctgttaa gctcgatgat ttgctgctgc agctctttat gcagtttttc cgcttctttt 2332861 ctgattgatt ctgtctcaga aagctcttct tccgcacgtt ttttgctttg ttccagcgac 2332921 gcaatcatcg tatcgacttc gttatgctcg gccgtcattt ctgacttcgc ctgcccgatg 2332981 atatggtccg ggagcccgag gcgttttgaa atttcgaaag cattgcttcg acccggcaca 2333041 ccaattaaaa gtttataggt cggtgacagc gtttcgatgt caaattcaac gctggcattc 2333101 atgacgcctt ctctgttata gccgtacgcc ttcaattccg gataatgcgt cgtagctaac 2333161 actcgtgcat tggtgcgatg cacgtcatcc aagatgctca tggcgagggc cgccccctcc 2333221 tgcggatctg tccctgcacc aagttcatcg aaaagcacaa ggctgttttc attgacctgt 2333281 tctaaaatgc cgacaatatt caccatatgg gatgagaacg tacttaaact ttgctcaatc 2333341 gactgttcat caccgatatc agcgaatacg tgctcaaata ctgccgcttc tgacccttca 2333401 tctgccggga tatgaagacc tgactgcgcc attaaggtta gcaggcctaa cgttttaagg 2333461 gtgactgttt tccccccggt gtttggccct gtgatgacaa tggttgaaaa atcgcggcca 2333521 agctcgatgt cattggcaac aacctgatca ggcggaagca atggatggcg ggcttttttc 2333581 aaacggataa agccggtgtc gttcataatc ggttttgtcg ctttaaccgc ttttgcatat 2333641 ctagcttttg caaaaataaa gtcaagcgtc tgcagcactt gcaaatctag aaatagctcc 2333701 tctgtatact ctgccgtttt ctctgtcagc acacgcaaaa tccgttcaat ttcttgcttt 2333761 tctttcactt tcgcctgctg aagggaattg ttcatatcta caatcgcctg cggttcaatg 2333821 aatagtgtcg caccagagga tgaggtgtcg tgcacaattc ctccatagct ggatctgtac 2333881 tcctgtttga ccgggatcac aaagcggtca ttccgaatcg taacaatcgt atcagacagc 2333941 attttcgatg cggaagagga acgcagcatc gactctaacc ggtctctgac tcttgattcg 2334001 agtgttctga gctgtgtgcg gattcctctt aatgtttccg atgcatgatc aagcacttct 2334061 ccgtgatcat caatgcagga attaatgtcc cgctctaaat cggacagcgt gataagctgt 2334121 tcagcatgct gatggatcag cggaatgtcg acaccgtctt cagccatttg cgtgataaaa 2334181 tgtttcattt gtttaactgc ataaagcagg cctgagattt cagtgaattc agaaggactg 2334241 agaacgctgc cgatttccgc ccgtcttaac gctcctctga tatctacaag gccgccaaat 2334301 ggcgcttggc ctctcagccg gataatgtca gaagcttcgt ctacttcatc cagctgtttt 2334361 ttgatttcgt ctatagaagc agaaggctta agctcgagaa gcatttcttt tccgagcgat 2334421 gaagcggcat gcccaataac ctgttctttc actttatgaa attcaagagc tgataatact 2334481 ttttgctgca cgattgtgtg agcctcctta cttaatcgtt gcgcttcaga aatgcctcta 2334541 cgtctttaag cgaccgggca ttcagaacgt ttttcgtttc cgtccatcct ttgcgcgcgg 2334601 cagtaacgcc agttttcata tcgtctaaca tctcaatatt atgggcatca gtattaatca 2334661 ccaatgtaac cccttgttcg tttgctttca ttaaatgctc tgtgcgcaga tcaaggcgcg 2334721 cagggttggc attgagttca agcgccgtat ttgttttcct cgcaagctca atcagctgat 2334781 caatatcgat ttcgtaaccg gcccgtctgc cgataaggcg cccggtcggg tgtgcgataa 2334841 tgtcaacatg cttgtttgtc agtgccgtct caagccgttt cataatcacg tgttccggct 2334901 gattaaaact ggaatgaatc gatgcaataa cgatatccat ttccgcaagc acatcgtcat 2334961 cataatcgag cgtaccgtca ggcaggatat ccatctcaac gcctttcaaa atacggaagt 2335021 tttcaaactc tgcattcagc gcgtcaattt cttttgcctg ctgcttaagt ctttctgcag 2335081 taagcccgtt ggcgaccttt aaatattgtg agtgatcggt gatcgccatg tattgatagc 2335141 cttttttgat gcaggcttca gccatctctc tgatcgaaaa tgcgccatcg ctccacgttg 2335201 agtgcatgtg gagatcacct ttgatttgcc cgagctctat cagttcaatg ctgtcgctgt 2335261 aggtttccac ttcctgtccg ctttcacgaa tttccggcgg aatcagcggc aggccgaagt 2335321 gcgcataaaa ttcacgttca ctcggaaatg ttttgatctc tccggtttca actgtctcaa 2335381 cgccgtattc actgatccgc tcgccgcgtt ctttggcgat ttggcgcatc ttaatattgt 2335441 gatcctttga tcccgtaaaa tgatggagtg ttgtcggaaa ctgctcttcc gtcacaagac 2335501 ggaaatcgac gcttgtttca tattcaaagg aaaggatgac ggacaccttc gtatctccgc 2335561 ttgcgatcac gcttttgatg tttggcagct caagaagctg ctctcttact tcagccggat 2335621 gatctgtagc aatgatataa tccagatcct tcaccgtttc ccgcgctctg cggagacttc 2335681 cggcacgaga aaatttgatg atatgcgtaa attgagaaag atgctcctca atttcccgcg 2335741 cgatccggag ggcgtagccg atcgggaacc gttcaggctg ttttccggct tccccgagcg 2335801 cctgtaatat tttttcttcc gattttttgc cgaagcccgc aagaccctgg accttttgct 2335861 gctcacaggc ttccttcaga gattctgcat cgtgtacgcc gagctcttta tacagctttg 2335921 cgattttttt gccgccgagc cccggcagct tcaataaagg cacgagtcct tccggcactt 2335981 ctttctgaag cgattcgagc gtgcttgact ttccttcatc tatatactct ttaatgacgc 2336041 tgtacgttcc ttttccaatg ccggacagcg acatcatatc gtccatttct gataagcttc 2336101 ggtcgtcctg ttccagagct gccgccgctt ttcggaaggc ggatacttta aacgggttgt 2336161 cccctttgag ttccatatag actgcaatgg tttcaagcag ccggataata tcttttttat 2336221 gcatatcata acccccagac gttcacatat gtttccatca tacttgaaaa aaacttctcc 2336281 ggacaagaga agttttttta tgccccgtac tgtgtccaca gctcttgtaa aagccctgac 2336341 aagtacggtg tatggttaat gatcacattt gcgagagacg attgccccat catttgctgc 2336401 aacgcgtcta ccggcagaac ggatgcgaca tacagcagca caaatgtaaa taaatagact 2336461 tctagaaaac cgagaacggc tcccagcatc tggttgattt gtttaatcac cggaatgccg 2336521 gctacaatac tcaggaacga gccgatgatt ctcagtaaga ttttagcaat gataaataaa 2336581 acgataaacg caatcgcatt atagtacgct gcttccaaat tccccgtaaa aaaagaaaga 2336641 gccggctgtc ccgctgaaaa atcgggtgcg ggaatccaat gtaaatgcgg tgccacgttt 2336701 ttatagaata aagccgcaaa ggcaattgat aaaataaagc tcgtcaagcg gataaactgc 2336761 aggataaaac cgcgttttaa ccccagtaaa gtccccatca ggagcaagat taagatgatg 2336821 atatctagca tagttgttca atccttttct ttaagctgac gctccagttt ttcacatttc 2336881 tcttgtaatt tgacataatc gtgcaccaca tttaccgctg tcagcactgc aagtttattt 2336941 atatcaaggt atggattttt ttcattgatt tctctcattt tatcatcaac aattccggcg 2337001 acatacctca tatgggctct gctttcttca ccgacaatcg tgaagtgctg gccgtaaatg 2337061 tcaacggttg tttttgtttt tttgccgtca gacaacgttt ctcctccatt ccgcgagaat 2337121 cctagttctt atcataacac gtttattaaa tgaatggaaa gacgagcctc ccgctgttat 2337181 gatacactgg tatatacagc gaaaagtgta aaaaaaggag attattacgt gtcccattca 2337241 gtgataaaag tatcgttgtc tgctattgac caaatgaaaa tgacgtacag cggttcactt 2337301 acagcctctg ttccgcaggg agccgttttt caggcaaaac cgcccggctg taccattaca 2337361 gcatatcaat caggtaaggt cttgtttcaa ggaaaaaacg ctgcggcaga atccgcgcgc 2337421 tggggaacag cagagcctca ggaaaagaag aaaacggcca aaaagccggc tgatccccgc 2337481 tatgcccctc cggcagatat cgccggaatg tctgttatcg gttctgacga agtcggaacc 2337541 ggagattact ttggcccaat gacggttgta tgcgcgtacg tcgacaaaac catgcttcct 2337601 ttaatgaagg aactcggtgt taaggattct aaagatttaa aagatccgca aatcatcgag 2337661 attgcccgaa acctgattaa aaccattccg tacagcctgc tggtgttaaa gaatgaaaag 2337721 tataacagca tgcaggaaaa aggcatgagc caagggaaaa tgaaagcttt gctgcacaat 2337781 caggcgatca cacatttatt aagaaaattg gatggagtaa agcctgaagc cattttgatt 2337841 gaccaattcg ctgagccagg cgtctacttc aatcatttaa agggcagaga cattgtgaag 2337901 gagcggacct attttagcac aaaagctgaa ggtattcacc tggctgtcgc cgctgcttca 2337961 atcattgcaa gatattcatt tttaatggaa atggataaac tatcacgcgc ggcaggaatg 2338021 acgcttccaa aaggggccgg tccgcacgtc gatgaagcgg ccgccaagct gatcctcaaa 2338081 aaaggggcat ctgcactcag aacctttaca aaactccatt tcgccaatac gcaaaaagcg 2338141 cagcgccttg ctgataaaaa acgttcatag aaaaaagctt gcagatttct ctgcaagctt 2338201 ttttatcagc ctcttaaaac agcttgatat gtgtcttcta acgctttcag cactttgctg 2338261 tgcgcctttg tcacttcttc ttcagtcagt gtttgttcag gattgacata ctggagtgag 2338321 aaagcgactg acttcttgcc ttcctccata tgctctcctt cgtatacgtc aaatacggtt 2338381 acctctttca gaagcttgcc cccggcctct ttaatgacgc tctcgagctg tccgcttgtg 2338441 acggttttat ctgttacaag agcgatatca cgtgtcacag acggatattt tggaatcgcc 2338501 gtgtaaacaa gcggtgctgt ttctgctgcg agcaacgcat gaagatcgag ctcaaatacg 2338561 tatgtttcct ttatatccag ttctttttcc aatgaaggat ggacttggcc gatgaagccg 2338621 atcagagaac cattcaataa aatgttcgct gttctgcccg gatgcagctg tttgcgttca 2338681 gactgtacaa attcaatgct gtctaggacg ttgagtttgt ctaacagccc ttccacaatt 2338741 cctttgacaa caaagaaatc aactggtttc ttttcaccct gccatagctg cttgcgccat 2338801 aatccggtaa cagctcctgc tacgcgttct gtttcaacag gttttgtgtc ctcttccttc 2338861 gttaggaaaa cggagccaac ttcgtacagt gcaactgagt cagtctgcct cgcaagattg 2338921 taagaaacag aatcaagcag atttggaaca agactgtgtc tgagaatgct tctttcttca 2338981 ctcattggaa gcgcaagcac agtattcagt gatttttcaa tcgcaaacgc tgtcgctttc 2339041 ttctcgtttg tcagtgagta agtgatggct tgtgataagc ctgcgccttc aaggaagcgt 2339101 ctgactttac ggcgttttgc ctgatatggc gttaatccgc ctgtagttcc cgctgtctca 2339161 ggaagcgtag acggaatgtt atcgtagccg tacagtcttg ccgcttcttc gattaaatcc 2339221 tcttctattg taatgtcacc gcgccgtgat gggacagtca caacgagaag atcatccgct 2339281 tcaccgaccg taaaaccgag acgtttataa atgctgatca gttcttcttt actgatcgtc 2339341 aggcctagaa cgctgctcac tttgtcagca gatacgtgaa tgttatttgc ttcgattgtc 2339401 aggtgatctt cctcaaccgt tccagcaagc acctcaccgc cggcatacag atggatcagc 2339461 tgcgcagccc gttctgctgc aagacgtacg cgtgccggat caattccttt ttcaaatctt 2339521 acgcttgatt cacttctcaa accaaggtct ttggaagcct tgcgaacctt ctgcccgttg 2339581 aaatacgcag cctcaagcaa aatggttttc gtatcttcct gaacctctga ctctgctcct 2339641 cccatgacac cggcaacggc ctgcgctttc gttccgtttg taatgacaag gtgatcggca 2339701 gacagcttac gttcttgatc atcaagtgtt acgatcattt cattctcagc tgcttttctt 2339761 actacgactt ccttagagcc aaatctgtca taatcaaacg catgaagcgg ctgtccgtat 2339821 tccaacagga caaaatttgt gatgtcaacg acgttgttgt gcggacgaat gcctgcattc 2339881 atcagctttg tctgcatcca aagcggtgac ggagcaatcg tgacattttt aatgattttt 2339941 gcagtgtaca gcgggttcgc ttcttgatct tcaattttga ctgaaatgta atcagacgct 2340001 tgttctgaag cagccgggta atccgtttgc ggaagcttta cctcagtgtc taaaatcgcc 2340061 gcaacctcgt aagcaacacc aagcatgttc atggcatccg cgcggtttgg cgttaaaccc 2340121 agctcaagaa tcgcatcgtc aagctgtaaa gccgctaagg catcgcttcc tgtttcagcg 2340181 tcattcggga atacgaaaat gccttctgca tactccttcg ccacaagttt gctttcgata 2340241 ccaagctcct gtaaggaaca gatcatgccg tttgattctt caccgcgaag cttggctttt 2340301 ttgattttga aattgcccgg cagcaccgct ccgactgttg caactgcgac tttttgtccc 2340361 ttatccacat tcggcgcgcc gcaaatgatt tgtacagggg cttcagctcc gatatccaca 2340421 aggcacttat tcagcttatc agcattcggg tgctgctcgc gctccagcac atggccgatg 2340481 acaacgcctt tgatgccttc tcctttgtat tcaattcctt caacctcaat accggctctt 2340541 gtaatttttt cagcaagaac agccgggtcc atgcctttta aatcaacata atcctctaac 2340601 catttataag aaacaaacat ccttgcatcc tcctcttacg cctgtttaaa ctgcgaaata 2340661 aatctgacat cgtttgtata gaagtggcgg atatcatcaa tgccatattt cagcatcgcg 2340721 atgcgctcaa cacccattcc gaatgcgaag ccctgatatt ccttcggatc aaagccagcc 2340781 attttaagca cgttcgggtg aaccattccg gcaccgagga tttcaatcca gcctgttcct 2340841 ttacatactg agcagccgtt cccaccgcat ttaaagcatg tcacatccac ttctactgaa 2340901 ggctcagtaa acgggaagaa gcttgggcgg agtctgattt cacggtcttg cccgaacatt 2340961 tttttcgcaa caagttcaag cgttcctttt aaatcactca tgctgatgtt tttgtcaacg 2341021 acaagccctt caatttgcat aaattggtga gagtgcgtcg catcatcgtt atcacggcga 2341081 tatactttac ccgggcaaat gattttaacg ggacctttgc cttcatgctt ttccatcgta 2341141 cgtgtttgga caggagaagt ttgcgttctc atcaaagttt cctctgtgat gtaaaagctg 2341201 tcctgcatat cgcgcgctgg gtgttctttc ggaagattga gcgattcgaa gttgtagtaa 2341261 tccgtttcaa cctctggccc ttcctcgact gtgtagccca taccgataaa taaatcttca 2341321 atttcttcaa tgacaacagt gagcggatgg cggccgccga ctgcaacagg gttccccggc 2341381 agcgtgacgt caattgtctg tcctgcaagc ttctgtttca tttcctcttc ttcaagcttc 2341441 tcgtttttgt cagcaatcgc attggcaata cgctccctta cttcgttcgc gagcgccccc 2341501 atttttggac gttcctcagc agaaagcttg cccattccgc gcagcacttc tgtaatcggc 2341561 cctttttttc cgagatattg cacccgaata tcattgacaa ccttcaatga gcttgccgct 2341621 tctacttgtt ctaaagcttc ttgttccagc tgttttagct tttcttccat tttgcatcct 2341681 ccttttatgt aaacaaaccg tcatatgtct ttggaaaata aaaaaaaccc gtcccttgta 2341741 caagggacga gttgtggccg cggtaccacc cttatttcag acagactgat gctgtcgtca 2341801 gcttcattga cataacggaa tcagattccg gttcaccttt acgcgcagtg tacgcggtcc 2341861 cggcgacaac tcaagaggtg aagccaattt ccggctgcgt taaaaatgct ctcagtcagc 2341921 ggcattttct ccctggaaag cagttgatca gaaattgagg tcctctgtca cggtttttga 2341981 aatattatgt tctattatag agaaatccaa cgcttggcgc aacactatcc tcgcaagtga 2342041 tacacgagga tggcagccgc aaccgcaacg tttagtgatt cagcctgtcc gtaaagcggc 2342101 acgtacaggt tcaaatccgt tttttccagc aatgcagcat ctacccctgc accttcattt 2342161 cctacaatga gcgcaaagga ttcagactga ggaatctcct ggtaaggcgc tccgttttgc 2342221 agcgccgtgc cgtatacttt tacgccctct gccttcaatt cgtccacata tgaaggcagg 2342281 tttcttctca caacaggaat atggaagtga gatccttgag cagatcgcag tgtttttccg 2342341 ttaaaggcgt ccgccgtgcc gtcaccgagt acaaccgcat ccaaaccggc cgcatcagcc 2342401 gttcgaatca ttgtgccaag gtttcccgga tcttgaacag cgtcaatcag cagcaccttg 2342461 cgtgccgttg ccagcttttc ttcaggcata tggcacacag cggcaatctg ctgcggcgtt 2342521 tcggtttcag tcacagctga aaacgcatct tcactcagca tatagcactg gataccagtc 2342581 tcaagatctg aaggaatcct cgtttcatcc tttacaagga tttctttcac aatgcccggg 2342641 cttttcaacg cctcttcaac gaggtgttct ccctctatca gaaatgtatt tgtttttgtt 2342701 cgttcttttt ttgtgtgaag ctttttccaa tccttcactt tttggttttt tgccgattct 2342761 atttgtttca ctgtctatgt ggcgctcctt tttttaacat gatgttatta tatcgcaaga 2342821 acagcacata ataaaccagg tgcagggtta gaatatacgt attacatttt agaaaaagga 2342881 gcgttttaca tggatcttaa tttacgtcat gccgtcattg ccaatgtcac cggcaataat 2342941 caggagcagc ttgagcatac aatcgtagat gcgattcaaa gcggtgaaga aaaaatgctt 2343001 ccagggctcg gcgttttatt cgaagtcatt tggcagcacg catccgaaag tgagaaaaac 2343061 gaaatgctga aaacgcttga aggcggatta aaacccgccg aataagacat gaaaccgggt 2343121 gacagcgccc ggtttttttc ttatataata aaaacatgat gagggggaac gccatgtttt 2343181 tacagccgtt attagcgaaa aaaattattg ctgaagttaa aaaaatgtac gaacgtgaag 2343241 tcattattgt aaacacggac ggtcttatta tggcaggcac aaacgatgag cgtgtcggac 2343301 aatttcatga gggagcgctt atctgcgcaa aagaaagacg cagcgtgatt attacaaaag 2343361 aagatgaaac aaggttaaaa ggagtgaaag caggcataaa cctccctgta ttttttgacc 2343421 atgatgtgat tgccgtcttc gggctgacag gtgagcctgc agagattcag ccattcggag 2343481 aactgcttcg aaaaatgaca gaactgttca ttaaggaatc gcggcactta gagcaatccc 2343541 agtggcgtga gagaatgctg gagtccttta tgatcgattg gctgcaatta aaggagtggt 2343601 ctcccagttt tcttgagaaa gctcagcttc ttggtgttga cctttcttcc cggcgccaaa 2343661 tgattcttat tcaggggtat gagtggtcac ctcatgatat tgaacaaatg gcacgcagct 2343721 ggaaatcctc gtaccctgcg gatttgttca tcaggtgggg aaatgaacgg attttgatta 2343781 atcatgaagt gccgcagcat gaacaaaggg atcggctttt gcggaaaatc cttcacattt 2343841 gttcgtttgc caataccgca agcagccaat atacagcagc tggcgccgga agggctgtcg 2343901 caagctccag cctgacagat tcatacgagc aagcggaaaa agcgctggct gtcagcctta 2343961 agcgaaaaac gcccatattt gaagaggatc tgaagcttga tatgtgtctg acggagatca 2344021 gcccgggaac ccgaaacgaa tttccgcaaa gagtattagg aaaggcgcta gagcatcagg 2344081 aacttatgaa tacgatacgg actttctttc atcacgattt gtctttgaaa caaaccgctg 2344141 aagacatgca tatacacatc aatacattgc gttatcgtct ggctaaggct gaacagctga 2344201 cgggattacg ttttgaccgt accgaggacg tcgtcacgat gtacgtcgca ctctattttt 2344261 tagatcaaga tacaaaatag agagagtttc agtttcattt tttgtatgtt tctccatgga 2344321 aggctttgct ttttttcttt tacaatagat tgaaagcgtt ttttgacagg gggatgggtg 2344381 aaatgatcac caaggatgta aaggagcagc tgattcaggt ctccggacca gaaaactttg 2344441 atgactcgaa tgccggccgt ctcgtctatt catatgatgc gacgcctcag tatcagtcta 2344501 tgcctgatgc cgtgattgct ccgaggaata ctgatgaaat atcacgcatt ttaacaattt 2344561 gcagcgaaca tcgagtgccg atcgttccaa gaggatcagg gacaaacctg tgcggcggca 2344621 cgtgcccgac tgaaggcgga cttgtgcttc tctttaagca catgaaccag attcttgaaa 2344681 ttgatgaaga aaatttaact gccacagttc agccgggcgt cattacgttg gatatgatcc 2344741 gggcagttga aagcaaaggt ttattttatc cgcctgaccc gagttctatg aaaatatcaa 2344801 ctatcggggg caacatcaat gaaaattccg gcgggctacg cggattaaaa tacggtgtca 2344861 cccgcgacta tgttattgga ctggaggttg ttctcgcaaa tggtgacatc atccgcaccg 2344921 gcggaaaact cgcaaaggat gtggccggat acgatctcac acgtcttttt gtcggctcag 2344981 aaggaacact cggcattgtg acagaggcaa tcgtcaaact cgttccaaag ccggaaacaa 2345041 agaagacgct gcttgccctt tatgaaaaca tcgatgccgc tgctcaaacg gtatcggaca 2345101 ttattgccgc aaaaattata cccgctacgc ttgaatttct cgatcagcct acactattgg 2345161 tgattgagga ttatgccaaa atcggacttc cgacaagcgc aaaagcagtt ctgttaattg 2345221 aacaagacgg gccatttgaa actgttgaac gggatatgga aaagattgag gcgatctgca 2345281 aaaaaggcga cgccgtatcc gttcagaccg cacaaacaga ggaggaagcg tttgccctga 2345341 ctgaagcccg gcgttctgca ctttctgccc tagcccgcct caaaccgacg acgattttag 2345401 aggatgcgac cgttcctcgc tcagaaatcg ccaatatggt taaagcgatt aatgatattg 2345461 ctgctaaata tgatatttcc atctgcacct ttggtcatgc gggagacggg aaccttcacc 2345521 cgacatgcac gacagacata agaaataagg atgaaatgga acgtgtcgaa caggcttttg 2345581 ccgagatttt tgagaaagcg attgaacttg gcgggacgat aaccggagag cacggagtcg 2345641 gggaaatgaa agcgccttac ttggaaatga agctgaaaaa agaaggcatt gatgcgatga 2345701 aagcgttgaa agcggcattt gacccccgga acatattaaa tcccggcaaa atgtttgcga 2345761 aagatgccag aaaacgtgtg gtggcggaaa gatgacaaca gaaaaagaaa tgaaacagat 2345821 ccaaaatgaa tttaaagagc gtatggatga aggagagtta ttaaattgta tgcgctgcgg 2345881 cttctgtctt ccttcctgtc cgacctatat cgaatcggga tttcaggaaa cacactctcc 2345941 gcgtgggcgc atcgccttaa tgaaagccgt agccgacggt atgattgaac cggatgaaga 2346001 tgtcgaacgg tcgctgtcac tttgcctcgg ctgccgcgcc tgtgagcctg tatgcccgtc 2346061 tggcgtgaaa tacgggcagc tgcttgagga agccagagat attatccacc aaaataaaaa 2346121 acactctctt ggtgaacgtg tcatgcgaaa gacggctttt cacgagctgt ttccgcatca 2346181 aaaccgcatg cgctcagctg taagccttat cggtttgtat cagcgttcag gactgcaaac 2346241 cgctgtgcga aaatcaggca tgcttcgggt cctgcctgag catttgcgga cgatggaagc 2346301 tgttcttcct gatgttccaa aaagcaaaga catgaaacat cggccgcgtt tcctgccttc 2346361 cattggcccc atgaaaaaac gggtcgcctt tttttcgggc tgcttaatgg atacaatgtt 2346421 tttaccgacc aataacgcca cattgaagct tttacagctg gcaggctgcg acattgtcat 2346481 tccgcctgaa caggcttgct gcggggcgct tcatggacac agcggtgaaa aaaacacagg 2346541 gaaagagctc gcgaaacaaa atatcgctgc tttcgaagca ttagacgtgg atgcagtcat 2346601 tacaaacgca ggaggatgcg gagcctttct cactgaatat gatcatttgc tgaaggatga 2346661 ccctgagtgg tcggaacggg ctgccgcttt tgttcaaaag ctgaaggatt tttcttctgt 2346721 tttggttgaa ctcgatttcc atcaaatgga tctagcactc gagacgcctc aggtcgttac 2346781 ctaccaagat tcatgtcatc taagaaatgt gatgcatacg tcacttgagc cccgccagct 2346841 tcttaaaagc atcaaagggg cggaattcaa agaaatggag aaagcagaca gctgctgcgg 2346901 gtcagcggga atttacaaca tcgtcgaagt tgaaatgtct atgaaaatac tggacagcaa 2346961 aatggctgcc gtcaaagcaa ccgaagcgat cctcattgta acagcaaatc ctggctgcct 2347021 gctgcagatg aagctcggca ttgaacgcga aggactaagc ggtaaagtca gagccgttca 2347081 cctggctgat ttgctattag aagcagccgg gcacaaaaca tcatgagaaa gcccaaaaca 2347141 gacattgttt tgggcttttg tgcgttattc catcggactg caaatttcga tataatgtcc 2347201 atccggatca gcgatatagg cgaccgtctg cccccatggt ttcactttcg gctccccgat 2347261 aatcgatacg ccttgttctc tcatcctttt gatgaccgct tctacatttt cagtaacaaa 2347321 cccgatttca aatgtgtttg aagcagatgt atccggaatg tccagcgccg tgatgtctct 2347381 ggcgctttcc cgggtattaa gcgccaatat cgtagaccct gtatcaaatt cgacatacgt 2347441 gccgtgttca gcacgaatcg gcagtcctaa aatatcccgg taaaaaatga atagcccgct 2347501 tgctgtccga tacgtataga ataagatatt tcattgatag attcattgcc aacccctctc 2347561 agcattttca atagtccttc tagcccggta tagatgcttc catccttaag ctcggatctt 2347621 tccacatctg cgcccatttt ttcacagccg ccacgataat gatgaagcct aacaccagca 2347681 tgatgataga taatacgcca ttcaatacac tatatcctgc tgcttcagga ttgagataca 2347741 cattgcgcac catccaatag cccgcataat tgacagtgac atataaatag gcaagcggga 2347801 taaggcaagt cagaatgtac cggcgtttat cggcgatttt cagcacgatc gtcgctccga 2347861 taatcagccc cactgaagcc atcagctgat tagaaacgcc gaagagcgcc caaatggaac 2347921 cgatatctcc tgaatacagc aagtaccccc acatcaaaca ggcaagcgcg ctggcaaata 2347981 cagagcccgg aatccagtct gttttcttca gcggcttata cacctccccg aagaagtcct 2348041 ggatcaaata acgggcgaca cgtgtgccgg cgtcaatcgc tgttaaaata aagaccgctt 2348101 caaacataat gacaaattgg aaaaagtatg aggccaaatg gctgaaaaac ggcattccgg 2348161 taaaaatata agtcatccct accgcaagcg tgacggctcc ccctgttctt ccttctaagt 2348221 ccaaaccgat ttccccgctc aattcaggca aatgtacgac attcatgcca agcgtacgga 2348281 aaacctcagg cgtgctgtta atcgcaaagt aatcagcagg ctgtaaagcg gtcgctgcaa 2348341 tcagcgccat gataccgaca agacactcaa caagcattgc gccaaacgca accggcttca 2348401 tatcactcca tttattcagc attttcggtg tcgttcctga gccgacaaag gcatggaacc 2348461 cagagatcgc cccgcaggcg atggttattg agatgaacgg ccagacaggt cctgccagca 2348521 ccggccctcc gccttttacg aattctgtaa acgcagggaa cggaatggac ggattgacga 2348581 caaacacacc aacaatcaaa gcgataaaaa caccgatttt cataaagctg cttaaataat 2348641 cacgcggagc cagaagcagc caaacgggaa gcgcagccgc aaaaaacgca taaacaggaa 2348701 gcgcgattgc aagcgttttc gtatctagcg ttaaaaagtc accgagcgcg gtagtctgta 2348761 cccatggacc gataaagact cctgccatta aaaagagaaa gccgaccgtt gaagcgagct 2348821 ttaaatttcc cgttttctta taaaataagc ccacacccat cgcaatcgga atcgtaatcc 2348881 ccaccgcaaa tgttccccat ggattacgtt caagcgcatg caagacaacc atcgacaggc 2348941 ccgccattgt gatcgtgatg ataaacagca tggacagtcc tgtacaaaat cctgcaacag 2349001 ggccaagctc atccttcgcc acttccgaca gcgattttcc gtttttgcgc atcgatgcaa 2349061 acaacaccac aatatcatgg acggctcccc caattaccgc cccgattaac agccacaata 2349121 atcccggcaa atagccaaac tgcgccgcca gaattggtcc gaccagcggc ccggccgctg 2349181 cgatcgcggc aaagtggtgg ccgaacgaaa cccatttatt tgtaggcaca tagtctttcc 2349241 catcctcaag cgcatgagca ggtgttggct tgtcatcatt cactttgaga accttcacca 2349301 tcataaatgt tccgtataaa cgataggcaa tagccaaaat acacattgat gctatcacaa 2349361 ttgtaaccgc attcattttc tcccatcccc ttttctgttt ttcataaata tatcataatt 2349421 tcatggtgaa aagcggtcat tttttcctat acaaaaagcc ggctggaatg ggccggctcg 2349481 tggcagttga aagacaagcc ggagagaaat ctccggcttt gctattctta tgactgtttt 2349541 ttcaggcgga tcacattcca ggaaagcggc gtgaaatgag cagttaagcc gttttcgctg 2349601 acagacgatg atccgttgga atgcggaacg acattttttc tgttatgctg gtttgttgct 2349661 ttgatatcct gatgctcaag tacgatgtgc tctgcgattt ggtaggattc aaagcctctg 2349721 agcgaaatct ccgtctccat ctgatcctca gccttgttta ccgcaaaaat agtgagtgtt 2349781 tcttcctctt cagagtacac aacagcagca tcaacatatg gcacatcagt gaaatcagaa 2349841 caatcgtact taggagaaga aataagcggt ttcagtgact cgccccttcc gtaaacagaa 2349901 gcatgcatgt atggatagaa aatcggctgt ctccatgctt ctccgccttt ttccgtcatg 2349961 atcggcgcga tgacattaac aagctgtgca agacacgcaa ttttcacacg gtctgcgtgc 2350021 tgcagcatcg taatgagcag agagccgact aataaggcat cttcaaaatt gtaaatatcc 2350081 tctaaaatcg gacgcgcagt gatccacggc tcgacttttt tatcagcctc atttgagtgg 2350141 taccagacgt tccattcatc cagagagaga ttgatagttt tcttgctgcg tgtttttgct 2350201 tttacatagt cacaggtcgc agcgactgat ttgataaaat gatccaaatc catagaacgt 2350261 gccaagtagt ttggcagatt gttatcccgg tttccgtagt aagtgtgaag agagatatag 2350321 tcgacatgct catacgtatg ctcaagcacc ttcgcttccc aatcgataaa ggtcggcata 2350381 ccgctgtttg agctgccgca ggcaacgagt tcaattgatg ggtcaaccca cttcatgacc 2350441 tttgctgtct ctgcggcaag ccgtccgtat tcatcagctg ttttgtggcc gatctgccat 2350501 ggtccatcca tttcgtttcc taagcaccat gttttgatgc catacggctg ttcatagcca 2350561 tgcgatcttc ttaaatcact ccagtaagag cctttcggat ggttgcaata ttcaacgaga 2350621 ttacgggcgg catctatgcc tcttgtgcca aggttgacgg ccatattgac ctcagtgttc 2350681 accttttttg cccaagataa aaattcattt gttcccactt cattggtttc tgtcgtttgc 2350741 catgccaagt caagccgtct cgggcggttt tcgactggtc cgacaccgtc ctcccagttg 2350801 tatccggata aaaagtttcc gcccggatag cggatgatgg gaacctgtaa ttctttgatc 2350861 agcgactgga catcttttct aaatccatct tcatccgctt cagggtgatc aggctcgtat 2350921 atgccttcat ataccgcacg acccatatgt tcgataaacg agccataaat ccgtttatct 2350981 acttcaccga ttttatattc tttgtctaca atcattcgcg cttttttcat cacacgtttc 2351041 ctccttcatt aacctttgac tccccctacc gtcaggccgg agataaagta cttttggaaa 2351101 aacaagaaaa tgataatcac cggcaaaatc gcaaatactg agccggatat aagcatgtcg 2351161 taattatttc cataagggct cagcaagctg gacagcccta ttggaagcgt aaacatttct 2351221 ttcgaccgaa gcacaatcag cggccacaag aagttgttcc agctgtttaa ggactgaagg 2351281 ataatcatcg caccgaaagc cggtttcatc agcggtgcca taatcctgaa aaagatgccg 2351341 aattccgtac agccgtccat ccttgcagag tccagcagat ctcttggaag gccaagagca 2351401 tattgcctga aaaagaaaac agcaacaggt gaaacgataa acggcaatat gacacccgta 2351461 tatgaatcga tcaagtgcag tccgacagta agtttaaaca gaggaagcat catcacttcc 2351521 agcggaacca tcataataat cagcacaaga acaaagatga tatttctgcc cttaaaatca 2351581 taaaccgcaa gcccgtaccc gatcatcgaa gaaaaaaaca gagtgagcac agtcgtaaaa 2351641 agtccgagta caagactgtt aaaaaaccat ttgaaataaa tgctgccgcc attaaacaga 2351701 aatgtgtagt tatcaaaact catcactttt ggatcaatat caagattcag ccccacacgc 2351761 aaaagctcag atgacggctt taatgatcct aaaagcaaac agaaaatcgg aaaaagatac 2351821 aataggctca gcatcataaa aaacagggtc agcgcaattc tataaacgct aaactgagga 2351881 ctgtgccgca acatttatcc ctccccctta aacgagcctg acagctttaa tgaaatcagg 2351941 ctgacaacaa ggatcacaat caaaagcaca atgccgatgg ccgctccgta tcccatttca 2352001 ttgtaggcaa gtccctgctg atacaaatat ccgacaagcg tcagaccaat attacccggg 2352061 gaattattct gccaaaggac gtagctttcc tcaaacatcc tgaagccgcc gatgatgctg 2352121 atggtcagca catatacggt tacaggcttg agaaacggca gcgtgatgtg cagaaatttt 2352181 ttcattgtat tcgcgccgtc tatatcagcg gcttcgtaca gctctttcgg cacattttgc 2352241 aaacctgcta aaaagtaaag gatgttgatt cccatccatc tccatgaagc aagcagcacc 2352301 atcaaaaaca tgccggtatg ttcattgttc atccagttct gaggtgaaaa gccgagttta 2352361 agtaggatgg aattggccag agacgtttcc atttctccga agatcagccg aaaaatgatc 2352421 cccgcgacaa tggttgaggt caatgccggg ataaataatg ctgatttaaa tatatttcta 2352481 aatttgacca gctttgaatt caggaatatg gccagaagca atggaacagg aatcagcacg 2352541 atcagcgtcc aaaaggtgta ttccagcgta ttccaaaggg cggtatagaa cgtcgggttg 2352601 tttagcgctg tataattaga caatccgaca aaggacacct ctcccggcaa aattctttgg 2352661 aagctcatga tgaagacact aatgatgggg tatagaaaaa atacgagaaa ggataaaacg 2352721 aatggcgctg taaacagata gggcgccgct ttttttgaat aaaacagatc tcgccagcct 2352781 gattgtttcg cagctgaagg aacgggatga accgttcccg ttttcacagg tttcatgaga 2352841 acctccccgc tttcactttt tgaatgggat tctatttctg tttcagttca cctgccgctc 2352901 tgtccaaggc ttgtttaggc gttttttgct gagatttaag cgcgtcgaac aatacgcttc 2352961 tgttgacaag gtctgaagcc ttggcaaaat cctcatgtaa ataaattgga ttgatttcat 2353021 ccttgatatc gagcagcaca gaaaaaatgc ctgttccgtt ttggaagtaa tccgtgtatt 2353081 tgtttttctc tttcaattcc ttggagctcc aaacatccca gcgaagcggg tcaaagccga 2353141 gtacgctcca gagtttttta tttccttctt cagagccctt cgcaaaggcc aaaaactctt 2353201 ttgctaactc aacatgcttg gattgcttcg gtacaacagt tgccgtaccg cccaaacctg 2353261 ccgagcggtc gcccccctct ttccatgccg ggagcggtct gatggcaatc ttccctttca 2353321 gatcaggcat ataatcgata aatcttccca tataccaaat cggcatgaga actgaagcag 2353381 ctcctccttg gttcataaag ccgtagtatt cttcactgtg atgcccgccg cccggcgcag 2353441 gaatcatcgt tttatcattg atcatgtctt ttaaatattg aagtgttttt acgttggtgt 2353501 cattattgag gatcagcttg ccgtttttat caaaatagcc tgagttttgc tgtgaaatca 2353561 tagataagaa cgttgcggaa tcatttgttt ccaccgttcc catcggcttc ccggtcactt 2353621 tgcgcacttt ctgtccggct ttatggtaat catcccatgt tttaatatcg tcaggattga 2353681 cgccggcttt tttcatcaca tccatgttat aaaacatgac cgttgtccct acatgtgtat 2353741 cgagtccgta aagctttccg tttttgctgt acaatgtcag ccgcgcctca acgaatttat 2353801 cgcgatcctt ttcaatcagc ggagtcaagt cggcaagcgg tatgtcagag cccttcaaaa 2353861 agtttgaaaa acgggccaat tcgacatctg caatatcagg aacgccttct cccgctatta 2353921 gggagataga taagttatcg tgcatttgtc catatggata aacgaccgta ttcagcttaa 2353981 ttttgcggtc aggatatttt ttgttccatt ccttcaccat ttccacatag aactgctcat 2354041 gaagcccgtt aaatgtccaa aaggtcagct cagtttcacc cgatttgccg gatgattttt 2354101 ctgctgaaca cccggcaatg actaatgtca gcaacatcat gagcacaaga aaacagacag 2354161 tcattttttt catctgcgtt accccttcca ttcgaggtgc gggctattca tatagaccat 2354221 ggttgatcag cgttttgttt tcattgatga ttcttaatcc ggtgcatcgg tctcttaagg 2354281 tgtgcgcgtg tctgaaggca tttttgacgg aatcctgccc gacaccgatt tcgtcaaaat 2354341 acgcagggcc tccggctgat ctcagccaat cagccagcac ttctcctctc gggagtgttt 2354401 gataagccga ttggatggct tcccggcggc ttggtgaaaa ttcgttcagc ccgtcatcct 2354461 gagcgagctt tctgtatgtg tcagttaata aaacagcggc acagcccacc tttgccccat 2354521 gaagaatctg aggccgtttt ttctccatta actccatttc aatccaatgt gaaatatgat 2354581 gctcgccgcc tgatgccggt cgggaatgat ctaatgccag catgacaagc cccgatacaa 2354641 gtaaagactc catcaaaacc cgtatgccag tttccgtttt catcgcaatg tcttctgtgt 2354701 gttcaatgca ggcagcaagc gcctcctgaa cgatcttagc tcctgcaggc gaataaggct 2354761 caccggcaag atgccgggat atttcccaat ctgctaaaga cgtgatttta ccgagcatgt 2354821 caccaaagcc agccgccacc attgactgcg gtgccgcttt taatagatcc agatcagcga 2354881 acagcgcaga tggggccttc gtttgaatgg ttgttttcgt gccgtataaa ataatcggcg 2354941 caccggctga tgtaaaaccg tctacagatg gagcagtcgg ataagaaata aacggcaaat 2355001 ctctttgaaa cgccgcaaag cggacgatat catgaatcgt gcccgaaccg actgcgatca 2355061 tgacatccgt tggttgtttc gtatggatca gcacatgaat gagcgatcgt tcatcagctg 2355121 tcacatctcc ggcttcattt tctggaatga tcaggcactc ggcctgaaat ccttcttgat 2355181 tcagtcggtt ttctaaatca attcctgcaa tgcggtgtgt attcgcgtcg cagacaagga 2355241 caatatgttg attgtttttt cgttttacat aatccaaaag cgaatcagct gcttgcttac 2355301 cgagaacaat ttcttcaact tttataggca acgtcttttc tccggcgttt tcaaaagcac 2355361 gctgaacgtc agctgcgata cgattcatat cagaatcccc tcctcagcca atttggttac 2355421 atccttaata gaatccagca cataatccgg cgtgtacaaa cgctgttcac cctgtttcgc 2355481 agaaccagtt agcactaagg cgcttttcat gccataaagc ttccccatcg caatgtcaga 2355541 ttcaatgctg tctcctataa tcatgcattc atgtgcggac agccccattg ctgtacaggc 2355601 agcctccgcc atcagccatg acggttttcc gacaacaagt tcagtcttcg cttgtgcaga 2355661 agtctcaatt gccccgatca ttccggccac atcaatggca tttccgtctt cgttcggaaa 2355721 agagcggtct ttgtttgtag cgataatacg agcgccgccg gcagccgctt gaaaggcttg 2355781 atttaaatcg tcgtacgtga gcgtttcatg aagggagatc acgagccaat ccgcttcctt 2355841 cggttcgctc gcgttctgca caccggccag cctcagctcg tcaaccaagc cttgctcccc 2355901 aagcacccat acctttgaaa aacgataatg ttttttcaga aaagccgctg tcacgcttga 2355961 tgacagaaca atgtcgttta cgtccgtttc aatccccgcg ccaagaagtt tttttctgca 2356021 catggcacgg gagatattcc cccggttgct taaaaagacg attttctttc ccattctcct 2356081 aagcgttttg atcgcttctc ttgctccttc gatcaactca tttcctctga atacagtacc 2356141 gtccaagtca atcagaatgc cagccggtga cacaggcgta tcatgactgg ccataatacg 2356201 catttgctcc gtgttttcga taaaaatgct tttcatgcag gactgtattg attggggtta 2356261 catccttgtt cagcataatg gagtgatagg ccatttcggc aaccgtttct aatacaactg 2356321 cgttatgaat ggcatttaag gcgtcagtgc cccagcagaa cggtccgtga ttattcacga 2356381 gcacacccgg cacctgttcg taattatgat gctgaaaggt ttccgctatg acttttcctg 2356441 tattcagttc gtagtcatga atgatttctt catcgtacat ttctcgagta catggaatcg 2356501 cactgtcaaa ataatcagca tgggtcgtgc ctaacggagg gatgtctctg cccgattgcg 2356561 cccagcttgt cgcccattga gaatgggtat ggacaattcc cccgatattc ggaaaggctt 2356621 tatatagata aacatgggta ggtgtatctg aagaaggttt aagcgagcct tcgacgacct 2356681 ctccatcaag gttcaaaaca accaagtcat cggctgtcag gtcgctgtat tcgactccgc 2356741 taggtttgat gacaattctt tctttttcac ggtcaatgcc gctgacattt ccccacgtaa 2356801 aggttaccag ctgatgctct tgaagcttca ggttggcagc cagcacttct ttttttaatg 2356861 tttcaagcat gctccatcac cctttatcaa ttctttttgg cggcagatga aaattgaaga 2356921 tttttgatcg ttttcagacg cttcatgaca tggttttctt ttccgaaata atgaaccagc 2356981 tctttatatt cagcgtacaa tttttcataa accgcggcgt tttcggcatt tggcgtataa 2357041 gttatatctt tcagttttcc catgttcgcc gctgcctttt tgatatcatc gtagccgcct 2357101 ttttctttgc ctgctgcaag cgcgccgaaa atggcagatc ctaaggctgg ggcttgcggt 2357161 gaaccagaga ttttaatgtc catgtttgtc acatccgcat aaatctgcat gacaaacggg 2357221 tttttctcag ctattccgcc ggctgcgaac agttcctcaa tcggaacacc gctttctttg 2357281 aatgtttcga taatcatccg ggttccgtaa gctgtcgctt caactaacgc tctataaatc 2357341 tcttcaggct tcgtcagcag tgtcatgcca agcagcatcc ctgttaaatc tgcatcaaca 2357401 agagttgaac ggtttccatt ccaccaatct aaagcaagca agccgctttc accaggcgct 2357461 tgatggtttg ctttctcact cagcagctca tgaacgccaa tgtttttttc ctttgcttcc 2357521 tcttgataag ctggcgggac acatgttttc acaaaccagt caaaatgatc gccgacacag 2357581 gactgcccgg cttcatatcc cgcatagccc gggagaattc cgttgtccac aacgccgcac 2357641 attcctggaa cgatatgcac ctcttcacca agtagaacat ggcacgtcga ggttcccata 2357701 atcatcagca ttttccctgg ctctgtaatg ccgaccgccg gtaccgaaac atgagcgtcc 2357761 acattggcaa ccgcaacagc cgttcccggg agaagccctg tcagctttgc cattttttca 2357821 gtcagactgc cggctttttc tcctactgaa tgaatagaac ctgacaattt gtcctttgta 2357881 atcgttttca ttgaaggatt taatttctca aagaaatcat ctgacggata ccccgctttt 2357941 tcactccaca tcgctttata ccctgcggta caattgcttc gcttgagcga gccgcacagc 2358001 tggtacacga tccagtccgc agcctcgatg atccggtcag ccgcttcata aatgtgaggc 2358061 gcttcctcgg caatttgcat gacctttgga atcatccatt ctgatgaaat ttttcctccg 2358121 taccgctgta aaaaagcctc tccttcttct tccgcgattt gattgagccg atcagcatgt 2358181 ttttgggccg catgatgctt ccagagcttc acatagctgt gcggctcctc ttcatattca 2358241 ggcagcatgc ataacggctg cccgctgctg tcaataggaa ggatcgtaca tgccgtgaaa 2358301 tcaattccaa tcccgataat gtctttcggg tcaacgcccg tctgttcgag taaagacgga 2358361 atggttgttt ccaagacttc gaggtaatca gcagggtgct gcagcgccca gtcacgcggc 2358421 agcttttgac ccgtttttgg aaggacggta tcaatgacag catgcctgta ttcttttaca 2358481 gcagccgcaa gttcctcccc tgtttggaca tgaacgagca ctgctcttcc tgataaagtt 2358541 ccaaaatcaa cccctattgt gtaagccatg tgacatcccc ctctactttt gaagccggta 2358601 aagcgcctcg ttccatttta actcgtgttt cagtttatga attgtcgtat cacgggaaat 2358661 gagaacactt tcgattcccg ccatttccgc ccaatcaagc atttgctccg ctgtcagttc 2358721 ataagacagg caggtatggt gtgcaccgcc ggctaaaatc catgcctccg ctgctgtttt 2358781 caatgacggc tccggcttcc agagaacacg ggcaaccggt aaattcggca tgtctttttc 2358841 aatttcctgg ccgttgactt cattcagcac aaggcggaaa cgcccgccaa tatcaacaat 2358901 gctagcttga atggcagaac cgctgatgcc gttaaatacc aaacgcgcag ggtcctcttt 2358961 gccgccaatc gaaagcgaat gaacctcgat tttcggctga tccaaagcga cagtcggaca 2359021 cacttcaagc atgtgagagc ccagaatcat ttcatttccc ggttcaaaat ggtacgtgta 2359081 atcttccatg aaggaagttc tttttccttt agccatgatt ttcatcatcc gtacaagggc 2359141 cgctgtcttc caatctcctt caccggcaaa cccatagcct ttctccatca ggcgctgaac 2359201 ggcaagtccc ggcagctgtt tcattccgtg cagcacttca aacgatgtcg taaacgctgt 2359261 gtatccgcct tgctcaagaa aagcggttaa tccaagttca attttcgcct gttctttaat 2359321 ggacgctacc tttgcttcgt cacgttttgt ttcctcactg atcacatata gtctgtcata 2359381 ctcggcataa agcgtgtcaa cctcgtcgtc cgtaatgcga tccatcactt caacgagatc 2359441 cccgatgcca tatccgtcaa cctgccagcc aaattgaata tgcgctccca ccttgtctcc 2359501 gtccgttacc gcgacatgac gcatgttatc tccaaatctg gcaaccttaa tatgtctgct 2359561 ttcatttaat gcagccgccg tatccatcca ctgggacatt tcttttttca cttcttcatc 2359621 atcccaatag ccggcaatga cttttcggct aagccccatt ctcgagttga tgtaaccgta 2359681 ctctcgatcg ccatgcgcgg attggttgct gttcataaaa tccatgtcaa tcgtacccca 2359741 cgggatatcg cgattatatt gggtatgcaa atgcataagc ggtttttgat aagaggaaag 2359801 gccttctatc cacatttttg caggggaaaa tgtgtgcatc catgtaatga tgccagcaca 2359861 tgtctcactg tactccgctt ctcttaacag ctctctaatg gtttccggtg aagtgacgac 2359921 gggcttatga gtgattttat atctggaaga aatcccgctg agcccctcac aaatgctttt 2359981 agcatgctga tctacgagtt ccagcgtctc ttccccgtat aggtgctggc ttcctgtcac 2360041 aaaccagaat tcataatcct ttgtctgaag catgtaaact gcccctttct cataaaataa 2360101 aacgctttca aatacaaaag atacgtacta atgatagaaa ataaacctat aaataaatat 2360161 ttgtacgaac aattttatta tagtaattga ctattatact gtcaatcttt tcttttaaaa 2360221 aaagccgggg gcagagcccg gctttttaat tcaataggac ggccagcccg agctccaatt 2360281 caaatcattg atgagaagct ttggaatgcc gttgtcattg gcatcatagg catggcgaac 2360341 aagaatgttt ccgttcacaa tatcctggcc tccaggtcct ttccattggt cattgcccga 2360401 atccaaaatg gtgcctccgc cttcaagcat gctttttccg cttttatcaa gataagggcc 2360461 tgtaatgctt ttggatcttc cgtaagcaat tttgtacgta ctgtttaccc cgtcacagca 2360521 tttatcaaat gaaaccatta aatagtaata tccattttga tacgtaagag taggagcttc 2360581 taaggcacct ccattattcg gtctagctgc aatcgaatag agcgagcctg taggcttcat 2360641 tgtactctta tcgagcttag tcagcttaat gccgctccaa aacgagccga atgcaagcca 2360701 cgggttgcca tccttatcga atgtcagctc cggatcaatg gcgttataat tatttgagct 2360761 tgtcgaacgg atcaccaagc cctcgtcctt ccagcccccc gaactgatgc ttgttgaaga 2360821 tgccaggcca atggcagatg tattgcttcc aaaagaagaa acggaataat atagccagta 2360881 cttgccgtta tagtattgga tgtccggcgc ccactggttt tggccataat tcggcacata 2360941 attggaccac cacgatagcg gtgtagtgaa aatggatttt tgtacggtcc aatttttagc 2361001 gtctgaagac ttcaaaaccc gcagtccccg ttcttcagta agccctgttc cgagcgcata 2361061 ccatgagctc ccctctttaa tcatagtcgg gtcatgaagc agctcattgg atgcacccca 2361121 aaacgctgcc tctgcgggag cagcagaagt gaatatcaaa cctgcagcca gagctgcact 2361181 cgaaaagtgt aagaagcgtt tccatgtttt tttctttttc aattttgttc aacctccttt 2361241 attttagaaa gcgcttacaa attagattat ttatcctccc ttcctgtcaa atcgactgcg 2361301 tatcgtatat cgtcatgttc aggaaatttt cggtatcccc tttattgtag tcactatgct 2361361 gtaatttgta cagacaaaaa aatagaatcc acctcaatag gcggattctt ccgtatcttt 2361421 attggtacgt aatttcgtca accgtttttc ggtctaactt cttaatgact tctgtaatta 2361481 actttaccgc gttttcataa tcatcacgat gcagcatggc cgcgtgcgta tgaatgtagc 2361541 gggttgcaat ggtaatggac agcgcaggaa cgccatttgc cgtcaaatgg atggcacccg 2361601 aatcagttcc gccgccggca atggcatcaa attggtacgg aatgccggct tcctccgcag 2361661 tggctacaac tgcatcgcgc aaacctttgt gagagaccat ggatgcatcg taaacgataa 2361721 tctgcgggcc tttgcccatt ttgctctgcg cttccttctc ggaaatgcca ggcgtgtctc 2361781 ctgctatccc tacatcaaca ccaaacgcaa tatcaggctg aatggtgtgt gcagccgttt 2361841 tcgctcccct cagcccgact tcctcctgca cggttccgac gccatacact atatttggat 2361901 gatctgtgtt ttgtaagttt cttaacacat caatagcaat cgcacagccg atgcggttgt 2361961 cccaggcctt tgcgagtagg aatttttcat tgttcatgac cgtaaattca aaatgcggaa 2362021 cgatcatatc tcccggaagt acaccccact ccaaggcttc ttcccggctt gaagctccaa 2362081 tatcaataaa catgtctttt atttccactg atttttttct tgcttcagga gacaaaatat 2362141 gaggcggctt agatccgata acccctgtga tttctccttt ttttgtgaca atggtgacgc 2362201 gctgagcaag cataacctga gcccaccagc cgccaacggt ttgaaaacgg ataaagcctt 2362261 tatctgtgat ttgtgtcacc ataaagccga cttcatccaa atgtccggcg atcataattt 2362321 tcgggccgtt ttctgcacca gttttttttg caattaaact gcccaggcga tctgttgtca 2362381 cctcatcagc aaatggttct atgtatgatt tcatcacttg ccttacttct ctttcattgc 2362441 ccggtatgcc ttttgcatct gttaaatctt tcagcatggt caatgtttca tctaattttg 2362501 ccatgttcca aaccctcctt catcagtcct gcattcttat tatacaaaac atggcgctaa 2362561 ccatacgact atttcacttg aaaatcgggt atatgttttt acagctttct tttagaaaaa 2362621 gtgaaacctt tttctatgct tttcgtatta catcagatca tcaccataag ggaggtgcct 2362681 tcacacaatg tttgtcatgg ttctaaggat tattttgctt gcactttttg cttattgtat 2362741 ttatgccgtg gtcaaatatg tcgcgaatcc taagagaagg cttaagctgg cccaatcaaa 2362801 agaacatttt tatattattg atgaacaaaa caatacccgg aagaattttc agctgacgta 2362861 taaaggcgtg ctttttgagg gagaaaagca tattccttcc aaggatcatc cgctgtttat 2362921 tcacacgatc tttgtctgga cagaatctcc tgagaagctg aaacatttct ctgcaaaaga 2362981 ttttgagaac attgaagaaa aagtgctgga acgatatcca aattgtaaga ttgactggga 2363041 ccagcccatt aaactcgcaa aaaaagcaga agagcgttaa acgcttttct gctttttata 2363101 aatcaaacgg gctgtagtaa atagcgatga gaatcgcttc tattaccaga agaagcggta 2363161 ctccgtactt aaaagaagcg tgtttcgttt tatgtctgaa ggtttgcatg ccaagccaga 2363221 caccgagcgc tccaaacacg atggctatca gccacagccg gtcttcagaa attctccact 2363281 tgtgctgctg cgctttgcgt ttgtcaatgc ccatcaccca aaaaccgcac agattaatca 2363341 acaccaaata agcagcaata atcatgttgc ctcatccttt atatagaaaa agccgctctg 2363401 ctggagagcg gctctatatg attacttgtt taattgagct ttagcagcat cagcaagctg 2363461 attgaatgca gtaagatcgt ttacagcaag atcagcaagc attttacggt ttacttcgat 2363521 accagaaagc ttaagaccgt gcattaaacg gctgtaagaa aggccgttca tgcgagcagc 2363581 tgcgttgata cgagtgatcc aaagtttacg gaaatcacgt tttttctgac gacggtcacg 2363641 gaaagcatag tttccagatt tcatgacctg ctggttagct actttgtata atgtatgttt 2363701 tgaaccgaaa taaccttttg ctaatttaag aaccttttta cgacgcttac gtgtaacagt 2363761 tccgcctttt actcttggca ttgaatttcc ctcctaattg ttccttatcc gattacttga 2363821 tgttagcaag catttgtttg atacgtttga agtctcctgc gcttacaaca gcactcttgc 2363881 gaagcttacg cttttgcttt tgagatttgt tggcgaataa gtgacttgtg tacgcgtgag 2363941 aacgttttaa cttcccagaa cctgtctttt taaaacgttt agcagatccg cggtgagttt 2364001 tcatttttgg catgggattt cctccttatt gcttttcgtt tttcggtgcg agcattaaga 2364061 acatgctgcg gccgtccatt tttggttttg tttcgactgt cgcaacctca gcacatgctt 2364121 cggagaaacg gtctaataca cgctgaccga tttctttatg agtgattgcg cgtcctttaa 2364181 agcggataga agctttcact ttatcgcctt tttcaaggaa tttaatcgca ttgcgcaatt 2364241 tcgtgttaaa gtcatgctca tcgattgtcg gacttaaccg aacttctttt aagttaatga 2364301 ttttttgatt cttgcgtgct tctttttcct ttttctgctg ctcaaatcgg aacttaccgt 2364361 agtccatgat tcggcagaca ggcggttttg cattcgctgc aactaacaca aggtcaagat 2364421 ttgcgcggcc ggcgatttca agtgcttcct gacgggactt gattccaagc tggtcgccat 2364481 tttgtccgat taaacggacc tcacgtgcac ggataccctc attaaccaat tgatctttgc 2364541 taataatgag ccacctccat agtttcttcg aattgattca caactcattt tgaatgcatt 2364601 ttgcaggcaa acaaaaagtg tgggcattat aaaacaccca cactacgaac atctgtatca 2364661 ataaaaatgt acggtcaacc tgccaactac atgcatgtgt caatcaggtg agaagcgggt 2364721 gcttctgctt gtgatttata ttcaattcaa taactattct acacaatacc ggatctttag 2364781 tcaaggacga cttatccgga acaactttta cattgtaaca tgggttttct atgagcgcaa 2364841 gagagaaaaa gaaaatcttt catccccacc cagaatacaa agaaccaaca attccccctt 2364901 attacgcaat ttacaacaaa accaccgaca ggaagaaatg taaaacaaag ttaatctctg 2364961 accgatataa ggagcagaag ggagcctgac acatgaacaa actgatacag cttgctttat 2365021 ttttcacatt gatgttaacc ggttgctcga atagcagcac atcttccgaa tcaaaagtcg 2365081 aaaccactgt taagacaacg gcagcatttc ctcaaaagga gctggagaaa gagctaaaaa 2365141 aactaaaacc cgtttcattg gacatgaagt tcgagagtcc actcgctacc gagttaggaa 2365201 agcggaaggc aaaagaggaa gctgaaaagc aaagacaaat cgccgctgag aaaaagcttg 2365261 aaaaagagcg ggaggcgaaa cgaaagaaac agcaggagga aaaagcggag agacagcgat 2365321 tagcagagca gcaggctgca gagagacagc gattagccga agcggaaaga caagctgaac 2365381 ttgaaagaca gcggcaggca gcaatccaaa aagagcagaa agcgaacgct gagaaaaagc 2365441 ggcaatcgca ggcacaacgg cagcagactg aggcaccctc atctaatagt caagatccac 2365501 catcttcctc gagtcagaca gataaaacca ttcaacagcc agcttcagag cttcctgatg 2365561 acgatggtta tggttatgaa gaacgaaaaa agtggcatga cgatcaagta gaatggggca 2365621 ttaaacaagg gtatatcgat cccgaagacg caccataaaa taaaaaaagc caaggcattc 2365681 agccttggct tatcctccga tcagctgcac gaacacaggg atgaccagaa ccgttaccac 2365741 tcctactacg acaacagcaa tacttgccat cgcagcttca acttctccca tctcaatccc 2365801 gaccgctaca ccaagtgcat gtccggatgt tccaagagcc aatcctttag aaatcggatt 2365861 tttcacttta aacaccttca agaacaatgc tccgagcgca tatacgatga cagcgttaaa 2365921 gatgaccgca aaggctgtga tgtcgctgat gcccccgatg ccttttgata aaggaagcgc 2365981 aattgccgtt gtagccgcct gcggaagcat gcttttcatt acggccgaat cgagatgaat 2366041 gcctttagcg agcagataaa caatcgtgac agagcagata gagccggcaa taatggaggc 2366101 catgatttgc caccagtact ttttaagctt atctctttgt ttgtacaaag gaattgcaaa 2366161 tgcgatcgtt gccggttcaa gaaaaaactt aatgatctct cccccgttat tataatccgc 2366221 gtaggaaaaa ccgccgattt ttaaaaatgc gatccccagc accatggcaa caaacaaagg 2366281 agtgaaaagg aagaagcctt tcgttttctt aaataaaaag gtgccgatgc cgaatgcagc 2366341 aagtgatacg acaatcccaa aataaggact cattgtgctt tccatgtgaa gaacctcctg 2366401 tttcccttaa tggtgaacga gttcgttatt gttctgcggg ctttgcactg tttttgtttt 2366461 catgtccgct tcggttttgc gttttccgct cagcgacaga atcagctgag aaaacaatcc 2366521 cgtagccccc agcaaaataa tcgttgcgag cagaatgaca agaacaattt gcaggccgta 2366581 ttgctgcatc acaccaagcg aattcataac agatatacct gatggaacaa ataaaaatcc 2366641 gatcagagag gttaaagacg ttccgagcgt ctccacttgt tccagtttaa tgactttcaa 2366701 acataatagg agaaataata agaccaaccc tacaaccgat gccgggatag gtattgggac 2366761 aatagcggca atcatatttg aaaccagcat aatgacggca aaaataaatg cttgtgttaa 2366821 aaacccgtac acttttttag cactcatttt cttcacctct ttctctttgg taccctcatt 2366881 ataaataaga attccctgtt ataaagcgct tacaagataa catgccgtat agcgggtctg 2366941 agttgcagaa tcaaatggct gaaatgcaaa aagccgccca tcaaatatgg agcagctttt 2367001 tcaattcctt cgcatatgtc cggctgaccg gtattttcga tccgtctttc atgatcagat 2367061 tatacgttga attaaaccat ggctgaattt ctttaatata ttcagtattc acgacaaagc 2367121 tccgatggac gcggataaaa tcagaatccg gcagcttttt ctcaatcaca acgagtgtat 2367181 cgctgaccgt ataagaatga tcgaaggttt ttacattgac atgaccatct tctgttccgg 2367241 catagataat gtccttcgta tccacaatca caatcgattc ccccacagat agcgcgagct 2367301 tgtgctggcc ggcatggctg ttttgctctg tttctacaat atcccgattg acttttttat 2367361 attttttcag cgtttgctga attctttctt catcgaaagg cttggttaaa taatcaagag 2367421 cgtccacctc aaacgctttg agcgcatact ggtcatacgc tgtcgcaaac acaatagcag 2367481 gaggatgctt cattttcttc aatcgctttg cgatatcaaa accgttttct ccggataaat 2367541 caacgtctaa aaacagcaaa tcaggttttt gatccatcat ttggtcaaaa gcggattcga 2367601 tattttccgc ttcattgatt tccatttcat cattggtccg cttaagcaag taagccagtt 2367661 catcccttgc cagcatctca tcatcaacta ttaacaccct gagcatgttc ttctccctct 2367721 ttcatctgtt gcattggcac ttgaaaggaa acctctgtcc ctttatgaac ctcactgctg 2367781 atatgcagtg cagcctgctg tccgaataaa ccgatcagcc gctgatttag gttataaagc 2367841 gctgtaccgg ttccctcctt agacggaaac ggtttcttcc ccagttccgg caagacgtcc 2367901 ggcggaattc cgcgtccgtt atccgccacc ttcatataga cggatgcatc atcagataag 2367961 acacagactg taaccttgca tatgtcttgt tttttcggaa acgcgtgccg aagcgcgttc 2368021 tcgacaagca cctgcaaaac aaacggaggg atttcaatct gctccagtct gctgtcgata 2368081 ttaagctcaa ttttatattt cccgggaaaa cgcgcctgtt ctaatgacaa ataggcgtta 2368141 agatggttca gctcctttga gagcggaatc agcagctgtc tcgctccttg aaggtttgaa 2368201 cgaaaataaa cactgagctg caataggagc ttacgggttt tttcaacatc tgtacggcat 2368261 aacgcagaaa tcgtgttgat cgcattaaat aaaaaatgcg gattcacctg tgcttgaagc 2368321 gctttaattt cagcatcctt gagaagtttg ctttgcagct ctgcttcccc aagctcaagc 2368381 tgtgtcgaaa acagcatggc cagcccctcg gcaagttcct cctctacctg actcaggcct 2368441 gccgggcttt taaagtacat ttttaaggtg ccgattgtat tgccgttcga tgtcagcggt 2368501 aggacaattg cagcgtgcaa agggcattca gcatgcgtgc attcaatctc ttcctgcgaa 2368561 atcgccttca taatatgccc tgttttaatc acctttttgg acaggccggt gatcaagctt 2368621 ttcgatggga tgtggtgatc cattcccgca ccgacatgcg caaggatctt ttctttgtca 2368681 gtgagagaca ccgcatctgt tcctgtcagc ttatggataa tagccgctac acttttacag 2368741 gagttttcat ttaatccttg gcggaaaaat ggaagtgtct gatcagcaat cgtaagcact 2368801 cgatgcgttt cgagagccct tgcctgttct tccttgcgaa tgatcgcttg aataatagac 2368861 agaaaaataa aactgcctgt tccattgatg agtatcatcg gaattccgat catgctgaca 2368921 agctcccaag cgtcactgaa cggctttgcc atcagcaaaa taatgatcat ttgcagtgac 2368981 tccatgccga ttcccacaag agcggcgatg cgcggtgtcg gcattcgata tcgcttcgta 2369041 aaatacctgc cgatcaagcc tgcaagaaca cccgctaaaa tagatgagac ggcacagctt 2369101 aaggccgtgc tgccaccgag tgaaaaacga tgcaggcccg caagtatgcc gatcccagcc 2369161 cctacaaaag gacctccgag aaggcccccg atttccacgc ccaaaatacg ggtattcgcg 2369221 atagagcccg atggatctat cgtaaacacc cagtcattgt ttacaatcat atttctttga 2369281 atttcgatgc ctgtataatt gctgatgatg ctgaaaagag aaaaaataga aattaaaatc 2369341 gcttttcctt tatagccgtc ctgattctga agagcttgtc tgaaaagttt cgtatgggcg 2369401 agaatgaacc ctaatataac aataatcccc actctctcca gcatcataat cattaaatga 2369461 atcattcatg tcacctgttc tttccgtttt cattctagca tgttttcgtt ttgcggctga 2369521 ctgttttttt aaaatcgtct gaaaacatat ttcacaaggc ttttatctat tgtaaaataa 2369581 aacatgagcc ttttggcaga aagatttgaa tctgaagcag aggagaagat catgaaagcc 2369641 gtattttttg atttagatga tacactactt tgggacgaaa aaagcgtcag aacaacattt 2369701 gcagaaactt gcttacaggc ggagaaaaaa tatggccttg cccctgagga attcgaagca 2369761 gctgttcgcg aagcggcgag agaattgtac atgtcatatg agacgtatcc atatacagtg 2369821 atgatcggca ttaacccgtt tgaaggactg tggtccaatt tctcagagcc aatcagtgaa 2369881 ggctttcaaa agctgaacaa gattgtgccg gagtacagaa gaaatgcatg gaccaacgga 2369941 ctgaaagcgc ttgggatcga tgatcctgca tatggcgaat acttgggaga gttttttgcg 2370001 gcagagcgca gaaagcgccc gtttgtatat gatgaaactt ttgctgtact cgatcaatta 2370061 aaaggcaagt atgaattatt gcttttgaca aatggcgatc ctagtctgca aaaggagaag 2370121 cttgccggcg tgcctgagct cgctccttac ttcaatgaaa tcgtcatctc gggcgcattc 2370181 ggcaagggca agccggatgt ttcaattttt gaacactgcc ttaagctgat gaatattgaa 2370241 aaagacgatg ccatcatggt cggcgataat ttgaatactg atattttagg cgcttcaaga 2370301 gccggaatca aaaccgtttg gatcaaccgg actgataaga aaaacgaaac tgacgtaaag 2370361 cctgattaca tcatcagcag ccttcatgat ttgtttccta tattagagaa ataaaaaaag 2370421 catgatctct tcaatgagat catgcttttt tattttattt tttcgcttca gctactgcct 2370481 ttttcacaaa ctcatcaagt gaaatggttt cagagttctg ttctccgtat ttacgcacgt 2370541 ttaccgctcc gttttctgct tcttggtcac cgaccaccag catgtacggg attttttgca 2370601 tttgcgcttc acggattttg tagccgattt tttcatcgcg gctgtcgact tcaacacgca 2370661 ggccttcaca ttgcaggcgt tcctgcactt ttttcgcgta gtctaaatgc acagccggag 2370721 aaaccgggat gacttggaac tgaaccggtg caagccatgt cggcagcgcg cctttgtgtt 2370781 cttcgattaa gaaagcaaca aagcgttcca ttgttgaaac gacacctctg tgaatgacaa 2370841 ccggacggtg ctgcttgccg tcctcaccga tgtatgtcag gtcgaaacgt tccggcaata 2370901 agaaatcaag ctgaaccgta gacagtgttt cttcttttcc gatcgcagtt ttcacctgaa 2370961 catcaagttt aggtccgtag aatgccgctt caccttctgc ttcgtaatag tcgtggccga 2371021 tttcatccat tgcctctttc agcatggatt gcgctttgtt ccacatttca tcgtcatcaa 2371081 aatatttctc tgtatcttcc ggatcgcggt aagacagacg gaatgtgtaa tcacttaaac 2371141 cgaagtcttc ataaacatcc tggattaaac ggactgtacg gataaactca tccttaattt 2371201 gatccgggcg cacaaagatg tgtgcatcat ttaacgtcat tccgcgtacc cgttgaagtc 2371261 ctgacagcgc acctgacatt tcatagcggt gcatcgttcc aagctctgca atacgaatcg 2371321 gaagctcgcg gtaactgtga atgtcttgtt tgtaaatcat catatggtgc ggacagttca 2371381 tcggacgcaa tacaagtgtt tcattgtcca tttccatcgg agggaacatg ccttcctgat 2371441 aatgatccca gtgtcctgat gtttcataca gctctttgct gcctagcaca ggtgtgtata 2371501 cgtgctcata gccgaggctg atttctttat cgacaatgta gcgctcgatg acgcggcgga 2371561 ttgttgcgcc ttttggcagc caaagcggca ggccttgtcc gactttttga gagttcgcga 2371621 acagctttaa ttctttgcca agctttctgt ggtcgcgttc tttcgcttct tctagcatac 2371681 gaagatgctc ttcaagatca gcttttttga agaaagctgt accatatacg cgctgaagca 2371741 tttggttttt gctgtcaccg cgccagtatg cgcctgcaag gcttaacagc ttaaattctt 2371801 tgatttttcc ggttgaagga acatggacgc cgcggcacag gtcaaagaat tcgccttgct 2371861 catagatcga aacggtttct ccttcaggaa tcgcatccaa tagttcaagc ttcaggtcgt 2371921 cgccgatttc cgcaaaacgg gctttcgctt cttcacggct gacttctttt cgaacgatcg 2371981 gaaggttcgc attaacgatt tttttcattt ctttctcgat tttcggcaga tcctccggtg 2372041 taatcgcttc gtccatttct acatcgtagt aaaaaccgtt ttcgataacc ggaccgacgc 2372101 cgaatttaac atccttgtag atgcgtttaa tcgcttgagc cagcaagtga gccgcactgt 2372161 ggcgcataat ttgaagacct tcttctgagc cttctgtaat gatttccact gtaccgtctt 2372221 cattgatcgg cgttctcaaa tcgatttctt ttccgttcag ttttccggct aatgactttt 2372281 tctttaatcc cggactgatg gatgccgcga tatcttctgt tgttgttcct ttcgcaaact 2372341 ccttgactgc tccatcagga aatgtgattt ttaccatatc tgacatcttt gtcactcctt 2372401 tttttgcata taaaaacccc gccccctatg aaagggacga ggttgaataa acggaatcgt 2372461 ggttccaccc ttttttccgc aaagccaata cacggcacct gcggctctaa gctctgtaac 2372521 gggagttccc gtcagccatt actgttcctt ttcaagaggt tcacagctga agttcaaagg 2372581 cggtaaagcg aatggtcctt agctgggaag cttgcagcca gggcttccct ctctttgagc 2372641 cggtatcatt ccttcgtgtc cttatcaata cgtgtgtctt tcttaatctc ctatgtatta 2372701 taaattgttc aatccaaaaa atcaacacga tcgcgtttcc ttttttttaa accgacagcc 2372761 ttaaatagac aggctgccgg ccctcatcct tccgagtgct tcaccggtat ttctgcatct 2372821 gtaaaagcat gcagcgggag catttccact ctctcttgaa atacgttttg aatggtcctt 2372881 gccatcatgt gctcgggctg gtcggtataa agcacgactt catcaggcgc aatggaaatc 2372941 agcggcgcga gcaaatgaga atcaatatac ataggatgat cccggacaaa tcttctgtct 2373001 atgtatttca ttttttcccg ttccggcaca tagcgcagct cccataatgt aaaggaacca 2373061 tcatggacaa tatgcacttt tttgattcgc ggctgtttgg cgtccacata gtctctgagt 2373121 gtttgaataa agttttgata ttcctgttcc atcttatatt catcaatcgc tgcttctgta 2373181 atatctctca gctgcttata gtatgatcca agtcggaagg tctgaaagga gcgaatgtaa 2373241 aatactcctt cctctaaaca gatcgtttgg agttcatcca aaattgattg tttccgtgaa 2373301 agcttcagcg gctcaaacgg aagatcgtct gcttcacctt caataatact gtgtgcgagc 2373361 tgaaggattt gctgctgttc atcctggtcc gtgaaacaat acgtttcctc aatcaatgac 2373421 agcatatgct cgtcttcttt gcattccaaa aaaaatttga ccagaatcgg ctccataaaa 2373481 cgctgaatag gaaaagccgg attcgctttt tcaatcccga tttttcgtat gccttcacgg 2373541 acaatgatat tgttccgatc gtccgaatgc tgaatgagat gtaaaaaagc ggctgcatca 2373601 tggtcatctt caaagattat ttcaagcatg tttgtccccc cttacggcat ctgttacaag 2373661 tatatggggg atgtttttaa aatagacgta aaggtcattg gcaaatctta atttgattct 2373721 tggaacaagt tttgcatttt ctttctgaag atgaacggca atgagataaa cacgatatac 2373781 aaagcgagca ccataaagaa agcgggcaga ttgccagcca aaaagctcgc acccagcaca 2373841 ttaagcgcaa tcgtcccagg gatgattccc acagccgttg cggcaaaata cggcagcgct 2373901 ttgacattgg aaaggcctgc cgcatagctg acgaaatcaa aattgatcgg caggattctc 2373961 aaaagaaaga tatagaaaaa tccgttatcc tccatttgct tctgtatggc ttcaagcctt 2374021 tcgtaatgcc cgttcttttt cgccgaaaac aaaccagccg caaaaaacga aacagctgaa 2374081 gcgcacatcg aaccgaataa cgtataaagc gtgccgagaa gcgggccaaa cgcaagtccg 2374141 ccagctattg aaataacaga caccggaaat aaaacaagtg gcctgacgat ggatatcccg 2374201 ataaacatca gaggtgcaaa gactccgaac gacaataccc ataccctgat ttctttcggc 2374261 gatacattca aatacgtttt atttccccaa tagagtaaac cagcacctgc aagcactgcc 2374321 agccatttga cagccgtttt tcgtttcata ccctcagttc cttccccttt gaaccacagc 2374381 aattatggat gtcggcggtt ttctccgtca aggcggatcg gagcagccaa atataatatc 2374441 cgctccatta atcttgcagc ttttacttct tctttttctc ccctctgcga atacgtaaaa 2374501 tgatgcttca gctcgtcagg tgagaaatta gaagaaaaga acgttggcag ctgctgggac 2374561 attctgtgct gaagcaccgt tccgatgacc tcatccctta cccagcttgt cattgattct 2374621 gctccgatgt catcaagcat taatacgggt gtggtcttta ccatattgag cttctcttcc 2374681 aatgtctggt cttgcagcga attcttaagc tctctcacaa attcaggcac ataaacaatc 2374741 atggaggaat actctttttc cgccagctca ttggcaattg cagcgagcat aaacgttttt 2374801 cctaccccaa atttcccgta taaatataat cctttccctt ttcccgtctc attatagctt 2374861 ttcaggaagt ctgtaacatg ctgaaacatc gcgagtctgc ttgggtcact gatatcaact 2374921 tgctggaacg tcgctccaag aagatcctgc tggatataca tgcttttcat aagagactgt 2374981 tgtttcttct gctggtcgag cttccgtttg actggacatt cgtaatactc gatatcaata 2375041 gacctcccat tgacaacaag cttcggatgg tagccctcca acaaattgtt gcagttttca 2375101 tcttccgaac aataggagca attcttgctt tgttcgatat attcataaag cttatttaag 2375161 ctcttttcga tcattttttg gtcaatcact tcttcgtttt ccttcaaaaa tgcttgaaca 2375221 tcttgatctt tcatgacttt ttccttcatt tgttcaagac gtttttggaa atccggcctg 2375281 ccggttacgc cctgcaggga acggccgatt ggttccatct attccttcac cccgcatctc 2375341 tgtctttaat aggcagagta ttttttcagt ttttgcattt cttccatcat ctttttcttc 2375401 tgttcttcca aatcctgcgg atgcagcttc tgctgtccgg attctgaatc ggacgctgtt 2375461 tccttttctg tcatccaatc aggaagcttt tcttcacgaa tcactttttg gtttcgtttc 2375521 gaagactttg tttttccctc agcccattca agatactggc ggttttcttc tattgcgagc 2375581 ttcatcgctt ccctgaccgt tttcaccttt ttgcgtgccc aatgcgaagc gattttttgg 2375641 atatagtttt tcgacagctt catgtcggtt ttcagcatga cataataaat taacacattt 2375701 gtgacgcctg gctcgagctt ctgttcgaac ataatttctt ctatgatctt cagatcagct 2375761 tttgacggct ctgttccgtc agcaatgtcc tgcagaagct tcttcgggga aatcgcctcc 2375821 agcaatgcaa tcagcttccc atccagagaa tcctcttctg ccggttgttc gccttcacgc 2375881 agatgcaccg gctgtgtttt ttccaccaaa tcgggcagct gtccgtttct ttcaatttga 2375941 taccagtcgc tcgccgcttt tcttaatgcc tccgtcgtaa tgacgtcacg ctcatcaatt 2376001 gcgctcatca caacattttg catttgcaaa gggtcaattc cgtacagata agaaagcttt 2376061 ttgattgtgt cccgcacctg ctgggtcatc gcttttctcg gtatcatcgt ctcagaaagt 2376121 cccgctaaaa acaaatcaaa atcaaacaca tcctccgtta tggtgtagga cggagactgt 2376181 ccgacagaag tatactcgga cccctcggca agccttaccg tttcctccat atcggatgtg 2376241 agcttccatt cactcggctg cagcgattca aacgcatgat taaacggacg cgtaatgtcc 2376301 ttcgcatctt ctgaaatggc cgggtgcgta aaaaattgtt ttaattgctg atatttcgtt 2376361 tttccgaccc tattatacag aaaaacattc agcattccgt cttcaaaaaa ttcatttggt 2376421 ctgagcggcg gaaggagttc atatataaag aggcgctcct gccgctcgga ttctttcata 2376481 tatactttca gcaatccgat gccctcgagc ttcccctgtt cctgatggat cgtttttaag 2376541 ttggactgtg tcatccccat cagctgtcta tgtgtggact ctccgcccca cagacggttt 2376601 tgttcaagct ctccccacaa tgtcatataa agagagaatg caacagggcc gattaagggc 2376661 tggtacagtt gtgtaataat ttgtctgtca atatcctgca gcatcgatct gcttttaacc 2376721 acatacgggt ctacaggcag tacatctttc caatagtcag ccatacattc tcaaaccttc 2376781 cgaatttgtt tctacctttc attttacacc gtttcttata tctatcaaat gccaattttg 2376841 cacatgagaa aagagctaga agaatcctct tagctctttt aacgctcttt ctttattaag 2376901 tcttttaatt catcgataaa gacgtttata tctttaaact gccgatagac ggacgcgaac 2376961 cgcacatatg cgacttcgtc aatcttagcc agccggtcca tgaccatttc tccgacgagc 2377021 tcactcttca cctcggagca gccttgattg cgaagttctt tttcaatatc aaagcacatg 2377081 tcttcaagcg ttttgagtga aacaggcctt ttttcacatg cttttatgag gccgcgcagc 2377141 attttttctc tgctgaattc ctcacgcaca ccttcttttt tcacaacgat gagcggggtt 2377201 tcctccactt tctcaaaggt cgtaaaccgg tagtggcagg attcgcactc gcgtcttcgg 2377261 cgaatcgact ttccgtcatc cacaggccgt gaatcaagga ctcgtgttcc gttatgctgg 2377321 catgaaggac atttcaataa aatcagctcc caactatatc gttccctgca atgtattttc 2377381 ggcagcctcc gccttttaaa aatagatgtg acagcatctg tcgggagagc cgttgttaaa 2377441 tttgtttcta tagcattagg tggtttgtga aaatctcctt cttattttac aaaaaaaatg 2377501 aaaaaagaaa aagctgacac tctcgtttct ttataaaaat aaaaggagca taagctaaaa 2377561 agcgcataat ggctttctag cttcagctcc ctttgtgttc gcaatttact ttatagtact 2377621 ttcgcttgcg cctgtttaat ttgcacaggc cccattcctc ttggtatttc aatgttttct 2377681 cttgtatcag catgtaatgc ctctgcaatg taatcagcag cgacattagg atctaagtct 2377741 ccacaagtat aaacatcaat gctcgcatat ccgtgctcag gaaaactgtg aatcgttaag 2377801 tgtgattcag aaataatcac aactccgctt acgccttgcg gtgcaaattt gtgaaatgca 2377861 acctcgcgca cctcagcacc tgattttaga gcagcattta caaacgtttt ttcaataaaa 2377921 tccatgtcat tcagcttatc aaaatcgcat ccccatagct cggagataac gtgacgcccc 2377981 attgtttcca tagtcatgga ccccccttaa caagaattaa aaagtgaaat tccaacaact 2378041 gggtcggcca tttaccacgg gggaaagtta gtccggagag gtcctaaccc tttaagtaat 2378101 tccgaaacag tctcaagcaa gaagttcacg aaaaatagta tactgtgttt aagtctaatt 2378161 tgcaaggtgc gttttttcag aaatatgctg ttaagggttt tttctttaaa atgtgtccat 2378221 gaccttattt tatacagcag acggatgttt cattcgtgcc gctacatggc ggattagatc 2378281 aacaactctg caggagtagc cccattcgtt gtcataccac gccagcacct ttactttcct 2378341 gtcttccatt accattgttg taagcccgtc aatgaccgct gaatgcggat tcgtattata 2378401 atcagtcgaa acgagcggtt catctgagta atcaagtaca ccgtacatcg acgttttggc 2378461 agcgcgttta aatgcctcgt ttacttcttc agccgtaaca tccgttttca gatcaacaac 2378521 gagatcaacc aatgagacgt tcggaacagg gacacgcaag gcgaggccgt gaagttttcc 2378581 tttcagatgc ggcagcacaa gcgaaagcgc ctttgccgct cctgttgttg ttggaatgat 2378641 ggattcaccg caagcccgcg cccggcgcaa atctttgtgc gggttatcaa tatttttttg 2378701 gtcattcgta tacgcatgaa ctgtagtcat cagaccgctc tcaatgccaa actcttcatc 2378761 cagcactttt acaacaggcg caaggcaatt tgtcgtgcat gacgcatttg aaataatgac 2378821 atggcgctca gcgtcgaatt ggtcctcatt tacgcccatc acaatggtaa cgtcttcatt 2378881 ttttcccgga gcggtcaaaa tcactttttt tgcacctgct tctatatggc ccatcgcttt 2378941 atctttagca ttaaacttcc ctgttgcttc gacgactatg tcaatatcat attcccgcca 2379001 aggcagctgt tttggatcac ggctgtttaa caaaagcact ttctttccat ttacgatcag 2379061 gctatcttca ccagccacaa cctctttgtc gtatctgccg tgaattgtgt catactttat 2379121 taaatgagcc agcgtttctg cggaatagct ggcgttaatg gccactactt gaatttgatc 2379181 gtctaacatc gcttttctaa aaaccattct tccgattctt ccaaacccgt tgatcgctac 2379241 ttttaccttc atgttggaca ccccttatca attatgccat cctaatttgt tactatctaa 2379301 aattagtata acacattaaa acaaattcgc cagtacatat tgataaaaat caacgattat 2379361 aacgctaatt tatgatgcat cttatgtttt cttgcacaga atatcaggcg taagaaccaa 2379421 aaagcagcca gcgctccgca ctgactgccc tcatgcttta tgattcctgt tttaacttat 2379481 cattgagcac actttcttct agcacagaaa atgtatcccc gtacactctg ttaatatgat 2379541 tcgctcccca agcacacagc atatctaaaa tcccttctaa gctgcggccg tattcgctga 2379601 gctcgtattc cactttggga ggaacttgat tatatacgat tcggttaatg acaccgtccg 2379661 cttccagctc gcgcagctgc tgagtcagca ttttttgcgt gatattgggc attaggcgtt 2379721 ttaattcact tgtgcgtttt tttccgtgcg tcagatggca taaaatgacg catttccatt 2379781 tcccaccgat cacttcaaga gtcgcttcaa cagaaatgtt atattttttc ttctccatac 2379841 aatccattct cctcacaggc accaaaaagt gactatagca cttcaaagta cgtactttta 2379901 tttcttaacg atatgtttca taatcacatt tgccggctga tttgaatctg ctctttttta 2379961 tttatatagc ttactcggca gaatttcaat catacaacac atcttacaaa ggaggaacat 2380021 catgacttca gccaataaaa gcaatattcc tgcactactg gctttggccg taagtgcatt 2380081 cgcaataggg acaactgaat ttatcagtgt cggccttttg ccgctcattg ctgatgacct 2380141 ggatattccc gtcacgacag caggattgac cgtttccctt tatgcgctcg gcgttacatt 2380201 tggggcacct atattaactt cattgacctc aagcatgtca cgtaagacac tattgctttg 2380261 gatcatgttt atttttattg ccggtaatac gatggcagca accgcttcaa gcatcgggat 2380321 tttactagca gcacgtgtga tatcggcatt ttcgcacggt gtgtttatgt cgatcggttc 2380381 gacaatcgca gcggatattg tcccggagga taaaagggct agcgcgattt caattatgtt 2380441 tactggcctc actgtggcaa ctgtaaccgg agttcctttt gggacattta tcggccagca 2380501 gttcggctgg cgtttcgcct ttatggtcat tatcgccgtc ggaatcattg ctttcattac 2380561 aaatggcatt cttgtaccgt ccaaattacg aaaagggacg aaaacaacga tgcgggatca 2380621 attgaagctt gtgacaaaca gccggttatt gcttttattt gtcattacag cgcttggata 2380681 cggaggaaca ttcgttgtgt tcacgtatct gtctcccctg cttcaggaag taacaggctt 2380741 caaagccggg actgttgcag tgattctgct cggatacgga atagctattg ctatcggcaa 2380801 tatgattggc ggaaagctgt caaaccgaaa tccgattgcc gctttattct atatgtttat 2380861 cgtacaggca atcgttctat tcgtactgac atttacagcc ccgtatcaag cagcagggct 2380921 cattaccatt ctctgtatgg gattgctggc ctttatgaac gtgcccggcc ttcaggtgta 2380981 tgtcgtcatg ctggctgagc gttttgtccc gagtgcagtt gacgtcgcat ccgcgatgaa 2381041 tatcgctgcc tttaatgcag ggatcgcgct tgggtcatac cttggcggtg tgatcaccga 2381101 ttcaatcgga ttgattcata ccgcttggat aggcggatta atggtggtcg gtgcagtcat 2381161 tttaacaggc tggagccgct tgatggaaaa acgagatcgg caggaagcct gacaatttta 2381221 aaggaggaaa taaacatgac aacacattta caagcaaaag caacacttca taatggggta 2381281 gaaatgcctt ggttcggcct cggcgtgttc caagtggaag aaggatctga actggtaaac 2381341 gcagttaaaa ctgccattgt tcacgggtac cgcagtattg atactgcagc aatctatgga 2381401 aatgaagctg gagtcggaga agggattcgg gaaggcattg aagaagcagg catttcaaga 2381461 gaggatctgt ttatcacatc gaaagtatgg aatgcggatt taggctacga agaaacactc 2381521 gccgcgtttg aaacaagtct gtccaaactc ggtctggatt atttggatct atacctcatc 2381581 cactggcctg tagaaggaaa gtataaagaa gcttggagag cgcttgaaac gctgtataaa 2381641 gaaggccgta tcaaagcgat tggcgtaagc aacttccaaa ttcaccatct tgaagatctg 2381701 atgacggcag ctgaaattaa gcctatgatt aaccaagtgg aatttcaccc gcgcctcaca 2381761 caaaaagagt tgataagata ctgccaaaat cagggcatcc agatggaggc ttggtcacct 2381821 ttaatgcagg gacagctgct ggatcaccct gtattggctg acatcgctca aacatataat 2381881 aaatctgtcg cacaaattat tttgcgctgg gatctgcagc atggcattat aacgattcct 2381941 aaatcaacga aggaacaccg cattaaagaa aatgcaagcg tatttgactt tgaattaacg 2382001 caggatgaca tgaaccgaat cgatgcactg aatgaaaact tgcgcgtcgg tcctgatccg 2382061 gacaactttg atttttaatg gccaaaaaac accgttcaat atgaacggtg ttttttgtat 2382121 tatgcccagc tgttcatgat ttcatcaagc tgccttttgg tctcttcaag cgtgccgctg 2382181 ttatcaatga cttgatctgc tcttgctgtt ttttcctcta agggcatttg agagcggata 2382241 cggctgactg cttcttcttc tgtcagctga ttgcgcttca tcagacgttc cagttgaagc 2382301 tcttttgtca cactgaccac aataatttta tcaaccaatg attccaattt gctttcgaac 2382361 aatagcggga tatccaatac aacaaatgcc tcccgatttg caacggcttc atcacggcga 2382421 ttgagcattt cctgcctgac tgcgggatga acaattgcat ttaaagcgag acgtttttgt 2382481 tcatttgtaa ataccagcgc tccaagcttt tttctatcta tatcgccatt tgagagcagt 2382541 atgtcttcac cgaattcgtc aatgatttgc cggtaggccg gcatcccttt ttctaccgct 2382601 tgttttgcaa tgatatctgc atctataact gttattcctt tttcaatcag catattggct 2382661 accgtgcttt tgccgctagc tattcctccc gttaaaccaa tgactaaggt caagagatcc 2382721 actccttttt acaatttcca gagcccaatc gtgattaata gaagccccgg caaaaacgcc 2382781 attttatcga tccatttcca cttagacaga aaatggccgg cattgattcc aattgataca 2382841 aacagcgagc tcatgattgc cacggcgatg ctcatcacaa tcggcgaaaa accgagaatg 2382901 gctgcgccta tacctgctcc aaaggcatca atcgataagg caaatcccaa taagaccgcc 2382961 tcaattccgt tgatcacacc cgatttgtcg atatccgcac tcatgggttt tctcaaaata 2383021 tgaatcacaa ttcctaatga ccgaacctct agattaagca gtgttttttc atgcaatagg 2383081 tattctttat cttttgccgg tttgaaaaat tgatacagaa cccacgcacc gattccaacc 2383141 aatatcaaac cgccaagctt ctccgtcaca tatacaggaa aaaacttcgt gagaaagctt 2383201 ccgatcagca tggatataaa catgacagca ccggaacagc aggcgataac caaaatcgct 2383261 ttaaacggta ttttcatttt tctcaatccg tacgtaaatc cgactgaaaa actgtccaag 2383321 ctgacagcca acgccagcag cagtatagaa accatttgca tatccgtttc ttcctttctg 2383381 ttggtgctct tgtatcagat gtgaaatgcc cgggattcat cacaatcata tatatgggaa 2383441 agtgaaaaat ccgtgtttcg aaaatggcat ccttaatcca gagttactga tatatgcacc 2383501 gacagcttgg acaatgaagc attatgctac ttttttgtct ggcactttgc gcaaaaatgc 2383561 gtgcctcttc ctccaacgac aattttcgaa atcatcgttc cgcaattttt gcatggctcg 2383621 tctttttttc cgtacacaaa atgctgcagc tggaacattc cgatttcccc ttgggagttg 2383681 atatatgaac ggactgtgct tccgcccgca tcaatcgcct cctgcagagt gtttttgatt 2383741 tcagcgtgaa gggttttgat tgttttatct gataattgat ttgcttttgt ctcgggatgg 2383801 acacccgctc tgaaaagagc ctcatccaca taaatgttcc cgagtccaac taccgttttt 2383861 tgatccagta gggcagtttt gacagcgcgg tttgttttcg caagccggtc ttttaaatac 2383921 gcacttgtaa attcttctgc atccggctcc ggccctaact gagaaagcgg gagctcgccc 2383981 gcttcttctc ccggtttaaa taagtgcatg gttccaaatt tccgcacatc cctgtaccgg 2384041 agctgggttc catccgtcat cgtgaatatg acatgcacgt gtttatcgtc aggctcctcg 2384101 gcttgatgaa gaccgtattt tccttccatt cgaaggtgag aaaccataac ataatgatct 2384161 aaatgaaaca gtaaaaactt tccccgtctt ccgatggact gtatcgtttc tcctgctagt 2384221 tttcgcgcaa attcctccgg ttcggcaggc cgtttgatga tattcggcca tctgatctct 2384281 accgatttga ttgtttttcc ctttacaagc ccggtcagag tgcgccggac cgtctcaacc 2384341 tctggtaatt ccggcacatc catcacttcc tatctctgtt tatttcgcat cgtaccaaga 2384401 tgggcctgat gcaaagtcca cctttaacgg cacatctaat gcaagcgcat gctccatcac 2384461 ttcaggaaca agcttttcaa gaatttcaat ttcttccttt ggcgcctcaa aaatcaattc 2384521 atcgtgtact tgaagcagaa gccttgcttt caactgtttt tctttcagct tggcagccat 2384581 gtcaatcatg gcttttttga taatatcagc ggcgcttcct tgaatcggcg tattcatggc 2384641 cgtccgctcc gcaaaacttc ggatattaaa gttccggctc gtcagctcag ggatgtagcg 2384701 gcggcgatgc ataagcgttg ttacgtatcc tttttgtttc gcttcctgta ctgaatcttc 2384761 catgtacgct tttacgcctt ggaagctttc cagatagcgg tcgataaatg ctcccgcttc 2384821 cttccgggta atgccgaggt tctgtgacag accgtaatcg ctgatcccgt aaacaatgcc 2384881 aaagttgacc gctttcgcct ggcgtctcat cgcagatgtc acttcatcct tagcgacatg 2384941 gaacacatcc attgccgttt tcgtgtgaat atccatatca ttagtaaaag cttcgatcag 2385001 attttcatcc tttgaaatat gggcaagcac ccgcagctcg atttgtgaat aatcggctgc 2385061 aaaaatgagc cagtcttttt cagacggcac aaaagcttgg cgaattttcc gcccttcctc 2385121 aagcctgatc ggaatgtttt gcaggttcgg atcagtcgag ctgagacggc cagtttgcgt 2385181 taaggcctgg ttaaatcgcg tgtgcacttt atgcgaatcc ggtctcgtca cctttaaaag 2385241 cccttcgata tatgttgatt gaagcttgcc aatttgtctg tactgtaaaa tatagtcgac 2385301 aatatcatgc ttgtcagcca gcttttcaag cacatcggca gacgtagaat agcctgtttt 2385361 cgttttcttt acgacaggaa ggccgatctt ttcaaataag atgacgccta gctgtttcgg 2385421 agaattgatg ttaaacggct ctcccgcaat ctcatggatt ttttcttcat attccttcag 2385481 cttcgcaccc agttcttcac ccatccgttt taaacggtca acatcgacct tgacgccagt 2385541 tgattccatt tcgccaagaa taagcgcaag aggcatttcc agctcttcaa acagttcaag 2385601 ctggtcgttg ttttccagct cttgaacgag cttttcccga aggctttgaa tcgctaacgc 2385661 ttttcggcca aggtgctcag acagtacgtc ttctgacggc actgcccgtt ttgctccttt 2385721 tccataaact gattcatcac ttgaaacgat atgcaggccg taatccttag ccacactcgc 2385781 aacgtcgtca tatgaattgc ccgggttgat gatataagcc gcaaggagcg tatcaaactc 2385841 ggctcctttc agctcaatgc cctgccagcg caaagcgaca acggcccgct tgctgtcgaa 2385901 gacccatttc ttctgctcgt cattttccac ccattcttta aacacctcag actcaacggc 2385961 aatgtctttc ggaatgaaat aagctcccgt ttcatttacg atcgaaaatc cgaggatcgg 2386021 ctcttcatga taattatcgc caatctgttc aacgacaaat gcggatggag aaaccaatat 2386081 atcgcttgtc acgtctgtga ctgttttgac attaatgtct tccaacgatt gatcctgttc 2386141 tgcttctgca ctgtcttctc caagccgttc aagaagcgtg ttgaagccaa gatctttaaa 2386201 gatggcaatg acctgttcac gattaaagcc ttgatattcc aggccggaaa cagatacctc 2386261 aatcggagca tccgtcataa ttgtcgcaag ctccttgctc atcaatgcct gatccttaaa 2386321 ctcctcaagc ttttccttca atttctttcc gctcacctcg tcaatggact ccagcagctt 2386381 ttcaacggaa tcaaattgtt ttaaaagctt aatcgcagtc ttttctccga cgccgggcac 2386441 acccggaata ttatctgagg aatcgcccat cagacccttc atgtcaatga tttgttcagg 2386501 cgtaagccca tatttctctt tgacatgctc cggtgtgtaa aattcaacat cggtaattcc 2386561 ctttctcgta atggcaactg tcgttttgtc cgttgccagc tgggttaaat ccttatctcc 2386621 tgagaaaacc ttaacttcaa atccgtcttt ttcagccgat ttggccagtg tgccgataat 2386681 atcatccgct tcatattgtt ccagttcata gcggctgatc tggtaggcat ccagcagctc 2386741 gcggataaac ggcatttgtt cggaaagctc aggcggggtt ttctgtctgc cgcctttata 2386801 ttctttaaat gtgccgtgac gaaatgttgt tttcccggca tcaaacgcaa ccagcatgtg 2386861 cgtcggtttt tcatcctcaa gcattttcat caaaatcatc gcaaagccgt atacagcatt 2386921 cgtatgaaca cctttatcat tgcttaacag cggcaatgca aaaaacgccc ggtaagccag 2386981 actgtttccg tctacaagca ctaatttttt tcgttccgtc attcaatttc ctcctaagaa 2387041 gcctcaggct tccattcatc tcttacatag tcattagctc ctcttatttt aacaaagttc 2387101 aatttgaaag gaaaatacgt gaactataag agaagacaca aaaaaggacg ggaacacaaa 2387161 taggttcccg ccgtcaaaat tggctccttg gatgaagggg ttctactaca tcctaccagc 2387221 ataggtttaa cagtgcatga agatattgtt aaacctttgt aaacattagg cggacttttc 2387281 agcggcccgt ttcagcgtca cggtaaagac agttccccgt ccaagctcgc ttgtgacatc 2387341 aattttccct tcatgagcct ctattaaatg cttgacaatc gctaggccca gcccggttcc 2387401 gcccgaattt ctgcttctgt ctttatctac acggtaaaag cgttcaaaga tgcgcggaat 2387461 ttcttctttc tgaattccga ttccagaatc ggcaacctca atctgaatgt ctttttctct 2387521 gggctttaca ttgatagcca cggagccccc ctcaggcgtg taggttaatg cattgtttac 2387581 gagattaaga aatacctgtt tcagcctgta cgggtcacca gatacatatt gagggtcttt 2387641 cgggacattc aggtgcaagg agatgccttt ctcatccgcc ttatgcttca gaagcgtttc 2387701 aatctcacca agcattttgg ccggctcaaa cgtttcgata ctgagcgtga aattttgctg 2387761 ctcgattttt gagagatcga gcaaatcctg aaccaaagac tgaagccttt cgctttcctt 2387821 aagaataata gagagaaatt cagaaagcgc ctctttgtct tccatcgccc cgtccaataa 2387881 cgtctccgta aaccctttta tggacgtaat cggtgttttc agctcatgag aaacattggc 2387941 cacaaaatcc ttcctcatct gctctaattt cttcgtttcc gtcatgtcat ggaaaacgag 2388001 cacaattcct ttccattcat cgtccggccc cataatcgga acgccgtcca cttcaaaata 2388061 acgccgttct attttgatcg gcagtcttaa cagcttgcat ttctttgtct ccgtcataaa 2388121 aatgtcttcg acaagctgga tcacttcttc atgttcaaat gcatcgtgat aaagacggcg 2388181 cagcatatga ttcggattga tatgaaactg cttggcgtaa gacctgttta cgagattaat 2388241 aaagcctctt ccgtcgatca taatcagccc ggagccaatg ttttcaatga ctgtcagcag 2388301 ccgatcccgc tgcatttcct gcgttcgcgt catttccatc agatcaatgg caaggctgtt 2388361 catcgcatgt cctagcttat cagaacgcct aatatagccg ccgtacgtcc gtgcatcgta 2388421 gttgccctta gagagttctg tggctacatt tgtcgctgac tcaattgacc ttttataacg 2388481 tgaggtcatg ctggaataaa aataaacaat gacgataaat gcggtacaaa gactggccgt 2388541 cagcatcccc cacaattcgc cttttaagcc gtcgcttttt tcagaggcgg aaagcagcac 2388601 atatcctgtt ttttcacctt cgcttctaag tgaaagtccg taataaagct tgttatctgt 2388661 tgttgacaga ataccctcat ggccagaaac aagcgcctgc accttttggg aatcagccga 2388721 tctaccgttt gacccataca gcaccttacc gtctgtatcg ataacggatg cgctcacatc 2388781 aagcgcgccg cctgcatctt taatgatttt ctcatttgct tgattattca gattgccggc 2388841 atcaagaagc gaagccaagt attttgcttc tttttcaatg tgttcctctg ctttcctttg 2388901 atcagatgtt tcaaaaagct gctgtaaaaa cagcccgagg acacaaaaca ccagaatcat 2388961 acagacaacg aatacagaaa aaaggcgcac acggtattta ttcattcatt tttggctcct 2389021 ccagtttata ccccaatccc ctaatcgttt taatgtagat cggttttttg gtattgtttt 2389081 caattttgtc gcgaagatgg ctgatgtgca catcaacaat tctcgtatct ccggcaaaat 2389141 cataattcca gactgcgctc agcagcaggt ctcttgtcag aactctgcct ttatgtctgc 2389201 ctaaatagag cagcagttcg aattctttcg gtgtcagttc aagctgactt tctttaaagt 2389261 acgcttcata atgatcaggc aggattttca gatcgccgat tacgatctgg ccttccattt 2389321 catcgttctt catctcacta gagggcgcag ctatttccga acgccttaaa atcgctttga 2389381 ctctcgcatt tacttccctt ggactgaacg gcttggtcat ataatcatca gcaccgagct 2389441 ccagccctaa tactttgtcg aattcctcat ccttcgctgt cagcattaaa atgggaaaca 2389501 tcagtttttg ctgtctcagc tgcttgcata cttcgattcc gtccaatttt ggaagcatca 2389561 catcaagcac aatcaaatca ggtttctctg tttccgcttt tttgagtgct tcttccccat 2389621 ccgaggcggt aatgacatca tagcctgacc gttccaaatt gtactgtaaa agagtaacaa 2389681 tagattcttc atcatccaca actaaaattt tcttgttcat gctgtgcctc cagtattata 2389741 attccccgac atcctatttc tctattttat gtcatcttaa catgtttcat gattttattt 2389801 tagcgaaagc aggacattcc gacaattcgc cttttacatc atttttaaaa gaaataaaga 2389861 cgtttatgat agcgctttca tttatagtaa aaagagaaag gctgtattaa gcaagccttt 2389921 ctctcttttt attaggataa tactttcatg acatttttga cagattcaac tgatttattc 2389981 agctgcgctc tttcatagtc tgtcagttca agttcaatga tttgctcaag accgttgccg 2390041 cctacaattg taggaacacc aaggtagatg ccttcatagc cgtattcccc ttcaagataa 2390101 gcaattgtag gaaggacgcg gcgctgatct ttcaagatcg cttcgaccat ttctgtcaga 2390161 gaagccgcag gcgcataata cgcgcttccg tttccaagaa gattcacgat ttcgcctccg 2390221 ccttttctag tgcgctccac aattgcgtca atccgttctt tcggaataag agtttcaagc 2390281 gggataccgc cagcataaga ataacgcaca agcggaacca tatcgtcacc gtgtccgccg 2390341 agtacgaaac cagtcacatc tttcactgac aggtttaatt cctctgccac aaatgttctg 2390401 aatcttgccg tatcaagcac acctgactgg ccgattacac gctctttagg gaagcctgat 2390461 tctttgtaca ccgcgtatgt cattgcatca acaggatttg tcagcaccac aataatagag 2390521 tcaggagaat atttcacgat ttcctgcgta acgcttctca taatcttttc gtttgtagag 2390581 accagatcat ctctgctcat accaggtttt cttgcgatac cggctgtaat gacaacaatg 2390641 tcagagccgg ctgtatcctc gtaattggat gttcccgtaa tttttgcgtc aaagccttga 2390701 accgggcttg cttcaagcat atcaagcgct tttccctttg tcgggttctc caattgcgga 2390761 atgtcaacaa gaacaacgtc tgccagctct ttttgagcga ttaaaaatgc agttgtagct 2390821 ccggtaaaac ctgctccgat aacagaaact tttttacgag tatttcccat gtctctcttc 2390881 tcctttatgg ctagttttag gctttttcct tgcttagtcc atgtttttga tcagttcttc 2390941 tccgaactct gaacatttca cttcagtcgc cccgtccatt aatctggcaa aatcgtaagt 2391001 tacgacttta gaagcgattg ttttttccat agatttgata accaaatcag ccgcttcgtt 2391061 ccatcctaaa tgctcaagaa gcagaacgcc tgaaagaata actgaagatg ggtttacttt 2391121 atcaaggcct gcatatttag gagccgttcc gtgcgtcgcc tcgaaaatcg catgtcctgt 2391181 ttcgtagttg atgttcgctc caggagcaat gccgattccg ccgacttgcg cagcaagagc 2391241 atcagaaatg taatctccgt tcaagttcat tgtcgcaacg acatcaaact cgtttggacg 2391301 cgttaagatc tgctgaagga aaatgtcagc aatgctgtct ttgataatga tttttcctgc 2391361 tgcttccgct tcgctttgcg ctttgttggc agcgtctttt ccttgttctt cagcaatgcg 2391421 gtcatattga gcccatgtga agactttatc tccgtattct ttttcagcaa gttcatagcc 2391481 ccagtttttg aaggcgcctt ctgtgaactt catgatgttt cctttgtgaa caagtgttac 2391541 agatttgcgg ccatgctcga tcgcataatc aatggcagct ctgaccaagc ggcttgttcc 2391601 ttcttctgaa acaggcttaa tgccgatacc tgatgtctca gggaaacgga ttttattgac 2391661 gtttaactca ttttgaagga agctgataag cttttgcact tcttcagagc cttttgcata 2391721 ctcgatgcct gcgtaaatat cttctgtatt ttcacggaag atgaccatat cagtatcttc 2391781 agggcgtttt accggtgacg gcactccagt aaagtatctt acaggtctta agcagacgaa 2391841 taggtcaagc tcttgtctga gcgctacgtt caaagaacgg ataccgccgc cgacaggtgt 2391901 cgttaacggg cctttaatcg cgatgaaata ttcgcggatc acatctaatg tttcagcagg 2391961 gagccactca cctgttttat tataagcctt ttctccggcg taaacttctt tccatgtaat 2392021 tttcttttcg cctttgtatg ctttttctac tgctgcttcc aaaaccttcg aagccgcgtt 2392081 ccaaatatca ggaccggttc cgtctccttc gataaatggg ataatcgggt tgtttggtac 2392141 gtttaatact ccgttagaga ctgtaatttt ttcaccttgt gccacaataa aaacctccca 2392201 gtatgtaatt catatttaga aaacatttta tttttcttat atagaaaata aaatgatttt 2392261 tcctaacatt caatttaaag tgtaacccaa ttttgatgtc tgaacaagag gctaacctca 2392321 ttgacgcaag ccagcctcca atggttcttt aggctctttc ttcaatcgga acgaattttt 2392381 gtttgtcagg gcctgtgtaa tctgcccgcg ggcggatcag acggttgttg tcatactgct 2392441 caagaatatg agcgagccag ccggacattc tgcttacagc aaaaatcggt gtaaacaaat 2392501 catggtcaat accgaggctg tgatatacag aagccgaata gaaatcaacg ttaggcggaa 2392561 gctttttctc tgatgtgacg atgtcttcta tacgaatcga catctcatac catttgcttt 2392621 cgcctgtcag gttggtcagg cgcttgctca tttctttcag atgcttcgcg cgcggatcac 2392681 catgcttata cacacggtgg ccgaatccca tgattttttc tttcttttca agtttagcgc 2392741 ggatgtacgg ctcagcgttt tccacttcac cgatttctgt cagcattttc ataacgcctt 2392801 cattcgctcc gccgtgaaga ggccctttca gcgcgccgat tgctgcagta atgcctgaat 2392861 agatgtcaga aagtgttgcg acgcagaccc tcgctgtgaa cgttgacgcg ttcagctcat 2392921 ggtcagcatg taaaatcaat gctttgttga aggcttcaac ttcaattggt gaaggctctt 2392981 caccgtttaa tgtgtaaaga aaattctccg caataccgta atcttctctc ggttcaacag 2393041 gctcaagacc cttgcgaatt ctggaaaacg ctgcaaccag gccaggcacc tttgcctgaa 2393101 ggcggatcgc ctttctgtag ttggcttccg ggttcatggt atcagcctcg ctgtcaagca 2393161 ggcctagtaa tgaaattgct gtccgaagag cagccatggg atgaacattt tcgagggaat 2393221 aagatttgaa gtgctcaata atttcttgcg gaacggcagc ttcctttgca agctgctgct 2393281 ttaactcttc aagctctttt ttgtttggca gccttagatg ccaaagcaag tagatgattt 2393341 cttcaaaact tgcattctct gtcaaatcat cgatatcata ccccacatat gtaagggtat 2393401 catcaataat agaactaaca gatgatgttg ttgctacaac cccttcaaga ccgcgtgtcg 2393461 ctgtcatata taacatctcc ttttcaataa atttcccctt taagagtgtt gtaaaaacat 2393521 gaggcttact taaaaagcac gatgcaagta tttctctccc ccaaaaagaa aatgcttaca 2393581 ttttactggc tgctggaact aaaacccttt gcttttgaaa gaacataaca aatttttata 2393641 agcttattta agtttaagcc tattctcatt ataaacaata atcagacatt tgttaaatgt 2393701 ttacctataa tttttttttt ccattctgtg atttccccga aaaaacgcct ttatttgcgg 2393761 gtttttgcat aaaaaaaagc ggctttaagg ccgctttttt ttatgaagtg aacagtttta 2393821 cgatctgcat ggctaaataa gcaatccccg ctccgatcag cggccccacc gcaactcctc 2393881 caaaaagcgc gactgcaaga atggtcccga tcacgagagc agttgtaata tgcggatcat 2393941 tttcaagcag ggtcaggccg ttttttgcaa tcagcgccac tgcgatcccc gctccaaggg 2394001 cgatccatgc gtaggaagac cgcattgctt ctccaagctg cttaaatccg atttctcccg 2394061 tggcaatcgg gacaagaacg gcgatggtaa taatggtcac accccagtta atgccttttg 2394121 actggatggt cggaaataat ttctgatcaa gcccaacgat tttgatgatc aaaaggacgg 2394181 atacagcaaa gagcaatgat tggttttttg cgataagtgc gatagccaag agtaaaatta 2394241 aaaataaatt cgcttgtgta aacacatgcc atccctcctt taagatgaat gtattcatat 2394301 tcagccgcag cgtgaataca tataaaaaat aggacatgct gacgagagga ggaccgtttt 2394361 tgtgaatcaa tcttatatca ctattttttt cagaaccctc tttgtcatat caatgaccgc 2394421 agggtcgata gctgcggcct attattcgtt tccgttaact tatccgttcc tgatcgccct 2394481 tattctatct tcagtgattc atcctgttgt cgattatttg gacaaagtga caggattccc 2394541 ccgaacgata aatgttctgg gcgttcttgc tttttttctg ctcgcagcct tcggcgtgct 2394601 caccattctg gtagccgaaa tcgtaacggg aacagcctat ctagcaaaaa cgctgcctcc 2394661 gcatatcagc acgtttattt catattgcga aaaattgttt accactcata ttcagccgct 2394721 ctataacgag ttaactcttt tgtttcaaga attggaaacg aaccagcagg cttccatcgt 2394781 cactcatatc cagacactcg gtgattctgc cgctaaaaat gccgggctcc tgctgtccca 2394841 cattctagag atgatcccga gatttttcgc tcttcttccc aatacggcgg cggttctgat 2394901 tttttctctt ctggcaacct tttttatgac aaaggattgg cataagctga aagccatgct 2394961 tgttttaatt ctgccggatc gtgtgacagc taacagcaaa gcaatcagca gcgaattaaa 2395021 aaaagcaatg actggtttta tcaaagcaca agccgtcctc gttttcatca cgatggtgat 2395081 tgtatttatc ggcctttctc tcttaaaggt tgaacacgcc gcaacaattg cttttttaat 2395141 cgggcttgta gatcttctcc cttacttagg tgccggctcc gtatttgtgc cctggatttt 2395201 gtatttatcg attacgggcc agctgcccca agcaatcgga attggtatcc tgtacctcgt 2395261 cgttcttatt cagcggcagc tgacagagcc caagatacta agtaaatcta tcgggatcga 2395321 tccgctggca acactcatcg ccctgtttgc cggctttaaa ttattcgggt ttttaggact 2395381 gattgcggga ccggctgtac tcgtcatcat ccaagctttc atcacaacag gcgcattaaa 2395441 agaaatatgg tcctatatca ccgttcagca aaaataaaac ggcagccgtt ttttcatggc 2395501 tgccgttttt tatttgatga tgatccgctt attcttcgac attcctctca gccatttgaa 2395561 cagaatcggc ttacaccagc cgcgggtaaa cgggataaga agacaggcgc cggccaaatc 2395621 tgataaaaag cccggaagca tcagcaatag accgccaatg aaaatgcaca gaccgtcagc 2395681 aatcgcttct cccggcattt tgccatattg aagatcacgc tgaaccttat aatacacttc 2395741 ggttccttgt ttttttgcag ctgctgcgcc gataatgcca gtcagaatca tgaatagaac 2395801 tgtcggcaaa ataccaatca gatttcctaa aaataggaat ataccgattt ctattgccgg 2395861 aaacacaata aaaagcaaaa acaaaaatct catatccaag ccccccacac gtgtaacacg 2395921 ttctgttcaa caaaaggcat gataaagaga aaaggaaggg attccccttc cattttcacc 2395981 tgtaattaaa gaacgctcgc acggccttga tagactgcgc ctctggaagc gtcaactgta 2396041 atatcctggc catctgtcaa aatagatgtc gcattttcca gacccacgat aaccgggatg 2396101 ccaaggctta atccgactac cgcagcatgg ctagtcaaac cgccttcttc tgtaataaga 2396161 gcagacgctt tttcaaggga tgcaatcata tcacggtcag tgcttttggt aacaagtacc 2396221 gcaccgtcag tcattttttg ctcagcttct tttgcatttt gtgcaacgac aaccggaccg 2396281 taagctgatt tgcgtccaat gccttggcct ttagcgatga tatcgccgac agtatgaacc 2396341 ttcattaagt tcgtagtgcc ggactcaccg acagtgccag ctgtaataac gataagatcg 2396401 ccgtgtttta caattccgct gttcaatgat ttttggacag catcctcaag catctcatct 2396461 gttgagctcg cattttggcc gctttccgcg aatacgccag atacgagggc aagctttctg 2396521 gaaatagagt catttacagt aaccgcaaca atcggagcct gcggacggta ttttgcaatc 2396581 atacgtgctg tatggccgct ttctgtcggc gttacgatcg cagcagcatt caggttaatc 2396641 gccgtatgtg cgacagattg tccaattgcg tctgtaattg tcatgcccac ttggtctctg 2396701 cgttttgaga gaatttcttt ataatttaat gcttcttcag aacgggacgc gatgttatgc 2396761 attgtttgaa ctgcttcaac cgggtaactt ccggcagcag tttcaccaga aagcatgatc 2396821 gcatctgttc cgtcgaagat cgcgtttgca acgtcacttg cttccgcacg agtcggacgc 2396881 gggttgcgct gcatgctgtc aagcatttgt gtcgctgtaa taacaggttt gcccagcgcg 2396941 ttgcattttt tgatcagttc tttttgcaca agcggcactt cttcagctgg aatttccaca 2397001 cctaagtctc cgcgtgcaac cattaagccg tcagacactt cgagaatcgc atcgatgttg 2397061 tcaacgccct cttggttttc gattttaggg atgatttgaa tatcctgagc gttgtgctct 2397121 tcaagaagct cacggatttc gagcacatcc gtagaacgtc gaatgaaaga tggtgcgatg 2397181 aagtctactc cttgctcaat accgaaaacg atgtctcgcg catccttttc agtaatcccc 2397241 ggaagattga cacttacgcc cggtacgtta acaccttttt tatttttgag tgttccgttg 2397301 tttaatactt ttgttttgat ttcgcgttta gcggcatcta catcaagtac ctcaagaccg 2397361 ataaggccgt catctaacag aatcgttgaa ccttgttcaa cgtcatggac taaaccttca 2397421 tatgtcactg aaattttatc tgttgttcct acaacctcgt ccattgaaat aatgagctct 2397481 ttgcctgttt caagctcaat accgccgttt tccattgtat gtgtgcggat ttcaggacct 2397541 tttgtatcaa gcagaattcc aacgttcttg ccaagttttt tacttgcttc gcggatattt 2397601 ttaattcttg caccgtgctc ctcaaaatct ccgtgagaaa agtttaatcg agccacgttc 2397661 attcctgact ccattaattt cgtaagcatt tcaatacttt cacttgccgg accgatggta 2397721 caaacaattt tagtttttct catttggttc acttccttct gaaatcttca gccttcagct 2397781 gtacattaga tagacagttc ttttgaaagc tgatacatgt tttgctcaac tgtgtgtttt 2397841 gtctcaagta tttctataat atcatggtct acaagcttat tgttttgtat acctacacag 2397901 cgtccgcctt ttccttcaag cagcagttca actgcatatg cgccgagacg gcttgccaac 2397961 acacggtcag cagcactcgg agaacctccg cgctggatat ggcccaatac agatacccta 2398021 gtttcaagat ttgtttcttc ttcaatgcgt ttcccgaatt caacaccgct gcctacacct 2398081 tcggcaacaa taataatact gtgcttcttg ccgcgttcgt ggccgcgttt taagcgggca 2398141 atgatttcgt gcatgtcata gtctgcctca gggattaaga tcgattctgc gccccctgca 2398201 agaccggccc acaatgcgat atcgccggca tgacggccca ttacttcgat tacatatgta 2398261 cgttcatgag aagtcgctgt atcgcgaatc ttatcaattg cgtcaattac tgtatttaaa 2398321 gctgtatcga aaccgattgt aaaatcagtg cccggaatgt cattatcaat tgtacccggt 2398381 acacctacac atggaaaccc gtgttccgtt aattttttcg cacccatata ggaaccgtct 2398441 ccaccgataa caacaaggcc ttcaatacca agcttcttca agtttgctat ccctttttca 2398501 cggccttcaa ctgttttgaa ttcaggacat ctcgccgtat aaagcttagt ccctccacga 2398561 tgtataatat cgcctactga tccgagttca agcttttcaa tctttccgct gatcaatccc 2398621 gcgtatccgt tgtaaatacc gtaaacttca acgtcatgat agatcgcttt tctgactact 2398681 gcgcgaactg ctgcgttcat tcccggggaa tccccgccgc tcgttaatac ccctattcgt 2398741 ttcattctcc attcacctca gcaacatata tgattaaaca taacatgatc attgccctaa 2398801 aaacaatgaa aagggatctc catcctccct atgaaacctt acctattata caattaaata 2398861 aattgttttt aaataaaatt taaggaatgt cacaaaaaat aaacgtgagc caaaggcttc 2398921 acgtttattt agtttacccc gatatattga tcttcaaccg agactttgcc aattgcttta 2398981 tatttttcat aacgctgctg aactaattct tcttcgctca gcttcagtaa agtttttaac 2399041 gattgtttaa gggtttcgtc catatagctt gcctgcagct tcacatcatg gtgcgctccg 2399101 ccttttactt ctttaatcat atgatctata atacctaatt cttttaaatc cggcgcagtg 2399161 attttcattg tttctgctgc ttttttagca agactggagt ccttccataa aagtgccgcg 2399221 gcaccttccg gagaaataac agaataagta gagttttcca gcatatgcaa gtgattgcct 2399281 acacccagac caagggctcc gccgcttccg ccttcaccaa tgacgatgca gataacaggc 2399341 actcgaaggc cggccatctc aaacaggttt ttggcaatag cttcactttg tcctctttct 2399401 tcagctgctc gtccagggta tgcccccttc gtatcaataa aacagataat tggtctgtta 2399461 aatttgtcag cctgtttcat cagacgaagc gcttttctgt agccttctgg atgcggcatc 2399521 ccaaaattgc ggactaggtt ttccttcgtg tctttgccgc gctgatgccc gattaccgtt 2399581 acagggaggc cgtggaactt cgcaatcccg ccgacaatgg cttcatcgtc cccgtacgct 2399641 ctgtctccgt gacattcaaa aaagtcggta aacaggtgtt cgatataatc aagagttgtc 2399701 ggacggtccg ccagacgcgc gatttgaacc cggtcccacg gcttcaaatt tttgtaaata 2399761 tcatcctgaa gcttagcgag acggtcttcg agccgttcga tttccgcact tagatccata 2399821 tcggaatctt gggtgaattt ttttagttcg gcgattttgg tttgcagttc aatcaccggt 2399881 ttttcaaatt ctaatcttgg agccactcaa tgtcacctcc tgtttgatgc atatccagca 2399941 gattttctaa cgtttttttc atatcgtcgc gatgaataac cgcatcaagc tgtccatgtt 2400001 ttaataaaaa ctcagccgtt tggaagtcct caggcagttt ttctcctatt gtctgttcaa 2400061 taatccgtct tccggcaaaa ccgatcagcg cgccaggctc agcgaaattg taatcgccaa 2400121 gggatgcaaa gcttgctgat acgcccccgg tagtcggatg cgtcattact gaaataataa 2400181 gaccctgttc ttcactgaac agttttaacg cagagcttgt ctttgccatc tgcatcaaac 2400241 ttaatacgcc ttcctgcatt ctagcaccgc ctgaagccgt aaaaataata aacggaactt 2400301 tatcagcttt tgctttttca atcgcaagcg tgattttttc accgacgact gaacccatgc 2400361 tgcccattct gaatgaagag tccatgacgg cgacaacagc cgggtgtccg ccgatggtgc 2400421 ccttgcctgt cacaacagcc tcgtttaagg atgttttctc gcgatctttt tcaagctttt 2400481 ccagatatcc cgggaaacca agcggatttt ccgagagcat tccctgatta aattcctcaa 2400541 aggattgttc atccatcaag ctttcgatac gctgttttgc gttcattggg aaatgataat 2400601 cgcagttcat gcatacccgc atatttttat ccaactcttt agtgagcatg atttttttac 2400661 acttaggaca ttttgtcata atgccttccg gaacatcgtg cttcgcttga tcagacggta 2400721 cggaagcata ctttttcttt ttcgtgaata tatcctttaa caaatgatta cctccctttt 2400781 gtgaagggtt ctcttcaccg catgtcatca aacagataga cttgctaata actttaccga 2400841 aactattgta ctttttttgt caaacgctgt catcctcaat tcgacaactt tttattcgat 2400901 gacgtgctcg gaaaggcttg tatgaaatca gataaggtgt tgaaacgaca aggttgacag 2400961 cgcattcaaa aataatgtta aacccggctg aaattttttt aaggctaacc ccctaaaaaa 2401021 atttcagccg tcagtttaac ttgagaacag cgcgccggtc tccgccaacg cgctgccatt 2401081 tttggaatga attaaaatta ttcaccaata atcgtaagtt ttcttgtttt ttctgcgact 2401141 tcctcagggt caacagtgat tcttgcaaca cctgtttcca tcgcagcttt tgccacagcc 2401201 ttcgcaacag caggcgcaac acgtttatca aacggtgcag ggatgacata gtctgcgcta 2401261 agctcatctt ctgaaaccag tgaagcaatg gcttcaaccg ctgcgatttt catttcctcg 2401321 ttaatatgag tggcacgcac atcaagcgct ccgcggaaaa taccagggaa tgcaagaaca 2401381 ttgtttactt ggttcgggaa gtcagaacgg ccagttccga caacgcttgc tccggcttca 2401441 cgcgcatctt ccggcatgat ttccggattt ggatttgcca ttgcaaagat aatcggatct 2401501 tttgccatgc tttgaaccat ttcttttgtt aacgcgcctg ctacagagac accgataaat 2401561 acgtcagcat caacgataac atctttcaga gaaccgtctt tgcgatcttg gttcgtgaac 2401621 ttcgccactt catttttgac atcgttcatg ccgttcgggc gcccttcata aatggcccct 2401681 ttggaatcgc acatcacaat gtcgcgaacg ccataatgat gaagaagctt gataatcgca 2401741 atgccagccg cacccgcgcc gtttgcgaca actttaatgg atgacatgga ttttccagac 2401801 agtttcagcg cgttcacaag acctgctacg gttacaatgg cagtaccgtg ctgatcatca 2401861 tggaaaaccg ggatgtttgt ttcttttttg aggcgctctt caatgataaa gcagtttggc 2401921 gctgcaatat cttcaaggtt gacgccgcca aatgtcggtt ccagcaattt tacagtttca 2401981 acgattttat caacatcgtt tgtgtttaaa gcaatcggga acgcatctac gcccgcaaag 2402041 cttttgaaaa gaactgcttt cccttccata acaggaagcg ccgcttcagg gccgatgttt 2402101 ccaaggccaa gcacagctgt accgtcagtt acaactgcta ccatgttccc cttcattgta 2402161 taatcatata ctttgttaat gtcttcatga atatccttac acggttctgc aacacccgga 2402221 gaatacgcga ggcttaaatc tttcgcattt ctgacctcta cttttgattt agactccagt 2402281 ttcccctggt tgactttatg caggtgtaat gcttcttctc ttaatgacat tctcctaaac 2402341 actccttatg gatatttttt gattcgtata ctgctgcgtt gattgctgca ttctgcggag 2402401 taaatctatc tgaatattta aacaggatca cataattgct ccaattgtat aacaaaaagc 2402461 gaatcgttac cactgtttta aaacgacgtt tttttgaccc aacagctctt ttaagcgata 2402521 taacacctgg tgatctgcat tgatatggaa cgactcaggt agcttaatcg tctgtttttg 2402581 cctttcataa tagagataaa cgcctgtttc ccctttatgc tccagcaaaa tgcgcttaat 2402641 ctttgccagg atctcctggc tgtgctgact gctttctatt tttatataaa ccgatggcgc 2402701 tttttctgca tccatatctt ctaataattc tgcccgggac atgatgaatt ggatcttatc 2402761 ttgtctaact tcacatttcc ccgcagtgaa caaaagagcg ccttctctta aaacgggaga 2402821 aagctgtctg aattgttcag ggaagactac ggcttccatc tcgccggttt catcactgag 2402881 cgttaaaaac gccatgtttt gacctgtttt cgtccgaatc gttttgatct tcgacagcag 2402941 aacgcctagt gaaagctgcc ttttgactgc ccgctgagcc tgcagaatgg agactgctcc 2403001 ttgcgcagtg agctgttttc ggaaggcgga gaggggatga tttgaaaaat aaatgccaag 2403061 cgtttccttt tcaaacgcaa gtaaatccac cagaggaagc tcctccgtct ccacatactt 2403121 cggcttaatt gaaaacgatt catctaaaaa caatcccatt tggtcatcgt ccgcggcgaa 2403181 tagctcagca tgttccaaag caacatcaat ggatgcgagc agcgtggccc ggttttggcc 2403241 gaattcgtcc atcgcaccag aaaagataag tgcttcaagc attttgcgat ttacgctttt 2403301 tgacggcacg cgaaagcaga aatcgaaaag atcttcaaat ggtttctctt ttcttgcttt 2403361 atatatatct ttgactgctg agacgcctac actttttatc gcgcggaggc tgtatctgac 2403421 agatccgttt tcaactgtaa acggaaaact gcttttattc actgacggag gaaggatacg 2403481 aatcccgctc ccctttgctt cgtaaagata ttgagagatt ttatcctcat tgccaatgac 2403541 gcttgtcagc aatccgcaca taaaatataa cggataatga gctttcaaat acgcaagctg 2403601 gcacccgatc atgctgtatg ccaccgcatg gcttctgtta aagccatagt ttgcgaattt 2403661 gacgattaaa tcgtagacct catttgcagt gtctacagaa tactcctttt ttaagcaccc 2403721 ttcaacaaaa tggcttcgct ctctgtccag gatttctttt ttctttttgc tgaccgccct 2403781 tctcaatagg tccgcttcgc ctaaagaaaa ccccgccata cgggaagcaa tcatcataat 2403841 ttgttcctga tacacaatga cgccatatgt atcttccaaa atgctcctta aatcttcatg 2403901 aggatagtga acaggcgccc gaccgtgttt acggtcgata aataacggaa tattttccat 2403961 cggacccggc cggtacagtg cattgaccgc cacaatatct tctaggcccg aaggtttcag 2404021 ccgtttcaag acgcttctca tccctgcaga ttcaagctgg aaaatgcctg tcgtatcccc 2404081 ttttgacagc aaggagaacg ttttgtcatc gctgtaggaa atacttgaaa ggtctatttt 2404141 aatattttct tctttttcaa tcattgaagt gatggattca ataagtgtca gattcctcaa 2404201 acctaagaaa tccattttta aaaggcccaa gtcttcaaga tggtccatcg cgtattgcgt 2404261 taaatagatc ccttcatgcc cttcttgaag cggaacaaca tctgttaacg gttcttcact 2404321 caggacaacg cccgctgcgt gggttgatgc atgccttggc agcccttcta ttttccgggc 2404381 aattgaatag acttgctgaa gcaggcttga ctcccgaagc cgcttatcca gctgcggtga 2404441 ctgctgtctc gcttcatcca gcgtcattcc cggtcttgaa ggaatgagtt ttgcaagctg 2404501 atctgcctcc ttcgggctga cgccgaatac tctgccgacg tcccggagcg ccgcctttgc 2404561 cgcaagtgtt ccaaaggtga taatctgtgc gacgtgcatt gcaccgtatt tctgctgaac 2404621 atattgaatg acttcatccc ttctagtatc gggaaagtca atatcaatat ccggcatgct 2404681 gacgcgttcg ggatttaaaa atctttcaaa cagaaggtga tgcttaatcg ggtcaacatc 2404741 tgtgatatac agcacatatg ccacaagaga acccgccgca gaaccccttc ccggtcctgt 2404801 aacaatccct ttttcatggg cgtgcttcat aaaatcccac acgatcagaa agtaatcgct 2404861 gaacttcatc cgcttgatga catcaagctc atattgaaga cggcgaaggt atcgttcatc 2404921 aggcttgccg aaacggctgc ggagtccctc catacagata tccgttaaat aatcatcagc 2404981 ggacgttccg tctggggtcg gaaaagacgg tagacgggtc tgcccgagac tgacgtcaac 2405041 ccggcattgt tccgcgatct ctacagaagc ttgcagtgcc tcgggatgct ctcgataaat 2405101 gttttgcatt tcttcgagtg gtttcaaatc gagatcaggc aaatcttcag cgggtgcatc 2405161 cgtcagtttt tcccccgctt taatcgcttt caaacaacgg taggcagcct tatcttcctt 2405221 ccttatgtaa tgcacatcgc ctgtggccgt aacagggata cccgtttctt ctgacagctt 2405281 tagaatctgc tcagacaaga cttgattccc tttaaaaggc tgataggaga aataaaaagc 2405341 tccctttccg aatatagact gaaattccag cgaggcttga gcagcctgtt cgaacagccc 2405401 tccttcaaga agcgtttcaa tatatccttt ttcgccgggc gttattgcga taatcccttc 2405461 tcgataactg tgaagccatt tcggcttcag tccgcctttt gatttagatt gcagaacgct 2405521 gctgattttc agcaggtttt gatagcctgt attcgatttt gccagcagga cgagcgggta 2405581 tgcttcaagc tcgctgtcat ctgtaaaaac agaagccgtc aaaccgatta ttgggttgat 2405641 ccctctcgcc ttgcaagctt tataaaattg aatagctccg tacatgacat gatcatctgt 2405701 cagcgccaaa gacgcatatc cgagcctgtc agcttcactg acgagttctt ccacagccgc 2405761 ggcgctgttt agcaggctat acccgctatg cacttgcagg tgaacaaaag acatgctatc 2405821 acctctttct cattacgatc catttcttcc ttcattataa ggccggtttc caaaagaaac 2405881 aaatgttctt ttttgactca tcatcatact tgtcctgaaa gctcaatatg atataaaagg 2405941 tgaggtgata aagatggatc aggaagcagg atttatggtg aattttatca atagctactt 2406001 cattgcgtta ggggtgctga tcgggggcgc actcatcgga gggctcggag catacttggc 2406061 aggcgaaccc ccgcttacag ccattacaaa gcttgccaac cggttaaaaa tatgggcgct 2406121 tgtcgcagct atcggaggca cctttgatgc ggtatacagc tttgaacgcg gcatactcga 2406181 aggcaatacg agagatatct ttaaacagct tcttttaatt atttcggcca tggggggcgc 2406241 gcaaagcggc tggcttatta tatcatggct gacccaggag catctttctt catgagggtc 2406301 ccccagcatt acaaaaaacc gggatggcag cgttttttcg cgggaatgat gtgcggagcc 2406361 gtaatcagct ggttcttttt cctgtttact tacggaacat tccaagagga gcaggtcagc 2406421 ctcatcgaaa agcaaaaaga gcatgtaaaa gacttgaaca atcaaatttc gatctatcag 2406481 gaagacctcc ataaactgaa tgaagataat aaaagaaaac tgctgattca aagcgtcagc 2406541 gtcaaattgc tgaatgggga taaatataaa atatcacagc cggataaaac gaaattcgag 2406601 gagcatgtaa aggatgatat ttcagaggtg attacaaaag acatagagag cgtctatcaa 2406661 acaaaggatc tcttgaagcg gacaattgaa aataaagtct atatgatcaa tgaaaaaaaa 2406721 tacgaggcaa ccgtcagaga attgattatt tatacgaggc tgacagtgga acttgaaatt 2406781 tctttcgcca cataattatg gatttttttt aaattctcca aacttctgtc gctttttccc 2406841 attctttttt ataaactata tgtgaggctt aatggcgaaa ggaaggagga agggaaatgg 2406901 aggtttacag tgaccgtcag ttagcaaaag atcaagcagc ccgtctcaga caaggttttt 2406961 ctgcatatgc cgaaacaaac tcactcgctt ccctcatcaa aaaagaactt caatcacaca 2407021 atctccaagt ctacgaggac cttactgatt tcggctgctg gttcatcccc gtcacagatg 2407081 aacactaaga gagagggtct cccctctact cgtgttcttt acataatgtt tccagatcag 2407141 ctaaaatacg atcagcttca tcccagctgt aaatagaggc gcctgaagct aacggatgcc 2407201 ctccgccgtt atatttccgg gcaagtccgt taatgacagg ccccttcgaa cggaatctga 2407261 ctctgatttg atcgtcttct tctacgaaaa acacccaggc gcgaatacct gagatattgc 2407321 caagcgtccc gacaagctgc gacgcttcag aagccgttgt gccgaatttt tcaagcgtat 2407381 cctttttgat gaaaacagaa gccgccccgt tttcggacaa agacacattt tgaaagataa 2407441 agccgttaag cttcaccaca ttcagttttg tttcatacaa ttgattaaat aactctgagg 2407501 aagagaatgg atactgaatg agctcgcctg catattttag tgttttttcc gtggtattcg 2407561 gaaataaaaa gcgtccggta tctccaacaa tgccggcgta gatcagctct gccgctttcg 2407621 tattcagctt ccagccgtgc tcttttcctt ctaaatacag ctcgtaaatc atttcactta 2407681 ctgagctggc gcttgtatcg acccagagaa ggtcaccgta tggatcttcg ttcggatggt 2407741 ggtcgatttt cattagtttg gcgcctgaag gataacgctg atcgtcgatt ctttcctgat 2407801 ttgccgtatc gcagacaatg acaagtgcgc cttcatatgt ttcattgtcc acctcatcaa 2407861 gggaatataa gaaagagagg gacggttcag gcgtgccgac cgcaaaaata tttttttcag 2407921 gatatgtttc acgcaggatt tccgtaagcc cacactgtga tccgtaggca tccggatcag 2407981 gacgcacatg tctatgtaag ataatcgtgt catataatga tatggttctg atcaattctg 2408041 ttttcatttg atactccttt attgttttta ttcattaaat cacattctct gccgacggaa 2408101 aagaaaaata acgtcaaaac caagcccgtt tttgtataaa atggggttgt aaacttttac 2408161 gatggaggat ttcatttatg ctggttcttg tttttttgat tgggctttca gcctgctttt 2408221 atgtgtacta taaagtaaaa ggcgtacggg caaagccatc tttggcaaaa gaaatatgtt 2408281 cagcaaaatc aagcatggcc ttagggtcac tagtcctgtt ctacgggctt aaccaaatga 2408341 tattattcca ttcagtatta acgttagtaa tcggcggtat ctttatcgtc ataggagcag 2408401 gaagcgcttg ggcaggttat aaagccttca ggcattacaa tccccttcac gccaaagaag 2408461 ctgaaagaga tcacgcgtaa ggggcgcctg aacgtccctt agcttctttc catcagctga 2408521 accatcagca tcgctttaga cacgatatga ccttggctgt gcacttccac ttccattttc 2408581 ccaaactttc tgccggcctc caagatgcga ggtttgactt cgatgactga ttccatctgc 2408641 acaggcttca aaaagaagat ggtgatgctc tctatgacga gttcgccgcg ttttttcgag 2408701 cgcaaaaatc ggtttgccgc ttgcgtcaaa atggtcgtaa atacgccata agaaatggtt 2408761 ccaagctgat ttgtcatttg cggcgtgact tcatactcgt aaaccgtttg atcttcttta 2408821 tcatcaccct catctttaaa cccccttgaa acgatatcat caagcttctc cccgacctgc 2408881 ggctgctttt gaatcatttg aagagctttc aatacgtctt ggcggctgat catgccgatg 2408941 agtttttggt ggccgtcagt gacgggaagc acttcgatcc cttcccatac catcatttgc 2409001 gcagctgaag cgacagatgt tttcccaata accgtgacgg gatttttggt catgactttt 2409061 tctatagatg catttcggtc atggccagca atatcttttg atgtcagaat gccatggatt 2409121 ttcatttgat cgtcgacaac cgggaagcgg ccgtgccccg tttcaaaatt tttctcatac 2409181 catttttcaa gtttatcctt aggcgaaaga tataccgtgc ggtcagcagg tgttaggatg 2409241 tcctccacca aaacaatttc ttttttgatc agctggtcat atattgcccg gttaatcatc 2409301 gcggcaactg taaaggtgtc atagctcgtg gataaaatcg gcagttcaag ctcatctgcc 2409361 agctgcacaa tgctgtcatc cgtgttaaag cccccggtca ccaatacggc cgcgcccgct 2409421 tcaagcgcct gcctgtgtgc attgattctg tttccgacaa tcaaaagatt ccccgctgcg 2409481 gtgtaacgca tcatcgcgtc aagctccatc gcgccgatga cgaatttatt caatgtctta 2409541 tggagccctg ccctgcctcc gagcacttgt ccgtctataa catttacaac ctctgcatag 2409601 gtaagctttt caatgttctc ttttttcttt tgttcaattc tgattgtgcc cacacgttca 2409661 atcgtgctga caaacccttt attctctgct tccttgatcg ctctgtacgc ggttccttcg 2409721 cttactttca tttcctttgc aattcttcgg acagaaattt tttcaccgac aggcagtgaa 2409781 tcgatatacg ttaaaatttg ttcatgcttc gttgccaagc ctttcacctc taaggacagt 2409841 cttcttgttt ttattataag gtttcaaagg atttatacgc aatgaggctg gaaaataaaa 2409901 aagaagcccg accggcttct tacagcgttg atttcgttcc agtcaaacgc aaggaccacg 2409961 tgattccttt tacatcgtaa agcggaaaaa cctttatttt tcttttaaat ggacatcaac 2410021 cgctgtctta acaatatttc gattccctat tttagataaa acaaataaaa ctgcggatag 2410081 ccatatcgcc cctatggccg tatagatcaa tggatgaaca gctgtgtttg cgatccattc 2410141 atttattaat gttctggcat ttaccagaat aataaatcct cctacaagca cacccatcaa 2410201 ttgcggatga aacttctgca ccagccatgc tgcgataggg gcagcgataa ttccgccggc 2410261 cattagtgaa aacacccata accaattgac gtcctcccat cctaatgaaa taagaaaacc 2410321 ggcggttgca gatacggcga tggcaaattc acttgtgtct acagtcccga caactttcct 2410381 cgggctcaag cctttgcggg ataataaaat cggagtggtc accggtcccc agccgcctcc 2410441 gcctgtggca tctgcaaaac cagcgatcac tcccaatggg atggattgtt ttcggtttaa 2410501 cggcacatgc ttcttctcaa gagccggctt atattgaaat aaaaacctga tcaatacata 2410561 tccgcccaga aggagcaaaa acaaagaaat atagggtttc gccacatctc caggtaattg 2410621 gctgaggaat gccgcgccta aaaaagcgcc tatagagccg ggaatgacaa gctgataaac 2410681 ggtttgtttg tcaacattgc caaatttaat atgcgacact cccgatgcgg cagtcgttac 2410741 gacttccgct aaatggacag aagccgaagc cacagcaggt gtgatgccaa acgccaataa 2410801 caaagaagtt gaggtaaccc cataagccat acctaacgaa ccgtctatta actgcgacaa 2410861 taaaccaata aatgcaaaaa cgattaattt cttcatcaga acaccccatc tatatcaatc 2410921 agatattttt gactcttcat tcgaatctaa caatctcttg gcgctttcat ataaaaaata 2410981 agaggctttg ataattgcag tttcatctat tgtaaatgca gggtggtgcc aatcatgatc 2411041 accgtctgtt ccaaaaaacg caaaggatcc cggaatatgc tcaagataat aagcaaaatc 2411101 ttcccccgcg gttgatgggg cgggatcaat gacttgaagt ttcgctttat gtgcagcgtc 2411161 tcgcaccagc cccgtaattg cctcatcatt acaaagcggc ggcggtccgg aatgccactt 2411221 cacatttgcc tttaacgaga aagcggcaga aatctgctct gtgactgcaa aaaaacgctg 2411281 tttcacttga ttacgaacct ctgaatcaaa tgtacgaaca gtgccctcaa tgaccactgt 2411341 atccggaatg acattccaag tgctgccgcc gttgattttc cctacggtta aaatcgcgct 2411401 ttgcagcggg tttacatttc tgcttacaat cgtttgcagg gcgacaataa gctgagaggc 2411461 gccgataatt ggatcaaaac cattatgcgg caatgctgca tgagcacctt tcccttctat 2411521 ctctacttta aatcggtcaa cagcagccat aagcgggcct gtttttaacc ctacagtccc 2411581 aaccgcgata tccggtttat tgtgaaggcc aataaccgca tcaatgccat ccagttggcc 2411641 gtcctctatc acttttgtag cgcctgcacc cgcttcctct gctggctgaa ataataaacg 2411701 aatctttcct ttcagactgt cttgattttc cttcaataaa aaggccgcac caagaagcgc 2411761 tgccgtatga aaatcatgac cgcacgcatg catgatccct ttatgtttag acgcataagg 2411821 caatcctgtt ttttcttcaa ttggcaaggc gtcaatatca gccctcaaag caatcgccgg 2411881 accttctgac tcccctgcta tgtctgcgaa cacacccgtt tttagagcag tagggcgaat 2411941 ctgtatcccc ttttctttaa ggcatttttt tataaaagca gttgtttcaa attcttcttt 2412001 tgacagttca ggatattggt gcaggtgccg gcgaatgccg atgagctgct tttctagcgt 2412061 tgagagattt acgggattag actcctcttt caacgtcagg atgtcatttc ctgtagtctg 2412121 atatggatag gagccttcta tatttctcca ataatccaaa gacatatgtt ccgctccttt 2412181 ccctatccca atatattttc ttcagactct tcaacataag atgaaataaa tcggttcaat 2412241 ttatcagcaa gaccgcccgc cccaaatctt atatacttgc tggaaacttt cggattatct 2412301 tctttcaaaa agcttaaaaa agataaaata taaatgcgcc tgtaagctac ttgtgtaatt 2412361 ccgtactcaa aaaaccagtt atcaatgaca ttgtatacgc ctcggttgac gccatatagg 2412421 ttattacatt tcttgtaaaa gcagagatcc ggaagattta actcctgatg ggaaagaagg 2412481 ctttcttttt tgtttggtgc cataatccca atcagctcaa agcgttttgc aacgcacgaa 2412541 atatcctttt taatttgctt tgttaaagac tccaaagaat caaaccttct ttcttctcta 2412601 attttaaaga gaatgctgca ttcgattttt tctccataaa tgtctctatg aaagtcaaac 2412661 aaaaaaatct ccaatgtctt ttcaaggtta gagcccaccg tcggtttcac accgatattc 2412721 ataaccccta aatgaaattg atgattgact gtcgccagaa ccccataaac tccattacgc 2412781 agcccatgta tttttgcatc tacatttgcc gtggggaatc caagctttct gcctaattgt 2412841 tttcctttca caaccgtacc ggcaatgatc gtcaaaaaag tcagcctcct ctctcagctt 2412901 ccgcattcga tcagacgaaa cctaatgatg tgatgaatgt aaaacggatt gatgctgcgg 2412961 aatgccaaga ccgagatttt cccgcaatgt cccgccgcga taatcttgac gataaagccc 2413021 tctttcttga agaatcggaa tcaccttttc tacaaaagca tcaagtgttc ccggtatatc 2413081 cgacccaacg ataaacccat ccgccgcctc agcgttgaac caagtttcaa ttaaggatgc 2413141 gacacgctct ggtgttccga tgaatagagt ccgtggaaaa gccatttcct gtgctacctc 2413201 ccgcaatgtc agatttctgg cttttgcttc tctcttaatc cggtctgttg tgctttgaaa 2413261 cgcattcttt cccacatcgc caatatcggg aaatggctca tccaacgggt aaacactcag 2413321 atcataatca tcaaaaaaac gggccaaata agtaacagca ttttcaatcg gtatcaattc 2413381 tgcaaattca cgatacttct tttccgcctc ttcttccgta tctgccacaa tcgggctgat 2413441 ccctggaaaa atccgcacac ttgaaggatc acgcccttca tcagcagctc ggcttttcac 2413501 atccgcataa aacgcttttg tctcttctaa tgaattggaa tgggtaaaaa tcgcatccgc 2413561 atttttagca gcaaactgcc ggcctgtttc tgatgaaccc gcttgaaaca ctacaggctc 2413621 tccctgctta gagcgcccga tattcaaggg cccctctact tgaaaatact ttcctttatg 2413681 attcaggcga tgaagcttcg cctgatcgaa aaactgccct gttttcttat tgtgtataaa 2413741 tgcgtcatgc tcccaggaat tccacagccc gcgcacaaca tccaaatgct cttgtgcgat 2413801 ctcgtaacgt tcagtgtgtt ctggcaaatt agacttacta tggttgcgcg ccgctccttc 2413861 ctgcggcgaa gtaaccagat tccagccggc cctgcccccg ctgatatggt ccagcgacat 2413921 caattgtctg gagatagtga atggctcagt aaaagatgta gagaacgtcc ctactaaacc 2413981 aatatttttg gtaaccgatg ccagcgcaga taaaatggtg atcggttcaa aacggtttaa 2414041 aaaatgagga atcgattttt cagaaataaa taagccgtct gcaatgaaaa taaaactaaa 2414101 caaacctttt tcagctgttt gcgccttttt catgtaaaat tcaatattcg tgctggccga 2414161 gggatcaaca tcgggatgac gccagccgtc agttgttccc ccgacaccgt gaatcatggc 2414221 tccaaactga ataaaatctg cacgtgtcat ctttttgcct cctttatctg tgcatgatta 2414281 gcaagtgcaa gatcaaggtg ttcaatgccg atttcagtta tcccttgata ctgattgccg 2414341 cgcccgattt cgaccacagg cacatggcgc accccatatt tcacctgtaa aatatcccga 2414401 agcttttctt tctctgaaac atcgatattt tggaacggga accctttttc attcaaataa 2414461 ttcttgactt cctcacaata cgaacagcct tttttactcc aaaccacaat gttcacaaca 2414521 tcactcattc ttctgtccct ccttaacgtt ttgcagctaa aactgcatcg ctcagcagct 2414581 gataagacag ctgtttttct acagcatttt tgatcggtgt aaaaataaca aaatcattga 2414641 ttttgtatgt gcctgataaa cgtgttaatt cttctgccac ttcttccttt gttccggcaa 2414701 taatcccggt tttttgcacg atgatgtcat agggctctgt gacgttttcc agataggcct 2414761 cagcctgttc gcgggaaccg acgttgacct tacgcccgtc tttcaaaacc acttttatcg 2414821 attcacgcga cacaatatgt ttttccgctt cttcttttgt atgtgccgca aaaacagcgg 2414881 gggcaagatg aaattcagcc tcagatcctg gcgggagatg cgcgtcaaat gctcggcggg 2414941 cttccttcag cacttcctct tcaccgttaa taaagtaagc aaagacaaaa gagattccca 2415001 gttttgcagc agaaatggca ctctctgtgc ttcctcccaa tagaaaaata cccggcttcc 2415061 gatcaacctg cggcctagga cgcaatgcgg catagcggtg ggtatcagga aaatcatccc 2415121 gaacgaaatg agtaagctcc tccagttttt catcaaactg acgcaccggt tttttatatt 2415181 cggcctgcag cgcgtctgtg gacagctgaa acccgccggg cgctttgccc actccaagat 2415241 ctatacggcc gggagctaac gctgatagaa gatggaattg ctccgctact ttataagagc 2415301 tgtaatgctg cagcatcact ccgcctgatg ctaaacgaat ttttcttgtg cttgcagcaa 2415361 gatagcctaa aagaacctcg ggtgcagacc ctgcaatctc atcattgttg tgatgttcgg 2415421 ccacccaaaa tcggtgatat ccacattctt cagccatttg tgccaatttc actgtatgct 2415481 gtaatgtatc agctgctgtc tccccttcac caatcaagct ttggtctaaa atacttaagc 2415541 ggatcatatc accggctcct ttatgtgttc ttttggttca aataaatatt ccggcgaaac 2415601 acggcggaga aactgcctcg ttctgtcttt tttggtatgg cggaagactt cctccggggt 2415661 tccttgttca acaatgactc cttcatccat aaaaacaact tgatcagaga cccttcttgc 2415721 aaactccatt tcatgtgtaa caacaatcat ggtggctccg gttttcacga tttccagcat 2415781 tacctcaagc acttcaccga ccagctccgg gtcaagcgct gccgtcggct catcgaacag 2415841 cagcacatca ggatgaatgg caagcgccct tgctatccct accctctgct tttgtcctcc 2415901 cgataactga ctcggataag cgttcaattt atcttgaagc ccgacctttc tcagttcatt 2415961 ttccgctacg gcatacgcgt cttgttttct cattttccgg gcaatcgtca agccctccat 2416021 gacattttca atcaccgttt tgtgagcaaa caggtggtat tgctgaaata ccattgccgt 2416081 ctgttttctg agccagtgaa cctctttttt ggacggaaag cggcaattaa tcactttgtc 2416141 atgtatagaa atgatccctt cgtctggacg ttctaataaa ttcaggcacc gtaaaaaggt 2416201 ggttttccct gatccgctcg gcccgataat cgtcacaact tctcccttgc gtaccgtgag 2416261 atttatccct tttaatacat ggtggatgcc aaactgttta tggatatttt taatctcaat 2416321 cataaagtgc ctccttgaaa tctggctgcc tttctctcta atactccatt tgcggattct 2416381 aggattagag tcagcaccca atagataatc gctgctccga taaacgcttc taaaaatgca 2416441 taattatcag aagcaacgat agtcgccgtc cctgtaatct ctgggacagc cactatagcc 2416501 gcgatagagg tggtatgcaa aaagccgata cccaaatttg tgaagtttgg gatggaaacc 2416561 ttcagcgcct gcggcaatat tacacgccga aaggtttggc tgtatgtcaa gccgattgaa 2416621 taagccgctt cgacctgtcc ggtatccatc gccagaatgc ccgaccggat gatttctgtg 2416681 agataagctc cggcagttaa agacaaggcc atgatgacaa acatggagac cggtatctca 2416741 ttagcggacc agccgagatg aaaaaaactg ctgacttgat ctgcaacagg cggtatccct 2416801 aaataaatca acataatgtg aagaattgca ggtgtacttc gaaagaaaga cacataaaac 2416861 cttgagcaag ccaccaagcc cttaattcta aaaattctaa caattatatt tccaagagcc 2416921 acgagaaatc caaacacaat cggcaaaaca gccatcatca atgtcagagg aatggtcttt 2416981 accatttctt tcatggcgga aacgataaat ggaaagtcaa attgcaatct tctcccccct 2417041 catccgaaga aatatatcaa tgtatgttca tgtcaaaaac agtaacaatc cttgtttgat 2417101 tcttcttgat tcgtttttct gccactcgaa agaaccattc gaataaaacc gctacagcat 2417161 aataaacaat cgatagcgca atgtaaactt caagagaatg gttgcttgag gtaatcagtg 2417221 tttggcccct tccggacata tccataacac ctattgaaaa ggctagagac gtatctttta 2417281 aagaactgat caccatgttt cccatattcg gaaacgcctg gacaagtgcc tggggcagaa 2417341 cgattcgcct gaaggcctga ctaccgctta agccaatact gtacgccgct tccgtttggc 2417401 ctttatctac actgcccacc cccgctcgaa tgatttctgc ggctgccgct gcattgctta 2417461 acgcgtaggt tgcgacagca gcataaaacg ggtccatttt tgatgtatca atcccgataa 2417521 gccccgtaag cgccgggatc ccgtaaaaca cgatgaaaag ctgcaccatg ataggcgttc 2417581 ccctgaaaaa cgagatatac acttttgcca attgatttac aattggaata ttatagatgc 2417641 ggggcagtgc cagaaagagt cctaatacaa aaccgaaaag caaggacagt gttaaaatgt 2417701 ataatgtaac cggtaaataa gcggttaacg tcggcacaaa atctccaatc atgttcatat 2417761 caaacgcttt ttccatcact gctccctctc tttttaccta atactgctct ttggaatagt 2417821 cgtcaccaag ccatttcaaa ctgagccttt tcaacgttcc gtcatcaatg atttcctgta 2417881 aggctttatc aatatcgtca cttaacgttt gttcattttt gttaaacata aaatacactt 2417941 tggcatttga aagcacatta ccgacggttt tttctttaat agtgctcgtc ttgttttgaa 2418001 agtctactgc aaaaggcgtt gagatcgttg cgtccgcacg ccccgatttc agctgattcg 2418061 cagtctcatt tgcgccttgg ccctcatagg caatctcaaa cggccgtcca ttatcctcat 2418121 tccatttttt cagtacaagc gctccgttgg aggttgcact cgtaatcacc cgttttcctt 2418181 ttaagtcttc aattccacgg atcgtatcgt tattttgaag cacagtaatt tttaaaggaa 2418241 aatggttgta agcaaccttg ttaaacagaa attttttctc acgctctttg cttttctcca 2418301 tttgatgtgc cacgatatcg actttatgct gtccgaggct gacaagcagg ttggaaaatt 2418361 ccatcgtttt aaatgtgaat ttataatgtg gcaggcgctt atcaagctct ttgatcagtt 2418421 cgacatcata accggttaaa tcgccttttt catcgataaa gcaaatattc ggaaattggg 2418481 ttccagttcc gaccgtgatc gtctgtacct tcttttgccc ggctcccgtc gtttgactgc 2418541 ctgcaccgca agctgacaga actgttataa gcgaaaataa tattgccatg aatgctgttt 2418601 tcgttttcat ctcatcgccc catttatttt tcaaaacttg attttgaata atctgccccg 2418661 agccattttc ggcttagttt ttttagcgtt ccgtttttct ccagcttttt aatcgcttga 2418721 tccgtgtcat ccgccaaggt ttggctgcct ttattaaaca taaagtacac ctcggtatct 2418781 aataacacgt caccgactgt cttttggcgg aaggcgtgcg ttttattctg aaaatcgacg 2418841 gcaaacggtg tagctatcgt tgcatctgcg cgcccggttt caatttgatt ggcggtatca 2418901 ttgcttccct gtcccgcata tttcaaatga attgggctgc cgtgcgtttt gttgtacttt 2418961 gtaatataat ctgccgcatt tgacgtggcg ccaactatga ctgtttttcc gtgtaagtct 2419021 tttaatgtat gaatcttgtg attatcctct ttcaccgtga tgtacatcgg cgagtagtta 2419081 tatgggactt tatgatacaa aaaacgcttt tctcgttctt tatttttggc catattgtgc 2419141 gcaatcacat caattttttt atttccgaga ctcgtcagca aatttgagaa atccatcgtt 2419201 ttaaattcaa atgtatattg aggcaactcc ttatcgatgg ctttcatcac ttcaatgtca 2419261 tacccggtca attcaccttt ttcatttaaa aacgcaatat tcggaaaatc tgttccagtg 2419321 ccgactatga ccgtttgagc ctgacgatct gttttgttat ttgtttgcga acatcccccg 2419381 ccaagtaatg caaacactga cagcagcaaa accaatcctt tacgcttatt cataggctgc 2419441 ctcacatcat gcccagctgg gcgcacctaa aagcgttggg ttaaatcgtt ccggaatcag 2419501 aaccttgtgc atcatcacac ctatgtcccc gtctttttcc tgctcaaaat acacttcata 2419561 ccctctcctt ctgtacatgt cagcaagcca aggatgcttg cgcgccgatg tgccgagtgt 2419621 cagcgcagga gccttcagca tatctcgaag cactttttct tcaacatacg taagcagctt 2419681 acttccggcg ccttgccctt tatattccgg cagtgtcgca aaccaccaca caaatggata 2419741 ttttgaagga ggcgtctcac tctcccacgg gaacctgatt gtaatcgttg aaatcagctt 2419801 cccatcccgc tccagcacaa tcgctgaatg atgttcaata ttttctgata ccatttggat 2419861 atcagctctc gtggatggcc aatcaatatc cagctgccga atgggctgaa atgcgctgtt 2419921 aaccagtttc aacagctccg atgcatcttc aacagttgcc agtcgaaaaa tatcatcact 2419981 catttttgtc actcctcttc acaaaatata taattcctat ttgtttacta agcttttatt 2420041 gtttatacta taaagcatac tctgatcttt gactaatcaa aaaaagtaaa ccttcacttc 2420101 agtaatttta atgatgaaaa acaggaggga gcacattgga gttacgctca atcaaaacgt 2420161 ttcatacgat tgtaaaattt ggaagcttct ataaagctgc agaaatactc aactactcgc 2420221 agccgacgat atcgatgcgt atgaagcaat tggagcagga tttaggcgta ctgctgtttg 2420281 aaagaggaaa aagcctgcag ttgacaaaag cagggaagct tttttatgaa cgaacaggag 2420341 atcttttgat gcaatacgag gcgcttaaac acaacctctc cgacttaaag gaagaagagg 2420401 caggcattat caacataggg gtttcagagc caaccgccag tctgatattc cccgagattt 2420461 taaaggattt cttaatggat tacccaaaga taacggttaa tatcaaggtt gatgacgcca 2420521 atacctgcag tcaaaagctc ttagacggga cgattgattt tgcagtctgc ggcgagccgg 2420581 agctgattct tgaaaattac taccatccat ttttttatga cacattaaat gtgattgtat 2420641 ctgatcaaca tccgctcgct gagaagaagg ctgtccattt gtctgattta gcagaagagc 2420701 gcttcatatt tacgcccgcc aattgcccca ttcgcttaca aattgaacag catttacata 2420761 gagaactcgg gaatcgctac aaaaaaatgg agctcacaag cagcatgtca catgaatatt 2420821 acgtacgtga aaacatcgga atttcaatct ttaccagcac cgcacattct aaaccgttca 2420881 acggcactaa agtcattcca attctgaacc tggatatcac cccgcccata gggctgttga 2420941 caaatcaaaa agaagttcat tttgaccgcg ccacgaagga cttgatcgcc cggataacca 2421001 aacgttttca gcagcgcagc aaagaattgg aaggaacctc tgataagacc attacaggat 2421061 aactgaaaaa ataaaaacca cctcctgatt catcaggaga tggtttcacg gtttaaagct 2421121 cgatcgtctc accgaccgac atgactttgc cgactccgcc cggcaggctg tcagcgaatg 2421181 cttctgggtc ttgttcgatg accgggaatg tattgtaatg caccggcacg acctgttttg 2421241 cgcgcagcca ttcagcagca agcttggcgt cttcaggccc cattgtaaag ttatcgccaa 2421301 tcggaaggaa agcaaggtcg atatgattca attcgccaat gagtttcata tcagagaaaa 2421361 gtgccgtatc gcccgcgtgg aaaatcgttt tatcttctac agtcagcaaa ataccggcag 2421421 gcatgcctgt gtaagtgatc gttttgtttt cttcatctgt gatggctgat ccatgaaagg 2421481 cctgtgtgag cttcactttt ccaaaatcga actggcggga gccgccaata tgcattggat 2421541 gaacattcaa gcctttccag cctaagtaca cagcgagctc gttcggggct ataaccagcg 2421601 cgttattttg cttggcgatt tgttcagtat caccgacatg gtcattgtgg ccgtgcgtta 2421661 gtaagatgac atccgctttt acatcctccg gctttatatc cgttaatgaa ttccctgtta 2421721 aaaacggatc aaaaataata tgatggtcct tcgtttccac tgtgattaca gaatgtccgt 2421781 gatatgtcac tttcatttct ttcacctcgt cacatgattt tgtttttttt attttccctt 2421841 tttaaaaagc tgaaaaactt atgttgtttg attcttgtta atgacattga ggcctccggt 2421901 ggcttcaatg acagtccctg tcacaaggtc tgagttctcc tcacacaaga aagcgataat 2421961 cctggcaata tcctcgcctg taccggatct tcctatcggc gttttttctt tgccgattcg 2422021 cattctggct tcctctatcg atgcttcttt catgtcgccg acaatgtctc ctgggcaaac 2422081 catgttggcg gttatgccga attcggcttc ttcaatggca attgtcttcg tcaaagaagc 2422141 caagcccact ttcgcagcgc caaatgccga tcggtgaagc cagccgggcg cgtgagccgc 2422201 accttggaat ccgtacgtaa taatgcgtcc aaattgctgt tttctcataa taggaataac 2422261 cgctttgaat aaatgaaaga cggcgcttaa atttccttcc agcatgccat accattcatc 2422321 atcagtataa tcggctaact ttttacgttc aaatatgtat ggtccagcgt tgttaatcaa 2422381 aaagtcgatc cttccgaagc ggtttaaggc agcctctgca atacgcagca gatcttcttt 2422441 tttggtgaca tcacctttta caaattgcag ccggtcaaga caatcgggac aggcttcctt 2422501 caggcggctg actgcctcct catcctgtct gtaattgact gttactgaat acccctttgc 2422561 aagcaacgtt tcagtcactt tgcggcctaa acccttcgaa ccggcagtaa ttaaagcatg 2422621 tcgcacatga atacctccca aagcaacgtc gccgctttca ataaagtgtt tcttcttcta 2422681 ctttactata aaaggcttgc aatatcactt tttacacttt ggcatacaaa aaaagctgcc 2422741 tgtacagaca gcttattctg caggagatga agactcctga tcaggcatat cgacataacc 2422801 gctttgatat gcttctgaaa tgagccttgt tgtctcctgg ctttcttgtt catcataaat 2422861 atagcgttcc ggttcttttt tcatcattct gcctcccatc attatagagg taggttggct 2422921 ataatgacgg gattttatga aggaaatttt aacaaactcc tgctgccacg caagctttcg 2422981 ctttttcaag cgcctgttcc acctgtttga atccggtgcc cccggcgctc attctttttt 2423041 caactgcgta gtaagggtct aacacagtgt aaatatcttc ttcaaatagt gtgctcgcct 2423101 gctgaaactc gccaaacggc atatcgctta aatagatccc tctttcgatg catgtgtaca 2423161 caagtttccc gaccacttca tgcgcttctc tgaacggcat tcctttttta gctaaataat 2423221 cggccagttc cgtcgcgttt gaaaagtctt gttttgttgc ttgcttcatg acgtctttgt 2423281 ttacagtcat tgtttggatc atgcctgtga agatttgcag gctgccctcc accgttttca 2423341 ccgtgtcaaa catgccctct ttgtcttcct gcagatcttt gttgtaagcg agcggaagtc 2423401 ctttcatgat cgtaaacagc cccatcatat cgccgtatac gcgtcctgtt ttgccgcgga 2423461 tcagctccgc catatcaggg tttttctttt gcggcatcat gctgcttcct gttgcgtacg 2423521 tatcgtcaag ctcgatgaat ttaaactcct gcgagcacca taaaatgatt tcttcagaga 2423581 aacgggatag gtgcatcatc agcatactgc tgttgcttaa aaactccaaa atgaagtctc 2423641 tgtcgctgac gccgtccaag ctgttttcat aaatggcatc aaagccgagc agttccgctg 2423701 aataatcacg gtcaattggg aaggttgttc ccgcgagcgc cccgcagccg agcggagatt 2423761 tgttaatccg cttcattgaa tcctgaaaac gctccttgtc gcgctcaagc atccagaaat 2423821 acgcaagcag atggtgagcg aatgaaatcg gctgggcgcg ctgcaaatgt gtgtagcccg 2423881 gcagaatcgt ttcaacgttc gcttccgcct tttcaatcag cgcactttgg aatgcctcaa 2423941 tcagctcgat gatgtggccg acatgattct tcaagtataa atgcatgtca gtcgccacct 2424001 ggtcattccg gcttctgccg gtatgcagct tgccgccaag aggaccgatt tcgtcaatga 2424061 gcattttctc aatgttcaaa tgaatatcct cataatcgac tgagaattcc aatgctccct 2424121 cctctgcttt ttgcaaaagg gtattcaggc cctctcggat tttcaactct tcttctgctg 2424181 tcagaatacc gcattttttc agcatggcag catgtgcgag agaccctgta atgtcttcag 2424241 caactaaatt ttggtcaaat gatatggacg cgccgaactc gtcgacccat ttttccggtg 2424301 ttttttgaaa tcggcctccc caaagcttct tcatgcttta atctgctcct tctttttcac 2424361 gatgctgttc acttttgtcg gaagtcccca aagctcgata aatccgattg ctgcatggtg 2424421 atcaaatgca tcgtcttttg tatatgttgc aagtttttca tcatatagag agtattccga 2424481 tttacgtcct tctacaattg catggccttt aaacagcttc acgcggacaa tgcctgtgac 2424541 atgcttttgc gtttctttta agaaagcgtg cagcgcgtct tttaacggtg agaaccataa 2424601 gccgttgtaa atgatttctg acattttttg ctcgatgatc ggtttaaagt gggctacctc 2424661 tttcaccagt gtcaaatctt ctaattcttt atgcgctttg atcagtgtca tcgcaccagg 2424721 gcattcgtat acttcccggg atttaatgcc gacgaggcgg ttttccacgt ggtcgatacg 2424781 tccgacaccg tgcgcgcccg ccatttcatt cagcttcaag atcagctcag aaagcgagta 2424841 ggaaacaccg tcaatggaga caggcacgcc ctgttcaaat gcaatttcaa tcacttccgg 2424901 cgtgtccggc gttttttcca gcggagctgt taaatcgtat gcaccttctg gcggcgccgc 2424961 ccatggatct tctaaaatgc cgcactcatt ggcgcgtccc cagaggtttt ggtcgataga 2425021 atacgggctg tcaagattga tcggaatcgg aatgccgcgg ctagccgcat attcaatttc 2425081 ttcttcacgt gaccactgcc attcgcgaac cggcgcgatg acttctaggt cagggtttaa 2425141 tgatttaatg gagacttcga aacgaacctg gtcatttcct ttccctgtgc atccgtgggc 2425201 aatcgcctgt gcatcttctt tttccgcaat ttcaaccagt tttttcgcga tcagcggtcg 2425261 agataatgcc gaaacaagcg ggtattttcc ttcatacatt gtgtgggcct gcaaagagat 2425321 aagcgcgtaa tcctgtgcaa attcttcttt tgcatcgatc acgtaggagt ttgtcgcgcc 2425381 gacttcaagc gctttctgct gaacaaatgc caaatctttg ccctcaccga catccaggca 2425441 gcaggcgatt acattatatc cttgctcctg aagccatttt attgcgacgg aagtatcaag 2425501 acctcctgag tatgctaata cgactttttt ctgttctgac atgataaaaa tcccctctca 2425561 accgtgtttc tattttgtat aaaaataaat tatatttaat aaaaatacat tttgtatgta 2425621 tacactttaa caagtacgtt tcgttttttc aagcctttta taaaaaaaac ttcacctaaa 2425681 tttcaggtga agtttcatag tatttattca tttacttgtc ttttctgatt tctctgacca 2425741 catgcgcaag ttcgggaata atcagcttat tcattgccag ctttactgcg ccgcttgagc 2425801 ctggcgttga gaaaacagcg gtatgctgaa tgacgccggc agttgctctc gacatgattg 2425861 cggcagagcc gatatcctct gtataactca gcatcctgaa tatttctcca aagccgggca 2425921 gttctttcga aaacagcggc gttatggctt caattgtgac atcccgatct gctatgcctg 2425981 tccctccgtt taagagtacc gcgtctgtct gttcatccat gcagcccgca agcactgacc 2426041 gttgcaaagc atccttttcg tcttttacaa tttcatatgc ggcaatatga tgaccggctt 2426101 cttctaaaaa tgagatcatc agcttgccgc ttttatcggt ttcatctgtc ctcgtgtcac 2426161 tgacagtaat cactttgcac cgaacgatat cgggagcttc ttgtttatgc tcttgaacgc 2426221 tcattggccc acctctttta tgttttctgt ctgtcactat catgcatcaa caaaaaagca 2426281 cattcaagag aatgtgcttt catgcgattt attttgctaa acgaacaacg tcgcgcgcaa 2426341 tcatgacttc ttcatcagtc gggatgatca tgacttttac tggagaatgc ggatagctga 2426401 tgaaagcttc ctcgccgcgc acgttattaa gcgcagggtc ccagtatacg cccatgaatt 2426461 ctaaaccgcg aagaacgcgt tctctgactt ccacactgtt ttcaccgata ccggcagtaa 2426521 agatgatcgc atctacaccg ctcattcttg cagcgtaaga accgatgtat ttgtggattc 2426581 tgcttgcgaa tacttcaaga gccgtttccg cgcgctcatt tccttctttc gtagcttcaa 2426641 cgatgtcacg aagatcgctt gagaaaccgg aaatgccgag cagtccgctt tttttgttta 2426701 atgtattcag tacttcgtca gccgtttggc ctgttttctc catgatgtat gggatcaggg 2426761 cagggtcgat gtttccagag cgtgtgccca ttgctacacc ggcaagcggc gtaaagccca 2426821 tggatgtgtc aatagatttt ccgccttcaa cagcggcaat acttgctccg tttccaaggt 2426881 ggcaggaaat caggcgcaag tcttttaacg gacggccgag aagctctgcc gcacgctcag 2426941 ttacatattt atgtgaagtg ccgtggaagc cgtatttacg gatgccgaat ttttcatagt 2427001 attcatacgg caagctgtaa aggtaagact gctcaggcat tgtttggtgg aatgctgtat 2427061 caaatacagc taccgcagga acatttggaa gcacttcttt gaacgcttta attccaacga 2427121 tatttgccgg attgtgaagc ggtgccaatt cagaaatatc ttcgatttcc ttaatggttt 2427181 catccgttaa taaaacagaa tcgctgaatt tttctccgcc gtgaacgaca cgatggccaa 2427241 ttccgtcaat ttcattcaag tctttaataa tgccgaattc cgttaactta ttcagcagca 2427301 ttttaacagc taccgcatga tctggaatat cagttacttc tgtatttttt tcgccgttca 2427361 cagaaattgt gaatacgctg tcggcgatac cgattcgttc aactaaaccc ttcgttaaaa 2427421 cggtttctga aggcatttcg aaaagctgaa atttcaaaga cgagcttcct gcgttaattg 2427481 caataatttt ggacatgatt gacgctcctt tatactctgt atcaacaact tcgtttttcg 2427541 tacttttttc ccggtgaata tcaacatctt ctccgaaaaa tatctgactt ttccatttaa 2427601 acattgtcat gtcggctttt caagtcaact tgcgtattga taacgcttac aataagaagt 2427661 cgttattttc agacacattc actataggtt ttgtattgat gaacgcttac aatttgcggt 2427721 ttttccctct gtattttgtg tttcaaagct ggattcaatt cgtcaagtcc ggtcttcaaa 2427781 agcataaata aaagcagctt aggcatcgac ctcatacggc tgtctaagct gcttttaaaa 2427841 cacttacttt tcttttttaa accattcatc aaattgagcc atcatatcaa gcatcgcctt 2427901 ttgattggag aaagacggaa gattcgcaag cagaatttgc cccggcgctt tcgtattctc 2427961 tccttgtttc tgaagcacaa ggatgctttt ggcatgagct tcgtctttaa aaatagattt 2428021 tggcagctgc aacagtgcgt tgatatgaac cttatctttg aaaaactgtt tcagcttgcc 2428081 gctttgggag ctctcaaaca aatgattcgg aatcataaaa aataagtagc cgcccggttt 2428141 ggtatgcttg acgctctgtt caataaacag atgatgagcg aaggaatggc cttcgtcagc 2428201 tttgagctca aacgcttctg ctccttcgtc attcggataa tagccgactg gcagatcaca 2428261 aatgaccgtg tcaactggat cgataaacaa cggctcaagg ctgtcctggt ggaaaagctc 2428321 aagctctttt ttcagaaggt tcgcttgggc ataggcgatc ttcaagagca catcatcaat 2428381 ttcaatgcca aagctgtttg ccgttttttc agacagctgg ttcagcacgg taaacagaag 2428441 gttcccagtt cccagggctg gatcaagaat ggtcagttcc tttttgtccg ccataaattt 2428501 attcaccaaa tagctgatga aaagcccgat cgtatccggc gtcatttgtc tgtttggatg 2428561 cgagatatct ttcattcctt taaggacggc aagctgaaaa gccttgcgta cccactcatg 2428621 ctcatacgtg ccgaattccg ctttttcaag cagagcctga agttgtttgg ttttctgatc 2428681 agcaggcagt ttcagctgat ccgttttttc aagaaaatac atttctcctg cttcggccag 2428741 cgcctctata tatgaaatct gcaattcatt ctttatcata atcgcggctt cgtttaacag 2428801 ctcatacacc gcacctacat ggtctttttg catattgtgt tcctccttgc catgaaaaaa 2428861 gctccggcgg cagcctggag cttttttccc tgcttacttt actaatgcct tagcagcctc 2428921 aattggcttt tcatagttcg ggtggtttgt tgcttcgctt acatattcag cgtaaacgac 2428981 ttttccgttc tcatcaagga caaatacgga acgcgcaagc agacgaagtt ctttaatata 2429041 cacaccgaac gcttcgccaa atgacatatc tctgtggtca gacagtgttt ccactttgtc 2429101 aattccgtta gcgccgcacc agcgcgcttg cgcgaatgga aggtctgcac tgattgtgta 2429161 gacgttgaca tctccaagct ttgcagcttc ttcgttaaaa cggcgtgttt gtgcatcaca 2429221 aacacctgta tcaattgaag ggataacaga aataatcgtt acctttcctt tcatgtcagc 2429281 taacgatttt tcttcaaggc tgttagtcag cactgtgaaa tcaggagctt gatctcctac 2429341 cttcacttct tgtccgacaa gtgtaaccgg accgcctttg aatgtaattt cagccattat 2429401 aattcctccc ttttgtatgt atgtctctat catagtaaag tttcctgcaa actgcaaagt 2429461 ttatgccaaa aaaaagttaa ctgcggccag cgcagttaac ctttttttaa taattcatat 2429521 tgttcatttg gttttgattt tggccttggc tttggttttt gttatttttc ttgaacattt 2429581 gctggatgcg ctcgagtgtt tgaggggctg cgtctaaaat tttctctatt aaatgggtat 2429641 tttcatctaa atgaagcatt ctgatgcctg tcgatccgac aattaaaaac gcgatcggcg 2429701 taatggacac accgcccccg cttccgcctc cgaaaggaag tttctgttct cttgtctcat 2429761 cgtcttccga tttcttttcg gccggctttc cgccaaactc gcttccgcct gcggcgaatc 2429821 cgaatccaac tttagaaaca gttaaaatca cacttccatc aggcgtttcc actggatctc 2429881 cgatgatggt gttaacatca atcatttcct tcaagttttc cattgcggtt ttcattaaac 2429941 cttggatggg atggtctgcc atatacgctt cctccttaaa ctgatgaatc attctttgaa 2430001 gtcattctag ccgacggatt cttctttaat acggatagct cccgtccgta tttgacgaat 2430061 ttgaaagctg caagcatagc atgtccaaag cgaaaaaaga atatacactg aaaatgggtc 2430121 ttggaaacag ggacttgaaa cgacgggatc acctcataga caggtttatt cacaaagtcc 2430181 aggtggtcgt agagcattgc tgcgataccg cccttcacgc cccatacagc accggttaac 2430241 acacctgtca ctgccgcgtc ctgaattccg attactgtaa cccattctag ttttgtgata 2430301 tgtaaatgcg cgagaaaaga cgcgctgatt ttccgcagtc tggtgacctg atgcaaaagc 2430361 atttcgattt tattaatgct ttgctgcaca tcgttttgtg taattttttt ctttccgctg 2430421 ctttttttca ttttggattc agttttttgt ttgatatcca ctgttccgtc ttctttgttc 2430481 accttaatcg ccgggattgt ttttttgatc cttataaggc caaacagcgc cgtaatcttc 2430541 aaggtcaatt tgtcattatc atcggcatga agatactcca gcgcgacatg gattttcatt 2430601 ctgagaagca gtacgatccc tatgagaata agaatggctg tcagtacata caccatattc 2430661 ttcacttcct ctaggagcat tatcgccaat tcctaaaaaa ataaacccgg acggaagtcc 2430721 gggttatcgg ttatttgcgg tataattttt catgcaccac ggtggtatcc gcgatgtaat 2430781 catgaatccc ttgttttgta ggtgaaaagg caacaacgat atataaaatc caaatcttat 2430841 caatataccg tccaaccact tcacgaaaaa tcactgtact ccatgtcagc ttgctatctt 2430901 gcttcacaga aaccactttg aggccgaaca ccattttacc aagcgtctgc ctgaagtatt 2430961 ttgtcatgag tgcgaaatag gcaagataca caataagcgt tgtcacactg taggccgaga 2431021 aggtaaacat gccggatgtt ttcggcagat ccaatacggt aaagagggga gaaacgagca 2431081 aatggtttaa tccccatatc acgagccaat caagcaggaa agcccagaaa cgaacccaaa 2431141 agccagcata ggcatgtgtc agcagctccg cttcttgcgg gcctttgatg tcattgcgct 2431201 ctaactcttc atatgtcgcg tccattattg ttccctccta cttcgcatag agatacatca 2431261 ttctcggcga accggattgc gatagaattt ctctcatatt caaaaaatca atttcacttt 2431321 taaacatttt gttcgcgccc atggaaaaca gtgagcctaa tccgaagctt tcctcataag 2431381 aaatgacaga ggcgtttttc aaatccttgt gatccttttt catggccgta atggtatcgt 2431441 cataaaaacc aagctcatca acgaggttca gttttttcgc ctgccgtccg tcatacacgc 2431501 ggccgtccgc aattttcttt acctctgctt tcggcatgcc gcgccctttt gaaatgacat 2431561 caacaaagcc ttcatacgaa ttatcaacca tcgattgcat gatgtttttt tcttctttcg 2431621 tcatctcacg ggaaggagac ataatgtcct tatgggcccc gctcttaatc gtttcaaaag 2431681 aaatgccaag cttgtcggca agctttgaat aattgacgct ttccataatg acgccgagtg 2431741 acccggtcag ggtttccggt gtcgcaaaaa tcttatcagc cgctgttgag atgtaatagc 2431801 ctcctgatgc tgccatcgaa cccattgaca cgtaaatcgg ttttttcgtt tctttcttga 2431861 tttcttccag tttcttatgt atttcagcac tttcatacac tccgccaccc ggagaattca 2431921 ccttcagaac gatacctttg accgtcttgt catcttttgc gcgctcaagg ttttttaaga 2431981 acgttctgtg gttatatccg tctgcaccaa gcagactgct tgagtcccca ttatcctgaa 2432041 tggtgccgct gacctctaat acggcaattt tacttgaggg actgccgttt tccagcgtct 2432101 tctcctgcga ttcatccgtc agtgatgtga gatccgtttg agcgcctttg acgctttcaa 2432161 agaaactcat agagatgctg acgataatag acacgccgaa aatccccaga gcaatcacta 2432221 atgcaatcca tctttttgca ttcatttttt ctcctccttt ttcctaaact ctctcattat 2432281 acgattcaat atgaaaaatg tttcacttca tgagaaagct ccggcttaac gggctgccgg 2432341 caaacgtggt acacttatgg ccaaaggtat tttatcacaa atactggatg gcagaaaaac 2432401 ttaaatatga cagcaaaggg gaaatgggat atgaccgatc aacgccgtaa tgtttatttt 2432461 tttcacaaac aggatcagga aacgaacgaa caagcccgct cgttaacaca attagcggaa 2432521 gagcatggat ttaccgttgt gaaccagcac tcagacgcca atattatcgc tagcattggc 2432581 ggggacggca catttttgca ggcagtcaga aagacgaatt ttcgtgacga ctgcttgtac 2432641 gtcggcatta ccaaaaaggg gaaagctcat ttatattgcg actttcatag tgatgagcga 2432701 gaaaaaatgg tcgatgcaat gacgtttgaa caaattgaag tgagaaaata cccgctgatt 2432761 gaagtgacag tggatcaagc cagtcctttt cactgcttaa acgaggtatc catccgctca 2432821 agcatcatca aaacctttgt gatggacgtg ctgattgacg atctgcactt tgaaacgttt 2432881 agaggtgacg gaatgattat ctcaacgcct acagggagca ccgcctataa caagtctgtt 2432941 gcaggagctg ttgttgatcc attgcttcca tgcatgcagg tatcagagct tgcatccctt 2433001 aacaataata cctaccggac actcggctcg ccatttgtcc tcagctctga ccgaaagctg 2433061 acccttcgtg tggtgcagga cggcaacgaa cacccaatca tcggcttgga caatgaagca 2433121 ctcagcacga gaaatgtgaa aacgatcgaa atcaaactgt ctaataagaa aatcaaaaca 2433181 gtcaaactaa aggacaattc attttgggaa aaagtgaagc gtactttttt atagaaaata 2433241 aaaggacagg ctgctgcctg tccttttatg atttctcata tacaatctgg ccgttaatca 2433301 cggttttttt aatctctaaa agatgaagct gtgcggggtc aatggcaaac ggatcaccac 2433361 tgagaactgt aaaatccgcg tcatagcctt ccgcaatttt tccgcgtgac ttctctttat 2433421 aaatgatacc ggcgctacct tctgtataaa gctttatcgc ttcatataca ggtaaacatt 2433481 cactttcatt atagcttggc ccgttttgct catgactgct tttccggagg accgcggact 2433541 ggatccctag aagcgggtca acaggctcaa tcggggcgtc tgaaccgccc gcgcataaaa 2433601 tgcctttaga tatgagggtt ttccaggcaa atgcagtctt catccggtct tttccgagac 2433661 ggtcaatgac ccacggaaag tcgcttgcaa cgaagtgcgg ctgaaggtca agtgcgatcg 2433721 gcatgcgtgc tgctctctcg attaattcgt tatcaagcac ttgagcatga ataagccgat 2433781 catgccggcc gtttttgggc ggatgctttt ctattgcgtt cagcactttt tcaaaagcaa 2433841 gatcgccgat tgcatgaaca gcaacctcca tccctttttc tctcgctttg cgaatgagcc 2433901 ggccaagggt ttcgtcatcg tgaacctgaa caccatttgt tgatggatca tcctgatatg 2433961 gttctttcaa taaagccgtt ctcccgccaa gcgccccgtc cgcaaagatt ttcatagcac 2434021 cgaactccac atacgggccg gacagcttct ccagctgctc ccatcgatcg acagcttcat 2434081 gatgaacgag caaatggcag cgaaacggat actttccgcc agcggcagct ttctcataag 2434141 ctttcatcgg caccgaaaca tcaccataat aggacaagtc ttccgaatga ccgcccgtca 2434201 ggccttttgt ccagcaatcc tttattgcag ccgttaatgc ctcatcaaca tagtgctggg 2434261 agactggcgg gacagccttc agaatcaaat cctgcgcctt atcaaacagg agtccggtcg 2434321 gctcgccatt tgcatctttt acgatgactc cgccgtcagg atcaggagta tttcttgaaa 2434381 ttcccgctgc ttgaagagcc gcagaattga cagctattgc atgccggcat atacgcttga 2434441 gcaagacggg cctgtcagga aacaggcgat caagatcatg cttagtcaag tagtcaggtg 2434501 tctcaaactg attttcattc cagccttctc caatgagcca atcgttttta ggaagctgcc 2434561 gctctctttc cttcgcagcc tgtaaaattg aatctttcga cgtcagtgcg gacagatcga 2434621 gctgaagctg tttctcaccg tggccgatca aatgtagatg gctgtcaaca aaaccgggga 2434681 acatcactgc tccgttcagg ctgatttctt ctgtttccgg cgacccgtac ttttccttca 2434741 aacgttcata gctgccggtg ccttttataa caccatcctc aacataaact gcctcagtcc 2434801 gatcgccttc ttcgagcatc gtataaatga aaccgccgtg ccatatcgcc ttcattcacg 2434861 ttcactctct ttctttacgc ctttttattg gctttgagct gttcttcacg ttttcttaat 2434921 tccactcgtc tgatttttgc agaagccgtt ttcggcaggc tttccacaaa ttcaatttct 2434981 ctaggatatt tgtatggagc ggtaatcgtc ttcacatggt tttgcagcat tttgacaagc 2435041 tcatcactgc gtttttcatg attttgcagg acaacatatg cctttacgat ggagcctctg 2435101 atttcatcag ggcttgcgac aacagcacat tcttttactt ctgggtgctt aacaagcgcg 2435161 tcttccacct cgaaaggccc gatcgtatag ccggagctga taataatatc gtcatttcgg 2435221 ctttcaaacc agaagtaacc ttcctcatct tttcttgctc tgtctcccgt taggaaataa 2435281 tcgccgcgaa tttgtgtttt cattctttcc ggatctttaa aatactcttt aaagagcgca 2435341 ggcgtactga ggtgaacagc gatatcgcca acctcaccag gtttgcagat ttcaccgtct 2435401 tcatttatga tctccacctg atttcccggt gtcggttttc ccatgcttcc cggtttaata 2435461 ggcgtatctt tcaaaacacc aaccaaaagc gtgctttctg tttggccata tccgtcccgt 2435521 accttaatgc caaagtgctt ttggaaaaca tcaatgactt cacggttgag cggctcacct 2435581 gcggaaacag cgctgtgcag ggcagaaaga tcaaagcgtt tcaagccttc aaccttcgcc 2435641 attaagcggt attctgtcgg agtgcagcag aaaacattga ttttgtagcg atttaaaagc 2435701 tctagatatt tttctgcttt gaatctgccg tggtacacaa aaccggttgc tccgctgcca 2435761 agcaccgcta aaaacggact ccatacccac ttttgccagc caggggcagc agttgcccag 2435821 acgatatcct tttcagaaat gtcaagccaa gcgccggcag aagtttttaa atgagcaaat 2435881 gcccatccat gtgtatgtac aacacctttc ggctgacctg ttgtcccgga tgtataagat 2435941 aagaaagcca tatcatctct tgttgtgtca gctgttttaa attggcttcc gtccgcttca 2436001 attgataaga ggtttttcca gccggcatca ttttcaccaa tagacagtgt aatcagtttg 2436061 tcagccgtac tgacatcccg gaaagcgcca ataaattcgg agtagacgat agcgcctttt 2436121 acctctgcat gttcaatccg gtattcaaga tctttcgcgc gaagcatttc ggagcacgga 2436181 atgacaacca ttcctgattt caggatagcc aaataaacag cataggcttc aagcacccgc 2436241 ggaaccatta caatcagctt gtctcccttt ttaaatccaa gatcagctaa ggccgctccg 2436301 attttatttg tttcttccat cagcttttca tacgaccaag attcttgctt gcccgactcg 2436361 tcctcccaaa gaagagcggt tttttgtcca gcagcactga acttttccat ttcattcact 2436421 aaattatatt gcacaggggc aattaaatct tcacgtttta acacgaacaa ctcctcactt 2436481 tctccaccca ttatacataa atacaggctc tttccgtaag gatatgccta aaagcaacct 2436541 ctgtaaacat agattttata ggccgctggt ccttttttat atgtaaaaaa tgaaaaagag 2436601 tggggatacc cccactccta agccattatg tgaaattgta aattagaatt gtcctccgcc 2436661 catgttttgt tgagcaaaag atacaagacg ttttgtgatc tctcctccaa cagaaccgtt 2436721 agcgcgagaa gttgtgtctg ctccaaggtt tacaccgaat tcagaagcga tttctaattt 2436781 catttggtcg atcgcttgag cagctcctgg tactaaaagg ttgttgctgt tacctgagtt 2436841 attgttagcc atgtgtctca cctccttgtg agtatagaat gtgtcaaaac acatggcttc 2436901 attcagaaaa actttggtaa ttgtatacag gagctgaaaa ttgatttaaa agagttcagc 2436961 gaatttatcg ttagcttctt gttcgctata aagggtcatt gtctcaatgt tatctaccgc 2437021 ttcttgaata tacggctcga aatcaacaaa gctttcaaag tgttcaattt tctctttttt 2437081 agggcgtgtt ttcgggcttg gcggtgtaaa gatcgtgcag cagtcttcaa acggctgaat 2437141 acttgtctca tatgtgccaa tttcccgtga tttttcgatg atttctgttt tgtccatggc 2437201 gattagcgga cgcaaaatcg gtgttgacgt caccgcatta attgcataca tgctttcaag 2437261 cgtttggctc gctacctgac cgaggctttc tcccgtaata atggcaagcc cgtttctctt 2437321 ttctctgatt ctgtcggcta tctgaagcat gaggcggcgg gttgccgtca ttgtgtaatt 2437381 ttcaggaatt tgtttttgga tgagctcttg cgtttttgta aatggaacaa tatgaagtgt 2437441 catgcttccc ccaaaacggg acagacattt cgccagatcc attacctttt gctttgcgcg 2437501 ctcgcttgtg tatggcgggc tgaagaaatg aacagcttct accgacaatc cccgtttcat 2437561 cgcataaaaa ccggccacag ggctgtcaaa accgccagaa agcatcagca tcgcttttcc 2437621 tgctgaacca actggcagcc cgcctgcacc tttttcatca cgaattgtca aaaatgttgc 2437681 ttcttccctg atttcgattc tgagcgggat gtctgggttg cgaacatcga ccgtcaatcc 2437741 ttctgtattt cgcaaaatat ggccgccgat ttcagcgttc atctggtttg tatctaattc 2437801 aaattgctta tacgctctct ttgtcgcgac tttaaacgta tcacctggtt tatactgatc 2437861 tttgatagcc tttagtgcgg ttgccttaat atcatcaagg cggctgtcac acttaattgc 2437921 caggctgaag ctttgaatcc caaacacttg ctttaaatga ggaaaaagag cctcaggatc 2437981 ctctccattt aatgtaatcg tcatacgatc cctgttggaa aagtatttta aattcggata 2438041 gtctttcaaa acgagtctga tgttttgttt taagcgctca ataaagcttt ttctgttttt 2438101 gcctttggtc gaaatttccc caaaacgaat taatatatga tcgtaattca tgttctacct 2438161 catcatttcc cttaattttt tgatgccagg acgaagcgcg ttcataaacg gttctgccac 2438221 atcgcttgtc tggctgtaat ttaaactgat tctgatgctg cttccggcaa tctgctctcc 2438281 tttgcccatc tctaagagaa ccttgctggg cttatgttct tttgccgagc aagccgatgt 2438341 tgtggagacg aatatatcct gttcctcaag catgtgtaaa agcacttccg ctttaatccc 2438401 cggtacagag aaattaataa tgtgcggcgc gctattcatt tgaggcgtgt tgataacgac 2438461 gccctcaatt tcactcagcc tattcataaa caattccttt acggcagtca tcgtgtcaag 2438521 ccgtgtgtca aaatcagcag aggccagatt aatggccttg gcaagcgaaa ccgcaccagc 2438581 agtatgttct gttccggccc gtatgccttt ttgctgagag cctcccgtta tgagcggaat 2438641 aaggcgtgtt ccttctttta caataagtgc gcctgtcccc tttaggccgt gaaatttatg 2438701 ccccgaaatt gaacatagat caatgccggc cttttcaatt gccaagggca ctttatagat 2438761 gccctgcaca taatcgacgt gaaacaaaat gttcgaatgc tctttcagca cttctcctgc 2438821 cgcttcaatc ggctgcacgg aaccgacttc attgttcaca tgcatcatgc tgacaagcac 2438881 ggtatcggga cggatggctg cttttagatc ttcaatagaa acaaatccgt cttcattcac 2438941 agaaagataa gtgatatcaa acccgaacaa ctctttcagc tgttctaacg attccgtaac 2439001 ggatggatgt tcaatagaag tggcaatgat atgtttgcct gtttttatct ttgacaaagc 2439061 cgctcctttt aaagccgcat tattggcttc tgtggcgcct gacgtaaata caatatcata 2439121 tttttttagg cctaaggacc ttttgatttg atttttggct gcttgaagca gctgttccgt 2439181 ttcggctcca tatcggtgca aagatgaagg attgccaaag tatcggctgc tcgtctgttc 2439241 atatacgttc aagacttcat cgtaaggctt cgtcgttgaa ctattatcta aatatatcat 2439301 cttttttact cctttatgaa agcggtacaa ggtatgatat ttatgttacc ataacaaaat 2439361 ttaatagaaa attacgaaaa actagtattg acttctaatt tttttaccat ataataagat 2439421 ttgttcgttt cgtcatatta tctgacaatt aattgacaga atattttaac ataattatta 2439481 ggaggatttt tttcatgaaa cactcactgc ctgtcaaaga taccattatt attggtttca 2439541 tgctatttgc gttattcttt ggagcaggaa atatgattta tccgccggaa cttggacaag 2439601 cagccggaca caacgtctgg aaggccatcg gcggattttt actgacaggg gtaggcctgc 2439661 cgcttctcgg cattatcgcc atcgcattaa ccggtaagga cgctaaaggc cttgctgaca 2439721 aagcgcaccc tgttttcggc acaatcttta ctgtcgtgct ttatttatca atcggaccat 2439781 tattcgccat cccgagaaca ggaactgttt catatgaaat tggcgctgtt ccgtttttga 2439841 ctggtgtacc agaaagactt tctttattaa tatttacact tatctttttc ggcgttacgt 2439901 actatttagc gttaaaccca tctaaggttg tggatcgagt cggaaaaatt ctgactccca 2439961 tcaaattcac aattatttta atcattgttc tcaaagccat cttcacgccg atgggcggat 2440021 tgggcgccgt gacagaagca tataaaggaa caccggtttt taaaggattt ttagaaggct 2440081 ataaaacaat ggacgcactt gcttcaattg tatttggcgt tgtcgttgta aatgctgtaa 2440141 aaagcaaagg cgttacacag tctaaagctc ttgctgcagc ctgcattaaa gcaggtgtga 2440201 ttgccgcttt aggcctgact ttcatttatg tatcccttgc ttatttaggt gcaacaagca 2440261 caaatgccat tggtcctgtt ggtgaaggag ctaaaatttt atctgcgtct tcccattatt 2440321 tattcggttc attgggcaac atcgtactcg gagcagcgat tacagtcgca tgtttaacaa 2440381 caagcatcgg ccttgtcaca tcttgcggcc aatatttttc aaaacttatt ccggcattat 2440441 catataaaat tgtcgttacg attgtcacgt tattcagctt gatcattgcg aatttcggac 2440501 tcgcgcaaat tatcgcgttt tctgttccta ttttatcagc tatctatccg cttgccattg 2440561 tcattatcgt tctttccttc atcgataaga tctttaaaga aagacgcgaa gtgtacatcg 2440621 catgcttgat cggtacagga cttttcagta ttttagacgg tatcaaagca gccggttttt 2440681 cacttggatc tttagatgtg tttctaaatg cgaatcttcc tctttacagc ctcggcatcg 2440741 gctgggtgct tccaggaatc gtcggagcgg ttatcggcta tgtgctgacc ttattcatcg 2440801 gaccatccaa acagcttaat gaaataagtt aatgtcacag aacgcctgcg ttattgcgca 2440861 ggcgttttgt aataaaaaaa gagcctgctc attacactgc gggctctttt tcatggtcgt 2440921 gattatctaa gcggatatgt cagctttgat tttttcaact gcacctggcg cagccttttc 2440981 tacagcggca gcggcaattt cataagagtc gtcataatca aaagcataaa aacgtctttc 2441041 cgcttctttc agctgttcag ataaaatatg attctggctt ctgaaccggt ttccgaactg 2441101 aatgattttt tcaatgagga tgacctgctc gacaagttcc tctgattccc ggcttgccct 2441161 gttgacgata tcttctgctt gtttcaaatg ggctccggct tcttccatat ttaatggaag 2441221 ttcgtttagt tgattgaccg tttcttgaat atgatgatgc gcgttctcca gcatctcttg 2441281 aatatggctc ggaatgcctg gaatgttgct agtcttcagc agtcttgctg tctcagaaat 2441341 tgtttttttc aaattgctga gcgtctccct cgcctgaagc tcttcttttc tcagcgcttg 2441401 cagattttca cgatactcgg catgctcttt tttcacttct tcaatttgct tctctattga 2441461 agcaacttct tctactaaaa gtgagtaggc gacatgctct gcatcaagct tatctttaac 2441521 ggatgatagc agctttccaa tttcatcaag gcgcttttca aaagcctgct gtttgccgag 2441581 ctcaccggct gtcagcctgt agctttcctt caccagctca gtttccgctt tcgtatgctc 2441641 tttctcttct ttaagcttgt cgtaagcaat aatcaattca ggcattttgc ttagtacgga 2441701 ttgaccggct tcaacttcgc cctccagctg ctgataaaca gattgaatat tttcgtcaat 2441761 gagctgcagg attgcggacg cttcatcaat atccagttca gtcatcagga catgttccgc 2441821 tcgtttcagc tggtttgaca gattttctaa ttccttatca agctggatat gctcaagctt 2441881 gtaccctttt tctttcattt cgccatagcc atccttgagc tttgcaatct gtccgggcac 2441941 cgtctgttta cagtcagcta acagcttcgg cacatcatct atgtatgact gaagccgttc 2442001 aagattgcgg tcctgctcaa gcagtacttt tcgtgcagta atatagtttc cgccttctgt 2442061 ttcttcttca aattgtttga tgccgctcca aatttcgtcc agatcctttt caaggctgtc 2442121 ataaagctcc ccgtaaaggt ggctgtaagc cagcaggttt tttcgagatt tcgaatagcg 2442181 ctccctcacc tgttcaatct cttcacggct cttttcctca cttgtgacaa gatcgctgat 2442241 ttcccgaaga atcttttcaa tgcttgattc agccgctgtc agcaggtcgt cgatatgaac 2442301 gagcacttga ttggcctttt taaaccggta tttgtctgca ttttcctcgg catcataaag 2442361 gagctcttca actttcggca tgtgggctgt gacaatctca tcccattctt cacgccactt 2442421 ctcaaagaac tcttctgtct gacccgtcat ttttaaatgt tttattttag acatttcttc 2442481 cacgatcgac cgattcagaa tttcaatctt ccacgattcc agccggtcga tttcggcgta 2442541 gatttttttc ctgaaaaagt agcctgccgc aaacagcgca agcagtacaa ttaataatcc 2442601 aatgacaaac tccataatga gcccccttgc tgtttacctt aatctgtcag ggtgttttat 2442661 ttattcagaa agatttcagg atatgtattg agaaaaactg tcgttttcat tgttattatg 2442721 ataccatgta acaaacattt tttgaccaga aatcaaaaac tttttgtgca aaatcggcag 2442781 gatttgacta ttttttcatg gggtgacatc aatgcaaaag cgagacggac atattcacac 2442841 accattttgc cctcacggct ccaatgacac actcagacaa tatgcagaag aagccttaaa 2442901 aaaagggttc gaatcgatta cttttaccga acacgcccca ttgccgccat cttttaccga 2442961 tcccacgccg ctgaaagaca gcgcgatggc gcaagcttct ttggaacgct atattcatga 2443021 aatttccgga ttaaaaaaag aatatcgcgg acagcttagc atacggacag ggcttgaagt 2443081 cgattatatc gctgaatttg aagacgaaat tacattattc ctagacacat acgggccata 2443141 tttagatgac agcatcttat ccgttcattt tttgcgcaca gactcttcct atctatgcct 2443201 tgattatgac gagcatacct tcaaagagct gatttcagcc tgcggaagca ttgaagcggt 2443261 atatgaacaa tattaccgga gtatctattc ttccattgta gcatctctcg gcgtttataa 2443321 gccaaaaaga gtcggtcaca tcacactcgt ccaaaaattc atcaagctgt ttccatacag 2443381 catgtcagag catattcgcg gcctcgtttc tctgtgcctg aatgccattg aagaaaacgg 2443441 aatggagctc gacttcaata cttccggctt aagaaaaact tacgctggcg gtatttatat 2443501 cgaggattgg atgctgaatg aagcgaagca aaagaagatc ccgcttgtgt ttgggtctga 2443561 tgcccatcaa gcgggagatg tcggatatgc gtatgaggcg tttttggaac ggtgctagtt 2443621 ggtgagcgcc acgtctcctg tccggaagac gcttctgatc caaatcttga tttcttcaaa 2443681 atacatttta taaaaatacg gctcgtgcgg ctgcatgtag agtacttctg aaatatattg 2443741 aggctggaga tagggcatca tcaagagaga ttttaattgg agaataaaat gaggcagcgg 2443801 cagcgttaaa tattcacgct gtttttctcc ttcctcaatg atcagctgga agatatactt 2443861 ttccttcatt agatatgtcg acataatttc cctgattaat gtggagtcaa ttgtgacttc 2443921 ccggtagaca aaacgagtta attgacgatg attatgctga taggataaaa tatcgaaaac 2443981 caattgaaga agctgttcct gcgtgctttg agtagagata ttgcttgccg ctgtttcaag 2444041 cgttttgctg tagccttcgt aaaactctga aactaagtgt tccatcaagc ctcctttgcc 2444101 tttaaaatag taggagatgt gcgcaacatt tacatcagct gactttgcga tttcacggac 2444161 agacgtgcca gaaaatcctt tttggttaaa aagcatgaca gcagattcaa taattttgtc 2444221 tttggtgctt actttcatac ggctcactcc ttcctcttga tactattcaa gcagaaagcc 2444281 gctgttcctg taagaactta tcgacaaatg ccggcagaaa agccggaact ttgttttata 2444341 ttatagaaaa agtgagggtt ttccatgttc catgtcgaaa aacaatctgg agataaagaa 2444401 aaagactatc agcttctgct aaaacagctc gaagccatga ccgaagacga aacagaccaa 2444461 atagctaact atgcaaatgc ctcagcactg ctgtatcatt cgctgcctga agtcaactgg 2444521 gcgggtttct attttgccaa agaagaggat ggacagcttg tgttaggtcc gttccaaggc 2444581 ctgccggcat gtgttcggat tcctttcggc agaggggttt gcggcacagc gtacgcaaac 2444641 ggaaaagtgg aacgtattga ggatgtaaac gcgtttccgg gacatatcgc ctgcgatgca 2444701 gcgtctcaat cagaaattgt gcttccgatt cgtgtagacg gaaaaattgt cggcgtcttg 2444761 gacatcgaca gcccagtgaa aaaccgtttc gacgaaattg atgaaaaata cttaactcaa 2444821 tttgccgaaa cgctagaaaa agcgttagcg cagtaatata aaagcccaaa actgatatcg 2444881 ttttgggctt tttttatttt attgagtcat gaatcatcaa gcggtttttc ccgctccgtt 2444941 tcgcgctgta gagcgcttca tctgcctcat gcacaagctc tttcagcgac ttttttgttt 2445001 ctgtcgtcca gcaggagata ccgcaggaaa tggttacctc gggtttcgta ttttttctga 2445061 ccgcgtaaac cagtcgctcg gtaatccgtt tccccactgc aaccggcaca tttggcaaat 2445121 aaatcgccag ctcctctcct ccccagcggg caccgacatc atgctttcgg atgttgcttt 2445181 taatcactga agcgacttga attaaaatct cgtccccagt ctgatggccg tacgtatcat 2445241 ttacattttt aaaattatca atatcaacaa gaataaaaac acccttttga tggattttca 2445301 tgctgtattg aattttttca tctaaatacg ctcgtgaata cagttcagtc agctgatctg 2445361 ttttcacgag atgctcaagg cggtcgcgaa gcattgaatt ggttacagcc agtgtcgcgt 2445421 gatgaatcag cgcctgaaac agcttgtaca tttcaaatgt aaaagcgtac agctcctgtt 2445481 tcaataaaac cgcaaagcct aaaagccggt cgttttgaat catcggagca gccatcagcg 2445541 agccgtaccc cgccttccca aaaacagact ggccattccc gatgaaaacc cctttttcac 2445601 cttcatacag cttttctttc agctcattat aaaaatctga cggcttcgct tctttaaaaa 2445661 atgctgtgct gcctgggagc aatgttaggt tttcaaaatg gtctatatga aaaaatccca 2445721 cttcttctgc ctgaaacgat tctgccattc tcacagccag atcattcatt gtatcagtca 2445781 atgtcagccg ctgattcagg cgtcgtgatg tttcattaat caattccaaa tttgcgatgc 2445841 ttgctttgga ttgttcgtag agctgggcat tttcaaacgc ttttcccgcg gcgtttgcta 2445901 acagcgacat ttcatcaagg caggcatcag taagaaagct gtcacccgtt ccttcagcct 2445961 tcaacacccc gtatgtgccc tgctgtcctt tgatcggaat ataggcgaca gattcatttt 2446021 tccgcaaaat gtctccggac aaatacactt tgagcgcaaa ggaatcggat ttttcccctt 2446081 ccatatacag ctcttttgca ggaatcccta aacattggtc ttgatcgtgc gatataaata 2446141 aagaaaactc aaaaagagaa aatgtgcttg tcaagctttc taaaagctgc ttcagcacat 2446201 ctgtctgatc aagcagtgaa tggaacagct ctgtcatttt gtatatcttt ttttggtaga 2446261 tcgttttgtt atagagtctt tcctgtttca tcgactggtt taaaaatgaa gcaaccacgt 2446321 ccggaagccc ttcaggaatc tcttcatcct gcctgcacgc aagatggaaa cgcctgccgg 2446381 agccgtcctc aatcagataa catgaagcgt ttatttttga agcggaaaaa cgcgcttcac 2446441 catctgccag ttttgtcaca aagtctgatg gtgacggtgt aagcgaaaca caaagggttg 2446501 aaaaataggt ttgaatagcc gaagtcagcc atatgaaaga gtcggtgaat gtgacttttt 2446561 cagatttggt taataaaaaa tcgagcatat gataatgaaa ggcggataat tgatctttag 2446621 tttgttctac catgttttta tcacctaaaa gtttaccact aatttttgtt tattatatca 2446681 taaacggtga agcaataatg gaggaatggt tgacttcaaa acaaataaat tatataatga 2446741 cctttgtgtg aaatattgca gcctttttgt tcagcttcta tgttttcatt ttgttcctta 2446801 tcaataaggt gtatcgtgta actctctgct gctggagcga ggatacatga aaacaaaatg 2446861 tgcatggtcg aatagagcag acggttttta ttttccacaa aaataaaacc aaaggaggag 2446921 tcacattatg gctcgctata caggtccatc ttggaaactg tcccgccgtc taggaatctc 2446981 tcttagcggt acaggaaaag aattagaaaa acgcccttac gctccaggtc cacacggccc 2447041 aggacaacgt aaaaaattat cagaatacgg tttgcaattg caagaaaagc aaaagcttcg 2447101 tcacatgtac ggtgtaaacg aacgtcaatt ccgcactttg tttgacaaag ctggcaaact 2447161 agctggtaaa cacggtgaaa acttcatgat tcttttagat tctcgtcttg ataacgttgt 2447221 gtacaagcta ggtttagcac gtactcgccg tcaagctcgc caattggtta accacggtca 2447281 cattcttgta gacggaagcc gcgttgacat cccgtcttac ctagtgaaac ctggtcaaac 2447341 aatcggtgtt cgcgaaaaat caagaaacct ttctatcatc aaagaatctg ttgaagtgaa 2447401 caacttcgtt cctgaatacc ttactttcga cgctgaaaag cttgaaggta ctttcactcg 2447461 tcttcctgag cgttctgaac ttgctccgga aattaacgaa gcgcttatcg ttgagttcta 2447521 ctctcgttaa tcgttttaaa aacccctgcc gctatgcggt cggggttttt ttatcggctt 2447581 tcgcctcttg ctggccaaca ctatcttgcg cctgctgctc ccaatgatcc cgctgcagcc 2447641 gttcttttgc aatcgtacac atgagattca cgctttagcg ctcctttcat ttaaaaggtg 2447701 gtgattggtc gtgtttgccc tatctaatat actcttttcc tttcattcct atgcggtaaa 2447761 caaaaagatc ctttgccttc agtggcaaag gatctttttc ttatttatac gtcacaagga 2447821 agtatttttt cttcccgcgg cgcagaacag taaattggtt ttcgatgcgg tcttcacctg 2447881 atagggtata atttatttcc gtctggcgtt caccgttaat gtaaacagct ccgttttgga 2447941 tgtcttcacg cgcttggcgt ttagaaggag ataatttaga ttgcaccaac acatctacaa 2448001 gtgaaagctc ttgggtgctg tcaacttcca tagaaggaac atctttaaag cctactttta 2448061 cgtcttgagc agaaagctct ttaatattgc cgctgaacag cgcttgggag atgttgatgg 2448121 cttgctccag cgcctcgcgt ccgtgaacaa gtgatgtcac ttcttctgcc aggcgttttt 2448181 gcgcttcacg tttttctggc gccgtttctg ttttttcagc gtatgcttca atttcctctt 2448241 ttgaaaggaa cgtgaagtat ttcaagtatt tgacaacgtc acggtcgtct gtgttgatcc 2448301 agaattgata gaattcatat ggcgatgttt tttctttatc aagccagatc gcgccgcctt 2448361 ccgtttttcc gaacttcgtg ccgtctgctt ttgtgacaag cggaatcgtt aggccaaacg 2448421 cttttgctcc ttcttcttct gattttctga tcagttcaag acccgctgtg atgttgcccc 2448481 actgatcgct tccgccgatt tgcagtttac agtttttgtc tctgtaaaga tttaagaaat 2448541 cataagattg aagaatcatg tagctgaatt ccgtgtacga gatgccggat tcaattcttg 2448601 agctgaccgt atcttttgcc agcatgtaat tgatgccgaa atttttacca acgtcacgaa 2448661 ggaaatcgat cacattcatt ttgccgatcc agtcaaagtt gttcgcgatg acagctgggt 2448721 tttctgctgc ttcaaaatct agaaatctgg acagctggtt tttgattttt tgggaccatt 2448781 cggatacgat gtcagcagtg tttaatgtac gctctgcttt ttttccgctt ggatcaccga 2448841 tgaggcccgt cgcgccgccc acaagcgcaa tcggatgatg ccctgcaagc tgaaaacggc 2448901 gaagtgttaa aataggcagc aggtgtccga tatgcaagct gtctgctgta gggtcaaagc 2448961 ctgagtacaa gcggattttt tcttcattca gctgtttatt taacccttct tcatctgtca 2449021 tttgctgaat caatccgcgg aaggataagt cttcaagtaa gttagtcata agataaagct 2449081 ccttttttaa ttaaaataaa aaacgcccct tcgtttacac gaagggacga ttgattatcg 2449141 cggtaccacc ctactaataa gagaatgcaa acattcgtct tatcactttg cctgataacg 2449201 gatcaggtcc gttctttcac tactgaaagc ctggccggct ttgtttgcaa aagcggttca 2449261 tgagtgtatt cgatatatcc gtctgtgctg attttcaccg gccatcagct ctctggaacg 2449321 taaggatatt ctacttgtct caatctttac cttttcatat gaagctatat catttttaac 2449381 ataaataaaa tcctgtgtca acgccgcctt ttaatcctcc attgttgaca gatctccagc 2449441 cggcagatta agctcccatg ccttcagcac gcgcctcatg atctttccgc ttctggtttt 2449501 cggaagctta tctttaaatt cgatctcacg cggagccgca tgggctgcaa gaccctgctt 2449561 tacaaatagg cggatctctt ctttcagttt atcagacggc tcaaatcctt ccctgagtgc 2449621 aataaaggct ttaatgattt ctccacgcac cgggtcaggc tttccgataa cgcctgcttc 2449681 tgcaatagcc ggatgttcga caagcttgct ttccacttca aatgggccga cgcgctcacc 2449741 ggaggtcatg atgacgtcat caactctgcc ttggaaccaa aagtatccct cttcatccat 2449801 gtaagcagaa tccccagaca cataccagcc gcccggcatg aaatacgatt catacttttc 2449861 agggttattc caaatggtat gcatcatgga aggccagccc tttttgatgg cgagattgcc 2449921 cattcggtac ggcggtagct cgttgccttg attgtcaacg atcgctgcct ccactcctgg 2449981 aatcggctta cccattgaac ccggtttaat atccatgcaa ggatagttgc agatgagctg 2450041 actgcccgtt tcggtcatcc accaggtatc atggattcgt ttgttaaaaa ctttatgtcc 2450101 ccatctgatg acttccggat ttagcggctc accgacactg agcacatgcc ggagtgaagt 2450161 tagatcatat ttcgcagcca tttcatctcc cgctcccatc agcatccgaa aagctgtcgg 2450221 cgcgctgtac cagacattga cgccaagctg ttcaatcgtt ccataccagc tttccgggct 2450281 gaaacgtccg ccgacgatga catttgtcgc tccgttcagc cacggtgcaa aaatgccgta 2450341 taccgtacct gtcacccagc ctggatcagc cgtgcaccaa taaatgtctt cttcctttaa 2450401 atcaaggacc cactttcctg tttgatattg ctgaatcatc gcttcatgga catgcaacac 2450461 gccctttggc gtaccagtgg aacctgatgt atagtgaagc agaaagccgt cttttttatc 2450521 catccattcg atatccaatc ttgtgctttc ctgtttcgct gcttcatcat aattgatgat 2450581 attcgtgccg ctctcagcct ctcccccgac tacgaagaca tgctgcaagt gaggcagttt 2450641 gtctaccggt attctctcca gcagctcagg cgttgtgaca acaacctttg cctcactgtt 2450701 ttcaagccgg tctttcaccg ctccctccat aaatgcttcg aacagcggcc cggcgatggc 2450761 gccaattttg attgcgccaa gcataataaa ataaagctcg ggtgatctcg gcataaaaat 2450821 aaaaacgcgg tccccttttt ccacatttcc ataccgtctc agcacattcc cggctctgtt 2450881 tgattcttcc ttcatttctt taaatgtgta tttttcatcc ctttttgcgt ctttataata 2450941 aagcgctact ttgttttttc gaaacgattc ggcatggcgg tcaatcgctt catacgccgc 2451001 attcagtttc cctgtctcat gccaagagaa atgtttctct gcctcggccc aatcaaaatg 2451061 ccggtacgtt tcttcatagt tttttaagtt atgatccccc tctattgctg gtaacgcttt 2451121 caagttcatg cccaaacatc cccctttgct gaagttgtca caattattat agtatatatt 2451181 catattcttc tcaattttta aaatataaac catgttgaaa acgctttata atttggtatt 2451241 cttaaagaag gcatgtattt ttgataagaa ttgatgggac ggtgaattag tggaacatca 2451301 taaaacatac cattcagcaa acatcaaaac agcaaccggc tctttactga tagaagggcc 2451361 tgtctctcca gaggatttgg caggttatga gtttcataaa gatttaaccg catttcgccc 2451421 gcctcgcgag cagcatgaag cgctagtcga cattgcaggc cttcccgaag ggcgcattat 2451481 tattgccaga gacggccgaa ccattgtcgg ctatgtcacg tatttatatc ctgacccgct 2451541 cgaaagatgg tctgaaggaa atatggagga tttgattgag ctcggagcca tcgaagtagc 2451601 gccggactat cggggatgcg ctgtcggaaa gacgctcctg accgtcagca tgatggatga 2451661 acaaatggaa aactacattg tgatgacgac agaatattac tggcattggg atttaaaagg 2451721 gatgaaaaaa gatgtgtggg aatacagaaa gatcatggaa aagatgatga atgcaggcgg 2451781 attggtctgg tttgcaacgg atgagccgga gatcagctcc caccctgcaa actgtctgat 2451841 ggcccgcatt ggaaaaaacg tcagccaaga atcaattgag caatttgaca ggctccgttt 2451901 ttatcatcgt tatatgtatt aactgacact gacaaagggg aaaaaataat gattgttgag 2451961 caaatcatga aaagagatgt cattacatta acgaagacgg atacgcttga aacagcaata 2452021 tgcaaactga aggaattcca tatcaggcat ctgcctgttg tagatgaaga acgacacgtg 2452081 atcggcatga ttacagacag ggacatgaaa caggccagcc cgagtatttt tgaagaaaac 2452141 aaacgaagcc tatttctcac acgaagcgta gattcaatta tgaaaaagga tgttgtctgc 2452201 gcccacccgt tagattttgt cgaagaaata tcagccgtgt tctacgagca tggcatcggc 2452261 tgcctaccag tggtacacca tcaaaaatta ataggcattt taacaaaaac cgatttgctg 2452321 cggacgtttg tcaaattgac aggcgctgac cagccgggct cgcaaattga gataaaagta 2452381 aacgacatca ccaaaagcct cgctgagatc agcagtcttt gccaagacct tcaagtgaaa 2452441 atattaagcg tgcttgttta tccgcatgac gatcccggtg taaaagtgct tgtcttccgt 2452501 gtaaaaacga tgaatccgct gccgtttttg caggcattac aaagaaatgg acaccacgtc 2452561 gtatggccgt cagagcaaag ggatctgcta tgagagacag tgtatttatc tattctccat 2452621 cctaccaaac ctatatgttt catcaggagc atccctttaa tcagcagcgg gttctgttaa 2452681 catatgattt gcttaagacg atcaatgcct ttgatgatgg agacattgtc acccccagac 2452741 tcgcttcaga agaggagctt tcccttgtcc acacggacga ttacattcag gccgtaaagc 2452801 ttgcgggcgc cggaaagctc cccgctgaag aaggagaaag ctacgggctc ggcactgaag 2452861 acacacccgt ctttgccggc atgcacgaag cggcatcact cttggtcggc ggcactttaa 2452921 cggccgcaga ctgggtcatg tcaggacaag ccctgcatgc ggcaaacctt ggcggagggc 2452981 ttcatcacgg ctttcgcggg agagcatcag gattctgcat atacaacgac agcgctgtgg 2453041 ctattcaata tatccagaaa aaatatagcg ccagagtgct ttatattgat acggacgccc 2453101 accacgggga cggtgtgcaa tttacatttt acgataatcc tgacgtatgc acgctgtcca 2453161 ttcatgaaac aggaaggtat ttattccctg gaaccggtca gatccaagaa aaaggaagcg 2453221 gaaaaggata tggctattcc tttaatattc cgcttgacgc ttttacagag gatgattctt 2453281 ttcttgaggc ttaccggaca gcagcttcag aagtcgccgc gtatttcgag cccgatgtca 2453341 ttatcagcca aaacggcgcc gatgcccatt actacgaccc gctgacgcat ttatcagcaa 2453401 caatcaatat atacgaagaa atcccccgtc ttgcacacac tttggctcat caatattgcg 2453461 gagggaaatg gattgcagtc ggaggcggcg gatatgatat ttggcgtgtc gtgccccgcg 2453521 cctgggccag aatatggctt gaaatgaagg gaattgaccc gggtcacgag atcccgccgg 2453581 aatggattgt taaatggcaa aaacaatgcc ccgtggccct tccgtcgagc tggagcgatc 2453641 cggctgattt atatcctccg attccccgca agcctgaaat tacagaaaaa aatgcccaaa 2453701 ctgtcagcaa agcattatat gcgatacgtt ctgaacagca aagaacaaag taaaaaacga 2453761 cctttacgaa gaggtcgttt ttgatttttt aatcactatt tccacacgcc gattttcctt 2453821 catgtgttca tttgtcttgt tatcctttac tggctttgta tccgcataac cgacagcaat 2453881 aaagcgcttg gagggaagct tctctttaga cgtgaagtat tgaatcactc cacttgcccg 2453941 tgctgctgat agctcccagt tcgacgggta tcggtatgtc gaaatgtttc ggctgtctgt 2454001 atgtccctca acctgaatgt catttggaat tgtttgaaga agaacggcaa tttggtgaag 2454061 aagtgtttcg gcatttttca gcacctttgc ctcacctgta tcaaacagca cagcctcctg 2454121 aagaacgagc acgacaccgc gttcatcccg tttggctgtc atttgggcct tcaaatgatt 2454181 gtcttttata tatgtattta ctttcttgag aagctgatcc tgctgatcct cttgcttctt 2454241 cgtatcagat ggggatgtat tctttttttc tatggatgtt tggtccggct gaagcccgtt 2454301 gccttccttc tggatcgagt ccactgccgc tttgaatttt tgcagatcga tttgggacat 2454361 cgaaaagagt aaaataaaga acacaaggat caaggtgatc agatctgtaa aggttaccat 2454421 ccagctggat gaagattgac tgttttttcc gcttccattc cttctttcaa aacgttctct 2454481 tctaagcttc atgtacagat cccttttttg tttttacttg ttttggctgc ttctgccatt 2454541 cttcccgtga gctgaaaacg accagctggc tttcaaggtt gcgcgggttt tttccggatt 2454601 gaacaccgat aatcccttcc accattacct gcttgatgaa aatttcactt tctgttttct 2454661 cttcaagctt agccgcgatc gggttgaaga ccatatttgc cagtaatgaa ccatataaag 2454721 tcgtcagaag cgcaatggcc atgtttggtc cgagcatatg cgggtcgttt aagtttttga 2454781 gcatcagcac aagcccgacg agtgttccga tcattcccca tgccggagcg aattctcccg 2454841 ctttttcaaa aactcgccgc ccttttcggt gccgttcctc cattgctgcg atttctgaat 2454901 ccatgacgag ccgaatcgtt tcttcatccc agccgtcaat cgctaaaagc agcccttttt 2454961 tcaagaatgg atctttgatt tcccgagcct gatcatccaa tgataaaagc ccgtgttttc 2455021 gcgcgtgatc ggaaagggaa acaaaggttt tcacaagatc tttcacattg tcttcctggc 2455081 ggatgaatgc ctgctttaac acagagggcg cttttttcag ctcacttggc ggaaaactga 2455141 taaaaacagc ggcgcaaagt ccccctgtta cgatgaagaa agaggtcaga tcaagaaaag 2455201 agcggaaacc gcttactccc gatcctgaaa taatcccgat aacaataata atcgttccta 2455261 acacaaatcc aacaggtgta agataatcaa aacgtttcat catttctccc catgaaaaaa 2455321 gcaagaattc accataaagg tgaagcttgc tctttgtttt tcttatgact tggttgactt 2455381 tctaagctct atacggtgcg gcagttcgac gatatgctct tcaaccggct ctttattcat 2455441 gagcttcgtc agcagtctca tcgcaacggc gccgatatca tatgtcggct gaacaactgt 2455501 tgaaagctga ggacgaacca tgaggcttaa tcttgtatta tcaaaaccga taatgtcgag 2455561 atcctccgga atggataagc cctgatcctg agcggcatgg ataatgccga gtgccatttc 2455621 atcagttgca gaaagaatgg ctgtcggttt tttatccagg ctcatcagat gctgcagtgc 2455681 ttcgagtccg gaatcatatg tgtaatcccc ttcagctaca aattgttcat taaacggaag 2455741 gttcgcttct tcaagcgcac gtttgtagcc ttggagtttt ttcgaacggt tgatcggttc 2455801 tgccattggt ccggaaacga acgcgatgtc tgtatgtcct ttatcaacca aaagcttcac 2455861 ggcatcataa atcgcctgtt cgtaatcgat agcgactgac ggtgtttcct cctgctcttc 2455921 tacagaagcg gcaagtacaa tcggcactgg agaacgctta aattccgcca catgctcgtc 2455981 cgtaatgttt ccgcccataa acacgatgcc gtccacttgt ttgccgagca ttgtgtttaa 2456041 caagtgcagc tctttctcca tgttttggtc agagttgctc aaaataatat tgtatttata 2456101 cattgtcgcg atatcttcaa ttccgcgcgc aagctctgaa tagaaaatgc ttgagatatc 2456161 gggaatgatg acacctacag ttgttgtttt tttacttgcc agccctcttg ccaccgcgtt 2456221 tggacggtaa ccgagacgtt caatggcttc caagactttt ttcctcgttg tcggttttac 2456281 attcgggttg ccgttcacga cacgggaaac ggttgccatg cttacattag cttctctcgc 2456341 tacatcgtag atcgtaatat tgctcatcct aaaaccactc cttttactgg atacacttat 2456401 ccttatctat agcataaaca ctttatgtag agaaatgtca taatgtccga atttatgtcg 2456461 tttatgattt gtaagcgtaa gtcagtagtg tacattattt ttcattattc atcaaattta 2456521 attacttctc atgaaattat acacgttttt atagatgatg aaaacgtata cttggttttt 2456581 ataactaaat aaacgagaaa gcataaaaaa aggccgcagg cgcggccttt tggattgttc 2456641 aattaagcgt tgactttcac cattggcttc agttcattca gccatttttc gaattcagga 2456701 atcgccattt gctgagcaga gtcagaaagt gcgactgacg gatcagggtg aacctcagcc 2456761 attacgccat cagcaccgat cgctaaagcg gctttagctg tcggaagcaa gaggtcacgg 2456821 cggcctgttg aatgcgtaac atcaacaaag actggcaaat gcgtttcttg tttcaaaatc 2456881 ggcacagctg aaatatccag cgtgtttctc gttgctgttt catatgttct gattccgcgc 2456941 tcacaaagga taatttggtc atttccttgt gacatgatgt attcagcagc attgatgaat 2457001 tcagagatcg ttgcagcaag accgcgcttc agaagcactg gctttttcac ggcgccggcc 2457061 gctttcagca attcgaagtt ttgcatgttg cgcgctccga tttgaatgac atcaatgtag 2457121 tccagcgctt cttcgatatg agccggagtt acgatttcac tgataaccgc cagatcaaat 2457181 tcatccgcta cacgttttaa aatttgaagg ccttcaacac caagcccttg gaaatcgtat 2457241 gggctcgtac gaggcttaaa ggctccaccg cgcaaaattt taatcccttg ttttttcgca 2457301 gctgcagcga cttcagctac ctgctcatag ctctctaccg cacatgggcc gacaatgaat 2457361 ctttgctggc cgtctccgat tttttcgcct ttgatatcaa caattgtatc ttcaggtttt 2457421 ttcttgcggg agacaagcag cgctttgctg tgatcttctt cctgaagctc taaaccggct 2457481 ttgaatatct ctttaaaaat gtgctggatg gttgaatttt cgaacggccc gtcattgttt 2457541 tcaatgatat tgtttaacat tgtgcgttct ctgacagggt caaatcggtt gacaccctgt 2457601 gcttccttcg ctttaccgat ctcttttaca acattgccgc gttcgttgat taattttaaa 2457661 atttgtaggt ttaattcgtc tgctttctgc cttaaaagct ctaactctgt gttgctcatt 2457721 tttttcatcc tttccctgca cattcatttt ttattttgta gttatcatgc atcttactat 2457781 aagtaattcc aaatggaaat actgaaatac aaaaaatttt ataaaaactc tactttatta 2457841 cccaaacgct tttaagtgat aaagtaatct atgaagctat cctacatgat gtgagggcaa 2457901 tgttcaaggg ttttttacaa aaaaaagcgc cagatgatat ctggacgctt ttttctatga 2457961 caaatgctgc tcaatagcgg cttctgtaat ttgtgaatgt gaggtatgcc atttcacttc 2458021 accgttctgg atgatgaata tctgagggct ttcatgcttg accccatatg tttctgcaat 2458081 gaaattggac agcggccggg cttcttgtac ttgaagatag taagccggca catcctcatg 2458141 ctgatttgca aaggcatcaa actcatgaaa tgctgcctgg ctgatcgggc atgtggtgct 2458201 gtgtttcaag aagacgaaaa cgccttcctg ttctgcaatc cgtttaaatt cttcctcaga 2458261 ttgaataagc tgtttagcca tgactcaagc tcttccttcc ctgctcagcg attcaactgc 2458321 tcagcctgtt tttgtgcatc tttcagttcg tcttttacat cttctttcgt ctggaggact 2458381 tgatcttttg tttcatcagc tgcctgcatc gcttcttccc tcatatcttg cattgcagtc 2458441 gatgaatccg ttttgtcaga tttggaacgg tctctcaaat cctttacctt gttcatgatc 2458501 tgtccagact gatccgctac aagctgtgtg atgttggaag ttttgtcttt tgcgatgctg 2458561 acatattgcg tgcctttttc cttcgcatct gccgtcattt tatcagtttt gtcccgtaag 2458621 gcaacagcct ggctgccgag atcgtcgcga agttctttgc ctgatttagg cgctagaaaa 2458681 agagctgtag tggcaccgat gattcccccg attaaagttc cgattaaaaa atctttacta 2458741 ttaattccat ctttgctcat cattattcct cctcttagta tttttttctc ttacagggct 2458801 gattttttct tttgcttcca tttctcccaa atttccattg ctgcttgact ccaagtgaca 2458861 acttgattga tcttatcttg attctctcta actgatgccg atacagaccc tgccgcttgt 2458921 ttcatggatg tattgaactg ctgtacagaa gctcccactc cttgaacagc atgaacgacc 2458981 gtgttcagct tttctgattt ttcctgaata tcttcagcca ggcggttggt cttatgtaaa 2459041 agctcggctg tttcagttgt gatgcccttc atttgtccct ccagcccttc aagagtggat 2459101 gcgacgtttt ttagtgtcag ctgcagtgac ttcaatgttt tagacaagta gatcactaat 2459161 acgagaaatg caactgcgat gagtgcaacg ctcaaataaa gaataataat catctcaaac 2459221 ctccttgctg caggatatac tgctgtttac ccgttttctt caatcataaa catgtgtact 2459281 gggctgtata catactattc tccgttatgt aagaaaatcc tttaataagc tttcccatca 2459341 gataaataaa aagcagtgag atcactgctt tttattatgc catgacgttt tcgtaggctc 2459401 tcatatattt ttggatatct cctgctccca tgaagatgag aacggcttta tcatgagctt 2459461 ttaaaacaga tgtgtcatct tcttcaatca gcttggcatt atgaattttt ccctggagat 2459521 caccgatcgt cagctttccg gcattctcac gggctgagcc gaaaatatcg cataaataca 2459581 cacagtcggc gccgctcagg ctttctgcaa attcgtcaag gaactgctgc gtccgggtaa 2459641 atgtatgagg ctggaatacc gcgacaattt cccgatcagg atacttctgt cttgccgcct 2459701 cgattgtcac ttttatttct gtcggatgat gggcatagtc atcaatcagc acttgatccc 2459761 caagctgctt ctcattgaat ctgcgtttga cgcccccaaa ggatttgaga gcatgcttaa 2459821 tgatgctgga atcaatttct tcataatggc ataacgcaat gaccgccaat gagtttaata 2459881 cattgtggtg gccgtacgca ggaatataaa acgtatcata gaacgtattg cggacaaaga 2459941 catcaaaagt tgtcccttcc gtgcttttta cgatgtttct ggcttgaaaa tcattttctt 2460001 cccccgtgcc ataatacaca accgggacgt tcgcatggat tttcggcaga tgctcatcgt 2460061 ctccgcaggc aataatgcct ttgttgactt gaagagccat ctcttggaaa gcgtcaaata 2460121 catcgtcaat gcttgagaag taatcagggt gatcaaaatc aatattcgtc ataatcgcat 2460181 aatctggctg atagcttaag aaatggcggc ggtattcgca cgcttcaaac acaaagtatt 2460241 cgctgttttc atttccctgg cctgttccgt ctccgattaa gaaagacgtc ggttttgcgt 2460301 tttggatcac gtgagccagc agacccgtag tcgacgtttt gccgtgtgcg cccgtaacgg 2460361 caacactcgt gaattttttc atgtagtcgc ctaaaaactt atgataacgt atcaccggaa 2460421 ttccctcaga catcgctttt tctatttcag gatgcgtgtc tgggaatgcg tttccggcga 2460481 tgactgtcat gccgggttta atattttccg cgctaaaagg aagaatcgta atatttcttt 2460541 tttcaagcgc tgtttgcgta aaaataaatt tttcgatatc cgatccttgg acagtatatc 2460601 cattatcatg aagtatttgg gcaagcggac tcataccggt cccttttatt ccaacaaaat 2460661 gataaacagt cataattgta cctccaacaa acgtctatct gttccccagt atatgacgct 2460721 catttcaatt tgcgaccgcg gcggctgaaa agcctccctt agcggcgtat tttatatgtt 2460781 ttgttatgtt tagtatcagg ttatttcttt ccgattaaac ccagatatca agatttgtct 2460841 atgcacagct gctgtaaagc ggcatagctg ttaaatgctc taaacactat cataccatgt 2460901 ttggtgtgaa aatgaaccca tattattcgt ttattaaatc acttgctgtg atcagcacct 2460961 ctcgaggctt gcttcctttt gcctcagaga tcatgccttc cgcttccatc atgtcgatca 2461021 gccttgccgc acgattgtaa ccgattctga atcttctttg caggcttgaa gtgctcgcac 2461081 tgttttgctc tacaacaaac tcacacgctt cgtaaaacag ttcgtcctct tctttcaggg 2461141 cagatccttg tcttacgagc tcttcttgtt caaataaata ggtcggcggc atttggcttc 2461201 tgacgtggga aacgacgcgg tcgatttccc ggtctgacac aaagttacct tgcagacgaa 2461261 ccggttttcc cgagccgttt tccaaaaaga gcatatcccc ttttccgaga agcttttctg 2461321 caccggctat atcaataatt gttcgggaat caacctggct tgagacagaa aaggcgattc 2461381 tcgttgggat attcgcctta atcagacctg taatgacatc gactgacgga cgctgagttg 2461441 cgacgagaag atggataccg cacgctctgg ctttttgggc gatccgcgca atgctttctt 2461501 ccacatcgtt tggagccacc atcatcaaat ctgcaagctc atcaataatg acaactaaat 2461561 acggcagctt ttcacccatt tggtgttcag cggttaattg attaaagcgg tcaatgtcgc 2461621 ggacacctga atgggcaaaa agctcatagc ggcgctccat ttcctcaacg acccatttca 2461681 aagcagccgt agccgcttta gcatcagtaa tgaccgggct gacgaggtga ggaattttat 2461741 tgtaaggggc cagctctacc attttcggat caatcagcag cacctttacc tcactcgggt 2461801 cagctttata aagcaggctt actaatattg tattgatgca tacgcttttt ccggagcctg 2461861 tagcgccggc aatcaagcca tgcggcattt tcttcaagtc gataacaaca ggatttcccg 2461921 aaatatctaa tcccagcgca gctgtgagcg gtgacttgct tgtcctgaaa gctgagctgc 2461981 gaatcatttg gcgcaaatca accaccttgc tcgtgcggtt cggcacttca attccgatcg 2462041 tgtttttccc cggaatcggc gcttcaatcc gaatatcttt agctgagaga ctgagtttaa 2462101 tatcatcgga caagttggtg attttattca cctttacacc cggttcagga tgcacttcaa 2462161 atctcgtgac agacggaccc tgggttacat ggaccacatt ggcgcggaca ttgaaatttt 2462221 tcaaggtcaa atcaagaagc tgacgctgtt cttcgatcca cgcagtatca tcttgaacct 2462281 gcgctggcgg gacatcaagc agtgcaacat tcggaaatac atagctgccg cggcgctcct 2462341 ctgctttttg ctgtttatgc gtatctcttt tcagcatcat cacattaaaa ggaacggatg 2462401 gccctttttg agaagatgcg ctttgttcag tccttttctc ctgtacacca ggcctttttt 2462461 tcggctcttc tgaagcttcg cgaggtttgt ctgcgcgaat ttcctgccgg ttttcaagag 2462521 ttgcagtaga cgatttggaa ccctgctcca tgtgttcagt tttctcaagc tctgtatggc 2462581 tgtctggctg aacatctatc ttcgtttcct gagcctctcc cagggtgtca taatgattat 2462641 ttattatgct ttctgatggc tcttctgatt cttttgccac agtttctgct tgagccagag 2462701 cctctgatga atactcatga tcagtaaata aaggctcttc ctgacgaatg tccatttgtt 2462761 cttcttgaac gaacggggac tcagcacctt ctgccgcgtt ttcatgatga ttgtatactg 2462821 ggctgtctga cggctctttt gctttttcat cctcagatac tgcctctgtc tgagattcag 2462881 gagctgtttg ctcttcatca agttcagcgg agaaaacagg ctcttcaaat ttctctggct 2462941 gctgctccct ttgttcttcc tcagccgttg caggctcttc gcggcctact tcactgtctg 2463001 aaagcccttc agccgccgta tctgtgagca tctcaggcgg tgtttgctct tcggcttgtt 2463061 cagctgggaa gaaaggctcc tctttttccg gctgttgaac gcctgactca aatggcactt 2463121 tgttacctga cggctcggct ggccgtttcg ccagcgcctc atcatgctcc gtatcctttc 2463181 tgtttaaaac gccagaaggc tgtttttcaa attgggtatc cgggaagaaa ggactttcta 2463241 ttttggaatg cgcctgtgtg tctgaagcag gatagccgcg ttcacgttcg atctcttctg 2463301 acagcagtgt taccttctct tttaccgatt tatccggttc gttcaatgtt tcagaaggct 2463361 ttttcggcac atccttttta acagatggtt tttgattgaa tccatagaca ggcgaaggga 2463421 tatttgtcgg tttaaacggt ttcttcgccg gctctgctgc ttgatatgta tgctgctctt 2463481 cttcatttct gggacgctct ctgtaaggtg cagcacttgg acgaggcgcg gatttcggtt 2463541 cgtccgatgg tgtgcggcgc cttctcaggt catgattttt gtatccgtca ggcacgactg 2463601 gaaaacggaa tttgcctttt ggatattcat aatatatttt aggatcttcc aatcttttta 2463661 attgtccttc aggatgatgt acttcttgtt gctgcggaat ttgagcgggt tttgtctccc 2463721 gttcagcatc ctcttcgctt tcgcctaaaa acaaatcaaa aaatttatga agccaactca 2463781 taatttatct ctaactccct tatagttttc tgggacggtt tttagtatac cactgctggt 2463841 cggcccagaa aagattaagc tatcagcaga aacaaagccg ctaaacaagg gcttagcggc 2463901 ttttcacatg attcgttttt tttggcggat ttatgggagt ctaaaactga aatgcgtctc 2463961 ccgcctcata gtctccttct aacacaagga ttcctttttc agcaggggca tccggcaaat 2464021 caagctcttt cgctgagcag atcatcccgc ttgacggaac gccacgaagc tctgcatcct 2464081 taatgacaag tccgctaggc atcacagcac cgactttggc aacgacaact ttttggcctt 2464141 ggtcaacgtt aggcgcgccg cagacgatct gaagcgtttc ttctcctacg ttgactttac 2464201 atacgcttaa tttatccgca ttcggatgtt tttcttttga ttctacataa cccacaacaa 2464261 acttcggaga taaatcaacg actaatgttt cttcaacgcc gtttctgttt aaaatctcat 2464321 tcacatcttg cacgaatgtt tctgagagcg caacagggcc gttttcatca atggtcaagt 2464381 aagaagacgc attgaaaatg ttgaagcccg ttgtttcttt tgtttcgtta ttgaaaattt 2464441 tgacgacgtc gccgtgtttt tcatagccta attgttcgcg tgtcacatct tgaagagaga 2464501 tcaggagcgt gtctcccaca ccttctttat tataaaaagc gttcataagt aaaaatcctt 2464561 tctaatcctt tttcggacgg cttttcgcca ggataaacac cggttccagc tttccttcat 2464621 tgtacaaaaa tgatagggcg gtaatcggga cggtgccgcc tgcaaagaag ctcatcgaca 2464681 tttgtcctag aatatcatac cccgattcat tccggatgtc agcaagaatc aaaacgtcct 2464741 gatgaggaac agagatcgcc agctcacctt ctgcatgctg cttatactca tttaagatcg 2464801 cttcgttcaa aatccggctt gcgtcgtatc cgtcgtttgc cctgaagaaa taaaagtaat 2464861 tgccggcaac cgtatcctct ttgacaaccg tcggcaggga acggagatta aatgcggccg 2464921 tctctctgat ccgctctttt gtccagtttt ctttctcaag catgcgctgg tcaattaaac 2464981 ggtaggtttt cccgagatct agcgcgtaat aaattcttgt ctctgcggta tgatcgtcat 2465041 aaatgagcgg gatatcttcg ctggacttgt ccgggaagga agtcgagcgg atgaccggat 2465101 aaatgcgagt ttctttcccg gtcatttcct gagccttccc ttccattgcc gtcatcgctt 2465161 cggagacata gtacacgatc tcatcaatgg cttcgtcttt tttcagttcc cattttgcaa 2465221 taatcggcgg caaatcgagt gtaatccctt ttttagtcgt ttgatcctca acacggaggg 2465281 tgtctttttc tctgtcaaac agaaaggagc gattctcgtg ctgaaggcgc tgcttcagta 2465341 tatctgacag cttccttgag gtcattttca aaccgatgtc ctcctttacg ctttagcgag 2465401 agagtctgtt aaaaactgtt caatttcttc ttttgttttg cggtctttgc tcacaaaacg 2465461 atttacttct tttccttcat taaacaccac aaagcttggg attccgtaaa tttcccactc 2465521 tgcacatgta tcaatgaatt tgtcacggtc tacgtagtag taggtgaatt cagggaaatt 2465581 cgcttccagt tcaggcagga aaggctctac aaaacggcaa tccgggcacc aatcggccga 2465641 aaacataaat acagaccaat catcctttac cgctttttcc agctcttgag ttgattcaat 2465701 ttttttcatt tcatatccct ccagttgttt atgttcttac atgtttttta tcgatactcg 2465761 tccatttgga tcataccaaa ctgcttgagg caaaaccact tatatgcaac gaatgaatat 2465821 gtaagattgg ctttcccatt atcattatca tattttattt gcattatcaa gctcgtttcg 2465881 tttaacatcg tgtacatgag ggtgaaattt acagatggat atacataagg agggattttt 2465941 attatggagt ttatcgtcta tttagcagga gaaatccaca gcaattggcg cgaggaaatt 2466001 aaagaaaaaa caaaatcact gaagctcccg attacgtttg ttggcccgat ggagaatcat 2466061 gaccgctcag acaatattgg tgaagaaatt atgggcgtac agccaaatgc cgttttaaag 2466121 gatgacaaag cctctgacat caacaacttc agaaccgccg tcctgatgaa taaagcagac 2466181 tttgtgatcg ccctgtttgg cgaaaagtac aaacagtgga acacggcaat ggatgcatca 2466241 tatgcgatcg caaaaggaaa acccctgatt atcatccggc cggaatcgct ccaccatcct 2466301 ttaaaagagc tttccaataa agcgaatatt acggttgaaa ccgttaacca agccattaag 2466361 gccctttcct atctatttga aacagaataa gaaaaaagct tgtcgatccg ggcttactgc 2466421 tcgttcaaca agcttttatg aaacctacat attttcttta atcgcatcca ctgtctgctt 2466481 atcgcaggct gttacaagtt tgatgagcat ttctttagca gcagcataat catcaatatg 2466541 aatgatagta gcgtttgtat gaatatagcg ggaacatatt ccgataaccg ctgacggcac 2466601 accgctgttc gaaatatgaa ccttgcctgc gtctgttccc ccgccggata caaaatattg 2466661 atatggaata tcatgcgttt cagccatatc aagaacgaat tccctcattc cgcgatgcat 2466721 gactgtcgtt ctgtcaagaa tgcgcagcaa aaagcctttt ccaagctggc cgaattcatt 2466781 tttgtctccg ctcatatcgt ttgccgggct ggcgtcaagg gcgaaaaaca agtccggttt 2466841 aatcatatga gaagccgtct gcgcgcccct tagccctact tcttcctgaa ccgttgcacc 2466901 cgcatagagt gtattcggaa gctctttacc gtgtaattcc ttcagaagtt caatgcttaa 2466961 gccgcatcca tatctgttat cccatgcttt tgataaaatt ttcttttcat tcgccatcgt 2467021 cgtaaacgga caaacaggca cgatctgctg tcccggtcta atgccgattt tgatggcgtc 2467081 ttccttatca tccgctccaa tgtcgatcat catgtttttg atatccatcg gtcggtttcg 2467141 ctgcgcatct gtcaataaat gcggcggtat gcttgaaatc acacccggaa ccggcccgtt 2467201 atctgtttga atttcaaccc gctgcgcaag caaaacttgg ctccaccagc ctccgagcgt 2467261 ctggaatctg agcagcccgt tgtctgtaat ggatgtcacc atgaagccga cttcgtccat 2467321 gtgcccggct accataattc tcggtgcgtc ctctgcgcct cgtctgactc cgaaaacact 2467381 tcccagtctg tcctgaacga tgtcatctgc atatttggct agctcctgct tcataaaagc 2467441 acgaacctga tgctcattgc ccggcgcgcc gggaagctgc gtcagtgttt ggaaaagcgc 2467501 tttcgtttct tgattcatgt tttcccctca tttctatgta gtccttttat tttattagaa 2467561 acaatgaagt tttccaagca ctctgaccca atctgctcga tcagccgcgt attgcttaac 2467621 aggatttggc tgtttctgta taatgaaaag tacgatcaac caggaggtgc tttattttga 2467681 aattgcgtca tcttctttta ggagcaggac ttggaatttg tacggctgtc gttgtgagac 2467741 aatatgtgat gaagccttat atttcttcag aaaaagcgct tcgaattgta aaatctgctt 2467801 ttaagcagcg gggcccgatt gacggatcat ggatttacac ccagccggag ccctacaata 2467861 ttaacggaga aacggtacag gtatacaaaa ccggcattac acgatcagct ttcggagaat 2467921 tagaacagta tgaagtcatg gtggatgcga aaacgggaga aattgttgat gtcattgata 2467981 caatcgcctc ttaacaccgg acaagcaaaa aatagaagcc gctgcctatg cagcggctct 2468041 tttttattat atcgcgcgaa tcggtttgta taccggatac cacatcgcat cctgcactgc 2468101 ctgtataatg tcttcaggct cttccgtagc gacgccttcc ttcattgcgg tttttgcaac 2468161 ttcaacagca acggttgccg aaacagtgcg caaatcttca acttttggaa gcatcggcgc 2468221 cccaggcacc ccgacattga ccatacctgc gattgcccgg gcacatgctt caaacatgcc 2468281 gtcggtaatt aattttgatt ttgtaacaat cgttccaaga ccgagaccag ggaagacaag 2468341 cgcgttgttt gcctgcccga tatgatacgt aactccgtta tattcaactg gcgggaacgg 2468401 gcttcctgtc gtgatcagcg cacggccttc tgtccattcg attaaatcct ccggctttgc 2468461 ttcagaaaga gttgtcggat ttgacattgg caaaatcgcc ggccgtttca catgtgacgc 2468521 catttctttt acaatttctt cagtgaaagc gccggaaacc gtagatgtgc cgatcaggat 2468581 cgtcggtttc gcctgccgaa ccacttcaag aagatcaatg cctccgccgt ctccgttccg 2468641 ctgataatcc ttcacttcat cagccgaacg ggcatacggc ttttggaaat caagaagctg 2468701 atccatatca tctgttaaca gcccgttcct gtctatgcac cagaagcgct tgtatgattc 2468761 ttcttcactc agtccctcgc gcaccaatgc ttcccgcagc tgttcggcaa ttccgattcc 2468821 tgccgttccc gctccgaata taacaactct gtgatctctc agcggaactt tagacgcttt 2468881 tgcacaggat aagactgcgg ccaaagaaac agcgccagtt ccttggatat catcattgaa 2468941 ggtacacact ttatctttat agcgtttcaa aatgcttcgc gcgtttttcg ccccgaaatc 2469001 ctcccaatgc agcaatgcat tcggaaatgt ttctctcgcc agcgcaacgt agtcgtcaat 2469061 aaattggtca taacgttccc cgcgcactct ggaatgctgg ttgccgacat aaagcgggtc 2469121 gttcaagagg ctctcctgat ttgtccccgc atctaaaaca acagccagca ctctgctcgg 2469181 atcaatgccc gcagccgctg tataaaccgc cagcttgcca atagaaattg cgattcctcc 2469241 gacgccccag tcaccgattc ctaaaattcc ttccgcatca gttgcaacaa ttaaatcgat 2469301 cgtatcgctt tgatctttat actgtttaaa agcttctttc ataccgtccg ggtcatcgat 2469361 tgacagatag agccctcgtg gttttctgta ttcatggctg tatctctgaa ttgccgttcc 2469421 gactgtcggt gtgtagacaa tcgggagcat ttcccctaaa tggtcattta acaggcggta 2469481 aaacagcgtt tcattccgat cgtgcagcgc cgttaaatag acatttttgc tcaaatcgtc 2469541 aggctgtgcg gaatattgtt catacgctct tttcgcctga tcatcaattg ttaatacctt 2469601 gggcggcaga aagcctttta aaccaagttc ttttctttct tcctcagtaa aagcaacacc 2469661 tttgttcaaa aaaggaacag agagcacttc aaggcctctt aatgttgttt gaatgtctcc 2469721 ttcgtttgtt actctgaatt gtttcaccct gcctcttcct ttctgagcat aatagtacta 2469781 ggtttgcatt attagccgga aaacatgcag ggtaaacata aaaatatgct atcgcttcat 2469841 tcgcttaact gactttttga tgcttccgtc ctcctcccat tgaagggcgc gatactcggc 2469901 atcatggtaa aaaataaacc aagcatcttt ttctgctgcg aacgcctgcc atttctgctt 2469961 ttgcgggata gaggtcatcg gataatcatc gtaagccagc acccatagcg gattgcggtg 2470021 ggcatgtgtc ggcatcagat ctgccatatg tacggcagtt tcacccgcat cctcgcatat 2470081 caggacactg tgtccgtcgc tatggcctcc ggtgtgatgc attgtaatac cctctgtgat 2470141 cgttaaggtg tcttcaaagg ttttgacttg gccagctaca gcctcccaat tttctttcca 2470201 atacgtattt ttcgacctga tattcggatg gcgcatttcg tcccattcaa cagctgatgt 2470261 ataaatcact gcattcggaa agacagagac gagccgttca ccttcatatt ccgttaaacc 2470321 gcatgcatga tcaaaatgaa ggtgtgtcat tgcgatcaca tctatatcgg caaccgttaa 2470381 tccgagtgca gctaatgagg gtttcacatt cgactcttgt gtcacgccat agtttcgttt 2470441 ttgtttatca gtcagcttgc cgtacccaat tccggcgtca atgatgatat tgagcccatc 2470501 cttttgaatc aaaatagggt ctgttcttag ttcaatctgg tttttttcat tgactggata 2470561 ttttttagac caaagcggct ttggcacaac gccgaacatg gcgcctccgt ccatatgcgt 2470621 cacgcctccg tcaagccagg tcaacgtgat gtttccaatt ttcattgttt ccattttcac 2470681 ccccccctat catcatggta gcaaacggcc cataaaaaaa acagactcct gtcagagtct 2470741 gtctttacgt tctccattca acctcagccc gatagatcgg ctggccgagt gcagagaatt 2470801 tttcttcata ttctgtcata atattgcctt ccagattgct gttatgcaaa tcgagactga 2470861 cgtatgtcag caggaggccg tactcagaga agctcttcaa agagtactca aataaacctc 2470921 ggttgtccgt tttaaaatga atcgatccgc ctttgcccat tacttcttca tattttttga 2470981 ggaagtggga atatgtcagg cggcgttttt catgccgttt cttcggccaa ggatcagaaa 2471041 agttcaagta gacccgtttc acttcccccg gctcaaacac atccgtcagc gtgtccgcat 2471101 ctatattcag aagctttaca ttctgcgctt cgctgtcttt tactttttgg acggctgtca 2471161 cgatgacgct tttaaataac tcaataccaa tataattgat gtcgggattt tgtttggcca 2471221 taccagaaat aaattggcct tttcctgtac caacctcgat atggatcgga ttgtcgttgc 2471281 caaacactgt gttccatttc cctttataat cagcaggatt gctgatggca atatctgcgt 2471341 tttcagccaa aaagtcatca gcccaaggct tgtggcgcat tctcatatga ttgacacctc 2471401 tatctattat ttcgactaac aacataccat gaattaaaaa gacccgcaag ctcgtttttc 2471461 cagtgtatct ctcttaaggc cgagcgcata aaaaaagagg gtcccgtctg ctggaacact 2471521 cctttcccat gtataaaaac gctctgtttt gaacaattta acccgtatga tactgaaggg 2471581 atgtgtaccg ttatgggttt acattatgag catcaagttc atttattgaa ggatatattg 2471641 actgaccatc aattggactg ctgcggaaca gtcgcagagt acgagcagct tgagcgtgtg 2471701 attaaatcac tgatggcaaa caccgagctt gattcaaatt tcaaaaacgt gcttgaagat 2471761 gtttaccgct acagccaatc aggaatatcg tccaaatcca tcgactcaca catacaagag 2471821 catcagaaca gcctgtctca atgggtagag caaatggatt cgtattcctg attaatcaac 2471881 aattcgtttc atgaggatat gcagctcttc cattgcatca tgaaattcct tatcattgcc 2471941 ttttgcttta tgccaggcaa tgaaagtaat tgtttcagat aacacatacc aagccattcg 2472001 caaccgaagg ctttctgtca gctctatgcc gtacatgctc agccagctct cccaagctgg 2472061 cttttcgacg tagtggtaca gcaaaggccc gaggtccatc gccggatcag cgatcatggc 2472121 gccgtcccag tcaattaaat acagctggtt gtcttcagac aatagccagt tattatgatt 2472181 gacatcacaa tggcaaacga ctttctcacc gaaatgcact tcatgcaggt gttcttccaa 2472241 atacttgatc ccttcttgaa tcagcggcga agattgctgc acagcaaata cagcctgctt 2472301 cagctgagac aaaagagccc ccgggttcag cggttctttt ccaagtctct tcagcatgtc 2472361 cagcaaggct tttgatgtgt gtattttacg aagcaattca gcaacgggcc gtccgctcat 2472421 gtctttaggc ttcagctctc tgccggtcat ccagtgctgg gccgtaatga cgtccccatt 2472481 ttccatccgt tttgtccaaa ccagcttcgg aacaatgcct tcggcggata aaacagctaa 2472541 aaaaggtgag ctattacgtt ttaaaaaaag ctgctgcccg ttatgtttcg cataatatgc 2472601 atctcctgta gctcctccgg cggggaagat ctcccaatcg ctacctagta attgtcccaa 2472661 ccagttcata tcaatgttca acccatcatt tcttaaaata ttttagaatt aaggctaatc 2472721 gtttctagtc tatccagcga atgccttttt cgtacgaatc gtataaaaat aaaaaagaca 2472781 gctattgaga gtctcatatg ctaatcaata gccgtccttt aaattttagc gctatagcac 2472841 aaacttcgtc aagcaaaact cttaagatct gatgctaaat ataagataac cgttccgatg 2472901 ccgtttactg caaccgtttt cttgatttct gttgggtctt cctgaaatcc tgatggatca 2472961 cataaaagcc gataaggtat gtcgtttggc agcctccact cgacggagtc tggactcgcg 2473021 tgatggataa caatgatatc tttccattcg tcaacctcgt caagatcata aagcctgtat 2473081 gcgataaggt gttcttttag cgtcaagcat tcaagatggc gctggatgtc tgcagcggac 2473141 ctaagacgga atgcaggatg cgcttttctc agcgagatca gcctgcggat atagtgaaca 2473201 tcttctttga atgtttcacg gcgatcccag tcgagctggt tgatgctgtc actggattga 2473261 tagctgtttt ccactccctg cttcgtccgg aaaaattcct ggccgctgtg aataaacggc 2473321 accccttggg caagcaaaat aatcgcggct gcaagccttt gcctgcttcg ctttcggctg 2473381 tcattttctt gaggaagcgc aaagctcatt ttatcccaaa aggtgtgatt gtcgtgtgat 2473441 tcgacataat tgatggactg gcttggttcc ggaacaatcg gtgctaatgc cttccatccg 2473501 gaagacccgg caattccatg catcacagct tgtgctgatt caccgttgcc gagcgcaaac 2473561 cctgttgcct taaggtgaaa ggtgttccct tttacagcgt cacgaaacat atcattaaaa 2473621 aagccgatgc ccggcattct tggcgcgttc gccaaagcag ctttctgttc atgcggcagc 2473681 ggtgtagcca ggtcccaccc ttctccaaaa agcaggattc cgggctttgc cttagttgct 2473741 ttctctttca tataaagcac ggtgtcaata tctaaaatcc cgaggagatc aaagcggaag 2473801 ccgtcaacat tgtattcttc aagccaatag accacgcaat ccgcaatgaa ttttcttgcc 2473861 atccttcttt ctgatgcaat atcattgcca acgccggtgc cgtttgatgg catcccacat 2473921 tcgtcgtgcc ggaaaaaata accgggcact gtcttttcaa agggggaatt ctccctctta 2473981 tacacatggt taaaaacaac atccagaatg actcgcagac cgtgctgatg cagggtattg 2474041 atcatttgtt tcagctctgt ttttctcgtt tgaggatcat gaggatttga ggcatagctt 2474101 ccctccgggg caaagaaatg aagcgggtta tatccccaat tgtatgcatc aagcggcttc 2474161 tcttcatcaa ctccggcaaa atcattcacc ggcagaagct ccacatgtgt cacaccaagc 2474221 tcttttacat acgctaatcc cgaagaactg ccatttgcgg tttgtgtatc agtttccgtc 2474281 agcgctaagt attttccctt gtttatcatg ccgctgtttt catggatgga gaagtcgcga 2474341 agatgcgtct catagatgac ggcatccaca gggtgtgaga atggtttaag aggagcagtc 2474401 catttcattt gatccgggcg caagacgacg cccttctctc catttacagt cacagccttg 2474461 gcatactggt caactgtttc catccattct gaattgttgc agatgcaaaa caaatactca 2474521 tatccgtgaa ggtcacctgt gaccgtgacg gcatagacgc ctttttccaa gcgagtcatt 2474581 tggaatgtgc gcccgctttt attggggtgt gaaagcttga cagcagctga ggttgcagca 2474641 ggcgcccata ctttaaatac ggtatgatcc gcggtataaa cggcgcccag ctctccgtca 2474701 taataaaatt cgtcatcaaa cgctgccgtc cggatgaccg cgccaatttg gagatccgtt 2474761 ttgtggccgc tggatgctct gacgcaatgg atttttccaa atgtcacagg atggtcggat 2474821 acgcagacgt acttgtattt tgcttcaagg gagtattcct ccctgacagc cagaggaaaa 2474881 tctgttattt ctgtctcaag ccgaaacggc ggtgtcatga tttccttttg ttcagcagga 2474941 atcagaacag taatgatatt catgtcatcg acatacgctt cgaagctgcg gcggatgctg 2475001 accatcggaa gctctctcct ccaaacacgt ttatgttttg attcttaggg gtgaaggact 2475061 agatgccaga cgaaacgggg tagtgcccat gatttctccg tcagcatgga acgggatttt 2475121 gtccttcgtg taaaatgtaa tgtccttcgc tttaaacatc gtaacgccat ccatctttgt 2475181 atgttttcca aatgccatga gacataaaag ccaatatttt ttcaaaaacg gctggttttc 2475241 aacgattacg atatcaaatg tcttctcgcg cggatttgct aggggcgccg ccttcatgcc 2475301 tcccccgtaa aacggatggt tggatacaac ggcaaaccag acatcatgaa attcgcgcgt 2475361 ctcgtcttcc gtcgtacaag ctaatgtaaa cggcttaaag gttgccgaag cgtgcaaatg 2475421 agaaagcgga tacacaagaa atcgaaggcg gagaaaaaga aaaacccgtc tcaacggaaa 2475481 ttccatcgcc tttttattga catatgcgtc aaacccgatc ccgatatgat tcataaaata 2475541 aagaatctgt gatttatcct gaaggaaatt gacgctccct aaatgaaagg ttcttgttaa 2475601 cgggcgcttt accttcttga tttcctgtat cagatcgatt tttttaatag agaaccctcg 2475661 cgaaaaatca ttatacgcgc ccgccggcac aaagctcagc tcaatatcgt caacatcttt 2475721 cagcccgttg acaacttcat gcatggttcc gtctccgcca atgacgatca ggcgcttcag 2475781 cttatattcc tgtatcgttg aaatctgtct ggcgagcacc tcggcgtgtc ccggatgttc 2475841 agttaaaaat gaacggtgct caacctttcg tttgatcaat tctttttgaa tggacttcca 2475901 aacacgcagg ccgtttcgat gtcctgctgt cggattaata ataaaaaacc aatggctcat 2475961 ctttctcacc tgcttatgtt atgagaaaac cgctcaaatc gttctctttt actccagcca 2476021 ctcctgtctg cgataggagt cagacatgca gtaagacaat agagcctttg cagcctttac 2476081 ctgatgatgt ttgatcggag cagtgttttt cttctgccgc tcaatccatt cttccgcgct 2476141 ccgcttatcc gctatttcta agccgtatgg cggctccggg taatcgatgt acgacgttct 2476201 gctcagaagc aattttcgaa ccggaatctc agcctgtttt tcctttacga tctttgacac 2476261 aaccgagtcc gtacgaaaca ggctaagccc tggatttaac actgatgcag tctgagaggc 2476321 tgttttcttg tcccaaaaac gatttttaga ccctatgtag acactgtctt cctcagcctc 2476381 taaaaaagaa acgcaataaa tttccagagg agaaataatc acaatgctta attcaaccgc 2476441 cgcctgctga attttcagca caggcttata cataataaaa taagaatcag gcagctgctg 2476501 ggtcagataa cgcaaaatgc ggtcctgctt cacttggttt gagagttgag atatttctga 2476561 aagagtagag cttgcccatt tgagctgaaa atcatataaa tgccttttat aaaaagaagc 2476621 aagcgccacc ctgctcttcg ggagccttac atgaatatct tcttcgtcct caaaccattg 2476681 gtgtctctct tcttgtatat cggcttttat ctcttctttt cttcttttca atgaaaattt 2476741 ttttcgtttc tgcaccggtt ccggttcttc agcactggct tgcctttctt catgctggcg 2476801 ctccgctgct tctactagtg aaagccagcg ctcttttttc aaacgtacaa actggttgat 2476861 ataatggtac ggatcaagct catatctcga tatataatca tgaattttga tgatttgtgc 2476921 catgtttgtt tctccactcc gcaatgaatt aagataattg aaatttgaat atttcctcgt 2476981 attttggtga ttggttcaag tgtatttgaa agagcgaaaa tcgttcagcc atcatcgaaa 2477041 cctcgccgct ttcaaacgga acatgagctg gaaatccatc ttcgcctgtc cattttcttg 2477101 ccagcgtcat atgaggatga tacggtcttt tttccacttg aaagccggcc tgaagtacag 2477161 cctgcttcgt atgttcccgc agtctatcaa gcgttttgtt tttctttggc tccagatgta 2477221 aaacgcgcgg ctttctgcgg tcgccgaata catctatctt gccaaactta attgaaaatg 2477281 gatcaatttc tgaagcaatc tctgctagcg aaccttcaag cttctttatt tgtgtctcat 2477341 ccgccgctcc gagaaaaatt aacgtgatat gatagtcaag cgggtgcacc catttttgaa 2477401 acgtcaatat cggttcgttt ttcgcagcct ggtagatcgg atttgcaatt ccctcaggta 2477461 tgggaacgcc gatgaaataa tgaggccgta tatctggcat ccgtctgaca ctcccttctt 2477521 tgacagctat tattttatca ataaagaggc tgtgcggata gaggaacagt gtatgaaaac 2477581 actctcgcac aaacgtttat tatgttagga tattatatga cacttgtttt attcagaaag 2477641 gaatgacaat gttgaaaatc gttgcaaaca cagctgatct gataggagat acaccgctag 2477701 tgagattgaa tcggcttcag ccggaaaatg cggcacaagt ctatttaaag cttgaatttt 2477761 tcaatccgag cggcagtgtg aaagacagag ccgcttatca aatgatcata gaagctgaac 2477821 aaaacggttt actcaagccg ggatcagtta ttatagagcc gacaagcgga aataccggca 2477881 tcgggctcgc catgaatgcg gcagcacgcg gatataaagc aatcttagtt atgcctgata 2477941 cgatgacgaa ggaacggatc aacctactta aagcttacgg tgcagaggtt gtattaactc 2478001 ccggagagga aagaatgccg ggcagcatca aaaaagcgaa ggagcttgcc gaacaaattc 2478061 cgaacagcta tattccaatg cagttcgata acactgctaa tcctgatgcg caccgaaaaa 2478121 caacagcgcc tgaaatcgcc cgggcaatag aggaaatcgg aaaaccgctc ggcgcttttg 2478181 tagcctcctc tggaacgggc ggaaccatta ccggaacagg tgaggcgctc aaagagcttt 2478241 ttccggatat cacggttcat gttgttgagc cagcgggttc gcctgtatta tccggcggaa 2478301 aacctggcgc gcataaactt gtaggaacga gcccaggctt tataccgccg attttaaatg 2478361 aagacgttta tgatgaaatt atcaaaatct ctgatgaaga cgcgtatacg acgacaagac 2478421 ggcttgctgc tgaagaagga attcttgtcg gtccttcatc aggcgctgcc tgcttcgcgg 2478481 caatcgaaac agcgaaacgc ctctctcctg acaaagttgt ggtctgcatg acagctgata 2478541 caggagaacg gtacttatca actgatttat ggtcatttat ttaaaaaaag gactggcttc 2478601 agcagaagcc ggtcctttta ttttgcaagc tcgtaaatgg cctgagcata taacgctgtc 2478661 gatctcagca ggtcatcaat ttcgatatat tcatcctttt ggtgtgcgct gtcagggcgt 2478721 ccggggaaca gcgggccgaa cgcgacaccg gcttttaagg atctcgcata agtccccccg 2478781 ccgattgaga ttaaatcagc ttttttaccc agctggcctt cataaacctt ttgcagggtt 2478841 ttgactaacg gatgatctgc ggacacgtga tgcggcttgc tgtctttgaa ttctcccagc 2478901 tcaaattcag atgcgctttc gaatgtatcg cggatcactt tgctttctgc tgtcacagga 2478961 tagcggatat tgatcccgag ctcgcctcct tgcccttctt tatagcgcag tgttccgaca 2479021 tttaatgtca gctctccgct gatttcatcc tcacagtcga tgtccagttt ttttcctctt 2479081 gtatcacctg agaacttatc tgtcacaact tgcacaaacc gctttcctgc atcgtcaagc 2479141 tcagtctgct ggagaaattc gcacaataaa atgccggcat tgatcccatt gttcggttcc 2479201 atcgcatggc aggaaagacc gtacatacgc aaaatgagct gtccgttctc tattgcagct 2479261 tccccttttt ggtccgtcgt gcggagcatg tctttaaatg aagacagaat ctcttcattt 2479321 ttcggccctt caatgacagc ttccgcagcg tcgggcacca tgtttaagcg aaggcctgat 2479381 tgaaacgaga caagcactgc ctttggttca gcttgatttg ggcggtgcgg aataagtaaa 2479441 gaagcatcga tgatcccttt ttccgcatta atgatcggaa aatcggcgtc aggcgcaaag 2479501 cccattgttg gcatttcttc atgcttgaaa taatgctcta cgcatctcca atcactttct 2479561 tcatctgttc cgataatcat tctgactcgc ttggacaggg gcaaattcat gtctttcacg 2479621 attttcagcg cgtagaatgc cgccattgtc gggcctttgt catcaatggc gccccttgca 2479681 taaatccgtc cgttgcggat ttcagctgaa aatggatcac tcgtccaccc atctcccggc 2479741 ggcacgacgt caacatggca aagtacgccg ataatgtcat cgccctcccc ccattcaata 2479801 tgacctgcga agccgtcaag attttttgtt gtaaagcctt ctttttctcc aagctccagc 2479861 aatgaagtca ggctggcatt taccccttct ccaaacggtt taccgggtcc ggcggttgtt 2479921 tcgtccatga cactgttgat tctcaaaaat tcctgtgtat cacgaattaa atcctctttt 2479981 tttctgatca cttcaacttc ccagttcata atgatcccct ttccgcaaga aatgacttgc 2480041 aaaaaccaaa taaaacgaat aatattaatg gtgttttgtt aaaacgttcg taattggagg 2480101 atactatgtt tcatctaaaa gagcagcaaa catccataaa gcaagaaatc atagcagggc 2480161 tgacgacctt tttcacaatg gtctatatcg tcgtggtcaa tccggtcatt ctggctaacg 2480221 ccggggttcc tttcgaccag gttttcaccg caacgattat tgcctccatt gtcggaacgc 2480281 tgtggatggc cctggcagca aattatccga ttgctattgc gcccggcatg ggcttgaacg 2480341 cttatttagc ctttcatgtc gtaagcgcaa gcgatggcgg catcacgtac gcaacagctt 2480401 tcagcgcagt atttacagca ggggttctct tcattattct atcgttaacg cctttaagaa 2480461 aacaacttat agaagcgatt ccaaacaatt taaaatacgg gatcacaaca gggatcgggc 2480521 tgtttattgc ttttatcggt ttgcgtcaag cgggaattgt ggcagctgat gagtcaaacc 2480581 tggtcactct cggcaatctg cattcacctg gtgttatctt aacgctggtc ggccttttga 2480641 tcagcgtggt cctgatggtg ctgaatgtaa gcggcgcttt atttatcgga atggcagcta 2480701 ccgctttgat cgcctttttc accggtcagc tccatttttc aaagggattt atgtcgcttc 2480761 ctcatttgcc ggaaggattg atgatctcaa atccatttac cgcttttggc gatgtcattc 2480821 atcacggcct gtacgctgtc gtcttttctt ttctattagt caccattttt gatacgacag 2480881 gcacgatgat cggagttgcc gagcaagccg ggctgatgaa aaacaacaag ctgccgaacg 2480941 tgcgaaaagc gctgcttgct gattcaaccg cgacgacagt aggagctgtt ttcggcacaa 2481001 gtccgacgac tgcatttatc gagtcttccg ccggtgtcgc agccggggga agaacggggc 2481061 ttacggcttt gactgtcgcg gtgatgtttg cggcttcaat gtttttcagt ccgcttgtca 2481121 gcgccttgtc aggtatagcc gccatcacct cgcctgcttt gattatcgtc ggcagcctga 2481181 tgatgggctc agtttccaat atgaactgga aagagatgga cgaggcattt cctgcgtttc 2481241 tcgtcattct agccatgcct ttgacctcga gcatttctac aggaatcgcg cttggcttta 2481301 tttcgtaccc aattgtaaaa gcggcgcggg gaaaatggag agagattcat ccgctcgtca 2481361 tcgttttcgc cattctgttt ttcatccagc tgtttatttt ataaggatag accaaaaaac 2481421 ccaaacgtcg ccgtttgggt tttttatgta aacaataaag agacagcggc cgctaaaaaa 2481481 caacaggcgg caaacgcata gtgcaggatg ttgatacagc tttttctggc ccgataatat 2481541 tcatcacttt ccttatcggt gccaattaaa aaaggggcat ccatgacctt gtcaaaaata 2481601 agcgtcagga tataacggca aacccctgtg tataccagca gcgcaatcac cttcagccaa 2481661 attggggaaa caaatatgag aacagtgaaa gctgacagta gcatgtacat ctgccttgca 2481721 tactcgccat tcctcagcat aactttaaaa aacaactcct tatagcctgt gcagatcgtt 2481781 cgtcttttaa atatcctttt tgaatttcgg tataataatg gttttcttct catcctgtct 2481841 tttacttttg gcattcccgc ctcctgactc atcatcatca caagtcctgc aagggcaagc 2481901 ctgctttttt tctcttcagt cacctcagct tcaaaagccg tgaacgaggc tgtctttttc 2481961 aaactgcgga taactgagaa aaacaaaaat aaaatgccaa aaagcgcaag caagtgccgc 2482021 tcagtaaaaa caatcaggat agcagaacca gcaaaaagaa tagctctgac aagggtatcg 2482081 ccaatccatc tcgaaatgga gcgcggcttt ctgatcctgt cttgctttaa ggataaaaag 2482141 aatatatgaa ggccaaacaa ataacacaat agagcagtgc tttctgcgaa tgtgatgaga 2482201 acagaatgac tgatcaaggg aaggacaatg aaaaagagaa gcagccattt agccagcgtg 2482261 gccagaaaag aatacaaaag cgcataccgt ttgagctgat agatgatttc cttcttttgc 2482321 agcaaaaaca ctttgtccgc ttccattaaa aatgtacgaa tcgaacctgt aaacatgatc 2482381 agcacacaca cagcatacag ccatctccat tccgccactt cagaccactc ataaagaagg 2482441 cctcttccgt tcatcaaatc aatatactga tagatgacaa aagcaatcgc cggcaaaacg 2482501 atatagagag cgactgtcca gtcaatgacc gcatgcaaca ctttaaactg atacttataa 2482561 tagtcaaaca gccttcgaaa aaagagcgta cgcccgttca tagccgatca ccttgaactg 2482621 ccttataaaa acagtcaagc aatgactgcc cctctaatcc ggtcttgtcc tgaacatctt 2482681 ttaacgtgcc ttggagaaat aatgaacctt tctcaatcat ataaaaccgg tcacagattt 2482741 tttccgcggt atcgagtaca tgcgtgcaca taagaattcc ggctccacgt tctttttcag 2482801 ccttaagcat gtccacaaag cgtttcgtcg atatcggatc aaggccgata aacggttcat 2482861 caatcacata catatccggc ttagagagaa aggcctggat aagcattagt ttttgctgca 2482921 tgcccttcga aaaggtgaca ggcagctcat gtttgacatg atctagcgaa aacgtctgca 2482981 gcaggctttg ggcccgatgc gcaaattcac tctcttcaat gccgtgaagt gtgctgatca 2483041 gatccaaatg ctcccacagc gtcagttctt cgtagaagga cggatgctcc ggaatatatg 2483101 caaatgaaca gtcgttccag gcaatatgcc ctttaaaatc ttctgaaagg ccgagtatcg 2483161 ccttgattgc ggtgcttttt cctgcgccgt tagctccgat cagtccaacc agttcccctt 2483221 ttctgacttc cagaaaaaca tcggtgagca ctttttttcg gcttgtatac ccggcctgtt 2483281 ctattgaagc ttcaagcaaa tttgtcaaaa ctcactcacc tccaaaattt actacgaaat 2483341 agaataaaaa aagtttcttt aaccataata atattgagcc gaaatacata gtaatccaac 2483401 aaggatggct gcccaacgcg aaattggaaa aaattaatag gagttatccc tagattcatc 2483461 actgcaatat cgtgtataat gagggcgaat tattttaaca attacagatg tctgcctttg 2483521 ttgctatttc gtacgcagtt gatagtcgtg agttgtggtt agtcaagtcc atccgatctt 2483581 atgataggga gtggtttttt gaaaccttca acaaaccgta tgctaactcg aatcaaatca 2483641 gtttacatgt ttattcaaga aaaaggtctt gtgacaacac aggaactggt tgacgaattc 2483701 ggcattacac ctagaacgat tcaaagagac ttaaatgtgt tggcatataa tgatcttgtt 2483761 catagtccaa gccgtggcaa gtgggagaca acgagaaaga aagtaaagat tacctcataa 2483821 attgaaaatt acatagggcc gcctgagagc ggtccgatag ataacagggc gaagaaacta 2483881 ctgagccttg tttttgtgtg cttataaata aaaccccgca ttcggtatgc ggggtttttg 2483941 tcatgcttgc ggctcattta gcaaatgaag ctcttcctct gtcagctcac ggtattctcc 2484001 gggtgccaga gcgggatcta gggaaacgcg tcccatcgaa agccgcttca gataaaccac 2484061 ttcattgccg actgcctttg ccatttgctt gacctgatgg tattttcctt ctgtaattgt 2484121 cagatatata acggtattgc cactgtcgtt tgttttgatt tccgcttttg ccggctttgt 2484181 tttatagccg ccctctatgt agacacccgt ttccaaatcg gaaatgtctt cccgagaaat 2484241 ctgtgatttt aaatggactt catacgtttt tggaacatgc tttttaggag aaaggagccg 2484301 atgtgcgagc tggccgtcat ttgtgagcag caaaaagccc tctgtatctt tatcaagcct 2484361 gccggctgga aatggctcaa atctcatctc ctccggcgtc agcagatcga ccactgtttg 2484421 ctgccggctg tcctcagtcg ccgacagcac gccctgcggt ttattcatca taagataaat 2484481 gaactctcga taatcaaccg gttccccgta tacggtcacc tcctgcgtat caggatcaac 2484541 gtgctccttt acatctttgg caggtttgcc gtcgatcatc acggctccag ccttcacaac 2484601 ggctttgact tcttttctgg aaccataccc gctgttggca agcagcttat caagtctcat 2484661 tcccaatctc tcctttataa aagaaagccc gcagcatgcg agccctcagt ttcatcatat 2484721 ctagttcatc agcctgcatg tctgcctttc ctaaagaaac ctggcaaacg gcggcctaaa 2484781 attttctgca aaaatcctaa tcggtagccg caatacaggt agacagctcc gccaacagcg 2484841 gccgcgatca ccacaacaat cgcagcttgc atctggccat cctgatagga aataaagaag 2484901 cctaataccc actgcacgat tttcacggca atacccataa tggctgataa gaccagcatc 2484961 aaaacagttc gtttaacaag tatcttatac gaatagcctg catggcgctt aatcatgata 2485021 aacccatata aaagggaagc gatatatcca agcgccgtcg ctaaaatcgc tccgtcagcc 2485081 tgcatcagct tgatcagcgg aacattcagc acaagcttga tcacgacacc gatcacaagg 2485141 ctgacaaccg caaatttttg cttattgatg ccctgcagaa tagctgcgtt gactgtaaac 2485201 aaagagaaca gaattgcgac aggcgaatac caaagcaaaa tgtttgcccc cagttcagga 2485261 tgaaggctct ctgacccgta aaagaacgta tacgtcggtc ctgacaatag agagatcccg 2485321 acaacagccg gaataattaa aaacaggatc gtctgcatcg tttgattaat ctgctgattt 2485381 aacagcttat agtttccgct tgtaaacgat tcagtaatcg ttggaattaa tgtcagtcca 2485441 aaagcagttg ctagggaaac cgggatcatc acgagcttct gaacatacag ggttagaatc 2485501 gcaagcatgt cctggctgat ggcttgatga ccggcttcaa tcatcgcttt gttaaacgta 2485561 tttgtatcaa tatagttata caaagggatg gctagtccga caaaaacgta cggagcagca 2485621 tagctgaaca gctcgaaaaa cattttcttg tagcttaggt ttgctgtcgg acccgtattc 2485681 ggcatcatcg ccagcaggct gcccttccgt ttgttccaat aaatataaag cacgaccagc 2485741 cctccgaagg caccgatcag cgctgcgaag gttgcatagc ccacagcgat gacaaggccg 2485801 ccgttgaaaa ccttcaaaat caagaatgtc gcactcaata gaaagatgat gcggacaatc 2485861 tgttcaacga cttgggaaac agctgtcgga cccatcattt ggtgcccttg aaagaatccg 2485921 cggacaaggc tcataatcgg tacgaccaaa agcgctaagc tgaccatgcg gatgacataa 2485981 acgacatgat caattgtcag gccgttatta tccttgcctc ccagcgatat ttccgcaaac 2486041 atcggagccg atagatacag aatgaaaaag gctatcattc ctgtgactag cataaccgac 2486101 atgcccgcct tgagcatttt cctgcttgtc tcataatccc cttttgaatt atatttggaa 2486161 acaaatttag aaacagcggc cggaaagccc atcgtagcaa tattcaaaaa taaagtgtat 2486221 tggttgtatc cgtattgaaa taatgcaccg cctgtcgccc cgaccataat gctgaaggga 2486281 attaaataga ccatccccag aatccgcgat atatatgtac cgagcgttaa tacaaacgtg 2486341 cctcttaaca gtttgcttga catgtttctt catcaccatt ttctacgaag attcaacttt 2486401 tctattttac cacaactggg catttagacg gtaataaata caaaagcaat cctgtgaaca 2486461 ttcatgtccg cggcaaaaga cgtttaagga gcggctttct ttcgctataa tagtactgcg 2486521 gacgggtgtc cgcacacgaa atgaaaagaa agttgatgat aaagatgaaa caatatgacg 2486581 taatcgtaat cggcggaggc ccttcaggct tgatggctgc gattgcagca ggagaacagg 2486641 gcgctggcgt gttgctgata gataaaggaa ataaattagg acggaaactc gcgatttccg 2486701 ggggcggccg ctgcaatgtg acgaaccgcc ttcctgtgga agaaattatc aagcacatcc 2486761 ccggcaacgg gcgtttttta tacagcgcgt tttctgaatt taataatgag gacattatca 2486821 agttttttga aaacctcggc attcaattga aggaagagga tcacggccgg atgtttcctg 2486881 tgaccgacaa agcccaaagt gtcgttgacg cgctgttaaa caggctaaag cagctccgcg 2486941 taacaatcag aacgaacgag aaaattaaat ctgttttata tgaagatgga caggcagcag 2487001 ggattgtgac gaataatggc gaaatgatcc atagccaggc agtcattatt gctgtcggcg 2487061 gtaaaagcgt gcctcatacc ggaagcacgg gagacggcta tgaatgggct gaagccgcgg 2487121 gccataccat aacagagctg tttccgacag aggttcccgt cacttctggc gaaccgttca 2487181 ttaagcaaaa aacacttcag ggcttatcac taagagatgt agccgtcagt gtgttaaata 2487241 aaaaaggcaa accgattatc acacataaaa tggacatgct gtttacccat ttcggcctct 2487301 caggacctgc cattctcaga tgcagccaat ttgtcgtaaa agagctgaaa aaacagcctc 2487361 aagtgccgat cagaatcgac ttgtatccgg atatcaatga agaaacgctt ttccaaaaga 2487421 tgtataaaga actgaaggaa gcaccgaaaa aaaccattaa aaacgtgctg aagccttgga 2487481 tgcaggagcg ctatctccta ttcctgctcg aaaaaaacgg catctctccg aacgtatcgt 2487541 tttctgagct gccgaaggat cctttcagac aatttgtaag ggactgcaag cagtttactg 2487601 tcctcgcaaa tggcacactg tcgcttgata aggcatttgt cacgggaggc ggggtatctg 2487661 taaaagaaat tgacccgaaa aagatggctt ctaaaaaaat ggaggggctt tatttttgcg 2487721 gtgaaattct ggatatccac ggctacacag gcggatacaa tattacctcc gcccttgtca 2487781 caggcaggct tgcagggcta aatgccgggc aatacgcccg ttcttaatca ttactcttta 2487841 aatctcttgc cgccaaactc acatttgaac attccccgca ttcatgttag ggtgagactt 2487901 gttttgtttc acctgattgc ggggtaattt taagagagga atgagctgcc atcgtacgac 2487961 catactaagc ctgcgagcaa gatataggcg tacacaaaaa attagagggt gagaaatgtt 2488021 gaaacatata tctagtgtat tttggattgt gattgcaatc acagctgcag ctgtattatg 2488081 gggtgttatt tctcctgaca gcctgcaaaa tgtgtctcaa tcggcacaag catttattac 2488141 cgattcattt ggttggtatt atcttttagt tgtctctttg tttgtcgggt tttgtctctt 2488201 tttgattttc agcccgatcg gaaaaatcaa actcggaaag cctgatgaaa aaccggaatt 2488261 cgggttatta tcatggtttg ccatgctgtt cagcgcaggc atgggaatcg gcttagtatt 2488321 ctacggtgcg gctgaaccga tcagccatta cgcaattagc tctccatcag gtgaaacaga 2488381 aaccccccaa gccttcagag atgcactccg ctatacgttt ttccactggg gtttgcacgc 2488441 ttgggccatt tatgccattg tggcattatg cattgcctat ttccaattcc gcaaaggcgc 2488501 acccgggtta atcagcagca cactgtcacc gattctcggg gataaagtaa acggaccgat 2488561 cggaaaggcc attgactgta ttgcagtttt cgccactgtt gtcggggtgt caacaagtct 2488621 tggtcttggc gcaacccaaa ttaacggcgg tttgaattac ctgttcggca ttccgaatgc 2488681 gtttatcgtc caattggttt taatcattat tgtgacagtg ctctttttac tttctgcgtg 2488741 gagcggactc ggaaaaggaa ttaagtattt aagcaacaca aacatggtat tggccggatt 2488801 gttaatgttg tttatgctcg ttgtcgggcc tacagtgctg ataatgaact catttacaga 2488861 ttctatcgga caatacattc aaaatatcgt tcaaatgagc ttcagactga caccgaacga 2488921 tcctgaaaaa cgcgaatgga ttaacagctg gacgattttc tattgggcat ggtggatttc 2488981 ctggtctcca tttgtcggca ttttcatcgc ccgtgtatcc agaggccgga cgatccgcga 2489041 atttttaatc ggcgtcttgg tgacaccttg tattttgaca tttctatggt tctccatttt 2489101 cggcgtatca gccatggatc tccagcaaaa aggcgcgttc aatgtagcaa agctgtccac 2489161 tgaaacgatg ctgttcggaa cacttgatca ctatccgctg acaatggtga catcgatcct 2489221 tgcattgatt ctgatcgcag tattctttat cacgtcagct gattcagcta cattcgtgct 2489281 gggcatgcag acgtcgtacg gttctttaaa tccggcgaat tctgtgaaac tcagctgggg 2489341 tatcattcag tccgccatgg cggctgtgct cctatattcc ggagggcttg ccgctttgca 2489401 gaacacagcg attctggcag cgctgccgtt ttctatcgtt atcctgctga tgattgcctc 2489461 tctctatcaa tcgctctcaa aagaaagaag agagatcaaa aaagcggaga aactcgataa 2489521 accaagaagt ccaagagtga aaaaagcata ttaacaaaaa agatctttcc gcgcctgcgg 2489581 aaagatcttt ttatttgcga tataaaataa gggcggaaaa acagtaaagc tgctcgccgt 2489641 ctgggtcgca cgccgccgaa accgtatatt tgatatctat cagctgctcc tccgatatcc 2489701 cttttaaaaa tgaattgatt tccgtttgta agtctttttc atgctcttca tcaaataccg 2489761 ctaccttcag cattttatcc gctctccttt ctctatcaat ctattccgtt tggaacagcg 2489821 ttatgataga gaaatgatga ttatctcgtt tccggataaa aagctttccg tatatgggat 2489881 ttcctctgtg gctcgccgcc gtgctgctcc actttcagca gcacggcata aacaatgcgc 2489941 atatggcagt agctgataag gctgacgctg aaaaaaggga caatgcccgg caggtacgca 2490001 agcaagaaaa agagagcaac agtcagcgca agcatagtaa gcgtatattg caaatacgcc 2490061 acactgagca agagcgaaaa tttcacatac agacgttttt tccagtcaaa atggacaagc 2490121 agcggaaaca cataaaaaag catggatacg aacaaaaagc caaatatcat aatggcgaag 2490181 cgcaggatgt gcagaaggaa atgacttgga taaattaagg ccaaatcaat ataaatgatc 2490241 actccgatga gcgccagtac agcgccgagc agatttgaac gaaaaaattc acccttgtat 2490301 tcctgccaaa acgttttgag caccggaacg ttgtcctgcc cctggatcca cttccgcatg 2490361 acagcgaata aagccgcggt cgcgggcatg atgccaaaca cgccgagacc gagcaacgta 2490421 aaaaacagcc acagcaagtt tgtatacgca aatctcataa tccattcgca aaaacgcagc 2490481 atccgtccca gtgagccatc atgttccatg gcgccccctc cttttttgca ttatacattc 2490541 tgcatctgaa aaagctcttt catgccgatc ggcttctttt cggcaaccga gcgccacatt 2490601 ccctcaccaa ccgcgatgga gtaggctcca gcttcagccc cggctaaaat atcatagcgg 2490661 cgcagcgggt ctttccctaa aaaaagatcc tcaagcaaaa gcggatcacc tccgccatgc 2490721 cccccttcat ttttgaccac ttgtatcgtc tgctttgatt caaaaagcgg atagtattcg 2490781 attgtctgct caggaaaagc aaacggaatt ctggaaggtt cgtgaaattc atttgattca 2490841 atacgtcctt ttgtgccgtt gatcgtcagc cggtagcctt catacggggc cgaaaaaata 2490901 atcgagtagc ttaacagtgc gccgccatca tatttgactg ccgccacgta cgtatcctcg 2490961 atgtcaattt cctcgtcaaa aatacacgcg tcaggcctgt atgcagtata taagctggac 2491021 tggtctcctg cttcaagatg atcatccttt atagaagctt tagaggaacg gggatgccac 2491081 cttgaatagt agtggcattt ttctttaaca cggcacgtcc cgcaaaaacg cccgtcttct 2491141 tccggcaagg ggttccactc actgtccggc ccatagtaat tcaaggcgcc ataagcaaat 2491201 acctcttccg gattttgccc gagccaccaa ttgacgagat cgaagtgatg tgttgattta 2491261 tggacagaaa gaccgccgga aaactgtctc gacctgttcc agcgtttaaa atagctggcg 2491321 ccatgatacg tatcaatata ccaatttaaa tcaacagaag tgaccctgcc tatttttccg 2491381 tccagaatca tttcttttat tttccgatga aacgggctgt agcgatagtt aaacgcgacg 2491441 gtgacttttc cttcgctttt ggcctccgct tcaagcaccc gattcgcatc ctgcactgtt 2491501 gtcaccattg gtttttcagt aatcacatct gtattccact gaaggctttt tacaatatat 2491561 gcgacatgcg tatcgtccct gcctgccaca atgacgatat caggctttga gacgcgcatc 2491621 atctcgtcaa aagcatcttc gctaaactca ggcacgtggg ccagctcggg aaatttcttc 2491681 ttgcaaacgg caaaacgttt cggatcggca tccagcaatc ccgtaatctc ataatgagtt 2491741 gaaaaccgct ccatcagtgg tttgataaac atactgaatg ctctgctgct caatccgcaa 2491801 aagacgatgt tcttcaatat cctcacctct atcgggcttc agttagttga gaaatcagct 2491861 gcagcgcttc ctctgttttt tcagcataca cagggataaa cgccgccata tcgcgattca 2491921 attgaaaaga atagccgttc agctgttttt tccctttttc gatctgaacg gcatagatcg 2491981 ttttttctcc tgttttttta ttaacagttg tataaggaga tgttttttca ggaggcaatc 2492041 cgtttaacgg ctgaaaattt tccggatcat cgtaagcttg aaacatgtct tcaggcacga 2492101 tgaaaacatc tccctcatgg gcggtaattt cagtcagcag tttttcctga aaagctggaa 2492161 agatatcgac cttcccggca ttctgctcgg cggccttttt tattttttcc tgtacgccag 2492221 cctgcatatc agaaaagaga atgacatgca ttccgtccgg cctgcttgag catgatgcca 2492281 aaaagagcac tgagacgatc acacacaaag ccgtacgtat cctttttgtc atttccccgc 2492341 tgacctaaaa agaggctcca gctctgtcat agctaaaata aacgcgccgg ctccgtgcag 2492401 atcgtttgtg cttctttcgc ggctgacata atagtcatag aaaccggctg acgttccgac 2492461 acatatgtct ttgacgagaa acgctccgtc ttctgatgtt tcggttttat gctgaatcaa 2492521 gccttgatac gcttttagca gtgttgtttc gtaagctctg tctagatagc ctttattgat 2492581 tccttttgcg attgcgtaca tgtacagaca ggatcctgag ctttccagcc agttatcaga 2492641 cctgtctccc ttatcaacga tctggtacca taaccccgtc tctttgtctt gatagcgaca 2492701 gatgctttta atcatgtcct gcagcgtgtt tttccacaca tgacggttcg gatgcttctt 2492761 cggcagctct tcaatcatgt cagcaagaga catgacgtac cagccgatgg aacgtgccca 2492821 aaattccggt gaacagcctg tctcttcatt ggcccaaggc atttttttcg cttcatccca 2492881 ggcgtgataa aaaagtccgg tttttgcatc cttcgtatgc tttctcatca atgactcctg 2492941 aagcacaacc tgatcaaaca gctccgtctc ctgcttcaga ttggcatatt tcagtgcaaa 2493001 cggccccccc atgtataagc cgtcaagcca catttggtaa ggataaccgt ctttgtgcca 2493061 aaaaccgccc tcagacgtcc ggttcagtgt tccatataag ctgcgcagcc tttttgccgc 2493121 tttgacatac cgttcatcct tcgtctgctc gtataatgga aaaagaatga gacctgcttg 2493181 aatggcgtcc agttcatctc ttctaaataa tagattgcca ttatcatcga ttaagagatc 2493241 tgcataagcc ttcgcatact caaaataccg cttttccccg gttgcttccc acagccgcaa 2493301 tacaccgcat aagaaaacac cctgatggta gtgccagcgg tttgcaggtg gcagctcctc 2493361 gactgtgtac gtgttcataa tggtgtttgc caatgcctcc gcgtacgtaa gaggcgattt 2493421 tacagcgatt gattgatcca ttgatcccat ccctttccta ataaattcct tcctcgccaa 2493481 atttcttcgc caaacgattc gctagcatga ccaaaatcag cccgaccgcc gctttaaata 2493541 cgccgactgc tgtactgtag ctgaattggc cctgtttcag ccctgcagta taaacatacg 2493601 tatcaaaaat ttccgccact tccctgttag tcgcatttaa cagcaaatac acatgctcga 2493661 agccaagctc cagcgtgtct ccgattttca aaatcagcaa aacgacgata acgcttttaa 2493721 tggcgggcag cgtaatatgc cacatttgcc gcagccgtcc cgctccgtcc attttcgccg 2493781 cttcatacag ctgggggtca accgctgtaa tggccgccag ataaatgatc gtcgaccagc 2493841 ccgcttccct ccagataacc tgcagaatat acaggggccg gaaccattct tcgttcagca 2493901 gaaaattgat tttttcaccg ccaaaaaaca caatcagttc attaatcaag cctccgtcta 2493961 ccgttaaaag cacaaacgaa agcgatacaa caatgaccca agacataaaa tgcgggatat 2494021 aaatcagcgt ctgaacaaat tttttaaaga gagcaatccg cacttcgttc aatagaagcg 2494081 ccagcagtat cggcaccggg aaaaatatgg ccaggttcaa agcaaataac acgagcgtgt 2494141 tttttaacaa gagaaaaaat gtaggctcag taaacagcct gataaaatgc ttcagcccca 2494201 cccactcact gcccaaaatg ccgaggaacg gctgataatc ctgaaacgca atcacaattc 2494261 cccacatcgg gacatactta aaaagcaaaa aataaataca ccccggcaaa atcatcaagt 2494321 acaaatattt ttgttgaatc agcttgatta gtaagcgctt tcttttttct tttttaaaaa 2494381 tgactgcatc aacagccggc gcttgcgctt ctgctgtttt cattttttcc tagcctcctt 2494441 tcacggattc ttgcattcac tgtagcgcag caggcaaaag tccgtctaca atcatatgat 2494501 cacatcctgt tttatccctt tataatcaag ggttcagccg gtccacctga aaaaaagaca 2494561 ccgatattag aaaatgatta ttgacaatat ctatcaatct ttggattaat tgtattaagg 2494621 tgaagtggat gttatgaaat ggggggtttt atgaaaagaa gccaatacaa gttttactac 2494681 aaactgatca cgtttttctg cctgctcagc accattccgg ttattttggt cggattattt 2494741 tcgtacgagc actctcagaa aacggctatt tccaacgttt cggaggaaaa attcgacaca 2494801 ctccagcaga cccagcaaag catcgagcat atattgaaaa ccgtcgatca ctctttaacc 2494861 cactatgtga gttcgccgcc tctccttcgc acattgtccg agcctttgca ctcagaccaa 2494921 tttcaaatct ataaccaagt gaaccaagag ctcaattatc tgcaaagctt tgataccgat 2494981 ctgtccaaca tgacgttagt cagttatacg aaaaaatggt acatgaacaa ttccggtttg 2495041 taccgtttga atacagacac tcttcatgaa gcagcctcag cgtacacgaa acaaaaagcg 2495101 agccgctcct attggacgct tgaggaaaac aatcatttga tttcaaccaa agaaggcaca 2495161 gcagaaaact gccgctacaa tatcaattta attaagcagc ttcctttgaa cagcacaaat 2495221 acaaagggat tggccgccgc aagcatcccg agctgttcgc ttgtcaaaaa tatgcccggc 2495281 tattcaaacg ccaacaacct gtttatcatc gatgaaaaag gcctcatcat ccttcataac 2495341 aatatgtctg acgttggtga atctcttcat aacgacggct ttgtccaaaa agtgctggcg 2495401 caaacggcca atagcggaca gtttgaaaca gtgattgacc ggattcatta taaagtcacc 2495461 tatcaaaaat ctgactataa tgcatggact tatttttctc tcgtttccct gcctgagtta 2495521 aaaaaagaag ccaaatcaat cggctggatc acttttgcag tatgcctcat tttgttaacg 2495581 ctttcattgc tgttctcttg gcttggctcc cgccattttt acaagccgat cagggtgctt 2495641 tacgaatcat tcgcaagaca tggagccata caagagaaac aacagcctcc tcaaaatgaa 2495701 tttgagttaa ttgaacagag ctttaagcag ctgaaggaca gaaatgacga ccttgaagaa 2495761 acgatgaagc agcaggccac tcatctgcag caatatttta tggtcaggct tatgcttgga 2495821 aaactgacgg atgaggaggt tgataaccgt tttgaaagcc tcggcttaaa gcaaaattgg 2495881 cggcaccttg ccctgcttgt gctccaaatt gacacactga atcatacgcc ttatgagaaa 2495941 aaagatatgg atctgctttt gtttgccgtc aacagcctga ttgagcgcaa catcccgacg 2496001 gacaaacatc ttgcccccgc cgtagttgac aaacagcagg cgacgatttt gatcaatcaa 2496061 agcgggacaa aggaagaatt catggctgag ctgaatgaga ctgcaaggat gattcaggaa 2496121 aaagcggaag ctgagctgca gctgtctgtc agcatcggca tcagccagcc gtttgatgtg 2496181 ctgacaaaag cgaaaacagc ctatgcggaa ggctcagaag cgttgaaata tcggctgaaa 2496241 gcggaaaaca agtcgatcat cttttacgaa gaccttgacc agaaaaaaac cttcaaaacc 2496301 cattttccaa agcagcttca gcatgagctg ttcgatgctg tcaaagcagg agacaaggag 2496361 aaagcggata aatgcctgca cgcgatttta caagccattt tcacccagaa caccaacccg 2496421 tatcaatttc aaatcgccat cgcccgtttt ttgaaccatg tgattgagct gatgcatgtg 2496481 cttgggatcg aattgtttga gcttgaagaa aacaaaatgc tgtatgacca aatttttgag 2496541 ctgaaaacgt tcgaggatac cgaaaactgg ctaaagaatg agtttattga tccgatgaca 2496601 gacaaagtga acgcccgcgc ggatgcccag tacaaaaata tttccgacaa catcattcat 2496661 atcatccatc atgagtttga atccgaattg acactggacg aaatcgcacg caggctgcat 2496721 tacaacccaa attatttaag cagtattttc aaaaaagaaa tgggaatttc attcagcgag 2496781 tatgtctcaa gctaccgaca ccatatggcg aaaagctggc ttgccgaaac cgacatggcg 2496841 gtcaaggaca ttgccgaaaa gctgaaatat aaaaactccc aaaacttcat cagatcattt 2496901 aagaagctgg aagggattac accgggaaac taccgccagc aaaaaagaag catgtaaaaa 2496961 acccaaaacc gcttgcgcgt tttgggtttt tccaatgtta ttttgcttgt ttaaacgctt 2497021 cttcgtattc ctgaataatt tgttttcctc cgcttgactc ccatttttcc acttctttat 2497081 cgaactggct ttctgtgatg tctccaatca tatatttgta ggtcgcgtca tcaatgattt 2497141 tcttcagttc gtcaccccgt tccgactccg atgcggaata caggctttca gccgggtttg 2497201 agacgataat cttttcattg tcctcggtca gctcctcgta cgccgtccga agcggatctc 2497261 cagtgttttt taagtaggct ttatcaatgg caattaaagc ggacagcggc tgaatatcag 2497321 tctgccagtc ttttacctgg ctttctttgc gtgtaaacgt tttgtcctca cctttgttgt 2497381 aatgaacgcc gtcaatgcca taagtcatca ggctatagac atcttcttcg gcaattcggt 2497441 caaaaaacgc caagatccgt ttaagctcag cttccgtttt cacactcgtt ttcgggaaag 2497501 caaacacgcc gttatggcct cctgatgccc atacccgctc tttcccatct gggcctttta 2497561 tgcggttgat gatctcgagc ttcatcgatt tatcagaggc atggtcgcgc agattgaccg 2497621 catctaccat attgccaata taaattccgg cttttccttg agaaaacagc tcttgctgct 2497681 gggttttgct tgtgacggga aaatccttat tcatataccc gttatcacgc agctttttca 2497741 tatagttcat cgtgtctttg tattcctgtg tcatgaaatc aggcgtgaat ttgccgcccg 2497801 attccttcca atctgtcggc atgccttcat acgagccaat cgttttaaac gcgccgtaaa 2497861 tcaagtcatt acggtctgcc agcccgaatg tatcatcttt cccatccttg tccgggtcgt 2497921 cctccgtaaa tgctttggcc acttcataaa gctcatccaa cgttttcggg gttttcaaat 2497981 ttaaattgtc cagccagtcc ttccgaatga cgatcccctg tctggaaagc gggcgctctc 2498041 tgtatatccc gtagagcttg ccgtcaattg tcacattttt attaatgagt ttgttcattt 2498101 tgtttaagtt gggataatcc ttgatataat cgccgatttc ccaaaacatt cctgaccgaa 2498161 aggcattcat gactgacgaa tttttaatat cctggatggt cacgatttgc ggaagattgc 2498221 cggctgcaag cgctgcattc agcctgtctt ctttcaccgc gtctggaacc caggtgatgt 2498281 cgagttctgt atttgtcagc ttttcaattt ctttaatcgc cctgtctttc ggcggctgct 2498341 ggtgatacaa aatcgccatc caagacagct ttacctttga atctgggcca gctttgcctt 2498401 cagccgaaga ctgatcagtt cctttacagc ccgccagcac tccgccgagt gccagtacaa 2498461 gcacaatcaa aagcaccctc catttgtttc ccatcgtacc cctccgtttc atatttcttt 2498521 atcctttgac agatcccagc aaagctcctt ttgcaaaatg cttttgtata aacggataga 2498581 caagcagaac agggatggtc gccaccacta tgaccgccat tttaatggtt tgctcaggcg 2498641 gcgggctgcc cgaccccatt tcagacatat ccccctgcat accgcttgat acaatgacga 2498701 tttggcgcag aagcacctga attggccatt ttgctgaatc atttaagtac aagatcgctg 2498761 tcatatacgt gttccaatac gtgaccgcat aaaatagtga aatcgttgcg atcgcaggaa 2498821 gagacagcgg cagcacaatt ttaaagaata tgcccagatc attgcacccg tcaattttcg 2498881 cggactcttc caggcttgac gggatatttt gaaagaagtt tttcagaatg atcaggttaa 2498941 aggcattaat ggctgtcggc aaaataagcg cccagtaaga atcgagcaat ccaagcgatt 2499001 tgaccacaag gaaagtcgga atcatgccgc cgctaaacag catcgtaaat acgacgagaa 2499061 acatgagcgg ctgccggccg attaaatcac ggcgggataa cccgtaagcc atcagtgacg 2499121 aaagaaacat gctgaccgca gtgcctatca ctgtcacaaa cacagaaaca agcaaactct 2499181 tataaataat atctgttgaa aaaatgtagc gataagcatc tagcgaaaaa gtggtcggta 2499241 ttaaaataaa ttttttcgac acgacttctt ctactgtggc aaaggatgct gcgataacat 2499301 gaatgaacgg aagtacgcat attaaagcga acatcagcaa gaaaccataa atcaacatat 2499361 caaacagacg gtttttcagt gaatgtgcga tagctcccac ctccctttgt aagcgttatc 2499421 atatttttgg aaaccgagct cagcatgtga cgatatcgtg tctaaaatgt agcaaatctg 2499481 tgattgccat gtctataatc atttgaacag tgtccccggc cgggcggggg ctgccgcgaa 2499541 ttgagaccga taacaaaaga aaaagagcat aatcttagaa aatgattatg ctccgttctc 2499601 ctcctcgttc agaagttcag ccgtattgat ttgtggcgaa aacccaagtt cattcacggc 2499661 agattcaatg gaccatggcc ggcccggatt atcagagacg gcgtaataag tgccataccg 2499721 gatgttggtc tcaatggcgg ctttgaaaat cgacagcaga tcggggtgag aaagcagtgt 2499781 ctttttcgtc cgttcttttt catgcagcgt atccatttca tctgtcacga ctgttccgat 2499841 tcgaaggttg attactgata gcttattttc caaataaaac aaatggccga tctgttcaga 2499901 ggtcagcttt aatacaccgt acaagttttt tgacagcgga taatcgcttg ttgtgatttc 2499961 ccgtcctaag agcgagcgcc cgtctttttc atatacatct gtgacatgat tgctgctggc 2500021 gaacacgagc ttttgaatgc cgagctccgc tgccgcacgg cacagataat agcttgccct 2500081 atagaaaaca tccgtcattt tttcaaactc agcgatgtcc ataatatcgt atttgatttt 2500141 cacagcgagt aaattcaaga tggcatcggt atcttttgga atcttcttca acagctcctc 2500201 ataatttgcc gcgtcagcct gaatggaaga ggctttgcca tcgaaatgat ctttatcaag 2500261 cacagtcact tcatagtctg aaataagccc ttcagcaagc agtctcccaa tcacaccatt 2500321 tccgccggcg atcagcactt ttttcacgat gttcactccc cttttttata gattgcccat 2500381 tttcggcggg gctgacactt ttttggcact cacattctta ggcttattca aaagtcaccg 2500441 gcagctcctc aagcgcccga aatccaaaaa gcggccgata ccgccattca aaatccgcaa 2500501 gattaaggct gggcattcgc tgcagaagag tgttaatcgc aatttgcgct tctaatcgtg 2500561 ccagcgagga ccctaagcaa acatgatggc catgcccgaa tgaaagatgc ggattaggac 2500621 ttctcgtaat atcgaagaca tcggggttcg tgaatatgct agggtctcga ttagccgctc 2500681 ctaacaaaag atagacttgt tctccttgac ggatcgtcac cccgcagatg tcaatatcct 2500741 ctgacgcaac tctggctgtc atttgcgtgg ggctttcata gcgtaaacat tcctcgactg 2500801 cggtaccaat aagatctgga ttttctctca gtttcaaaag ctgttctgga tgctgcagca 2500861 gacaaaggac tgaattgctg atgagattga ccgttgtctc atgtccggcg atcgccagca 2500921 atatgcacgt agatgccgcc tcctcttccg tcagcttatc cttttctctc cccttcaaga 2500981 gcatgctgat catatcctgt tgagggtggc gttttctctt ttgaatcagc tctttgaaat 2501041 atgccatagc ctgcacagcc ataatattgc cctctgttaa tgcctttctt gagcgggtaa 2501101 aatcaatcgt ttgaatgaga ctcgcagccc actcctttaa ttgctcccta tcttcctccg 2501161 gtacacctat aatgttagct atgacaaaac ttgctaaagg aaaagcaaag tccgaaatga 2501221 cctccatctt ttttttacct tgcacttgat caagcaaatg atggacagtt tcaatgatat 2501281 acggctgata actctctgtc gttctcggcg taaacgctcc gctggcaagc gtccgcaatc 2501341 gtctatgatc aggctggttc tgaaacagca tcatttgatt ttgcacatgt gaaaggtcct 2501401 gatatttggt tgagctctca ggcagcgggg tgcggacttt gaatctcgca tctttcaaaa 2501461 tagcagccgt ttcttcatat cctgtgacat accagcccgg gtattttaag aaactccctt 2501521 tatagatagg atgaacagct cgcaatgtgt cgtaaaaaga atatgggttt ttcaaaaact 2501581 cagaagatgc agttgacgat gcaattgtca cgtgattttc tcctttctgt tcaaaaataa 2501641 aaacaatcga catcataccg attgctttta ttgattcttt cagcttttcg cacttaaact 2501701 agccttcatt tcttcgactg attcaacttc aaagcctaaa tcactcagca ttttatgatc 2501761 ctccgtctcc tcttgcccgg cagttgttaa gtagtctccg acaaaaatgg agtttgcggc 2501821 gtaaagccct aatggctgca atgtgcggag attgacctct cttcctccgg aaatgcgaat 2501881 ttcttttgat ggattgataa aacggaacag cgccagcact tttaaacaat acagcgggtt 2501941 taattcgttg acgccttcta acggcgtgcc atcaattgca tgcaaaaaat tcacaggaat 2502001 ggaatccgcg tcaagagcct tcaagctttt ggcgatgtca atgacatcct gtttcgtctc 2502061 cttcatcccg ataatggcgc ctgaacacgg agacagcccc gattcttttg cgatttcaac 2502121 cgtattgact ctgtcatcgt atgtatgtga ggttgtgatg tttgaatggt ttctctgtga 2502181 cgtattcaaa ttatgattat agcggtctac tcctgcatct ttgagccgct tcgcctgctc 2502241 tggcttcaac agtccaagac atgcacaaat cttcagtcca tacgtctctt taatttcctg 2502301 aaccgcatct acgacctgat ccacttctct gttagacgga cctctgccgc ttgccacgat 2502361 acaatatgtg ccgatattca gatcgtgcgc ccgcttcgcg ccttcaagca gcgtttcctt 2502421 attcaccatc cggtaagact caatcggcgc tttcgaaatc gcagactgtg aacaatagcc 2502481 gcagttttcc gggcagagcc cggatttcgc attcataatc atattgagct ttactttttt 2502541 tccgtaaaag tgttttctga tgtgaaaagc cccgtgcatt aatagcaaaa tatcttcatc 2502601 aggacaatgt aatattgaaa gcgcctcttc gtcagtcact tctgctccag ccagcacccg 2502661 gtctgcgagt tccatccatt gattcattct cataccccca cttgattcat cagtaatgat 2502721 agattgatat ggtcttttac catatgtaga accgtttctt tcgtcacgtt ggcaagcttt 2502781 ggcgtaaccc ctaaaatcgg cacaccgcat aagcgctcaa tcatctcagg attggttttt 2502841 tcatcttcat caggagagtc actgattcca ttgatgataa ttccggcgat tggaagcccc 2502901 atgctttctg catatttgac agttaaaaag gtatgattaa tggttccaag gcgaggacgc 2502961 gccacaataa tcatgggaag ctgcaacgct tttatgacat gactgaccaa atagtcctct 2503021 cccaatggca cagaaatacc gcctgcacct tctacgatga agcattcatg tttttctcta 2503081 atccgccccc aatggcttaa aacctcttcc atggtgacag tctttccctc aagtttccct 2503141 gcaacgtatg gtgcaagcgg cgccttgaag gcaaaaggcg taatgtcttc atgagaaaga 2503201 ctggtctgcg acatatcttt cagcaaactt gtatcactat ctggatgatg gcgcgatatc 2503261 ccgcttaaaa atggtttata caccccgaca tgtctattat tgtctttcaa taaggcagca 2503321 agaccgctgg atataaccgt tttccctact tctgtatcag ttcccgtcac aaaaaaaccc 2503381 ctcaaatgat gtgcagctcc tttccgattg aatgaaatgt ttgcagcaaa tgatcaatat 2503441 cacccatact gtggtcagac gtgattgtaa ttcgaatccg gctttcaccc ggcgcaacgg 2503501 ttggcggccg aatggcagga gcataaattc ccttgccctg cagtttttca gcaaatagga 2503561 ccgttttatg ggcatcgcca atgactacag gaataatcgg tgtgtgatct cctttcacca 2503621 cataacccat attcttcaga ctggttctga tcatgctgat ataagaaaat aaaagctgtc 2503681 gtttttccct gctggcttca atgatgttga aagcctcgtg agcagccgca cagctggctg 2503741 gcggaatagc ggtttgaaag ataaatgttc tggcatggtt cagcaaaaag tcgatgaaga 2503801 ccgctgatcc tgccgcaaaa cctccttccg cgccaacagc tttgcttaag gtgccgataa 2503861 caatgtcggg acaaacacca aagtattcac tcgttccttg tcccgaatcg cccaaaactc 2503921 ctgttgcgtg ggcatcatca acgaccacga aggcatgata gcgtttcgca agtgagatga 2503981 tctgatcaag aggggcgatt gtgccatcca tgctgaatac tccgtctgtt acgataaaac 2504041 ggcgctgata acgctgtgtt tcattcagct tgttttcaag atcattcata tcaatatgcc 2504101 gataaacaac tgtatcagcc ttagaaagtc ggcagccgtc gatcatactt gcatgattga 2504161 gctggtcact taaaatgaca tcttcctttt ctggcaagga tgaaaggaca ccgacattgg 2504221 ccaagtaacc gctcgaaaac agcagggccg cttctgtcag tttaaagctg gcaatcttct 2504281 tttctagctt ttcatgccag accgaattgc ctgtcgttaa acgtgaaccg ctgcttcctg 2504341 tcccaaattg ctgcaatgct gtttgggctg catcgatcaa acgtctatcg cttgcgagcc 2504401 ctaaataatt gtttgaggac cagaccgttt gattttcgcc atcaatattc ctctctggaa 2504461 ccggcgctcc atccattgac cgcaggttac gatgtacgcc ggcttctttc attctgtcta 2504521 accgctcgtt taaccaggaa tcaatcttca aggctcgtaa cctcgtggat cgcttgtttc 2504581 ataatggcaa ccatttccga gagctcttca gctgtgctgg caagaggagg aagaaatgca 2504641 atcacgtccc caagcggtct tgtcagcatt cctaactctc tcatttttaa ggaaactttg 2504701 tatccaatcc gccgatcagc cgggtaaggt tctttagttt cctttgatcg tacaagctct 2504761 gcaccgcaca taaagccaag ctgccgaata tccccaacat gaggaagagc gtgcagatct 2504821 tgaagaagaa aatggagctt tttacttttt tccgctactt gttccacaat gttttcagat 2504881 tcaaataatg ccagattttc aagcgcaacc gcacagccaa gctgattgcc tgtataggaa 2504941 tggccatgga aaaaggtttt taggttttca taatcatcat agaatgcctt atagatgtct 2505001 tcagtggcaa acgtaacggc aattggcaaa tagcctcctg taatgccttt accggcagcc 2505061 atcagatcag gctggacatt ctcgtgctcg cacgcaaaca tttttcctgt acggccaaag 2505121 cctgtagcga cttcatcaac gatcattaag acatcgtatg ttgtacatag ctcgcgcacg 2505181 cctgccaaat atccttccgg catcacgatc ataccggacg cgccttgtac cattgattca 2505241 atggaaagcg cggcaatttc ctcatgatgt tcctcaagca gctgtgcaag ctctcggagg 2505301 cactgatcac ggcactcatc aggatcaccg ctttcagaac gatacacata aggaatcggg 2505361 gccttgtaac tctcgaacat caacgggccg tatacgtggt gaaaaagctc aattgaaccg 2505421 acactgacgg cgccaatcgt atcaccgtga tacccgtttt tcattgcgat gaatttttgt 2505481 ttctcgggct tcccgatgtt cttccaatac tgaaacgcca tttttagggc tatttccatc 2505541 gcctctgcgc cgctgtctga ataaaagacc cgcgtgagct tttttgggct gatgtcgatt 2505601 aatgtttcgg caagctgggt tgctggaaca ttggtcatgc ccaataacgt ggagtgcgca 2505661 atttttccga gctgtttttt tatggcgtca tctagttctt ttttgcggtg tccgtggaca 2505721 ttaagccaaa ccgatgaaaa accgtcatag tattccttgc cgtttatgtc tttgactttg 2505781 attccagtcc cgctttcgat gattaagggg ttttcatcat aatctttcat ttgggtaaat 2505841 ggcagccaga ggtgcttttt acttttttct atcaaatcat gagtcatgat cttcctccca 2505901 ctctattaaa ataggctgct tctccaggtc atgtatgtac gtgtttacat cattggatcc 2505961 atcaataaaa aagactcggc agccctcttc agtcccgtat tctttcattg ctgtaatacg 2506021 ctgatagccc attttcttac ccgcaacata gcctgttatg taatccggat cgtccgacca 2506081 gcataattct gcaacgactg ccgggtgccg gcttaccttt gaagcgagcg caagggcctc 2506141 ttttattctt gaatgagctg gcacgtgact gtgaagcgcc catttttcaa aattagcgtc 2506201 cggccaatcc attctggaga cccgcacccc tttttctttt gtttgatcca ttcgcttgcc 2506261 tgtatgaata tcaaacaaca ccgcacccct gacatctgac cattcaggga tttgttcata 2506321 tgctttttca atcacgtctc gtgaaacgcc ttctttttcc aataacaatc gggcaagctt 2506381 ttgtccttct tccgggcagc tcacttcatt cgtatgcaca ggcaatggct gaatggtttt 2506441 tatcgattca tgtacctctt caaattgaat ttgcataaaa tcaggttttc ctcttgaatg 2506501 ggataaccct ttttctaata aagcattgac tgtatgcttc atctcatgga aaggaataag 2506561 ccgttctccg ccggatatat gctttccgcc gtcttcatga gatccattca ttgaagccct 2506621 cattctgaca ctataaaaag tttcttcttg catcatttct cgccctttca ctgataactg 2506681 aagaacgtgt agcgcttctc acctaaattg ttaaccaatt atattcaaag gttaacaatt 2506741 agaatatatt attctctcct gtttctgtca atagaagaaa ggatcgattt atggcagttg 2506801 gttaaaagga aacaaaaaga ccgttttcac acaaaacggt ctttttcgat ttctttttac 2506861 agtcacagcc acttttgcaa aaaccggaca gcttcatgcc ttataactgc tgtttcgaaa 2506921 tgtcccgaag cagaacggac cactcggtag caatcagcag ctccctgtcc agcatagaca 2506981 gctgtcaatt ctttttcgat tttgtccacg ccctcagccg gcgttaaccg atcgtgtaca 2507041 ccaacaagac taaggtgcgg gcgcggcgcg atcaggcttt ggatctccga tgcggaaaaa 2507101 tgctttgcaa gcgatgggac gtaataataa aagccgtgcc tgtcaagatt ctgtgttttg 2507161 atcagcacgt gatgatccac ctggctgcac aaatccacac acaccttaat ccggtcatcg 2507221 agcgccgctg tccaccacgc catcaaacct cccatagaca tgccgatggt tccgatcctg 2507281 tcaggctgaa catcagagcg tgactgcata tagtctaacg cacttaaact gtcataaatc 2507341 atcatccccc acatcacttt tccggtgaga agcatttctt taaatatctc gctttccgct 2507401 tttccccgcc gatctccaaa cccccaatga tcaatcgcaa gaacgccgta tccgagtgaa 2507461 gtaagctcat cagaaaaaga aggcgttttc aaataatccg ctccctcaat cagctcactt 2507521 tttcccctat catactggcc tccatgcgaa tgctgaaaca atacggctgg gcacggtcct 2507581 tctgttttct tcggcttcac aaaataagcg ggcgcctttt catgtccatt taaatcgagc 2507641 aggagcgttt caacgatatt ttcttctctt tcttcaatac gtaatgtctc aacactgatt 2507701 ggcctccgat caggcaaatc accaagcaat cgaaacagtt gctttcttct ttcggctctc 2507761 atcccatcac ccttccttat tcgcttactt cacatttacg agacagatct gggttcccct 2507821 ttatttttcc aacataaatc acatcattta ctaaatattt agtaaatatt atggaatatt 2507881 tcgaaaacaa ttattgtaac cgcttacttt tatatgataa tatcaattta tcaaaaacag 2507941 atgagttaat attttactaa atagatgaga gggataccca tggttcgtat taaagatatc 2508001 gccttgaaag ctaaagtttc cagcgcaact gtgtccagaa ttttaaatga agatgagtcg 2508061 ctttctgttg cgggcgaaac gagacaaaga gtcatcaaca tcgctgaaga gcttggttat 2508121 caaaccgttg ccaaacgccg aaaatcccgc gggcaaaaac agcgggctca gccgctgatc 2508181 ggtgtgctga gctgtctgtc ccctgatcag gaaaggcagg acccttattt ttcttccatt 2508241 cggaaaggga ttgaaaagga atgctttgaa caggaaattt tcattacaaa ttcgattcat 2508301 ctcggctcct ttcaggaaca tatctttcgg gaattggatg gtgtcattgt catcggccgt 2508361 gttcatgatg aagcggttaa gcatatcagc gggaggctgg agcatgccgt atttatcaat 2508421 cattcaccag atccgcaagc atacgattcg attggcatcg attttgaatc ggcttcacgc 2508481 caggcgattg atcacctttt cgacttaggc tacaaacggt taggctacat tggcggacaa 2508541 gaaaaagagc atacgctgaa ggacggccaa agcattcgca gaacgattga agataaacgc 2508601 ctgaccgctt ttttggagtc agccgccccc cagcctgagc atgtgctgat cggagaatac 2508661 agcatgcgtg agggctatcg cctgatgaag aaagcaatcg atcaaggcca tctgccggaa 2508721 gcattcttta ttgccagcga ttctatggcg atcggcgcat taaaagcgct gcaggaagcc 2508781 ggactgcaag tgccgcggga taccgcaatc gtcagcttta acggcattga ggaagctgaa 2508841 tttgccagca cgcctttaac gacggtgaag gtatacacag aggaaatggg ccggacaggc 2508901 gtaaaactgc tgcttgaccg tctcaatggc cgaacgcttc ctcaacatgt caccctgcct 2508961 acaacattaa tcgtaagaca aagctgcgga tgtacagcaa aggaggtgac ataagcaaag 2509021 attcatcacg atgataagga ggaaaagatg aaacacactt ttgttttatt tctctctctt 2509081 attctgcttg ttctgcccgg gtgttcagca gagaaaagct cagcagatac cgcaaaaaag 2509141 acgttaacca tttattctac aatgtcaacc gacagtgaaa gagatacgtt cagaaaacta 2509201 gcggcagcat tcgaaaagga acacagtgac attcatgtca gccttcattt cccaggcaat 2509261 gactatgaaa atatgatgcg tgtcagaatg gcggccaatg atttgccaga tctattcgat 2509321 acacatggct gggggaaaat caggtacgga gaatatacag cggatctccg ggatatgaaa 2509381 tggactcaag atcttgatcc caatttaaac agcatcctca aaaataaaag cggaaaggtg 2509441 tatgcctatc caatcaatca ggcaaaagac ggtctggcgt ataatcgcaa tattttagac 2509501 cgttacggca ttgctccgcc ggaaaccatg gatgacttta tcaaagcact gagaacgatt 2509561 aaagaaaaga gcaagggaag cattgttccc ttctggtttg ccggatatga caaaagctca 2509621 ttcgcccaat attacgacca attcgctaca cctcttctca tcacagaccc tgcccataat 2509681 gaaaaaaaac agctcatcaa cggcactttt caatggagta aattcactta tttatcagaa 2509741 atcctcaaac aaatgcagaa agaaaaattg atcaatatcg acgccgtcac ggcaaaaaaa 2509801 tcacagctca ttgaattaat ggcccaaaac aaaatcgcct ttacaatgca aggcggcaca 2509861 ctcggccaag acgttgccca gatcaacccg aacgtcaagg tcggcattat cccgacacct 2509921 gccatccatc ccggtgatga cccgatatgg atcggcggtg aacgctacac ccttgcagca 2509981 tggaaagatt cgcctcaatt aaaagaggca aaagatttta tcgcatttat ggcccgcccg 2510041 gccaatgcca aacaaatggc tgaagccaca tcgcttcctt cagggctgac caatgtgaaa 2510101 gctgatattt tctacgcaaa cgattatgag tattatcaag atgtcaaagt cgagccttac 2510161 ttcgaccggt tatacttgcc aaacggaatg tgggatgtcc tgggcacggt tgggcaggag 2510221 ctcgcggctg acattttggc gcctcaagac atttcgcaga agctgggaag agaatataaa 2510281 cgactccggg agcaatccga aacacaggga gctgaaaaca atgagtgaga tcgcaaggga 2510341 cgttcatgtg aaacaggtta agccaaaaaa gcagtcctca ctttggtgga tgtacattcc 2510401 tgctttgctc tccgttctgg tctttatgat ttacccgttt gtgaaaggca cattgattac 2510461 ctttacaaac tggaacggat tttcacaagt ctaccaatgg gttggattcg cgcaatatga 2510521 aaggctgttt tctgatcctg atacttggca tatcttaaaa aacacgctgc attacgggct 2510581 tggcagcacc ttttttcaaa atgtggtcgg gcttctgtac gctctcctct taaatcaaag 2510641 cattaaaacg aaagcggtaa caagaacaat tgtgtatttg ccggtgatga tcagcccgct 2510701 cattatgggc tacatttggt actttttctt ctcctatgac ggaggcgcgc tcaacgattt 2510761 gctcggggtc ttcggcatca gccctattaa tgcgctcgcc agtccctcgc tcaatccatg 2510821 gatcattgtc atgattaaca cctatcaata tgtcgggatc gctatggttg tctacttagc 2510881 cggtctgcaa agcattccga aagactacta tgaagcggcg caaatggatg gcgcgaaaca 2510941 aggccagcag ttttttacca tcacgctgcc gctgttaatg ccctccatta ccattaatat 2511001 agtcatcaac attatcggag gcttaaagct gtttgacgtc atcattgcac tcaccgcagg 2511061 cggccccgga aatgcgtcac aatccatgtc cacgtttatg tatgatttgt atttcaaacg 2511121 gcaggatgcc ggctatgccg caacgcaagg catatttatg gcatttgtca ttttgatcat 2511181 cagcttttgc gcgcttgcgt actttaaaag aaaggagacg gaaatgtcat gagagccgcc 2511241 cgtacaaaaa gcatgcggat cattacgctt cttgcagcca ttgtggcctg tgcgcatttt 2511301 attccttttt atatcctgct gaccacttca ttgaaagcaa aaggagacta cagttcgaaa 2511361 tggatatttc cagccgacat ctcctttcat aatttttcag aggcgtggga gcgcgcttcg 2511421 ctaggaaact cttttataaa caccatgatc atcacaggtt tttctgcctt gttattaatt 2511481 atattcggct cacttgccgc ctacccgctt gcccggcggg aaacgaaact gaataaagcc 2511541 gtttttgcct tgctgatttc cattatgatc atccctccgt taacgtccat ggttcctttg 2511601 taccgaatgg tcgtggacgc cggaatggtc aatacacacg caatcgccat tttcatcaat 2511661 acagcggctt acatgccgtt aaccgtattc ttatattcag gctttatccg atcgaccatt 2511721 ccaaaagagc ttgtagaagc cgcaagaatt gacggtgcag gcatgctgaa aatctttttt 2511781 acgattgtgt ttcctctgct gaagccgatc actgcgacca tctgtatcat ttcttgtgtc 2511841 tttatttgga acgactatca atttgccatt ttctttttac aagatcaaaa ggttcagaca 2511901 ttaacagtag ccatggcagg ttttttcgga gaaaacgcaa acaaccttca tttagttgcc 2511961 gcagcggcac ttatggcaat gctgccgatg gttgttctgt ttttggcgct gcaaaaatac 2512021 tttattgccg gcctgtcttc cggagcggta aagggttaac attaaagggg gaagcaatat 2512081 gaaaaagatt acatttatcg gtgcagggag cacgattttc gccaaaaatg ttttgggaga 2512141 ctgcctgtta acagaggcac tgaatggatt tgagttcgct ctttacgaca ttgatcccaa 2512201 acgcctgcag gaatcccagc tcatgctcga aaatctaaga gaccgttata acccaagtgt 2512261 ggccatcaac agctatgatg acagaaaact cgccttgcaa aacgcaggct atgtcatcaa 2512321 tgcgattcag gttggaggat acaaaccgag cacagtcatc gatttcgaga ttcctaaacg 2512381 gtatgggctg cgccagacga tcgccgatac agtaggcatc ggcgggatat tcagatctct 2512441 cagaacaatc ccggtcttat ttgatatcgc aaaagatatg gaggaaatgt gccctgacgc 2512501 atggttctta aactatacaa atccaatggc cactcttaca ggcgccatgc tccgctatac 2512561 caatatcaaa acaatcgggc tctgccacag tgttcaagtg tgcacgaagg atttatttaa 2512621 agctctcgga atggagcatg acggaattga ggaacgcatt gcgggcatta atcatatggc 2512681 ttggcttttg gaagtcaaaa aagacggcac agatttatat ccagaaatca aaaggagagc 2512741 gaaagaaaaa caaaaaacaa agcatcatga tatggtgcgg tttgaattaa tggataagtt 2512801 cggctattat gtcacggaat cgtccgaaca taacgcagag tatcacccgt actttattaa 2512861 acggaattac cctgaactga tcagcgagct gcaaatcccg ctcgacgaat atccgagaag 2512921 gtgcgtcaag cagattgaaa attgggagaa aatgcgggat gatatcgtca ataataaaaa 2512981 ccttacgcac gaacgctcaa aggaatatgg ttcaagaatt atagaagcaa tggaaacaaa 2513041 cgaaccattc accttcggag gaaacgtctt gaatacaggg ctgatcacca accttccttc 2513101 aaaagcggtt gtggaagtga catgcgtcgc cgacagaaaa aaaattacac cgtgcttcgc 2513161 cggagaactg cctgagcagc ttgcagcctt aaaccggacg aatattaata cacagctgat 2513221 gacaatcgaa gcggctgtca cacgaaaaaa agaagcggtt taccaagctg caatgcttga 2513281 tccgcataca agcgcggagc tttccatgaa ggacatcatc tccatgtgcg acgatttatt 2513341 tgcagcacac ggcgattggc ttccggaata caaataaaaa ctaggggacc gctctcccct 2513401 agttttttgg ttttgtttcg ccttcccagg ccatcatgcc gccttcaaca ttgactgttt 2513461 taaagccttg ctcatccagg tacttgcaga cgttcatgct gcgcattcct gagcggcaga 2513521 taaatacgta ctctttgtct ttatcaaggg tttccatttt ttcaggaata tcccccatgc 2513581 gaatatgaac ggcttgcggg atcatgcctt ccgctacctc ttcatcttct ctgacatcaa 2513641 ttaaatataa ttcttcgtcc gcctcaattt tttctttcaa agcggctgtg ctgatttctt 2513701 ttatttccaa agaaaacact cctattcaca gtgatcatgt tcagtatatc aaagtcagcc 2513761 gaacgattgc tattctgaga ctgatgaaaa aaaatcccct tttggcaaag gggatttttt 2513821 ctaggcttag tttgccacaa tattgacaag cttcccaggc accgcgatga ttttccgaat 2513881 cgttttgcct tcaagctgct ctttgacctt ttcatctgct tgagcaagct gttccagctg 2513941 ttctttcgtt gcatcggcag gaacctgtaa tttcgctttt acttttccgt tcagctgaac 2514001 aacgatttca acttcatcat ccacaagttt tgtttcatca tatacaggcc aagcttcgta 2514061 ggcaattgtg ccggaatggc caagcttctc ccatagctct tccgctaagt gtggcgcgac 2514121 aggagaaaga agcttcacga agccttccat atattctttc ggcagttctg ttgctttata 2514181 agcttcatta ataaagacca tcagctggga aatacccgtg ttgaaacgaa ggccttcata 2514241 atggtctgtg actttcatga ccgtttcatg atagacgcgc tccaatgttt cacccgcgcc 2514301 ttcaacgatt tttccattaa gctcaccgct gtcttcaata aataggcgcc atacacggtc 2514361 aaggaaacgg cgcgcaccgt ctaatcctga ttcagaccag gcgattgaag catcaagagg 2514421 tcccatgaac atttcgtaca atctcagcgt atcagcaccg tgagaggcca cgatttcgtc 2514481 aggattgaca acgttccctt tagatttact cattttttcg ttgttttcgc cgagaatcat 2514541 tccttggttg tacagctttt ggaacggttc tttcgtcggc actacgccga tatcataaag 2514601 gaacttatgc cagaagcggg catacagaag gtgaagcacg gcatgttctg caccgccgat 2514661 atacatatcg accggaagcc atttttccaa tttttctggt gatgccagct gatccggatt 2514721 gtgcggatca atatagcgca agaaatacca gcagcttccc gcccattgcg gcattgtatt 2514781 cgtttctctt cttccttttt tccctgtctc agggtctgtg acttccaccc actctttaat 2514841 gttcgcaagc ggtgattcgc ccgttccgct cggtttgatt tcatccgttt ttggcaaaat 2514901 cagcggcagc tcctcttccg ggacagctgt tgacgttccg tcttcccaat gaatgaccgg 2514961 aatcggctcg ccccaataac gctggcggct gaagagccag tcacgaagac ggtacgtcac 2515021 tttcttctca ccgtttttcg tttcttccag ccaagcgatc actttttcaa tcgcttcctg 2515081 tttgtgaagg ccgttcagga aatcagagtt cacgtgctcg ccgtcgccag tataggctgc 2515141 ttcctcaacg ttcccgcctt ttacgacttc cttcaccgga aggccgaatg ttttggcgaa 2515201 ttcaaaatca cgctcatcgt gtcctggaac tgccatgaca gcacctgttc cgtatgatgc 2515261 aagaacataa tccgcaatcc aaatcggcag tttttctccg tttacaggat tgatcgcata 2515321 cgctcctgta aatacgcctg tctttgtttt cgcaagatct gtgcgttcta ggtcactctt 2515381 tgattgaatt tctttgatat aagcttcaac agcttctttt tgctctgccg ttgtgatgtt 2515441 ttccaccaat gcgtgttccg gggcaaggac agtgtatgta gcgccaaaca gcgtatctgg 2515501 tcttgttgta aacactgtaa aggaatcatc atgtccatct atagcaaaat gaacgtgagc 2515561 gccttccgaa cggccgatcc agttgcgctg catatcttta atgctttccg gccaatcaag 2515621 ctcttccaag tcctcaagga gcctgtccgc ataagcggtg attttcagca tccactgctt 2515681 cattgggcgt ctctctaccg gatggccgcc gcgttcgctc ttgccgtcaa tgacttcttc 2515741 gttggcaaga acagtaccga gcgcagggca ccagtttaca ggcacttcgt caacgtaagc 2515801 aaggcctttt tcgtatagct ttaagaaaat ccattgcgtc catttatagt attcagggtc 2515861 agtcgtattg atttcgcgat cccagtcata tgagaagcca agcgcttgaa tttggcggcg 2515921 gaagttatca atattctgct tcgtaaacac agcggggtcg ttccctgtgt caagcgcgta 2515981 ctgttcagct ggcaggccga atgcgtccca gcccattgga tgaaggacat catagccctg 2516041 catgcgcttc atgcgggaca gaatatccgt agctgtgtat ccttcaggat ggccgacgtg 2516101 caacccagct ccagacggat aaggaaacat gtccagcgcg taaaattttt gtttttcatt 2516161 attatcaaga gtggcaaatg ttttgttttc aagccaatat gtctgccatt tcttttctat 2516221 ctctttgtgc tgaaaactca aagtaaaaac ctccttctga ttgaatacgg cgtgtatggt 2516281 tcaagtattg acgggaagga gaggattata ttcagaatat tcccaaacta aaaaaaactc 2516341 cctcatccca aaaagggacg agagactttc gttttcccgc ggtaccaccc tcgttagcgc 2516401 ggcatacgcc gcactcactt gatactttta acgcagttat gcgtcagcgg cttttcaccg 2516461 ctgcaactct gaggtgagtt cggaaacaaa cttgattgac tttcaccagc cgtcaactct 2516521 ctgcaacaat atctgtttct tactgctcct cttcattgtt cttatcgcaa ccgtaatcta 2516581 actgtatttt atagaattct gttcataagt gcaagcaggt ttgtatacaa tgggaatgta 2516641 ccctgaacgg gcggagattg aggacaatta ttcgggtgga gttttggttt gacgtttgga 2516701 ctcggccggt tcgccgccgc tgttcagttc tctcacaaag tcaaaacttc tgagaacagc 2516761 ttcaccgccg tagcctgaga taatggataa gatgacaagt tgaattcctg aatcggggtc 2516821 agcggataat acaagtaaaa tggaagccgt catgccgata aaccaatctt ccaaaaatcc 2516881 aaggtagata aaccgcttcg tcattctggg cttctccagc ctgcctctct ttttcacatg 2516941 accgagaatc cccatgattc ctccaattac acaagcaatg agtacctgat gcagcatctt 2517001 catcatcacc ttcctaaagc ccttatttcg taaagcgact tcaggccatc cagccccctt 2517061 aaacgattcc gatgattttc gatatctaca taccggcaaa tctgtaaaaa gcttgtttct 2517121 tccattatat gtgaacacat gatcggtaag cttgatgcat tggattcatt tttcacccag 2517181 tgacattgac ctagtcacct atttagcatg tagaaaacct ttccgttcat atgttcaaat 2517241 tctgttctta tttttagtgt atacgaggac aagccctaat gacaaacaac aaactgcact 2517301 tgcttgaatc agaacatgtg ttgtgctacg gttactgtag aattcatttt taaaaagggg 2517361 aatatcaggc tttcgcatag caagctgacg gcctaagggg gatttatatg gctagttttc 2517421 aatcatttgg gataccagga cagctggaag tcatcaaaaa agcacttgat cacgtgcgag 2517481 tcggtgtggt aattacagat cccgcacttg aagataatcc tattgtctac gtaaatcaag 2517541 gctttgttca aatgaccggc tacgagaccg aggaaatttt aggaaagaac tgtcgcttct 2517601 tacaggggaa acacacagat cctgcagaag tggacaacat cagaaccgct ttacaaaata 2517661 aagaaccggt caccgttcag atccaaaact acaaaaaaga cggaacgatg ttctggaatg 2517721 aattaaatat tgatccaatg gaaatagagg ataaaacgta ttttgtcgga attcagaatg 2517781 atatcaccaa gcaaaaagaa tatgaaaagc ttctcgagga ttccctcacg gaaattactg 2517841 cactttcaac tcctattgtc ccgattcgca atggcatttc ggctcttccg ctagtcggaa 2517901 acctgacaga ggagcgattt aattccatcg tttgcacatt gacgaatatc ttatcaacat 2517961 ccaaagatga ttatttgatc attgatttat ccggattggc ccaagtgaac gaacaaacgg 2518021 ccgaccaaat tttcaagctg agccatttgc tgaaattgac cggaactgag ttaatcatta 2518081 ctggcattaa gcctgaattg gctatgaaaa tgaataaact ggatgccaat ttttcgtcgc 2518141 tgaaaacata ttcaaatgta aaggatgccg ttaaagtgct tccgattatg taaaaagatc 2518201 ccgctcaccc agctggatct ttcagattgt tgacaaaatc ctaaaatggt tttcatttta 2518261 ggattttgtc atcttttcag cgtgattgaa aacccttgaa gtctaggaag gacgagcata 2518321 ggagcggagc gaatgttcta attcgtgagc accgaagcgc aggcctgaca acgaatgcga 2518381 gggtttgtcg acacgctgaa agatcccgct cattcggcgg gatcttttat tatgaagaga 2518441 ttgatgcctg cttatttgtt tctttagctg attttatccg tttgtcatat agaagcgttg 2518501 tggcaatact gatcagcagc aataccaaca gagataaaac aagagcccta atgccgtaat 2518561 gatcgacaag cactcctccg aacaggggac caatcattct gccgcctgtc gccgcactgt 2518621 tgacaaagcc ttgataaaag ccttctttcc ctttaggggc aagctgattg gcaatagtcg 2518681 gcacagcagg ccaaacaagc atttctccga tagtcaggat caccatcgca gcgagaaaca 2518741 tcggaaattg ctttgcagtc agcagcatgc tgaaagacac aataaaaatg ataaagccga 2518801 tgaccatttg cgcttttagc gactcggccc attttttcac cacaaaactg acgagcggct 2518861 ggccgagcac aatgagaatt ccgttaaccg tccacagcac gctgtataag gaaagagata 2518921 ttccaatgct ttgtgtgtac gaagcaattg tggttgacca ctgagaataa gccagccatc 2518981 cgagtacata gcctccgctt aaaatgatca gtgcggcaaa ttttgctttg ctgttcacag 2519041 catcataatc aagcacggat gtttgggatg catcgcccgt ttgaatattt cgaaatccga 2519101 aatatacaat aaagaaaaag atcagataca atacggcatt tgccaaaaat acatatgaaa 2519161 acgagaaaga tgccacgaca ccgccaagcg ctgaaccaac ggccacgccc gcgttttgcg 2519221 cgacatatat cgcattaaat gccttccttc ccccttcagg ccataccgat cccgccattg 2519281 cgtagcttgc cggaaaaaca acaccggagc caaagcccac aatcgtcagc agcacaatat 2519341 aggctggcca atcatgaaaa aagacaagac ccatcaggct tgctaacgta atggctatcc 2519401 caagcataat cgatttaaaa ccgccgattt tatcaaacaa aaaacctccg cataaattgc 2519461 cagccacact ggcgccggaa ttcagcatca ggacaagtcc ggctactgtt aacgactttc 2519521 ctaaatgatt atggatataa atcgtattca gcggccataa aaaagaagca cccgtcacat 2519581 tgataaacat tccaatgact aaaattttaa gagcacgcgg catactcatc cccctttctt 2519641 acctaaaaaa gctcatgaaa aaaacgaaac ctaaaacggc tccgtacgaa tccagttatc 2519701 atagcacatt cattctatct gtctctctca catttttcaa ctgatgagcg tgaaaaaatc 2519761 taacaaatat tgtttgaaaa atgtaaaata aatagaaaaa ggggtcatat tatggaaatg 2519821 gtattagcat tcttaggttt tctggcatgt ctcattgcac tgggctatgg attatatcac 2519881 cttgtcagat atgtactgaa aaaggaaaaa cgtttctcaa agagactttt ttggccgctt 2519941 ttcattggag gccttgtgct gctctttacc ggggcagcat tggcagaacc tgacactgcc 2520001 gcagcaaatg ccgagaaaaa atattcagcg ctaaacgccg aatataaaaa cctcacaaaa 2520061 gagcacgaag aacttgagaa agaatataaa tctgtcagct ctgaagcaaa gaaattaaaa 2520121 gacaacaaag aagatcaaga caagcttgag aagcttaaaa acgaaaatag cgatctaaaa 2520181 aagactcaga aatcattaaa agctgagatt aaagagcttc aagaaaatca aaagcagctc 2520241 aaagaagatg caaaaacggc aaaggctgaa aatgaaacac ttcgacaaga taaaacaaag 2520301 cttgaaaatc aattaaaaga gacggaaagc caaaccgcca gctctcatga agacactgga 2520361 agttcttcaa acaatacgag taaaagtgat gaaaccaaaa cagctgacaa agcagaaggc 2520421 tgtaatatca aaggaagcag aaacggcatc taccacacgc caggcagtac atactacgac 2520481 cggacaaccg atccggctga aatgttttgc tcagttgaag aagctgaagc cgccggttat 2520541 cgggcgccaa aacgataaac aaaaagctcc agaatgtctg gagctttttc tgtttcacaa 2520601 cgacgattta atgaccttct tataataaag aactgacaga aaaccaaaaa tggagtagag 2520661 cgcagtatat aacaccatca ccataatcat aggcgcccat acctctgatc cgaataagaa 2520721 ccagccggat tggacggcaa agtaactgtg gaagaggccg acaacgagcg gaatgccgaa 2520781 gttgtacatt tgtttgatgc gtatcccctt tatcaggtcg ccctgcgtaa agccgagttt 2520841 tcttaaaatt gtatagctcg gtttttcatc ttcactttca cccatttgtt taaaataaag 2520901 gatacaacct gatgtaatca ggaacgttaa ccctaagaag ccgacgatga acatcaccat 2520961 accaaacagt gatttttgcg cagcgcttgt atctagtctt gataaatgct cgtttttctt 2521021 gttcacctgt tgaaaaagct catttgcttt ttccatttga tcgtcatgtt tcacattgac 2521081 gccgataaat gtagattgcg ccagctgaat gcgggggtct ttatccttgt ccagctgttt 2521141 aaacaggctg tcatccacaa tgacagcggg catgcccccg cttgtaaacg tgtaggacac 2521201 aagaaactct tctcttaatc ctttatattt taatggctgc gtctcgtgct tgctttttac 2521261 tttaataaca ccagagtcct tgaaaaccat tattttttgc agcaagtcgg tgtatcctga 2521321 gaaaacggct tctccagccg ccacatcgac tccttttaca tctttgtcgc taacaacagc 2521381 aagctgcata ttgccgggat cgccctgcat ctctttcgga gttccatcca taatatttgc 2521441 aatgtcaaca tttgcttgca ggacaggtgt tgcctttttt acaaacgaga tgttgctttc 2521501 cctcaatttg ttttcaaata acttggcatc tttctcattc atgaatgaaa aatcagccgc 2521561 tacattttgt tcagcggtct tttccgacga gtaatacgag atgtaagcaa gagataacag 2521621 cccgatggcg agcgctgaaa cggttgtaat aatcgtcagc agcagcgcat tcgatttcat 2521681 tctgaacatg atcgaagaca gtgacagaac ctcagaaata tttaagtagc cgcccttgct 2521741 ttttcgaatg atattcgaga taaacgtaac tgatccttta taaaacaaaa acgtcccgat 2521801 aatgacgctc cccagaatga agctcatcgc aacaaacagt tcattaatgg tcttaaattt 2521861 tccgccaaac agctcagaag acacatagta tcctgtcaaa atcaacacga tgcctaaagc 2521921 gccgatcagc atttggaaaa atgatatttt cttcactttg tcttcagtgg aggacgttac 2521981 tttaaacaaa gataaaatac tctgtttttt gataaacgta taattcatga tcatgatcaa 2522041 aaggtaaatg ccgcagaaca caatgaccgt ttggaccaag gcctgctcag aaaaatgcag 2522101 tttcgcatcc gctttgacat cgacaatttt gaacagaatc atcaagacaa gcttcgatat 2522161 cgaaaacccg gccgctaccc cgatcgctaa tgaaccgaaa tacagcatga cattttctgc 2522221 acttaagatg cgaaaaattt tatgcttcgt cattccaatt aattgaaaca gcccgatttc 2522281 tttactccgt ctcttaataa aaatcgtatt ggcatataaa atgaagatcg ccactacagc 2522341 cacaagcaaa atcgaagcgg ttttaatagc cgcggctccc ttgattgaag ccttcacttc 2522401 gttaattgct ggatcatact gcagcgtgac aaaggcgaaa taaagcgcca cgctaaagat 2522461 gagcgcaaac acatacaaat agtaattccg gagattcttt ttcaaatttc gcaggatgag 2522521 ctgattaatg ttcatgctgc accccgccta acacgccttg cgttttcata atatcctgga 2522581 aaaacgtttg cctgtcctgg ccccctttat tcagctgtgt atacatttgc ccgtccttaa 2522641 taaaaatgac tctgccgcag tagctggcag cgacgggatc atgggtaacc ataataatcg 2522701 tcgcgttgcg tttttgattg agctggctca gcttatttaa tagatcggag gccgatttcg 2522761 aatcgagcgc gccggtcggt tcatcagcga aaataatgct cgggtcatga ataaacgctc 2522821 ttccagcgga tgttctctgc ttctggccgc cggaaatttc attcgggtat ttatcccgca 2522881 attcatatat tcccagttcc ttggcaactt cctcaaactt gcgattggct tccttttttg 2522941 atagtttcgt gatcgataaa ggcagaagga tattctcttt cactgtcaat gtgtctaaca 2523001 aattgtaatc ctgaaagata aagcctaaat gctgttttct aaattcagcc agctgctttt 2523061 ccttcatagc cgtcatgtca tttccattaa tatgaatggt tccgtgactg acctgatcga 2523121 ttgaggacag aacgttgagc aaagtggttt ttcccgaccc ggaagcaccc ataatactga 2523181 cgaattcgcc cttttcaatg tgaatatcga tgcccttcag cacttcctgt ttattcagct 2523241 tgtttccata actttttcga attttattcg cttctaaaat caccatttac gcagtctcct 2523301 ttatattgga taatctcatt ataaaaagga atgccgggct tttccttcga tacggcgaac 2523361 aaaaaagaaa agcatgtgac attttcgtca cacgcttatg acatgttcaa attgattccg 2523421 tattggaaag gttaatgtaa aaactgttcc cgcaccaaac tccgactcaa catcaatatg 2523481 gatcaataac ggcgccgctg ctttttttgc caagtacagc cccatgccag ttgacgcttg 2523541 atcatggtga tccgttgtgg atgtaaaccc tttatcaaaa atacgcggta catcttttgg 2523601 atcaatgccc ctgccacaat ctttcacttg gagctgcgtc tgttcccctt tttgaaagct 2523661 tttgatctcg atttcagagg cttcgctgta tttcaccgcg tttgtcagca gctgcctgat 2523721 gataaacgcc agccattttg catcgctcag cacttctttg gcctcgagct gtatgtcaaa 2523781 accgatccct ttttggatac accacgattg taaatctttg atttctttaa agatcaaagg 2523841 ctgaagctga atgaattcta ctgacaggtc gttttcaata aatgaaatgc gtttttgatg 2523901 aagctgctga tcaagaagca ggtgaatacg cagccattca tatgacagct gggatttcag 2523961 tgctttttct tccattctat caatgattaa atgcatcgct gttaatggag ttttgacctc 2524021 atggatccat gccatcagct catctttttc attttccaat gctaagcgat gccgtgctgc 2524081 ggtctgcttc aagtgttctg tttgcccggc aatgcttctt tcaaccattg cttcaaacgg 2524141 cgtttccggt tcatttatgg ctgtcacatc gagattgttc tcccatgttt tcaagctttt 2524201 ataaaacgct gtttctttcc gatagcggaa ccaaaggaat atgataaaaa acaagatgca 2524261 caaatacacc atataaagta cattcccaaa tgatatggaa ggatcgacaa aagcaatgaa 2524321 cagcatcaaa gcctgctgaa acaaaaacgc ggcaatccag ctccgccttt cgataaggaa 2524381 tgctttaatc atagaacttg tcctcttcct tcgcgatgta gccctggccc acctttgtct 2524441 cgatatatgc accaagctgc agggcgtcca gtttttttcg caggcgattg acattgacgg 2524501 tcagcgtatt atcactaaca aaacgctcat cgttccacaa gcttctgatc agctcttccc 2524561 ggctgacgat cttgtttttt tgctctatta attgttttag aatgaacatt tcatttttgg 2524621 tcagttcaac agatcctttg tcattgctga cgaggttctg ctccgcgtct acagcagcgc 2524681 cgcaccacgt tttaatcgta ctcggctccg tattataatg gtgcacacgc cggaacatcg 2524741 cttggatttt cgcgatcagc acatcaaaat gaaatggctt ttgaataaag tcatctgccc 2524801 cgagctgcat ggacatcacc atatcagcag gatgatcccg ggaggataaa aagagaatcg 2524861 gaacatttga ccgggagcgg atcagacggc accaatgaaa gccgtcaaat ttaggcagct 2524921 gcacatcaat aatgacacaa tcaggattaa ccgccgcaaa ttcctgcagc acctgactga 2524981 aatcctgaat gccgtataca tcataggacc atcccgttaa acgatccttg atttcatgaa 2525041 acagcgattc atcatcttca atcagcaaaa gtttaaacaa tcgactcacc gcactttttc 2525101 cttttttatc aagtgtatag caaaacgcca gcatgcgcta tagaaaaagc cggctgtctc 2525161 agccggctcg ttcgcattat aattctcttc tcaacgctgt cagcacgttg gttttggtag 2525221 cttttctcgc cgggttcatt ccggaaatga ctgcgacccc tccgcaaatc acaacggcaa 2525281 tgatcacaag gctcgccggg atgtaggaga atgtgtaatt caaatcgccc gcatcgccac 2525341 cgcttgtggc cgcaagaatc atcggaacgg ccaggttgac aaggtagctc acgccgtaag 2525401 aaatgataat cccaatcaca cagcctaaaa ttccgatata cgcgctttcc atcaagaaca 2525461 ttcggcgaat gattgacggg ctcgccccaa tcgctttcat aatgccgatc tcttgcgttc 2525521 tctctgtcac cgccatcgtc atcgtgttaa aaatgccgat cgctgaaatg ataactgcga 2525581 tacatccgac aaagatcagt ccgattttga agaccatgaa gaaggtattg gctccctcaa 2525641 gttcagtagt cactgatgtg acatagtacc cgtcatctgt tagatcattt gtcagctgtt 2525701 ccacattctc aaacttatca gcaaaaacac caatgttcgt ttcaacattt ccgcctttga 2525761 aatctaagaa ttccgaaaaa tcttttttga attgatcact gataaaaata tttgagtcct 2525821 ccatccagtc ttgagatggt ttttttgtaa taccgacaat tttaaagtca tatgtttttg 2525881 tttttgtaac atcccctgtt ttagaatctg tcttcgatac acttagttca attgttttat 2525941 ttagaatatc tttcgtatag ccctttggtt cttttatatc ttctggattt ccttttgctt 2526001 cctcgatttt tttgttatat tcttccgatt cttttttcgt taataatctc tttgcgaagt 2526061 cgtatcctac tacgatttca ttttccgact ttgcgactct tcccttttcc aattccatat 2526121 tggcctttaa ttcatcattc atattagtaa aaatgagatt tgagctttca tttgtacgat 2526181 tgcctaaagt agctttgttt ggttcataca cttgcgttct ttctacaact gaccttacgt 2526241 gatcatactt ctctaaatca gcttttttaa tcggcttgtc tccttccttg cccattacgc 2526301 tgactttcgt tacaatctgc tggctcattg tcatatctgt aatcgtcttt tgaatcccaa 2526361 atccaacgga cgacaacaca accaaaaacg cacacgccat tgttgtcgcc agaatcgtca 2526421 taaagacgcg aagcctgttt ttcttcatat ttcttctgat aaaatgaacc tgatccttaa 2526481 acctcaacgg taattcctcc ttttagcaca ccatcatgaa gctgaaattt tgaatgtccg 2526541 atagaagcga cttcatcatc gtgagtaatg atcacaaatg taatgccacg ctcacgattc 2526601 agctgctgga tcaattccag cacttcatgt tccgtttctg aatcaaggct tcccgtcggc 2526661 tcatccgcta agataatcga aggatttaaa atcaatgctc gagcaatact gacacgctgc 2526721 tgctggccgc ctgacagttc attcggataa tgagcggcgt ggttttccag accgacgcgt 2526781 ttcagcatgt cctgcacctt ttgcttccgc tcagatggct tgattccttt taacgccagc 2526841 ggcatttcca cattctcata cgtcgttaaa cccgggatga gctgaaagct ctgaaaaata 2526901 aacccgaaat ggtcaagccg aaattgcgcc cattcctttt cattaaaccc cgtaacatca 2526961 gtgccattaa tgacaatccg cccttttgtc ggcgatatgt agccggaaat taaattcaaa 2527021 agcgttgatt tccctgagcc gcttcgtccg acaatgcagg cgatttcccc tttcgccacg 2527081 ctcaatgaaa catccttcaa tactggaact tcattctcac ggcccttttt tccgatcgtg 2527141 aaagaatggt cgatatgctg aacatcaatc atatgttctc tctcccttac aaaagtttca 2527201 tttttttata aatcgcaaaa taactaatca agaaaccgat taccgcacct gtacccatgc 2527261 caatgagata accggcaaag ctctcgcttg cagtaaatcc aaaatagccg aagcccatga 2527321 ttcctatgat aataacgatg atctgcaccg ggcggttaag cggcttccat aagaagaaat 2527381 atccgtttct ttcattagac attttaacaa agctaatata gccgatgatg taaaaaatga 2527441 tagtcatgat agccggaatg actaaataat atggtgaatt ctcagcccat ttcgagtcta 2527501 cataaattat cggaatgaaa tactgcaccc atttaggtac tggaccatgg ataaaatcta 2527561 ttgatccgcc aaaaaggatc tcgaggttga tcacaggcag gctgatgagt aaaaacggcg 2527621 aaatggccac ggtaaatgag actagaagct gtgcgaaact attgcctgtc aaagctcctc 2527681 cggccataac caaagaataa gccagcatgc taacaataat cattcccaag ctgtaattgt 2527741 gaaaataaac ggcctgatct ggcttcaaaa gcatgatcag caaaacagac aaaacataac 2527801 ctatgagctg cggcaccaca atcaccattc cgccggtaag gaacttcgca tgaaatatct 2527861 gccctcgtgt atatggaagg cttaatgtaa aatcaaagaa gctcttgcta cgttcaatcc 2527921 caagctggct gaccgccaaa acgactcccc aaatccaaaa caatgagata aatgagctat 2527981 ttaaataatc aacgctgaat acgcaggggc cgacccaatt ttcttttcca gtgacacagc 2528041 cttgatagat gagatacata tttaaaattg ataatggatt acctaatata aaaaccaaaa 2528101 tggtgataac taaggcgact ttattctgcc gccactcttt gtaaagcagt ccggaatccg 2528161 gcaactcact tccctccaaa cctaaggcat ttcttacact tttgttttct tataaataga 2528221 gaagtagctc acaaagaatc cagccactgc tccaatgatc atacccaaaa tataaccaat 2528281 aatggaatgt ccggtatagt atccaaataa accaaatcca aggatgccga aagccataac 2528341 cagaatttgc accgggcgat ctaatctgtt ccataagaaa aagtgtccgt tccgttcact 2528401 tggaagcttc ttgaagctta taaagccaat caagtaaaat agcatgctca ttacggctgg 2528461 aatcaataaa agatatttac tgttaatcag ccattcattt acaacgtaac taatcggtac 2528521 taggttcgat aaattgcttg ccagagagaa ataactctca ggggaaggga atatttccca 2528581 tatattcgca ccaaaaacaa cttctaggtt tccaaccggc aatgcaataa ttaaatacgg 2528641 caatatagct gctgaaaacg ccgttaacag ttgggcaaaa gcatttccag ttaacgctcc 2528701 ggcggccatc accagtgaaa aagccataaa acttatcacg attactccaa tgctgctgtg 2528761 ctcaaaaaag tagacgtgtt cagggttata gacaagaatc agcagccatg caagtaaaaa 2528821 gccaatcaat tgtgacagca caatcacaaa accgcctaac caaaattttg tctgaaaaat 2528881 ttggcttctg ttatacggga ggcttaatat aaaatccatc gtgcctttcg aacgctccat 2528941 tccgaggaag cagaccgcca aaatgacacc cggcacccag ttgatatcta tcagattgct 2529001 tatggaataa ttcacaataa aatcacaata ttgcgggtct tggcgatcaa gacacccttg 2529061 ataagacaaa tacgtattaa cgatagaaag cggatttgcc aatactaaaa acgcgatact 2529121 taacaaaatc accacttgat tctgcttcca ctctcgatag aggagacctc ggtctaccat 2529181 ctccgcttcc ctccaaactt cgcaatgaac acttcttcca ggttgacagg aagctcattc 2529241 cacacttttg gcttcagctc tctcaaaaag ctctttttct cctcatcgct tttcggaatc 2529301 agcactgtgt aaaacacgcc ggcctgatcg agcatcggaa tgttttgctc tctgatggcc 2529361 aaattgacat ctgtatcgaa ggccatttga attttaatgt attcttcttt taactcatca 2529421 agatccatga cgttggtcag gctgttatct tcaagaaaac caattcggtt gcacatccgc 2529481 tctatgtctt caagccggtg ggacgtaatc aggatgctcg tatcacgctc tgccacttca 2529541 tcgaccatca gctgcagcac atcatgcctt gtcaccgcat caataccatc cgtcggctca 2529601 tcaaggagga tcagcgccgg tctcgccgca aacgacagaa cgagcgatag ctgctttttt 2529661 aagcctgtcg acagctcacg gtattttttc gtttccggaa tttcgtatct gttcatcagc 2529721 tcattcgcgt acgtgacatc aaatttcgga tatattcttc tcaaaatatc gactaactgc 2529781 ttgtatgtat acttatcgta aaacggattt tgaacaggca tgtagatgat attttgtttg 2529841 actttcgggt gctttttgat ttctacgccg tcaaataaaa tcgttccgct gtcagcgaaa 2529901 atgatttgct ggattaagcg aagcatcgtc gttttgcccg atccattgcg tccaagcaat 2529961 ccaaagattt ctcctttttc gattgttaat gaaacatctt ttaatacttg attgccgtca 2530021 atcgcttttg acagctgccg cagttcaatc attttttttg cctcccttca catcagcgct 2530081 gatttccttt atccattcgt gcagtttttc cagctcaacc cctgcatagt gtgcatcgat 2530141 gatgagctgt ttgagttgct ctttaatcat cgtcatcttc ccttcaacca gtgtcgtttt 2530201 tgcattctcc gatatatagg tccctctgcc ccgcagcgtt tcaataatcc cctctcgctc 2530261 aagttcttta tacgctttgc tgacagtgtt cggattcgca ataatgatcg ttgccaattc 2530321 tctgacagaa ggaagcttat caccaggctt catgatccct ttcaaacaaa gctctttcat 2530381 ttgctgaata atttgttcgt aaatgggtgt tgagcttctt ggatcgattt gaatcattta 2530441 cttccctact ttctatacga tctgaacctt ttatagataa aaatgatcaa ttatactttt 2530501 ttgccattca aaaccgatca tcacaagaac aagaaaaaaa gaacaagcga tcacagatgc 2530561 cgcaatcagc attggcacgt tacgtttgtt tcgtttttta tgtttcataa ctgcctccct 2530621 taatgtcaat atataaatga ttttatatta gtgtctatag tgtattactt caattagtac 2530681 acttaataca ataaatactt tgactcacaa agtcaatcct ttttttacaa aaaaacggac 2530741 ccttttaaaa gggtccgttt tcctacacat caagagggtg ctgcaggatc atattatttt 2530801 gcaaagattg aagctgaagt ctcattctgt acagctgttc tctctgctga tcatttgacg 2530861 acagccatag tttattcaag gcatttaccg catcttctag ctgcatttgt gcatcactat 2530921 attcttgatc gttataatgc tcttgtttag aagcgatttt cagctgttct tcagcataat 2530981 cataggcctg catacattgc tggagatgtt catctactga ttgtcttgtt gccacagtaa 2531041 cccctcctct tggtaatgga aatcatccat cattcatatt gtagcctcat ctgactttat 2531101 tcaataaagt aatttatggt cgatattcat ttgttctctt gtgaaatgcg tgctacaatt 2531161 ttaggatgca atcgtacgca aggaggcaca tgaattgtga tgcagaacaa tccttttcct 2531221 tattcaaata cggaaaaacg ctatcataca ttgaattatc atctcagaga acatttcggc 2531281 cataaggtgt ttaaagtagc gcttgacggc ggttttgact gtccaaatcg ggatggcacc 2531341 gtagcccacg gaggctgtac gttttgcagc gcagcaggct ccggagattt tgctggaaac 2531401 cggaccgatg atttaattac gcaattccat gacatcaaaa accgcatgca cgaaaaatgg 2531461 aaggacggca agtacatcgc ttattttcag gctttcacaa acactcacgc cccggttgag 2531521 gtgcttcgtg agaaattcga atccgtcctc gccttagatg atgtggtcgg catttcgatc 2531581 gccacacgcc cggactgtct gcctgatgat gtcgttgatt acttggcaga gctgaatgaa 2531641 cgtacgtatt tgtgggtgga gcttgggctt caaacagttc atgaacggac tgcacttttg 2531701 atcaaccgcg cacatgattt taactgctat gtggaaggcg tcaataaatt aagaaaacac 2531761 ggcatacgtg tctgctcgca tattatcaac gggctgcctt tggaagaccg ggacatgatg 2531821 atggaaacgg caaaggccgt cgcagatttg gatgtccagg gcattaaaat ccatctgctt 2531881 cacctactga aaggcacgcc gatggtcaaa caatatgaaa agggcaagct ggaatttctt 2531941 tctcaagatg attatgtgca gctcgtctgc gatcagcttg agatcattcc gcctgaaatg 2532001 atcgtccacc gcattacagg tgacggaccg attgagttga tgatcgggcc aatgtggagc 2532061 gtcaacaaat gggaagtgct tggcgccatt aataaagagc tagaaaatcg aggcagctat 2532121 caaggaaagt tctttcaacg gcttgaggag gaatcagcgc tatgattttg aagaaaattc 2532181 ttccttacag caaagaactg ctgaaaatgg ccgcgggaga gggagatatt gtcgtagatg 2532241 cgacaatggg caacggacat gatacacagt ttttagcgga gcttgtcggt gaaaacggcc 2532301 atgtatacgc attcgacatc caagaatcag ccgtggccaa tacaaaggaa cggctcggtg 2532361 acatgtatca agcgcgaaca acgttatttc acaaaagcca tgataaaatc gctgaatccc 2532421 tcccgcctga aacacatggc aaagtggcgg ccgcggtatt taacctcggc tatttgccgg 2532481 gcggggacaa atcaattacg acaaacggca gttctacgat caaagccatt gaacagcttc 2532541 tcagcatcat gaaagacgaa ggtctgattg ttctcgtcgt ctatcatggc cacccggaag 2532601 gcaaagctga aaaaaacgac gtgctcgagt tttgccggga cttggaccag caaacagccc 2532661 gtgtattaac atacgggttt atcaatcagc aaaatgaccc gccatttatt gtcgccatcg 2532721 aaaaaaaagc tcagatcagc aaatgatttg agcttttttc tttgaatttt tcatccagga 2532781 cattttttga aatttccggt aggctctgcc gttgatataa aagaaaaggg aggtttttcc 2532841 gctggctttg atcagcttct ttgcgagccg gacctgcttc gtcttacttt accatttttc 2532901 aaattatatt tgaaagcaat aaccatcgtt aacccggacg tcatacagtt cgggtttcga 2532961 tttttccata aaacgttcac atatagcatg aaacgtatga cttttatctt atcacaaaac 2533021 tataaacagc ctctgcaaaa acacatacct attctttcct gttctctatt ttctatgagc 2533081 acacacaaaa agagcccact gggagctctt tttgtcagct gatatttcgt tcgctggcag 2533141 cagccgcatt ttttttatga aacccttttc catagtacac agccagcaag atgagaaacc 2533201 atatcggccc gataatcacg gctactcttg tatcagggct gtaagccata agaatgacga 2533261 cgaatgctag aaatgccaat gacacataag acgtaaacgg aaataaaggc attttgtact 2533321 ttaattgttt cttttcttcc ggcttcaaac ttttcctgta ttttatttga gaaagcaaaa 2533381 tgattgccca cgtccaaatc gctccgaacg tcgcaatact tgtaacccaa gtaaatacct 2533441 tcgcagggac aacatagttt aacagcactc cgactaataa agcgcccgct gaagccagaa 2533501 cagctttacc cgggatgccg cctttcgtca gctgaccata tgcttgtggc gcctctttct 2533561 gttccgccaa gttaaacagc atccgccctg tgctgaaaat accactgttg catgaagaca 2533621 gcgcggctgt caacacgaca aagttaatga tacctgcggc cgatggaatg cccacttttt 2533681 gaaatgtgag aacaaatgga cttccttgag agccaatttc ctgccacgga taaatagaca 2533741 taatgacaaa taaagcgcct acataaaaaa tcaaaatccg ccaaaatact gtatcgattg 2533801 ctttggctaa cgatttttgc gggtttttta cttcgccagc cgtcaccccg atcatttcaa 2533861 tccctaaata ggcgaacatg accatttgaa gagacaataa aacccctttt aatccatgag 2533921 ggaaaaatcc tccgttgttc cacaaattgc tgattccggt tgcaatgccc ccattgccga 2533981 ctcctgcaat aatcatcaat aaaccgacag caatcatgga taagattgca acaattttaa 2534041 tcaatgcgaa ccaaaattcc agctcgccgt aagctttgac agccaggaaa ttaacacccg 2534101 tcataatgac cagtgccgat aacgcccaaa tccagtttgg cacgtccgga aaccagaacc 2534161 ccatatagat gccgacagca gtgatttcgg ccatacaggt gacaacccat aaaaaccagt 2534221 agttccaacc tgttaaatag cctgcaagcg gtcccaaata atcacgcgca tacctgctga 2534281 aggagcctgc gaccggtttt tgaatggcca tttccccaag cgctctcata ataaaaaaca 2534341 tgaccaggcc gcttgcggca tacgctacca aaataccagg ccctgctaat tgaatagctg 2534401 atgcggagcc gaggaacaac cctactccta tagcagctcc taaagacatt aaagaaatat 2534461 gcctttcttc gagtccgcgg tgcagctctt gtttttgttt ttgcatgctt cttctcccct 2534521 agaaaaaaat atcattatat catttttctg aatattccgt acggattggg taaatcaatg 2534581 atgatggaga aataaaagga taacaacaag gctttcgact actcgaaagc cttgttgtct 2534641 gttacacaaa gatgacttct ttaggctgat ggctcagctc ttcaggcata taccgttttt 2534701 caatattgat gctgtgccag atcataaaga ttagcacagt ccaaatttta cggctgttat 2534761 cagccttgtc cgcacaatgg tcttcaagaa gctgaaggac ataatcctta tggatataag 2534821 catccgtttg gctttcttga ataatattcc gcacccattc gttcatttcg tttttcagcc 2534881 aatgacggat cggtacaggg aaaccaagct ttttgcggtt taatacgtgc tcaggcacaa 2534941 ttccttcagc ggctttgcga agaagatact tcgtcgtgcc gttcttcgtt ttcagctcat 2535001 caggaatttt tgaagcgacg tcgaatacga ctttatccaa gaacggcaca cgcagttcca 2535061 aagaattcgc catcgtcatt ttatccgcct ttaacaaaat gtcgccgcgc atccaagtgt 2535121 ggatatcgac atactgcatt ttgttgatat cgctgtacga gctgctttct gtaaagtaag 2535181 tcttcgtcac atcgcgatat gaaaggttcg gattataatg cttcaacagc tgctttttga 2535241 cagactcttc aaagattttc gcgttaccga tataacgatc ctgaagcgga gtgcagccgc 2535301 gctcaagcag gctcttccct ctcatacctt caggcataac ggcagcaacg tgcagaagca 2535361 tctttttcaa gccggacgga atccgttcaa acggtttaag cgaaagcggt tcacggtaaa 2535421 tgttatatcc gccgaagagc tcatccgctc cttcacctga taaagcaacc gtaacatgtt 2535481 tttttgcttc ttttgcaaca aagtacaacg gaatcgctgc cggatcagca agcgggtcat 2535541 caaaatgcca tacgatcttc ggaagctcat tcatgtattc ctcaggcgaa atgactttgc 2535601 tgatattttc aatgcccagc gccgctgccg tttctttcgc tacatcaacc tcactgaagc 2535661 cctgctgttc aaagccgaca gagaatgttt ttaagcttgg atgaaattcc ttcgcaacag 2535721 acacaataaa ggaagaatca atcccgccag acaggaacga accgacagga acgtcacttc 2535781 tcatatgaac gtttacagag tcatagatcg cgtctcggac ttctttcaca agcttgtctt 2535841 cttcagtctg aaccggcttg aagttcgctt tgaaatacgt tttgaatgtg atatcgccgt 2535901 ccgggcggat tgtgaattgt gaacccggct ctactttttt cacatgggca tcaagcgtgc 2535961 ttggttcagg aacaaattgg aaagacatgt actgctgcaa tgcctcttta tctatttcaa 2536021 tatcattctg agcaaccatt aaactttttc tctctgaggc aaaataaacc tgatcattga 2536081 tcgttgtgta gtacaacggt ttaatgccga atggatctct tgccccataa agcacatgat 2536141 cgtttttatt ccaaatcaga aaggcaaaca taccgcgcag tttggacgcc gcttcttctt 2536201 tatagtgacg gtaagtcgca agaagaacct ctgtgtccga atccgtgttg aatgtgtacc 2536261 cctttgcttc aagttcttct ctcagttcga tatagttata gatttctccg ttaaagataa 2536321 tccaatatgt ttcatcttca tatgataaag gctgtccacc attttctaca tcaataatgc 2536381 tgagccgtct gaatccgaag ccgacgtgct catcatggaa atatccatca ctgtcaggac 2536441 cgcggtgaac gatcatttgg ttcatttgtt tgattagttc ttcttgatca gcggtttgag 2536501 ctaacggatg cttgttaaaa accccgacaa atccacacat agtattgcct ccataattaa 2536561 aattgtcatc attgaacccc tatttataga cgctgtgaat agtatttggt ttcacagtta 2536621 tgtaaaaaaa taaacatgaa tacaacgata aaaaagggaa agccgcttaa ccagtaagcg 2536681 gctataaaat tattctccta acgcttcttt acgcagctgc tccgctttgt ctgtgcgctc 2536741 ccatggaagg tcaacatcgt gacgtccaaa gtggccgtac gcagcagttt gtttatagat 2536801 cggacggcgc aaatcaagca ttttgataat gccggcaggt cgtaaatcaa agttattgcg 2536861 aacaacttca atcagttttt cctcagaagc ttttcctgaa ccgaatgtgt tgattgagat 2536921 tgacacaggc tgtgcaacac cgatcgcgta agcaagctgt acttcgcaag aatcagcaag 2536981 ctcagccgca acgatgtttt tcgcaacgta tcttgccgca taagctgcag aacggtctac 2537041 cttcgtcgcg tccttacctg agaacgcgcc tccgccgtgg cgtgcatagc cgccgtacgt 2537101 atcaacgatg attttgcgtc ctgtaagtcc cgcatcccct tgagggcctc cgattacgaa 2537161 acgtcctgta gggttgatga aatattttgt ttcttcatca atcagctctt caggaacaac 2537221 cggattgatt acatgttctt taatgttgcg ctgaatttgc tcaagtgtaa tttcagggtg 2537281 atgctgagtt gaaataacaa tcgcgtcaat gcggactggt ttgttatttt catcgtactc 2537341 aaccgttacc tgtgttttgc cgtcagggcg aaggtacgga agaatatctt ctttacggac 2537401 ttcacttagg cggcgggcta atttatgggc aagtgaaatt ggaagaggca taagctcttt 2537461 cgtttcgttg cacgcataac cgaacattaa tccttggtca cccgcaccaa tcgcttcaat 2537521 ttcttcgtcg ctcattgtgc cttcacgggc ttcaagcgct tggtctacgc ccatcgcgat 2537581 atcagcagac tgctcatcaa ttgatgttaa aaccgcacaa gtttccgcat caaatccgta 2537641 ttttgcacgt gtgtatccga tttctttaat ggtttggcga accgttttcg gaatgtcaac 2537701 atacgtagaa gttgtgatct ctccgcttac aagaaccaaa cctgttgtca cagatgtttc 2537761 acaagcaaca cgcgcgttag ggtctttctt taaaatttca tctaaaatgc tgtcagaaat 2537821 ctggtcacag attttatccg gatgcccctc cgtaacagat tctgatgtaa ataaacgacg 2537881 atttttactc atgatttgct tcctcctgca caaggcctcc cgaaagacct tgtatatatg 2537941 atacggaact cgctccctct tatacaatgt acagttatat tagagaatgt taattggcat 2538001 atttatgaaa taaaaaaacc ttttccatcg aggaaagggt ttggtctttg tgcctttcac 2538061 tcttatcgct caaggaatca tacaaccttg caacaggtta gcaccttggt tgtctcactc 2538121 agttgaacat aataaataac agagaaaccg gttgctgggc ttcatagggc ctgtccctcc 2538181 gccagctcgg gataagagta tccgctcaat gaaatatctt atcgtaaaag ggtttgcaat 2538241 gtcaatatga ttcagaagaa ataggcacct atattgaggg aaaacaatgg aaatgcacac 2538301 acaaaaaaca ataaatagta tagactattt gaaaatatat gttatactaa ttcacaatta 2538361 gcaaaacaca aaaaacgata aaggaaggtt tcatatgaac tcagttgatt tgaccgctga 2538421 tttacaagcc ttattaacat gtccaaatgt gcgtcataat ttatcagcag cacagctaac 2538481 agaaaaagtc ctctcccgaa acgaaggcat tttaacatcc acaggtgctg ttcgcgcgac 2538541 aacaggcgct tacacaggac gctcacctaa agataaattc atcgtggagg aagaaagcac 2538601 gaaaaataag atcgattggg gcccggtgaa tcagccgatt tcagaagaag cgtttgagcg 2538661 gctgtacacg aaagttgtca gctatttaaa ggagcgagat gaactgtttg ttttcgaagg 2538721 atttgccgga gcagacgaga aatacaggct gccgatcact gtcgtaaatg agttcgcatg 2538781 gcacaattta tttgcgcggc agctgtttat ccgtccggaa ggaaatgata agaaaacagt 2538841 tgagcagccg ttcaccattc tttctgctcc gcatttcaaa gcggatccaa aaacagacgg 2538901 cactcattcc gaaacgttta ttattgtctc tttcgaaaag cggacaattt taatcggcgg 2538961 aactgagtat gccggtgaaa tgaagaagtc cattttctcc attatgaatt tcctgctgcc 2539021 tgaaagagat attttatcta tgcactgctc cgccaatgtc ggtgaaaaag gcgatgtcgc 2539081 ccttttcttc ggactgtcag gaacaggaaa gaccaccctg tcggcagatg ctgaccgcaa 2539141 gctgatcggt gacgatgaac atggctggtc tgatacaggc gtctttaata ttgaaggcgg 2539201 atgctacgct aagtgtattc atttaagcga ggaaaaggag ccgcaaatct ttaacgcgat 2539261 ccgcttcggg tctgttctcg aaaatgtcgt tgtggatgaa gatacacgcg aagccaatta 2539321 tgatgattcc ttctatactg aaaacacgcg ggcagcttac ccgattcata tgattaataa 2539381 catcgtgact ccaagcatgg ccggccatcc gtcagccatt gtatttttga cggctgatgc 2539441 cttcggagtc ctgccgccga tcagcaaact aacgaaggag caggcgatgt accatttttt 2539501 gagcggttac acgagtaagc ttgccggaac cgaacgtggt gtcacgtctc ctgaaacgac 2539561 gttttctaca tgcttcggct caccgttcct gccgcttcct gctcacgtct atgctgaaat 2539621 gctcggcaaa aagatcgatg aacacggcgc agacgttttc ttagtcaata ccggatggac 2539681 cgggggcggc tacggcacag gcgaacgaat gaagctttct tacactagag caatggtcaa 2539741 agcagcgatt gaaggcaaat tagaggatgc tgaaatgata actgacgata ttttcggcct 2539801 gcacattccg gcccatgttc ctggcgttcc tgatcatatc cttcagcctg aaaacacgtg 2539861 gaccaacaag gaagaataca aagaaaaagc agtctacctt gcaaatgaat tcaaagagaa 2539921 ctttaaaaag ttcgcacata ccgatgccat cgcccaggca ggcggccctc tcgtataaaa 2539981 aacaaaagcc aagagcaatt atgctcttgg cttgttttaa ttgacggaat gcaaagaagt 2540041 cagcttgtat gtaatgatgg tccggccttc ttcccattga agcttctgca cttcagctgt 2540101 gcctgacttt tcgccaaact ttgttttgcg tacatccatt ggaatctcca tcggatatac 2540161 tcggtatccg tccttctcta acgtgaatat attttcatct atgcgaactt cttttccttt 2540221 tgtcacaatc agtgtattaa attcaacagg cattcccaaa gtgaaatccc ctttcgttct 2540281 cttttttctt tatcataaca tatttcactg tcagcggttt ttcatccatt gtgtgagctg 2540341 ccgcacgata cgccggtttt cttttggcgg gaaataatgt gtgaatgtac tgtagtacca 2540401 tgtttccacc ggcttatgca gttgttttag cttctcttct aataaatagg aatgctgaat 2540461 cgaaacattt tggtcttttt ctccatggat taacagcacg ggagcctgaa ttttgtttac 2540521 ttggtcaaac ggtgtcctcc attgatattc ctcaggcacc tttttcggtg ttccgccgat 2540581 gactcttttc atcattcgcc gcaaatcctg ccgctcctcg tatgtaagaa tcatatcact 2540641 gacgcctccc caggaaacaa atgaagctgc ctgcccgccc atttcgatcg cagtgagcat 2540701 tcccataatt ccgccgcggg aaaaaccgaa gatatggatt ctatccttct tgacatttgg 2540761 gtgctgctga agcaggcgaa aagcagaaaa tgcatcctcc ctgtcttctc cggcaaaatc 2540821 ctcattgcct tctcctcctt gattgcctct gtaaaaagga gcaaacacca caaacccttg 2540881 ggatgcaaac tggataatcc ggcccggccg aaccatgccc acgcttttaa tcccgccgcg 2540941 caaatataaa aatccgtcat attgtcccgg ttccgccggc tcagccagaa gccccttaac 2541001 ccgtaatcca tttgacagat agcagatcgt atacaaacgc acatgctggc ttggcgacgg 2541061 aaatcttctt ttctctacaa tcaaaacagc cgcctccttt tttctatatg ctttccttac 2541121 tccaaaatta catccggaga acctggttag gcattcacac atttttatac ccatcatacg 2541181 atatgtaaag caaaaaagga tattaacttg atgcgaaata aggaggttgt ctatgtgaac 2541241 agatggttaa ggctgggctt cgcctgtgtc ggcagtatct ttctgatgtt cgccctggcg 2541301 gcttgcaagc aggaagaaac gctcaccaaa gtcaaagtag ctgaagtgac ccattcaatt 2541361 ttttacgcac ctttatatgt tgctgagtct aaaggttttt ttaaggaaga agggcttgat 2541421 gtcgatgtga atacgacctg gggcggagat aaaacgatga catcgcttct ttccaacggc 2541481 tccgacatcg cgcttgtcgg gtcagaaaca tctatttatg tcgaagcgca aggggctaaa 2541541 gatcccgtca ttaatttcgc ccagctgact cagacagacg gaacgtttct tgtcgcgaga 2541601 gaagatgttg aacacttcga ctgggatcag ctgaaaggaa aaacgtttct cggtcagcga 2541661 aaaggcggca tgccgcaaat ggtcggcgag tatgtactga acaaacataa gattgacccg 2541721 cataaggata tagacctcat ccagaacata gacttcgcca atattgccaa tgcgtttgct 2541781 tctggaaccg gtgagtatgt acagctcttt gaaccgcagg cttctctctt tgagaaaaaa 2541841 ggcatcggcc atatcgtggc ttcattcgga gaagaatcag gagaggttcc ttatacgact 2541901 tttatggcga aacaaagcta tttgaagaaa aatgaagaca cagccgtcaa gtttacaaaa 2541961 gccatttata aggcgcagca gtgggttgaa aatcattctg cgaaggacat cacagatgcc 2542021 attaaagatg aatttgatga taccgaccca gacgtcatcg aaacatccat tgaacgctat 2542081 aaaaaacagc attcatattc accagaccct ctgcttaacg aaaaagaatg ggagcttctc 2542141 caaaccatta tggataaatc gggagaactg ccgaagcaca ttccatacaa tcagcttgta 2542201 aataaagaaa ttgctgaaaa agtcacctcg gagaaatagg aggcgccatc tatgtctttc 2542261 ttacatgtcg accatgtaac ccatacttat ttttctatta aagaaaaaac aacggctgtg 2542321 cgggatattc atttcgatgc cgaaaaaggc gatttcatct catttctcgg cccaagcggc 2542381 tgcggaaaaa caacattgct ttccattatt gccggtttga ttgagccatc agaaggcaga 2542441 gttctgattg aaggccgtga gccgaatcaa aaagaacata atattggcta tatgcttcag 2542501 caggattact tatttccctg gaaatctatc gaggaaaatg tgcttctcgg tttaaaaatc 2542561 gccgacacgc tgacagaaga aagcaaagcc gctgcactcg gtctattgcc ggagttcggc 2542621 ctcatagatg tggagaaaaa atatccgaaa gaactgtcag gcgggatgcg ccagcgggct 2542681 gcgcttgcaa gaacacttgc gcctaaccct agtctgcttt tgctggatga gccattttcc 2542741 gcgcttgatt ttcagacaaa gctgtctttg gaaaacctgg tattccgcac attaaaggaa 2542801 tatcaaaaaa cagcagtgct tgtcactcat gatatagggg aagcgatagc gatgagcgat 2542861 acgatctttt tattttcaaa tcagccgggc accatccatc agatttttac cattcctaag 2542921 gaattggccg cgatgttgcc ttttgacgcc cgtcaggaac cttccttcca gacactgttt 2542981 caaacgatat ggaaggagct gaattctctt gagaaacagc aaagaaacca ttgatctgct 2543041 tcacgagcag tatcaattca aacagaaaaa ggaaaagtgg aaggtccatt cctttcagct 2543101 tgccatattt attctctttt tctcgggctg ggaaatctcc agcaggcagg gctggatcga 2543161 tccgctgatc ttcagctctc catcagctgt gtggcgatta ttgctggaga aacttggtga 2543221 cggttcttta ctgtcacaca tcggcgtcac tttatttgaa acggtgcttg gctttttgct 2543281 cgggacgttt atgggcacgt gcctagccgc tttgttatgg tggtctaacc gacttgccag 2543341 aattttagat ccgtatcttg tgattttgaa cgcaatgccg aaagtggccc tgggcccgat 2543401 cctgattgtc gcgctcggtc ccagttttat cagcatcatt gcgatgggag ccatcatcag 2543461 cgtcattatc acaaccatcg ttgtctacac cgccttccaa gaggtcgacg aaaactatac 2543521 gaaagtcatg aaaacattcg gcgcaaaaaa gtgggttatt tttaaagaag tcatactgcc 2543581 tgcatcctcc cccgcgatta tttcaacact aaaagtgaac gtcggtttat catgggttgg 2543641 cgttattgta ggggaattcc tcgtttcgaa ggtcggatta ggatatatga ttatttacgg 2543701 attccaagtc ttcaatttta cactcgtctt cttaagcctg ctgatcatcg ccatcttcgc 2543761 cactctgatg tatcagggcg tcgagctgct ggaaaagaaa tggacgaagg ggaggacata 2543821 aaaaacccgg cacatgtgcc gggtttttta ttcaatccat ccagattctt tcagtttttt 2543881 caagctgatc ggaagaacgg aatccttcat aataaagctg aattttttat tgcgggaaag 2543941 gttctccggc agctcgtgaa acaaaaccgg gcctttcgtt tcaaagtaat cagcctgctt 2544001 ttcaagcttt tctatatctg caaaatatat attttttaca atcacttttt cttttccgag 2544061 aactttatac tgtccgagat acttgaggct tttgactctc gcgcccgtct cttcctttac 2544121 ttcccggagc gcagcctctt ctgcgcactc catcggctct actttcccgc ctggaaactc 2544181 atagcctctg tcctcatgtt ctgttaaaag ccatttgccg ccaaaacggc aaatcaccca 2544241 gacatgcttc gggctgtccg agaaaggctg atcgtcaaag gaaagctgaa cagtattctg 2544301 ataataatct ttaaactcgt acatgtttat ccctcaaatc cgttcctagc tatcttccat 2544361 acatcatacc acagttacgt ttcttcggaa gccttttatc aaaaaataag ggaaacccag 2544421 cacgccgtca ggttctgcat gcagactagc tcgtacagtt tttttgcgat acttttgccg 2544481 gaaagtgcga ccgacgctct gggctttatt atgacccgcg aacagggaaa agttacggtt 2544541 tgcgcttaaa tttatttttt aacgtttcta aaagatcgac aagcatctga ggaaccggta 2544601 tgccaagaga gctggctgtc acaacaattt gcacagattc ataaagaata taaaacataa 2544661 tagccaagtc acgaattgat ccctgtgtat tcagcagctg atcaaaaaag tggcatacag 2544721 agatcagagc cagcgtgact aattttttga caagccgggc aaataccttt ttaaatgaca 2544781 gtttgtgaat aatggtttcc ttcaaagtcg tactgataaa ttcaattgcc ataagagaga 2544841 gcaaaatcag aaatgaatac tgaaaacctc caaagaaaaa acccgctgct gaaacgctga 2544901 ctgctaaaaa cgaaaagatg ccaaagtctc tatccattta tcccaacatc ctttcacaga 2544961 aacggcctta cgatattcta tggtaaacaa gccgaacgga ttggattttt cagaaaaatg 2545021 gactggttgt cgcctatttt tcagatacaa aaagaaaagc cggacgtctt ttttaagaca 2545081 tccggccgtt ctatttttga acttaaccta ggtaagcttt tagcatccag ttatgttttt 2545141 caatattttg atggatcgca agaagcatgt cccctgttgt ttcgtcaccg acttcatcag 2545201 ctaaatccat gccgtttttc agctcttccg cgatgactgt gaaatcatca tatacgcttt 2545261 gaaccatttg ttcagctgtt tcatttccag cagcttcttt gacagaagcc gtttctaagg 2545321 attccttcat tgttgcaatc ggttttccgt tcagcgccaa aagacgttct gctaagtcat 2545381 caatataagt tgctgtttcg ttgtacagct cctcaaactt ttcatgaaga gtgaagaaat 2545441 ctttcccttt cacataccag tgataattat gtagtttcac atacatgacc gtccagttgg 2545501 ctacttgttt gttcactgct tgaatcaatt gttctgacat ggtatctcct ccttgttata 2545561 tgactatgta tacccttaat atcgtacgct aaaacctctt ttttaccctt atctgtcacg 2545621 atttcttcta ttatgctaca attgttaaaa aacgggaggt ggaatgtcat gacgcttctc 2545681 attacgataa gtattttgat tgtgctggct gttttgcttg taaccatttg gacgactgta 2545741 aaagcctata atgtaaagca taccattgat ccaccacaag aaaatcactc tgattcacac 2545801 aatcaatgat gatgtgaatg ctcctcttct gactgattgc tggcagcatc ggcgtctccg 2545861 acttggactt ttaaggtcgg catgctatgc tgtttttttg ctgtgacatg agattggaca 2545921 gtgtatacac catcttcctt aaacgtcgtt tccaatcggt atacgccttt ttcttgtttc 2545981 accttaaaca tttggcttgc gtctttttcc ccttctttcc atacttcaaa ctctacttca 2546041 tcggcatccg tcacagcttc atcaccatat gatacagctg cttcataagc agcgctttct 2546101 ccgggattta ctttttcagg cccggtcagc ttgacatcca aaacctcggg cgtctcagct 2546161 gtatttgctt tactttcacc agatccgcat ccattaagca ataaagcaga aaaaagcaga 2546221 acaaccaaca tctttttcat gccatcaccc tttcatcgtt tacctaaata gtagcaaacg 2546281 cttacagcaa atggtacaca aaatatgaga cgtcacaaaa aagacctttt tgcttaagcg 2546341 caaaaaggtc ctttctattt tagccaaata cttttagcaa ttcttcttta tcctgtgaaa 2546401 gccagaaacg cattaaacgt ttagcgcctt ccagatcatg aagcttcgct tggccgcact 2546461 gcttttcatt cgcagcaggt atttctgtaa tctctaccgc ttccttcatt gtgtcttcaa 2546521 gcagatcaac gatttccgct gatgtcggct ctccgctcac aactagataa tagcctgtct 2546581 ggcagcccat tggagaaata tcaatgatat caaaatgatc gtatttctca gcgtgagaac 2546641 gaatcgtaaa cgcgagcaaa tgctcgagtg tgtgaatggt gtcaggcttc atcgcctgtt 2546701 tatttggctg gcaaaaacga atgtcaaatt tatttacaac gccgtctgtt cccactttat 2546761 gcacgccgca atgtcttaca tatggagcaa caaccgcatt atgatcaagc tcaaaacttt 2546821 ctactgaagg cataatggca ctctcccctt ttttaaaaat gtaatttcat tataacatac 2546881 ttttccgata agaattattg attaactttt caatctgtgt tttttttctt atacttgcat 2546941 cagaaaggtt gctgaagaaa catgaaaacc ctattcatcg ctctgatcag aggatatcaa 2547001 aaattcatct cgcccctgac accgccaacg tgccgctttt atccgacctg ttcccaatat 2547061 ggaatcgaag cgattaaaac acatggcgct ttaaaaggcg gatggctgac aatcaaacgg 2547121 attttgaaat gccacccgtt ccatccggga ggagtcgatc ccgttcctga aaagaaacaa 2547181 aaacattaat tgttataacc gtttacgata agatccagtt ttccggtttt aggatcaatg 2547241 actaagccat ggaccggaac gttttcaggg aacagcgggt gatgtttaat aacatctacg 2547301 ctgtctttca cactcgcttc cactgaatca aagcttttaa accattgatc aaagtctaca 2547361 ccggagtact ttattgtttc gatgcgttct tccggaatcc ctcttgcttt gattttttca 2547421 agcatgcttt tgctgctgat tttgctcatg ccgcaatcgt gatgcccgat cacacacacc 2547481 tcatctgcat tcagctcgta cactgcgacg agtatacttc tcatgatgct tccgaatggg 2547541 tgtgtcacaa gcgcaccggc acttttaatg attttcacat caccgtttcg caaattcatc 2547601 gcatgcggca gcagttcaac cagacgagta tccatgcaag aaagaatcgc cattttttta 2547661 tctggaaatt ttgatgtttg atacttttca tactctcttt gttcagtaaa tgtcttgtta 2547721 aattcgagaa tatcatttag aagactcatg ttcgttgtcc ctttctattc tttttactct 2547781 tcaatatatc acaacccttg tttattcgtc ataataaaaa aagacaaacc ctcaggcctg 2547841 ccttatttcc ccatgttata gcgttttttg aactgctcaa ctcgtccgcc tttttcattg 2547901 aatttctggc ggcctgtata aaacggatgc gtgtcagagc ttacctctac tttaatgaca 2547961 ggatatgtgt ttccgtcctc ccactctgct gtttcattag atgttttcgt agaggtgctt 2548021 agaaaacggt agccgctgtt gacatcctga aatatcactt tgtggttctt tggatgaatt 2548081 ccttctttca tgggtatctc ctttcaataa atcgtaataa ttacgtttta ttttataacc 2548141 ttacaaacgt tttgtcaatc ttcttatatc cttccctctg tttcacatcg taaacctcat 2548201 ggcatttaag aataggaaga ataatctaac cgaggaagca aataataaac ccaaaataca 2548261 tacagaacgt ctttttggaa aggtggttta cgattgtgga tgatttagtt ttggccagaa 2548321 gcctttttgg cacgacgatg ggctttcata tcattttcgc aacacttgga gtcggtctgc 2548381 cgctcatgat tttagtggcg gaattgatct atcaaaaaac gaaagatgac cattatgcga 2548441 tcatggcgaa aagatggacg aaagcacaag ccgttttgct gggggtcgcc ataccgaccg 2548501 gaacgatcgc gggcactcag ctcgcgcttt tatggccggg atttatggaa gtcatcggcc 2548561 gggtgatgtc cctgccattt caaattgaaa tctatgcttt ttttgttgaa gccctattca 2548621 tgtcgattta tgtatacgct gcagaccgtt tgtcacctgc aatgaggatt gttgctgttt 2548681 tctttgtgtt agtcggggca gcagcatccg ctgttctgat cacgaatgtt cacgcttttg 2548741 aaggtacgcc cgccggtttt aaaattttaa acggaaaaat tacagatgtt gacccgtggg 2548801 ctgcgttttt taatcctagc ttttttatca ctgccggcca tgtcgtgctg tccgcgttta 2548861 tgactggtgc gtttatcgtg gcttctgttg cggcgtataa aatgatccga acgaggaaaa 2548921 aggaaagggt ctatcgcttt caccggaaag cccttttgct cgcactgacg atcggcggta 2548981 ttttttcatt gctgaccgct ttgaacggac acgaatctgc acagatgctg tacgaatacc 2549041 agcccgaaaa attagccggt gcggaaggcc tatttgaaac aagatcccac gccccgctcg 2549101 ctatcggcgg ttttaccgac ccgaatgaag aaaaagtaaa atgggcaatc gagattccat 2549161 gggctttaag ctttttggca gcgaaccgtt ttgacactgt tgtaaaagga ttaaatgcat 2549221 ttccgagaga tgaatggccg ccgcttttca ttcacacgct gtttaatgcg atggttggtg 2549281 taggcatgct gctaattctt tattccatta tcggtgtggt ctggagaaag gtgctcaaga 2549341 aagaccgttt cccaacgtgg cttttgatca ttttcatgac agcaggccct tttagtctca 2549401 tcggcattga attcggctgg attttcgcat gtacggggag gcagccttgg gtcatctatc 2549461 atctgctgaa aacgtcagat gtcgtaacaa cgactggctc gatcggggtg ctgttcttat 2549521 ttttcacatt tgtttatgcc gtgttaggcg cagctgtcgt ctacgtgctg ctgtattatt 2549581 tccgcaagca cccggttgac gaagatttaa atacagcgga gtcgtaatgg ctccgcaaac 2549641 aggaaaccaa atggaaggaa gatcgtacaa atggagattt caactgacgc tctgatcgcc 2549701 atctcaatta tctggggctt tgtgtttatt tacgccgtca tggcgacaat ggattttgga 2549761 gcgggatttt ggtctatgat ctatttaaac aaggagcata tgaaggccac cgatattgcg 2549821 aatcgctttt tgtccccgac ttgggaggtc acaaacgtct ttattgtggc catcgtcgtg 2549881 gcgcttttca gttttttccc cggcgcgaca tttgtgctcg gcaccgtttt attaattccc 2549941 ggaagcatga ttttgctgct tttagcaatt cgaagcggat ttctcgtgtt ttcaaataca 2550001 gcaaaggagc ggaaaacgct aagatatatt tccggcatct ccggctttat cattcctgct 2550061 attttaattt tggtgcttcc tgtgacacac ggagggttta tagaaaaaac ggatggaatc 2550121 tataacttaa atatgtctaa aatcttttca agccccaacg cctattcatt tatcgggttt 2550181 gcgattttaa gcaccttatt tttgtcctcg ctgttgcttg cagatttttc aaatgtggca 2550241 gaggaacagg atgcgtaccg agcctacaga aaaagcgccc tgattaccgg cccgatttca 2550301 ctgttgtttg ctgtatgcat tatggtaact atgcggaatg aagcaaactg gctgtacagc 2550361 ggaatgatga atgatttttc ttggattatt gcatcgttca ttacatttgt cattgctgga 2550421 atcgctcttt ttctgcctaa caaaagcttt ggtcaaaaca tcggaaaacc gcgtctcgca 2550481 cttgttgcga ttgggataca gtattttctc gcaagctacg cgtacgggcg ggcgcatctt 2550541 ccgtatatga tttatcccga tgtgacagtc atgtcaggct tcacagagcc agcaacgttc 2550601 agagcgctgt ttgcaacgta tatcgttgca tttatcattc tatttccggg cttctttttc 2550661 ttctggaaaa tgtttatgcg agataaacgc tatatccgcc aggaggaata gagggcaagc 2550721 cagccggcta tactaatcca gaacctttat aaggagggga tggcatggag cagaaaattc 2550781 tatgtgaggt caacaactgt tcttattggg gcaaaggtaa caaatgcacc gctgatgcca 2550841 tttatgttgt cagccatact ggtgaaacgg ctgaaaacag ccgggaaaca gactgcaaaa 2550901 cgtttaagcc gcatgattta taattaaaag aaagagctgc atcagccagc tctttctttt 2550961 tgcatgttga gtgttctcag ctttttagtt atgaccccgt ttgcaggtga aaacaaaaag 2551021 gcgcttgcat aacatacacc tgtcatggcc gccatcgctc ctgaaatcga aacattaagc 2551081 cacgttgcga agaaatagcc catgaccgcc gacagcccgc caatcaacgc gctgagaatc 2551141 agcatataaa gaagccggtc tgtcagcaaa tgtgccgcag ccggcggaac aatcagcatg 2551201 gccacaacca atacggcacc caccgaatca aaggaagcaa cagtcgtcaa ggacagcatg 2551261 cccatttgca cgtaatgaat gagcaaaacc ggtattccca aggctaaagc catttgagga 2551321 tcaaacgaag cgattttaaa ctccttatag cacacactga tcaacactac gtttaaaacc 2551381 agaacagatg ccagcatcca aaacgctttc ggcccaatat caaccccgaa taccgtcacc 2551441 gtattccacg gcacaaaagc gatttctccc attaacgagt gctcaatatc gagatggaca 2551501 ttcgctccat acacagaaag caaaataacc ccgattgcaa ataaggatgt aaacacaact 2551561 cctatggcag catctgattg aacccccttg ctatgaagaa gctgaaccaa gaaagccgtt 2551621 aacagaccgg ttgcggctgc gccaataaac atataaatcc catcgagact tcccgtcact 2551681 agaaaagcgc cgacaatgcc aagcaacact gtgtgactga ttgcgtcggc cagcatcgcc 2551741 atgcttctca gcacaagaaa tgtgccgatc aatccgcagc ttacaccgac taatacaccg 2551801 gtagctataa tccatgcttc aaaactcatt tgcgatctgt cccttctcgg catcatgaga 2551861 cgcttttcga cgctcaggca tccgtccata cagctttaag agtgaataaa gccgctctct 2551921 cgtttctctc ggtaaacggt ccgggtcaaa gtagtcctga tcggattcta tattggcaag 2551981 ttccatttca tgcatgagat acacttcata catccgctgc ttcaaagctg tgtgatagcc 2552041 tttttctatc cctttgcttg tgatttgcca aatcccattt tcgatacgct caatgcacct 2552101 ctcttgttcc aagtcattta atgccttaag gcataatgaa ggggataggc gtcttttctt 2552161 tcttacactt tcaacagtta cacaaagatt attcttttca tactgttcat aaatcgccaa 2552221 aagcacttgc tccctgcttg ttctgcgccg cagcctcatc agccttatgg ctttagcagc 2552281 caatccccgc ttaggcgcgc aaatcattga aaaaagaaag agcagcgttg cagataagat 2552341 cattaatggc cctgtcgcca ttcccttcat cgtggtgcta agcagggttc cggccactcc 2552401 gctgaccccg cctgtaatcc cggcaatgat gatcatcccg gttaatcgtt cggtccaata 2552461 tctcgcggtt atggcaggtg taatcagcat agccgccatt aatatcacac caacagtctg 2552521 aagcccaatg acgacagcac agacaatcag acaagccaaa agcccgttta aaaaacgcac 2552581 cgggattcct aatccctttg caaacgcgag atcaaaagta atcaatgtaa attccttaaa 2552641 gaaaacaata cataggagca gtagaacagc ggatatccct gcaataagga tgatatcctg 2552701 cctgaccaat gaagcagcct ggccgaataa aaaagaatca agcccgcttt ggcttcccgc 2552761 cccctgttgc tgaatatatg tcagcagaat gatcccgacg ccaaaaaaca cagaaagaac 2552821 aatcccgatc gccgagtcct cctttgtttt tgaaagccga ggaatcagct gaatacaaaa 2552881 cgttccgagc agtccggcga gcgctgcccc cagcaaaaag aaaggcagtg atttttgccc 2552941 ggtgaacaga aaagcgagac acactcccgg cagagctgaa tgggccatcg catcgccgat 2553001 taaactttgc tttctcagca gcacaaagct gcccaaaaca ccgcttgccg tcccgagcaa 2553061 aagcgtaccg gccagcaccc actgtgtatt cggatgctga agctgcagcc acaaactttc 2553121 aaacattgcg ctcactcctt atgtccttct gccagcactt tatcttttaa aaacgtaagc 2553181 cttcctccat atgttttttg caggttttcg atcgtaaaaa cgttttccgt cggtccgaaa 2553241 gcgattttcc ttaaatgaag cagtaagatc caatcgaaat aatcctcggc ggtctgcaga 2553301 tcatgatgga cgacaagcac ggtttttcct ttttctttga gttctgccaa cagcgtcata 2553361 atcgcgcgct ccgtcgctgc atcaacacct gcaaacggtt catccataaa ataaatgtca 2553421 gcgttctggc agagtgcccg ggcaagaaac acccgctgct gctgtccgcc tgacagctgg 2553481 ctgatttgcc ttttcgcata atcatgcatc ccgacttttg ttaatgcggc cttcgccatc 2553541 tccacatccg ctttctttgg cctctttaat aaaccgattc tcccgtatct tcccattagg 2553601 acgacatcga gcgggcttgt ggggaaatcc cagtcaaccg agccgcgctg cggaacatat 2553661 ccgattctgg tccgctgatc cttatagtct ttgccgtaaa tagagatgtc tccggaagct 2553721 ctgggcacaa gaccgagaat cgttttgatc aaggttgatt ttcccgcgcc gtttgggccg 2553781 ataatgccaa taagttttcc ttcaggcacc tgcagcgaaa tgtcctgcag tacaggcttt 2553841 ttatgataag caaccgtcac attatcaagc tcaacaggga acatatcctc cacctctttt 2553901 ctttatttaa gcgctttagt aatcgtgttg atattgtggc ggaacattcc ttcgtatgtg 2553961 ccttcttttg tgcccttttc acccatggca tccgaataaa gctgaccgcc gattgtgact 2554021 gtatggcctt tttctttagc gccttccacc actgcattga ttgatttttc agatacactg 2554081 ctttctacga acacagcttt tatttgtttt tctgtcagaa gatcaaccag ctcctgaaca 2554141 tcccttaatc catagtccga atctgtgctg agtccctgca ggccttttac cttaaatcca 2554201 tactcattcc caaagtacgc aaacgcatca tgagcagtca caagcacacg gcttttctcc 2554261 ggaatatgtg cgatctcctt acgcgaccac ttatctaaat attgcaaatc ttctttgtac 2554321 tctttggcat ttttccgaaa ggcatctgcg tgctgaggca ttgctttgct gaattgcgct 2554381 tcaatttcat ccaccgcata gatccataac ggaatgctga accagacgtg gggatcaaac 2554441 gtcttgcctt cccccgcggg aataagctta tttttcggaa tggcctcagc tactgccgcc 2554501 gattgttttt gttcgccgat tttttggagg acatcctcca ttttcccttc caaatgcaac 2554561 ccgctgtaca gaacaacatc ggcagacatt aattttttcg tgtcaccttg ggaagctttg 2554621 taaaggtgcg gatcaacccc cggtcccatt aaagaggtga cttttacgtg cttacctccg 2554681 atgttttctg ctgcatcggc aatttgagat gttgtcgctg tcacttgtaa ttgctgatca 2554741 gcgctttttc cggctgaatc cgttccgcat cccgttaaag caaaggtcgc aaaaagtact 2554801 gctgccatca gcccttgtct catatttctc ctcctctttg ccatcaatgt ccgattgttt 2554861 tatcttatgt tgtcagttct tagacatgtg acattaaatt agccaaaagc atgttttatt 2554921 tacacaggac aaaaagtttc cctcatgcaa aattatcgcg tttggccatt tttgtcaagc 2554981 tgatttacat aaaaaaaccg gctgggtcag cagccggtcc aaacgagaag ggatgtattc 2555041 aacgaacact tttactgtaa cagcacagtg tcatttattc aaaatagcaa aatgcttttt 2555101 tcttaaccat gctgtgtgaa aacatccatt ttggtcacat attttcgcat aatatcttgg 2555161 tttacctcaa cccctaaacc aggctgtttt gacacagaaa taaatccatt atcaatacga 2555221 atatcaggag ttacaatatc ttcatcccaa tagcgtgagg atgaagatat atcgccaggt 2555281 attgtgaatt gaggcagtga agcaagcgcc acgttctgcg ctcttgatat gcctgtttcc 2555341 agcattcctc cgcaccaaac ctgcatatga tgctctttgc ataaatcatg aatttttaag 2555401 gcttctgtta agccgccgac acgagaaggt tttatattaa taattttgca gcttcctagc 2555461 tcaatcgccc gtctcgcatc atcaactgaa caaatgctct catcaaggca aatggccgtt 2555521 ttcaaatgtt tctgcaagtg gcggtggtca acgatatcgt cagcttggag cggctgctca 2555581 atcatcatta aatgatagtc atcaagctcc tttaaacggc tgatatcctt cagttcgtaa 2555641 gaggaattgg catcggccat aagcgggatg gttgggaatc ggctgcggat ggccttgacc 2555701 aattccacat cctgcccagg ctgaatttta atttttattc tttgataacc ttctttttga 2555761 tagctctcaa tttccttcag catatcgtca agaggcgcca ggccgactac caccccggca 2555821 gggactttat ctcttgttcc gcccaatgcc tcagcaaggg atacgccctt ctttttggca 2555881 taaatatccc atacagccga ttcaagtccc gcttttgcca tccggtttcc tttataccgc 2555941 gccaggctgt ccggcacttc tgaagggtga ttgaattcac ggccgacgac atttgggata 2556001 aaaaaatctt ttagcatatg caaacatgtt ccaatggttt cctcggtgta ccaaggcgaa 2556061 gagaaagcgg aaacttctcc ccagcctgtg acacctgatg tatcaatggc ttccacgatc 2556121 agaaatttac gctcttgaag cgtttcgata ctgtttttaa acggtttctt taagttcatg 2556181 ctcaaatggt aaagcgtgat tttttctatt tcgatcatag cagttctcct ttacgcgcat 2556241 ccttcagctg atttcgcaag agcttattag acgcattgcg cggcaggcgg tcaagcacaa 2556301 agaattttgc cggaatttta tacttcgcca agcgttcttt gcagtagtca gtcaattctc 2556361 ctgcgctcac aggcttgtga aggacaagat aggcgtgagg cactttcccc cattttttgt 2556421 cctcagcccc tgaaaccccg gcttcggcca cagcggggtg tgaaagcagc actgactcca 2556481 cttcggccgg ataaatgttt tctccgccgg atatgatcag atctgaacgt ctgtctaata 2556541 catataaaaa gccttcattg tccaaataac caagatcacc tgttttcagc cagccatttt 2556601 gaaaggaggc ttcgtttgcg ctctcccggt taaaatagct tttcatgaca ttcgggcctt 2556661 tgaccatgat ttcaccgtgt tcatacggtt cacatacctg tccgtcccgc tctattttga 2556721 tttcacacga aaacagcggt ttccccgcag atccgagctt ttccatgctg aattccggcg 2556781 acagggtaac aatttgcgag catgtttctg tcattccata tgactgaaag acagggaatc 2556841 ctttctcacg gcattcctca agcaatggca gcggtgcagg accgccgccg agaagaatgc 2556901 atctgatgga ttcagggcag cggtttgttt cttccaaaag actggccagc atagtctgca 2556961 ccgcagatat cattgtcact tcatgcctgt tgatagaatg cagcacatcg cttacggaaa 2557021 aacgctggtg aagcacgaca gtcattccat agatcacaga tttaaataat gcggacaatc 2557081 cgctgatatg aaagagcggc aatgcgataa gccagcggtc ttgttctgtt atacccaaat 2557141 taagagcgga cgacaccgca ctgaaataat ggtttccgaa cgtttgctga actcccttgg 2557201 gctttcctgt cgtacccgac gtatacatca gcgttgccgt tgcatccatt tgcatataag 2557261 cctcgatctc aatttcctct gctgcttctt tcatcagttc atccacatca atcgtttgaa 2557321 cgatgtgttc atattctttc ttctcaaagc ttgaatctgt caataaaaag ccggatcccg 2557381 aatcctccag ctgaaacagc ctttcatgtg ttgacagctt cgtattcaaa agcaccgcct 2557441 taacaccaag caaaaaacaa gcgtgaacag cgtataccat ttctgcacgg ttttggagca 2557501 aaatagctgc agtatcccct ttccgaaccg aatgagcggc aagctgttcc gccattcgtt 2557561 tagacgcggc aaacaattct gcaaatgtca cggtttggtc ttcatagatg agagcgattc 2557621 tctcaggtgt cagctgtgcc cgctgcatga gccagttggg ctgttctgtc agcatgtcat 2557681 catctccgag gtaaaatgtc tgtattgaaa agaaaacagc ttggaccgca aagtctcaag 2557741 ctgttggttt actagatatt gctgatcacg gaaaacgagg gaactgtccg aaatcaggtt 2557801 tgcgtttttc cttaaaggaa tcacggcctt cttttgcttc atctgttgtg tagtaaagaa 2557861 gggtagcatc ccctgcaaac tgctgaattc cagcaagtcc gtctgtgtcc gcgttaaacg 2557921 cagctttaag aaagcgcagt gcggtcgggc ttttttcaag catttcttca caccatttaa 2557981 tcgtttcttc ttcaagctgt tccaaaggaa cgactgtgtt gacaagaccc atgtccagtg 2558041 cttcctgtgc gttgtactga cggcataggt accagatttc acgtgctttt ttatgtccta 2558101 caattcgagc caggtagcca gaaccgtaac ctgcatcgaa gcttcccact ttagggcctg 2558161 tttgtccaaa aattgcgttg tccgcagcaa ttgtcaagtc acatacgatg tgaagcacat 2558221 ggcctccgcc gatcgcatat ccggacacca tcgcaacaac cggtttcggg atgacgcgga 2558281 ttaaacgctg aagatccaat acgttaagac gagggatctg gtcgtctcct acatatccac 2558341 cgtggccgcg cactttttgg tctccgccag aacaaaatgc tttgtcccct gcaccggcaa 2558401 gcacgataac cccaacgttt tggtcgtctc ttgcgtcagc aaacgcatca atcatttcag 2558461 caaccgtttt aggggtaaac gcattatgta cctcaggtcg gttgattgtt atttttgcaa 2558521 tgccattata cgtttcatac aatatctcat cgtatgtccg ttttgttttc cattcagcca 2558581 tatgatgacc tccttttatt ctctatgtga atgagtcaga tgcttgtcaa aaactcactc 2558641 actattttac caaacaatcg cggctgctcc acatggaccg tatgtcctgc ttttggaaca 2558701 atctctattc tactagaagg aagcatctta tgcacctctt gattgatggc gcaaaatttt 2558761 tcgtcccact ccccgcagat cagaagcaca ggaacatcta tttcctctac acggctccac 2558821 aaggaaggct gtgaaccggt gcccatgccg gttaaactgt tcgcaagccc aatcttattg 2558881 ttccgcagac ggcccgatcg tatcctgtac cgaatatctt cagccagcct ctgctgagat 2558941 gaaaacaaag ggatattctc ccaatacgca acaaacgctt cgagcccgtc tcgtaaaata 2559001 aaatcagcaa gcttccggtc ccgcatgatt cgttcccgcc gttccccaag tgttttgagc 2559061 cccggcgtcg tgctttcaag cacaagtgcc gatacccgct cgggatatgt catcgcaaaa 2559121 gagtaagcaa gccttcctcc catagaatac ccaatcaatt tcactttgtg aagttttaat 2559181 tgatcaaaaa tctcggcaag gtcagaaact tgccgggttg tgctgtatct tttcccattc 2559241 agcggggcat cggtttcccc atgccctaaa caatcaattt tgatcaaacg ggaatcaggc 2559301 agcatttcat caagaaaagt ccatgattgt ttgctgccgg taaacccatg cagacagacg 2559361 acggcttcgg aagcattcgg tccctcgtct gccactgcat atcggacacc atctgatacc 2559421 gttatgttta cagttcccat tgttttttca cttcccgcac agcctcattc agcatatcgc 2559481 gatgaagctg gactcttgat tggcgatccg ttttgatttc aatcaaatgg agtccgggct 2559541 tgtctgcctg cggcgcgtaa gctgttttga attcatccca agaagccggg catgaatacg 2559601 ttccgccgta aagtgcagcc gcatgcttga aatcgagccc tgtcggtgtg ccgaacaaat 2559661 cttcaaagtg tgtcttctca gaagcctgcg gcaaaaagga gaaaatccct cctccgtcat 2559721 tattgacaag aatcacagta agaggaatac ccagcttttt ggccgccagc aggccgttta 2559781 aatcatgata aaaagataaa tctccaatca caagggtaac aggcgctttt gttccttcac 2559841 atacccccat ggcagaggag acgacaccgt ctatcccgtt tgctccccgg tttgaataaa 2559901 tccggaaagg gcggtcctgc ttttcaaaaa acgtatcaac atccctgatc ggcatgctgt 2559961 ttcccacaaa cagcgagctg ttttcaggca caagatgctg aaggattcga tagagattgc 2560021 cttcaaacga aacatcttca ctgctgattg tttgcagatg ctcgcggaac cgcccattga 2560081 caaactgcca cttttccagc cactctgagg atctggtggc agcagtaagg cctgccatga 2560141 tctcctcagc aaaaacagac gcattacaat gaatcatatg cgcgcttgcc tgtgtcgggt 2560201 ctctccaccc tccatcctcg tcaatcacga tttgctgaat cgtcggatca tccttaagcc 2560261 ataagaaaac cggttttgaa acaggcatcg gtccaaaccg aatgacaaca tcaggacgga 2560321 gtttccgctt cagctcatca tcttttaaaa acgaatcata cgcatcaata acagtgcttt 2560381 tatcatgaac accattccgc agattagaca gcggatctgc taaaattgga tactgaagcg 2560441 cttttgacag cgcaataatg ttttccttgt ccgcatcact atggagctct ccgcagacga 2560501 tcattccttt ttcagcctct gcgagcatct cagccacatc agacagggac tctcggtcaa 2560561 cagactgcgt acccgttttc acagacacat gacggcctgt tctcattctt ccaaacggct 2560621 catctgaaag atccggcatc agcggttcgc gcagcggcac attcacatgg acaggcccca 2560681 tcgggcgctt ttgtgcttct ccggcagcgc ggcttgccag cgttcggatg tatctcagca 2560741 tttgcggaga ctcttcagga agagcagagt ctgtgaaaaa cttaacaaag ttaccgaata 2560801 agaagtgctg attaatagcc tgcggtgcgc ctacttcgcg cagctcatga ggccgatcag 2560861 cagttaacac aataataggc acccttgaat aatgggcttc aaccacagcc ggataaaagt 2560921 tggccgcggc tgttccagat gtacagatca atagtacggg acgctgcttc gcttttgcca 2560981 aacctaatgc aaaaaatccg gcagaccttt catcaatttg gacatggacg ctgatatcgg 2561041 gatgcgcagc acaaagaaca gccagcggtg tagatcttga gcccggacaa acgacggcgt 2561101 ccgtaattcc ggaaagggcg aattcatcaa taaaacttcc gatgtaatga gtaatcgggt 2561161 tgactgtcaa cgcctctcac ctcctaatgc agagatcatc ggcttcaatt taatctgtgt 2561221 ttcttcatat tccgagattg gttccgagtc ttccacaata ccgcacccgg caaacagcct 2561281 tgctgtgctt ccttcgatga gccctgaacg aatggcgacc gcgaattccc cgttatcctg 2561341 gctgtcaatc cagccgatag gggccgcata ccagccgcgg gacatcggtt caatctccct 2561401 gatcacgtca acagcttttt cctgaggtga tcccccaagc gcgggagtgg ggtgcagctt 2561461 ctcaattaag tcaaaaatcg aagcagactc gcgcagctgt ccgacaatcg gcgtaaacag 2561521 gtgctgaacg ctttttgttt tgtacaaaac aggtccatca ggcttttcaa cctctgaaca 2561581 gcttgataca aaagcattat gaatcatacc taccacaata tcatgctcaa gcaggttttt 2561641 ctcatcgttt aataattcaa ggcctatccg gcggtcgtct tcttcattca cgcctcgttt 2561701 aatggagcct gccagacagg aagacatgac agtgccgccg tctcttttga tcagtctttc 2561761 cggagacgcg ccgacaaagg ttttgccttc ttgttcaatt gcaaaaacat agcttgtctg 2561821 ctgatcgtcc agaagcgttt taagcaccgg ttcaatttgg attggaccgt caaacgtgag 2561881 cagcagctct cgggcaagaa caaccttatc atattgtttc tctttaattt ggcttgtggc 2561941 cgtttcgatt gctttcagcc aatcatcctt atccagctct tcggctgctg caatcacagc 2562001 ctgatcttct tgcttgaaat cgggaaccat aaattccgcc gcaaaagctt ttaagccttc 2562061 taaaacagct tctgcgtctt ctcctccgct tacccatctg ttaactgtta agaacgggcc 2562121 ttcagcagtc atcgtcagca taagcgcagg cacaaagaaa tccccttccg agaaatggtc 2562181 ccattgtgaa cctctttctt cgcaagggtc aaaagaaaat cctccgaata acacaggtcc 2562241 cactgcagaa tgctgcagct tttcttcttc ataaatatga aaagccgtct ttttaaagcg 2562301 ctcccattgt tcaaaaacct cacgataccg ctcgctgttt ttttgatttg tctggaaaac 2562361 cgcttctttg ccaagaccga ctattgtcaa ttcactttca ggatctgacc aaaaaaatcg 2562421 attgcctgta tatttttttg ctccgtaatt gaaaaatgat agagggtcaa gagactcgat 2562481 ttgtctcgaa tagcttatta agacagcatg gttgacttct ttggctttat gtaatgcatg 2562541 tagaacttcc tttcggaacg tacgctgcac cgttgtcacc atgagacatt cctccataat 2562601 ccttaaaatg cttttaatac catacacctg tgtctccttt gtgtcaaaca cagatcatgc 2562661 agtccaaatg gcctgcctta cctattataa acctaatttc agaaatgaaa aagaaacaaa 2562721 gcttaaattt ctttctccac tgatagcaaa ggttgtatcc gcttaccata aaaggaaaac 2562781 ctcctatatt cctccacccg ccatttatga aagttctcag gcgatctgtt catactaaag 2562841 gtatgcatca cagagaaacg aggcgatcac attgcttacg aaagaacagc ttcagcattt 2562901 aaaaaatgaa ctggaacaaa cgaaaaaaga tatcttaaac cgtttcaaag acaatgatca 2562961 ttttcagctt aactcagcct ttccttatga ttcgtggggt gagctttcgg catacgacaa 2563021 ccatcccggc gatcaggcga cagaacttta cgagcgtgag aaagacatcg ctctagactt 2563081 gcatgagaga gagcaccttc gggacattga gcattcattg aaggcgatag aaaacggtac 2563141 gtatggcatt tgtgaagtca gcggaaagga aatccctttc gaacgacttg aagcgcttcc 2563201 gactgccaca accctcgcgg agtattcgtc acaggacgtg gtttccaaag accgtccgat 2563261 tgaagaagaa acaccattcg ggcaatttga atttgatgat gatgaagaaa tcagagcgcc 2563321 atatgacagt gaggattcct atcaggatgt cgaaaaatat gggaactcac aaacgccgca 2563381 ggatatggaa aaccctccgc tcagctatga tgatatgacg atgaatgccg aagagaatat 2563441 cggcaatacg gagtcttacg aaaatttcat cgctacagat atcactggga aagaaattac 2563501 cgtttatcaa agcagagccc atgagcgcta tgaagaagaa cttgacgaag agggaatcat 2563561 gaccacattc ggcgatctcc acgctgattg aacccccaat tattgggggt tcttttccgt 2563621 tttcagcata tcgtaaatca gcttcagata atccttttgc aggccgatgt cataccgctc 2563681 gccctctagc aatttcccgt atacggtaca tgccccgagc gaagctttta tcgcatccgt 2563741 tacctgcact tctcctccgc tatcagcttc taatgcctcc agctcattaa aaatatccgg 2563801 tgtgaaaata taacgccctg ctgcggcaaa atgagacgga gggttttgtt taggcttttc 2563861 cacaatatcc tgtatgcgat aaagcccttt ttcaacaggc tcccctttta tcaccccgta 2563921 atgatgtaaa tcctccgttt ttgtttcttt taagccgatc acactggact gatatttcgt 2563981 atacgcttca atcagctgcc ccaaagccgg ctgattggcg gaaaaaatca gatcatctgg 2564041 caaaacgacg gcaaaaggct ctcctcctgc aaattgcttt ccgaaagaaa tggcgtcgcc 2564101 aagacccttt gcataaggct gccgcacata gtgaatccgt atatccggaa tgggatgctc 2564161 tctaagtaaa tgcagtttat tcttagaggc caaaaaagcc tcaagtgcca aagaggaatc 2564221 aaaatagtcg acaatcagat ttttatggct cgatacaacc atcaaaatgt cctcaatgcc 2564281 tgactccttt aattcttcaa caagataatg aatcacaggc ttagatccta ccggaaacat 2564341 ttctttcgga atcaccttcg tcaccggcag atttctcgtg ccgaatccgc ctgcaggaat 2564401 gatcgctttt tttatcatgg tattttcccc tcagctcatg tttattacat gatattccaa 2564461 gagcgcatcc cgatgtttgt acatctgaaa ttaggcggaa gcaactgggc agaaagcgga 2564521 atcacgaacc agcccttttt taataggata ttgatatatg accagtaatc ttgtaaagga 2564581 gctcaggtga tgaaaatttg tgtggttggc gccgggtatg tcggtttaac cctatcagcg 2564641 gcactggcat ccatcggaca tgacatgata tgcacagaca aagacgtcaa aaaaatcggg 2564701 cagctgaaaa aaggagtcat tcccttttac gagcctgggc tttcagatgc aatacttcgt 2564761 tgcggcaatc tctcgttttc ttctgaagtg aaatcgagca tggaggaatg tcccgttatt 2564821 tttatcgcag tcggaactcc gccgcgttcg gacggatcag ctgatacgaa agccctgcag 2564881 tccgtcatcg gtgatttaag cgaggcgatc cgatcgtata aaaccattat tacgaaaagc 2564941 actgttccgc ccgggacaaa tgaaaacata gcaaaacagc tgattgcctc cggagtgtct 2565001 aaaaacctct ttaatatcgt atccaatccg gagtttctgc gggaaggcaa tgccttatat 2565061 gacatgctgc atcctgacaa aacagtcatc ggtgttcagg aagaagatca cgtatcggca 2565121 gccatcgtca aatccattta caaacacatt gatacccctt ttatcgttac aagcttagcg 2565181 ggagcagagc tgatcaaata tgccaacaat ttctttttag cggccaaaat ttcgttcatt 2565241 aacgaaatgg cccgcatatg tgaagcctat caatcagata tctcagatat ttcccgcgct 2565301 atcggtctag acccaaggat cgggaagcac tttttgcagg caggcatcgg atacggaggc 2565361 tcttgttttc caaaggatct gcaggcgctg caatttgctg cccaggaaaa aaacacggag 2565421 accttcctgc tccgggccgt gcagcacatt aatgacaccc agcttggcct gtatatcaaa 2565481 aaaatacagt cattcttcga aacacttcaa ggcaagaaag cggctgtact cggcatttcc 2565541 ttcaaaccga atactgatga catccggaat tctcaggctg tcagactgat ggaaaggctg 2565601 gcggagctgg gatgtgatgt tcatgcatat gatcctgaag ctgtacttcc agaacatttg 2565661 cggcaacatg taactcagca ttctcaagct tttgatgcga tcgaagagag tgacttttta 2565721 tttttggcga cagaatggtc tgagttttta gcgtttgatt ggaaaaaggc tgcagatatc 2565781 atgaaagggc gtcttgtgat tgacggacgc aacgtactaa aaaaagaact gatcgaggct 2565841 tgcggcctga tctgtacggg agttggccgt ccatgaaaat actcgtcaca ggagcagcgg 2565901 gctttatcgg ctcccacctc tgcgaagaat tactaaaaga taagaaacat aacgttatcg 2565961 gaatcgatga ctttatcggt cctactccat tttccttgaa attaaaaaac cttaaaaacc 2566021 tgctgccgga aaagcgattt acgttcataa aggaaaatct gctgacagcc gatcttgctt 2566081 ccttactgga aggagtggac gtcatctttc atttggcggc cataccgggt gtccgctcaa 2566141 gctggggcaa tcattttcac ccatatgccg cacataatat ccaagcgctc caaaggctcc 2566201 tcgaggcgtg ccgggaacat tctattcaaa cgttcgtctt tgcatccacc tcttccgtct 2566261 atggcgaaaa acaaggaaaa gtcagcgaaa acacgtcgct ttctccttta tctccgtacg 2566321 gggtaacaaa gcttacggga gaaaagcttt gccatgtgta taaacagagc tttggcattc 2566381 caattgtgat tctccgtttt tttaccgtat acgggccaag acagcggccg gatatggctt 2566441 ttcaccggct cattaagcag caccttcagc aaaagccgct taccatcttc ggtgatgggc 2566501 agcagtcaag agatttcact tatatcagcg actgtgtcaa aggcatcacc gctgttcttg 2566561 ggaaacccca ccttattggt gaaacagtaa atatcggcgg cgcagagcgt gcctcagtct 2566621 taaaagttgt ctccctcatt gaggatattt ccgggagaaa agcaacactg cacttttcgg 2566681 acaaaatagc aggggaaccg agcaacacgt gggcggatat ttcaaaagca aaacagctct 2566741 tgcattatga tcccgccaca tccttaaagg atggcttgac caacgaaatc gcctatttat 2566801 cgtcgctgta tcagggggaa taaaaatgaa gcttgccttt atctgtacag aaaagctgcc 2566861 ggcgcccgca gtacgcggcg gcgctattca aatgatgatt gacggtgtca cgccctattt 2566921 cagcagcagg tacgacctga ccattttttc aatagaagat ccatcgctcc caaaaagaga 2566981 aacaaaagac ggcgtacatt atatccatct gccaaaagaa cattaccgcg aggcggtagc 2567041 cgaagagctg cgagcctctt cctttgacct cattcatgtg ttcaacaggc ctttaaatgt 2567101 ctctttatat aaaaaagcct caccaaacag caagatcgtt ctgagcctgc ataacgaaat 2567161 gttttctgaa aaaaagatga ccttcgcgca aggaaaagaa gtactcgaca atgtctccat 2567221 gatcacaaca gtgagcgaat ttattaaaca aaccgtcatt gaacgtttcc ctgaagccga 2567281 ggacatcaca aaagttgtgt attccggcgt tgatttaaac tcttatccgc ccgtctggac 2567341 gatgaaaggc tcggctgtca gaaaaacata ccggaaaaaa tacggtattg aagataaaaa 2567401 agttatttta ttcgccggcc gcttaagccc gacaaaaggg cctcaccttc tcattcacag 2567461 catgagacgg attttgcagc agcaccctga tgctgtactg gtcatagcag gcgggaagtg 2567521 gttcagcgat gacagcgaaa accaatatgt cacctatctg cgcacgctgg cgctgccata 2567581 cagagaccac ataatcttta caaaattcat tcccgcagac gatatcccaa acctttttct 2567641 gatggcagat gtatttgtgt gcagctctca gtggaacgaa cccctcgccc gtgtgaatta 2567701 tgaagcaatg gcggccggca cgcccttaat taccacaaac cggggcggaa acggtgaagt 2567761 cgtaaaacac gaagtcaccg gccttgtcat cgatagctac aacaaacctt cttcatttgc 2567821 aaaagcaatt gacagagcct ttacagatca agaattaatg aacaaaatga caaaaaacgc 2567881 ccgaaagcat gtagaagctt tatttacctt tacccatgct gccaaaaggc tcaatactgt 2567941 ttaccaatcc gttctgaccc cgaaaaacaa acaatttccg ccgccttttc tgacgcaaaa 2568001 ttttgattta tcatctatca atcagctttt tgtgaaagca aaaacataaa acctacagct 2568061 cgtgttgcaa aacgggctgt tttttcgcta cagagaactt aaaaaaaggc ataaatgtga 2568121 ctttatgcct tgcgctttac agtttgagaa aaccatggag ctggtttaga ttcacttgga 2568181 agaatgatga tttccacttt agcttcttcc gctaagtctg gttcttcatc ttcatcctct 2568241 tcttcatatg ggggcgctga gcgtttcgaa tcacgctcct cctcaggctc cagagtggtt 2568301 tcgaattttg tttcttcttc atcatcgacg attttgcgat ctgtttcctt ttccttcgtt 2568361 tctttttgat attctttcgg tgcattgatg tgagggagct ctcgaatgct gcccacatct 2568421 aaatgcttct cctcttcttc cttctcagct gagattgagt catgagcctg ccatcccatc 2568481 ggtccaggcg gtgtaaatac gaattggtcg agatccagtt tagaaataga ggctttttgt 2568541 ctcgatgacc tcatgtcaat tcgcctcccg atacgctttt atctttttat acagttccgg 2568601 cagtttatcc aaaaacgaat ctttagattc ttcaacagaa atcatgtttt gcagcgccca 2568661 gttatacttc tcatctgacc acgttttctt ttgcttcaaa taatatttgt gcccgattgc 2568721 acagaacaaa tgcggaaacg cgagatcaat ccaaagtacc tcgtactgtt tttctgtgag 2568781 cggatacact gcgtcgtagg ccgcaagcag tgcaaccatg aaatcagtat cccatacaga 2568841 aagcttaacc atcactttat tcagcagaat acgaaggtct cttgacggca aatcgtaggt 2568901 aatcgagtga agctccttta aaaaaggctc cccttcgatc tcagtcaaac gtgccaatgt 2568961 aaaatcctga aaacagaatc cgccatgctc gagtgtctct tttgtccagg tttcgtattc 2569021 tgagtcatca agcgctctga gagcttcttt tcctcttgcc agcattttat cagcatgttt 2569081 taagaaagtt tgcgaaaata cgtcatcagg ataggatgct gcgatctgca tattcccttc 2569141 aagttcctgc agcttccaac ggtacaattt gtgccatttt cccagcctgc ttctcttctt 2569201 gctttcatct gtgcaaacat atccttttga ggcatgatga aaatggccgg caaatgacat 2569261 gacttttttc atttgctctg catcatagta aatcatttct tttcctgtca ctttgtcata 2569321 taaactgtaa gaaacctgat ccgtgcccaa gcagctaccg ccattttttg tttgatgaat 2569381 cggcgctatc ggcagccctt tctcttgtaa atgggcgtgt gcctgagtga taaaaagcat 2569441 ccgctccggt ttcatttgcg cttcttttag cagctttggg ccatgatcag tttcgacttc 2569501 ccagattttg cgcccgcttt tgttcgattt cagcgccaca tggtcgatat gaaacggata 2569561 ataactgaga atttcggaca caatctgttc ttcatgctct ttttggtaca ctctgttcac 2569621 cccttctatc tgttcttttc atagacgctg agcagatttt cagccaccct ctgccagcca 2569681 aaattgcttt ctgcctcacg gcggctgtat ttcccaagcc gttcccgctt ttccgagctg 2569741 ctcagcaaat cattgatacg ttcggcatat tgtttaggat tttcaaagtc atgaatgatg 2569801 tagccgtttt tcccttcctc tatgacctct ggattgcctc cccgattgct tgtaataata 2569861 ggaagtcccg cagccatcgc ttcataatgc acccttgcta aaggctcctg ccattgcgaa 2569921 gagcatacaa atacatctga catggtataa aggcgcggaa tgtcctttgg cttcacaaat 2569981 tgaataaatg tgacatgatc cttttgcatc gcaccaaggg tatgaagatg tttgacatag 2570041 ttatttaatt cattatctcc gaaccatttt gacccgataa acaccatcat gacatcgggg 2570101 tgctcctcaa tgatgtccgg caaagcctgc aataatatgt gcgggccttt gactttgcta 2570161 agccggccga caaacaagac gatttttttg ccgtgaagcc ccagctcgct tcgcatctct 2570221 tcgcgagctc gctgcccttc attcgtccag cgagggtggt acgtttttaa atccacacca 2570281 gaatacaccg tttttgtttt tgatcgtgct gacggaaaac ggcttgtgat cgtctgtccg 2570341 atataatcgc tgaccgtaac aatctgcgct acggagtcga tgcaaatctc gccttccgcc 2570401 tggctgattt tatcgtaagc gaacatttca ttgtgaacgc ttaaaataaa aacagcatcc 2570461 ggcgcctgtt tcttcaattt cggaacccag cttgggcgat tacaaacatg cacaagatca 2570521 aaacggctct ttttcagctc tgctccaacg gcttcttcat aacggtcttc atccaaatgc 2570581 acataatgga caccgtctac cttctctcta tcagcgagat tcggatcttt aatagaaaac 2570641 acagtcacct catgtttttt tgcaattaaa ggggcaaccg cttcgaggta gatttgaatg 2570701 gcgcctcctc gaaccgatgg gacaggaagc ttctctgtgg cgatcagtgc tattttcata 2570761 catagcctcc attcctgcat gatttttaac tagttagaat catgatacgg ctgaacaacc 2570821 aacttgtgcg gaatgggact gccctaaaaa caaaacgggt aaacaaccag attcatctat 2570881 taaatatagt caaataactc aatcattttt tccttttgat tcataaggta ggagtaaaac 2570941 aggtaaggat gtgtccttta atggcagaaa accatgaagt cattgaggag gggaattcat 2571001 cagagcttcc tttatcagca gaagatgcaa aaaaattaac ggagctggct gaaaatgtgc 2571061 ttcaaggatg ggatgtgcag gctgaaaaaa tagacgtcat tcagggaaac cagatggcgc 2571121 ttgtctggaa ggtccacaca gactccggcg cggtttgtct aaaacgaata cacaggccag 2571181 aaaagaaagc gttgttttcc attttcgcgc aggactattt agcaaaaaaa ggcatgaatg 2571241 ttcctggcat actcccaaac aaaaaaggca gcctatattc taagcacggc tcatttctat 2571301 ttgtcgtata tgactggatc gaaggaagac cgtttgagct gactgtaaag caggacttgg 2571361 agtttatcat gaaaggcctt gctgattttc atacagcttc cgtcggatat cagccgccaa 2571421 atggcgttcc catatttacc aaattaggtc gctggccgaa tcactacacg aaacgatgca 2571481 aacagatgga aacgtggaag ctgatggcgg aggcggaaaa agaagatcct ttctcacagc 2571541 tttatcttca ggagatagat ggctttattg aagacgggct gcgcatcaaa gaccggcttt 2571601 tgcaatcgac ctatgttcca tggactgaac agctgaaaaa aagccctaac ctttgccacc 2571661 aggattacgg aaccgggaat acactcttag gagaaaatga acagatttgg gtcatcgact 2571721 tagataccgt atcatttgat ctgcctattc gcgatttgcg caaaatgatt attccgcttt 2571781 tggatacgac gggtgtttgg gatgacgaaa catttaatgt catgctgaac gcatacgaat 2571841 ccagagcccc attaactgaa gaacaaaaac aagtcatgtt tattgatatg ctgtttcctt 2571901 acgagcttta cgatgtcatt cgcgaaaaat acgtccgcaa gtctgcttta ccgaaggaag 2571961 aattagaatc agcttttgaa tatgaacgca ttaaagcaaa cgcattgcgg cagcttattt 2572021 aagaccatca tttcccccgc atatcggggg tttgatattt ataagataaa gggtaattaa 2572081 atacatgcgg aggttgcaaa tatgaaaaag attgtcggcg ctttagccgt ttttgtgatt 2572141 acatatgcgc tgttttcagc cgcaggctac ctgtttcctg tggaccaaga atggtacaat 2572201 tcattgaaaa aaccggactg gacgccaagc ggaactgcga tcggcatcat ttgggccatc 2572261 ctgtttgccc tgatctccct ttcagcagcc attgtatatg ctgcgttttc atttaaaggt 2572321 gcgaaaagct tttggtttac acttttgata aattacgtgc tcaatcaagc cttcagctat 2572381 ttccagttta cgcaaaaaaa tctgctggct gcatcgcttg actgcctgct tgtcgccatc 2572441 acagcaatcg tattactgat cattgccaaa aaatacagca gagccgcaag ctatcttctt 2572501 ttgccttatt ttttatggag tgcatttgcg acgttcttat cctttacaat caattcaatg 2572561 aatctgtgaa caaaaaaagc cgcttataca gcggcttttt cacatcatcg gcttgatgcc 2572621 ccaaatgtcc ttcgcatatt cccggatcgt gcggtcgctg gagaaatatc cagaatgagc 2572681 aatgtttaca atcgaatgct cagaccattt ccttcgctct cgataatcag cttgaattcg 2572741 ctcctgtgca tctgcatatg agctgaaatc cttcagcaca aaatactcat cattatgcgg 2572801 aagcagcgag tcaaagatcg attcaaattc atctgcctct ccttcaaaaa aaccattgat 2572861 caactgatcc gctacctgcc tgattctcct gtcatgctga taatattccc tcgacctata 2572921 gccgccgttt tcctgatacg atagaacctc atccgccttt aagccgaacg tgtaaataca 2572981 gtcagggccc acccgctcaa ggatctcgat atttgcgccg tcatgcgtgc cgatcgtcaa 2573041 agccccgttc atcataaact tcatattccc tgtaccagac gcttccttgc ttgcggttga 2573101 aatttgctca cttacgtctg atgccggaaa aattcgctca gccatagaaa ctctataatt 2573161 ttctaaaaaa acaactttga tcagctgttt gaccgccgga tcataattga ctttttctgc 2573221 gacagaatgg atcagcttaa tgattttctt ggcataataa tagcttggtg aagcctttgc 2573281 cccgaaaata aaggtttgcg ggtagattga aaaccccgaa tcctccttga ggcggttata 2573341 caaatacata atgtgaagaa cattcagcag ctgccgttta tatgcatgaa gccgtttcac 2573401 ctgtacgtcg aatatgctct cagggttcac aaccaccccg gccgtgcaaa aaatcaaatc 2573461 ggcaagctct tgttttttct tgcttttgtt gttttgaaac tgttcaataa atgcaggatc 2573521 agtggcgtac ggttctaaac ggatcagtga ttccggctgc ttgacccatt catcgccgat 2573581 cgcctctgta atgatggcag acaagcctgg attcgctttt aacagccagc gcctgtgggc 2573641 aattccattc gtcttattgt taaaacgatt cggaaacagc aagtgaaagt cgcgcatctc 2573701 cctttccttt aatatatcgg aatgtatttt tgcaacgcca tttacactgt agctgcctac 2573761 tatggccaga tgagccattt tgacaacacc atgcgctgta atcgccatgt tctctatcct 2573821 tttccagtct ccaggatact tttcccaaac tgcacggcaa aacctctcat tgatctcttc 2573881 aataatcatg tacattcgcg ggagcagcgg cttaaacaaa tgaatcggcc atttctcgag 2573941 cgcttctgac aatgttgtat gatttgtata agaaatcgta tgtacagtga tatgccaagc 2574001 ttcttcccag ctcatgttct cttcatcgag caaaatccgc attagctcag gcaccgcaag 2574061 cgcagggtga gtgtcattaa tatgaatgct cactttttta tgcaggccgg ataaagattt 2574121 atgtgtttta cggtaattgt tcacaatgct ttttaagctt gcgcatacta aaaaatactg 2574181 ctgcttcagc cgtaaaattt tcccctcatc atgggtgtca tcgggatata agaattcaga 2574241 aaccgcttct gtttctcgct tataagacaa aatattaccg ccgtgataat gggcataggg 2574301 ctcggcgttc caaagcctta acgtgttgac agtgcccgtt tcatagccga tgatcgggat 2574361 atcataagga acagcggtaa caattgtcgc ttgttcatgg cgaaaatgca ggcgcccgct 2574421 tttttctgtc atatggactt cgccccaaaa cggcacgtcc actgcttgat ccgcattcct 2574481 tacttcccat acgttcccgt ttttcagcca ttgctcaggc agctccacct gatgtccgtc 2574541 tacaattttt tgctcaaaca aaccatgctt ataacgtatg cccatgccgt gcccaggcag 2574601 gttcaacgaa gcaagcgaat ctaaaaagca agcggccaag cgcccaagtc cgccattgcc 2574661 gagacctgca tcgttctcta tctgaaggat ctcctctaaa ttgatgccga tttcctttaa 2574721 accagcttct acaacatcac gaacaccaag attcattaag ttttgctcaa ggagctgacc 2574781 gagcagaaat tcgattgata aataatatgt ctgcttcccg gaatttgatc tgcttttttc 2574841 attcgtttcg atccaatcag cgctgatata ctctctgacc atattgccca acgttttata 2574901 ttgatccagc ttggcagaat ctttaaagct ttttccgcac gtcatttcca gacgctttaa 2574961 aaataagtct gcaaagcgtt ctttactcga gaacatcccg tccactcctt gtcacctgct 2575021 cgaaaatacg ctgatactct ttagccgact tcccccagct gtaatctgca ttcatagcgg 2575081 tcttcacgat gctcttccat acatcctgtt ggcaataaaa cgacagcgcc ctttctatcg 2575141 taaatttcag atcatgcgca ttaaaggcgg aaaacgtaaa gccattgccc gttccctctt 2575201 cctcctgata ggcacggaca gtgtcgtaaa gaccgcccgt ttccctgaca atcggaatgg 2575261 cgccatattg aagagcaatg agctgcccca aaccgcacgg ctcaaatttc gacggcatca 2575321 aaaacatatc agagcccgca taaatttgat gggctagcgg ctcatcaaac ccgatataag 2575381 cccggcactt ctcatgaaaa gcaaattctg cataccggaa ataatcttca aattcacgtt 2575441 ctcctgtgcc tagcacaacc agctgtatgt cttgctcctc aagaagttcg tgcataattc 2575501 tgcggacaag atcaagcccc ttttgtttag tgagccttgt caccatactg atcagcggaa 2575561 tatcgttttt ctctggaagc cccatccgct gctgaagctt cgttttgttt tccagcttgc 2575621 atgcaagatc ccctgaatcg tattgcgcct ctatataagg gtcgcttttc ggctgataga 2575681 acgtatcatc aatgccattt aatatgccgg ttacatcatc ttccctatat tgcaaaacct 2575741 gttccaactg ctcaccataa tacggcgtca tgatttcatt tctgtaagtg gggctcacag 2575801 ttgtcacatg atcagccgca atgatgcccg ctttcataaa attaacaaat ccgttgcatt 2575861 ctaacctttc ataatgaaaa tgatccatct caagacccag caagtcatgt gtgacatcag 2575921 gagggaatat gccttgaaac tgcaggttgt ggatcgtgag cacgcttttc atccgttcat 2575981 aaaaaggatg ttttctgtac tcctctttca gcaaataatt gaccatcgct gtatgccaat 2576041 cgtgagtatg aacaatatcg gcttgaacat tcacaacttt ggcagcctcc agcacagctc 2576101 ttgaaaaaaa ggcaaaccgc tcaccgtcat cataatgccc gtacaacgaa tccctgttga 2576161 aatagtactc attgtcgatg aagtaataat tcacatcatt ctctgccata tgttcaattc 2576221 cgcaatattg ctgccgccag ccgacagcta cggtacactc agcctgtttt ttcatacgct 2576281 ttttccacgg ttcaggtatt tggctgtact tcggcagcat cacagctacc tcattgccta 2576341 atcgcgcaag cgcctttggc agagcacctg ctacatcggc aagacctcct gatttcacaa 2576401 atggggtgca ttctgacaca gcaaataata tcttcaagaa ttcatcagct ctccttgcac 2576461 caaacctttt cttaatacaa gcggctgctc agctgttcct gcagcttccg tcgccttgcc 2576521 gattttaaca tccttatccg aaatgacctg ctcaagaaga caatcctctc caatctgcgt 2576581 tttttgcata ataatgcagt ttttcagctt cgtacccttt ccgacatgga ccgccctgaa 2576641 caaaatgcag ttttcaacct ctccttcaag cacacagccg tttgccacca aagaattttt 2576701 gacagtgctg tgctttccgt atttcgtagg cggctcatcc ttcacttttg tatagatcgg 2576761 ctgctgcggc aaaaacacct gctgccaaaa acgaggctga atgagctcca tactgtgggt 2576821 ataatatttt tccaccgaat caatgacagc ggcataacct gaatattcat aagggcaaat 2576881 ggtcagggcg gaagattcct tttcaacagc ctcctgaatg gttttatagc ctttttcgct 2576941 atgtccgtag atcagatcct ttaaaagcgt tgttgacatg atatagattt gcagcgactg 2577001 gccgtcctga aatacctcgg tgacgtcgca gccaacctcc tgatggcgtt tcagcacata 2577061 ttgaaattga atgttgcata cggtatggct gttggagatt acagcatatt gctgagtgct 2577121 tctgtggaag taatctagat ggtccgaaaa ctggcgaaag gaaccgaatt catcgtattc 2577181 gtgatgaaga tggggagacg ggaaaaaaaa gaggccgtcc tttttccggt gcaaatccca 2577241 ttccttaccc gccccaaggt gatccatgag cgaacggtaa cgatacttcg gaaaaattgc 2577301 aacactccta atatccgcat tcaccatgtt ggaaagcata aaatcaatca gtcggtacct 2577361 gccggcaaaa gggatcgccc cgagcgaccg ctgtgctgtt aaatcctgaa gagaatgctt 2577421 atatgtggtt tcatctataa cacctaacat ttgattattg aacactgact ctgccccctc 2577481 ttcagtaatt aaatcaattc tttttctaca aattcctctg aaacgagcag cacctcttca 2577541 atgtcttttt cggagcgaat cactgcgcca tccggcagca ccatcccatt aggaacgatg 2577601 gcattttcaa tgactacatg ctccccaatc gtcacatccg gcattatgac ggatgatgta 2577661 acagtcgtat gcttaccaac agtcacacct tgaaaaagaa cggagtgaga cacatttcca 2577721 tatacaacac aaccttcgtt cacaagcgaa tcttgaacct gcgcatcaga tgaaataaat 2577781 tgcggaggct gatttggatt gacggagtaa attttccatt tgcgttcaaa cagcttcagc 2577841 tccgagtcct cttttaacaa atccatattg gcttcccaca agctctgcac cgttccgaca 2577901 tccttccaat atcccttgaa cggataagca gaaagcttct ttttctcttc caaaagcagt 2577961 ggaataatgt ctttgccgaa gtcgtggcta gaataagggt tttgatcgtc catctcaaga 2578021 tactgtttca aaagcggcca attgaatata taaattccca ttgaggcaag attgctctta 2578081 gggaatttgg gcttttcatc aaaatgtgtg atcgtcccat ctggattggc cttcatgatg 2578141 ccgaaccggc ttgcttcctc ccagcccact tcgatgacag agatggtcac atctgctttc 2578201 ttttcaatgt gataatcaag cattttgccg tagtccattt tgtatatgtg atctcctgat 2578261 aaaatcagta catactcagg atcatactga ttcaaataat tgagattttc ataaatggag 2578321 cttgccgtcc ctttatacca tttgacttct gatgactcgg cataaggggg taaaaccgtc 2578381 acgccgccat tatatctatc caggtcccat gcactgccga tcccaatata ggaattcagc 2578441 tcgagcggct gatattgcgt taaaatcccg actgtgtcta tgcctgaatt agaacagttg 2578501 cttagggtaa aatcaataat cctgtatttt cccccgaaag atacagccgg tttggccata 2578561 ttttttgtta atccgctgag acggctgccc ttcccgccgg caaggagcat ggctacacat 2578621 tgttttttca tctttttatc tctcctcttt ttttaaccgc ccgtaaaatc gagatgccgt 2578681 aaggggggat ggtcatcgtg atataacacg gtttatgatg aagtgctccc tttttagccg 2578741 ataacggctt tttgttgatt tgccctgagc ctccatatgt ttcactgtca ctgttaagca 2578801 cttcaatgta ttgagtaaaa aaaggaactc caacatcata ttgatgatag accacgggtg 2578861 taaaattaca aatgatgaca agcgcctcac cgtgcttttg gccataacga ataaaagaaa 2578921 agattgattg ttcgtcatta tggacatcaa tccattcaaa cgattgtgca cgatggtcat 2578981 gctcataaag gattttgctt ttttggtaaa agcggagaag atcttgcgta aaaacgctgg 2579041 ctttctgatg catggggaag gagtccaaaa accaatcaag ctgttctgta tctttccatt 2579101 catcaaattg agcaaactct gatcccataa agatcaattt ctttccggga tgcactgtca 2579161 tatagcccag caaaagccga tactgggcaa atttctgcca gtagtcgcca ggcattttat 2579221 tgagaagtga tttttttccg tatacgactt catcatgaga aaacggcaat acaaaatgtt 2579281 cactaaacgc atatagtaat gaaaaagaga taagctgatg acaatgccgc ctttcttcgg 2579341 gcggcgtctc catgtatttc agtacgtcat tcatccatcc catattccat ttataatgaa 2579401 aaccaagccc cccttcctca acggcacctg tcacttgagg ccattctgta gaatcttctg 2579461 caatcatcat cacatgggga tatgcctctc tcatggtttg attgagtttt tttaaaaaat 2579521 caacagcata tggattcgtg tggcgttcat cctgatttgg ccaatacaag atattagcca 2579581 ctgcatcaac cctaaatcca tctatatgat agaattccgc ccagtacaac gcattcgaaa 2579641 ttaaaaaact atgaacttcc ggtttcccca ggtcaaagtt tgccgtgccc cataaccagt 2579701 tctcccgatc acgttcttct ttgtattcat aaagcggttc tccatcaaac atataaaggc 2579761 catgtgcatc tttacaaaaa tgtccgggga cccaatccaa aatgactccg atattttgtt 2579821 gatgacattc atccacaaac ttcatcagat catgcggcgg gccaaacctg cttgtcgggc 2579881 tgtaataccc cgttccttgg tacccccatg aacgatcata tggatgctca tacacgggaa 2579941 gcagttcaat atgggtaaac ccatgcttct tgatataagg gataagcgtc tgacttaatt 2580001 ctttatagga ataatgcctg ccatcagaat gcttcttcca agacccaaga tgcagttcat 2580061 aaatgaaaac aggtttttca tacagcgtct tagccttctg tttcttttgc catttttgat 2580121 cttgccagct gtatccttcc aaatcgtaag taagtgacgc tgtgtttggt ctgacttctg 2580181 aataaatagc gtatggatct gccttcagcc tgatctcacc gttattcgtc acaatttcgt 2580241 atttatatcg ttccttttct cctatacctg gaataaataa cgtccaaatg ccattatcat 2580301 tcactctgtg catcacatgc tcttctccag accagctgtt aaaatctcca gccactcgta 2580361 cttccgacgc atgaggcgcc cacacacaga attcatatcc gcttttgcca ttcagctcgc 2580421 ggtaatgcga gccaaacagc tgatagcttt taaacagact gccttcgtga aaaagataaa 2580481 catcatgtgc tgtcgggctg gcagcggcca tgtaatcatc ctttctgaca tcatagtttt 2580541 catttatagt atttattcga agaaataaaa aaaagccctt tcctgaaagc gcttatactt 2580601 atagacaatt aacttcattt tctgaagaaa aacgaaatat atggagattt ttgtagtctg 2580661 tttttaaaat aaagaacaaa atctaagaca tatcatgatt tataaaaaca aaaaaacctt 2580721 gcaggatatg caaggcttct ggatgacccg tacgggattc gaacccgtgt taccgccgtg 2580781 aaagggcggt gtcttaaccg cttgaccaac gggccgataa ttatgatatc tgtaatcata 2580841 tggcggagaa ggagggattt gaaccctcgc gccgcttaca cgacctacac ccttagcagg 2580901 ggcgcctctt cagccacttg agtacttctc catttggctc cacaggcagg attcgaacct 2580961 gcgaccgatc ggttaacagc cgatagctct accactgagc tactgtggaa caaaagtcat 2581021 ggtgggcctg aatggactcg aaccatcgac ctcacgctta tcaggcgtgc gctctaacca 2581081 gctgagctac aggcccatga cgatatagaa atggagcggg tgatgggaat cgaacccacg 2581141 acatcagctt ggaaggctga ggttttacca ctaaactaca cccgcaattt ttatttgggg 2581201 cgattgatgg gaatcgaacc cacgaatgcc agagccacaa tctggtgcgt taaccacttc 2581261 gccacaaccg ccaaagcata ttgataaatg gtggctcggg acggaatcga accgccgaca 2581321 cacggatttt cagtccgttg ctctaccaac tgagctaccg agcctaagta tttaaatggc 2581381 ggtccggacg ggactcgaac ccgcgacctc ctgcgtgaca ggcaggcatt ctaaccaact 2581441 gaactaccgg accattttaa aatttggttg cgggggcagg atttgaacct gcgaccttcg 2581501 ggttatgagc ccgacgagct accgaactgc tccaccccgc gatgattagg aatatgtatg 2581561 gcggaggaag agggattcga acccccgcgg gctttgacac ccctgtcggt tttcaagacc 2581621 gatcccttca gccagacttg ggtattcctc cgtatagtgg tggaccttgt aggactcgaa 2581681 cctacgaccg gacggttatg agccgtctgc tctaaccaac tgagctaaag gtccattggt 2581741 agcggcggag gggatcgaac ccccgacctc acgggtatga accgtacgct ctagccagct 2581801 gagctacacc gccaaatatt tttgaaatca agtggagcct agcgggatcg aaccgctgac 2581861 ctcctgcgtg caaagcaggc gctctcccag ctgagctaag gccccaagaa tggtcgggaa 2581921 gacaggattc gaacctgcga ccccatggtc ccaaaccatg tgctctacca agctgagcta 2581981 cttcccgatt tcatatagat catggcgcgc ccgagaggag tcgaacccct aaccttttga 2582041 tccgtagtca aacgctctat ccaattgagc tacgggcgca aaacttaatg ccgagggccg 2582101 gacttgaacc ggcacggtag tcacctaccg caggatttta agtcctgtgt gtctgccaat 2582161 tccaccaccc cggcgtggat ggtatagttg gagcggaaga cgggattcga acccgcgacc 2582221 cccaccttgg caaggtggtg ttctaccact gaactacttc cgcagaaatg gtgcggatga 2582281 agggacttga acccccacgt ctgtaaagac actagagcct gattctagcg cgtctgccaa 2582341 ttccgccaca tccgcaacat gtaaatggtg agccatgaag gactcgaacc ttcgaccctc 2582401 tgattaaaag tcagatgctc taccaactga gctaatggct cttcttacaa tagacttgaa 2582461 tattatatca tataaaagtg gtgccggcaa gaggacttga acccccaacc tactgattac 2582521 aagtcagttg ctctaccaat tgagctacac cggcatatat gtaaaaccga tatgtataat 2582581 gaaaaatggt ggaggatgac gggctcgaac cgccgaccct ctgcttgtaa ggcagatgct 2582641 ctcccagctg agctaatcct ccatacttgc actaacgtgc aattgcttgg cggcgtccta 2582701 ctctcacagg gggaaacccc cgactaccat cggcgctgaa gagcttaact tccgtgttcg 2582761 gtatgggaac gggtgtgacc tcttcgctat cgccaccaaa caaattgaga gtgttctctc 2582821 aaaactagat aacaggtgtg acatcattca aaaatatggt taagtcctcg atcgattagt 2582881 atctgtcagc tccatgtgtt gccacacttc cacctcagac ctatcaacct gatcatcttt 2582941 cagggatctt acttccttgc ggaatgggaa atctcatctt gaggggggct tcatgcttag 2583001 atgctttcag cacttatccc gtccgcacat agctacccag cgatgccctt ggcagaacaa 2583061 ctggtacacc agcggtgcgt ccatcccggt cctctcgtac taaggacagc tcctctcaaa 2583121 tttcctgcgc ccgcgacgga tagggaccga actgtctcac gacgttctga acccagctcg 2583181 cgtaccgctt taatgggcga acagcccaac ccttgggacc gactacagcc ccaggatgcg 2583241 atgagccgac atcgaggtgc caaacctccc cgtcgatgtg gactcttggg ggagataagc 2583301 ctgttatccc cggggtagct tttatccgtt gagcgatggc ccttccatgc ggaaccaccg 2583361 gatcactaag cccgactttc gtccctgctc gacttgtagg tctcgcagtc aagctccctt 2583421 gtgcctttac actctgcgaa tgatttccaa ccattctgag ggaacctttg ggcgcctccg 2583481 ttacctttta ggaggcgacc gccccagtca aactgcccac ctgacactgt ctccccgccc 2583541 gataagggcg gcgggttaga aggtcaatac agccagggta gtatcccacc gatgcctcca 2583601 ccgaagctgg cgctccggtt tccaaggctc ctacctatcc tgtacaagct gtaccaacat 2583661 tcaatatcag gctgcagtaa agctccacgg ggtctttccg tcctgtcgcg ggtaacctgc 2583721 atcttcacag gtactataat ttcaccgagt ctctcgttga gacagtgccc agatcgttgc 2583781 gcctttcgtg cgggtcggaa cttacccgac aaggaatttc gctaccttag gaccgttata 2583841 gttacggccg ccgtttactg gggcttcaat tcgcaccttc gcttacgcta agcgctcctc 2583901 ttaaccttcc agcaccgggc aggcgtcagc ccctatactt cgccttacgg cttcgcagag 2583961 acctgtgttt ttgctaaaca gtcgcctggg cctattcact gcggctctct cgggcttgca 2584021 ccctaacaga gcaccccttc tcccgaagtt acggggtcat tttgccgagt tccttaacga 2584081 gagttctctc gatcacctta ggattctctc ctcgcctacc tgtgtcggtt tgcggtacgg 2584141 gcacctctca cctcgctaga ggcttttctt ggcagtgtgg aatcaggaac ttcgctacta 2584201 tatttcgctc gccatcacag ctcagcctta tgggaaacgg atttgcctat ttcccagcct 2584261 aactgcttgg acgcggatat ccaataccgc gcttacccta tcctcctgcg tccccccatt 2584321 gctcaaatgg tgaggaggtg gtacaggaat atcaacctgt tgtccatcgc ctacgccttt 2584381 cggcctcggc ttaggtcccg actaaccctg agcggacgag ccttcctcag gaaaccttag 2584441 gcattcggtg gaggggattc tcacccctct ttcgctactc ataccggcat tctcacttct 2584501 aagcgctcca ccagtccttc cggtctggct tcacagccct tagaacgctc tcctaccact 2584561 gttcgaagaa cagtccgcag cttcggtgat acgtttagcc ccggtacatt ttcggcgcag 2584621 agtcactcga ccagtgagct attacgcact ctttaaatgg tggctgcttc taagccaaca 2584681 tcctggttgt ctaagcaact ccacatcctt ttccacttaa cgtatacttt gggaccttag 2584741 ctggcggtct gggctgtttc cctttcgact acggatctta tcactcgcag tctgactccc 2584801 aaggataagt cattggcatt cggagtttga ctgaattcgg taacccggta ggggccccta 2584861 gtccaatcag tgctctacct ccaagactct taccttgagg ctagccctaa agctatttcg 2584921 gagagaacca gctatctcca ggttcgattg gcatttcacc cctacccaca cctcatcccc 2584981 gcacttttca acgtgcgtgg gttcgggcct ccattcagtg ttacctgaac ttcaccctgg 2585041 acatgggtag atcacctggt ttcgggtcta cgaccacgta ctcatgcgcc ctattcagac 2585101 tcgctttcgc tgcggctccg catcttctgc ttaaccttgc acgggatcgt aactcgccgg 2585161 ttcattctac aaaaggcacg ccatcacccg ttaacgggct ctgactactt gtaggcacac 2585221 ggtttcagga tctctttcac tccccttccg gggtgctttt cacctttccc tcacggtact 2585281 ggttcactat cggtcactag ggagtattta gccttgggag atggtcctcc cggattccga 2585341 cggaatttca cgtgttccgc cgtactcagg atccactcag gagagaacga agttttgact 2585401 acagggctgt tacctcctat ggcgggcctt tccagacctc ttcatctacc tcgttctttt 2585461 gtaactccgt acagagtgtc ctacaacccc aagaggcaag cctcttggtt tgggctgatc 2585521 ccgtttcgct cgccgctact cagggaatcg catttgcttt ctcttcctcc gggtacttag 2585581 atgtttcagt tccccgggtc tgccttctca tatcctatga attcagatat ggataccact 2585641 ccattacgag tggtgggttt ccccattcgg aaatctccgg atcaaagctt gcttacagct 2585701 ccccgaagca tatcggtgtt cgtcccgtcc ttcatcggct cctagtgcca aggcatccac 2585761 cgtgcgccct ttctaactta accgttaaaa agaatcacta tgtgatatct tgtgttacta 2585821 attgaatgtg atgtctactg ttatctagtt ttcaaagaac acgtttcgaa ggaatgatcc 2585881 ttcaaaacta aacaagacag ggaacgttct gtttataaga ccttgggtct tatattccgt 2585941 ataatatcct tagaaaggag gtgatccagc cgcaccttcc gatacggcta ccttgttacg 2586001 acttcacccc aatcatctgt cccaccttcg gcggctggct cctaaaaggt tacctcaccg 2586061 acttcgggtg ttacaaactc tcgtggtgtg acgggcggtg tgtacaaggc ccgggaacgt 2586121 attcaccgcg gcatgctgat ccgcgattac tagcgattcc agcttcacgc agtcgagttg 2586181 cagactgcga tccgaactga gaacagattt gtgggattgg cttaacctcg cggtttcgct 2586241 gccctttgtt ctgtccattg tagcacgtgt gtagcccagg tcataagggg catgatgatt 2586301 tgacgtcatc cccaccttcc tccggtttgt caccggcagt caccttagag tgcccaactg 2586361 aatgctggca actaagatca agggttgcgc tcgttgcggg acttaaccca acatctcacg 2586421 acacgagctg acgacaacca tgcaccacct gtcactctgc ccccgaaggg gacgtcctat 2586481 ctctaggatt gtcagaggat gtcaagacct ggtaaggttc ttcgcgttgc ttcgaattaa 2586541 accacatgct ccaccgcttg tgcgggcccc cgtcaattcc tttgagtttc agtcttgcga 2586601 ccgtactccc caggcggagt gcttaatgcg ttagctgcag cactaagggg cggaaacccc 2586661 ctaacactta gcactcatcg tttacggcgt ggactaccag ggtatctaat cctgttcgct 2586721 ccccacgctt tcgctcctca gcgtcagtta cagaccagag agtcgccttc gccactggtg 2586781 ttcctccaca tctctacgca tttcaccgct acacgtggaa ttccactctc ctcttctgca 2586841 ctcaagttcc ccagtttcca atgaccctcc ccggttgagc cgggggcttt cacatcagac 2586901 ttaagaaacc gcctgcgagc cctttacgcc caataattcc ggaaaacgct tgccacctac 2586961 gtattaccgc ggctgctggc acgtagttag ccgtggcttt ctggttaggt accgtcaagg 2587021 taccgccctg ttcgaacggt acttgttctt ccctaacaac agagctttac gatccgaaaa 2587081 ccttcatcac tcacgcggcg ttgctccgtc agactttcgt ccattgcgga agattcccta 2587141 ctgctgcctc ccgtaggagt ctgggccgtg tctcagtccc agtgtggccg atcaccctct 2587201 caggtcggct acgcatcgtt gccttggtga gccgttacct caccaactag ctaatgcgcc 2587261 gcgggtccat ctgtaagtgg tagccgaagc caccttttat gtttgaacca tgcggttcaa 2587321 acaaccatcc ggtattagcc ccggtttccc ggagttatcc cagtcttaca ggcaggttac 2587381 ccacgtgtta ctcacccgtc cgccgctaac atcagggagc aagctcccac ctgtccgctc 2587441 gacttgcatg tattaggcac gccgccagcg ttcgtcctga gccaggatca aactctccga 2587501 taaatggatc acaggttaag ttcaccgcat cctgcggcga cacctgtgtg acctgcgtcg 2587561 tgcaggccct agtttgactg actacgcaca tcgcagtgcg atttttaaaa actgaattaa 2587621 caggtacgtt ttgtcttgtt tagttttcaa agatcatttc gttacttctc aatgaagcag 2587681 ctttactaat ataacattca gcttcttttt tgtcaacaac ttttttcaag ttgttttgaa 2587741 gcatctagtt tgtgtccgct gtgcatcagc gacgtttaat aatataacac ctgtatttat 2587801 ttattgcaat agttttttaa aaaaaatcta taaaacaaat aaactataat cctcgccatg 2587861 atttctaaag cgtgtgtatc atataagttt cttaaaagaa catatacatc agtcatgtga 2587921 tcttgttgtt tttttcgttt tcttgtatag tagaaacgaa ctaaatactg atgaccacaa 2587981 ggggagcatt aaagctgaga gtgagcggtt tcgttctgac cctttgaacc tgttagttaa 2588041 cgctggcgta gggatgtggc aaagtcaaat gaattgcaga tcgtaaagca gtgcgtggaa 2588101 cttttctcat ccttccgcgt gctgcttttt tgttgtcctt ttggttgtct gtcaatggaa 2588161 ggagatagat atgaatcaat ctaagcaact ggttcgcctt attgaaattg ccattatgac 2588221 agcggcagcc gttattttag acattgtctc aggaatgttt cttagcatgc ctcaaggagg 2588281 ctcggtctcc atcatgatga ttccgatctt tttaatttcg tttcgctggg gtgtcaaagc 2588341 aggtcttact acaggtttgt tgacaggtct agtacaaata gcaatcggaa acttgtttgc 2588401 tcaacatcct gtacagctat tgttagatta cattgtcgct ttcgcagcaa tcggcataag 2588461 cggctgtttc gcttcttctg tccgtaaagc cgctgtatca aaaacaaaag ggaaattgat 2588521 tgtttcagtg gtcagcgcag tttttatcgg cagtttgctg cgctatgccg cgcatgtcat 2588581 ttcaggagct gtgtttttcg gcagctttgc tccaaaagga acaccggtat ggatttattc 2588641 tttaacttat aatgcgactt acatggttcc ttcattcatt atttgtgcaa ttgtcctatg 2588701 tttattattt atgacagcac cccgtctgct taaaagtgac aaagcgtaaa agtaacaatc 2588761 ccccagcgaa ttccgctggg ggatttttcg ttatctgtta agaagtgttt ttaaagctga 2588821 aagatccggc cagccaagac ctacttcttt cagccttact ccggcaattt caaagttgtc 2588881 ctccgctact ctttcaggtg aataggcctg ataaaatata atcgagggat tctgctcaat 2588941 aacccaaaca aacatacttg aaaaaccatg ttgaagcaaa aactccgctc cttttgctaa 2589001 gagcgccctg cctgcacctt gccgctggcg ctcttccaga agataaatag cgtataactc 2589061 gccgtcatag ccttcttgtt cagagcgaat aggtccaaat gaagcaaagc cgaatactga 2589121 acccttttcg tcctgagcaa caaatactcc ctttaacgag cgacttttcc atttgtcttc 2589181 aaattcctta tagttcaggc tgtttaaata atcaatcggg ataatttcgt ggtatgttgt 2589241 cctccagctg tctacatgca cttttgcaat gtcctttata tcctctaact tcgcttcacg 2589301 tacagttacc atacggttct gccctttcct tactctgatt tttggatcgt tttggcttct 2589361 ttgatttcat ttgttaattc attaatgctt tgttttacgt ttccttttcc tgaaaagttc 2589421 tcaagcattt cttttacatc aattcctgag gatgctttta aactttcttg cagacttgac 2589481 attaagttcg tcgcatagct ggttactttg tttgctccgc ttgattcacc gcttcctcct 2589541 gtatcgacaa cggtgatttt atcaatattt gaaagaggtg ccgctgcttg tttcgcgtat 2589601 tccggaagca ttttgacaat catatcgaaa atcgccgcct gcccgtactg ttcaaaggcg 2589661 gccgcaattt tctcttttgc ttccgcttct gcaagacctt tcaggcggat aacctctgct 2589721 tctgtctctc ctttcgcttt ttccgcttct gcttttgcta gcccgtcaat tcttactttt 2589781 tccgcctcag cctttgccat tgcttcaata ctgtacttct tggcatcggc ttccgcgagc 2589841 tgtttggctt tctcagctgc tgcggactgc tcaacagaat aacggtctgc atcggctttt 2589901 ttctttacct ctgagtcgta ttgacgttca cggcgaagaa tttctttttc ttctagttct 2589961 atttgttttt ggcgttcgat aattttaacc tgcatttcct gctctgtgac ttgctggcgc 2590021 gctcgggcag tctctaaatc atatgcttgg tcggcattcg cttttgccgt atcttgttct 2590081 ctgcggaatt cagccatttt gagctgattg attttttcag cttcagcgat ttccgtcgcc 2590141 cgttcaagtt ctgatttttt tgcgtcttta tcggcttctg cccgcttaat tcgggtttct 2590201 ttatcagcct ctgctgttgc gatatcagca tcgcgtttta cttgggcaat tctcggtttc 2590261 cctaatgatt caagataacc gtttttatca cgaacatctt taatggtaaa cgagacgatt 2590321 acaagtccca ttttcgcgag atcctgtgaa gcgacacgct gcacctcttg agagaatttt 2590381 tctctgtttt tatagatttc ttctactgtc attgagccga gaatggaacg aaggtggcct 2590441 tctaaaacct cccgcgcttc ctgctcacgg tcgtcttttg atttccctaa aaattgttcg 2590501 gccgctgtag cgatttctcc tatagaaccg ccgattttaa taatcgcagt tccatcggcc 2590561 attactggca ctccttgttc tgtatagact tcaggtgtcg aaacatcgag tttgcttgat 2590621 aataggctta gcggctctgc ctgctggaag acgggaagga caaaggttcc tccgccgcgg 2590681 acgattttaa tacggttgcc gccttcatcg acatgaacat ttttattacc cagatagctc 2590741 cctgttacaa ttaacgcttc atcaggccct gctgtacgat acttcgtaat aaacacagct 2590801 attagtgcaa ttaataaaaa gaatacaact ccgatgatca ttataatcgg cattgtcata 2590861 tcaaattcct ccttttatgt taaatgggtt catgcggagt aaccgaaaga actccgttgt 2590921 taatatctac gactaacacc gttgtcccgt aactgatctg ctgattatca aaactgaccg 2590981 ctgactttga aatggtcccg cctatccctt ctatgaccac ttcaccaaac ccgtcaaccg 2591041 gcacagctgt aatcacttta ccgagtcttc ctctgagatc atcttctcta tatgccaatg 2591101 attcttctgc agatgataat ggcaccagta caaagatgtg aagcaatacc accagcatga 2591161 tcgaaaggat gcaagataaa agcgcaatca gcaagcttga cagaggcaat acaagttcac 2591221 ctatatatcc gcccgctgaa aaacatgtaa aaaatgagag cactaatgtc ggattaagaa 2591281 acggaatgcc ttctgacagc cctgaaaata catctccgaa aaacaggaat aacagcgtaa 2591341 ggctgcccgc aataataagc gtataaagat acattgtttg tataggtact ccaaataact 2591401 ccaacttcct catcctttct tcatcaatgc attgatgaac ggctgccgtt accatttata 2591461 cgagacacct cgggaaaagt ttcaaaattt taagacaaat aacccatttg aagtgcttta 2591521 taaatgataa ttgcttatat atatggtaat gtcattttag gaggagatat gatgagtatc 2591581 tttaatgaag ccagattaga aacgtggaac gaattgaaag gactttctga cgaaaagctg 2591641 aatcaaaagc cttctgctga agaatggagc atacgggaag ttcttgacca tttgaaaaaa 2591701 atcgatatga ccgcacaaaa aatgttgaag gaacgtgtaa aggacgctcc gattaaagaa 2591761 attgaagaaa aaccgcttga agtagcacag gacagaaata ataaacggaa agccccgagt 2591821 catcttgagc ctgcgcatga ttttatttca ggcagccaaa tgaaacgtga gcttgatgtg 2591881 gtaagagagc agctgactgc tgcgattgcc tctctgaaag aagaagattt tgaaagagtg 2591941 cttccgcatc ctgtgtttca agagctgact gtcagacagt ggatcgattt tatcggccat 2592001 catgaaaaac ggcacctcag ccaaatgaaa gaaattaaag aaaagataga aagggcctga 2592061 tttaatcaga ccctttctgc ttttcgtttg acttttcgct gataggaatg aacttctatt 2592121 tcatcacctg tgtaaacagc accaggtctc tccacaatac agacaatccc tctaatgccc 2592181 agtgcgtggc ggacgaaagc cgacgccagc ttcggttggt ccggataata agactgaatg 2592241 acttctcccg gctggataca cggatcattt tcgccctcac acagcagagc cgctccgctc 2592301 ggaaaaataa tccggcttcc ttcttttaat gaagtaagat ctggcatacc gctgactgcc 2592361 acattcgccc cgagccattc cggcaaaatt ctcggcactc ccatttttaa agcgatttcg 2592421 ttgcattcct ctattgaaac aattgaaatt tgtctgcggt tgaaaatttc agtccctctt 2592481 gaaaacattg gttctctggc tcccgctttt ttggtcaggc caaaatgcaa gtcgccgggg 2592541 atgccgccat aatcaaaatc aagcttgtcc atttgctttg ttacgaagct ttttgtatct 2592601 gcgatatata agccttccgc ttttgcagtc atacgcttcc acatcagctg gcaccttcct 2592661 tcttatctaa aatttccacc tatgcttcat tatcccaaaa aatcccgctc tgtaaaggag 2592721 cgggattttg attataccgt tttaggcgta aggttaaagc agcgtttgta gatccagttg 2592781 tatgcttttt catttaaatc tctagggttt ccgaaggttt gcggatcttt cattgcttct 2592841 ttagacaagc gttcgatcat atcaggtgat actccctgct cttctaaagt cggcacttct 2592901 aaatcttcga ccagatcata catccaattg acagatgctt tcgcagcttc ttctgttgtc 2592961 atcttgcttg tatcaatacc gaacgctttc gcaatacgcg caaacttctc aggatagccc 2593021 ttccagttgt attccatgac agggcccatc atcgccgcta cacattggcc gtgagcgact 2593081 gggataatac cgccaagcgt ttggctcatc gcatgagcag cgcccgctga ttcacttccg 2593141 taagaaagac cggcaagcat cgcagcctgc gccattccgt accttgcttc cagatcctct 2593201 ccatcagcaa atgccctctt gatgtaatga gcggcatact caatcgccat taaggcaacc 2593261 gcatccgtga ttggctgtgc aaatttcatt gtatagcact caatggcatg ggcgagcgca 2593321 tcaattcccg tcatagctgt tacatgcgga ggcattgaaa catgaagctc aggatcaatg 2593381 attgtcaagt gcgctgcaat cagcggaccg cccgtgttga atttgaattc tctttcttca 2593441 tctgtgataa ccgcccattg ggttacttct gatccggttc cagctgtagt gggaattgtc 2593501 gtcagcggag gaatgcggtt ttccagcggt tttttcccat ctgccgcttc ataatcaagc 2593561 acgcttcctt cgtgagtcgc ttctactccg attgcttttg ctgtatccat ggagcttccg 2593621 cctccgactg ccaccaaacc attacagttc tcttttttgt aaagctcaga tccttcattc 2593681 accagacgga caggcgggtt tggctcaact ttattaaaga gtaccacttc aatgcctgct 2593741 tctttaagtg attcgattac gggatcagca acaccggctt tataaatccc agggtctgtg 2593801 acaaggagcg cttttgaaac gcccagtgca gctacttcct cacccgtatg cttgatggct 2593861 ccgattccat gcttaatcac agtcggaatt tcaaatgtgt ggaatttctg catgctttct 2593921 accttcatat ttaatgtcat catcaatctc cccctcttat gaattaaacc agttaaccgc 2593981 tgccggtttt gtattgcggt atacatgttt gacttctgtg tattcttcaa ggcctatttt 2594041 tccaagctcg cgtccgaacc cggattgctt atatccgccc catggcgctt gtgcaaagta 2594101 cggatgaaaa tcgttgatcc aaacggttcc cattctcaag cgggctgcta cccgttcgca 2594161 cttttcaatg tcttttgacc ataccgctcc agccaagcca tagatggtat cattcgcaag 2594221 ctcgattacc tcttcttcag agctgaaggt ttcgactgtc aatacaggac cgaaaacctc 2594281 ttcctgaacg attctcatgt cagaattaca gtttgagaaa atagtaggtt catagaaaaa 2594341 gccgttttga agctcaggat cttccgggcg tttgcctcct gtctccagct tcgcgccttc 2594401 ctctattccg atctctacat atttttctac ctttgccctg tgctccgccg aaataagcgg 2594461 accgctttct gtctcagcat gaaaaccgtt tccgagtttt atgcgttttg cccgtttgac 2594521 cagctccgcc aaaaattgat catgaatggc atcctcaaca agcaagcggg aacctgcaga 2594581 gcatacttgg ccggcgtgga aaaatacagc gtttaaggcc tgatcaaccg caacttctaa 2594641 atccgcgtcc ttgaaaacaa tatttgggtt tttcccgcca agttcaaggg cgattttttt 2594701 gacgtttccg cttgccgccc gcatgatttt tttgcctgtt tcaattccgc ccgtaaatga 2594761 aatcaaatcg acgtctttgt ttacggcaag ctcgtcgccc actgtggctc ccggtccaag 2594821 aacaagattt gcgacacctt ttggaacacc ggcttcttcc atcagcttaa agactttgat 2594881 tgtcgtcagc ggcgtaatct cactcggctt catgacgatt gtgtttcctg cggccagtgc 2594941 aggggcgatt ttccagctcg cttgaaggag cggataattc catggagtga tctggccgca 2595001 aaccccgatt ggctccctaa taattttgct ttctgaatca ggaatcggag atgaaatgat 2595061 ctctccgcca tctttgtctg ccaagccggc gtaatattga aaaacattgg cgatatcgtc 2595121 catatcggcc ttgctttctt cgagtgtttt tcctgtatca agagattcaa gctcagccag 2595181 ctcctcaaga tcgcgtctga ttaattccgc aattttcaga acaatttttc cgcgttcaag 2595241 cccggatagc gatgaccatt ctcctttgtc aaatgctcta cgtgcggctg cgattgcttt 2595301 gatggcgtcc tctcgccctc cctcgcttac agttgcaatt tcttcttgat taaatgggtt 2595361 gataatactg cggatctgtt ctttttcggc actgatccat tctccgtcaa tgaataatgt 2595421 ttgactcata taagcctcct tgacgtaaat aaagtttgtt aaataaaaat ttaatgtttt 2595481 taacaacctt aatctaacat atggttttta aactgtcaaa gtcccatttt gatttttctt 2595541 tttgactttt cctcatgttt cgttaagata aagaacataa agaaataact taacgaattt 2595601 aattttctaa aggaaaagag ggtcagtatg gatgaaaatc cagaatttgc agctatagaa 2595661 caggctcggg atcttgttat tgactccatt gctgaaacga tggatcttta cggaattacc 2595721 cgcagtgtcg ggattttata tgggacgatg tatatgaggg atgagatgac gcttgacgaa 2595781 atgcgtgagg agttgcaaat gagcaaacca agcatgagca ctggcgtcaa aaagcttcaa 2595841 gacttaaatg tagtgaaaaa aacatttcac cggggcatcc gcaagcatac atttgtggct 2595901 gagaaggatt tctttaaatt tttcacaaat ttctttccac ctaaatggga gcgggaggtt 2595961 caagtgaatg taacagcgat cgaggaagct caagctgatt tacaaaaggt tttatgcaag 2596021 gaagatctcg atgaggatat caaaaatgaa gcactgcagt tatatgatca gctggaaagc 2596081 tctaaagctt actatgactg gctgaaacgg cttgctgaat cggtgcagac cggagaaatt 2596141 tttaaattta taccggtcga aacaaagtaa agcagaaaac gcctgggaaa ctaggcgttt 2596201 ttttgatgta actactacaa atttgaaaaa tacgggaaaa acaccccatt tacttccaaa 2596261 atatttgatg gtaattttat gtaggtaaaa tttgtatttg gcctttcaga ggaggtgaaa 2596321 agcgggcagg cctgtttaat ttatcatttt ttagggggaa ttttgttatg aaacgcaaat 2596381 tattatcttc tttggcaatt agtgcattaa gtctcgggtt actcgtttct gcacctacag 2596441 cttctttcgc ggctgaatct acatcaacta aagctcatac tgaatccact atgagaacac 2596501 agtctacagc ttcattgttc gcaacaatca ctggcgccag caaaacggaa tggtctttct 2596561 cagatatcga attgacttac cgtccaaaca cgcttctcag ccttggcgtt atggagttta 2596621 cattgccaag cggatttact gcaaacacga aagacacatt gaacggaaat gccttgcgta 2596681 caacacagat cctcaataac gggaaaacag taagagttcc tttggcactt gatttgttag 2596741 gagctggcga attcaaatta aaactgaata acaaaacact tcctgccgct ggtacatata 2596801 ctttccgtgc ggagaataaa tcattaagca tcggaaataa attttacgca gaagccagca 2596861 ttgacgtggc taagcgcagc actcctccga ctcagccttg cggttgcaac taatgtaaaa 2596921 gaccggttaa cgccggtctt ttttgcgttt taccctcccc tttttctcta atccccgtta 2596981 tcttttttct ggtttaaaat ttaaattgac aaacactaga aacaggagta aattcttgag 2597041 tgttcaattt catacagtct cttttaccgc ttaatcaaac acgaacgggg gaaccaacga 2597101 ttggctgttt tattaacagc cttggggtga atcttactaa gtaagagggg gtactctgaa 2597161 tccctaatcc gacagctaac ctcgtaggcg tatacagaga ggaggtctat tatcggccat 2597221 tctttgcaat ggtctttttt gtttcaaaaa cgttaattca ctaagggaga tatgaacatt 2597281 gggaagaatt aaaaataagc aatttgccgt gatcgggctg ggccggtttg gcggcagcat 2597341 ttgtaaagaa cttcatagaa tggggcatga ggtccttgcg gttgatatca acgaagaaaa 2597401 ggtcaatgca tatgcttctt acgccactca tgcggtaatt gccaacgcca ccgaagaaaa 2597461 cgaattgctt tcattaggaa tacgcaattt tgaatatgtg attgttgcca tcggagcaaa 2597521 tattcaagcg agtacgctga ccaccctatt attaaaggag cttgatattc caaatatttg 2597581 ggtgaaggct caaaactatt atcatcacaa ggtgcttgaa aaaataggcg ctgaccgcat 2597641 tattcatcct gaaaaagata tgggggttaa aatcgcacaa agcctttcag acgaaaatgt 2597701 tttgaattac attgatctat ctgatgaata cagtattgtc gagctgctgg ctacgcgcaa 2597761 gcttgattca aaatcgatta ttgacctgaa tgtaagagca aagtacggct gcacgatcct 2597821 ggccattaaa catcatggag atatctgtct ttcccccgcg cctgaagaca tcattcgcga 2597881 gcaagattgc ctggtgatca tgggccacaa aaaggatatt aaacgttttg aaaacgaagg 2597941 gatgtagaca aaggtgacac ttcaaaagga taaagtgatc aaatgggttc ggtttacacc 2598001 gcctcaagtg cttgccattg gttttttcct taccattatc atcggggctg tcctattaat 2598061 gcttccgatt tccactacga agccattgtc atggatagat gcccttttta ctgcggcttc 2598121 cgctacaact gttacagggc ttgctgttgt cgataccggc actcaattta cggtattcgg 2598181 gcaaacagta attatggggc tgattcagat tggcgggctt ggatttatga catttgcggt 2598241 cttgatcgtc atgatattag gaaaaaaaat cggcttaaaa gaacgaatgc tcgtccagga 2598301 agccttaaac cagccgacaa tcggcggtgt cattggcctt gtcaaagtcc tgtttctgtt 2598361 ttcgatcagt attgaattga tagcagcact cattttatcc atccggcttg tacctcaata 2598421 cggctggtca tccggcttgt ttgcaagttt gtttcacgca atatctgctt ttaacaatgc 2598481 cgggttttcg ttgtggcctg ataatttgat gagctacgtt ggcgatccta cagtgaacct 2598541 cgtgattact ttcttattta ttacaggagg gatcggattt acggttctgt ttgatgtgat 2598601 gaaaaatcgg cgttttaaaa ctttttcttt acatacaaag ctcatgctta caggaacgct 2598661 gatgttgaat gcgatcgcta tgcttacggt ctttatttta gaatacagca accccggcac 2598721 gctcggccac ctgcatatag tggataaact gtgggcctcc tattttcagg cagtgacgcc 2598781 gagaaccgca gggttcaatt ctctagattt tggaagcatg agagaaggaa caattgtatt 2598841 tactttatta ttgatgttta tcggagcagg aagcgcatca acggcgagcg gcattaagct 2598901 gactacgttc atcgtgattt taacatctgt tattgcttac ttgagaggta aaaaagaaac 2598961 ggttattttc cgccgttcca tcaaatatcc gattatcatt aaagctttag ctgtgagcgt 2599021 caccagtttg ttcatcgtgt ttttagggat tttcgccctg acgatcacag aacaagcgcc 2599081 atttcttcaa attgtgtttg aaaccttttc cgcattcgga actgtcggcc ttacgatggg 2599141 gcttactcct gaactgacaa cagctggcaa gtgtatcatc attgtcatca tgtttatcgg 2599201 aagaattggt cctttaacgt tcgtgttttc attcgcaaaa acagagcaat caaatatccg 2599261 ttatcctgat ggcgaagtgt ttacagggtg atatcaaaaa aatccggcgt gcagtcgccg 2599321 gattttttat gattcgatat gagattgatt ttgtcttttt tcctgttccg cgatgatttc 2599381 gttatcctcc gcgttatcac gggtcacttt ttgcgtaaga atcgcaccaa ctgctacaag 2599441 tatcataaca gcgatgtaat aacctttttc attgagttcc agattatcag cattatagag 2599501 tccgatacta aacaaaaata ctcccgcaaa aaaagtaaaa taagctagta ctgtaaaggc 2599561 aaccgtgttt ctgcgtctat atttctgcac ctttgttccc tcccgaaagc atagttaaaa 2599621 agtgataact tccgtggaat attatacctc aaattccccg gaatggaaca aagaattaaa 2599681 aataccagta aaaagggctt aggttgcctc ctttatttca acagctgaat catcaatcca 2599741 gccgataagt ttatcattga tttggaattg gtaccataca gactggcctt tctgtttttt 2599801 agacacaacc tttatgtctt tgccgacgta agattgggca gaggtaagcc ttatggaccg 2599861 atcatcagta gaaggcttgg accatacgtc ttgaacggca ctgtctttaa tagaggcgtt 2599921 taaatccaca gatttgaggg atggatttac ctcatcgtac tcatctaaat cgtatttttc 2599981 cacaatagcg ctgattttgt cagcgtagtc agggtctgta gcatatcctg atgtttgcag 2600041 ggcggttgcc gcttccttat aattccctgc ctcaagcacc ggtttatact tctttttatt 2600101 ccacgatgtg ccacggacga acaattgggc gtgatcatcc atagattcaa aaaacgtgct 2600161 gtattttcga aacttcgcgc gaatggtttt tcttttccct ttttcaactt cgtccgtttc 2600221 catcgtgaca tgatggcctt tataattccc ttttacgcca aaaaggttgt tggccttagc 2600281 agccagttca ctgttccccc agtccgattc gagaatggcc tgagcaattg tgatgctggg 2600341 gagaacatgg tatttttcat acaaaatttg ggcatgtccg gacagactgt ctataaatac 2600401 ttgctgttca tcgatttctt cagtttcttt ggatatttca atcggttttg ataaagttgt 2600461 cgctaaaaca aacagagcta gcggaatcga tacaaggaaa aatagtgaaa tcaagagttt 2600521 acgtttttta agttttttac gggccatgaa aaccttcctt cgaattaaaa gattacgaat 2600581 gtaaaagaat ctacctttta gaattttact tgcacttcta atatttttca attctttagg 2600641 gataaagttg ggaaaagatt gcaaaataaa aaccttttcg ctcaatgaaa aggtttttac 2600701 catgtttcta tttttgtaaa tttctgagtg cattccgata ttccgtatca tttattactt 2600761 tatatgattt gacagttgcc ttcgacaaac cttgtgctga gacggccggt ttttccggag 2600821 ctgttttcgc tttatcatgt ggtttatgtg ccagcttgtg ccccattcca gtggcattca 2600881 tacaaaatga caggcagacg agcagcacgc taaggataaa agaaatgaag aagagatcat 2600941 gataagcagt catcatagaa tcctgtaccg aaccgctttg tctggcagca tcttttttcg 2601001 tgaaaaagcc gatgagaatg ggaactccca tatagacaaa caatcttaaa aactgaacag 2601061 ctgtcattct cttgaccaaa tcaggcagcg ggcctcccat ggcagctccc atcagccctg 2601121 cggcgactgt caggcctgtt cccgctgcaa gcatgataaa cagtgccgcg aacatataaa 2601181 gagatgatcg atcctgtata tgcagccatt gaaaattcac aaaaacgaga atgagtccgc 2601241 cgataatacc gagcatccct ggtccgactt tatcgtataa cagagcgctc aaaatggccg 2601301 cgatcgccac tccgattaaa agagtcaagc ttaaaagaat gagatgctcc tgagaaatat 2601361 catacatttg acggagcaag ccttgaaaag cagaaaggct gacagctacc gttatcgtcc 2601421 ctgcagctat gatcaataag ccgagcaccg gttttggcag cagcatcagt ttaatagata 2601481 tgaaggggtt tttcacttta tattccacaa tcaatagacc aatgagcaaa cataacgtca 2601541 ccccgaaacc aatccataca taacccgatg acagccccca tttttgcaga aaaatgaatg 2601601 aaaccgctga ggctgcggca aggaagacag ataaaagaat tcccgcacga tcaagcggct 2601661 gttcttgatc cgccgctccg tgatgctcat catgaagaaa gaaatagctc accgcgacac 2601721 cgatcaggga caaggtgcca aagatgaaaa acagccatct ccaatgcccg cagcttgttg 2601781 caatggttcc caggattgta ccgatgataa cagaaccata gaatcccccg atcagcacaa 2601841 gcagtgcata gttcctgcgt tcaatcggga atgacagtac aagcattgga atcataatca 2601901 tcagcatgac gcctgttgcc gccccttgta aaaagcgccc tgccgccatc aatgcaatat 2601961 cgcctgaaca tgcgatgagc agtgagccta gtataaagac aggtaatgaa gccagataga 2602021 cgggacgagc accgaatttt ttcctcagca gcggtcctgc cggaactaac aaggcaaagg 2602081 ccatattgcc gatcaatatc ggatttactg atgtaaagac acttgttcca accgttttct 2602141 gaacaaggcc ttgaactgac gacaatgccg tgttagacat caatcccggc ccgaccgcta 2602201 agacggcgag caaagaaatc acccaatagt gttttgtctt catgttgtca tcccttccta 2602261 tatgaataca tgcgaaacac atcatttttt gaaaacaaaa gaagctaata gattttgcat 2602321 accattagct ttcattctaa tattctccct ttcaggggaa atgatattat tttattataa 2602381 ttatgtgaat gaatgagcat ataatcaaat attatttcaa atcgattgtg ttttgtcaat 2602441 ggagtaaatt tcaagcacaa catagaaagc ttgaaagctt ttccccgata ttgtgtctag 2602501 aactgcactt atgaatccct gctcgttccc tcaagcgaat taaagcaggc cgttttaatc 2602561 ctttcaatcc actattccaa ctaataaact caaataagtt ggtgataaga caacatttta 2602621 cccccacatt tttttgtgtt cactgggcgt ttgccgcctc taaattgtat atgggtaaat 2602681 accatgaatt aacctatgaa ataccaatgt aagggaggca aaaacgaatg gaactgtatg 2602741 agtgtatcca agacattttt ggcggcttga aaaatccatc ggttaaagat ttagcaacgt 2602801 ctttaaaaca aattccaaac gcagcaaaat tgagtcaacc gtatattaag gaaccagacc 2602861 agtacgctta cggccgaaat gccatctatc gaaataatga attggaaatt atcgtgatta 2602921 acattccgcc aaacaaggag acaacagtac acgatcatgg tcaatccatt ggttgtgcaa 2602981 tggtgttaga aggaaagctt cttaattcta tttatcgttc aaccggcgaa cacgcagaac 2603041 tctccaattc atactttgtc cacgaaggag aatgccttat ttcaaccaaa ggtttaattc 2603101 acaaaatgtc caatccaaca tctgaacgaa tggtgtctct tcatgtctac tcccctcctt 2603161 tggaagacat gacggtcttt gaggaacaaa aggaggtatt ggaaaattca tgattgacag 2603221 ataaactgct cactttgact tcactcaact ggaggattca gagaatgaaa ccttttcctc 2603281 aaaacaaaaa aacccttatc gaataagggt ttaaaggtat ggagccaagg gggctcgaac 2603341 ccctgacctc tacgctgcca gcgtagcgct ctcccagctg agctatggcc ccgtatgtaa 2603401 cgtcatgttt attatagatg attttatttt gaaaaacaag ctgtttcctc ttgaattgac 2603461 agaaaaaata aggctcggaa aagagcctta tttttcgact tacatcatga tcaaaagtaa 2603521 aatcacaccg agaataattc gatagattgc aaatgggaca agtttgattt tgttaatcag 2603581 ccttaagaag aaacggacga caaacagtgc gaccacaaag gcacagataa agccgacgat 2603641 gaaaaacggc atcagatccg aacttaagct gtcccaatgc ttcacgaggc ttagaaagct 2603701 ggctcccatc atgatcggca tcgccataat aaacgtaaag tcggctgcag ctcggtggtt 2603761 taatccgaga ataacaccgc cggaaatggt tgaacccgaa cgcgagaaac caggccaaag 2603821 ggaaagacat tggaataagc cgacggctat cgcctgttta taggaaatgc ggtcgagtgt 2603881 gtctgtcgct gttttccgtt tattgaccca gtcagcaaaa agcatgagga ttgccccggc 2603941 aattaaaccg atggccacag ttttaacgga aaataaatat tcatcaatgt aatcttcaaa 2604001 caaaaagccg agaacagctg caggcacgag tccgacggca atttgggcaa tgcttaattt 2604061 atgtccctgc tcctggtcgc ttgtaatatt ttttttcaag cccagtaaat ttaaaattcg 2604121 gtctttaaac acgatagcta ctgctaaaat ggagcctagc tgaataacca ccttgaatga 2604181 gttagcagct tcttctgaca tcagattact tgattttagc cagatgtcgt ctactatgat 2604241 catatgtcct gtcgaagaaa ccggcgcgta ctctgttaat ccttctacga ttcctaaaat 2604301 ggcggctaca aacaattccc atagagtcat gattttgatt ctccccatta gacatttatt 2604361 tttttacata acgggagctt cccataaatg gaaagcccgt cttatataac tataaacgaa 2604421 aatcacactt tatgccccgg cgtattttca tttttttctt catcgtataa atgtgactgc 2604481 attttaaacc agtcaaataa atgtgtcgta atgactttgg caaccgcata gccgggaatc 2604541 gcaagaatga ttccaacaac gccaaacagc ttgccggctg ttaacagcag aaaaataatc 2604601 gtaatcggat ggatgtgaag gttttttccc ataatttgcg gagagatcag cttcccttca 2604661 atcagctgaa caatcgtcca aacgatcacc agcttaagca gcatgagcgg cgatgtcact 2604721 atggcaatga taatcgcagg cgtaatggca atcgttggcc ctaaatatgg aacgatgctt 2604781 gtgcaagccg caatgactgc aagcaatgaa gcataatcca gcccgataat caaataaccg 2604841 ataaacagca aaaacccgat acagaagctg acaatgatct ggcctctgat ataagagctt 2604901 aaccgatgat tcatttcgct taagactgta tatgtctgtt ctttcaatcg agtcggcaca 2604961 aacttcagta tgtagaccgg taattttctt ccgtctttta gcaaataaaa tagaataaac 2605021 ggaaccgtga cgatcgaaat gataatctca gtcagtgcgc cgataaaatt cccaacaccg 2605081 gtaaaggtgc tgttcacgat cgtcgctgcc tgatccgaaa cctttgtagc aagatcagat 2605141 atattaatgt tcatcgtttg ctgggcctga ttgacgaagt tgctgccaat cagctgtttc 2605201 gtctgatttt ctacgacgtc cacatatctc gggatattgt caatcaaact cataatttgt 2605261 tcttttaaga agggaatgat cgacacgatc gtgatcgtga tcagcccgat aaccaatagg 2605321 tatagcagca atatagaata gattcttctt attcttcttc tctccagaaa atcgacgact 2605381 gggtttaaca gataaaaaac aatgcctgtc aaaataatcg gaagtgatat cgttttgagc 2605441 agaacaataa tcggggtgaa aataaatgat gtttttgtaa atactagaat atttaaacca 2605501 atcagcagca gcacaagcaa aaataaaaca aacttattat ccaagaagaa tcgcttgaat 2605561 ctgccgctcc atgtttgcaa cgtctccact atcgttcctc cgtcatacat agtttaatta 2605621 aattgtacac tatcgtccct ataatgaaaa ataaaaaccg ttaattgctg gaaaagcttt 2605681 ctcggtttta acattctatt tatatctatc atgtgatttt gttcttttta agctataatt 2605741 tagctatatc atgcaaaagg agcgatacga gtgatacgtt ttgcaataat aggaaccaac 2605801 tggattacag accgctttct tgagtcagca gcggatatcg aagattttca gctgactgct 2605861 gtttattcaa gatcggctga acgcgctggc gagtttgctg ctaaacacaa cgctgcgcat 2605921 gccttctcag accttcagga aatggcggcg agcgattgct ttgatgccgt atacatagcg 2605981 agcccgaacg ctcttcacaa ggaacaagcc gttctcttta tgaaccatgg caagcatgtg 2606041 ctttgtgaga agccgtttgc ttcgaataca aaagaaacag aagagatgat ctcagcggct 2606101 aaggcaaacg gcgttgttct catggaagca atgaagacca ctttcctgcc gaatttcaaa 2606161 gaactgaaaa aacacctgca taaaatcggc actgtccgca gatttaccgc aagctactgc 2606221 cagtattcct cacgatatga cgcgttcaga agcggaactg ttttgaatgc gtttcagcct 2606281 gagctttcca atgggtcatt aatggatatt ggcgtctatt gtatttatcc ggctgttgtg 2606341 ttgtttggcg cgccgaagga tgtaaaagca aacggatatg ctttatcctc cggagtggac 2606401 ggagaaggaa ctgtcattct gtcttacgac gggttcgaag ctgttctgat gcattccaaa 2606461 atctctactt cctatgcccc ggctgaaatc cagggtgaag acgggacgat tgtaatcgat 2606521 acgattcacc ggcctgaacg tgttgaaatc cgctaccggg acggccgcct tgaaaacatc 2606581 gcgatccctg atcctaaacc ggcgatgttc tatgaagcag aagaatttgt cacgcttata 2606641 aaagagaata agctggaatc tgaagaaaat acatttgaac ggtctttgac caccgcaaaa 2606701 attatggaag aagcaagaaa gcaaatgggg attgtatacc ctgctgatca agcgaattca 2606761 tgccagtcag ctttctcaca ttaatcttcc agacgttttt caagctctgc ttttttctct 2606821 tcaaagccag gtttgccgag taacgcaaac atattgactt tatacgcttc tacaccaggc 2606881 tggtcaaacg gattgacgcc aaggaggtaa ccgctcatcg cgcaggcttt ttcgaagaaa 2606941 tatacaaggt atccaaaagt atatgcattc agctcaggaa tgttaacgat taagttcgga 2607001 acatttccgt ctgtatgggc aagcattgta ccttggaatg cttttttgtt aacgaaatca 2607061 acagttttac cggctaaata gttcaagccg tcaagatcgt tatccgcttc ctcaattgtc 2607121 agttcatgtt taggcttctc tacgttcagg accgtttcga ataaatctct gcggccttct 2607181 tgtacatact ggcctaaaga atgaaggtct gttgaatagt tcgctgaaga aggataaatg 2607241 cccttctcat ctttcccttc gctttctccg aacagctgct tccaccattc cgcaaagtat 2607301 tgaagcgccg gttcgtagtt gatgagcatt tcaattgttt tgcccttatt ataaaggaca 2607361 ttgcgaacaa ccgcatattg gtatgctggg ttatcttcca gttcagatgt tgcaaaatct 2607421 ttgctcgcat ccagggcgcc tttcatcatg tcgtcaatgt tgacgccgct gacagcaatc 2607481 ggcaagagac ctacagctgt taaaactgaa taacggccgc cgacatcgtc aggaattacg 2607541 aatgattcaa agccttcttc gttagaaagc gtttttaatg cgccgcgctc tttatcagtt 2607601 gttgcataaa tccgcgcttt cgcttcttct ttaccgtatt tctcttcaag aagcttgcgg 2607661 aaaatacgga aagcgattgc aggttcagtt gtcgtacctg atttagaaat cacattaata 2607721 gagaagtcaa catcttcaag aagatccatg acgtctctca tataagatga actgatgttg 2607781 ttcccgataa aaatgacttg cggattgccg cgttttgctt ttggcaaagt gttataaaac 2607841 gcgtgattca gcgcttcaat cgctgcccgc gctccaagat aagaaccgcc gatgccgaca 2607901 acaagcaaga catcagagtc agatttgatt ttttccgcgc tttttttgat gcgcgcgaat 2607961 tcttctttat cataatgttc agggaggtcc acccagccta gaaaatcgct gcccgcgcct 2608021 gttttctcat ggatattatg gtgtgctgtt tttacaaagt cccgcaggta tgtaagttca 2608081 tgttcgttga agaaagtcaa cgcttttgag tagtcaaagc gtacatgcgt cattgcttgt 2608141 ccctccataa cggtataatg ttttcatctt tcactttata tgaacttatc tgtgaaatca 2608201 agtcaagaag aaagggcgga atgactggat tccgcccttt gggtttatag agacgcgcga 2608261 aggatggcaa gcacgtcatc tttgttcagt ttttggaagt tgccgaagcc gccgtgttcc 2608321 atttccttgg ctgcgatatc agcaatcagc tcaagctttt cttctccaat attgtaatca 2608381 gcaagacgag aaggtgcacc gaggcttgtc cagaacgcag acagtttatc gattccttca 2608441 agcgcaattt ctttatctgt tttgccttca gtatcaatgt caaacatgtt gagcataagg 2608501 tttttaaaac ggcctacatt tgtatcaagc gtgtatctca tccaatttgg gaacagtatt 2608561 gccaaaccgc ccgcgtgcgg aatatcatat acagctgaaa cagcgtgttc cattgtatga 2608621 gaagcccagt caccgaagta tcccatttgg agcgtgccgt ttaaagcaat agtaccagca 2608681 tacaaaatcg tttcacgaag ttcgtagttt tccagatctt caagaagctt aggagctgtt 2608741 tcgatgaccg tctgcaaaac agcaaagcac attctatcct gaagcggcgt gttttcaaca 2608801 ttatggaagt attgttcgaa tacgtggctc atcatgtcaa ccatgccgta tactgtttga 2608861 ttttctggaa cggtgaacgt attttcaggg tctaaaatag agaaacgcgg atgagtgaca 2608921 ttgctgcccc atacaaattt ctcgtttgtt tcccagtttg taatcacgga atcagggttc 2608981 atttcagacc ctgttgcagc aagagttaaa acagtgccaa acggcagcgc atcctccgct 2609041 gttacttttt tgctgaaaat atcccaagcg tcaccgtcat atttgacgcc agctgcgatt 2609101 gcctttgtac agtcaatcac actgcctccg ccgacagcaa gcagaaaatc aatgtcatgc 2609161 tctctgcaaa gtcctatgcc tttttccact gtcgcaagac gcgggtttgg ctctacacct 2609221 gacagctcat gaacaacagc gccctcttct tttaaaatgc ctgtgacttg atcataaagg 2609281 ccgttgcgtt taatgctgcc gcccccgtaa acaagcagta cattcttgcc gtatcgtttg 2609341 aattcttttc ttaattgttc aagctgacct tttccaaaaa tcagctttgt cggattataa 2609401 taagtgaaat tttccatagt aaaacctcca aatgatgctg gtaaaaaaca gattttccat 2609461 tgtaacataa gttgacaaaa aagaaaaagg gaagcagcca aacggctatt tccccttttt 2609521 ttatagtgat gctttcaaaa ttgacagcac atcttctttg ttgagtgatt taaattggcc 2609581 gaatgtaccg ttagccattg ccttgtcagc gattgtgtca agctgctcat cattaatatc 2609641 ataatcagca agacggttcg gagcgccaag acttgtccag aatgcggaca gcttatcgat 2609701 accttcaagg gcaatttctt catccgtttt acctgcttct tcaacatcaa acacgcgaac 2609761 tgcaagctgt ttcatgcggg cagggttttc agacaatgtg tgtctcatcc aattcgggaa 2609821 cagaatcgcc agtccgccgg catgcggaat atcataaacg gctgatactg catgttcaat 2609881 attatgagta gcccaatccc ctcttgcccc catagaaagc atgccgttta atgcgattgt 2609941 tcctgtgtac aggatcgtct cacgcaattc gtaattttcg agatcattga tcagcttagg 2610001 cgctgtttca atgactgtac gcaaaagtga ttcacacatg cggtcctgat acggcgtgtt 2610061 tgatacatga tggaagtatt gttcgaatac gtggctcatc atgtcaacca tcccgtagat 2610121 cgtgtggttt ttaggtacgg tgaatgtatt caccggatca agaatcgaga atttagggaa 2610181 tacgagcggg ctgccccagc cgtatttttc ttttgtttcc cagtttgtaa taacagatcc 2610241 tgagttcatt tctgaaccag ttgcagcgag agtcaatacc gttccgaatg gcaaagcatc 2610301 ttttggctga tgctttttcg taacgatatc ccacgcatca ccatcatact tcgctcctgc 2610361 ggcaatcgct tttgtacagt cgattacgct tccgcctccg acagccagca agaaatcaat 2610421 gttttgttct ttacagatgg caacaccttt attaacagtc gacacacgag gattcggttc 2610481 cacacctgct aattcatgca cggtcgctcc ggctttattc agctgttcaa tcacttgatc 2610541 atacaggccg ctgcgtttaa tgctgccgcc tccgtacaca agcaatacgt tttttccgta 2610601 aggtttgagt tcctccggaa gtctttccac ttcgccgcgc ccgaaaatta atttggtcgg 2610661 attccagtat gtaaagtttt gcatgacatc tcctccttag attttttatt atgcagaatg 2610721 tcctcaccac atgtaaagca atcagctctc accgatcagc ataccagatg gttttatttt 2610781 gcaaggtgct gggaaagaag ctgatataag cgagggcagg ccagcttccc tcatatggag 2610841 aatgcatgta tagattctcc aatatgtcac aatctataac tgttttaata attcatggag 2610901 gaggttgcaa aacatgagta ccattcaaag aatttgtctt gtattaacca tcattggcgc 2610961 cattaactgg ggactgatcg gatttttcca atttgactta gtagcggcta tcttcggcgg 2611021 ccaagggtca gctctttccc gaatcattta cggacttgtc ggaatcgccg gcttaatcaa 2611081 cctcggtctg ctatttaagc caaacgagga aagatcacgt gaagaagcag caaatcctga 2611141 aatgcgatag gatatcaatc acgctgaaat aggattttgc atgaaatcaa aagcaccgaa 2611201 cattcctgtc cggtgctttt ttcatgctta ttttttgata aggtctttgc ggttggacat 2611261 ttcgatccac tcttcaagct tatcttttaa tgtgttgaaa ccttgtggtg tagaagcttc 2611321 ttcgcttact tgagcagctt taggttttct tggtttgctt tcttttttct caggcgcagc 2611381 ttgtgtcgca cgaattgaaa ggctgatttt gcctttttct tcatcaacag caagtacttt 2611441 tacttgtact tcgtcgccaa ctgaaaggtg ctcgttgata tcttttacga aaccgtgagt 2611501 cacttcagaa atgtgtacta aaccttgagt ttcttcatct aatgcaacaa acgcaccata 2611561 cgcttgtaat cctgtaactt taccagtgta aacactgccc acttcaaatt ttgctgccat 2611621 tcataacaac tcctaagtta aattaaatat ctgtttatac gcaatttaaa attatatcac 2611681 acatgtctta tttccgcaaa gaaaactttt ttataaaaaa tcaggtttat gcacagcaaa 2611741 aagggggtaa actgaaaata ccaaaggctt tctagtattc ccccctttta ttggatgcga 2611801 acaaaaggtt cgtatctttt tttatgttgt tttgtgcagg aagcgtttca ttctgactaa 2611861 cgcttcttga agctgttcaa tcgaggttgc gtatgaacaa cggatatatc cctcaccgct 2611921 cggaccaaac acacttccag gaacaactgc cactttttcc tgcgtcagta gctcctcggc 2611981 aaactgttct gaactcattc ccatgctttt gatagatgga aaagcataga aagcgccgcc 2612041 cggatgatga cagctgagac cgatttcatt gagcgattct acaaacagat tccgtcttct 2612101 tcgatagctt tttttcattt tttctacgtc ttccatgccg ttcttcaggc cttcaagggc 2612161 ggcaaactgc gccattgcgg gcgcgcacat catcgcatac tgatgaattt taagcatggc 2612221 atcccgaagc aaggatggtg ccgcggcaaa accgagcctc cagcccgtca ttgcaaatgc 2612281 ttttgaaaag cctgagatga ctaccgtccg ttccttcatt cccggtaatg ccgctatact 2612341 tgtaaattcc tcatcatatg tcagctccgc gtagatctcg tcggctaaga cgatgacatc 2612401 atgttttttg gcaaactcag caatctcatt cagctcttcc ttcgaataaa ccgaacctgt 2612461 cggattcgat ggtgagcaga tgagaatggc ctttgttttt tcagtgactg ccgcttcaaa 2612521 atcagcagcc gttgctttaa atcctttgtc tgccgttgta tgaacgtgaa ccgggatacc 2612581 gcctgccaaa gaaacaagcg catcgtacgc aacaaaacac ggctcaggaa tgatgacttc 2612641 ctcacctgga ttcacaatgg cgcggatcgc aatatccaaa gcctgacttg cccccactgt 2612701 cacaatcagc tcattatctg gcgagtagct aaggtcaaac ctgttgctca aataacggct 2612761 gatttcctcc cgcaatgagt ataaacccgc attggccgtg tatgacgtat atccttgttc 2612821 aagagagaga atgcttgctt cgcggacatt ccatgcggta acaaaatcag gctcgccgac 2612881 gcctaaagaa atgacgcctt ccatcgttgc cgccaaatca aagaatttgc ggatgccgga 2612941 tggttttatt tgttgtacat agtctgataa atacgaagtc atttacggtg acaccacgat 2613001 tcttttgtcg tcgtctcctg tttcaaacac tttgccgtca tgcttgtatt ttttcaggat 2613061 aaaatgggtt gtcgtagata caactgaatc aagcgttgag agtttatccg aaacaaaacg 2613121 cgctacgtca gacatcgaat tgccgcgaat cacgacagac aaatcgtata cgcctgacat 2613181 caggtaaact gattcaacct cttggaatcg gtaaatccgt tccgccactt catcaaaacc 2613241 gacgccccgc ttcggcgtta ctttgacgtc aatcatggcc gtaacgccct catgtccgtc 2613301 gacttttcgc cagtcaatca tagcggaata atcgataata accttttctt tctccagttt 2613361 gtcaataatt gttttcactt catttacagg gatgcccgcc atctttgcga ttgtttctaa 2613421 atcggcgcgg ctgttttcgt ctaaaatttc taatatttct gtttcttttt ctgtcaattt 2613481 catttgattc acacctttgc aatgtcaaga aatctcatga cattatatca cgttttttga 2613541 cgaatgctaa gaaaaaacga ggagaaactt ccgctagaat tgacaatttc agggcataat 2613601 acaaccatca aaaaaaggga gtgacacaga atggaggcgg tttcaccaat aaggcggttt 2613661 acggtcgatg gagtcaatgt atactacgaa cattatcaaa atcccggcag gcaaacgctg 2613721 gtctgcgtac acggtttttt atcatctgca ttcagcttca gaaaagtaat tcctctcctt 2613781 cgggacaagt acgacatcat cgcgcttgat ttgcctcctt tcggccaatc tgaaaaatca 2613841 agaacgttta tctataccta tcaaaacctt gctaagcttg tcattgggat tttggagcac 2613901 ttgcaagtga aacaggctgt gcttgtcggg cattctatgg gcgggcagat atcgctgtct 2613961 gctgctctcc aaaaacctga gcttttttca aaggttgtgc tgctttgcag ttcagggtat 2614021 ttaaaacgtt cacacccgac gattattttc gggacccata tcccgtattt tcatctttac 2614081 atcaaacgct ggctctcgaa agaaggcgtg atgaaaaatt tattaaatgt ggtgcatgac 2614141 aaatcgctga ttgatgagga gatgattgac ggctatggca gaccgtttca ggacgagcag 2614201 attttcaaag ccatgacaag gtttatccgc cacagagaag gagatttaga acccgagcaa 2614261 ttgaagaaaa tgaacaagcc tgctctattg atttggggcg aggaggatcg aattgtccca 2614321 atggagatcg gtaaacggct gcacgcagat ttgcctaatt ccgtgctgta ctcacttggc 2614381 cagaccggac atctggtgcc tgaagaacgg cctgaactta tttctgaaca cattgctgat 2614441 tttatcaaat aacaaaaaaa ccggtgctga accggttttt ttaaggcgtg caggagctgc 2614501 tgtttttaat gaataaaagc tggccagcca cttcccggca gctggcgatc ggcagcgttt 2614561 gttcaaaaga agtttcaaat atttgctgaa tgcttttcgc cagcaagtcg ggatcgtttt 2614621 catcatagac tgcctgcacg acatcaacag cctccgtttc gtaaaactct tctccatatt 2614681 taaacgggtc ccatttggca atgatcttaa tcatttccct gaccgcatga ctttcttcca 2614741 tattcatcac cgcttataat aaaatttgca gttctatctt atcatagtga agcttagaag 2614801 aataaacata catgaggggg taacagaatg aactttgata aacgagaaga acgccttggc 2614861 acccaatcgg tcaaatggga taaaacaggc gaattatttg gcgtgacaga cgccctcccg 2614921 atgtgggtgg cagatatgga ttttcgcgcc ccggaagcga taactgaagc gttaaaagag 2614981 cgtcttgacc acggtatttt tggttataca actccagatc aaaaaacgaa ggatgctgtg 2615041 tgcggatgga tgcaaaacag gcacggctgg aaggtaaatc cggaaagcat cacattcagc 2615101 cccggcgttg taacagcttt gagcatggcg gtacaagctt ttacggagcc gggcgatcaa 2615161 gtagttgttc agcctccagt ttatacgcct ttttaccata tggtggagaa aaacggccgg 2615221 cacattttac ataatccgct gctagaaaaa gacggcgcat atgcaatcga ttttgaagat 2615281 ttggagacaa agcttagtga cccaagcgtt acattgttta ttttatgcaa tcctcataac 2615341 ccttctgggc gttcatggag ccgggaagat ttactgaagc taggcgaatt gtgccttgag 2615401 catggcgtca cagttgtatc ggatgaaatc cattccgatt taatgctgta cggacataaa 2615461 cacacgccgt tcgcttcgct ctctgacgat ttcgctgata tttccgtgac atgtgctgct 2615521 ccaagcaaaa catttaatat cgccggattg caggcttcag cgatcattat tccggatcgc 2615581 ctgaagcgcg ccaagttttc cgcaagcctt cagcgaaatg gtttaggcgg actgaacgcg 2615641 tttgccgtca ctgcaatcga agccgcgtat tcaaaaggcg gaccgtggct tgatgaattg 2615701 atcacttaca ttgagaaaaa catgaacgaa gcggaagcct ttttgagcac cgagctgcca 2615761 aaggtcaaaa tgatgaagcc ggatgcatca tacttgattt ggctcgactt cagcgcttac 2615821 ggcttgtccg atgcagagct tcagcaaaga atgctaaaaa aaggaaaagt tattttagag 2615881 cccgggacga aatacgggcc tggcggagaa ggatttatgc gcctgaacgc cggatgctct 2615941 cttgcaaccc tgcaggacgg cctgcgccgc atcaaagccg cattatcgta aatatagctg 2616001 taaacgcctt tacgtcttca tttgtaaagg cgttcttaat aaaggaattt tatattttac 2616061 ttctaatatt tagtgttata atagattcat attttatacg aaaggatttc acacgaatgg 2616121 aaattctaaa agactatctt ctgcacatct gctttatttt gtttcctatt cttctttacc 2616181 aagtgttttg gcttggaaaa cctgcgattc ttgtgccaaa aataaacagc ggtttggtca 2616241 cgctcttcgc ctgcggcgcc tccgttttat gcattatttt cccgattcat gaaatggact 2616301 acatacaata cggccttcag atgattcccg ttatcatttg tttattttac attagtaccg 2616361 cttccggact tacagtcgcc gcatctgtcc tatgttttga actgcttttt tacgaacctt 2616421 ccgcaatgtt tgttttcact ttgctgcctt ttcttatcat tatcccaatc ttatttcaga 2616481 aaaaatggcc attcatgtcc aaagcgaaaa aactgctgct gtctttattg atcagctgcg 2616541 tggagatttt cctatttttc gcctcaagct ggattctttc cgccttgaat attttaaatt 2616601 ttcaaaaatc aggaattttc gtttacgagg cggcagtctc agggcttttc cgctccagtg 2616661 ttcttctatt aagcatctat attatcgaaa gcatcgccga aaatatcgcc ctgcgttcac 2616721 agcttatcca ttctgaaaaa atgacgattg tgagtgaact ggcagcgagc gtcgcccatg 2616781 aggtcaggaa tccgctgaca gttgtccgcg ggtttgtcca gctgcttttt aatgacgaaa 2616841 ccctacaaaa caagtcgagt gcggattaca aaaagcttgt actgtcagag cttgaccggg 2616901 cgcaaggcat tatcacaaac tatctcgata tggccaaaca gcaattatac gaaaaagagg 2616961 tttttgacct atctgccctt atcaaagaga caagctccct tatggtgtcg tacgccaatt 2617021 acaagtcagt aaccgtcgag gctgaaacag aaccggacct tttgatatac ggagacgcaa 2617081 caaagctgaa gcaggctgtc atcaacctga tgaaaaacag tattgaagcg gttcctcacg 2617141 ggaaggggat gatccacata tcagccaaaa gaaacggcca tacgatcatg attaacatca 2617201 cagacaatgg ggtcgggatg acagaccatc aaatgcaaaa actcggcgaa ccttattatt 2617261 ccttaaaaac gaacggaacg ggactcggcc tcaccgtaac cttttccatt attgaacatc 2617321 atcacgggac catttcattt aacagcagct tccaaaaagg cactacggtg accattaagc 2617381 ttcccgctga tcttcctcac tagcaaatcg attggaactt taatagaata aatgcgaggt 2617441 gatgacagat gagcacgttt gagacaggct ctatcgttaa aggattttac aaaacaggtg 2617501 tatacatagg agaaatcacg gcttgcaggc cgcagcatta tttagtgaaa gtgaaagcgg 2617561 ttcttaccca tcccgctcag ggagaccttc atcatccaaa acaggcggat gtgccatttt 2617621 ttcatgagag aaaagcgctc gcatatggtg aacagaccaa tatcccccac catatggtga 2617681 agccttatga cggtgaagtg ccggattata ccgaatctct gcgggaggcg acagcacaga 2617741 tgagagccaa attgaatgag gatggttcgg agtgggcaaa gcgctccctt cataatctgg 2617801 acattttaga aaaagaatat tttaaccggc cataacccag tctgacaaaa gattgggttt 2617861 tttacgtcgc gcgcttcaac agttcggtta aatcgattct ctcgccgatt gtgggcggtt 2617921 ttggcttttc gagatactgc ttatcctgct caacaagctt aaaaagttta tatgctgtga 2617981 gagcatcatc aagcgcttta tgatgggtgc cggttccgga atctccatac tcttcggcag 2618041 ctttccataa acccgtcaat gtccggtctc caaaaaagtt tttgtattca agcgataaat 2618101 ctctcatttc tcccttaaac gggaaaggga tatggttaaa catacagttt tgcttcagca 2618161 ctttcatatc catgtttccc cacgtaataa ttgtgctgtt tttctcagga tccagctcgt 2618221 ttagtttacg gatgaaatcc tcgaatctca ttccttcgtc tacctgtttt tgggttattt 2618281 ttaaaaatga tttgcagcgt ttcgtaagct tcgggaactt tttcggtcta acatagctag 2618341 aaaacgtctc aaccacttca tcatcaatcg actttacaat tccggcttca atgatttccg 2618401 ggaagaagtt ttgaggactg tactttccat caggcattgt aaattcgaaa tcaataatga 2618461 gtaagctgtt tgtcgtcacc ttttacacct gcctttcctc cgatcagaaa atgctatctt 2618521 tatagtatat caattcccct tctcgacatt tcttcatttt ctaaaaataa tgaattttcc 2618581 cagccgcttc gtttctttta aattgtgaat cgtttcttta taattagtaa ggaacccgaa 2618641 ataataagaa ggtgatgtta tttctatccg taagaaaaac tttgtcattg tgtggctggc 2618701 gaactttttt gtctccgcta gcacaacgat gatcgttcct tttctctcct tatacattga 2618761 gacgctcagc tctttttcaa acggctttgt gcaaaggtgg agcggctatg tgttcggcat 2618821 tacatttctc atggcgtttt tggtatcccc gttttgggga cggttcggag acaaacgcgg 2618881 atacaagaaa atccttatgg caaccggaac aggcattgcc ctcagcattt tcttcatggg 2618941 ctttgttaca tcggtgtacc aattgttttt tctgcgtatg gcaatgggtc ttgtaaccgg 2619001 attcatcccg acatctcttg cgatgatttc ggcacagact ccgaagagct cagctggcaa 2619061 aacactcggc acgctgcaaa tggggcaagt gtccggaagc ttgttcggcc cgcttttggg 2619121 aggcatgctt gctgatcgtt tcggctttac gtataccttt tttatcacat cctttgtgat 2619181 tttctcgtct gttcttctcg tgttatttgg tgtcaaagaa aagcatcttg cagagaaaac 2619241 agccaaacgt acgtcttact cgagaaaaga agtgctctcc tatatttttc accatccggc 2619301 gctgtgggtc atgatgctgt taaccatgct gattcaaaca ggcaatttca gtatccagcc 2619361 cctgctcgct ttatatgtaa atgagctgca cggacctgtc aatcttgcct ttttctccgg 2619421 catggcattt tcagcaacgg ggctcggaag tttgctgctg gctagaaaat ggggtgatct 2619481 gggcgaccgc tacggccacc gccgcatttt aatcggactt ttgctcgccg cctctttctt 2619541 ttttattccg caggcgctcg cgtcctcact cagcgtgctc cttgttttca gatttttatt 2619601 cggaatggcg atgggcggtt tgctgccatg cattacggca gcgatccgcg ttcaggctcc 2619661 cggcagcatt caaggtgaag ttctcggcta caatgtcagc tttcgctttt taggaaacgt 2619721 gctcgggcct ctgctcggcg gaatcatatc gagccatttt accatttcgg ccacctttta 2619781 cgtcacggcg tttctctttt tcgccggcgc ctgcatgctt tggatcatgc agaaacttcg 2619841 gaaagattct tatgccaaag caagctgatt ccgagaaaaa actaaggaat cttctaaatt 2619901 taaccttctc gtaatctcaa aagaatggta cgatatggct agaatttagg agaaaagaga 2619961 gtgaccatgt tacgaaaaat aatcggatgg attttgctcc tttgcataat cccattgttt 2620021 gcatttacag ttatcgcttc cggaaaagaa gtaaaacaaa tgaagtccct ggatcaggtg 2620081 cttgataaaa atattgatct gaaagatatc agccttgttc agaacagcta catgtatgac 2620141 agggacggct cccttgtctc ggaaatcgtc agcgaccacg aaaaccgtgt gctcgttcca 2620201 tttaacaaga ttcccgagga agtcaaacag attttcttaa catctgagga ccgccatttt 2620261 tacgagcata aaggctttga ctttatggga atggtgcggg ctactgcttc taacgtaaaa 2620321 gacaagaaaa ttgaccaggg tgccagcacc atcacacagc agctttcaag aaacttgtat 2620381 ttgagccacg aacgctcctt cagccgcaag ctgacagagc tcgcgtattc ctatcagctg 2620441 gagaaaaaat atacgaaaaa tgaaattctt gaagcttact taaataccat ttatttcaac 2620501 aacggtgttt acggcgtcgg ttcagcagct caattctatt tcagcaaacc gctgaaatct 2620561 ctcacagtgg gagaaatggc ttttatctgt gctataccta ataaccctac attatatgat 2620621 cctctcaagc attttgacta cacgaaaagc cgtcaagaac gtttacttaa agggctaaaa 2620681 gatgccgggg tcattacgga caaagagctg aaaaaagccg taaaacaaaa aatcaaactg 2620741 gatgttgaaa aaagagaaga caaatatcct gactacgttt cctacgtcaa tgatgaattc 2620801 actcagctgg tgtctgaatc agaaggcttt gataaacgcc ttcaaaaagc atcaggaaaa 2620861 caaaaagaaa agatcgagaa cgagctgtcc gcaagagtca gcacgctgat gaaagacgga 2620921 gtgaaaattt atactgcact tgatccgtac atgcaaaatc aagttgtggc acaaatgaat 2620981 tccaagctcc cgtatgcgga cgtacagggc ggagcggctg tgattaatca ccagacgcat 2621041 caaatcattg ctctatccgg cgggaaaaac tatcaaaaat atgactttaa ccgcgcctac 2621101 caggcgtaca ggcagccggg ttcatccatt aagccgcttc ttgattacgg cccttatatt 2621161 gaacagaccg gcgcgacaac aagcagcacc attgatgcca gcaagttttg cagcaaagac 2621221 tactgtccgc aaaactacaa taaccgcact tacggcacag tgacgcttga tacggcgttt 2621281 aaaaattcat ataatacccc ggctattaga atgctcgacc gcgtcggcat ccaaaaggca 2621341 ttcagttata ttgagccgta tcattttgcc aaacttgtcg acagtgacta tcttcttccg 2621401 gcggcgcttg gcggatttac aaacggcatg acgcctcttg agatgacaaa ggcttatacg 2621461 acattcggaa acagcggaag ctatacgccg agccatgcga ttacaaaggt gacagacctt 2621521 aaaggaaaaa cactttataa atggaatgat aaagcgactc aaatattcag cgtccgcacg 2621581 aacatgcagc tgaaaaaact gatgtcttcc gttgtgaaaa gcggaacagg gaaaaaagca 2621641 tatttcaatg cgccttacat cggcggtaaa accggaacat caaatgatta tcacgatatg 2621701 tggtttgtcg gcctgactga tacgtataca atgggtgtct gggtcggaaa ggatacaccg 2621761 accagcgttg aatatcttca cagcatcagc cctcagcttt ccatctggaa aggaacgctg 2621821 caagcggctt attaaaggat cggaggggat atggagtgac ttcagaacaa attccaaatc 2621881 gcgttttgct gtttgacggt gtctgcaatt tatgcaatgg cgccgtgcag tttatcatta 2621941 aacgtgatcc ggacggattg atttctttca catcgctgca gtcggaaaca ggacagagcc 2622001 tgctgaaaaa aagcgggctt ccgactgatc ggtttgacag ctttgtcttt attgaagacg 2622061 gccaagtgta cacaaagtca actgcagcca ttaaggtttt caggcatctg cgaggcccat 2622121 ggcggctctt cgtccttttt ttcgcagtgc cgaagcctgt cagagatatg gtctattctt 2622181 tcattgccaa aaaccgctat aagtggtttg gcaaaaaaaa tgaatgtatg ctcccctccc 2622241 cttccattaa aaaaagattt ttaccgtaaa taaaaaatgg ctaggaagct agccatcaca 2622301 gattgttgac aaaatcctaa aacggcttcg ttttaggatt ttgtcatcta ttcagcgtga 2622361 ttgaaaactt ttgaagttgt gaaacggcgg aaacctgaga atctagccgc cgtttcattg 2622421 cgtacagagc acgaagcgca aatctgacca ccaaacgctg aaatggctag cttacacagg 2622481 taagctagcc attatgctat tataaagctt gataaatatg aacagaatac cgataacaaa 2622541 ggtaaaccaa aacagcagtt ccaatagaat gaatccaact aatgacatga gagaaagcgt 2622601 cgaataaatc cggtatacgg taaacacaaa gtaagcgagc gtgacgaccg caaaccagat 2622661 cacaatccaa atgacatttt gcaagagcac aaaggataaa atcccgccgc ccaaataaat 2622721 catggaaccc attctgagtt ttttcaggtt gttcccttcc ggatcattag caaaaaacag 2622781 caatgacagc tcggtcacgg tatttgcaat taatttcaga gcggacagaa ccataaaata 2622841 taaaagtgca aaggcagcaa ataacgcaag cctgattcct ttctctgaaa aataatcgag 2622901 cattccatca tacattccaa atgaagacag catcttcaac gcataaagtg aagttgagat 2622961 ggataaggac gaactaaaaa gcaggatcgc aatcagcgga aaatatcctg tcaaataagt 2623021 atttttcata taaaaaagtc cctttctata atctacctca tttattatgg aggacttaaa 2623081 acacattgac aagataaatt attccatttt ttctcctttt tacgaattac gggcccaaat 2623141 cttcacaaag cagcattttg agagtaaagt agtacgcagg aatcataaaa cgtaaggaag 2623201 ttttatatga aaaaaacatt aaaactgcaa accagactca ccatatttgt ttgtatcgtt 2623261 gtattaatcg cattgctcat tacgtttttt acagtcggtg cccaaaccac caaacgaatt 2623321 agagatcagg aaaaggccac tgcgctgcag actgctgaaa tggtagctga agcgccgatg 2623381 acagccgctg ctttagaaag cggaaaaaaa caaaaggaac tgcagagcta cacaaagcgg 2623441 gttcagaaaa ttaccggcac ggaatttgtt gtcgtcatgg atatgaacgg tatccgcaaa 2623501 actcatcctg acccgagcaa aatcggaaaa aaattcagag gcggtgatga gtccgaggta 2623561 ttaaaagggc atgtccatat cagcacagcc tctggcacgc tcgggaaatc gcagagagcg 2623621 ttcgtccctg tctacgcgga gaatggaaaa caggtcggtg cagtcgcggt cggcatcacc 2623681 gtaaatgaaa ttgatgaagt gatcagccat agcttacggc cgctttactt tattatttgc 2623741 gtcagcatct tcgtcggtgt gatcggagcc gttatcgtcg cccgtacagt gaaaaatatc 2623801 atgtacggac ttgaacctta tgaaattgcg actctgcttg aagaacggag cgcgatgctg 2623861 gaatcgacga aggaaggaat actcgctgtc gatgaacatg gcaaaattaa acttgccaac 2623921 gcggaagcaa aacgcctatt cgtcaaaatg ggcatcaaca caaatcccat tgatcaggat 2623981 gtagatgaca tcttgccgaa aagccgcttg aaaaaggtca ttgagacaaa aaaacctctt 2624041 caagacagag acgtccgcat taacgggctg gagcttgtgt ttaatgaagt tcctatccag 2624101 ctgaaaggac aaactgtcgg agcgattgca acattccgcg acaagaccga ggtaaaacat 2624161 ttagctgaac agctttccgg tgttaaaatg tatgcaaacg cactgagagc gcagtctcat 2624221 gaatttatga acaaactgca tgtgatatta ggtctcgtcc agctgaaaga gtatgatgat 2624281 cttggagatt atattaaaga tatagccata cagcaaaaat cagaaacaag tgaaattata 2624341 aatgatgtca aaagctccgt actggccggt tttctgcttg gaaagcaaag ctttatacgt 2624401 gagcagggcg caaatcttga tattgaatgc aacggtgtca tcccgaacgc ggcagaccct 2624461 tctgtcatcc atgaacttat tacaatcatc ggaaatctca tcaacaatgg cttagatgcc 2624521 gttgccgata tgccgaaaaa acaaatcacc atgtccatgc gcttccataa cagcatactt 2624581 gatattgaaa ttaccgatac tggagcaggc atgtctgaag aagaccaagc caaagtattt 2624641 gaacaaggct attcaacaaa gggcaaaaac cggggattcg gcctttattt cacacagcaa 2624701 agcatcgaaa atttaaaagg ccaaatgatc ctcacaagcg aaaagaatga aggaacgaca 2624761 ttcagtattc gcatcccgta cgaaccgaag gaggaaaatc atgattaatg tactaatagt 2624821 tgaagatgac cccatggtgg gtgaattaaa taaacgatac ttaagccaaa tagatggctt 2624881 tcagctgaaa ggcatcgctt cttcctttca aagcgctctg catattttag gggagcacca 2624941 tattgacctc attttgcttg atatttatat gccgggaaaa aacgggctgg aactgctgac 2625001 ggaattgaga gcccaaaatg aagcggttga cgtgattgtc atctcagcgg ccagcgagct 2625061 tgacgtgatc aagaaaacac ttcggtacgg agctgttgat tatttaatca aaccgtttga 2625121 atttgaacga ttccaaacgg ctctgtctga ttacagacga aaacaaaagg tgtattcaac 2625181 ccatcgcaac atgagccaaa aagaactgga cgccgagctt tttcaaaaga aagaagcaac 2625241 agaaaaagtg cagcttccta aaggcctgac aaaaagcacg ctgaagctga tctggtccag 2625301 tatccagtca tttgaaaatg aatcttttac gacagaagac ttggcaaagc acacagaaat 2625361 ctctcaagta tccatacgaa aatacttaaa gtttcttgaa gatatacagg ttctgaatgt 2625421 agaaatggcg tacggaacga tcggaagacc tgtgtttcag tacaacgtca acaacagtaa 2625481 cattaacgga ataaagcaat atctataaga aaacgcactg cttgctttga gcagtgcgtt 2625541 tttctgtcat atctcttgcc aagatgcttg attctattgt tgataagtta tacaagaata 2625601 acaaagggct ttcacatttt taagcaaata attctaaaaa tagataattt ttaaaaaatt 2625661 atgcgaaatt ctatttattt cttattagtt aaatgataaa ttatgattgg ttagttgatc 2625721 ccgaaaaact aagtcataag tcttacttca gaaaacgatg tcacggtttt ccgcccggaa 2625781 cgccttccgc atccttctct tccccgcctt tcgaaggaaa tactcacacc acgcttattc 2625841 agggaagaat agaactgtct cagcgcattc catttgttat tatcagaaaa ttttatcgat 2625901 tctaagaaat tgttcaggac agcccatcac atgactggcc ggatcagctt tgaaccaaat 2625961 ttttctgggg ggttatatct tgaataaacg aaaaatcgga ttggcgatgt cacttgtgat 2626021 cgcagcaggc accatattag gagcatgcgg aaacagcgaa aaaagcagcg gctcaggcga 2626081 aggcaaaaac aaattcagtg tggcgatggt tactgacgta ggcggagtgg atgacaaatc 2626141 cttcaaccaa tcagcctggg aaggcatcca agcctttggg aaagagaatg ggctgaaaaa 2626201 aggcaaaaac ggttacgact atcttcaatc caaatctgat gcagactata caacgaactt 2626261 aaataaattg gcgcgtgaga attttgactt aatttacggc gtcggctact taatggagga 2626321 ttcaatcagc gaaattgctg accagcgtaa aaatacaaac tttgcgatta tagatgctgt 2626381 tgtcgataaa gacaacgtcg caagtattac gtttaaagag caggaaggct catttctcgt 2626441 cggagtggcc gcagccctat caagcaaatc aggaaaaatc ggctttgtag gcggcatgga 2626501 atcagagttg atcaaaaaat tcgaggtcgg cttccgtgcc ggcgtgcaag cagttaaccc 2626561 taaagccgtt gtagaagtga aatacgcagg gggtttcgat aaagccgatg tcggtaaagc 2626621 aaccgccgaa agcatgtata aatcaggcgt agatgttatt tatcactctg cgggcgccac 2626681 tggcacaggc gtctttactg aagcgaaaaa cctgaaaaaa gaagatccaa aacgcgatgt 2626741 ctgggtcatc ggtgtcgata aagaccaata cgcagaaggc caggtagaag gaacagatga 2626801 taacgtcacc ctcacttcca tggtgaaaaa agtagataca gtcgttgaag atgtaacgaa 2626861 aaaagcgagt gacggaaagt tcccgggcgg cgaaacactt acctacgggc ttgatcaaga 2626921 cggagtcggc atttctccat ctaaacaaaa tctatcggat gatgtgatca aagcggtcga 2626981 taaatggaag aaaaaaatca tcgacggatt ggaaatcccg gcaactgaga aagagctgaa 2627041 aaccttcaaa gctgaataag aatcgcaggg ataaggaggt cgagccctta tcccttgttt 2627101 ttcttttatt ttgaaataaa ggagcggtca atcaatggaa tatgtcattg aaatgctcaa 2627161 tatccgcaag gcgtttccag gtatcgtcgc caatgacaat atcaatcttc aagtcaaaaa 2627221 aggcgaaata cacgcgttgc tcggtgaaaa cggagcgggg aaatcaacat tgatgaatgt 2627281 ccttttcggg ctgtatcagc cggagcgggg tgaaattcgg gtgcgcggcg agaaggtgca 2627341 catcaacagc ccgaacaaag cgaatgacct tggaattgga atggtgcacc agcactttat 2627401 gcttgttgac acctttacag ttgctgaaaa tattattctc gggaaggagc caaagaagtt 2627461 tggcagaatt gaccggaagc gtgctggcca agaggtgcag gacatttccg atcgatacgg 2627521 cctgcagatc catcctgaag caaaagcagc tgacatatca gtcggtatgc agcagcgcgc 2627581 agaaatatta aaaaccctct accgcggtgc cgacattctg atttttgatg aaccgacggc 2627641 tgttttgacg cctcatgaaa ttaaggaact gatgcaaatt atgaagaacc tggtcaaaga 2627701 agggaagtcc atcatcttaa tcacccataa gctgaaagag attatggaga tttgtgaccg 2627761 cgttacggtt atccgtaaag gaaaaggcat caaaaccctt gatgtccgtg atacaaacca 2627821 agacgaactc gccagtctaa tggtcggccg tgaggtatcg ttcaaaactg aaaagagagc 2627881 tgctcagccg ggagcggaag tgcttgcgat tgacggcata actgtaaagg atacccgcgg 2627941 aatagagaca gtcagagatt tgtctctttc tgtcaaagcg ggagaaatag tcggcatagc 2628001 aggcgtcgac ggaaacgggc aatctgagct gatcgaagcg gtgacaggac tccgcaaaac 2628061 agattcagga acaatcacct taaacggaaa acagatccaa aacctgacgc caagaaaaat 2628121 cactgaatcc gggatcgggc atattcctca ggatcgccat aaacacggtc tcgtccttga 2628181 ttttccaatc ggagagaata tcctgctgca aagctattac aaaaagccgt attcagcatt 2628241 gggcgtttta cataaaggcg aaatgtacaa aaaagcacgc agcctgatca ctgagtacga 2628301 tgtcagaacg ccggatgaat atacacacgc tcgggcattg tcaggcggaa accagcaaaa 2628361 agcgattatc gggcgggaaa tagaccgaaa tcctgattta ttaattgccg cccagccgac 2628421 tcgcggcctt gatgtcggag cgattgaatt tgtccataaa aagctcattg agcagcgtga 2628481 tgccgggaaa gccgttcttc tcctctcgtt tgagcttgaa gaaattatga atctcagtga 2628541 cagaatcgcc gttatttttg aaggacgcat tatcgccagc gttaatccgc aggaaaccac 2628601 tgaacaggag cttggtctct tgatggcagg aagcacgcaa aaggaagcgg ggaaagcaaa 2628661 tggttaaacg actctctcat ttactcgtgc cgctcatcgc aatcatactt ggtcttgcgg 2628721 ccggcgcgtt gattatgctt gtgagcggct acagtgtggc tagcggatat tcggctttgt 2628781 ggaatgggat attcggagaa atctattatg tcggagaaac aatccggcaa attacgcctt 2628841 atattttatc cggattggct gtcgcctttg cattccgaac cggactcttt aatatcggcg 2628901 tcgagggaca gctgctcgtc ggctggacag cagcggtttg ggtcggtacg gcgtttgacg 2628961 gaccggcata tattcacttg ccgctcgcat tgattacagc ggcagctgca ggaggattat 2629021 gggggtttat tcccggcatt ttgaaagcgc gattttacgt tcatgaagtc attgtcacca 2629081 ttatgatgaa ttatatcgcg ctgcacatga ccaattacat catttcaaac gtcttgacag 2629141 atcatcagga caagacgggg aaaattcacg aatccgcctc cctccgctct ccttttcttg 2629201 aacagatcac cgattactca cggctgcatt tgggaatcat cgttgccctt ctcgcagcag 2629261 ttatcatgtg gtttatcatc aacaaatcta caaaaggatt tgagctccgg gcggtcgggt 2629321 ttaaccagca cgcttcccag tatgccggca tgagcgtgcg gaagaatatc atgacctcca 2629381 tgcttatctc cggcgctttt gcaggtcttg ccggagccat ggagggccta gggacattcg 2629441 aatacgcagc agtgaaaggc gcatttaccg gcgtaggctt tgacggtatc gctgtcgctc 2629501 ttctcggggg aaacacagcc gtaggcgttg tactggcagc atgcctgctt ggcgggctga 2629561 aaatcggcgc attaaatatg ccgattgaat caggcgttcc atcagaggtc gttgatattg 2629621 tgattgccat tattattcta tttgtggctt caagctatgc gattcgtttc gtcatgggca 2629681 aattgaagaa aaagggggcg aactaagtgg acattgtgca gattttatct atcattgtcc 2629741 ctgccacact cgtctatgcg gccccgctta ttttaactgc tctcggcggc gtgttttccg 2629801 agagatcagg tgtggtgaat atcggcctag aaggcctcat gattatcggg gcgttcacca 2629861 gcgtgttatt taatttattt tttggtcagg aattaggtgc cgccgcacct tggctttcgc 2629921 tccttgccgc catggcagca ggcgccctgt tttcactgat tcacgcggca gcggcgattt 2629981 cgtttcgcgc cgaccagaca gtcagcggtg tcgccattaa catgctggcg cttggggcaa 2630041 ctttatttat cgtcaaactg atctacggca aagcgcagac agacaaaatt ccagagcctt 2630101 tttataagac gaaaatcccc ggtttgggcg atattcccgt cttgggaaag atcttctttt 2630161 cggatgtcta ttatacgtct attcttgcaa tagcacttgc ctttatttcc tggtttatct 2630221 tgttcaaaac gccgttcggc cttcgtatcc gttctgtcgg cgagcatccg atggcggccg 2630281 atacgatggg aatcaacgta tataaaatgc gctacatcgg cgtgatgatc agcggattgt 2630341 tcggcggtct cggcggcggc gtatatgcct ccacaattgc gcttgatttc acgcactcta 2630401 ccatctccgg gcaaggtttt atcgccctgg cagcgcttgt attcggaaaa tggcatccga 2630461 tcggagcact gggggccgcc ctgtttttcg gattcgccca aagcttaagc atcattggat 2630521 cgctgctccc tctttttaaa gacataccaa atgtgtatat gctgatggct ccttatatct 2630581 taacgattct cgctttaacc ggctttatcg ggcgggcaga tgcgccaaaa gccaatggcg 2630641 tgccttatat taaaggaaaa agataaacat tctcccctgg gaagacgatt ctcagggatt 2630701 tttttctaat ccaaaagacc cccttaattt aattgtttat tagtttttta acttaaaaaa 2630761 atatgaagtg ttaacgcttt cttgtagact gtaacaaaca atacatgggg gtgtatgaca 2630821 tgggagcaat tccaaaaacg gggacaattt cacctgagca aaaagactca caggagaaaa 2630881 acctgtttca aaaaatttgg tcttgggaaa tcggtgtgat tcctttgcca ttatacacag 2630941 tattagctgt tattattatt cttgcagcat attacaatga gctgccggca aatatgcttg 2631001 gcgggtttgc catcattatg attcttggtg tgtttctcgg agacataggc caacgcatac 2631061 cgatattgaa ggatattggc ggccctgcta ttttatcttt gtttgttcct tcatttttag 2631121 tcttttacaa tgtactgaat tcaacatctt tagacgctgt aaccaacttg atgaaaacgt 2631181 ctaacttcct ttatttctat atcgcttgcc ttgttgtggg aagtatcctc ggtatgaaca 2631241 gaattgtttt aatacagggg tttatcagaa tgttcgttcc actggttgca ggaacgatcg 2631301 cggccgttgc agccggcatc cttgtcggat ttatttttgg ctatagtgcc tatgattcct 2631361 ttttctttgt tgttgtcccg attattgccg ggggaatagg tgaagggatt ttgccgcttt 2631421 caatcgccta ttcacaaata ctgggctcat ccgccgatgt atttgtgtct cagctggtgc 2631481 cagccgcaat tataggaaac gtttttgcta tcatatgtgc agccttaatg aaaaagcttg 2631541 gcgacaagcg tccagatcta aatgggaacg gacgtctcgt aaaatctaaa aaagcaaatg 2631601 agattttcaa tcaaaaagaa gccgaagcaa aaattgattt taaactaatg ggagcaggag 2631661 ttctgctcgc gtgtacattc tttatttttg gcgggttatt ggagaaattc atcttcatcc 2631721 cgggcgcgat cttaatgatt atttcagctg cggctgtcaa gtatgcaaat attcttccga 2631781 aaaaaatgga agaaggcgct taccagcttt ataagtttat ttcttcaagc tttacatggc 2631841 cgctgatggt cggtctcggc atcctcttta ttccgttgga tgacgtagcg tctgtgattt 2631901 ctataccgtt tgtcatcatc tgtatttcag ttgttatcgc gatgattggt tctggatatt 2631961 tcgtaggcaa gctgatgaac atgtatccgg ttgaatccgc aatcgttacc tgctgccaca 2632021 gcggtctcgg cggaacgggt gatgttgcca ttttatcggc atcaggaaga atgggcctta 2632081 tgccgtttgc ccaaatttca acccgtctcg gcggtgcagg cacagttatt tgcgcgacag 2632141 tgctgcttcg ttttttcact tcataaacag aaagagttcc gttttatgcg gaactctttt 2632201 tttatttatt cacaatccga atatactctc ggggaccaaa cggcagatcc tttgattccg 2632261 tctcactcat tctggctgac aggtggtgct ccagtaaata cagctcccac tcatcacaag 2632321 ccgccacacc gctgcgcccg tcatattgat tcaacatgaa tgcccctgca aatactgagc 2632381 agaataaacc tgagcacatc acgacttttg ttttcacatg accagctcct ttccttcagc 2632441 ttgatcagga ttgattttaa atatacaaat aacctctttt ttgttagact tattttgagg 2632501 tcaaaagaac tcataaaaat ccattacagc agttcgaagc gtggcagctt gcagaaaagt 2632561 gcgatataat ttggactagg tcgtttgacc gtatatttta tacatagcgc atttttcaat 2632621 tgagaacgag aaaaggaggt cttatctttg cagctcttac atcttgctat tttatcgcct 2632681 tttttatttg cttttatcat tcccttcttg gcaaaatacg caaaaagagt gcatacgggc 2632741 tggtttgtgt tgatcctgcc cgtcttgctg tttatatact ttctcccaat gatcaggatg 2632801 acgcaatctg gagaaacact tcgatcggta ttagagtgga ttccgtcact cggcattaac 2632861 tttaccgttt atatagacgg cctcgggtta ttattcgctt tactgatcac aggcattggc 2632921 tctttggtca ctctttacag cattttttat ttatcgaaag aaaaagaaca gcttgggccc 2632981 ttttatgtct acttattgat gttcatgggc gccatgctcg gcgtcgttct agtagacaat 2633041 gtcatggttc tctacatgtt ctgggagctt acaagccttt catccttttt gctgatcggc 2633101 tattggtata agcgggaaaa gtcgcgctat ggcgcagcca aatcactttt gattacggtc 2633161 agcggcgggc tgtgcatgct cggcggattt attctccttt atttgataac ggattccttc 2633221 agtattcgag agatggttca ccaggttcaa ttaattgccg gccacgaatt gtttatcccg 2633281 gctatgattc tcattttatt aggggctttt acgaaatcgg cgcaatttcc tttttacatc 2633341 tggctccctg acgcgatgga agctccgacg cctgtcagcg cttatctcca ttcagctact 2633401 atggtaaaag ccggcattta tgtgattgcg agattcagtc ctattttcgc cttttcagct 2633461 cagtggtttt ggatcgtgtc cctcgtcggc ctctttacga tggtttgggg ttcattccat 2633521 gccgtgaaac aaactgattt aaaatcgatt ttggcgtttt caaccgtcag ccagctcggc 2633581 atgatcatct ccatgctcgg agtcagtgct gcggcccttc attacggaca tacagaatat 2633641 tatacagttg ccgctatggc tgccattttc catttgatca accacgcaac ctttaaagga 2633701 agcttgttta tggcagtcgg gattatcgat cacgaaacag gcacacggga tatccggaag 2633761 ctaggcggcc tgatggcgat tatgccgatt acttttacca tttccttaat cgggacattt 2633821 tcaatggccg gcctaccgcc gtttaacgga tttttgagta aagaaatgtt tttcacaagc 2633881 atgcttcgcg tgacacattt tgacctgttc aacgtgcaga catggggcgt tctgttccct 2633941 cttttcgcct ggatcggaag tgtatttacg tttatctaca gcatgaaatt gctgtttaaa 2634001 acattcagag gaaattacca gcctgaacag cttgaaaaac aggctcacga agcgcctgtc 2634061 ggtatgctcg ttccaccggt cattcttgtc gctttggctg tcagtctctt ctttttcccg 2634121 aatatattgt cgtacagcct gatagagcct gcgatgaact caatctatcc gacactgctt 2634181 gacggccatg agaaattcca cgttcacatt tcacagtggc atggggttac aacggaattg 2634241 ctcatgactg cgggtattgt tgtgatcgga acaattggtt atttgtcgct gaataagtgg 2634301 aaaggaatct ataaactgtt tccttcgaaa ctcacactca accggttata cgataagctt 2634361 ttgactatga tggagaaagg ctcttaccgg gtcacaaaac aatatatgac cgggttttta 2634421 agagattatt tgctgtatat cttcgctggt ttcatcattc tgataggcgg agcttttgcc 2634481 attaaaggcg gattttcatt taaaacggaa ggcatggcta aaatcggtgt atacgaaatc 2634541 attttgacgc ttgtcatgat cagcgccaca gtggcgactg tttttgctag gtcaagactg 2634601 acggcgatca ttgcactcgg tgttgtcggt tatacgcttg cattgttttt tgtcattttc 2634661 agagcgccgg acttggcatt gactcagctc gtcattgaaa cgatttctgt ggcactgttt 2634721 ctgctttgct tctaccattt gccgaaactg aggctgaaaa caaaaacgag aacgttccgg 2634781 atgacgaatt ttatcatttc tttaggcgtc ggtgttatcg ttacactgct cggcatcgca 2634841 tcctcaagcc agcggacaaa agacagcatt gcgtccttct ttgtcaaaca cagccacgat 2634901 ctcggcggag gggataatgt cgtcaatgtc attctcgttg atttcagggg atttgataca 2634961 atgtttgaaa ttacggtatt aacgatagcc gctctcggca tttacagcat gattaaaaca 2635021 aaagtaaaag aggaggggaa aagcggtgaa tgaacaaaaa acaaatgact tgattcttca 2635081 aaccgcgaca aagcttgtat cctttatcat tttgcttttc tctttctatt tatttttatc 2635141 agggcataac gcgcccggag gaggctttgt cggcggactg atcacgtcct cttccatcgt 2635201 tctcttgctc ttggcatatg atttaaaaac cgtgcgttcc cttttgcctg tcaatttcat 2635261 ttatgtcgcg ggagccggcc ttctgctcgc tgtattaaca ggcgttggct cctttgtctt 2635321 cggggctcct tttttaaccc acacattcgg atactttcag ctgccgatcc ttgggaaaac 2635381 ggagctcgcc acagcgacga tatttgattt aggcgtttat cttgttgtcg taggcataac 2635441 gatgaccatt attcaaacga ttggagagga agaataatgg aaatcttaat ggctgtatta 2635501 gccggtatta tttttatggc tgctacgtat ttgctgctgt ctaaaagcct gcttcgcgtc 2635561 attatcggaa cagcactgtt aagccatggc gttcatttaa tgcttttgac tatgggagga 2635621 ttaaagaaag gcgccgctcc gattttgagc gagcatgcca aatcatttgt cgatccgctt 2635681 ccgcaagccc tgattttgac cgcaattgtc atttcttttg gcgttacgtc attcatcctc 2635741 gtcatggcct ttcgcgctta tcaggaattg aaatcggacg atatggatca aatgagggga 2635801 aatgatcaac atgaataatt ttgttatttt gccaatcctg atcccgcttt tgtcggctat 2635861 tcttctgatt ttcatgacga agaatcttat gctcatgaga atcttcagca cggcggcatc 2635921 ggccatcggg attgtgatta gcggcatact tgtacagact gtcttcacaa aaggcatcca 2635981 gacactcagc ctaggcggat ggaaagcgcc gtacggcatt gtgcttgccg cagaccaatt 2636041 cgccagcctt ctcgttctca caacagcgat catcggttta ttggttgggc tttattcctt 2636101 ccgttctgtc ggtgaaaaac gggagcgctc cttttactac tccggcgttc agttcttgct 2636161 tgccggcgtc agcggagcgt ttttaacagg cgatttattt aatatgtacg tattttttga 2636221 gcttctgctt attgcttcct atatgctgat tgtattaggc ggcacaaaaa ttcagctgcg 2636281 ggaatccctt aaatatattg tgtttaatat tgtatcgtct gccctgtttg tcataggggt 2636341 cggcttttta tacgctgtaa ccggtacgtt aaacatggcg gatcttagcg tgaaaatcag 2636401 cgaatcagga caaaccgggc tgatcactgt gattggtgtc ctgctgcttt tggtatttgg 2636461 catgaagggc ggaatcttcc ccctctactt ttggcttcca ggctcttatt acgcgccacc 2636521 ggcggcaatc tccgcgttgt tcggcgcttt gctgacaaaa gtcgggttat atgcgattac 2636581 gagggttttc acattgattt ttattcacga tacagccttt acccatcagt tgatgatttg 2636641 gctggcggcg ctgactgtga tttttggtgt gatcggttca ctcgcttatt cgaatgtcat 2636701 gaaaattgtg atctataaca ttattaccgc tgtcggcgtg attttgttcg gtgtggcagt 2636761 acacaccccc gcatccattc agggcgcgat ctactatctg attcacgata tgctgattaa 2636821 gggcgctttg ttcatgctgg caggtacgct gatcgcattg actggaaccg cgagcctgca 2636881 taaaatgggc gggctgatca aacgctatcc tgttcttgga tggatgtttt tcatttccgc 2636941 tatttctctt gcaggcattc cgccactgag cggatttgtc ggcaaattta aaattgcaga 2637001 gggcggcttc gcagaaggtg aatttacgat atccatgctg attctgcttt cgagtctgct 2637061 tgtactgtac tctgtgctga ggatctttat acatgcgttt tggggcgaag aaaaagaaac 2637121 gccaaaacca aatcatcgaa cagctaaagg acttctttat ccggcagcta tttttctctt 2637181 gctgtccctt ctcttcggat tgggtacaga atgggtgtcg ccttacgttg atcaagcggc 2637241 cgagacgctg ctgaatccgg aaaaatatat cgaagctgtt ctgaaggagt agatcgcatg 2637301 gcatttcaaa ttttattaaa tgtgtttctc gctttttgct ggatgttctt aagcaacagt 2637361 ccaagcgccg caggattcat tacaggctat attctgggaa tgctctctct ctttttcttc 2637421 cggcgctttt tcactcgcca gttttatcta tggaaattga tttctattat caagctctgt 2637481 ttcattttta taaaggaact gtaccttgcc aatgtcagtg tgatgaaatc agtcttatct 2637541 ccaaaactga atatcagacc gggtattttt gcttttaaaa ctgaactgac gaaggactgg 2637601 gaaatcacca tgctttctct gctcattaca ttaacgccgg gaaccttggt gatggatatt 2637661 tcagatgaca gaacaatact ttatattcat gcaatggata tcgaggatgc ggaaaaagcg 2637721 atttttgaca ttcgggagtc atttgaaaaa gccatacagg aggtgagccg gtgatgttta 2637781 cgctgatcct gcaaatcgcg ctcggcatta tggcagtgtc tacctttttg tatgtcattc 2637841 gtgtcattaa aggtccgact gtgcctgacc gggtcgtggc tctggatgca atcggcatca 2637901 atctgatcgc aatcacggcg cttgtctcca ttttgctgaa aacaagtgcg tttttggata 2637961 ttattttgtt gctggggatt ttatcgttta tcggaacgat cgcattttcc aagttcctgg 2638021 agaaaggaga gattatcgaa aatgatcgaa accgctaagg tcgttgtggc tgtattcatt 2638081 ttgctgggtg ctcttatatg cctcattgct tcatttggcg tacttcgcct tcccgatgtg 2638141 tttacacgcg ctcatgctgc ttctaaaggc tcaacattag gtgtcaatat gattctgctc 2638201 ggtgtcttct tctatttgtg gtttgtgacg ggggagctct ccgctaaaat cctgcttggg 2638261 attctcttta tctttattac gtcgcctatc ggcgggcact tgatctgccg tgctgcgtat 2638321 aactccggcg tcaagcttga tgagagaagt gtgcaagatg actataacgg aatcagaaac 2638381 tttgtgatta aacgaaaaga ggattcttat ttataaaaat aagcagccgg acaggcagag 2638441 ttccggctgt ttttttattt cttgatgaca gccagcgtgc atctggatat acagatcagc 2638501 ctctcttgct cgtcatatat gtgaatatga tagacaatcg tcgttctgcc tatatgaacg 2638561 ggctcggcta tcgcctttac cgttccttcc tttacagatt ttaaatggtt ggcgttaatc 2638621 tccaaaccaa cacaagcttg cgttgtatga tcaatcaggt tctgtgcacc tgcgctcgcc 2638681 gcggtttccg ccagggccac tgaagcgcct ccatgcaaat atccgaacgg ctgtaccgtc 2638741 cgatgatcca ccggcatgac cgcaacgcat cgttccgctg tgttttcaac aatctcaata 2638801 ccaagcgctt caagcaatgt gtgcttcata tccatctcta caccccccaa catttaaagt 2638861 acaccgtctg atttcgcaat caaaaccgct tccgtccgtg aaccgacatt cagcttattg 2638921 aaaatcgatg tcaagctgta ttcaatggac cgcttgctta aatgaagggc atctgcgatt 2638981 tcttggtttg taaatccctt ttcaacttct tgaagaatca ggcattctct aggtgtgagc 2639041 acatcttgtt ctttttgaga ggaaggagcc ggctttgttt tttgctgagt catcagctgt 2639101 ttaaagtaag caaaatcgac taaaatttct ccgttgagta cgtggtatat gtattgggtg 2639161 atcttttctt tagattccgt tttgctgatg gcaccgtgca gacccgcacg aatcgcttcc 2639221 tcgaaataat cctcgacctc ataaccggta tacacgataa ttttacaatg aggattctct 2639281 tgtaaaatct gtttagaaag ctccatccca ttgacctcgc cgcctagatt cagatccatt 2639341 aaaatgagat catatgacga gaaatcatgc tgcttgataa actgttcgct cggttcagga 2639401 ctgagacaat caacagacaa attcgaatcc gtttccaaaa ttgtcttggt gccttccatg 2639461 acagccggat ggtcatcaat cactagtatc tttttcatgt tttcctccct tttactcact 2639521 cttttccatt ttataaaaaa gacttggcct gtgccaagtc gtttccgtta taaatccatt 2639581 acaattcgat ttcaatatca gccttaaagc cctttccttc acttgtttca atccgaaggc 2639641 gcccatctaa agccctgact ctctccttaa tgccagaaag ccccatgctc atggaatgct 2639701 cagtattttt ttcttgatca aacccaacgc catcgtcctc ataatgaaga acgattttgt 2639761 tttgaatact gatgagcata atcagcacat ccgtcgcctg agagtgcttg accgcattag 2639821 acagaaactc ttgaatgatc cggtacaaat tcagctgcga atccagatca agggaagccg 2639881 taaatctccc ggtatttaaa cggatatgaa acggaacccg ctcctgctgc tgcgccacca 2639941 gcttcgacag cgccttcacc aatccaagat catacagaag ctgcggccgc agctcatgac 2640001 acgtctccct cgtcatcgaa atcacatcag acatctgctc attcatctgt acaagcttgt 2640061 cctgcacctc ttcacggcac ggattatcat ccttcttgaa atcacccaaa aacagctcac 2640121 actggcgttt taaggaaatc aaatcctgaa gaaccgaatc gtggagatcg cgggcgagtc 2640181 ctgaacgctg tttttcttcg attgcaaaca ttagcttttt cagccagatg gggttggttc 2640241 cctcttgttt taagtccttc aaatgttcca tgagctcctc aatatgcagg acattttcca 2640301 tggacacact tgtataaaaa gacagtgttt tcagccacga tatttcatca cgtgttagcc 2640361 ggggagtgtt aatattagat aaacaaagca gaacataaga actaccgcct cgttcaccaa 2640421 ctttcataag aaagccttga ttgacttcta taattttccc aatttctgaa gttacgtttt 2640481 caaattcctc ttgataaaaa ttccagtccg gtccaacttc atgcttatct aaaaatatca 2640541 ctttgtgatc aggagtaacc tcaaaggtat aagctttgct tacaagcaaa acatccagta 2640601 tagtattttt cagttcttta aaaacttgtt gaagagaagt tacacccctc attagctgag 2640661 tatatttaaa aatactgtcc tgatagttga atttttcgga gaaacgtttt aaccgaaatt 2640721 taaaatccat gacctcttta aaataaaaga cagcgaacat gacaacgaaa aaaaatacag 2640781 tttgacgcac agggttcatc tggatgtcca ttacatcaaa cagaactaat gcaccaacta 2640841 ttagaagagt tggtatcatg gcaagtagag catagtatct cattcttcct aagataaact 2640901 ctatatcaaa catcttattg gctacaaatt ggtatactaa cccgaacgga attagtacta 2640961 gtaatgacgc cgaagctaat gccgggaaaa tataattacc tgtaaatatt attggaagaa 2641021 caaaaaatat caaaaaaggc gcaaatgaaa gagtgtttgt taaaattagt aatttaagaa 2641081 taaacgaatg ctcagcatat ttatatttat taagatgtaa gtatatcgct gaaaaagaaa 2641141 atagagtcaa agttgcaaaa gaaaccaaat taagagttgc taaaaaatca atatctactt 2641201 gtaaatagtc ttgaaaaaac tcaataccaa gattaaatat tggtatgata taaagaaaag 2641261 aaattctatt caaaaaagtt ttacctattt ctccaaggta tctttgtata aattgaagat 2641321 aaagaatagg agaagatata aaagtaaaca agttaatata ccgattgatt atatgtcctc 2641381 taaatggtcc gcctgcactt atatatgcta tcgaaatgtc taataacaat agaataagaa 2641441 tataggcagc aaatgatctc ctttttttat ttactttaag tatataaaaa atacatatta 2641501 tgcttaaaaa ataaaaaaac aaaggaagta cgaacagaaa aaaactataa ggtctattta 2641561 gagtaactaa atcaaaatct ttgagatgaa tcttttttcc acttctcaaa atatccagac 2641621 tgttaatatg actcaaatat ccccatttca aatgtttgtc tgaaggtttt tctttattaa 2641681 tttttaatat gatgtctccc tgtctcagac caacaaattg tccatatgaa gattccgata 2641741 tttcttctat cataaattga cttttatcat ttttatgaat cttagtccca ataataattc 2641801 cattcatact gatataagtt gtatagctta tataaaggat actcaaaaca attacagcta 2641861 ttgtgaattt ttttattaag ttcttcaata ttaatccacc tattaatcac cccattgacg 2641921 ggttattgga tcagccagat aataatcatt ataagcttta attattgttt cagtttcttg 2641981 cacatcaaaa cctataaggc aggcttcttt atttttcaat ttttttaaag cctcaggata 2642041 atttaaaaag tagttaatta ggtcttgcat cttgtatccc cctttgtata acttaataag 2642101 cattccttta ttagctcttt ttttctttat ctaaatttaa ttgttctata gcagaaatac 2642161 atttctgttt atatatttcc aataataccg aaatgtattg agtaactccc gctttaatta 2642221 atttttcttg gaatttctct ttatcaagta acgatttata atataagtct ttatgtgaaa 2642281 ttaagtataa taaatcttcc gaagcatcat taaaaaggcg cttaagatat aagtaaatca 2642341 gtgtatgttt gtttttttca atatcactgc gatttccgga taaaagaaca taataatctc 2642401 cagaaatttg agctataatc cctttatagt aggaatatct ttcaactgtt tcattatatt 2642461 ctcctgtagc caataaaaca cctgctacat ttgctagtgc aatcagactt ccacatttta 2642521 atctaattac ttctaaactt tcatcttctg ttttagattt attagtgata tcgtcatgtt 2642581 gaccttgcat ggcctcgttt acgtatttta aaacatattt aaaaattaga ggattgttat 2642641 ttaatgaata aatactcgtt aatcctactg tatacaagga aagtgctgca tttaacgact 2642701 ccgagcgatt aattttcatc cataatgcat ggtgattatc ttcatcttca agatcatcca 2642761 taatatctga tgaaagaata agaatttcta ttcccgcgcc aagccttgtt gcaacatcta 2642821 aattctcccc tccaaaaaca acataatgta agattgtgga ttcagcaaag gagaatgttt 2642881 ctttagaatc aataaatgag taaagaagtt gtgacaaatc ctcgttaaat atgttttgct 2642941 ccacaatctc cttcattttc tccttgatcc ggacagaatc taaacatatc tgctcaataa 2643001 cgacttcccc cctcccattc cattttacta aatgggacat ttaaaggaca gcaggttttt 2643061 cgttttttaa caatcatata atactttatc catttattgt atcggtagaa cgaaaaaaaa 2643121 gacttgtttc caagtctttt tcacgaaatt ttcattgcat aattgtattt atcgagttga 2643181 tcaatgcttt tgttaatgtt tcgtaatgaa tctgtcgttt ctttaatatc aagttcgagt 2643241 cggaataaca attgttttac ttcttcaagt ttcttttcca tcgtttccac actccttttt 2643301 ttgaaagatc aatgaattgt gtatggtgaa cgagtcctag gtatttgatc tgttactaat 2643361 agtgtgtctg ctttcggctc atttttcacc gaaaagtatg caaaaaagtc ctgcgtgaca 2643421 ccgcaaatct caataggtcc ttatactcaa aggaatcaca acaagaacgg gactatcttt 2643481 ctatgcgaaa gagcgtttat atgtgctgaa attgagaaag attcttaatc tccttgattt 2643541 taacgggttt cgcattttca ctaagcaaga ctatagtcct tcataccgta ttttcaaaat 2643601 tgaatatgcg attcttggcg tttcctgacc gacaaacacc gaaaaagacc gcaacgctaa 2643661 agttgtggcc ttttcgcttt gtcatattcg gcaattaggg atctatacat atagaaacat 2643721 ccttttttgc gaggtgctcc catgagatat cgttatccct ggttttacgt gtatccgtat 2643781 gaggtacgcc gtccgcccgc tcctgccaac aatattgata cctttatccg ttcagcgaag 2643841 caggccgcag ggatatttgc ggatgcccag ctcgttctca gccgcattgc gggctcgcgg 2643901 gagctttcgc gccgcattct gaccgcagcc gaacagtctg ataaacaaac tataaggcgc 2643961 ctgatcaaac aaatgggcgt ccggcatgaa gtggatacgg tctttaatcc cgacggcatc 2644021 tatatcagcc ttatcggaac gcaaagccga atgattcttg ctttgcggtg gtcagaggac 2644081 cgcaatcatt ttgcgtccat aagattatga caccattcca gagcctctaa ataacattca 2644141 tacgcttctt ctttgtccag ttgattgcct aattctgagc aagtgtccca gttgttgctt 2644201 tcaattaatt tcacaagctc aagcatttgg tagtagtcgt tttgatggcc taataatgct 2644261 tgcccgactt catcttttaa aggcaattct tgaacaattt cctctatttc tctatgcagg 2644321 agggtgtcta tgagagaaaa cattccgatc agcatataag aagcaggctg cggccgggat 2644381 gtctttctcg ccagcagttc gcaaagcttt gctcttatca gagaaatctt aatgatttcg 2644441 tgcttgctgg aatgcccttt cctgcttaaa tccttaaagg aaagaatata tatccaccgt 2644501 ttgatttcat taaatcccag cagcataatg gcctgttgaa tgctttcaat tttctggctc 2644561 aaacggctgt gggatgagtt taaaaatttt aaaatttgat aggacagtga taaatcccgc 2644621 tctatgtact ctgtcacacg ctttatgtta ggctgctctt tactcagttc gttaagcagt 2644681 tcatagtaag aatagaaatg agtcgatagg tcatgcccgc tgatgatgcg cggctcgctg 2644741 aaaaagtagc cttggaataa ttgaaagccg tcttggaccg cctgtttata ttcttttcgg 2644801 gtctctactt tttccgctaa aaaaatcagg ccgcggcagc cgtaggtttg caaaattgtt 2644861 ctgcgttcca ttcgtgttgt tttgagaaaa tcaattttca atatatcaat atagctcatg 2644921 agtttttcca gtaagtcctc atcttgcgga tttattgcat aaaaatcatc aagcgccagc 2644981 atatacccca tttttttcaa ttctttgcat ctagaaatga gggccggcgt gatcggtata 2645041 tcttcaagga tttcaatgac aagctgtttc ggattgaagg aggtgggaag attcgaaaac 2645101 atcaggcttt ccgtaaaatt aacaaaacag cgtttccctt ccgtcagctt ctcaattccg 2645161 atgtttaaaa agctgttgat caccaaatct gttgttgcct gatcgccgtc tttagcgcta 2645221 tacacgttct cttcgctttc tctatacagc agttcataag caacaacctg ttcttttcta 2645281 ttaaaaatag gctgtcttgc aacaaacacc ctcattgatt tatccccctt acaatacgcg 2645341 cggctttcac ccctaagtat atcaaataat ttgacgaaaa ttgtctaaac atgaaaaata 2645401 atatatacat aaagaaaact ggcccttcgc gaatgaaagg ccagtttttc tttattcttc 2645461 ctcaagctct tcttcaattc tgcttttcac ttcgtggatc cgctgcattt tattgctcca 2645521 gcagtcctcg cttaaatcaa ccgggtattc ctccggcttg ctgattctct tatattcctc 2645581 ccaaagcagg ctgaggttat cctgcacata ctgctgtatg tctgaaatct cagggttttg 2645641 gtagcaaaga atacccttct caaaaatcag ttcatgaaga tccttcgcat aaaaattcgt 2645701 gacaaatttg ctgatgaatg tatgaaccgg gtggaacatt ctgagccgct tctgatcatt 2645761 cacctgctca tcataaagcg caatatagtc gccttcagaa tgatggttgg actgattaat 2645821 aatgcggtag actttctttc tgcccggtgt cgtcactttt tcaggattgg acgaaatttt 2645881 gatcgtgtcg accattttcc cgtcttcttc aatggcaacg agtttataaa ctgcgccgag 2645941 agccggctgg tcataggcag tgatcagctt cgtaccgaca ccccagacat caatgcgcgc 2646001 tccctgagcc tttaaattca taatggtgtg ctcatccaaa tcgcttgaag caatcacctt 2646061 cgcatctgta aatcctgctt catcaagcat tttccgggct ttttttgaca ggtacgccaa 2646121 atcgccgctg tccagacgga tgccaatgaa attaatgcgg tcgccgaatt ccttggcaac 2646181 cctaatcgcg ttcggcatgc ctgaacgaag cgtgtcatac gtgtcaacta agaagacgca 2646241 atccttatgt gtttccgcgt attttttgaa agctgtatat tcatcgcggt aagcctgcac 2646301 aagcgcatgc gcatgtgtgc cggaaaccgg gatattaaag cgctttccgg ctcttacatt 2646361 gcttgtcgcg ctaaagccgc cgattaaggc tgctctcgct ccccacatgg ccgcatccat 2646421 ttcgtgcgcc cgtcttgttc cgaattcaag cgcaacttca tcaccgatga cgcctttaat 2646481 ccgggcagcc tttgttgcga ttaatgtttg atagttcaca atgttgagca aagctgtttc 2646541 aatcagctgc gcttctacca ggggtgcctc caccctcata atcggctcat tgttaaaaac 2646601 gagttctcct tctttcatgg agtaaagtga acctgtaaaa gataagccgc gcaaatattc 2646661 aataaaatct tcatgatacc cgagttcatc ctgtaaataa ctcaaatcgc tatccgtaaa 2646721 cttgaaattt tccaagtatt caatggcttt ttccaagccc gcaaatacgg catagccatt 2646781 ttcaaacgga agccttctga aaaacagctc aaaaatcgct ttcttttcat gaatgccgtc 2646841 tctccagtac gtttccgcca tattgatctg ataaaggtct gtatgtaatg acaggctgtc 2646901 atctttaaat ccgtactcta acactgtttt tccccttcct tactctgcca cttgcgctcc 2646961 gatgctgttt gcaaaatggg aaagagccca tgcgtgcccc tcctgattaa agctggcaac 2647021 agcttgttta tgcacaacaa tccgaaaacc tttgttgtat gcgtcaacag ctgtatgcaa 2647081 cacacaaata tctgtgcaga caccggcaag atgcagttcg ccaatctgcc gctctctgag 2647141 tttgagctct aaatcagttc ccgcaaaagc agaatatctc gttttttcca tgtagtaaac 2647201 attaggttca tgttcatgtt tctgatatag aggcaaaagc tttccgtaca gatcttttcc 2647261 ttccgtgcct tttatattat gcggaggaaa aagacgggtt tcagggtgat attgatcccc 2647321 ttcatcatga gaatctactg ctaatacgac gtaatcaccg tttgtgatga attctttagt 2647381 taaattgacg atcgcctctt caatcattct gccgggctcc ccgcaggtca attttccgtc 2647441 actcgccaca aaatcattcg tataatcaat acaaataagt gcttttttca tagccggcct 2647501 ccccgccatc agtatgagaa cattatatct tatctccagt tgtaagtgaa ttgccatgaa 2647561 caaaaagaca aacggtccgt ttgtctctta cgatttcagt actgaccgat tataaatgtc 2647621 gtcctgaata tatatcaatt cacgattcac agcgatatca gccgcaatga cgatgcctaa 2647681 gggcgtatga aactggagat cagatacaat cttgaaaggc actccgtacc ggctcgccat 2647741 ttggatataa gaagagtaag actgatactg aagctctcca ttaatcaaaa gggtgacgtt 2647801 atggctgttt ttcagctcgt gctctgcctc tttatacggt ttgcttctaa gcacctgtcc 2647861 tttcgtcagt gccaaaacga ctctttctct taaagagcct aaaaacaaat ggcgctcgtc 2647921 aggctttgtc tccaaaggcc catacattcc ttgctgcaaa tagagatcca ttttatcttc 2647981 actcaaaagc ctgtcctccc gtcttgtttg tcttcattat cacctgatca ggcaggagct 2648041 aaactttcaa gcgccgttta catttctgtt acccaatgaa tgattttttt ggccagctca 2648101 ccagcagggg tttcctctgt atgccggcgc aacgacgctt ccagccgttc aggcagagtt 2648161 gctttatctt cttcatagga aatgatcgtg ctccactcca gctgcggtac cgctacaagc 2648221 gtgcgcagtt cttttctgtt ttcatgcaga tacacgtccg tgatcattcc ggtttgcgta 2648281 ttgatatttg cttttctgat tttcataaca tgacctctct attcaaagac tacccatatt 2648341 atacaataaa aaagcaacag cctcttgtga aaaggctgtt acccgttaaa cgaaactgtt 2648401 tcatcagtga tatcggcatc tttgaagaga gttttactcg tttggttgtt aatcttcaca 2648461 aaatcaccaa gctgaaatgt gcctgacccc gcccctgaat gagcgacgct tttgggcgaa 2648521 atcgcaaata cgtctccaaa gcttgccgcg gcattatccg taactgacat gatataaatc 2648581 ggccccacaa ttgcaggcat ttccccacct ccgcattgat ttacagcatc atatgcaagg 2648641 agccgataat ggtgcccgcc tattcagctg gctttgcgtt ttcctcgagt cgtgaccgct 2648701 ggcgcagctt gatcaagcgg acaatattca ggaagaacgc cttcactacc gcataaaccg 2648761 gcaccgctaa aatcatgccg agaattccgc cgaagcttcc cgctccgatt aatagcaaaa 2648821 taatcgtaag cggatgggta ttcagccgct ttccgatcac aagaggagac agcaggtttc 2648881 cgtccagctg ctgaacgatg acgaccacaa taatcgcaaa cagcgctttg gccggcgagt 2648941 ccataaaacc gacaatgaca gccggcgcgg caccgagaaa aggcccgaca tagggaatga 2649001 tattggtaat cgccatgaca atcccaagaa tcagggcata cggcagtccg gcaattaaat 2649061 agccgataaa acacgctgtt ccgacaaaaa gacagattaa cagctgcccc tggaaatatg 2649121 ccgcaagcgt atcggataaa tctttaaaaa tctttaagcc ttctgtccga taagaagccg 2649181 gtagaatttt tactgccaaa tgcggaaagc ggtgtccgtc tttcagcatg taaaaaagga 2649241 taaatggaac agtaataata acaagcgtga tgtttgtcac gacaccaaac accgcagata 2649301 aactggacgt gatattttgc ggcaggtttt ggagaaaact tgtcaatgac tgttcaattt 2649361 ttgatatcga tacataatcc tggttcatca tccaggtaaa ccattgagaa tgggacaaat 2649421 cctttgtcag cgcctgaatc tgttttatat aatcaggaag gttgttaaac agccctgtca 2649481 cctgtgcggt gatgataggt ccgactgacg ctgaaataaa ggcaagcaaa ccgataaaca 2649541 gtaaatagat caatagaatg gataatgtcc gcggaatttt tttctcaagc aggcggacga 2649601 ccggattaaa tatgaaatac aaaattcccg caattagcat cgggaaaaac aatgtcgaga 2649661 taaaaacaat aaacggctga aatacaaatg aaacttttgt tgctacaaaa ataatcagca 2649721 aaacaaataa aatctgcaat gtccaaaaat ggacttttga tttcaacaag ctttgttcct 2649781 cctagttttt ctttgtctgt cagataaaag aacttatacc ccatcattgt aacaaaaatg 2649841 aactcatatc agaactctta atataatgaa aggagtgttg gtgatgaagg ccgtgacata 2649901 cgatacagat tcagaactgg cttatatcta tgttcttcct ccgaaaaaga acaggaatgt 2649961 acggactgag gagctcagag tcaatgattg tctcctgctg gatatcagcc aagatggcaa 2650021 aatcgccgga ttcgaatgtt ttggtgaggc agcacacctc tgtgccccat ttgccgggaa 2650081 atcccggctg tatgtaaaag attcagacgg ttatcatttt cgggtctgcc agcatgcttc 2650141 agtccgttcc tgctatacgg tgtaccgtgt cactttctgt ttttcagatg gtgactatca 2650201 ggaatttgcc ggctttgacc ttgatggaac aatgtatcat agtgcgtttt tacagcgctt 2650261 aactgaaaaa taggacgtcc tgttgtacgc ctatttttca tgcgcaagca ctgttagacc 2650321 cgctcactgt aatctggggt gacggaaatc atgtgctgga ttctgatcaa acaaacagaa 2650381 tttcgggctc cttcaattgt gatatggtca ggttttacat cgatcagtct gcctctgacc 2650441 gtatctcgta ctgtctgtat aacgaacctt gagccgatga gctttttaat ggtctgatag 2650501 acataaggat cgactaaaga gaccagttgc ggactacctt ggttgaccat acttttatcc 2650561 cctttgtgtg ttttatctca gcttatgccg cgcttatgga taatgacaca ggcttacctg 2650621 ataaaacaaa ggggtgcgga gattttagga gaatacgttt ggaggcgggt gtaaaggaag 2650681 tatcgatgaa gcggagacag cgaagaaagc tggcgctgtt ccgtacttat acaggcttta 2650741 tcacggatgc ctgggcttgg tcgattaatt ggtccagctt ttctattttt tttcgtgcgg 2650801 ttgaaggatc aatttggcgg taatgatggt ggccgcccgg ctcttcatcc agttcgtccg 2650861 cttttttgac aatctgctgc agtgtgtttt tatctaattc gccttcaggc aaataggaat 2650921 ctgtatgaag caaaatggct agtgcaatct cttttgctgc tttcggttcc tcgccaagcc 2650981 gaatcagaag tttatgcgcc cgttccgccc ctttaatggc atgaatgtca tttcttttgt 2651041 atttctcata atcccacttt ccgtctgtat accattcata atggccaatg tcatgaagca 2651101 gtgccgcttt tgctgctaaa tcaggattaa tgtcagcctt cacagacagc ctgtatgcat 2651161 gataagcgca ggcaatcgca tgtgccacgc cggaacgctg aagatatttt tgtgcaattg 2651221 gatgggtgaa aacatccatt aatgtaacct ttctcatgga aacccctcct ttagatattt 2651281 ttagaatcct aacataattt gcagagaaac tcaattctta tgtcacatca ttttgatctt 2651341 cttatcatca ttgttatacc ctaaaagcaa cgtttcagtc agtatatgcg gctgttcaat 2651401 aaaatgcgct ggctgcagcc ttttgtataa aaaaaagagc agaaaatatc tgctctacaa 2651461 aaactcttta atatcataaa tgcggccgtt ttccgtccct ttttctagta aagaaagcag 2651521 cgtgccggca ataaagtccg gactgcgaag gcttcctgtt tcatttaatt tccggaatcg 2651581 ttcaatgtgg tggaaatcct ttttcgatga agaacggatg acggcctgca tctcagtgtc 2651641 catcactcca ggtgagaacg aaatcatgtt caccggcagc tcttcatcct cctgttcaaa 2651701 tccgaatgtc ctcgtaaaca tgtcgagccc ggcttttgaa ctgcaatacg cgctccatcc 2651761 cttatatgga tttttggcgg ctcctgaagt aatgttgaca accgtctttt tgccgctgta 2651821 tgaagcaaac cgttttgtaa acagctgact caaaagcacg ggcgcagtca ggttcagctg 2651881 ataatggcgc tgaagctcgt caagagacgc ttcgccggca cgtttgatcg gcgttaccat 2651941 tccggcgtta ttaataaggg taataccaga ataacgatct gaatcgatgg atgagagcaa 2652001 tgtttcaaat tgctgttcag cttcttcgag attgatgagg tctatttgat gctgcgttag 2652061 ttttttgtga gagacatctg ttttcgttct ggataaggca tggacttcat gccccttttc 2652121 taaagcctgt aatgcaatgg cttgacccag cccttttgac gctccggtga tgatataaag 2652181 ttccattgga aacctccttt tccgttatta ttgtacggca cctcttttac acaacacaag 2652241 cacgcggcct acgccttctt gttttcctgc gctgtgactt ttgggatgag gaacacgatg 2652301 cctgcaattc cgagcaggat cagtacgaca tagatcatcg gcagcagcaa tgatgatgtt 2652361 tcttgttcat cttctgtttc cgttgatgat gtctttgtca ttggtttttc agcaaaagta 2652421 attccaagct gtttcgactg ggccgcaatc gtgttggaat cctcggcatt tgttgatgta 2652481 aacaaatctt ttatcagctc ggcgtccttg tccttcggtt tatcaaaagt gatatccttt 2652541 tgttcctcag gcagttctgt tttttcttca tagtaggtat cttcatgcaa ataattcgta 2652601 tcgatttcga tgtctttttt ctcatactgg tttggcgcga catctgtatt ttcttcagtt 2652661 tgggcagccg ctgcagaggg tatgaaaagg gaaaaggaga gcatacaaat catgatcccc 2652721 ttttccatgc tgcgatcacg cttcatacgt ttcatcgctt tctgctgtgt gttcagccat 2652781 caaccggata atcagcggca gagccacggc aatcaccgta atgatcagca gaactgttat 2652841 tcccattgta aacaagtgcc cagtaccgta ctggatgtcg atatatactt tcgaaaccgg 2652901 atcttcaaat gtaaagttcg gcatgatcaa atcaataagc ggtgcgacat agaataggat 2652961 cattgctgct gaagcaaccc agccagggat tgatccgaat ctgaatgccg tccggatgaa 2653021 ggcagagctt gcgaccagca atagaatcgt aaacaccgac cacttaatcg tctgatcgtc 2653081 cggcagtgaa taaatattca agccgaacaa gctgatcata agtccgacaa ggatattcag 2653141 aattccgaat aacgctcctt tgacgagaag cggtgcgttt tggtaatacg agctgaaata 2653201 gccgattaac agactgctga tcaacacaat gacaaggatg acaaccggag gtaccgtctg 2653261 aattttttct tccggaacct ctccgctgat tttaagcgga ttcgctaagt aatcatatac 2653321 atagccattg ttttgcccgt ctactaatgt atttccgagt atgccgtata cgtcatttcg 2653381 cacgagtttc gtggaggcga catttttccc ccagttgttg tttaaggtgt cggctttcgc 2653441 ttgaacatca ttaacgcttt gctgcatgtt ggttgtgtaa tcaatgatgc cggactggcg 2653501 atcagacaat gaacccatca tgtctgacat ttgcagcact tcctggccga ccgtatcttg 2653561 gacactcagt gccatggtac cagacagccc atcgttgctg aacgtcgcag attcctgtgt 2653621 tgcgcccgtt acaagctgtt ctgacgcttt tgcggcactt tcagagattt tcgtcagttc 2653681 gtcgagaaca cctgcttgag agtcacggat atagccgctg tagtcgtccg caaatttggt 2653741 catgccgtcg atgaagctgt taatatcctc atctgtttgc atcgtgttgt ttttgagagc 2653801 ttcccagctg gctgattctt caggtgtgag agccaggact gattggacgt tgccatcttg 2653861 ctcttggatg acttcacctt taataatagt caaagagcct agatccagat tatcatttag 2653921 cgtagactta tataaattta aagagttgta atacttcatc aagttagaaa tattatcagt 2653981 ttcaattcta cttgaaaaaa ttgaacttag tttttctttc tgatctatat agcctctact 2654041 ctgcaaagtt tgtattattt cgtcttccaa attgtatatt aacctataag catcattgac 2654101 attattatca aaatcaacca acttttttgt taagtcacca atttgatcat ttaattttga 2654161 aactgtttta tttaactctt taatttcttg atttaactca tcaatatgtt tctctagttt 2654221 gttgttatgt tcctcttgtt tttcttgaag tgcattttct atttcctcta attttatcgc 2654281 tgcttcgttc agacgttttt ttgcacctga aatatcagtt tcaccgtcag ctccgtcacc 2654341 ctgtagccca tcactttgat ttgagccatc gttttcatct gcgagttcaa tcaaagagaa 2654401 atctgtttta gaggttcctg tattctccgt gtttgtatct tgttcaggaa cgttttttga 2654461 agattcttga tgtttttgtc ccgtttcaat gttagtttga acatcatttt gtgatccatt 2654521 atcttgagta ccctcttctg atgagccagt atcttcattt gttggctgat catcggatgt 2654581 tggaatatca ttcgacggtt cttcagtatt aggagaatca tcggttgatg gttcttcagc 2654641 atcgggtgtt gttggttttt cttgttcagg ttcttttaac ccttcagaga tatctttaat 2654701 ttcagttgca acatttttga gctcatcccg ctgcttctct aaatccaatt ttatatcttc 2654761 aatatcttcc ttatctgtgt catctttatt atcagatgtg tcttctccat cttccttttc 2654821 gtcgctttcc ttaggtttaa gtaaactaag gcggttcttc ccgatattct cttgcaattg 2654881 atttaaattt tgatatttaa tagcttcata ttgactttta tatcgagata gaaatgcatt 2654941 aaacatgtca ttctcaattt ttttcatacc catttcttgc aatggcactt gattttgcct 2655001 taacttttca gcattgttca acgcaaggtt tgtcagtcct atttgtgtct tcgcttggcc 2655061 gatcccggtt gccaatccgc tcatgcgttc gctgaactga ttcgcctttt gctgtgcctg 2655121 gatggcatcc agacctgtcc ggatttgctg ctgtgttgaa tcctgggctg ccaaaagcag 2655181 ctttttctga ttctcttgat attctttgta cctttcaact gtatcaatga attctttcag 2655241 cgtgtttttg gcttcctccg ccgtagaagc tttttctttt gtcgtgcctt gcgcttcatt 2655301 cattgatttc ttcagctcat cgattaagtc tttttgctgt ttgatttcac ctgctaaatc 2655361 attagagctt ggtttgtaaa agttgtacat gacattctgg aattcagatt ctttattgac 2655421 gatcttgtca aattctcctc tgatgttgtc cactttttgc gaaacaaaat tccagtataa 2655481 ggccgacatt tttttgttca ttgtcttttg ggcatcctca agctcacgct gaactttttc 2655541 tttgttaacc gcattcaggt tatcttgaat gctgaattcg agcgttgcct tttgaggatg 2655601 gtctttgtca tagctcaaaa tgttttttga gaagtctgag ggaatgtaga caatcgcatc 2655661 gtatttcttt gaagcgagac cggtctcggc cgcgcttcgg tttacgaccg tccacgaata 2655721 atcaggacgt tcacccagaa cggccgctac ttccttgccg aactgggcgg atttgtcctc 2655781 ttcatcagac tttacctcat cactcaatac gcctgtgtct tcattcacca ccgcgatttg 2655841 ccgggtagaa ttgactgctt ttttcgttgg gtcgtctccg ataaatcgga aaaacaacac 2655901 cggcagcagc aaaatgatga tgacggcgga tattaacttg atcaagcttt ttcgttgttc 2655961 tgtcatctag cactctccct ttcagcagaa cataaaggaa tttgaacttt ttgctccttc 2656021 ccgttttcca caacatatcc gaagcccggc tgaatctcag gctcctgtct ttggtacggg 2656081 agaggaatga cattttgctc agactttttc atcagcagaa tcgcgtggcg gatttgcttc 2656141 atctcagtcg tcaaggagtc atagcctttt gagaattcgc tgtggtttcc gcccgggata 2656201 aagctgaacc caagatgagc gtatgatttc atgaagttag cgagacgatc ttgtattctc 2656261 gtatcaatcg tctgctggaa tctcgttatc ccgtcaatca tcagcacgac ttgtgagaat 2656321 cgcagatttt gtgcgtctcc ttggcggacg gcttctacat acatggcttc tcttgttttg 2656381 aaaatgtctt ctgctgtttc aatccactgc tcaatatctt ctttcgtttc caaatatgaa 2656441 acatctgatt ccttcgcata atgagataag ccgcggtcaa tcgagtcaaa caggccgatc 2656501 atttcggttt catcatcaat cagatgttca agcatgactt ttaggacgtt tgttttcccg 2656561 cgctgagttt ggcctaaaat caggcagtgc ttatgcttgc ccaaatcaaa atagactggg 2656621 ctgactgttt cttcatgaag cccgatcggt acagataaag gcttgcgttc cagcttgaag 2656681 cggatagaca attctctcgt cgacaagctc tcaggcagca tcggaatcgg tgccggctgc 2656741 tccattgaag caaatcgccc ttgaagtttc tgtacgtctg atttcagctc gttgaacatg 2656801 ccgatatcat catcggcgtc aacaggcagg aacatttgcg cgaaataaag ctcttccttt 2656861 tgaatgatga cgcgtcccgg aatcggctca agattgaatt tcggacggcc gtaaatggaa 2656921 tatccttctg attgatccat gagataatgg acaatctttg ttttcaagtt atttaacaat 2656981 gactggcgga cagcattcac ccgcgttgct gtcagcataa agtagatacc caagctttgt 2657041 ccgtctctgg aaagctggac aaattccgat tcaagctcat gcatctcatc cttgacaatg 2657101 tcaaagttgt caatggtgat aaaaatgaat ggaagctctt cttcgctcag cgcattgtac 2657161 attttgatgt ggctgatttc tttttcccgg aacaaacgtt tacggcggtc aatttcttct 2657221 ttgatgcgaa tcatgaactt ttcaattttc cttgactggt ccatcaggaa gtaatccgcg 2657281 gtatgcggga gcttcgctaa tggcagcagc gttccgtttc cgaaatcaaa gatatagaca 2657341 tgaagctctt caggtgtgta tacgtccgca aaactcatca ggaacgttgc ggctgcaatc 2657401 gattttccgt agcccgaaga gccgaagatg ccgatatttc catcttccat catcttataa 2657461 gcaattggcg cctgtctttg cagatcaggt tcatcgacat acgcaaagtg gaaatggtct 2657521 ttttcgtttg aagggaaaag agtgcgcgga atacgttccg caagcggcgg cagccaaggg 2657581 cttggcagct tctcgattcc catttcatct tggatgcgtt caatttcgtc aactacagct 2657641 tcgatttcgg tttgaacgtc ttttttcgcg ttatcttcgg tatcaacctc agaaagcggg 2657701 atcagacccg tatctgtgac gatcgcgatt tcatcctcgg taccgtagac ttcctctaag 2657761 taaggcgccc cgctccatgc agattggaac agctcataca cttcattgtt tccgacctgc 2657821 aaatagccgc ggcctgttac ggtaatgttt gcggcatcgc tgtttttcaa aatttcttta 2657881 ctgtcggtgg catcctggac cttgagcgct actttaaagc gcgagttact ccagatctgg 2657941 tcgtcgatga tgccgcctgg cttctgtgtc gccaaaatca aatgaacgcc gaggcttcgt 2658001 ccgatacgcg cggcactgac aagctccctg ataaaatcag gctcctcgct tttcagctcg 2658061 gcaaactcat cagaaattaa gaacaagtga ggcatcgcca cttctgcttt cccttgcttg 2658121 tatagctttg tatagtcatt gatgtgattg acttgatact ggtcaaacag gcgctgcctt 2658181 ttttttagct cgcttttaat ggaagcaagc gcacgcatac tgaagttttt gcttccttca 2658241 atatttgtga tcgtgccgag gaggtgggga atgttacgga acggctgcgc cattcctccg 2658301 cctttatagt caattagtaa gaaagccgct tcatgcggat gaaaatgcac tgcaagtgac 2658361 aagatgtagg tctggagaaa ttcacttttc cctgatcccg ttgtccccgc aagcaagccg 2658421 tgcggaccgt gtgctttttc gtgaaggttc agatacacaa tgtcatcttt ccctttatag 2658481 ccgatcggca ctgacagcga cttcgacgat tcacttgtca gccatctttg ctgaatgccg 2658541 atttctttta cttccttcgc atgaaaaagc tccaggaacg ataccgtttc cggaatggaa 2658601 ttcgtaatgc cgacctggtg gttcagcgtc cgcagtgtgc gtgaaaaccg ttcgttatcc 2658661 tcacgctgat gatgatcgag acggaacgga attcttaccg cttttttctt ttgtattaaa 2658721 atgtcgcctt catgctcatt aatgtagcgg acaagagttg taatgttttc cgacaagctt 2658781 tcctttgttt ctgcagcgac aattgtcgag atgcccagat gctcatgctg cccttctaaa 2658841 tattcgagaa tgacatgctc agagatcagc tgctgattcg tgatgacaaa tacaaaatgc 2658901 ggtttgaact gcagtttttc tttgtcatct tcgagatcac gctctctgat caattcgtaa 2658961 agtgaagaca ggagctgatc tcgggtttgc tcattataaa taaatccttt tgcataaata 2659021 tggggcattt gaaattgcgg aagccacttc atccactccc agtctttata ctcttcttca 2659081 tgaaaaataa atacgaaacg caaatcgtga tagctgttaa agaacgacag ctgtccgatt 2659141 agctggtgaa tctcattttt cacaatttgt gatttaccga caagccccat cggaccttct 2659201 gccaaatcga ccgtcaccgg cgcattacgg atatctttat agacgcgttg catgtgctgc 2659261 gatttctcca tgaggtcatc gatatcacga ttcgccaagt ctccgccact catattgatt 2659321 tcatagcttg acggaactgt tcccgtccca agccgcagct ggagataatc cttgctttca 2659381 agtgattttt cccagatccg gtcactgatt tcacttgtta agtatttcat ttgttcaaat 2659441 gaaggaaagt gaaattcaag aacctgcttt tgcttttcag caagtgcctg aagctctttc 2659501 cgcttattgt ctaagtaaag cttatataca cgctcccgtt tttcctcgcg ttttttccgc 2659561 tggtttttat cacggaaata ttgcactgtc gaggtaatga gagtcatcat aaacatcgcc 2659621 aaagaaacga gtataaatat gccgcgcggc tggatgatgg caactacgcc catcacgatc 2659681 agcatcacaa gcggaggcag gatgacgagc cacagccctc tgttggtttg atcgctctcc 2659741 tgagagggaa aactgaaaga aacgcggtca tccggcagat cgtataccat ccgcggcgtt 2659801 cttctgtact gcggatattt tttctgcatc tctgtactcg gtttgaccgt ttctgttaac 2659861 gctgtttcaa actgggcata atgaacaatt tctaaaaggt cttgttccgt caccctcatt 2659921 tgcgtgaagt tccagaatat ttcatccccc ggcttgagcg gcgtattggc gttgattttc 2659981 tctccgttca agaagatcgt tccgctttca gggcggaccg accagctgcc gcctgcacgg 2660041 agcaaagaaa acgtgctttg ttctgcaaat gcaaaatctt gcggattcag ataaatatct 2660101 gcattcgttt tttctgagga acatacaatt tcatcccgat ttcccgtaaa ataaacggat 2660161 ttctcaggtt cactgcccgt caatatcaag cgtatatcct gctgatccgt ttggagagta 2660221 aatgatatat ccgtctcaat cgtgccgaga caatcatttc ccaggaaaac ttcgtattgg 2660281 ccgccggatt cctttctttt aagagaaatc actccgctat taaatggaat ggtgctgatc 2660341 gtaacagaat ccttcacatc aggccctatg gtcaccggat gagacgacgg gaggttagac 2660401 agatttaatt tttgaacgtt attttggtaa aaaacccata atagactcaa atggcgaacc 2660461 cccttacggc cgaatggcag catgcgatga cctgcgcttc atgtctcacg ttatttgtca 2660521 tcttttttct catctttctt ttctgtttct tttttctcgt cttctttttc cttctgttct 2660581 tcttttttcg ctttttcctc ggctgcggct ttttcttctg ccgctttctc ttctgcttgt 2660641 ttttcttcgt ctgtttgtgt ctgttcttcg cttgtatcga ctaacgatgt ttcagaatta 2660701 gactgtttat tttcttgacg ttctttttgg gctttttcaa gctcactatt tactgaatca 2660761 agttcttttt gtatgtcttc atcatttgta tcctcagata aaagctgctg tttatattta 2660821 gctagggcaa agtaaatata atcattgtat tccagcttac ggccgatact gatcgcttct 2660881 ttgtattctc ctcgaccata atcaatccaa tataagaaat gctgagggtc tgattgaagg 2660941 gtgactaaat tattttctat atttttggtt tttgcactcc ccaggttttc gacctcaaca 2661001 taggacgtcg ccagctgata ctgcaccgat tcaggcaggc tttccgcatc gtacttggac 2661061 agtgtgctga tgacttcact gtactgcttg tttaagaacg cacggttgct gtccactatc 2661121 gcctggtgct ttggctgcgc gaaaaataag gcgtacatcg aataaataag tgccggtaca 2661181 agcaaaacaa tgagccccag gccgatatat cgctggatgt tccacttctt tctcgggata 2661241 tgtatgtatg tttttgcttt ggcttcgagc tcatcaatat gggtttgaat cagctcgagc 2661301 aaatcatcat aggattcagc atctaatatc gcctttgcct ctgcggagaa cgtcagcgtt 2661361 tcattgaatt tcaggtagtc ttcaaacgca aaagcgccgt caactgccaa agccgctgcc 2661421 gctttcagct cctgccatac tctttcctca tcacgctcgt aaggaggaat gctttctttt 2661481 actccataat ggagaaaata aggcgtaagc cctttatcga atacaatgtt ttcaggagcg 2661541 acaatcaaat tcagcctcga cagattgtgc tgctgtacgg cttgaacaag ctgataggca 2661601 aactgccatt tacttttttt atccttagct ttcatgaagc ggaatgcttt ataggaggag 2661661 ggaggttgga ttgtgatgat tacttcatca tccgtcacat cgatttcttt atgaaaaaat 2661721 ggatttatat ctttgatcac gttagcttca agaccgtcga gaagctttat tttttcccgt 2661781 tgaaaggtaa atgtatagcc ggcatctgtt ttctcggcaa cagcttctaa ttggttttct 2661841 aaatatgatt tttgttcacc tgacattcaa ccagatcctt tcataatatt tcaagccggt 2661901 ctccgtttgt aatgccgcaa tcagacagct tgcattctcc ggaaaacacc ttatccttgt 2661961 tcaccactct gatccagtgc ccttcgcgcg gaggcataga tacgctttgg gcctgccaag 2662021 caatatcaat tacttttttc accgggtggt aatctgacaa tctgagatca aagacactgc 2662081 cgttataatg tttcaaatct attgtaatat caatatacat ttaggatcac ccttacatag 2662141 aaagagcgcc gtcttctttt gaatcaggcg ctccttccct ttcatactgt tatccgcgga 2662201 tttgatttgc gatgtcttgg tcagtagact caagtgtatt tgctgtttga tcaagctgct 2662261 gattcacatc ttgaagcaaa tctgacattt tgataaatga aggtttgagc tgctcgtatt 2662321 gatctgcgaa cgcttcgctt gaagcacctt cccacatgct tttcaaatca gagatcattc 2662381 ggtttaaacg atcaacctga tttaatactt cttggctttc aacgccgtat tgcttcgcca 2662441 tcgctcttag ctcttcgggt gtgacacgaa ttaatcctgc catattcctc attacctcct 2662501 gtgccatcag cctaaatatg ggctaattca cttattttta gaacgtcatt attataaaaa 2662561 cagtttttcg gcatagtcaa acaaatatgt tttaatttta caaaatgagt ccaatggttt 2662621 accccgaatc actcaaaaat gacatatact gtaaagtaaa taggtttatt ttcttaatct 2662681 tctcttcatt ctccgaataa tccaaaagac ccaaataact ctccaactcc caaaaaaaac 2662741 ctttcagaaa atttgatgct acagcaccat ttctgaaagg ttcagttttt tctttcctta 2662801 attagtcttg cctccgatga ctttcttaga agattaatag gataagctgt cgtattatat 2662861 gagacataca ctgtcctgca aaaaggcgat tacaccgcca aatgtatata gaacgtttct 2662921 ctcatgaaat tgtttttttg cttctgttct ttgttgttga ttttcacaaa caacaacaat 2662981 cataataaaa ggaaggggat gagatgtcaa agagaaatca agcacgaaaa gtagggagat 2663041 ttatgaccat gccgaatgat ccgtttaaat atagttttga cagacttgaa gatgtggctg 2663101 atcatatcag cgacgttctg cggtgcccga tcaccataga ggatgttaac cacaagctgc 2663161 ttgcctacag tacacacagc gactgcacag accctgcccg gacgtctacc attattggca 2663221 gaagggtacc ggagaaggtg attaacaagc tgtggaaaga cgggacaatt cctgctctct 2663281 taaaaacgga ccagccgatc agagtcaagc aaatcgatga agtcgggctg agcaatcgcg 2663341 tcgctatttc gatttggaaa aacaagcaag tacttggctt catatgggcg cttgagatcc 2663401 aaaaaacatt gtccgatgaa gatctgctga cattgcaaat ggcagcaaaa gcagtgaaaa 2663461 acaagcttct caaacttcaa atcagaaaaa cgaaaaatga agaacgcagc caagaatttt 2663521 tctggaaaat gctgaccgga cacatccatc aggaggatga tatggcggat gggttccata 2663581 agcttggaat ggccgctcct tcagagtttt ccgttatgat catccgcata aatggcgagc 2663641 tgactgaaaa aatcgaacag cagctgcaat atttacagga aacgacccag caggtttacg 2663701 tgctgctggc gaccgtagat tccaatgaac ttattatatt aacctcaccc aaaacagatc 2663761 atccttttca agatttaaaa cagtttgctt taagtacgca aaaacagctg aaggagcggt 2663821 ataaaataga agacgtttct atcgcttttg gcggaatata caactctatt tcttttgtct 2663881 cccgctccta tcaggaagca ttgtccgtct taaaaacgaa ggaacggttc gctgaagaga 2663941 ccaaacatct tttcagcttt tctgagttag gcatttatca atacttagat gtcttaaatg 2664001 aaaaacggaa acaggcgggc cattataatt actcgctttc caaactggaa caatatgacc 2664061 gggatcacca gtcaaatatg gtagagacgc tagagcgctt tattgaagcg gacagcaacg 2664121 tgaataccgc ttccaagctg ttaaatatac acgttaatac gttgaattac cgactcaagc 2664181 ggatcagcca gatcgctgaa attgatttga aaaatgtgaa tcaaaaattc accatctatt 2664241 tagatatcaa acttcggcac atggatttgt gaaatttcac aaatccatgt ttttttattt 2664301 tcttaatcaa acaaagaatt ttccaaaata tcaagctaca ctaaaaatat cacatataca 2664361 ggaggagaca gatatgatca taggggttcc taaagagata aaaaacaatg aaaaccgtgt 2664421 cgcattaaca cccgggggcg tttctcagct catttcaaac ggccaccggg tgctggttga 2664481 aacaggcgcg ggccttggaa gcggatttga aaatgaagcc tatgagtcag caggagcgga 2664541 aatcattgct gatccgaagc aggtctggga cgccgaaatg gtcatgaaag taaaagaacc 2664601 gctgccggaa gaatatgttt attttcgcaa aggacttgtg ctgtttacgt accttcattt 2664661 agcagctgag cctgagcttg cacaggcctt gaaggataaa ggagtaactg ccatcgcata 2664721 tgaaacggtc agtgaaggcc ggacattgcc tcttctgacg ccaatgtcag aggttgcggg 2664781 cagaatggca gcgcaaatcg gcgctcaatt cttagaaaag cctaaaggcg gaaaaggcat 2664841 tctgcttgcc ggggtgcctg gcgtttcccg cggaaaagta acaattatcg gaggaggcgt 2664901 tgtcgggaca aacgcggcga aaatggctgt cggcctcggt gcagatgtga cgatcattga 2664961 cttaaacgca gaccgcttgc gccagcttga tgacatcttc ggccatcaga ttaaaacgtt 2665021 aatttctaat ccggtcaata ttgctgatgc tgtggcggaa gcggatctcc tcatttgcgc 2665081 ggtattaatt ccgggtgcta aagctccgac tcttgtcact gaggaaatgg taaaacaaat 2665141 gaaacccggt tcagttattg ttgatgtagc gatcgaccaa ggcggcatcg tcgaaactgt 2665201 cgaccatatc acaacacatg atcagccaac atatgaaaaa cacggggttg tgcattatgc 2665261 tgtagcgaac atgccaggcg cagtccctcg tacatcaaca atcgccctga ctaacgttac 2665321 tgttccatac gcgctgcaaa tcgcgaacaa aggggcagta aaagcgctcg cagacaatac 2665381 ggcactgaga gcgggtttaa acaccgcaaa cggacacgtg acctatgaag ctgtagcaag 2665441 agatctaggc tatgagtatg ttcctgccga gaaagcttta caggatgaat catctgtggc 2665501 gggtgcttaa ttcacaataa gcttgcagaa agatttctgc aggctttttt attttttaaa 2665561 aggaaaaaag agaccatttc acgaattatg actatgaagt tgatcataaa ggaggattca 2665621 tatggctgtt cagcaatatg gcgtgttaaa aggcatagta ttagacatga agcgggaaac 2665681 agatgatgac agtcctcatt tccaagtcaa aatgctcggt gaagagaata cgtattacag 2665741 gtgcgccatc aatgtgatgt ccagttctga ggaatctgaa gtattgtatt tggctgacga 2665801 tcagtttgat tcgggctcaa ttaccatcct tccgaacatg ccgtatggat atacaaggat 2665861 caatgaagca aaccgtgaag tggcactgga ttatgtgcgg ggcaatttgt ttgacccgcg 2665921 ggaaatgaag cctttgcctc atgaaatcac gggacctgat aatgatttaa atgattttat 2665981 tgaaacctat atgaagaaag cacaagatga gaaaacgccg gtttatatat tcggttcaaa 2666041 attcggccct gaacaggctg cagataaaat attcggcttt accccgacta acggaatgca 2666101 caatatccat atgaatcaag ggaatgcaat ggatacccgc tggaaaaaag acaacggctc 2666161 ttggcatgac gggggtattc tgattcagtt tgcagatcag tgggccgctg tgtttttagc 2666221 gtttttatcc caatcttggt gtaccgatga aaacggaaac cctgtcagag attgtgatca 2666281 tacccaaacg tctgcgtaag atagaaaaag agactgcggc aagcagtctc tttttgataa 2666341 gattacacat tttcaacagt ctttaggctg tttggcctca tatcgctcca atgcgattgg 2666401 atatagtcca aacaagcttc acgccctttt tgctcatgaa cgactgtcca gccgctcggc 2666461 acatctataa aacccggcca tagggaatat tggccttctt cattgaccag caccaaatat 2666521 gtgccatccg cattttcaaa aggatttgcc attctatttc tcctccctta tttattcaac 2666581 tcttccaatt tgacagcgag aaccttgccg atttgagcca gaggttcagg ctgacataaa 2666641 tctttatgac ggcagtcgat gtcgatttgt tcaatctgtc cgttaatata aggcttccac 2666701 gagtcaggtt caatcgggtc aaaccattca ggaatgattg ttgatctgaa aaacaaaaca 2666761 tttccgcgga aggttttcgg cttataggaa cctaaaatgc cgacagaatt tacatacgta 2666821 ttcttcaaat ttaaaatgac cgtttcatcc aggctcgcaa gcgcactgcc gtcacggcga 2666881 agaatctcaa tcgccgcttc aaaatctagc ggtttttccc ctaagctgtc tggatcatac 2666941 ccgcctaacg ccagaagggc aataagcgct tcctcatcat ccggtgcctc ttttatagga 2667001 aggaagtggt tcggataggc gtccagcatc accaacaggg atacttcttc tccttgattt 2667061 tgcagctggg tagccatcgc ttgaacgaca ttcccgccca gggaccagcc cagcagatgg 2667121 tacgggcctt ttggctggac cgttcggatt tgtttaatgt aatcggcagc catgtcatca 2667181 agtgttttcg gaagctcctc gcgctgcccg attccccgtg cctgcaagcc gtagatcgga 2667241 taatctgttc ctatattggt catcaaaccg gcataacacc agctgagccc ccctgccgga 2667301 tgaacacaga ataaaggagg cttgtctccg cttgttcgga gcggcagcag aacgtcaaga 2667361 gcgctttggc ttgatcccat ttcaagtctt tcagcgagcc cggctacagt aggtgcttcg 2667421 aacaagttgc cgatgctgag ttcaacgccg agcgcttcac gaatgcggct catgagctgt 2667481 acagcaagca aggaatgtcc gcctaaatca aagaaacggt catcaatgcc gacacgcggc 2667541 aagtgaagca cctccataaa gaggtcacag agaatttctt cctgcggcgt tctcggtcct 2667601 cgtcctgtca ctgccgctgc gaaatccgga gcgggcagcg ctttacgatc aagctttcca 2667661 ttcggtgtca gcggcaattc tttcatcgtc acaaaggcag caggcaccat gtaatccggc 2667721 agtctctcag cagcatatct gcgcagttcc gccgtatcaa atgtttcttc cgaagggatg 2667781 acataagctg ctaaccgttt atctcccggc tgatcctcac gaacgatcac tgccgcatct 2667841 tcaagctgcg gatgctgaac aagcgcggct tcaatttctc ccaattcaat ccggaatccc 2667901 cgaattttca cttgatggtc tgcacggccg acatagtcga gagaaccgtc agcgcggagg 2667961 cgggccacat ccccagtgcg gtacatccgg gtgcctggag gaccgaacgg atcagctatg 2668021 aagcgttcag atgttaaacc aggccggcct agataacctc gtgctaaccc cgctcctgat 2668081 acatacagct ctccggcaac acccggcggg accggctgca ggcgttcatc cagcacgtat 2668141 acaccaagat cgggaatgcc gcagccgatc aagctgtttg cccgtaaagc tgccatgctt 2668201 cggtctaatt cgatatagct cacatgcacc gtcgtttctg taataccata catattgata 2668261 agctgcggtc tattttcagg gtggcggttg taccaatcct ctaaacggct gagttcaagc 2668321 gcttctccgc caaaaatgac atagcgcaga ctgagtgcct gtccgagatc cggctgttcc 2668381 cgttccgcct gcataaactg atagaaagca gacggtgtct ggttcagaac agtcaccccc 2668441 tctttgacaa gcaggcgcag aaacgcttct ggcgatctgc tgacgtggtg aggcacgatt 2668501 acaagacgtc cgccatgcag cagaggaccc cagatctccc acaccgaaaa atcaaacgca 2668561 taggaatgga acatggtcca gatatcacct gagctgaaac ggaaccagtg ctcggtcgct 2668621 gcaaataaac gtgttacatt ttggtgagga atcatcacac cttttggaac acctgttgag 2668681 ccggatgtat aaatgacata tgccgtattc aaaggggaaa gcggctgagt cctatcctta 2668741 ttttttggat tacctgcagg gtacgtgttt agtttctctg ccagctcggg atcatccagc 2668801 acgattttcg gcacgttttc aactggcgga atgtgatttg cagctttagt gttcgtcatg 2668861 ataaacgcag gctgtgcatc ttttagcata aaagcaattc gatcagccgg ataatccgga 2668921 tcaagaggga gataagctgc cccggccttt agcaccgcca ataggccgac agccatttcc 2668981 aacgatcggg gcagtgccaa tgccacaaat tgctccggcc cgacaccttc actaatcatc 2669041 attcgggcaa gccggtttgc tctttcattc agctctgcat agctcagttc ctgattttca 2669101 tatacaacgg caatggcatc aggacgtaaa gcagcctgct tctcaaattg ctctggcaaa 2669161 catgcgtgcg gaatcttttc agatacactt tgccaatcag tcaccatgct gctgtgttcc 2669221 tctggcgcaa gaatatccag atttccgatt tgctcgtcag gatcagactc ggcagcctcc 2669281 aacaggcgca tcaatcggtc agcaagagcc tgagcagttt cccgtttgaa aagatcagtg 2669341 ctgtattcaa gcagtccttc cattccgttt ggtgtcccgt cagcaaggcg atcttcacta 2669401 atttccagcg tcaaatcaaa cttggcagaa ccgacactgt tgattcgcag gctgctctcc 2669461 atatcaggaa gatgcagttc agcgtccggt gtgttttgga acgcaagcat gatttggaat 2669521 aaaggatgcg tcgcacgcga acgagccgga ttgagcacct ctacaagtct ctcaaacggc 2669581 agatcctgat tgtcataggc ggccagattc acttcccgta ctctgtctag aagctcacga 2669641 aagcttgggt caccggacgt atcagttctg agcaccaatg tattaatgaa cagccctaca 2669701 agatcgccca gcgcatcatc attccgtccc gcgatcggac tgccgatcgg aatgtcggtg 2669761 cccgccccga gccttgtcaa taaagcggcg agaccggatt gaagcaccat aaacaggctc 2669821 accctatttg cgcgagccag ctcctgcaat cgcttgtgaa actcgggctc aatacgaaaa 2669881 tgaatcgtat ctccatcatg actcggctca gccggacgtg aataatcggt tggcagttca 2669941 agctgatcag gcaggttttt caaggtttct ttccagaaag caagctgtcc ggcaatcaag 2670001 ctatttggat catcctcgtt tccaagcagt tcttgctgcc aaagcgcata gtctgcatac 2670061 tgcacagcaa gaggcgccca ttcgggagat cgtccgtggc agcgagccgc ataagctgtc 2670121 ccaaggtctc tggtcagcgg tgttaaggac cagccgtccc cgacaatatg atggacgaga 2670181 agaagcagca cgtactcgtc aggaccgatc acaaaaagct cggcacgaaa agcaggttca 2670241 gctgcaagat caaagctgta gcgtacagct tcggcaagcc gatcagaaag ctccttctca 2670301 gcaatttcag taacatgtaa ctcgggacag gctcgatcgg catctaaaat atgctgatag 2670361 gatgtcccct gtgattcagg gaagatcgtc cgaagacttt catgacggca gacgaggtca 2670421 taaagtgccg ctttcagcaa tccttgatcc aactcacctg acaaacggac agcaaccgga 2670481 atattataag taggactcgg tccttccaga caatgcagga accatagccg gcgctgggca 2670541 aatgagagcg ggatcttttc aggccgctca gctctctgca aagcgggaca tgcactctgc 2670601 gccaaatcaa gatgggcagc gagtccggct actgtcggtt cgtcaaagag cttggcgata 2670661 ccaagttcgg ctcccattac ctcgcgaatg cggctcatca gacgggctgc aagaagagaa 2670721 tggcccccaa gctcgaagaa actgtcatcg ataccgacgc gtgccaaacc gagaacctct 2670781 gcaaacaagt cacacaatat ctcttcctga ggagtccgcg gggcccgatc actgacagat 2670841 gtgctgaagt ctggtgccgg cagtgctttc cggtcaagct tgccattagg tgttaacggc 2670901 agctcgtcca tctccacaaa cgccgacggt accatataat caggaagact agcccccata 2670961 taacgacgaa gctctgcagt atcaatagca gcatcagcga ctacataagc cgccaatcgt 2671021 ttgtctcccg gctgatcttc ccgtacgaca accgcggcct gttcaatgtg cgggtgattg 2671081 gcaagcacgg catcaatttc tccaagttca attcggaatc cgcgaatttt gatttgatga 2671141 tccgcccgcc cgatataatc caaagaccca tcggcgcgcc agcgggcctg gtctccggtc 2671201 cgatacatcc gagttcccgg cggtccgtat ggatctgcaa cgaagcgctc cgccgttaaa 2671261 tcaggacgat ggaaataacc tctggccaag ccggttcctg caatataaag ctctccgaca 2671321 acgcccggcg gcaccggctg caatccatta tcaagcacat acacctgcgt gttccaaatc 2671381 ggtttcccaa tcggaggaac gcccttcagc ccttcttcaa gaaaagctgc ggcagaccaa 2671441 atcgttgttt cagtgggacc gtataagttc gtgactgaac aatgaaggtc ttgaagttcc 2671501 tgcaaaagac cgctcggcag cgcctcgcct cctacaagca ctctaagccc ccgaagtttc 2671561 tcaggttcac tcgttaccaa agcgtgccac agtgtcggtg tcgcctgcat aatgttaata 2671621 tcgaaatttt caatcatttg agctaatgcc tgcggctcac ggatcgtttc tttctttgcg 2671681 atcacgattt gcgctccgct aatcagcgga agatataact ccaatgctga aatatcaaaa 2671741 gcgacagtcg tcacagccaa cagcctgtct tcttctccta gagaaaatgc ctcctgcata 2671801 gacagcagaa aattgcttaa gcttttctgt gtcacaacga ctcccttcgg tcttcctgtt 2671861 gatcctgagg tatagatgat atacgcagga tggtcaagcg aaaccgatac atcctgattt 2671921 tccggcgaat agcgttttat aatctcctgt gtaacagcct gatcaagcac aagctcaggt 2671981 acagccaggt catcaggcag actggctgct atttcctcag tcgttatgat gcatgaaggt 2672041 ttcgcatcct ccagcatgta agaaatgcgg tcggctggaa actccggatc aagggggaga 2672101 tacgccgcac cagtcttgag cacaccaagc attgaagcca ccatctcagg ggaacgcggc 2672161 agcgccaaag cgacaaattg ctccggacca atcccttttt cgatcaacag acgcgcgagg 2672221 cggtttgcct cttcattgag ctttcgatag ttgacttgaa tgtcatcaca catgagagcg 2672281 atacgttctg gcgtaagaac tgcctgcttt tcgaacatgt cctgaaggct gaccagcttc 2672341 tcggattttg ccgtctcatt ccatttagaa atgacttttt ctttctcctc tggcaacaga 2672401 agctccattt gcccaatcag catgtcctct ccggcagaag ccgtttgcag cagctgcaaa 2672461 atacgctgct gatgaagctt aatatcagac tcactgtata cctcgggatt cgcatcaaca 2672521 tcaattcgca gcccgctgcc gtctgttctg tcatatacat tgattgatag atcatcaaca 2672581 ggaccggctg aaagattatg cgttgtgccc cggacgccgg caaagtcgag accgtaatca 2672641 aacggcataa gattgatttg agggccaaat aatctatgat tttctcctat caatttcaga 2672701 tcgcgcctaa gctcttcatg gcgatactta tgatgtcgcc gaatactgcg gatttcccgg 2672761 gaaatttgct gaatcagttc agaaaagctc atcgaagagc ttaccgtcag ccggagcggg 2672821 agaaggttca tcaccatagc cggtacattc agtgacgcgg accctatccg acccatcatg 2672881 ggcaggccga gcacaacatc ctcagagccg gtcatacggt gcacataaac agctgacacc 2672941 gcaatcatga cttcatgcca gcttcctgag aaatagcgcg ccgcttcttt taacgcgttt 2673001 acatcagacg gaggcagata tgccgtatga cgaagaaaac tgttagatgt tcttggcgcc 2673061 cgatcagcca agctcacaac ttcaggtgca tctgcaaaac ggtccagcca gaattgacga 2673121 tccttctcat actgctctga tccgcgataa tctgtatcct cctccaaaat ggcctggaga 2673181 gacccaaagg aacggctttt agctgtttgt ccttttataa gggcagtata tgtacttgcc 2673241 acacgctggg ctatcaggga aaaaccgaag ccgtcgatcg ctatatggtg aatgcgctga 2673301 taccaaaaga aacgatcagg cccggcaata aacagagctt cattgaacaa aggggcatac 2673361 cctaaatcaa ccggctttgc taaatcagct ttcatccagt ttaatgctgt tttttccgga 2673421 tcaggctcag agctgacgtc aatgacgtgc agctgtacat ccggagacgg gtttatcatc 2673481 tgccaaggcc cgtccatatt ttcaccgaag cggacatgca gcgattccgc ttccttgatc 2673541 acgtgccgca aagcttcttc aaaaagagca atattgactg gtccattgat ttctatatat 2673601 tccgctgtat tgtagattgg attgtccgga tcaagctgct gagcaaacca tatgccagtt 2673661 tgcgccccgg tcaaagaata ttgaagatct tttgtatcag gcatccgttt gtttaccctc 2673721 cttttataaa taatccgcgt ttggcagcac ttgctggctg cgagttgtga gcaatttctg 2673781 ccattcttcg atcgttgggc gttcagccaa ttccacgaaa gtcacctctg ccccttcacg 2673841 gcgccattgt tccaccaatg tcatgatcct taccgaatca agaccacgat cgagcaaatc 2673901 ctcttgatct gtgatgtctt ccggtgtttc ttgtagaagc tcagcaattt gtttacggat 2673961 attctcacat gtaaacacgt tctttttgcc agtgtttgct gacgtttttt gaacgtctgc 2674021 cggcgcattc tgcagctgat caagaagact gtcagtcatc acggtaaacg cacagcgtcc 2674081 agccgcatat tccagcgcca tttgatgttt ttctaatgaa aaatcagcaa ctgcatctcc 2674141 cacaaaaaag gctttaatat cctccataaa tgcttcacat gctgtaacaa gacagccgat 2674201 atgggcgtaa attcctgtaa tgatcagctg atcgcgtccc tctttgcgca tcatttcaag 2674261 cagattcgtt ctcttaaacg cgctgtatct ccattttgtc agcacaagat catcatcctc 2674321 tggtgccagc tcggttataa ttttctcctc ataaggaccg ctgtttaatc ccgggcccca 2674381 aaagtctgtc agcagcgcac ggtcatccgg attttggctt cccggctgtg cggtatagac 2674441 aacaggaatc ccaagctgaa cacattgatt cttcagcttt cgtatattcg ctgaaagctc 2674501 tgttaccgga gacgctcccg ctgtgaaagc atcaacaaaa tagttttgca tatcgtgtat 2674561 taacaagaca gcccgattcg gatcaggcac ccatgatact ttgttttgcg gcatatcaga 2674621 tgctgtcggc atttgatacg gctgaatggc aggtatagcc atatgaacac ttcctctcaa 2674681 attgttgttt tattttttaa atcctgcaag aagcttctcg gaaatggctt cacggagcgc 2674741 ttttttgctg acttttccta ctcctgtctg cgggaaggat tcgacaaatt caactcgatc 2674801 agggatttta tatgccgcca gtccgcgctc tctcaaaaat gctttaagct ctgcggcttt 2674861 tggggcttca tcccggggaa taatgaacac acaagatctt tcgccaagaa attgatcagg 2674921 catggagacc attgccgcat catggacagc cggatgcgcc agcagatgat tttctacctc 2674981 ttcagccgca accttttctc ctccacggtt aatttgatcc ttcgcccggc cttcaacgac 2675041 aatatagccg tctcgtgtca gcctgacgat atcacccgta cggtaaaaac cgtcctcagt 2675101 aaatgaagcg gcgttatgct cttctgcctt atagtaacct cgaattgtat acggcccccg 2675161 cgtcagcaga tggcctgttt caccaggttt tacgtcgcga tcatgatcat cccaaacacg 2675221 catttcatca tatggagaca tcggttttcc ttgggtgttg acaatgatct cctcaggatc 2675281 atccaatctc gtataattga cgagaccctc tgccattccg aacacctgct gcagcgtgca 2675341 gccgaaaaca gcttttaccc tgcgcgcggc ttcagcacta aacttggcac cgccgacctg 2675401 cagcacttga aggctggata aatcatcacg gcgtgaggat gccgcatcca tccataccat 2675461 cgcaagaggc ggaacaagag cggttatcgt gaccttttcc cgttcaatta aaggaaatgc 2675521 gtcatctgga cttggagaag gagataatac cactcttcct ccagcgtata atacgccgag 2675581 aacgccgggt gagctcagcg gataattgtg tgccatcggc agcgcggcca agtacaccgt 2675641 gctgtggtcg agccagcaga cctccacact ccgcttcagg ctgtatatgt agtcatcgtg 2675701 ggtcctcgga atcagtttcg atagcccggt gctcccgcca gaaagctgga ggaacgccac 2675761 atccgatgat ttgacttcag gcagttttac aggttctgca tgcaaatcct ccagcggtaa 2675821 aaattcctct gcctcacctg cgacaatgat gtttttcaaa gtcggcagct tgctttgaac 2675881 ctgtctggca agcgaacggt agtcaaaacc ggaataagcg tcgggaatga tatatgcagc 2675941 cgcttcagca aactcgcaaa aatatgtaat ttcactgctt cgatgagaag gcagtgcgaa 2676001 gactggaagc gcccccagac ggaaaagcgc gaaaatgact tcaaaaaact ctttgatatt 2676061 tggcaactgc accacaacac gatccatctg ttgaatgccg agcttttgaa atccggcagc 2676121 caggcgatca gcccttgtgt caagctctcg atagctccaa tgggtgtttc cgcatgtaat 2676181 ggcaatgcga tcaccatatt tggctgcccg gtcccttaac aaatctccaa acgtctcacc 2676241 ggcccagcag ccgttctttc gataggtctc agctaactca tcaggccaag gcgtaaatcc 2676301 tttcagcatg ttgtatccct ccagcaattc attctgttca tatgtgatcc acgcccattg 2676361 cccgcagcat tgtccgaaac tttgcggacg tctcctgaag ctcgtcctca ggctttgaac 2676421 cggccacaac accagctcca gcatacaggc ggagtgagcg ttcttctgct tctgcacaac 2676481 ggatggtcac gatccattct ccgtcaccgg catcgtcaca ccatccgacc atgccggtaa 2676541 agaaaccgcg gtcaaatggt tcaatgctga gaatcgcttc tcttgcaaga tcagtcggtg 2676601 ttccgcagac ggctggcgtc gggtggagcg ccgccgccaa ttcaagtgcg gttacagacg 2676661 ggtcggaaag ctctccctta atcacgctgg acaggtgcca catcgtttcc gttttgatca 2676721 gtgaaggctt ctccggaacc tccagcgtcc ggcagaaagg tctcagcgct gccgcaaccg 2676781 cgtcagcgac aaccgcgtgc tcatgaagat cctttgcgga agaaagcaat tcagctgccc 2676841 ggcgctggtc ttcaacagga tcattactgc gcggtcttga gccggctaat gggttggaaa 2676901 cgacctgtgt tcccatcctt gaaacgagaa gctccggact tgctccgagc aatgttctgc 2676961 ggggagacgt ttcctcctga ctggacacgt ctgcggcaaa cgtgtagcca tgcgagttat 2677021 gctgagccag atggcgaagc aattcatccg tctgaatcgg ttcaggcgat gtcaaatgca 2677081 gcgatctgga caggacgatt ttgctgagtg ttccatcggc aatgcgtgcc agcccttgtt 2677141 caacaccatt tttataatcc tcaggttcag gaacaggctt tatgtggtat gtatgcccag 2677201 cctgctgttc cttttcctca tgatcaaatt gaagcggtcc tgaccagcgc acttcttcag 2677261 gtacaacgag ccgcgctgct tttacttgat caaaaggaac ggccccgaca acaagcggcc 2677321 ggctttgccc tgattgtttt gcctgacgta acgcctctgc aattcggcca gaaagggttt 2677381 ccatttggtt ttgcccgtct gcctccggta caatttcaca tatgcctttc gctaacagta 2677441 cacgatgagg agacgctaag aaaaaggcgc ccggctgata ttcatgaagc aaatgctccg 2677501 cttttgtttc tgttataacg ttttgatcca acattctcat gaacctcctt taaattcagt 2677561 tacacgccta aggtcgcgcc gccatctacg cataaattat gcatcgtaat atgccctgcc 2677621 tggccagaaa ccaaaaagag caccgcatcc gcaatatccg aaggcttggc tagttttttg 2677681 agcgggatcc ctgttttaaa tgtctcaagt gatcctttta tgacttgctc cgctccattc 2677741 tcgtcggccc ataatgacca ctgcatgtct gtttccgttg atccgggaga tacaatgttg 2677801 cagcgaatat tgtattctgc aagctcaagg ccaaggcatt tcgtaaacat cacagccgca 2677861 gcctttgaag acgcatatgc cgccatagat gttcttggta caccggcagc attcgatccg 2677921 actgttacaa tcgaacccga tcttcggtcc atcatatatt tgctgactga acgcgaggcg 2677981 ttaaatacgc cagtcgaatt cactgagaac gtcgcctccc attcctcatc gctaagcgaa 2678041 tggatcagtc ccgggcgaag gacacccgct acattcacta aaatatcaat cggccccatt 2678101 tcacgttcga tgcgcgccgt gatctcgtca atcgccgcgc tgtctctcac atccgcagga 2678161 aaagcttctg catggcggcc ttctgctttg aggctgctca caaccttttc cagcttttca 2678221 ggattataat caactgccgc aatatgtgcg ccttgactgg caagcgtccg cgcaacagct 2678281 tcgcctattc cttgggcagc ccctgttata aaagcaattt ttccctctat accctttgca 2678341 ttcatatcat caattccttt cttcgctcta aatgccaaac agacatccag cgaaaaagac 2678401 tgctgcgcct tgaaaaacgc aatctattga taatgattat cattatcaat tataaaaata 2678461 atcatatcca aatgtcatgt gacagtcaaa tataatttca gtgacaaata tttttttaaa 2678521 ggcaaggctg agtatgtctc agcccattga tagatgcggt ccgtcagggt gaagcgcaaa 2678581 acgcagcgcc ctgctgacca aaacaggaag aactgaaata tgtccttctc ctgaaaactc 2678641 gcaaaattct gcccgtatac cttgttcaga taaaacggcc agccgctcat aaagctccct 2678701 tgcattatca ttcatccggc ttttatgatg ctgctctaat tctcctgcgg caagcaggat 2678761 attgataggc tgattgtttt tcttggtgag agagacgaaa tggtccgttt tcttgagaat 2678821 aaacggttta ttccaatgaa tggacggact tcccgcgata tacgtttgaa acgcatcggg 2678881 ctttgttagc agcacctgca gcacgaaaag ccctccgagc gaatggccaa agattgtttg 2678941 tcttttttta tcaatctggt aatctcgttc tatctccggt tttaaatcct cttcaataaa 2679001 tctgaaaaag ccctccgctc cgccatgctc cggccattct ctgccgtcgg gcctttccgg 2679061 cagcttcgat tgggctgttg gcattgtaaa atcccggtgg cgtgctgagg agaacggctc 2679121 cgctgtctca tagccaatgc cgacgatcac tgcagggatc accccggttt tttcgggtcg 2679181 gcgtccctgt attcgaacgg cttccgtcat cgttccgaag acagaattgg catccagcag 2679241 ataaatcaca ggataaccag cgggtggcgg cggcgtacta ggtttcgaga taaaaatgtg 2679301 ataggtacgg ttttcattgc gtgaagacat catacgcact tccgtaccag gaatcgtaaa 2679361 tgcgtttgat gtcccgccat ttgtccggtc tgttgtttgt tctttcatgc agtacgacat 2679421 tcctctcctt aaactaaacc gcaatgtatg ataatgattt tcactatcaa ctagacacct 2679481 caaataatag gttttcttcc aaagaaagtc aactttttcc cgaataaaaa aggcaccttg 2679541 atcaaataag gtacctgcag actatcaata tggaagtaaa aacctaataa agatgcgtat 2679601 tgtcctattt gaaatagaac cttaatccca tgtaaacctt tgattttgcc aagggtcgcc 2679661 tctcatgtga tagccattcc gctcccaaaa gccagggtga ttttctttcg taaattggat 2679721 gccgcgcagc cacttggcgc ttttccaaaa atacagatgc ggaaatacac cccgcagcgg 2679781 aaagccgtgt tcaggggtta aaggttcgcc attatgcgca taagccagaa gggaagtttc 2679841 cgctaagaaa tcatcaagcg gcagattggt cgtccagccc tcttcagcat gtaaaatgac 2679901 gtagcccgct tcttctttta cacccgcttt ttccgctata tcacaagccc gcacgccttg 2679961 ccacacatta tcaagccttg accatcccgt gacgcaatga atgtcgtttt tcgattcata 2680021 ccgtggaaag gctttgacat cttcaaagct tagcagcatc ggatggtcaa ccaaaccgta 2680081 tacttgaaga ttccatttcg tcatatcttc gtaatatggg acatctccgg tatgaagcac 2680141 aggaaatgaa gtggtgacgt tttgatttgg cggcactctt ccagattgat cggactgtct 2680201 tgtttttccg aaatacatat gggcctcctt tttgttaacc taatttaaaa tcatgttgac 2680261 aatctttttg ttctttatta ctctatgatt gtgtatgtca acctaagggg gaacaacgat 2680321 gaaacaacgt aaacttcgtg cgggagatat ggcgctgatt ggcatgttcg ccgcacttat 2680381 ggctgtcggg gccaacatta catcagtagc acccttttta caagtagccg gcattccgct 2680441 ttcgatgcag ccgtttttct gtctcttggc agctttgctt cttggcagca aacgggcagc 2680501 gattgccatg attgtatatg cacttgtggg attggccgga gcgcctgtgt ttgctcaatt 2680561 ttcagcaggc ttcgcaccgt ttgcagggaa aagcggcggg tttattatct catacattcc 2680621 ggcagcattt gcagcgggat ggtttttaga acgaaacatt cagccaagta aaattcgatt 2680681 tctcattgct tcacttatcg gaacggcgat catgtatctc atcggcacta cctatatgta 2680741 tcttgcactg aagctgtgga ttcatacgcc agtgagctac ggcacggctt ggggctttat 2680801 gatttggttt atggtaaaag atacagcgct ggctgtgata ctgtcgttta tcgcaccagc 2680861 aatctaccgc tctattcata aagcaaccgg ctttaacaga aatcacatat catctacgta 2680921 aaaaccgttc tattggacgg tttttttatc ataacgagaa aaggctcccc agtaaagggg 2680981 agcctttttc ctataaaaca agcgctgcaa tccagccaaa gatgacaagc ggaatattat 2681041 aaaatataaa tgtcggcaca caagtatccc aaatgtggtg atgctggccg tccgcactca 2681101 aacctgaagt cggcccaagc gtactgtcac tggcaggtga accggcatcg ccaagcgcag 2681161 cagcagcccc gataatcgca atcgttgcca tcgggctgaa tccaagctgc atgcatagag 2681221 gcacgaaaat ggttgtgata acaggaatgg tcgcaaaaga agatccgatc cccattgtaa 2681281 ttaataagcc gacaatgagc atcagcaatg cgcccaagga ctgactgtgt ccgataaaac 2681341 cagctgacgt tttgaccagt gactcgacat ctccggtttt cgtcaatacg tttgaaaatc 2681401 cggctgcaac aagcatgaca aagccgataa aggccattaa aaccattcca tcagtaatca 2681461 gtgagtccgc ttcatcacgc ttcatcacac cgctgacaaa cagaacaatc agaccagcga 2681521 gcgcccccat aatcattcct tctactccca aagtctgaga taagtaaagc tggacgccga 2681581 gtgacacaac aatggctaga accgcgatac caatactttt tctcgtatat ggcgatgctt 2681641 ctgcacctga aatgtctttt gtttcatatt gtttcggttt acggtatacg atcactgata 2681701 aaataaggcc gacaaccata cctgcaactg gaataatcag tgcgtacgga atatcagcaa 2681761 gcggaacgtt taacccggca tccgccatat tgtccttcag catgccttgg aagatttggc 2681821 cgaaaccgac cggaagcaaa atataaggag ccgttaagcc aaatgtaatt acacacgcga 2681881 tcagacggcg gtccatttca agttcattaa agattttcaa aagcggcgga atcagcaccg 2681941 ggataaacgc gatgtgaacc ggaacgacgt tttgcgaaaa acaagataca attaaaataa 2682001 tcagcacaat cagcacctta gacagtgctt tttttcgaga atcttcttta tttccgatta 2682061 atttaacgga ggcttccacc attgcgtccg gaagacccgt tttcgtcaaa gcggcggcaa 2682121 acgcgccaag catggcatag ctaactgcaa cggtggcatt tccgccgaga ccgtctgtga 2682181 aagctttaac cgtttcgcca agaccgagcc cgcctgttaa cccgccggcc aaggcgccta 2682241 taattaatgc gataacaata ttgacacgca gcaggcttaa tacaagcata agcaggactg 2682301 cgatgacgac tgcattcatg atgatacccc tccaaaaatc ctttagtttg ctaatgtagt 2682361 agataaataa agtacgaacg tatcgtatca taaccgatcc actttagtca actaaagatt 2682421 tcggaagaaa aaatccctgc cgcatcatac agcagggatt tttcattact cgtttttatc 2682481 ttcttccaat gtaaatcgct ccgcaagtgt agccagtgtt cttgccataa cgccagtagc 2682541 cccggccggt ccgaagcagg ttgctttatt ggcagtcgct gtgcctgcaa tatcaaggtg 2682601 aacccaaggt gttgactcag cgaattcacc aagaaacgtt cctgccataa tcgcatgtcc 2682661 ctcgcgtccc ggtgaattgc tgagatccgc catttggctg cttttcacgc gttttttatc 2682721 cttctctgtt atcggcagct gccagatcgc ctcgccgcac tcttgtgcag catcagctac 2682781 ctgctggtaa aagctttgat catttgtcat tgcaccggtt gtttctgttc ctaatgccac 2682841 aacgacgccg ccggtaagcg tagctacatc gacaagaact gatgcgccat gctgtttcgc 2682901 gtatgtaatg ccatctgcaa gcactagcct tccttcagca tccgtattaa ggatttctat 2682961 tgtttttccg cttaaagata cgatcacgtc atccggcttc atggccccgc cggagatcat 2683021 attatcggtt gatggaataa cgcacagcac gttttgttca ggacgaagct ctccgatcgt 2683081 ttccatagcc ccgagaaccg cagctgctcc tcccatatct gatttcatgc caacaattcc 2683141 agatttcgtt ttaatggagt agccgcctgt gtcaaaggta attcctttcc cgactagtcc 2683201 gacgacgtct tcccattcct ttttgccctg atatttcaac acaatcattt tcggcggttc 2683261 ggtggagcct tggtttaccg caagtattcc gcccataccg agctcttcca tctctgattt 2683321 ctccaatatc tcacactcaa aatcatattt cgccgcaagc tcttcagcat acgaagcgag 2683381 gtcagtcgct gtcagcatgt ttcccggcat attcacaagc gttctagccg aatttgtccc 2683441 ttgtccgtat gcctggccga cgcgaagccc tgcctgcact tcctgtgtat cttcatctgt 2683501 tacaacatac acggcttcaa tttgtttgtc aggctcattt gatttatgct tataatcctg 2683561 cacctcatag gaagcaagca ggcagctctc agctaaagca tgagcggcat cggctggagg 2683621 cacgtcttcc gaaataaacg tatcaagcag aacagcagtt tcttgttttc gatctttatg 2683681 aatggcttga aaaacatgag caaaacgttc cttcgcctgt tcaaacgaat aatttgcttc 2683741 tctccccagg ccaacgaaat aaatccgttt catacccgca gaagatggag ggaatacttt 2683801 tgatacttga ttcggtttcg cagagacatc accctctttt aaaagctgtg tcagatggcc 2683861 ttcgagcatt tcatcaattt ccaacgcttt tcctgtcagc tggctttttt gaaaaagccc 2683921 gacaacaagg gtttctgtat gctctgattg ttgaaccgca taaaacatga ggcttacact 2683981 cctaacgtaa tgggtatttg taatgaacaa tggtataata ggaaaaacat tctttccact 2684041 atacttattt taacaaacaa cagtctaaga cttgcttttt tcttttgaaa cacgaaggat 2684101 ttttcaaata gaaaggatgt cgccgatgga acttttaacg aattttcctt tattatcaag 2684161 cctggccgca attatttttg ctcaggtcat caaagtgccc atacagttta tcgtgtccag 2684221 aaaactggac tggtcgctgg tcacaagcac aggcggcatg cctagctctc actccgcagc 2684281 ggtcactgcg ctttctacag gcgtagcctt ggagcatgga ttagactcct cactctttgc 2684341 ggtttccgcc attttcgccg tcataaccat gtttgacgca actggcgtca gacgtcacgc 2684401 cggtgagcag gcaacagtca ttaataagct tgttattgat tttaaccgtt tcgtaaatga 2684461 agcgaaggac ttccctaagg ctgcagagaa agaaaagcaa aaaaagctga aagagcttct 2684521 cggacatcag ccgatcgaag tctttttcgg aggattaaca ggtattttac tgacattggt 2684581 actcgcttac tttttcatgt aaaaaaaacg ctcctgcttt cgctggagcg ttttattctt 2684641 tcaccgtttt atattgattt ctgaacactt gcaaagattt tgtttcattg agcttctcaa 2684701 gctcatcctc ggtaatcttt cccgttccct ttttaatcac atatacatca agggtttttt 2684761 tgccccattc attgtataca tctttgactg tctcaaagta cagatcaagg cggtttccct 2684821 taatagctga tcctgtgtcg gccacaactc cgagaccgta gttcggaatg aataaaattg 2684881 ttccgatcgg gaaaacggac gggtcagcag caaccgtgga atataaatcc cgtttcactt 2684941 tcacacctga atatgtaagc ccgtataatg gatcaccggg atttttgccc gtcgactcag 2685001 ctcctgctgt gtagcctgtt gctgttactc tttggactgg atattcatcc caatcaaatg 2685061 cctcttctaa cggttttgtt ttatcctcag ccgcggacgt ggtttgtgtt tgtttctgct 2685121 gcaatgcttt taatctcagt cctgcatgct tcaagtgctt ttcctgatgt tcctgcaccc 2685181 attttgacaa gtccttcgct tcaattcctg acactgataa aaatgtcgtg ccaaatgcaa 2685241 gcagaaataa acaggtcatc agcaaacgtc tgatcatatt caacatcatt cacctctcct 2685301 ccgaatcatt gttcccaagt ggagagagca ttattcaaaa tggtgaatga gctgaacgca 2685361 taaaaaaagc tttctttaga agaaagcggc atttaaaaca tttgatatcc tctttttcta 2685421 agcatgttga tcgctatacc ggacacgatg gcgccggcca aaccgctgac taaaatcagc 2685481 acatcagcag ccgctaatga taagacacga tgaaacaggc tggcaaagga ttctcccggc 2685541 gactggacat agctgatcag cttttctttg ctgataatga aaaggcatac aattggataa 2685601 atcacagcca taatccaaga cattctcagc agcatgttta ataagaaacc gattccaaaa 2685661 aacaagacaa aaaacaaaac aattgagatg attacgactg gcagactaat caacctattc 2685721 cacccccctg cgttgttttt agtgtaacgc gggggctgaa ataaagtcaa cggctggaaa 2685781 aagaatgact gtcttttcct gtcccctggc aagacggaca agtctctgaa ccgccgagaa 2685841 tcaattgaaa atatcctttc cctgaacaaa atgggcatgc atgtgaagcg gttgtcgttg 2685901 cagttttcat ctaatcatca ccctttttct taattttctg ataatatacc atatcaagct 2685961 gtcaacaata aagtcagatc atgtgacaaa tcttttgatg taagcggaaa catacttgtt 2686021 ttcctctcgt tctcttttta ttttggcgtt ttttaataaa gaaaacccgc ttccgcgggt 2686081 ttttagaaaa acttgaactt gccttttttc aatgtcagtc cgagtccgcc aatcataaac 2686141 agtgagcggt tatcaatgac ttttttcata aacgaagcgg gcgtgccttt cagctttctg 2686201 ccataaacaa ccccaaccgc gttatgctcg ccaagagaag ccactgttcc cttaatgtcc 2686261 ggcttgaatt cctcaagctc tccgccttta ataagcctgc caaggttttt agcgaccgtt 2686321 atgccctgct gcattgcaat ttgcgcagtc ggcggatacg ggcgctctgt atcttcattc 2686381 ataaacagcg agctgtcgcc gagaataaag acattgtcat gtcccggggc gcggagatca 2686441 gggttgactt tgactcggcc gcgcatattc tcaaaaccgg cttcctccac aatcggatgg 2686501 ccgcggacac ctgccgccca tacaacggtt tgcgatttga tctgctctgg ttcttcatct 2686561 tttttgccga ctctgactcc ttctggtgta cattcttgta cagccgttcc gatcttgaac 2686621 tcaactccgt tttcctcaag ataatgtacg gcgtaatcaa caagttccgg atcaaagccc 2686681 ggcaaaacgg tcggcgctgc ttccacacaa atgatgcgga caaggcttct gtcaacgtca 2686741 tattccttac agagctccgg cacgcgagca gccagttcgc caagaaattc aattcccgta 2686801 aatccggcac cgccaacaac gatcgttaac ctgtccggcc gtttttccgc ttccgtattg 2686861 taagtcgcaa actgcagctc aatatgttcc cgcagcaggc gcgacgtgtt gatgttggca 2686921 atcggaaacg catattcttt taagccttta atgccgaacg tttcaggcac ggcgccgagc 2686981 ccgatgacta aataatcgta ctgcaattct ccattcgcaa gcacaacttt tttctcatca 2687041 attttgattg cctttacggt atcctgtaca aaattcaccc gtgactggtt gattacatct 2687101 tttatctgat aacggcagcg gtcatgatgg agcgtacccg cgctcgcttc atgcatccat 2687161 gtcgtttcat aatgataatt gtgtttattt acaagcgtaa tgtcagcatc attcggcccg 2687221 acatacttcg tcagccttgt caccgtcatc aatccgccat atcctgcacc taaaatcacg 2687281 attttgggct tattcaatgc catcacatcc accttctctt tttttgcttt tgttagaccc 2687341 ataataaaat catcatttgt gttagcttca gcttattggc gggattttat gaaatatatt 2687401 gaaaagtttt ttgtgaagtc cttacccgta gcactattat catgtttatc cggctggccc 2687461 aagaaacatt cagaaaaaga tcatttcatt tggttattat cgtagcggcc tgcggaaata 2687521 ttttcaagaa cggatgggca cgttagatcc ttacgatttt ttctgctgac tcgtcaattt 2687581 gaacggcaat atggtataat taataacaat tttcatttag gaggcaattt tcgtatgcga 2687641 gaggatacaa aggtttatga tattacaatt ataggcgggg gaccggtcgg cttattcacc 2687701 gctttttacg gcgggatgag acaggcaagc gtcaaaatta tcgaaagcct gcctcagctc 2687761 ggcggacagc ttagcgccct ataccctgag aagtatatat atgatgtagc gggattcccg 2687821 aaaatccgcg cgcaagagct tatcaataac ctaaaagagc aaatggcgaa attcgaccaa 2687881 accatttgtc tggagcaagc ggttgaatct gttgagaaac aagcggacgg cgtgtttaag 2687941 cttgtaacaa atgaagaaac ccactactct aaaacggtca tcataactgc aggaaacggc 2688001 gcattcaaac cgagaaagct ggaacttgaa aatgccgagc agtatgaagg caaaaacctc 2688061 cattacttcg ttgatgatct gcaaaaattc gccggcagac gcgttgcgat ccttggcggt 2688121 ggagattccg cggttgactg ggcgcttatg cttgagccaa tcgcaaaaga agtatcgatc 2688181 attcaccgcc gcgacaagtt ccgagcgcac gagcacagtg tggaaaacct tcatgcgtcg 2688241 aaggttaatg tcctgacacc attcgtccct gcggagctga tcggcgaaga caaaatcgaa 2688301 cagctagtgc ttgaagaagt gaaaggcgac cgcaaagaga ttttagaaat tgatgactta 2688361 atcgtcaact acggtttcgt ttcatctctt ggaccgatca aaaactgggg cctggacatc 2688421 gagaaaaatt ccattgtcgt gaaatcaaca atggaaacaa atatcgaagg cttctttgca 2688481 gcaggtgaca tttgtacata cgaaggaaaa gtcaacctga ttgccagcgg cttcggcgag 2688541 gcaccgacag cagtgaacaa cgccaaggct tacatggacc cgaaagcccg cgtacagcct 2688601 cttcactcaa caagtctttt tgaaaataaa taataaaaaa aggagcttgt gtctgcgaca 2688661 cagctccttt tttatttgaa gatatttata taattcaatg cagttcctac aaccagcgca 2688721 atcacaaggg ctgcgactac ccagatcatt gccataataa tgcggtcctg aatcttttgg 2688781 gacttcggtg ttttttcttc gttttgggcc atcttattcg ctcctttccc atgtccatgc 2688841 cataaagaaa gcctggtgct gaacgaccaa gctttgctga acgtatatca ttcgcgtttt 2688901 gatccgctct ctaagaccat tcgttaaaac tatgatacct aaactcaccc tgcatgacaa 2688961 gcttcggcac ttgcaccaca cctgccagca aatcataatg tttgacatcc taaataaaac 2689021 agagtacatt atataaggcg aacatttcat atattatact tttaaatatt cgtttttagg 2689081 agtgaaaacc atggaaaacg tatttgatta cgaagatatt cagctaattc ctgcaaaatg 2689141 cattgtgaat agccgttcag aatgtgatac atccgtacgt ttaggcggac atacatttaa 2689201 attgcccgtc gtccctgcca atatgcagac gattatagat gaaaaactag cgatttcatt 2689261 agccgaaaat ggctactttt atgtgatgca ccgatttgag cctgagacac gaattgattt 2689321 tattaaagat atgaacgcac gcgggttatt ctcttctatc agcgtgggcg tcaaagatga 2689381 ggagtatgaa tttgtccgcc agctggcaga agaaaatctg actcctgaat acgtgacaat 2689441 tgacattgct cacgggcact caaatgctgt cattgaaatg atccagcacc ttaaaaaaca 2689501 tttgccggac agctttgtta ttgctggcaa tgtcggaacg ccggaagcgg tcagagagct 2689561 tgaaaatgcg ggagcggatg ccactaaagt cggcatcgga ccgggaaaag tatgtattac 2689621 gaaaatcaaa acaggcttcg gcacaggcgg ctggcaatta gcagcgctgc gctggtgtgc 2689681 caaggctgcc agcaaaccga ttatcgcgga tggcggcatc cgcacccatg gcgacatcgc 2689741 aaaatcaatc cgattcggcg caacgatggt catgatcggt tcactatttg ccggacacga 2689801 agaatcgcca ggccaaacga tcgaaaaaga cggaaagctt tacaaggagt acttcggctc 2689861 agcctctgaa ttccaaaaag gcgaaaagaa aaatgtcgaa ggcaaaaaaa tgcacgtggc 2689921 gcataaaggc tcaatcaagg atacactgat tgaaatggag caggatcttc aatcttctat 2689981 ttcttatgca ggcggaacaa agcttaacgc catccgcaat gtggattatg tgattgtgaa 2690041 gaattccatt tttaatgggg ataaatatta atcataaaaa aacgccaagt cagcggttct 2690101 ccgcttgagt tggcgttttc tgctacttct tcagcaaagt aagcttatat ttgctttttg 2690161 agtttatctt ccatcagttc tgccatttgt tttgcatttg gattttcttc attttgcaac 2690221 tgttcaatga cgttcatata atccgtttca tttcggttct ggcttaattt atatgccgct 2690281 tgaatgtctt ccaccttaat cttaaatcca acaatacctt tcaattcact ttctaagagt 2690341 tttggagaaa gcttatccca taacacagga ttgtcacgat gtttttcgta tttctccaac 2690401 atgattgtta attcttctgc taattcatct ttctctaaca tacttgcttt tccatacatg 2690461 tggacagcct gataattcca cgtcggaaca ttttcgcgcg aataccagga agaagaaata 2690521 taagcgtgcg gtccctgaaa catcacaagc acatcttcac aggcttcaaa cgttctccac 2690581 tgaggatttc cataagcgaa atgccccgta atatagtaat gatcgtcttt tttattgaat 2690641 cctaacggca aatgtgtggc aattggtttt ccttgttctg ttgtgacaac cgtaccaaag 2690701 gagttttctt gtacaaaatt ccaaatttct tcagcatttg tgactttaaa atattttgga 2690761 atatacatca tcatccaccc ttcgaaaaat attatatgag tgttttagcc atgattaaat 2690821 ccgtttgttc ttcatcaccc atataaaatg agtgggcgcc ggtctgaaca aaccccattt 2690881 tcttataaaa ggcaatggca ttttcatttt tttcccacac acctagccaa atgttctttt 2690941 tattacgttc cagcgcaatt tctatcgctt tattcagcag atgtttgcca agcccatgtt 2691001 tttgaaagct gttctttata taaattctct cgatttcaag tgattcagca cccatttctt 2691061 cagactgagc atcatcgata ttgaccttta catatccagc gatttcatga tcaaagtaaa 2691121 taaaaaagaa ttgcgaagac atattagata actctttttc cagctgctca gtgttaaatg 2691181 cgctttctaa ataggctttc atattttcag gtgagttctg ttctttaaaa gtgtcattga 2691241 atgtttcaat actcaattgt tgaagtgttt gtaaatcttc ccggctgcat tttttcattt 2691301 ttacactcat tgttcggatt cagccccttt atttaaaatt caattgtctt gtgtcccttt 2691361 tatatattta aacacggaac acatactgac cttgttacca ttccaaaaat cttcttcatc 2691421 accaactccc tatcgtgatt ttgttgtaaa tgcaataaaa tatactccgc attaaatata 2691481 tcgtaacttt gctgtattta caacaaaaat caaacaacaa agcagcgttt ctcttgccga 2691541 agttcccgga actctctgca tcatttcccc ataataaaaa cgcctccctt aacgatgatt 2691601 tatcgctaag aaaagcgtca gtaatagttg ctatccgttt ttagtgctta gcactcttca 2691661 ggcttgcctg cattcgttgc tgttctgaac gaagaaccgc agccgcatga agcgatggcg 2691721 tttggattgt cgatggtgaa gccgccgccg agcatggatt gtttataatc aatcacggtg 2691781 ccgttcatga tgtcaaggct ttctttgtca actagaacag tgatgccgtg ctgatcaaac 2691841 acactgtctg attcactctt ttcatgctca aagcccatgc cgtaagaaag tccgctgcag 2691901 ccgccgcctt tgacgcctac acgcagaaac gcgttttctt cttcatgctc tttcatcata 2691961 tcttttatat gcaaagctgc tgcttctgta attgttaccg ggttgctcat cattatgaac 2692021 ctccttttaa aaaccggttg ctgtctttta ttataaacat gatcgttcca attctcaaac 2692081 aaggtgtttt acaagaaata gacaccctca caaacggttt cagccggccc tgtcatcatt 2692141 acatggccgt tatctttcca gtttatcacc aaatccccgc ctgctaaatg caccgtgatg 2692201 tcttgatttc gctttgatac gccgtttaat acagatgcga ctgccgctgc acatgctcct 2692261 gtcccgcatg cctgagtaat ccctgatccc cgttcccaga cgcggaaatg caattcttgt 2692321 tcattcacgg tttcaacgaa ttccacattg atgccttccg gaaatctcgg atctttctca 2692381 atcaccggcc ccagtgtcgt taagggtgcc tgttcaatgt ctgcgatcgg aaaaacgata 2692441 tgcggatttc ccattgaaac ggcagtgcct gttagttcta cttcaccaaa tgccatcgtt 2692501 tcattgattg tgtgctcttc cccgccgtca agcataggaa gctcggattt tgtcaagcgc 2692561 ggttcgccca tatcgacagt gaccacattc acttttccgt tttcgacttg aacctccgct 2692621 ttcacaagcc cggagagagt ttcaatcaga aaagatgttt cctcaaccag cttatgctca 2692681 tatgcgtatt ttgcgacgca gcgcaggccg ttgccgcagt ttttcccttc agacccgtca 2692741 ttattaaaaa tccgcatttt aacaggcgct tggtctgatg ggcatatcag gatcattccg 2692801 tcggatccga tccctgtata aacagaagaa acctgaattg caatctctga cagtttttct 2692861 tctggaagct gttcttcaaa ttgattcaca taaatataac tgtttcccag gccgtgcatt 2692921 ttggtaaatc gaaatgagtt cataggtgcc tccaactttt tttctttttc ttagtataaa 2692981 agctattata agcggacaca atacaattat cccccgtttt tcatacataa aagctccttg 2693041 cactgacgca aggagctttt atcgtttata taaacatgcc ggcaatggct gcgctgagca 2693101 gattggctaa tgttcctgca agaacagcct tcaggccgag acgtgcgata tctgaacggc 2693161 ggctgggcgc taaaccgcca agcgtaccaa gcataatcgc aattgatgaa aaattggcga 2693221 atccgcataa cgcgaaactg ataatggtag cagttttctt agaaaactcg ccgatgtgcg 2693281 aaccgaagtt agaataagcg acaaactcat tcagcaccaa tttctggccg atatagcttc 2693341 ccgcctgcaa tgcttcatgc caaggcacgc caatcaaaaa ggcgatagga gaaaacacat 2693401 agccgagaat ggattctaat gttacgcctt ttaaaccgaa caagccgaaa gccccgccga 2693461 gaataccgtt tactacagcg attaacgcaa caaacgcaag cagcatcgcc ccaacattta 2693521 acgcaatttg cagtcctgtt gacgctccct ttgcagctgc gtcaatgaca ttggctgcgc 2693581 cttcgccttc atccattttg aaatcgcttt ttacggtttg cgttttttcc gtttcgggta 2693641 taatcaattt accaaagact agtccagctg gagcagccat aaagctggcc gccagcaagt 2693701 actcaatcgg aataccgaga agcgcgtacc caaacaaggt agatcccgca actgccgata 2693761 gaccgctcgt cataatcgta aacaactcag agcgcgtcag cccggcaatc aggggtttga 2693821 tcactaacgg agattctgat tgtcctacaa aaatattggc agcagccgcc agagattccg 2693881 ttttgcttgt tccaaggagc ttcgacaatc cgccgccaat gacacggaaa acgagctgca 2693941 tgattttcaa atgatataaa actgcaatca gtgctgagaa gaaaatgata acgggcagta 2694001 cacttaatgc aaatgccgga ctgtctccga cctttagaag cggtccaaaa ataaaactga 2694061 tgccttcatt cgcatagtca atcagaagct gtacacggct tgaaaaccat aaaaaaacag 2694121 cgcgtcccgc ttcccatttc aacacgatgt atccaaacgc cacctgtgtg cataaaccaa 2694181 cgatgacggt tcttatctta atattgcttt tcttttctga aaataaaaac gcgatagcaa 2694241 tgatcgcaac tgcgcccagc agcccccaca gaacattcat gaatactcgt acacctctta 2694301 aattttattt aaaaaaatat cttttatacg ataacaataa tattttttga tgtctacaca 2694361 tttttttagt tcttttgtac ggcaaaataa aaaagggcct gtccaggccc ttttctttaa 2694421 aacattggat tttcttcaat aaaggtatat atattctcaa caagctcagc aggcgtttca 2694481 cccatgacga cttctccgtt taccagagcg aaaagcgatt ccatacatgt cccgcagtag 2694541 cttaagcagc catattcaag gacatcaagg ttgggatcct tctccaaaat cgcccgggct 2694601 tcctgagagc cgtgagccag attgctgaca caaaattcaa tcattggatt catgcggttt 2694661 cacctcacat atgtccatta tcgcgaattt ttcactattc gtcaaagaca acggatgatt 2694721 caaaatttat tatcgtaaca tattatttct caaataacgt tttactaatt tgtgttttca 2694781 ggctaaattg taggttattt tgaaactatt attgtgattt tagatcaaat tcgatataat 2694841 tctagatgtt attttacata gttcgtattt tcttcaatgt atctatcata ctcttcggat 2694901 taaaggggaa ttcaaatgaa aaaattggtc ttgatcggcg gaggttacgg gaacatgcgc 2694961 gttcttcatc gcttattgcc aaaccagctg cctgatgatg tttcaatcac gttaattgac 2695021 agaaatcctt atcactgctt gaaaacagaa tattatgccc ttgccgcagg cacaatttct 2695081 gaccatcata tcagagtgtc attcccagag caccctcgcc tggatgtcca atacggtgat 2695141 atcacatcaa ttgatattgt acaaaaacaa gtgctgttcc aagatcgtga accgatttct 2695201 tacgatgacg ccataatcgg gctcggctgt gaggataaat atcacaacgt gccgggagcg 2695261 cctgaattca cctacagtat tcaaaccatc gatcagtccc gcgaaaccta ccaaaagctg 2695321 aataatctga gcgctaatgc caccgtcgcc attgtcggag cgggcttaag cggcgttgag 2695381 cttgcaagtg aattgagaga aagccgtgat gacctgaaca ttattttgtt cgaccgcggt 2695441 aatctcattt tatcaagctt tcccgagcgt ttaagcaaat atgtgcaaaa atggttcgaa 2695501 gagcacggtg tccgcattat taacagggca aatatcacaa aagtagaaga aggcgttgtg 2695561 tataaccacg atgatccgat ttctgcagac gccatcgtgt ggacagccgg catccagcca 2695621 aacaaagtcg tcagagactt agatgtggag aaggacgcac aagggcgtat tgtattaacg 2695681 cctcatcata atcttccagg tgatgaacat ctgtacgttg tcggcgattg cgccagtctt 2695741 cctcatgcac cgagcgccca gctggcagag gctcaagcag agcagattgt ccaaatcttg 2695801 caaaaacgct ggaatggaga agccctgcct gaatcaatgc cgcagtttaa gctgaaaggc 2695861 gtcctcggtt cactcggaaa aaaagccggc ttcgggcttg ttgctgaccg tccgctgatc 2695921 ggccgtgttc cgcgtatgct gaaatccggc ttgctgtgga tgtataaaca ccataacggt 2695981 taatgataga gaagaaccgc tgatcaagtc agcggttttc tgtataccca tgcttctcca 2696041 tttcctcata aacgtctttt aattttggat tgccttcacc gacaattttg tcttctacaa 2696101 gcacaagcgg ataaaaatac tcgtcatttc tgattttttc cgcaagctct ttcgcatgtt 2696161 cattgtcagg cggctcatga atatcgatgt actgcatctc aaaaggctga tttggatatt 2696221 ttcttttcag cgcagcctca agccactcgt atgtatcctt ggctgtcggc atatttacac 2696281 agctcgcaca aacgttttct gccccgtaca cgcttagcat gactggtttc atcacttgta 2696341 gacgccccct tctcctatgt aagtcctttc ttttaagtat acagagccta agggcgtttt 2696401 tatagaaaaa aaccgttttt gtgttgaagt ctgaatgtgc tataataggg aaagcaactt 2696461 tgcaaaccaa acaatagatt tttattgtta cactgaatat aatggtttta tgacgacgaa 2696521 aggagcgaat gtcatgactg aagttgaaat gaaagaacag gtgcaggaag tactggacaa 2696581 acttcgtccg tttttacttc gtgacggcgg tgactgtgag cttgtagacg tagatgaagg 2696641 tatcgttaag cttcgtcttc taggcgcatg cggcagctgc ccaagttcaa caattacgtt 2696701 gaaagccgga attgagcgcg ctcttcttga agaagtgccg ggtgtcgttg aagtagaaca 2696761 agtcttttaa taaagcagcc aggctgatat ttgatcagcc tggctttttt attagagatg 2696821 ttgatcaaac catgagctga tataattcag gcgcttgatc cgctgtcttg ggtgtccggt 2696881 gcgtgataaa ttgtgcgatg cattcggaaa acggacaagc ttggtttcct tgcccatttt 2696941 tttcagagcg ataaacagct gctccgcctg ctcgatcggg catcggtcat cccgctcgcc 2697001 atgcagtatc aaaagcggtg tctccacgtt tgctgcgtat tttaaaggag accggtccca 2697061 gagcttttct gtgtcctcaa acatgtcatg ctcaagctgc cagtctgtaa agaaatagcc 2697121 gatatcactg acgccgtgaa agctgatcca atttgatatc gagcgctggg taacggcagc 2697181 tttaaagcgg ttcgtctgcc cgacgatcca gttggtcata aaacctccgt agcttccgcc 2697241 cgtgacaccg agccgcttag gatcaatatg cggatctcgt ttgatagcct catccacagc 2697301 ctgcatcaca tcgtcataat cctttccccc ataatctcct ctgaccgcat tcacaaattc 2697361 ctgcccgtag ccgtggcttc ctctcggatt gatataaacg accgcgtatc ctttcgccgc 2697421 cagcacctga aactcatgaa aatatgtatg tccgtacatc atatgcggac cgccgtgtat 2697481 gttaagaata agtggatatg ttgtctcacc ttccatttgt gcaggcctca tcagccagcc 2697541 gttcaccatc acgccgtctt ctgtagcata ttgaatctct tcaggtattg atatcgtatg 2697601 ctccctgaca aacttgtcat tcgcgccagt cagctgtttc tcttcctgtc caagcgggat 2697661 actgtaaagc tcactcggtc tgtccggctt tgtcacactg gcaataaagt gctgttcatc 2697721 aggtgaaaga gaaaagctat tgatgtactc tttttccaga cgaatcggat acacaaggcc 2697781 ttcaatcgaa atataataga tgcccgtact gccttgatct gtgccgatga cataaaaccc 2697841 ttggctgtcc tttgtccaaa tcgggcgctg ttcagcacca ccgatcaatg aatctccaat 2697901 cagcgcatcc gctaaatgaa cgtccagcat ctcagtaaga catgtgaggc ggccttgttc 2697961 gatatcatag agccacgcct ttgagagcgt agcattctta tattcctttt catttccaag 2698021 caaagcaaga taccttccgt ctggtgaaaa tgagcttgat ccgaatgagc cgcgatgagg 2698081 tgtaacctgc ttaagatctc cagactccag tgacattatg taaacatcat gcggcttgct 2698141 ggcatcatct gtttcagtta aattagctga gaaaacaagc catttgccgt caggagaaaa 2698201 agcaggatca ccatgatcag ctttgtgact tgtcagctct ttcatctcac ccgactttac 2698261 gctgacaagc acaagctggg catacgcacc tctcgtcagc cctttgccgt cccgtttgta 2698321 ggagaggcct tgcacttcaa caggttcata gctgtcctgc tctgtttttt ctcggtcatc 2698381 aatgctttcc ccctctccca aactgacagt gaccagaatc gattcaccgt ccggggacca 2698441 tagcggcttt gacacgccat atgggatatc agtcagtttt cttgcttctc cgccttcagt 2698501 gctcatgata taaagctgtg ccgcatcgcc ttctcgatca gaaataaagg caagcgtgcg 2698561 cccgtccgga gaccatcttg ggtcggtgct tcgcttttct ccatgtgtcc aaggaacaga 2698621 tcctcccgtt ttcgtttcat agatccatat atttgatgta tacgaatctt tctcttgatt 2698681 tacttgtgat tttacatatg cggcacgggt accgtctggg gcgtattgag gatcggtcac 2698741 agagacaatc gctgtgatgt cgtctgcggt tatcagcttt ttcatattca tctcctcctt 2698801 tttacatgta tttcgttttt ctaaataaaa actcctttat ctccagcaaa aaaaagcgcc 2698861 ctccgctgac gctgaggaac gcttggcatg atctatacac tttttacttg atataaagga 2698921 tttcgctcta ttatacttcc ctctttcgga acggtcaaag cgtctacttc acaatgaggg 2698981 aaatgaagcg cgagctgttc ttttagctct tctccctttc ctttttcggt catgacgaga 2699041 atcgttgggc ctgctccgct gagagccgtt ccatatgcgc ccttcatctc ggcgacgtgc 2699101 tctacttttg acagctcagg cacaagcatc gcccggtacg gctgatggaa catatccttc 2699161 ttcatgattt tcccgacaag cggccaatcc ttggacatga tcgcagcaat gaggatattg 2699221 ctgacagcac ttgcttttac ggcatcggca tatggaaact ccttcggaag cacgtctctc 2699281 gcgtctcttg tcagcacttc ataaaaagga atgacaacga ctacgtcaat gtcagcattc 2699341 gggacgcgga tcatttgggt ctcgtcatcc tcatgcaggc cgatcacaag tccgccgacg 2699401 agagaagcgc cagcattgtc cgggtgtcct tcttctagac tcgctaaatg cagcttgtcc 2699461 gcttcagaca gctttaagcc gcataattca tcagccagtt caatggccgc tacaatcgct 2699521 gcggcgctgc tgccaaggcc gcgtgcaagc gggatgtcgc tccacacctt cacatggaca 2699581 ggaggcattt cttttccgta caaatctgcg gtccgtttag ccacttggta gatcaggtta 2699641 tctgtacccg ccggaattcc ggcgactgtt tctgtttcag cctcaaaaga ccatttgtcg 2699701 ctttcaaaga cggtcagctt caaatatctg ctgagcgcca ttccgactga atcaaagccg 2699761 gggcctaggt tagctgtgct tccgggaaca gtgacagaga acagcatgtc ggcttcgttc 2699821 atacacgggc cgctcctttt acatattcaa ggatgctgtc ttcatcagtc ggcaatgtga 2699881 caggcttgat ttctgaaatg tcgaccgctg tgttcggatc tttcagtccg tttcctgtta 2699941 acacagctac gaccttgctg cctttcggaa tttctccgga tttcacctgt ttcagcactc 2700001 ctgcgataga cgcgcaagaa cctggttctg caaacacgcc ttctacacgg gcgatcagct 2700061 gatatgcgtg aaggatttca tcatcagtga cttcgtcaat tttcccattg gattcctcgg 2700121 ctgcctttac agctttgtcc cagcttgccg ggtttccgat acgaatggct gtcgctattg 2700181 tttccggatt ttcaatcact tcattgcgca cgattgccgc cgcaccctca gcttcaaagc 2700241 cgcgcatttt cggaaggcct gtgccgtttt tctcatgata ttccttgaag cccttccagt 2700301 acgcagtgat gtttccagca tttccgaccg ggatcgctaa aacatcaggc gcttccccca 2700361 gctgttcgca cacttcgaag gcagcagttt tttggccttc aatgcggtaa gggttgactg 2700421 agttgacaag ggcaatcggt gatttctcac agatggaacg gacaatttta agcgcatcgt 2700481 caaagtttcc gtcaattgcg ataatctcgg ctccgtacat gacagcttga gcgagttttc 2700541 caaatgcaat ttttccgttc gggatgatga caatgcattt catgttagca cgggctgcat 2700601 atgctgccgc agcagcggaa gtgttacctg ttgacgcgca cataatcgtg tcattgcctt 2700661 cttcttttgc ctttgccaca gccataacca ttccgcgatc tttaaatgat cccgtaggat 2700721 tgacgccttc cgttttgaca tgaagctcaa ttccgagctg ctcagacagc ttcggcaggt 2700781 gaataagagg tgtgtttcct tcatgtaaag ttagcgccgg tgtttgatct gttacaggta 2700841 aaaattcttt atattgatgg ataagtcctt tccacattag ctccaaccgt tcccttctac 2700901 acgatatgtg cttttgactt cttgaacgac ttccaaatca tttaggtttt gcaggatatc 2700961 actgaaatca gcttctgatg tatgatgtgt gacaattacg atttcagcta actcatcatg 2701021 gcctttaatt ggcagctgaa ggattttttc aaagctcacg ccccgctctg agaacacaga 2701081 tgtaattttc gagaatgaac caacctcatc ttttacatga attcttaaaa actgctgtgc 2701141 ataaatgtca gacggcgatt tcatgttttt ctcatattgc ggtccgacaa agctgttgcc 2701201 ggttacacct aggcgcatat ttttcatgac agcgacgagg tcagaaacaa cggatgtcgc 2701261 tgtcggcatg cttccggctc ccggcccgta gaacatcgtc tcaccgacag cctcgccgta 2701321 tacataaaca gcgttaaact cattatgaac agcagaaagc ggatgatggt caggaagcag 2701381 tgtcggctgt acgctgacct cgattttgct gccgtcacgc tgagcaatcc cgatcagctt 2701441 cattgtatag ccgaggcgtt tgctgaagct gatgtcctcg tctgtaattt gggagatccc 2701501 ctttactttg acgtcttcca gatccacgtt catcgagaag ccgaggcgcg ccaatatcgc 2701561 cattttccgt gcggcgtcaa gcccttccac gtcagaagtc ggatcagctt cggcaaaacc 2701621 gagatcctgc gcttccttga gcacttcctc gtatgggctt ttctctttga tcattttggt 2701681 taagataaag tttgttgtgc cgttcacaat tcccatcatt tttgtaattc gatctgatga 2701741 gaggccttcc tctaacgtgc gcagaatcgg aatcccgccg gcaacactgg cttcaaagta 2701801 gatatcgcat ccattttcct tcgcttcggc aagcagctcg gagccgtaca cagccattaa 2701861 gtccttgttt gctgtgacaa catgcttttt cgatctcagc gcgtcgacca aatattgttt 2701921 tgtctgttca acgccgccga tcacctcgat gacgacatca acatctggat catcaatgac 2701981 atcatacact tctgtcgtga gcacttcctt cggcaaatct acttctctct ttttctctaa 2702041 atcttttaca agcacttttt ttatcgtaac cggacagccg acctgatgca taagcttatc 2702101 ctgatggtct tgaataattt taacgacacc gcttccgacg gtacctaaac ctaaaagccc 2702161 tacacgaatc gctttcaaaa aaactccacc tttcttttga ttgtcctctt ggaaaagaca 2702221 attgttaact caacacagac atataagtta caaacattat ataagcccgc tcctgttttg 2702281 acaagacatc attaggctga attttgcgaa tgtaaacgct taacgcattg atatgacaag 2702341 attctttatt ttctaattat ttttgtcaga ttttctcctc accttgagct gcctttgccg 2702401 agccagctga cgcgtggaac aaacagcttc tgcgcccgca tattcatgaa ttcctgcgct 2702461 gtattgagaa attgttcata acgcccacag tcattaagaa tgaagtcaag ctgttcttca 2702521 aaataatgct tttctgattc tgatgacatg taatagcttt ctacgatttc aaaataatga 2702581 agcgggaaaa gcagacggct gtataaaagg cgtttcgaaa atgaagacag cggtgtgact 2702641 tgctcgtatt cctgtaaaaa gagaaagccc tgctgattaa aatcttgtct gtgatgcaaa 2702701 aacgtatgcc tcatatattc agccaaatca cgggaagcgt ggtcaaacac ccaatccgcc 2702761 ggaatcctga tcaatgattc cggtgaccat gtatgccttt ccatccgctg atggcatatc 2702821 gttcctgaat cagcggcttg gggcttgtca tccagctcag tgtccactaa atattgtatc 2702881 gcgttttctg acagtcctaa ataatatgga aatgattcga tcattttttt atcgaatggc 2702941 tcatgcggag gggtctgaac ctttctctgc caaaatgctt ccagctgatc aattcgtttt 2703001 ccccacagat ccttccactg gccgattctt ccggccgcct tcacctcata tggatatcct 2703061 cggccttttc ggtgaaattc cgcaagctcc gctccaatgg agaacgccct gtttgaataa 2703121 gggggggccg ccttcagcag agcgtacgtt tttccctcat gttcaaatgt cagttcacct 2703181 tcttttgtaa agataaaaac cgaaacgtat gggtcacttt gttcttgtaa atactgactc 2703241 atgtaataaa gctccgccag ctctgtttct gagaattggg aaacggggac aatcagaaag 2703301 tatgaattag gcgtctgaaa gcattgatat gtgtgctggt acatggaaag ctgcctgatg 2703361 tgaatgccgt atttttcttt tattgtacct ttcaccatga tcacctgcct gttgaattag 2703421 ggctcatcac atcgtagtca tacacagccg gaattatgaa tacatatttt aatccgaaga 2703481 aggcgcaaga aaaagtcgta aacttctcaa gcattttgta taaactagta aaaaagattg 2703541 ggtgaagctg atgtcagaaa acgaacaatt cagtcagatg gaagctaaag caagagcacg 2703601 gatgaaggag cgcggcgttg aggtatcaga cattgccgag cttgtctttt ttctgcagaa 2703661 aaaatatcat ccggatttaa ccattgatga atgcacgctg aacgtcaatc gtgttctcgc 2703721 aaaacgcgag gtgcaaaacg cgattttaac gggcattgaa ttggatgttc ttgctgagca 2703781 gaaaaaattg tctgaaccgc tgcaaacgat gctggaaata gatgaaagcc tatatggagt 2703841 agatgaagtt ctggcatttt ccattgtgaa catttacgga tcgatcgggt ttacgaacta 2703901 cggttacatc gacaaagaaa aacccggaat ccttaaacga ttgaatgata aatcaaccgg 2703961 tgaatgccat acctttttag atgacatcgt cggagcgatt tccgccgcgg cttcaagcag 2704021 acttgctcac cgcgcgcggc atacagaata agggcaccct tttagggcgc ccttttttca 2704081 aatgtatgga atccattcag tcagagagtc aatggcgtga gtcggttttt ccatatcgtc 2704141 tgtcatatgt tctcttttcg ttacgcctgt gtgaacgagc agcgtatcca tacccgcgtt 2704201 aatgccggcc ataatatcag tggcgtagtt gtcgccgacc atgagtgttt cagacacatc 2704261 tgtgccgaga acgcgcatcg cctgctccat aataattgat tccggcttgc cgataaatac 2704321 aggctgtaca cctgtagata cggttaacac cgatgtcagt gagccgtttc ccggcaggag 2704381 ccctctttca gtcggaatcg caatatctcc gttagtggaa ataaagcggg cgccatttct 2704441 gattgccagg cagccaacag caaatttttc gtatgtaatg gaacggtcga tgccaacaac 2704501 gacaaaatcc gcgttttctc cgccaaatgt caggccgttt tcttcaatcg cctggcggat 2704561 tccttcctcc ccaatcacat acacagacgc gtcttttttc tgctgtgcaa tgtgctgggc 2704621 agttgccatg ctggtcgtga agacctgctc ttctgttgcc ggaatatcaa aagacacgag 2704681 cttgtccgct acctgcttcg gtgtgcgcga agagttgttt gtcacgaaaa gataaggaac 2704741 gccgcgatct ttcagcgttc tgacaaattc acacgcctcc tcgatttttt ccgtgccatt 2704801 gtacatcgtt ccgtctaaat caattaaata ccctttatat gttttcatat ccaacactcc 2704861 tgtggctttc cagttgttat ttaaacgcgg aaacaggtcc tagctctgtt tccaaatagc 2704921 ttctgatccg tttcgggaag tcctgaagag ctgtttgatg cgccttgatc agcctgtaaa 2704981 gctcgccgct gtcagcgagc agatactgtt gaaccaacgt tttgcggtag gcgatcaatt 2705041 ttttgagctc atcaccctct ttttccgtga caactttctc atcaacaagt atatccataa 2705101 tgtcgtcata gctgcccggg tcccgcataa taaagccgtc aatcatgtca ttgcctgtat 2705161 ccaaaatgca ttcgattaac agatggccta tacgctgaag tgccaattcc ccgatttcag 2705221 actgccagtc tgtttgtgag tcaaatagcg ccagctggtg ctcgaagaac cctagtgttt 2705281 tttcgatttt gcttctgtca acaaaataca tgacagcatc ccctttgtgt atatttattt 2705341 tctgatccgt ttcaagacaa aatacgcaca gccgaaattg cagtattcgt aaatatattc 2705401 atctaatgtg ctgattttcg tttcgaaggt tgccttttga ttctggtcgt caaagaagcc 2705461 cttgagcctt aactgaccgt atccccagtc tcccacaata taatcgtatt tatttaatat 2705521 atcggagtag cgggctttaa aagcctcttc gttgaagccg tctttgaaat tgtgcaccaa 2705581 ttcaaattcg gcattttgaa taagaatcat gatctcacct cttttttcac tcattcctat 2705641 cataattcat tgccccgtcc ccatcaattg ctaaagaata aatcatgcga tttggctacc 2705701 ctacacatga ggagggattg ataaatgaaa cgaaccgctg tcagcctctg cctgctgacc 2705761 ggactattat ccgggtgcgg aggcgcagga ttggataatg cccaaaatgt ccggaatcag 2705821 acgcagaatc aaaccaaacc cattcatgtg tcggaccgca acgaggcttt taacaggcat 2705881 aatgagaacg aacaatttgg ctatgtccgc tatcaaaaag aacaatttga cggagaacag 2705941 cagaaaacgc cggtgatgaa ccgggaagaa accgctcaca tgatatcaag tttaacggtt 2706001 cagctccccc atattcaaga tgctgcgaca ttggtgactg accgagaagc gcttgtcgta 2706061 tacaaaaccg attctaaaaa ccgggagctg accgccgatc aggtgaaaaa aacagcggct 2706121 tctgtgatac cgcgatacta tcacgtgtat atttccgata atccaaacca tatgcaatcc 2706181 gtcgaaaatt acagcaatct cggctctggt tcaagggata ttagagagat catgtcgggg 2706241 acgattcaag aaatgaaaac ctccccgcaa ggaagccctg tctcagagaa tgaaaatgcc 2706301 aatggagaaa cgcgtcagga catgaaaatc gataggaatg acaaaaacgc cagatgatct 2706361 ggcgttttgg cattatgctt gtgcttgacg ctttttagat gcttcgttta cttgttcatc 2706421 cgcatggtaa gaggaacgga caagcggacc ggcttcacaa tggctgaagc ctttttgcat 2706481 cgcgatttct tttaattctg caaattcatc aggatggtag tatttttgga ctttcaagtg 2706541 tttcttcgtc ggctgcagat attggccgat tgccataata tccacgttgt tcgccaagag 2706601 gtcgtccatt acttcaataa tctcttcttt tgtttcgccg agtccgatca tgatacttga 2706661 ttttgtcgga atgtcaggct gcatttcctt cgcacggcgc aaaaattcca atgaacggtc 2706721 gtacgtcgca cgcgcgcgga ctcttggcgt caggcggcga accgtttcga tattgtgatt 2706781 caggatgtct gggcgtgtat ccatcaaggt ttttaggtta tcgtagtttc cgcccatatc 2706841 agacggcagc acctcaattg ttgtgaacgg gctttttctg cggatcgcac ggacagtttc 2706901 cgcgaaaatg cctgccccgc catctttctg atcgtcacgc gcaacagccg taatgaccgc 2706961 gtgtttcaaa ttcataagcg cgactgaatc cgctacgcgt tccggctctt gcagatcaag 2707021 ctcagttgga aggcctgttt tgacagcaca gaaacggcat gctcttgtac aaacagaacc 2707081 taaaatcata aatgtcgctg tacgtctgac cgcccagcat tcatgaatat tcggacactt 2707141 tgcttcttcg catacggtat gcaggttgtt ttcccgcatg agttttttga gccctgtata 2707201 gttttcattt gtatttaatt taattttaag ccattcgggc tttctgaggt gttcgtcttt 2707261 ctttgccaat tcccatcatc tccaatatcc aatatactca atttctgaca cgaaacattc 2707321 tgaaaacgag aaaggtgcag gttttagttc tgcaacaaaa ataatgtttt tctaactaaa 2707381 gaaagtcttt tctttagaca ctttaacata ggaaaaattt ctcgacaagg gaagatgatt 2707441 actgacattt ttaagccggg ttgccgcaaa ctatgtgtat tcaatatgaa aggagattat 2707501 tttgtgaaag ttttgttatc cgctcttctt ctccttttgt ttgcatttga gccttctgcg 2707561 tctggaaaaa aactttcaga tccagtgctg tcgaaacgga tggaattata tcataaaatc 2707621 gaagctgtga cgcagatccc ttggtatgcg ctcgccgctg ttgatcaata cgaagaaaac 2707681 gtgcggagca accggaaaga tctgcctgaa aaggcgggaa tcatcagcat ctatataccc 2707741 gatgatatct ggagcgggcc tgaaaacccg aatccgaaag acgatgcgcc gttaagcatt 2707801 aaagtgtttg acggaatcgg aatggatggc gatggagacg ggaaagccga ggtcagcaac 2707861 gatgaagata tcttgtatac gttcagccaa tacttactgt cgtatggcac agatgaagac 2707921 aacatccgga tcgggctttg gaattattac cggcgtgatc agacagtggg gattatatct 2707981 gaattcatga agctgtttaa agcctacggc catattgatc tgggcgagca tgcattcccg 2708041 cttccgatca gaaccgatta cagctaccga agcacgtggg gagatgcccg cggcttcggt 2708101 ggaaggcgga ttcatgaagg tacggatatc tttgcccatt acggccttcc tgtcaaatcc 2708161 acatgttacg gcgtagttga aatgaagggc tggaaccgct tcggaggatg gagaatcggc 2708221 atcagggaca ttaacaatac gtatcattat tttgcccatc tcaatgggtt tgccaaaggg 2708281 attaaaacag gacaaatcgt tgagcctggc caagtgatcg gatcagtcgg cagctccgga 2708341 tacggcccgc cgggaaccgc cgggaagttc ccgccgcatc tgcactatgg catgtacaaa 2708401 gataacggaa gaaccgaatg gtcatttgat ccatacccgc atttgagggc gtgggagcga 2708461 tatgaatacc aaaaaaagaa gtaacaaaaa gccgcctctt caacaggcgg cttatttgct 2708521 gcttttttct ttttttgaat cggcaccgtt ttctttgctg ctcggaagct ggacagaagg 2708581 cgtgacaccc gagccgccgc ttccattata aaactgcggc acttcgccct gcactgcttt 2708641 aatcgataca ggaacattat ttgtgacgac agcggttttg ctggcaaatg gaatgatgac 2708701 cttcacttta atttcgacaa agatgctgat atcaataagt gcgttattta tgccatacgg 2708761 cttgattttg gttttgacat ctgtaaaagc gtcaccgatt aaattgaacc ggaccgggat 2708821 tttcggcccg aggtttccaa gaaggctgtt gccggttacc tgtcccagcg gaatgttgat 2708881 cataatgttt tcactggcgc cgctgtgtcc ggtatgggtt tccatctctt tcaaatgagc 2708941 ctgaagctgc tttgtcactt ttgttttcac actgtttaca acctgtgtat taaaatcgat 2709001 tgtcgttaag tttccgtttt catcagaatt catttgaaac atatctttca tattttcact 2709061 gtcagacata tagtcctcaa tcgaatcctg gatcacctct gtcgctatac gcttcgtttc 2709121 catctcgccg atgtccatta aaacaggttt gatcgagcca ttgatcatcc aaaggctgac 2709181 cgttgttgac aggataaaaa agacaacgga caggagcatc acgtaacgga aaggcaaagg 2709241 tcctctcttg cgaaaagggc cgcgatatct tggcaagaaa atcccccctt acatatcaca 2709301 atgtatgctt gtaagagggg acatagtaat agccggggcc aatttatttt atttcatcat 2709361 ttttaaaagc gcttctctgc cgctcatgcc gactttgatg ccaagatctt ccgcagcgta 2709421 cgtgacggat tctaaaggtg cgtctaacag ctggtcaatg gtgcggacac caactgcgcg 2709481 tcccgccacg atgccgcgct cctttaattt ttcattcagc agcgccacat caagcgcgcc 2709541 gcacataatg tatccgtgat cattggcgac ggccataaaa ttcgttttgg gaagctttac 2709601 tgtcacagct gtaaaaggct gtccttctat catgatcggt gtcaggttta ccacgtcaac 2709661 cactcccttc attcatcact ttatgatgaa gggcacagct tgttgtgggc tgactgcctt 2709721 attgtgcaag cttccaagca agcagatccc gcaaaaattc cggcataaaa tattcttttt 2709781 ctgcagcgtc gcgaatcaac ggaaacagtt tgccgagcgt aaacatatca agcaccgcaa 2709841 cggagtattg tttatgtttt tcaatatctt ccccgttcag tgtgatccga gtgacgtggg 2709901 tgatcccgtc atcgagccgt ttcgtttcta cctcaacgcc ggcatacacc attttcccca 2709961 tcacttctcc gcggaagccg agtcctttga tccggagctg ctccatttgt tcggaagcgg 2710021 catggacaat ggtttccttc agttcttctc ccgtcaggcg gacagccacc gggttgatcg 2710081 gatgcggaca gatgcggtgc agatccagct ttgtcacagg acctgctttt agcggaccga 2710141 gaatgacacc tgaattgacc atactgatgt ccgtctcgca ccattccttt aaggcgtatg 2710201 ccaaaagcaa aggcagctct gattcttcaa accacttcac ctcagcatct tgtgcaagct 2710261 ctgcaacggc atcggacagt ttctcctcgg cttcacgttc tttttcattg agaaacgctt 2710321 tagtttctgc ggattctcct gtccattccg ccatgttctg cacagaagcc gttttgctgt 2710381 tgatgcttcg ctgtacgctg tccaccgtga tttctacaca gccgacataa tgcccgtatt 2710441 tctcggcgct ggccagcagt accccattaa ccacttgtcc atcttcgagc aaatgatggg 2710501 tatgtgattc gaggattaca tcaatctcag gcaccgcttc agccactgct tgatcatcaa 2710561 gaatgcctaa atgtgacagc agaacgataa tatcagcctg ccctttcact tccagaatgg 2710621 tttcctttat gctttcaagg gcatccgtaa ctgtccatcc cagcttgtca tatacaggat 2710681 aatacggcac agttacacct aagaaagcaa tggacatacc gtttttcaat gatttgatat 2710741 ggtaaggcac cgcccaggac ggacggtttc catttttatc aaacaggtta gagacgatga 2710801 caggaaattc agcatgatca tataaggcag caagctcttc atgcggaagc gtaatccctt 2710861 cgttattgcc gatcgccgct ccatcaatgt gaaggcggtt taagagatcg acattcgctt 2710921 ttccgaatgt cgcctctgtc acgaattgaa aacgatcaag atgatcgcca atatcaaaaa 2710981 cgagcgtctc ttcgccgtct gactgatgct cttttctttt ctgctcgata taatctacaa 2711041 ttttcggcca gttttcaaaa tggctgtgca aatcatttgt atgatataag cggagcttct 2711101 ccttcataat atctctccct aatcgttcag ctgaaaatgc cttcataaat gagctggcag 2711161 ccgatcaaaa tcaatacgat ccgcatgatc ataacgatcg ttttcgtctg catttttctg 2711221 ttgatggcgg cgccaagctt tccgccgaac caagcgccgg gcacaagcgc gagggcgtac 2711281 agccaattga cgtgcccgga aatcatatgt gaaacagacc ctgtcataga agacaggaaa 2711341 ataataaaca tggacgttgc caccgcaacc ttcggcggaa acagaaataa cagcatcatc 2711401 gccggaacca tcagtgatcc gccgcctata ccgaaaagtc cgcctaaaaa accgacaaca 2711461 aaggcaatgg caataccgac agaggcctga tatgagtacg tataaggctc accggcatca 2711521 tcctgaaatg tccggataat tcctttgtgc gctttgttga ttggccgggc tttcgctttc 2711581 agcattaagg ataatgaaat cagaatcata aaaatgccaa accaaacgga aaacgagttt 2711641 gaattgaaca gctttgacac gtaagccccg atcatgctgc cgggacccga accgataaag 2711701 aaaatgagtc cgctcttata atcaactgtt ttatatttaa tataagccaa agttgaagaa 2711761 aggcccgtaa aaataatgac caaaagcgaa gttccaatcg caacctgcgg cgtcacatcc 2711821 tgaaacagct gcgtcactgt gcttaaaaac atcagagatg gcacaatgac aattccgccg 2711881 ccaagcccga tcagacttcc taccgtacct gcgattaatc ccagtacgac caaaatcaca 2711941 aacgacatca atcaaaacct cttttctaaa ataaatcgag ctgtctcgga gcaagtccgc 2712001 tgtactcgat atcaagcagt tcaagcatct gcttgccatt atccgcagcg tcaccgccgg 2712061 aattgttgtt gaacaggaca aaaacatcct tacattgctg ctgcaattca ttcaggtgct 2712121 ttttccaatc ctccagctcc tgttggttgt agcggtataa gtacctgacc tcccgccagt 2712181 ttttcccgcc atcaggcttc atccagccct gcttgttgcg tccgtgaaac ctgacgagcg 2712241 ttttgttttc atcggtcgcg cgcaacacgg tcggaacgct gccttctccg atttgcggtt 2712301 catcacagac actgtgaatc cagccttccg ctttcataaa tgaaagcgtc tgctcataaa 2712361 atggcggcga gaaccaggaa cggtttctga attcaagcgc gcaaggaata tctcccattt 2712421 ggtgcttaca ccatctcaaa taggcgacat tctccttctt gcagtcaaac cacggcggaa 2712481 attgaaacag caccatggcg agcttattgc tatgtaaata tggcgttaaa gacaccttaa 2712541 acgcatcaaa catctcctct tttgagtcaa agggaatttc gccgcgctga tgccctgtca 2712601 tgccctgata tgctttcacg ataaattgga aggtttcggg cgtttccttc acccactttt 2712661 cattattgcg cgccggctga atcgcgtaaa agctcgcgtc taattccacg atcggaaaat 2712721 gggaggaata ggcctgcaat tttttctggc tggccgtttt cggcggatag atgctgtcat 2712781 gatcccccca tcccgtcagt ccgatataaa tcacactcat tcacctctct tccagtttat 2712841 cacacgtgtt ttcaggtttc ctcggaaatg ctgttcatat ggcgggaaaa tgcctcacgc 2712901 aaatgctgat attgttcctc attcgtatct aaaaacgcct cttctcttga ggaaggaatg 2712961 tgctgatatt caataggcgc ctgaaactgc tcactcgtaa aatcgtacac cacaccattg 2713021 atgctgttat aaaaatgcca gctctcatcg actcttgttt tgaaaatcgt gccgccgaaa 2713081 tggtcttgaa tcaccaatgc cgtcacgccg cattggccgc atgacgggca ttcttccgtc 2713141 catttagagc tcgaatggcg cgaccaggat tgcttaagta tgtatttgac atgctccatt 2713201 gcctccgcct cctttaaaaa aagataccac gttgatgaga ttttaaaaac tagaacggag 2713261 gaaatcaaaa aacccggcgg taaaatccgc cgggcttacg aaggaacgac cagagctccg 2713321 tcaatttcag tgactttttc cccatcattg tacacgcacc ggcctttgct gtaagtggcc 2713381 gaaatgctgc agggaaatgt atgtccttcg taaatgcttt ttttatgctt tgcaaacatc 2713441 gattctcttg taacagtgta cggctccatg ctgacgagca cgaaatctgc atcacacccc 2713501 gcctcaagcc gccctttttt ctgaaggccg aatcgttttg caggggccgc cgctgtccat 2713561 tctgcgatgg tttcaaatgg aatctgatgc tcaagcgcca gttccagcat tcctaataaa 2713621 gtgaactgcc cgccgctgat tccgccccat gataaaaaca tgttatcctc ccgcttcaag 2713681 gatggacggc aaggggaatg gtctgaggaa accatgtcaa tgtccccggc aatgagcgtc 2713741 tcgatcagcg tctcttttga ttgccgtgac cggagcggag gcgcgcattt tgcgacagag 2713801 cccctttgcc gtaaatcgtc atggctgaac aagacataat gcggacatgt ttcaaccgaa 2713861 acatcaagac cttcctgttt cgcctctctg atcagccgga ccgctttcgc cgtgctgata 2713921 tggacaaaat gaaccggaca gcctgtcacc ttcgcatact gaatcgtgcg atacaccgct 2713981 tcaacttctg cttcctccgg gcgggaggcg gcgtacgcat ccgcatccac ctttccttta 2714041 ttggccaaaa ccatctgcaa gtagcttgtg atcgcgtcgc tttccgcgtg gagagcgagg 2714101 atttttcctg cagccgcgat ttctgccatg cctttgagca atgtccgttc atcaacagag 2714161 cggaactcat cagtgcctga ctttgataaa aacgctttaa acccgatcgc tcccgcttca 2714221 gccatcggac ggatgtcctc gatatggcct ggcacaaggc cgccccatag cgcaaaatcc 2714281 acggcagatt tttgcctgcc tagctcagct tttgcgagaa gatgctctgc cgtcacggtt 2714341 gatggaatac agttgagcgg catatcaaaa taggtagtgc aaccgcctgc ggccatcatt 2714401 tgagaacctg tttcaaaccc ctcccaatcc tccctgcccg gttcattaaa atgaacatgg 2714461 caatctatca caccaggaaa cacgtatttc ccgtctgcct ggatgatttc cgtcccgctt 2714521 gcttcaatgt cagaacctat ctcggcaatg acaccgtttt gaactacaat atcagcttct 2714581 ataacgccat ctggcgtaac tgccttcgca ccttttatca ccatatcgta agccatattg 2714641 atccccccat gtcaggatga cgattttcca tgtcagttta tgtaacacaa ccagttctat 2714701 tttcaacagt ttactgctac tatgatcgta ttacatcagc aaaaccgcta gaattcctat 2714761 tgaaaattat tcaccttaac caatgttttt atagaaaagg agaatgcgct atgaatattc 2714821 ttgatgtgat gaaaataccg gcttttgaaa acgccaattt aatcgctgga aaagcaggag 2714881 gggaaagaga ggttcagcat gtcaatatga tggacgctcc ggatatcgta gactttttgc 2714941 ataagaatga attgctcgtc accaccgcct atcacctgaa ggatcacccg catcaattat 2715001 ctgaactgat tcggcaaatg gcaaaacgcg gctgcgcggg cctcggcatt aaaacaaagc 2715061 gctatctgga agatatcccg aaggaaatca tcgaactggc cgattcatat gcgtttccga 2715121 tcattgagct tccggaacac atccgactcg gcgatattgt gaatgccaca ctcagccata 2715181 ttctcgatat gcgttctaac gagctgcagc aagccattta cgcgcacaaa aaattcacaa 2715241 accacattat gagcggcaag gggctgcaat ccctcctcaa aaaggtgtca gacatccttc 2715301 agcttcccgt gctgctgctt gaccagcatg ccaaaatgct gtctgcgtct catcagattt 2715361 cagttgagac cgaaaagctg aaaggcaccc tgaataccgt atccgggcca tttttcactt 2715421 gtttctctac aatctcagat cagaaaacat attctgtcct gcctatttat aatcacgaaa 2715481 aaaactgcgg ctacctgctg atacccgaca tggtgcaggc aggcgacaaa ggattgatcc 2715541 tcacgattga acaagcggcc aacgtcattt cctttgaact gctgaaggaa aatgcgctga 2715601 agcagttcag ccggcgggcc cgcaatgagt ttttcaacaa ttttattgag cggacctttt 2715661 cttcagatga cgaaatcaaa aaccgggcga aagaattcaa gctgcgctgg gatcaaaaat 2715721 acatgtgcat cgccggcaaa ctcgatcgca atgacgaatc aatcagcttt acagaaaatc 2715781 agctcgcttc cgacagcgta ttcgaatttc ttgaaggtga attatcagcc ttcccgtttc 2715841 cacctcactt ctttatgaaa ggaaatgtcg gcattattct aatcgaggcg acagacagct 2715901 ggagtgaaat gcacgcctcg gtgatcagct ttttagaaca gtttcaaaca caggtcagcg 2715961 ctcaatttaa acgaaccgtg tcctttggca tcagcaatat ctgccaaaag ctcattgatg 2716021 ttcccgacgc tttcacagaa gcttctgatg ctctgcaatc ggggcatttg tcaagaagca 2716081 ccgcatttat ccaggtgtat cacgccaaag atgtgcctga gcttctgcgc ttgctcccag 2716141 ttgaggattt gaagaaattt tacaactcca cgcttcagag cctcgctgaa aaacagcagg 2716201 aggatcaaag cctgcttcat acgctttccg tctatttaga gacacactgc caaatttcag 2716261 agacggcaaa gcgtctgtac gttcatcgca atacggtcat ataccgcctt gaaaaatgcg 2716321 aagagcttct ggggaaaagc ttaaaagatc ctgaaacaac gatgcgtttg cggcttgcat 2716381 tacgtatgca gcggctgatc agctaaagtt tgttacattt tcttacaaaa cgaatcgttt 2716441 ttcgtcactt tcagcaatca cacctgtctt tttcagctac tgtatccaat gacacccctc 2716501 gaccggaacg atattatgtt actaaagttc acatacaggg agggactata gtgaaaaaaa 2716561 gatcgtttaa ggtgtttaca cttagcctgc agcatgtgct cgccatgtat gcaggtgcga 2716621 ttttggtgcc cctgcttgtc ggcagggcgc tgaatgtaac aactgaacag ctgtcctacc 2716681 tattggcgat tgacctgtta acatgcggcg tcgctacgct tttgcaaacc ttgcgcggaa 2716741 catacatcgg catcgggctt cccgtcatgc ttggcagttc atttgtggcc gtcaccccaa 2716801 tgattgcaat cggcagcaat tacggcattc acgcgattta tggttccatc attgcggccg 2716861 gtgtgttcat ctttttgttt gcgcgttttt tcggcaagct gactgtgtta tttcctcctg 2716921 tcgtaacagg taccgttgtg accttgatcg gcctttcact tgttccgaca ggtgtgaaaa 2716981 atatggctgg cggcgaaaaa ataaacggca gcgccaaccc cgaatacggt tcgctcgaaa 2717041 accttcttct ctctgtcggt gtccttgttc tgatcttagt cctcaaccgc tttctcaaag 2717101 gatttgcccg aacactgtcc gttctgatcg gcatcgccgc cggaacagcg gcagcagcga 2717161 tcatgggcaa agtcagcttt tcttctgtta cagaagcacc gttcttccaa atcccgaagc 2717221 ctttttactt cggagcccct gcgtttgaaa tcggtccgat cttaacgatg ctgatcgtcg 2717281 gaatcgtcat tattgtggaa tcaaccggcg ttttttacgc aatcggaaag atatgcggca 2717341 gacctttaac tgacaaagat ctcgtcaaag gctatcgagc ggaaggaatc gccattctca 2717401 tcggcgggct gttcaatgcc tttccttata atacctttgc gcaaaacgcc ggcttattgc 2717461 agctgaccaa agtgaaaaca agaaacatcg tcgttaccgc aggctgtatc cttgtctgtc 2717521 tcggactgat tccgaagatt gccgcccttg catctgccgt tcctgctgct gtacttggcg 2717581 gcgcgaccgt cgtcatgttc ggcatggtga ttgcctccgg cgtcaaaatg ctcagcacag 2717641 cggatctcaa aaatcaatac cacctcctga ccatcgcatg ctcaatcgca ctcggcatcg 2717701 gcgccagcac ggcccccggg atttttgctg aattccccgc tccgatccgg attctggtca 2717761 gtgacggcac catcaccgga agcctaaccg ccatcttttt gaatctattt ttcagcttgc 2717821 gcgacaaaaa agaattaaca gcacagcaaa cagaacttcc ggtattagaa catacactcg 2717881 cattagaaaa agaggtgtaa aaaagatgaa ggaacagcac aatgccttac agctaatgat 2717941 gctggggctt cagcacatgc ttgccatgta tgcgggagcc attctcgttc cgttgatcgt 2718001 cggagcagcg atcgggctga atgcggggca gctgacgtat ttaatcgcga ttgatttgtt 2718061 tatgtgcggg gcggcaactc ttttgcagct ctggagaaac cgatatttcg gcatcggcct 2718121 tcccgttgtg ctcggatgca cgtttaccgc agtcggcccg atgatttcca tcggaagcac 2718181 ttacggtgtc ccagcgatat atggtgccat tatcgccgca ggactgattg tcgtcttagc 2718241 cgcgggcttc ttcgggaagc ttgtccgttt ttttccgcct gtcgtaaccg gatcagtcgt 2718301 catgatcatc ggcatcagcc tgattccaac ggcaatgaat aacctggccg gaggtgaagg 2718361 aagcaaagaa ttcggctcac tcgacaacgt gctcctcggg tttggcgtca cagcttttat 2718421 cttattgctg ttttatttct ttaaaggctt tatccgctcc atagcgattt tactcggtct 2718481 tatcgcagga acagcggctg catatttcat gggaaaggtc gatttttctg aggttttgga 2718541 ggcgtcttgg cttcatgttc cgtctctgtt ttatttcgga ccgccaacct ttgagctgcc 2718601 ggctgttgtc acgatgcttc tcgttgcaat tgtcagcctc gttgaatcga caggcgttta 2718661 ttttgccctc gctgatatca caaaccgcag gctgtcggag aaggatctgg aaaaaggcta 2718721 ccgggcagaa ggccttgcga ttttgctggg cggcttattt aacgcgtttc cctatacagc 2718781 tttctcgcag aatgtcggca tcgttcagct ctcaaagatg aaaagtgtca acgtcatcgc 2718841 catcacagga atcatactgg tcgcgatcgg gctggttcca aaagcagcgg ccctgacaac 2718901 agtgatcccc accccagttc tcggcggcgc aatgatcgtc atgttcggca tggtcatttc 2718961 ttacgggatc aaaatgctat ccagcgttga ccttgattcg caaggcaacc tgctgattat 2719021 cgcctcttcc gtcagcttgg ggcttggcgc tacaacagtt cccgcgttgt tttcatctct 2719081 ttcgggcgcg gcctctgtct tggcaggaag cggaattgtg atcggcagtt tgacggccat 2719141 tgcactgcac gctttttttc aaaccaaaca gccgaatagc gcagacataa aaacgtaaag 2719201 gaagatgcca atgttcacaa tggatgacct gaaccaaatg gacacacaaa cactgacaga 2719261 cacacttggc tctatttttg aacactcttc atggattgcg gagagatccg cagcactacg 2719321 gccgttttcg tccctttctg atcttcaccg caaaatgact ggcattgtaa aagctgcgga 2719381 tcgcgagaca cagcttgatt taatcaaaaa gcatccccgg ctcggaacaa agaaaacaat 2719441 gagcgatgac tcggtacgag agcagcagaa cgcagggctc ggcaaattag aacagcagga 2719501 atacgaggag tttctcatgc tgaatgaaca ctattatgat cgcttcggct ttccttttat 2719561 tttagcggtg aagggaaaga cgaaacagga cattcaccaa gccctgctgg caaggcttga 2719621 gagcgaacga gaaacggagt tccagcaggc ccttatagaa atttaccgaa tcgcccgctt 2719681 tcgtctggct gacatcatca ctgaaaaagg agagacgcaa atgaaaagaa ccatgtctta 2719741 tggcaaagga aatgtatttg cataccgaac gtatttaaaa ccgctcactg gagtgaagca 2719801 aatcccggaa tcatcttttg ccggaagaga taataccgtt gtcggcgttg atgtgacatg 2719861 cgaaattggc ggagaagcct tcctgccatc atttacagac ggagacaaca ctctcgtcgt 2719921 ggcaacggat tcaatgaaaa actttatcca gcgccatctc gcatcctatg aaggaacgac 2719981 aaccgagggg ttcctacact atgtagctca ccgattttta gatacctatt ctcatatgga 2720041 cacgatcact ctgactggcg aagacattcc gtttgaagca atgcctgcat acgaggagaa 2720101 agagctcagc acaagccgcc tcgtcttcag aagatcgcgt aatgaacgaa gccgctctgt 2720161 gctgaaagca gaacgaagcg ggaataccat aacgattaca gagcaataca gcgaaatcat 2720221 ggatcttcag ctcgtcaagg tgagcggcaa ctccttcgtc ggcttcatcc gggacgaata 2720281 tacgactctc ccggaagacg gcaaccgccc gctgtttgtc tatttaaaca tcagctggca 2720341 atatgaaaat acaaatgact catacgcttc tgatccagca cgctacgttg cggctgaaca 2720401 agtccgcgac ttagcgagca ccgtttttca cgagctcgaa accccttcaa tccaaaacct 2720461 aatctatcat atcggctgca gaatattagc gaggttcccg cagctcactg atgtcagctt 2720521 ccaatctcaa aatcacacgt gggatacggt tgtcgaagaa atcccgggct caaaaggaaa 2720581 agtctacacc gaaccgcgcc cgccatacgg tttccaacat tttaccgtga caagagaaga 2720641 cgccgagaaa gaaaaacaga aagccgctga aaaatgtcgg agcctgaaag cctgatggga 2720701 aaactgacaa cccatatttt agatttaacc tgcggcaaac cagcggcgaa cgtaaaaatt 2720761 ggattgaagc ggctgggcga aagtattatg aaagaggtat acactaacaa tgacggcagg 2720821 gtcgatgtcc ctctgctggc tggtgaagag ctgatgtcag gagagtatgt gatggaattt 2720881 catgcaggag actattttgc gagtaaaaac atgaacgcag ccgatcagcc gtttttaacc 2720941 atcgtcaccg tccgttttca gctagcagat ccagatgcac attatcatat cccgctcttg 2721001 ctgtcgccgt ttggttatca ggtgtatagg gggagttaag aaggaagccc gcctcaccgg 2721061 cgggcttctt tttgcacttc aattaacttt tgatcctagg acagtacttg aagtgatccc 2721121 cacacttagt gaaacaacag ctagaataaa cattcaccta tatttttcag gataattgcc 2721181 tacgagaaaa ataccctgta gtcctttcat ttataaatcg aggtttcaaa ctaataagtc 2721241 agctcttagc agccgagctc ccttctccaa tcctataaac agaccgcgtt ttttctcgaa 2721301 aaaatactct gaagacaatt gctgcgtttt taatagtttt gataacgcgt tctctcttac 2721361 acctttagac aaaatattca ttttttcttt tttagactta aatctatgtc gaaaataatc 2721421 gttggcatat cttatcctat ctccactaaa ggaggtgaca ttatgggatt ctacaattct 2721481 ggtggataca gtggaaactc tggttactca aacggtttcg ggagctcctt cgctttgatc 2721541 gtggtgctat tcattttgtt gatcattgtt ggagcagcta tctttaatta ttaagtttaa 2721601 ctttccttgc ctccgccgta tccaacacct ccctgtccga cagacgccat aagaagtttt 2721661 tatggcgtct ttgctatgtg ttcactaatc tttttgtaat ccagaagctg tcaagttcta 2721721 cgagatttat cgtgtgtttt cccacaacgc ttctgcgtct tgatcgcgct gtctgactga 2721781 ggctaaaaaa gtccggcttt taaaagccgg actcccgtct acccccgttc aactctcttc 2721841 taatcctgca agctgaccgc ataatcccgc catacccggt acaccggcac aaattccccg 2721901 ccagcccttc ttctatatct ttgtcagaag gttgaggggt ttcccgaaac aatgctttaa 2721961 gcgcaatgat cattcccggc gtacagtagc cgcattggaa gccgccttct tccaggaaag 2722021 cggtttgaca catatccagc tcttcttttt gaagcccctc gatggttgtg atggaatggc 2722081 cgtctgcttg ataggccatc gtcatgcacg cattggccag ttttccgtcg attaaaatag 2722141 agcaggctcc gcagcggccg attccgcagg acacctttgt cccggtcagc tgaaattcct 2722201 ttctaagcag gtcactcaga tgtgtcgtag gaacggcagc aacctcccac gcctgaccat 2722261 tcacggtcat ccggaactgt tcctttttta caggaaatgg cccggcctct tttatgtcca 2722321 ttgcttcagc ccctttctgt cgatcgcttc aagcaactct tctcttgaaa ttggcagctt 2722381 gtttatccag catccgaccg catcatgtac tgcctttaca atcgccggag tgatggcgat 2722441 tgttccgatt tcaccaacac cgcgcggtcc atatacgtct cccttcatta agtcttctat 2722501 tgcaatcagc ttcatgtcag gaacatcttt gattccggga atcaaatagt gatcgagatt 2722561 ttccgcagca taacggccat ccgtcatttt cgcttcctcc atcagtgtgt agccgagtgc 2722621 catggcagcg ccgccttcaa tttgacctcg atatccctgc ggactgacaa ccggacctgc 2722681 cgcaatagcg tgctcacaat ctatcaattt gacatcgcct gttaacagat ctacctccac 2722741 ctcaacggca gccgctccaa atgagtagag gaaatggccg cccaccacag gatcaggcgt 2722801 tgttggaaag tcaaaggccg tttcctctgc caaagggcct ttttcagcca gctccttata 2722861 cgtcaccacg agcgcctttg tgtttttgtc acgcaagcct gcagcgccgg gaataagatt 2722921 ttccgctgaa cagccgctcc attctgccgc ccgttttttc aactgagcta gaaacggctt 2722981 cttcaaacgc tggatcgcgt gccacaccat gcttgtgccg cgggatgctg tggaggagcc 2723041 tgacttcggc acttttgcgg tatccccaat aacaatggaa atatcctctg cggcacaacc 2723101 cagctcctcc atgacaatct gttcaatcgc tgctagaatc ccctgtccgc attcttcaaa 2723161 tccaaacgaa gcagtgattt tgccttcact cgaaagagac aaacggcctc ctgccgcatc 2723221 cattcggcca aaccccagcc cgccgccgtg cattgtaatt gccgctcccg tgcctctttg 2723281 cagatacccg cagttccggc ttgttttttt aagaatggga gatttagata tggcattcaa 2723341 cacctgtgcc gctccgtcag ttggtgcaat tcgatgctca agcggcccca agtcatgcgg 2723401 ttttctgata ttttttcttc tcagctcgag cgggtcgatg ccaagcatgc cgctgagacg 2723461 atcgagatgg gtttcgagtg caaatgtgat ttggttgccg ccaaagcccc gaaattcccc 2723521 cgccaccccg ttgttcgtaa atactgatat tccttcagtc cggatattcg gaatacggta 2723581 cggccccgcg gcatgctcga cagaaaaatc aagaacagcc ggtccgagcg tagcgtaagc 2723641 gcctgtgtcc gccacaattt tcacgtcgtg cgccaataga tttcccgaat gatctgcacc 2723701 cgtttttatc gtaatcttca tcggatggcg cttaatgcca gaacgtacag attcctttcg 2723761 tgtctgatga attttgacag ggcgtccgct tttcagggcc aaaagcgcag catacggctg 2723821 aatattcagc tcatccttcc ctccgaacga gccgcccatc ggacttgaca caattctgat 2723881 cttctcttca ggaatatcaa aaatacgggc aagctggaaa cggtctttat agccgtgctg 2723941 ggttcctgca tacatcgtaa aacccccgtc gtcttccgga acggctacac ctccctccgt 2724001 ttccatatac gtatgcatct gccgcggcag ctcataggtt tcttcaaaga ctgtgtcaga 2724061 tgcttgaaac ccttcttcca catcaccgtt tgaaaaaaat gcgcggtgca ggatattccc 2724121 gtcctcatgc agtctttgcg cattcggccg aagcgctttt tctggtgaat ccatgacttc 2724181 cagctcttta tactcaactt gaatcagctc cagcgccgct tccgcgattt cttccgtttc 2724241 cgcagcaact gcggcgatcg catccccgac ataccgcacc ctgtcctcac ataaaaccgg 2724301 ctgatcaggg atgacaatgc caaatcggtt taagccggga acgtctttat gtgtgacgac 2724361 ggcctgcacg ccttccattt tctcagcttt tatggtgcaa accgacacaa tctctgcatg 2724421 aggataagca cttctcagca ccttgccata cagcattcct ggaaagctga gatcggtcat 2724481 atatttcaat tcccctgtga ccttacccct tccatccggc ctgactcttg acggtttgtt 2724541 gatgatcatt tattcccctc cctcagccat cagctctgcc atgatgacgt tggcagcggc 2724601 tttttttctg tatgccgctg acataaaaac atctgaggaa aacggcagct catggataag 2724661 tgttttgtac agctcatgcg ggtcccaccc tggtgccatc catttcgctt cgctgtccaa 2724721 taatctccta ggagtgatat cggcatggcc agcggcgagg cgaatgctgc cgtctttcaa 2724781 aaaacgtcca gctgcaacag cagccgctcc ggtaaaagcc tggcgccttc caagcttgtg 2724841 ataaaataca cgctctccct ccgcccgcgg gatgatgaca cgcgtgacga tagccgttct 2724901 aaagtcttcc tcactgagcc aagcgccaag cggcagcctg attagctcct tttgatatac 2724961 gataagctca gcaccaagca caagcagaag cggaatgaaa tcaccgattt tactcgctat 2725021 gttgccgcca atcgtggcac ggctgcgaat ccccggtgca gcgacagcgg aagcagcgtc 2725081 actgaaacag ctaagcgctc tcttaatcaa agggttcttt ctgcattcat tcagtgatgt 2725141 gagccccccg atcgacacgt gggtgtcact ggtgctgatc cctcgcattt cgtcaatccc 2725201 ttcaaggctg acaaggtgct gtttcggtag agttcctttg tcccactgaa gctgaaggag 2725261 cgtgcttccc gatgcggcac acacatccgg agcaagcttc tctaaaagcg aataggcctc 2725321 atcaagcgct gccggtctcc ataattgaat attcatcctt gcttttgtca cttggccgtt 2725381 caagacatcg ccctccttac catgtcatat tcctcgggtg tatcaatatc gtccaactca 2725441 ccgctatcct ttgcctccaa aaccgctcct gctccaagct gtccgctttt caggagcctg 2725501 cgagcccctt catctccctt taatcccttt acataaggaa aacatgtcga cgagaagtag 2725561 attggcgggg tgaacgcccc taaaaacgat gacacggcaa atgactcagg agccagagcc 2725621 acaagggcat tgagatgatc gacggaaagc tgaggctggt cggctaacaa aatgacaatg 2725681 ccgtccgccc ccatgctttc tgcttttctc accccgctgc tgactgaatg cccctgaccc 2725741 ttttctgcgt cttggcaaac gtgcaggctc cagcgttttt gaaaaggcgg agcgtgatac 2725801 ggcgctccta tccactcaag ggaggcatgt tctgtccgct cgacgaccag cacgtgatca 2725861 aggcgggacg acagagcagt tttcaaggaa agtgagccta tgttttctcc ttttagcggc 2725921 aaagccagct tgttttgtcc cattcttctg cttttgccgg cagcgagaaa cacgccgatc 2725981 agataggggc ttctcataca accgccaccc gttttcttgt ttgaatgatt tctgcaacta 2726041 cacttaccgc aatttcctcg ggaccttccg caccgatttt cagcccgacc ggactgtaaa 2726101 agtgagacgg aggatgtttt ccgctcagca gccgtttcgt gcggtttgcc gaacccaaca 2726161 gtccaatata atggaggttt tgagaaaata agaagttgat gatcgtttga tcgtgctgat 2726221 aatgatgggt tgccacaaca gctgcatcat gcggaaaaaa ttgaaattcg ctaagcattt 2726281 gttccggaaa agcggtgatc agctgatccg cttttggaaa aagagaggat gtacaataag 2726341 cgggccgcca atccgtcacg ataacagaaa accctgtgtc agccgccaaa ttggccagcg 2726401 gtacattatc cggtcccgcc ccaaacagaa tgagacgcgg cttcggttca attcgctgaa 2726461 taaacatgtt agtggtttga tcgaaatgcg gtaaatgaag cgttgaaaca gtacgttgaa 2726521 tatcttgcag aggcgcgtcc ggccagttcc caaaatgtcc gttctccgtc agaaataaat 2726581 aatgggagga ttcaatcttt ataacggaag tgacagcttt gcctgaatga aggcagtccc 2726641 tcactttctc atagtgccgc cttttttcct gagtgattcg ctctgcatga acatgaataa 2726701 tgccattgca cccggctccc atgccccaag aaagatcgtc ctccgaccgc atgtcgtagg 2726761 gaatcagcgt tgatgtgagc tgatcgccca gcgcactgat tctttggaat acatcttctt 2726821 ccacacaccc gccgctcagc aagccaatcc gtctgccttt tttcttaaag agcatagagg 2726881 cgcctgcttt tcgatacgcg gagccttcaa cttgaacaat tgtcgccagt acagcctcct 2726941 cctggtcttc caggagcgca tctaacatcg tgtgaaaatt ccccaatgcc gcatcctcct 2727001 ctcgaaaatt gccgtgagaa acaactagtt cagcgtgatt ttataggtaa cttgtataaa 2727061 gaatagacga tggaagaaaa aatgactcat gatttgtcag aaaatgaaac acatagaaag 2727121 aggatttgta aaaagagtca aacgaagaaa atcagattgg agaaaacacg aaatcatatc 2727181 gttaaaaagc ttgcggagtt ccgcaagctt ttctttacac cgctgcctgg cggccagcgt 2727241 tttcatacac atccagcgct gcttggagcg cttttcctgc ttcgattcct gcgttatgtc 2727301 tgagaagcac agcctctaac ccggcaagca cgaatagcac gttttctttt ctgcagctgt 2727361 accccatcgt gccgatcctc cagatcttcc ctgcaagcgg gccgaatgag ctggcgattt 2727421 caatgccgaa ttgtgccagc agcatgtcac ggacagactc gccgtcaatg ccgccgggaa 2727481 tttcgacaca ggtgacaaca ggcattttgc agctgtcatc tccaaacaat cttagcccca 2727541 ttgcctttat ccctgctgct aatgcggctt catggtgccg atgccgctcg aaacgcgtct 2727601 caagaccttc ttcaagcacc agtctgactc cctcacgtaa ggcgtacagc atcgtcgtcg 2727661 cttctgtatg atgattgagc cgtctttcgc tccaataatc ctcaagctgg ctcaaatcaa 2727721 agtagttgct tgtaattggc cgatttcccg aaagtgctgc cctgtcagct tgtgtcgcaa 2727781 tcccgcgttc cacctttttg cgagctgcaa tcacgtccgc cacccgctca ttatatgtaa 2727841 tcggcgccat tcctgaaggc acagacaaac atttttgcgt tccgccgatg gcagcgtcaa 2727901 tcttccattc atcgacttta acctcgcagc ccccaatcgt tgcgactgca tcgacgataa 2727961 acaatgcatc ctcggtgcgg caggcttcgc cgatggcttt cagcgggtga atccgtcctg 2728021 tcgatgtttc tccatgcacc atggccacaa ttttcggctt cacttttttt atctcccgta 2728081 tgatgtcctc cgggtcaaaa accgttcccc attcgcactc cagcatatga acatttgccc 2728141 catatcgctc ggcgatttca gtcagcaaat aaccgaaacg gccgtaaatg ggaatgagca 2728201 catcatcttc cggctctatc acactagcca gcactgcttc aattcccgcc cgtgaagtgc 2728261 cgtcaatcgg gtatgcccag cggttttttg tttggaacag ctcccgaagc atctccatcg 2728321 tttcattcat aatacctgta aacgccggat caaattggcc gacaaccggg gtgctcatta 2728381 ctcttaatac acgcggatca acctcaacag gccccggtgt cataatcgtt cttaacgggg 2728441 tgcataattc tcttctgcct gacacagcca ttcctccttt atcagtaagc cagtttgtat 2728501 aataaatcag tcagtgcgcg gacgccgatc tcaagctgtc tggctgacgt atattccttc 2728561 ggtgagtggc tgacgccgcc tcggctcggc acaaacagca tacaagcagg atagcgcctt 2728621 ccgatcattt gcgcgtcatg ccctgctccg ctcaccattt cctcacagct gaagccgttt 2728681 tctaatgctg tttcaaaagc cgcagccttc agcctttcgt ccatcggcac aggctctatc 2728741 cgcatatatt catcaatcac agcgcgaatt cctttttgta ggcaaatgcc gttgatcaaa 2728801 gcaaccatgt cttgatgaaa ctgttccagc acatgctgat gctgatggcg aatatcgatt 2728861 gaaaactgga cgcggcccgg tatgacattg gctacattgg gctctgccgt tatttttccg 2728921 catgtcagac ggagctcatc cggcagctca tccgaccgca gcagcagctc atgaatgata 2728981 cggctgctgg ctgcgagcgg gtccttgcgc catttcatgg aggtggttcc tgcgtgattg 2729041 cattctcctt cgagcgtgac gagatatcgt ctctgccccg caatacttgt cacgatgccg 2729101 agatcccggc ctgacatttc caacgtcttc ccctgttcaa tatgcagctc aacaaacgcg 2729161 ctgatatctg tcctatatgc tgactgaaac acacctttgc caaaaccgct ctcatgcatc 2729221 gctgtttgga gggagactcc cgactcgtct cttggctctt ttgcatcttg ttctgaaaaa 2729281 acacccgtca tattccccga cccccaatag gtcattggaa aacggctgcc ttcctcctca 2729341 cataaggaga ccgcctcgag cgtttttttt ggcgctccgt atgtttcctt gagctgcttt 2729401 aacgcgagca ttgccgccag aacgccatag gcgccgtcgt attttcctcc attgatgaca 2729461 gtatcgatat gtgaaccggt tacaatgact tcatccggag actgggtgcc cgaaagcctt 2729521 ccaaacacat tgccgacatc gtcgaatctt gtttcaagcc cgaaagaaga catttccgtt 2729581 ttcacagcaa gctgtgcgtc catccactct tttgtgtata aaagcctcgt tacgccgcca 2729641 tccgcagacg caccgtattg ggcgagccat tcaatataat ctgtgatgct gttttttact 2729701 gaaagcttct gcttttccat gtactccccc ctctggccgc tatggtgact tcattataga 2729761 aggagcaaca tgatagttca ttgacagatt aaccaaaaaa acgtttattt tttagccaca 2729821 gtatccatcc agcaaccaga tacaccctac atgtcacaac tattttgatg taaaggtcaa 2729881 aagaaaacac ggtaaggaag agagccagca agagcgaaag agagggtcaa aatgcctttc 2729941 atatgaacaa gctaagctgg agaggcgatg ttcgcggaac ggatgaaaac agaaatgccg 2730001 gcagcccgca aaaacaggac ctaaagatat ggaaacagga gatttccgcc tcctccaaag 2730061 ggactaattt acaattttaa tgaaaaatat acaaaatgac acttctatcc tttatttcaa 2730121 ttttagataa tagatatgat ctgataaaag gagggcaagt gatgacaaaa aaagcatggt 2730181 ttctgccgct cgtctgtgta ttactgattt ccggatggct tgcgccagca gcttcagcaa 2730241 gcgcgcaaac cacattaagc cttaatgacc gattggcgtc ttccccttca ggaacgggaa 2730301 gccttctctc attagccgcc cccgctgcac cctatgctga cacagatacc tattatgaag 2730361 gggctgaagg taaaacagga gactcgctaa aaagcaccct gcaccgtatt atcagcggac 2730421 acacgatgct gtcctacagc gaagtgtgga acgcgctgaa agaaacggat gaagacccaa 2730481 gaaatccgaa taacgtcatc ctgctctata cgaatgaatc gcgttccaaa aacctgaacg 2730541 gcggcaatgt cggcgattgg aaccgcgagc atgtctgggc gaaatcccat ggcgattttg 2730601 gtacgagcaa gggacctggt actgatattc atcatttgcg cccggctgat gttcaagtta 2730661 acagcgccag aggaaatatg gattttgaca atggcggcac tgaatatgcg aaggcacccg 2730721 gaaattatta tgacggcgat tcatgggagc cccgcgatga tgtgaaaggc gatgttgccc 2730781 gcatgctgtt ttacatggct gtccgttacg agggtgatga cggctatcct gatcttgagc 2730841 ttaatgataa gacaggcaac ggctcagctc cttatcatgg caaacaatct gtcctgctcg 2730901 aatggaataa gcaggatccg gttgacgacc gcgagcggaa aagaaatgaa atcatttatg 2730961 aaaaatatca gcacaaccgc aatccattta tcgaccaccc tgaatgggcg gatgagattt 2731021 ggccgtaaga aaaaggtgct ccttttgagg agcacctttt tctaatacac agcctcttcc 2731081 gtttccgcat cgaaaaagac gacgtggtcc attttcactg agagctggat tgaatcgcct 2731141 gcatcgattc gcgtgtttcc gtccaggcgg accttgagcc gctcgtcccc agccatgaca 2731201 tgcactatga gctccgagcc cagattttca ttcacttcca cgttcgcttg aaacactgaa 2731261 tcaaacaact ggtcatttcc tgtcatttgt gtgatgtgct ccggccgtac accggcaatc 2731321 atctgttctc cggcatatcc cttttccttc agccgctttg ctttttcttc aggaatatga 2731381 agccggatcg aagaatttgt gaaaaacagc tcgccatgct gctgttctat gatgcctttc 2731441 aaaaagttca ttccgggaga gccaatgaag cctgcgacaa acaaattggc cgggtaatga 2731501 taaatgtcat gaggtttcgc cacttgctga atttcccctt cattcatgac gacaatccga 2731561 tctcccattg tcattgcttc ggtctggtca tgcgtgacat aaatgatcgt tgcctctaat 2731621 cgctggtgca gcttgctgat ttctgtccgc atcgtcactc ttagttttgc atccagatta 2731681 gaaagcggct cgtccattaa aaagaccttc ggctccctca caatcgacct gccaagcgcc 2731741 accctttgcc gctgcccgcc ggagagcgcc ttcggttttc tcttcagcaa atgttcaatt 2731801 tctaaaattc tggctgccgc atgaacccgc tcggcaattt cctgtttcgc catctttctg 2731861 agctttaatc caaacgccat attatcaaaa accgtcatat gcggataaag cgcatagttc 2731921 tggaatacca tcgcaatatc acgttctttc ggcggaagat cattgacccg ctccccatca 2731981 ataagaagat ttccttcaga aatgctttct aatccagcca ccatccgcag cgttgttgat 2732041 tttccgcatc ctgacggccc caccagcacc aaaagctcct tatcctttac atctaaatca 2732101 aagtccttca cggttaattg tgagtgatat gattttttga cgtgttcaaa tgttaatgaa 2732161 gccatcagaa aagtccccct atcttttgac ccgttatttc gtcactggaa acaacttggt 2732221 ctttctgtta tttttagagt aatcgattcc catttttgct atatttctaa aataaaaaat 2732281 gtaaatttgt attataacgt cataatacat tataatataa ataataggtt aaaaggaggc 2732341 taccctttgt taaacaacgg aagttctaca cctttataca ttcagctaaa acaaatcatc 2732401 actgatgaca tcaaaaaggg cgtgtattcc ccaaccgcca agctgcctac cgaaaacgag 2732461 ctttgcacca agtataacgt cagccgcatc accgtcagga aagccattct cgatttagtc 2732521 gaagaaggct atctgatcag gcagcaggga aagggaacgt tcgttaaaag ccctaaatta 2732581 aaacgagagc tgatcgctgt aaacggctac tcggaattta tggaatcaac cggcaaaaaa 2732641 ccgaagcatc atgtgctgtc ccatgacatc attccagcgt caaaacccat cgccgaaaag 2732701 cttcaaatcc aacccgagag ccctgtggtt gaattaaaac ggattttata taatgatgat 2732761 cagcctctca cctttgaagt gacgcattat ccgcttgatt tgtttcccgg cattgatacc 2732821 tttattgctg acggcgtctc catgcatgat attttgaaac agcaatacaa agttgtaccc 2732881 acgcacaata cgaagctatt aaacgttgta tatgcccaac aggaggaaag caaatacctg 2732941 gattgtgata tcggggatgc gctgtttgaa attgataaaa cggcttttac atcaaacgac 2733001 cagccaatct attgctcatt gtttttgatg cacacaaacc gtgtcacttt taccatcaac 2733061 agcccctaca cataacaggc ataaaaaacg agacactgct tatagtattc tcgttttttc 2733121 actgcttccc ccgtcctcca agcgataagg atagccatag ccgaaagctc cgtacacacc 2733181 gcaagttttc gcagccgttt cagcagcctg gcgcaaagca tacgttatat cctgcttcac 2733241 gcaaaaggca gtcaaaaagc ctgctataaa agaatctccc gctccaagtg tatctattat 2733301 atcagcttcc acaatcggct gatgatagac tcgatcaccc gcagacagga ttgctccttg 2733361 gccccctcgg gtcatacaaa ccattttggc tccgtaccca tgagctgttt tggcaagctc 2733421 accgcattcc gactcactca aatcgcttcc tgaaaaaaac gcatacgtca cataaggaca 2733481 gaccctcctc aaataatcat cctcccgatt ggttgaaaaa tcaaatgaga ccgggaccag 2733541 cccgcacagc tgcggaagat cgttctcaag cctgctgtac acgctcgtat gcagcagatc 2733601 atgcccgctg ataaaagata catctttctc ctgaaacgcg aggcgaagcc gggactgaat 2733661 gccgccttta tttgatctga caaaaatgcg gtccccctgt tcatcaaggg tgacaatcgc 2733721 catcccgttt tctccgtgcg cctggcggat ataatctgca ttgacctgct ccagcttgag 2733781 aacgttcaac agatgcgccg cggcttcgtc attgccgacg attccgatat aggaagactc 2733841 atgcccgagc cgcttggcaa gcacagcaac gtttaaggca tttcctcccg ggtaaaatgt 2733901 ttcttgatcc tggtagtaat ctacaacatt atctccaacc gcaatcaatt tcatagcgct 2733961 tcctccttta tccttttaca ctgccgcttg caatcccgcg gacaaaatat ttctgcatca 2734021 ataaaaatag aataataatc ggcgcggctg aaatcgttaa ccccgccagc aggacgcccc 2734081 agtctgtctg cagcgcgtct ctgaactgca tcagcccggc tggaatggtc cgtaaattct 2734141 catcatctat gaaaataatc gcaaacataa actcattcca tgtatggtaa gccgtcaaaa 2734201 tgccggatgt caccaaaatc ggcacgctca ttggtaagaa aattctgaaa aatactccaa 2734261 aacttgtaca cccatccaaa taggccgcct cctccaattc ttttgaaata gaaagaaaat 2734321 aagagcggat caaaatgatg gtgaatggga tccgataagc cgcatacggc aagattaacg 2734381 cccaatacgt attgtacagg cccagcgact gaataataga ataaagcggc acaagactga 2734441 cctgcggcgt cagcatcaat ccgccaagac atagcaccaa aaagaatcct tttcctttaa 2734501 actcaaaccg ggaaaggcca tacgctgccc atgcactgat aaagacagtg atcacacacg 2734561 tcagcgccgt aacgatgaca ctgttcataa aataagaaga aatcccctga ttccaggcgg 2734621 aaacaaaatt ttccggatgc cacgaagacg gcagcgacca gctgtgctca aaaatatcgt 2734681 cagagttttt aaaggcgctc atcaccatcc agagaagcgg ataggcaatc gcaatcagat 2734741 aaagaaacag aaaaacccac acagacgttt ctccgatata ccattttcgt ctaggcttat 2734801 ctttcacctc aatgtgctgg tcaggcaccg gctccaatct gaacgaatct gtcttcttct 2734861 gaggcagcat cagttactcc tcctttccgg ttttaaagaa cttcatttgc atgagcgata 2734921 atgcaagcgt aatgattaac acgacagtgg caatcgctga ggcgtagccc atcatatcct 2734981 ttgtaaaggc gcttttatat aaaaacgtgc tcaagacttc tgacgctttt cccggcccgc 2735041 cgcctgtcaa aatgtacggc tcattaaaga ccgtaaaggc tccggtcagc gtcatgacca 2735101 ccgcaacaaa agacatctct ttcgtctggg gaacagtaat atgaaaaaac tgctgaattt 2735161 tacccgcgcc gtcaagccgg gccgcttcat acagttcatc cggtattttt tgaatcgaca 2735221 cgatgtacag catcgcaata taaccgacag attgccactg ggacacaaaa atgacagaaa 2735281 gcatagctgt gctgtcatcc ccgagccagg ccctcgtcag ctgatcaaga ccgatggcct 2735341 gaagcagctg attcaaaagc cctgtctccg gattgtaaat aaaatcaaac aaaagcgcga 2735401 tcaccgtcat tgagatgaca accggcaaaa agaaaacggt acgaaaaaac ggcgaccatt 2735461 ttctgaccag cttatcctca agcaccgccg ccaaaatcaa accgccaaat acctggcata 2735521 caattgagat cactgcataa agcacattat tggtaagtgc ctgatagaag acaggatcat 2735581 gaaataattc aacatagttt tttaagccga taaacgtttt ttccggagaa aatgagctcc 2735641 actgaaacag gctgaggaat acattctcaa aaatcgggat ataaacgaaa agtaaaaaaa 2735701 cgagagcggg caccaaaaac aaatagggga ttattttatt ctgattgacc aagggtatct 2735761 catctccttt ataaaaagaa aaggtgcgaa gcttcacctt ttctttgatt tattcagctg 2735821 acgccctcac ctgctttgct gccttttgaa cggctttcat cacctgctgc ggtgtcatgt 2735881 cgccgccaag catttgctgg acgcccgtta ggtacgcatc tgcgacttca acatcgacat 2735941 ccatatcaaa ccatggaacc attgatttgg catcaacaat atgctgaacg gcttcacgct 2736001 gaatggctgt tgcattttct tcagtagccg taccttgcac tgcactgtat ttcccgacat 2736061 ctttcacgag cttttcgccc attcttttcg acgtcaagaa ctgcaaaaat tccatcgctt 2736121 ccttcggatg ttttgttctt gaggagatca tgaatccttc cggcgctccc gttaacgctt 2736181 ctgaagatcc tttctgcccg ctgatttcag gaaatgggaa catcccgaga ttaaccggtt 2736241 caaccagctt gatttccgct gtttccgcat atatcatcgc cgactttccg ctcttaaatt 2736301 gctgtctcac atattcgtgg tcgacggagt ttacatgttt attaaagtaa ggcatcagct 2736361 cttgaagctt ttcaagtgct tttacgtagc cttcatcagt aaattcaccc gttttggcgt 2736421 tatagtcctt ttcccgtgtt ttttcatcga ccatccgctg attaagcgtg ccgatatagt 2736481 gcgagattgt ccaagtcgcc tttgttccaa agctgatcgg tgtgtagcca tgttctttca 2736541 gcttttttga cacatcgatt aattcatccc acgtcttcgg gggatcaaga ttcagctttt 2736601 ggaaaatgtc tttattatag aagaatgatt tagcgtccat ttgccacggt acgccatatt 2736661 gcttgttttc ataagtaaat ggtgtaattt gcgattgaac gagctgtgat gaccaatcgg 2736721 tgtcattttt gtagtaggac gagagatcaa gtgctttatt gcctctgata aatttaaaag 2736781 caaactcatc gctccaagag aagtaaatgt caggagggct ggtggttccc agcatgacct 2736841 taattttatc tttataggag tcatttaaaa cggcttcaat ttgaatgtcg atatctgggt 2736901 gatctttttc aaattcctta acaacctctt caaaataact tttttccggc tcctttggcc 2736961 atctgtggaa aaatttcaat gtcacctttc cgtccgctga actgctttgg ctcgaacagc 2737021 ctgcgatggt gagcatactg acagctgcaa tgatcaagaa caacaacatt ttcttcaaag 2737081 ggttggcctc ctctggacat tagactataa tgttatataa cattatagtc taatgcataa 2737141 tggttcttca ttttcagatc aatactcaac tttccacatg tatcttctat gagataaagg 2737201 atgatttctc tcctctgcca gctcgtctgc atagcttctc agcacacgat tgagaacgag 2737261 cggagcaaga tagcctttaa ctgaatcgtc aattgcagtg aagtcgtaag atgcagcatc 2737321 aagcacagtg agctttttgc catacttttt cgagaaggta agcgcccgct cttcaagagg 2737381 tcttgtttca tctaaaccga gcaggatgat aaacggcacg gattcatcaa taatttcaaa 2737441 cggtccgtga aaatattctc cggcatgaat ggcgtgggaa tgaatccatt gcatttccat 2737501 gagaatgcag atgctgtagg agtaagcgac accgtagttt gcaccgcttg ccatggtata 2737561 aataatgctt tctttttcat gggcttttgc aaattgcttg gcgttgtcag cttcctgctt 2737621 aagggctttt tcatatacag cctgcaattg atctaagcct tcaattgctt gctcaaattt 2737681 cgtattgttt tctaatactt gcagggttcc aaaaacgatt tgatacaaaa cgccatagtt 2737741 tgtattgatc gcaagcgcct catcacccca atcgtactgg gcaacatatt gcgcttcctg 2737801 cgctaaagga gactccggtt taaacgtcat cgcaatcgta agtgcgccct tgccccttgc 2737861 aaacgcagca gctttgactg tctccggggt atttcccgaa tgcgagcaca aaataacaag 2737921 agacttttca ccaagctgaa cagggttgcg ctgaataaat tcgttggcgc tgtagagatc 2737981 ggagtttatt gattttgact ctctgtcaaa cacatactta ctcggataca taatggcaga 2738041 agaccctccg catgcgacaa agaatacatg atcaatggtt ttccctttca aatcctgcaa 2738101 gaaagcttga acctcacgat ttacttttgc tgtggcctga ctcaaatcct tcactcctcg 2738161 tttttattat ataacgttat ataacattat atattgttat attaaagtcc gcgggtagga 2738221 ttgtcaatat tattttctga aatttctcaa taatttattc ggatgacaga caaagggtct 2738281 atatgcgaaa aaatgcccaa atcaaaagcc agaacttgac ttaagctctg gcttcgctgt 2738341 tcaatccgca gactgacgtc ttatttaaaa aataccttgt ctatattgta cttcgagtgc 2738401 tgtgtattga tgatatatgt ttcgtaaatc tctctttcca ttggatcatc aactacacat 2738461 acctcaattt tataaacttc atctctgtga tgtttgatcg gtgaaacagt gtcttcgaaa 2738521 tgcttcttaa ttctctgtct taactttctg gctttaccga caaacagcag ctcgtcatga 2738581 atgttgtaaa acataaaaat gccgcctttg tcccttggga tctggtgaaa gtcgatgaat 2738641 ccgtgaatcg gttttatctt cggctcgtta tcattagctg actgctgtcg ttcagtgatg 2738701 gtgacattcg gtgcgggtat atcaattttt atcaaaatca gttcacgtcc tctttttcat 2738761 taaagataaa tgctaacaca tacagaaaag aaaagctaga acagctttat tatatttgtt 2738821 tgtcatgctc ttacttatta tgcaagtgct ccggctggat cataaggact aaggtctaat 2738881 tctgtctgct ttccgagaac tagctttgcg agctctgcac ccaaaaacgg ccccatcgtc 2738941 agtccagaag cacccaaacc gtttgcagcg tacaggcctt gaacattcgg cacggcccct 2739001 acgaccggca gaaatcccgg tgtaaacggc ctgaagccca ctcttgtttc aacagcagcc 2739061 gcatcagcaa gacccggtgc aacggctaac gctttgctca atacttcgtg ctggcctccg 2739121 gctgtcacac gaagatcatc aagaccggca tcgttttcgt gtgtggcgcc ggctacaatt 2739181 ctgccgttat caaacgacag aatgtactga tcactcggcg gcattacaac cggccacgat 2739241 cctgtatctg catctgtcat ttcaaaatgc ataatctgcg ctttttgaaa tgacacttga 2739301 aaatgaatgc caagaggctt caatatctca ttggcccatg ctcccgccgt cacaatgacc 2739361 gcgtcagccg caaactgctt tgtatctgtt tgcacgccgg tgactgttcc gttttcaaaa 2739421 agcaaggacg catttccttt gatgaccgtt gcgccgcgtt tctctgcagc gcttaaaagc 2739481 gaccggcaca gcgctcttcc gttcacacgg gcggcaccgc tgatatgaac cgattcatag 2739541 ccgtcagcta aaatcggaaa cagctttttc gtttcacttg cagacaagcg ggtaatgtcg 2739601 ccgatttccg gcgcatcctc ccgtctctta tacgcccttt cctccatttt atcgagttta 2739661 gacgcgtcag tatgaatgct gatggcaccg acacgtttgt atcctgtatc cgattcaccg 2739721 tctttttcca attgatggat taaatcctta tagtaccgcg ctcccccctt agcaagctgg 2739781 taccaatcct gattacggcg ctgcgagagc caaggacaga cgatccccgc cgccgcatca 2739841 gtcgcttgtc ccggctcttt ccgatcaatg acagtaacgc gagcgcctgt ttttgcgaga 2739901 tgataagccg tcgacgcgcc cagaatccct gcgccgacga tgatgtacga tttcatatgc 2739961 aaacaccttt tctattataa tgtctattca ttttaccaaa tcaaatgctt tccttcgacc 2740021 ttttgcccta atgtggaaaa accgcgaagt tcgtccaatc tctttactct cctatcgaat 2740081 atcctgtcac tatcaataga gaaaggatga taccatgagc gaaaatcgtc atgaaaatga 2740141 agaaaacaga cgcgatgcgg cagtggcaaa agtccaaaac agcggtaatg caaaagtcgt 2740201 ggtcagcgtg aacacagatc aggatcaggc acaggcgcag tcacaagacg gagaagacta 2740261 atgaacgaaa acatcattcc tcttaacaga catactcaag agatacccac tactgaatct 2740321 gttatcaaaa acagcggcaa ctcagaggtc catatcgaca ttcacattga tacaatgcca 2740381 attgcttttg ctatattatg ctctgcatta gccgcaaagc agatgacaaa agaggaattc 2740441 gatatggctt atactcaatt gcgagagatg aacagagaaa ataacagcag atcatctgta 2740501 aagcaaatta tcaatcaaga gacagaagaa gagtaaaaaa ccgcggcccc tcggccagcg 2740561 gtttttcttc tgcatacaaa aaggacgcga ctgaatcggt tacttctgta caatttgaat 2740621 aaggttaccg catgtatcgt cgaagacagc tattgtgact tcgcccattt ttgtcggttc 2740681 cgtcgtaaac gtcacgcctt tttcctttaa tcggttgtac tctttttgaa tatctgcaac 2740741 gccaaacatt gtggccggga ggccttcgga gaatatcttc ttttgatact ccttggcggc 2740801 aggatgttca ttcggttcga gtaaaagctc ggttccgtct tgatcatctg gagaaacaag 2740861 cgttatccac ctgaatttcc ccatgggaac gtcttccttt tttataaacc caagtttttc 2740921 tgtataaaac tccagtgcca tgtcttgatc ttgtacaaat atactggtaa caacgatttt 2740981 catactgttt ttccctcctt cgatatgaat gaagcatggt actatgctaa caatctggct 2741041 acaagcaaaa caacccacac atttatcaga ggccctgttc tgattttata aaattattct 2741101 atccatcctt tcagcaaatt tttaagcggt tcgttgttga atataagtac tcgatatttt 2741161 ccctttcgtt ttgatgttac gagtcctgca tcctccagta cagaaaggtg tttagctatc 2741221 gcctgtcgcg taatagaaag gtcgtacttt gtaataagac gtatcgtaag ttcatacaac 2741281 gtcagctcgt tgcgttcaga taattcgtct aatataagcc gccgagtcga atcgccgagt 2741341 gctttgaata tagcgtcttt gttcccattc atatattgag tataagcaac ccattagttg 2741401 catgtcaagt ataagcaact gtatggttgc gtgatataga aactgaacct atccggcgca 2741461 ggtctgaaat attctaatcg ataaggaatt aaaaccatta aaataacagt ggatatgtct 2741521 ctgaaaaata aaagaagacg aacttcaaaa gttcgtcttc tacaatcaaa ttcggcacgc 2741581 cggccatttt aaagttgata actatctcta aaccccttga taaacaaagg agttttcatc 2741641 attaaccgat agaaccttcc atttcgaact taatcaaacg gttcatttca actgcgtatt 2741701 ccatcggaag ctcttttgtg aatggctcga taaagcccat tacgatcatt tcagttgctt 2741761 cttcttcaga aataccgcgg ctcatcaagt agaagagctg ctcttcagat actttagaca 2741821 ctttcgcttc gtgctccaat gaaatgttat catttaagat ttcattgtaa ggaattgtgt 2741881 cagaagttga tttgttatcc ataatgagcg tatcacactc gatgttagag cgggcgcctt 2741941 ccgctttgcg tccgaagtgg acgattccgc ggtacgttac ttttccgccc tgttttgaaa 2742001 tcgattttga tacgattgta gatgatgtgt ttggtgcaag gtgaatcatt ttcgcacctg 2742061 catcctgatg ctggccttta cccgcaagag cgatagaaag cgtcataccg cgcgcgcctt 2742121 cgccttttag gatacaagcc ggatatttca ttgtcagctt agaaccgatg ttgccgtcga 2742181 tccattccat tgttgcgttt tcttcacaga ctgtacgctt tgttacaagg ttgtaaacgt 2742241 tgttcgccca gttttggatc gttgtataac ggcagtagcc gccttttttc acgatgatct 2742301 caacgaccgc actgtgaagt gagtttgttg tgtaaacagg cgcagtacag ccttcaacat 2742361 aatgaacgct tgcttcttcg tcaacaatga tcagtgtacg ttcgaactga cccatgttct 2742421 cagagttgat acggaagtaa gcttgtagcg gtgtttcaac cttcacgcct ttaggcacgt 2742481 agatgaaaga accgccggac caaacagctg agttaagcgc cgcaaacttg ttatcagtcg 2742541 gcgggattac ttttgcccag tgctcacgga aaatatcttc attctctttc agcgcgctgt 2742601 cagtgtcttt aaagacgatg ccttgtgctt caagatcttc tttcatgttg tggtatacaa 2742661 cctcagattc gtactgagca gaaacacccg caaggtattt ttgttcagct tcaggaatac 2742721 cgagcttgtc gaatgtttgt ttaatttctt caggaacttc atcccaagaa cgctctgaac 2742781 gctcagacgg ttttacgtag tacgtaattt cgtcaaagtt cagtgagttt aaatctccgc 2742841 cccattgagg catcggcata ttgtagaaat gctcaagtga tttcaagcgg aagtcaagca 2742901 tccattgagg ctcttctttc atgcgagaaa tttcttctac gatttctttt gtcaatccgc 2742961 gctctgaacg gaaaatggaa acgtccttgt cgtgaaaacc atacttgtat tcaccaatat 2743021 caggcatttt tttagccatc cattttcact ccaatccttt taattgccgc cttcttcttt 2743081 cgcgactcct ttttcaagtg ctttccatga cagggttgca catttgatac gggcagggaa 2743141 ttttgaaacg ccttgaaggg cttcaatatc cccgagatct atagaatcat catactcttt 2743201 cccttgcatc atatccgaga aaatcttaga catggaaagg gcagtttcaa tatctttccc 2743261 tttaatcgcc tgagtcatca tcgaagcgga tgccattgaa atggaacagc cttccccttc 2743321 aaacttcgca tcttccacga tgtctccgtc aagcttcatt gtcagtctga tgcggtcgcc 2743381 gcatgtcgga ttgttcatat ccacgacaat gctgtcattt aaaacccctt tatttcgcgg 2743441 gtttttgtaa tgatccataa tcacctgtct gtacaatgta tctaagtttg cattaaaaga 2743501 catttgtaaa atactccttt gtcttttgaa gagcttccac aagcttatca atctcttcct 2743561 ctgtattata cagataaaag cttgctcttg cagtagcagt tacatccagc catttcatca 2743621 gcggctgcgc acaatggtgg ccggctctga ctgcgattcc ctccgcatca agcacagtcg 2743681 ccacatcgtg cggatgaaca tcatcaaggt taaatgtgac aagcccggca cgctcttccg 2743741 gcccgtaaac cgttacgccg tcaagctggc ggaagcgttc aagcgcataa gctgcaagct 2743801 tgtgctcatg gcgggaaatc tcatcaagac cgatttcttc gagaaaatca atggcggcac 2743861 cgaggccgat tgctcctgca ataatcggcg tacccgcttc gaatttccac ggaagctctt 2743921 tccaagttga ttcataaagc ccgacaaagt cgatcatttc accgccgaat tcggcaggct 2743981 ccatgttttc cagcagggct ttctttccgt acagcacacc aacaccggta ggtccgcaca 2744041 ttttatggga agaaagcgca aagaagtcgc aatcgagatc ctgcacgtca attttcatgt 2744101 gaggcgtgct ttgtgcaccg tccaccacaa tgacagcccc attgtcatga gcgattttcg 2744161 ccatttcttt aatcgggttg accgtgccga gaacattaga tacatgagac accgcaacaa 2744221 tttttgtgtt gcttgtgacc gtttctctga cgtcttctaa agaaatcgtt ccgtcttcct 2744281 gcaacggaat atattttaat gtggcgccag ttgcttttac agcctgctgc cacggaatga 2744341 tattcgcatg atgctccatg taggtgatga ccacttcatc accaggtttc aggttggcgc 2744401 gcgcatagct taacgccacc atattcagtg atgtggtcgt gccttttgtg aaaataatct 2744461 cagccattga cttcgcgtta ataaacttgc ggactttttc acgcgctcct tcataaccat 2744521 ctgtcgctct ggttccaagt gtatggacgc cccggtgaac attggaattg tattggttat 2744581 aatacttatc cagtgtttca atgacagcac gcggcttctg ggaagtcgcc gcgctgtcga 2744641 gataaacgag atcatgtccg ttcacttgct gatgaaggat cgggaactgt tcacgaatat 2744701 ctgtgatatt cattacttca ctttcctttc gataacagaa actaattgtt tcttaacgcc 2744761 ttcaatcgga agttcattta ctaccggtgc aaggaatccg taaatgacta agcgttctgc 2744821 ttcttctttc ggaattccgc ggctcatcag gtagtaaagc tgaatagggt ccacacggcc 2744881 gacagatgcc gcatgtcctg cagttacatc gtcttcgtca attaaaagaa tagggtttgc 2744941 gtctccgcgt gctttttcgc taagcatcag cacgcgtgat tcttgctccg cattcgcttt 2745001 agaagcgcca tgttcgattt tgccgattcc gttaaagata gaagaagcgg aatccttcat 2745061 cacaccgtgc ttcaagatat agccttcaga agctttaccg aaatggatga tttgtgttgt 2745121 gaagttttct gtttgctctc ctcttccgac aacaaccgtt ttcgtatcgc cgtatgtgcc 2745181 gtcaccgtaa aggtttgttg tgttttcgga aatcgtgtcg ccatcgttca tcaggccgag 2745241 agcccactcg attttgctgt cgcgtccgcg cgcagcaccg cggcggttca cataagttgt 2745301 cacaccgctt gacagattat ccaccgcacc gtatgtcacg ctggcattat cacctgtgat 2745361 gacctcactg ataatattga agacagcgtc tttcgggttt acagtgctga tgtagttttc 2745421 tacatatgtt acagagctgt ggtcttcagc cacaatcagc acgtggttga atagagctgt 2745481 atcattgctt tcgtggacat aaacagcctg aaccggcgtc tccacctgaa catttttcgg 2745541 aacataaagg aatgctcctc cgttaacaag agccgcgtga agtgcagtta acttatgttc 2745601 gtcaaccttc acgccgtcct tcataaagta tttctccacc aagtcgctgt gctcgcgtgc 2745661 agcagtcaga atatcagtga agatgacgcc tttgtctttc aattcttgag aaagagaaag 2745721 atgtgccggc gtctggtcac gctgtacgta taatgtttta tcttcgtttt caatgtcgat 2745781 cagcgctttt acttcatcag tcaaatcttc taatgaagaa agcggttcgt tatccactgt 2745841 atgcttcgcg aaattcgtga agttccagtt tgtgattttt gttttgtcag gtttcggcat 2745901 cggcagatcc tcagcttgtt caagagcctg taagcgcagg ttcttcagcc aggcaggttc 2745961 ttggtgcttt tcggaaaagc ttttgagata ctcctgatct acggatagtt ttgtacctag 2746021 tgtcatatta atccccctaa cgcttacgct tcttggccaa cagtttcgtc ttcaatgcca 2746081 agttcttgtt tgatccagtc ataaccttct gcttcaagac gctgtgcaag ctctgcaccg 2746141 ccggatttta caacgcggcc ttgcatcata acgtgaacaa catccggagt gatgtagttt 2746201 aacaggcgct gatagtgagt gatcatcagg cagccgaagt tttcgctgcg cattttgttg 2746261 atcccttttg atacaacttt caaagcgtca atatcaaggc ctgagtcaat ttcatcaagg 2746321 atggcgattt tcggttcaat catcattaat tgaaggattt cgttgcgttt tttctccccg 2746381 cctgagaagc cttcgttaag atagcgctga gccatttcag ggtccatttc aaggaactcc 2746441 atgttttcgt ccattttgcg gatgaatttc atgagagaaa tttcatcgcc ttcttctctg 2746501 cgcgcgttga ttgctgagcg aaggaagtcg gcatttgtca caccgctgat ttcacttggg 2746561 tactgcattg caaggaataa gcctgcctgc gcacgctcgt ccacttccat ctccagtaca 2746621 tctttgccgt caagcgtgat gctgcctttt gttacttcat atttaggatg ccccataata 2746681 gcagctgata aagtggattt accagttccg ttcgggccca ttactgcgtg gaattctcca 2746741 ccttttattt caaggtttac accctttaag atctctttcc cttcgatttc aacgtgaaga 2746801 tctttgatcg ttaatgttga agcagccata tctatacctc caaaaatata taatcattat 2746861 tctcatttta ttctcattct aattttataa caaatgaaaa gtaaatacaa ctttttatcg 2746921 tgccttgcac attcctcaag tttaacaaag atcagcactt tattaaagcg attgaaaaag 2746981 aaaaagagtg gattcccacc cttttttaaa agattgattt tctcaataag ctcccgcaga 2747041 aatccgcttg cttttttcat aatcaagctc tctctgccgc tctactttca ttcttgtttc 2747101 cagccggcgt ccatattcct cgtatccaat tccgtgtgac agctgcatcg ctttttccat 2747161 ttctgacgta taatcgaggt tcagtctgtc ctggctgctg caaataatga atcaatccct 2747221 tcatatattt gctttttatt gtaccagtgc tgcgttggat gccgcaaaaa cgatttggcg 2747281 tgaaatagcg gcagatgaga cgaaagcatc ctttcagaac aaatgagaat ggtttttcgg 2747341 aatattcctt ctcttaatgc gtggtgtttc cgaattcctc aatgcactgt tgaacgactg 2747401 tcacgccttg gctgaaagct gcgccgcctc caaatgccgc tgccacactg acggcttcga 2747461 gaatgttttc ttctgacgct ccctgatcaa gacagccttt tgtatgatag atcatgcaat 2747521 attcgtcctg agcattgatg gcaattccga gggcgatcag ctgtttttct ctttcagtca 2747581 gagaattccc ggcaaagcac tgttcagtaa attcgttaaa ttttcttccc atcagcggca 2747641 tcttttgttc aaatgtgcct aaaccatgtt tatattgttt taacgcgtcc tgcatgcttc 2747701 ctctgtcttg attcaaagaa aatccctcca tctgtttaac attccttttt attatgaaca 2747761 gcttttagga aaatacgcga aaaaaacccc ggaattctca tccggggttt cagtcttatt 2747821 cagatacagg aagcacagct ccgtcgtatt ttttctcgat gaagtctttg atctttttag 2747881 agtgaagaac ttccatcagc gctttgattt ttgcagaatc ttcttcgcct tttcttactg 2747941 cgatgatgtt agcgtatggg ttgtttttcg ttgattctac ttcaattgcg tcttttttag 2748001 gatttaattt attttggatc gcatagttta cattgatgaa gaccgcgtct ccttctttgt 2748061 tttcatatgc ttttgccgtt aattcaggcg ctactttttt gaattcaagg tttttcgggt 2748121 ttttcttaat gtctttcaat gttgcgtcaa ctgtttccac tttagaatca agagtgatta 2748181 atccagcgtt ttcaagcatt gcaagcatac ggccttgttc agcaacgttg tttgtcagaa 2748241 tgattgtcgc accgtctgga aggtctttca gtgatttgta tgttttagag taaataccga 2748301 atggctctaa gtgaacagcg ccggcattca caagtttgta atctgtgttt tctttcattt 2748361 cttgctcaag gtaaggaatg tgctggaagt agttcgcgtc cacttcttta tcagctaaag 2748421 ctttattgta cattttgtaa tcactaagca ctttcacttt cagcgtatag cctttttctt 2748481 tcagcaatgg ttcagcttct tttaaaattt ccgcatgcgg tgtttttgtt gccgcaacga 2748541 caatttcttt cttgccggat tcagcgccgt tattcgaacc gcaggcagcc ataactcctg 2748601 caaatacaag cagtaatgca cccaaaaata gctttttcaa tgtaaatcct cccttatcgt 2748661 ttgtctataa tatttgttat tagatcaccg atgatttgaa taataaacac gatgattaaa 2748721 ataaacacag tagcaacgaa ggtaacatca gcgttattag actgatatcc ttctacgtac 2748781 gcaaggtttc caaggcctcc tgaaccaatg gctccggcaa ttgccgttga accgattaaa 2748841 gcgatggctg taaccgtaat gccagaaata agagcaggca ttgattccgg aatcagcact 2748901 ttgaaaataa tcgtagacgt tttcgcgccc attgatttag ctgcttcaat cacaccttta 2748961 tccacctcac gcagcgcgat ttcaacaagg cgcgcgtaaa atggtgccga gccgattacc 2749021 agcgccggca atgcggcgtt tggccctaag atcgtgccga ctaaaaattt cgtaaaacct 2749081 aatagtaaaa taattaaaat aaggaacgga atcgatctga atatgttaac aacggctgca 2749141 atcactgagt tgaccgcttt attctgccag aggcttcctt tgctcgtcag aaagagcagc 2749201 aagccgagga tgaccccgat gacaaaagca aacagtaaag aaatcagcgt catataaagt 2749261 gtttcatatg tcgcgttcca taattcagtt aaatcaacgt tcgggaagta tttttcaaac 2749321 attcgtgatc acctctgctt tcacctgttt gtcattaatg aatcggatca cgttttgcac 2749381 ttcttcctcg tccccgtcaa tgtggatgaa cagtgaaccg taagccccat ccttcgtctg 2749441 cgaaattttc ccttgcagaa tattgacgct gacattgaag tttctgatca tctctgtaat 2749501 cagaggctgt tcagctgact caccgacaaa tgtgagctga accatttttc ctgatgctgt 2749561 atcatcaaga aggtgctgaa gcgtctcttt cgtttcttcc ggctctgtca cctgttgaac 2749621 aaatcgtttt gtcatttgtt cctttggatt tttgaagaca tcgagaacct cgccttcttc 2749681 gaccaccttg ccgttttcca tgacggcgac tctgttgcag attttgcgta tgacatgcat 2749741 ttcgtgcgta atcagcacaa tcgtcaaacc gagtctttca ttaatatcgg acaatagatc 2749801 cagaattgaa tctgtcgttt gcggatctaa tgctgatgtc gcttcgtcac aaagaagaac 2749861 cttcggattg tttgcaagcg ctctggcaat tccgacacgc tgcttctgac cgccgctcag 2749921 ctgggacgga taagattttt cttttccttc taaacctacc agtttaatca gttcattggc 2749981 gcgcttgatc cgctcgctct ttttcacccc ggcaatttct aaaggaaaca tgatattatc 2750041 tctgacagtc cgcgaccaaa gcaaattgaa atgctggaaa atcatactga tctcatggcg 2750101 tgcttttctt aaaccgcgtc catttacttc attaatcttg gttcccgcca cttccacggt 2750161 tcctgaggtt ggtttctcaa ggccgttcag cagacggatt aaggaactct taccagctcc 2750221 gctatatcct ataattccaa aaatctcacc ttttttaatg gaaagcgaga cgttttggac 2750281 agcattgaca tctccatgtt tcgacttgta aacttttgaa acatcctgaa gattgatcaa 2750341 agcaatcacc tgccttaaca ctattctaag aaatcttccg gttttttctg caaaagaaaa 2750401 gcctttctgc acacttgagc agaaaggctt atataaaatg cctttctctc atctttcaaa 2750461 gctgaacgct tcgtgtgaat tggcaccatt tcaacagtgt tgatggttgc cgggcttcat 2750521 agggcacttc cctccacctc tcttgataag agaaatatat agtctttttc gtccggaaat 2750581 tcttaatgta gaatagcacg gcgaatgatt aaatgtcaat aaaataaatg atgtcaactt 2750641 ttactattat aataatttat tattttttaa ttttttaaaa tcctctgaaa aaatccattt 2750701 gtcagccaga gaatggcttc cagctttaac agggccctga atgacccctt tactttgagg 2750761 cttccgctct gaataaggtg ctgaagggaa atgtctccgt gcaataaatc aataatttcc 2750821 gtttggtttc cgtaaaaggt caggttggac gtttggggcg gagaaacttt tttcatttct 2750881 ccctgttcgt ttattgagac ggttaaggct tctgcttctc cttggaaggt aatgagcaat 2750941 gttgaggcat tcaaaagggg ttttaaaaac agatgctgat actcatcttc taaaacttcc 2751001 gctttctcca tatgtacaac ctcctatttg ttggtcatac atacacattt ctctctttgt 2751061 cgcaagaacc cctttataaa acgaacgaca atttcattgg atatgctgag aaatatgtca 2751121 taaatgggat gcggaagatg atttttgttt gatcagctca tataaataag aaacggaatg 2751181 aaatgcatat cctctttcga ccatctttcc gcctttaaac agcagaaaac aagggacgct 2751241 ttcaatttga tacgcttttg cgaatgtcgg agagtaattg acattgtttt gatagaaggc 2751301 gacatccggc agcatttctt tcaccactgt cagcattttg cttgcaagct ggcaggtgcc 2751361 gcaaaacgga gtatataaat atagaaggta cacatcatct tcaatgtgat caagttcgtg 2751421 ttcttggagt tctttcatgc tatacacctc gggactttct ttcaagaaaa atagtatgga 2751481 cattcagatt cgcacgcagc aatacagaag cgatatggtg cctgggcgca gccgctactt 2751541 ccttataggc tctgtcgaca tggagatggc aggcttcatt aaattcacgc ttcagctgtt 2751601 ttctcaattt ctcacctgat tcatcagcat caactaatat atagacgtct ttatcataaa 2751661 gctcgtcagc caattcctcg agcctcagct ggctgattgt tccgtttgtg cagataatgc 2751721 gcatcggttc attcaggacg ctttcgattt tctctttatc tgatttcccc tcgacaatca 2751781 taaccttttc cagctcatcc atcttcatct tgttcacctg ccgcgtcaaa tttgaaatgt 2751841 tcagattgta aaagaaggca gtgaaattca ccgccaacat taacaccagc cgttttcgta 2751901 gtcacaatct acatattttg cgtcgtctcc agagaccaca tcggctgtct tataaaattt 2751961 ctcattttca aaggaataac cggacttaag ctcatattca ttcatgcttg tcatttggcc 2752021 gatcatctca ttatcatgat ataacgagag ccggccattt tgaaagcggc ctgtcacgtc 2752081 attggtgaca tcgagctttt gtttgtcgaa agccatattg gacacctccc ataacgttag 2752141 cgtgtccaat tgcttttacg gctatcctgt tttagtcttc ttgtgtcatc tcttcgtatt 2752201 gctctgctgt catcagtttt tcaatttcag aagcgtcaga tggctcaacg acgatcatcc 2752261 atgctttttc gtacggagat tcgttgacga attccggact gtcatcaaga tcttcgttta 2752321 cttccacaac cgttccgtta atcggtgcat aaagctcaga taccgtttta acggattcaa 2752381 cactgccgaa tggctcgtcc gctttgattt cagcgcccac ttcaggaagt tcgacaaaca 2752441 cgatgtcgcc tagttcggac tgggcaaaat gcgtaattcc gattctggct ttttctcctt 2752501 caacttttac ccactcgtgt tctcctgagt aacgcaaatc ttttggtatg ctcaattgaa 2752561 tccctccatt ttttacagca ctacaataag aagataccac acttttcaaa aaaaatttac 2752621 attaagccca gttttcttca aattggtctt ctttaaatcc gacagtcact ttttcgccgt 2752681 ctgttgtaag cgggcgttta attagcatac catctgaagc cagcagttcg agctgttcgt 2752741 cctctgacat atgatacagc ttttccttga gattgagctc gcggtatttc atgccgctcg 2752801 tgttgaaaaa tttcttgaga tccagcccgc ttttttcata aagcgctttt aattcttctt 2752861 tgcttggcgg ctgctcagca atatgtattt cgtttatttc tttcccatgc tcttcaagcc 2752921 acttctttgc tttgcggcac gttccgcatt tagggtacca gtaaaaagtt aacgacatct 2752981 tcttccccct caataaaata atcgaggtta ttttaacaca gtttgtttta aaaacctaaa 2753041 acagtgcttc ttaaaaaaga gctccgcgca tgcggagctc atggccaatc agacagtata 2753101 tttctcagcc tcaaaaatgc ctgccgccgc ctcgcgtttt ttctgaatca cgtttttagg 2753161 cgttacgcgt gtcagcttgc gcagagcgga aagcatcatg cggagtgaat ctccttcttc 2753221 cattgcgata agggattcct ttgcatgcgc ttcgatttcg ttaaaggcct cttgaacgaa 2753281 aatttctgtg tacagcacct tttgcgctgc tttttcagcg ccttgtgcgg caatggcctt 2753341 ttccgttctg agcacggctg attccattgc gtatacattg ctgacgatat ccgctacgtt 2753401 cacgagaatt tcttgctcac gatcgatcgc ttttccgtat ttttgcgcgg ctaggccggc 2753461 agcaaacaac gcaatttttt tggcttgctt gacgatatat ttctcctgct ctaagacgcc 2753521 gcttccaggc tcttcaggca taagcatcat gagttcttcc tgcagcgact gcgctttttc 2753581 gaataaaggc agctcgcctt taagcgcttt tttcaggaag gtgcttggca cgattaaccg 2753641 gttgatttcg tttgtgcctt caaaaatccg attgatcctt gaatccctat aggccctttc 2753701 tacttcgtat tcctgcataa agccgtagcc tccatgaatc tgcacgcctt catcaacgat 2753761 ataatcaagc gtttcagagc cgaatacctt attcagagag cattcgatgg cgtattccgc 2753821 aatcgatttg gcgatttgcc ggccgtcctt gagatcttcg gccgtgaact ggctcatatt 2753881 gtcttcaaac agcccgacgg ttctgtatac agagctttcc atcgcataca gccttgaggc 2753941 cattgtcccg attttttcct gtgtcaatga aaaaccagca atcggcgttt taaattggcg 2754001 gcgctgattt gcgtatgccg cagacagctc gatgacgcgt ttagatgcgc cgattgtgcc 2754061 aaccgccagt ttgtaacggc cgatgtttaa aatattaaag gcgatgacat gccctttgcc 2754121 gatttctccg agcaggtttt cctttggcac ttcagcttga tccagaatga gggttcttgt 2754181 cgatgatccc ttgattccca ttttcttttc ttccggtccc gtggagacac ccgggaactc 2754241 tttttctaca ataaaggctg aaaacttgtc gccgtctacc ttagcgtaaa ctacaaatac 2754301 atcggcaaaa gcagagttgg taatccactg tttttcccct gttaatacat aatgggttcc 2754361 tgcttcattc agcacagctg ttgtttttgc tccaagtgca tcagacccag agccaggctc 2754421 agtcagagca taagcggcga tcttttcgcc tgaagcgagt ccaggcaaat attttttctt 2754481 ttgttcttct gacccgaaaa agacgatcgg caaggaaccg ataccgacat gcgcgccata 2754541 agaaagagaa aagcttcccg cacgcgaaaa tttctcagtg atgagtgccg agctgatttt 2754601 atcaaggccg agcccgccgt attcttccgg cacatcggcg ccaagcagcc ctagttcgcc 2754661 cgctttcttc aacagtctga cagaatgctc gaattgatgg ttttcgatat catctatatg 2754721 agggagaaca tcttgctcga tgtaatcctc tgttgttttc gcaatcattt tatgctcgtc 2754781 agtgaaatcc tccggtgtat acatttgatc gtatgtgaca tcctcgatta aaaatccgcc 2754841 gcctttttgt acgtcagccg ctttttttgc catttgtttt tcccccttta gcataattca 2754901 aatacaccgg ccgctcccat tccgccgccg atacacatgg tcacgactcc aaattgctcg 2754961 tttctccgtt tcatttcatg gatgagtgag agtgtaagct ttgtgcccgt acagccaagc 2755021 gggtgtccaa gcgcgattgc gcccccgttg acattcactt tttcttcatc aattcccaat 2755081 tccctgatta cttgaatggc ctgtgaggca aaagcttcat tcagttcaaa caagccgatg 2755141 tcctgcagct gaagtccggc aagcttcaaa gcgcgcggaa tcgcttccac cggtccgatt 2755201 cccatcactt ccggcggcac gccgcctacc gcaaaggagc ggaatttcac aagcggcgcc 2755261 aggccaagag catcggcttt ttcccggtcc atcagcatga cagccgccgc tccgtcactc 2755321 gtttgtgagg aattgcccgc agtcaccgtc ccgtcaacgg aaaaggccgg gcgcaatgtc 2755381 gataagatgt ctgcagtcgt ttgcgggcga acaccttcat cctgagaaaa cacaaactgt 2755441 ttttccatag gcttatggtc ttctccgatt tctgtcaccg tcacttcgac gggtacaatt 2755501 tcatctttaa attttccttc tgcaagggct ttagcggcgt tttgatggct gcgaacggca 2755561 aacgcgtctt gatcctcacg ggagacgccg tattttttcg cgacttgctc ggctgtgtgc 2755621 cccatgctca tataatattc cggtgccttt tctgccaaag caaggttcgg acgggtaaca 2755681 tgccccatca tcggaacttg cgacatggat tctgctccgc cggcgatcgc tgtatcgtag 2755741 gcgcccagca taattttttc tgctgcatac gcaatagact gaaggcctga agagcaatag 2755801 cggttaactg taatcgccgg aaccgtgtac ggcaggcccg cgagcgcacc gatatttctc 2755861 gccatattaa gcccctgctc cgcttcaggt gttgcacagc cgataatcaa gtcatcaata 2755921 ttgccttcgt agccgcctgc ccgtttcagc gtttctttta cacaaatcgc tcccaaatca 2755981 tccgggcgaa cggtggccaa cgatcctttt tttgcttttc caaccggtgt tcttgcacct 2756041 gacacaatga ctgcctcttt cataagctcc ctcctaattc cgtaaaggtt tacctttcac 2756101 aagcatatgc tgcattctcg cttgagattt tgcctctcct gacaaactca aaaacgcttc 2756161 tctttcgatc tccaataaat actcttcatc aacctctgta ccaaacggca cttttccgcc 2756221 cgcaatgaca taagcgagtt ttttcgcgat cttaaaatca tgctcagata tatagccgga 2756281 cagcttcatc tgctcagcgc caagcaagag tgccgcataa ccggtttctc ccggcacctt 2756341 gaccttttct tttacaggcg gccgccagcc ggtatcgtat aaagatgcgg ccagctgctt 2756401 cgcatcgtat aacaggtggt cttgattcac gctgatctga tccgtttctt ttaagatgtt 2756461 catctcacga gcctcttgag cggaagcgga cactttcgcc atcgcgattg tttcaaatgt 2756521 tttcattgcc gcattcatcg gatcatggcc gcggcgaaga tggttgatgt acagctcttt 2756581 gttacctcct ccgccaggga tgaggccgac accggattcc acaagtccca tataggcttc 2756641 gcttgccgct tgaatgcgcg ccgccggcag gcatgcttcc gttcctccgc cgagcgtcat 2756701 gccaaatggc gcggcgacga ccggtttcgc actgtatttg atcttcatca tcgtctcctg 2756761 aaaacggcgg atcacaaaat caacttccaa aaagttgtca tcttggactt ccattaagat 2756821 catggcgaga ttcgcgccga cgcagaaatt tttcccttga ttgccgatga caagcccctt 2756881 gtaattccgt tctgtttcct ctaatccttt gtggatcatt tgaatgatat cgaggccgat 2756941 cgcattgctt ttcgaatgaa attcaagaag ggccacatca tctccaaggt caattaagct 2757001 tgctccgctg tttttcgcaa tcacgccttt tgtttcttta agtgcttgta aatgaattcg 2757061 ttttttgttt tctttcacgg ctctgtattc gccgcggtca taataaaata ccgttccgtt 2757121 ctctttgatg tagaaggttt catttccttt gtccagcatc tcttttatcc agccaggcat 2757181 atctgctcca agctgctcaa gcttttccgc tgactgcttg aggccgatgg cgtcccacat 2757241 ctcaaaaggt cccagttccc agccgaatcc ccacttcatg gcttggtcaa tcgcatgaat 2757301 atcatcggca atctcgccaa gcagctcggc tgagtaaagc agggtttgag aagtgatatt 2757361 ccacagcaaa cggccggccc tgtcatccga ataaataagc gctttcattt tggcttttgt 2757421 cccttttgcc tgttttgccg cttcaagtgc cggtgatttc atttttgtcc gctcgccgta 2757481 agtaagcgtc actgggtcaa gctcataaat cgtttttcct tcttttttat aaaagccttg 2757541 gccggccttg cttccgatcc accctttttc cagcatatcg ttcatgaagc ttggaatgcg 2757601 aaacacttct ttttcatcgc catcagcttt gtcatacaca tttcgggcaa cgtgggcgaa 2757661 tgtatcgagg ccgaccacat caagcgttct aaaggtggcg cttttcggcc tgccgatcag 2757721 cggtcctgtg atcgaatcaa cctccccgac ctgataaccg cctttcagca tttcttggac 2757781 tgtcacgaga agcccgtaag tcccgatgcg gtttgcgata aagttcggtg tgtcctttgc 2757841 tgtaacaacg cctttcccga ggacattttc tccgaaagct gtcataaact ttaaaatatc 2757901 aggatccgtt tccttaatcg gaatgatctc tagcagcttt aaatatcgtg cgggattaaa 2757961 aaaatgcgtt ccaagaaaat gggctttaaa atcatccgac cggccttcag ccatttcctg 2758021 cactgatatg ccggatgtgt tgcttgagac gatgcttcca gtctttcgat gttcatccac 2758081 aagagcgaaa attttctttt tgacttcaag gttttcgaca acgacctcaa taatccaatc 2758141 tgcttctttc agtttttctg catcatcctc cagattgcca ggtgtaatat aggaggtatt 2758201 tttcgctgat gtgaggggag cgggcttttg tttcagcagt tttttcatcg cctgccggct 2758261 cagcctgctg cgcacctccg aactgtcctt cgtcagcccc tttttttcct cttcctttgt 2758321 caaatcgttc ggcacaatat ctagcagcag gacaggaatt ccgatgttag ccaaatgcgc 2758381 cgctatcccg gaacccatta cccccgatcc taaaacggct gccttccgaa tgtgtttgtg 2758441 catgagatat cccccttgaa cattgaatga atagtcattc attttttgac taaaaaaaat 2758501 gaaacccgtt tcttctttca tcttaaaaga tttccggttc gacttcaata gctaatttgt 2758561 tatttttttg tatgaagcct ataaaagtcg ggcaacttaa gcccggaggt gaagggaatg 2758621 gtacgagaga aaaaaaatcc gtcttcagcg gcagtcagcg cggcgagcgt aaagggagat 2758681 gccggtccga ctcagcatta cggcggcgga aaacggacaa gtcaaaatca gcagtataaa 2758741 aaacataaca tgggacaatc ataatgcagc tgcttcccac ggctgctttc actttttcaa 2758801 aattcctttt aacacaaacg ctgcattggc aggccgttcg gcaattcttc tcataaagta 2758861 gctgaaccag tccgttccat atgggacata cacacgcatt ctgtagcctt ccttggcgag 2758921 ttccttctga cgctccggcc tgatgccgta tagcatttga aactcaaatt gcgatgcggg 2758981 gatttgatgt tcggcgacga gctgtttcgt aaatgcaatg atgtcatcgt catgtgtggc 2759041 gacagccgtg tagttcccgc ttaacaactg cagctttatt aagctctgaa aatgaaggtc 2759101 cgtgcctctt ttgtcgggaa acgctacagc cgcagattct ttataagcgc cttttacaag 2759161 tctgagattc ggctttaagt cccgcatctt tctgatatct tctgccgccc ggtacaaata 2759221 cgcctgaatg accgtgccga gcttctcaaa ttcctgtttg cattgcctgt aaatagaaag 2759281 tgtctgttca taatgagaat agtcttccat atcaatggtc acagcaacat catattgctt 2759341 cgcaacggaa agaatggcgc gcaaatgagt aagagcaagt tcttctgaaa gatcgagccc 2759401 gattgaggtc agcttaagtg aaagctctga attcaattga tgttcggcaa tggcttgaat 2759461 ggctttcttg cattcctctg cgacttggtt tgcttctttt tccgaagctg catactcgcc 2759521 taaataatca attgttgcac acaaaccgga tctgtttagc cttttgacgg tcttaaccgc 2759581 cgattcaatc gtatcccctg cgacaaacct tcgtgctcca agccgcgttc cgtatgcttt 2759641 tgcgaacttg gtaagtgttt tattttgaga taagaataaa aacacatgtc tcaacatccg 2759701 actccctccc gccgtcatct tcaaaacacc tgtatataac tcccagtctg aaggaaacta 2759761 taaaatgaac agaaaccaaa ggaggatcac aatggataat cagcagcaat ctcaaatgcc 2759821 gccttccgtt atttcgacaa aggatcattt gtatctcaat gacatgctga actggaattt 2759881 gctcgcgatg aaaaaagcgc atttcatggc gcagcagtgc caggatcaaa cgttaaagca 2759941 agaactcgac cgcgtcggac acatgcatca tgatcactat caaagaatat taaagcacct 2760001 gcagccaggc cagcagcagt ccggctacat ccaataagga ggcgccagaa tgaatcagca 2760061 aaatcaaaaa atcagcaacc cgcagacacc tgtaccgaca acatcggaaa tgaatgacag 2760121 agatttcgtc aacgaattgc tgacaaccga aaaatacatg acaacagctt attgcactgc 2760181 cttgcacgaa ttcagccacg agtctcttta tcaggatatt caatccattt ttgatgagtc 2760241 acaaaaagcg caaagaaaac tatatgatct catgttccaa tatggatggt attctgttga 2760301 agcggaggat tcacaaaagc tgcagcagtc ctatcaaaaa ttccagcaga ccattcagca 2760361 gcagtctcct tatcagcaat aacaacatta gtaaaaagga tacgatgttc tttcgggcat 2760421 ctatcctttt tttgtgtaaa atcagttgac ttttcattta cgcttattta tatttaataa 2760481 gcattaacta ttttgtcatt aaaatatata tacagtgtat gtaacagagg ggaaatgaat 2760541 atgaagagtg cggatcagtt aatgtccgat attcaattat cgcttcaggc gctctttcaa 2760601 aagatacagc ctgaaatgct ggaaagcatg gagaaacaag gtgtcacccc agcgcagctg 2760661 tttgtgctgg ccagcctaaa gaaacacggc agcctcaaag tttctgaaat tgccgagcgt 2760721 atggaggtga agccaagcgc ggtgacgctg atggcagatc gccttgaaca aaaaaatctt 2760781 atcgccagaa cacacaacac aaaagacagg cgagtgattg atctcagtct tactgacgaa 2760841 ggagacataa agttcgagga ggttttggcg ggcagaaaag ccataatggc gcgctatctt 2760901 tcctttttga cggaggagga aatgctgcag gcggcgcata ttacagcaaa actcgcacaa 2760961 gcagcagaaa cggatgaaaa gcaaaacatg aaaagaggaa acggatgaaa atgagtaaag 2761021 aaggcaaaca atcaaaacga acgttattaa taacaggctt aattattgcc atgttttttt 2761081 cagcccttga cggtaccatt gtcggaacgg ccatgccgaa aattgtcggt gatctgggcg 2761141 gtttgagcat gatgacctgg ctgacaactg catatttgtt aacatcaaca accattgttc 2761201 caattgccgg taaactggct gatttattgg gacgccgcat tgtctatgta tcaggtttga 2761261 ttatttttat ggccgcttct gctttgtgcg gaatggccaa caacatgacg gaattgatta 2761321 tcttccgtgg actgcagggc atcggcggag gcatcatgat gccgatggcg atgattgtca 2761381 tcggtgactt gttcacagga aaacagcgtg ctaaattcca aggtgtcttt ggcgcaattt 2761441 acgggctggc ttcagtgatt gggccgcaaa tcggcggctg gattgtagac tcgttaaact 2761501 ggaaatgggt tttctatatt aacctgccag tcggaattat tgcggttatt tttattgcca 2761561 ggggattaca gggacgccag cagactggtc cgatcaactt cgatatcgct ggtattttca 2761621 caatgattgt cggtgtggtc agcctcctgc tcgccttaag ctttggcgga aaagattatg 2761681 catgggattc atggcagatt cttgggttgt tcgctctcgc actgatcggc attgtcagct 2761741 ttatcatcgt agaatcaaaa gcaaaagagc caatcctgcc aatgtattta tttaaaaaca 2761801 gaacatttac atttctaaac ttgatcggct tctttatgag tatcggtatg tttggcgcca 2761861 ttacgtttgt tcctttcttt atgcagggaa ttgtcggtgt aagtgcgtct gaatcgggta 2761921 caattatgac accgatgatg atttctatga ttatcacaag tatcatcggc ggacagcttg 2761981 tttataaaat tgggattaaa ccgcaaatca ttacaggcat gctggttatg gccggcggat 2762041 tcctgctgtt aacgacattg gatctcgaca cgagcaagct tgtcgctaca tcttttatgg 2762101 cgattattgg tctgggaatg ggtcttgtta tgccgattct gacattggct ttacaggaaa 2762161 gcttttcgaa ggaggagctt ggagttgtca cttcatccag ccaattcttc cgttctatcg 2762221 gcggaacatt cggcattacc atgctgggag ccgtaatgaa tgcgagatca ggaaatctat 2762281 taacagataa attggttcca tatttagact ctcttccggc acaggcaagc tcgtttgccg 2762341 cccagctaaa gggtatgatt gatacaaatc cgcaagggct gctgcaatca ctgttcagtc 2762401 cggacgcggt caaacaaatc cctgcggctt tctcatccca tattgtgccg attttaaaaa 2762461 catcgttgat ggattcgctc cacagcgtgt tttatacggg cctgatcttt atcgcagtcg 2762521 gagccgtatt caccttgttc ttaaaaccta tcaagctatc aaataagaaa gcggaagacc 2762581 aacaagaaaa agagaaggcg gcaaaagccg ttgaatcacc ttcccattaa tagagcaccc 2762641 cgcgggtatc aatccgcggg gttttttatt caatcatctg ggctcttcca tttccgaaag 2762701 accaatcctc atcctgattt ccggccagca tgataaacac atcttctttt cttacaccaa 2762761 gctcggaatg aatccggctc gcgattgagc ggtaaagtgc ttttttctgt tcagttgttc 2762821 ttgactgttt cagtgtaaaa tgaatgtata tcagttcatc agtacgctcg acttggagat 2762881 aaaatggatc ataaaaaaat tcgctttttt catattgtct gatgacttgg aaatagtcat 2762941 cttccggcac attgatttct tcaatcatcg attggtggat agtcctgctc agtttttgaa 2763001 gccacacttc gcttcttccc gaccgtaaat gaatctgtac aaatggcatc tccccgcatc 2763061 cctttcttta cagcgtctgt ccgctgtcaa ttgtgataat ttggcctgtg agtgattcct 2763121 gttcaattag tgaacaaatc aatttggcaa catcatctgg ttcagcaata cactgcagca 2763181 gcaaagagcc gatcatgctt ttcatttttt cttcccgtcc ggcccaccat ctcgttgcca 2763241 cagctcctgg tgctacaccg ctcactctga tttcaggcgc taaggcgtgg gccaatgatt 2763301 tcgttaaacc gtgcaccgct gattttgata ctgcgtaagg cattgatgag ccggcaccag 2763361 ttatccctgc gatgctgccg acgtttacga tcgccccgtc cttgcttttc ttcatgaacg 2763421 gaaccactgc ccgcgcgcag aaaaacatcc ctttcacatt gacggcatac agctcatcct 2763481 agacgtcttc tgtcgcagcc tcaagatcat ccattggaat atgccgtgta atgctggcat 2763541 tgttgactaa aatatcaacc gtgccgtgtg tgttcacgat tgcttgaatc atatcctgca 2763601 cgtcgctgtt tttggataca tctgcttgga tggcgaaggc ttgcccgcca gctttttgaa 2763661 tcatttccac tgtttcctcc gcttctgatt gcgagcgtga ataattcacc gccacaatcg 2763721 ccccacgctt tgccaattcc atactggctg cttttccgat tcctgtgccg ccccccgtta 2763781 cgagagctat tttgttcaag acattcattg ccgccactcc ttgctgttga ctaaagtata 2763841 tttctgattc cattgtaatc cagctttgat gttacgtata atgattgtta aagatactag 2763901 atatcactca gattgatagt aaacgaacgg aggagttcaa aatggaaagc ggagatttac 2763961 gtgtgtttca aatggtagct cgtgaaggga ccattacgaa agcagccctg cagcttggct 2764021 atgtacaatc gaatgtcacg gccagaattc aacaattgga agctgagctg ggtaccacac 2764081 tgtttttgcg ccataatcgg ggcatgacac tttctgcaag cggaaaattg ctgctggact 2764141 acgcaaataa aattataggc cttcttgatg aagcgtctaa agcgctctca tcctccgcag 2764201 aaccaagcgg gccgcttatg atcggctgca ctcagacaac cgccgcggta aggcttccaa 2764261 agcttctggc atcttattat gaagaacatc caaacgtcca gctgtcttta acaacaggac 2764321 atacgcaatt tctccttgat aaagttcttc gttatgaatt ggatggcgcg tttatcggat 2764381 gcgaatgcca tcatcctgag ctcgaatcct atcctgcgtt tgaggaagaa ccagtagttg 2764441 tttcggctgc ctccgtgccc gatgttgagg aagccatcac aaagccgatt ctcgtttaca 2764501 gcacaggctg ttcgtatcga gaaacacttg aaaaatggct gcgttccgtc ggtgtcacac 2764561 agccggtcat tatggaattt gggacgcttg aagcaattat cggcggggtt acagcaggtc 2764621 ttggcatctc gttgctgcca agaacggttg tgcagaaaca tgaagcagaa ggatcaattc 2764681 gattgtaccc gctgcctgaa gctctcagcc agatgaaaac agagtttatt gttcgaaaag 2764741 attcgtttat cagcagcgcg ctgagaacct ttatggattc ctttacgcca gttaaaacgg 2764801 ctgaatcaca aaaaagcagt ctgctataat gaacagactg ctttttggct attgtttgtt 2764861 tcgatgcgct tcatttaatt ccttaatatg ctgaatgatc tctttaatgc cctgcttcgc 2764921 gtcggggtat gtcgcattcc aatgcttagc gagcggaggc atgcttttgg ctatatgggt 2764981 gtacaaaatc cattgcttca cttcttcttt tagctcatcg tttgtttcac caagcagaag 2765041 ctcagtatac ttctccagca atccatcaag ctgctcctga agtttttgtt ccattttcca 2765101 tcttcctttc gaaaaaacag caaggagctt tctcaattga aagctccttc gctgcgttat 2765161 ttatccatgt gatgtgaaag ccgcttcctg gacaatgcat ctgcccctgc catgaggaat 2765221 gcaaagaggc gttccgaaga gcgggtcctg tgtaacctga cagttcatag aaaacacatt 2765281 ttgcacaaga tcacaagtga tgacctcttc cggacggcct tctgcataaa tccgtttatc 2765341 ttttatggcc acaagatgat gcgcatagcg gcacgccaag tttaagtcat ggagaaccat 2765401 aacaatcgtc cggtcttcct tttcattcag ctcaaacagc aaatcaagaa tttcaatttg 2765461 atgcgtcatg tctaaatacg tcgtcggctc gtcaagaagg atgatatccg tttcctgggc 2765521 aagcgtcatc gcgatccaag cccgctggcg ctgtccgcct gacaaagaat caacggcacg 2765581 gtcagccatg tcctcaagct ttgttgcttt aagcgctctt tcaactgctt cctcatcctc 2765641 ttttgaccac tgcttcagcc agttttggta aggatatctt ccttgcttca ccagctgatg 2765701 caccgtcagc ccctctggag ccgaaggacc ttggggcagg attgcgagct cttttgcgac 2765761 ttccttcgtc ggaagcttgg caatcgctct tccttccagc agcactgaac cgcctctcgg 2765821 cttcatcagg cgcgctaatg aacgtaaaag tgtcgatttt ccgcagccat tgctgccaat 2765881 aaatacggta atttcacctt tgggaattgt taaattcaac tcatcaataa taacggcatc 2765941 cccgtatcct aagctcagcg tttctgtaga aattgcactc atacccataa ccgctccttt 2766001 ttgctggctt tttagcagca ctatgtattg cacgttttct atatacatgc ttttaagtca 2766061 attgtcatca atgcaaatga ttccgatatt cagccatttg atatggtcat atatccctca 2766121 ttgtagcaga aaacactgac tttgaaaatc attttcaatt agttttatgg acataattga 2766181 cgtttatggg ttttttatca caagattact tcttgatttc tctgatggag ccgtccttca 2766241 gcttcaattt taaatcgata tgatcataat gactgtccag attaaatgct gccagcacac 2766301 tgtgtatcac ttctgtttca gccatttggt ctgtcacgga aagctcgctc aaaatcattt 2766361 tcatctcatc taacgcttct tctccttcct gattgacacc ggagagctta tcctgtattt 2766421 ccgctttttc ctgagtcccg ttctttgtat agattccttc ataacggtta tgctcaccat 2766481 ccccgtagct cacacgaagc gaaaaattac tgtagggaac ggacttcagc tgggtgacgg 2766541 ctgtattttc tccttctgcc tgatgctggt cttcattgaa acggcagccc gcaatcagaa 2766601 ccactgcgag acatacagcc ccggctgctc tgatcaaatg catatgtttc ccccctgtag 2766661 gattccattt attttaggta tatccagaga atgaaatcct cattcagaga agaattgaaa 2766721 aagccggggc atttaacgcc acggcttttt ctttaagatt cggtcatttg taaaaaggtt 2766781 tcggcgtcac gcacagccag cttgatggca ttctcccaga aatcgcgctt tgtgatgtca 2766841 gcgcccaaat gcttcatcgc caaatcctcc actgtcatag aagccgtatc gcgcaatagc 2766901 gccatatact tctcttcgaa tgtgtctttt tcttcaagcg ccaacgcgta aataccaaga 2766961 gaaaacaggt agccgaatgt ataagggaaa ttgtaaaacg gcaccctcgt gatgtgaaaa 2767021 tgaagctttg atgcccaaaa aagcggatga tattcttcta acgcattgca gtatgcctct 2767081 ctttgcgcct cttccatcag ctcattcaag cggctggccg gtaccactcc ccgctttcgt 2767141 tcctcgtaga atctcgtttc aaatagaaat cttgcgtgaa tgttcatgaa gaacgcaacg 2767201 cttctttgca ctttatcctc cagaagaaca agcttttctt ccctcgtctc ggcctgctgg 2767261 acagtcgcgt ccgccactat catctctgca aacgttgaag ctgtttctgc aacgttcatg 2767321 gcgtaggaac ggtttaacgg cctgacgttg agcattgctt cctgatggaa cgcgtgcccg 2767381 agttcatgcg caagggtaga gacatttgag gcgcttcccg aaaatgtcat gaaaatccgg 2767441 gattccccgc tgtccggaaa actggtgcaa aagccgccga ctctttttcc gctcctgtct 2767501 tccgcctcaa tccagccgtc ccgaaacgct ttttcagtga atgaggacag ctttttgcca 2767561 aacgttgaaa actggctggt aatgatattt gcggcttcat catacgaata gacctttccg 2767621 tcagaaccga tcggtgcctc gacatcgtac cagctgagtt tttcaaggcc gagcatggat 2767681 gctttccggt tcaaaaactg aacgaacggc ttcttgtttt cagtgatgac ctgccacatc 2767741 gtatcaagtg tttctttttt catcctgtta atttgcagcg gttccttcag gacattctcc 2767801 cagccgcgcg ctttataggt ttcaagccgg aatcccgcca aatgattcag cgtgctgctg 2767861 aaaatatctt gcttgctctc ccaagcttgg cggaaacgtt catatactgt ttttctgaca 2767921 gtacggtctt gatgatccat catattctcc gcctgaccga cagacaattg cttgttttca 2767981 ccgttttcct catacgggat cgtcattttc ccgacaacca tattgtataa gtcactccaa 2768041 gcgtgatatc cgtccaccgc aaggtttccg atcagttttt ccttaccggg gctaagcttt 2768101 tcggcaaccc tctgtcttct ttcatttaat atgtaagaaa catcgcgcaa tcccggtttt 2768161 gttaacaatt cattccacac gtcttgatta atgtccacaa gtttatgatc taatgtaacg 2768221 agcgacgatt gaaaatctgc ggaaagccga ttcatgaggc ctgatgctct atagcctttt 2768281 gatcattgat attctgggcc tggaggcaag caacaaaagc gccggcctgc tgaagcttga 2768341 cggatgtctg ttcgaataaa tcaagcaacg cggtcagccc ttcagcctct tcaggcgatt 2768401 caggcacctg aaacgcatca gtcctgtctt gaaatgcacg cagactttgt gacagcttct 2768461 caatataacc tttgaattct tccgattggc tcccgccctt aaaaaatgaa tcaagatccc 2768521 atctttggcc taccccttgc agcgccatat cacaaaaccc ctttccttct ttcgttctat 2768581 tatagaacaa ttctgaatta ttgtataaaa atttctatta caggcgtcat ttcgtgttca 2768641 ggatagtaca atagctgtag cagtttaata ggagggttag gatgaataaa aaaatagcca 2768701 tcgtgacagg agcgtccagc ggcttcggtc tgctggcagc tgtaaagctt gcccgatcat 2768761 ttttcgtgat agccacatca agacagcctg aaaaagcgga acagcttcga gaattggctg 2768821 cagcacacaa tgtgtctgat tctattcaca ttacagctct cgatgtcacc gatgaacaat 2768881 ctatagtctc attcggaaaa gctgttagtg cttacgcccc gatcgattta ctcgttaaca 2768941 acgccggaac ggcttatgga ggatttatcg aggatgtgcc gatggaacat ttcagacaac 2769001 aatttgaaac gaatgtcttc ggtgtgatcc atgtgacaaa aaccgtgctg ccttacataa 2769061 gaaagcatgg cggcgcaaag attataaacg tgagcagcat cagcggactg acaggattcc 2769121 cagcgctgtc gccatatgtt tcttccaagc atgcattgga aggtttttct gaaagcctgc 2769181 gtatcgagct gcttccgttc ggtatcgaaa ccgctttgat cgagccgggc tcatacaaga 2769241 catcgatctg gtcaacgtca ttatcaaatt ttatgtcggt gcctgctgac gattcagcct 2769301 atcatcaata ctataaaaag atcctttcct atgttcaaaa aaacggagaa gaaagcggag 2769361 atccccaaga ggttgccgac ctcatttatc aattggcaac aaaacagcac ataaagaatt 2769421 tgcgataccc gatcggaaag ggcatcaagc tcaccctgct gttccgatcg ctttttcctt 2769481 ggtctgcgtg ggagtctatc ctgaagaaaa agctattcag ctgatctaaa ttataattat 2769541 tataatttag tattgatttt tatttagtat atgatataat taagtcaaca gatcacaagg 2769601 aggacgttat cttatgaaaa ctgaaaacgc aaaaacaaat caaacattag ttgagaattc 2769661 actgaacaca caattatcaa actggtttct tttatactct aagctccacc gtttccattg 2769721 gtatgtgaaa gggcctcatt tctttacatt gcacgagaaa tttgaagaac tttatgacca 2769781 tgcggctgaa acagtggata ccatcgctga gcgcctgctg gcgattggcg gacagcctgt 2769841 tgccacagtg aaagaataca ctgagcatgc atctatcaca gacggcggaa acgaaacatc 2769901 agcatcagaa atggtacaag cattggtaaa cgactacaaa caaatcagca gcgaatctaa 2769961 attcgtgatc ggcctggctg aagaaaatca agacaatgcg acagcggact tgtttgtcgg 2770021 attaattgaa gaagttgaaa aacaagtgtg gatgctttcc tcttatttag ggtaacaaaa 2770081 aagctgaacc ttaatcgggt tcagcttttt gttttttctt agcttgaact gctttctgtc 2770141 tgcttggtca gtgttgcgtt caacgttttc gtttttccct ttcgcagcac ttggattgtt 2770201 gttttatctc cgacttttaa gtctttgtaa aggatctgac ggatatccgc actgctttcc 2770261 acgtctttac cgtttagttt gacaatgaca tcctcagatt taatacctgc tttttctgcc 2770321 ggcgaatttg cttgaacttc ttttacataa acacctttgc ccaattgatc tccaaacagg 2770381 ccgagcgtat tttcctgata ggtttcagga acttgtgaca tgtcaatcat ctgcacgcct 2770441 aaaaacggac ggtccacctt cccgttttgc agcagctggt caacaatcgg ctcgacatca 2770501 ttgcttggga tcgcaaatcc aagtgattcc acgccgcttt cgctcacctt caagctgttg 2770561 atgccgatga cctggccgct tgcattgatt aatgggcctc cgctgttccc cggattgatc 2770621 gctgcatcgg tttgcagcac gttcatttcc accgtcccct gtgttgtatc cacatcaatt 2770681 gtccggttca gtccgctaat gataccttgt gtcactgtac cggaaaactg ctgtccgagc 2770741 gggttaccga tagcgattac cttttcgcca gtgcgcagct gtgaagagtc accaaagctc 2770801 gccacttttt ttacattctt gccgctgatt tccaaaactg ccaaatcagt aatggtatcg 2770861 ctgccgacaa gcttggcagt ttccgtttct ccgttgtata gcgtaacagt cagcttgttc 2770921 gcgccttcaa cgacatggtt gtttgtaatg atatacgctt tatcgctgtc ttttttgaaa 2770981 ataacacctg acccggttcc gctttcactt tctgagctgg agcctcctcc cgtgccgaat 2771041 gtgttatttt gagaggtttg gatatttgag attccgacaa tcgtaggctc taaatcctct 2771101 accatatcag cgatgtttga tgcgttcgtt atcggcgccg ttgtaaaatt atcagactgc 2771161 acctgtttat ttgcggaagc ggtttcggtc gcctgatttt ggtctgacgg cagataaggc 2771221 gcgatgccaa gcatgaggcc cccgccgata ataccgccta aaatcgggct cagccatgcg 2771281 gctctccgtt tcttttcttt tttcacagcc gtttcttgct tttccatttc taaagcagaa 2771341 gccgtttcct gccgtcccgc ttcatacgac acaggcgcgt caagcaattc ttgttcagaa 2771401 tgtccaatca gcttctggtt ttctgtattc tgctgttctg tatgtgaagg ttcagtttga 2771461 tgttgatcgt tttggccatc acgtcgataa tccatgttct tacactcctt taacggttat 2771521 tcatttatcg ttacatattc atcgcatgta caagttcaat tgtcccaata atgaggagaa 2771581 aagcaaagca ccaaaataga atatgtttga tcatcctaca tcttcctcgc tctttttctc 2771641 ttcctttctt cccttaacca tatcataaac aaacattgtg ggataaaaat gaaaagaata 2771701 tgtgaaatta tgaaaattgc ctgccgtatg ttaaaactag tttataatga cgttgaaagg 2771761 atgtgaagag ccttgtcata caccatttat ctagttgaag atgaggataa cctgaatgaa 2771821 ctgctgacga agtatttaga gaatgagggc tggaacatta catcttttac gaaaggtgaa 2771881 gacgccagaa agaaaatgac accgtctccc cacctatgga ttctcgatat catgctgccg 2771941 gataccgacg gctatacatt aataaaagaa atcaaggcga aagatcctga cgtgccggtc 2772001 atttttattt ccgcccgaga tgcggatatt gacagagtgc ttggcttaga gcttggcagc 2772061 aatgactaca tttcaaagcc gtttttgccg cgggagctga ttatccgtgt gcaaaagctg 2772121 ctgcagctcg tatataagga agctcctcct gtccaaaaaa atgaaattgc cgtctcctcg 2772181 tatcgggtcg ctgaagacgc ccgcgaggtc tatgacgaaa acgggaatat catcaatttg 2772241 acgtcaaagg aatttgatct gctgctatta tttatccatc ataaagggca tccatactct 2772301 cgtgaggata tcctcctaaa agtgtgggga catgactact tcggaacaga ccgggtcgtt 2772361 gatgatctcg tccggagact gcgcagaaag atgcctgaat tgaaggtgga gacgatttac 2772421 ggtttcggct acaggatgat gtcatcatga aaaacaagcc gctcgcgttt cagatatggg 2772481 ttgtcatatc cggcatcctg ttagcgatat cgattttact gcttgtgtta ttttcaaaca 2772541 cgctgcgaga ttttttcact aatgaaacgt atacgacgat tgaaaatgag cagcatgttc 2772601 tgacagagta ccgcctgcca ggttcgattg aaaggcgcta ttacagcgag gaagcgacgg 2772661 cgccgacaac tgtccgctcc gtacagcacg tgctccttcc tgaaaatgaa gaggcttctt 2772721 cagacaagga tttaagcatt ctgtcatctt catttatcca caaggtgtac aagctggctg 2772781 ataagcagga agctaaaaag aaacgttaca gcgccgacgt caatggagag aaagtgtttt 2772841 ttgtcattaa aaagggactt tccgtcaatg gacaatcagc gatgatgctc tcttacgcgc 2772901 ttgattctta tcgggacgat ttggcctata ccttgttcaa acagcttctg tttattatag 2772961 ctgtcgtcat tttattaagc tggattccgg ctatttggct tgcaaagtat ttatcaaggc 2773021 ctcttgtatc atttgaaaaa cacgtcaaac ggatttctga acaggattgg gatgacccag 2773081 taaaagtgga ccggaaagat gaaatcggca aattgggcca taccatcgaa gagatgcgcc 2773141 aaaagcttgt gcaaaaggat gaaacagaaa gaactctatt gcaaaatatc tctcatgatt 2773201 taaaaacgcc ggtcatggtc atcagaggct atacacaatc aattaaagac gggatttttc 2773261 ctaaaggaga ccttgaaaac actgtagatg ttattgaatg cgaagctctt aagctggaga 2773321 aaaaaataaa ggatttatta tatttaacga agctggatta tttagcgaag caaaaagtgc 2773381 agcacgacat gttcagtatt gtggaagtga cagaagaagt catcgaacga ttgaagtggg 2773441 cgcggaaaga actatcgtgg gaaattgatg tagaagagga tattttgatg ccgggcgatc 2773501 cggagcaatg gaacaaactc ctcgaaaaca ttttggaaaa tcaaatccgc tatgctgaga 2773561 caaaaataga aatcagcatg aaacaagatg atcgaaatat cgtgatcacc attaaaaatg 2773621 acggtccgca tattgaagat gagatgctct ccagcctcta tgagcctttt aataaaggga 2773681 agaaaggcga attcggcatt ggtctaagca tcgtaaaacg aattttaact cttcataagg 2773741 catctatctc aattgaaaat gacaaaacgg gtgtaacata ccgcatagca gtgccaaaat 2773801 agactgtaga tgttttgcag tctatttttt tatgtgaaag aatagccgtt aaaatctctg 2773861 taatttgttt tgagcggctg tttgcattga tgaacccatt ttttctctga caaggtctgc 2773921 ttcggatatt tgactttctc cactttgatt cctctgtttc gcaagcggct gatcatttcg 2773981 tccaattctc tcattctaga ttcacccttt cgcttgagct ttgaccattc ggtcatctca 2774041 atttataata taaataatac atgataaaaa aacaagttac aataaggtta attttataac 2774101 agacggtgtg actatatggt catatcctag caggcctccg ggctccgaaa gggtggaacc 2774161 attgaaggaa aaagaaaaac tgattattga aacagcctta aaactatttg cccaaaaagg 2774221 atacaactca acatcagtcc aggaaatcgc aaaagaatgc aaaatatcta aaggcgcttt 2774281 ttatatttat tttccttcga aagaagcgct tcttctctct atgctgaact actattatga 2774341 taaaacgttt acccgaattt taaatattaa aacgaagggc gacagcccca gaacggctta 2774401 ccgtaaacag ctgaccgtcc tctatgaaaa cattcttgaa cacaaagatt ttatcagcat 2774461 gcagttgaag gagggttctc tgccttacac agaagaagtg gagcaatgcg caaaaaaaat 2774521 ccgccagtcc tcacttcaat ttcatatcga cagcctgctg aacatctatg gaaaaaaagc 2774581 ggaaccgtac actgctgagc tttgtttttt aatagagggc atcagccaga tttacctgga 2774641 atgcatgatt ttgctcgggt acactgtgaa gccgtctcaa ttagctgata tcattatgaa 2774701 tcgaattgat gatatggtaa aaggcatgtc tgaacgaaac gataagcctt tcatcacatt 2774761 ggaagaggcg agctctttat tcggacctct tacgcacgga cggcctgacc cgctgactga 2774821 atcaattgtg aaaagcctac gtgacaaaat taacagctta aacacaaact cctctcttga 2774881 attatcggag agcttggaca tacttgaagc agaaatgaag aaaaaaacac cgaagctggc 2774941 gatcataaaa ggaatgattc ataatctgac ggagtctgaa gctctcgcca aagatgcgga 2775001 acagcttaaa tatttattaa aacagcaaca tatttagaag aacggctgct taaaaagcag 2775061 ccgttcttcc tattacgcct ttggttttac catgtcttcc ggcttaacca tttcgttaaa 2775121 ttgctcctct gtcagcaatt caagcttcaa agctgcttct ttgagcgtca atccctcttt 2775181 atgggcaagc ttggcgattt tcgccgcgtt ttcataaccg atatgcgggt tcagcgccgt 2775241 aacaagcatt aatgaatttg acaggttttc ctgaatggtt tctttattag gctcaatacc 2775301 gacagcacat ttatcatgga atgaattcat gccgtcactg agcagctgca cagattgcag 2775361 gaagttgtaa ataataacag gcttaaacac gttcagttca aagttcccct gactcgccgc 2775421 aaagccgatt gtcgcatcgt tccccatgat ttgcgctgcg atcattgtta acgcttcgct 2775481 ttgtgtcgga ttgactttac caggcataat agagcttccc ggctcatttt caggaatgac 2775541 gatctccccg atgccgcagc ggggtccgct tgcgagccat ctgacatcgt tcgcgatttt 2775601 cattaagtca gccgcaagcg cttttaatgc gccatgcgca taagtgattt cgtcatggct 2775661 tgtcagcgcg tggaatttat tcggcgagct gctgaacgtt tggccggtca gcttagtgat 2775721 ctcttctgag acaagctctc caaactctgg gtgggcgttg atacccgttc cgacagccgt 2775781 tccaccaatt gcaagcgcac gcattttatc tgtcgcttcc aaaatcattt ccttcgaacg 2775841 gtccagcatg tgaacccatc cgctgatttc ctgtccgagg gtcagtggcg tagcatcctg 2775901 aagatgcgtg cgtccgattt tgacaatatc attgtatgct tttgcttttt catccagtgt 2775961 attgcgaagc tgatcaagcg ccggcacaag ctgctcgtaa acagccaaaa cagcggcaac 2776021 atgcatcgca gtcgggaatg tgtcgtttga gctttggctt cggttcacgt catcatttgg 2776081 atgaatcgtt tgatcagagt tcttctcttt taataaagca gtcgcacggt tggctaccac 2776141 ttcgttcatg ttcatattgc tttgtgtgcc gcttccggtc tgccatacga caagcgggaa 2776201 gttgtcatcg tacttgcctt tgagcacatc atcacaaacc gctgcaatcg cttctgcttt 2776261 ttcagcgtcc agattgccga ggcgtttatt agctagagca gtgcttcgtt ttaaaattgc 2776321 aaacgccttc acaacacgca tcggcatttt ttcagaaccg atcttaaagt tctccttgct 2776381 tcgctgtgtt tgggcgcccc aaaatttatc agcaggaact tttacttctc ccatggtgtc 2776441 tcgttcaatt ctgtattcca tttatgtatc cctccataac ggttgcttca atagatcata 2776501 attcgccaat gacacaaaaa atccttttta tttttcgatc ttggcagatt ttaattttaa 2776561 ttcaagatat acgcgggaat cctttgaata tttgtatttt ggatttgtcc tgccgtactc 2776621 ctttgatgta taagagacat cataatgctg ttcaaatgat ctaatgagct gttcaatttc 2776681 ttcttgtttt ccagctagcc ttacctgtgc cacttcgtat cctccgcttt cataaaaaaa 2776741 cttactccat gaaatactct aacacagtat atcatttttt taacaggaaa agataacctc 2776801 tactaaggtt ttggataaga ggtgacctca ttggaacaaa cagagtttaa ggaatatata 2776861 cacgataatt tagcattggt gctgccaaaa ttaaaagaaa acgatgatct ggtgaaaaac 2776921 aaaaaaatgc ttgcgaacgg actggttttt tactatctct atttcagtga aatgactgat 2776981 gagaataagg tgtcagaagc cattaaaact ttgattaaag atgaggagac cttaacgctt 2777041 gaccaggtca aaaaacgcct tgaccagctt gacgcaagac ctgttgaaac tgcaaaaaaa 2777101 acgattgaat cgattctcaa cggcaattgt gctgtgttta tcaacggatt ggataaagcc 2777161 tatattctga ccacaggaaa gaaaaaaaca agaagcctga cagagccgac aactgaaaaa 2777221 gtggttcgcg gcccaaaagt agcgtttgta gaggatattg atacaaatct cgctctgatc 2777281 agacaaagaa cctctcatcc gaaattgatc accaaaaaaa tcatgatcgg cgaaaacaag 2777341 ctgaagcctg cagccattat gtacattgaa ggcaaagcaa aaaagtccgt cataaaagaa 2777401 gtgaaggcgc ggcttaaaaa tatccagctg gaagatatcc aggacagcgg aacgctcgag 2777461 gagctcattg aagataataa atattcacca tttccgcaga tacaaaatac ggaaagacct 2777521 gacaaagtat cttcagccct gtttaacggc cgtgtggcaa ttttggtcga cagttcacca 2777581 tttgtgctgc tggtgccggt ttctctcggc atcctgatgc aatccccgga tgactactat 2777641 gaacgctgga tttcagcatc tcttatccgg tcgctgcgct ttgcttctat ctttatcacc 2777701 ttgtttttgt catcgattta tataacactt gtttccttcc atcaggggct gctgccgacc 2777761 gcactcgccg tcacgatttc ggcgaacagg gaaaacgtgc cgttccctcc gatatttgaa 2777821 gccctgctga tggaagtcac catcgagctg ctaagggaag ccggactgcg actccccaat 2777881 ccgctcggac agacgatcgg cctcgttggg ggcgtagtca tcggacaggc tgctgtagaa 2777941 gcgaatctcg tcagttcgat tttggtcatt gtcgtcagtg tcattgccct ggcatccttt 2778001 accgttcctc aatacggaat gggtctgtct ttccgggtgc tgcgttttat ttcgatgttt 2778061 tccgccgcta ttttagggct atacggcatt attttattta tgcttgtcgt ttatacgcac 2778121 ttaacgagac aaacgagctt tgggtctccg tatttttcgc caaacggatt ctttagcctg 2778181 aaaaatacgg atgactccat tatccgtctc ccaattaaaa acaaaccaaa agaggtgaat 2778241 aatccaaatg agccaaaaac agactccact gaaacttaat acctttcaag gtatttctat 2778301 tgttgcaaat acaatgcttg gggccggact tttaacattg ccgcgagcgc tgaccactaa 2778361 ggctaatacg cctgacggct ggatcacgct gatattagaa ggtttcattt ttattttctt 2778421 catttattta aacacgctca ttcagaaaaa acatcaatac ccttcactct ttgaatattt 2778481 gaaggaaggg cttgggaaat ggatcggcag catcatcggc cttttgatct gcggctattt 2778541 cctcggcgta gccagcttcg agacacgggc aatggctgaa atggtgaagt ttttcctgct 2778601 ggagagaacc ccaattcaag tcattatttt aacgtttatt tgctgcggca tttatttaat 2778661 ggttgggggc ttaagcgatg tgtcgcggct gtttcccttt tatttaacgg taaccattat 2778721 tattttgctg attgtgttcg ggatcagttt taaaattttt gatatcaata atttgcgtcc 2778781 tgttttaggc gaaggccttg gacccattgc aaactccctt accgtcgttt ccatctcttt 2778841 tttaggaatg gaagtgatgc tgtttcttcc tgaacatatg aagaaaaaga aatacacgtt 2778901 cagatatgcg tctctaggat ttctgattcc gattatctta tatatcctta cgtatattat 2778961 cgttgtcgga gctttgaccg ctcccgaggt gaaaacgctg atttggccga ctatttctct 2779021 ctttcagtcc tttgagctta aaggcatatt tattgaacgg tttgaatcct ttttactggt 2779081 ggtctggatt atccagtttt tcaccacatt tgtcatttac ggatactttg ccgctaacgg 2779141 gctaaagaag acatttggat tatcgactaa aacaagcatg gtgattatcg gcataacggt 2779201 cttttatttt tctctctggc cggatgacgc caatcaagtc atgatgtata gcgattatct 2779261 tggctatatt tttgtctccc tgtttctgct tccgttcatt ctctttttca ttgtagctct 2779321 caagaggagg attacaacaa aatgaaaatc cggattttat gtatgtttat atgcacccta 2779381 ttgctgtccg gatgctggga cagtgagaat atcgaggaat taagcttagt gatcggaata 2779441 gggctagaca agcctgacga tgaaaattta gagctgacac agcaaattct cgtgccgaaa 2779501 ataatcagcg ccaaggaggg ctcttcatct gatccgacac agctttctat cacaaagggt 2779561 aaaactgtcc atcaaatgat gagaacctct gcattaaagc ataagcctac gttttcacag 2779621 catttgcgtc tcattctgct ttccaaaagc gtgattgcgg atcaaattgg aatggacgcc 2779681 attattaacc agtttgtcag agacaacgga acaaggagga gttcctacgt ctttatcacc 2779741 aacggccgaa ctaaggatat atttaacatg aatgatgaag gcgaacccgc atccaacgtg 2779801 atatatgatc tgacagagaa taataaggtg acgatcagaa cgatggagcc agttacattg 2779861 ggggagatct cagaacactt aacctctgac gattcattcc tcatccctca tgtcggtaag 2779921 gaaaacggca agctcgcgat aaacggagcc tctatcataa aaaataaatt atggcaccgg 2779981 gacctcaccc cgattgaggt tcaaaatatc agcttatttt caggcactgt cgagggaggc 2780041 gtcattgact tgaagcgcga tggccatctc ttttcttatg aagtatattc aagcaatcgg 2780101 aagatcaaga cggcatacaa ggacggaaag ttcaaattca ccgttacccg caatattgaa 2780161 ggtcgtctat ctgaggactg gaatcccaat gaagactcgt ttaaggattc atatattaaa 2780221 agtattgaaa agacagtcga aaaacgagta cacgaaacag taacgtcatt tattacagag 2780281 aagctgcaga aagagatcaa agcggacgta accgggctgg gaaacgaggt cagaattcat 2780341 tatcctcaaa agtggaaaaa gatttcaaga aaatgggatg atgattattt cagcaatgcg 2780401 gaaatagact accgggtcaa tgtgattgtc agagacttcg gaacgaaagg cgcaaacaaa 2780461 tagcagccgc ctaattcacg agatgatttc ggtgtgcgta caccgccgcc tgcgtccggt 2780521 cactgacatc cagctttgat aaaatattcg taatatgtgt tttgactgtt ttaatcgtaa 2780581 taaacagttc ctcgcctatt tctttgtttg tctttccttc tgcgatcagg cagagtattt 2780641 cgagctcccg ttttgtaagc gattcatgcg ggagcgcgtt ttcacctgag tggcgcagcc 2780701 tggataatac ttttcccgcc acttttgact ccagcttcgg ctctcccttg cttgcggcgc 2780761 ggatggcatc ggcgatttct gccgcttttg aggttttcaa cagatagctg agcgcgccag 2780821 cttcaataac cgggtacact ttgtcatcat caatgaagct agtgagcaca ataattttcg 2780881 ggtcggaaag ctcccggcaa atttgctttg tagcttcaat gccatccatg ccctccatga 2780941 caaggtccat taaaatgaca tcaggcgaca gttccacagc aagccgaaca ccttcgctgc 2781001 cgtccgatgc ttcgccgatg acttcaatat cgggctgcgc ctccaaaaaa gccgcgagcc 2781061 ccattctgac catttcatga tcatcaatca ataatactcg aatcacgttc gttctctcct 2781121 ttttcttccg gaaaaatcgg gaccttcact tcgatttgag tgccttttcc ttctactgaa 2781181 atcacttcgg cgacaccgcc gatttcactt gcacgttctt tcatagaatt caagccgtat 2781241 gaggaggctt tcacctggtc cattttaaag ccttttccat tatcaatcac cttcagacgg 2781301 agctggctgt tctttatgcc cagaatcacg gttacttttg acgcttttga atgtctaaat 2781361 acgtttgaaa gggcctcctg cacgattctg aacaagtggt cttcaacacc cttggatatc 2781421 gctgtgtcct gtatatccca ctcaatatca atcggctgct tttttcggaa ctcgtccaaa 2781481 agctccgtaa ggccctcctt cagccctttt ccttcaaggg taacaggccg taaatggagc 2781541 agcagcgccc tcatctcatt ttgggcttcg cctgccatat gctcgaccat cctgatccgc 2781601 ttgactgttt tgtcatcagc atccttgaca tgttccagca cggctgatgt catcatcgat 2781661 atggcaaaga gctgctggct gaccgcatca tgaagatctc tggccaatcg ctggcgttct 2781721 tctgagataa ccgacttctt catttgagcc tgccattccg cacgttcatt ggaaagtttc 2781781 tggagggatg cgacttgaag ctccacgcgc ttcgccattt cgttcagctg atcagcagcc 2781841 aggccgattt catcatcacc gagcggcggt atccgataag cgaaattgcc gttttcaaag 2781901 gttaaaatgg attcaattaa tgtatcaatc cttgtcttca accggttgcc gtacatatac 2781961 cctgaggcga aaccgacggt cacgctgatc agaagcaaaa tcaggataaa cggaattccg 2782021 aaccagcttg atgacagcaa aacaagcgga tcgagccgat agtaaaacat cataaaggaa 2782081 atcaggcaaa caaaaaggag caggctgatt cccgttgtca tgcggatggc gcgccattgg 2782141 aggctggcaa gcattttttt tctcatacgt acttcacatc cacatcaccg ataaataagg 2782201 aaacggacac ttttacccgg cgctttgact cgctaaaatc agttgacgcg gcatatacct 2782261 tcgtgcttaa tccgcttttc ttcgagccga tcagattaat gtctcctata aaaacagccg 2782321 agctgacagc cacttcaagg tccgatggta cataaatatc aacgttacca atgactccgc 2782381 taatgacgat tgtactttct ccctcgggaa tcatcgcttt agataaatcg attttgatat 2782441 caccgataaa accagagaca tttaaatcgt tcaggtcaaa cggctgcttc atcatttgca 2782501 gctcaccgat aaaaaagctg cgcatgtcgg gatgttttac atcttttggc ggctcatgat 2782561 gttctttttt attgagattg acctgtttct cattcggttc aaatatcggc ttccctttga 2782621 taagcctgta gccggcgtaa atcagaaatg cggcaaacgc atagccgaat aaattaaagg 2782681 tgatgctgaa gaggtttttc aaaaatagaa acgcggcaaa gatatacatg acggagccaa 2782741 gccaatcacg ggaatatttt ttaaggaaat agccggcaat cagaaaaaag agcggccaaa 2782801 acagcagatc gcctattccg ataatttgca aaaacatact gatgccgaat aaagcaatga 2782861 tcaatccgag aagctgtttt tttgtcattc ctggtgtccg cctcctttct tctgcctagt 2782921 gctaccgtat cgctagatcc ccgctgtccg ttttgatgtc gattggatgc cggccgcttc 2782981 cttgcgtgcc tgtgatgtga tgctgttctt tatgtccttt atcagcaaat gaatacggcg 2783041 aactgacgtc accgcttgct gataaagcat tgactgcaaa gctgccattt tggggaaggc 2783101 ttacattagc atcaccgctt gtcagcgtga cagatacggg accggttacc tttttcaata 2783161 cagcattaaa atctcctgaa gtcattttca catcaagaga gcctgataca tgaaccagat 2783221 ttgcgtcccc tgaagctaaa tcaatgccgg ctgttttgga gacggtattt gaaatggaaa 2783281 catcccccga tgatgccttc actttcagat cttgaatgcg gacgtccgtc acgctcgtat 2783341 ttccgctcgc agatactgcg ttcagcccgg aaagcgcaag atggtcattc ccggccacag 2783401 acacgtcacc gcttgaggtt cgtactgcca gatcaccttt ataatcatac ggaagcctga 2783461 cgataagagt tgaacggtta aatccattca aaaattgaaa ttctttttcc tttacggtca 2783521 gctccagttt tcttttgttt tcagtaacaa ataactttcc tgagtctcct gaaatgcctg 2783581 ccgatatgtc acttcgttct tccgctataa tccggacatc cttgctatcc gactcaatga 2783641 ccatgctgtc aatgtcccgc ggcgatgcgc tggctgaatc agcttctgtg ccatttatga 2783701 aacctaggcc tgcagcaaac acatctttta cgacgacggc gaaaaaaacc agaataccgg 2783761 cagtgatcaa cagtttgcca agcatttttt tcattcggtt tcatccttct cattcattct 2783821 attataaagg aaaagcttgc gaattgatac gtgcggaagg gaaggacttg accgcaaatc 2783881 cttccccgtt ccgcttattc atttgccgct tttgtctggt ctgatttttg cagtgaaagt 2783941 gtccgcattt tttcaatctc cgcttccaca tcgtctgcga attctttacg tgtaagttct 2784001 gtgccggctt ccgctgactt tgaataattc gcgcggattt ccatttcttc aatacgattt 2784061 tcaatacgta aaaattcacg atacgcgctt tcactgtcaa ttttgtcaaa tgtcgtattc 2784121 atatgctctt tagctttcgc cgcatttgcc cgcgcaatca gcgcctgttt tttatccttt 2784181 acgtcctgaa gctttgtttc aagtgcagcc agctgctctt tcagatcagc cagctgactg 2784241 tttgcctgtt cataggaagc tttatgctca gccgccttcc cttctaaata cttcatttca 2784301 gtcagcgcct ttttcgccag ttcttcttca cctgcgtcaa atgcgagctg tgcctgattt 2784361 ttccgtttgc cagccacttc agcggcttct tcatattttt tcttaaattg ataggcaatc 2784421 gtgtgctgtt tcacaattgt ttgctttgct tttgcgatgt cgctttccat atcgcgtaca 2784481 tattgattca gcatcacctt tggattctcc attttatcaa gtccttcatg aactgacgca 2784541 acaaacatgt ctctgattct ttttaatacc atacctgatt cctcctaata tattgatatt 2784601 attttttctt caaaaattct tcccattcgt catcaaagtg agattggtag gcagcagaag 2784661 ccggttcagg atcaaaagat gatacaccgt tatcagctga tccgtttttc atcagcttcc 2784721 agccgtaata caccatagcg gccgccaatg cgattccgac gacaaacgga agtgagcaga 2784781 tgagcataat ggctccgata ccgcccacga tgattcccgt gatggttttt cccgcggcaa 2784841 accttttgat tcctgcgtat gtcatcaagc tcccgatggc gagcgggatg ataaagccga 2784901 agcttcctcc tccaaaaaag acggagatcc caaatacaat taataagaat ccgcctattg 2784961 ttttcttgtt tattttcatg cagatcctcc tttcgttttc cttgtcttca tcttatacaa 2785021 gttggaagat atgcaaaacg aatcagagat tgatttttat ataagaccgg agtcgtatct 2785081 cgcaccggac ccattggcac aaaaaaacgc catgcacgag gcatggcgtt ttaaaaccct 2785141 ttacagatga acacttgctt ccctttcttt aattaggtcg gacctttctg ctttggccaa 2785201 ttttgtaaac agcaagattc cgatacccgc aataatttcg acaatcccac cgacagcgat 2785261 cactttacct gagccgaaag cattagcggc atacccgcaa atgacagctc cggcagggat 2785321 cgaaatattt gagatcatat gtataacggc gtaaacctgc ggctgatcct cactatccac 2785381 agacgtctgg ataatcgtgt actcaggaac attaacagca ctgactgcgg caccaaaggt 2785441 aaaagcagcg aaaaagacga gcggcaaaaa ggtattcatc ccggtaataa agaaagcaaa 2785501 tccttcaata atgccggcag tgacgaataa caagccgtac ctgtttacct tgactttcgc 2785561 cagcacaaac cctaataaaa acgcgcccgc ggcggtggtg gcctttaaaa gcgagtatac 2785621 gatcggctgg ccgtttaaat cttccgcaac gtatacggca gagagcgctt cccatggggc 2785681 agccgcgaaa ttcataaaga tacagtaaat ggcgagcgga tataaaatct ggtgttttct 2785741 gacgagccta aagccgcgtt tcagtcttcc gatatatgtg cctctctgtg taacaaccgc 2785801 agactctgat tgagattcaa ccgcagtgta cttaataaaa agaacgagaa aacctgacac 2785861 caaatagagc acaagtgcga taagcatggt ataagaagga ctaataaatg taagaaaagc 2785921 gccgcataat gtgacagccc caagccggac aatttgagcg gaggattgca gcacagcgtt 2785981 tgctttttga atgccctgtt cattgacgat ttgaggaatc aaagcgatag aggcgggatt 2786041 gtaggcagct ccagtagctg aatgcacaat cataagcgtc atgacaaacc acagcggaga 2786101 gaagcccgca aaatgacata gagggataat caaaacaatc gccgcccttg tcagatctga 2786161 aaagtacatc caaaatttca gcgtggtctg tttcataaaa ggccccgtca caggcgccag 2786221 aacggcttcc ggcaaaaacg tgacagcaat caataaagca gtgccgatcg cacctttgcc 2786281 gtcataaatt aaaaaccata atattgaatt aaatgcgaac atatcgccgg atatcttgac 2786341 tattcttgag aaaaacagat aattgaaatt tctcttccag atgctatcac tttcaattaa 2786401 attcaccatc catcagagcc ccccgttgcc tattttttac atctatttat tacaatatct 2786461 catttttcca tttttcagtc aataattcat aaggttcatt ttttgtcgta aaatgggaaa 2786521 ttgacagagt gaaaaacaaa aaaagccggc atgtatttga acacgccggc tttccttttc 2786581 actttttatg attcgctgct gtttcggtcc cgaaacacaa tggcacttct ttcatattct 2786641 acatcgccaa taccgcttct tgcattcaca acccgggcgg cggcaaagaa ataatcggac 2786701 agacgattga gataacgcag cactgtttca tgaatctcct ccgatttcat cagcgccacc 2786761 actcttcgtt ctgcccgcct tgtaatggtg cgtgcgatat ggagaagcga agcacacttt 2786821 gatccgcctg gaagaataaa tttcttcagt tccggcgctt ctgctgtata ggcatcaatg 2786881 cgcgtttcta aaaaggaaac agattcttcc gttagtttat agtcttttct ttctgtgacg 2786941 attgccagat cgcctccgca gtcaaacagc tcatgctgga tggtcagcag ctcggctgtc 2787001 agatcttcaa agccgggctg cccggaaagc tctgccaaag caagcccgat aaagctgtta 2787061 agctcgtcaa tcgtgccgta gctttcgacg cgtaggctgt ccttgtccgt tctgcccccg 2787121 actaagcccg tttgtccctt atcgcctgtt tttgtatata gtttcatacc ctgaatctcc 2787181 tttacagact tattcaaaca actcagcagc ctcttttata cattcagctg tccctttctt 2787241 tatcaattgg ttcagccgct gttctatgtt ttctgattgc tgagtttgag tcgcggcgat 2787301 gagaatatca cctgtgcctc ctccgtctcc cagcactttc gtccgttctg cttcggcagc 2787361 cataagagct ttgatgaaga attgatctgc cgcatagccg ttaatcaaaa tccaaatcga 2787421 aaagccggtc tgaacgcata tgaaaacgga taactctccg tcttcatatg ttcgatacac 2787481 gaaacggtca agtctttctg aagaagccat cgcacacgtc tcctgcagtt gaaaaccgct 2787541 ttctgaaaga caggccgtaa gtccttctat cggatctggc tgatctggca gccgtttatg 2787601 gatcagcgtc ctgctccacg aaaaccctgc accgataggc gtggaggaca atgttcgaag 2787661 cgggatttcc gtttgcagaa gaatgtcatc acgccccgct tggagcaatg cttcaaatgg 2787721 gatagactgc cgcttcacgc tatctttttc aggctgaatc acaatcatcg gtttaggtga 2787781 gctttgatga accaaggcgg tgacatctgt atcgtacacc gcctttatgc tttgttctgt 2787841 aacagcatat tccggttttt gcttaggccc ggcggtaccg tttttcataa acatgagccc 2787901 atcacagtac aggcttgcgg tgttcagatc atgaaaaacg ctgacagctg ccaatccgct 2787961 ttctctcgtc aggcgtttga tcagatcaag caggtctttt tgataagcca gatcgagaaa 2788021 attagtcggc tcgtccaaaa ataaaatacg cggctgctgc gccaaagctt gtgccaaata 2788081 cacccgctgc tgttcccctc cgcttagttc gcgaatcggc ttttgcgcaa aatcggccac 2788141 tcctgtttgc tccattgctt cctgtacaat ggcttcaccc ttttcagtct gctgtctgaa 2788201 cagccccgtt tggaatggat atctgccaaa ggctacagtt tcttcgacag taaaggtgaa 2788261 ggcttgatcc attttttgcg gcaggacagc catgatttgc gccagttcct tcggtttata 2788321 gtccgccagc agttttccgg ccagataaac cctgcctttc ttggccggca gcgtacctgt 2788381 cagcaagtgc aaaagcgtgg tttttccgct tccattaggg ccgagaattc caagaaattc 2788441 tcccttctcc actgttaagc tgacattgtt gattaggcgg ctgtcgccgt atcctcccga 2788501 cagcccttct gccttcatca taagcttctc cccccgcgat gctgccgaat taaaataaga 2788561 gcgaacacag gcgctcccgc caaggacgta atgatcccga tcggcagttc aatcggctca 2788621 atgatggttc tggaaagcag atcggctaaa acaagaaacc ctgccccaag caaggcggac 2788681 aacggcagta aatgccgatg gtccgttccc cacaaaagcc ttgtgatatg cggaatcaca 2788741 aggccgacaa agccaatcgt acccgatact gccacagcgc ttcccgtcaa aagagatccg 2788801 gctattaaaa tcatcatctt cctctgctga acgctgactc caagaagctt tgctttatct 2788861 tctccatatg tcatcacgtt cagttccctt ccgtttataa tcaataaaat ggttcccaaa 2788921 agaaaaaacg ggagaaacaa aataacatag ctccagcccc tcattgagac gctgccaagc 2788981 agccaatgca caatcggaag caggttgtct cctgtcaagg cgatgataag agaaataaat 2789041 gcgcctaaaa aagagttggt gatgacaccg gtcaaaatga gggtggaaac agacatcgaa 2789101 gcatgaacga ggcggctgaa gaaaaggacc gccgccatcg tggccagtgc cgcggctaca 2789161 ctcaaaaccg ggagtgtaaa ccctccgatg acaggaaggt gcaaacctaa gaacagagtc 2789221 acaacagctc cgactgaagc accggatgac acacctagcg tatagggatc agcaagcgga 2789281 tttttcaaca atccttgaaa agcggcccct gcaatagaaa gagccgcccc cacaagggcg 2789341 gccagcacaa ctctcggcag tctgatattc atcataatat tagtgtacat cggatcatca 2789401 gaaccgatag agccgccgaa accttgatgc caaaagacac gaaaaacagc gggaatagga 2789461 atatgcaggc tgccgcaaga aattcctaag atgatgctca cggctaaaaa tgagaaacca 2789521 atgatatatg cggcataacg attattcctt aaacgtatcc gggtaaatgc tttccgcaag 2789581 ttcttcgacc ccttcgatca gacggggacc ggaacgtgtc acaagatcag ggtccacatc 2789641 atatacacga tgatgtttca cagcattgat ttcgctccag ccatcgcgtt tttccacagc 2789701 tttcgctttc acaccgtccg ttgtaacaat tgcatcagga ttgagtttta cgatcgcctc 2789761 gtctgtcatt tgcacccatc ctgtctgatc cgcagctgcg tttttagcat ggatgacatt 2789821 tagcatttca ttcataaacg tatcttttcc ggttgtataa atgtcaggat caggagaaac 2789881 ctcgataaat acgcttttct cctcgtcttt tgaaatggtt ttcgcttttt cttgaatatc 2789941 ctttagatct gatttcatgc ttttcacgag ctgatcggct tttttctccg ccccgccagc 2790001 ttctccgatc atttcgattg atttgtacac ctcggagaat gattgtgcat cattgacagt 2790061 cagcactgta atgcccgcgt ccttcagctg tttgatggca tccgctgatg ctgacatgga 2790121 agactcatgg gccagaacga gatctggttt tagagaaatg actttttcaa cgtttacatt 2790181 catatctccg actttctcaa cctttttgac ttcctttgga taggtatcgt ttgtggtgac 2790241 accgaccact ttgtcaccaa ggccgagtgc gtatgtaatt tctgtgttgc tcggcattaa 2790301 tgaaacaatc ttttttggct cttttttgat ggttacatct tggtttgacg catcatcaat 2790361 ggtgacaggg aacacttctg ttttttgttt tgcctttgaa tccttctgat ccgcaggatt 2790421 gccgcagcct gccagcataa cagcagccaa cagaagcgca gcccatatcc cggctcgttt 2790481 tttcataatc ttttcctcct aaacgaacta aaaaagcatc tctacgacgg taaagatgct 2790541 gtaaacaaca caaaaaagcc tattgtttac acatcatctg tcctcgcaga attcgtgctg 2790601 atcaaacagg caggtatcct ggctcttggc gcttggccaa ttacagtggc gggaccgcac 2790661 cggcttttac cggtttccct tttaagccgg ctgttgttca cggaccggca cctatttgac 2790721 attcgtatcc gtttttcgga gtaattatac tatatgactg acaggcttgt atatgtgtcc 2790781 tgaatgactt ttccccatat tgtgtatgga agcaaaatcc tcgtaaacac taaatttgat 2790841 cttgtatact taataccatc atctatcaaa aggaatgatt cttatggatt tacagctaaa 2790901 agaaaaactc gtcttaatca ccggctcgac gtccggtatc gggaaagccg ccgcaaaaag 2790961 ctttctgcaa gagggtgcgg cagtcattgt caacggacgc aaacaggaga ctgtcgatcg 2791021 caccattgaa gagctttctg gctatggaac agtgcacggt gctgctgccg atttgtcaaa 2791081 aacagatgaa gcagcggctt ttatcgaaaa agtaaatgaa atcggtgata tcgatatcct 2791141 tgtcaacaac cttggtttct tcgaggtaaa agacttcgcc gatgtgacag atgaagagtg 2791201 gaatcaatat ttcgaagtga acgtgatgag cgccgttcgg acaagccgtc acttccttcc 2791261 aaaaatgctt gccaaaaaca gcggccgcat tttaaatatt gcaagtgaag caggcgtcaa 2791321 accgctgcca acgatgattc catactcaat gacaaaaacg gcactgatca gcctttcaag 2791381 aggaatggct gaaatgacaa aaggcacaaa tgtgacggtc aactcagtgc tcccgggacc 2791441 tacttggaca gagggcgtgg cctcctatat ggaaggcgcc gcacaagcag ccggacagga 2791501 tacagataca tttatcaaag actatttcaa ggtcaatgag ccaacctcac ttattcagcg 2791561 atacgcgaca gcagaagaag tcgccaacac aatcgtattc ctcgcgtctg acgccgcatc 2791621 cgccattaac ggcacggcac agcgtgtgga aggcggcatt atccgttctc tgtagtataa 2791681 aaaaacgcat ccgtgtttcg gatgcgtttt ttttatacgt ctccagcaaa tggtaccggc 2791741 tgatatccgc ctgtttccag ttgtgctgaa aacaaccctc cagcgtgagg ctgctcgtat 2791801 ctctcttttt ctgtcatttg ttctgttgcc gttgtaatgt aaagggtttt taagtctctg 2791861 ccgccgaacg cgcagcacgt gacatattta gccggcacgc tgattgaatt gatttctttt 2791921 ttctgaaacg ggtcaatgtg aacaacgcgg ctgccgccaa acagcgccac ccacagcatg 2791981 ccattttggt caattgtcat gccgtccggc aatccgtctg actgatcaaa acgatagaca 2792041 ggttctggat tcgaaacatc tccgctttga ggatcatagc tgtaacgtac aatctcctgg 2792101 gtcggcgtgt cgatgtaata catcaaattc cgctcgcggt cccaatccaa accgtttgag 2792161 gtggagactt gatccttgat tttgacaaga ctgccgtcta gattcaaacg gtacagcgac 2792221 gcctgttttt gctcgccttc catgctcgtc gtccccgccc aaagccttcc gtacgggtca 2792281 catttagcat cattaaatct caggctctca tgcatgtcct tcggctgttt aattttttcc 2792341 aagctgtcat cccgaagatg atacaggtaa aacccgtcct tcatcgtcat aatcagttca 2792401 tcctttgaat atttcgcaag cgccgtcaca aaggatttga atttgattga tcggttgatt 2792461 ttttcttcag ggtcaaagat gtggagctcg ctccccagga tatcaaccca atataagcgg 2792521 ccgttctctt catcccataa cgggccttca ccaatcactg cccgagtgtc tgcttccaat 2792581 actgcatcca tgtgttacac ctctttagct tcagtctata tattgttatt cccggcaaag 2792641 aggtgtccaa accacttgat gtttattgtt ttttaaaaag gatggtaatg accgttccaa 2792701 tgttcgttct gctgttcaca tggatcgttc cgttatgcag atggacaagc tccttggcaa 2792761 tcgcgagccc gagacccgtt ccggcagttg aatcttttgt gttcgtccct ctgtagtagc 2792821 ggttaaacaa atgggtgatc gtttcttcat ccattccttt cccattgtcc ttcactttta 2792881 aagaaatatg attttttgtt tgctccagaa tgacttgaat ctctgttcct ttgccgttgt 2792941 gcttcacggc attcccaagg aggttttcta atatgcgcct gaaccacgct tcatcaaggg 2793001 caaattcaat atgctcttct ttggatacaa acgagatatc atagccttca gaaaacggat 2793061 ttttcttaaa atcctcaatg acatttttaa aaaacgggat aaggctagtg agctttctct 2793121 caataggaag agcatcattt ttcaggcgat acgttaaatt taagtcttca atcagcttag 2793181 acatgtattc agatttttct ctgacaacct gccccatttc tttcacttct tccggcgacc 2793241 agtcatactg cttcgactcg agcatcatgc tgtagccgta aatgctgctg agcggtgttt 2793301 ttaagtcatg tgacaaaccg gcaatccatt cttcccttgt cgcctggatt ttttctctgt 2793361 ttcttttatc ccttctcagc gtttcagtca gctgatccat tgattcaaat atctcaccga 2793421 agaagcggta cggctgtttg atttttccct ttttattttt gctgacagga cggccttccc 2793481 ggtttctggg ctcctcaagc ttcccttttg acagattgac cagccatcta atcgtgtgaa 2793541 aaatcggcag cccgaatcgg aacatatacc aaacggtcat ccaaatgata tacatgaaca 2793601 aaacggccat cacgagaaac atcgctttta atacaacctt caggaatgat ttgttaaact 2793661 cctgatcggt tacatagact gggttcggca ccgtagcgac catccatctg tctttattga 2793721 ggatcttaac ggaaatttcc cgcttatagt tccaaggctt agagctgtat ttaagcagct 2793781 ccagctggtt catcgttttt ctctcgcttt ttgtgctgtt gatgctgtcg agaatctttc 2793841 cattgctgtc taacaggtaa atggcgcctt ttttccgttt aatatagtcg atggtactag 2793901 acttatagtg cgctagtgag tctatctttt gttcacgctt ttcaacggaa gtcaggagct 2793961 gttcactttt tgatttccag ccggacaata gaagatacga cttatcttca atattgatgg 2794021 cccaataatt cagtttatag ttatgaagct ttttggtttt ataaatagac aaaagctctt 2794081 tcttggtata ggtgcccggc acgtcttttg gcacgccgta ggaataatca gtgtttcctt 2794141 ccgaatcaat gatttgcatc cagccgtgct gtttatcaac agatttcttc aggaaattat 2794201 ccacttccca tgtcccgtct tcgtttacat cgagatatgc ctcaagtgtg tcggtcgttg 2794261 ctttcgtcag ccctgaattg gattccgcat cgctaaaacg ggcgtctaaa tagaaaaacg 2794321 atgcaacaag cataaccgta agcagcagga tcacaatcag catctggccg aaaaagtgaa 2794381 acaaaaactt ccatcttaac ctcatgaccg cttgccttca ggatttggga taaaacgata 2794441 gccgagacct cgaacggtta caatatactc cggattgctc ggatcgcgct caatcttctc 2794501 cctaagcttg cgaatatgaa ccatgacggt gttgttgtca ccgtaggaag gatagcccca 2794561 tactttttca tatatttgat ctttggaaag caccacgtta gggtgttcac aaaaatactg 2794621 caaaagctgc agaagctggg ctgaacaggc aacggcttcc ccgcctacga tcaactcggc 2794681 attttgcgga gaaaaagtaa agtaatcata tgtgtaggtt tgatttgaac tcgtttcttt 2794741 cgattgatat gtacgcttga gatgcgctct gatccgcgcc gctaattcca gcggattaaa 2794801 tggttttgtg atatagtcat cagctccaac cgcaaagccc gataatttgt ccgcgtcgga 2794861 tgatcttgcc gtcaggaaaa aaatcggagc gtctgaatac tctctgatca atgtgcaggc 2794921 ttcaaaaccg gacattccgc ccatcatgac atccagcaca atcaagtcaa ccttattggc 2794981 cttcacaacg ggaatcgctt cttctgcgct tgccgcatcc agtatatttc gataaccttc 2795041 tttttcgaga acgcgtttga tcatgtccac aatcgctttc tcatcgtcta cgattaaaat 2795101 tgacgcattt tccactttta tgttcctttc tgtcactgtt tttttcatct tatcattata 2795161 tcgtttattt atggtacatt tttgaataca ttggagcctt ggcaaatcaa aacagcaaaa 2795221 aaggagcaaa caagcgctcc cttttgatgt tttttcatat gaaaatatta tgagttctca 2795281 tctaccatgt acaaaataaa ctcccaaaac cccggtacat cctgacataa aagcatatca 2795341 gccttttcaa acattttgat cttcagctct tgctctaaat cttctctttc ttgataggac 2795401 gtattgctga gtttttttct gatcatcggt gaaaagcatg caatcaggtg ctcaatgtca 2795461 taagtctcgt ctttttgttt ctttttttgt tcaaactggc cgtccacagc ttacttttcc 2795521 cccttttttt gcgccgctaa ctgctttctg atattctcca gccccttttt atgaatgttg 2795581 gagatgtttt gtcgggactc ccctaatgaa tctgcaatct cctgcatcgt ggcaccgtga 2795641 agatagactt tcgtcagcac acttttttgt ttgtcagtca gcttctggat cgcttggtag 2795701 agctggtaat cctgtacatg ctggctcaaa tcatcctgcc tgtctaaaaa ttcttcaaat 2795761 gcatcgctac ctgtttcgga agaaagccga tctcccgcct ccggatgatc aaccgtcagt 2795821 ggataccgtt tttggttttt gcgaacccgc ttatcaaaat caatagaaaa gatgcgaatc 2795881 attgaattca tatacttgac gatgcggatt tctttataaa attgcttaaa tagctcgtcc 2795941 aatgatcttg catctttttc gttagggctt tccattacgt ttttgaacaa acggtaatgc 2796001 tgaggattgc tcaaaaaatg cttcacgatg ggatgcttca ttatctcctt acattttgac 2796061 cgtaaaagac tttgatagtc catcaaaccg cctccctact aaattaaatg aaggaaagca 2796121 aaaaaaagta aactactact ttccgcctag tgtcttccaa aatactttgc agcagtttac 2796181 gttttatcgg ttttcctcac ttacatacat gactgcagaa aaagaaggga ggtattttcc 2796241 tatggatcag gtttttatag aggaagtcgt aaaacagatc ggcaatttgg ggtttcccgc 2796301 gctgattgca atgtatctgc tgacccgatt cgaaaagaag tttgatcaac taatagaact 2796361 aatgacagaa ctgaaagatc atgcaaaaaa ataatttttc aatcgaagtt gacttttcac 2796421 tggttttttt cacttaacaa aacagaaggg aaaacgaaag gcctttcacc ttctctttct 2796481 gctatcacat ttaaatgtaa ggaggaaaca tttcatgaaa aaacaaaatg acattccgca 2796541 gccaattaga ggagacaaag gagcaacggt aaaaatcccg cgcaatattg aaagagaccg 2796601 gcaaaaccct gatatgctcg ttccgcctga aaccgatcat ggcaccgtca gcaatatgaa 2796661 gttttcattc tctgatactc ataaccgatt agaaaaaggc ggatatgccc gggaagtgac 2796721 agtacgtgaa ttgccgattt cagaaaacct tgcatccgta aatatgcggc tgaagccagg 2796781 cgcgattcgc gagcttcact ggcataaaga agctgaatgg gcttatatga tttacggaag 2796841 tgcaagagtc acaattgtag atgaaaaagg gcgcagcttt attgacgatg taggtgaagg 2796901 agacctttgg tacttcccgt caggcctgcc gcactccatc caagcgctgg aggagggagc 2796961 tgagttcctg ctcgtgtttg acgatggatc attctctgaa aacagcacgt tccagctgac 2797021 agattggctg gcccacactc caaaagaagt cattgctgcg aacttcggcg tgacaaaaga 2797081 agagatttcc aatttgcctg gcaaagaaaa atatatattt gaaaaccaac ttcctggcag 2797141 tttaaaagat gatattgtgg aagggccgaa tggcgaagtg ccttatccat ttacttaccg 2797201 ccttcttgaa caagagccga tcgaatctga gggaggaaaa gtatacattg cagattcgac 2797261 aaacttcaaa gtgtctaaaa ccatcgcatc agcgctcgta acagtagaac ccggcgccat 2797321 gagagaactg cactggcacc cgaataccca cgaatggcaa tactacatct ccggtaaagc 2797381 tagaatgacc gtttttgcat ctgacggcca tgccagaacg tttaattacc aagccggtga 2797441 tgtcggatat gtaccatttg caatgggtca ttacgttgaa aacatcgggg atgaaccgct 2797501 tgtcttttta gaaatcttca aagacgacca ttatgctgat gtatctttaa accaatggct 2797561 tgccatgctt cctgaaacat ttgttcaagc gcaccttgac ttgggcaaag actttactga 2797621 tgtgctttca aaagaaaagc acccagtagt gaaaaagaaa tgcagtaaat aaaagacttg 2797681 cggcttgcag agagcactcg ttctctgcaa gccttcataa ggagctgaac cagtgaaaca 2797741 tcaaaaccct tcaaaacgct tattgcggct ctccataaag tacttgctgg ccgcagcagc 2797801 agtggtgttg acctattttg ctgtcatcta tatattgttt tctttagcgg gaacgagcta 2797861 ccgctcagca gctcatgtcc tgctttttgc cgtggtattc cttgttctcg gattatgctt 2797921 tgaaccattt gaacggctga tgatacatag ctttacattt ttcaagacag gaaaacgtct 2797981 attcattctc cttgctggca tcgtacagct gctgtttttg tggatgactg ctcatacaac 2798041 agaccaattg atcagcgaca tctggctgtc caccacagaa gaaatgattg tcgcagccgt 2798101 ttttttgatt ttagacaaat gcaactcggc tcttcccagc taaaaaaaga acgcattcca 2798161 attggatgcg ttctttttat tcatagcgaa gcgcgtctac aggctgaagc ttcgaagcct 2798221 tgatagacgg aagcaagccg aagataatgc cgactgccat tgaaaagatg agtgctccga 2798281 caacagctgg aatggagacg ataaaaggca tcggaaaaat gaccgtcagc agcttggcga 2798341 tgccgaagcc cgccagcaca ccgagtattc cgccaatgct tgtcagcacg acagcctcgg 2798401 ttaaaaattg aaataaaatc acacgccgct tagcaccgag cgctttctta attccgattt 2798461 ccctcgtgcg ctccgttacg gaaacgagca taatgttcat gacgccgata ccgcccacca 2798521 aaagtgaaat actggcgata ccgccaagca gcaatgcaaa tgactgatta aaggactcca 2798581 cttcctgcgc gatctcctga agatccatta cactgtactc tgctttttcc agctcagctt 2798641 ctgacagtcc ctgatttaaa agatctgcag ccattacacc cgcttcttgg atatgctcag 2798701 aagaatcagc ctgcacggca atctgcgttg gcgcgtcaaa tccttcaata agcggccaca 2798761 cttttttcgg cacgtacaaa accgggttcg catagtcgcc ttcaaacatg ctttcctgtt 2798821 gatttttttc tttaaaaaca cccacgacct taaacggcac accattcatc tcaatgcttt 2798881 tatgcagagc ttctccgtct ggaaacagtt catctctgac agcttcattg atcatcacta 2798941 cttggtgtgt gctgtttaaa tcgttttccg tcagctttct cccttcggtt attcggattg 2799001 gaaacatgtc gaagtaatca tcgtccactc catacacttg gggatacgaa acgttagtta 2799061 aatgaaaaac gctcgcgcct tctgacaagt aatataagga taatcctttg accatcggat 2799121 ctgatttgat cgcctttact gtttcttccg ctacaggcgg cgcggacgca tacgacacct 2799181 gagggccgcc gctctcctct tctccgccag acggctggta gacaacattg atggcgttgt 2799241 ttcccatgcc gatcatactt tgctttaact gctcactttg gcccttcagc attgaaacaa 2799301 tcgcgatgat tgccgctatg ccgataatga cgccaagcat tgtcagaatc gatcttaatt 2799361 tatgagagaa aatggattga aaggagattc gaatatgttc aagcatggct gatatcccct 2799421 ctctcatcta ataccaactc tccgtctctg ataaaaacgg ttctgtcagc ttttttggcg 2799481 acgtccgggt cgtgggttat cataataatg gtcttgcctt cccgatgcag ttcagaaaac 2799541 agtgccaaaa tttgttcact tgatttggta tcaagcgccc cggtcggttc atcagctaaa 2799601 ataaacctcg gctgattgac aagggccctc gctatcgcca cccgctgctt ttggccgccg 2799661 gacagcttag gcggtttgta ggagaccctg tcttttaatc cgactttttc cagcgcttca 2799721 tatgcccgtt gccttctctc ttttttcttc actttattgt agatcatcgg cagctcgaca 2799781 ttttgcagcg cggtgagacg cggcagcaaa tgaaaagttt gaaacacaaa cccgattgat 2799841 tcattgcgaa tttcggctaa agccccgtct ttccctttca atatatcgat ctggtcaagc 2799901 gtataggttc ctgaggttgg cctgtccaaa cagccgataa tattcattaa cgttgacttt 2799961 ccagaaccgg aaggccccat aatagctaaa aactcccccg cctgaacggt cagattgata 2800021 tgtttcaaga ttggaacttc ttcttttccc agcttgtacg acttcgaaat attattcagt 2800081 gtcagcattg actgtaacct gctttccttc cttgaccgcg ggatcaggat agatcacata 2800141 atcttccggc gtcaggccgc tcttaatttc caccatgtca ttttcatcag tctctccgat 2800201 ttcaacaggc tgcttaaccg ctttgtgatt ctcatcagct ttccatacgt acggttcgcc 2800261 gtcatcctga atgaccatgt cggacggcag cttgatcgtg tccgcatcag cattatcact 2800321 catcacttcg atgttgacat gatagccgac ttcaagacct ttatggctgt ctaataaaat 2800381 ggtgaaagga tagttagagg actggggatt catttcttca tcagcaaagc tttctgattc 2800441 ttcaccctcg cctgctcccg ctggaagctt gccgatcgag gtgacctttc ctttccactc 2800501 gccctcaccg cctgttttca gcgtgaccct gactttgctg ccttttttga tcgtgtccat 2800561 taacagctca ttgatttggc ttttgaccag atatttgcct gtcgaaacaa tctggatata 2800621 cgggcctgct gcctggtcgc ctgttgcacc gtcagcgata tcctgattga cgctttgaac 2800681 gattccgtca tgcttgcttg taatgacatt ggaacctttg tttttcgtca ggccagccag 2800741 ttctttttga tgctgcttca gttcaagctg gcttgttttc aaatcgaaat tggtttgatc 2800801 aagttcatct tgaagctggt ttttctcttc ttttcctgca actttcagct ttttttccgt 2800861 ttccgttatt gatttttgca aacggttgat ttgcagattt gtcatttcaa tttgcaaatt 2800921 ggcttgctcc acttcatcag aatgatcctc gccctcatac tcaaaaagct tatcgccctt 2800981 tttaacctga tcgccttctt tgacgtatgt ttttttaatg ctgccttttt ctgaatctat 2801041 gtatactttc tgctgtttct caggttcaac ctttccagaa aacgtttggc ctgattctga 2801101 atctcctccc atgtataccg cgaccgattc agcatagggc tccgatgata cggcaacttg 2801161 gttcatgtga gtaaaaaagt aaaaaccgcc agcgccgatc ccagccaata caagcacacc 2801221 ggcacatatc gcaccgccaa taagccattt tttcttcttg gacacaacga tctcctcttt 2801281 ctgtaaacta tgtaatattt tcgaaacatt ctaaccaata ttatctatta attcaaaaag 2801341 acttgcaatc cttttattga aatgacggaa tcaaatagaa aaattgtatt ttcaaagccg 2801401 aataaaaaaa atcccggctt caaaccggga ttttttcata cagtaactag ctctttttca 2801461 tttttaatca agtcatatgt caagcataca ggtttatttg tacggggatc agtcacgatt 2801521 tcggcatcaa tctgaaatac ctgcttcaaa atgtctggtg tcatgacctc cagagcagtt 2801581 ccttccttga tgaccgtgcc ttttttgagc gcgatcatat aatgagaaaa acgagctgca 2801641 tggttaagat catgaatgac cattaaaatc gtccgccctt gctctttgtt gagtctgtca 2801701 agcagctgca gaatttcaag ctgatgtgca agatcaagat acgttgtagg ttcatccagc 2801761 agaagcagtt ccgtcccttg cgcaagcgcc atggcaatcc acacacgttg acgctgtccg 2801821 cctgacaatg cctcaatcgg ccgttcagca tattcagcca tgcctgtttc ttcaagcgcc 2801881 catttgataa tccggcggtc ttcgtcattt aatctgccga atcctgattg atgcggaaac 2801941 ctgccgtacg acaccaattc gtgcactgtt aggccgctcg gcgcttcagg tgtctgtgga 2802001 agaatcgcca tatcttttgc aatgtccttt gtagacattt tatgaatcgc tttgccgttt 2802061 aaatagacgg cacctgcatg tgaacgcata attctggaca ttgtttttaa aatcgttgat 2802121 ttcccgcagc cgttcgggcc aattaaggtg gtaattttcc ctttaggaat cgatatattt 2802181 aaatcctcta caatcaccct gtcgccataa ccgattccaa gctgttccgt tgataatgaa 2802241 ttcatattcg gccccctcct ctaattcgct ttcatcaata aataaataaa gtaaggcgca 2802301 cctagcacgg aaatgacaag tccgaccgga atttctgatg gtgccaatac atttctcgcc 2802361 agcgtatcag caagcaaaaa caggaatgag ccgatgaagg cggagaccgg tatcagcgtc 2802421 tggtgacgtg gaccggtcag ccttctagcc acatgcggcg cgatcaatcc gagaaacgca 2802481 atgccccccg cagctgccac gcatgaagcg gcaagagtga ccgctgccag aagaagaatc 2802541 cgtctttcct tttcaacagc ggtgcccagc ccggtcgcca attggtctcc gagctgcata 2802601 atgttcaaat agcgtgcctt atataaagta aacagaagca agatcacaat ccaagggaga 2802661 atcgcccaga tcatattcca gttcgccccc catattgagc cggatatcca aaccgcggct 2802721 tgcataaaat catgagggtc catcttgagc tgaaaaatca gcaacagggc gttgaatccg 2802781 gcattcaccc ctatgccgac taaaatcagc cgaatcggtg tcacgccttt tttccatgcc 2802841 agaatataaa tgagaaacgc agcgaggatt gctcctgcca aagcactgaa cggcagcata 2802901 aatgttccga aaaagctaag atctgaagct gacccttgaa aaaagtatat aaaaagcact 2802961 acagcaagtg aaccgccggc gttaattccg agaataccag gctcggcaag ttcattttga 2803021 gacacgcttt gcaaaatggc tccagctacg gagatccctg ctccaacaag caaagaaagg 2803081 atgatccggg gcagcctgaa ctcaaataag acaagttcat cacgcgccgt tccttggccg 2803141 aaaaagacct gaagcgtttt aagcggtgca attttgataa cgcccaaatt gagactgata 2803201 aaaaagacca ccacgataag caaaaaggtc acagccatta caatgagcgg tttgtttgtt 2803261 tttgttttca ttacagccct ctcctttcac gacgtgccaa ataaaagaaa aagggaacgc 2803321 cgataagaga agtcagcgcg ccgacaggcg tttcaaaggg cgcatttacg agtctggccg 2803381 ctatgtcagc aaaaacaagc aaaacagcac cgagcaccgc cgagcaagga atgatccacc 2803441 gataatccac accgaccaaa aaacgggtaa tatgcggaat gatcagcccg ataaatgcaa 2803501 tggtgccggc aatggaaacc gcagctccgg tcagaattac tacaataagc atgccaacca 2803561 gtttcaccgc tgatgtatat tgtccaagcc cttttgccag atcgtcaccg agacttaaca 2803621 ctgtaacaga ccgggcgatg aaaaacgcga gcgttaaacc gacagcccct gcaataagca 2803681 aaagctggac ccccgaccat ttcacacccg ctaccccgcc tgcgtaccaa aagctgatat 2803741 cctgagcgac atcaaagcgg attgcaatgg cagttgaaat gccggtaaag aaataagtaa 2803801 ctgccgtacc cgccagagca agctttacag gcgtaagtcc gccccttgaa aacatgccta 2803861 tgcccattac cgtcgatgcc cccagccccg ctcccgcaaa ggaccatagc acaagcccca 2803921 ttgcagaaag tccgggaaaa aaggcaaacg caatcgaaac cgcaaacgca gagcctgatg 2803981 tcacacccat aatcgaaggc tctgccaaag ggtttctcgt catcccctgc atgattgctc 2804041 ccgacactgc caacaatgcg cctacaagcg cggcagccgc cgttctcgga agccgaagat 2804101 catgtataat ttggtgagat gtctttgtcg gctgataatg aaaaatggcc tcccatacag 2804161 tgcgcaaatg aatatccgct gcacctaggg atatggataa aaatgcgcca aggcaaagca 2804221 ggcatagacc tgcgataagg acgatgaccg cgccatatgt ccttgacgtc cattggattt 2804281 cttctgatgc agtccgtata tttttatgtt gactcaactg ccgtacttcc tttctgttac 2804341 tgataatgat tatcaattgc tgtttcagta tatcactttt ttcagctgat ttaatagagt 2804401 gttttgaaca aaaatgaaaa tgcatttgca aaaatatcgt gtcaaccggc acttgcagtg 2804461 gtataatcac agatgataat gattctcttt ttcatctatc ttttagaaag aaggtatgag 2804521 atatgaccca tatatacaag aaactcggag ccgcgttttt tgccctgtta ttgattgcag 2804581 cgctggcagc ctgcgggaat aactcagaaa gcaaaggttc tgcctctgat tcaaaaggcg 2804641 cagaaacctt tacatacaag gctgaaaacg gaaatgtaaa aatcccgaag catcctaaac 2804701 gggtggttgt catggcagac ggctattacg gctacttcaa aacactcggc atcaacgttg 2804761 taggtgcgcc tgagaatgta tttaaaaacc cttactacaa aggaaaaacc aacggcgtcg 2804821 aaaacatcgg agacggcact tcggttgaaa aggtcattga tttgaaccct gacctgatta 2804881 tcgtctggac aacacagggc gctgatatta aaaagcttga aaaaattgcg ccgactgtcg 2804941 cagtaaaata cgataagctc gacaacatcg aacagctgaa agaatttgca aaaatgacgg 2805001 gaactgaaga taaagctgaa aaatggctgg ccaagtggga taaaaaagtt gcggccgcta 2805061 aaacaaaaat caaaaaagcg gtcggtgaca aaaccatttc cattatgcaa acgaacggaa 2805121 aagacattta cgtatttggt aaagactttg gaagaggcgg aagcatcatt tacaaagacc 2805181 tcggcctgca ggctacaaag ctgacaaaag aaaaagccat tgaccagggg ccaggttata 2805241 caagtatttc attagagaag ctccctgact tcgccggaga ttacattttc gcgggcccat 2805301 ggcaatcagg cggtgatgat ggcggcgttt ttgaaagctc catttggaag aacctgaatg 2805361 ccgttaaaaa tggccatgta tacaagatgg atccgatcgg attctatttc acagacccga 2805421 tttcattaga aggacaactg gagtttatta cggaaagctt gactaaataa acaaaagagc 2805481 cgcctgcccg cggctctttt gcttatttat aaggaacggc tcaatttgaa tcatatcgga 2805541 tattttcttt gagccattca tattaagctg catcctcatc acgatcagtt tttttatgct 2805601 ggagagactg aaaaacgttt tttgcatatt taacgaacgg attcctaaca ggagaaattg 2805661 tgattttata aaaaagacac ctgagcaaat caggtgtctt ttcattatgc ttgtttttct 2805721 ttctggaact tgttactcac aaatggataa acgattaagc cgacaaagaa taaaccgatg 2805781 ccgagtataa atgtcgttaa atctgctgtg cctgttacga taacaaacac ggagtatgca 2805841 cacgccagta tcgcgatcaa tccgtctctt acacgggagc ctttcagctg gtcatacgtt 2805901 tcacctttga tgactacctt caagctgtag attgcagata ccagatacgg aattaaatat 2805961 gcgagtgtag ccgctgtcgt taaaaatgta aatgcgtcac ttattgtccg ggaaataacc 2806021 gagaaaatga agacctgtga catgacgttt gtaataatga gtgcaatgac cggacttccc 2806081 tttttattcg tttttgcaaa aaatgccggg aaatctcctg ctttagcggc ttggtatggc 2806141 acctcagagc caagcaaaat ccagccgagc atcgttccga ataaacaaag gatagccaaa 2806201 agcgccataa tcacgcttcc cgcgtttcca acaatcgcat agagtacatc aacaaatggt 2806261 ttttcagagc cgacaagctt atcatgcggc agaacaccca tcgtaattaa agtcacaata 2806321 atatatatgc tcaaggcaat cagcaagccg gtaattgtcg cacgtttcac atcacgctga 2806381 gagcgcgcac ggccggacag gatcaccgcg gattcaattc cgacaaacgc ccacagtgta 2806441 gaaatcgcag cgttatgaac ctggccacca attccaatgc ttgtgccgtt ttctccttga 2806501 accgggaaat aaaaatgacc gaataatgac gtttgaaaca caaacaaacc ggcaacgata 2806561 aagaagacaa aacctaatac tttagaaagc gttgtgacaa agtttaattt acttgcgccg 2806621 ttaatgctgg caacaagaat cgcgtgcgtt ccccataaca agatcgtaca tacggcaaac 2806681 gtcagtaatt ggccgagtgt cacctcttgc ccgccgatcg aaaacatctc acgtttatca 2806741 accaagatcg ggaagaacga agtcaagtaa ccggcgagac ttgtgatgat cgccacgtta 2806801 ctgatccagc tcgccaccca gtagccccac accattgtga aaccggcagc gttgcctttt 2806861 ttcgggtcag aaaacagcgc tcttgcataa ctttgcggtc ccgctgtcag ttcaggcttg 2806921 cgaatggaca agtgtccgaa cacaagtgca atcatcagca cgccggcacc tgtcaaaagc 2806981 caggcggacg tagctccaaa cggactcgca attgaagcaa gcgagctcgg caaggagaaa 2807041 attcctgatc caaccatatt tccaacgaca aacgccgtta ataaccaaaa accccatttt 2807101 tttgtctgtt ccattccagt acctccatga ttctttgtac ggaccagacc ccgagatcat 2807161 ataaacgcaa aaaaagcctg aacaaaagtc catgcttaaa gaaacacaca cccttgatct 2807221 ccggatagcc ctccgcgaaa aagcacgcgg cagtcctgca cttattcaga tacagtccca 2807281 gcatagagaa ggatcggctt tctccacact tcggcgctga tgccttttac acatgtttaa 2807341 cagcccctgt cagcctagca tgtgtgactc atcatccgcg caacctctac ctcactgaga 2807401 aagagtgagg atttaattat tcagttactc ccagaaggtt atcaaagaaa ggatgatctg 2807461 tcaaagggaa cagatggaaa atacggatag agccaagccc tatccgcatg tggttatcga 2807521 ttatttttct ttttttgcac agcttcttga agcggatcat cttttagagc tgaaccagca 2807581 tcttcaagag ctccttggat tacgtttttt tctttttcgg aacgttttcc tttatcttta 2807641 ttaaagaaac ccattcgtat cacctctttt aaaaaatagg tacatgttta agatgccttt 2807701 ttcctgaaaa attatgcggg atatttttta tcgtccaaag tcctgttgat caaacataca 2807761 ttctcttgat atatttgtaa ttcagagatt ttttgcaaaa gataaaagga gaagcggcaa 2807821 atgacaggaa aaacacacat catgggaggc atcgcttctt gtacggcagc ggcttattat 2807881 tatggatttg atccagtgct tatggctgcg tcaggcgcgg ttggagcatt aatacccgat 2807941 atctgccaca cacaaagcaa aatcgggaga aaatttccta ttttatcgaa agtggtcagc 2808001 tccgtttttg gccatcgcac ctttacacac agcctgctgt ttatgctcat catgtttttt 2808061 atcacttcta catacattcc agataaaaac atatcagccg gcctgatgat cggaatggcg 2808121 agccacttga ttcttgacgc ttggacggtg aacggaatca aattattatt cccttccacg 2808181 atccgcgttc ggcttccatt atatatgaag acaggcagtt tttctgagca gctcgtgcta 2808241 gccggcctga cccttgcttc atgttactac ttttatatgc tgtttcatgg ccgcatgttt 2808301 taaacatgag tgctgagact tgtctgaacc ggctgttttt agtaggtttt acttaagaag 2808361 catttcatgc agatgatcaa gaaaacgtga ggagtcatat tgatgaaagg aacctttttt 2808421 cacaatcagc ggtttttatg tttttcgatc ttatttatgt ggatcaaaac gtatgtgata 2808481 tataaactcg gctttgattt gcaaatcgat actctgttgg aggagctaat gctgctggtc 2808541 aacccgctca gctttattct tcctttattc gggatcggcc tgtttctaaa agaaaacaag 2808601 cagcgggcct ttttgctgat tgccaatttg gttctgactg ttatcttgat ctctaatacg 2808661 attttttacg gcttttatat cgattttatt accatcccgg ttttatttca ggccagcaac 2808721 atgagcgata tgggcagcag tgtaaaagaa ctgttccatc ctctgtttat cgccctgttt 2808781 gtggatttgg tttttctgct gttgttcgcc agaaaaacca aacacccaca gacaaaagcc 2808841 gctccccaca cgatcaaacg gtactatgca gcttcctgcg gaatgctttt atgcacactg 2808901 gcacttgcag aagtacagca gccgaagctt ttggcacatt cttttgaccg ggaaatgcta 2808961 gtcaaaagca tcggcctgtt tcagttccat atttacgata caatttctca gactgttaat 2809021 atcagcgcga aagcttttgc cgatgaagac agtataactg ccattaaaaa ctacacagag 2809081 gctgattaca gcaagcctga tcaaagcaaa ttcggtcttg caaaggggcg caatgtcatc 2809141 tttgtaacac ttgagtcgac ccaaagcttt gttctgaatg aaaaagtaaa tggaaaagaa 2809201 attaccccat ttatgaatga tctcataaaa aaaagctatt cctttgatca tttctatcag 2809261 caaacagaac aaggcaaaac atcagattca gaatttatcg tcgctaactc actgtatccc 2809321 tcccttagcg gcgccgtctt tttcacgaaa agcgaccatc aatttcatac gatgtataaa 2809381 tcgctgaagc agcacgatta ttattcagcc gtctttcacg ctaaccataa aacattttgg 2809441 aacagagatg tcatgtacga tacatttggc attgaccgct tttttgatgt tgatgatttt 2809501 catgtcactc ccgggacatc gacaagctgg ggcttaaaag acaaagaatt tttagagcag 2809561 tccgccaaaa agctgaaaag cctaccgcag ccgttctaca gcagttttat cacgttaacg 2809621 aatcattttc cgtttgagat tgatgaaaag gatcagctga tagatgaatt cgattcaagc 2809681 agtgatctgt taaaccgcta tgtgaccacg gttcgctatg aggatgaagc attgaagcat 2809741 tttatcaaaa aactgaagga cgaaggctta tacgaaaatt cgatgatcgt atttatggga 2809801 gatcattacg gcatttctga agcccataac gaggcaatgg ctgagttttt agggaaagac 2809861 gaaatcacac cgtatgacaa cgttcagctc cagcgggtgc cgtttatcat acatatcccg 2809921 ggaatcaccg atcaacagcc ggaaaccatc cctgatgccg ggggacaggt cgacgtcagg 2809981 ccgacgctga tgcatttgct cggcgttgag acaaaaggcg atatccaatt cggcaatgat 2810041 ttgctgtcgg gcgaccgcac cccattcgcc gttctgcgaa acggcagctt tattacgaac 2810101 gattatgtat acacaaagaa cacgtgctat agccaaaaaa caggtgaagt gctggaagat 2810161 caggatgcgt gcctccctta caaggagaaa gcaaacgaag aactgtctct ctctgataaa 2810221 attttaaatg gtgacctgct caggttttcc gaatgaaaaa atccctctat caagagggat 2810281 tttttacgtt tccaatatca ccttgccagt cagcttcgtt tcatagccgt ttaaatgaga 2810341 cagattcgcc ttgtagtcct cagaattcaa aatctccttc acggctttga gcaactgctc 2810401 attttttttc aaaacaacga tatcatattg ttcgtcgatg agcgggataa aatcaacact 2810461 gcccatatgt gccgcgtgct gtgccccgat tcccgcgtca gcctgtccgc ttgaaacttg 2810521 tgaagcggca gcgtaatgat cagtcacgat atcgccatat cccactacat cagccggatt 2810581 cacaccaagc aagccaagct gttcatcaag gagcaccctt gcgccagaac ccttttccct 2810641 gttgatgatc cggatatcgg ctcttttcaa gtctttccag ccttgaatgt ttttcggatt 2810701 ccctttttgc acatacagtc ctgctttgcg gagaacgaca ttgatgagac aaaacggttc 2810761 acctgtcaaa atccgtttta cataaggcgc gttatactgg cccgtttctg catcgtacaa 2810821 atggaggctg acaatgtcac acttgccttg atacatatca atcaggctgt ttaagcttcc 2810881 tttgtattta cggagcggcg tctcctgaat ggcattctcc aaatgcttgc tgaggatatc 2810941 catcgaaatg tcctgtccgc tgatcatgac atttggtctg ccgtccggct cagcctcctg 2811001 cacctgtttc ggcgcttctt ttgcagcgat gggctgagac attctcatat tcgttttata 2811061 ttgctttaaa tcttcttcat ccacacgcat ctgccttccg acacggtaag caggcagcac 2811121 gcctttttta atcaagtcat aaacggtcag ctttgatacc ttcagcagac ctgcaacttc 2811181 ttctatcgta taggaagagg tttcattcat catcatcact ctcctatttt attatacctt 2811241 ttcgccgaat gtaaaaaaac ccacataaac caaacataat cagttataat tagttatatc 2811301 taatgataag gggtgcaatc atgtttaaga agtattctat tttcatcgca gccttaactg 2811361 cttttctgct tgtagcaggc tgttcttcaa accagtcttc aacggacagc gagaaaaaag 2811421 taacgttaac catctcagct gccgccagcg cgcaggatgc acttgaggaa atccaaaaaa 2811481 attatgaaaa agatcatcaa catataacca tccaagataa ctatggctca tccggcgcct 2811541 tgcaaaaaca gatttctcaa ggagcaggag cagatctgtt cttctcagct gctgaggata 2811601 aatttaaaaa gctggtggat gatggagata tcgcaaaaaa agacagcact gaattagtcg 2811661 gtaatgaaat tgtgctggtc gtaccgaaaa acggagattc acctgtgaca agcttcagca 2811721 atctggctga atcagaaaaa atcgctcttg gcactccgga atccgtaccg gcaggagctt 2811781 atgggaaaga atcactgaca aagctgtctt tatgggacaa agtgaaggat aaaattgtgt 2811841 atggaaaaga cgttcgccaa gttctttctt atgttgaaac cggcaatgta gacgcaggtg 2811901 ttgtttataa aacagatgcc ctagtctcga aaaaggtcaa cattgttgac gaggcaaaag 2811961 cagatacaca cagcccaatt gtctatccgt taggaatcgt aaaagataca aaacaccgta 2812021 aggaagcgaa ggaattttac gaatacctgc aatctgatga agcaatgaaa gtatttgaga 2812081 aatatggctt tactgccgag tagcataagc gcttcagaat ttttcacacc cgttgtgctt 2812141 tcctttcagg tggcggcagt tgccggaatt gttgtcatta ttctcggaac acttgctgga 2812201 gcatggatgt cacgggcatc atttttcgga aaaacggcac tcgaaacatg ttttatgctt 2812261 ccgctcgttc ttccgcctac tgttgtcggt tttattctga tcgtcatttt cggaaagcac 2812321 agcttcatcg gacaagccat cgagtggatt ttccagcagc ctgtcatttt cacctggtgg 2812381 gccgctgtga tcgcctcggc tgttgtagcc tttccgctta tgtatcaatc agccaaaacc 2812441 ggatttgctg acattgatcc cgatatacaa ggtgcggcaa tggtagacgg cgctagcaga 2812501 tggaaagtgt ttatccatat ctccgtcccg cttgcctatc cttcgttact gaccggaagc 2812561 atccttagcc ttgcgcgggc gctcggagaa tttggcgcaa cactcatgtt tgcaggaaac 2812621 atccccggtg ttacgcaaac actgccgacg gcgatatatg tcgcattgga ttccggcaac 2812681 aatacccttg cttgggcgtg ggtcgtctgt attgttgtca tttccttttt gatgctgttt 2812741 ttcattcaac agaaaaaaac gcactaaaaa aactccccat aacggggagt tttttgatta 2812801 aaacagaagc tcatcaggat ttggaccgac acgctcatct ttatttaatg cgtcaatttt 2812861 gtccatgtct tcttgagaca attcgaaatc aaaaatatca gcgttttcga tgatacggtg 2812921 ttctttaatg gattttggaa tggttacaac tccatgctgc agatcccagc gcaaaatcac 2812981 ttgagccaca gatttattgt gtttttcagc aatctgtgtc agtacttcgt tatccaaaag 2813041 ctgtccctgc atgagcggag accacgcttc cagctgaatg ccttgccctt tgcagtaatc 2813101 tcttaattct ttttgcgtca agcgagggtg aaattcaact tggttcacca tcggtttgat 2813161 ttcagcatct ttcaacagct cttctaaatg atgaacttgg aaattgctga cgccgatcgc 2813221 gcgaattttg ccgtctttgt acagcttttc aagcgcgcgc catgtatctt tatatttatc 2813281 tttgccaggc caatggatca aatataaatc taagtaatca agctgcagtc tttctaggct 2813341 tttttcaaag gcagcaagcg ttgtttcata gccttgatct tcattccaca cttttgatgt 2813401 gatgaagagc tcttctcttg ccacaccgga ttctttaatc ccgatgccaa cgccttcttc 2813461 atttttgtag atcgctgctg tatcaatact gcgatagcca tttttaattg ccgctttcac 2813521 tgattcagtc gcttcattac cattttctac tttaaaaacg cccagaccga accaaggcat 2813581 ttcaactccg ttatgtaact ttacagtatc ttttaaactt gttggcactt gaacctccac 2813641 cctttcactg aaatgtaagc gtctatatta tctcacattc ctctcagccg ataccaataa 2813701 tacgcttaag accctctttt tgcttctttt ttcacagcac aggcaaatcc aaacactatt 2813761 tttttcctat tttaacaata ttgagattac aaatacattg agcagggtat gcgtgtagtg 2813821 taaccaaatg aaaacaaagg aggaaacaac ttgaaacgta ttcgtatccc aatgacactt 2813881 gctcttggtg ccgctttgac aattgcccct ttgtcctttg cttccgctga agaaaatcct 2813941 gctccgaaga tgtcgcagac aactactgct ggaacaactg ccgctgatgt aggtttaaac 2814001 gtcaacctgg atgtacttgg aattgccaac cagatcgctg atgccatcaa atccgcacag 2814061 aatagggatg gctttgtgaa aaacctcatg gagtcttcct tctacgcgtc cggccaaaaa 2814121 tataacgtca tggtctttaa tttaagccag gaatatgaag atcatttgaa cggtgtgcaa 2814181 ttttacggct cagccgttta cgacggcatt acgtatggca tttgggtatt tgaagatgga 2814241 acctttacaa acaaaggcga tggcggctgg atcaactggg ccttcagagg ctggttcgac 2814301 cgggatggca gcactgtcgc atttcatcgc ccttaatata aaaaaagctg gcgctctaac 2814361 gccagctttt tttctgcatt tattcgccgc cttcaagcat ggcggcttcg acatcattaa 2814421 tgtattggcg aagctcatgg gagatgtccc gggaaatttc cctctcttcg aagagcgttt 2814481 gaatttcatt tctgatcgcc tgcacagcct tcagcttcac ttccagcttc tgattttcaa 2814541 aatgggcact tgattttaac tcatgatggc tgtgctccag cctgaaaatt aactgcttat 2814601 agaatgtaat gacagataaa aacacttctt tatgctcatc cgtcttatgt ttttccagat 2814661 attctatcgc tgcttttgcc gttttcactc ttgttgcccg tatcaatccc gcttcattta 2814721 aaatcgacat ctccggcttt ttatgttcac cgaagaaaat ccaatacatc agcctcttga 2814781 gccttgtttt tgataacccg actttaaacg ggttggcata caaaatttcc aactcgttaa 2814841 atcgttcttg cagcacattt gctgtttctt ccgggatgtc tccccgctcc agcattttca 2814901 tcagcgcctc ttgctcagcc ttaaccccct gcgcacggac ttttcgctcg tgcttcttaa 2814961 tgcgattaga tgatgtatac tgctgaaaac gaagattttt cattttctca ttgtattcag 2815021 ctatcaccgc aagagaggcc gttttgtttg tctcattcat gtcctcttta atcgtttgaa 2815081 gggctgtttt gatcaacttg cgtctcgccg tcagcagctt cttatttcgt tcctcgtcct 2815141 cttcttcttt ttcagtcaga attggcagca caacggtggc aatgacaagc gtgcataaaa 2815201 tgacgccggc tgctaaaaag agaatcagat ttctttccgg aaacggcgta ccgtcctcca 2815261 ggaaatacgg aatggaaaaa gaacctgcaa gcgttactgc tccacgcaca ccggaaatcg 2815321 aaattaacag cgtcgaacga agacccggtt tatagatgtt ctgatcttta ttaaagaacc 2815381 atttgccgtt ccagaagaac agcacccaca ggaatctaag gagcattaat gtaaatgtga 2815441 tgactaggat atagccgatc accttcatgt tgctgatggc agtgtcgtta aagataacag 2815501 aaataacatc agggatttgc gtgccgagaa taacgaagac caggccgttc aaaataaata 2815561 aaataatgtt ccacgtactt gaggagacga tttgcagctt gatcatcgtt gattccagac 2815621 gatcctgttc aaccgcatgg gtaataccgc cagctacaac agctaaaatg cccgaaacgc 2815681 cgatttcttc agctgccaaa taaatcacaa acggcgtcag aatttgaatc agcatatgca 2815741 tcgtgacatc ctgcatgcca aggcggcgca gaaataggcg aaaacgaata atcaaaaatg 2815801 aaatgacaac cccgcacagc aagcctccga gagaaataaa gacaaagctg acagccgctt 2815861 gtgctaatga aaatgcacca gtcactgccg ctgcaatcgc aaacttaaag gccaccagac 2815921 ctgatgcatc attcatcagc ccctcacctt ccagcaggcg aagaatccct tttggcattt 2815981 tcactcttcc tgataatgcg ctgacagcga cgacatcagt cggtgaaaga atggccgcaa 2816041 gtccaaaggc cgctgccagc ggaatagcag gaatcatcca gtgaatcgtg tagccgccta 2816101 caatcacagt cgcaaataca aggccgagtg caagcaataa aatcggagcc cttaaattcc 2816161 aaagctctgc ccgcggtgtc ctctttccat cattaaatag cagaggcgcg ataaaaagaa 2816221 caaaaaacaa ttcggtgttt aattcaaaat gaagtccctg tggaaatgag gcggcaagaa 2816281 tcccaagagc cacttgaatc agcggcaccg gaataaacgg aataaaccgg ttcacgatat 2816341 tagaaatcgc aataatcgtt aataatacga gcacaactaa aaatatgtcc aaatgcatga 2816401 cctccttcgt ctgttgtgtg tcggcatgat gagccaaaaa atctgtttgt ctaaaagccc 2816461 ttgagctagg gtggccttgc atccgctatg tggtttcgca ggagttctct ccacacttgt 2816521 cttcttttat agtacccttt ttagggtatt ttttctcatg atatgctcac agtgaacttt 2816581 tttgcagaag agcaaattat agaaaaaaga gacaggaagc tactccctgt ctctcgtctt 2816641 tctttctcaa tcatgaaaat tcgtaccgtc agttgttgct ttaataatgc ccgcgcgaat 2816701 gacaaagtca ccgaaatgct cgccttcctc gcgttctttc gcatagcggg aaagaaggat 2816761 gcgcagctcg cttaaaatgt ctgcttcacc gatgttttca cggtacattt tgcttaaacg 2816821 gcttccgtca aacgcagcgc caagatacat attatatttg cccggcgcct ttccgataaa 2816881 tccgatctca ccgagtgcat gacgtgcaca gccgttcggg catcctgtca tgcgaatggt 2816941 gatttcctga tcacgaaggc cgttttcgtc aataatctct tcaatcttat ctaacagggt 2817001 cggcaaataa cgttctgctt cagccattgc caatccgcag gtcggaagag cgacgcacgc 2817061 catcgagctg cggcgaagcg ctgaatagtg cttgccgtca gttagtccgt actgttcaat 2817121 taaagcactg atttcttctt ttttatcgct tgaaacgttc gcaatcatta agttctgatt 2817181 ggctgtcagc cggaactcac ctgtatgaac tttggcgatt tcccgcaagc cagtcatcag 2817241 cttataatca tcgtaatccg ttatacggcc gccttcgaca aacagcgtga aatgccattt 2817301 atcctcgatg ccttccaccc agccatagcg gtcgccgtta tgatcgaaat gatacggctt 2817361 cgcttcttcc aggctccagc cgagacggtt ttccaattct tcttttacgt tttctaaacc 2817421 gaggcggtca actgtgtatt tgaaccgcgc atttttacgg acagaacggt tgccgtaatc 2817481 acgctgaatc gtaatcgttt tttcagcaac gtcatacatt tgctcaggcc ggcagaaacc 2817541 gatcaccttg gctaattgcg gatatgtcgc agtatcgcca tgcgtcattc ccataccgcc 2817601 gccgattgcc acgttaaaac cgatcagctt gccatcctcg acaatcgcaa tgaatccgag 2817661 atcttgtgaa aagacgtcaa tatcattaga cggcggaacg gcaataccga ttttaaactt 2817721 ccgcggcaga tagagcggtc cgtacattgg ctcgacttct tcctccggcg tgccggcaac 2817781 tctttcctca tcaagccaaa tttcatgata tgctctcgtc cgcggcagca gatcatcact 2817841 taatttttta gaccactcgt atacctctga gtggatttca gattgataag ggtttgatgc 2817901 acacatgacg ttacggttta cgtctccgca ggctgcgatc gtatccaaaa gtgctgagtg 2817961 gatcgtctga atggttttct tcatgttcca tttcagaatt ccgtgcattt ggaatgtttc 2818021 acgtgtcgtc aattttaatg tgccgttccc gtatttctgg gacaggtcat ccatgacaag 2818081 ccattgttca ggcgtcgaga cgccccctgg catacgcacg cgcagcatga actgatatgc 2818141 gggctcaagc ttctgctttt ggcgttcatt tcggaggtcg cggtcatcct gcaaataact 2818201 gccgtggtgt ttcatcaggc ggttatcatc atccggaatt cccgcactga ttcgatcgag 2818261 catcacttct ttcagcgtgc cgcgcaaata atcactttct tttttaatgc gttcaacatc 2818321 acttggagag ccgtccggtg cttttagaat tttggtcacc atgttgaaaa actcctttca 2818381 agtcaaatca atatacatca cgctgatagc gtttttgctg ctgcatatcg gcaagataag 2818441 cctccgcctc ttcgcggctc atattgcctt ctttttcgat aatttcaagc aatgtgttat 2818501 ggacgtcatg cgccatgtgc ttttcatctc cgcaaatgta aacagccgct ccttcttgaa 2818561 gccattcaaa caattctgcg ctatgttcaa gcatgcggtg ctgcacatat actttttctt 2818621 ccgtatcacg tgagaacgcc acatccattt ttgtcagcac accgtctttg agccaattct 2818681 gccactctgt ctggtaaagg aaatccgtga caaagtgctg atcgccaaag aacatccatg 2818741 cctttccttc cgctcccgtc tcctcacgct cctgcataaa cgaacggaaa ggtgcgacgc 2818801 ctgtcccagg gcccaccatg ataatcggtg tttcagggtc tttcggaagc ttaaagtttt 2818861 gattgtgctg tacataaacc ggcagtgtgt ctcccggctg cagtcgttcc gcgcacaaaa 2818921 tcgagcagac gccttttcgt tcacggccgt gcgcatcgta gcggactgcg ccgattgtta 2818981 agtgcacttc atccggattt gcggataaac tgcttgcaat cgaataaagg cgggcaggca 2819041 tttttcgcaa aatcgagaca aactcctgcg cagatacact aaatgggcca tagtcacgga 2819101 cgagatcaag caaatcgcgc ccttcaatat aggcttttac attctcctca tttcccgggg 2819161 ctaaaagctc tctaagctca tcgttccctg tcagctgggc tgcctgttca agaagcggtt 2819221 ttgtgagaac ggtaatctca tagtgagaaa tcagcgcttc tttcagcggt cggacatcac 2819281 cttgcttatt aagcgtcaca atttcttccg ggtcccaatt catttcctta aggagcagct 2819341 cgacaagttc cggatcgttt tccggataga cgccgaggct gtcaccaggc tcgtaagtca 2819401 ggccagatcc ttcaagagac agctccacat ggcgtgtttc tttatttgat cctctgccgt 2819461 ttaaatttaa attttctaac acttcagccc gaaacgggtt tgttctggaa tacgaagact 2819521 caccggtttg tgacgcagcc gccggcgcag gcgcggcgct tccgccccca gcttcattta 2819581 atcctttcaa tacaccctca agccattcgg ctgccggttc atcatagtca agatcgcaat 2819641 caacgcgcgg agaaatccgt tttccgccga gttcttctaa gcgttgatca aattctttcc 2819701 ctgtctggca gaaaaattcg tacgaactgt caccaagcgc caaaacggaa aagcgcaggt 2819761 cttcaagctt aggcgcccgt cttccgtgca gaaattcatg aaacgacagc gcgttatcag 2819821 gcggctcgcc ttctccatgc gtactgacga cgattaaaag attggttacc ttcttcagct 2819881 gattcggctt aaaatcgctc atggatgaga cggtcacttg aaaaccgctc tgttcaagct 2819941 gcttgccggc attttctgca agcccctgtg cgtttcccgt ctgtgaacca taaagaacgg 2820001 tcacttcttt tgaaacggcc ggtgccggtg cttccgctga cacagctgcc gccggcgtac 2820061 ccgcagcttc ttgggcggaa acagattgag cggataaata tccgctcagc cagattttct 2820121 gggattcggt caaggtcggc agaaggcggt taaggagctc tgcctgctcc tgattaaacg 2820181 gactgttcat tacctgaagt tgcaacgtat ccacctcaca aagttataaa ctgatcgaaa 2820241 attgcatcta attgaacttt accggaatac taggcttaag taaaatatat ttacatgatg 2820301 ataactatta agaatcctaa tgataaaacg gctatgcttc atgtaaatag aaaaaagaga 2820361 aggactccct tctcttcatt cagcaatctg atataagtga ggcggcacag cggttacaaa 2820421 cggactggct tcacctgtat aaaataccgc cagcatgtgc atcgcacggg tgcacgcagt 2820481 atataaaagc ctgcggtcgt gctctgtatg atagtgttct tcagatgcat catagacaag 2820541 cactgcgtca aattcaattc ccttcgctaa atacaccgga atcacgcaaa cacccttttg 2820601 aaatggttga ttttctttat gaatcaggcg aacatctgta tattcactca tgtgggcgtg 2820661 cgcctgtatg cattgatgcg cagtcttgca gatgacggct attgtttcgt gccctttttt 2820721 cttgagccgg ccaatttctt gcgcgagctt ttggcaaagg ctctcatgtc cttcagtttt 2820781 gacaacgagc ggcatttccc cgcttctatt aaacggctca atatccgctc catcttgaag 2820841 catcgctttg gtaaactcga caatctgcct tgttgatctg tatgttctct ttaaacgaac 2820901 atactcagca ggctcatcct caaagcacgc atccatacgc tgatccccgt ttatggtatg 2820961 cgcgtagatg gactgattga tatcaccgag cactgtcatg ctggcagccg gaaaaatgct 2821021 tctcatgtaa gccatctgaa acggtgaata gtcctgggct tcgtcaataa atagatgttt 2821081 gattttcgta tttttctttc tgccctcaat cagatcctgc atataaagaa acggtgccgc 2821141 gtcctcatag agcaatttat tatccgtaaa tgccgaacgg gtcagctcac ctatcgcatc 2821201 catcttctca tgttgaaatt ttcctcccca gccagaaaac aattgcaaat aaagttgtgt 2821261 aacatcaaga aatgcaagga gcctgactgc ctgtttgagc ggtttgaaag cttttttcac 2821321 aatgatggcg gcaagcagct gctgctctct ttgataatcg ttaaacgtac tctcgctgaa 2821381 ccgtttcctt tcctgcagtt ttttgtacac gtccaagtag tcctctttgt caagcagctc 2821441 agcttcatga acaacccaat cctttcgccg ttcctttttc tcaagcttgt taagctcact 2821501 cagcagccac ttcgcggttt gctccatccg attcggaatg gagtgatttt gatccaatga 2821561 gtaaaaatag gattgaattt gctcctttgt gatcagcttt tgtccgcgga atataatatt 2821621 tttaaaaatc atcccttcag aggaaagccg tgtgacgtat tcattaatga attgctgaaa 2821681 ggataaaccc gccttccatg tgattcctgc aagccttgtt ggaaaatcgc ctccctttgt 2821741 ttcggtcagg caatattcga gctgatcaaa ggggctttca catttgaact tgcggccaag 2821801 acgatgctcg atatattcct gaaacgtcgc ctgctccata ttctcttctc ctaactccgg 2821861 caaaacagag gagacatagc tgttaaataa gaagttgggt gaaaacaaaa cgatttgtcc 2821921 ggcatcaatg acaccgcggt gcctgtataa caaataagcg acacgctgaa gcgcagccga 2821981 tgttttcccg ctgccagccg ctccctgcac gatcaggatc ttgctttttt cattacggat 2822041 aatctgattt tgttctttct gaatcgtaga cacgatgttt ttcatttggg tatcagagtg 2822101 atggcttaat acctcttgca gcatttcatc gccaatcgtc atatcggtat taaacatcgc 2822161 cttgagagtg ccgtttttga tcataaactg gcgtttcagc accatttccc cttctatcgt 2822221 ttcaccgggc acctcgtact ccgcttttcc tggggaataa ttgtagtaca aacttgatat 2822281 cggcgccctc cagtcataga tcagaaagtg ttcctccttc tcatccaaac aggaagctaa 2822341 accgatataa attcgctctg cctgctcctc gccgttttca ataaaatcaa tccggccgaa 2822401 ataaggcgat tttttcaatt gatgaattcg tttgagctgc tgatccatgc gccgatgatt 2822461 gtgttcccga tcagacagca gctctgcctg ctgcttaatg ctagccatcg tttcaatcgc 2822521 ttcatgggca tcatcaaaat taaccttaac atcctcccaa aagctttttc ttaatccgat 2822581 gatatcatgc ttcaacccgc ccgcagacgt ttccagaaac cgctcttttt tttcgagctc 2822641 cttcagcacc tcatctattc tcgactgctc ttccttccat tccttatcct gctgattcat 2822701 gaacggcacc tccagaaaat agttgacaaa catagatgaa atactgtaaa atataattgg 2822761 atacatatat taaatatatg atgcaaactg gcaaatacaa tttataatag cacattcacc 2822821 caataccaat caaggtttgg gttatttata ttatgcagaa aaaaaccgat ttcacttcga 2822881 aatcggtttt tttgctatta attatctaag cgaaaagaac ggtttggcag cttccaatta 2822941 aacatatagg aacaaacccg gcaaacaacg agcacgaaaa acagaacgta taagccgaac 2823001 gagttcccca gccagcccaa gccgacgatt aaaccgccga gcgccgccca taccgcatag 2823061 atttccgctt tcagcacaag cggtttgcgc ccggcaagaa ggtcgcggat gatcccgccc 2823121 ccgcttcccg tcagcaccgc agccacgatc acggcactaa gcggatggcc cattttgacg 2823181 gcatacagtg cgccttggat agcaaaggca gcgaggccga tcgcatctga taaattgccc 2823241 cacttattcc aatgcttcag cagcagcttc ggaaacagaa acacaattgt aatagataaa 2823301 agcgcgattt gaaagtacgc tccctgctcc catagcgctg acaccggaac accgatcagc 2823361 aaattgcgga tcgctcctcc tccaaaagct gtgacaatcc ctaatatata aactcctaaa 2823421 atatcatatt cctcttccat cgcaacaatt gcgccgctga ctgcaaacgc aatgatgcca 2823481 atcacactaa gcagctccca agccattctg atgactccct tttatgtttg ttaaattttc 2823541 tgacgacctc tagattttat aatcgctcca gcgtaaaatc aataacattt tcatgagaaa 2823601 aaaagataaa tttagaggga atacggctat tgctgatgga catgagtttg cgaaattaaa 2823661 aaagcgcccg gcatacgcgg gcgctttttt tgttattcag atttttcgcc tttcagcagg 2823721 cacataaaaa tgataatcag gataaaagca atcagggcca ggaatggaat cgtaataaaa 2823781 ccaaaccagt taatatattg gcccgagcac ggcacgccgc tgacacatgg cttaatgccg 2823841 ctaaagccgg gcactttttg ctctaagtaa tgcatgatcg aaatgaatgc cccaataatc 2823901 gccatcggga gcacatattt tttcactcgt gtgtcccctt gaaaggtggc gatgcctaaa 2823961 atcaggacga gcggatacat gaggatacgc tggtaccagc acagttcaca tggaataaac 2824021 tttctgattt cactgaaata caggctgccc agcatagcga taagagccac aacccaggaa 2824081 gcatataaaa atacgattct atttttcata ttgttacttc cctttcagct ctttttctat 2824141 tgtctctttg atttcatcat aatccgcaaa atttttgatc actttatcat tgacgtaaat 2824201 cgtcggtgtt gcctgtatgt tcattttttg attaaggtca gaatcctttt ccacttgaga 2824261 agcgaatgtt tccttatcaa gattttcctt gagcgtctca ggttttatct ttgtggtgct 2824321 ttttgcaaga tcaccaagga ggcctggggt tacccattcc tgttccgtat ccggctgttt 2824381 ttcgaacagc ttttcatgga aatcccagaa agagtcaggg tcttccttcc atacttcttc 2824441 agatgcaaga gccgctaacc ttgaaccttt tccatggaac atgacgttca cgaaagaaaa 2824501 tttcacatcg cccttatcaa taaagtcttt ttgtattttt ggaaagatgt cactgttaaa 2824561 caccttgcaa gacggacatt tgtaatctcc gaattctact acagttaccg gtgcatcgtc 2824621 cttgccaagc acaggctgcc ctttgataga cggctgtccg gacaccgcat cattgccttg 2824681 ttccgttttg ttattaatga tgacaatggc tgctagcaat acaacaacca caaccgtaag 2824741 gatgaccgcg aatttcgcag aagactgctg tttctttttc actccgacac ctcatcgttt 2824801 taaaattaaa aaagaagcgg atcgcaattg acccacttct ttattttaac aagacaagcg 2824861 ctgataagaa aaccccgaaa aaatgaattc tctccgacaa tttatttgtt tttgagacgc 2824921 atgacgcgca tggcgttcgc cacagcaagc agtgtaacgc cgacatctga gaaaaccgct 2824981 tcccacatgg tcgcaattcc aaatgcacca agaatgagaa agatcgcttt cacacctaaa 2825041 gcaaagccga tgttttgcca cacgattcgc cgtgtccgtt tcgcaatccg aatcgcttct 2825101 gctatttttg acggctgatc tgtcatcagc acgatgtctg cggcttctac cgcggcgtct 2825161 gagccaaggc ctcccatcgc aacccctata tctgcgcgtg caagcaccgg cgtatcattg 2825221 atgccgtcac cgacaaaaat gagtttttca ctaggcaaaa gcttagcttc taatgcttcg 2825281 acctgcgcga ctttatcttg cggcagcagc tctgcatata cctcaccaat cccaagctgt 2825341 tttccgacgg cttctcccgt ttgtttcgaa tcacccgtca gcatagctgt ctgtttgatc 2825401 ccaagcgact tcagatcagc aaccgcctgt gctgcgtctt cctttatctc atccgctatg 2825461 atgattgctc cggcatagcg ttgatctaca gcaacgtgta cgattgttcc agcattttca 2825521 tccgggacat cctcaatttg ttctctttcc atgagctttt tattcccagc aaggatctca 2825581 gttccattta cctttgcaaa aatgccgtga ccggagattt cttcgtatga ctcaatctca 2825641 tcggaggaaa gcattttccc gtaagcttta cgcacagatt cagcaatcgg atgctgtgaa 2825701 tgaagctcag cgtatgccgc cgcttcaagt aatctatcct ttgtaaaacc ttccgcgggt 2825761 ttgatttctg tcacttcaaa gctgcctttt gttagtgttc ccgttttatc aaacaccgcg 2825821 tatttgactt gattcaaagc ttctaaataa ttgcttccct ttacaagcac tccggccttt 2825881 gaggccgctc cgattccacc gaagaaaccg agcggaatag agacaacaag cgcacaagga 2825941 caagaaatca ctaaaaagat aagcgcgcgg tacacccaat cggaaagcgc ggcgccagaa 2826001 agaacaagcg gcggaacaaa ggccagcaat accgcaatga tcaccacagc aggtgtataa 2826061 tacttggcaa acttcgtgat aaagttttct gtccgggctt tacggctgct cgcattctga 2826121 accaagtcta atatttttga tactgctgat tcctgatagc cctttgtgac ttcaatatgc 2826181 agaacgccgt tttgattgat aaagcctgac attacatctt gtccttccgc agcttttctc 2826241 ggaacggact cacctgttaa agcagatgta tcaaccatcg ctgacccttg cacgacctta 2826301 ccgtccaggg gtatgctttc tcccggatta accacaatga tgtctcctgt ctgaacgtcc 2826361 tccgacgaaa cctgttcgat gccgttcttt gttttgagat tggcgtaatc aggccgtatg 2826421 tccattaacg cactaattga ttttctggaa cggctgaccg cggctccttg aaaaagctca 2826481 ccgatttgat aaaacagcat aacggcgacc ccctcagggt attgctgaat cagaaaagcg 2826541 ccgattgtgg caagagccat taagaaatgc tcatcaaaca cctgaccgcg gatgatgttt 2826601 ttgactgcgc ggattataat gtcaccgccg ataatcaaat aagcaccgag gaaaaggaaa 2826661 aattcaatgg ttcccgactg aaccaaatat gccgctgcgc cgagaatgac agccgccgcc 2826721 attctgatca gcatattgac cattcgatta cgatagccat catcagctga tttctttata 2826781 tgcttttggc gaaccgttac atgcggatca attgatttca cttttttctc tactttattc 2826841 gtgacccatt gctcttcttt cccatcggct gagacagtta aggtgcttgc cgcaaaattt 2826901 accgcgcatc cgttaatgcc ttttatgcct ttgactccat tttcgatttt tcgggcacaa 2826961 ttgctgcaat ccaaaccgtc cagaacatat tcctgtttca ctagtctcac cttaccttcc 2827021 gatttagggt tccctcttca aagcgtatca atgagtattg tatttatttt atatatatga 2827081 gcatatactc atatataagt tacacctatt atatgttgtt ttccaagaaa gtgtcaatga 2827141 aaaacaaaaa ccggcatata gccggttttt cattttactt tttgcagacg aagagcattc 2827201 agaacaacgg aaacggagct gaatgccatt gctgctcctg ctatccacgg tgctaaaaat 2827261 ccaagtgctg cgattgggat gccgaggctg ttatagccaa gcgcccagaa taagttttgt 2827321 ttaatgtttt tcattgtcaa tctgctcatg cggattgcgt cggcaatgct gttcagatcg 2827381 ccgcgaataa gtgtaatgtc tgctgtttcc atggcaatgt ccgtgccagt tccaatcgcc 2827441 atgccgatgt cagctgtggc aagcgccggc gcatcgttaa ttccgtcgcc taccattgct 2827501 gtctggcggc cttctttttg caagcgggcg atttccgccg ccttttgttc aggaagaact 2827561 tccgcaatga tattcgcaat tcccgcttcc ttcgcgatgg cttctgcggt tctgcgattg 2827621 tctcctgtca tcatgatgac atcaagaccc aactctttca gacgggcaac agccttccgc 2827681 gacgtatcct taatcgtatc tgcaactgct actagccccg ctgcttctcc atcaatggat 2827741 acaagcataa ctgttttccc ttcggcctct agctcttcca tttgggcgag aagagcccca 2827801 tgctcaacct gttcgctctc cattaatttt cttgtgccga cgagaatgct ttttcctccg 2827861 gcttcagcca aaatgcctgc gccgactttt gcttcaaagc gggtaagttt cggtatctca 2827921 agccctttat ctttcacgcc agcaataatc gcttcgccaa gcggatgctc tgatcccgtt 2827981 tccgctgccg ctgcaaattg aagcaaatct ttttcttcaa aacggccgaa tggaatggca 2828041 tccgtcagac gcggcttccc gtttgtcacg gttccggttt tatcaagaac aattgtatcg 2828101 agacgatgtg ttttttctaa atgctcgccg cctttaaata aaatcccgaa ttcagcagcg 2828161 cgtccagatc cagccattat gctcgtcgga gtggcaagac cgagggcgca aggacaggca 2828221 atgacaagaa ccgcaatgaa cttgctgatc gcttcggcaa aatcgccagg agccgcccaa 2828281 agataccaaa tgagaaaagt gagaaccgca atccccaata caatgggtac aaaaatgcct 2828341 gaaatctggt cagcgagacg ctggatcggc gcttttgacc cttgtgcttc ctcaacaatt 2828401 ttgatgatat gagaaagcgc agtatccttt ccgacgttga cagctttaat tttcagaaag 2828461 ccgtttgcgt taacggttga acctgtcacg ctgtcaccag gatttttgtc aacaggaaga 2828521 ctttctcctg taatcatcga ttcgtcaacc gctgaacggc cttcaaccac ttctccgtcg 2828581 acaggaattc gttcgccagg tttgacgtaa acaatgtcat taacaagcac ttcgtcgatc 2828641 gggatgattt gctcctgtcc gtctcttaca acagtagctg ttttcgcttg aagcttcatc 2828701 agctttttaa tcgcatccga ggaacggcct tttgcttttg tttcaaacaa cttgcctaat 2828761 aaaatcagcg tcagcaaaat cgcgcttgtt tcataataaa ggccgtctgt atgcccgtga 2828821 gagccaatgc tttgaaaagt tagataaaga ctataagcgt aagcagccgt cgtaccgagg 2828881 gcgaccaata catccatatt ggcgctttta tttctaagcg ccttatacgc acccacataa 2828941 aacggccagc cgatcagaaa ctggactggt gtcgccagcg caaactgcat ccacggattg 2829001 agaaatatat ccggtaccca aatgaatgat gtaaatgtaa aatggctcac catcgcccaa 2829061 agcaatggaa atgacaggac agctgaaaaa atcagtctcg ccgtttgctt ccgttcttct 2829121 ttctttttag cagcagcctc actgtcctgt tcacccttca actttagctt atatccaagc 2829181 ttatctaccg cttctttcaa atcgctgaca gacgcttctt ttggattgta ttcgaccgta 2829241 actgtttcta aagcgaagtt tactggtgca tttgcgacgc cttctatttt gttaagccgt 2829301 ttttcaatcc gattggcgca agccgcacag gtcatgccct caatatcgaa ttcagctttt 2829361 tctgtaacga cgtgatagcc cagcttctct attttttcct gaatcgctgc agtccctgtt 2829421 tcagcaggat cgtagattac atttgatgtt tccgttgcca gattaacatt tgcatccgtg 2829481 acaccgggca tccgcttcag gcctttttca attctggcag cacatgccgc acaggtcata 2829541 ccagagacct gcatcgcgat ttccttttgt tcactcaaca tactcactcc tttatataca 2829601 cctggggggt atataaaaat gaaagaaata tcgcgcctcc ctaaaggcgc gataccttga 2829661 atcacttggc tacgtcatag ccctgatctt ctatcgcatc cgcaatatct ttgactgata 2829721 ctttgtcagc atcaaacgaa acatcgactt tacccgcttc cagattgaca tgaacggcac 2829781 tgacgccgtc cagttctcct acgcttgttt ctactgcttt gacgcagtgc tgacaagaca 2829841 ttccttcaac ttgcaatgtt ttttgttcca tatcaattcc tcctgtttat tctttctatt 2829901 ttcatcctac catacccccg tagggtatta caataaaaaa cgctttatga ttttgtgaac 2829961 tttttaaata cgtccaaaag ctcagaaatg gcctgttccc cgtctccgct tttgatggca 2830021 tctgctacac aatgatgggc atgatcctca agcaaatgaa gcgccacatt tttcattgcc 2830081 gcctgaacag ctgaaatttg cacaagaata tctacacaat atctgtcgtt ttccaccatg 2830141 ttttgaatgc ctctgacctg gccctcaatc cgcttaagcc ggtttgtaat ctgatccttt 2830201 tctttcgagc ttttatggtt taatgtttta tgttcgttat gcttttccat gcgtacacct 2830261 ctgtttaatg atattaattc ccattatact gattgtccaa acggttgtct aagcatgccg 2830321 acgcaaaaaa tgaatcagtt aggttttacc atttgatcag gagggtatat acttctgttg 2830381 ataacgcttt taaaggggag aagaaaagtg gatacgatca aggttggaat attaggatac 2830441 ggattgtccg gttctgtttt tcacgggccg ctgctggatg ttctggatga atatcaaatc 2830501 agcaaaatca tgacatcacg gacagaagaa gtgaaacggg attttccaga tgctgaggtt 2830561 gtacatgagc ttgaagaaat cacaaatgac cctgccattg agcttgtcat tgtcaccacc 2830621 ccgagcggcc ttcattacga gcatactatg gcatgcatac aggccggaaa acatgttgtg 2830681 atggaaaaac caatgacagc aacggccgaa gagggggaaa cattaaaaag ggctgccgat 2830741 gaaaaaggcg tattattaag cgtatatcat aaccgacgct gggataacga ttttttaacg 2830801 attaaaaagc tgatctctga gggatccctt gaagatatca atacatatca agtttcctat 2830861 aaccgctaca gacctgaagt tcaagcgcgg tggcgggaaa aagaaggcac tgccactggt 2830921 acgctgtatg atctcggctc ccacatcata gaccaaaccc tgcatttgtt tgggatgcct 2830981 aaagccgtga ctgcaaacgt gatggcccag cgggaaaatg ccgaaacggt tgactatttt 2831041 catttaaccc tggattatgg caagcttcaa gccattctat acggaggatc aatcgttccg 2831101 gcaaacggac ctcgttatca aatccatgga aaagattcta gctttatcaa atatggaatt 2831161 gacggacagg aagacgcact cagagcggga agaaaaccag aggatgacag ctggggtgcg 2831221 gatgttccgg agttttacgg aaagcttaca accattcgtg gctccgacaa aaaaacagaa 2831281 acgattccat cagtaaatgg ctcctacctt acttattacc gtaaaatagc ggaaagcata 2831341 cgagaaggtg ctgcgctgcc agtcactgct gaggaaggta ttaatgtcat ccgcatcatt 2831401 gaagccgcga tggaaagcag taaagagaaa cgaaccatta tgctggagca ctaaaacaaa 2831461 agcctcccca aataagggga ggctttttca ttagaatgtt tttcctgctt ctttcgcacg 2831521 cgcaatcgcg tcttctttga tttgctgtgc tttatcaggc tccgcattat gtccctctac 2831581 gaaaatgcca tcgaatgatg gtacgccgaa gaagttcatc atgatgccga tgtagcggtg 2831641 ccccatttcc atctcagccg cagggccttc tgaatagtag ccgccgcgcg cttggatatg 2831701 aattgctttt ttatcagtta acaagccgac aggaccttgt tctgtgtatt tgaatgattt 2831761 tcctgcaaca gcaacagaat cgagatacgc tttcatcact ggcgggaatg agaagttcca 2831821 taaaggagta acaaatacgt acttatcagc tgatgcaaat tgatcgctaa gctctcccaa 2831881 acggcctact ttcgcttttt cgctttcaga aagctcttca aagcctgtac ctgactgaag 2831941 ctttccccat ccgctaaata catctgcgtc aatgtgcgga atgttttctt tgtacaaatc 2832001 gatatgtaca acttcatcat ttggattcgc ttctttgtaa gattcgataa atgctttacc 2832061 tgttgccata ctgtacgaag ttgcttcgtc atgtggatga gcagtgatat ataatacttt 2832121 tgccattttt accagccctt tcgtttttaa aaatcacaca tcaattatta tcatacagat 2832181 gcataatgat tattctgtct ctcttagact ttattataga gacaaagaaa tttactttca 2832241 agtaaaacat ctcgaattaa agattattta actttcccaa acagcttact tttcaaaagc 2832301 tgttctcaag ccggaataca gcgcggacaa ttctttactg atccgaggat aatgagggac 2832361 atgcggcact tgaatatccg caggcatcct tttcatgata aaggattgct cagcctgttc 2832421 aaaaaacgcc cgcagctggt tgatctcttc atcagaaaac ggagcagacg gacggcggtg 2832481 agcttgcgcc gagagcaaat agtaccctaa gtgctgagca ccggaaatgg caggccagag 2832541 cgcatccgca ttcgcgtgag gaaactcgcc aagcgccttg tcatacgcat cccgaagcct 2832601 gacaagactc acccttaact tgtgttcgtc ggcaatttgc ccggttaaca gtttctccat 2832661 aaactgccct tccagccgga tgacattccg cacaagttct ggcagccgct tggttgaaaa 2832721 ccgccgccac aaaagcattg ttcccaacag cccgatcacg ctgccgacag ctacatcagt 2832781 cagcctcgct atcataaaat aaccggcgcc cgccccgcca tgcatacttt ctgtgataac 2832841 aagcgcattt gcggttaaaa agggaacagc cagcgcataa ttgcggacga tcagcatctc 2832901 aagaagacat tgcagcgctg caatacaaaa cgcaatataa acaccgcccg gcttaaaaaa 2832961 caggattgcg cctgccagta taacaccgat caccgttccg gccgaacgct gaatagccct 2833021 gtgaagcgta aaaacaacag tagtgccaag catgaccgct gctgccgaaa gcggaatcca 2833081 ataggagcgt gcaaagccga atgcgagggc aaacatatcg gcggcaaaca gaacaattcc 2833141 gtactttaac gctctaatca aaactggaga cttccagtca aaggcatttc tcaaaaagta 2833201 aaaagaggat ggcaggcggc ttggttcccc gtcaagctgc ttatcaaaac gtcctgaagc 2833261 gatatacaaa acctcattga tttcttcaaa cagcttccgc ctaggctcag attcattttc 2833321 attaatctga aacgtattga aaacccgtgc attcgcaagc atatctccgg tttggcgaag 2833381 tgccttttca atctgcgcgg tctctctgtc cggcgtttca gctgaaaaat gaataatggc 2833441 aataaatatg tcgtcagctt tctcaaggag gcgaaaaaat cgttcatcat gccgcgattt 2833501 tttccgtctg ttccctttcc caagaaccgt ttggcgggct gttctaagca tgagcaccgt 2833561 ctgatgctgt gcgttatgaa aacctggcgt tccgacggct gaaagacatg cagccagctg 2833621 atgatatgtt ttttgcagca ccgctccctc cggtccatgt ttgttccata accagccgat 2833681 taaagcgata cccatggcga aaatgccgcc gagaaacgtc agtcccgctc tgaacagcgc 2833741 ttgtgaagga tcggccggca gcccggaact gactaaaaag gcaaggacaa aaaacatcgg 2833801 cgcagggcct tgaatgccga gcgcgctaaa aataaacatc gccgctgcac cgatcagccc 2833861 caaaacagcc gccatcatcc aaagcatccc ggacaaaagc gtccctaaac caaatgagag 2833921 ggcgatccca atagaaacca agagcagctt caaggcgcgc tttttgtacg attcaccgcc 2833981 cgcatataaa taaacaaagc ctccgatact tgcaattaat ccgtaatccg tgtgacctgc 2834041 caatgcaccg accagcacag gaaaccctga agcgaaacct gatccgatag cctttttcca 2834101 aggaaatgga tttgcatgaa tgcgaaaggc atccttcacg ataggcatga ttctttgatt 2834161 gttcgcagca gttttgttca tttgacaaaa tccttttcaa tgaatgtgta gaacttttcc 2834221 agtttcttcg ctttagtatg cccaaaaacg cggttagctt ctcaattggt gcgcacgata 2834281 aaaaaacaga gacttatacc gtctctgctt cattacatca gtttattata aaagcggcac 2834341 ctgtcaggac tgttttgtcc ttctgccttc cttcaagagc aggtgaataa aaaataaagg 2834401 ataaatcaat agatacccat taaacagcca ccacacaaga tcaaagtcac tgctgaatgt 2834461 ccagaatgat agcgcctgca gacctgaaca acaggtcagc acaagagaaa tcagcgccat 2834521 cagcttccag tcagcacgat tcacccgctg taggtacaag ctgtacaacc ctgtgacaga 2834581 aatcaggata tccagcggaa aaaaagacca gttccaagcg atcataaacg gatggtcatg 2834641 atgtttaaaa gcccagcttt ccggtatgag cgaaaatccg gctgacagcc agtacaagat 2834701 aaaaccgata tcagtcacga gaaaaaacag cttcatatat ctcatttgta ctgcccgctt 2834761 ttatgtaccg gctcagacac cgcaacatgc tcgatcaggt ttaaagacac aacaccggca 2834821 ataatcaatc caattgaaat gactttcatg acactcacat gttcttgaaa aaacaaaaaa 2834881 ccaacgactg taatcaagac aattcccatc cctgaccata cagcataagc aactgataca 2834941 tcaatggatt taagcgtaag cgtcagaaag aaaagactcc ctccataaaa gaaaatcaac 2835001 agcaaactgg gaataagctt tgtaaaacca gacgatagct tcatgctgac agttcccgca 2835061 acctcaaaca aaatcgccaa gcatagaaac acccaattca tgtggcatca gcctcctcat 2835121 cagctgttat accgttaaac aaaacatcta caattgattc aagtacctct cctgtcgtga 2835181 actgatgttt cagcggatat tcagggtcat acacttgatt gatgctccct atatacatgt 2835241 gaacaaacag gtccggattg atgtttctga ttctcttttg ctgtttgcac tcatttaata 2835301 atgctaggac aatcgcccat tcttccttaa taaacgcgtc taatgtaagc cacgcatcgt 2835361 aatggtattt ctttagttca tttaataatc ccatgttcag cagttccatc ccctgcggaa 2835421 ggctgatcag catttgtttc accttttcga gcacatttaa actttcattt tcatagatgt 2835481 ctctttctat ttgcttcatt tcagctataa attgttcgac aaccgcctca acaagctgat 2835541 ctttagatga ataatatgca tagagcgtcc gcttgctcgt tcccagcgct gccgccaaat 2835601 cattcatcgt aaatgaaaat cctttctgct tgatcagccg gaaggtttcc gccagaattc 2835661 ttttatccat attaatcccc cgctttcggt accaagaaaa ctatttcggt accaatatta 2835721 tacggcagaa atttatggaa atcaacaata tataaaaaaa cctctcctat tgggagaggt 2835781 ttaaaagaca ctgcggacca aaccgccgtc cgcccgaagt gccgcgccat tgatcgcaga 2835841 ggaaagcgga ctgcttaaaa atgtaacgaa gtgggcgatt tcttccggac ggatcagtct 2835901 ttgaataata gatgtcggcc ggttttcttt cataaaacgt gcctcagctt cttgaacagt 2835961 caggttttca ccaggataca gcgagttcag catggtttcc acaccctctg ttaaggtaga 2836021 gcccggcatg acggtgttga ctgtgacatt cgtgccggtt gccagctccg ccaaactgcg 2836081 ggaaatggac agctgcatcg tttttgtcgc actgtaatgg gccatttcct gtgacggcat 2836141 aatcgccgct tcactggcaa tgaaaatcac acgcccttct tttttctcta tcatgttatg 2836201 caaatacctg cgtgtcagcc ttacaccgct cataatattc acttcaaaaa aacgaaacca 2836261 ttcatcgtcg ggaatatcaa agtactccgc cggttcaaaa atccctaaat tgttgaccaa 2836321 aatatcaacc tctggatatg cctgaaacag ctcattgcag ccttcttctg ttcccaaatc 2836381 aaatgcagcc ggataaagaa ccgcttcagc atgttgtgtt ttcagttcat ctatcgtttg 2836441 attcactttc tcttcccggc gtccgttaat gatcactgcc gcaccttctt cagctaacga 2836501 agaggcaata gcttttccga tccctgatgt cgaaccggtc accagtgcgg tttttccttg 2836561 taaattcagc ttcattattc atccctccgt ttttgattcc tcttatttat tgacagaaat 2836621 ctgattggtg aaacatctgc tctgcaatca gtatgaaaca gctgggattg aaatggaagt 2836681 acgcactttt tggtgcctgt ggtttggaga aaaaataaag cagaacctct taagaggttc 2836741 tgctttattg tcagtatgta tggagacggt gggagtcgaa cccacgtcca gaaacatcga 2836801 ttacttaagc gtctacgagc gtagcctgca tatttatggt ttcactcatc ttcttgcctg 2836861 cgggcgggcc ttccgagagc tagtctgttc atctcttctt acgttctcag acgggaacgc 2836921 aagcgtagcc tacttggatg tgctcttcac agacacatag gcaatgtcag gaagagctcg 2836981 ctgcgcttat taggcagcta atgctacgtt ttggttaaaa ctgttagttt tgccagttat 2837041 atttaagtgc gtgtttacga gatcgcctct cggctcgcag ctcaagctcg atccatccct 2837101 gtcgaatccg taacgtcccc ttggtataag ggaaatacgg gagaaaatat caagctctca 2837161 ctcaaactgg ctatagtctt attataacat gatcacggct cttttcaatt gtcaaatcct 2837221 tcaaatgaat ggcgtcgtga tctgatcgtg aacacagtat agcacaggcc tgattttcga 2837281 atcaagcact atgcctttag aagccttttt gactgtctct gaacgctctt tcgatttccc 2837341 gcttcgcgtc cttgcgcttc agatcttccc gtttgtcata gttcttcttc ccttttccaa 2837401 ggccgagaag cactttggca aagccgtttt ttaaatacag cttcagcgga acgagagaat 2837461 agcctttttc ctttgttaac ccgatcagct tattaatctc cttgcggtgc attaacagct 2837521 ttcttgtccg gagcggatcg tggttatagc ggtttccctg ctcatatggg ctgacgtgca 2837581 tattgtggag aaacacttct ccccgttcga ttttggcgaa ggaatcctta aggtttacgc 2837641 ggccggcgcg aatcgatttg atttcggttc cttgcagaac gatgcctgtt tcataggttt 2837701 cttctataaa ataatcgtgg ttggctttct tattttgaga taatactttt cctgaccctt 2837761 ttggcatgcc agaacctcct ctctctaagg aaaaactgtc caccttttgc gatacgctct 2837821 attttaccaa atgtcacgta ccgctacaat gaaaagctgt ttccgaaaga aagcaaatag 2837881 agcgctgcgg ccctatttgc tggttgagct gctatttctt ctttttccgt ttctgtttcg 2837941 gagcattctg gaagccgcgt tttttctttt tcttcttcgg cttagtgaac cactcccctt 2838001 tttcctcaga cggagctgga gaaacaggtg tattggtgct ttgaacacgt tttctggcag 2838061 gctttccgcg ttttctgctc cggctgctgt ccaattctct cggacgccgc ggagtgcctt 2838121 tcatgccgac aatttcaaag tcgatattgc gctcatcttt attgacatcg acaaccttga 2838181 ctgtgatttc atccccgatg cggaagacgt tgcctgtccg ctcgccaatc attgcgaaat 2838241 gctgttcgtc aaagcggtag tagtcatctg tcataaagct gacatggacg agtccttcaa 2838301 ttgtattcgg cagctcgacg aacattccga agtttgtcac agagctgatc atgccgtcaa 2838361 actcttcacc gattttatca agcatgtatt ccgctttttt cagatcatcc gtctcacgct 2838421 cggcgtcaac tgcacggcgc tccatagatg atgtatgttc ggcgatatcc ggcaggcgtt 2838481 cagcccactt ttcctgtgtc gcttcatcga ccttgccgtt gatcaaatac gttcggatca 2838541 gacggtgaac gattaagtcc gggtaacggc ggatcggtga tgtgaaatgc gtatagaatt 2838601 ccgttgacag accgaagtgc cccaagcttt gcgggtcgta tttcgcctgt ttcatcgaac 2838661 ggagcataac agtagatata accgtttcct ctggtctgtc acgcacagcg tccagaatgc 2838721 tttgcagcgc gcgcggatga atattccccg ccgttccttt caccacatag ccaaatgtcg 2838781 tcacaaattc taaaaacttt tgcagctttt cagcattcgg ctcttcgtga atccggtata 2838841 taaacgggac attcatccaa tggaaatgct ccgcaactgt ttcgtttgct acaagcataa 2838901 attcttcaat cagcttctcg gcgacagagc gttctctgat cacaacgtct ttaaccgctc 2838961 cttcgtcatc aacaagcacc tttgcttctt tgaaatcaaa gtcaacggcg ccgcggtcca 2839021 tccgcttatc gcgcagaatt tgagccagac gctccatgtc tttgaacatc ggaacaagag 2839081 gctcgtattt ttgtttcagc tcttcatcat catcaacaag aattttattc acatctgaat 2839141 atgtcattct ttccgttgtt ttgatgacac tttggaagat ctcgtgctct gtcacctgtc 2839201 cctgactgtt aattgtcatt tcacaagaaa gcgtcaggcg gtcaaccttt ggatttaagg 2839261 agcagatgcc gtttgacaat ctgtgcggaa tcatcgggat gacacggtca accagataca 2839321 cacttgtccc tctttcaagc gcttctttgt caatcggcga gttttcggtt acgtaatggc 2839381 tgacatcagc tatgtgaacg ccaagcttgt agcttccatc atcaagcttc gtcacggtaa 2839441 ctgcatcatc caaatccttc gcatccgcac catcaatggt gacaatcacc tggtcacgga 2839501 gatcacggcg gtctttcaga tctttttcat caatcgtgtc aggcgtactt gatgcctgtt 2839561 ccatcgcgtc agctggaaat tctcccggca ggccgtgctt atgaatgacc gataaaatat 2839621 caatgcccgg gtcgtttttg tggccgagaa tggtttcaac ctcaccctct gcgttcatgc 2839681 ggccttcagg atagctcgtc agcttgacaa caaccttatg cccttccgca gctccatttt 2839741 tcccattttt cggaatgaag atgtcactcg tgattttttt gtcgtccgga atgacaaagc 2839801 cgaagtttct cgtttctgta tacgtgccga caacccgctg aatcgctctt tctaaaatcc 2839861 gtatgacggt tccttcctgc ctggagccgc ttgattgtga gttcagacgc accatgacga 2839921 tatcgccgtt cattgccgta tttagctcat taggcggaat aaacacatca cttaacgacg 2839981 tatcctcagg cagcaaaaag gcgaatcctt tcgcatgggc tgaaatcttt ccttttatta 2840041 aattcatctt ctccggaatg ccgtagcggt cgcttctcgt ccgtacgata agcccttttt 2840101 cttccaaggc gactaacgct ttgacgagct ctttaaactc ctcggcttcc gtaatattta 2840161 acatctcctc aagttcctga acggtcagag gtttgtacgc ctcttccttc ataaacgaga 2840221 gaagcttttc cataaatgct tctttttcca ttatccgacc tcctgttgat taccaatcga 2840281 gcttctctaa aaattcatac acatcctgat ggacgaggtc acgttctttg tcgagtgtaa 2840341 tgacatgccc tgattcctcg taccatttca gctgtttatc atcagtttcc acttcgttgt 2840401 aaataatatt ggcgctttcg gtattaatca tgtggtcatg acgggcctgc accacaaatg 2840461 tcggtgaata aatcatatcg acattattcc gcacatcagc aattaagtct tgcagcgcct 2840521 tgagggtatt catcggcgtt ttttcgaatt ctttcatttc ctcttcaatt tgctccgggc 2840581 ttttcccctc aaactttttg taattgcgag cgtatgaaag aacgccttga tacatgacct 2840641 cttcactctt aatatgcatc ggtgcgcaca ttgggacaat tccctttatg ggtacagtgt 2840701 aacccaattt cagcgaaaaa accccgccaa gcgacagtcc gcaggcagca atgctctcat 2840761 aaccttcaga ttttaaatat tcatagccat ccattacgtt tttccaccag tcttcgggcc 2840821 ccgtatgtac aagttcttca ggcgggacgc catgtccttc atattgaggc gcgtggcacg 2840881 tatagccgcg ttcattcaaa tatcgtccca gcatccttac atccgctgta tttcctgtaa 2840941 agccatgcag caaaagcacc gctttgtctc cgcctttaaa tgtaaatggt tttggtgtca 2841001 caactttcat gctcatgtct ccctttctat ctgcacgatc attttagttt tccacagttt 2841061 aatcagaaaa aaacgttttg aatatcatcc agaaacgtga aaaaggcctg acttcacatc 2841121 agaccttata caaacattgc cctataggat ataagcaagc gcaatcgtta acacgaaaaa 2841181 caagactgcc agcactaccg taatgcggtg caaaattaaa tcaagacctc ttgctttttg 2841241 tttcccgaag agctgctccg ctccgcctga aatcgcacca gataatccgg cacttttact 2841301 ggattgaagc aaaacgacaa taataagtgc aatgctgacg ataaccaata aggtaatcaa 2841361 aactgcgtgc atcccataca cctccagact cactggctac attacttcta ttttacatga 2841421 aaagggttgg catgtcacgc tgtatcagac gccaaaaggc cggataagac gttttatctt 2841481 ggttacccta ttcatatgaa aaggtcaaag gagaaaagcg atgccgctta tcagcataga 2841541 cagcaggaaa catctttttt atgaagaata tggacaggga atccctatca tttttatcca 2841601 cccgccgggc atgggacgaa aggtttttta ttatcagcgc cttctatcca agcatttcag 2841661 ggtgattttt ccggatttaa gtggccacgg tgatagtgat cacatcgatc agccagcgtc 2841721 tatttcctat tacgcaaacg agatcgcgca attcatggac gctttgcaca ttgataaagc 2841781 tgtgttattc gggtattctg ccggaggctt aatcgcgcag catatcggct tcacccgccc 2841841 ggacaaagtg tcacacctta ttctgtccgg cgcctacccc gctgttcata acgtaatcgg 2841901 ccagaagctg cacaaactgg gaatgtatct gcttgaaaaa aaccccggtt tgctcatgaa 2841961 aatcctcgct ggcagccaca caaaagacag acagcttcgc agcatattaa cagaccatat 2842021 gaaaaaagca gaccaggccc attggcatca gtattatctg gattcgcttg gctacaactg 2842081 cattgaacag ctgccccgcc tagaaatgcc aatgctgttt atgtatggcg gcctgcggga 2842141 ctggaccttt acaaacgcag gctattaccg aagatcgtgc agacatgccg aatttttcag 2842201 attggaatat cagggacatc aattgccgac aaaacaatgg aaaacgtgca atgagctggt 2842261 gacagggttt gtgctgacac atcattcata ggaatagaaa acgcttggct tccttgcgtt 2842321 ttttgttact ttattgactt ttgtcaacga aatcatagta aaaaagatcc tcaaatttca 2842381 aattaaaata gtgaagcatt ttaccaatca caagctgccc cggccttctt tctccattca 2842441 gcacgcggct cagtgtggcg ggtgagactc cgatttccag cgcaagctga ttaagggaat 2842501 aatcgttatt aaccatatac tgcaagacat aatcacgtct aatctgtatc ttttctactg 2842561 gcactttcct caccttccat tcctgaaaaa cttttttcta tacttttaca ttacggctta 2842621 tgttaacttt tgtcaataca tttccagtct acctattccc tttagtcaat aaacatacta 2842681 aaatatgagt aacagtgagg gacggggtga gatatatgga aagctttggc gaacaattac 2842741 gggcattgcg tgaagagaga aagttaacag tcaaccagct ggcgacttat tcaggcgtaa 2842801 gcgcggccgg catctccaga atcgaaaacg gaaaacgggg cgttcccaaa cctgccacca 2842861 tcaaaaaact ggcagaggcc ttaaaaattc cttatgaggg gcttatgtac aaggctggtt 2842921 acatcgaaga agtgcatgaa gccagggccc cttatgaaac gaagtgcaag ctgcttgaaa 2842981 aagcggaggc ctatgacctg aaaaaccttg cgcttcttga gaacgaaaag tggcaatatc 2843041 tcaataaaga agatttgctc atgctggatc attatttttc gtttatttca gatgaagcga 2843101 aaaaacggtc tgctgatgac tgactcttga tagaaatgtg aggcgataga ccatgtcacc 2843161 gttcggacag caattacggg agctgcgccg cgcccgcaaa ctgacagtga atcagcttgc 2843221 ggtgtactca ggcatcagct cggccaccat ttcaaaaatt gaaaacggca aacgcgggac 2843281 gccaaaaccc gccacgatta aaaaactggc agccgtcctg aaagtgccgt acgaaaacct 2843341 aatggccgcc gcaggccata ttcaggcctt tcctgaagaa atccgcgaag catctgaagg 2843401 ctatcaatcc gtttatgaaa tttaccagac ggctgtcaca cgcggagcgg agcacctccc 2843461 gattttcaat agtcaaaaat gggaacatct ctcaaagcag gatattgaaa atctcagcaa 2843521 atacttcgat tttttgtctt cagaagcaaa aaaacgcgcc tcttcctcat aatcccctgt 2843581 ttctctttct atattttatc aatcacgctt gcatgccctc cctcgttatt tgcgttataa 2843641 tagtgacaga cgaggtgaaa agtatgaacc aatcagaaat gtgtcctaga tttgaaaaag 2843701 cagtcgacat cttaagtaaa cgctgggtcg ctttaatcgt atttcagctc ttgaacgggt 2843761 cgcagcgatt tagcgaaatt gaagcagcac ttccaaatct aagcggcaga gttctgtcag 2843821 aacggctgaa agaacttgag cttgaaggag tagtgaagcg ggatgtcatc cctgaaactc 2843881 cggttcgcat cgaatattca ttgactgata aaggaaaggc actagcaccc atattaggtg 2843941 agatttctaa atgggcgact gaatggattg acccttcctt tcttgactaa ttgctaaaat 2844001 ggttctgatc tcaaagacga gaaaagaacc gttttttatt ttccaggtga aaaaaagata 2844061 tctcagccga tatatagtac atccacacat tacgttttta aaggagacca ctatatgcga 2844121 ctgacgattt cccgcaaatt cagcctggta tttttgacac tgatcctgat caatttactt 2844181 gtaggcggaa taggcgttct taatatgcag catatcattc aaaaaacaga tgaaatcaac 2844241 acaaaatgga ttgacggcat caaaggaatc acttcaatta attatgtaac cgagcacctg 2844301 tcttctaaag aaaaggactt tctgatttat acagacaaaa gtaaaatgga tacacttgat 2844361 caagaaatga atcaaatcat ggaagacatt aaccaaaagc tcgataacta cgaaaaaacg 2844421 atctccactg ataaagagca gaaactgttc gagcagcttc aaactaaagt gaatacctat 2844481 atggatattc atgcgcaaat tatcgaaagc ggccgcacga atgacatgga caaagcaaga 2844541 ggtttattgg ttcagactga ggccagcttt gaggatatga aaaaaacaat cactcagctt 2844601 gttgacttaa atcaagaagg cagcaacaca gcggtaaaag aaacgaaggc cgtctatcat 2844661 aaagggctca tttacactgc tttgcttgtg gcagcatcaa tcctcatcag cattttcatc 2844721 tggctttata tcacgcgaaa cattgtaaag cctatcattc gcatgaagga atctgccaat 2844781 catattgccg aaggcgattt gtcgaacgat atggaggccc tcaactcaaa agacgagctg 2844841 ggtgatctga atgaagcgct gcaaaaaatg gtagggaatc tgagagatat tgtcggatat 2844901 tctaaagaca tatcaagccg ggttctttct tcttcacagg tgcttgcaac cgcaacgaat 2844961 gaaacaagat ccggcagcaa acatattacc gagacgatga acgaaatggc tgagggctct 2845021 gaacagcagg cccaagacgc ggtgacgatt gccgaatcga tgaatgagtt taccgaaagc 2845081 attgataaag cctataatca cggcatcaca atcagcgata cgtctcaaaa cgttctcgaa 2845141 ctcgcggtaa gcgggaacga aaatatggct acgtcattac agcaaatgaa aaccatccat 2845201 catattgttg aagaagccgt gcataaagtg agatcactgg aacagcattc tcaggatatt 2845261 aacaagctcg ttcaggtcat caacgggatt gccgagcaga cgaatttgct gtcccttaac 2845321 gccgcgattg aagctgcccg cgctggagaa agcggcaaag gcttcgccgt tgtggcagag 2845381 gaggtcagaa agctggctga cggcgtttct gattccgtgc aggacattac ccggattgta 2845441 aacgggacac agcaggagat ccacactgtc attacgtact tggaaagcag ctttacagaa 2845501 gtcgaaaaag gaacggaaaa cctgacagac accggacagg ctatgcagca tatcaaacaa 2845561 tccgtcaccc atgttgcaga cagcattaag gaagtaacgg atggcttgaa gcagttaaca 2845621 aaccaatcga ttaccatcaa tcaatcgatt gaaaatatcg cttctgtatc cgaagagtct 2845681 gccgccggca ttgaagaaac attttcaatt accgagcaat ccgcccattc gatggatcaa 2845741 gtgcttctaa atgctgaaga gcttgagcag ctggccaatg agcttaatga gaagatgggt 2845801 cagtttacga tttaaagaga aaaaagaggc tggactccag cctctttttc tattctatgc 2845861 agctgattga acatgtttcg ccccggttct ttttttcttc accggactta atgcccgctc 2845921 cagccaagcc atgagcaaat ccgcccctac cgccatcacc gcagttggta tcgctccggc 2845981 tagaataatc gcagttccgt ttgttgcgtt tgagccgcgt acgatcatgt ccccaaggcc 2846041 tccggcaccg acaaatgtgc cgatcgctgt aattccgatg gcaatgacga gagccgtgcg 2846101 aaggcccgcc ataatgacag aaagtgcgag cgggagctca accattctga gcacttggaa 2846161 tttcgtcatg cccattgctt ttccagattc taagtaggca tgttcaatac tgataatgcc 2846221 tgtgtacgtg tttcgaataa tcggcagcag ggaatacaga aataatgata gaatcacggt 2846281 atttgcgccg agccccataa caagcattaa gacggccagc atagcgagcg ccgggattgt 2846341 ttgaataacg tttgttacgg caaacaccca ggctgacaaa cggcgaaaat gcgcgatgag 2846401 gattccggcc ggaaccccga cgacagcggc aaataaaacg ccgtaagccg acatgagaaa 2846461 gtggcggccg aattcatcca tgacgtaact gccattctgc gcgtaatacg tcattaactg 2846521 ttcaagcacg ttcattgacc tcttccccct ttcacgattc gaaatagcga tgtttttcta 2846581 aatattcctt ggcaacgaca gacggttctt tgagattgcc gtcgacttca tagttaagct 2846641 cctgcatcgt ggctgtgtcg atttttccga gcattttctt gatgatgcct tcaagttcag 2846701 gatgttcttt gagcaccttt tccggaacaa ccggagagca gtcgtacggc gggaaaaatt 2846761 gtttatcatc ctttagcatt ttgagaccat aggacttgat tcttccatcg gttgaatacg 2846821 caagcacaat gtccattttt ccgcttttca ccgcgtcgta cacaaggccg atctgcatcg 2846881 gatacgtgcc gccgaatgtc atgccgtagg ttttcgtaaa atcctgatag ccgtttcctt 2846941 tgagcttcat ccaatagtta tcaacgccca gctttaattg cggcgcccat tttttaacgt 2847001 ctgatacggt ctctaaatgg tattggtcgg ccagctcctt gctgactgta aaggcatatg 2847061 tattatcaaa cccgtaggag tcataccact ttaaatcata tcttttttta aactcccgct 2847121 gagtaagcgc cagcgctttg tccggatctt tttcaggttc cattctcaac gtgcctgtca 2847181 gcgcgtctcc cgtatatctt gtggccgcaa tgtcgatttc cccgttcatt aaagcctgct 2847241 gctgcaccgc gttggagcca agatttttaa tcgttgttgt tttgagatca gtatggtgtt 2847301 cgatcaactg gccaagcatg ctggcgatga tttctgattc gctcatgctt tgcgcgccga 2847361 ttttaatggt ctggtctgca gcagcgctga gaccaggaag cgaacagccg ctcagcgtca 2847421 gcgttgccgc aagtgctaaa cctatcatta atttgagata ttttcttttc atgagccgcc 2847481 tccttatgac aattccttca atctctgcat gccggcaggt gtcagttttc gttcagcaac 2847541 tgccagcaca taatcaatca caattgccaa tatcgtgaca ggtaccgcgc ccccgatgat 2847601 atattccggc tgatataaat tcagtccgat aaaaatgtaa tcacccaatc cgccgcctcc 2847661 gataaaggaa gcaagcgtgg cccagccgat taagtaaatc gtcgatgttc tgattcccgc 2847721 catgatcact ggtgcggcaa gcggcagctc caccaagcgg acttgttcag ccggcgtcat 2847781 tcctattcct ttaccagact cgagcagatt tttgttgacg ccgcgaatgc cggtatacgt 2847841 gttgcgaaga atcggcaata cggaatagaa aaacaaagcc acaatggccg gaaccttccc 2847901 tacaccaagg agcgggataa aaaaagcgag gatggccaga ctcggcagcg tctgaatgat 2847961 attgacaatg ccgataatgg tgccggctcc ttttttcatt ctggtaagca caaccccgag 2848021 ggggacggca accagcacac ctaagatcac agcaatgagc gatatcgtaa tatgctcgta 2848081 tgttttataa agaagctctc ccccattggt ttgcaaaaat tgaacaatat gatgcatgac 2848141 ttatcgcccc tccctatgac aatgctgcga gctgcttttc ttctccccag agggagtcat 2848201 acacgatgtc gaccagactt gccctcgtca caattccgat caggcgtcgg tcttcatcca 2848261 caacgggaac atatttgaca ccccgtttta aaattttgcg gaccgtgtcg cgcagcagtg 2848321 tgccgcccag tactgtgtat atatcttcat gtaaaacttc actgacgaga ttggcctttt 2848381 tccggcattg atcaatgatt tcaacatcga catagccttg cagaacgcgc tcgtcattga 2848441 cgaccagcaa tgaatcgacc cgttcctgcc tcatcagctg aatggcctca gaaagcgttt 2848501 tatccgcggt gatcgttaca ggctgtgtgt tcataatctg gtcaacccgt tcaacatccg 2848561 ggctggatga ctgaatcagc cgctccttgc cgataaattc ctcaacaaat tcgtctgccg 2848621 gatttcttaa aatgtcatcg ggcgttccaa cttgaacgat ttctcccgct tttaaaatca 2848681 caatccggtc tgccagctta atcgcttcat ccatatcgtg ggtaacaaat acgatggttt 2848741 tatgtaaggt tttttgcagt tttttaaatt cttcctggag ggaatccctc gtaatcgggt 2848801 cgagtgcccc aaacggttca tccattaaga taagcggcgg ctccgcggca agtgcccgta 2848861 atacaccaat tcgctgctgc tgccccccgc ttaattcatg agggtaacgg tctacatatt 2848921 ctggccccat atcgaccaat tttaaaagct cacgcgcccg ctctttccgc tgctgctccg 2848981 gccatttcag cagttttggg acgagtgaga tattctgctg aatggtcata tggggaaaca 2849041 ggccgatctg ctgaatcaca tagccaattt tgcgcctgag ctctacagga tcctggtcca 2849101 tgatgttttc gccgtcaatg aaaatcttcc cggcggaagg ctcaattaat cggttaatca 2849161 ttttcattgt tgtcgttttt ccgcagccgc tcggcccgat aaagcagata aattcgcctt 2849221 ttgcaatctt aagatttacg ttgttcacgg cttttttgcc gcccttgtat gttttcgaga 2849281 cattttctaa tgtcagcaaa catcgcacct ccaaaattaa gtttattcaa tttgttcagt 2849341 ttaaatttaa tttttcagac aattgaatgc ttcccattat agaataaagt ttataaaata 2849401 aaaagtttac aatttgttca tattatttat aaagtatgtg taaacgctga tttacccgca 2849461 ttgacgtgtg ttgatctcct tattgctcca atttcctgcc aaattctctt ttgacagcat 2849521 tttcgccgta tcaaaaatgt ggtatattga catcggaatt gttagctgaa aggatgaaac 2849581 cgttggagaa agatccgtta acgatcattg aacaagccga ggaccatttt atagaaagaa 2849641 tcgcggaaaa catgcatgca tttggaatgc cctctaccgt cggacgagtg ctgggcatta 2849701 tttatatgaa tcgaaaaccg atgacgctta cggaattatc tgaggccacc ggcatgagta 2849761 aaacacgtat gagccaggta gtgcgggaaa tgcttgatgc caacattgcc gagaaggtat 2849821 tcgaaaaagg cgtgcgaaaa gatttatatg aggttgagca ggactactat caaacattta 2849881 tcacgctgtt ttcagccacc tggagcaaag tcgtcagcaa aaacaaaatg atgcataaaa 2849941 aactcaatcg ggagctgctt agcgtgttgg atgaagagct tactcctgaa gcggaagaaa 2850001 aagtgaatga gctgctgaag gaattaaagg aatggctcga ttattataat tggctcagcc 2850061 gtttgattga gttttttgag agcgaagaca tttttaaata tgtgccgaag ccgtaaaaag 2850121 ttcccaaatt caattctggg aactttttta agtccaatcc aaatggttga atatcaaact 2850181 tcgagctccc aacgctggaa aatatgttta acagatacta acacatgttg tttatttaaa 2850241 aaaaccacct ctgttgtatt taaatagagg tggtttttct atcagctata ataaaatttc 2850301 cttttttctt tttaatcggg cttaatgctc gttcaagcca gcccatgacc aaatcggcaa 2850361 tcaccgccat cagagctgtg gggatcgctc ccgctaatat aatcgcggtt ccgtttgtgg 2850421 cgtttgatcc tctgacgatg atgtccccga gaccgccagc accgacaaat gtcccgatgg 2850481 ccgtaatgcc gatcgcaatg acaagcgcgg tgcgcaggcc ggccattatg acagaaagcg 2850541 caagcggaag ctcgaccatc cgcagcactt gaaattttgt catccccatt gcttttcccg 2850601 attcaagata ggcgtgctca atactgataa tccctgtata cgtatttctg ataatcggca 2850661 gaagagaata cagaaataat gacaatatca ccgtattagc gcccagcccc atgacaagca 2850721 tcagcacggc gagcatggcg agagccggga tggtctgaat gacattcgtg accgcaaaaa 2850781 cccatccgct taatcttctg tatctggcta tcaggatgcc gagcggaatt ccaacaatgg 2850841 cggcaaataa aacgccatac accgacatca gaaaatggcg gtaaaattcc tgcagcacgt 2850901 aaccgccgtt ttgcgaatag tatgtgccaa gctgctgtag tacttccata tgatccacct 2850961 cttttcttag tcaaaataat gatgtttctc taaaaattcc tttgctacga cagacggctc 2851021 cttcagcttg ccatccacct cataattaag ttcctgcatc gtttccgtgt cgatttgccc 2851081 aatcagctta ttgatcacac cttcaagttc cggatgctcc ttaagcacct tttccggaat 2851141 caccggtgaa cagtcatacg gcggaaagaa acgcttatcg tcttttaaga ttttcagatc 2851201 atatgcttta atccgtccat ccgttgaata agccaaaacc gcatccattt tcccgttttt 2851261 gactgcgtca tagactagcc cgatctgcat tggataagtt gtgccgaact caaagccata 2851321 tgtgctgaca aagcctttat acccgtcgcc ttttcgtttc agccaagcat tgtcgacgcc 2851381 taatttatat tgggaagcat ttttcttcag gtcagacacg gtgttaatat gctccttttc 2851441 cgcaaacttt tttgttacgg tgaaggcata tgtgttatca aagccgtagg aatcaaacca 2851501 tttataagaa aagcgctttt gaaactcgtt ctgcacaatg ttcagcgctt ttttcggatc 2851561 tttctccgct tccttgccga gggtgcttgt taaatctgtt ccggaatagc gcgtggctga 2851621 aatatcaatg tcaccgccca gcatcgcttg gtgctgaaca tagtttgagc cgaggttttt 2851681 cactaaagca gtattcaaat ctgtatcatg ttcaataagc tgcgcgatca tattcgctac 2851741 aatttctgat tctgtcatgc tctgcgcccc gattttgatc gtatcgtcag aagcgccgcc 2851801 tagacccggc agagagcagc cgcctagcag catgacaaag acgagagcaa acgcgccaag 2851861 ccatttgatt tttgtcattt tcaacagtgc caactcctta cgatacttcc ttcatccctt 2851921 gcaagccttt cggcgtcacc tttcgttctg tcacagccag aacataatca ataataattg 2851981 ccagaattgt gacaggcacg gcaccgccaa tgatatattc aggctggtat aggttcagtc 2852041 cgataaaaat atagtccccg aggccgcctc ccccgataaa cgacgcaagt gtcgcccagc 2852101 caattaggta gatcgttgat gtgcggatcc ccgccatgat gatgggaatc gccagcggga 2852161 tttcaacgag ccgaatctgc tcccagccgg tcatgccaat tcctttcccc gattccagga 2852221 ggtttttatt tacaccttta atgccggtat acgtattgcg caggatcggc agtaccgaat 2852281 agaaaaataa agcgacaatc gcaggcactt ttcctacgcc gagaagcgga ataaaaaagg 2852341 ctaaaatcgc cagactcggc agggtttgca caatgtttac gaaaccgata accgcacctg 2852401 cgcctttttt cattctggta agagcaacgc cgagcggcac tgcaacgata atgcccaata 2852461 caacggctat gagtgaaata tataaatgct ctcctgtttt atacagcagc tctccgccgt 2852521 tcgtttgcaa aaaagtcatc atttgattca tcttaaaaga gctcctcccc tggtcagatc 2852581 gtcatgagct ggttttcctc gtcgccccaa atggaatcgt atacgatatc aacgaggctc 2852641 gctcttgtca caatccctgc taaatggttc tgttcatcga ccaccggaac atacttgatc 2852701 ccctgcttca aaatttttcg gactgtatcg cgaagaagcg cccctttttg aacggtatat 2852761 atatctgaac ggtatacatc gccaacgatg ctcgcttttt tgcggttttg atcaatcatt 2852821 tccacatcaa catagccctt cagcacgttt tgccggtcca caacgagcag cgagtcaaca 2852881 cgtttttctc tcatcagctg aatcgcctga gaaagcgttt tgtccgcaga taccgtcacc 2852941 ggcgttctgt tcatcatttg ctctacccgc tcgatatccg gtcttgactg aatcaggcgc 2853001 tctttcccga taaattcttc aacaaactca tttgccgggt ttcgaagaat ctcatcaggt 2853061 gtgccgactt gaacgatttc tcccgctttt aatatcacaa tcctgtcagc aagcttaatc 2853121 gcttcatcca tatcgtgggt tacaaacaca atcgttttgt ttaaggttct ctgcagtttt 2853181 ttgaattctt cctgaaggga atcacgcgta atcggatcaa gcgctccgaa cggttcatcc 2853241 attaaaatga gagggggttc cgctgccagg gcgcgcagca cgccgattct ctgctgctgt 2853301 ccgccgctga gctcatgcgg ataacggtct aaatactctg ggcccatatc cacaagcttt 2853361 aacagctcgc gcgcccgttc tttccgtttt tcctcaggcc atttcagcag ctttggtacg 2853421 agtgagatgt tctgctggat ggtcatatgg gggaacaaac caatctgctg tatcacatag 2853481 ccgatttttc tcctcagctc aaccgggtcc tgttccataa tattttctcc gtcgataaag 2853541 atccttccag acgatggttc tatcagtctg ttgatcatct tcatcgtcgt cgtttttccg 2853601 cagccgctcg ggccgataaa acagataaat tcaccttttg caatatctaa atcaatgctg 2853661 ttcacagctt ttttgccgcc tttatatact tttgacactt gttccaattt cagcaatccg 2853721 tgcacctccg caggtttcct ttaaattttc tgaaaagtat aatccttatt atagtttgaa 2853781 ctttgtaaaa taaaaagttt acaatgtgtt gaaattatat gttatttata gattatttat 2853841 tgttatgacc gagacggaaa gggtgttctt acaattactc cggatacctc ccacttcctc 2853901 tgcattcagc tattttcaac accaggaaga aatatgatat attgacacca tcaattgcca 2853961 tttgaaggga tgatcagctg tgaaaaaaac cgctctcgac atcattgaac atgctgaaga 2854021 gcatctcatt gagaagattg ccgaaaatat gcatacgttt ggaatgcctt caactgtcgg 2854081 acgtgtgctc ggaattattt atatgaatcg aaaaccaatg accttaagcg agctctctga 2854141 ggcaacgggc atgagcaaaa cacggatgag ccaggttgtc cgggaaatga tcgatgccaa 2854201 tatcgccgaa aaggtgtttg aaaaaggcgt acgaaaagac ctttatgacg tcgagcagga 2854261 ttattatcaa accttcattt ctttatttgc ggcgaattgg acaaaggtcg tgagcaaaaa 2854321 caaagtgctg tataaaaaat taaaccggga gctgagtgat cttttacaaa gggacgggct 2854381 taccccggaa gcggaagaga aagtcaatca gctgctgaat gaattaaaag aatggcttca 2854441 ttactatgat tggctgagca ggttgattga attttttgag agtgaggaag tctttcggta 2854501 tgtgccgaaa acaaaagaat gcagctctct aaaataagag agctgctttt tgcatcatga 2854561 agttaagacc ggaaacatgc ctttcagccc ggcaccaatc atcccgaccg caaccacggc 2854621 taagattaat cccatcagtc tggtaatcac attcatctcg gtttttccga gtttgctgct 2854681 gataaaagca gaatagtgga aaaagagaaa ggtcagggca ataacggcgg ctatgccgat 2854741 catgacagcc gcataatgac caatgccgct atgtccggcg gaaaggctca tcactgttgc 2854801 aatcgttccg ggcccagcaa tgatcggaat ggataaaggt gtgactgata tatccgcttt 2854861 ttccttgctt tccttatgtt catcatggtg aagagattgc acgtgcgatt ctttcgcatt 2854921 caatagatta taggcaatgc cgaaaatgaa tatgccgccc gccactcgga gcgcgtgaat 2854981 gttgatatca aacagtttaa agataagatg accgaaaacc aaaaaagctg cgagaataaa 2855041 aaaggataaa atagctgcct tccgggcaat cgcttttctt tccgctgcag tatagccttc 2855101 tgtcagcgtc agaaatatcg gtacgtttcc gatcggattc gatactgcga ataaagaaat 2855161 gaagacgtga acgataaatg agaacatcat atacctcctt gttgatagtc tctgcacagg 2855221 aaatagaatg attctccacc cttttacccg gaggcgattt cccggtaaac ctttatagcc 2855281 tgtcagaaac gcgccatgct acaatgaagt gacaaattga ataggaagga cgtatacaga 2855341 tgttcaaaaa aattgcggca gatgccttgg gcttatctga tatcggaaaa attatcgaac 2855401 ctcaggacta tgacaaaaca gacgcagatg actatgtcat gcatgaagat aatgagaaaa 2855461 tttatttctt gattaaaaca aaagcagacg agtattgctt tacgaacctg gccctgatcc 2855521 atgtggacgg cgaacgcgcc acttcctcaa aacgaacgtt gaaacgctat ccttattcgc 2855581 aatataaaat ctctgacgtt tttcttgaaa ctgccggaaa agtggatttg gatgttgaaa 2855641 ttaagttcaa gctgggcggt gaacaattcg acattgatgt ccacaaagac cagattgaaa 2855701 agttaaaaga cctttataaa gcactgcttc gcatcgctga aacaacctat gaaaatgaca 2855761 ttttaatcaa tcaagcggag caaagcttag ataaagcagt gacgattctt caccataccc 2855821 gccctgagca cgtcaatatt gaaacgcaat acaaagagct gaccgaattc ggattcactt 2855881 ggctgacatc cgttcgctcg cagtatcata ttaaggattt tggggatgta tttgagaaat 2855941 atattaataa ctagataaaa aaagacacag ctgctatcgt gctcgtgtct ttttttgtat 2856001 gaatattgat tactttacaa cttttttctt ttataataaa actattagtc tattttccct 2856061 atattacaga taaaggagtt attttatgta ttgtcctcaa tgcggccatc aaacagatgg 2856121 cggaaatttt tgtgagaaat gcggatcacc gctccccggt caatcaggcc accagcatgc 2856181 agctcaaact ggagccgctg caaagcaagc agcaaaacag ttcggttcat ttgtcttatc 2856241 cgtcctgaaa cgcccttatc aggaatgtaa agcaacaggc ggagaacagc tgatcagcgc 2856301 aatcattacg atggttcttt tcagtttgct gacccctttg atgttttata ttcttttttc 2856361 agacggtccc ggaagcgtaa gctttacagc aatcttctta gagccaacca tttattttat 2856421 tttatttcta tttggcctgc atgcatgcat ctttttcgcc ctgaaaatcg cgggaaacca 2856481 agtgtctttc aaggattcat tctcaagatt cggagcattt cttattcctt ttacggctat 2856541 tttgattctt gcccttttct tctttttatt acatacagac atttgcttta ccatattagc 2856601 cgttggttta atcggtgcat tcttcgccat tcctcctgcg atgctgagca gttaccagca 2856661 ttcatataaa gggaaggttg atttcattta ctcaacgatt gtgatttatc tgatcatctg 2856721 cgttacattt cagcttatta tcgaacacta tgtcaaagaa attttccgtt atatgctctt 2856781 ttaaaaacaa ccccatcacc tgctggtgat ggggttgttt tattgaatag acgttaagta 2856841 aattcttccg ttcttcacta cgccggtgta ggtccagtta tatgttctga gctttggact 2856901 gccgcctgat tttgtgatat agaattcttc atacgtctta atcgtgatag ccgacccatt 2856961 ttggctccag cttttcactt catagttatt aaagtcttct gttgtcccct ctttatttaa 2857021 tttcgacacg agatgctgct ggtcggaata aagggaactg cctttttcaa ggctgtcttc 2857081 catcagtgag aaattatttt gattcacggc atctgcctga ctttgcagat aactgcccat 2857141 aaataatgtc acttgttcat ctgtaacatc gccgcttgca gagctttcac tgcctttgtt 2857201 tttcgagcca gcccaggcgg aagtgtatgt ctctggttta tcatttttga ttttctttat 2857261 atttgtgcct gcagattcga atgttgattc tgcatcttcg aaaatccact ttttctgttt 2857321 tttatcatat gaaagaagat attcataact cggactgtcg tcagtcattt cagactttgt 2857381 atagtcgtta tacgaagaag actggtgaag ttcttttcct gttaccgata cctgccacgt 2857441 tccgtcgttt ttctgagaga gggcaaatgt gtccaggtca aaatcagttt ccaagtatct 2857501 atcttttaag tatgaatccg cgcttttcat agaatcgacg gtgtccttcg tctccgcctt 2857561 ccaattggca cttgcctctg tcatctgggc tgtattccca tcagatagag ctttggagta 2857621 ttgttttgtt gttttgacaa ttgtgttcat aatctgttcc tgtgtatctt gatcaggaat 2857681 taacgttaac tccatttctt tatcatcgat cggaacgccg gcagtttttg tttttcccca 2857741 cggaaattct gcctcgactg aagctgtcat tgatccatct gtcagcagcg gaccatatgt 2857801 tacggatttg aacggatctt tatgaattga tttaccgtta atcagcaaat ctcccttccc 2857861 gctcttgatg tcattcgcta agctgaatgt cacatcgtct gcttccaatg agagatcaac 2857921 acgaaagctg ctatcgccaa tcgcctgaat gtcttccttt ttcacaaggt caacgacatc 2857981 gtttttcagt ttggctgaga ctgtatattc gccgggaatg tacggaccaa gggtttgtgc 2858041 ttgatctgct ttctttacag atccggcttc ctctttattg acatatagat cggtattttt 2858101 ataattgctg ctcacttcaa aataaacagg tgctaccttt aagtcataat ggtcaaatac 2858161 cagcaggctt ttcccgtctt tttccgcata tacgatatcc ttctgggctg tttcatcacg 2858221 cagcgatgca aaaagttcat cttttttgtc tggatgatcc ttcaaatatg taagaaacgg 2858281 ttttacatta tttttagtga gtttaagatt gtcatttacc ggtgtaagca gagtcgcgat 2858341 ttggtcctga tccccatcat ttacggcctg ttcaaacttg tctactaacc tatcctttga 2858401 agtaaaatac gctccggttt tatatgcggc gaataatata acgcacgccg cggcaatgct 2858461 gctccataaa atgatggttt tcttagggat cggttttcgc ggagcctgcc tcgtttctgc 2858521 agtgctagct gtttcttgat ttgcctgttt gctgccccct ccgatcgggg tgccgcattg 2858581 tttacaaaac ttggctcctt cattattctg ggagccgcaa ttcttacaaa ataacatgac 2858641 tttcctccta ttctactaat ttgataacat ttactgcttt tcatatttta taataaaaca 2858701 gaatgaaatt gggaacgaat gaaaaaatta aatgtctatc agactaaaaa ggtggaatga 2858761 atatgcaaaa gctcaggatt gaattaggag aagaaacaaa tgacgaatta tatgatctat 2858821 tgctgctcgc cgatccatcg aaagacattg tagatgaata tcttgagagg ggagaatgtt 2858881 acacagcttg ggccggtgat gagcttgcag gggtttatgt attgctaaaa acaaggccgc 2858941 aaacagttga aattgtaaat attgcggtaa aagaatctct tcagaagaaa ggctttggca 2859001 aacagcttgt acttgacgcc atcgaaaaag cgaagaagct gggggcggac acgattgaaa 2859061 tcggaacggg gaattcgagc attcatcagc tttccctcta tcaaaaatgc ggattccgca 2859121 ttcaggcgat cgaccacgat ttctttctca gacattatga tgaggacatt tttgaaaacg 2859181 ggattcaatg ccgcgatatg gtaaggcttt atttggatct ctgaaagcat aaaaaagccg 2859241 ccgagagaaa atcccggcgg tctttttatt acttgtttaa gttgtagaaa gagttgatac 2859301 cgtggtattg agcagtttca gccaactgat cttcgatgcg aagaagctgg ttgtatttcg 2859361 caacacggtc cgtacgagac ggagcacctg ttttgatttg tcctgcgttt gttgccacag 2859421 cgatgtcagc gattgtgctg tcttcagttt caccagaacg gtgagagata acagctgtgt 2859481 agcctgcgcg tttcgccatt tcgatcgcat cgaatgtttc agtcaatgta ccgatttggt 2859541 ttactttgat caggatagag ttgcctacgc cgtttttaat accttcagaa agttttttcg 2859601 tgtttgtaac gaagaggtcg tcaccaacaa gctgaacttt tttgccaaga cgctcagtaa 2859661 gaagcttgtg gccttcccag tcgttttcgt caagtccgtc ttcgatcgag atgattgggt 2859721 atttagaaac aagctcttca taccagtcaa ccatttcagc agatgttttc acaacgcctt 2859781 cgccagacag atggtatttg ccgtcttctt tgttgtagaa ctcagaagat gcagcatcca 2859841 tagcaagttt aacttcttcg ccaggtttga agccggcttt ttcgattgct tcaacgattg 2859901 tttgaagcgc ttcttcgtta gaaccaaggt ttggagcgaa tccgccttcg tcacctacag 2859961 cagtgtttaa gccttttgcg cttaatactg atttcaggct gtggaagatt tgagcgccca 2860021 tgcgaagtgc ttcacggaag ttaggagcac ctacaggcat gatcatgaat tcttgaatat 2860081 ccacgttgtt atcagcatgc tctccgccgt ttacgatgtt catcatcggt acaggaagcg 2860141 tttttgagtt gaatcctcca aggtattggt aaagaggaat ctgtaagaaa tcagcagcag 2860201 cacgcgcaca agccatagat acgccaagga ttgcgttcgc accaagtttg cctttgtttt 2860261 cagtaccgtc aagctcgatt aaaagctgat cgattgcgtt ttgttcagtt acatcaaagc 2860321 caagaagctc tggagcaatg atttcgttta cgttgttaac agctgttaac acgccttttc 2860381 caaggtaacg gtctttgtcg ccgtcacgaa gctcaaccgc ttcgtattca cctgtagaag 2860441 ctccgcttgg cactaatgcg cggccgaaag ctcctgtttc tgtatatact tcaacttcaa 2860501 ctgttgggtt gccgcgggag tctaatactt cgcgtgcata aacatcaaca atgtatggca 2860561 tgagttttgt ctctcctttt gattttcaaa ttatttttga attaaagatg ttcctgtcat 2860621 ttctttcggt ttttcaacac caagaaggtc taataacgtt ggtgcaaggt cgcctaggat 2860681 tccgccttca cgcagcgtaa tgccttcttt cgttacaatc acagggactg ggtttgttgt 2860741 atgcgcagtg tgcggttcgc ctgattctgt aatcagaatg tcagcattac cgtgatcagc 2860801 ggtaatgata gcgtgtccgc ctttagcaag gatcgcgtca acgacttcgc ccaagcattc 2860861 gtccactgct tcaattgctt taattgttgg ttcaaccatt ccggagtggc cgaccatatc 2860921 agggtttgcg aagttaagaa tgatcgcgtc atgcttgtca gcttcaattt ctttgacaag 2860981 cgcgtctttc acttcatacg cactcatctc aggcttcaag tcatacgttg caactttagg 2861041 cgagttgatg agaatacgct cttcacccgg gaattcagct tcacggccgc cgctcataaa 2861101 gaacgtgacg tgcggatact tttcagtttc tgcaattcga agctgtttta acccgtgctg 2861161 agataatact tctccgactg tgttatcaag atttatcggt ttaaacgcta catagccgtc 2861221 aactgtttca ctgaagtgag tcaggcagac gaaatacagg ttctttggat aattctcgcc 2861281 gcggtcgaag tcacggaagt ctttgtttgt gaacgtgttg gaaatctgga tggcgcggtc 2861341 cggtctgaaa ttatagaaaa tcacagaatc gccgtcttgg attttcgcaa caggctcacc 2861401 gttttctttt gtgatgacag atggaatcac gaattcatcg tagataccat ttgcatatga 2861461 atcatcaaca acatccaggg cgctgcggta agatgggcct tcgccgtacg ccattgcgcg 2861521 gtacgctttt tctacacggt cccagcgttt gtcgcggtcc atagagtagt aacgtccgga 2861581 aatgctggcg atttcaccta caccgatttc cttgatttga tcgttcaact ggttgatgta 2861641 cgttttcgct gtctgcggac ctacatcacg gccgtcaagg aagccatgga tataaacctt 2861701 tgtcagccct tcttttttcg caagctttaa cagtgcgaat aaatgattga tatggctgtg 2861761 cacgcctccg tcagataaaa gaccgaacag gtgcaaggct ttgttgtttt ctttcgcgtt 2861821 gctgatcgcg tcaaggaatg tttgattgcg ttcgaactct ccttcacgaa tggcaacatt 2861881 tacgcgtgtt aagctttggt acacaatacg tcccgcaccg atatttaagt gacctacttc 2861941 ggagttcccc atttgccctt caggaagacc tacagcctcg cctgaagcag tcaaagtttg 2862001 atgaggatac tggttccaat agcggtcaaa attcggtttt ttcgctaaag cgactgcgtt 2862061 ccctactgtt tcgttacgta atccgaaccc atcaagaatg atgagtgcag ctggtttttt 2862121 actcatattg accttcctcc aataattgaa cgaatgactg tggctcaagg ctcgcgccgc 2862181 cgaccaaagc accgtcaata tcggactctg ccatatattc tttaatgttt gcaggcttta 2862241 cgcttccgcc atattggatg cgaagcttgt ctgcagcttc ttggctgaag ctttcagcga 2862301 cggttttacg gatatgcgca cacacgtcat tcgcatcttt cgctgtagaa gatttgcctg 2862361 ttccgattgc ccagattggc tcatacgcaa taacagaagc agcaacttgt tcttcagaaa 2862421 gaccagcaag gccttttttc acttggtcag caacaagatc atttgttttg ccggcttcac 2862481 gctcttcaag cgtttcacct acacagatga tcggcacaat gccgtgtttg aaagctgcgt 2862541 gtgctttttt gttaactgtt tcatcagttt cagcgaacat ttcacggcgc tcagagtggc 2862601 cgatgacgca gtagtcaacg ccaaggtctt tcagagcaac cgggctgatt tcgcctgtga 2862661 acgcgccgct ttcttcgaag tgcatgtttt gagcgccgac ttttaggtca gtgcctttca 2862721 cagcagaagc aagcttttct aagaaaagcg ctggcgcgca aacaacagct tcagctttgt 2862781 ctgctgctgg aatggaagat ttcacttctt caacgaagct gacagcttcg ccgagtgttt 2862841 tgttcatttt ccagttaccg gcgataattg gttttctcat ctgttccact tccttatagc 2862901 agttttgaga ttatttatcg ttcagtgcag ctacccctgg aagctctttg ccttccataa 2862961 actcaaggga tgcgccgccg cctgttgaga tgtggctcat tttgtcagca aggccgaatt 2863021 tttcaaccgc tgccgcagag tctcctccgc cgatgacaga gtatgtatct ttcgcctctg 2863081 ccaatgcttc cgcaaccgct tttgttcctt gagcgaacaa gtcgatttcg aatacgccca 2863141 ttggtccgtt ccacacgaca agtttgctgt ttttgatgac gtcagcatac gtttcgcgtg 2863201 ttttcgtacc aatgtcgatt gcttctaaat cactagggat ttcagagatc ggcacaattt 2863261 tcacgtttgc atcgttagag aaatcatctg caacgagtac atcttcaggc atgtagaagt 2863321 taacgccttt ttctttagcg cggtccataa atgatttcgc aagctcgatt ttatcctctt 2863381 caagaagaga tttcccgact tcatagccaa gcgcttttac gaaagtataa gcaagacctc 2863441 cgccgatgat caggttgtct actttatcaa gaagactttc gattacaccg attttgtctt 2863501 ttactttcgc tccgccgatg atcgctgtga acgggcggtc aggattggaa accgcttttc 2863561 caagtacatc aagctctttt tccattaaga aacctgcaac tgctggcaga tgctcggcaa 2863621 ttccagctgt agatgcgtga gcacggtggg cagcaccgaa tgcgtcattt acatatacat 2863681 ctgcaagctc agcaaatgct tttgcaagct caggatcatt tttctcttca ccaggataga 2863741 aacgtacgtt ttccaataca agaacgtctc cgtccttcat ctcagaaatt tgtgctttta 2863801 cagcatcgcc gtatgcttca tccgcttttt tcacttcttt gccaagcagt tcgccgagac 2863861 gtgcagcgac aggagttaaa cgaagctcct caaccacttc gcctttcggg cggcctaagt 2863921 ggctcgcaag aaggactttt gcgccttggt ctgcaaggtg tttgattgtt ggaagcgcag 2863981 cacggatacg tgtatcgtct gttacttccc cgtctttcat tggaacgtta aagtcaacgc 2864041 ggcagaatac aactttgcct tttacgtcga tgtctttgag agttttttta ttcatgccta 2864101 ggagatcctc cttcaaaatg gtttgcatac agcacgaaaa acgtgaaacc gtctgttcaa 2864161 gcgataactc cgctagggca gatcgcagtc tttttcggca cagggcagtt cgtctaaaag 2864221 ccagggcagc ggccttaggc gaaagcgccg gcaaagctgc ttaaaacgcg gtcgtttctc 2864281 tatcacagag cgttttctga aagccggtct tcatggaaaa agggaaaggg agtccgtccc 2864341 cttcccttgt ccgctttcat tatagcgctt ctattcgaaa gaaccaagtc aggtcctttt 2864401 tcagctataa attaaagacc tttttttgcg atgtaagctg caaggtcaac aacgcggtta 2864461 gagtagccgc tttcgttatc gtaccaagag attactttta ccatgctgcc ttccataacc 2864521 attgtagaaa gagcatcgat tgtagaagag tttttgtttc cgttgtagtc gccagaaact 2864581 aatggctctt cgctgtagcc aaggattcct ttaaggtcgc cttcagccgc ttctttaaga 2864641 gctgcgttta cttcttcagc tgttacttct tggttcagtt cagcaaccaa gtcaactaga 2864701 gaaacgtttg gagttggaac acgcattgct ccaccgttca gtttgccttt tagttcagga 2864761 agaactagag aaactgcttt agcagcacca gttgatgttg ggatgatgtt ttcagctgct 2864821 gcacgcgcac gacggtagtc tttgtgcgga agatcaagga tttgctgatc gtttgtgtaa 2864881 gagtgaacag ttgtcatcat accgcgtttg atgccgaatt tatcgttaag tacttttgca 2864941 aacggcgcaa ggcagtttgt tgtgcaagat gcgttagaga taacatcgtg gttagccgca 2865001 tcgtatttat cttcgttaac acccataacg attgtgatat cttcttcgtt agcaggagca 2865061 gagatgatta cttttttcgc gccagcttct aagtgtttcg cagcgtctgc gcgttttgtg 2865121 aagaaaccag tagattcaac tacgatttca acgccttgtt tgccccagct aagtttagca 2865181 ggatcgcgtt ctgcagaaac ttcaattgtt ttgccgttaa caacaaggtt gttaccgtca 2865241 actgaaactt cagcgtctaa ttttccgtgt acagaatcat attgtaaaag gtgagccagc 2865301 atgttagcat ctgttaaatc gttaaccgct actacctcaa cttcaggatt gtttaatgct 2865361 gcgcggaata cgttacgtcc aatacgacca aaaccgttaa taccgacttt tactgccatg 2865421 attgtttcct cctttaaata agtgagagat atttatattg agggattatt catcccttaa 2865481 taacttcttt gcggctcctt cgtctgtgac gagaaccgtg ttgcgtggct ttttaaagta 2865541 agcctcgatc gcttcggctt ttgatgatcc gcccgctacc gcaataatat cggggatggc 2865601 gtctatgtca tccagctgca ttccgacaga atgcactttg tgaaccactt cgccgtccgc 2865661 gttaaaatag tagccgaacg cttccgtcac cgcgtcgtta tcatctattt tctttaaatc 2865721 ttctaaaggc gtgtttctgc gctgagccat agttttagct tcgccgattc cgtgaaccag 2865781 catactcgct gatttaatgg tgttcagcac ctctttgaca gaaggctctt caataataga 2865841 tgaataggcg ccttgtgaca gctgtcccgg aacaaacaaa agccggtaag tgcctgaagc 2865901 cttctccgcc atatgcgcgc atatggtgtt cgcctggttt ttcacgtctt cgcctaaacc 2865961 gcctcttgca ggcacaaaca aaagctcgcg gtttttagaa tccggcgtca tcatttcggc 2866021 gacagcttca attgtcgtac cgccagttac agcgacgata tttttgcctg aaaatctttt 2866081 tttcatacat gcgacagccg ctcttcccat ttcttttttg acccatgggg attgatcgct 2866141 gtctccggat acgataatgg catcctttag atttaaacgt tcttttaatg tcttttccaa 2866201 aagagtcaaa cctaaaacat ctttcatcgt atcttccaaa acagaaagca gttcatagcc 2866261 ctcttctgtc aatgtcatgc cgtttgtctt aatatcgacc aggttctgtt cctttaaaaa 2866321 ctgaacctcg cccctcagca cacgctcgct gattccgaga ctggcagaca ggcttcttcg 2866381 cccgatgggt tctgtcagcc tgatatactg caagatttca aacctctttt gcataacgag 2866441 cagaagatca ggcaataatt ttttttgagc ttgtattaac tggttcatga ctcaaacgtt 2866501 ccttcctttt ttgctggaca ttatatgtcc cgctatgaca aaaaacgtcc cgtcatagcc 2866561 aaaaaaaatc atttctgctt tctttaatta ttttaacagg gtggaattgt ttattcaact 2866621 gttaagagcc aattcatcga caatattcgc agagttttca tgccgcgtcg ttttatccag 2866681 caatatttta tcctatatat ctttatctta tacagaaagc gccaaatggt gcatcccaat 2866741 ataaacagcc cttcccgtag aaagggctgt ttcattaaag cgttttcatt ttatccaaag 2866801 cttttcaatt tcctcgagcg atttgttctt cgtttctgga cagatcgtaa cgacaaacag 2866861 gaaacaaagg atgttaatca ccgcaaagat ccaaaatgta taggcgagcc cgaaagaatc 2866921 gatcatcatt ggcacaaact gtccgatcgc ccagtttgct ccccataaaa agatggtcgc 2866981 aatgcccgcg gcccgcgcac gcagatggtt cgggaagatt tcagaaatca taatccatgt 2867041 gatcggtccg accgagacac agaaagcagc gacaaaacct aatataagga cgatcatcat 2867101 gatcccgctt gttaactcaa aataaaacga cgtcccgatt aaaatcataa aaatagccat 2867161 aaaagcagaa ccgatggaca tcagtttttt tcgtccgact ttatcaatca gcaacaccgc 2867221 aataacggta aaaataactt ctacaacccc gacgatacaa gtcgtcacaa atccggcgtt 2867281 ttgcccgaat cccatcattt taaagatttc cggcccgtag taagtaatcg cgttcatgcc 2867341 gatgacttgg ttaaacagcg ccagcaggat tccaatgaca agcgcctttc tgagacccgg 2867401 cttaaacagc tgggagagcg accccatttg ttctattttt aaagagttct caatgttctt 2867461 taattcttct tttgcaacag tttctccatt aatacgtgtc aggatcttta aagcttcatt 2867521 tgttttgccc gctttcgcca gccatctcgg actttccggg acgacgagca ggacaaggaa 2867581 aaaaatgacg gatggcacca ttccataagc aagcatccat ctccagccgg tgtgcacgcc 2867641 ccattcgtat gttccggacc gctgcacagc tagattaata aagtatgttg cggaaatacc 2867701 cagtatcgta aagagctgat ataacgaaga taaacttccg cgtatagcgg gcggtgccgc 2867761 ttctgtaata tacgtaacag agagcgatga gcccatcccg attcccagcc ccccgataat 2867821 ccttgcaatg attaaggtgg acacgtcttg agaaagcgct gaaacgattg ctgatatcgc 2867881 aaataacaaa gcggctgtca ttaaaatttt tctccggccg aatctgtcac ttaaaaatcc 2867941 ggatatcccg acgcccacaa ctcctccaat cataatgctt gaaatgacaa gtccctccat 2868001 aaacggactc aggctgtata aatctttcag aaaaccgatg gcgccagaaa tcactgccgt 2868061 gtcatagcca tacaataagc cgccaagccc cgccgcacat gagatcaaaa tgacaaatcc 2868121 cattgaatgg cttcttgtta caggaacatt tggttctaat tgagttggag tattcttcat 2868181 ttccctgccc tcccgaatgt tgagtaaagc gttttcattt aaaccttcaa ttgtacgtac 2868241 ttatattaaa atttaacgaa aattacattt aattagtacg tacaaatata gaataatctt 2868301 gtttgcattt tctgtcaatg ttttcttaca aagaacgctg tgatatactg aaatttgtcc 2868361 gtatacattt tggaggaatg gatatgttac caaaatacgc gcaagtaaaa gaagaaatca 2868421 gttcttggat taatcaaggc aaaatactgc ccgatcaaaa aatccctacc gaaaacgaat 2868481 taatgcagca attcggcgtc agccggcata ccatccgcaa agcgatcgga gacctcgtat 2868541 cacaaggtct gctgtacagc gtgcaaggcg gaggcacctt tgtcgcttca cgctctgcta 2868601 agtcagcgct gcattccaat aaaacgatcg gtgttttgac aacttacata tcagactata 2868661 ttttcccgag catcatcaga ggaatcgagt cctatttaag cgagcagggg tattctatgc 2868721 ttttgacaag cacaaacaac aacccggaca atgaaagaag aggcttagaa aacctgctgt 2868781 cccagcatat tgacggactc atcgtagaac cgacaaaaag cgcccttcaa accccaaaca 2868841 tcggctatta tctgaacttg gagaaaaacg gcattccttt tgcgatgatt aacgcgtcat 2868901 atgccgagct tgccgcgcca agttttacct tggatgatgt gaaaggcggg atgatggcgg 2868961 cggagcattt gctttctctc ggccacacgc atatgatggg tatttttaaa gctgatgaca 2869021 cacaaggcgt gaaacggatg aacggattta tacaggcgca ccgggagcgt gagttgtttc 2869081 cttctccgga tatgatcgtg acatttacaa cggaagaaaa agaatcaaaa cttctggaga 2869141 aagtaaaagc cacactggag aaaaacagca agcacatgcc gacagccatt ctttgttata 2869201 acgatgaaat tgcgctgaag gtgattgata tgctgaggga gatggatctt aaagtgccgg 2869261 aggatatgtc tattgtcggg tacgatgatt cacatttcgc ccaaatctca gaagtgaaac 2869321 taacctctgt caaacatccg aaatcagtgc ttggaaaagc agccgccaaa tatgtcattg 2869381 actgcttaga gcataaaaag ccgaagcaag aggatgtcat atttgagcct gagttgatca 2869441 ttcgccagtc cgcacgaaaa ctgaatgaat aaaaaaagca atgtatgggt ctccccgcta 2869501 cattgctttt tttatagctg ttatctgttt ttccaaacgt cagcgatgat ttcaaacgaa 2869561 cgcattctgt ctgcgtgttc aaaggtttct gagttaacca taatttcgtc agcctgtgtc 2869621 gttttgacga aatcttcaag cttcgccttc acttcttccg gacctccgac aatcgtggag 2869681 ctcagctgct cattgaccat cgctttttca tacgggctcc agatttggtc catatcctca 2869741 acaggcggtt taagctggtt aggcgtaccg cggacaagat caagaaacct ttgataatgg 2869801 gaagtcgcaa ggtgctgcgc tttctcgttt gtatctgccg cgataatggt gacaccgacc 2869861 atcgcatacg gttcgtcgag cacgtctgac ggcgtgaagg aattgcggta cagctccaaa 2869921 gcgggaaccg tattcgccgg tgagaaatgg gccgcgaacg caaacggaag accaagttcg 2869981 ccagccagac gggcgctgaa gccgcttgag cccagcagcc aaatcggcac atctatgccc 2870041 tctccgggaa tggcgcgaac ttgattgcgc acatttcctg acggtttaaa ataattgcgc 2870101 agttcctcta attgttctgg aaaatcctcc ccgctgttga tgtttctgcg gagcgctctg 2870161 gctgtcaatt ggtctgttcc cggcgcacgt ccaagcccca gatcaatccg cccgggatac 2870221 agtgtttcca gtgtgccgaa ttgttcagca atgactaatg aagagtggtt ggggagcata 2870281 atgccgccgg aaccgacgcg gattttcttc gtgcctccgg caatatggcc aatcaaaact 2870341 gcggtggcag agcttgcaac accttctata ttatgatgtt cagcaagcca gtaacggtga 2870401 tagccccatt cctctgcccg gcgcgccaag tccatgctgt ttcggaatga ttctgcaatc 2870461 gttcctccct gaacaaccgg agataaattc aagacagaaa gcaaggtatc tttgcgttgg 2870521 ttgttagaca tattgttctc ctttgcaaat gtgttatcag taaacagccc aaagctgtca 2870581 ggtcatgatt gaaagaactt ctatcacacc ataacacaac tgcattcagg aataaaagaa 2870641 tttgattcga tgaaattcga acaatataaa acgaacggtt tggaacatta ttctgctcca 2870701 aacaactcct tagccatctc aataaagagc ttagccgcca gagaagcctc ctttagcgac 2870761 ggaacagcaa gctgcacatc acggtatacc tgcgggtcca attccctggt caccacatgc 2870821 tctggcagcg gcatccccga catggacatt tctgataaaa tggccaggcc caggccttct 2870881 ctgatcatac tgatcgaggt gttgatgtta tagaccgtga aagctgggtg cagcgtagca 2870941 cccgcctgcc tgaacatatc gataaatggt gattcatagc cgccgtcaca gacgatcatc 2871001 ggttcatggt caagatcttt cagcgtaatg gctgaatgac tggcaagcgg gtgatcgtcc 2871061 ctgagcacga cagccatttt gtcttttttc aaatgaatgt actccatctc ctctgttgga 2871121 tacagaagaa tcccaacatc tatcatccgc gtatgaagcc actccttgac ttcatttaca 2871181 gttccctcgt gcagcacgag ctcaagtttc ggatattttt gtttaaattc actgatcagc 2871241 ttcggcataa aataagccga ggcagttgag aatgtgccga tatggatcgt tcccagttca 2871301 agcccttttt ccgctgctgc tacctgctca actttttcaa tgccttttaa gacttctctg 2871361 atgtgtacta agatctgttt tcccgtatcc gtcagcatca ggccattgcg gcggtcacga 2871421 atgatcagct ttacatcaag ctcagcttcg atcgcagaaa tcgcatggct gacagccggc 2871481 tgtgtcatgt tcagcgcctg acccgctttt gtaaagcttc ccgtttcagc tattttcaca 2871541 aaaaccttta attgagtaat ggtcataaca atttacttat gctccttata aaaaagattc 2871601 attttattta tcttatgttc taccgtatca tatgatggaa aagttctaca aggagtgaat 2871661 gaacaatgaa gcagctccca aaaacgcgga cagctctcct gctcgcattt ctcgtcatca 2871721 tgtggggcgt caattggccg ctgtccaaag ccgcgctcgc ctattctccg ccattattgt 2871781 tcgcgggcat ccgaacgctg atcggcgggc ttttattagt catagtcgca ctgccgcgta 2871841 ttcataaatt acgcttaaaa gaaacgtggc cgatttatct tgtttctgct cttttaaata 2871901 ttacattatt ctacggcctg caaacgatcg ggctgaatta tcttccggcc ggcctgtttt 2871961 ctgcaatcgt cttcttccag cctgttctga tgggtgtatt ttcttggctg tggctcggcg 2872021 aatccatgtt tgtaatgaaa gtgattggcc tcatcctcgg ttttgcggga gtagccgtca 2872081 ttagtgctgc gggctttggc gggcatattt ctgtcattgg ggttctgctg gctctcggct 2872141 ccgcagtcag ctgggcgctc gggacagtat atatgaaaaa aacaggcagc cgcgtcgatt 2872201 ccatctggat ggtcgctctg cagctgacga tcggaagcgt gtttctgctt atctccggct 2872261 tttggacaga aagcttttcg gcgatccaat ggacagctcc gtttattacg agcctgctgt 2872321 tcatctccgt attcgttatc gcactcggct ggcttgtctt ttttacgctt gtcggttcag 2872381 gagaagcaag caaggtcgca tcttatactt ttttgattcc gctcatatca atcgtggcca 2872441 gctccatttt cctgcatgaa ccgctcaccc ttagcctctt ggcagggctg ctgctgattg 2872501 tcacgagcat ctgtctcgtg aatacaaaat caaaagcgca gaaagctgcg gcgattggta 2872561 taaacgagaa agctgcacaa taataaaaac cctcttgccg gatgcggcaa gagggtttct 2872621 tatttactga tgcttgcgtc ctttgaccaa atatgcaact gtaatcaaaa ggtagatcgc 2872681 cgcagtaatg ccggtaatga caattgatgt tgtcatgatg accccgatca gaatggcgag 2872741 taatgccaca atcgcaaacc atgtcgtgta cgggaaccat tttacataat aggccggtgt 2872801 ttccgtttgc tgttttctcg attttaaatg agcgaatccg atgatcagcc aaatgaataa 2872861 aacggtatat cccaatgatc ccattaaata attaaatgtt tggcttcctg cgaacagaga 2872921 aatcaatacg ccaatataga gagaagaagt gcacatcaga atcgcaaaca tcggtacgtt 2872981 tttcgatgaa agcttcgaga agacctttgg aagccttccg tcacttgcct gtgtatacaa 2873041 aatgcgtgat gatccgtata aacctgaatt catagaagaa atgatcgcca gcaggatgac 2873101 tgcattcatg atatgatccg cgcccggaat gcctaccatt ttaaagacca tcacgaaagg 2873161 actttccgga acggaattga cttggttcca tggaatcagg ctgacgatga tgaaaaacgg 2873221 cagcaggtaa aacgcgacaa tccgtgtcag tgtgctgcgg acagctttcg ggacaacctt 2873281 ttccggattt tttgtctctg caagcgttac accgataatt tctgtaccgc cgtaagagta 2873341 gatgacgaca agcatcgccg tgatcagccc tgtgccgccg tgcgggaaaa atccgccgtg 2873401 gtctgtcagg ttggaaaatc cggatgctgt atgatcaccg aatgatacaa ataagagcag 2873461 caatcccaga ataataaaga taataataac ggtaatcttg atcattgcca gccaatattc 2873521 agtttcggcg aagattttaa cagaaagcaa gtttacaatc gtgacgataa gagaaattcc 2873581 taatgccaac acccagatcg ggcagcccgg cagccaatat tgaatgaaaa tcgcagctac 2873641 aacagcttca gccgcaatgt taagcaccca cattttccag tagatccagt ccaaaaagta 2873701 agcagcgtaa tttcccaata cctgctggac aagatcacgg aaggttctgg cgttacggtt 2873761 tcgaacagcc atttccgcca gcccctgcat aataaacagc aaaataatcc cgccgagcag 2873821 gtatgcgata atgacagatg gccctgccac atcgatcgct gagctgctcc ccttaaataa 2873881 acctgcgccg attgctccgc ccagcgccat catcataata tggcgggacg tcatcgtgcg 2873941 ttttaacgtt tgattgtcgt ttttcatcct cttctacctc tccttctcgt tttcaaaaac 2874001 aaaaaagccc gccgtctcct acctaatcta atagataaag agacgacgag ccttcggctg 2874061 accgcggtac cactcttgtt gattcttcat gaagaatcct gcttttgacc tgtaacgaag 2874121 gttagccgtt aaaacatagg gaatattcaa tctattccgt tccgtcttac cactcccggg 2874181 cgagttcaaa gaagaatcag gctgcgtcgc accaccccgc agctctctgt tctgatcact 2874241 ttcttttact gctcccaatc tatgtgtttt agttttctga aaaactcaaa ttttatgatc 2874301 tgaatatatt aacataatat acgtgcttct cttttaactg tcaataactt cagagaaaaa 2874361 agaaactgtt attttgtccc ttttcgaatg gctttccaaa aggattctga ctcgtttcct 2874421 aatgcgtaaa ctgaaacacc tgctatttta tattgctttg ccagatggct tttcgtttga 2874481 acggtttttt cgttttcata ccacacgaca tgtttatgct tctttttgtc aacataagaa 2874541 aacgtcatcg agcctgattt tttgttgaat gccggctttg ctttttgttt tttgatgagg 2874601 gatttgagct cattccattc ccttattgtg ctggtacttc cgtcttttac atcccagtca 2874661 tagccgtacg cagggattcc catgatgact ttattggctt tgatcttttt gactgaaaac 2874721 tgcagagagc ttttgatcca gtttgtgctt gccactgacc ccggctcacc ccaaatgccg 2874781 tgttcatcgt aggtcatgac ttgtacgaag tcggcatatt tgccgatttt cgcataatca 2874841 tacggccagc tccagtcatc atttttatca tcggcgcttt tggccggaac ggataccatt 2874901 gttttaatat gtttcttatt caaagcctgt gagacatatt gaatgaagtt cgagtatgca 2874961 gcgcggtctt ctggatttac tgcttcaaaa tcgatattga ttccgtaata tgagtgcttt 2875021 ttggccagtg taattaactg atctgtgaat cgttttttcg ctgttttatt gctcatgacc 2875081 cgactcgcta aatctccgtc aaaatcataa atggcatcat tatagtttga aatgacagcc 2875141 catgtcttga tttttttctt tttcgcatat gtcagctgct tagttggggc atcgccaatg 2875201 atttgtccgt ttttttcaaa cgcaaatgta tcggttgcga tggcattcat gtatgtatga 2875261 tatttcgtaa gagaattgta tgaagccgta tccccagtcg tgtagcctac tgtcataccg 2875321 gctgccttcg cttctccttt tgtatacata aacagaacaa tcgcaatcgc cagtgaaacc 2875381 gctatgatca gccatttttt catcgcattt cctcctgtat caagtcatac tcttctcatc 2875441 ggccaaaaaa ttggaagttg aagttttttc aagcaaaaag cccggcatat gcctgccggg 2875501 cttcctgagt tcagcggtca gagacgagaa tatatgctgc ctttactggt ccatgcaccc 2875561 ccacaactaa atccatttca atgtcggctg agttactcgg tccggtaatg tagttgatac 2875621 atgaaggaac agtgacaccg ttcgcaatgt tttggcggat gatatcactg gcttgtgtca 2875681 ttctcggtac aatgcttgat ttcggcacga tcgcaatata agtcgttggc aaaaggctga 2875741 cagagcggcc gatgtctttt gaggagaaga ggacaaccgt ccccgactca gccaatgtaa 2875801 tttcgctgaa tgtaatccct acattggctt gctccgcttt tttaatattt tcctcgcctt 2875861 tgtcagcatc ccactcccag accggcgttc cttcactcgg ccagtccttg gtgagcaggc 2875921 ttttcagtcc gtattcttca aagcgggggt ccttcggaat gatgacaggg cctccagaaa 2875981 agcggctgac ttgctcgcgc agggcatcgt aaaggccggt tgaatccgtt tcaatcagct 2876041 ctgtatggat tttgacacaa tggtttttga gcactgtgac taagtcatcc gctgaataac 2876101 cttcaagtgt tttatattgc ggctgatgcg cccattcagg gactgccacg cctcctgttc 2876161 ttcgttcacg gcccaggctg gatgcgattc ggtttaaaaa gctctcttga ttctgaatgg 2876221 ttcccttcgt catcactgct cctccttcgt gcgttcactt gtttctctgt ccgcaaacca 2876281 gtctctgaat ctcgatttat gcggtgccgg gaagtcgcga atctgggtcc aatttttaag 2876341 cgggccgggc cctttcgaaa ttttttcgtc ctctgtaaaa ggcgtcatgg cggccggcgc 2876401 ccattttgag cccattttgt aaagcgataa ggaggatgcg ccaagtccga atgctttcat 2876461 tgcaagcttt tcactgatcg gcgccctgcc ttctttttcg acgatattct gacgatgctt 2876521 gagtagcagc tcatgaagcg ggattttgac cgggcaggct tctgaacaag cagcgcacag 2876581 tgaagatgcg tacggcagct ccttataatc gtcataaccg ccgagcaacg gtgataaaac 2876641 agctccgatc ggccccgagt agattgagcc gtatgaatgt ccgccgacat ggcggtacac 2876701 aggacagaca ttgatacagg cggcacagcg gatacattgc agcacagact ggaattccgt 2876761 tccaaggata ttggatcgtc cattatcaac gatgacaaga tggaattctt ccggaccgtc 2876821 cacttcacct tccagcttcg gacccgtcaa agctgtaata tagcttgtca gccgctgtcc 2876881 gacagcactt ctagtcagca tgctgactag cacttcaaat tcagaaaatg acgggacaat 2876941 ccgctccatt cccatgacgg taatttgtgt tttcggcaag gtgctcacaa gccgtccatt 2877001 tccttcattg gtcacaaggc tgacggaacc cgtgtcagcg atggcgaagt tacagccggt 2877061 aatgccgata tccgcttcca gaaacttttt ccggagaatg gcgcgcgcat gcatcaccag 2877121 ctcttccggt ttttctgtat gttgatagtc cagtctttct ttaaacacat cgcgtatctg 2877181 ctctttattt ttatgaagag cgggcgctac gatatgtgac ggcggatcgt gatcatcaat 2877241 ctgcaaaata tactcgccga gatcggtttc tacgacttca cagccttcct tctccagcac 2877301 ctcattcaga ttgatttcct ctgtgaccat tgatttagat ttcacaattt tcttcccgtt 2877361 cttcttttga atgacatccc gaatatagga agacgcctct tccgctgttt tcgcgaaata 2877421 gacatgtccg cctcttttcg ccacattttc ggcaagctgt ccgagataga aatcaaggtt 2877481 ttcaaggaca tgctgcctga tttcctctga taatgagcgc cactcctccc agtttcccag 2877541 ttcttctgct gcctctaggc gccgcgtccg cagacgctcc tgtgcacctg aaacagcgcc 2877601 tctcataaat tcattatcaa tcccctgtga tacccgctct ttaaaagcgt cagtaccgat 2877661 tttcatcgcc atgatccttt ccccctctga atccagtttt atctgctgtt gagcacttcg 2877721 gcgatgtgca tcactttgac attcttatct tttcggccaa gccgtccccc gatattcatc 2877781 aaacagccgc agtcagcacc gatcagcacc tctgctcccg tttcctccac acattcgact 2877841 ttttcatcga ccatctgctc agaaatctgc gccatcttga ctgagaacgt tcctccgaat 2877901 ccgcagcagt tatgtttgcc cggaagctct gtaaactgca ggcccttcac atggctcaac 2877961 agcttcatcg gctccttccg aacacccagc agcctagtca tatggcacga cgtatgtaag 2878021 gtcgcttttg tatgaagggt cgcgccgaca tcctctaccc caaggacgtt cacaataaaa 2878081 tctgtcagtt catacgtttt atccgccagc tttttcgctt tatcggccca tttcggatca 2878141 tcctgaaaca ggtgcggata ctcccggaac atcgttgtgc aggaacccga aggactgaca 2878201 acatattcgg aatcctgaaa cgtttcgatc atccgtttca ttgctttttt ggcgtcatgt 2878261 acatagccgc tgttgtaagc cggctgtccg cagcaaatct gcccttctgg aaaatcaacc 2878321 tcgcacccaa gccgctccag cagctcaacc gttgcttttc cgacatttgt ttgaaacata 2878381 tcaacaagac aagtgacaaa aagtgagact ttcatgatga acccctctct catccccaat 2878441 atatgatcag gtcatctgat gacctgagtt aaaataacta tatgaatatc gtacactatt 2878501 ctgacaatgg aaggaaagag ttttctaggg atattttcat ttgtggcata tcaaaaacac 2878561 tcccgatctc ccaggagtgc agtatatggt tagatccagc ccttttcctc agcgatgctg 2878621 gcggcttctg tccgattttt cgcattaagc ttttggatga tttctgagat atagtttcga 2878681 actgtgcctt gagataaata gagctccagc gtaatgtctt ttgttgtctt gcctaaagcc 2878741 gcaagcctca gaatttcttg ctctctaacg gttagcggat tttcgtctcg catcatatta 2878801 aacgtcagct cagggctgaa gacacgtttt ccctttacac attttcgaat ggcatcggcc 2878861 agatcgtcaa tttcaccgtc tttcagcaga tagccatgtg caccggcctt tacggcgcgt 2878921 tcaaaatatc cggggcgggc aaaggtggtt aaaataatga ccttgctgac gcagcctttt 2878981 ttcattaatt cctctgccac attcagcccg cttcgaaccg gcatttcaat gtccataatg 2879041 catacatccg gctccagctt caaaatagca tgtagcgcct cttccccgtt taatgcttgt 2879101 ccgatgactg tcatatcctc ttctaaatca agcaaagatc ccaaagcgcc taaaagcatt 2879161 cgctggtcct cagcaataaa cagacgaatc attcttttcg tcctccaatc attctgcttt 2879221 tttaataagc ggaatcgtca gtgccacaac cgttccgtta tggtctgaaa ccgttaatcc 2879281 cccttcaatg agcatgagcc gttcttccat tccccacagg ccattcccaa acattttctc 2879341 cttcggcgct ccctttccgt catcccgtat tacgatcctc attttgtcag caaattgaga 2879401 aatggtgatg gcacagtggg ttgctttgct gtgcttgata atgttagtca cggcttcccg 2879461 catacacata ctgataatat tttgagtgac gggagatatc actgaaaagt cgtcggctcc 2879521 ttcgtattga aaggtaatgt tccccgctct taatatgtgc tgaatgttta cgagctcctc 2879581 tgttatcgtg accgttctca tatcagaaac cagctctcga acttgcttga gtgcggagcg 2879641 tgaactggtt tccatttctt ttgcctcaag cttggtccgt tctggatcag atgcagccag 2879701 ccgctgaatg agctggcttt ttaatgtaag cagcgacagg gtgtggccaa gagtatcgtg 2879761 aagatcacgg gcgattcgaa cacgttcctc ccttttagag agttctttta tctgttcgtt 2879821 ggcttgtgca agcttagctt caagctcaat cctccgaaac atagaacgaa ttccgaatgg 2879881 agaaatgagc ataatgacga gaaacgggag aacagaaaaa agctcccgaa gcgagaccga 2879941 attcgcgata aattggtata ggcatggaaa aagcagtata aagattaaag cgcagaacgc 2880001 acggttaaaa ttcgttttct ctttgtaata accaacaaag tttgccggaa aaaaacctaa 2880061 gtatatatag gtgatattgt aaaacacact atacatcaaa ataaccgcca tttgcacgat 2880121 aagccaatat gtaaacgaag ctttgcccac gctgcagaat aactggcgat atgccgctac 2880181 aaaaaggagc agcataccat atccgatccc ctgtttgacc cctgattctt ttaataaaga 2880241 gaggaacggc ataatcgtat acaccagaaa gatataaggg aaaaacccga attccttcgg 2880301 gaaaatagat attgcctttt tcatgtatta caccgcttct tgttttcttc ttatatattt 2880361 agatagtagc atgaagagca tcatataagc gattaatatc agaatatttt tccaagtcgg 2880421 actcccaccc cggacaagtt cccacgctcc gctcccgaaa tgataagacg gaagccactg 2880481 gccaatgctc tgcatcatgt caggcatgac ctcaaacggc atccacatcc ctccgcctaa 2880541 agccagcagc atataaagca cattactgat tccggccgct gtttctactt ttctcatgag 2880601 gccgattagt gtgcctaatg ctaaaaaagg caatgcgcca aacaaaatcc acagtccgct 2880661 catcatccat tcaaacggtg acaaggcaat atcattgatg attgcgccga acagaaatat 2880721 gacggtaatt gataaaacgt gaatgacact ttggccgatc atctgagctg ataaatagat 2880781 atgatccgga agaggcgtaa ggcggataaa ggcggcccag ccttgtgacc gttcttgtac 2880841 cattcggatg ccaagcgtca tgatagagga acccatcacg ctgaagactg tcatcgacat 2880901 caggtaatgg gcttcccatg cacgttgatc agggacgttg gtattcacta catttgtaaa 2880961 gaaataataa aaggcaatcg gcatgatcag agaccaaagc acaaagtact tgttcctaag 2881021 cacccttttc atttcagcga tgctttgctt ttgcagcacg ttcactcaca tcgcctccct 2881081 gttgccgtca gccagctggc gaaatgcctc atcgagcgtt gcttgctcaa ttcgaatatc 2881141 ccgtgcatgt atgttttctt gaaagatcag cgccaacact ttgtctgtat ttgatgtctg 2881201 gatgatggtt ctctcatgct cgtggatcac tctctcgact tccgggtgac aagacagcct 2881261 ttccaatgat tcacttgaat gaagcgtaaa ggaaacagac tgtttttgaa ttcttgagcg 2881321 gatttgcatt ggtgagccgt ctgcaacaag ctgtccttca gtaaaaaata ggattcgctg 2881381 tgcggcatca tctgcttcct gtaaataatg agttgaaaaa ataatcgttt ttccttggtc 2881441 cgacagtccg tgaatggtct gccagaatcg gtgtcttgat gaagtgtcca tgccgactgt 2881501 cggttcatca agtataagca gctccgggtt cccggcaaga gccaaagcaa agctcaaacg 2881561 gcgtttttgt ccgccggata atttttctgc tcttgttttc aaatcttctt tggtgagtgc 2881621 tgttaacgaa acgagttctt tcatggacaa tggattcgga taatagctcc ggaagagttc 2881681 aaggatttca tccaccttaa ggcccggcat gacacttact tcctgaagca ttacacctat 2881741 tttttcacga acctgttgat catcgggaac ccggttaaat agtttgattt ctccctcact 2881801 cggtttcagc aatcctaata tcatcgagac gacggtcgtc ttccctgccc catttggccc 2881861 gagaatggct gcaatttctc ctttttcaat actgaagctg atgttgttta cagcggtttt 2881921 tcgctggaaa tgttttgtca cgttgcttac tgttactgct tctttcatca catgagcacc 2881981 tcctgatcgt ttacattgat tgtaaaatga cggagaagac gatgttagta tggggtgtca 2882041 tgatgatgga gtgacaaatg tcattttttt ctcaccccgg tgtctaggca atcctcctcc 2882101 tgcatcttcc aattcatcca tcttttctat ctcccatgtc ctctttcttt taaactgctg 2882161 tgacattcat agaaagatac actcttcaaa ccatccgagt gttatgatag aaatattgaa 2882221 ctttatatta ctttccggct gaaaggagcc aatcatgaac gaagcgattt tgtctagaaa 2882281 tcatgtgaag gtgaaaggca gcggcaaagc atctatcatg ttcgcacctg gttttggatg 2882341 cgatcaaagc gtgtggaatg ccgtggcacc tgcctttgaa gaagatcatc gggtgatttt 2882401 atttgattac gtcggttcgg gacattcaga tttgcgcgca tatgacctga atcgttacca 2882461 gacacttgac ggctatgccc aggatgttct tgatgtttgt gaagctttag atctgaagga 2882521 aaccgtgttt gtgggtcact ccgtcggggc cttgattggg atgcttgcat ccatccgccg 2882581 cccggagctt ttttcccatc tggtgatggt ggggccttct ccttgctatt tgaatgatcc 2882641 gcctgagtat tacggaggat ttgaagagga gcagctcctt ggcttgctgg agatgatgga 2882701 gaaaaattat atcggctggg cgactgtatt tgcggcaacc gttctgaatc agccagatcg 2882761 gcctgaaatt aaggaagagc ttgaaagccg tttttgttct actgatcctg tcattgcccg 2882821 ccaattcgcg aaagcggcgt ttttttctga tcaccgagag gatctttcga aggtaacggt 2882881 tccctctctt attctccaat gtgcagatga tatcatcgca cctgcaacag taggtaagta 2882941 tatgcatcag catctgcctt atagcagtct gaaacaaatg gaggctcgcg gacattgccc 2883001 tcatatgagc catccagatg agacgataca gctgatcggc gattatttaa aagcacacgt 2883061 gtgatatagg aacgaaaggg atagaggtga ccctcttaga tggacaaaca attgaatgat 2883121 gcaccatgcg gtttcctcgc tttgtcagaa gaggggtcga tcatagctgc caaccgcacc 2883181 cttatcaaga ttctggatta tgaaccggag caggttatcg gccagcacat gaatatgatg 2883241 ttgaccattc ccgcgcagct tttctgccag ctttattttt ttccgctttt gaaattggag 2883301 catcacatcg aagaaatata catttccctg aaagcaagag atggagaaga aattcccgtc 2883361 cttatcaatg ctattgcgag acacgatagc ggggcttctg tctttgattg tgttctgatt 2883421 ccaatgcgaa agcgaaatga atatgaaaat gagctgctga tagccagaaa tgaggctcag 2883481 gaagctttgc ttgccaaaca gaaagccaat gcggagttag aaattgcctt ggaaacgctg 2883541 aaagcaaaac aagaagaact tcttgagatc aataaacaaa atcaacaatt taaattaaac 2883601 accaaaagag agcttgaact cgccagaaag atccagaaaa actcgttgac tgaaccgatt 2883661 gtaaacgatc aggttcagat tgactcttat tacaacgcat cgagtgaatt gtcaggtgat 2883721 ctttacggat attatcaaat cgatgaacac cgttacggca ttattatcct tgatgtgatg 2883781 gggcacggaa tttcatctgc attgattacg atgtctcttc atcctttgtt ccagcgccag 2883841 atcacgcaag gtctcagccc cgttaaagtt atgaaggaat tggaccggca ccttcacagc 2883901 ttgtttcaaa atgatgagga agcaagacat tattgcactg ctatttatct cgagattgat 2883961 atagcacggc aaagaattga ttatgtcaac gcagggcatc cgccggcact ttggcaggac 2884021 gatagcggaa ctcaacatct gcttcacgcg acctcgcctc cgatcgggat gtttgaagac 2884081 ttagagtttc agtcaagcag cctttcatac acggaggacg gaagattgct tctgtatacg 2884141 gatggcgtga tggatcctac ggcttcatgt tatttatttg atttactaaa ggatcatcct 2884201 gattcgccaa tcgctgacct gaaggagaaa atccttacat cactgcagca tcaaaaggaa 2884261 gctcatcata agagtgatga cgaatgtttt atattagttg atgtaaaata aaatgatcca 2884321 tgagacataa caatgatttg ttacatctca tggatttttt tgtttcagcg tttctttgga 2884381 atatgtcctg actccgcata ttgaaacacc tgcaaggaag gcagcgggtg tccattaaaa 2884441 tcaaataaag cttgattatc tacagcactt cccccatacc acttcccggc gtcttcaggg 2884501 tcgtattcag cagcatagct ggacgcccac cctgacccgt atgtttccca taacactttg 2884561 tttttctcta tctgtgtctt cggcccgact ggaatccacg ccggctccca gtagaaaaca 2884621 ccaagtcctg ctttgcccgt attcgccact gcctccatta catctcttac tgcagttgcc 2884681 tggccttgaa cagaaattgg atatggcaac gtctgcccgc tttttggtgc tgtatttcca 2884741 tgcccatcgc catcctcagc ggtataggtg tacgatgtct ccgccaccat gacttttttg 2884801 ccgtacgtat tggcaacagc cttcagcacg gaggtcaaat tttgtaatgt gccatgccag 2884861 aaaggataat aggagctagc aaacacatca taatccactt tgtttttgct gagtgtttct 2884921 gcaataaatg aataccttcc agccgtttca ggattggtaa aatgcagggc gaccaaaata 2884981 tttgaatttg tctccctgac cgctcggctt ccttcattaa ataattggca catcttcgtc 2885041 caatcagtct caccggcaaa tcctcctgtt gtttcatttc cgacctgaac catgccgatg 2885101 tcaacgcctt ccttgatcat cttttgcagg ctttgtttcg tatactcata gagctttgct 2885161 ttttttgctt caaagctgag attcgcccag gctttgggca ccttttgttt cgctggatcg 2885221 gcccagaaat cagagtagtg aaagtcggcc agcaccttca ttccgttcgc tgtcgctctt 2885281 tttccgattt cgatggcttt ttgaacatca ttgtttcccc cgccataccc gttgccattt 2885341 gaatcatacg ggtgattcca gatgcggacg cgaacatagt tgaccccagc ctgttttaaa 2885401 gttgtaaaga tatcctggcg ttttccgttt gtattgtaaa aggtgacacc gctgttttcc 2885461 aaagcaataa cgctggatac atctgcccct ttgataaaat ccttgttcat cccctctact 2885521 tttttaacaa aaagatcctc tgcccgaagc tctgacacgt gcttctcctt ctcaatggca 2885581 gcggcatatc ctgttgaact acatgcactc cacacgatgg cagccgcaaa gaacattttc 2885641 actttgcttt tcatgatttc atccccccaa gacttagcaa gcgttttcat tctatagaaa 2885701 aaagaatccg cccatatcga gcggagcatc agcctaatgt gtgtttacga caattctcac 2885761 ttcatacttt tccatcgtca ggtcgcctga caatatgtct cctgtcatta tgtccttcac 2885821 actctgatca aacgtgacca gctgtttttc ttccgtgaaa ttcatgacaa aaatataatc 2885881 attgtcctga tcctgcctcg cttgtacgga gacgcctttt ccgtgccgaa ccggaaaaac 2885941 tggagagaga gacaggtctg tgatcagacc ctcatagaaa tcacgctgaa attgatcctc 2886001 caaacgcgcg ccgataaaat acgccttgcc ctgctgatac tcatggcttg tgaccgctgg 2886061 cgtgcgcgca taaaaatctt cttgatacac cgcttccact gaagctgtct ttacatcaat 2886121 cacggttgca taatccttca tttcatatat ttggctgcgg tagctgacag cgtttcgatc 2886181 cttcggatac agggtgtccg tttcaagagg ctcaactcca aatatagctt gaagatccgg 2886241 atgccatccg cctgtgtatg ttaagtcatg ctcattcaca accccgctga tatacgtcat 2886301 gactaaggtg ccgccgtcag ccgtaaacgc ttttaaacgg gaaacggtgt cctcgctgat 2886361 taaatacagc atcgggacga tcagcagttt atatggtgaa aagtcttgtt ctttcgtgat 2886421 gacgtcgaca gggatatcgt gttcccagaa tgtgcggtaa tgctgctgaa gcgtttgcgg 2886481 ataacgtttt gtcgccttcg caaacccctg agcatcctcg agcgcccaat gattttccca 2886541 gtcatataaa atcgcggttt gagccggcct cttcgttccg acaacttcgg acagccgttc 2886601 caatgtctcg cctaccttgg ccacttcttg aaagacgcgg ttcttcgggc tattgtcatg 2886661 atccacaacc gctccgtgta atttttctga tgacccccgt gatttgcggt attggaaata 2886721 gagaacgctg tccgagccgt gggcaatcat ttgcatggat gacagcagat tcatgcccgg 2886781 gcgctttgcc ttgttgacgt tatgccaatt gaccgcgctt ggcgtacact ccattaataa 2886841 gaagggctgc tgcttcaagc ttcggtacag atcattgata aagccgacct tcatcgccaa 2886901 atcagctgtg ctttcccagt cattgtgcca gacaggataa gcgtcccagc tgatggcatc 2886961 gacatgcttt gcaaatttgc tgtagtcgag gccctgatac gggatcaaat ccggtgtgtc 2887021 agccataaaa ttcgttgtga tagggatatc aggcgtcaat tctttcagcg gaatgatttc 2887081 attttcataa aacgaaatcg tttgatcggt gacgaaccgg cgccaatcta aattcaggcc 2887141 atgcaagcca ttttcaccga tcggcgaagg gctttcaatt tgtgaccagt cattgaacgt 2887201 atggctccaa aaaggggtcc accacgcatg gttcaatgtc ttgaggctgt tgtcatattt 2887261 cgatttcagc cactcccgga aagcatgctg gcataaatca cagtggcaat ctcccccgta 2887321 ttcgtttgaa atgtgccaca ttaacagcgc cgggtgatgt ccgtatcgtt ctgctaataa 2887381 gcggttgatg tgccgtgttt tttctcggta gactttagat gtgaggcagt ggttgtgcct 2887441 tccgccgtgc agctgtttga cgcgggaggc attgacgcgc aaaacttccg gataggtttg 2887501 cgacagccag gccggacggg ctccgctcgg cgttgctaat atgacccggc cgcctatact 2887561 gtgaatccgc tcaaaaatat catccagcca ttcaaattga tatacgccct cctccggctc 2887621 aagtgcgctc catgcaaaaa tgccgacaga aaacgtattc gtatgagaaa gcttcatcag 2887681 tttgatatcg tcagctaaaa tatcgggccg atccagccac tgatcggggt tgtagtctcc 2887741 cccatggagc ataaattttg cttttgttac gtgcgttttt tcaagctttg acatcacatt 2887801 ctcctccttg ttctcttagc ccttcgttcc gcctgcggtt aatccggaca caaaattctt 2887861 ttgcagcata ataaagatga cggcaaccgg tatgctgata agcagggctc cggccgcaaa 2887921 tgtcgtatag ctggccccca tgacatcatt cactaaattg aatagaccga cgggcaatgt 2887981 atatgattca ggcgttctca atatggttga ggacagcaca aaatctccga gcggaccggt 2888041 aaagccgttc atggccacga ctgccgccat cggttttgat aatggcagaa tgatctggaa 2888101 gaagattctg gtgctgctgg ctccgtcaat cttggcgctt tcgtctaaat ccatcggaat 2888161 ggaatccatg taccctttca tcaaatacgt attcatcggg atcaggccgc cgatataaag 2888221 caagattagc agccagtggc tattgatcat tcccaagatt tgcgccagca caaacaaggc 2888281 aattaaagct gaaaactgag gaatcatctg cagcaataaa aagagcgtta aagcgtattt 2888341 cctcccttta aaccgaaagc gcgaaaacgc ataggccgta aacgtcacac agagcaaaga 2888401 ccctgccatt gtaaacaggc tgatcttcat agagttgaca taccactgca catattgaag 2888461 gctttccttg cccgcaaata attccttgta atgatcgaat gtcggatgct tcggaatgat 2888521 ggatgtactg attaagctgt tgccgggatt aaagcttgcg cctgccgtcc aaaggagagg 2888581 ataaacaatg atgaccgcca taaaggctag caacaagtaa gagaaaagga gacggatata 2888641 tcttctgact ttcatatctg ccagcatacc ttatgcctcc tctttaaaag actttgtctg 2888701 tctgaactgc cacaatgcga tggagataac aaatacagat aataaaatgg ttaaagccgc 2888761 agcaagtgaa tattggctgg actgcattgt caatttataa atccatgaaa cgaggatatc 2888821 tgtcccgccg gctgttgatc cggttacagc cggacctccg ccattgaata gatagataat 2888881 attaaagtta ttaaagttaa acgtaaactg agtaatgata atcggagcca ttgcaatgaa 2888941 caccatcgga agcgtgatgt atctcagctt tgaaaagaca gaagcgccat caatcgtagc 2889001 tgcttcatac agatcgtccg ggatggattg caatacgcct gttgagacga gaaagatgta 2889061 cggaaatccg agccagccct gcatgagaat caatgcaagc ctcgaccaat tggcatctgt 2889121 catccacgga agcggatcta tcccgaagaa agccaagatg tcgtgattca tcgcaccgaa 2889181 gctatcatta aacagtcccg caaaaattaa aatcgtcaca aaaccgggaa cggcccatgg 2889241 caaaatcaga atcgtccgaa aaaaacgttt aaaccgaagg tctttctggt taacaatgat 2889301 cgcgagaaaa atccccaagg tgacttgcag tgtggatgca gcaagtgtcc aaaccaccgt 2889361 ccaagccagt acatcaaaaa aagtcgacct ccaaatatca actgtgaaaa tatttgcgaa 2889421 cgtttgaaaa ccgacccaat caattaattt tgcaggagga gaatgataca aatcatagtt 2889481 tgtaaacgct aatgcaaagc tgaataagat aggaaagatc acggcgaaaa ttaaaataaa 2889541 caaagatggg ccgctgacga cataaggata gccctcagaa atgatatgct ggtattgttc 2889601 ctttaaggaa cttaatggct tattttcatc acgctgtttt ccgctttgga acgcatcgcg 2889661 aagatttaca taatacaccg caaggccaaa gcaggtcacg atgacagcaa taatcccttc 2889721 cgccagcaga aaaacggaat tatcccgcgg cacttctgtt cccagtgtaa agattcccca 2889781 aaaccccata ttgagcagat ctccaaagac cgcaaaaaac gatgcgccta agaaaagaaa 2889841 gacaatacct tttatccatt gcttgttata aaattgcccg agtcccggaa tgatagaaag 2889901 caacaaagcg acttgacgat gctgcaccgt tttcacctct cttacaatac aaatctagct 2889961 ttctctttat tttccgctgt gctttgcctt aatttgtcct ttggccgttt cagctgcttg 2890021 atccaatgct tgtttcggat ctgccttccc tgttgcaacc gtctgtaatg ctgaatcagc 2890081 cggcgtccat atttcattca tttccggaat atttggtgtt ggctctgaga aacgggattg 2890141 ttcagtaaca gcccgtgccg cctcgctttt cataatagcc gggtcattgg ctagggattt 2890201 cacagcagga acttctttcg tttcttcata tcgtgtttta gaattttttt catttgccag 2890261 gaaaacggct aattcttgcg ccagctcttc attctttgaa aatgcactga cgttgtagct 2890321 tttgacgccg ataaaggagc tcatgttttt cccattttcc agcttcggca gtttcgtaat 2890381 gccataattg attcctgcat tcgaaaaggc ttctacattc catggaccag aaataattgc 2890441 ggcggctttt ccttctgtga acagcgattc caacacgtta atcccttgtt ctccaataat 2890501 gccagccggg aacaggccat ctttgtaaaa cttctgaatc agcgccgcac ctttgacagc 2890561 tccttcatta ttgattccaa tgtctgacgg gttatagctc ccatctttgg cctttccaaa 2890621 aatgtatccg ccatatccgc tcatcacact ttctgcataa taaatttgat cgaatagggc 2890681 taaaaagcca aatttgctgc cgtcagcagt ctttttggaa tagtcgtacc actcttccag 2890741 cgttttgggc aattcctttt ctgtgatgag atctttgttg taaaaaagca cagtcgtttc 2890801 gaccgctttt ggcagtccat aaagcttttg atctaccatt tgagactgaa tggaagcgtc 2890861 agtataaagt gattgaacgt cttttttgac atgtaattcc ttgagtaatc cttccgtgac 2890921 agcggttccg atttggtccc ctggcattgt taacacgtca gggcctgtgc cggccggtcc 2890981 atccattcgc aaatcttcaa tctgcttggc atacggtttt tcaacgactt tgaccttcac 2891041 atcatgctct ttttcaaatg cagccacagc gtctttaatg ccgttgctct tttctttatc 2891101 ctcccataca acaagctctg acccttttga actcgatttg gcgctgctgc tttcctttgg 2891161 gccgcaagcc gccaaggata aactgacagc tgcgcagagc atgaatacgg aacacttttt 2891221 tgccattttc attgattgtc accctttcgg taggaatgaa agcgctttaa agataatata 2891281 gcatgcctga gaaaatgtgt aaacaaacta tttacttcat agagtaaatt tttttaccta 2891341 aataaaaaat gacttagtgt cctaagtcat ccttaattca tactcttcct gacgattaat 2891401 tctgcgccca catataatgt ttttaccgtt cttctcttgt cctgcacttg ttcaagcagt 2891461 aattgaacag cgtttttaca taattcatgt atatcaatat gaaacgtcgt cagaggaggc 2891521 gagacatact tcgcgaagct gatgttgttg atactcacaa tgcttaccct gtttggtatg 2891581 gcaattcctt tttcgttcag ggcttgcaga cagcccactg caatcgggtc cgctgcaatc 2891641 ataaaagcag tcggaagctg atcgcctaat gtgtcgatcg ctgctgacat caggcggtag 2891701 ccgttttcta cagagaatcc gcgatgacag aaaatatagc gctcgtccag catggctttt 2891761 tccctcatat aggatctgaa ggtttgttca cggatgtcca tttcatcctg attggtattc 2891821 ggatttttgt atgtgccgcc gataaaaccg atgctcttat gccccttctc agtcaggatg 2891881 tttaccgtct tccttgtcat ttgtgccaaa tcgggcctta ccgagtcaaa atgatcggga 2891941 tcaggagttg aatcgatgaa cacgccgttt tcagtgagat ttctgaggaa agccagctct 2892001 tcatctgaaa atgtgccgac ggcaataaac ccttccgtat gttcaggaat gctctcgatt 2892061 ccatccgcta ttttataagt ggtcatatcg acattgaatg ctttcgccag tttctctact 2892121 tctaatctca tcgttttaaa atagacatct tctaattctt ctttatctgt cagccaatat 2892181 aaaaacgcaa tatgtttcac cagcggcctt actgtttttt tgcggtaatt gagcttttcc 2892241 gccgcttcat agattttctc ccgtgtctca tcaggaacag aaaggctttc atcgttattt 2892301 aaaacgcggg aaacggttga gattgaaaat cccgcttcct gcgcgatatc tttaattgtc 2892361 gccattgtat ctgcctccat tattcagctc gcattgtttt agtaaaatat tttactttct 2892421 ttttcacaaa tgtcaagtgc acaaagccct ctggctgcca tgtaaaaaga ctgaaccatt 2892481 tgcggctcag tctcagttgt tcgtatcatt cggaaccggc ggaattgccc gggaaatgag 2892541 ttggttattg cacattttcc tcgaaatatc ccgaaagcac atcttccaca ttcgtcaaat 2892601 gcgccagcat ggcggcttcc gcctgtgcac cgttcccggc agccacagca ttgtaaatcc 2892661 gttcgtgctc ctcatacagc cgctgaacgg aggtcttctt ggaaaacagc cagattttcc 2892721 tcgtttccct cattgtttcc agcagcaatg atgacacgtg attcatcaag tgtttaagaa 2892781 gttcattttg agaagcgtcc gcaagcgcaa gatgaaatgc aaagtctgct ttctctccca 2892841 gctccccgtc cgcttcaatg ctgcccattt cctttagtgc atcctgaatt ctttcgagat 2892901 ctgcttctgt ccttttttca gccgctagtg aagccacgcc gatttcaagc agttttctga 2892961 cctcgagcag ctgcttgacg tcctcttttt tcatcagaag ggcggctgag agcggctgag 2893021 aaatttgatt gagctcaaat tccttcagat acgtgccttc tccctgtttc atttcgacaa 2893081 gccccatcgc ttttagcgca gaaagtgctt cgcgaaccgc tgaacggctg acttgaaagc 2893141 tctcagcaag cgcctgaaca gagtccagtt tatcccccgg cttcaattcg ccatttttga 2893201 tcatatctaa tagggcatcc gctacttctt catatatttt tttgttttaa tctgtttata 2893261 tttcaatgca attcaccccg taacttgtag gtctggctgt ttacgatcta ttatactctg 2893321 ttttgtgggc cgccaaaaga ttttgactat tttgtcaaaa agtcttgtac tttgattttt 2893381 ttcaaaatat aatgctaggt aactggtctt attacccagt catcagatga tcatatcatc 2893441 tatagaaacc gcttacatat ggcgccagtt tatgtttcaa ggaggggttt gggatgcaat 2893501 ggacacaggc atatacgcct atagggggaa atttgctatt atcagcgctt gccgcacttg 2893561 taccgattat tttctttttt tgggcactcg cgattaaacg gatgaagggg tatacagcag 2893621 gcttggccac attggggatc gcccttatca ttgctgtatt ggtttatcgt atgccggcgg 2893681 aaaaagcgct gatgtccgcg acacaaggag ccgtatacgg attgttgccg atcggctgga 2893741 tcattgtgac gtctgttttt ttgtataaaa tcactgtgaa aacgggacag tttgatatca 2893801 ttcgcagctc tgttctctcg attactgatg accgacggct tcaagctctc ttgatcgctt 2893861 tttcattcgg ggctttttta gaaggggcag caggcttcgg agcgccggtc gccatttctg 2893921 ccgcgctgct ggtcggtctc ggctttaatc ctctttatgc tgcggggatc tgtttgatcg 2893981 ccaatacggc gccggttgcc tttggggcaa ttgggattcc aattacagcc gtagaagggc 2894041 cgacagggat tccggcgatg gagatttcgc aaatggttgg gcggcagctg ccgtttttat 2894101 ccgtatttat tcctctttat ttaatcatca tcatgagcgg gttcaggaaa gccttggaga 2894161 tctggccggc gattctcgta tccggtgttt cctttgctgt tgttcaatat ctcagttcca 2894221 attttttagg gcctgagctg cccgatgttt tgtcagctct tgtttcaatg gctgcgcttg 2894281 ctgtgttttt gaaatggtgg aagccgaaaa caacattccg gtttgccggt gaacaagagt 2894341 cggccgcctc aattgaaacg gcgcgcacaa atccggcggc gcctgcatac agaggcggac 2894401 agatttttaa ggcttggtcg ccatttctgc tgctgacggc gatgatttcc gtatggggca 2894461 ttccatctgt caaatccgcg ctgaccgggc attatgaagg ctctgcggtg ttcttgaagt 2894521 ggctgaatgc tgttggagaa aaactgactt tttcccccgg tgtgcctttt ttgaacaatc 2894581 agattgtcaa tgctgacggt acgccgattg aagcggttta caagttggag gtgcttggtt 2894641 cggccggcac cgcgatattg attgccgcag tgctgtcaaa attcatcacg gcgatttcgt 2894701 ggaaagactg gggaaccgtt tttaaagaaa cagtccagga attgaagctt ccgattttga 2894761 ccattgcttc tgtcgttggt tttgcctatg tcaccaactc ctcgggaatg agcacgacac 2894821 tcgggatgac actcgcgctg acaggttcga tgtttacctt cttttcgccc gttctcggct 2894881 ggctcggcgt cttcattacc ggctcggata cttctgccaa cctgctgttc ggcaacctgc 2894941 agaaagtcac cgcattatca gtcggcatgg accccgttct gtctgtggcc gccaactctt 2895001 caggcggtgt cacaggaaaa atgatttcac cgcagtcgat agcggtggcg tgcgccgcgg 2895061 taggactcgc cggaaaggag tcagatcttt tccgctttac cattaaacac agtctgtttt 2895121 tgctgctgct cgtctgtatc atcacctttt tgcagcatca cgtattcagc tggatgattc 2895181 cttaaaaaaa tcctcccgtc tagggaggat tttatttata tcgctttctc gctgccgatg 2895241 acggaatatt catttgatcg cgatattttg ccacggtgcg tctcgagatt tggatgccgt 2895301 gttgttcata cagcaaatcg acaagctttt ggtctgaaag cggttttgtt ttgtcctctt 2895361 gattgatcag gttttccaga tgcgttttga ctgcataatt cgacgcatct ccatcacctg 2895421 aagcctcggc ttttgctgag aaaaagagtt tcatctcaaa cagcccgtaa ggcgtttgta 2895481 ttgttttccc tttaatggcc cggctcacag ttgattcatg aaggcttaga cagtctgcca 2895541 cctctctgag agtcagcggc ttcattgcgc ttcgcccttt cagaaagaaa tccttttggc 2895601 gtgtgatcag ttcattgata attctcgtga ttgtctgttt tcgctgccgc agcgcgcggc 2895661 tcagccagcg ccactcctga tatttcgcag ataaatagga gacagtatcc tgacaggagc 2895721 cggatgataa aagcgttctg tactgcggat gcagatcgat ctcgggaaac gagcgggtat 2895781 tcagttccgc tgcgatgtgc ccatttttta cggtgataaa aatgtcaggc tcaatataca 2895841 catcttgctc tggccgggca aacagaaggc caggtctagg atgaagagcc gcgatatcat 2895901 ctgagatatc ttgaatggta tgaagcggaa ttcccgtctc tactgaaagc gttttccatt 2895961 ttttttgcgc aaaagcatca aaatgagctg aaaccagcat ttccgcttgt tcatttctgt 2896021 tcggcagccg ctgtaattga agaaggatgc attcctgcaa agatctcgcg ccgattccag 2896081 ccggttctaa cgactggagt tttgccaaaa cagcctccgc ttccttggcc gatacagata 2896141 atcgccgtgc tgcctcctct atatcttctt ccaagtaccc gtttgaatca agcgaatgaa 2896201 tcagataatt aaaaatcttt ttttcagtgt ttgtcagatt catatcgagt gactgctgtt 2896261 ttaacgcatc ctgcaatgtt ttttgcggat tacttaattg aaggcccgct tcctgtgcat 2896321 tcatcctgtt tttgtttgtt ttatggtaag atagtggcgg tgtgtctgtt tcctttcgtt 2896381 caataagagg gttttccagt gagagctcat caatgtactc ggcgagttct gccgaatgat 2896441 agccaagcag cgtgatggcc tgcctgagct cctgtgtcag ttgaggcttt aatacttgta 2896501 cttgctgaag tttcatatcc atcttgctca ctcccctttc ttcattgtac atgattgaga 2896561 tcacaccgta tacatttatg aaaaaggagc tgccaaagaa atgtctgaac ttttttccgt 2896621 cccttatttt attgagaatt taaaacagca tattgaaatg aatcagtctg aggataaaat 2896681 ccacgcgatg aacagctact accgttccgt cgtctcaaca ctagtgcagg accagctgac 2896741 gaaaaacgca gttgtcctga aacggattca gcatttagat gaagcataca acaaagtcaa 2896801 acgtggagaa tcaaaataaa ccttccgaat tcgggaagat gatgatcggt taaagggcta 2896861 acgttcgcat ctatagggga aatctgttta taatggggga aaaagggaga gaacacaatg 2896921 actcatcaaa tagtaacgac tcaatacggc aaagtaaaag gcacaacgga aaacggcgta 2896981 cataagtgga aaggcatccc ctatgccaag ccgcctgtcg gacaatggcg ttttaaagca 2897041 cctgagccgc ctgaagtgtg ggaagatgtg cttgatgcca cagcgtacgg ctctatttgc 2897101 ccgcagccgt ctgatttgct gtcactttcg tatactgagc tgccccgcca gtccgaggat 2897161 tgcttgtatg tcaatgtatt tgcgcctgac accccaagta aaaatcttcc tgtcatggtg 2897221 tggattcacg gaggcgcttt ttatctagga gcgggcagtg agccattgta tgacggatca 2897281 aaacttgcgg cacagggaga agtcattgtc gttacattga actatcggct ggggccgttt 2897341 ggctttttgc acttgtcttc atttaatgag gcgtattctg ataaccttgg gcttttagac 2897401 caagccgccg cgctgaaatg ggtgcgagag aatatttcag cgtttggcgg tgatcccgat 2897461 aacgtaacag tatttggaga atccgccggc gggatgagca ttgccgcgct gcttgctatg 2897521 cctgcggcaa aaggcctgtt ccagaaagca atcatggaaa gcggcgcttc tcgaacgatg 2897581 acgaaagaac aagcggcgag cacctcggca gcctttttac aggtccttgg gattaacgag 2897641 ggccaactgg ataaattgca tacggtttct gcggaagatt tgctaaaagc ggctgatcag 2897701 cttcggattg cagaaaaaga aaatatcttt cagctgttct tccagcccgc ccttgatccg 2897761 aaaacgctgc ctgaagaacc agaaaaagcg atcgcagaag gggctgcttc cggtattccg 2897821 ctattaattg gaacaacccg tgatgaagga tatttatttt tcaccccgga ttcagacgtt 2897881 cattctcagg aaacgcttga tgcagcgctc gagtatttac tagggaagcc gctggcagag 2897941 aaagttgccg atttgtatcc gcgttctctg gaaagccaaa ttcatatgat gactgattta 2898001 ttattttggc gccctgccgt cgcctatgca tccgcacagt ctcattacgc ccctgtctgg 2898061 atgtacaggt tcgattggca cccgaagaag ccgccgtaca ataaagcgtt tcacgcatta 2898121 gagcttcctt ttgtctttgg aaatctggac ggattggaac gaatggcaaa agcggagatt 2898181 acggatgagg tgaaacagct ttctcacacg atacaatcag cgtggatcac gttcgccaaa 2898241 acaggaaacc caagcaccga agctgtgaat tggcctgcgt atcatgaaga aacgagagag 2898301 acgctgattt tagactcaga gattacgatc gaaaacgatc ccgaatctga aaaaaggcag 2898361 aagctattcc cttcaaaagg agaataaata tggggaaaac aggatacatt ggtgctgcca 2898421 ttgttgtggc agcttgtatc attattttgt cggccgtggt atgtttacgg gacacagtct 2898481 attaccagcc tatgcgctgg actggcatca tactgttttt cgcgggaatt gtgatggttc 2898541 ccgcatactc agcaaaaaga aaacccggaa aagagaagta attctctttt ccgggttttt 2898601 atgtttatta taatcttccc gcgcgaatat cgtctgtcat tccctcataa ggagccttcg 2898661 aaatcacttc ttcgttgtcg actccttcat ttttcagaaa tgtaatttcc gcaaattcag 2898721 gtacaacgta ttttggatac gtttcatatt tttcgcggga ttctttcatc aaatcaatgt 2898781 ggtcattttg gtagcaaacc gtaatttcag gatgttcatg cacccatttc gggaagaaaa 2898841 taatgccatg catgcgtttt tcatttggca taaagtttaa tgaaacatcc gtgccagtcg 2898901 gctctgtcca agacacttta tatacgcctt ctgtcagttt gacaatattc acttcctgat 2898961 ctcgaaccca gcgtccggca accattccgc tatgaattct ataatcaatt gtatggtcgt 2899021 ttttaatata aatctcgtat tcccatccgt tttcatacgt ataaatcatg tggcttccga 2899081 taaagttttc catcttacac actctcctta gtcttttact gtacttcata aatgtctagt 2899141 agaacgtaat caggggttct ttctgcggaa ccgataaaca agcggtcatg gagccattga 2899201 tagacttcac tgcctgtttc aaacgtcggt accgtacgaa aataaacatg ctccggttca 2899261 ataatttccc cggctgccgc ttgttttcga aacggcttgc tgacttgccg tattccattg 2899321 ttttcaatgt aaatcagttc atgatctgct gtttcaatca catacctggc agataaatct 2899381 gttctgccgt tagcgcgaat catttgtgaa tcggcaccgc ccggcaaaat acgtcccttt 2899441 acttccccgg ttattgttcc cgaacgaatc ggaatgaatc atctcagtcc caggcttgtc 2899501 tcaccaatcg tgataggcgg atcaaccttg atttctaaag aggcgaatgg ttttaaaacc 2899561 ggcttcttca cgagaaccac ctcaccttca gaaaaaatca tgtaactatt tacatgttca 2899621 ctttaacacc attgcagtta actgtcaaac aataggaaca taaaaaaaca aggactgttt 2899681 gaagacagtc cttgtctgaa gctagctttg ataagcaaga tatgtgctga cagtgctttt 2899741 ggcaagacag gcagaggaat ctataatcgg aatctcactt tgaatatgat ctaacaccgc 2899801 atttaaatcc gtgcaggctg aaatgatgat gtctgcatgc tgactgattt cttcatatag 2899861 cgtctgccac aatgcttgtg tatgctgcat atgatttggc tgtttgattg cggcgataag 2899921 ctggttcaca gcctgctgcc aatggtcctt gtgaataact tcttgtccat ttcccttcag 2899981 aactttttgg tagatggcgg attggatggt tggctctgtt cctaaaacca ccgctttttt 2900041 tgcgggatgc ggaatctctt ttatcgtttc ctcaacaata tgcaacatag gaactgacaa 2900101 tgcctgctga atctcttcat agtagacatg cgccgtatta caaggcagcg caatgaaatc 2900161 cacgcctgtt ttctcgagct ttaccgctcc gtcgataatc gcttttttca tctcgtcatg 2900221 gtcaattgga cgatctgcat agaagggcgt cgggcatgaa tagatcatca tgtgcggata 2900281 gtcaatatcg tttgaagccc catacagctt ctgacagtaa tcaatcacct tatcaataaa 2900341 cggcgaggtc gatttcggcc ccattccggc taatattccg atcatcaaat tcattccttt 2900401 ctacttcgta cggaccgctt cttcctctga gccatcctca tagaggataa agcttttcgc 2900461 agcatcctca cctaatgtaa actcgacttc aacagacaat gctcgcagaa agaaacgggt 2900521 ttccgaggaa ggaaataact ccagtctcag ctgtccggcg atctccaaat aaagccgttc 2900581 attctcggtt gtcacctgtg cagccgtccc atcctgcaac aggtagctgc caacatagcg 2900641 gctgtatatc gccgtatcaa ttgctttttt ctttttatca gcaggacgtt ccgggacatc 2900701 atatggctgg ccaaatagaa tatgttccgc cgccttcaga atcgcttgtt catattcagt 2900761 atcctcttcc ttattactca aatagatcag cgttttacga tgatcgatat atcggatcat 2900821 catcgtcgaa tagccgggcc atcctccgct gtggctgaca atccgccctt tttcaggact 2900881 gttttgcagc acccagccaa agccataatc aattgtttct ccattgttga ggcgcactgg 2900941 agaaaacgca gattccttag aagccttgct gatgaaatcg tcctgatata aagcctgatc 2901001 aaatcgaaac aaatcgcttg tgacagagtt aaccgtccca tctccctgta tgccatcgag 2901061 atacacaaca tagttcgttt cctccagctc atcagggagg acgtatgttt cggaatgtac 2901121 atcatacaca tatccatatg cataatgatc aattcgctca ggcgaaagcc tcctgttata 2901181 cactcttgtt tcattcatgc ctgccggtaa aaaaatactt gtttttataa aatccgcata 2901241 gctcatgcca gatgcttttt caatgataac cgccagcagc acataccccg tattgctgta 2901301 catccagcct tcattcggtt caaaataacc agatagcccc tcattcatca gcatatcgac 2901361 aatatcctga ttcaccgcaa tcttgtgtga atcccaattg gcaaaaaacc atcccatata 2901421 atcaggaagc cctgacgtat ggttcaataa atgccgaatc gttacgccct gatacggaaa 2901481 accgggcagc cagcgatcca ctttatcctc atagccaaga atccccttct cctccagcaa 2901541 gatgattccc aatgctgtaa aaggctttga caaagacgct aactcaaaca aagagttggt 2901601 tttcaacggg cgtttttccg tcatttccgc atagccaaaa gagtggtgat ataaaatatc 2901661 gccaccctcc gcagccagaa ccgtcccgtt aaactgatgt ttttcgccta atgtctcaaa 2901721 taacgtctga agatgctttc ttttattctg cttcattcct ccacctccca tatctctgta 2901781 cgttactaac ctactaacgt ttcaaatatt ttgaaaaatc cttcagttag agatcctttt 2901841 taacccatca catatacctg ccgttcacta ttatttagtg aaatgagata ttatgatatt 2901901 ttctgaattg tgattaaaaa ggcaacttta tgcccatgca acagaaacta taaaaaatac 2901961 agagaatgaa aagaaacaga tagatttttt agttctttag gcccgtagtc tgcaaatcct 2902021 tttatgattt tctatcaaac aaaagaggaa aatagaccag ttgcaatcca aacgagagtc 2902081 taatagaatg aggtcgaaaa gtaaatcgcg cgggtttgtt actgataaag caggcaagac 2902141 ctaaaatgtg taaagggcaa agtgtatact ttggcgtcac cccttacata ttttaggtct 2902201 ttttttattg tgcgtaacta acttgccatc ttcaaacagg agggctggaa gaagcagacc 2902261 gctaacacag tacataaaaa aggagacatg aacgatgaac atcaaaaagt ttgcaaaaca 2902321 agcaacagta ttaaccttta ctaccgcact gctggcagga ggcgcaactc aagcgtttgc 2902381 gaaagaaacg aaccaaaagc catataagga aacatacggc atttcccata ttacacgcca 2902441 tgatatgctg caaatccctg aacagcaaaa aaatgaaaaa tatcaagttc ctgaattcga 2902501 ttcgtccaca attaaaaata tctcttctgc aaaaggcctg gacgtttggg acagctggcc 2902561 attacaaaac gctgacggca ctgtcgcaaa ctatcacggc taccacatcg tctttgcatt 2902621 agccggagat cctaaaaatg cggatgacac atcgatttac atgttctatc aaaaagtcgg 2902681 cgaaacttct attgacagct ggaaaaacgc tggccgcgtc tttaaagaca gcgacaaatt 2902741 cgatgcaaat gattctatcc taaaagacca aacacaagaa tggtcaggtt cagccacatt 2902801 tacatctgac ggaaaaatcc gtttattcta cactgatttc tccggtaaac attacggcaa 2902861 acaaacactg acaactgcac aagttaacgt atcagcatca gacagctctt tgaacatcaa 2902921 cggtgtagag gattataaat caatctttga cggtgacgga aaaacgtatc aaaatgtaca 2902981 gcagttcatc gatgaaggca actacagctc aggcgacaac catacgctga gagatcctca 2903041 ctacgtagaa gataaaggcc acaaatactt agtatttgaa gcaaacactg gaactgaaga 2903101 tggctaccaa ggcgaagaat ctttatttaa caaagcatac tatggcaaaa gcacatcatt 2903161 cttccgtcaa gaaagtcaaa aacttctgca aagcgataaa aaacgcacgg ctgagttagc 2903221 aaacggcgct ctcggtatga ttgagctaaa cgatgattac acactgaaaa aagtgatgaa 2903281 accgctgatt gcatctaaca cagtaacaga tgaaattgaa cgcgcgaacg tctttaaaat 2903341 gaacggcaaa tggtacctgt tcactgactc ccgcggatca aaaatgacga ttgacggcat 2903401 tacgtctaac gatatttaca tgcttggtta tgtttctaat tctttaactg gcccatacaa 2903461 gccgctgaac aaaactggcc ttgtgttaaa aatggatctt gatcctaacg atgtaacctt 2903521 tacttactca cacttcgctg tacctcaagc gaaaggaaac aatgtcgtga ttacaagcta 2903581 tatgacaaac agaggattct acgcagacaa acaatcaacg tttgcgccaa gcttcctgct 2903641 gaacatcaaa ggcaagaaaa catctgttgt caaagacagc atccttgaac aaggacaatt 2903701 aacagttaac aaataaaaac gcaaaagaaa atgccgatat cctattggca ttttctttta 2903761 tttcttatca acataaaggt gaatcccata tgaactatat aaaagcaggc aaatggctaa 2903821 ccgtattcct aaccttttta ggaatattgc tgtttatcga cttatttcca aaagaagaac 2903881 atgaccaaaa aacaaaatca aaacagaagc cggactaccg ggcggcatat cattttacga 2903941 cgccggataa atggaaaaat gaccctcaaa aaccgatcta ttttgatggc aagtatcatt 2904001 atttctatct atataaccgg gattacccaa aaggcaacgg cacagaatgg cgccatgccg 2904061 tctcagagga tttggtgcac tggaccgatg aaggcgtggc gattccgaaa tatacaaacc 2904121 cggacggtga tatttggacc ggttccgtcg tggtggataa agagaacaca gccggcttcg 2904181 ggaaaaatgc gcttgtcgcg attgtgacac agccctcagc caaagacaaa aaacaggaac 2904241 aatatttgtg gtacagcaca gataagggaa aatcattcaa attctacagt ggcaaccccg 2904301 ttatgcctaa tccgggcaca gacgatttca gagatccgaa agtcatatgg gatgaccaag 2904361 ataacaaatg ggtcatggtc atggctgaag gatcaaaaat cggcttttat gaatccgata 2904421 atcttaagga ctggcattac acaagcggat tcttcccaga acaggcggga atggtggaat 2904481 gtcccgacct ctacatgatg cgggcaagcg acggaacgaa taagtgggtt ctcggtgcca 2904541 gcgcgaatgg caaaccgtgg ggcaaaccaa atacgtacgc ctactggacc ggaagcttcg 2904601 acggaaaaga attcaaagcg gatcagactg aagcccaatg gcttgactat ggcttcgact 2904661 ggtatggcgg tgtgacgttc gaagacagca aaagcacaga tccattagaa aagcggtatg 2904721 cgcttgcctg gatgaacaat tgggattatg ccaacaacac cccgacaatg aagaacggct 2904781 ttaacggcac agattctgtc atacgcgaac tccggctgaa ggagcaggat ggaacataca 2904841 gcctcgtctc acagccgatt gaagctttgg agcagctgac tgtttcaact gacgaaatag 2904901 aggatcagga tgtgaacgga tcaaaaacat tgtcgataac aggtgatacg taccagcttg 2904961 atacggatct ttcttggtca gagctaaaga atgcaggcgt caggctcaga gaatcagaag 2905021 accaaaaacg ccatattgat gtcggcattt tcgctgaagg cggctatgct tatgtcaata 2905081 gagcagccac aaatcagcct gacaaaagca atacctatgt cgaaagcaaa gctccttatg 2905141 atgtaaacaa acgtaaggtg catttgaaaa tacttgtcga taaaacaacg atagaagtat 2905201 ttgttggcga cgggaaaacc gttttttcaa atgaagtctt cccaaagcct gaagataaag 2905261 gaattaccct ttattctgac ggcggcacag cctccttcaa aaatataaca gtgaaacact 2905321 ttgattcgat tcatgaataa aaacaggggc ggcgcaggct gcccctgttt ttttattagg 2905381 agcggtattc tctgttacat attgggcatt gtaaggaata taaggctggt ttcaaaggag 2905441 gaagcgaatg tctaaacaag gaaattttca aaaatcaatg tcgctgtttg atctgatttt 2905501 gattgggatg ggagccatct ttggatcagc gtggctgttc gctgtcagta atgtcgcttc 2905561 aaaagcaggg ccctccggcg ctttttcctg gatcctcgga ggagccatta ttttgttaat 2905621 cgggcttgta tatgcggagc tcggagccgc tctgccccgt accggaggca tcattcgata 2905681 ccccgtttat tcacatggcc accttgtcgg ctacttaatt tcgtttgtca cgattgtcgc 2905741 ttatacaagc ttgatttcaa ttgaagtgac agctgtgcgc cagtatgtgg cctattggtt 2905801 tcccggcctg accattaaag ggtctgattc gcctaccatt tccggctgga tcttgcagtt 2905861 tgccctatta tgcttgtttt tcctgctgaa ttattggagc gtcaaaacct tcgctaaggc 2905921 gaatttcatc atatcgattt ttaaatatat tgtgccgatt accatcatta ttgtgctgat 2905981 ctttcatttt cagccggaga atttatccgt tcaaggattt gcaccgtttg gatttacagg 2906041 tattcaggct gccatctcga caggcggcgt catgtttgcg tatctcggcc tgcatccgat 2906101 tgtatctgta gcaggtgaag tccaaaatcc aaaacgcaat atcccgatcg ctttaatcat 2906161 ttgcatcatc gtttcaacca tcatttatac tgttttgcag gtcaccttta ttggtgcaat 2906221 cccgacagaa acactgaaac atggctggcc ggcaattggc cgggagttct cattgccgtt 2906281 taaggatatt gcggtcatgc tcgggttagg ctggcttgca acgcttgtca ttttagacgc 2906341 cattctgtct cccggaggaa acgggaatat ctttatgaat acgacatccc gccttgttta 2906401 cgcctgggcg cgtaacggca cattatttgg catattctca aaggtcaata aagatacggg 2906461 gacaccccgc gcttcgcttt ggctttcgtt tgccctgtcc attttctgga cacttccctt 2906521 tccttcgtgg aacgcgctcg tcaatgtctg ttcagtcgcg ctcattcttt catatgcgat 2906581 tgcacccatt tcttcagctg cgctgagggt caacgcgaag gacttaaaca ggccgtttta 2906641 tttaaaggga atgagcatta tcgggccgct ttcctttata tttacagcgt ttatcgtgta 2906701 ctggtcagga tggaaaacag tctcctggct gctcggttca caactcgtga tgtttttgat 2906761 ctatctctgt ttcagcaaat atacgcctaa agaagatgtc agccttgctc agcagctgaa 2906821 atcagcctgg tggcttatcg ggttttatat tatgatgctg atcttttcct acatcggttc 2906881 tttcggacat ggtttaggga ttatcagcaa tcccgtcgac ctcattttag tcgcgatcgg 2906941 ctcacttgcg atttattact gggcaaagta taccgggctc ccaaaagccg ccattgatta 2907001 tgataaataa agaagcaaga ggttttcttg cttctttatt ctttacaaac aaacatacac 2907061 gcgataaaat gaatgagagt cagtcattac tggaggtgtt cctcatgcca aaacaaacat 2907121 cgggtaaata cgaaaaaata ttgcaggcgg ccatagaagt catttctgaa aaaggcctcg 2907181 acaaagcttc tatttctgat attgtcaaaa aggccggcac tgcccaagga acattctatt 2907241 tgtatttttc atctaaaaat gccctcatac cggccattgc agaaaatctc ctcacccata 2907301 cacttgatca aatcaaaggt aggctccatg gggacgagga tttttggacc gttttagata 2907361 tattaattga tgagacattt ctcattacag aacgccataa ggatattatt gtcctctgtt 2907421 attccgggct tgcgatcgac cactccatgg aaaaatggga gacgatctat cagccttatt 2907481 attcctggct tgaaaaaatc atcaacaagg ccattgcaaa ccatgaggta acggaaggaa 2907541 tcaattcaaa atggacggcc agaacgatta tcaacttggt cgagaatact gcggaacgat 2907601 tctatatcgg atttgaacaa gatgaaaatg ttgaagtgta taaaaaggaa attttcactt 2907661 tcttaaaacg gagcttaggt actgcttaaa aaatgactgg gtaacaccgc tcatttttta 2907721 atgccctaaa aatgactgac gttcattcat aaaatagaga ggtgtttcat ttgaattggg 2907781 ttcttgtttt tattgcaggg cttttagagg ttgtttgggc ctcttccctc aaacatgccg 2907841 attcgctttt ggattggatc atcattttta tcttaatcgc ggtcagcttt atcctgttga 2907901 tccgctctta tcaaaaaatc ccgatggccg cggcgtacac tgtgtttgtg ggaatcggaa 2907961 ccgtcggaac atatctgact ggaattgttc tgggcgaatc cttctcagca gcccaaatgt 2908021 tctttttagc tttattgctg gctggcattt taggaatgaa attatttacg aaagaaagca 2908081 aatctcagcc gggaggtgaa aaataatggc atggttttta ttagtgattg ccggcataga 2908141 agaaattata gctgccattg ccatgaaata tatagacgga acaagaaaaa aatggccgat 2908201 cattgtgatg actgttggat tcggcttatc cttttactgc ctgtcccaag cgatgatcgt 2908261 cctgcctgcc ggagtcgcat atgccgtctg gactggcatt ggaagcattg gtgtttcggc 2908321 ggtcgggctc atctggttta aggagcggtt tcagctttca caggtgattt cactttgcct 2908381 tatcctagcc ggcgtcatcg gcctgcgtct tacgtcatct tcataaaatc aaggcatata 2908441 cagctgtata tgcctttgcc attaagcttc gtgatgtttt tgaagatgaa gcggcggcgg 2908501 gatgagccag cctttgtttt ttagcagcct taagtatttt gcgccggttg ccgctttcga 2908561 catatgaaat tgcccaaaca tcatggcaat atcctcacga atcgattgcc ccatcatttt 2908621 gctgcatgtc acaagacctg cagcattttc tgctgccgcg gaagccgcca catccggatc 2908681 gagaaaccgt gcaccaggcg gaatatcgtt aagatctgct gtcggcggtt caggagaagc 2908741 cggcggcagc gccaccccgt tttctttcag gatcgtgctg acctgtttga tttcatcttg 2908801 gcatttctca atagactcac gaagcagctt cttcaggtcg tcatcaccga catgattcaa 2908861 tagcatttgg taattgccga ccattttatt gcccgccatc acataactcc acaagccgaa 2908921 tacctcaccg taatgcatcg gttcatcctg cggatttccg cttaaaatac ccatgctcat 2908981 tctcctccca tattcaatat tgcacatttc ataacgtgcc caagcggagg aacatttatg 2909041 tttcagcgga aaagatttat gaaatgaaac aaaacaaaaa agacaagagt ggcaagttgc 2909101 caaaccattg tctttcctgt tgtttgattg gacgcactga agggattcgc accccgacag 2909161 acaagatacc ggaaaccatt caagtgcttt ttagtatgag tcattgattc tgtctttaat 2909221 aaactttaac gagatggcgg gatgctttgc ggaaaacgaa atacattttc ggggtcatat 2909281 ttcgccttta tttctcgaag ccgcgcaaag tttgcgccat aatattcttt tccgaagttt 2909341 tcaatgtttt gatctggaac attaacatat gaacctgcta catatggttg catcagctga 2909401 cgcactcttt caactgatgc aagatttgaa tcttcttgtg atttattttt ccaactagcc 2909461 gtccattccg tataaaataa tggatggcgc caaaaaaagg cagtttcgtc tttagggact 2909521 ctgcttatag caccacccca attgataaaa aagaaattgg cttctgttcc agtagcatct 2909581 tccaaaaatt ttctcatgat tgaaatgggt tcgtcagacc aaaaatcatg accccatgcc 2909641 gaggagaatt taacactctg atcatttctg ccagggatgg gttcgtcagg gtctaagaaa 2909701 tctatagcat ctggatagta taatgttttg atatctgctt ctgttggagt tcccgcatgt 2909761 aataaaggtt ttaataatcg aatcaattca gttttcgaac cgaggaaaat tccttctgca 2909821 tgacacaaac catttatttt gctgtaaatt tcaaggtagc atcctaatcg ttcatctaca 2909881 aacggagccc atttctgcca agctttaaat accgtttcta attgttccca cggccagata 2909941 atattgaaga cggttgcagt tttaggggca cgatgaactt tgaatgtata ttgggtatta 2910001 tatccaaagt tacctcctcc tccgcctcta gaagcccata gcaaatcctc attgtgagat 2910061 tgatctgcgt gaataatcct tccttttgca tctaccgttt tcagcgcgag aaggttatca 2910121 cttataaggc caatcgatcg tgagagtaca ccaaatccgc cgcccatcgt aattcccccg 2910181 attccaactg ttgggctatc tccaaacgga gccataaaac cgtctcgagc taatcccttt 2910241 acaagcgggc caacgggaat accagtttga acggttgcaa tagcgttttc ttcatctaag 2910301 aaaactttat tcatgtcact cacatcaata acaattcctc cacttactac tgaaaggttc 2910361 ttatctaaag catggcgacc gcttctgaca cgtaagggca ctttattctc acgagcccat 2910421 ttaatggcat tacttacatc gtatgaattt tgcgcaaaaa caaagacaag aggatagaca 2910481 tccacataag ggttccaatt cttaatagcc tctgtatagc cggggtctcc tttgaagatt 2910541 acacgccctg tcaactgtgt tgatcccata tattatttca ctcccaaaga aattcgattc 2910601 agatactaaa atatgcagga gctggataat cgcatagaca aatgatctac gaactataaa 2910661 tataatacgc taaggccttt ttcgtcggtg aggtctgctg agaaacattt ttcaaacaat 2910721 tttgagcaaa cttcctgtcc aatcctccaa caagcgtttt ttcttatcgt ttttaggagc 2910781 agtgtccagt ttttttcgga gtgaatattc gtttaggcca aaagaaaaga gagatgaaga 2910841 agtgtttagt accagaggta tacatccata caacagactc tagatcatca tatactgaat 2910901 gtatgtagaa aggagacatc agctttggca aaatatcgga ttatgacctt tgacggcggc 2910961 ggtaccttag gtgctttaag tttacaacta ttaaacagat tggctaggca aaacccgaag 2911021 ttaattagtc gaacccatgt attttcggga aattcaatcg gttcatttac tgcccttgca 2911081 ttagcaagcg gaagatctcc gagggaaaca cttcagtatt ttgaggatga aatcctaccc 2911141 gcattcagca tttcccggcc aggcggacct gttttcaacc aacaattacc ctattccggt 2911201 tttattaaag cggtaagaaa ttttttccca gcagatcttc aacttataga tttaagaaaa 2911261 cgaattgttg tcccatcatt caaattatac tctcaaaaac tggaccgttg gactcctgtc 2911321 ttatttcaca attttcccgg ctctccctat ttaaatgaaa aagtgagtga tgtcatactg 2911381 cggagcagcg gtgctcccgc gacgcaacgc gcctatcaaa actatgtgga cggatatgta 2911441 gtagcaacga atcccagtac agccagtatc gcgtttgcag ttggtaaagc caacgtgcca 2911501 ttggatcaaa ttgcggtatt gtccatcgga acaggtgaag ccccgactcg gttaagaaga 2911561 gatacgaggg gatggggaat ggtaagtgca gataacatac gtcccgaaaa tctgaagaac 2911621 cttcctccaa attggggagt ccttttggac aggtcgccta atgaaccttt actgccattt 2911681 cttcagatga ttgctggcgg taatgggtac tatgaatcca tggtcagtgc gaatcttctg 2911741 ggagatcgtt ttttccggtt agatccgcgg attccgaact tctccaaaac ggaccctgcc 2911801 gtcgttcccg ctgtcattga aattgcgaac aaaacaaact tacagcctgc gaatcaattt 2911861 atagagaaga actgggggag caaataatta tttattttaa atcaattctc gcttatacaa 2911921 ttttgtccga gagaagattc tcaaaataaa tacaggcaat gggtagaacc ggattttttt 2911981 aaaggtttgt taatcacaag ctaataagat gaatgaaaaa atcaattcat acttcttctt 2912041 ttgaaagtga gggttcaaac taaagaatgt aattgaaatg ttactctaag gtatgcaatt 2912101 ccctttttca cacaaaaaaa gacaagagcg gcaaatcgcc aaacccttgt ctttcctgtt 2912161 gttctattgg acgcgctcgg agggattcga acccccgaca gacgtggtac cggaaaccac 2912221 cgctctatcc aactgagcta cgagcgcata tagactgcgt tatgagaacg tcagcacaac 2912281 taattatacg ataattcctt tcaaataaca accctctatt tcgagaggcc gttttttaaa 2912341 tagacaaagc atcttaattg gcaatctgac atacgatggt ttgaacccct gtatttttgg 2912401 ggaaaatggg aaaaagagac gactttgcat atcaggccag ctttttgttt gacctttatt 2912461 gaccaaaaat gtatcatgta actacatact tacctaaaag gtgaaggagg agcattatga 2912521 atttaatacc tacagtcatt gaacaaacga accgcgggga aagagcgtat gacatttatt 2912581 ctcgtctatt aaaggatcgt atcatcatgc ttggatctgc gattgatgac aacgttgcga 2912641 actccatcgt gtcacagctt ttattcttag cagcagaaga ccctgaaaaa gaaatttctc 2912701 tttacatcaa cagcccgggc ggctctatta cagccggtat ggcgatctat gataccatgc 2912761 agtttattaa gccgaaggta tctacaattt gtatcggtat ggctgcgtca atgggcgcgt 2912821 tcctgcttgc agccggcgaa aaaggcaaac gctatgcgct tccaaacagt gaagtcatga 2912881 ttcaccagcc tcttggcggt gcgcaaggtc aagcgacaga aattgaaatt gctgcgaaac 2912941 gcattctctt gcttcgcgac aaattaaaca aagtcctagc tgaacgtact ggccagccgc 2913001 ttgaagtgat cgaacgcgac acagaccgtg ataacttcaa gtctgctgaa gaagcgcttg 2913061 aatacggcct gattgacaaa attttgactc acacagaaga caaaaagtaa taacacaacc 2913121 tgcaagagct gcgtctcttg caggtttttt tcatttcaag gaattgactc ccttattcta 2913181 tactgctccc attcctcatg taacagctca agcgtcaaat cactcgtctg cctcacaacc 2913241 agatcagcac caagcatcgg ctgtccttga ccgacaccaa ccgcaaacat ccccgcagat 2913301 ttgattgcag aaatgcctgc ttctgcgtct tctattgccg cgcaatcagc aggggaaaca 2913361 tcgagcatcg ctgcagctgt taaaaagatg tcaggatcag gcttcccctt cgcaagagtc 2913421 gtcggatcaa caatggcatg aaaatcatcg ataattgcca agcgtcttaa aatcttagga 2913481 gcattgcgac ttgaagatgc taacccgatt tttatatttt cgtttttcaa ttgacataga 2913541 agcctgccaa tccccggtaa aagatcttcc ggcgtcaatt tgctgatcag catttgataa 2913601 tcgcgatttt tccgatgcat aagctcttgt ttctccgcat ttgtatactt tgtttccgcc 2913661 ccgccaaaga tcaatatgct ttcaagtgac tcttctctgc tgattccttt tagcctttca 2913721 ttcatgtctc tgtcaaaagg gatatcgatt tgttctgcga tgtgcttcca agcgagaaaa 2913781 tgatattcag cagtatctgt tatcactccg tctaaatcaa aaatgaccgc tttcatatac 2913841 taatgcccat cacagcttca taaggtttga ggctaatact ctttaagtca gcccgctcct 2913901 gcggatagtt tgaaattagc actttccaac gctcatgaat cagttctgga ggcgcttcga 2913961 acagagcctt ttcttccgat aaattcacaa cgacaagaag cttttcccct cgatattctc 2914021 gaaggtaaga aaagacctgc ggatcattct cctgcaacag ctgataatcg ccatatatca 2914081 taatcttata ttgctttcgt aattgaatga gcttctgata gtaaaagaaa atcgaatctt 2914141 gatcttccaa agactctttc acattgatat cttgatagcg ggaatttacc ggtatccacg 2914201 ggtctccggc tgtgaatccc gcatgttttc cggcatccca ctgcatcggt gttctcgcat 2914261 gatcccttcc ttttatcatc acggctttga caaactcttt ttctgacatc gttttgtttt 2914321 cgacgactag ttcacgatat gcattcttta tttcaagatc atcatacatc tccagcggca 2914381 tatcgctgtt gaccatgccg atttcttctc cctggtaaat aaacggcgtt cctttcatgc 2914441 cgtgcagaac cgttgcaaat gccttcgcac attccttacg cagtttcctg tcattgcccc 2914501 agcgggaaat aaccctcggc tggtcatggt tctcaaaata aagggtattc cagccgacat 2914561 tcattaaccc ggtctgccac cttgtcatcg tcttttttaa agcaatcaaa tcaaacggct 2914621 tgatctgcca tttcccattt ggcgagtttt gttctttatc aatatccata tgttcaaatg 2914681 taaagatcat attcagctct tgcctgcttg catctgtgta ctttttcgcc tcttcaatat 2914741 cagagccgtt tgcctctccg actgtcatgc agtcgtaatg agaaagcact tccctgttca 2914801 tctcttgaat aaactcatga agacgtgggc cgttagagtg ataacggccg acaatatagc 2914861 tgcggctgtg atccgtttcg tagtccggaa aatcggtgta tttagaaata gagccaatca 2914921 catccatccg ccagccgtca acgcctctat ccatccagaa tctcattaca tcataaactt 2914981 cccggcgaac ggcttcgttt tcccaattta aatcaggctg ttttttcgaa aagtagtgca 2915041 aataatactg ccctgttcct tcatcgtatg tccacgctga gcctgaaaag atcgatcccc 2915101 aattattcgg ctctgagccg tccggtttag gatctttcca aagataataa tcccggtaag 2915161 gattgtcctt cgacttgcgg ctttcagcaa accaagcatg ctcatctgat gtgtggttca 2915221 cgaccaaatc catgacgatt ttcattccgc gtttatggac ttcatcaatc agctgaaaca 2915281 tatcttcatt tgtcccaaac ttttcgtaca tgtttttgta atcgctgata tcatatccgt 2915341 tgtcatcctg cggggaatca aataccgggg agagccagat gacatccgcc ccgaggtttt 2915401 tgatgtaatc cagcttttga atcacacctt gcaaatctcc gaatccatct ccattggcat 2915461 cataaaaact gcgcgggtaa atttgataaa cgacagcttc tttccaccat tcactcatta 2915521 ggcgttctcc tttcacatcg tccctgtagg acaaccggtt cctcataaac gttcatgtgc 2915581 agcggctcgc cttttacaag ctcaaaaata acgcgctttt cgtcaaccgt cacattgatt 2915641 aatcgatttc gataattgat gttgaatgaa tattcgtccc attctttcgg caaaaacgga 2915701 gcaaatgaca gcgtctcatt cgcggtgcgc atgcctgcaa agccatgaac gattgccagc 2915761 cagctacccg tcattgaagt aatatgcaag ccttcttccg tatcatgatt gtaattatca 2915821 agatcaagcc ttgctgtgcg cttatataat tcgagcgctt tcttttccag cttgagttcg 2915881 gctgcgagaa tcgcatggac agagggcgat aggcttgatt catgaacagt catcggctca 2915941 taaaattcaa aatttcgccg tttttcttcc attgtaaaac ggtcattaaa aagataaatg 2916001 ccttggagaa catctgcctg cttaataaaa ttggagcgga gaatcttgtc ccatgaccaa 2916061 ttctggtaaa gaggccgttc cgctggatct aattcgtcaa ctgtttgcag gtctttgtcc 2916121 aagaacgtgt catgctgaac gaaaatttgc agttcttcac taaatggata gtacatgtgc 2916181 tggatgattt ctctccagac ttccaattct acttcctgca catccagatg gcggcgtttc 2916241 tccgctgaga tactttcgag actttgtaga gtatactcca acgtccaagc cgcaatgaca 2916301 ttcgtatacc aattgttgtt aacgttgttt tcgtattcat tcggccctgt gacgccatgg 2916361 atcatatact tattttttcg tttcgagaag tgaacacggt cggcccaaaa tctgctgact 2916421 gccacaagta cgtctatccc gtattcttcc atatagttac ggtcgcctgt ataattgata 2916481 taattgtaga tcgcataaca gatcgcgcca ttgcggtgaa tttcttcaaa ggtgatttcc 2916541 cattcgttgt ggcattcatc acctgtgaac gtcaccatcg gataaagtgc ccccttcatc 2916601 cccaattttg cagcgtttcg tttggcagcc tccaactgat gatagcgata caaaagcagg 2916661 tttttcgtca cctccggctc ggctgtcgcc aaatacatcg gaacggcgta cgcctcagta 2916721 tcccaatatg cggcacctcc atatttctcg ccagtaaatc ctttcggccc gatattcaaa 2916781 cgggcatcgc ccccgtaata tgtcgagaat aactgaaaga tattgtagcg gattccttgt 2916841 tgaagctcct catctccttt aatctcaatg tccgcttttg cccatctttc cttccatcga 2916901 tcagtgtgcc tccgttttgc atcttcatag ccgttctcta ccacatccgc caaaagctcc 2916961 ttggctttcg ataaaagctc ttcctcccga aaatcacggg aagtcgtgac aatcacaaac 2917021 tttttcaatg atgccttcgt ttgataactg tagcgattct cgacatacat ttcagtcgtt 2917081 ttaaagcttt catggacaaa accctccgtc tcgtttgcca ttgcggctaa taccgtgaag 2917141 cgcggtgttc caaatggatt ttcgatcgtt tttgccgcta aatggccgct gtgagaatca 2917201 gcacctttcg cttcctcctg ccaaaactgt tcttggtagt tagaatcttc atttgccaca 2917261 tttccatcca ggtaaggaac aagcgtaatg acagcatctc ccgtcaagca ctccgcttca 2917321 taatgaatcg cacagagttc ttttacagca aggctaagaa accgctctga cctgattctg 2917381 acggttttat cttgaatgcg gacaacagcg cttcgccgca gaatcccctc tttcatattg 2917441 agttctacct caaataattc gattgggttt tgatggagat cgattttttc accgtcaaca 2917501 tataggccta tgcccataaa gttcatcgca ttgatcactt ttccgaaata ttctggatac 2917561 ccgtttttcc accagcctac tcgcgttttg tcggggaacc acacgcctgc aatatatgtg 2917621 ccttggtgac tgtcgcctga atagccttct tcaaaattcc ctctgacccc catatagcca 2917681 ttggcaagag acgtcaggct ttccagcagc cgtgtatgct ccttattaaa tgtatttgtt 2917741 ttgattttcc attcatcaat ctcaaataac cgctgattta tcatcatttc ctcccgaatg 2917801 taagtttcca ttatcacggc gggttttggt caaatatcta aatgcaaaag agatcatcaa 2917861 agtaacgcca cacgaatgga tcatcaatac agtaatcaaa tcaaaatgaa ccatgccgat 2917921 agcagctgcc gcaaatgccg gcagtgctga tgcgcaaatc gctatagagg ccgcttcctt 2917981 gaatgatgca atagagacca tgtttgatat ttttgtgatc cagaggccac ctgcaagaac 2918041 aaacgttaac aaaagctgga tcatagaaac caccgtatat gccagcatca tgatcatcgg 2918101 cttatactgt gccaaccaca atgtatcgat caagacctct acatcatgga cgtttggttt 2918161 ctcgagctta acgtccattt tcgcatagcc aacagaaaac cccgtttcgt tttgatcggt 2918221 gatcaccagt tgatcaggtt gaaatatgat ggcgttttca aatccagtta ctttcaatcg 2918281 cccattttca ccgcttgtct catattcatg cttcatatcg actgccatca cattctgccc 2918341 atcttcaatc ctctcagagc tcttcccgcc tgttagtttt ccgttcctga tttgaaaacc 2918401 ctgcaattga tcagcaaatt gatcattaac tccttgaatc gctgacggca tgaaagatga 2918461 aacgctgaag cgatccattt tcacaaacga aaccgctaac ggcgccatta agcaggccgt 2918521 taaaaacaga aagagaaaag agagctgcag ccagctgaag gtattcccat agcggcaaac 2918581 acctgatggg gatgcagccg ccttcaggca gcggatgata aagcttttat tctccagatt 2918641 cttcattggc attacccctt tgttccgccg gctgtcaaac cggacacaaa gttcttttgg 2918701 agaaaaaaga atagaacgca tatcggcagt gcggctagta tggcaccggc tgcaaataga 2918761 gctacttttt gctgctgcgg attagaaata aaggattgta atcctacagc gatggtcagc 2918821 ctttccggtg agcgaagcag aaatttcgtc agcaaatagt cgccaaacgg tgccataaac 2918881 gcccaaagcg cttgtaccgc gagcattggc ttaacaagcg gtagaacaat tgaagcgaaa 2918941 atcctcagat gtcccgctcc gtcaattcgc gcggcttcat caatttctct cggcacagta 2919001 tcaaaataac ctttcatcag ccacgtgttc atcggaattc cgccgccgat atagatcgct 2919061 gttaaaaacc agtattgatc gagtgcgcct attagcatcg ccaagacata aaaagcagtc 2919121 agcgccgcca ttgtcggcac catttgaatg attaaaaaga atatcaggct cttttttctg 2919181 cctgcaaacc gatagcggct gtacgagtac ccggcaagtg tcacaatcgt aacctgcaaa 2919241 accatgaccg atagcgcgat gacaagtgta ttgctgtacc aattgagata aagcgtttcg 2919301 tcaaatagcc gcttaaaatg atccaatgtc caagaacccg aaaaatcgag ctgaaaagcc 2919361 gccgaattcc ccacacggaa ggctgatgat gccgtaatca gcaacggata tataatgaca 2919421 atacttaaaa gcgtcaaaaa taaatacgta cagattttat taagcattct ggcagtgctc 2919481 gcgttcacct acataacctc ctcattgcca aaagcattcg attttttgaa agcaatcagt 2919541 gaaattccaa tgacaatgaa agaaattaac agtgtcacag ccgccgcaac ggaatattgg 2919601 ggtgatgtgc ctgttgtcag tttataaatc cacgaaatta agatatcggt cgatccggcc 2919661 ccggctcccg cactgcctgg ccctccctca ttaaataaat agatgatcga gaaattattg 2919721 aaattaaacg tatactgagt aatcatcacg ggtgctgtgg caaataaaat catcgggaat 2919781 gtaatatgcc gaaaacgctg aataaaagtg gccccgtcaa tctttgccgc ttcatacaat 2919841 tcacctggaa tcgcctgaag cactcccgtt accatgacat atatatatgg aaagccgagc 2919901 cacgtttgaa tcataatgag ggctgtcttt gtccagaaag gatcggtctt ccacgcgatc 2919961 gcaggcagct cgacaaacgg caggtgattg aataatggta tcacctgtgc attcaccgct 2920021 cctatgctgt cgttaaacat gttggaaaaa ctcatgattg taataaacgc cggaacagcc 2920081 catggaaata agaaaatcat tcgaaatatc cgcttgcctt ttataaaatc ctgattgacg 2920141 aaaagtgccg tcacaatacc taaaatgatt tgcagcgttg ttgcacagat tgtccagata 2920201 accgtccagc ccagtacatt cacaaatgtt tcacgatagg agccaaggaa aaaaatattt 2920261 aagaaatttt taaacccgac ccagtcaatc agacgattag gcggaatatg ataaaaatca 2920321 tagtttgtta atgcaacaaa cagagtcacc aaaaccggaa aaataatcac aaacaccatc 2920381 atgatatatg ccggcagtgt aaatagatac ggaaaacctt tatcgcccgc atgacagatc 2920441 atatccttgg ctgttgtatt gacttccaaa cccgccgctt tcatagcggc ggtcttacgt 2920501 gaatcatgaa tattaaagat atagaacatg aggaaaatca ttgtcacgat caattgcagc 2920561 gtgccttcaa tcagcataaa cagcgagtga tcttcaccgg gaacacttcc caatgtcatc 2920621 aatccggtta gcgcctgtat accgaaaacg cataattcaa aagcaaacaa gcctgtgatg 2920681 gcaagaaata agagcccctt tgacaactgc tgattcgcaa tctgcccaag tcctggaatg 2920741 atcgataaaa gccctgcctt tcgtttttgc tttgtaagtg tgtgatgttt attcattttt 2920801 ccgccctcta ttcttccgga cgctatcccg ccgttttatt tcacatactt ttctttaata 2920861 ttttccttta tgacgtttac agcatcattc gctgatgttt gtgtcgattt ttttcctgaa 2920921 gctgcatcaa aaattaaact ttccgctcct gtccatactt cagccatttc cggaatattt 2920981 ggagtcggcg ttgctgtttc atattgttta atcacagctg acgtcagttc attcttttgc 2921041 tcatcggctt tcttccttgc agccgtgttg gccggaactt cgtttgtatc ctcataaaaa 2921101 gcgtaagcat tggcatcatt tgcagcatac tcaagccatt tttcagccag ctcgggctct 2921161 tttgtatatt tcgaggcaac ccagcccttc ccgccagcaa aaggggcgta ttcttctcca 2921221 tttggcaatg tcggaatggg agccgctccg tagttcaatt tagcctcttt atagttggca 2921281 gctgaccaag gaccgccaat gatcgcagcc gctttgcctt ctaaaaacat ctgctgaata 2921341 aagtcgtctg cgcttgaatt gtcttgcatt cctttcggcc aatatgtctc aaaccatttc 2921401 tccgcatatt tcaccgcttc tacagcccct ttattgttca ggccgatgtc cccggaatct 2921461 gtgccgtttt ttccaaacac atatccgccg tatccagcca ataagccgta cgacatataa 2921521 aagtcagtcc attttgctaa aaatccggtt gattttcctt tttccgaagc aaacgcgaat 2921581 cgaggatctt ccgttaactt ttcaaggtct ttaaatgttt ttggcgctgt ttttaaaaga 2921641 tctttgttgt aatacaaaat aagtgtctca atgactagcg gcattccgta cactttgccg 2921701 tcaactgtca cctgctgcat ttctttatca ccaaagcttt ttgtgttaga tggcttaata 2921761 tcaagtaaat gtccttgttg tcccaaaccg ccgatccggt catatgcagc aagcataaca 2921821 tcaggcgcat tacccgccgg gccatcaaga ggaagcgctt ctaactgttc gaacatttgc 2921881 ttttcaacaa tttttactgt gacatcattt tctttttcga actttgtttt tatgctttca 2921941 atgtattctt tatacgtttc ttcgacagac acagtcagca cctttttgcc atcagagctt 2922001 gctggatttt ttgaacttga gcaggcggca aggccgattg ccaggaatga tgccgccaat 2922061 atggcgaacc ccttttttaa aagaaccatc tcttttcctc cttctattta cgaaactata 2922121 acaattgtat tgtcctatag aaagcggtta caacaacttt cgatttgtta ccgataacag 2922181 aatgttatac aggggcggca gcactcaaaa tcaaaaattc tcccggctga acggcaatga 2922241 catcgtgatg ctgtagcggc tgctctgtcc atgcatcaca gattttctta ttcctatcaa 2922301 tattcaactc tcgtaaactg acgtgttgaa ccacattccc ttgattaaag aaataaatca 2922361 gtattttttc atcaagagtc cgcgaaaagc taatgaaatc atttttgtcg tccagcagat 2922421 tccactcaag atgtccttca gtcaataaag tgttttcctg cttgcgtaaa gcaattaacc 2922481 gtttcataaa ttgcagcatg tcttggtttt gcttctcttt ttcccaaacc atacatttcc 2922541 ggcataatgg atcattttcg ccgttcagcc cgatttccgt tccgtaataa atgcatggtg 2922601 agcctgtctg ggcaaacata aaggccagca acgcgcgtgc tttcttctca tcattgcggc 2922661 atctggtcaa aaggcgcttt gtatcatggc tatccagtaa attaaacatc acctcattgg 2922721 cctgcttcat tccattcatc aaatgtgcat tgacacggtg agccatacgt gaagctgaga 2922781 tcgtctggtc agcaaagtat tcaatcatag gctctgtaaa agggtaattc atcgccgcat 2922841 gaaattcatc ccctctaagc cagggttcgg cagaatgcca gatctcacct aaaatataaa 2922901 catcaggctt ttcagtagat acagcctgcc taaatgtctt ccaaaaaacg tgatccactt 2922961 catttgcgac atccaaacgc cagccgtcaa tgtcaaattc gcgaatccag tacaaagcaa 2923021 tatcaagcaa atatttctgc acctcgggat tagccgtgtt tagcttcggc atatcagctg 2923081 taaaagcaaa tctgtcataa ttgtcgtctg tgacgggaaa agagtgaata tggaaccagt 2923141 ccttatagcg ggattgatct ccgtttttga cgacatcctg ccattgcgga gacgcgcttc 2923201 ctatatggtt aaaaaccgca tcaagcataa ttctcatccc ccgctgatgc agctggctga 2923261 ccaatgtacg aaaaagctca ggatccccga aatgcggatc aatagaaaag taatccagcg 2923321 tgtcgtattt atgattagaa ggcgcggaaa agatcggtgt cagataaatg ccgttcaccc 2923381 ctaaatcctc taaataatca agcttgtcaa caattccttg taaatcccct ccaaaaaaat 2923441 cattgacgtc cgggtccttg ctcccccacg gcaatgcatt cttcggtgac aagtcttctc 2923501 ttccatttgc aaaacgctcc ggaaaaattt gataccaaac cgttgacttg acccattcag 2923561 gcgcttgaaa tgtatcagcc tcgtgaacaa acggaaattt aaagtaataa tgaatcgttt 2923621 ccagtgtttt ttcgttataa gggcatacac ccgaacttcc gaaaaagatg tcttcatgat 2923681 cgtctgttac aacaaacgca tattgtaaac gcctaaatgg cggcaccact tcagcaaacc 2923741 aatagtcatg catttctgta gcagcaattt tcctcatcgg ctgctcgttt gccgaccatt 2923801 tgccgtcgtt gtactcatag ggatcacccc aaatgaatcg aatgtgatct gcatcacctt 2923861 ttttcgtccg aatcttgata tgcacagtcc gcccatcata agaataagca tctgtgctga 2923921 atggctggtg atgaatcgct gcatattcca tcatgtttcc ccctttgatt tccgttttat 2923981 tgaagccggc tcatagtttg aaagtatcat gatgaaattg tgggaacaat ccttttcacc 2924041 ctgttaccga taacagaata aggcgcttac agcgttgatt ctcgtacaat taactctggt 2924101 tcaaaaaata gacttccttg tgcagcgccg tcttcattca tttttttcag caacattttc 2924161 gcacaggctt cccccatttc aacaacaggc tgtctgaccg tagtcaagcg cggcgaggag 2924221 atgcgatcaa gaaacacacc gtcattcccg gtaaccgcaa cgtcttctgg aattcgcttt 2924281 ccaagggatt gcgccgcacg aatgacgccg agcgcgattc gatcagatgc gcagacaaat 2924341 gcggcctgat tgtccatgga tttcagcagt tctcttgcaa ggcattcact tttcttagaa 2924401 ctgttgtcga tccgaaacat attcgatttt ttaaagcttt tattcatcgc ccgtatatac 2924461 ccctgttctc ttgcacgttc gaaaggctca tctaaatcaa tgccaaaaaa gacaacttcc 2924521 cgctccccca gccccataac atggcgggtt gccataaaag tgcctttctc gttattcaca 2924581 tcgataaagt catagcccat ttcattttgt ccaaatacga cgagcggctt ctcaaaagct 2924641 tttattacac cttcaaaatc gttctttctc aagccggtgg caataatgcc gtcacattgg 2924701 ccaatattaa gagaatttct tgtcacaagc tggagagcat agtgattgcg atccagctcc 2924761 ctgctgattc ctgtcagcag gttcatgtaa tatggttctg tcgtatccat ttcctcaagt 2924821 atcaatagtt tcacaacctg tgttctgttt tgcacgagcg ctctcgccgc ataattaggg 2924881 atgtaattca gctctttcat cgcagaatga acaagctttt tcaattcatc cgtcaccgtc 2924941 tcagggtgat tgatcactcg tgataccgtc attttcgaaa catttgcttt tttcgccaca 2925001 tctgacaatg ttgccatttt catcccctcc ttatctgtgc ttattatcca aactagtgat 2925061 aaagtcctct attactgcta aatatacgat gcaggccaaa gagaaataaa aaagagattt 2925121 cccttaagga aacctcactt tgttaaaaac actcgatttt tcatggattc atacgctagg 2925181 tggcagactc attctctcca cttccatcag aaaatctctt ttttaaattt ctgtccactt 2925241 tttttctaaa atcggataag aataattttg catttgctca attaactcat ccggccgtga 2925301 cgagctgtga atcagtttta ggtgcgattc gttagaaaac ccttcttgaa tgctgtattt 2925361 caccattttc atcattggtt caaaatatcc gtttacattg tacagtccaa ttggcttttg 2925421 gtggatgccg atctgtgccc agcacagcac ttcaaataat tcttcatatg taccgaagcc 2925481 gcccggcatc gagataaagc cgtccgccag ctcgctcatt ttagcctttc gttcatgcat 2925541 cccgtttact tcaatcagct cagtcagatt ctgatggaca acctccccgc tgaacaaacc 2925601 gctcggcatg accccgattg cagttccgcc gttttccata atcgcgtcag caatcgtgcc 2925661 catcaagcct acgcgggagc ccccatagac aaggccgatt ccctgctcag ccatatacac 2925721 gccaagctct gccgcttttc ttttatacgc ttcatttccc ccagggtttg atcccgcaaa 2925781 tacacaaatg gttttcatct tgtcatctcc gcatctatat atcgtgttaa acattcaaaa 2925841 acacactata tattgtccca tcttcatgtg ataatatcaa tatgaaatac ataaagaatg 2925901 caggagtgat gaggttgcag ctggctgatg cagaaaaatg gatgaaagag ttttacgaaa 2925961 aaagaggctg gacagaatac ggacctttta ttcgcgtcgg ctttttaatg gaggaagccg 2926021 gagaactggc ccgggctgtc agggcgtatg aaatcggcag agaccggccg gatgagaaag 2926081 aatcgtcacg cgctgagcaa aaacaagaat tgattgaaga aatgggagat gtcatcggaa 2926141 atatcgccat tcttgctgat atgtatggtg tctctttaga agacgtcatg aaggcccacc 2926201 aagaaaaact gacaaaacga tttgagcatg cataaaaaag cggccgcgat ggccgctttt 2926261 tttaacctgt gatttcatca tggtgatcaa agaaatgctg ctttcctatt ttgtgaaaaa 2926321 ggcctgtttt atgcagtagc tccttcggct gcgattgcaa tcctacaatc atcagctttc 2926381 cattgtggcg tttaattcga ttcataatgt tcccaagcac cgcttcagct gacgtatcca 2926441 tatagtgcac cttattcatg agcagaataa gggttttcgg ttttttctgt acatgctcca 2926501 gcaatgacga ttcaagggaa tcaattgatc cgaaaaacag cggcccttct atggcataca 2926561 tgctgacaga tggatcttct ctcttcgcca gaacaggatg cgtttcctga ttgtggatgc 2926621 gggtcgcttc gctcattctt ctgataaaga acacgaatgc aagcagcaat ccggttgcca 2926681 caccgatgat taagtcaaac agaaccgtaa gggcgaaggt cgccgccaaa ataaaggaat 2926741 cagcattttt cagtctcagc atgtttgcga cttccttgcg ctcactcata ttccatgcga 2926801 ccaccatgag aatcggtgcc atactggcga gcggcacatg ggacgcataa ggcgcaaata 2926861 caagcaggac aaggagaacg actacgccgt gaacgacgcc ggaaactggg gaaaccgctc 2926921 cgttttttat attggtcgcc gttctcgcaa tcgctcctgt agccgggatt ccgccaaaca 2926981 ggggcgctgc catattcgca atcccctggc cgacaagctc cttgttgctg tcatgctttg 2927041 agcccttcat gttatcagcg accattgcgg acaaaatcga ctcaagtcct ccaagaagcg 2927101 cgatgacaag cgcagccgga aacagcataa ccattttatc caaagtaagc tcaggaaact 2927161 gaaattccgg caaatggcgg gggatttctc cataagttga cccgatcgtt gccatgcggt 2927221 cagggaaaaa gacaaccgcg accactgtgg aaataagaag cgccaacaaa gcgcccggca 2927281 ctttaggcat caccttggcg gatacaagca aaatgacgag cccgatcaca gctgtcaaaa 2927341 tggcatacac gttaaaggtg ccgagctgct gcacaatttc aaacatgttg tgatgaaagt 2927401 tctcatgttt ttcaacattt ctcaatccga gaaaattagc gatttgttcc gtaaagatca 2927461 gcacggcaat tccggctgta aaaccgacga taacgggttt gggcacgaat ttcattattt 2927521 ttccgagctt aaacagccca aacagtacca gcatcactcc tgccataaac cccgcaatca 2927581 gcagattttc caagccgtac tgcatgataa tgccgaataa aatcgggaca aaggcgcccg 2927641 tcggaccgcc aatctgatat tttgatcctc caaacaaaga aatacaaatc cctgctataa 2927701 caacagtgta tagcccatat tcaggctcga ctcccgaggc aatggcaaac gccattccta 2927761 aaggaattgc cacgacacct actacgatac ctgcaatcaa gtctttctga aatttctgca 2927821 aattgtatcc cttgaatctc cctgagaatc gcatattttg ttataacctc ccttatgagt 2927881 gattgtttat aagctcagtt tcataaccgt taatgaccac atcaagtttt cctgtttcag 2927941 ggtgaatgac aagcccgtga accggcactt ttttcggaag cagcggatgg ttcttaatca 2928001 tgttcacact gtgggaaacg ctttcttcca cgctgtgaaa accagtcagc cacgttttca 2928061 aatcgagtcc ggcactcgtc agcaaattca ggcagctatc ctccaccccg cgttcctttg 2928121 ctttctcaag aatcgaggac gcattcagcc ctgacattcc gcattcatga tggccgacaa 2928181 tgcatacctc ttcagcctgc aattcataaa tcgcgaccag tatgcttcgc atcacgcttc 2928241 caaatgggtg agaaacgatg gctcccgcgt tttttacaat tttagcatca ccgtttttaa 2928301 gccccattgc ttgcggaaga agttctgtaa gccttgtatc catacaggtg acaatgacga 2928361 gctttttcga aggaaacttt gtcgttttgt acggttcata cttcttctca ctgacaaacc 2928421 gctgattgtg ttccaaaatt gatgttaaag aaaccatttg attcatctcc catccatatg 2928481 attttgcaag ccttcttacc cagcttacag taaggaatta tagcatagga ataagccaag 2928541 aaaaggtttt caaaaaaaga cactataatt ggactgtaga atcaaaacat aaacatttat 2928601 atctttcaaa gataataaaa tttatattta atgcatccta taatccggct gcagttcgta 2928661 tatcgatgat ttgtctgaca aaaaatatgg gtgaattctg ataattaaaa aactttttta 2928721 agcagattta gctgttcgat cttcatttta agttcaaaag aaccagaaat taaaaaaacg 2928781 cagctatatt tttaacatct atttattttc gatataatga attagacaac agccataaag 2928841 ggggagcctt gttgaaacca tttgtattta tcacaaaacc gattcctgaa gagattgaag 2928901 cattcatcgg tgaacattgc cgttatgaag tatggcagga ggatacgctt ccgagtgacg 2928961 tgctatttga aaaattaaaa gaagcggagg ggcttttaac atcagggacg tccggaccgt 2929021 caatcaatcg tgagttgctg gaacacgcgc ctaagctcaa agtggtcagc aaccaatcag 2929081 taggctacga taacttcgat atagaagcaa tgaaagaaag aggagtcgtc gggactcata 2929141 caccttatac actggatgac acagttgcag atctggcttt ttcactgatt ctgtcttccg 2929201 ccagacgtgt tgccgaactg gaccgttttg tcagagcagg aaaatgggga accgtggaag 2929261 aggaagcgct tttcggaatt gatgttcatc atcaaacgtt aggcattatc ggcatgggca 2929321 gaattggaga acaagcagcg agacgcgcca aatttggttt tgatatggaa gtgctttatc 2929381 ataaccgaca tcgcaaacaa gaaacagaag acagcatcgg cgttaagtat gcagagcttg 2929441 atacattgct ggagcaatct gattttattc ttctcattac gccgctgact gatgaaacct 2929501 atcacatgat aggagaacgc gaatttaagt tgatgaagaa ttcagcaatt ttcgtcaata 2929561 tttcccgggg aaagacagtt gatgaaaaag cactgattcg cgctcttcag gaaggctgga 2929621 tcaggggagc cggcttagat gtatacgaaa aagagcctgt cacccaagat aatccgctcc 2929681 tgcagctgga taatgtcacg ctgcttcctc atatcggttc agcaacagct aaagtgcgct 2929741 tcaacatgtg caaacaggcc gccgaaaata tgctcgcagc gatccaaggg caaacaccga 2929801 aaaatcttac aagagaattt caataaatca aaaatccggt ctgataacag accggatttc 2929861 atattacata cgctgaagaa cagcacgctt ataaatatga cgggtgacga tataataaag 2929921 agcctggaat acaaaataaa tgaagatgac aattacggcc tcaagaaata aattggaatt 2929981 cagcatatta cttaacgctg catacgcaaa gcccgcgtga atcgtacctg cgataaatgg 2930041 gatgaagaat aaaaatccta tttgctttcc aaggatcgag tgaatctctt tgtccgtaac 2930101 ccctatcctc tttaacgcta acacctgcac tcccgtatct tctatttccg taaacatccg 2930161 caaatacagc atgcttcctt gcacgataaa aaacagcacg ctgacaaaca gaccaataaa 2930221 cagcattaat gcaactccct gcttcacaat ttgataacta ggagcacgtg tttgaaaatc 2930281 agatgtatgt tctttcggca ccatgttttc aagcttttca gagacatcca ccgtctcctg 2930341 ccaatgctca agctcataac ctaccattct catctgttcc ttcagcggca catcctgtga 2930401 cagactgtca aagctctttt cgctgacaac caataaacgg ctgactccat cgacagacat 2930461 caatatccct ttgttttgct gctttttcat gacataggaa agggtttttc ctgacttcat 2930521 atgaaatgct gctgtttccc cttctccaaa tgtgtctttc accatcattt gaaaagaaac 2930581 attaataaat gcttcatttt cttgtaaatg aataactggg aacccttttt cctttgcgac 2930641 ttgattatag actttttctg aaatcagcaa agcttcagct tccatcttct tatttccata 2930701 cggcaagtct gactgaaaag tgacaggaat ccctgtggca tccaccttat acgtgataac 2930761 agcatgagct tttttcaatg tattctcagc cgtctcaggc ttcatgacct gaaagcggga 2930821 agcatccttt tccacccagg aaacagactg aggaatgctt tgctcctcct gcctttgtaa 2930881 atcggaataa aacatataga tgacacctgt agctgttagt atgaccgctg taatgacaga 2930941 ggttaaaaac agcatgcgtg catgatcctt cagcctgaat atcatgttgg aacgcacaat 2931001 gatatttgtg cctttgtaga agctgtgttt ctttcggtac agcatgcgga aaaatgccac 2931061 actgctttgg gtaaaaaaga aatacgtgcc aattaacact aaaatcaaaa ttggaaaaac 2931121 ccgaaacatc atgtcaattg cattggctgt tgcagataga taataaccgc tgccaagaca 2931181 tagcaaagac aatacagtga gccatttcga ataaactggc aaacttttcg gctttttggc 2931241 tgatttaatc agttcaatga tttccagctt ccgaatccgt cccagtgata aaatgagcag 2931301 cgtctgaaac aggatgagaa agccggcaat tgtcatcaca aacgctttcg gcacaatggc 2931361 aaacgaaatc ggcaccttca cgctgagcat ccatgtcatg atcataaaaa acagttttga 2931421 aaataacagg cctgctccaa tgccggccgc aatcgccgca agagaaataa gtgactgctc 2931481 ataataaatc atcttgcgaa gctgctgctt tgatgtgcca aacagtgtca gcagcccaaa 2931541 ctctttcttt cttgcctgca aaaacgctga attggaatat gtgatgaaaa atatacaaaa 2931601 cacaatgatg acgacaagag ctgcgctcaa gcatgttttg acaaggcttc ctccatatat 2931661 attgtcttca ttgacatcag gatgaaaaat aaatgatgtg aagacaaaaa acaccgaaac 2931721 ggcaaacaca cagcttaaaa agtaggccac ataccgttgc agattcccaa gaatgttttt 2931781 acgggcgata gttctcaaat tcatgaaaat cgcctcccaa cacactcaag gtatccaata 2931841 tactttgata aaacacctgc ctgtttgttc ctctgtgaat ctctgaaaag aaacgtccgt 2931901 ctttaataaa aacaatccgt ttacagaaac ttgctgctgt ggcatcatgc gtaaccaaca 2931961 aaatcgtcgc ttccttttcc tcattcagct gagccagtgt gttcatcact tgctttgccg 2932021 attttgagtc gaggtttcct gtcggttcat cggcaagaat gagcgccgga ttgtgaataa 2932081 tcgctctggc acaagctgcc cgctgctgct gtccgcccga cacctcatat gtgcggtgat 2932141 cgagaatatg ctttatttgc agcgtatccg ccagttcatc caatcgagct tccatttctc 2932201 tcagctttac cttatccaat gcgagcggca agagaatatt ttcacgaatc gtcagcgtat 2932261 caagcagatt aaaatcctga aagacgaagc cgagttctct tctgcgaaac aaagccagct 2932321 cttggtcctt taacgttttc ggctgaatgc cgttgatcat catctcgccc tgggtcggct 2932381 tatcaatggt agccagcaaa ttcaaaagcg tggtttttcc gcttcccgac ggccccataa 2932441 tcccgacaaa ttctcctttt gacacactga gatcaaaggc gctgagcgct tggtatgata 2932501 ttgttccttt atttgaatag tatgttttcg ataggttcgt tgtttgcaac acgttcatgt 2932561 tctgctcctc ctttttcttt attataaaaa ggaagtcagc atcctcccat cgaactttct 2932621 tgcaattccg ctccccaatc ttacaatgct gtcacattca cgagggtgtc acttgaaaac 2932681 acgatggtca tcacagtgcc agccccttct tttgattccg catacagctt atggccgaga 2932741 cggctgcaca cctgttttgc taaataaagg cccattccag ttgcctcttt catggttcgt 2932801 ccgttttctc cggtaaaaaa cgcgtcaaaa atccgcggca gatcctgcgg cggtatgccg 2932861 attccttcgt cggcaaccga caagcgcgtc tcatgtccct gtgtttcaat ccggattgta 2932921 atagggtctc ccacaccttg ctttgaatat tttaaggcgt tgaaaaggat ttgctcaaca 2932981 acaaaggaaa gccacttttg atcactggaa atctgaacgg catttggcgg cacatgtaat 2933041 gttggaaaaa ggcgccgctt gataaactga cgtttttcct gattgatcag tgaacgaacc 2933101 atttctgcca aatcaaaggt ttgcggcttt acatcaaatg caaattcctc cagccgggcc 2933161 gtttgcagca tcatatcaag accgtggcga aatctctcat tctcatcctc cagctcctct 2933221 aaaaacgtcg gaaaagagga tgaggttccg ttttttcctt cctgaatcat taaggatatg 2933281 acagataccg gtgttttcat atggtggacc cattggttgg tgaaggtgta atgctgtttt 2933341 tgctgattga tatattgtga gagcctgctt tcgtattgct gcccgagtgc gttgatcatc 2933401 ttcgtccaaa gcgcttgctc tcctgttctt ggctttctgg ctttcaaaga ctgtccgatg 2933461 tcattcgaag aagaggcttg ttctgcaagc tttttaacat atgtgagaaa ggaaaattgc 2933521 cgaacataat cagcagcaaa acctgcggct aaaagagtac cgggcaaaat ccatatgtac 2933581 atcatatttt ctttggaagg ttctgcgccg ctctctacaa tgcttaaata cgcaatcagc 2933641 atggcggacc ctatccctaa taatgaaaat agaataatgg ctaagcggtc gatgagataa 2933701 gtctttaaca ttccgcttca tccttccgat tgacttgaaa ttgataacct tgtcctctga 2933761 ttgtggaaat gcaatctgtc agtcctgcat tctccagttt tctccgcagc cgattgacat 2933821 tgaccgttaa cgtattgtca tcgacaaaat caacgtcatc ccataacgcc tccaatagtt 2933881 catcacgaga gacaattttt ttatgctccc tcacaaaaat cgagagaagc tggaattctt 2933941 tttgggaaaa caaaatccgg acgctgttcc attcggcctc attctgatca ggataaatcg 2934001 tcagcccgcc aagctccact attctagatt cctgcggcaa agagggcgaa tattcaccat 2934061 atgtgcggcg caggacgctt ttgattttgg ccatcactac ctctagatgg aacggctttg 2934121 tgatataatc atcgccgcca ttttcaatcg ccattacctg attcagctca tcggtccgtg 2934181 ccgatataaa gataatcggc gcattggaaa tggtacggat ttgcctgcac caataaaacc 2934241 cgtcaaaaaa aggcaggttg atatcaagca gcacaagatc aggcttcatt tctgcaaatt 2934301 ccaattttat atcattcagc tgttcagcaa ttttcacttc atatccgtat ttttgaagat 2934361 gaccgcccag caaagaagca atccgctcat catcttccac aagcaaaatc cgatacacgt 2934421 tgatccccct tatatgtaca tcacgatgat ttttctagaa gattccaaaa ttattatagc 2934481 atgtgcggaa tagtaaatcg gtctttttct ttttgttatg atagaatgat aaaggtaaaa 2934541 ttttcataat aggcaggtgt cgtgatgaag aaaatcatgc tgtttctggc aatgacgtca 2934601 attctttcag catgtcagcc caactatacc gggaaataca tagaaattgg ggatacacta 2934661 actgactata ccaaagagtg ctttaaagag aatgaaattc cttataaata cgaaaaggga 2934721 aaactgtata tcccagaaga cgcatttgat acagcaatct acacttgttc ataagaaaaa 2934781 gcttgcagat aacctgcaag cttttcacgt tacaaaaaat gagtatttaa tttctcttca 2934841 aatcctgaag ggccgatgtc gcttttttga atgttaccgc cgttttcata aatcgtaaaa 2934901 tggcgctctg acatgaccat ccttccgctc ggcgtcagct ttgaggcaag cagggatttg 2934961 ttaaaaggag atttttcatg agagtgaatg atgtccttca tgttatctaa atcaccgaga 2935021 tcactctctt caagggtaaa ggcgtaccca atttgccagc cttctccttt gtccatcagc 2935081 agaacatagc tgcccttttc tgtctcttcc tttttgattc ggaatgaccc gactggtgac 2935141 tgtaccgttt ctccggaaag cggtatcggc tggagcgcca ggttgatgcc gaagccgata 2935201 tcaacgaggt aatcgccgtt ttccgcagac agccatacag cagcatgcgt cccttctagt 2935261 gcccatccct cttgatcgcc tgcataaacc gttcctcgaa tgagcttcac atgaaacccg 2935321 gcctcacgca agacaaaata aaggaaacca tttagatcgt agcataggcc gccgtgctga 2935381 tctttgagca gacgtcgcca tagctcttct tttgtgatct tataattctc ttttgcaagt 2935441 acggcacggt tttcgaatgg aaaacggtat gccattgctt taagaaaaag gggaagatcg 2935501 ccgaagctga catggtcttt ctcccagccg attttctgaa agcagtcttt tagaaagtca 2935561 ctcattttta tcacctaaac ttcttcttga acgtaagcag ccagcttctc cagcgcctct 2935621 tgttcatctt ctccctgggc aatcaaggta acctcagtgc ctgtgcttac cgcaaggctc 2935681 atcagcccca tgatgctttt ggcgtttact tttttcccat ccttctcaag aaacacatct 2935741 gacgtaaacc ggtttgcttc ttgtacaaac aaagcagcag gacgtgcttg cagtcctgtc 2935801 tttaatcgaa cttccacttt ctgttgaacc ataagatctc cccttttctt tacggttatt 2935861 ttaaagtgac ggtttgccct gtccgcagct gttctgcgat ttcgtcaagt tttctcagcc 2935921 tgtgattgat ccctgatttg ctgattttcc cgcttgctac catttcccct agctctttca 2935981 gcgtcacttc ctgataatca atccgcagct gcgcaatttc ccgaagtttt tcaggcagcg 2936041 cctccaggcc gattctttca tcgatgtatt taatattttc cacctgtctc agcgatgcgc 2936101 cgatcgtttt gtttaagttg gctgtttcac aattgacgag gcggttgacc gaatttctca 2936161 tgtcccgaac gattctgaca tcctcaaatc gcagaagcga attgtgagcg ccaattacgt 2936221 tcagaaactc tgtaatcttt tcagcctctt ttaaataggt aatatagcct tttttccgtt 2936281 caagcgtttt gctgtttaac tgaaactcat ttaacaggtc acataatgaa tcgttatgct 2936341 ccttataaag agagaagatt tctaaatgat acgaggaggt ttccgggtta ttgaccgaac 2936401 ctcctgccaa aaatgctcct ctcatataag aacgcttgca gcatctcttt ttgaccagct 2936461 ctttcgaaat acttcgttca aacacaaaat tctccccgag tatttttaaa tcctctaaga 2936521 tcgcttttgc attttctgaa aaacgcacaa tatagacgtt attctttttc agccgcattt 2936581 tctttctgac cagcagctcg accgacacat catattgttt tttcagcaat gtatagatgc 2936641 ggcgggcaat cgccgcgttt tcggtttgaa catcgagtac gagatggcgg tttgtaaatg 2936701 ataaagctcc attcatccga atgagtgcag acagctcggc attaatgcag cagtccttca 2936761 cttccagatt cgttaattct ttttttgttt ctgatgcaaa tgacatatag ccacctcatt 2936821 tcaaggcttc attctttcag taaatcaaca agaagagagg ccactttatg tgtatcgtga 2936881 cgtattacgt catttttata cgttacaatt tgatctctga tgacttcaag ccccatcgct 2936941 ttcagctctt cgatatcaaa atcaacagga cgcgccgatt ccatttcgta cttacgtttt 2937001 atttcgtcgg gaatgtcttc actgttcact aatatcgtat caataaaacc acagcccata 2937061 tgctgattga gcgctttcac atgatcagca gcggtgtaat ggagcgtttc gccgggctga 2937121 gtcatcacgt tgcaaatgta tacttttttc gccggcgcct ttatcacttc ttccccgatt 2937181 tttgggacga gcaaattggg aagaatgctg gtatagaggc ttcccgggcc gataataatc 2937241 aaatccgctt ccctgattac gtctattgtt tccggcagcg gatcaatctg ttcaggcgtg 2937301 agaaaaacac gcttaatgcg ctgtccgtat tctgggatcg ttgactcgcc tgagaccacg 2937361 cggccatctt ccatctcagc atgcaaaacg acactggcat tggcagccgg caaaaccttt 2937421 cctcttacat tcagcacctt gctcatttct gtgacagcgt gaaaaaaatc accggttata 2937481 tttgtcatcg ctgccaaaat caaattcccg agagaatggc ctgttaagtc attcccttta 2937541 ttgaagcggt gctgaaaaag atcttcaaca agcggctcca catcggataa agcggcaagc 2937601 acatttctga tgtctccggg aggcggaatt ttcagttcat tccgcagacg gccagagctc 2937661 cccccatcat cggcaactgt tacaatggcc gtgatgtcaa cgggtttatg ctttaggccc 2937721 cgaagcaata cagaaagacc tgtaccgccg ccaaagattg cgattttcgg cttttgtccc 2937781 atcttatttc cggcttctct tttcaatgtc ccggtgagta acatgagtat agtaatcctt 2937841 tttgaaataa tcagctaaat tctcggctaa tgtcacagag cggtgctggc cccctgtgca 2937901 gccgatcgca atgacaacct ggctttttcc ttctcttttg taagatggaa gcataaagct 2937961 cagcagatca attaatttct cattgaactt ttgcgtttca ttccacttca tgacgtaaga 2938021 ggaaacctct ttatccttgc cagtcagcgg ccgcatgctt tcgatatagt acggattcgg 2938081 caaaaatctg acatcaaaga cgagatctgc atcaattgga ataccgtatt taaaaccaaa 2938141 tgacatcaca tttacggtaa atgtctctcc ttggtttgtc gcaaagtgct tcacgatttt 2938201 ttcacgcaaa tcacgcggct tcatgtcaga cgtatcgtaa atgatttgag agcggccttt 2938261 taattcctca agcagctctc gttctagcgc gatgccttca agcggcaggc cagtcgctgc 2938321 cagcggatgc gagcgtctcg tttctttata tcttgtgacg agaatggaat ccttcgcgtc 2938381 caggaataaa attcgcggtg tgatccacgg attttcggcc atttcatcca gcgcttcaat 2938441 cagccggtca aaaaattcgc ggccgcgcaa atccatcacg agcgcaactt tgctcatttt 2938501 cgaatttgat tccttcatca gctctaaaaa cttcggaagc aatgaaggcg gaagattatc 2938561 gacgcagaaa tagccgagat cttcaaagct ttggatcgcg acagttttcc ccgctcccga 2938621 cattccagtt ataatgacaa gctgaatatc atgtgattca ctaacactca tctttctccc 2938681 ccctgacttg tctttctatt tgatgtgctg cgggtctaaa cgataactga gcagctcaaa 2938741 ttccggtgta tacgtaaatg tgccgtgcag cagcccttgt cccttcatca taaaatcaag 2938801 gatatggccg tctccagggg ccataggcag gttctgaatg tcattgacat cgtgccactg 2938861 cagtttgcct tcctctgatt ctgatacatt ttgtcctgta tatgaatcag cgacaaacgt 2938921 aaacatcatc cactcggaga caatgtggtc accgtcttta ataataaagg taaaaacgcc 2938981 ttttaattga ggatttatga tatagatacc agtctcttct ctgtactctc tgatgacgga 2939041 gtctctgact gattctccgc tctccatctt gcctcccggc gcgacccacc atccgcgtct 2939101 cggcttttga agcagaagaa ctttgtcatc cgtctgaagc acacaatttg tcactctttg 2939161 caagtacgtc acctaacctt cgtcctgtca tcgtctcttt attataccgc ttcaagatgc 2939221 ctcccacaat gaagagacat tgacaatctt ttcttctatt ttacagcata ttcattcctt 2939281 aattcagatg attttgctgt aactggaatt ctcttttatt tatggacaaa aaaaggacac 2939341 ggataactgg agaatccgtg ccaaaaaagt gtattcatta taaaaagggg gtcaattact 2939401 ttattaatca taaccgaaaa gcattacaca tgtgttacag cggaattaaa acccagtaac 2939461 gtaatgtgaa actcgtatga cagccctttt tattttaagg ttttcagcgt ttcttggagc 2939521 tcttcgacat aatgttgtac gctttgtgcc gcaatgcttc cgtctcctgt agccgttacg 2939581 atttggcgca gtgatttttc gcggatgtct ccggcagcga aaatcccttc aaccttagtt 2939641 tccatgcggt cgtttgtttc gatatagcct tcttcattcg taatgcccag gttttcaaac 2939701 ggtttagaca gaggaagcat gccgatgtaa atgaatacgc cgtctgtttt gaattcactt 2939761 tcttcaccgg ttaccgtatc gacaagcgtt acgttaccga ctttgccgtt ttcctcatga 2939821 atttccttca cagttttgtt ccataggaag tcaacttttt cattatcaaa tgctctcgct 2939881 tgaagaatac tttgagcacg gagtttatca cgtctgtgaa caatcgttac ttttgaagcg 2939941 aaacgagtca gatatacgcc ttcttcaacc gcggaatctc cgccgccaac aacgacaagt 2940001 tctttgcctt taaagaaagc gccgtcacat actgcacaat aagatacacc gcgtccgccc 2940061 aattcttttt cgccaggcac gccgattttt ttatattccg cacctgcagc aatgatgaca 2940121 gcacgggctt tatattcctt tgaaccagct ttgactactt tgtactcttt gccgtcaatg 2940181 acctctttaa tatcgccata agcgtattca gcgccgaatt ttttcgcgtg ttcaaacatt 2940241 ttgttagaaa gctcaggccc aaggatactt tcgaatccag gatagttttc tacatcttcc 2940301 gtattggcca tttgtccgcc aggaattcct ctttcaatca ttaatgtcga taaattcgct 2940361 cttgatgtgt atacagcggc cgtcatccca gcagggcccg cgccgattat aatcacgtca 2940421 taaatttttt cttctgacac actattcact ccttaaacca tcttttcaag tttgggctct 2940481 ttcttataag ataagaatcc ccatcaaacg tattccttac ccatatccta taaaatctca 2940541 tggtgatacg ctattttttt gctcaacacg attaaatgta ttcgaaaagg gtatatgtta 2940601 ataaagaaag agccttctgt ttatagaagg cccttgtcat atttattatt gaacaacacg 2940661 tcttacaaca cctttaaatg ctgctttcca gtaaggattg ctcatagagt caacagatac 2940721 gccatgagat gtattgtcgt ttaggaaagt accgtttcct aagtagattc ctacgtgtcc 2940781 atttgttttg taagtgtcaa agaacacaag gtctccgcgt ttcatttcag acgcgctgac 2940841 agcttgtcct ctgccaacta acgtatcagt tgttgttccg cctacaggtc caaggttaac 2940901 acctgcagaa gcgtatgccc agcgtacgaa tgatgagcag tcaaaaatac ggttgttgat 2940961 atcagactga gtgcgtccgc cgccaaactt gtacggagat tgtcctacaa tgcttgaacc 2941021 aacgctgatc gcgccttcaa ttccgccaga gttgctgata acagtgccgc ctgaattgct 2941081 gtttgagccg ctgctcttct tagaagatga gccgtttgac gaactgtttg atgaaccgtt 2941141 agaagaattg tctgaagaat tgtctgaaga atcatcagat gagcttgctt ttgatgattc 2941201 agttgtcgcc gtttgactgt catctgtttg tgtttcatca gatgcttttt gtgcttcttc 2941261 ctgctttttg atcaaagcag ccgctgcttc ttgttctttt ttgatgcgtg cttgttcagc 2941321 ttcagtattt gctttttgat ttgcaagttc agacgcctct gattttaatt cagaaatcgc 2941381 tttagccgtt ttcttttggc ttgcttttgc ttcgtcgaaa agcttgtctt tttcattaag 2941441 ctgtttatca aggtcttttt gcattgtttc taatttagcc aaggcagctt gaacttcttt 2941501 cagcttgtca ttcaaatccg cttcagaatc ttcgagcttc gctttatcct gctcttgctg 2941561 tttgattaaa tctttgtctg cgtccacaat agatgaaacc gcagtcgcac gagagataaa 2941621 gtcaccaaag cttgttgatc ctaaaagaac atctatgtat ccttgagatc cgccgctttc 2941681 ctgtaaagaa cgaacgcgtt ttttcaggat ttcattgcgt ttttcgatgc gtgcttcagt 2941741 ttctttaatc tcttttttca gttttttgat ttcttctttt gttttatcgt tttcttcttt 2941801 tttatcttca atcttgttgc ttgtatcaag cgccttatcg ttaatgtctt tcagttcttt 2941861 ttcaatcttt gattgatttt cctgaagctc ggttaattct ttttccttcg cttcaatgct 2941921 ggaagcaacc tcagattgct tgctttcgat tttttgtttc ttttcatcta atgtttccgc 2941981 cgatgcagtt ttacttgtaa atgggatcaa aaaactgctt gtcccgatga cggaagccaa 2942041 accaagtgta attaaactct ttctcacttt ttatatcctc ccttttactg tgaacctgtc 2942101 ctcatttgga atcgtatttt gaacatcaag tttcgttcct catactctac gaggaatgat 2942161 ggttgtttat ggttaattat tctgtgcatc tcttattctg gttgtatagc gtttatttca 2942221 catcatatgt aaaaaacact aattccttat gtacgagaat cattatacca tcaagtttcg 2942281 acaaattagc gataaatttt attacattta tgtttcaaac agatgtcaag tcacacatca 2942341 tttgtcattt ttcttaagcg tgtaaaaaaa ctgtcgatat tattttctta atataatcta 2942401 tctaacaaaa aaagagtcga ttaaataaat caactcttta aaatttacta ttctagaata 2942461 tcatcaatat atttcatata tttcgtcaaa gttgccggag agatgccgaa tcgggccgct 2942521 gtgtcttttt tcgtgtcttg cttgccatgg gcttctttcc aaatataaca gatggctgct 2942581 gcccagcctt tctcattctt caacggagca gctgcacgaa tttgctggat gacatgaaaa 2942641 acccagcagc tcatgacttc tgttttcatc tcttcttttt cagcttgctc taatagtttg 2942701 accgtttgat aagcgaaaag tgcatcctct gaaacgtcag cagccgcaga atctccattc 2942761 agaagcagct ttacaaaatg agtttcaaaa ggagcggtaa ttctctttga gcgtatcacc 2942821 gcttcaagat gctctgtttc tccctttgtg ctgctgatat aataggctgc gagtcgctgc 2942881 tccacagatg aaggaagagc ttccctccgc tcaatccaag gcgccgggcg gtcttcgccg 2942941 ggatattgcg actcgacttt tctccagatc gtctcggcaa agtcggtatg tcccgtaaaa 2943001 taagcagagc aggaaagcca gtaaaagaag gtgtcgtcac cctcaaagcc ggttttatat 2943061 aatgatttga gccatttata tccgatctcg tagcggccga caagcgccaa agtagcaccc 2943121 aatttataac gctgctccaa tagcatcgga tagacattgg agagctgatc actcaattcc 2943181 gccacttttt cgtcttctct ttcataatag tagaaaacga gaagattgca taaggcgtga 2943241 agatttcctt cattatgaga aagcacttca taagcggttt gcttcgcttt tacaacgttt 2943301 cctgaataga aataggcaag cgcgagattg ttgtatgctg accaaagctc cggatattca 2943361 gttgtgattt cctcaagcgc cgcaaccgct tcagcaagct ggccgctttc cagcaatgac 2943421 tttgcccgat cctgtttcac cagcagttca tcctgatcat acaacgaatc ctcaatgccg 2943481 tcgtctccta aatcgagcaa atcaagcaga ctatcgtttt cttcggcgaa ttcaccatcc 2943541 gggtccgcat cagaataagc ggccgcttct ttataagctt cctggaagag ccccagatgg 2943601 gcaaagttat tcgctttaaa gtaatggcac tccggcattt cggcctccag atttgccatg 2943661 atatagtcaa gaagatcgtt cgactcttga tactggccca tttccgaata aatgaccgca 2943721 agctgtgaaa gcatctctga atcctccggc tccaaatgaa ccgcgcgctg aatcagtttg 2943781 cttgcccgtt ttagattgcg ctctttatac gctttcaagc ctttatgaaa aaaatattgt 2943841 ccatcttgaa gcagctggac aatttgtgcg tgatttttat gttcagaagt gtgttttccc 2943901 acaactaccc tccgttttat acaatattac cgtcagtagt ataccataaa tcgtaagccc 2943961 ctcaatagtt caaaaggaag gattgggaaa atccctcctc ttttttattg gctgattcga 2944021 ccaaaattta cccggctttg ttttctaagt ccgcattcat tttcagctgc tgttcagcaa 2944081 aatcccggta aaggccatgg gaagccatta actcatggtg tgttccacga ccggtaattt 2944141 cccctttttc aacaaacaaa agctggtccg catctacaac ggtagatagg cggtgagcga 2944201 taacaatcgt tgtgcggccc tccatcagca cctccagcgc ctgctgaact gatttttcag 2944261 attggctgtc gagacttgag gtagcttcat cgagcataag aatgcttggg ttacggagaa 2944321 gcgctctcgc aatcgcgatt ctttgccttt gtccgcctga cagcataatg ccgcgttcgc 2944381 ccacttctgt atcaaactga ttcggcagct cctttataaa attgagcgca tatgccatct 2944441 ccgcggcttt ttcgatctca gcatccgtca catctcgttc taacccgtag caaatatttt 2944501 ctctgattgt cccggacatt aacgggcttt cctgtgatac atacccgata tgctccctcc 2944561 acgattcaag cgagtaagta tcgaccggct cgtcccccag ccgaatggtc cctgcagtcg 2944621 gagaataaaa gcgttcaagc agcttaaaca gcgtcgtttt tcccccgccg ctcggaccga 2944681 cgatcgctgt cactttccct gcttcaatga cggcgctgac ctcttttaag atcagctgat 2944741 caggcttata tccaaaagac acgcgatcaa gctggatagg cagatgtgca ttttcaattt 2944801 gttttcctgt cactgtatct tcctcttcct ctgccaaaat ctcaatcatt cgttctgttg 2944861 caccgattga tttttgcagc tgtgtgaaaa acgttgtaat ctggcccatc ggcataataa 2944921 tttgaaacaa atataaaata aaagccacga gcgctccggc tgtgagctcg cctgatgaga 2944981 cctgcatgcc gccatatccg atcactgcga caagcgctgc cattaacacg agtgaaataa 2945041 gcgggccgac aagcgattga accttggctt cacgaacgcc aagcttaaat aatgaggaaa 2945101 tccccatctt cccgcgccca tattcgacat cctccgcatt tgaagcctta acaagtctga 2945161 tttccgggag aatttgatta agcaggcctg taaaacgagc cgtttcatct tgcgtttccc 2945221 gtgaaatgga gaacattttc cgtccaatcg gcaccaaaat aagagcggcc agcggaacga 2945281 ccactaacac aagcagtgtc agcttccagt tcataataaa caagattgtc aatgatccaa 2945341 tgacagaaat gatgcctgta ataaatccgc tgatatgggt tgtaatcaat tctttgacca 2945401 ccatcgtatc gttcgttaca cggctgactg tttctccgga agcatttgta tcgaaataag 2945461 agacaggcag cttaattaat ttcttccata ataactcccg cagcccggaa atgatttttt 2945521 gtccattata gttaagcgca taggtggcat aagcgcttaa acccgcctga acgaaaaaca 2945581 ccagcgcgat caaaccgatt tgcgtgcctg acagatttga catagaaaaa ccatcgacaa 2945641 gctgcttcgt taataatgga atgagcaggc tgaccagcgt ggttactaca ctgagggcaa 2945701 gcgcaaaggc gagctttcca taagaaggat tggtccgtct tactaaggca aaaaagggtt 2945761 tcaatttact tttagatttt tgtttcttgg ttggcatata ttttcctcct gtttcagcgt 2945821 tcagaaaggt gaaaagtcat agcaaaagga tgatttttac tctttctcaa tcatatcaat 2945881 ggagaaagac tttttcagta tatttttgcc gtgatcaaaa taaaaatctc ccactcattg 2945941 tttgaatagg agatttttgt gttagacatc tttcactggc ttcttttttc tgtaagtcaa 2946001 tgttacatcc tgctgtcgca ggtcttctat tatcattttg taccgatcaa cttttgcggt 2946061 atgttcttct tttatcatct gaagggcagc ttttcgtttt tcgctattag actcaagctc 2946121 tttttttatt ttttttacaa tcaacccttt ttgccctttg atttcctctt ttaatgaaga 2946181 ctcaaatttc tttgtcaggc tgagaaagtc gttgatcggt tgattgaggg tgcccgcttt 2946241 ccccttcatt tcatcttggg taagaaacat ataggtcgtt gatacaattt ctgtttcact 2946301 ttctgaaaat aaggaagtca ctcttcatat tcctcctaag actgaaaatc aaataactga 2946361 gaaatcattt cttctttttc aaacagcttt tcaatactct cgcggatatt tttgataaaa 2946421 tctctttttt ctgttgtctg tttttttaat tcagcaacaa ttccatcatt tgcaggaagc 2946481 gcacctgtgt ggaatgattc atgaactgag attttctcca atttatcgaa tgtgtggctg 2946541 aaaccagctg caagccggaa ttgaagatcg aaggcataat gcgaagggtt ttcttccata 2946601 tgatgaatag ccgtgatgat cgcctgcttt ttgtctatga agtcttcatc gatttcctga 2946661 ctgtaaacct tctggtactt agaaatcgca tcttccatat cttcaacgat tttcataccg 2946721 ttttgataga ttctgacagc ggatgagaga ttgacttgaa tcgtttctcc cgagccactc 2946781 ttccctgtaa aataaatatc ggagccttta tagctgaagc ctttttcctt tgacaaggcg 2946841 ttgagcattt gaacgatgct gtggccgtcg acgataagtt ttagtgcgtc ttttgtttct 2946901 gtgtcgagtg ttttcaatga ggacagaatt gattttacat agtccactat ttcaccaacg 2946961 tcttttaaag cttgcataaa ttggccatgt tttagatggt ctatgaaatg ttcgtaccgt 2947021 gactctatgc ctcgcatact cgcattaata ttcgttaatt cttttttgat gactttcttt 2947081 tgcgtttcat caatataacc attttcagct aactgatcta cgaccggtcc gctgtttctc 2947141 aacaaggtat gaagaaaacc taaaaacgac ggcagttcct cttttattcg gccatacatt 2947201 tgcttaacat catcaaaatg ctcatatagg acacttactt tctttaaagc gccgtctgtg 2947261 tttttcactt tttcaatcag gtctatgtct atcccgctgg ctgcctttat aaaaccgttc 2947321 aagccgtctt tttcatagtc atccttatat ttttgaagga atttttgaat tgacctcaca 2947381 tcttcgtcag gaaccccatc cataatgttt cggatgcctt ttacacttgt atttgtatct 2947441 gccatcttca catcaccgaa tgtaataaaa tcggccttgc cgctgactcc atacagcggg 2947501 tcatcttttg agatgcgctg agtgatgttt gttgttacgc ctttgtcttc ataatatttt 2947561 tggatttctt tttttaactt ttctggcggg atggaatcta tatcttcata tttataacta 2947621 aatttcctaa taacatatct atataaactt tcatcagttt caagtaattg atcaatattg 2947681 acttgagctc catttacccc ataaacttca tcatattctc catcaatcaa ttgcaccata 2947741 acttggttat tatttgcaag tgaatgtcct aaggcgaatg tttttaaatc ctcagagtta 2947801 cctgctgctt tctttgcttt gttagtaaac tcctttgtag cctcatactg actatgatca 2947861 attcctaaaa aaagaccaaa aaagttatat gaccaatcct tattatcggc actaccttct 2947921 gaaataatct gaagctgatc aatatgtttt ttctcatcta ttatatggat tgccgttcca 2947981 tcgtaacctg attctctggt cgaactttgt atacttgtat tctgatttac aagttcattg 2948041 gaggtgtaaa tttcaatttt catattctca ggaagatcgt ggtgggtttc ctctttataa 2948101 attctgcgta tatctgcttc gaaatccttc ttagctttct taacttcact cgcaatagtt 2948161 gaggcaaact tttgtttata gtcatattct aaatcaatta accttaactt tacgttctca 2948221 ttctcaaata catttttatt tcccatctta tttctccttt ttatctatta aaaaggtgat 2948281 agaattaatt aatttctcaa ctttattttt agccttttct tcatctaagg agcatggttg 2948341 attttcattt ttgcatccaa gggtaaaggc gtattctact cctaggttat cttcctctgt 2948401 agacttaaca tatccaaaat aactgtatga ataattatat tttctatcaa tatcgtcaaa 2948461 gatgtctttt ttcttggcag tgtaaatatc cgttttcttt ttgctgcttt ttttgtattc 2948521 gcctttataa tcattttttc cactaacaat atctagcatt gtcttaggtt cattcgcaaa 2948581 actttcttct ttgtaatatg ttacatggcc atcaaacatt acattggtgt ctttatcata 2948641 actattaaat ccaatacttt ctttgttttt cccggttaac gatgatcttc ttgatagata 2948701 ctttccatcc tccggaaaca acatcctaaa ccctttcagc ttagattcca gcaaataata 2948761 tcctggttcc tcttcttttg ttgacaccat gtactctctc gttttctcgt cctgaaacgc 2948821 aggtacttga ggcagatcct tgggatcccc gctagctttt tatttttaaa aaattgtcac 2948881 agtcatgtgc caaagtcctc tttactttca attgtatagg gactgtaagc gttttaacat 2948941 agagtcaaag ggaagcatca ttctctgaac atatttctta agtgcagaaa aaggatggag 2949001 gccataatat gagtcagaaa acagacgcac ctttagaatc gtatgaagtg aacggcgcaa 2949061 caattgccgt gctgccagaa gaaatagacg gcaaaatctg ttccaaaatt attgaaaaag 2949121 attgcgtgtt ttatgtaaac atgaagccgc tgcaaattgt cgacagaagc tgccgatttt 2949181 ttggatcaag ctatgcggga agaaaagcag gaacttatga agtgacaaaa atttcacaca 2949241 agccgccgat catggtggac ccttcgaacc aaatcttttt attccctaca ctttcttcga 2949301 caagacccca atgcggctgg atttcccatg tgcatgtaaa agaattcaaa gcgactgaat 2949361 tcgacgatac ggaagtgacg ttttccaatg ggaaaacgat ggagctgccg atctcttata 2949421 attcgttcga gaaccaggta taccgaacag cgtggctcag aaccaaattc caagacagaa 2949481 tcgaccaccg cgtgccgaaa agacaggaat ttatgctgta cccgaaagaa gagcggacga 2949541 agatgattta tgattttatt ttgcgtgagc tcggggaacg gtattagaaa aataggtgta 2949601 tttggaagag aacgaaagca aggaggagca gacgtttgaa ccgatcaggc aagcatctta 2949661 tcagcagcat tatcctgtat ccccggccca gcggagaatg tatatcctca atcagcttgg 2949721 acaagcaaac acaagctaca acgtccccgc tgtacttctg ctggagggag aagtagataa 2949781 agaccggctt gaaaacgcga ttcagcaatt aatcaaccgg cacgaaatcc tccggggatc 2949841 cccgggtacc atgggcccgc ggccgcctcg agaattcatc gatacgtagc cggctagcac 2949901 ccaatataaa tctaaatacc tattactttt ttcacaaaac aaaaagagcc gtatcatccg 2949961 gctctttact cttcaatctc agaatggcgt tttttcaata cgtcaagcac atcatccagc 2950021 ggcagggatt gttctctgag caggacaagc aggtgataca gcaggtctgc cgcttcccat 2950081 ttgagttcct catgatcccg gtttttcgcg gcgatgatga cttcggatgc ttcttctccg 2950141 acttttttca aaatcttatc gacgccttca cggaagaggt acgtggtgta agctccttca 2950201 ggcatttccg cttggcgttc cgcgatcacc cgctccagtt cgttcatgat gccgaatcgg 2950261 tccgcggcct gttcttctgt ttgttccttt gtaaaacagc tgtagctgcc agtgtggcat 2950321 gccgggcctg acggttctac gagtacgagc agcgcgtctt gatcgcagtc ataccggata 2950381 cctttgacgg cttgcgtgtt ccctgaggtt tctcctttat gccataacgc ttggcgtgag 2950441 cggctgtaaa accatgtttc cttcgtttcc agcgtttttt cgtacgattc cttgttcata 2950501 tacgcaagtg tcagcacttc tttgcttgcc gcatcctgca cgatagcagg aattaatccg 2950561 tcctcgttaa aacgcagttc atctgcctgt ttcatctcac attcaccccg tactctttca 2950621 agtatgattt cacttcttta atcgatgttt ctttataatg aaaaattgag gcggccagcg 2950681 cggcgtcggc ttctcctttt gtaaaagcct caagcatatg ctgtgcgttt cccgcgcctc 2950741 ccgaagcgat aacagggacg gggacagctt cggaaacaag ctttgtcagc gtgtggtcga 2950801 aacctttttt ctcaccgtcg gagtccatgc ttgtcagcaa tatttctcct gccccgcgtt 2950861 tgacgccttc ttttgcccac gcggtgacct cccaatctgt tttctttctg ccgccgtgcg 2950921 tgtagacctt atatgtgtca gattctttgt catacttggc atcaatggca agtacgatgc 2950981 attgagaacc gaaaaactcg gctccttctg taatcagctc agggcggaga acagctgccg 2951041 tgttcaccga cactttgtcc gctccggcac gcagtatcgt tttcatatcg ctgagctgat 2951101 tgatgccgcc gccgactgta aacggaatgg caagcttcgc ggcaacctgc tccacaacgt 2951161 caaccatcgt ctttcgtcct tcgtgcgagg cggagatatc aagaaaaaca agttcatccg 2951221 caccttcccg gtcgtacact tcggcgagtt caactgggtc accggcatcc ttcaattcga 2951281 gaaattgaat tcctttgaca acgcgtcctt ctttgacatc aaggcatggg ataatccgtt 2951341 ttgtgatcat ttgcgcttca ccctttcaag cgcctcactc agcgtaaact gattggtata 2951401 cagcgctttt ccgatgatcg ctccagagac gccgtccgcc tcattgcggg cgagagcttc 2951461 gagatccgcg acggagctga ctccgccgga agcgatcacc gatttccccg tttccttagc 2951521 aagctcgacc gtgcttttaa cattggggcc tgacagcatt ccatctgtcg cgatgtcagt 2951581 aaaaataaag acttccgcac cttcattggc tagctctttg cccagttcag ttgccttaag 2951641 ggttgatgtt tcaagccatc cctctgttga aacaaaaccg tttctcgcat ccagtccgat 2951701 tgcaattttc tcgccatatt gtttcagcat ttttttgaca aacggagggt tagaaactgc 2951761 tgagcttccc aggatcaccc gctcgactcc tgctgataaa tattcataga cgtcattttc 2951821 agaacggatc ccaccgccga tttcgacttt caggttcagc ttttgcgcaa tctcaatcac 2951881 atggcggtca ttcactcttt tcccttcttt ggccccgtcg agatcaacga gatggatcca 2951941 ttcggcaccc tctttctcaa ataactcagc catgtcgtac ggtgaatcgc catatatcgt 2952001 ttccttatta taatcccctt gaacaaggcg aacacatttg ccgtttctca tatcaattgc 2952061 cggatataat gtaaaagcac tcattttttc accttctgtt ctgctgccat tttcgtaaat 2952121 tgggttaaaa tagacattcc gaccgtgctg cttttttccg gatgaaattg ggcgccgaag 2952181 acgtttcttt ttccgactac agcaggcact cgtacaccat aatcggcgct tgccagaagc 2952241 gcgttctcct ccatcccgtc aatgtaatag gaatgaacga agtaagcgta gccttgttct 2952301 gttttagtca gcagcggaga ttcattatga aaagaaagac gattccagcc catatgcgga 2952361 accttcagct tgtttccttt ttcatcttct gctttcagcc tgactgcttt tccttttaac 2952421 agcccgagtc ctgaagcggt gccgttttct tcgctttctt caaataaaag ctgcatgccg 2952481 aggcagatcc cgagaagcag ccttccctct gagaccatat cgtgaatcaa ttgatcaagc 2952541 ttcgtgtagc ccaaattgtc catcgcgtct ccaaatgaac cgactcccgg caaaatgaaa 2952601 gcatcagctt ctttcagctc ctccggcttt tcagaaacaa aatacggcac gccgacacgt 2952661 tcaagcgcct ttgagacact gtataaattc cccattccgt aatctatcac gccgatcatt 2952721 tacagcatcc ctttcgttga cggtattcct ttaactcgcg gatcgatcgt tgtcgcttca 2952781 tcaagcgcac gtcccagtgc tttaaaaacg gcttcaatca tgtggtgggt atttgttcca 2952841 taatgaacga tgacgtgcag gttcattcga gcttcgagcg ccagcttcca caaaaattca 2952901 tgtacaagct ccgtatcgaa agttccgact ttagcagccg ggaaatcagc gcgcatttct 2952961 aagtgcggcc ggttgcttaa atcaatcaca acttgagcaa gtgcctcatc catcggcaca 2953021 aacgccgatc cgtagcgttt gattcctttt ttatcgccca acgcttcgag cagcgcctgc 2953081 cctaagcaga tgccgatatc ttcagtcgtg tggtgatcat ctatatcaac atcgcctttt 2953141 gcgttaatgg aaagatcaaa ttggccgtgt ttcgtgaata aatccaacat atgtgtcata 2953201 aacggcacat ctgttttaat atccgcttgt cctccgccgt ctattgtaaa tgccagctca 2953261 atatctgttt cgtttgtttt cctgacgcgt tccgcttttc tcatttagaa atcctccgtt 2953321 ctctcgcttc aattgatctg gcatgggctt ctaacccttc cagtctggca aaagccgcga 2953381 tgctttcggc atgttcttca aaggctgatt gactgtaaga aataatgctc gatttctttt 2953441 gaaaatcagt tacgtttaat ggacttgaaa atctggctgt tccgtttgtc ggaagcacat 2953501 ggttcggtcc ggcaaaataa tcaccgacag gctcagggct gtatctgcct aagaaaattg 2953561 cacccgcatg tttgatactg ccaagcaaag cttccggaga ctgtgttatg atttctaaat 2953621 gctctggcgc gagtgtattg acagtctcaa tcgcttctac cattgtttcc gccacatata 2953681 tacaaccgta atctctcact gaagcttccg ctatttctct tcgcggcaag gtttccagct 2953741 gcttattcac ctcggctgaa accgtctcgg ccagcgccat ggaatctgtg acaaacacac 2953801 atgagctaag cttatcgtgt tccgcctgtg acagcagatc ggctgcaatt tcgctcggaa 2953861 tcgctgtttc atcagccagc acgacgattt cactcggtcc ggcaatcata tcgatatcga 2953921 catcgccgaa cacttctcgt ttggcaagcg cgacataaat gttgcccgga cccgtgattt 2953981 tatccaccgg ctcaatggtt tctgttccgt atgctaacgc cgcaatcgcc tgagcgccgc 2954041 ccattttgta aatgtctttt atgcccagct cggctgcagc aaccaaaact ccaggagaca 2954101 gcagaccgtc ttttcccgga ggcgtgacga gaacgattct ttcaacgccc gctacgagcg 2954161 ccggaatcac attcatcaaa acagatgaag gatatgcggc cgttcccccc ggcacatata 2954221 caccggcgga atccagcgcc gtcactttct gccccagcat tgtgccgtcc tttctgtgat 2954281 aaaaccagga ggattgcagc tgtctttcgt gatattccct aatattttcg attgcctgcc 2954341 taatcacctg aagaagacgt gaatccagtg aggtgtatgc ctcctcaaat tcttcttttg 2954401 tgaccagcgg gctgtctatt tcgatgcagt caaatttcgc cgtgtagctg cgaaccgcct 2954461 gatcaccgtt tgctttaaca tcttcaataa tggaccggac cgtctttctt tgctcttccg 2954521 ttccggcatc gatggaacgc ttgagagaaa gccgttccgc tccgctgatg gttttgatct 2954581 tcattttgcc gtctctcctt ccacaacgag agataggcgg gatgccattt cgtcaatcac 2954641 atcgtctttc atgcgatagc ttaccgggtt gacaataaag cgagaggtaa tgtcacaaat 2954701 gtgctccgtt tcaacaagcc cattttcttt cagcgtctgt cctgtggaaa caatgtccac 2954761 tatccgatct gcaagcccaa tgagcggagc cagttcaatt gaaccgttga gcttaataat 2954821 ctcgacttgt tctccctgct ctctgaaata actggaagcc acattcggat actttgtcgc 2954881 gattcttggc gctactccgc tccagtctgt attcggaagt ccggcgacag ctaagtggca 2954941 tttgctgatg tttaaatcca gtacctcata cacatcgcgt tcctcctcca gcatgacatc 2955001 cttgcccgca attccgacgt ctgccacgcc atgctccaca tacgtggtta cgtccatcgg 2955061 cttcgctaat ataaaccgaa gattttcctc cggcacatcg atgatcagtt ttctcgaatc 2955121 ttcaaactcc tcagggagcc tgtagcctgc ctgcctcagc agccctgccg cttcttcaaa 2955181 tatccggccc tttggcatcg ccattgtgag taacttaccc attttgctct tcctttctgg 2955241 caccgataaa ataagtgacg tttgcaaaag attttgtcat ctggtcgata ttttctattc 2955301 ccgataaatc ttgaagaacc actttgttcc ctttcatgcg ttcttcattc gcataagcga 2955361 tggcttgcgc ccgctgctct ttgctgaaaa taacagcgtc tatttcacaa ggttcgtcct 2955421 tcatatgaag ggcttcaatc agccggtcga tccgaagccc gaagcctgtt gccggtgcag 2955481 gtgaatcaaa atggcccagc agcttgttgt aacggccgcc gcttccaatg acaaaaccga 2955541 cattctcggc gtacacttca aataaaatcc ctgtgtaata gctcatgtgg ctgaccatat 2955601 tcagatccag gcggacattt tccgtacatc cgtaatcctc aagaatgtcc cacagcgcct 2955661 tcagctcatc aaccacgctt tttccttgcg cagaatcgac gatttcctcg gcacgtccgc 2955721 atacttctat accgccccgc agttcaagga gctcaagcag cctgctttta tcaatggagg 2955781 aaagcgggag agacttgaca tgctctctgt agccgacgta gttcttttca tataagaacc 2955841 tccgcagcac atcagctcgt tcaacgtttc cgagcacctc aacaaacaaa gcatccgcaa 2955901 tgccggcatg gccaattgca attttaaagg atgccagccc agcgtttttt aatgccccga 2955961 cgactaaagc aatgacctcc gcatccgcgc tcgtcgtgcc gtcaccgatt aactccactc 2956021 cgacctgctc gaactcagcc ggacgtccgc cttcacgctc ctgagccctg aatacatttg 2956081 ccgcatagcc gactcttagc ggatgaccgt gtttcagaag cttcgatgcc gccacccttg 2956141 caatcggccc cgtcatatcc gggcgaagca ccaatgtctt gccgtcctga tcaagtagct 2956201 taaacagctg ctgctcttca attgctgact ggacgccaac ggtatcgtaa aactccagtg 2956261 tcggcgtttc cataaattga tatccccatt tatcaatcaa atcggttaac gatcgtctca 2956321 cctttttttt cgtttcgtat aaaccgggca gtgtatctct catgccgtgc ggtttttcaa 2956381 acataaacat caacccgagc acctccgctg ttatcttatg aaggaaaatt ccgaatcctt 2956441 tagttcgcta atatgataat atgttagcag atgaaagaat gaaaatcaac gcttaacttc 2956501 agtaaggata tttttagttc aaatatcctt ctcctcatta tgaaaaaatc atgaataatg 2956561 tattaaaggt acgtaatatc tcaaattctt tatgtttggc atgctataat acaaatcaaa 2956621 tagagaacaa ggagataaag atgaaaacac tgcgaactct atgtgtcctg atgattcttt 2956681 caggcgttat ttttttcgga cttaaaatag atgcaaaaga tatagatatt ccttttttga 2956741 acagccttaa aaaagtggtt tctgatagcg atacagactc agctgcgaat agcaaaaagg 2956801 agctgaaggg aagcgcaaaa ccgctggatg tcatccttta caatcaaatg gacgcacccc 2956861 ggctctataa cggctgtgaa gtaacaagcc ttgcgatggt gctgaattat gcgggatacg 2956921 acgtgacaaa aaataccctg gcaaatcagg ttgccacagt gcctttgaca tacagcagcg 2956981 gattaaaggg tgatccgaat gacggatttg tcggggatat ggcgaatggc cctggtctcg 2957041 gtgtctacca tcgaccgatc tatcagctgg cgaaaaccta tgcgggagac aaagtgtctg 2957101 atctgactgg aaaaagtatt tccgctgttt atcagcagct tgaaaaaggc aatccagttt 2957161 gggttattac gacagccaac tttacgccag ttgacaacat gcagacatgg aaaacgccaa 2957221 acggaacgat agaaattacg tacagcgaac acagcgtcgc cgttacggga tatgatgata 2957281 aatatgtgta tctcaatgat ccgtatggct ataaaaacag aaaaaccgat agaacaagct 2957341 ttgaaaaagc gtggaaacaa atgggcagcc aggccgtggt tattcaaaag taaacacctg 2957401 aagcctcact atgctctatt ctgagcaaat acgacaatat tcatgctttt tgtatcaatc 2957461 ggtaagatcg attcattttc catttttcac ccaaaattgt ctttactttc aggctgtctg 2957521 tttttatgat taaagcagat tcagccttgc cccgatctat gcgagagaag ccggtgcaag 2957581 tcgctgacgc ttctcttgca aaaaatgaaa gatatccggg gaggatttat cattgaaaaa 2957641 aatcgtgtct atcctattta tgttcggttt ggttatgggt ttcagccagt ttcagccatc 2957701 aaccgttttt gcagctgaca aagtggtgca cgaaacaatt atcgtaccaa aaaatacaac 2957761 atatgacggg aaaggacagc ggtttgtggc agggaaagaa ttaggtgacg gaagccagtc 2957821 agaaaaccaa gaccctgttt ttcgtgtgga ggatggagca accctgaaaa atgtggtgct 2957881 tggtgcacct gcagctgatg gcgtgcacac ttatggaaac gttaacattc agaatgtgaa 2957941 atgggaagat gttggtgagg atgcgttaac ggtgaagaag gaaggaaaag tgacgatcga 2958001 cggcggttct gctcaaaaag cgtcagataa gatattccaa atcaataaag ccagtacctt 2958061 cacagtgaaa aatttcacgg cggataatgg cgggaagttc attagacagc ttggtggttc 2958121 aaccttccac gttgatgtga tcatcgacaa gtgcaccatc acaaacatga aggaagcgat 2958181 attccggacg gacagcaaaa caagcacggt cagaatgaca aatacacgct actctaatgt 2958241 cggtcaaaaa tggattggtg ttcagcatat ttacgaaaac aacaacactc aattttaaca 2958301 aaaaaagtcc gctgatgtta ttcagcggac tttttcaatc tttcttgcat ttcttccttc 2958361 gtatagatga tcctcatcgg atttccgccg acaaatgccc cgtcaggcac atccttatgg 2958421 acaagcgttc cggcggacac aactgcgcca tctcctattt tcaccccggg cagaatggtc 2958481 gtgttggcac caatcatcac ttcgtccccg atcagaactt tgccgatccg gtattcgtga 2958541 atcaaatact catgggccag aatggtcgta ttgtacccga tgattgtatt tgttccgact 2958601 gagatctttt ccggaaacat gatatctggc atcaccatga gggcaaagga tgtctgtttt 2958661 ccaaccttca tccgcagaaa tgtgcggtac agccagtttt tcatccctat aaacggcgta 2958721 tatctcgcaa tttgaatgac aatgaaattt ttgacgacct ttaaaaaagg taccgtttga 2958781 tagacatgcc acagtgagtt ggcccccgag accggatgac gatctgtttt tctcacagat 2958841 tacttcactc caacgatttg taatagatca ctcattttct caagcataaa atccggctca 2958901 tgcttcgcca gcatttccgg ccctttaatc gtccatgcga ctcctgccgt ttttgtaccg 2958961 gcgtttttcc ctgccagcac atcatggtaa ttatcaccga ccataatggc ttccgccggc 2959021 tcgcttccta gctgtttcag cgctaacagc acaggctcgg gatcaggctt tgcattcgtc 2959081 acatcatcaa gggtgacaac tgtttcaaag aattcgccga ttcccgtgag cttgaggccc 2959141 atattgacag tatctcttaa ttttgttgtc acaattccta atgtaaagcc ggcttttttt 2959201 aatgcatcca gggtctcata taccgtttca tattcagtga cgagtgaatc atgcatgtca 2959261 tgattgtacg ctctgtacat agcgatcata tcctcgcatt tatcagggtc catcgaagag 2959321 aacgtatcaa aaagagacgg cccgataaat gcaaggacat cttctcgttt atacttgctc 2959381 ggataataat gctccagtgt atgcaaaaag gacgcgataa ttaattcatt cgtattaata 2959441 agcgttccgt ctaaatcaaa cagaatcgtc gttacttgtt tgtcactcat attgcttcct 2959501 ttccaaccgc tgagggtttc cattttttcc acgtgtgcgc aatagccatt gtcagcagaa 2959561 ctgctgtggt gacacgaatc aaaagaagcg gccagaccgg tatgccaagc ggaataaaga 2959621 caagtgtatc ttccacgacc gcgtggcagg caacgagaaa tataaatgcc aatgtcatgt 2959681 cccgcttgct cacgccgtca tcctcgacag ctttgatcat gacacccgct ccgtaggcca 2959741 gaccaatcgt cagtcccgtc accatcgtca tagacgtatt tttattcatg ccaagcagct 2959801 gcgtaaacgg cgacagccac ctggaaaacc gataaagcca gcctaaatct cttaaaaact 2959861 ggatgataat catcagcggg atcactattg ccgccagctg caaaacacca agtccggctt 2959921 tcgttaatgc ttctgccaac attcctagcc agctgtctgg cgccgcgctc ttcgcagcga 2959981 taaaaccgta ctgcgccgtt tcctttccgc catgccaaat gaggttgatg acgatggctg 2960041 acacagcggc caaaccgatg cgcacggcca atatgacgcc aattctgata ccaacctttg 2960101 cggcaactgt cgattcgata atcaagttat gacagaaaga aagcataaca gctaaaataa 2960161 agacttcttt cacagataaa tccaatgtta aaatcccggc aattcccgca tacagattca 2960221 gcatatttcc cagtacaagc ggaatggccg cttcaccaga aagcccgaag agacccatta 2960281 ccggtgtgat cagccgtaca agccaatcca tgacaggggt atgctggagc aaagtgacca 2960341 atagcgttac cgggaaaatc actttaccca gcgtccatgt tgtttgaaaa cctgctgcaa 2960401 gaccggccag aaagatcttc ttcatccctc atcccccttt gttgacgtct actccgcgta 2960461 ccgctccttc gagtatccct tgacgcgtct gaagatgatg gctgccacag ccaaaacaat 2960521 caatacgatt gaaatcacct gagcgatgcg aagtgaatca gtcagcatta agctgtcagt 2960581 ccgcattcct tcaataaagt atcttccgat tgaataccaa atgatataga tcaagaacat 2960641 ctcgcctcta cgcaaattcg ctctgcgcag cagcagtaaa acaatgacgc cgacaaagct 2960701 ccatagtgat tcatataaaa aagtaggatg ataatattgc ccattgatat acatttgatt 2960761 gatgataaat tcaggcaggt gcaggttttc taaaaaggct ctgctgacag cctcgccgtg 2960821 cgcttcctga ttcatgaagt tcccccagcg gccgatcgcc tggccgagca aaatgctggg 2960881 cgcggcaata tccgcaagct tccagaacga aaggtttttc actctcgaaa acacataacc 2960941 cgttaaaatg gcgccgatta atccgccatg aatggcaatg ccgcccttcc aaatcttaat 2961001 gatttctccc ggatgtgccg cataatagtc ccattcaaag gcaacataat aaattcgtgc 2961061 gcaaataatc gcaattggaa tggcaaacag gacaagatca ataaacgtat ctttctgcag 2961121 cccccgtttt tcactttccc tcatcgctat ccacagcccg agcaaagcgc cgagaccgat 2961181 aatgattccg taccagtgga cggctaacgg ccccagctga aatgctatcg gattgagtgg 2961241 ttctatcgct tcattcattt aacgccaact cctattcttc ttgttcaccg tcttcaatga 2961301 cgtccgccag cttgttggta aattgttcag cggcattcag ccccatccgc ttcaatctga 2961361 agttcattgc tgccacttcg atgatgactg caagatttcg gcctgggcgg acgggaatcg 2961421 tcagttttgt aatttctgta tcaatgattt tcatggtctc ttcctcaagt ccgagccggt 2961481 cgtattgctt gccctgctcc cagagttcaa gattcatgac aatcgtgatt cgtttattgc 2961541 ttctgaccgc gccagcgcca aatagcgtca tcacattgat aatgccaagg cccctgatct 2961601 caagaaggtg ctcaattaat tccggagcgt ttcccacaag agtatcctga tcctcctgcc 2961661 gtatttcaac gcaatcatcg gcaacaaggc gatgccctct tttcacaagc tctagcgctg 2961721 tttcgctttt tccgacgccg ctttttcctg tgatcagcac gccgacacca tatatatcga 2961781 caagaacgcc atgaattgct gtggtaggcg ccagcctgct ctcaaggaag ttggttaaac 2961841 ggcttgacag tcttgtcgtt ttcagcggcg atctgaggac aggcacccca tttttctcgg 2961901 aggcgtcaat cagctcctgc gggatgggca tatctctaga aagaataata gctggtgtta 2961961 catcagtgca cagagaatcc attcgctgct ttttctcctc ttcaggaagc tgttcaaaga 2962021 aagaaagctc tgtttttccg agaagctgca cgcgctccct cgggtaatat gtaaaatatc 2962081 cggcaatttc aatacctggt cttgataggt cactcattgt aatcgggcgg ttaattcctt 2962141 cttctccgct gattaattcc aaattgaact gttccattac gtcttttgtg cgaacctttg 2962201 ccacgatatg ttcctcctgt tccgggctgc cccgagcttg ctcacaatac tttcatttta 2962261 tcactttcgg gcttgaacct aaaacagatt ttataaaagg ggggaaaaca cctcagctgg 2962321 tctagatcac tagtctgaaa aagagtaaaa taaaggtatt caaattccag aaaggcggat 2962381 catctatggc agagagtctt cttatcaaag acattgcgat cgtgacagaa aatgaagtaa 2962441 tcaaaaacgg ctatgtcgga atcaatgacg gaaaaatcag cacagtttca acagaacggc 2962501 ccaaggagcc atattcaaaa gagattcaag cacctgcgga ttccgttttg cttcccggca 2962561 tgattgacat tcatatccac ggcggctatg gcgcagatac aatggatgct agcttttcca 2962621 cgctcgacat catgtcgtca agactgcccg aagaaggcac gacgagcttt ttagccacaa 2962681 cgattaccca agagcatggg aacatttctc aagctttggt gaacgcaaga gagtggaaag 2962741 cggctgaaga gtcctcttta ttaggtgcag aactgctcgg cattcattta gagggcccct 2962801 ttgtttcgcc taaaagagcc ggagcgcagc caaaggagtg gattaggcct tcggatgttg 2962861 agcttttcaa aaagtggcag caggaggcgg gcggactgat caaaattgtt acacttgcgc 2962921 cggaggagga tcagcatttt gaactgatcc gccatttgaa agacgaatcg attatcgcat 2962981 ccatggggca cacggatgcc gattccgcat tgctgtcgga tgccgcaaaa gcaggggcga 2963041 gccatatgac tcatctgtac aacgcgatga gcccgtttca tcaccgagag cccggagtga 2963101 tcggaacggc gctggcccat gatgggtttg tgacagagct tatcgccgat ggcattcact 2963161 cccatccttt agctgcaaag cttgcttttt tggcgaaagg cagcagcaag ctcattttaa 2963221 ttaccgattc catgagggca aaaggactga aagacggcgt atatgagttc ggcggccaaa 2963281 gtgtgacggt aagaggacga acagcacttc tttcagacgg aacccttgcc ggttcgatcc 2963341 tcaaaatgaa cgaaggcgca cggcatatgc gtgagtttac aaattgctct tggacggata 2963401 tagctaatat aacttctgaa aacgcggcca aacagctggg catctttgac cgaaaaggca 2963461 gtgtgactgt gggaaaagat gcagatttgg tgattgtcag cagtgattgc gaggtgattc 2963521 tcaccatttg ccgcggaaac attgcattta tatccaagga ggctgaccag atatgaaagt 2963581 aatggaatgt caaacgtatg aagagctaag ccaaatagca gccagaataa cggcagatac 2963641 aatcaaagaa aaacctgatg ctgttctcgg tttagcgacg ggcggcacac cggaaggcac 2963701 gtatcgccag ctgatccgcc tgcaccaaac tgagaatctc tcatttcaaa acatcactac 2963761 agttaatttg gatgagtacg ccggactttc aagcgatgac ccgaacagct atcacttcta 2963821 tatgaacgac cgtttttttc agcatatcga cagcaagcct agccggcatt ttattccgaa 2963881 tggaaatgca gacgatttgg aggccgaatg cagacggtat gaacagctag tcgattccct 2963941 cggcgacact gacattcagc ttctcggcat cggccgaaac ggacacatcg gctttaacga 2964001 accgggaacg tctttcaagt cgcgaactca tgttgtgaca ttaaatgagc aaacccgcca 2964061 agcgaatgcc agatattttc cctccataga cagcgtgccg aaaaaagcac tgacaatggg 2964121 aattcaaacg atactctcaa gcaagcgcat tctgctgctt atttctggaa aaagcaaagc 2964181 ggaagctgtt cgtaagctgt tagaaggaaa cataagcgaa gattttcccg catctgcttt 2964241 gcacctgcat tccgatgtta cggttttgat tgatcgtgaa gccgcgtcat taagaccttg 2964301 aaaggaacat gctgacttat gaatatcaat aaacaatcgc ctattccgat ttactatcag 2964361 attatggagc aattaaaaac ccaaattaag aacggagagc tgcagccgga tatgcctctt 2964421 ccttctgagc gcgaatatgc cgaacaattc gggatcagcc ggatgacagt tcgccaggcg 2964481 ctttctaatt tagttaatga aggcttgctc tatcgcctga aagggcgggg cacctttgtc 2964541 agcaagccaa aaatggaaca agcacttcaa gggctgacaa gctttaccga ggatatgaaa 2964601 agccgcggga tgacaccggg cagcaggctc attgattatc agcttattga ttcaactgag 2964661 gagctcgcgg ctatattagg ctgcgggcac ccctcctcta tccataaaat cactcgggtg 2964721 cggctggcaa atgatattcc gatggcgatt gagtcctcac atattccgtt tgagcttgcg 2964781 ggtgaattga acgaatcgca ttttcagtcg tcgatctatg atcatattga aaggtacaac 2964841 agcataccga tttcccgtgc aaaacaggag cttgagccaa gcgctgccac cacggaagaa 2964901 gcgaatattc ttggtattca aaagggagcg cctgtcctat taattaaacg aacaacatat 2964961 ctgcagaacg gaactgcttt tgagcatgca aaatccgtat acagaggcga ccgttataca 2965021 tttgtccact atatggatcg tctttcataa aaaaagcctc caaccctttt taaggattgg 2965081 agacatggcg aaaatcaaac tggtctggtg ccggacgata tgtttctttt ttcgtcttga 2965141 acttccagat cggtgatttc gttttgccgt taaaactgtc ttccactata atgtaccaat 2965201 aataaacaga ctgcggttca agatgatccc agcggaattc agctgtgtcc ccgctcttca 2965261 cttgctcccg ttttccgagc tcttcattgg tatatacgtt acattcaaaa taatcggttt 2965321 ccaccttttt gattcttggc ttcaaatcaa gcgaaaggga aaattcatcc ttgttgccat 2965381 aggtatccgt atcatagtag ttcttatcct ttacatacgg agagtacgtc gatacgtgca 2965441 ccatgtcatt ggcttggtca aattgaagca aacgcaaata cccttggccg ccttctggcc 2965501 cgccctgata atcggccagc atttgatgca caagacgatc cggtttccca tcaccatcat 2965561 catccagctc atctgttttt ctcatcgcac tatgataatg cccgctcaac accatcacga 2965621 cattcgggtt cggctttacg atttctttga atattttctc tccgattggg cttctgtttc 2965681 cgctgaccag caaatactca tgaaaagcta aaatggccat ccggtcagga tgcttcttca 2965741 gcacctgatt catccacgcg atgtcttcat ccgtaatgcc ccatcccatg tacagcatga 2965801 tataatcatt gccgttgcta gaaatcaggt cataatgtcc gcggttattt ttataggaac 2965861 cgccataatg aaatttttta tcaaaacgat cgctgccaaa atatttgcca aacgccctgt 2965921 aggagccgtc cttatgtccg acatcgtgat tgccggccag cacgccgtaa ggaattccgc 2965981 tcttatccag aacggacatt gaccgatcag cgtttttcca ctgtctgata tcggcggaat 2966041 catctacaat atcacccgtg tggaacacat atttgatatt gagctgcttt tgattatctt 2966101 ttatccattc ggtctgttta tcaaaaatat gcggatagct ttcggcgtaa tactgtgtat 2966161 cagacatcca gacaaatgtg tacatatcct tcgcaggagg aatttcatcc tgtacaatca 2966221 cattcatttt cgactcccgt acaaaatcgg cggcaatcac agacgctttc agcgtaaacg 2966281 gtttgtcatc cttcgcgacg aagctgtcaa caggctgcca ttcgtttgtc cgataattcc 2966341 aagcatacat cgtcaccttt ctccccggca aagaactgcc cttccagact gattctgcca 2966401 gatcattctc atcaattgat ggatcaaccg tcacttcaaa gcgatgataa gggaaaagct 2966461 ctttgttttc tgtcgatact gtttttccat cagcagctga tacccgctcc aattctttat 2966521 tcgtaaatgg ggtctccctt tccggcacaa agcttttcgg cggttcagtc agtgacgcgt 2966581 gcttaaatat tttcacatga ttgcgcgctg tatattgaaa tcccctataa aaaccaacat 2966641 ccatggcatc attcgtcgga tctttcaccc gtacagaaag cttggcctta tgcgtgtcgg 2966701 cttcgctgtc tataacctcc ggctggtccg gatgctctcg ttcggtttta aatatcctct 2966761 caatcactgt tttattgccc gcgagatccg ttgctgtcac ttttagagaa tgttttcccg 2966821 gcaaaaggtc agaagatgac gtatgatatg ggagtgtaat gctttctcca tctaacgacg 2966881 cctccgcttc ctcaattctg ctccatttat catacatatc cgcctgcagg ataaggtttc 2966941 ctttatacgt ttgcccctcg gtgatattcg gctcaatgtg aggtcctgaa ttatctaccc 2967001 gtacaaccag gctgacattt tccttcccgt cgcttgcttg aatatggtga gcgccttcag 2967061 aaagctttga tgtatcccac tccagcagct gtgatgtaaa tagtccgtca ggcagattga 2967121 actgaaattg ccagctttta ttcgagcgct gattatcgcc aataaagagt tccttctcag 2967181 gagacaccct ctgatctctg atcaccgttc catccgataa caccaatcgg gcgtttttga 2967241 ctaagaagtc atcacggttt tcagccgtat caaacggaga caccttcgaa cctgaacgta 2967301 tcgtaatacg ctgcagctgc ttccctttcc gaagcagtgt ctctggcaat ggaacagaat 2967361 aggtgcggta tttatttgtt gtatcatcga acaccttcag cactttgcct tccatcgtta 2967421 ccgcgttttt aaaataaagg ttcgttttcc tcgtatcgaa tgcaaaatat acttcttttt 2967481 ccatcgcggg ctctgtcact tgttttttcc cgtcaatcca tagcttaatg ctgtcagctc 2967541 gcccttctgt cgtggctttg agaaattgag ttcccgacag cgtgtctctg ttttcaatat 2967601 tcatccgcag accgtgcgcc ttgcttgttt gtttaatatc aatcattttg accggcgttc 2967661 tcgcttcatt gatcccgtcc ccggccgcca cataatactc tagctgatcc ttcccgatca 2967721 attcaggcga atacacaata taatggaaga gattatcgtt gcggtctttt tcagcaagaa 2967781 ttcgcttaaa cggtttgttc tcatccgtcc ggtagtaaaa ggccactgtt ttcactaggc 2967841 ttcggtcccg tatgtcagcc cgcagctcaa tgctttcagc agggcggaca ggcttgcggt 2967901 cagtcaaatc ctcaatgacc ggcttttctt tatcgagctt gattttccgt ttctggtcgg 2967961 gcacctgtgc ctgtaatacg gttccgggag acggattctt ttccccgatt gaaatgttca 2968021 gaagttctgc tgttccgttc agtggatact tataaagcac tgatgacagc cggcgcagcg 2968081 catgtttccg ataatgcgca accgaaatgt cctttcctgt attcgttgat atcacaacgg 2968141 cccgcggcct cgtattggcc ataccctctg tctcgtctat caccgcaaga ttttttcctt 2968201 cttttagttg tgtctgataa taacgattga aatccgctga cgtcaattct ggatgcccgg 2968261 caggcttcag ccagacgaca aacgtttcgc cggatggtat caagatcctt tcatcaggtc 2968321 tccaaatcag atcggagtca ggcccttctt ttgggtagcg gtaacggata tggtagtctt 2968381 taaaatcaat cgttctgtca gtcgtattaa aaatctcaat aaattcataa ccgtctgcgc 2968441 gtcctatatt cttcgtatca accgccagct ctgtgatcag aagctccgga atatgggcaa 2968501 ggtcagcctg gtatccttca agcttcagtt tcttcgtctc cgactcaacc cgctgcttcc 2968561 cattcgacat cacaatgtaa tactcaagct cgctgttcca aatcaaacgt ttcggaattt 2968621 gtgccaaaaa cttgcggacc gctccggggg tcgggtccat cggcaccatt ttgtagccca 2968681 gctcattact ttgtttataa aaaagaaagg cggaaaatgc ttgatacgaa ttatcgcgaa 2968741 cttgagcctc aatcattaga ttgcttctca tttcagcttt cacatcaatt tgaggaggat 2968801 tttcaagcaa gggtatgtaa tgaggcgttt gaaatagttc ctgctgtaca acaggaaaag 2968861 ctttcgattc atgatggccg ccagacaaaa cggaaagaaa agacagtaat atagaagcaa 2968921 taaccgtgta tttcctcatc aaagcacctc ccttttcatg tattttgcgt ctgaacaggg 2968981 aagcttatga gttcattttt gtgcataaag aacaaaaaaa cgtctgtctc ttgaaaattc 2969041 cactattacc cagtaaacta aggatagtta accagttaac aattaaatca gagaggcaaa 2969101 ttgatggaca acagcattca tgatgaatta tttcaagcta tacaacaatt cgcattaaaa 2969161 agggataaac gcgtctggca aaaggtgcag ataccatcca ttggcatatc ctcacaacat 2969221 cacgatcacc tcaaaaaaga ctggactttg acccagcttc acattgtttc ctgcatacat 2969281 accagccaaa atgtgaacaa cagcttctta gcatcccgtt tacacatctc aaaagccgct 2969341 gtttcaaaag cggttcatgc tttgttgaaa cacaatatca ttacagtgac aaaaaagcct 2969401 ggcaacaaaa aagaaatttt ttatacgcta actgatagcg gcagaaaatt ggcggcatta 2969461 catgaacagc ttcatgagaa agcaaaggag caatataaac agcttttcaa tgaattttca 2969521 attgatgatt taaaaacagt gactgcgttt ttcaacttgt ggatcaaata tatgtaaaaa 2969581 gagtctcacc cgcatgggag agacctttgg aattctatta tgccccgtca aacgcaacga 2969641 gaagtgaaac aggtccgcgt gtatacagac cggactcagc ataacaaaaa tcttcctcta 2969701 atctgatatt ccgcatctta tccagcacaa tattagctac aatttcgatt tcgtttttgg 2969761 caaaagctgc tcctacacag ttatgaatgc cggatccgaa agcgagatgc cgggcggcgc 2969821 cgctaaaagc gctcttgata ccaagatctt cccgatgaat attaaacacg tcaggctgtt 2969881 caaatgcttc agggtcccgg ttagccgcac cgatcataca aaaaacaatc gtatcttttt 2969941 tgatttccat accgccgacc actgtatctt gggacagctg ccgcggaatc agctgaaccg 2970001 gcggtttata acgcaatgtc tccgcaatgg ctctcggaac taacgaacgg tcagccaaaa 2970061 catcattcat ctgctcagga ttgttgagca aatggtagat catcagtgcc agcgtcttat 2970121 cagccggttc cgttgcggct aacagcacat taagaatcag tgcgagtata tccttgtccg 2970181 acagcgccat gccttcatat tcagaagtac ataggatcga aattaaatct gatcccggat 2970241 tgacgcgacg ttctttaatg accggcatca agtattggga aagctgttcg ctgcaccata 2970301 acgaatgtgc ccgcgcttca ggagattgag agatactcgt gataaaatcg gcaactccgc 2970361 tgtgccactc agagattttt tcatggtctc ttttatccag cccgagcatg tccatcgtga 2970421 cgcacaccgc aaacgtcttt ccaaaatcat tgacgagatc acttttccct ctttcaagat 2970481 aaggcgctaa caagttttct gcattttgtt taatcaatgg agacagatga tccagtgcgt 2970541 caccgataaa gcttctcact acaattcttc ttttggcaga gtgttctttt ccatgcattt 2970601 gggccagcac agggcctcgc atgactggtt cggcacgctc aacaagtgat ttcgtcgtga 2970661 agatatccgg atgctgaagg atatagcgga catcatgata gcggctgata aaataactgt 2970721 ctatcgactc ttcataatga accggatctt cctcccgcag ttgtgaaaaa taagcatatg 2970781 gattgttttg aaattgatca gaaagcacac taaacaattt aatcgattgg ctcatgtttt 2970841 actcccccta tcatccttca gatgtgatcc gtttctcaga aagcatctgc gccatttcct 2970901 gtacaatgag atacccttga ttcggccgca tacaaataga aaattcatgg ttactgatct 2970961 tctcacccag cttccacgga cgatgataag caaggagtgt ctcttccacc tctaaaatat 2971021 ccggagctcc gataaaaaac ggcagctcag ctatgacata ttccacagcc aaattcagca 2971081 tatcctcact gacttcttcc atcatcaaac tgacgccccg cgcacgcccg attatcgctt 2971141 cacgagacat gtccaaacaa gcatgtcgaa aatgaggctg ctcaaaaaat gcatgttcaa 2971201 cttcttgtct caacagctgg taggctttgt tatctataaa atcagaaaat gtatgaatcg 2971261 ccttcggatc cccgccatga gccacaaggg ctctttctgc aaatctcctg tttcgtgata 2971321 cctctttcct tacttttcgt tcagcctttc ctctcggagt tccaagcgct tctagaagat 2971381 tagccgcctc atgccctgca agtaaaactg aaacgctttt aaattgagct ttcgcccatc 2971441 caattaatct gtaaatataa tcctctgaaa acctgctgtt aaatgggctg atccccacca 2971501 aaacatgcct gcgccgttca aatatttctc tgcagttttc tgttaatgcc tcagcaataa 2971561 aatgcacaga ccttctttcc gttaccattc cggtcatctc attcacccct aaaacttatc 2971621 ccgctttaag tcatcaccct caaatacaag atggaatagc tagaacaact gaacaagacg 2971681 aatggcaggc atcacttaaa gtttccaaat gttttttaag attttaataa tcattttcaa 2971741 tacccatatc atgataaatg tttactagta aacattagtc attttatccc ttttccttcc 2971801 aaacgtcaat atgatctgtg cccaaatatt tgaaaataaa tgtaaacatc acattttcca 2971861 cacacttttt acacgcatat tcagcatgac atatcaacaa atagtctaaa caccaacaat 2971921 tgacaacgaa aacaagaaaa gataaaataa aattgttcac cagtaaacga tttgttttat 2971981 tgtttcatcg taaactatta ttcctaagaa agaaggtagc ctatgtctga tttgacaaaa 2972041 cagatgatat acgacatata cgtgagactg ctgcacctta atgaacaaaa agcgaacact 2972101 tcacttcagc aattttttaa ggaggccgca gaagaggatg tagctgaaat tcccaaaaat 2972161 atgacaagca ttcacgtcat tgactgcatc ggccagcatg aacccattaa taatgccgga 2972221 attgccagaa aaatgaactt atcgaaagcg aatgtaacga aaatcagcac aaaactgatc 2972281 aaggaagaat tcattaacag ctatcagctg acagataaca aaaaagaagt ttattttaaa 2972341 ttaacccgta aaggcagacg gattttcgac ttacatgaga aactgcataa aaaaaaggag 2972401 ctggcttttt accaattcct cgattcattt tcacaagaag aacaaaaggc tgtattgaag 2972461 tttctagagc agttgacgtc aacacttgaa gcagaacaaa ccgatgggac tccagacaaa 2972521 cctgtaaagt aaacaaaaag gcggtgtaca ctttggctca tacaaaatca aaggcagtat 2972581 tgatcttata cactgtttgc ttcagtgcat tttttgcatc tttaagccag aacatttatt 2972641 cacctattct tccgatcatt aaagaatcat tccatgtttc cacagctatg gtgaacctgt 2972701 cagtctcagt ttttatgatt gtgacagcaa taatgcaaat tatattagga gcgatcattg 2972761 attttaaagg cgctcggatc gtcttgatta ccggtattct ggcaacggca gcagccagca 2972821 tcggctgtgc ggtgactact gactttacct tgtttctgat attcagaatg atacaggcag 2972881 ccggttccgc agcactgcct cttattgctg ccacaacgat cggacagctg tttacaggaa 2972941 atgaacgcgg gagtgcaatg ggaacgtatc aaatgctcct gtctgtcgca ccggctattg 2973001 ctccagttct aggaggattc ataggcggag cagccggata cgaagggatt ttttggatac 2973061 ttgcggccat ctctatcgtt ttgctggtga caaacagcat cacctttcct aaagattctc 2973121 caactgaatc tatgcagcaa gccaaaggca atgtgttcgc tcattataaa tcaatattta 2973181 caaatcgaac agggaacgtc attttgactt taagttttgt tctctttttc atttattttg 2973241 cagtaattgt ctacctccca atattgctga cagagcatta ccatatagat gtgggtatag 2973301 caggactgtt atatttgccg ctggcgctga gcacgattgc aggtacgttt ctgtttaaaa 2973361 gaatacaggc aaaaatcggg ctgcacacct tgtttatcgg aagcaatgtg attgccgcct 2973421 gcagcatcat tttatttgct gttacacatt ccgtttctct cgttctcatg gctctgacgc 2973481 tggcactgtt tggcatctcg atgggggtta ttcctccctt gtactctaca atgattacta 2973541 atgaatttga gcacaacaga gggagtgcaa tcggaatgtt taactttatc cgatatacag 2973601 gcatggcagc aggtccgatg gtatctgcct acttgctcac aatgatgccg tctgccatgt 2973661 cctttagcct cctaggcctt ggatttgccg cattgagctt ttgccttctt ccgccaatgt 2973721 tttcgccgca gaagcgcacg aaacaaaaaa agcaccacat gtaaaaaagc tgcctttgcg 2973781 ggcagctttt tttatttttt tctaagcggc tctaaaatgc ctttttgaat cagcaaatgg 2973841 aagaccgaca ggataacgga tgcccatatc gctgtgccga agccgtcgat ttgaaagctg 2973901 tcacccataa tggacgcggt catcataagc gtgatggcgt taatcacaaa caagaagagt 2973961 ccaagcgtca ccatggtgac cggcagtgta aatataatta aaagcggttt aatcagcacg 2974021 tttaagatcg ataaaatgag gctggcgata atcgctgccc caatgctgct gatatggatg 2974081 gagtcaatat atccatcaat gacgattaat aacaatgcat tgactaaaat gctgactgcc 2974141 cattttacca tgtcatttca tatccctttc tgacgggacg ataaaaatcc aaatgatata 2974201 aatgagcaaa accggcaaga cacttgtcat aatggctaag atgacagtta tgactctgag 2974261 gagtgatgcg tcccaattga aatattccgc gagacctccg ataacaccgg cgattttctt 2974321 atttttttct gagcgataaa gcttattcat tcgatcacct ctgtgagtac tttagtttga 2974381 tggcgcctgt tagtgattct gagaagacgg tgatgttttg atcatgtgcc tgatttgaag 2974441 tgaacatcat ttctttttga atcgtatcat ttttttcctt cagcatctct acatccatta 2974501 attcatggga cagcgtacca agattgcttt tcagctctgc cttcactgcg agatcgtccg 2974561 gaattgcaag ctctacattt ccagtcgttg tttttgcata aatggagcgg cagtctgatt 2974621 ctgttacgtt aatcgcaata tttccgttaa agctttgaac gtcaatggat tcgcttttcc 2974681 ctcggagatc gatcaatccg ttaatggttt ccgcttctat cgtaccgcag ctgtggcttg 2974741 cgagcttaat ttgcccgttg gccgtttcag ctatggcttt ttcggctgtt aaatacgaga 2974801 acgacagcac gccgtttgtc gttttcgctg agaactcttt tacatgtaaa tgttcccctc 2974861 tgactggacc gttaaacagc ttcacccgaa tcttatcata ctccttctga ggaatataca 2974921 aagtgacatt cgttttcatc gtctttttct cagtacggat aaaaaactta ttacctttga 2974981 tttcacattc aatatgctga agaaatgcgt gtctcgccgc atcctggctg tcagcgcgat 2975041 ataccttcgc ctggcattcc gctctgatat cgtcatcttc ccaagggacg atatttacgc 2975101 tgccattggc aatttgcagc tcaacactgg aaaagtcagt atctttaaat tgaaaaatgt 2975161 gctgaacatc atacgcatgg ccaaagttta aatcaaggtc aacttccttg acctttttca 2975221 cagcagaatc aatccagtca aacagcttgg ctcctaaaga cggtttgccg ctttcttttt 2975281 ttgccgttgt aaatggctct tcctcgtcat gaacgtgaac tgagagcgct gtgattttct 2975341 cttctttttc cttgtagtcg ctgtcaagct tttcaatcag tgtcaaagct tcttgtgctg 2975401 taagctttcc ttcctcaaca agcttaagga ttcgttcctt ttcttgcttc attacgatct 2975461 cctccccatt gtctacttat gctgcacgca ggaccttaat gccctgaatc acattccaaa 2975521 tgataatgcc aatgacaact aagaaataaa taaccgctcc cccgatgatt acaaatacag 2975581 gaagcaagct gtctccatca atcgcaacgg ctccgccaag taaagcaata aaaaggaaca 2975641 gccagccgac aaacggaaca atgtgagaaa taagagagcg tatcgcatgg cgttttgttt 2975701 ctttctcatt tacaacaaaa tatgcgacaa tcggcacaat gattggcgca atgaacacac 2975761 tgaaataaca aagtgatgca ataatagctt gattacggtt caattcattc cacactccta 2975821 ttgtgaattg tccatgacaa aagatcaggg acgttttact tatttatacg tttaaaatct 2975881 cttcaggttt caaattcatt ctttagacat gctccgattt acggaaattg gattttaaaa 2975941 agttttagaa gtagaatctt ccggctatac cgattacaat atgtaaaaag cttacggcaa 2976001 ccaaggaggc tggacaagca atggagaaag atcccagtga ctatacagta acacaagaat 2976061 cagtgttaaa gctgattcag gaacaaaaaa gaatgaatcg tgaaatgatc accgagcttg 2976121 agcagattca cggacccttc ccgatctctc acgatatcca atatataaaa gtgctgctcg 2976181 acagcagcaa cacacatatt gttcaagatt taatgagtgt aagtaagcag ctgtataaga 2976241 agactttgta attgcggaaa acatatcatt cattataact gaaacaaagc taaaggttag 2976301 atgacaatat cttgcctttt ttgttttgaa aaaacaagtg attccctggc tgtcacaaaa 2976361 tgattgtaac aaaaaaagcc tgccggcaca tccagttaat ggactctgtc ggcaagctgt 2976421 aactatcaga aagagatagc cgttcaaaat taacgtaaca attgaagcac gttttgcggc 2976481 tgttggtttg cttgagcaag catcgcttga gaagcttgag aaggaatgtt gttctttgtg 2976541 aactcgctca tttctttcgc catgtcaacg tcacggatac gggactcagc agctgtcagg 2976601 ttttcagaag aagcaccaag gttgttgatt gtgtgctcta gacggttttg taccgcacca 2976661 agtttagcac gttggtttga gacattgttg attgcagtat caatactttc aagttgtgta 2976721 tcaaaaggag tattagcaaa atctgttaca ttaagtgcgt ttactcctaa agcagttgat 2976781 gacatgctgt caatgttaac tgtaagctgc tggccagcat ttgctccaat ttggaaagtg 2976841 aaaccatcag tttcagtacc atctaataac tttttgccgt tgaattcagt acgatttgaa 2976901 atgccatcaa cttcctcaat aagcgcatcc atttcatctt taattgcacc aagatcttct 2976961 gcttgttgtg tacctgtgtt tcctgcttga acagtaagtt cacttctaaa cctattatgc 2977021 cgtaaagaaa aagcttgcct gctaagccca aggatggact tgccgacaag ctgtcccctc 2977081 ttaacagagg gttttaagat gtagctgttt cttttgcttt caagagcgat ttcatgcgtg 2977141 ttttgtcacg ttcgataaca ggctttaaat aacggcctgt atacgattct tcaacttcag 2977201 tgatttcctc aggcgttcca gacgcgacaa tggttccgcc tccggctccg ccttccgggc 2977261 ccaaatccac aatgtaatcg gccgtcttaa tgatatcaag attgtgctca ataaccagta 2977321 cagtgtctcc gttgtctacc aaccgttgca gcacgacaag aagcctggcg atatcgtcga 2977381 catgcaaacc tgtcgtcggc tcatctaaaa tgtagagcgt acgtccggtt gagcgtttgt 2977441 gcagctctga cgcgagcttc acgcgctgcg cttctccgcc tgacaaggtc gtcgccggct 2977501 ggccgagcgt aatataacct aaaccaacat cataaagggt ttggagcttg cgtttgattt 2977561 tcgggatatt ttcaaagaaa gaaagagcat cttcaaccgt catatcaagc acatcagaga 2977621 tgctttttcc tttgtacgtc acttcaagcg tttcacggtt atagcgtttg ccgtgacaca 2977681 cctcgcatgg aacgtatacg tcaggaagga agtgcatttc aattttaata atcccgtctc 2977741 cgcggcaggc ttcacatcgt ccgcccttca cgttgaagct gaaacggcct tttttatagc 2977801 cgcggacctt cgcttcattt gtctgcgcga atacatcacg aatgtcatca aatacaccgg 2977861 tgtatgtcgc agggttggat ctcggcgttc ttccgattgg cgcctggtca atgtcaatga 2977921 ctttatctaa atgatccaaa cctttaatct ctttatggct gccgggcttc gctttcgctt 2977981 tatgaagctt ttgcgccagc gccttatgca aaatttcatt aacgagtgta ctctttcctg 2978041 aaccggaaac acctgtaact gctgtaaacg tcccaagcgg gaacttggca ttcacttttt 2978101 tcaggttgtt ttctgatgca cctttaattt caatgtaacg tccgtccggc tttcttcttt 2978161 caggaggcaa tgggataaac tttttccctg ataaatagct gcccgttaat gaatttggat 2978221 cttccatcac ttcttccggc gtacccgcag atatcacctg tccgccgtga atgccggctc 2978281 ccggtccaat atctattaaa taatctgctg ccatcatcgt gtcctcatca tgttcgacaa 2978341 caatcagcgt gttcccgagg tctctcatat ttttcagagc gctgatcaag cggtcgttat 2978401 cacgctgatg cagaccgata gacggctcat ctaaaatata aagcacaccg gataaacgcg 2978461 agccaatttg agtcgccagc ctgatgcgct gcgcctctcc tccggacaat gtacccgctg 2978521 ccctgctcaa tgtcaggtaa tcgaggccga ctttgtccag aaagcttaag cgctccacaa 2978581 tttcgcgcaa aatcaaattg gcgatctgca tatccttctc agaaagggta agatctttaa 2978641 agaaggcaag tgcgtcggcg acagacagct cggtaatttt cccaatgtgg cggccgtcaa 2978701 tcagtacggc aagcgcctct ttctttaacc gatagccttt gcacgtcgga caagacttct 2978761 gagacatata ctgctccatt tgctcacgta tgaaatcgga gcctgtctcc ttatagcgtc 2978821 tttcaatgtt gcgcaatacg ccttcaaatt gaatttcacc ttcgcggatt tgtccaaaat 2978881 cattttcata tcggaaataa atcaggtcat ccccgctgcc gtacagcact ttatccagtt 2978941 gatgcttcgg caaatctttg accggcacat ccatatcaat cccgtagtgg gtgcagactg 2979001 cctcaagcag ctgaggataa tattgtgagc tgatcggtgt ccaaggggcg accgcattct 2979061 ccttcaatga caaatcttga ttggggatga caagatcggc atccacttca agcttcattc 2979121 cgagaccgtc acacgtcgga cacgccccga acggactgtt aaacgaaaac agacgcggct 2979181 caagctcacc aattgaaaat ccgcagtgcg gacaggcatg atgctcgctg aacatcagct 2979241 cttcctcacc gatgacatcg atcataaccc gtccttcacc taaacgaagc gccgtttcca 2979301 atgaatctga cagccgggct gccacgcctt ctttcacgac aatccggtca atgactacct 2979361 caatggaatg cttcttgttc ttttctaatt cgatatcgtc ggaaagctca gccatctcgc 2979421 cgtcaattct gactctgaca tagccttgtt tcctaatctg ttcaagcact ttgacatgag 2979481 cgccttttcg gcccgagaca atcggcgcca gcacctgaag cttcgtccgt tccgggtatt 2979541 ccagaattct gtccaccatt tgctcgatgg tctgggatgt aatctcaatt ccgtgttccg 2979601 gacaatgagg cttccctact ctcgcatata aaagacgcag ataatcataa atctcagtta 2979661 ccgtaccgac agtagacctc ggattgcggc tcgttgtttt ctgatcaatg ctgatggcgg 2979721 gagagagccc ctcaattgca tccacatccg gcttatccat ttgccctaaa aactggcggg 2979781 cataggcaga cagcgactcg acataccgtc tctgtccttc agcatatatc gtgtcaaagg 2979841 caagggagga tttacctgat ccggacaaac ccgtgacaac gacaagctga tctctcggaa 2979901 tcgttacatc tatatttttc aggttatgcg ccctggctcc cttcacctct atccgatcca 2979961 tagccatttg ttcatcatcc ttccgctttt agctctaaaa gtaaatcgcg aagctccgcg 2980021 gctctctcaa agtcaagcgc cttggcggct tccttcattt catgctccat ctgttcaacg 2980081 actttctggc gttctttctt cgtcattttc gacagcttcg gcgcggcttt tgttttgtat 2980141 tccgctttat cctcagctgc tactgtggca cgaatgacat cgcgaatttc tttatttatc 2980201 gttttcggcg taatgccgtg ctcttcgtta aaccgctcct gctgctcgcg gcggcgtttt 2980261 gtttcattaa tcgcaatttc catagacttc gttattttat cggcgtacat aatgacgcgg 2980321 ccttccgcat ttctcgctgc ccgtccgatg gtctggatca gcgaccgctc cgaacgaagg 2980381 aaaccttcct tatccgcatc caaaatcgca acaagggata cttcgggaat gtccaaacct 2980441 tccctcagca ggttgatgcc gacaagcaca tcgtacttgc caaggcgcag gtcgcggata 2980501 atttcaatcc gttcaagcgt cttgatctca gaatgcagat agtttacttt aatgccgatt 2980561 tcctttaaat aatcggtcag atcctctgac atcttcttcg tcaaagttgt cacaagcacc 2980621 cgttcattcc gctcgattct tgcttgaatt tcgccgatca agtcgtcaat ctgaccttcg 2980681 attggacgga cgtcaataag cgggtcaaga agccccgtcg gacgaatgat ctgttcgacc 2980741 atttcatctg tatgttcaat ctcgtacggc cctggtgttg ctgatacata cacgatattg 2980801 tgcatatgct tttcaaattc ctcaaaacga agcggacggt tatcaagcgc tgatggaagc 2980861 cggaagccgt gatccacgag cacctgtttc cgcgcctggt ctccgttaaa catgccgcgc 2980921 acctgaggaa ttgtcacatg cgactcatcc accacgatca taaaatcgtc tgggaaataa 2980981 tcaagaagcg tatacggcgt tgaacctgga ggccgcagag tcaaatgtct tgaatagttc 2981041 tcgatgccgg agcagaaacc catttcacgc atcatttcaa gatcatatct tgtccgctgc 2981101 tctaaacgct gcgcttcaag gagctttccg ttttcatgca tgaccttcag ctgctcctca 2981161 agctccttct cgatattttg aatcgccttc tccattttct cggcccgcgt tacgaagtgg 2981221 gatgccggga aaatcgcaac atgatctcgg tcgccgagaa tttctcctgt cagcgcatct 2981281 acttcccgaa tccgttcgat ttcgtcaccg aaaaattcaa ctctgacaca atgctcatca 2981341 cgggatgccg gaaagatttc cactacatcc ccgcgcacac gaaatgtacc gcgctgaaag 2981401 tcgatatcgt tgcgggcata ttggatgtct acaagttttc tgagcagctc gttgcgctca 2981461 atttccattt cagtccgcag tgacacgacc atttcccggt attcctcagg cgaaccgagg 2981521 ccgtatatac aagacacact cgcaataata atgacatctc tgcgctcaaa caaagctgat 2981581 gtggcggagt gtctcagttt atcaatttca tcattaatac tagcgtcttt ctctataaat 2981641 gtatccgttt gaggcacata cgcctccggc tgataataat catagtagct gacaaaatac 2981701 tcgacagcat tgttcggaaa aaattccttg aactcactgt aaagctgtcc agcaagggtt 2981761 ttgttatggg caatcacgag agtcggctta ttgacttctt taatcaaatt ggacaccgta 2981821 aatgttttcc cagttcctgt tgcacccagc agagtctgat gcttcttgcc ctcctgaatt 2981881 cctttcacaa gcttttcaat ggctttcggc tgatctccct ggggctgata tttcgagact 2981941 aactcaaagc gatctttcac aaaaataagc ctccgtttct ttaacgaaat cttcctatag 2982001 atatagtaac acaatggaaa gcaaaatcac taaaaatacg aactaaagtt cggtggtttt 2982061 ttatttccag ctgtttttgt gtataaaaaa cctgctttta aaacgtaaaa gcaggtattc 2982121 agtctttata ttcattatgt ccgatttatt cttctttttt ctctgcagct tttttggcca 2982181 tatacagtcc gccagccaca agagacacaa catccaatcc tacaataaaa tacgtttctg 2982241 tatagccttt taaataagag gcaaacagca atgcagctgt taaagcgatc gccacataat 2982301 gattaaaggt gactctagta aatagaacaa caagcataaa agggaaaaac aatgcaaaaa 2982361 cggcttttgt aatcaacaaa aaccctcctc agggattctt catctgatct gattatagta 2982421 aaaaatgaag aatcggacaa tcgtgcattc gctccctcta cttacaccat accccttttc 2982481 agccaaaatc aatcaccata tttgcatttt ggtgccggtc aaaacttatt ccatggtgcc 2982541 gctgttctaa tcagcggcac tttttttatt acatcatcaa gtccgccgcc agattccgag 2982601 aataaaagaa aataggcata cagtaccagt acggccgcat ttttcaggat aatataacca 2982661 acttaactat tcattttatt taggactttc tgcgtttgac agcattttcc tgaaaaccta 2982721 caattaaatg atagtgttta ctatcatttt ttaaacacag gctccgcaat aaaaagacta 2982781 gagagaaaaa caaaatgaat gaagaaaaga ggggtttcaa atatgtattc tgttttattt 2982841 cgccaggcag aagagtccag ccagctggct ggagcaaaag gaatgaattt gattaaattg 2982901 accaaacacg gtcttcctgt tccggacggg tttattattc aaacgaatgc gctcgcacgt 2982961 tttatggagg acaaccagct tcaagagact agtgaaaacg tcgaaggcgg gatcatttcc 2983021 ggaacatttt cggatgagct gaaagatgag ctgactagtt ccttttataa gcttagagaa 2983081 tcatatcgat ccgtagccgt gcgttcttcg tctgcttcgg aagatttaga aggcgcctca 2983141 ttcgcgggtc aatatgaaac ctacttaaat atcaaaacag aggaagagtt tctggctaaa 2983201 gtgaaagaat gctgggcctc atttttttct gggcgggtca gcagctataa gaaaaaaatg 2983261 aacaatcaaa tcgcagagcc gttaatggga atagtcgttc aggggctgat cgattcagaa 2983321 atgtcaggtg ttatcttcag ccgcaaccct gttacccatg atgatagaga gcttttaatc 2983381 agcgccagct acgggttggg tgaagctgtt gtttcaggaa atgttacccc agacacgttc 2983441 attgttaata aatcttcgtt tgagattcag aaagaaatag gtgcaaagga aatctacatg 2983501 gagtctgcgg cagaaggaat tgctgaaaaa gaaacgagtg aagacatgcg cagccgtttt 2983561 tgccttacag atgaacaagt gattgaattg gctgaaatca caaaaaaaac cgaagacctg 2983621 tacggatatc ctgttgatat agaatttgga attgctgatc atcaaatata ccttctgcaa 2983681 gctcgcccga ttacaaccat tgatcaggac aaaaaagcgg cagaagaaaa acgcagcttc 2983741 atgattaccg acactgatat gaatgatttc tggcttaaca tggagtctaa tattgaaggt 2983801 ccggtgagtc cgttattttc atccttcatc gtgccggcat tggaatatgg cttgaagaag 2983861 agcatgcaaa agtttccgat tggtgtagtt gttgatgaag taaaacttta tcgcggacat 2983921 atttattcca aaaaccaagg cggacagcag cctccttctg aagactgcgg caaagagctt 2983981 ttcccgattt tatcggagca tatgtatgac atcatcaatc acacatacct ccctttttac 2984041 cggacactgg accagctcgc acaaactgag cataccgcag aaagcgcact ggaagctttt 2984101 caaaaactaa aggcctttta tctcacggct tatgaagagc actttaatat cgttttcccg 2984161 caaatccttt taacaaacaa actgcaagcg atgtatcagg acattcaagg agagtccgaa 2984221 aacgctcatt tttacgagat gctgacagga aaaatgaaca aatcactgga aacggaccgt 2984281 tgcttatggc tattttctgt ggaagttcag gagaacccga accttctggc catttttgaa 2984341 aacaacaagc ctgaacagct ccaggagaaa ttggaacaaa cagatgaggg aagacacttc 2984401 ctgaagaacg tccatgaatt cttgcaagaa tacggatgga gatctgttaa aagtcatgat 2984461 ctgattgaac aaatctgggt ggaaaatccg tatttcgctc tggccaatat tcaaaattat 2984521 gtccgtaatg gctatcattt tgacaatgaa tttcagaaaa caaaagaaaa acgagagaaa 2984581 ttatacaatg aattcttgga aagcatagaa gatcccggtt tacgcaccga atttgaccgc 2984641 tattatcaat ggacactgaa ctctgcaaat ataaaagatg atcaccactt ttatattgac 2984701 gccatgctgg atgccaaggc gagaatcttt ctgctgaaga taggtgaatt gctggcggaa 2984761 aacggtgtca ttcaagatcg ggaggacctt tggttcttat atgacgacga agtggaacaa 2984821 gcgcttcttc accctgtatc cctgcaagaa aaggctgaaa aacgcagaca gatttttcat 2984881 gagtatgagc tggcccaagc cccggcctac ctcggcaccc cgacaaaaga acagctcaaa 2984941 gcagctgaag aaattgtcgg cgctgtgata gaggatgaaa aaaacacaga gaatcatatt 2985001 tttggcattg cggcatcaag cggcattgcg acaggtccgg tgaaaatcat tcgggacgcc 2985061 aatgaatttt ctcaattcgc gcctggagac gtactcgttt gcaagatgac cacaccgcta 2985121 tggaccagcc tgtttcaaga cgccaaagcg attattacag acacaggcgg cattttgtct 2985181 cacgctgcga ttattgcccg tgaatacggc attccagccg ttctcggcac acgcacggca 2985241 accgaaagac tgcgagacgg tgacatcatc actgttgacg gaagcagcgg caaaatcaca 2985301 gttgtcagcc ggtcctgatg cgtccccctc tttcttatac aagcggggcg ggtgtatact 2985361 tgtcctgcca gtatattcgt gaggtgaaac gtattgagac cgacaaacaa gagaatcctt 2985421 gatgctgcca tgcagctgct cgtcaaaaaa ggatatcgcg caacgactac aaaagaaatt 2985481 gcagaaaaag caaatgtaag tgaagcgacg attttcagga actttaaaaa caaacaagga 2985541 ctagttgagg ctttgctttc tcagcattct tcaaacagag gcagcatttt ggaacaaaca 2985601 gaaggggatt tgtacaaaga cctgcttcat atcggaacct gtctcttgga ggagctcgaa 2985661 catagaaaag atatcattaa aatcagcttt cgtgaaccgg ccatgtttca ggatgtcatt 2985721 aaccacgtca ctgaatatcc ccaatctatg aaacagctat tggttgatta tctcaaaacg 2985781 atgggtgaga aaggggttat tcagacagga aatgaagcgg aacatgccga cgtgttcatg 2985841 tcgattatct tcggttattt cattcaccgt ctccacttag gagaccgggt catatcaatg 2985901 ccccaggaaa aaatgctgga gcatagcaca gctctatttg tcaaaggaat ttctgctgat 2985961 taactccttg gcataataaa aaggaggatc ccaatgagct caagaaaaga atgggcgctg 2986021 atcgtctcgc tattattggg ggccattctg gttcccatta actcaacgat gatcgcggtc 2986081 gcgctctcat ctatttccca tacgtataac gagtccatcg caagcatcac ttgggtggtt 2986141 accgtttatt taatcgtgat ggcagtcaca cagccgattg caggaaagct cggtgacatg 2986201 tacggcaata aaacaatgta cttatgggga gtcggccttt ttctaatcgc atctctaggc 2986261 tgcgcccttt caccgagtct gctcctgtta attgtctttc gggcattgca ggctgtcggc 2986321 ggggcattgc ttacgccaaa cagcattgcc attatccggc atgttgtttc tgaaaaacgc 2986381 ctaccgaaag tgtttggatt tttcggactg ggcgcgggac ttggtgcagc actcgggcct 2986441 tttatcggct ctatactgat tgacagcttc agctggcatt cgattttttg ggtcaacatc 2986501 ccgttcctcg ccattgcttt atttacggca ttaacgatgt ttcctcaata taaagaaaat 2986561 aaatctgacg cgccgctgga tatcatcggc tctctcttgc ttgcaggcag catcgtttcc 2986621 attatcctgc tgacgaaaaa tgaggctcca tggggatata ctgtatacag tgtattgata 2986681 cttctttttg ttccgctttt tttcagaaga gaaaaacgta cccagcaccc catcattgac 2986741 tttgcactgt ttaaaagctc aacctttaca aatgcgaatc tatcagtctt gttaagcaat 2986801 ttgatgatgt atgccgtctt attgattatg ccgttattta tgacgaacca atttgggctt 2986861 aatacatcta acagcgggat ggcgctttct gtattttcga tcttcatgtc agccagcaac 2986921 tgggtgggcg cgcagctcca tcacaaatgg ggagccaaaa aaatcatttt tctttcattt 2986981 gccatgatgg ctggtgcgaa tctattattt ttgctgttaa gcagctcgca ttctgtcttg 2987041 ttcctcatgc tctctcttat ccttggcggg ctcgcttccg gagtcggtct gaccagcatg 2987101 caggtttcat cccttgccac agtagacccc ggtatgtcag gagtggcatc tgggattttc 2987161 tcgaccttcc gttatttcgg aagcatcatt tcatcagcct taattggcct gatttcggga 2987221 tatcacaccc tatttatgat tctctttgct gtatccatca tcggcgtttt tgtttcattg 2987281 ggcatcaaat ctgatgaaac ggcacggata gaaaaaaact cagcgtaaca caaaacagcc 2987341 cggcatcgca tcatcctgcg gtgccgggct gccttttatg atcccgaagc gactgcttcg 2987401 tcttcacggt catcctttac gaagaggatg cccaattcat gatgttctcc ttcataagaa 2987461 gctcgctggt caaaacgaat ttctccattc aaaccgataa tttcaagctt tacatatgca 2987521 cggttatgct gaagcgcttc atagaaatca gaaacgttct taaccggtat gccattgact 2987581 ttcgttatga tttccccgat tttcaattcc agatcctcag ccggcgtatt ggggataatc 2987641 ccaagcacca ttaagccctg atcccttttc gagaaataaa acggagccgc gttatcattc 2987701 actctttgct ttatggacag aaaaatacgc cctaacaaag cggtacagac cgctgcaccc 2987761 gcaagcggcg tccacagtaa gctcgctgca ccgagaactg cgacggcaag accgagaata 2987821 caaacgcgtt tcgctgtgat ccttatactc gtttcaggca gcgatccctg taccctttgt 2987881 ccaaatccga caaagtaagg aatccataga aaatggaatg agccgccggg aaccgtaaac 2987941 acgggccacc agctaaggtg cgattctaaa ccattaccgg gcacgagaag gaacagcggc 2988001 aaaagccaaa cccggtttgc cagctgctgt ccgatcggca aaccgcggct gcttacgaca 2988061 agtgccggtg atgttctcac atgcgcagaa cgataagcaa ccgctccttc agtgataatc 2988121 agcaaaccta gaaacacagc cacagccggc caaacaactg caaatccttg cggaaatctc 2988181 tccagaaagg gctccgcctg atatatttgc agtccaaaac ctatcagcat actcacactg 2988241 acgatatatg cagcagacat ccagtttgcg cgaagagtga acgctgccgc tgcagtgata 2988301 acggcaataa tcgcaagtaa accgagagga atcgatattc cgagtccacc taaaataact 2988361 gacaaaagaa gacctggaat cagtcccttt gtatatgtaa atttcagatc atcataaata 2988421 tctgctattc ttgtatgaaa ggtttttcgt tcccgtttga ttcttacata gccgaaagcc 2988481 aaggttatga tgataaaaaa ccagaaaagc gggtgtaaga agaacaagcc cgcgcttttt 2988541 aacagttcaa ttccccattg aacagacact atctctcacc gcctcaagcc aaacatgtta 2988601 ctcatattct atcaaatatt aaatggcttg gatatcctca ggagagttta tctctcttgc 2988661 gtcatccaca gcgtgacatt cgatagtgaa aaatccttta aatagtggtt tacatccaca 2988721 tccaataacc cgctgattag atgcatcgac ctttttatat ctgtcagatt aattcctaat 2988781 cgcttatggt ttttcattaa gtagttaaaa taatgtttgg cgcattcctc attaatgtca 2988841 tttactgatt cgacattggt gtaattgacc aaatatctgc tgaacagcat aagaagactt 2988901 agtgcttttg tagctgaaaa tgttacgtct tgtgttctgt cttttaattg ttccactaat 2988961 tcataatatt tttttttcac gcacaatact tgccctcttc aattgtgaac ccccattttc 2989021 tttatacaga taagcacggg ccagtataag cagcagtact ggagtgctaa caagcattct 2989081 cgctaacgtt actctttaaa tacctgtcgt tcagctgcca ttaacctgat tactgttctt 2989141 tttagaacct tcttatattg tatgaagtaa acaaagacta ggcaacttgc aaaagtttca 2989201 ttttaaatgc atattaactc gttagaaagt ctctctcata tattgatatc gggtaataac 2989261 agtcctttat aaatgtttat ttgtgaaaat ttttttaatt tcttgtcaaa aactcatttt 2989321 ttatgtgact tatgatccat aatctcttta agcacaaaga aacaggagat gaaataccat 2989381 ctcctttaat tgacaaataa tgatttcaat gctgtttgaa gctgcaaatc atttttttca 2989441 tctgattttt tcttttctat ctgctgattt aatgtctctg cagtgcgagt gtcgatcaca 2989501 ccggttttat tcagcttgtt ttgatcctga aaagccataa ccgctttttt catgtctttg 2989561 ctgaaatagc catcctcacg tcccggatca aagctgagac cttttaacaa tacctgcgca 2989621 tgcttgacgt cttcattgtt catgtccact ttaagcggct ctttcagctg taagggcccg 2989681 gcggaaaaat aatcgggctg cttaatcgca atggtcggtt caattccttt cttatgaatc 2989741 cagtttccat ttggcgtcag ccacttgtaa agcgttaatt tgatgttgct gccgtccccc 2989801 attggcacag cctgttgaac cgttcccttt ccaaaagacg tatcgcctac aacatcataa 2989861 tggccagctt cctttaatgc gccggcaaga atttctgatg cagaggcact tcctttatcc 2989921 gtaatcacat tgacagggta cgctttttta tgggtcaatg ttgaaaaata acgtttttta 2989981 tctccattgc gttcagcaat ctgaatatac ggctgatcct ttgtaacgaa atgcttaaga 2990041 atttcttcca cactttgaag atatccaccc gggttgccgc gtacatcaat gacaagtcct 2990101 tctatttctt ttttctcaag ctccctcagc gcttttgcaa aatcctctgc ggtgtgctca 2990161 gaaaaagtag agatggcaat atatccgaca gaatgcccct gtactttttt ctctgatgca 2990221 aaaaccgttt cgagcggaat ctcagctctc ttgatccgga atgacaactg cttcttcgtt 2990281 ccaggccgct gaatcttcat tgaaacgctg gacccttttt ttcctcttat ttttaacaca 2990341 gcgtggttta aatccttgcc ggccatcgat tctccattga tgctgataat ttcatcatta 2990401 ggcttcaacc cggctttttc cgctggcgat ttcttgaatg gagaaacaat aataattttg 2990461 ccgtcttcca ttccaacctc agccccgatg ccttcaaatg aggaatcaag agaatcagaa 2990521 aattgcttag ctgtctgctt gtccatgtaa acagaataag gatcatttag cgtagacagc 2990581 attccctgga tggctccctc gagcagcttt tctctatcta ctttttctac gtactcattc 2990641 gaaattaact catacgcttt ttcgattttg tccatagctt tatcccgttc agagtcagct 2990701 tgtgccgtcg cgggaactgc tgcagtctgg ggcttatcca tctcaagcag gttgattccc 2990761 gcatatacac cggcgcctcc gaacagcatg ctccctgctg ctatcacagc cattattttt 2990821 tgattcatcc tttactcctc ctgtatgcca gactgtcttt accaaaacct agagatagta 2990881 tatgtaaagg atggagattt catgtaatca tagaagaaaa agaaggcaaa tgaaaagccg 2990941 tcccgaaaac ggaacggctt tttcacttta tactcgcaga aacttgcgga tggaagtcag 2991001 acttccccat actccaatta ctgcgccgat tgcaatcagc actagcgaaa cttggaatac 2991061 aaatggatta taaggaagaa gagagacaaa tgatccttga acctttggaa cgacccatcc 2991121 gatgacgtat tggtaagtgc tcagcaccag tgcaatcgga atcacagaac cgaatacgcc 2991181 tagcagcaat ccttcaagga aaaacggcca gcggataaac cagtttgtcg cgccgacaag 2991241 cttcatgatt tcaatttctt ttcttcttgc gaaaattgta attttaatgg tgttggaaat 2991301 taagaacatc gccgtaaata ccaggccgat aattaacgcg attccgatgt tgcgggaaac 2991361 gccgaccact ttaaacaaac ggctgacctc ttcttttcca taagtgactt tataaacatg 2991421 atccattttt tcgatctttt tcgccacgtt cggcgtatca tgcggatctg tcgttttgac 2991481 gacaaacgca tcattaagcg ggttttcctg atccttcatt gtcagggatt ttccgctgtc 2991541 accaaaactg tcaaccagct ggtcaagctc tttttcttta gatgaaaaag tgacactctg 2991601 aatgcccttc agttccttaa tatcgttctg aagcttgtcc tgtgccttct gatctgcagt 2991661 cagatcaatc agcactttga tttcgacttg tttttctgca ttcgtggcca tgttattcaa 2991721 attcagcata atcactaaaa acacgccgac taaaatcagc gtaacggtta cagcactaat 2991781 ggatgcaaat gtcatccatg tgtttctccc gagagattta aaactctcac gcaagtggcg 2991841 cccgagaatt ttaatcatat gaaccatact cccctcttga ctcatcacgc acaatgatac 2991901 catcttcgat tgcaatgaca cgtttcttca tggtgtttac gatttcttta ttatgtgtcg 2991961 ccatcacgac tgttgtcccg cggttgttaa tttcctccag cgtcttcatg acttcccagg 2992021 acgtatccgg atcaaggttt cctgtcggtt catcagcaat gacaacatca gggttgttca 2992081 caattgatct ggcaatagat acacgctgct gctccccgcc tgaaagctgg tcaggaaatt 2992141 gtcgcgcttt atgcttcagc tgcacgagat caagcacttc aagcacccgt ttcttaatga 2992201 cagacggctg ttctccaatc acttcaaggg caaatgccac attttcaaaa acagtaagtt 2992261 tcggaagaag cttgaaatcc tgaaagacaa cacctatttt gcggcgcacg aaaggaatct 2992321 ctttttcttt aattgtcgcg agatctttat gattgattaa aatttgtcct tttgtcggtt 2992381 tttcttctct gtaaatcatt ttaataaaag tagatttacc tgctccgctc ggaccaacaa 2992441 catacacaaa ctcgccggga tgaatggtaa cagaaatccc attgagtgct tttacgccgt 2992501 tcggataggc tttatatact tccttcatct ctatcatgaa atcacctaat cttttatatc 2992561 attttatcta tcacacggtc atactcttcg aatgcattcg acaatttatg acccattcat 2992621 ttgtaaaaag atgaaaaatc tgaaagttcc ctttttcaat acacttcatt atacgtcaaa 2992681 tttagacata atactattac agtttctttt cattcatatt gtcaaggcat aaaaacatcc 2992741 ttgccagcac tcggcaagga tgtttttatc ttactttttt tctgacagcc atttggcaat 2992801 aacagcggct tcgttatcat ctacaagccc ctttggcata ttgccgcggc cgtttttaat 2992861 aatgctttca attttgtgtt catcgtattt gcctccgacc tcttggagat taggccctga 2992921 cacaccttct aaatccttgc cgtggcagcc tacgcagctt tgctgatata attcttcccc 2992981 ttcagatgca gtggcttccg tcttgctgcc agtgtctgtc ttctcttctt ttgcatcgtt 2993041 tgatccgcag gcagccaaca gaacagaaag cgcaaatcca atcattagta tcgataactt 2993101 tgatttcatg ttgagaagca caactccttt acgatctctt ccatattata acctcgttta 2993161 agcgcgtttg aaaccctcgc ccagcacctc gctcgcgtct gctacaatta caaaagctga 2993221 ctcatcaatc tgtttgacga tttgtttcaa tttggtgaat tcagtttgcc caaccacgca 2993281 cattaaaatc ggacggtcat cgtcagtata tccgccgact gcagaaattt ttgtcacgcc 2993341 tctgtcaatc ttctgtaaga cagcctcctt gacagcctgc tcctgctttg taatgatgag 2993401 cgccattttt gaacgattaa agccgacttg cacaacatca atggttttgc tggacacata 2993461 gacgccaagc atggcatata agccttgctc aatattaaat acaatcatag ccgtaacaac 2993521 gatcattccg tcaatgatgg cgagacactt ccccaatgac agaccggagt acttatgaat 2993581 gatctgtgca gccaaggctg tacctcccgt cgaacctttc cctaagtaca caataccaat 2993641 tccgatacct atcccgacac cgccaaaaat cgccgccagg agttcatgat gagtggcggg 2993701 ctgaatatcc cttgtcagaa acactactag cggcaaaaac acagaacctg caagcgtctt 2993761 tagtccaaat ttcccgccga gcaaaatgac gccagcaata aataaaggga tattaataat 2993821 ccactgtaca tacgctgctt caaaaccata tgattgtaaa atcgtactga tcccgctgac 2993881 cccgccggcg gcaatcttat tcggaagcaa aaatacatta aaggacacgg ccgtaatcgc 2993941 tgctcctatc aatatgtata cataatcccg caaaatccac aatgttttat tccgtacgtc 2994001 catcatatat cctccgtttc ttccaatgct ctccgatagc attttaatcc ttccctgatt 2994061 agatgtaaat aacacccaaa tacagtggta atatgctaaa gcagcagtga aatcaaggat 2994121 ataagaaata aaaaaacaca cccgtatgca tcaggtgtgt ttttcagctt atgaaagctt 2994181 agaacgcagg taggcatcaa taaacgtatc aatgtcacca tccattacag cttgaacgtt 2994241 ccccatttct gtattggtcc gatggtcttt taccatggaa tacggatgga atacataaga 2994301 acggatttgg ctgccccagc cgatttcttt ttgttcaccg cgaatttcat ccagctctgc 2994361 ctgctgctct tcaattctgc gctgatacag cttggccttc agcattttca tggctctttc 2994421 acggttttta atttgtgagc gctccgtttg gcatgtcaca actacgttcg tcggcaagtg 2994481 agtaatccga acggctgaat ccgtcgtatt gacgtgctgt ccgcccgcgc cgcttgcacg 2994541 gtacgtgtca actttaatat cctccgtacg aatatcaata tcaatttcat cgttaaattc 2994601 aggcatgact tcacatgaaa cgaaagatgt gtggcggcgg cctgatgaat caaatggtga 2994661 gatccgcaca agacgatgaa cacctttttc tgctttgaga tacccgtaag cgttgtgtcc 2994721 tttgatgagc aatgtcactg acttgattcc cgcctcgtca cctggaaggt aatcgagagt 2994781 ctctacttta aagccgcggc gctctcccca tcttgtatac attctaagaa gcatagagcc 2994841 ccagtcctgt gactctgtac cgccagcacc agggtgcagt tctaaaatcg cgttattttt 2994901 atcatacggc tcgctgagaa gaagctgaag ctcaaactca ttgaactctt ttgttaatga 2994961 ctttagttct ttttcaagct caagctggag atcagtgtcc ggctcttctt tcaaaagatc 2995021 atgagtcatt tgtaattctt cgtgggattc attcaatttt ttatacgaat tgacataatc 2995081 ctttaaaccg tttgcttcat ttataaccgt ttgagctttt tgctgatcat tccagaattc 2995141 cggatcagcc atttgttcat ctagctcagc aatgcgggcc tcctttgatt cgaggtcaaa 2995201 gagaccccct aaagtccgct aaacgagaag ccatattttc gagctctgct ctaatttctg 2995261 ataattccat ttcattcacc tcattaaaag atccgcaggc gcctgcaggc gccgcggtca 2995321 gtaaacttgc cggggcgaac tattcagtac ggccgcagca atttttatat tttttcccgc 2995381 ttccgcagtg gcatggggca tttcgtccga tatcaaccac tttgcgaacc ggtgctttct 2995441 ttgctttttt gttatcgtcg ccttcttgcg gctgatgagc tgttgtttga ccttgtacaa 2995501 cctcttcacg ctccagattg ttttcaatct cagctttcat cacaaatttt gcgacttcgt 2995561 cctcaattga ttcaatcata tgctcaaaca tcgcaaaacc ttccatttga tactcacgaa 2995621 gcgggttcgt ctgcgcgtaa gcacgaaggt gaatcccttg gcggagctga tccatcgcat 2995681 caatatgatc catccattta gaatcaacgg cacgaagaac gataactttt tcgaattcgc 2995741 gcatttgctc tttgccgaat tgctcttcct tctcattata ttttgtgatg atgcgatcca 2995801 taatgagctc aagcatttca tccggttctt tgccgaagat atcgctcttc tcaagtgcac 2995861 cttcatcaag ataagttgtg ttgataagat caactagacc gtcaagcttc cactcctcag 2995921 gaagctcttc tcttggcgta taggctgcaa ttgcgcgttc gagagaagac ttgatcatat 2995981 tttcaacgat ttcacgcagg ttttcagagt caatgacttc aaagcgctgc ttataaatga 2996041 cctcacgctg ctggcggaga acatcatcat attgcagaag ctgtttacgc gaatcgaagt 2996101 tattgccttc gacgcgtttt tgagacgatt caaccgcgcg agataccatt ttgctttgga 2996161 ttggagtaga gtcgtccatg ccgaagcggt caagcatcgc cattgtccgc tcagctccga 2996221 atctgcgcat caattcatct tccatagaaa gataaaattg agtaatcccc gggtctccct 2996281 gacgtccgga acgacctcga agctgattgt caatccggcg tgattcatgt cgttctgttc 2996341 cgactacagc gagcccgcca agctctttta caccttcgcc aagcttaatg tccgttccgc 2996401 gccccgccat gttagtcgca atcgtaactg cgcctttttg gccggcctct tcaatgatct 2996461 gcgcttcacg ttcatggttt ttggcattta acacttgatg cggaattcct ttgtttttaa 2996521 gcagcttaga aatcaattca gatgtttcaa cggcaaccgt accgactaga acaggctgtc 2996581 ccgtcatgta acgctgtgcg acatcctccg caactgcctt aaactttcct tccatcgtgc 2996641 ggtaaattaa atccgggcgg tcatcacgga caacaggcct gttggtaggg atcgtgacaa 2996701 cctgcatgtt gtagatgttg cggaattctt cttcctctgt cttagctgta cccgtcatac 2996761 cggcaagttt ttcgtacatt cggaagtagt tttggaacgt aatcgtcgcc aaggtcatgc 2996821 tttcgttttg aatctcaagc ccttcctttg cttcaatcgc ttggtgaagc ccctcactgt 2996881 agcggcggcc tttcatcaga cgtcccgtga aggaatcaac aataacaacc tgtccgtctt 2996941 ccactacata gtcaacgtcc ttttgcatcg caacgtgagc ttttaaggcc tggttgatat 2997001 ggtggttgag cgcgacatgc ttcacatcaa agaggttatc gatgccgaat gctttttccg 2997061 ccttcgtcat tccttcttca gtaagctgta cagcttttgt tttgatatcg tacgtgtaat 2997121 ccttctccgc ttttaacgtg cggacaaaag catttgcctg tacgtacagc ttagtggatt 2997181 ttgcagcttg tccagaaatg ataagcggtg ttcttgcttc atcaattaaa atagagtcaa 2997241 cttcatctat taccgcaaaa tgaagcgggc gctgaaccat ctgctcttta taaagaacca 2997301 tattgtcacg caaatagtcg aagccaagct cgttgtttgt ggagtaagta atatcagcgg 2997361 cataagcttc ccgtttttcg tcttttgaca ttgagtttaa attcaaaccg acagtcaaac 2997421 cgagaaactc gaaaattttc cccatttgct cagcgtcacg gcttgccaag tattcgttga 2997481 cagtcacgac gtgtacgcct ttaccggtta acgcatttaa ataaacaggc agggtagacg 2997541 ttaatgtttt cccttcccct gttttcattt ccgctatatt tccgtcatga agcgccacgc 2997601 cccccatgag ctggacttta aacggaaaca tgcctgttac gcggcgtgaa gcttctcgaa 2997661 caacagcgaa agcttcaaca agaagatcat ccgttgtcgc ccctttttca agacgctctt 2997721 taaattcaat tgttttatgt ttcaatgcgt cgtcagagag attttcatag tctccgcgaa 2997781 tcgcatcaat atcgttagca attttttcgt atctattcag cgtacgtttt gttggatcaa 2997841 acattttatt taaaattcca agcatttata acgctcctct atcatcacac gcctatttta 2997901 gaggcatgta taaataattt actagtccat gtatacctct cattatcata tcataccttt 2997961 tgttatttcc aaagaatttg caaataagaa aaacaaaaac cttccgcgga catcacggaa 2998021 ggcttctctt cattattcag tcggttcaat taagccatat ttcccgtcat ttctgcggta 2998081 cacgacattt gtaaggtttg tttccgcatt tgtgaaaaca aagaaattat ggccgagcat 2998141 attcatttgc aagatcgctt cttcactatc catcggcttt aaattaaagc gtttctgacg 2998201 gacgatgtcc aagctctcct cctcttctat gtcatcctga accgcaatat ctgtatcaga 2998261 gccaagaccg tttgccaata aatattttgg agagccctgc tcacggaatt tacggtttac 2998321 tttcgtttta tgcttacgga tttgacgttc cagtttgttt gttgcgagat caattgcgtt 2998381 gtacatatcc tcgttatgca cctcggaccg aagcgccaga tctgtcatcg gaatcgtaac 2998441 ctcaacctta gactccttgt cattgtaaaa cttcaagttg acgttcacat cagcatccac 2998501 gctatggtca aaatagcgct ccagcttgcc gatcttcctc tcgacatgat cctttaacgc 2998561 gggtgtcact tcaatatttt ctcctctgat gttatagttc atcaaagaac gcctcccttt 2998621 tattaaggat atgtatctat ttctctttta ccctttacaa ttcctgctga aacataaatc 2998681 ttttgtgaaa attcagtgaa ctttgtcgaa ttttgtttgt atttgctctg ttattggcgg 2998741 ctgctaagct tttgaatcaa acagtttcat tttgctactt ttcggcagct cagctttaat 2998801 tgatttgctg taattgaagt tattttcctt aggaaccagc atatcgtacg aaatagagat 2998861 gaattgcagc gcgtctcttg tcagctgcct attcatctca tttacttttt tcagacgtcc 2998921 gagaacttga gaaagagatt cgtatagttg ttccagctct tccttttcac tgcctgaggt 2998981 tttggcgata catgcggaaa tagtattatt ttcgctatat ccgagaaagg ccgaagttgt 2999041 tttgatccgg tcatcttctg tctgcgtgat tgcttgaata tatttttgct cttttgtcaa 2999101 aatgttagaa agctcttttg ttttgccggc tttgagcgct tccgtctttt cttcagacag 2999161 cgtgagcagg tgctcatgca gaacgcaaag tcgcttcaat tgttcaataa ttgccttcgc 2999221 tgacatgggc tttctccttt tttattgctt tttataaaaa ttaatcatat ttttcgcaat 2999281 atgatttgcg tctactttgt atgacccgtt ttcaatttgc gctttaagct gcgcaatttt 2999341 ttcctgtcgt gaaccagtga ctgcgtcgga tgcatgttgc atttctttag cctgtgatga 2999401 aatttcaatt ttatcttgag gttgtgcaac agttttttgc accgcttgct tatcataatt 2999461 tttttgatat ggattaacgg attgtgttcc aaattgattg attttcatag gattcctctc 2999521 gctttccgtt gcagtcttta aacaatctta acccttttat cgactgcgtt ttcagttagt 2999581 ttagggaatc agctgttttt ggtattatag gcatagtatg tgtctttttt actattttct 2999641 ttctcgattt tcagagcatc ctcgtggttc aaatgatcca tttgatcctt aatatcagac 2999701 tggcaagcct tgcagaactt gccttctcta atcgatgtcc cgcacctttc acaagggtat 2999761 gccaaattag gaagatgagt gatctgaatt cgcttctgcc tgatgaattt caatatcagc 2999821 tcttcttcca cacctgtttc ctcagttatc cggctcaaag ttgattgccg gttttcctgt 2999881 tttcttaaaa atttatagac agtctcaaat gatttttctt cttccttaat acacgcctga 2999941 catacggttt gcagctttgt ttttaaaaat aaagcattgc atttcggaca attagccagt 3000001 tctcccatct ttttttctcc ttattagata atatgcctgt gtcaatttct agtgattata 3000061 tcggcataaa aacagaatca tttagcttct gatcaaggta aaagatgaca ctgaagcggc 3000121 ttttcctttt tctaataagc agcgggctgc gaagtgcaag gtggcgcctg ttgtataaag 3000181 atcgtctatt aaaatgatat tcataccttc tgctgaatta ttttttgtat caaaaatgca 3000241 ctctgacagc aggcgttctg ttttcttttt ctttgactgt ttctcattat tcaggcgaat 3000301 gaggggatgg tgggaaggcc ggtctaaaca ttctgccaag agatgtgcct ggttaaatcc 3000361 gcgctcttct tcccgttcct tgctcagcgg aataggtaca agaacaaaat gcttatcggg 3000421 gtaaacctta gaaaaggttg aagaaaaatc acttttaaat gcatttatga tttctgcatc 3000481 tcctctaaat ttaaaacggg agagcgtttc tttcatcata tcattatatg tgtaaactga 3000541 acggttttga cgcaatagca aactgtctct gatccttgtt ctccacacct cgcaatccct 3000601 gcatacggca tgaacagatt gaggtctgcc gcacaggggg cagatatgtc ctgtgatttt 3000661 ctttaatttg cttctgcaag aataacaaac cttttcatca ggctttagta aaaaaagggc 3000721 tctccatgta acatcttgag aaaattgcga atcacataat aaacagatca gtttatgaat 3000781 gcctcctcct gcttcgtttg acataaatcg cttggactct ctgaaactac tgcagcagat 3000841 tcagccaaaa tgacaagcat tgctgtgttt ttttgtttat ctaccagctc agctttcgta 3000901 tatgcgatct ttttaaaatc agtaacgtag gatggactca ctttgtttaa agaaagtgcc 3000961 aatacatcgt tttggcatac ttggcaagta caggccatat gaagctggtc catatatcgg 3001021 tcgagcagtt ctttcattac gatttctttt gaattgacaa gcatttttac agctcctcat 3001081 catcggttat atgagtatac tgtaccacgt tttcaaataa tggctagtct gtacattcaa 3001141 cttttgctgc caattcattc atttctttta tatgctttct tgcatcgagc atactctttg 3001201 ttttgccgaa gtgaaagtaa atgacatcgc cgtccgcata ttctttatgc cggccggttc 3001261 ttcctgcaat ttgaacaagt gcgctttccg taaagataga cgattccgct cctagtacac 3001321 ccgtttgcac cttggggact gtgacgcctc tttccagtat tgttgttgtg attaatagat 3001381 cgagctgacc atctctgaat tgctgcactt tctcctttct atgcttgtct tccgcgtgca 3001441 cagatgcggt tcggcaatga acacctttaa agcacgcagc agccttttcc agaatagaaa 3001501 cggaaggaac gaataaaaaa acaggcctcc cttcttttac atgaaactct atccatcttt 3001561 tcaccgctgg cggaatttta tttcggttta atttcttctt ccagtttcca caccatacaa 3001621 agcgcggttc gggtaaaggt ttccggtggt gtcttgcggg gatgcgaact gaatgtaact 3001681 gtccgttcag tgcttttctt tttaattctt taggaggtgt tgcacttaaa taaacgaggg 3001741 tgctgttttt ctttcttgct ttttgaacag cgaattgaag ggtttgatca gcagaatatg 3001801 gaaaagcgtc aacttcatca atgatcataa catcgattgc atctttatat cgcaaaagct 3001861 gatgcgtagt ggaaatcata agcggagata gccgcccttt gtcatcgctt cctccgtaaa 3001921 gcgctgaaat gtcagcaccc tgaaaggcag ccttgagtct tggagcaagc tctaatacaa 3001981 catcggtgcg aggtgttgca atacatacac gcagtccttg atttaacgct gattctatac 3002041 caggaaacag catttctgtt ttgccagcgc cgcaaaccgc ccagatgagg agctcttctt 3002101 tttttgatat tgcttcaatt aaaacattgg cggctttttg ctgtccgctt gaaagcttgc 3002161 catcccatgt cagcttaata gacttccagt ttgattcatt ttcctctttc catgaatata 3002221 aaggaacctc ctcactcact ctgcccatca tgacacagga acggcaatac agcttattct 3002281 ttccagatga gtgataaaaa gaaaaatacc gctgatcagt ttgtccgcac ctattacatc 3002341 tatatctccg tttatttatg gatatagaat tttcagcagt gatatatcca ttcttgatat 3002401 gccattcaat catctcatcg gaaaatgaga gctcagtcct gagcaaatga cggcttcgaa 3002461 gcgtctgctg caattctttt gaaaaggaac tgtttttttc aactggcaca ttcacatagc 3002521 acgcctcctt tcgaaacagt atgcctgaat gaatattttc tgtccaacta ttaaaataag 3002581 aatataaaaa aatctccgct ctaaaaacgg agatttggcc ttatttaaaa caccagcaaa 3002641 ttcctaacgc accttcaccc aaatgagtgc cgattaccgc gccaaaatag ctgttataaa 3002701 attcaacatg aggatatttt gcagaaagct cttcaatgat tttcgctgct tcttcctctc 3002761 gattagcgtg gataacagca gctcgcatag gcaacccttt actcgcatct tcgtctaaaa 3002821 gctcataaat tcgcgaaatt gcttttttac gtgtgcgaat cttctcaaaa ggcacaatta 3002881 ccttattgtc aaaatgaagg ataggcttta cctttagaag actaccaatg aaggcttggg 3002941 cgctgcttaa tcgcccgccg cgctgaagat gggctaagtc atctaccata aaataagctc 3003001 gaactgtttt tttcatttct tccagttctt ttataatatc ttccggcgat gatgctccgt 3003061 ttttgattaa ttcagcagct ttaagggcat aaaagccttg agccaagcag ctgatctctg 3003121 agtcaaatgg atacacatca atattgtcga ccatcgaatc agccgctgct gcactgctga 3003181 atgttccgct gatcccgctg gaaagatgga tactgataac cgcatcataa gacttgccaa 3003241 gctcttcata caacgcaacc agctcgccga ttggcggctg agaagtcgtc gggagctcat 3003301 tatgtttttt cacttcttca taaaagcttt tccagtccaa ctcaatttct tcacggtaag 3003361 tctcctccct aaaaacaacc tggagaggga tcatatgtat ctgatgttgt tcacgcattt 3003421 ctttcggaat atatgccgtg ctgtctgtta cgactgcaat attcatagct tcgatacctg 3003481 ccttattgct ttataactct attgtaaggg aaacggcagc ctaaaaaaag acctgcctag 3003541 taaaaggcaa gtctcctatt atactatctc atttctaccc agccattttt aatggcgacc 3003601 acaacggctt gcgtccggtc gtttacattc attttttgta aaatattgct gacatggttt 3003661 ttaacggttt tctcactgat aaacaatgat tcaccaatac cgcggttgct ttttccgtct 3003721 gcaagcatct gcagcacttc acattcccgc ctagttaaaa tatgtaatgg tctgcggatt 3003781 tcagggtaaa cctcatgttg agggtgtgca gaaactccgc ttgttgcaag gcggcggaat 3003841 tcgttaacga ggttgtgagt aaccttcgga tggaggtaag atccgccctc agccactact 3003901 ttaaccgctt caattaatgt atcagcatcc atctctttca gcagataacc tcttgcacct 3003961 gttttcaggg catgtgttac ataattttcg tcatcgtgaa ttgatagaat aattacttta 3004021 gattcaggat acagctctac aagctgtttt gtagcttcca caccatttac gtttggcata 3004081 ttgatatcca tgatcacaac atcaggatga tagtgctcaa caatacgagc cgcttcgtcc 3004141 ccgtcatcac cttcggctac cacttcaaag gtaggttcaa aatccaatat ccgtttaaca 3004201 ccttcacgaa ataactgatg gtcgtcgata ataacaatgt ttactttagt cacaagccac 3004261 gcctccttgt attattgttc tatatactct agcattcggt caatatgcct tttggctcta 3004321 ttttacaaat catagtcaaa gagataacgg aaccttaatc ataataaatg tcccaagacc 3004381 tattttcgaa tctattgtca tcgttccttc caataaatct actctttctt tcatgcccag 3004441 caagccgaat gatttgtttt tcttctcttt cgcttccttc aggtcgaacc ctttaccgtt 3004501 atcttttatc attaaaatca caaaatcctt tgtgatctca actttgactg taatttcttc 3004561 agattcagaa tgctttagcg cattagacac agcttcctgt gcgagcctga agagcgcaac 3004621 ctcaaactga ggcgctagcc tctgatcctc tgtttctcca atgcactgaa aatgtatttt 3004681 gaccttcccg ttatattcct cggttgtata tagatatttt cttaaagttg gaatcaggcc 3004741 taggtcatca agggccatcg gtcttaaatc atatataatc cttctcactt cgtaaagggc 3004801 attccgaaca ttttggcgga gatttttaat ttcttggaat ccgtcctctg cgccccggtc 3004861 acggaaaatc cgctcgatta attccgatct catcataaca ttcgccagca tttgagcggg 3004921 tccgtcatgg atttctcttg agactctttt tcgctcttct tcctgcgcct caataattct 3004981 taagccgaaa tcctgttttg cctgagcatc agcaagaagc agtccaactt cgcgcaaatc 3005041 ctgattcaag tagttgagca caactgtaat ttggcttact aatgattctg accgctcaat 3005101 gatttcctga agccctagca atctgcgctc caaatcgtcc cgccgttcgc gcaattgctt 3005161 ctcacgctgc tggatcatcg tcaattctac ctgcagctta tgggcttttt cataagcatt 3005221 gcggatttcc tcttcactga atctatgaaa attacggctg acctcggata aacggtttct 3005281 cgcatggcga gtttgcactt caagtttatc gccaagctca atcacttcat acacctgctg 3005341 tttaatttgt ttcagttctt cgaccagctg ttcatactgc tggcgtgact gctccccgat 3005401 ttgaaaaacc tcgtccttgc tcccgtcaac ggttttcagc atcttcatca aaatagaatc 3005461 cagcactttg gaatccatct ttgttttatt cataatttcc ctccgtcacg gcgttgtcat 3005521 atatttttat tataaatgta attgatctgc aaattatgtc gaattataat gaaagaatgc 3005581 gtatattcta gaaaaaaaca tttttatata ctatctactc tttatgatac caaaatacgc 3005641 acaaaaattc taaagactgt acgaatttgt ataggcagtc ttttatgctt agcaggaggg 3005701 tcagctagca tgctgcacag ctattttact gtgaaagaag cgggagaaca cgagattgtt 3005761 atagaaaaat cgcgttttat ctgtcattta agccgtgttt ctaccgaaca agaggcacag 3005821 gaatttatac agaaaataaa gaaacagcac tggaatgcga ctcataattg ctcggcttat 3005881 gttattggcg agaatgatca tatccaaaaa gccaatgatg acggggaacc aagcggtaca 3005941 gcgggagtgc cgatgctcga ggttttaaaa aaacgcaggc tgaaggatac ttgcgccgtc 3006001 gttacacgct acttcggagg cattaagctt ggtgctggcg gattaattcg cgcttatggg 3006061 aaatcagtgt ctgaaggatt aaatcatata ggtgttgtag aacggaagct tatgcgaatc 3006121 atgcatactt ctgcagatta cacatggctt ggcaagattg aaaatgaatt aagggagtca 3006181 caatttctgt taaaggaaat ccattattca gaaaatgttg aattcgaaac atacgtggaa 3006241 gaaaaagaaa ccaacgcttt ttctgaatgg atgacagaac tgacaaatgg aaagagtgat 3006301 attaaagagg gagagttgac gtatcttgaa aaagccgtca atcacataaa ggagactgaa 3006361 taatggctga acgcgttaga gtgcgtgtgc gaaaaaagaa aaagagcaaa cgtaggaaaa 3006421 ttttaaaaag aataatgtta ttgttcgccc ttgcactatt ggtagttgta gggcttggcg 3006481 ggtataaact ttataaaacc attaacgctg cggatgaatc gtacgatgcc ctatcccgcg 3006541 ggaataaatc aaatcttcgc aacgaagttg tagacatgaa gaaaaaacca ttttctattt 3006601 tatttatggg aatagaggat tacgcgacta aaggacaaaa agggagatca gactctctta 3006661 ttgttgttac cctggatccc aaaaataaaa ccatgaaaat gctgagcatt ccgcgtgaca 3006721 cacgtgtgca attagctggt gacacaacgg gaagcaagac gaagatcaat gccgcttaca 3006781 gcaaaggcgg taaagatgaa acagttgaaa ctgttgaaaa cttcttgcaa atcccgatcg 3006841 ataaatatgt cacagttgat tttgacggat ttaaagatgt gattaatgaa gtcggcggta 3006901 ttgatgttga cgtgcctttc gatttcgatg aaaaaagtga tgtagacgaa agcaaacgga 3006961 tttacttcaa aaaaggcgag atgcatttga acggcgaaga agccttagca tatgcccgga 3007021 tgagaaaaca ggataaacgc ggagactttg gccgtaatga cagacaaaaa caaatcttaa 3007081 acgcgctgat tgaccgcatg tcaagtgcaa gcaacattgc taaaattgat aaaatcgcag 3007141 aaaaagccag cgaaaacgtt gaaaccaata ttcgcattac tgaaggttta gcgcttcagc 3007201 agatttacag cggctttacc agcaaaaaaa tcgacacatt gagcattaca ggttctgatt 3007261 tgtatttagg gcctaacaac acatattact ttgaacctga tgctacaaat ctcgagaaag 3007321 tcagaaaaac gcttcaagag catttagatt atactcctga tacaagcact ggcacttccg 3007381 gtaccgaaga cgggactgac agctcaagca gttctggcag cactggcagc actggcacaa 3007441 caactgacgg gacgacgaac ggaagcagct attcgaatga cagcagcaca agctcaaaca 3007501 acagtacaac gaattcaaca actgattcat cctattaaaa aatgcccggt ccttttagag 3007561 gatcgggcat ttttgcgcag aaaaaaactc cggcacataa gccggagttt ttaattcctt 3007621 ttcaccagcc gtttataaaa ctttgtaaac ggcttaaatt tttcattcac gagtcctgtc 3007681 acttctgcta tgatttgcat aaaaataatc aaaatgaaga taataaacaa agaaagccaa 3007741 attgtggcac ttttaagtac aatcgcactg atactgaaaa taaatccaat taaataaata 3007801 actaagaccg acatccgatg tgaaaggcca aaggccatca gtctatggtg aatatgcgac 3007861 ttatcaggcg ctgaaatcgg ctgtttgttt aatattcttc tgatgatagc aaatgttgta 3007921 tcaaaaatcg gtacgcctaa tataataatc gggataacga tactgaacaa tgtgacactt 3007981 ttatacaggc ctaataatga aagaatcgag atactatacc ctaaaaacag tgatcccgta 3008041 tctcccataa agatttttgc cggatggaag ttgtaaaaca aaaaccccag cgtgctggca 3008101 ataacgacta atgagagtga cagaatgagc acttttccgc cggatagcgc catgacagca 3008161 atcgttgaca ggccgataac agaaagaccg gcagcaaggc catccaatcc atcaatcagg 3008221 ttaattgcgt tcgtgatgcc gacaatccat aataccgtca gcggataagc catccatcct 3008281 aactcaaatc gttctgttaa aaaaggtact gagaaaaagt ccatttttaa gccagtgctt 3008341 acaatcataa tggctacacc taattgaatc aaaaacttaa cttttgcact taattgatat 3008401 ttatcgtcaa gaatacctaa cacaataatg atgaatgctc cgactgtaat tgccgtcatc 3008461 cttgtttctg tgtaaatacc ggatgcaagc acgcctgcaa ccaccccgat aaatatggcc 3008521 agcccgccca tgcggggcat gattttgtca tgtacttttc gattgctggg ctggtcaact 3008581 gcacctattt taatcgcaat cctttttacg attggggtta tgattaaaac tgtcagcagc 3008641 gagacaataa acgcaacaac aatgcgaatc atgcgttcgt caagcataaa gaagtctcct 3008701 ttggaattaa atgaagtctt tatttatata gagaaccgtt ccttccatta taccttctcc 3008761 ttagttatta taacaagctt catcaaaaag aaacacgtat aatcaaaaaa cgcgcatccc 3008821 aatttatagg actacgcatg tttttgaatc cctgtatatt tcataatttg tctaaataag 3008881 caattccaat cttgtgtccg ggcgatgttt cggcgcattt ctttataggt ctcgtctccg 3008941 ttttgaccga gaactttttc acaagcggct ataaaatcaa tcggatgatc gccctctaca 3009001 tattcgtata catacggctt ttgcattttt gaggttgacg gaagattagt gcctacaaca 3009061 ggttttcctg ccgctaaaaa ttcaaatagt ttcagcggaa acacagcttg attatacggt 3009121 gattgtttat atggcataat gccaatgtcg ataagctcca tataatgagg cacttctttt 3009181 ggatctgccg gaccggtcca tatgacattg ggaagcctca gcagctcttg aaacgaaaca 3009241 tcaccattgg tggcatccgg gccaacccat aaaaatgtcc aatcaggctt ttgcagtgcc 3009301 gcttctttaa tcattttaaa atcgagcttc ggtttaatcc cgccaataaa acctaacact 3009361 attccttctc tcccctgcag tatactgcga tcgggagctt gtttatttgc agaaaacagc 3009421 tcatactcca caccgttttc cacagtatga accttttctc gtcctgcagt cagttttttg 3009481 tctacttcct tgtgaagata atctgatgaa caggttattg aatctgctcg ttgtataatt 3009541 ctcagctctg ccgatttaat gacttttcgc cggaattcag acagcagatt tgatcggccg 3009601 ctgatcggcg cagcccatag gtcactgcag tcataaatga cctgatccca agaatacagc 3009661 gaagacagca gcgggaatcc gggaaacgtg taccataaac agcagcgttc accgtttgca 3009721 gaagcaggtg taagctcatc gagtaatggg gagagcttat gtctgtaaaa gacatctgta 3009781 tatcgtccga aacgaaacat ttttttctgc agcaggtctt tgacagcgaa ttgcctgatg 3009841 ccagaatgga cttcctgaaa ctctttccct tgggcacgcg gagccggaca tacccaaata 3009901 acttccttcg tttcctcctg agcagctaaa aattctgcca gccggtgcct tctgtatctc 3009961 aattggtctt ttccccattc agcagtggca acgatgacat gaatgattgc ttcttttgtt 3010021 tccaccttca tcaccttttc tctctgtttg cagctataat ctttttttca ccgcgttttt 3010081 tgcatattga acaaaacacc atgttgcttt cataaaatga agccgttcga tctccctgta 3010141 gacaaaccac gtttttttcg cagccttcca tttgttgctg gaaattgaat tattgacaag 3010201 ccgatattca gccaggcatt cattcattcc ataggcagta aatccttttt ttaaaagaga 3010261 cagccatgtg gctaagtcct gtctcgttct gatattcggc atttggatct gtcccgtttg 3010321 ctccctgtca atcatcaccg tcaagcagcc gataattgta tttttcaggg cgtcatcgta 3010381 cgtcaggctt tccggcgcat gaataaattt atcgagcggg gtcccgtcct gcgccattaa 3010441 gctgtagccc gtgaaagaga acgcacagga gcgctccatc ataaactcaa gctgcttttc 3010501 cagtttgtct tttttccatt tgtcatcact gtccaaaaat gctacgtagc gcccttgagc 3010561 gcgttccaac gctttgttgc gagcaaccgc agctccggag ttctcttcca gatacaccac 3010621 atgaattctt tcgtctattt tttcatactg ctgtaaaatg tcgcgggtcc catccgttga 3010681 gcaatcatcc acgataatca tttcccaatg aggatggctc tgatctaata ccgaatgaac 3010741 cgtgtcttca atatagtcac gcgcattata ggaaggtgta atgacagata cgagaggttt 3010801 ccaattggtc atgatcacat ctccatcgta tgattttaaa aggattctct gaaaaattca 3010861 ggaatgacaa cgaacataaa ggcaatcgta aggccaatca taacgccgag aactgctttc 3010921 tttttcggag acataccgcc gcctgctgtc tcacttacgg tttcggaatc agtaacactt 3010981 gccgctttca ggttaagctg tgtgtttttg agttcatata aaaatctctc tttatccact 3011041 ttggaatcct cgctcaccga ctcgccttca agcgcgtcta tgctgctgcg gatgacggct 3011101 tctctttctg catacagctt ttgatcgttt ttgaggaagg tggaggatat ggcgtttaag 3011161 acagattccg ttctatcctt atcctcgtca ctatagctta aagtcagtaa cgatttggat 3011221 tccgtattga ttgtaagctt ctctttgatc tctgctacat cttcatcctt ttcatcagga 3011281 agcgcctcct tcaaaaagga gtcgctcttt aatagaagcg gaatctcttc tgtgctgtta 3011341 taaaccggat gatcatagct ccccacagcc aaagtatctt cagctgtata gctcttttga 3011401 tcagcgatct gtgacggcag gatatacccc gccgcaccta atataattgg caccgctatg 3011461 atccaaatga tatttttttt tatgcgacgg gctattctta tcaatatatc gttcatataa 3011521 gtctccctgc tttttgtagt ctgtttatct gtacatcggc tcaggcattt gtctggatcg 3011581 ccttaacaca ttcacggcgg cgatgacgag cgccataaac acccaatgga aaaataaatt 3011641 tgaaacagag cttgggctga tacttgatac caggaaactg accatagcgg taataagtcc 3011701 ttctgtgatc agttttgact gattttctaa ttttctttca taaaacttgt aaagcaccca 3011761 tatgaggtag gcataaacgg acaaatatcc cagcatgatg aacaaaccaa aattagcaag 3011821 aatttcaaca agccagttat gcacctctgc cacattgtca gtatcatata cagcataatg 3011881 ctcaagataa taggatacat ttcctgcccc gactccgaat ccgtatgaat caaggaaaaa 3011941 atgccaagcg tttttcagca gatttgcccg agccacattt gatggaagcc tgtcatgaaa 3012001 tgaatgcagc gtctgcgggg ccagaaacag ctcccaaaac tttgaataga ttttgctggc 3012061 gaaaagaact gcgaaaagag caattcccgc cgccgacagc catatagcca ttctctttaa 3012121 aacaggcggc aatacaatga agatgtagac agcaatacct gcaaaaatgc ccagaaggct 3012181 ggctcttgaa ccagtggcaa aaattaaata caacgcacag agcgagagca caaggccaat 3012241 tgccttgatg tatccattct taatgttttt catcatcgtg atgtaaaaaa agaagctgat 3012301 ggataaaaag gtcgcaaagt cattttgatt aaaaaagacc gatgtcggat aatgctgctt 3012361 gtactccggt ccgctgtaca atgtggaact cgcaagatga tggtgggtga tatgattgta 3012421 aaaaccaatg atcatcagaa ataccgtcat caccagccaa atggcataaa caatcatcag 3012481 ccgctccatt ttttgcacgt acatgacaat aagataaatg aagaagatcc ccattgccaa 3012541 taaggctaaa tacttgaggc caactgttac cgacttggcc cacagcagag aaacaaggcc 3012601 atatataaac caaaaggcga aaaagagtaa aatccctttt acttgcagcc catgccatct 3012661 ttcaatatgg gttcgattcc gaaccatgcc gaaaatatga aggcaacccg ctgcaatgag 3012721 cagaagccgg taaaggaaca aactgaaaaa tccaagatga atggcaaaaa atgcattatt 3012781 taaaaaagtg caggcgatca aaatatagat tacagccata aagagccgtt cttttgttgt 3012841 aaatgcggtt gcaagcgtca gtaaaaacag gccaattgcc aacaccgcaa gcacagcagc 3012901 catctgcatg aaacctatat ctttatggat ggctcccagc aataggacga ctccaaatat 3012961 agcagcggcc agtaacgcta gcgtatggac cgctgatcgt ttgatactca catgtttaac 3013021 ccctttcctg atgtttcagg agccggcggc cgagcctagc agccggcagc ttcaaccaag 3013081 taacactttt tctttttata aattgacgct tcccaagtct ttagccaatt cttcaagcgg 3013141 caagcccgga aaatacttgt cagagggttc cgttccccga acagcgggac ggccgataga 3013201 gtgataaatg tatccggctg cctgcatctc ttcaagtgaa aataaatttc tgccgtcaat 3013261 gatgactggc tgttttaaga gggttttcac ttttacaagc tccatttctt tcacttccgg 3013321 ccaatccgtt aaaatcaggc atgcatcagt gtcttccatc gcagcataca catctgtgta 3013381 atactcgacc tgttcgccaa ggatcgctga agcttcagga atagcaatcg gatcgtatgc 3013441 ttttacatgg gcgcccagct gctgcagcat tgggataata tcaagcgctg gagcggatct 3013501 cacatcgttc gtattcggtt tgaaggctaa tcccaggact gaaatggttc tccctttgac 3013561 gcttcccata acagtcaaaa gtttatctac aatatgaaca cgctgctttt cgttcgtttc 3013621 aatgacagct tcgatgagct tgaatggata gcctgccgat tttgcgattt gaagcagcgc 3013681 ggttgtatcc tttggaaaac atgaaccgcc gaatccaata ccagctttaa ggaactttct 3013741 gccgatacgg ctgtcaagac caacaccatc agcaactttt gaaacgtctg cgccgactcg 3013801 ctcacaaatg tttgcgatat cgttgataaa ggaaatcttt gtcgccagaa atgcattcgc 3013861 ggcgtattta atcatttctg cactttctag gtttgtttta atgacaggag catggaatgg 3013921 ctgatgaagt tcctcaatga tggcagcggc tttatgactt gttgaaccaa tcacggcacg 3013981 ctccatattc atcgtgtcat gaatcgctga cccttcccga aggaattcag ggttagatac 3014041 aacatcaaat gagtatctcc cctttgaggc tttttgaacg atagattgca ccagtttccc 3014101 tgttccaacc gggactgtgc ttttatttac gatcactttg tagccgttaa gatgctcacc 3014161 gattgttttc gccgccgctt tgacgtacgt taaatcagct tcacctgttt tggacatagg 3014221 cgttccgact gcaatataaa taatatctga ggcccgaatg gcagacggga tatcgttcgt 3014281 aaaggtcagg cgctgatcca gcacattttt ttcaactaag tctgcaagcc ctggttcata 3014341 gattgggatt accccatttt tcaggcttct gatttttgat tcatcgatat cacagcaaac 3014401 aactttattg ccgatctccg caaagcaagt gcctgatacg agtcctacat aacctgttcc 3014461 aatgacagct atttttttca cagcgctcaa ccctctcctg taaaatgatc ttccaattta 3014521 taatggtcgc agtgtcttac gattaaacgg acgttttcgt gaccgtctga tactgatgat 3014581 gcaaggcctt ggcgtttttt cctgcgtcaa attgagcctg cacggtttca tacaagtcat 3014641 ctgctacttc cggcttccat atttgctcat gttcgtaccg agtgatcgct tccgccaagg 3014701 cttgagcgga tttcggttta atcagcagat gttggtgctt tccgaataaa gacgacactc 3014761 cgccaacatc cgtacaaata acaggaaccc ttagcgccag cgcctcaatc acaacagtcg 3014821 gcatcccctc actgtaagaa ggaagtacga atagatctgc cgcaagtaaa tagtctctta 3014881 cctgatgatt cgggacttgg cctgtgacga tatgcccctt ctgcgtcagc gtcgattttg 3014941 cgggaccatc cccgacaaag actgccttag gagagtcctg cagcgattcg atcgcttcag 3015001 acagttcaaa aatgcctttc tctctgacca gccggccgac atagacagcc agacgctgat 3015061 cgagcgggag tccgagtctt tttctgattt cctctttcgt ctcctcattc ccctgaaaac 3015121 ggctgagctg tatgccgatt ggcaaaaccg agctgtcaaa gcccgaaagc tttttggctt 3015181 cttcctgaag cttgtggctg actgctaaaa caactgacgc agaacctacg gcacgcttga 3015241 aggctttaaa cgcacctttg ctgtaatgcg gatagacatt cacatcactg ccatgcaagg 3015301 tcaggacata aggaatttgc gctgactctg acacgactgc cgcagccccg cccgatggca 3015361 tggcaaaatg cgcatggatc agatccggat ataggtcgcg ctgtttcatt gtttttaaaa 3015421 cggctgatgc gattctccga tgaggctgcg cccacttcag ctggccggga actgcccgat 3015481 agaaaggccg gtaaaccggt atcccctttc taatctcata ctccggtctg acatcctttt 3015541 ttcgatatgt ctttttcagc atgcggacag gtgctgaatg aaaaggccgt gggcatatca 3015601 cagtgatatc aagcccgagt ttttgcagct cttgcacctg tgtctcatga aacacaccct 3015661 ctccgggttt catactgctc ggatatacgc ttgtgatcca caaaatcttc atgacaaacg 3015721 tccttttctt agtagtttgc ttttcgtttg agggtacgct tttaccaaaa gaaagagata 3015781 gcacagcgcc ccagccgcaa ctgaaatggc cagccgcatt tctgcctgca tactgaagtg 3015841 ttcggtactg aggcttacac caaacgcgat gatgcccatc gccgcagtaa tcagaaatgg 3015901 cttcataatc gactggaaat aagctgaaag gttaagcttg atgacatatg ccaaaagcca 3015961 gcgcccaatc aggaaattaa caacgctgat aatggcatac acccatgcga ctgtcagcag 3016021 gcttcccgtc tgtacagctg caaacagtga taatccgtac agcagcagca cgccggaatc 3016081 ccaataaaac gctaagtcag ctcttccttt agccagcaac acagatccat ttggattcat 3016141 gagcactctt agtattccga caatcgcaag aacatttagg atcggaacag cagcaagcca 3016201 tttttctccg aaaaccgctg tgataaaggc gtctgacaca gacacgagcc cgattaacag 3016261 cggaaacgaa acaagcgcca gcatttttgt catattcaga aagccttctc tgatcacgct 3016321 gttttcatat ttgttttttg cgaaaatagg gaatgccacc cgtgtgacaa tcggattgat 3016381 cttcaaaacc ggaatggtga caatctgata agcgaggtta taaatcccca atgcttcagc 3016441 accaataaac cggccgatca aaatcatgtc gatatttgct cccagcctgt tcacaagacg 3016501 ggatgaaagc tgaaaggctc caaaagaaaa gaaatccttc atgcctctca aatcaaaaac 3016561 aaaagcagga tgccactttt ttcggtatac agcccaatat aaaatccctt tactggactg 3016621 cagcaggact tgagaaatca cgtacgccaa aatcgcatcc atcataaaaa ccgctatcgc 3016681 taaatatccg aatgacaata catttgaaaa aatctctatt ttgcttaacg tattaaaatg 3016741 cagctgcttt tgcagcatat actgatattg ctgtccaatt ggcgcgatca aaaacataat 3016801 cgccagaatc cgaaccagaa acaccagctc ttctctttga taaaatcccg caatgacagg 3016861 actgctcaca tataaaagaa caaacagcaa aacgcccgtc ataatgttaa gccaatacaa 3016921 tgttgacagc tggcgctccg tcgcgtcgtc tctctgaatt aatgctgcgc caaaacccat 3016981 atcgagcaca atctgggcga aaactgtaac cgttgtgatc atgccgacaa gcccaaattc 3017041 tgttaaggtc atcatatttc caagcagggc aaactgaaca atttgtatga ttgtaataca 3017101 catggttgaa atacttgtcc actttgcacc gctcatgatt tgttttgtaa tacttggcat 3017161 catattccct acttcttttt aagctcagat tgatggtgaa taatggaatc ccgttttatc 3017221 ttgcaccatc acccgtccaa actactttac aagtttttaa cataattttt aattctaaag 3017281 tgaaagtcag attgcgaatg taatataaat caaatatcag cttttccttc ggcgtcatat 3017341 cgtaaccgcc gttcacctga gcccagacgc tgtgtaaagc ctggaatctc attctggaat 3017401 ttttccgtaa atacgggccg ttccggacga gggccaatca tactcatatc gcctttcagc 3017461 acattaaaca gctgaggaag ctcgtcaatt ctcgttcttc tgataaaagc tccgatcctt 3017521 gtcacccgcg gatcttgctt ctgtgcccaa accgccccag acttctcggc atctattttc 3017581 atggaacgaa gcttataaag cttaaatggc ttcccgcctt tccctacgcg ttcctgcgta 3017641 taaatggcag gccccggcgt ctccaaacaa atcaaaattg aaaataccgc aatcattggc 3017701 agcgcaatcg ccaatccaat gagcgcaaac caaatatcca ttacgcgctt tattgccaaa 3017761 taacgagccg tcttttcaga taatgtaaaa gaatgtattt gttgaactga gaattcacga 3017821 ctcacattca tgcttttctc tgcactcact gacacacacc tcacgatttg tttgggatgt 3017881 tatgatgacc tatgccagtc agtttagcag acggatgtta attggatgta aatggtatgt 3017941 taagaagtgt gaattacgtg ttttttctga taaatgttgt taatactctt ttactatttt 3018001 atatacaagt cctatttgtt ttaatcattt catataaaaa agagacaaat ctgtgattag 3018061 atttgtctct ttcgattatc tgtaataaga tactgtgccg tcatgaatag cttgtgcagc 3018121 tttatcttta taaaccgctt gcttcaattt acttgcatct gatgcattag tgataaaggc 3018181 agtttcaact aaaacactcg gcattttaga atatttaata acatagaaag cagctgtttt 3018241 tactccccgg tctctcgttc caagattagc cgctaacttt ggttgaattt gttcagccag 3018301 tctcttgcta tttgcagctt gatatgttgt atcgtagtac gtctcacttc catttggtga 3018361 tgagctatca ttagcatttg catgtatact gagaaataaa tctgcttgtg cagaagctgc 3018421 tttatttact ctctcctgta aagaataaaa agtatcatta gatcttgaca gtactggaag 3018481 agcacctgaa gcatttagct ttgtattgac tcttttcgct atatcaaggt tgacttcttt 3018541 ctcaaggagt ccattgccga ttgctcctga atcttgatca ccgtgacccg gatcaataaa 3018601 gattgtttca cctacaactg gattctttag ctgattagca acctttgtgc ttacggcagg 3018661 agtgtttccg ataatcataa agtttgacat gtttttactt ccaataattt tacgggctcc 3018721 tgtagataaa ttttcaccat ttgtaagaat aagagattgc ttcttcttag ctgccagtgt 3018781 agctcctgca atagagtcag ggtagctgaa tccattgctt acatatacgg tgcttgttga 3018841 taaattaagt ttttgtacga tatttgcagc aagctcatat ctgtttgaac cgctaattct 3018901 tgtaggagaa ggtaacttgt tgtataccgt attgctgata cttccagtgc ctcctacaac 3018961 aacggtactc gaaattccct tatcttttat cacagacgta gtcgcactat ttatagatgt 3019021 tttatttgta aaaagaattg gatacccgtt tttcgctgca taagggatga cggccggagc 3019081 gtctgcatat aagaagccgt tcaaaataac agcttttgaa gtcgcaccca tcgcttttgc 3019141 cacccgtgca gccgtatcat aacggttgct tcctgcaatt cgtttaatac ttatccccaa 3019201 gcttttaatc tggttagcag tgttagaaga aacagcaggt gttccgccta caataattac 3019261 atttttagtc tgcatctctt tcaatcttgt tttcgtttca tatgaaagct tatcagaatt 3019321 agtgtaaagc aatggcgcat tcttctggta agcaagaggt gctgctgaaa tagcatctgc 3019381 ataggaactc ccaccaacaa ttacagctgt acttgctgtt gaatacattt gctttgatat 3019441 ttgtacagca gtgccgtatc tattgcttcc cccaactctt ttcactgagt tatcggccaa 3019501 agctgttggc acaaaaagta tgagccccag aaaacacatt gttaggactt ttatataaga 3019561 acgcaattga tttcctcctt aaatggcgtt atatcctaaa ataatcaata acttgtcaga 3019621 gttgtacctg gatagtaaaa tttcaaaatt gaactatatg aatctccagc ttctgctctt 3019681 gcttttgctc catattgact cattccgatc ccgtgaccat atcctttacc gctgattgtg 3019741 tactttgaag tatctttttt tacagtcaca taagtacttt taaatacagt cgctccaatc 3019801 attgttctta actcacttgt tggtacacta atggttgtaa ttttgctcaa gttataggag 3019861 ccagtactgc ttttaacaaa atacttcact ttcatcgatg ctgtttttgc acgctgccct 3019921 tgtgtcgttc cactaaagct taaatcgtca atacttgcaa ttttgacaga atcagcgctt 3019981 gtttctttat ttttcaagat ccagttctta actccggaaa gtcttgcaga atcagtttca 3020041 gtcgctgaag accaccaaga agaaggcttc gttaagtcca aagatttcgt atctagctgt 3020101 tgttttgaca aagtaagcgt ccagcctatt tgaggatcct ttgtatcttt ttttgcaatc 3020161 aagtaaggta cacttgacga ccacacttca ttactagctt ctgtgtaacc accattactg 3020221 gaagaataag ctgcagttat aagagatcca ttatatttca gaactttccc cttcgtttgc 3020281 tctaccgctt tattggtatt cgaattccaa ctgtagccac cataaacttg aaaagcggtt 3020341 gtatcaggta cagtagttcc tgtttttgtt attgagtagg ttcttgcagc gacagtctgt 3020401 gctttaagag cctcaagtga ccagctagca ggcatttcat tcggaattac tccttttaag 3020461 taatcctcaa atggaatatt ctcatttacc ggtcggatat atttagtaga ctcaatagag 3020521 aaattaaccg tgccaagata ctgctttcca tcaagactaa ttctgtttga agtagaatag 3020581 ttttctggtt taattcttag ggagtttccg taagttttga tgttttcaag gtttaatttt 3020641 ccgctgttga tttttagatt ataggtgcca ccgtcagcta aataaaattc atcagcaagt 3020701 gaattctcaa cttcagcaga aattgaactg gtacttccaa taaagtcgta tgcatatgtg 3020761 gctttatctt tcgttatact tttagccgca gccggaacgc tatcttgttt aacaaataaa 3020821 atttggctgt ttttcttcga ggcaagcgaa gcgcctatca atacgtctgc atattttgtc 3020881 ccgttcgtca ttacgacttt atcagccttc aactttagtt gcttaattat atttgccgta 3020941 agttcatatc tggttgatcc aggaatcctt tgcacagttg aagttttttt aatttggttt 3021001 tctacactat cactgacgct aaatgaactg cctataatga tgacttgttt tggcaaatca 3021061 taatccggaa gcttgtcttt ctctgtaagc aaaatagggt atccgtgtgc tgctgcatat 3021121 ggagcaatgg ctaaagcgtc ttgaaatact cttccggtta caacgatcgc tttatcatag 3021181 ctgcccattt gctttgcaat attttctgat aagacatatc tattttttcc gcttatcctt 3021241 ttcacagcgc catatgattt cagcttgttt tctacgtctt ttgaaatgct tcgcgctccc 3021301 ccaatgatta aaatattatc agggttaaac ttagcaattt gtctttcagt agtttttgtt 3021361 aacgtgtcag gctgagtaaa taaaactggt gcgttcagtt ttttcgccaa tggaataaca 3021421 ggcaatgcat caataaaaat atctcggttc accaatatca ctgtattagg atttttccac 3021481 tggctgttgg atgcaagagt cgcagtttcg tatcgtgaag cgcctgcaaa acgatccgta 3021541 acagcaacat tatctccagt tactttataa aatcctgttg gcgatagact gatgctagat 3021601 ttatttccaa tataatttaa caatttaact gagatgtttg agtctgctgc aaaagaaact 3021661 gatggaatca ataataagat tgcagcaagt gaacacacta tcaattgttt gcaagatttc 3021721 aaaatttcag gttcctccct atatcttagt tggcacgttc aatatctttt aacagaagct 3021781 gaccctcatc atttttttca tatgtaatcg tgaccttatc tccactgtta aacttatcaa 3021841 gatcacttgt cgattcttca gtgatatcaa gactaaccgg ctcattatct actgttactt 3021901 ctattgtatg agtatcagct aaccctacat aagtaccttc ttttgtttca atgttactgt 3021961 ctggcgatac atcttcacct tgactctttt gactattaac cccgcaaccc gaaagaagca 3022021 atataaagaa cagtaaagca ataaattttt tcattttttt cacctcatta tattttatcg 3022081 tcaacctatt ttatatttta aagaaaaatt aagaaacaat gaaacttttt tttataaaaa 3022141 acgactattt taggatttca ttcttgtatt aaatagagtt gtatttattg gaaatttaac 3022201 tcataatgaa agtaatttaa cagacgaggt gcaaaggatg agaaacgaac gcagaaaaaa 3022261 gaaaaaaact ttattactga caattttaac gataatcgga cttcttgtac tcggaactgg 3022321 cggctatgca tactacttat ggcataaagc agcttcaacc gtggcaagta ttcatgaaag 3022381 cattgataaa tctaaaaaga gggataaaga ggtcagtatc aataaaaaag atcctttttc 3022441 cgtcttaatc atgggtgtgg atgaacgcga cggcgataag ggccgtgccg atacgctcat 3022501 ttatatgacc gttaacccaa aaacgaatac aaccgacatg gtcagcattc cgcgtgacac 3022561 gtatacaaaa attatcggaa aaggcacaat ggataaaatc aaccattcat acgctttcgg 3022621 cggcacacag atgacggtag acactgttga gaacttcctc gatgttccgg ttgattattt 3022681 tgtgaaagtg aacatggaaa gctttagaga cgttgttgat acacttggcg gcattacagt 3022741 taacagcaca ttcgcgttca gttatgacgg ttattcgttc ggcaaaggag aaatcacgct 3022801 gaacggaaaa gaagcgctcg cttatacccg gatgagaaaa gaagatccga gaggcgactt 3022861 cggacgccag gaccgccagc gccaagtcat ccaaggtatt attaataaag gcgctaatat 3022921 ttcttccatc acgaaattcg gagatatgtt taaagttgtt gaaaataatg tgaaaacgaa 3022981 cttgaccttc gataacatgt gggatatcca gtccgattac aaaggtgcgc ggaaacatat 3023041 taaacagcac gaactaaaag gtacaggcac gaaaatcaat ggaatttact actaccaagc 3023101 tgatgaaagc gccctttccg atattacaaa agagctgaag gaaagcctcg aaaagtaaaa 3023161 caaaaagaag cttcgcacaa tgtgcaaagc ttctttttta tttgcctgta aatgaatccg 3023221 gttgttcttt tcgatacccg taatgaaaca gcaattcttc cacaatccgg cgggaagcct 3023281 ctccatctcc atacggatta gaagcctggg acattttctt gtactcatca ggatcagtta 3023341 acagctgttt tgcaagctga taaatgtttt cctcatccgt acctgcaagt ttcagcgttc 3023401 ccgcttccac tccttcaggc cgttccgtcg tatcacgcag aacaagaacc ggtttcccga 3023461 gagatggggc ttcctcctgc acgccgcccg aatcggtcaa tataaaatgc gatttcgctg 3023521 caaagttatg gaaatcgatc acctctaaag gttcaatcag atgcactctg tcagaatcac 3023581 caaaatgctt atgagccgct tcccggacaa caggattcag gtgcacaggg taaacgactt 3023641 gtacatcttc aaattcccct acaattctgc ggatggcctt aaacatgttt tccattggct 3023701 cacccaaatt ttcccggcgg tgagcggtca agagaatcat tttatcctca cccacctgat 3023761 cgagaacagg atgtgagtaa ccatccctaa ccgttgtgtt gagtgcgtca atcgctgtat 3023821 tgcccgttac aaaaatagag tcggcctttt tgttttcttt taataaattg tctttcgcct 3023881 ggcctgtcgg agcaaaatgc aaatcagcaa tcgcccctgt catctgtcga ttgagctctt 3023941 ccggaaacgg ggaatactta ttccctgtac ggagccccgc ctccacatga ccgacagcaa 3024001 tttgatggta aaaagcggct aggcttccgg caaacgtcgt cgtcgtatca ccatggacaa 3024061 gcacaatatc gggtttgata tctttaaaca actcatccaa tcttacaagt gcgttagacg 3024121 taatctctgc cagtgtctgc cgctccttca taatgttcaa atcgaagtca ggcttgatgt 3024181 gaaacgcatc taacacctga tcgagcatct gtctgtgctg tgcagttacc gttacatagg 3024241 aatctatttc aggatatttt ttcaattcaa gcacaagcgg tgccatcttg atcgcttcag 3024301 gcctggtccc gaaaacggtc atcactttta gttttttcat atttgtcacc tggttttctg 3024361 ctatagtaaa taaattcata ctacatattc tacatgaaaa tgcatcattt taaatcattt 3024421 cattcttgat tcaaataaaa tgatataagt tttaatatta aggataaagc ttgtttaaaa 3024481 atggtttatc cgatatcata aaaatgtgta aaaacatatt gaaaagggta aatagagaat 3024541 agtttaacca taaatttttt cgatcataag gaaggtgcct tttaaatgaa aaaagtacgt 3024601 aaagccataa ttccagcagc aggcttagga acacgttttc ttccggctac gaaagcaatg 3024661 ccgaaagaaa tgcttcctat cgttgataaa cctaccattc aatacataat tgaagaagct 3024721 gttgaagccg gtattgaaga tattattatc gtaacaggaa aaagcaagcg tgcgattgag 3024781 gatcattttg attactctcc tgagcttgaa agaaacctag aagaaaaagg aaaaactgag 3024841 ctgcttgaaa aagtgaaaaa ggcttctaac ctggctgaca ttcactatat ccgccaaaaa 3024901 gaacctaaag gtctcggaca tgctgtctgg tgcgcacgca actttatcgg cgatgagccg 3024961 tttgcggtac tgcttggtga cgatattgtt caggctgaaa ctccagggtt gcgccaatta 3025021 atggatgaat atgaaaaaac actttcttct attatcggtg ttcagcaggt gcccgaagaa 3025081 gaaacacacc gctacggcat tattgacccg ctgacaagtg aaggccgccg ttatcaggtg 3025141 aaaaacttcg ttgaaaaacc gcctaaaggc acagcacctt ctaatcttgc catcttaggc 3025201 cgttacgtat tcacgcctga gatcttcatg tatttagaag agcagcaggt tggcgccggc 3025261 ggagaaattc agctcacaga cgccattcaa aagctgaatg aaattcaaag agtgtttgct 3025321 tacgattttg aaggcaagcg ttatgatgtt ggtgaaaagc tcggctttat cacaacaact 3025381 cttgaatttg cgatgcagga taaagagctt cgcgatcagc tcgttccatt tatggaaggt 3025441 ttactaaaca aagaagaaat ctaaacaaaa aggctattgg acattcatcc aatagccttt 3025501 ttttatttca acatcaaagt caatgtatgc tcttcattat caactgcgaa gacctgatca 3025561 acggcctgcc gcaaaaatta ataatcccag acaaacacac tgattgtaga gttaaacaaa 3025621 ctaaatgaaa acataaatac aaacatgcag attaaatagt aaatatcttg tattcaatgc 3025681 aagctaagta aacaccactt gctaaaagaa caatgactaa acaaccagca ttacaaaata 3025741 attaaataaa tttgaagcaa ttacaacaga aggcagtgaa ctgtcggaaa gttcattttg 3025801 gctaccatat taatcccttt aactacgctg ttggatttat caagaattgt cgggctaata 3025861 gaaaaccacg gaatcaaacc agccagcatt caaacgataa aaggcacttc tccgatacct 3025921 gttatgacca gcttactgtt gcgcatccca aatacaaacc agtacgccat cattagaata 3025981 aggggattta aaacctgcca taatacacca aaataattga ttttttggat ctttcggtta 3026041 aagaaattta aaagtaccag tgaatattgt aacaaatgtt gagttttttt cacttttaaa 3026101 aagtaaagag aagtctcgca gaacttctcc caacatttga agtgtcaata taaaacaaac 3026161 caacctcatt tagcaacttt attattatct aattccaaaa tagcattata aatacgattc 3026221 ctattatttt tatcagtata tgcaaaaaag ttatctactc tttttctata cttatcttcc 3026281 atacgactat tgtttttcat ataatagata actttatcca ctaagctatt atgattttct 3026341 aatacatcac caaaccccat ttttttataa tcataataat caagtttaaa atggtatgac 3026401 ttttcgtatt gataataaat aacaggtttt ttctcatatg caaaatcaaa cgcaacagat 3026461 gaaaaatcag taatcattat attagaagaa ttaaatagca tttgatagct gctgttatag 3026521 tcggcaaact ccacataatc atgcttttca aagtctacaa tctgttgctg aatatctggg 3026581 tgaggaaaaa aagttatttt ataattattt ttcttagcaa attcgattag ccgttcatca 3026641 ttaatcaaag cattatacct agaaaaatat tcactatctt taaatttcgg gttgtacggt 3026701 cttactcctt ttgcctgatc tttcggtaat acaatatctt ttctccaagt cggcattatt 3026761 agaagttgct tttctccctc actcttctta agattatcgt atctcggaaa tccacccaac 3026821 aaaatattct cttttttata gttgtaattc cctttcacaa tagaccgata ttcaggtttg 3026881 gcagaagtga ctaataattt gatattcttg ttgtatttgt ttaaccattc agaatgatct 3026941 gccattgtta ttccgtgctg taaaaagata aactcaaagt taaataaatc tctaaaataa 3027001 atctccatat taaaaaatgg atttacaacc catatatctg catgtgtcga tattactttg 3027061 gaagaggata aggttaaaat tttatgtcta aaagatctgt atggtatgac ctttccatat 3027121 tttttgattc tgtcgtaatc cttgctatct ttttttatta taaagtattt ttttacccca 3027181 tcattcttgt tgattgcata tttaaagagg tgctcggcat tatcatcagc tttgtcttgt 3027241 ctgtctatga ataaccatac tggttttcta ttaaaaatag tgaaaacatg gtgtaccatt 3027301 cttgccatca gtgccttctt aatcgctgat tttcgttttt ttgatttttc ccctgattta 3027361 tgtagggatt ttaagaaacg aaactctttt ataaatctat ttttaaaatt gttttttttg 3027421 aacattaatt ttttataatt ataataaaaa atataatctt ttttagccac ataagtatta 3027481 tataaatcgt ttgacaaacc tgaatacttg aaaaaacgaa gttttgtcaa cttccttttt 3027541 ttacccttag ttataaaaaa ctcaatatga tgattatctg ctagatgacc tttgggaata 3027601 tctattgaaa aaccgggata tttttttatt acttctccta aacttatata atcattatgc 3027661 tgtcttttta tattctttgc ttttattttt gtttcgccaa ttttagcata aaacttaaaa 3027721 cctttagaat taaacagcga gctccaaaag ccttctatgt gaatggaatc ctcattttct 3027781 tctaaaattt caatagttaa agtttgatcc gataatttcg aaacaatttt accttctctg 3027841 tataaataat aatcctgttc agtttctctt tcatatacat acctactata attttcaccg 3027901 tgctttattt ttaaagcatg atataaatag aaatggctga cactttttgt ttcaatgatg 3027961 acatcgtcgt caatatacga caatacttct cgaatcaatg ttaaaaattc actgtattca 3028021 ttttcgtcta aaggtgtttc actgatatcc ttaatcaata atttccactt caaatcatgc 3028081 ataaccatat attgaagaaa taaaggtatt ttctgttcat gattttttat aatatcgatt 3028141 aaattctttg agaaagtgat aagtgaatgg ttaaaccaat tcttatttgc tttagcagtc 3028201 tgcatggcag atgatccatc ttctctaact ctataatggt attttgcctc tttaaccaga 3028261 ccatactttt tcttttgcga tatgattaaa ttaactagtt tggcatcttc acctatttta 3028321 caattttcat caaacctgat atttttcaag gcatcttttt ttataaatgt agaacaacaa 3028381 tgagttaata tatgatgcgg ttctttttct acatccaaaa ttcttgtaga agaaaactta 3028441 ttatttagat tatgttctcc agttcttcct tctgcaaaaa aaatagggat tgctacaata 3028501 tcaatttcat tcttatgttc gtcaaagaag tttaaaacat tttcgaatgt tccttctgaa 3028561 actaaatcat ccggatccaa aaattgaata tatctacctt cagcatactt taaaccataa 3028621 tttcgagcac tgctcactcc gccattctgt ttctttgcat agacaatgtt attgggatat 3028681 ttctgagcat attctttaca aatgatttca cttttatcgg ggctatcatc attcaccagt 3028741 attaactgaa tattctcaaa accaatagtt tggttaatga tactttctat agcttcagtg 3028801 agatacaact caacattata aatcggcatt ataacactga aatcatagtt aaaacttttt 3028861 tcgttcataa aagattactc ctaacataat gtttatatga ataagaattc gggtaaataa 3028921 aattaagaaa caagagagta ctaatttttg caaaacaatt ttaatttagt aaaatgtatg 3028981 aaaagcattc cttacctttt tttaaaaacc cttgtaagca aacttttaaa aatgttcaca 3029041 tggttaagtt ctaaagaatc atttggtgtt tttagtacaa agtcaaatgc aaaggcccaa 3029101 atcggtattt cgacaacaaa accagcatat ctaaaatctc ttaatttata tccccatact 3029161 tcaattgttt ttttcagttc ttttcgtttg cattttttta atcttttaaa atattttata 3029221 tatattctgt cattttcttt catctcataa tactggttaa taaagtgccc tgttaattca 3029281 agtctaagcc cttttatttt tgccgaagta acagtacatg aactatgcag tactctttct 3029341 ttttttatat tttcaagagc ttctgtattt tcttttaata agtgaaacat aaattcttta 3029401 tagtacatcg gcatatcttg ttcttttata aattgcgggt caataaattt taaaacttta 3029461 ataaaatcat caacaaaaac tctttgttct tgttgatcta aaacagactt ataaacatct 3029521 ctatagttcg gatataaaaa cagttttata tgatatacaa ttaaaaattg caaataaggc 3029581 aaaactatat catatttgtt gaatgaatcc atcaacaaag tcatgtaaca ttcattcaac 3029641 aaatatgtgt accttttttt gttaaaccat gaacgatcaa ctaaagaatc ctgttctttc 3029701 cgttttctat aaaaatactt tccttctgca actgctccgt atcttttttc tttcagtaat 3029761 aactggttaa aaaagatagc gtcttcccaa aactttatag attcatcaaa aaggacggta 3029821 ctagttagtg tatgtcttct gtaaaaagtg ccgccaatat aaaaatgaat agctttataa 3029881 tcgttgagaa tatttataac tcttgttcct ttttcaaatc tattatttaa tttatgtccc 3029941 ccttcttttt cacctgtgta ataaacaggt aataccgcaa tatttacatg ttcggaatca 3030001 caaaaaaaat cataaacact ttgcagcgca ttttgagaga atgcatcgtc agaatcaaga 3030061 aaaccaataa atttagatct ttcgcttaca tttgataatc cacaatttct tgcagcagaa 3030121 ggtccagagt tttcaatttt catgatttta atattattag gatatagatt tttaaaggat 3030181 tcacaaattt gaggactgct gtcaacacta ccatcatcta ttaatatcag ttctatattt 3030241 tccttaaatc caattgactg gttaaggaca ctctctattg aatatcttaa ataattttca 3030301 gaattatata ttggtataat tatagaaaac atgtttgtac ctctttattt agaagttaaa 3030361 ggatcgtttc aattactctt ttagaagcct tgcctcttct aaattacaaa atttattata 3030421 aaaatcctca tagttatgat ctatataagg attatgtaac aactctttta ccgtatctat 3030481 aagttcttca cttgtttgaa gcaagtttcc tggcgttttt tgctgaaaat taaagtaaaa 3030541 acctctgata cagtctctat aagccgggag atcatacaca aaaaatacaa ggttttttta 3030601 aaaattcata ttatcaaaaa agacagaaga ataatccata atcaataaat cactaattaa 3030661 atataaatct cgaatatctt tatttaaaga aacatcgttc acaaaatatt tatatttccc 3030721 taattaaatt gttctgaaac tggataatac cattcttaca agaataacca tagagtctcc 3030781 aaggttccct cttcatttcc tctaatcaaa ttaaagttaa atttatactg gccagctttc 3030841 ttaaaattca ttatcccgca aagttggtgc atataaaatt atttttcttt aattccttat 3030901 ttgataatgt agaattggta ggggattgta gctaaactgt ttccagaata gctttcaaat 3030961 aaaattaatt tattgtttct tggcagaagg acaaaaattt taaacaaaac tgaataaact 3031021 ctaactagta aacttctgca attggttata ataaaaattt catcagtgaa ctccttaaag 3031081 agtgaagatt aatatttacg caaacaagaa aaaaagaagc aactgaattt acttcaagcc 3031141 tcttttagtt agtgcttcta taaactagcc atatcttttc tgatttgggt agttgaaatg 3031201 cctgctattc ttgtaaggta aatggcctca tagtattcct ttgtagacaa tcgtacgatt 3031261 aagtaatccc aggttctttt gctctttcca gtagcttcat atgtccatag tgaaataaat 3031321 caaacattcc gtacgtatca ctttcttcat tagataacat caccttccaa ccttttccaa 3031381 cttagaaaaa acaaaaatcc ttaactgatt gtttatcatt tcgacatatt ttttacgttc 3031441 cattaataat aaacaataat agcatatgtt cctataaaag ttaaggctct ttaaaaatgt 3031501 aaatcatcag cactttttga caatatcgtt gcattgatgt gtatttttta cagatctgat 3031561 atcttatcta tactcattac aacaagtttt ctattccgga agagtcaatt ctttttgtcg 3031621 cgttttcaag tgtaatgatt ttctttctgc tgcgtcattt attttgtacg ccctcctcat 3031681 attacttcat cgtcaaaacg tgaaggaatt gtaatacgta gttcctaaaa attttcgtgg 3031741 taaaatttag tgaagtcttt atcaggctaa gggactttat ctaaactacg aattacatat 3031801 ggagatatat agatgaaaag gagggttgat atgatataaa cgaaaatcaa ttagataaag 3031861 gaaaaactga acacttctga aaaaagtgat aagtttcttt cactatatcc tccaaaaaga 3031921 acctaaaggt cttggacatg ctgtctggtt cgcgcctaac tttatcggcg atgagccgtt 3031981 tgcgtttctg cttggagacg atattgttca ggctgacaca ccagggttgc gccaattaac 3032041 ggatgaatat gaaagaacac tttcttctat tatcggtgtt cagcaagtgc ctgaagatga 3032101 aacacactgt tatggcatca tcgccccgct gacaagtgaa ggccgccgtt atcaggtgaa 3032161 aaacttcatt gaaaaaccgc ctaaagacac agcaccttct aatcttgcca tcttaggccg 3032221 ttacgtattc acgcctgaga ttttcatgta tttagaggag cagcaggttg gcgccggcgg 3032281 agaaattcag cttacagacg ccattcaaaa actgaatgaa attcaaagag tgtttgctta 3032341 cgattttgaa ggcaagcgtt atgatgttgg tgaaaagctc ggcttcatca caacaactct 3032401 tgaatttgcg atgcaggata aagagcttcg cgatcagctc gttccattta tggaaggttt 3032461 actaaacaaa gaagaaatct aaacaaaaag gctattggac attcatccaa tagccttttt 3032521 ttatttcaac atcaaagtca gtgtatgctc ttcattatca actgcaaaaa cctgatcatc 3032581 tgtattcaca agaaaacgct tcttgctgct gtcatacaat acatcgctat cacttaagga 3032641 tagtgacgcc gggttgatag gagaaatgtt atgaaaaata agctctgttg ctttatcatt 3032701 ctccagtaca taactgattt tttcataatc aaaattcagc gtttttctgc cgtcagcctt 3032761 atttccttca gtataaccat tcaatttcga ttgaatgctg gtgctgctgt ctcctaggaa 3032821 tttcagaaag tattcatagg aagatgctgc gttttgcgag acataagacg taaatgcagt 3032881 ggcatgcaat tcagcgtgtt tcatgttagt tgcaacagcg ctctgtttca cataataaga 3032941 gtgcccgtca aactttattt tcgctgcttg tttgcctttt gcagctaccg ttacttttgt 3033001 accgaatggc agtgtaacgt cagccttctg tttcaaaccc tgatccttat aagcagccgc 3033061 tttttcattt gctataaacc cttgcttatt gattgcagtt aagcgttcct ctgacttgcc 3033121 ctttgcatcg ccatgatggt tcttcacttc attttgcgga atagcgccaa acgaagcaat 3033181 tgtacgaagc ggggcattaa agaacatcgt tcccgccatg aagacagtca gaatagacaa 3033241 aatagcaatt tgaatggcat tggccagtga tttcggcttt ttcttctttt tgcggaaacg 3033301 ggcaaacgct tcaggatctt ctttcttcct ctcttctgtc tgctcttttt tatatgtctc 3033361 tttttctttt ttcgatagct tattaaacca gtcaataaac gctttgtact ctttcacaac 3033421 cgtttttgtt tcatcaaaca tacgaagctc gccatagtgc atccaagcaa cacggtcaca 3033481 catcttttca atctgaccga ttgagtggct gacaaagaaa atcgtttttc cttgcttttt 3033541 aaactcattt attctgtcta cacacttctg ataaaacgtt tggtccccca cagaaagagc 3033601 ttcgtcaata attaaaatgt caggatcaat atgcacggag atcgcgaaac cgagacgcga 3033661 cttcatcccg ctggaatagt ttttaaccgg ctgattaata aaatcgccaa tctcggcaaa 3033721 ttcaacgatg ctgtcataca tatcatcaat ttctttattg gttaacccca tcatcaaaca 3033781 cttgagccgg acattgtccc ggcccgttaa ttggttattc aaaccggcag caatcgcaat 3033841 cagcgacggc tggccgttca tttcaatttc accgctggtc ggcggaataa ttttagccag 3033901 caggttagac atggtcgatt ttcctgaccc gtttattcct acaaagccga ttgtctcccc 3033961 ttcatacacg tcaaaggaga cattccgcac agcaaaaaaa ccattatcct tagccggaaa 3034021 aaacaatcct ttaatcttgt ccgattgttt tttatacaaa tgatactgct ttgaaacatt 3034081 tcgaaacgaa acttttagtt tcatcgtaaa atctccttac gtattaaaga aagtcaacaa 3034141 acttgtctct gaatttcata tgcaggatag aacctactaa caataaaagg aatgtgaaca 3034201 accaaaagta cagcgtgtac ttcatgtcat ggaaaaacca tgctccatct aagaagctgt 3034261 tccggaatcc ttcaataata tagaatagtg gattcaactt cagaacaggc actaattcgg 3034321 ggtggctttg accgagtttc gcattaacat cccaaaaaat tggcaacaag aaaaacaaaa 3034381 gtcttgttac ggcctgcagc aaaaattgat aatctctaat cagcacactg atcgttgagt 3034441 taaacaaact aaacgaaaac ataaaagcaa tcatacagat gaagtaataa atatattgta 3034501 accaatgcac actcgggaac acaccattaa ctaggagtac aatgatataa atcaccatca 3034561 tgatcatata actaaataag ttagatgcaa ttgccacgga cggtagagaa ctaatcggga 3034621 agttcatttt agccaccata ttaatgcgct taaatacact atttgatcca tcaagtatag 3034681 ttggactgat gaaaaaccat gggattaatc ctgccagcat ccaaataata aaaggcactt 3034741 cgcccgctcc ggttgtcaca ggaccgccct ttctaatccc cataccaaat acgaaccagt 3034801 aggccagcat ttggataagc ggatttaaga actgccataa gacacctaaa taattcattt 3034861 gatatttaga cttggtttca taagccgcca atcttaaaat taaaggaaat gacgttattt 3034921 gctctctgag tatacgcaac aaatcattca ttttttatct tccttagact taattgtttt 3034981 tgggaatctt tctgtttaaa atttgaaagc accgctgatt attgtaacag atcctgcatt 3035041 ttttttcact tctcaacaag tatctaaaaa gctgccgaaa aatcgacagc tatacatttt 3035101 ataaaataac ctaaattatt cagctttaaa tacagtatta acaacctttt cagatgaacg 3035161 tcctgactct aaatagcaaa acttatcata gaaaggacca aaagaaaccg gaagcttata 3035221 atcaggcgat gagatctgct tgatagcctc aatcgtttct tcagtagttt ttaccaaagg 3035281 accaggagct tctttttcaa aatcaaagta gaaaccacgc aacttgtccc ggtaggtttc 3035341 gatgtcaggg acaaagaata gcattggccg ttttaaattt gcaaaatcaa agaatactga 3035401 agaataatca gtaatcagca aatcagaaac catatacaat tctcgaatat cctcataagc 3035461 agaaaaatca tatgcaaatc cttcaaaagg acctaaatca aaattctcag ctaccagata 3035521 atgcattctt aagattacaa tatattcatt tccaagttct tgtctaagtt gatgcaaatc 3035581 taaatcgaga tcgaacttat aacgcccttt tgcatagaac tgatcatctc tccatgtagg 3035641 ggcatataaa ataacctttt tatcacgagg aatatttaac ctactcttta tcaatgatat 3035701 tgtttcctca ttattatcat tatgaagaaa atcatttcta ggatatccag attcaatcat 3035761 tgtcttgtta aactgaaacg cccgtgtaaa gatctcagtt gaataaccat ttggggaaat 3035821 caagtaatcc caattagaag cttccttgat aaaattcctt ttatattttt tggtgtttgt 3035881 accaggcata tggacttctt ccatatccat tgcaagtctt tttaaaggtg tgccatgcca 3035941 tgtttgtaaa tatgttgtat gactaggttt cggaatccat aatggaagcc ggctgttaac 3036001 aacccaatac tcagctcttg ccatagcgaa gagccatttt aatgagaggc gattaatgta 3036061 aggaattccc ttttcatcaa aaggcgctga atattgttta tttacactcc aatacatttt 3036121 atactcaggg tggttttccc gcatatattc gtaaatcgct ctcggattac aactgtattg 3036181 tttcccatta aaactttcaa aaatgactgt tttcctttta actggcattc tgctagccat 3036241 catgaataga gatttgtatg ttttagtgat taacttgttt ctcatttttg tgatcttttt 3036301 tatttttgat actaatctct tcttctttcc tttaataaag tatttcatcc ttgttttcag 3036361 gctatagtcg tttactctga tacctagagt ctgctttttc tttttcttaa agacttcata 3036421 acgaactggt gcgttgtttg ttttaataat acttactaat ccttttaatt tgttttttcg 3036481 atctcctaaa acaagagcag tgctgttgaa ctgaatatcc gttccttcat cgtcattgca 3036541 tatatactcc ataaaaagac gataaacata acgtttttca tttgagaaag gaatttcttt 3036601 caaaggcact ttcacttcaa aatcatacag ttccggaaca aaaccatctg ctctcatgtt 3036661 ttccaggcca tgtgtttttc tttctagctt gattggaaat ttttcctcaa taggtgtttc 3036721 tccacccttt tttaaaataa ggttcaagtt ttttatccga tattgatttt cggaactcag 3036781 gtaccccgca taacctgtta tgcttatttc ttcagagcta atctcgattt gatcaaatct 3036841 gatgattttg gcctctcttt tcaccttaat agaaaagttg cctttatcag ttgtataagg 3036901 taaaatcaaa agttctgtgg tttgatcgac atgaaaggcg cgctcaattg aatttacttc 3036961 agcagaaaga cgcttcaaga gtggttcctg ctccgcatct tcatattttt ttcgaaattc 3037021 gacataaaaa tcatatgttt gtcccatttc aacaggcata ggcaaaacat gagcatttat 3037081 ctcagtttta tactctaatg agccagtgtt ttgaagcgga aattcagatt ccgttcctga 3037141 acgtctctct ttcagcttta aaaataactg gtaatcctct aaaaattggt gttctgaatc 3037201 aattgagatt aacaattcaa gacttcctaa attgtttttc aagcttttca aaatacattt 3037261 aatcacagtg ttttcaatca ttactttttt ctgctcctct gtataaaagc tctttccttt 3037321 ttgcttcctt ttattagtgt caactactaa ggacattaac tctcttttat ttccgtgacc 3037381 ctccaagaga aattgccttt aactgttgta tagggctcta ctctatagcc attattagta 3037441 tctatactgt ttcctgacaa ttttgtttct tcactcgaaa gtcttcgcat tgttttaata 3037501 tggccatttg cattgaaaac aatataaaaa tcaataactt gggttttatt agcagctatc 3037561 ttttcaatat ttacatcttt ttcgagatca attacaaaca gttgatcatt ttgtaagttt 3037621 gttgaaataa tttcagcctt attctttctg tccaagccca ctaaacgtat ttttttaata 3037681 tcattatgat caaaattctc aatgtcaatt tctattttag ttttatcaaa atcctcagta 3037741 taggaactaa tagaaggatc tttttttcca acctttttag agaacttctc tctttctatt 3037801 cgcacctcaa tcatctgatt aagagcaaaa gcccaatttt caatatagtt gggtcttgaa 3037861 tatttttcag ccattttaaa agcttgttct gaaaattttt gatgagtact ttcatctttc 3037921 atcaaagaga taatagcttg acccaatttc tctatattat actgttcaat gacatatcca 3037981 tttgctccgt cagtaactaa gctccttgct ccgtaatcat aatcgtatgt tacaactgga 3038041 catccattgc tcagtgcctc catatttgat agaccgaacc cttcaaaatg agaggttgaa 3038101 atggttagcc aagctttttg aaactctgag tcagggttat ccgtatagcc tttcaaaaag 3038161 acattgttct gcagtttggt atcttcaatt tcttttttta ttttttcgaa atcttcaccc 3038221 gatccgaata tatcaagttt tgcttcagga atttctttca cgactaaact aaatgctttt 3038281 actgcatgta tcagattttt catagatgca agtcttgaaa taatgacagc tttgtatttt 3038341 tcactcggca cattcaatac agcgggatca agaggcttat caattgtatg cggagtaaag 3038401 aaaaacgtct cttgttcccc tgaaatcaat ttaaaatctt ctagctgctc ctcagttata 3038461 aaaaagacag catccaaatt atacatctga ctaaatactt ctttatagcg acccttaatt 3038521 tgatatttat tgctgccgta atgcttgtta tgaataattg ctccataata ggaagaaggt 3038581 gattttttca ctttaaagac atgtttgtct tgcggtctgc tgtccactaa aaacaactta 3038641 ggtttatcat tttgtttttg cagatattct atccaatatt gacgcagttc cgattcatct 3038701 tttactttta tctcaccctc aagggagtac caaataatat gagataattg aacatctttt 3038761 tcttcattgt tccatacata gagtttgtct aaatatactt gattttggtc attaatatat 3038821 tcctgcagat acatcttgtt tagctgcaca tcataatgag taacgagaac taagtttccg 3038881 ttcttcgtat attcctctct ctttatgagc tggtttttat cattccaata gtcgacgtac 3038941 cggatagttt ctccatctcc gtagtaaact acagacattt cattgttctt cttaccaaac 3039001 aatctcaaca gagtttttgc aaatttcccc attccaactt gcttttttat ctggtcaagg 3039061 cctatccttt cttcgtatga tcttttccca tttgttctaa cacttaaaaa atcatcgaat 3039121 agattaataa cacttgtgaa ttttttatca atcttaccgt tgctgtacaa ttcatcaatt 3039181 tttgaagaca actctaaatc aaaacgaaac gttaagaaaa aggtgttttg gttacactct 3039241 tctccaaata attttgaacg caataataat gatttcgtca gaccgccata attacttggc 3039301 agtccaccag agataaaata ataatccatg tcaggaattt gttttatatt agattcactc 3039361 accgcatgta aagacaattt tttactccct ttcggcatct agaatatatg atcattgaaa 3039421 tttatatcta cccggatact ttagtcacaa aaatcaatgt aagcatcaaa aagtacttct 3039481 tatttcaata agaagtactt taattagata ttgaaccaat gatatcagga tcctaaatta 3039541 taaaccagca atttcctctt tgatctttgt tgtagagatg ccttctgttc ttgggaggta 3039601 aacaacctca cactgatctt tgagaaagtc aaatttacct tcccagtcat cccccataac 3039661 aaaaacatca atattatgat caataatatc ttgctttttt tgctcccaat tcttttcagg 3039721 aattacttcg tccacatatc gaatggtttc taaaattaat ttacggtgct catagctgtg 3039781 ataagctttt ttttgctttt gtaaattgaa ttcatccgtt gaaatagcaa caactaaata 3039841 atcaccaagc tgctttgcac gctcaagcaa tttaatgtga ccccaatgca gtaaatcaaa 3039901 agttccatat gtgataactt ttttcattta aagaaacgct ccttcctaat gttaaacact 3039961 attaaaaaca ctactgacgt tagcgattaa attctaaaaa cctgtttgta ttccttatat 3040021 cgacatattt ctcgtatgtc ttcactgatc attaattata gcataccgcc taaaaaaggt 3040081 taagtactca tgaggagaaa aacattccaa aatatgtaat tacactcaga ctccattggc 3040141 accaaggtct gttgttcatt cgttcattca attgtaaaat tggaaacata tttaaattta 3040201 atgtaaagat aatgttaatc ctttgttgaa gatttatgtt aaaatataag gtagcttgat 3040261 tttgctttta gaaactctcg gtttttaact atataaatag aatcttaaag gaaggaggag 3040321 ccagacatgc aaacagagac tattcacaat attccttatg ttaacagtaa cttaacatca 3040381 tttatcgatt acctagagaa acattatatt gatcaaaaga ttggtgctgt catttccaca 3040441 gtcaaccctg aaattgcatt tgcagctatt aaagatcggg actactttga tgtactatct 3040501 tcttcaaact tcattttgcc tgatgggatc ggtgtagtca tgatgtcacg tttgactaac 3040561 aacaggcttc agtcccgaat cgcaggttac gatgttttta aagaacttct gggcgttgct 3040621 aacaaaaaga aaaaacgcat atttctgtac ggtgcgaaga aagatgttat aaaaggtgtt 3040681 gtatccaaaa tttcttctga atacccaaac attaaaatcg caggttattc agacggttat 3040741 gttcaagatc gcaccctagt ggcaaaacaa attgcaagag caaatcctga catggtattc 3040801 gtagctttag ggtatcctca tcaagagaaa ttcattcata actacagaca cttgttccct 3040861 aaagccgtat ctataggtct aggaggaagc tttgatgtat ttagcggtaa tgtcaaacgg 3040921 gccccttcct ggatgatacg tttaaattta gaatggttct accggttaat cttgaatcca 3040981 tggcgatgga aaagaatgct tagcatccca aaatatgctt taacggtttt aaaagaagaa 3041041 aaaaacaaaa aaactttcta tccaaagcct gaaaaagatc atacaaaaca gatttaaaaa 3041101 caaaactttc aaataaatgg atgataaaaa tgaaaataag atcactactg gcgaattgct 3041161 atttgtattt tttatcagca atcgcctttt ttctgcaatg ggtgaaacct gaaagcaaag 3041221 tgaccctcct gatctcattc gaagcaaacg caaaagcgat tcttgaggaa tatgaacaag 3041281 gacaatactc ttataaactt aacatcctgt atacccagca ggcctctgct attgccgaga 3041341 gcttcccgaa tgtagatgca tatttattac aagaaaaaaa ccctatccat ctcattaaag 3041401 ctgtatacct aatgtttaac agtaaagtga tcataacaga taattacttt ctattaacaa 3041461 gtgtgttaaa taagcggaag caaacgaaat gtatccaagt atggcacgca aatggctcac 3041521 tcaaaaaatt tggtttggaa gacattacaa acatgcaacg gacgaaaact gatattaaaa 3041581 ggttccaaaa agtatacagt tcgtatgatt atttaactgt tggctcagaa gagatggcaa 3041641 atatcttcaa gaaatcattt ggaataaagg ataaccaatt attaaaaata ggtgtacctt 3041701 taacagaccc ttattaccga gaaaacaaga aaaaaatttc agatactcta aacatacaaa 3041761 gaaaaaaaat aatcctctat gcaccgacgt ttagagatta taatatgcaa tcaattcaat 3041821 tgccttttac agaagaacaa ttaattcatc agttaaaaga agaatatgtt ttatttgtta 3041881 agctgcatcc cgccattcag aacaatattg atattaaata ttccagtgat tatattaaag 3041941 atgtttctaa ctatgccttg tttgatctac tcatggctgc agacatatta atcactgact 3042001 attcttctgt tccctttgaa ttttcgattt taaataaacc cattcttttt tatacttacg 3042061 atttaaaact ttatcaacag aagcggggat tggttgataa ttatctttcc ataatacctg 3042121 gaagagcctg ctatgacagt gaatcattaa taaatgaaat tcaaacccca tttaattatt 3042181 ccaaaataaa agttttttcc gatagatgga ataagtattc tgatgggaat tcaagccaaa 3042241 atttattgaa tttcatcgaa aatttaataa gctaaatgat gacacttgtt caaaacagaa 3042301 caagtgttct tttttctatt gaataccgaa cgtatgtttg ctttaatgta attagttgct 3042361 tatggcagca aataataata gaggtggtaa atttatgaga aaaaaagaac tgtttgattt 3042421 caccaacatc acgccaaaat tatttactga actacgtgta gcagacaaaa ccgtacttca 3042481 atcattcaat ttcgatgaga aaaaccacca aatttataca acccaagtcg caagtggatt 3042541 aggaaaagac aacacccaaa gctatcgcat aactcgtcta tctcttgaag gtttacaatt 3042601 agacagcatg ctgttgaaac atggaggtca tggtacaaat attggaattg aaaaccgtaa 3042661 tggcaccatt tatatttggt ctctatacga taaaccaaac gaaacagata aaagtgaatt 3042721 agtttgtttc ccatataaag caggcgcgac tttagatgaa aattctaaag aacttcagcg 3042781 attctcgaat atgcctttcg atcatagggt tacacctgct cttgatatga agaatagaca 3042841 gttggcaatt agacaatacg atacaaaaaa taataataat aaacagtggg tgacaatctt 3042901 taacctggac gatgcaatag caaataaaaa caatcctctt tatactatta acattcctga 3042961 cgaacttcat tatttacaag gtttcttttt agatgacggt tatttatatt ggtatacagg 3043021 agatacaaac agcaaaagct atccgaatct cataactgta tttgattccg ataataaaat 3043081 agtgctgcaa aaagaaatta ctgttggcaa agacttgtcc accagatatg agaataactt 3043141 ccgtgaaccg gaagggatct gtatgtacac caatcctgaa actggggcaa aatcattaat 3043201 ggtgggaatt acaagtggaa aagaaggaaa tcgtataagc agaatttatg cataccattc 3043261 ttatgaaaac ttcatgaatc atgtacctat gcttcgatcc cctttattaa aaaccgtggg 3043321 gcaccaagat acacctccag aaagatttca accatttatt caaaccttca ttttagagta 3043381 taatgctcaa aacaaaaaat ggatggttcc gacttcaggt tatttaccat cttacacatc 3043441 aaatttagtc cgaaatatta ctatcaatgc agatggaaac ttgcaagtca cattaaatga 3043501 acgctatatt agtttactgc atcaatcgat agaaggagat ttccgcttaa aacaaaagga 3043561 tatccgaatg ggatcctggt attttgccgg cggagaaaaa tcaaatgtgc ttgaaatagg 3043621 ttttatgaaa gggagtacaa aaatcagacc cgatgatgca gccatctcaa atgcttcaag 3043681 aatgagtatt tttatgattg ttgcggacaa gattgaggtg tgataatcaa ataggctgta 3043741 gctatttaat agctacagcc tatttgcaac tttctaagtt ttttatcgat attccggaac 3043801 atcggcctac tttatagacc agcttctttc ggggcaatat gcataaagaa aagactccag 3043861 agattggagt ctttttcttt tattgcaccc gtatacttcc tgcgtattta tccttccaat 3043921 atgtgctcgt gttcatattg gtaatggtca cgccgtttga taatgtgaca tgaacaactt 3043981 gtccgtttcc gatatagatg gagggattta agcttgttga ttgaaagaac acaatgtctc 3044041 ccggcttcag gtccgccttc tcaatcttag ttccggcatt gtactggctt gttgcgtatc 3044101 gaggcaggga aataccggct gctttctggt atacatattg gacaaatcca gctgtatcaa 3044161 atcccgtctc aggtgttact ccgccctgtt tgtaaggcac ttctccgaca taaagcgtcg 3044221 cttcggaaac aatcggattt tctttcggga ttgtcaggtt gtcaaatcgg cgaatacccg 3044281 tcatcttcga tttccagtaa tcctctgaca aataggaaat ggttactttt tctgaccggc 3044341 ttgcctgaat gaacctgcct gcgcccgcat aaatgcctgc atgtgaaatt cccgttttat 3044401 acgtattgct gaaatagacg acatcaccag gctttatgtt ctgaggggct accttctcgc 3044461 ccactgccca ctgctgttcg gctgatcgcg gtagataaat gccgagtgcc tgttgaaaca 3044521 catattgcac aagccccgag caatcaaagc cctctgacgg cgtgcttccg ccaaacacat 3044581 atgggacacc gatatatttt tcggcctcct gaacgacagg aacatcagcc gttgccggat 3044641 cggcagcgat tcgtctcgcc ccgatataag ttccgctcca atagctgctt tttttgtaat 3044701 tggtgatgat aacccctttt gactgtgtac tgtgaaccat ttggccgtct ccgatataaa 3044761 gggcgtcatg tgtcggaaca gtgccggtgc ttccctcttt cttgaaaaac aaaatatcac 3044821 ccggcttcag gttttccggt tttacagctg ttccgatttt atactggtcg tttacagatc 3044881 tcggcagatg aatatcagcc ttactgaaca catattgtat caatcctgat ggatcgaaac 3044941 cctctttcgg cgtttccccg ccatatttat actgatatcc aagcaggttt tttgcttcgc 3045001 tgacaatcaa ttctgatgat gtatcagctt ccgcaatctc cgcttttgtc ataattggaa 3045061 ccaaaaaaca aatgataacc gccacaagca aaaacttctt ccagtttgcc agtgtgttca 3045121 cttttattat ctcctcctct ttttgcagtt ttaacatcgg tatttttttg aatatgttaa 3045181 gagacttttt aatattttta cagaatgaat atgctgggca aataaaaaga gagtgtctca 3045241 tcagacactc tcttttttga attatttatt ggcgtttacc ggttcttcct gctgctggat 3045301 tttattcatt tccatatcaa tcttctgttt ttcctgatct gtcagctgat cattgaattt 3045361 aaaagctgac ataaacatga acacgatggc tacggcaaca aacggccaga tggctttgac 3045421 aaatttcatc tttatcactc cgattattta gattttagtt tgtcactatg atcaatatca 3045481 aacgtcagtt ttccgtcttc tactttccaa gcgaaattag agtctttcgt cagttcgcga 3045541 ataatggttt tctgtttaag gctgtctttt ttcacaggcg caggtgtcgc ttcatggata 3045601 tcgatcggtg tcacttcaaa gcgtcctgtt ccatttttct tcaggtgata ctgaaccagt 3045661 gcactgtctc ttgttctcgt ccagccttgg tcaaagacaa agttgccgag gctgtagaaa 3045721 atgacggttc cgttatatac ttcaatcggt tctaagacgt gcgggtgatg gccgacgatg 3045781 atgtcagctc ccgcatcaga catggctctt gcaagctggc gctggcggtc atttggatca 3045841 ttgtcatact cttgtcccca gtgtgactgc acaacaacaa tgtccgcatg ttttttcgct 3045901 tctgaaatca tagggatgaa gatttcagga tctgcgggca gcacgcccgg cgtattcttt 3045961 ttagccgcga aacctttccc ggacacatcg gtaaagccaa gcgtcgcaat cgttaccccg 3046021 ttgactttct ggtacgaaat tttctttttc gcatcactta agctgtatcc cgctccaacg 3046081 atatcaagat tttgcttcgc aaattctcca agcgtatctt tcatgccctg aacgccgtaa 3046141 tccattgcgt ggttgttggc gctgttgaga accgtgaaat tcatatcctt caagactttc 3046201 actgattcct tattcgtctg cagatgaatc tctttatctg cttgtttata attcttttga 3046261 taggttaccg ggttttcaaa gtttcctgct acataatccg aggctctaaa gatcggttca 3046321 acatattgaa aaatactgtc tgcccctttt tgctccgtta ctttttcaac atagcgtccc 3046381 atcataatat cgcctacaaa tgaggctgag agtacgtcgt cagaatacgt tttgaccttc 3046441 ggcgtttccg cttttcccgc ccacatgaaa gcgaacataa ggacaaaaac gatcggaatg 3046501 gcaataaata cgtgcttatt ggttttcttt ttttgctgtt ttgtcagctt tagcagcttt 3046561 tcatgaaagc tcagttcttt tttcatcgtt tgacacacct tacattaaat taagtagtaa 3046621 acaaacatga tagcaaaggt cgctccgctc aatagcagcg tgcttccgaa cgtaatggtt 3046681 aaaccttgtt tctgaatggt attggcaatt aaacctggca cgatgatgcc gattcctcga 3046741 aattctgcga tttcaaatgg tacaatcggg tatagaaaat caaacgcgat ttttaggacg 3046801 atccctgtta tcagcatggc agcgaatttt ctgcgtccgt acaaaatcat aaatttggat 3046861 aaaccgtatt tcacaatgac atacgtgagc aagctcacta gcaaaacaag taaaataaag 3046921 accggctgat taaacacaag tcctaaatat cccggtacaa caagtcctgc cggcacgatc 3046981 cctgtttttt ccgcaaaaat taaactgagt agtacaccta aaattagtgc gatgtataaa 3047041 tctgatccga acatgtctgc atttccccct agcttacgag ctgctttacc ttgtattcgt 3047101 ggattttttc aattaaaggc tctgcggcac catgaatatt gccgacgcca tatatgacac 3047161 ggttgtgcat tcttttcttt aacaattcca taatttcatc tgttgactta tactctagat 3047221 catgcagttt gtctgcagga attttgcctt cttcgtaggc ttttacgatc ggttctgttg 3047281 tttcaccgat taagatcagt tcacttgctt caatataagg caatacgtca tttgcgaatt 3047341 gctgtgtccg atcgacacgg tctgcgcggc agttcatgat gatgatcgga tcatcggtcg 3047401 ggtaaccgat ttcttttaca cgtttccata tattcaaagt agaagaagcg tcgtttgcgg 3047461 caaacccatt aacaaagtgc ccaggctcgc tcggactgat cagcggaaga attctcattg 3047521 ctcccggatc tggcggcgca ttcagcattc ccttaaatgc tgtttcttcg tcaatgccga 3047581 gtgcttgagc cacacccagc gccagagaag cgttatcagg gaataccatg tattcaaatt 3047641 tacgtaaata ctcatctgta atttttgagt tatcagcaat gatgactttt gtgtttcgtt 3047701 cttttgcttt ttgtttaaag aactcggtat attcactatc tgtaatgaca agatggccat 3047761 tataaggaat tgtagcagta aacgcttctg caatttcatc aagcgtcggc cccatgacat 3047821 ccatatggtc ttccaaaaca ttcacaatga cgccgatatt ggcctgcaga agttcttcct 3047881 gaaagatgat ttgataatct gggttaacag ccatgcattc actgacaatc gcgttagccc 3047941 ctctttctac tgtttctctc atgacttctt tttgctctcc gatattcggc ccctgaggtt 3048001 tccgtttaat cggcttttcc tccggtgtgt cccagtaaat cattcttgca tctgttcctg 3048061 ttgtttttcc aacagtcttg taaccggctt ctattaatat tccggttgtc agccttgtca 3048121 cagtcgattt tccgcggatg ccgttaatat tcacccgaac agggagggca tcaatgtttt 3048181 tctgatgtcg tcgtttttct aatattccga tgaccagtat gacagcacag gctataatga 3048241 gtaaccacat tgcttttcga catctccttc tatattgttg taaattcatt catcagtata 3048301 tagaatcact atgaattctc aatcggcatt atgtaacata atcttcccta atcgactaag 3048361 ccaaacttct cttttgaaag agattttata cctacaaact gttttctatt tttggaaaac 3048421 agcaggactt ataccttatc actttttaaa aaaatcaaag agaatgcgct ttcatttttc 3048481 tcctgatatc cttctggacg tatagtcaca ccctgctgtt tgtatttaat atgcatttca 3048541 aatcaatctt tttttcagcc tttgttatca agcatttcct gctatcatgc gtgtttccgg 3048601 ttcttatgaa cacaaaataa ttttatcctg tttcttaagg acaaggtcat aatgtcatcc 3048661 tttctgcatg gaataagcaa tatgaggccc attccaaaat gactaaggag gttcgagatg 3048721 aaaacgctaa acatacgagt ccgaattctc taacataatt aaacattttc tgggatgata 3048781 gtcttttctg tttctcccca tttacaggtc taaacgcatg actttgaaac aattttaata 3048841 aaacttaata tttgttcaag aaatcttcat ccatatttgt gaagactttg tcaaaaaaag 3048901 agtgaaaacc ttaaattttt caattatata tacaatttac aattagattt cttttgatat 3048961 ttttattgct aacttcggat tgttcatgat aatctatcta tgtaaacggt tacataaaca 3049021 aggaggagct gttttggcta caattaaaga tgtcgccgga gcggcgggcg tttcagttgc 3049081 gacggtttcc cgcaacctga atgataacgg ctatgtacac gaagaaacgc gaacgcgtgt 3049141 catagcggcg atggcgaagc tgaactatta cccgaatgaa gtcgccagat ctctatataa 3049201 aagagaatcc cgactgatcg gacttttgct cccggatatc acaaaccctt tcttccccca 3049261 gcttgcccgc ggtgcggagg atgaattgaa ccgggaaggc tatcgcctta ttttcggcaa 3049321 cagtgacgag gaattgaaaa aagaacttga ataccttcaa acctttaagc aaaatcatgt 3049381 cgcaggcatt attgccgcaa cgaattaccc ggatctcgag gaatacagcg gcatgaatta 3049441 tccagttgtt tttctggaca gaacgcttga aggggctcct tctgtgtcca gtgacggcta 3049501 tacaggagta aagttagccg cccaggctat cattcacgga aaaagccagc gcattacgct 3049561 cttgagagga cccgctcacc tgccgaccgc tcaagaccga tttaacggcg ctttggaaat 3049621 cttaaagcag gctgaagttg attttcaggt cattgagaca gcttcatttt caattaaaga 3049681 tgcacaatcg atggcgaagg agctgtttgc ctcttatcca gcgacagatg gtgtgatcgc 3049741 gagtaatgat attcaagccg ctgccgtttt acatgaagca ttgcggcgcg gaaaaaacgt 3049801 gccggaggac attcaaatta tcggctatga tgacattccg caaagcggac ttctgttccc 3049861 gccactttct acaattaaac agcccgcata tgatatgggg aaagaagctg ccaaactgct 3049921 tttgggtatc attaaaaaac agccgctggc agaaacggca attcaaatgc ctgtcaccta 3049981 tataggaaga aagacgacaa gaaaggaaga ttaagatgcg taatatttgt gtgattggta 3050041 gctgttctat ggatttagtg gtcacctcgg acaaacgccc aaaagccggt gaaacggttc 3050101 ttggcacgtc atttcagact gtgccgggcg gcaaaggagc aaatcaggcc gttgccgcag 3050161 ccagacttgg ggcgcaagtg tttatggtcg gcaaagttgg agacgatcat tatggaacag 3050221 ctattttgaa taatctcaaa gctaacggcg ttcgcactga ttatatggaa ccggttacac 3050281 atacggaaag cggaaccgct catattgtgc ttgctgaagg cgacaacagc attgtcgttg 3050341 tcaaaggcgc gaacgatgac atcaccccag cgtatgcgtt aaacgcgctc gaacagattg 3050401 aaaaggtcga tatggtgctg attcagcagg aaatcccaga agaaacggtt gatgaggtgt 3050461 gcaaatactg ccattctcac gatatcccga tcatactaaa cccagcaccg gcccgcccgc 3050521 tcaagcagga aacaattgat cacgctacct atctgacgcc gaatgaacac gaggcttcga 3050581 ttttattccc tgagcttacc atttccgaag ctctggcgct ttatccggca aagctcttta 3050641 ttacggaagg aaaacaaggc gtccgctatt cggctggcag caaagaggtg ctcatcccgt 3050701 ccttccctgt agaacccgtt gatacaaccg gagccggtga tacgtttaac gcagcatttg 3050761 ccgtggccct ggctgaggga aaagacattg aagccgcatt gcggtttgcc aatcgtgccg 3050821 cttccctttc tgtctgctcc ttcggtgccc aaggcggaat gccgacaaga aatgaagtag 3050881 aggagctgct gtcatgaaaa aacacggtat actgaacagc catcttgcca agattttagc 3050941 cgaccttggc cacactgata aaattgtcat cgcggatgcc ggactgccgg ttcctgacgg 3051001 cgttttgaaa attgatcttt cactgaagcc gggccttccg gctttccaag atacagcggc 3051061 agtactggct gaggaaatgg cggtcgaaaa agtcattgct gcagctgaaa taaaagcatc 3051121 caatcaggag aatgcgaaat ttctagaaaa tcttttctct gaacaagaga ttgaatacct 3051181 ttctcacgag gagtttaagc tgctgacaaa agatgcaaag gcagtcataa gaacaggaga 3051241 attcacacca tatgccaact gcatcctgca ggcaggtgta cttttctaga aaggaagatg 3051301 aaacatgcag attgaaatga aagacattca taaaacattc ggaaaaaatc aggtgctgtc 3051361 aggcgtttcc tttcagctca tgcctggcga ggttcacgca ttaatgggag aaaacggcgc 3051421 cggcaagtcc acgcttatga acattttgac aggcctgcac aaagcagata aaggtcaaat 3051481 cagcataaac ggaaacgaaa cgtatttttc caatccgaaa gaagcggaac agcatggaat 3051541 agcctttatc catcaggaat tgaatatctg gccggaaatg accgttcttg agaatctatt 3051601 tatcggtaaa gagatatcct ccaagctggg cgttttacaa acaagaaaaa tgaaagcgct 3051661 agcaaaagag caatttgaca aactttccgt ctctctttct cttgatcaag aagccggcga 3051721 atgttccgtc ggacagcagc aaatgatcga aattgcaaaa gcgcttatga caaatgccga 3051781 ggtaatcatt atggatgaac cgaccgcagc gttgactgaa cgtgaaatca gcaagctctt 3051841 tgaggtcatt acagcgttaa aaaagaacgg cgtctccatt gtctatattt cgcatcgcat 3051901 ggaagaaatt tttgcgattt gcgacagaat taccatcatg cgtgacggaa aaacggtaga 3051961 tacaacaaac atctcagaaa ctgattttga tgaagtcgtc aaaaaaatgg tcggacggga 3052021 gctgactgaa cgatatccaa aacgcactcc ttctctcggt gacaaagtat tcgaggtgaa 3052081 aaatgcttcc gtaaaaggga gttttgagga cgtcagcttt tatgtgcgtt ccggtgagat 3052141 cgtcggtgtt tcaggattaa tgggagccgg ccggacagaa atgatgagag cgctgttcgg 3052201 cgttgacagg ctggacacgg gtgagatatg gatcgctggg aaaaaaacgg ctattaagaa 3052261 cccgcaggaa gccgtgaaaa aaggtctcgg ctttattaca gagaatcgca aggatgaagg 3052321 gctcctgctc gacacctcga tccgcgaaaa tattgccctg cccaatctgt ccagcttctc 3052381 accaaagggt ctcattgatc ataagcggga ggctgaattt gtcgatctgt taatcaagcg 3052441 cctcactatc aaaacagcat caccggaaac gcacgcacgc catttatcag gaggaaacca 3052501 gcaaaaagtg gtgatagcca agtggatcgg catcggaccg aaagtgctta tcttggatga 3052561 gccaaccaga ggtgtggatg ttggcgccaa acgagagatt tatacgctga tgaatgagct 3052621 gaccgaacgc ggtgtcgcta tcatcatggt gtcatcagag cttcctgaaa ttctgggaat 3052681 gagcgatcgg attatcgttg tccatgaagg cagaatcagc ggcgaaatcc atgcgcgaga 3052741 agcaacacaa gaacgaatta tgacacttgc cacgggaggg cggtaatatg aaaacggaac 3052801 aactgcaaac agaacaaaaa cggattcact tcgacggagt catgcaaaaa ctcggcccgt 3052861 ttcttggttt atttattctc gttatcattg tatctatttt aaatcccagc tttcttgaac 3052921 cgctgaatat tttaaacctg cttcgccagg tcgccattaa cggattaatc gcgttcggga 3052981 tgacctttgt tattttgaca ggcggcattg atctttctgt tggcgctatt cttgccctgt 3053041 ccagtgcttt agttgcgggg atgattgtgt ccggtgtcga tccggttctc gcgatcatcc 3053101 ttggctgtat cattggtgcc gtactaggca tgatcaacgg attattgatt actaaaggaa 3053161 aaatggcgcc ctttatcgcc acgcttgcga ccatgactgt gtttcgcgga ctgacgctag 3053221 tgtatacaga tggaaatccg attaccggac ttggcacaaa ctacggtttt cagatgttcg 3053281 gacgcggtta ctttttaggc attcctgtac cggcaattac gatggttctt gcctttgtca 3053341 tcctttgggt gcttcttcat aaaacaccat tcggacgccg aacgtacgct atcggcggca 3053401 acgaaaaagc cgcgctcatt tcaggcatca aagtgacgcg cgtgaaagtg atgatctatt 3053461 ctttagccgg gcttttatcc gctcttgcag gtgccatatt gacttcccgc ctgcattcgg 3053521 cccagccgac tgcgggagaa tcgtacgaac ttgatgctat cgcggcagtc gtcttaggag 3053581 ggacaagtct ttccggcggc cgaggacgca ttgtcggcac gttaatcggg gtgctgatca 3053641 tcggcacact taataacgga cttaatctgc ttggcgtctc atcattttat cagctggttg 3053701 tcaaagggat tgttatctta attgcggtat tgttagaccg caagaagtca gcttaggagg 3053761 gttttacatg aaaaaggctg tatccgtcat tttaacgtta tcattatttt tgttaaccgc 3053821 ctgttcgctt gagcctcccc aatgggcaaa gccatcaaac tcggggaaca aaaaggaatt 3053881 caccattggc ttgtccgtct caacgcttaa taatcctttt tttgtctcat taaaaaaggg 3053941 tatcgaaaaa gaagctaaaa aacggggaat gaaagtcatc attgttgatg cacaaaatga 3054001 ttcatcgaaa cagacgagtg acgtggaaga tttaattcag caaggtgttg atgcattatt 3054061 aatcaacccg actgattctt cggcgatctc aacggcagta gaatctgcaa acgcagtcgg 3054121 tgtgcccgtc gtaacaatcg atcgatctgc ggaacaagga aaagttgaaa ccctcgttgc 3054181 ttccgataat gtaaaaggcg gtgaaatggc cgcggcgttt attgccgaca aacttggaaa 3054241 aggagcaaag gtggcagagc ttgaaggcgt ccccggcgca tctgccacac gggaacgcgg 3054301 ctcaggattc cataacatcg cagaccaaaa gctccaagtt gtcacaaaac aatcagctga 3054361 ctttgaccgc acgaaaggcc tgactgtcat ggaaaacctg ctgcagggac atcctgatat 3054421 ccaagctgtt tttgctcaca acgatgaaat ggcgctcggt gctctcgagg caattaacag 3054481 ctcggggaaa gacatattgg tgatcggttt tgacggcaat aaagatgcgc tcgcttccat 3054541 taaagacaga aagctgtcag ccaccgtcgc tcagcagcct gaattaatcg gtaaattggc 3054601 tacagaagca gcagatgata ttttgcacgg gaaaaaagtg caaaaaacaa tatccgcgcc 3054661 tctcaaacta gaaacacaaa aataattgtc tgatgtttag gaacctgcga taacgtgaat 3054721 agagatatag aatgaattat ttctcttacg tgaggagagg aacggcatga acaaaccaac 3054781 aaaactattt tcaacattag cacttgcggc tggaatgact gcggcggctg ctggcggcgc 3054841 tggcacgatc catgctcaac agccagaaac aacggtaagc attgatgatt tatacagtta 3054901 tccgattgat tcttatttgg tatcagcaga ggctctaaat gtcagaacga agccttccgc 3054961 atcaagccag aaagccgata cgctgcactt aggagatagc ctaaagctga tttccttctc 3055021 aaatgctgac tgggcaaagg ttaagtataa aaatggaaaa acaggatttg tatccactca 3055081 ttacattgtt aaagcagcga caacggtaaa aaccaaaaca aaaacaaaag tgtatacatc 3055141 cgctgacgga aagagcatta agactcttcc agcagacaca agcgtttctt ttttaggctg 3055201 gagtaaaacg aataaaggcg gttttgattt tgattgggta ttcgttgatt acggcggtac 3055261 gacaggttat atgaaaacaa aggatttaca catgacaaaa taactgagag ggattccgca 3055321 taaatgcgga atccctttta ttatgaattg atttgtcaca ttcccaagat atttctcagg 3055381 aaatattgtc gtatgctgtg tcgaaacctt acatgatcat cgacattttt gttcacgcta 3055441 aaaagcggag gtgtaaatat ggatcaattt gaagcagcat atgaatcgta taaagcccgg 3055501 caaacaactg ccgatcaaga aaatgttcca tctggaaaag aagaaattat tgcggttaga 3055561 agaaatgagg aagacaatat tatcgcagtg aaaaccaata caggaagaga gctcgactac 3055621 cctactgcgc tgtcagaagc aaaatcagga aaactcgctc atgttgatgt cttccataaa 3055681 tacgggcgtg acattttgcg aagtgaaccg gacggcatca aggaaaataa cctgtctgag 3055741 ctgccggatt tttaaacaaa tacagccctg ccgtatgttg gacagggctg tattttaaac 3055801 aaaaggctgc tggatgtatt cggctaaccg ttttgcactg tgagaaatat cctctgcagc 3055861 tgcataattc acgccataga acacatatgg aggcagatac ttcatgccga tcagattact 3055921 cgtggcctga aatggtttca atagctcact gatcgagtaa tgatttgctc cgcccgcttg 3055981 atatttttcc gcttcgctcc ctgttgatac agccagcatc agctccttgc catgcaaggc 3056041 atttccttct gaaccaaaag cccagccata agtcagcaca agatcctgcc attttttcaa 3056101 gagcggcgga gagctgtacc aatatagcgg gaattgaaag acaatccgat cgtattcctc 3056161 gcacagctgc tgttccttcg caacatctat cgcttcatcc gggtattcct tataaagatc 3056221 ccgtactgtg atattgtcat gtttactcaa ttcctcagcc cacgccttat taacaactga 3056281 ggtctccata tgaggatgca ctgccaaaac caatattttc atcagaccac acctttactg 3056341 ttttgatgtt attttatcta aaatcaggaa aagagccaaa taaaaagaaa gccctgctaa 3056401 aaggggcttt ctttttttct tttattcagg gcttccttca gttgtttcga tatctttcgc 3056461 aaaatcaggg ttatccagat tcgcattaaa gaaatccgct gtgttcggaa gtctgagatt 3056521 catgttcatt ttttgagaaa tcgtaaccgt gcaatcctca agcacatagt caaaaacgtg 3056581 tccgcctgaa ttgcgtcctt cgtcaatgaa gtgcaggtga tagccagaaa cggcgattcc 3056641 gtttgcataa gctggtgtca agaaacctac aatcgttcct ctcacgttgt cgaagttgaa 3056701 aatcggctgt gttttgaccg cttcaaccat tggcacgtaa ggtttttctt gaagttctac 3056761 tgttcttgtc tgcacctttt taaacaatcc gtcaatgcga attgcataaa ataagtttct 3056821 gcttggcagc atgctgttga tctctttttc aaagtcttcg cgtgtcattt tcgcatcaat 3056881 tttgtgcgtc atgtccggtg taaagaacgt aaatgaacag aacggtgaac ggtctccatt 3056941 ttggaccggt gtcgcggttc cgtctgagcg aagacggtaa aattcgccgt caaacccaat 3057001 cagctctccg tcaagcttgt taaaggttcc gataccgaag tctccatatt tcggaatctc 3057061 tgacagttca aaatctccgt catatactcc gtctaataga gaagtcattg ttgatacttg 3057121 ataaatctgg ctcacaggct gatctttttg accacggctg agcacttgaa tgttgctttc 3057181 tcgtttcata tttcccttca ctccttttat ttagtgctgt tcataaaaca gtgtcgtgat 3057241 gcgcagagtg ctagagagct ttcgttttca tgagttcccc gaattctttc ggaagcttgt 3057301 cacttgctaa attaatgtta tcactgtagt caaccgggac atcgatgatg acaggacctt 3057361 cagcgttcat gccttgacgc agaacatctg ccagctggtc tggtgattct acgcgcaagc 3057421 cagttgctcc gaagctttcc gcatatttca cgatatcgat atttccgaaa tcgaccgcag 3057481 atgtacggtt atattttttc aattgctgga atgcaaccat gtcatatgtg ctgtcgttcc 3057541 atacaatgtg tacaattggt gcttttagtc gaactgctgt ctctaattcc attgctgaga 3057601 ataagaaacc gccgtcacca gagacagaaa ccactttttc tcccggtttc accaatgaag 3057661 cgccgattgc ccaaggaagc gcaacgccga gtgtttgcat accgttactg atcattaatg 3057721 ttaacggctc gtagctgcgg aaataacgtg acatccaaat ggcgtgcgaa ccgatatcgc 3057781 aagttactgt aacatgatca tcgactgcat tacgcaactc tttaacgatt tcaagagggt 3057841 gcgctctgtc tgatttccaa tctgcaggca cctgctcacc ttcatgcata tattgtttta 3057901 aatcagaaag gattttctgc tcacgctctg caaattccac tttcacagca tcgtgttcga 3057961 tatgattgat cgtggacgga atgtcaccga tcaattcaag atcaggctgg taagcatgat 3058021 caatgtcagc gataatctcg tctaaatgga taattgtccg gtctccattg atattccaga 3058081 atttcggatc atattcaatc gggtcatagc cgatcgtcag aacaacatct gcctgctcta 3058141 gcagtaaatc gccaggctgg ttgcggaaca aaccgatacg gccaaaatat tgatcctcta 3058201 aatctctaga aagggtaccg gcagcttgat atgtttcaac aaatggaagc tgaacctttt 3058261 tcaaaagctt gcgaaccgct ttaattgctt ccggtcttcc gcctttcatg ccgaccaaaa 3058321 cgacaggaag ttttgctgtt tggatttttg ctatggccgc actgattgca tcatctgctg 3058381 caggaccgag ttttggcgct gcaacagcac gcacgttttt cgtatttgtg acttcattca 3058441 caacatcttg cggaaagctc acaaaagcgg ccccagcctg ccctgctgac gctatcctaa 3058501 atgcatttgt aacagcttcc ggtatatttt ttacatcttg aacttctaca ctgtattttg 3058561 taatcggctg gaatagcgcc gcattatcca aagattgatg tgtccgtttt aaacgatctg 3058621 cacggatcac gtttccagca agcgcaacga cagggtctcc ttcagtgttc gctgtcagca 3058681 ggcctgttgc caagttagag gcacccggtc ctgatgtgac taacacgact cccggttttc 3058741 cagttaaacg gccgactgct tgggccatga atgctgcgtt ttgttcgtgc cgggcaacga 3058801 taatttcagg tcctttatct tgtaaagcgt caaataccgc atcaattttt gcacctggaa 3058861 tgccaaatac atgtgtgaca ccttgctcca ctaagcaatc aacaacaagc tccgcccctc 3058921 tgtttttcac aagggatttt tgttcttttg ttgcttttgt caacaccctc actccttatt 3058981 atgcatttta aacgtaaaat tttaaatatc ttgtgataag tttcactata cactctttgg 3059041 aaattgacct ccaatatcga ttcgccttat gattaatatg taatacgaat tattaaccta 3059101 tggaaaggaa tgcatattga atggagcttc gccatcttca atactttatc gcagtagccg 3059161 aagagcttca tttcggaaag gctgcccggc ggctgaacat gacgcagcct cctctcagcc 3059221 agcagatcaa acagctggag gaagaagtcg gagttacgct tctgaaaagg acaaaacgat 3059281 ttgtcgagct taccgcagca ggagaaatct ttttaaatca ttgccgcatg gcattgatgc 3059341 aaatcggaca aggaattgaa ctggcacagc ggacggcccg cggcgagcaa ggccttctcg 3059401 taatcggttt tgtcggatca gctacatatg aatttctgcc gccgattgtc cgggaatatc 3059461 gtaaaaaatt cccatctgtg aaaatagaac tgcgtgaaat atcctcgtct aggcagcagg 3059521 aggagctact aaagggcaac attgatattg gtatacttca tcctccctta cagcatacag 3059581 ctttacatat cgaaaccgcc caaagcagcc cttgtgtttt agctttgcct aagcaacacc 3059641 cattgacttc taaggaatca attacgattg aggatttaag agatgaacca attattactg 3059701 ttgctaaaga agcatggcct actctataca tggattttat tcagttctgt gaacaagcgg 3059761 gcttcagacc caacattgtc caggaagcca cagaatatca aatggtgatt ggtttagtca 3059821 gtgccggaat tggtatgaca tttgttcctt cctcggccaa aaaattattt aatttggatg 3059881 ttacttatcg aaaaatggac caaatacagc ttaatgcaga atgggttatc gcttaccgca 3059941 aagacaatca taatccgctt ataaagcatt ttattcatat ttcaaattgt cagcagacaa 3060001 gaactaaaga gagtgatgca ggtacatgaa caatacttgc aatctctttt ttcttttggg 3060061 attcttatgg aatttttatt aatttaatat aatcgcttag tacaacttta tatcagtata 3060121 cgtatacata cagtacaaat agttggcaag gacatcagta agcgcaggac attagtttga 3060181 ttttaaaaat gaaagataga gaggtgaagt aaattattga gttcaccggc atattcacat 3060241 tgctcgcttt tttcgtaaca atgattttta ttttctggag accaaaagga ctaaatgaag 3060301 ctatccccgc cacatttggc gctttaatgg ttttattgtg cggaagtgtg tcattggcag 3060361 acttagggga aatcggaaca aaagtcacgg gtgcatcggt tacaatcctt gccactatga 3060421 ttatggccat tgcactagaa agctttggtt tcttttattg ggtggctgca aaactgctcc 3060481 aacaatccaa gggttcaggc atcaagcttt tttggctaac caatttgctc tgctttctca 3060541 tgaccatttt ccttaataat gatgggagca ttttgatcac aactccaatc cttttgcttg 3060601 tactaaaata tttaggttta aaaaaacatc aaaaagcccc atatttatta agcggtgttt 3060661 taatagccac agcctctagc gcaccgattg gcgtaagtaa tattgttaat ttaatttctc 3060721 tcaaaatcat tggaatggat ctatatcttc acaccgccat gatgtttgtc cctagtatga 3060781 tgggactcat ttttatgact tgtctactgt ttatgttctt ttataaacgt cttcccaaaa 3060841 gcctgccaga tataccgggc cattttcagt ctctgcggca tagaaggtac catcctcttc 3060901 attcgccatc agctccttta ccagaacgaa atcaaacaaa aatcatgttg tttgtgcttg 3060961 catttgtttt tctcgtcaga atgagtctat ttgcagcatc atataccggt atttctgttc 3061021 ctctagtcgc tgtcatcgga tcttttatcc tgttgagctg gagatggatt tatttcaaaa 3061081 cctccccaag agacttgtta tataaatcgc cttggcacat ttttatattc gcttttacta 3061141 tgtatgtctt aatttatggt ctgcataata ttggattcac agagttactt gtgagttatt 3061201 ttgaacctgt ggtttctgga agcctcgccc atgcaacttt cgcatcaggt atctctactt 3061261 cagttttttc taatctcttt aacaaccatc cagcgttaat gatcagtact tttaccttaa 3061321 ctgaaatgac cctgaatcct tcaacaacaa aaatcatcta cttggcaaat attatcggca 3061381 gtgatatcgg ttcattatta ttacctatgg gaaccttagc aacgcttatt tggatgcata 3061441 tattaaaaca gcatgatgaa agtatttcat ggggcgaata tataaaaacg accattatca 3061501 tcattccgct gactgttctt tttacgttaa catgtttata tttttggatc agttggttat 3061561 ttctttagca cagtatgaaa cgaaaaactg ccttctgctt ttcaagaggg cagttttgta 3061621 tacactaggg aagatgcatt gtctttagat gatttaactt ccaaatgact ggctctccac 3061681 ttgcgttaat aagctcaatg atattattag agacaccctt taatagtccg actttttctg 3061741 gcacctctcc catatcaaat atgaccaatt caccaatatt ttttttgatc tgctcctcaa 3061801 aattacgcac aagaggaact ttggaaggca cgaccggcaa ttgtgagttg tcaagagtat 3061861 acggtgtttg ttcagttgaa taaggggtaa accattttaa atgatgcata gatataaaaa 3061921 gtattttaaa tacgggtgag aaaaatacaa tataatcgtt taaaacattt gtaacatatc 3061981 catggatcga tcgaccccca gttacataaa cttcaataaa ctggcctttg accttgttta 3062041 atgtatttct atatgaaaaa gcttgagttt ctgcctctat cattggatct tccggattga 3062101 tcaaaaatgg cttctcagta ctggtcacta ttttcgcctt gtttatttga tgaagatgca 3062161 acaagggaat ataaagataa ttgcagccat caaaaataac aaaaatatcc tgtccgatat 3062221 ctatgagggt gccgacaaac cttgtatctc ctgaaatgac aacctcaaca tctgtgttaa 3062281 ggaattgatt caaacctttc acgattctcc tcctttaact gaaaaagggc atcactttat 3062341 ctgatgctcc tccattatct attaaaattt acgtttccag tgatagtcta tcgttctgac 3062401 aatcgtttca tagctataat cttccttttg ttttcctgaa ctttttattg aacttgaata 3062461 gcctggtgat cttgatgatt gataatctga agatcttggt gatcgtttag atgattttga 3062521 tgattgataa tctgaagatt ttaatgatcg tttagatgat tttgaagaac tttttgaacg 3062581 tgacgaacgg ccagatttgg atgattgata atccgaagat tttagtgatc gtttagatga 3062641 ttttgaagaa ctttttgaac gtgacgaacg accagatttg gatgattgat catctgaaga 3062701 ttttagtgat cgtttagatg attttgatga gctatatgat tttgaagaaa tgaacgaatt 3062761 gctgtcctta tcattattgt cttcctggtt ttgttcattt ttttgatcct cttttttgta 3062821 cgaccctttt ggacctaagc tgatgctttt tatgtgaaaa ggatagatgc gaagcacctc 3062881 ttgatttttc actatagtat aatggccgtc ggcattatct acaaggatac cctcaatggc 3062941 ttccggacct ccacgattaa ttgaaaccca tttatgagtc agactcttaa aaacctcgct 3063001 taaatcatca gcttccaaaa ctccaactgg cgtctgctct tctattttca aatcaggctc 3063061 gtgtttactt atacttttga tgtgatggat attaaaatac actaccccat cctcatttgt 3063121 gtttaacgca gcgtaatcat ctcccagcca gaccaatctt ccttttttag attccggacc 3063181 cccttggtta aattgaactg attggtttat taaatgtccg attaagctat gaaaatcatc 3063241 agcatcgagc atttcctcag tctcaattgt tgtggtgcta ttattggtat cctcagtaat 3063301 acttttcaca tgctccaact gataataaat tatttttttt tcagcttgta aagctatata 3063361 atctgatttt acagctgtta attttccttt tttagattcc ggacctccac gatatacagt 3063421 aacaatttta tctttcattg agtgcaaaaa gttataatac gatatttcat tatttgaatg 3063481 atatttcatt ctcctcttgc tcattcaaat tcctcctagt cacttataca tagatgataa 3063541 acatactgca tatatacgtg tcacatttat ttgttgaact aattcaatag cctaattgtc 3063601 gctttttccg cgaataccca ttttcacgca ttcataaaat acttaaatga tctttgaggt 3063661 attgtgaacg gtttttaata tactcgcaga tcacatccgg ctcacggtca aaacgctcaa 3063721 tatcattctt tttatacggg tccatgagga caaacggcct aatccgttca tacatcgcca 3063781 tgattttcgg ttccatatat tctattgtaa aaagagattg gagcgttttt tctaacaggc 3063841 gcttgtagga cttgcgaaac tcggattcat ccaatatccg ggcggttagt gtattaaatc 3063901 cttgaattct tacataatcg gcagccatcc gctctccatg gatatccctg ccccaagtcg 3063961 catcataatc ccaaggaatc acctcaaata atccggtttc cccgcttctg tataatgcgt 3064021 agttgtggac aaacccgtca tagttcgagg tgaatacaat accagcaagc cagcgcaaat 3064081 acttatcgac atccacgtgt tttgtcactt ctgacttaaa ctgagcttta gggaccgtat 3064141 taattttaaa aatcatatct tgtaaataaa aatcatcttc ctcagtccct gttttctttt 3064201 catatccaag ctccagcgat gttttcgttt ccctttctaa atcgctcatc agagaaaagt 3064261 tggcatcatc atccaccgca taaaaaatcg cgccatcagc cagcttcctt ttcgccaaat 3064321 aatattcatc tacggattca agttcaagat aaaccccttc attcttccca ttcatcttta 3064381 caaacgcaaa ctctgccttt ggagacagtg tccctagctc cgagaaaaaa tccagagaca 3064441 atttgtttct catcaaggaa gggtctttat actccgcatt taagtgaatc tctcgcgcgc 3064501 cgcggaatgt tttcggctga taaaaggaaa tatggtatga cttctttttg aagtctctga 3064561 tatgtgatcc ccgataagcg atatcaatat ccagcctttt ttgatttacc ttcatcacag 3064621 ctggcaccgg atcatcgtcc catatatcct tttttaattc acgcaagtct tttggatgaa 3064681 caaacagctg ataaagcggt aaattggatt gattcttcat ccataatcct ccttacaaat 3064741 tttaggcttt tatttttata agatctcagc ggaacactta tacacttttt aaaaccgcgc 3064801 gtactatgag ggtagtaagg atcttcatcc ttaacatatt tttaaaagga ggatttcaaa 3064861 ttgggccact attcccattc tgacatcgaa gaagcggtga aatccgcaaa aaaagaaggt 3064921 ttaaaggatt atttatacca agagcctcat ggaaaaaaac gcagtcataa aaagtcgcac 3064981 cgcactcaca aaaaatctcg cagccataaa aaatcatact gctctcacaa aaaatctcgc 3065041 agtcacaaaa aatcattctg ttctcacaaa aaatctcgca gccacaaaaa atcatactgc 3065101 tctcacaaga aatctcgcag ccacaaaaaa tcgtaccgtt ctcacaaaaa atctcgcagc 3065161 tataaaaaat cttaccgttc ttacaaaaaa tctcgtagct ataaaaaatc ttgccgttct 3065221 tacaaaaaat ctcgcagcta caaaaagtct tactgttctc acaagaaaaa atctcgcagc 3065281 tataagaagt catgccgcac acacaaaaaa tcttatcgtt cccataagaa atactacaaa 3065341 aaaccgcacc accactgcga cgactacaaa agacacgatg attatgacag caaaaaagaa 3065401 tactggaaag acggcaattg ctgggtagtc aaaaagaaat acaaataatc taagttttca 3065461 ttgtttcaat aggctgccgg cggaggtacg gaagcctatt tttttatttg ccctgtatta 3065521 gatatatgtc atgacataac atatgcaacc cgcatcattt ggtttccttt aaaccatttc 3065581 gttataatca aggtatccta acgataaagg cggttgttgc tatgtacata tttcaagctg 3065641 atcagcttag tgccaaagac acatacaagc tattgtcagg taccgttatt ccccgcccca 3065701 ttgcatttgt gacaacactt tcttcaggag gagcggtaaa tgccgcgcct ttcagttttt 3065761 ataacgtcgt cagctcagat cctccgcttc tcagtatttc tgttaacagg acggaaggac 3065821 gccaaaaaga tacagcacga aacgcagtgg agaacggaga atttgtcgtt catgtcagtg 3065881 atgaagccat cattgaagat atcaatgaaa cagctgcaag cttaaggccg gatgaaagcg 3065941 agcttacacg cacctcgctt catcctgttg aaagcaaagc tgtttcagtt cccggcatta 3066001 aggaagcccg cgttcgcttt gagtgcaaat tagagcggca tattaccttt gacaatgatc 3066061 aaggcatcac tacagcagat ctgctcatcg gaagagttgt ctgcttccac ctagatgaaa 3066121 aggtgtatga tgcagaaaag ggatatattt taacggatga attaaagcct gcctcacgat 3066181 tggcgggaaa tcactatgcc aagctggggg aagaattcac actgattcgt cccagctgaa 3066241 gagaaggact atttaaatag aagaaactag tcaaaaagac cttatgatta caaaatatcg 3066301 cctgtaaata actgaaaaaa tatcaaaaaa aagaacaccc agagcaagct cggggtgttc 3066361 ttttatgaaa cgtttttcct ttttcttcgt ataaaggtag attaggagga attggaatga 3066421 caaacttttg gattttaatg ctgatcgcta ttaccatcag tctcgcctct caatttttta 3066481 taaagaaaaa atacggtatt gataaatccg gctggcgata taagcatgtc agcaatacac 3066541 acaaatggat cgaaatcact ttacttattt tgtttgtgtt ttcactctcc ttttttccag 3066601 ttgaatattt gcttctttta ttttttattg tgattgactc aatacgtatt tttatggagt 3066661 ggcattatag acctgaagat aaacagtata tgtaccacat tgtagaggtc tcccttatgt 3066721 ttatgctttt gatttatgtt tgtaccctat agttatttaa atccccacag ccgctccgtc 3066781 tccccgagga tcggctccgc cttggagaaa gccttcttca tcaactttga ttgcagccgc 3066841 ttgtcccatc agcggatcat agtcaccgac aacctccacg agatgcccgc tgtctttcag 3066901 tttttggatt gttttgtctg tgaatctgcc ctcgactctg agaccttcgt attcctctcc 3066961 ccacgttctg ccccataccc agcgcggttc gctgattgcc tgctgtggat gcattccgta 3067021 gtccagcatt cgggtaatga tggccgtctg ggtctgcggc tggccttcgc cgccttgtgt 3067081 gccgtacaga atttttggct ttccgccttt acagaccata gccggcatca acgtatggaa 3067141 ggtgcgcttt ctcggttcaa gcgtgttgac atgattttca tccagtgaga aaaacgatcc 3067201 gcggttttgc agtaatatgc ctgtatcacc ggcagtgact gccgagccaa attcaaagta 3067261 caggctttga atgaatgaca ctgcgttgcc atccgcatcg attacggccg catatgccgt 3067321 atcacttccc accggcctgc tttctgccgg tattgcgaga tagccgattt cttctgccaa 3067381 ttgttttgca taacgtttgt ccaaaagcct ttcaagcgga atgtctgcaa acgccggatc 3067441 agtcaggacg gcatcccgat ctagaaaact ctttttcaat gcctccacaa gcacgtgata 3067501 atactcaaat gaaccgtgtt cgatttgggt gaaatcatag ttttccaaaa tgttcagtgt 3067561 taataaaccg gtaaatccct gagaattcgg cggcgcctga tacacactgt atcctcgata 3067621 atcacttgat acaggcgctg cccactcacc ccgatgcgct ttaaaatcat cgattgtcat 3067681 gtaactgccg ttattctgta aatgtgagac aatccgctga gcgagatctc cttcataaaa 3067741 tgcgcttctt cctttttcag caatcaagtt cagactgtct gcaagctctt tttgcacaaa 3067801 ccgctctccc gggacaggtg ctttgcccct tctcgtgaag atgtcagccg tgtaaggcgt 3067861 ggaagccagc agttcaatat tcttttctgt gtgacgacac tgatcagctg atacaggaaa 3067921 cccattttgg gcataatcgc gtgcgggctc caatacatct gcaagagaca gacgcccgta 3067981 ctccttcagg accgcatccc agctatcaac cattcccggc acggtaatag cactgtcaat 3068041 tccccgcagc ggaatcgcgc tttttccctt atatacatct ctcgttacgt tttttcctga 3068101 acggccgctg ccattgtaga cttttactgc ctttgtttcc tggtgaaagg tcagccaaaa 3068161 ggaatccccg ccaagtccgg tcatatgcgg gtacacaacc gcaagacaag cactcaccgc 3068221 aacagcggcg tcaaacgcgt tgcctccctt atccagtatg cggtttccgg cttgagaagc 3068281 gagataatgc ggactgacga ccatttgctt tgtaccgatg acagatttgt tcatcacaag 3068341 tccccttttt taagaaattt tcttcagtat agggagcctg atttttcaca tctactgatc 3068401 cggcagaaaa actgacgaac tttcttcttt tcgcaaataa taagatattt tcgcattcat 3068461 ttcgaaaaca aatgaaaaat tattatttct atacgtaact tttatgataa aatgattgct 3068521 aaaaggctac gaaagcaggt ggagcaattg agtcatgaat atcaaatccc caaccttgta 3068581 cttgatgaga ctgataaaca aattctcacg attttgcatg aagaaggcag aatttcttat 3068641 acggatcttg gcaaaagagt cgatttgtca cgggtcgccg ttcaggcccg tatcaaccaa 3068701 ttaattgaag ccggtgttat tgaaaaattc accgctgtca tcaatcccgc taaaatcggc 3068761 atccatgttt ccgtgttttt caatgtcgag gtagaaccgc aatttttaga agaggtcgct 3068821 cttaagcttg aggaagagcc tgcggtcacc agcctttatc acatgacagg cccgagcaag 3068881 ctgcatatgc atgggatctt taccaacgat caagaaatgg aagaattctt aacaaaacgg 3068941 ctgtatccat tgcgaggcgt cgtcagtgtt gattgccaga tgctgatcaa acgatacaaa 3069001 agccgtatgg gaatgaagct gtaaaggaga gaaacaaatg aaaaaccatc cttatcggga 3069061 tatgacggcc gcaatggttc gcaccggcat attagggttc ggcggcggac cttccgtgat 3069121 tccgctgatc cgccatgaag cggtcaataa atataaatgg attgacgatg atgaattcgg 3069181 agaaatatta gcaatcgcta atgcgcttcc cggaccgatt gccaccaaaa tggctgctta 3069241 tctgggcttt aagctaaaag gcacattagg tgcaattgtg gcgatcctcg cccacattct 3069301 gcctacatgt cttgcgatgg tgggcttgtt tgcggctgta aatgtgttaa gccattcagc 3069361 aattgttgca ggtatgattg gtgccgtcac gccggtaatt gcggtcatgc tcggaatcat 3069421 ggcgtacgag tttggccaaa aagcgcttaa aggtttcggc tgggttaccg gcatcctgtt 3069481 ttttatcatc gcttttatcg gcctgcaaac tttacagatt aatcccggcc tggtcattat 3069541 cattttctta gcttacgggg cgtttcattt taaactgaaa gacaaaatca caaataaaca 3069601 ttcaaaagat aaaggaatgt cagcctcatg atatcgatct atttatttat ggcgtttttt 3069661 atcgcaaacc tactgggata tggcggcgga cctgcgtcta tcccgctaat gtttgaagaa 3069721 gtcgtaaaca gatacagctg gctctcaaac gatcaattct caaatatgct cgcacttgcg 3069781 aacgcattgc cgggcccgat cgccacgaaa atcgctgcgt atgtcggcta cagcgcaggc 3069841 gggtggcccg gcttcctaat tgccctgatc gcaaccgtcg taccgtcggc gctcgcattg 3069901 atcgtcctgc tgcgcatcat ccagcgcttc cgccaatcac ctgtcatcaa aggcatgacg 3069961 ctgtccgtcc agcctgtcat cgcggtcatg atgctcattc ttacctggca aatcggcgca 3070021 gacggcatca aagcgatcgg ctgggtccaa tcgatcgtga ttacgggaat ttcgctcctt 3070081 gccatgacaa aattcaaaat gcatccggca tttttgatta ttgcggcgtt tttatatggg 3070141 ggccttgtga tcccttattt atagaaaaaa gcacctggac aggtgctttt ttattttagc 3070201 ccagaaatgc cgtttgatat gacagctgtt tcttctcctg cgtcactctt gatcatgtgc 3070261 ttgacttgca gcgtggttcc tgccattctc acagattgct tcaactggga cgaattggtt 3070321 tcaacttgta tccaaacagg aggctggacc ttccaaaata aatagagtgc aagaatcagc 3070381 aagccagcaa tgaccgacag caaaaacttc atatcgcatc gcttcttttc agtaagcggc 3070441 tcgcagcgga cagcgcctga tgatcacgaa gaatatcgcc tggacgattg ccttctccca 3070501 gcacatagcc tttaaaggac attcccataa aatgaaaaat atgttcgaat tgctgaatca 3070561 gcggcagccc ttttattttt ggattgtctc cgcccactgc tattacatat gcctgtttca 3070621 ctgacatttg ctgtttaaaa tcaggaaatc tcggatctct caacgtctgt gaccagcgat 3070681 caataaacag ctttaatgtc cctgacatgc caaaccaata aattggggtg gcgaatataa 3070741 gaatatggca ctgcaatatc cgttcaatga tagaatcgta gtcatcttga acaggacgaa 3070801 agccgccttg ggcgtgacgc agatcttcaa ttggttgaat tggatatttc tgcaaataaa 3070861 tgtgctccgc atcgaatcct tgaacagcct tctccgcaag aacatccgta tttccgccag 3070921 accgagttcc gccgttaata accgcaattt tcatgatgca tctgctcctt tgtttacgaa 3070981 tgattttctt catcatataa tggattcatc aatcaataca gatgattatt tcgattaatc 3071041 caatcgctaa aaccgattta gaaaggaaga gaacaagtgg aattgaagca gctgatcacc 3071101 tttattacgg cggctgaaca tgtaaacttc accctaaccg ccaaaatgct taattatgca 3071161 caatcaagcg ttacctctca gatcaaatca cttgaagaag aaatcggaac gcctttattt 3071221 gaacggctcg gcaagcggct tatcttgaca gaagcaggaa aaacgttcaa atcttatgca 3071281 cagaagatca ttgcgttaac agaagaagcg aaaatggcca caaatcaagt aagagaaaca 3071341 accggaacct taaaaatcgg ggcgacggaa agccagtgca cataccgcct gccccctatc 3071401 ataaaagaat ttaaacaggc ttttccccaa gtaaagctca tattcaaacc atatatctcc 3071461 aatgaacaag cgaaagaaca gctcttacag ggccagcttg atatcacctt catcttggat 3071521 gtaaaccgga tggaagacgc actgcacgtt gaatctttga ttcaggatga gatcaaaatg 3071581 gtggctgcta atgaccatcc ttttcctgcg gatttaccag taacattgaa ggatcttcaa 3071641 aacgaaactc ttctgctgac agaggacggc tgctcgtacc gcacgctctt tgagaacaat 3071701 ttgcatgact ccggtatcta tcctaacaaa ttggaattcg tcagcataga agccatcaaa 3071761 caatgcgtga tggccggact tgggattgga atcttgcctg aaatgacagt aaaagatgat 3071821 attgcagcag gccggatgaa agaactcaat tggcagagcg attgccccgt tttcactcaa 3071881 ttagcatggc ataaggacaa gtggatgtct gcgccattaa aggcttttat cgatttgaca 3071941 cggaaaacat tcaaataaaa cctctccaca aggacgacaa ggtttttgag accagggcac 3072001 acacatacaa aaaaaacact tgatgactta gagccccaag tgttacacgt gatttttctg 3072061 ataaaacgtt cgcaaaacat gcgtctcaag gtcagccagg cggacaggga tcggcagcct 3072121 gctttcttga ttgatcaagc tcatcgtgat ctgatagctg ctgtctaaat caatataatt 3072181 accgcaagac aagaaaatag gcttcacgtc ccgccgcgtt cgcagcgccc gtccatatac 3072241 ctcgccgtca atgataatat cggtgtatgc gcctacttca atttcaggcg tcacgaaatc 3072301 gcagcctttg attttgagat aggttttcgc tatcccaatc gtcggcttgc ccagaaaaaa 3072361 agccgcatgg gtggcaacgc ccatatgatt gtaatgcaga tatccgttgc catcaaacaa 3072421 gaagacatcc ggctccgtct ccagcttttt cgccgcctcg atgatcaagg gcagctcgcg 3072481 aaacgcaaga aaaccggaaa catacggcac gctgattctc cccatgctgt gcactttttc 3072541 aatgacttct tttgtatcag cgtcaattac gataatacag cacactccgt atggttctcc 3072601 atcctgctcc caataggcca ggtcgacgcc tgcgcaggtg ttgatggagt ctggatggat 3072661 cgtgggggat aggttgatac gatttttaag gttaaattgc acttgtaaaa agtcttgttc 3072721 ctttttcata tcaaatttat gcacatcaaa taccttcata acgattgctc actctcgacc 3072781 taaattaatg tgagtctctc ttctcgattc tagtatttca aaatgaggac tatctgtatc 3072841 tatctcgtac ttatttaata gattgccttc ttcatcccaa ttcttttcag aaattagtat 3072901 ggaatgctca tactgttgct cacttttttt cctgccattt tcaaaccaaa ttatgcttat 3072961 accgtgcaat tgcccatatc ggtattcttt ttcacttttt ttattcccgt tttcataaaa 3073021 ttcacatgtt aaaccatggg ccagaccatt cttatattta gtaaaataga tgatttgacc 3073081 atttggatat aattcgtaag ccagccctgt aaacggctgg ccattttcgt cttcaggatt 3073141 atctaaaatc tcatcactta ccgaagagaa ccataaatcc tcaaagtcca ctcccttttc 3073201 ttttatactc ttcatatcat attcattttc catactttaa agcctccggt atataatttg 3073261 tattttgagt tatatattca caatgtggac atctaggcat tgggacacct tctggcatct 3073321 ttttatttat tttcctagca cttactacat ataccattaa atcttttaaa tccgcatcag 3073381 gtctttgaag taacgcttca tttagagcat taacttcggc atgagaaccc gcccctgacg 3073441 tctttatata accttcttta agttctgtag gcatatttac aattctatca tgaataagtg 3073501 gatgtagtac cttaggtggc ttcccatcta tattgtttat tccaaaataa taattgcctg 3073561 tttttttgtc caatacacca gctaccgcag ggcctctttg ttttttagtt agaccagaag 3073621 atttaattct actaagttcg tttagtactt ctgcccttag atttattcga tggtgaagat 3073681 cttctttaga caatacacca tgcttatttc ttaaatattg aagcctagtt tgtttttctt 3073741 cagtagtctt agcaatattg ctaataaggc tttcattact cactttattg acatatggag 3073801 catttttttg gtacaaccga tcaaagtagt gtgccaatcc tgctccacca ataatagtaa 3073861 tagcttccag cgccccttgc ttccgcttct cctcagacac tttgtttccg aacatatccc 3073921 ggcctgtgac agcttctgag aatccgtttg acgcaacaag gccgtatgcg cccatttctg 3073981 tcattttgag aatgtctaag gatttgcctg ttttgtaggc gtctaatgcg tgttcagcag 3074041 cgatagctgc ttttccggtt ttgtagatgg cttttccgcc tttgaaggcc cggcctgccc 3074101 agccgacgac tggtatgaat ccggcagcgg ccatagctcc tgctgtcaca cgctccgcgg 3074161 tggagagttt ttctccggta accggatcaa cgccttcggt tgctctttta taatcataat 3074221 agccagtgac ttctccagta aagttgcaaa ctccatccca tgttttttcg taccacggtt 3074281 tgtttgcttc ttcctcggct ttttcctgga gccgtcttgc ttctgcttgc tgggtttttg 3074341 catcgatata ggttgttcct tgattttcta cttcaatgac gcttttgtag acttcattgc 3074401 tgtggaaggc ttttttgtca tagtacatag gggatgcgct cttcccattg ctggtggcct 3074461 gcatgagaac agaatatttg gtgagcactg cgttgtccag agattctaaa ttttgatatt 3074521 cagtggtcag ggattcatca agcttatcga cagctgtgat tgtatcacgt ctgatttttt 3074581 gggcatcgcc catcttatct gcatagtcgt caagcgtgta catgtcgaga tcaataatat 3074641 cgctgatgcc tgacaaaata gaatcgattt cttctttatg agcggagaca atctctgagg 3074701 ctttcaggtc tccattgggc agctcatgat ccaaaaaaga agtttccaca tatgaatcat 3074761 tcagttcttg atctttaata tctcctgaaa tgccgtttaa aaacgcaatt tgagcagaga 3074821 caagcgtcag ccagctgtct acgatttctg cctgtccctg aaaaaaatct ttaatattgt 3074881 ccgcgccatt tcctttaaaa ttatcgccta aatcggcaac tccctgaaac gcttttttca 3074941 gcgtattcag ctgctcttca agcgtctcat attgcttttt tctgctcttc gcttcttcga 3075001 ttaaagattt tgattcaaat actttactca tcgcactgcc ctttctgttc tattttaccg 3075061 ctatcgcctc gtcctgctct ttgagtgaat ctacgttatc ctttgtatcc tcgatatttt 3075121 tctgtaccgc ttttttgtaa tctccgagca tggttttgat gttctcctca cgctcatggt 3075181 attttttcgt ataatcgagg ctgttttttc cgttggatcc tgcggcgccg attgatacgt 3075241 cagcaagcgc atctttgaca gaatctaatg ttttgatgac tgtgtcgtac ttcagcttaa 3075301 tttctgacat aaaaaaagat caccaccatt ttagtttact aattgtattt ccgacttctt 3075361 ccgcgaactc ttctcccttt ttaagaagat ctgctgcacc atttgctatg aacaattccg 3075421 atgcatattt agctttatcc cattcaagat caaaaatttt cccgttaatc gaagccatat 3075481 actcgttata tttatcattc acaatcttag atgcttccga tttcgcctct tctcttccct 3075541 tgtcgaaatc atcggctttt gttcccgtcc aatgcttgcc caattccggt ttcacaattt 3075601 ctttgatttc agtgattgcc tcttcttgca gtgtgtctat gtcctttttt gcttttttca 3075661 gcttttcgat cttgtcttcc acgtctgaaa tttttccgtt gagcgaactt ttgatatccg 3075721 ctagcatact ttcataaccc atctgaatca cctcttaata ctcaaaaagt cgtatggagg 3075781 ggctgatgaa gatagacttt tccatacttt atttccatat attatatttt aaaatagcca 3075841 gaaggcggct taaatagggt aaatggctta atttaggcat ataacgctct tgaaatgtag 3075901 gtatttgatc ttgtttttgt tcgttataca gctaataaaa gcgttttata aaatgaaatc 3075961 acctaatgtc atagttataa aggcacttga aagaggcaga tgttgttgat ctgcctcttt 3076021 cggcgctgag cttattgttc atgtttatgt tcttcatctg gtcggccatg tctgattttg 3076081 tcatttggct tctattattc cccccttctg accctttgga tcaaaagctt gtattagctg 3076141 cagtcccagt tgtacagaac gtttgaaaag tcttttttcc ttagatcttc aggtgtgatg 3076201 aaaaaattgg cgatgccgac gtctccccac attgaatcga tatcatcgtc tgaatcaatt 3076261 tgtaacagca tgatggtgtg ttctttatat gcgtattccc ggggatcatg ctgggtaaaa 3076321 gaagcgtatc cgccaatttt atggccaaat ccgttttcag ccagttcatt ataaatgtct 3076381 tcttcatcct cgccgaactg accaaagaac tccattgttt ccatgcccgt atactgctca 3076441 aattgaaaat ctgtaggcag cacccattcc gaagatttca caggctcgac tgccgcttct 3076501 gataaaatcg gaaaatcaca ttcgcctgtg ccaataaatg aaaaatcaga aacaagctcg 3076561 tcatcgtttt ctacgatatt ttcaaaatag atcactctga aattcttttg ttcacatcga 3076621 tcgtcaaaat tcaatccata gacgtcatca tgaacagaaa tgtagaactg caggatacct 3076681 gaagaagggt agccgtcaag ctggggaatg tgcgagaaat taatctgcgc cagaagtttc 3076741 atcggctgtc cattttcgtc agtcggatat gtttcatgct tggggaaata gggatcaccg 3076801 gcaattttgc tgtcatatcg tcctgttttc ccctttctca cattcagttt cacgtattct 3076861 ttcgctgatt tctccagcaa gtcgcggtac ggtctcattt tttcgggcag atgattcatc 3076921 agattctctc cttttccggc atctccaagg ttttattttc tggttttctt ctaatgtttt 3076981 tcaaacgaat gtttaaagaa gccctacttc tgcataattt tccaaacaat agttaaatag 3077041 tagcaaatgt attcagcacc ccgcaataga tgaaaaaaag actggtgcgc aaccagcctt 3077101 tctttttcat ctattgaatt gcacctgacg gaacaaccgc cttccgtccg acagaataat 3077161 actccactcc tgcagccaaa gcctcatcca atgtgtagca gtttctgccg tcaaatatga 3077221 gcggcgtttc catcaaatcc tgataagccg ctaacgggaa ttgtttaatg tcagcccagt 3077281 cggttaaaat catgacggcg tcagaccctt tgacagcttc ctcgatcgtc tctttatatt 3077341 caacagcttg cgggagaaca tgctttgcat ggctaactgc aatgggatcg taggctctga 3077401 tacgggcgtc gagcgcagcg agacggtctg caataacaat tgacggcgct tctctcatat 3077461 cgtcggtatt cggtttaaat gacaggccta aaagggcaat cgtttttccc gtcaccccac 3077521 cgagcctgtt cagcgcttta tcaaccagca tcgcctgctg attgttgttg actttgataa 3077581 cggatttcag cagttcaaaa tcatgctcga cattgccggc aatttgcacg agggcgtttg 3077641 tgtcctttgg aaaacaagag ccgccgtagc ctatgcccgc ttttaaaaac tggctcccga 3077701 tccgcttatc ctgtcccatc ccgtatgcga ctgcttcaat atcggcgccg accttttcac 3077761 atatattcga aatttcgttt ataaaactga tcttagtggc cagaaaagca tttgaggcat 3077821 atttgatcat ctcggcgctt ctgatatccg tttggtaaat cgggatttga aacggacgga 3077881 agagctcctc cagcgtattt gctgttttct catcggccgt cccgatcacg atcctgtcac 3077941 catgaaaggt atcatagatc gccgacccct cacgcaaaaa ttccggattg gatgcgaccg 3078001 aaatactgac aggctccgct agatgttcag taatcagtcc attaatcaaa tcgtttgtcc 3078061 caacgggcac tgtgcttttc gttaccacga ctgtatctcg tttgacatgc tttgcgatgc 3078121 gtttggccgc atctgtaatt tgctccagat tggcgtgccc gtcgcttttc tgcggtgtgc 3078181 cgaccgctat aaaaatgatg tctgcctgtg ccaagccttt ctcatagctc gtttcaaagt 3078241 tcagccgtcc atcagctgta ttttttctca tcagctcttc aagacctggt tcaaatatgg 3078301 gggaaatgcc ctttctcatt tcatcaatct tgtgagcgtc aatatcaatg caggttacat 3078361 gatgtccaat ctcagaaaga gaaacacctg tcacaagacc gacatagcct gttccgatga 3078421 ctgttatatt cattgtttcc ctccaacagt taaattgctg ctttgcagct tccgtaatat 3078481 cgtatgagaa catcctatca tgaatgcgaa tgatctcccg catagcctgt cgggtacagc 3078541 ctgtacagat ttctgaaatg tgattcaacc atacaataca ctattatatc gctctcaaaa 3078601 agaaagtggt gaaatgagaa tcggctgtta aaaaaaacca aacaattttc ttcttttgac 3078661 cggctgcgga ggctgtctga agatggtctg attccgcagg agaagctctg cattttccgt 3078721 cagcatataa ggaagttccg agccgaattc tttctctaga acataaagag cctcttgagt 3078781 gtgaaaattt ctcgttttca cattatgggc atctgaggct acgaaatgga tcaaattggc 3078841 ttcaaccagc cggagagaaa atgctttcag ctgcttgccg aagatccccg caagacttcc 3078901 tgaagtaatc tgagatgctg ctcctttttc cacaagatga tacagcaagg acgggttttc 3078961 gcgaatttcc ctgttgcgtt caggatgggc gataaccgga atatatcctt tcagctgcaa 3079021 atcataaaaa agctgctccg catatcgggg aacgtgatca aacggaaact caatcaagat 3079081 gtattttgta tcattcagcg aaagcagctg acgtttggca aggtcttgtt ccacctcgcc 3079141 gtagattctg atttcctgtc ccggaagcac atgtaaagga atgtcttctt tgattaaacg 3079201 tttgtttaac tgatctgctg cttctctgac tgcggctggc tcgtttttat acacaccgtt 3079261 gttatgatga ggtgtcgcaa tgatcgtccg gattccctga cgaacagctg ctcttgccat 3079321 ttctatgctg tcggccgaat cacctgcccc gtcatccatt gcgggaagaa tgtgacagtg 3079381 aatatcgatc atgtcctagc cccctttttt cgcaaaaata aataacgggc acgatgcacg 3079441 ttatttattt ttgcatgaaa ttgtccttgg ttccgtaata tccgtattca gagtgcttcg 3079501 aaagcttttt gccgttcata atcgccccaa ggagcttgct tttgcacgtt gcaagcgcct 3079561 ctttcgcttt tgcggcttgt tctttttctg ttttcccgct tgaaataacc agaacagaac 3079621 cgtctgccac gttgcctaaa atctgtgcat ctgctacggc aagaataggc ggcgtatcaa 3079681 aaatgaccat atcatatgcc gcacacgctt cgtatgcaag ctccttcatc cacttcgagg 3079741 agagaagctc ggccgggttt ggcgggatcg ggccgctcgt cagcacgtca agatgttttt 3079801 cattcgatgc ttgtacagcc tgctccatag agcttttctt taataaaaca gatgttaagc 3079861 caaccgtatt ttcaagaaaa aaagccgtat gtactgttgg ttttcgcaaa tcagcatcaa 3079921 tcaggagcac tttttttccc tgttgggcga atacgacagc caggttggcg gccgttgttg 3079981 attttccttc ccccggacaa gccgatgtaa tcatgactga tttcatttgc cggtccactg 3080041 aagcaaattc tatattcgtg cgaatcgtcc gatattgttc agagttcaag gatttcggct 3080101 ctgtcattgc aatgacattt ctctgcatcc gcgagcctct gttttttcta agcgccaaaa 3080161 tgtccactcc ccgttttttc agattggaaa ccctgtaagg tctttgctgt tttctgctca 3080221 ttcgcaatgg tggaaactgt ccctaaaaca ggtatgtcca gcaaggattc gagctgctct 3080281 tccgatttga tcgtattatc caaatgctca agcaggaagg ccagtccgat gcttcccgcc 3080341 aatccggccg caaacgcgat ggcaatgttt agtagcggct ttggcgatac aggggacggg 3080401 tgttctgaaa cctcggcttt tgacagaatg ctgacattgt caacattcat aatggatgtg 3080461 attttgtctt gaaaaacaga tgctatagta ttggcaatat gagccgctgt ttccgcgttt 3080521 tcatccctga ctgatatgtt gaccacttgg gagtcctgtt cgctggatac ggtaattttg 3080581 tcattcagtt cttgggatgt catcgacagg cccatttctt taatgacttc atctaagatg 3080641 gcagggctct taatgatgac attgtacgta ttgattaact gaagattggt ttggacatcg 3080701 ttaaattgga cttcttttcg ttcatttttc gattggttga ccagaatctg agttgaattt 3080761 tcatagatgg gtgtaagtgc gaagaaacta atgagtccgc cggcagcagt ggcagccgcg 3080821 gttacaatca taatcaaaag tatgcgtttt gttaacgttg ataatatctc ttttaagctt 3080881 gtagattctc ccatgatacc tccaaatctc ttataacatc cttttccatc tacgattata 3080941 caacgttgaa accgcatttc tccagctttt cacgtgacat aattcgacat ttttttacaa 3081001 tgcgttatgt tagtactttt tatgtaagcg ctatatttac tgtgttgaca gtgctgtctc 3081061 attttctctt attcgggcag tcacgttctc tcgcataaaa aaatcccgct aaaggcgtgc 3081121 gggattttta tgttgcatat ccatttttaa tatgagaaat caaattttca agcatttcct 3081181 tcgtcgtcat ctcagatgac tgctcaccaa tttcatgtgc atgcatcaaa attttcagaa 3081241 attcttcttg attcaatttc ttttcactca tctttttttt cctttcagct tccattaagt 3081301 tgaaaacacg attattatat gatgctggtt atcaatttgc aatctctaat acatcattcg 3081361 acacatccta ttttttatgt ccttttttag gaaaaacttt ttaaggccga tgtgttgcga 3081421 tataatagag aaattggatc tttttattac gtgactcggt taggagcgat aatcatgctt 3081481 cagaatatga tttccaaaga cgatgtgctg gcatctgctg aacagttaaa agaacttctt 3081541 ccttacaatg aggaaaatgt tcagctgatc aaaaaagccc ttattttata tcggcaggat 3081601 tcagtctatc gtttacaagc agtgagtccg acggaagtta cggcttacgt gcaggatgtt 3081661 gtgcctgtgc gggtcacatt gaacttgttt gtcatagtca aaagcggctg ttcatgtccg 3081721 tccggaagaa tctgccgcca tatgctggct gtgtttttat atgtatatgc aatgttcgag 3081781 cgagtgggta cttttacaga gtattggctg gagagggaaa agcttgagga aagcaaagag 3081841 ctcgtccgcc gccagtttca ggaaaaggtg ctgcctaatg aagaatcact ttcaagctgg 3081901 cttgcttttt ttgattcaga gttttctctc tggcaggcac gtacgccaga aggcagccaa 3081961 aacatgcagg gcctctatta cggctacctg tccgcattaa aaaaacatgc gccgaacaag 3082021 ccggagctga aaagcctgta tcagattcat tccgcgattg cggtttggct tcgcatgttc 3082081 acattgattg aagcgggcaa gctaaacccc gaacaagatt tttattccct caatccgtac 3082141 gttgaacagc tgatggatac aatctacagc tctattgata aattaaaaac gtacgcgctg 3082201 tcttttgcgc ttgatccgtt tttggataaa acaccggatg ttatccggca tttgctgttg 3082261 aaagaagaaa ttttccaata tgaacgcatc cgcgtcttcg gtgaaatttg gagtgcgctg 3082321 ctgtcgcggc caaaatgggt ggcacgcgaa caggagatat tgaaaaaaga agcaggacgg 3082381 cgtttttctc ccgaattgca attcgggcgc ctgcatttgg aattcctgca aaaaaatgat 3082441 gacgttattt ttgaggaagc ggatcaattc ccgccggaag cgctccctta tacattccaa 3082501 tggctgagtg aaatgactgc caagaaggac tggaaacggc ttaaaacatg gtaccagcaa 3082561 attgaaccaa ttgcgatggg ttatacgaag ctggataagc cgtttaaaga gattcgcgat 3082621 gtgatcggcg agctgttcct tctgttgaat gcctatgtgc agcaaaccaa tgatcaagcg 3082681 ctgtttgagc gctttgccgc gggctgtctg ccgtatacgt tcacagaata cagccatcat 3082741 ttatatgaaa aaaaacgcta tgccgagtgg attgaaattc atagccttgt cggcttttcc 3082801 atcaatgaaa tggataaaat gatgctcaag gaaattgcag cgagcgaccc tgaggcgctt 3082861 ataccggctt accatagaga agtggctttt ttcattgatc agaagaaccg tagctcgtac 3082921 aaggaagccg cccggtattt gaaaaaattg cgcaccctgt acaaaaaagc gaaaaagcag 3082981 aaggtgtggg agcggtatat tcagctgctg agctcgcatt acaagcgcct gcgtgcgctt 3083041 caagaagaac tgcagaaagg aaagttgatt gatggcgagt cttaaagaaa ttctcatcca 3083101 cgtcgaacaa atggaagatg ggtcatttac gctctcagcc tttgatgaga atgagcagcc 3083161 tcttccctac agccatatga aaaagcattt gttccaatgg catgaatcct cattttacgg 3083221 aacctttcta gaggatgtca gcttcatcgg gacgactgct gtccttctat ctccatggat 3083281 gactgtagag cttctcggca aaaactcgtt caactcattc agctccgtgc agcttacaga 3083341 agaaacggag ccgctgatcg aggcggcatc gaccatctat gaatttatcg cggacggcga 3083401 ttttatgcct gactatgacg catggacaaa cggtgttttt cgctggaagg accgcgataa 3083461 tatactggaa ggctttactg cggaatggtt ttccgctgcc gtacaggatt acatccagta 3083521 cgacgatgac ctgcgggaga aatgggaaca tatcaaggaa aaatcgcctg cggttacgac 3083581 attccgtggc cattttcttg atgaagagga ttttctggaa ggcattggct ggattgacga 3083641 tcaatctcca tttactgtcg gcttgcgctt aaatgaaccg gactttgacg gagacgaatg 3083701 gaagatcgag atgtttttac gcgataaaaa gagcggtgct gtagaattct ttgacggact 3083761 gaagagcctc aaaaaatcgt ggcaggcgta cagcgataaa atcgcgcgtg agcaggaccg 3083821 ctttcacaga acggttccgt ggctgtcgtt tgattccggg acaacgctga tctcggagga 3083881 agaagcctgg atcttcctgt cagaagcaag tgagacgctt gtcgatatgg gggtagaaat 3083941 cctcctgccg tcctggtggc agattgtcag agacagcaac atgatgctga aagcaaaggt 3084001 gtcttcctcc ccgcgcggcg agtcatttgt cggcatgaat gcactgcttg atttcaactg 3084061 gcggtttgcg acaaatggaa ttgaactgac tgaggctgaa tttaatgagc ttgtcgccag 3084121 caacaggcgc cttgttaata tccgcgggca atgggttaaa atcgatccgc agtttatcaa 3084181 acagatgaaa cgcctgatgg aaaaagcaga atcagaggga ctccacatgt ctgatattct 3084241 ggcgcgggag ctaatggatc agcaggatgg cggacttgag gattcggacc tgattgatac 3084301 atctgctttt gccggcattc agtttgatct gtctaaacag ctcaggtcac tgattcgaaa 3084361 gctcactgcc gcggaaaacc tgccggagca caaagtcagt ccttctttca aaggaacgct 3084421 ccgcccttat cagaaatacg gcatgaactg gctgctgttt ctgcgggaaa gcggttttgg 3084481 cgcctgtctg gctgacgata tggggcttgg gaaaacgatt caaatgatcg cctatttcct 3084541 tcacgtgaag gaaagcggcc gacaaaaaac gcctcatttg attattgcgc cgacatccgt 3084601 acttggcaac tggcagcggg agcttcaaac ctttgcccct gatctgtctg tcgcgctcca 3084661 ttatgggccg cgccggccaa agggtgatga tttcgccgcg cattatgaaa acgcagacgt 3084721 ggtgctcact tcatacggtc tgtcacatgc cgatactgaa gagctttctt ctgtgacatg 3084781 gaacacgatc tgccttgatg aagcgcaaaa tattaaaaac gcgcatacga agcaatcacg 3084841 cgcaatcagg aagctgaagg ggcttcacca tatcgcgctg agcggcacgc cgatggaaaa 3084901 ccgactgact gagctgtggt ctatttttga cttcatgaat aaaggctacc tcggcagttt 3084961 gaccggcttc cataaacgct atgtgctgcc gatcgaaaaa gaccgggacg aaaagagaat 3085021 cggacagctt cagcaattaa tccggccatt ccttctccgc cggacgaaac gggatgaaga 3085081 ggtcgcgctt aatcttcctg agaagctgga agaaaaagaa tttatccctc tgtcagccga 3085141 gcaggcatcc ctttatgagc agctcgtcaa agacactttt gaccatatga catccctgac 3085201 cggcatgcag cgaaaagcgc tgatcctcag catgcttgga cggctcaagc aaatatgcga 3085261 tcatcccgcg ctttatttaa aggaagagca aaccgagctg ctggccggca gatcagtcaa 3085321 gctcgaaaaa ttgctggaac tgatgacagc gatccgcgcc caaaacgaaa gctgcctgat 3085381 tttcacgcaa tacattcaga tggggaacat gatgaagcgg ctgcttgaaa aaacgttcgg 3085441 ggaacctgtg caatttttaa atgggagtct ctccaagcaa gagcgggata cactcgttga 3085501 gaaatttcaa aggaaagaat atccgacact gattctttca ctcaaagctg gaggcaccgg 3085561 acttaatttg accgccgcca atcacgtcat ccattatgac agatggtgga acccggcggt 3085621 tgaaaatcaa gcgactgacc gtgcataccg cataggccag gagcgctttg tccacgttca 3085681 taaaatgatt acgacaggaa caatcgaaga aaaaattgat gtcatgcttg aatccaagca 3085741 aaccctgaac gatcaaatta tccaaagtga aaactggatt accgagcttt ccacacagga 3085801 gctcgaagaa ttgtttacat taagcgctac agcgcaataa tcatgactaa aaaagctggc 3085861 tctaaaagag ccagcttttt tccgttcata gccgtcacgc cgaatttcca aaaaatccgt 3085921 tacgccggtt atcaacaggg tgcgcttttg tggcagcaca tatacttaca acaaatgttt 3085981 catcatatgt gcgacaccgt gttcgtcatt ggttaaggtg acagcatcgg ctatcgattt 3086041 gatgtcttcc cgggcattgc ccatcgctac accttttccc gcagcctcca gcatcgattt 3086101 gtcatttaaa ctgtcaccta cagcagcagt ttcctcgagc ggaatattca gctgttttgc 3086161 aagcctcttc agcgcctgcc ccttggaagc tttgcgggaa gaaagctcaa agttgtgctc 3086221 agccgaactg acaagcgtca aatcttcggc atgctcatat cttttccagc ctgcctcaag 3086281 cttttctttg aagaaagaaa agccgagaat attgtaaaaa tcgattggct catcggcttc 3086341 aaacagctct tgaaaggagt taatgtaagc aaagcccgat tggctgtatt gcacctcggc 3086401 cgcctgctta aggacagaaa gatccgcttc cggatttgcg cttctgaatc tgtcgagctc 3086461 aacatcaaga agttctctgc cgttttgcgg cgtataaatc gctgaacctg tgaatacctc 3086521 ataataatag ttttccgact caagccatga gagaatgtca tacgcccgtt tcttatcaat 3086581 cgtttcgtga tgataaagcc tgccctcggg atcgtgaatg acggcgccgt ttgcactgat 3086641 gacccatgtt ttgatcccca gcggttcaaa gattgacatg acgtcaaaat gagcgcgccc 3086701 agttgacacc accacttcaa tgccgtcccg ctgcgcctgc cgcagtgcgt tttcattttc 3086761 caagcttacc tgatgcttgc tgttgagtaa ggttccatct aagtcaatcg caattaattt 3086821 cacgtttgtc agtcctttcc ttcatcctgc tctgtcacga gaagctcaac gccgtttcgg 3086881 tcaagcaagt cacaaaatgc ctgattcggc agcctgtctg taatcaagag gtcgatttca 3086941 ttcagctccg catactgata aaaactggtg ctgcccagct tagaatggtc tgcaagcgca 3087001 attacctgct ttgcctgctg tatcattttc cgcttcacca tgccatcctc ttcatgcgca 3087061 attgtaatgc catgttcgga aatgccgacc acaccaatca gcgctttatc aacatggtag 3087121 cttgagagct tttcaatcac agaggacccg tacagaaagc ggtgctcctt ttccagcttg 3087181 cctcccagca gataaatttc aattccctct ttatcggaca gcacatccgc aagattaatc 3087241 gaattggtga ttacggtaca atcaaccgca ttcaaatgct ttgcacatgc ctgaacagtt 3087301 gtagaggcgt ctaaaatcac ccggtctcca tcatgaataa gcgatgctgc aagcctgccg 3087361 atcttatttt tttcctcaga cactgttttc aggcggccgg aatagctttg aattttctga 3087421 tgcacagtcg gtaaaatggc gccgcctctt gtgcggatga tggcattctg ttcctcaagt 3087481 ttcacaagat ctcgtcgcgc tgtatccctt gacacttgca ggagcgtaca gatctgctcc 3087541 gttgtaattc ggttatgctg ttttaaaaaa tccaaaatcg ctactaatct ttcttcttgg 3087601 tacacgccct cattcctttt ctcagcaatc atttataagt aattataagt ttttatttga 3087661 ttttattcaa cattaataag tgattttaag taaaaatgcg tcgagagaac caatttttcc 3087721 taagtaggca aaaagaaaga accagtctgg tcgactggtc aattttgagg ggatgatgcg 3087781 aagatccgga taatagtgaa tggatagata acgggaggag caggggtgtc aatcagcagc 3087841 tttttcccgg ggtttagggt ccataaaacg aacagtgtca gccaacactt ctgttacata 3087901 cacgttaacg ccttcctcgt tttcatagct tcttgtctga atccgtccgc ttacgccgac 3087961 gagagaacct ttttggcaat acaacgccgt gttttcagct gtttttctcc aaagtgtgca 3088021 attgacgtaa tcagcttcga tttcacctga agcattcttg aagctgcggt tcaccgcgag 3088081 cgtaacatgt gcaactgccg caccggcgga agtgtagcga agatcaggat cttttgtaag 3088141 acgtccgaca agcatgacct gattgaacat gcgattcctc ctctccttgc ggttgtatgt 3088201 attgtaaatg atgcaacaag aaaagaaaaa cgcttaaaaa tggctttcag cctctgtttt 3088261 tatctttcgt tttcattttt ccttcagcta aaaacatctt ttgctttttt cctttgaaga 3088321 aatatgtact ttttaaaaaa cggaaaaaga tttgctttgt cagccagttt tgcgtattca 3088381 tgcgcacata ggaagagcca tcccacgcaa accactgaaa gctcaatttt ttttccggca 3088441 ttgacagctt gattttatac tgctccatgc catcttgtgt ttcgtataaa aaacttattc 3088501 ttcctttttt gttcagatga acctcaaaca cttctttacg gcttaacata tatgttactt 3088561 ccttttgaat caaatgactt tcagaaggaa cgccgtcaat ataaatttct tttaaacgaa 3088621 attgattcat accacatctc tccgtaatcc atagtcagtt acagtataat gaaaaaatag 3088681 aaattattaa atgtttcgct catacaaaat tctttagccc caacattgca ggattttttc 3088741 ctcgaaaacg tttatgttat aatggaaggc aagaaaactt tggaagtaat cggggtgaga 3088801 agaaatgaaa acctttaaac tggttgacct gaatgtggaa cgagtggaca aggaagaaca 3088861 atcaattgaa cagtttcccc ttattgacgg actgattata aataaagaag acggtgaaaa 3088921 tcactggctg attgaggcgc ttgtacagaa agaacatctg tctttttttg aacagcttca 3088981 aaacagccaa tctgaagcca aagtatttgt aacgatcacg aaaaaaagca atcgccccgc 3089041 ccagctgaca gcagcagtga aaaatatcgt caagctggaa gaaagcattc aggttttact 3089101 ctacggacaa atggtcacaa gaaaacagca gggcactgaa accattctcg agtcccttgt 3089161 aaaagagggc tatacaggaa caaaactcat tgaggcattt aagcaaaaat tataaatatg 3089221 agggggcatg ttccccaaaa cagactcaga accgaagagc atcacaatag acatttagaa 3089281 tagatatgtt ctgcatgaaa aaagctgccg ttttgaacgg cagcttttct cttcgtgctt 3089341 tcactcttgc atatttaatt tgtatggcca aaagaatcaa ccaattcccc tttcacaacg 3089401 aggcgccctt cggttttgac cgccttgtca catgtgatta acgtaatctc ctttttgttt 3089461 gtctcctcaa ctacatctgc atccatttcc gatatgatgt ctttcgatgt tacagaatag 3089521 atataatcct ttttaaaatc cgtgatgaca atttgggcac ctgtttttat gttttccaga 3089581 ggtccgaaca gaagattctt ttgcttcaaa tgatggcccg ccaacggata atttccctca 3089641 cccatttttt gatcccggcg cattgttgcc gcccctatca aaagattttc attggttgtg 3089701 ccttttacga tcggaagctc cagatcgaca cttttaattg ttatccgccg ccttgattgt 3089761 gaagtaaaaa taagtatatt tcacgtgctt tcgacgttct ccacttgact ggaatgcttt 3089821 aatggcgatc ccggcatctg tagcttcagg ctttccttca gaggaatcag aaatctcaaa 3089881 ctctattttc tcagtgttca gcacataacc ggctggcgct ttcgtttcaa caaaagcgta 3089941 ttgtcccggt gcaaggcctg aagctgtgac ttgatgatgc cggatatgac tggtttcgaa 3090001 gtctgtatga aaattcgcga acgattcagc atggttgatc ttccggttct gatcattaca 3090061 gctgccatta tcggccatga caaatacaag gcttttcatg ccggagcgaa tgacattttg 3090121 caaaaaccct atcattactc tgaatttatg gcgcgtattc aaaacctgat aatgatgaaa 3090181 catacagcaa atcaagccac aagaatggaa atggcgtttc tccagtcgca aatcaagcct 3090241 cattttcttt ataatgtatt aaacacgatt atttctctca ctcatttgga tattgaaaag 3090301 gcccgggagg taacagagga atttaccaac tatttaagaa tgagttttga ctttcaaaat 3090361 acatcagcca tcagttcctt cagacatgag ctttcgatta tcaattccta tctttctata 3090421 gaaaagacgc gattcagtaa tcggcttgag gttcttttcg atatagatga agacattgac 3090481 tttatccttc cgcctttaat gattcagccc ttggtggaaa atgccgttct tcacggtgtc 3090541 agcaagaaaa gaggcggagg atggatcaaa ctgacagcta aaaaacaaag caaaaatgag 3090601 tatcacatca aagtagagga taacggtccc gggataactc cggaaaaaca aatagatctc 3090661 ttatcaacgg attttgatcg cagcgtcgga ttgaaaaata tcaatcagcg gctgaaacat 3090721 ttttgcggaa gcgagttgat gatcagcagc actccggatg caggcacctc tgtctcaatg 3090781 ctcattcatc tcgctgaaac aacaggaagc cctaaagaac tgaaggacac agaacgaacc 3090841 taaacgaaaa ttgagataaa aaaagacgcc gtttctaacg gcatcttttt tattccggcg 3090901 actttgcttg ctgcttcagc aggtctctga tttctttcag cagctcctcc tgcgcatcca 3090961 ccgcttcctc cgcagcctct tcttctgctt cttttttgcg ccttaaccca ttcaaagtcc 3091021 gaatgacgat aaaaatggag aacgatataa ttaagaagtt cacaatcgtc tgtataaagc 3091081 tgccatattt cactacagca tcgccaaacg taaacgacag gcctgaaaag tcaagccctc 3091141 ccagcagcaa accgaccaaa ggcataatga tatcatttac tagagatgtg acgatctttc 3091201 cgaaagcgcc gcctatcaca acaccaatcg caaggtctac gatattcccc cgcatggcaa 3091261 aggctttaaa ttcattccac atacaatcac ctgcttttct atatttgtaa agaaaaaaag 3091321 acaaatgtgc cgctggccat ctgccttttt tcaattattc tccgagggca aaagtcagtt 3091381 ctacttcgca aacgacttcg ccatcaactg tggcaacgcc ttttccgcgc ccgattgtgc 3091441 cgcgggcacg aatgatttca acctcaaggt gaagctggtc accaggcttg acttgttttt 3091501 taaagcggca gttatcaatg cctgcaaaaa aagccagtct gccgcggttt tcttctttaa 3091561 tcaacatcgc aacagctccg acttgagcga gtgcttctac gattaatacg ccgggcataa 3091621 ccgggtactg aggaaaatgt ccgttaaaga actcttcatt agcggttaca tttttatagc 3091681 cttttgcccg tttgccctct tcaacttccg taatccgatc cacaagcaaa aacggataac 3091741 ggtgaggaat aatttcttta atttgctgag tatcaagcat tgtcttgaca tctccttcat 3091801 ctgcattagt atgtatagca atcatcaaag atccaatctg tacatttgaa aagtatatta 3091861 tgaattaatc tctttttcaa ccgcgctaaa atgtaaccaa ctgtcaatga gagccgtcaa 3091921 aagttatgat atgataatta tagattttac caatagcaaa gaggtaggaa aatgatttcg 3091981 aagtttattg aaaaaagaat gctaaacatg ttagacgagt ggtattccgc aatgagcaaa 3092041 cgcaaaatga atcacgtttg cacactgaaa gagaaaattg atcagcacct tccaaagatc 3092101 aaaaagaaca caaaactttg gatgcgttat caattgtttc aggcccgcca tcagctgctt 3092161 tttgaaaacc agaacggact cgattcattg ttcgatggcc tatatggcct ggaagacaaa 3092221 atggatgatg aattgaaata ttatctgtat tttttctctg ggttatatga gatggtaaaa 3092281 acagctccga aacatgcagt acatcatttt aaaaaagctg aacagtacct ggccgccatt 3092341 cacaatacgt ttgaagccgc tgatttatat tatcaaaccg ccggcgccta ttacttgatg 3092401 aaatcaccgc cgctttccgt ccaatacgtc aaaaaagcat tacacatcta tttgcaccaa 3092461 ttcggctata tcaaaaaggt aatcacctgt aaacttttgc tcgccgtgaa ttatattgat 3092521 caagaacgct atgaaaaagc tgaacagctt ttcaaagaaa tcattaagaa aacccagcaa 3092581 ctacatgacg aaaacctgct atgccacgct tattataacc ttggcttttt aaaagcgacc 3092641 gagaaaaaag accaggaagc gcttctttac tttagaaaag tattaaagaa tcaagaattt 3092701 gaaatgaatt caccagtctc atatcttcat tgtgtgtacg agtctgtcag agcgcttttt 3092761 aaaacaggga acatcacaga agctaaagcc gtccttcaaa aaggaaaaga attatctgaa 3092821 aaggtagaca ttcaaaccat ttatttaaaa ttaaaaacgc ttgaagccct ctacacatca 3092881 gccgaagacc cttatgagca gctgctcgaa tatgtgcttg aattagaaaa aatcgaggcg 3092941 tgggtggatt tagaagtgct gttagaagat attacggaat actacaaaaa aaaggacgat 3093001 ttcgaaaaag ccgctttttt tatcatgcgc ggctgattga aaaacgccca ttttcttatt 3093061 atctgactga attgattaaa ccgagcattt gatctcccat tgtgatcgtt ctgctgttca 3093121 gctgatatga acgctgggac gtgatcaaat ctgtcatttg ttctgaaata tcgacattgg 3093181 acatctcaag tgagccctgc tgcatgccga tgttttgtct attagcgccg ttcagctctt 3093241 caaaagctgc cgcattatca atagagaaaa ggttattccc ttcggatttc agctcttgag 3093301 ggttattcac ttggacaacg ccaagattaa accgctgaac cgcgtttccg tcagatgcgg 3093361 ttaaggtgcc gttcttatta atggtgatat tcttcattga gctgtcgatg ttcactgtat 3093421 tgccgttctc atcaagtacg ggatacccat ttccagtgac gagctgcagc tggttggcat 3093481 tcgcagcgga cggcgttaca tacagcgccc cgtccctcgt atactggcgg tttccattta 3093541 catttacctg aagatactgg tatggagacg taaatgcgat atccagatcg cgatcggtct 3093601 tctgaatgct tccttgatca gagactaggc gtgaactcat catcgctccg acgccaaggc 3093661 gcaagccggg cggcgttttt cgggcttttg ccacttcctc gtttttttca tcaacctgat 3093721 cgaattgctg tctgacaagc tcagaaaaat tcgtatcttt tgccttatag ccggttgtgt 3093781 tgctgtttga aaggttgctg ctgattgtgt caatctgctg ctgcagctgg tttaaggttg 3093841 ttgatgccgt tagcattgac ctgagcatag ttgatgtccc ccgttttttt cttccgtttt 3093901 cttaaatttt tccaatttca tttgctgctt tatccatact tttatcgtaa gcctgaataa 3093961 ccttctgatt cgcctcaaac gatctgtacg cttcagtcat ttctgtatag gcgcttgtca 3094021 catccacgtt tgaaagctct gagacgcctt gttttaatga ataggctacc tgattatttc 3094081 cggctgcgct tggcagatca ttaccgtccg ccgtgctgta caaatcattt ccgtcccgtt 3094141 tgagattgcg gacatcttcc gccattctga catcaatctg gccggctgtg cgtccgttcg 3094201 ttgtcacagt accgttttca gacacagtga aattctcatt atcaacagtg attggctggc 3094261 gatccgtcga taaaataggg cgtccgttga tcgtcagctg attgttctca tttagtgaaa 3094321 atgtgctgct ttttgaataa cggattccat ccgctgtttg aaccggataa aaaagagcag 3094381 ctttttcatt ggtttccgca ctcatcggaa cttgattttc gatcaatgca atgtctgtag 3094441 gctggtctgt ggacttcagg cttccctgtg taaagagagg cttgagctcc tgcatatata 3094501 ctccggtatt cacggaaccg atttccgtcc ttgatgtccc ggccggagat tttgattcta 3094561 ttctgctgag cagcatctca gggaacgcgc gcatagagcc ttgatcagct ttatatcctg 3094621 atgtatttgc gttagcaata ttatttgaaa gcatttccgt tcttcgctgc tgggcaatca 3094681 ttgcggatgt tgctgtatat aatcctttta acaaatttcc cacctctaaa aatggcattt 3094741 tttccagttg tcatatagga acgttcgttc tataataaaa actcagtatt ttatcctatt 3094801 atcgtcattt aacatctttt cgtgaaggct ttttcataaa aaaacctcat tctttttcag 3094861 aatgaggttt gtgaaatcag cttagtttgc gtttaggaag cttgtccata ttatcaagca 3094921 tgacacctgt gccgatggct acgcaatcca taggattttc agcaacgagg accggtacct 3094981 tcagctcttc agcaagcagc tggtcaaggc cgtttaagag cgcgcctccg ccggtaataa 3095041 taacgccgcg gtcaataata tcagcagaaa gttcaggcgg tgttctttcg agcacttgtt 3095101 ttgcagcctg aacaataaca gcgacagatt cacgaagggc ttcttcaact tctttactgt 3095161 ttactgtaat tgttcttgga agaccggaaa ccatgtcccg tccgcgaatg gaaatttcct 3095221 cgtgacgtgc gtctgggaaa acagttgcga ctttaatctt aatatcctcc gcagtacgtt 3095281 cgccgatcag cagcttgtac tcgcgtttga tataatttaa gatttccatg tcaaacttgt 3095341 ccccagccat tttaatagaa gaggaggtga caatatcgcc cattgaaata accgcgatat 3095401 ccgtcgtccc gcctccgatg tctacaacca tgttaccgct tggctggaat atttccatac 3095461 ccgcgccgat agcggcaact ttaggttctt cttcaaggta cacatgtttc ccgccgcttt 3095521 tttctgcagc ttctttaatt gctttttgct caacggatgt aatattcgtc gggcagcaaa 3095581 tgagcatgcg cggctttgag aacaggcctt ttacattcag cttgttaata aaatgtttca 3095641 gcattgcttc tgttacttca aagtcagcaa taactccgtc tttcagcggg cgaatcgcaa 3095701 caatattccc aggtgtacgt ccaaccattc gtcttgcctc ttcgccaacc gccagcactt 3095761 tgccgctgtt tttatcaagt gcaacaacgg aaggttcatt cagaacaatt cctttacctt 3095821 taacatggat cagtacattt gcagtaccga ggtcaatacc aatatccctt gcaaacatct 3095881 atttatatcc tccttgaaaa tctgtttcac agtaaatatc cacattgtgc cctaattata 3095941 tatattatca taaaatatag aaaaaaagtt ggaagcacaa taagttcttt acaaattttt 3096001 gcggatgttt tatgaacgat ttcaagaagg caatgccagg tgattacgat tgctgaacag 3096061 gctctccttc gagaatttca tcttttttat atttgagctt tgtcgcttct cctcctctta 3096121 aatgcctgat ggatttatga taatcgagta tttctttcac ttcgtttgcc aagtcggggt 3096181 taatttcagg cagacgctct gttaaatcct tgtgtactgt acttttggaa acaccaaatt 3096241 ccttcgcaat gacacgaacg gttttctttg tctccacgat gtacttccct atcttgattg 3096301 ttcgctcttt gatgtaatcg tgcacaccac tcgacctccc taaaatggat gtgagaagtg 3096361 tgaaatgaga tccgtattct gtaaagagtc gttcattatg ccgcttcttc gttgtatggt 3096421 tttaaaagta agtttgtgaa atatgcccac gatccctcac ctcaaacact ctctttgtta 3096481 ggtttgtaac agtgtattag cattcttttg ggaatatgct aaaaactcaa taaggacaag 3096541 gggtgaaacg aactttttca gattcagcaa actatttcgc gtcactaaat tttcatcttt 3096601 acaactattg atcgctcctg taaaatgaaa taagcaatta gttacttagg taagtttttt 3096661 agaaggagac cgacatgtcc tacgtcaaca gacacctcat tcatcaaatc aaccaaagcg 3096721 cccgcctgat tgccaagaaa gccaatgaac agctagagcc attcggcctt tattcatctc 3096781 aatggtcagt tttatattgt ttgcgtacga tcggaccaat gactcaaaaa gagatttggt 3096841 cctatttaaa tgtggaagcg ccgactgtga ctcggacgat caaacgcctg gaggagaacg 3096901 gctgggttca gagacggcaa ggtgaagaca aacgggaaaa acttgttgtc ctcacaaaag 3096961 aagccgagaa aaaatacgaa gaaatcaatg tgaaaatgtt gaaattcgag gaagagctgc 3097021 ttgcagattt ccgggatgaa gataaagaag ctttttctca tttattccgc atgtttttac 3097081 aacaatgaaa ataaggaagt gacatacatt tgaaaaaagc ggatgcgata tggaccaagg 3097141 attttattat ggtcctgctt gtcaatttat ttgtgtttgt gttcttttat acatttttaa 3097201 ctgtattgcc gatctataca ctgcaagagc ttggcggcac agaatcacaa ggcgggcttt 3097261 taatcagcct gttccttctg tctgcgatca ttacacggcc tttctccgga gccatcgttg 3097321 agcgtttcgg gaagaaaaga atggcgattg tatcaatggc gctcttcgcc ctatcatctt 3097381 ttctgtatat gccgattcat aacttttccc tgctgctcgg attgcggttc ttccaaggga 3097441 tttggttcag cattttaacg actgttacag gtgcaattgc cgctgatatt attccagcca 3097501 aacggcgcgg tgaagggctt ggatactttg ccatgtctat gaacctcgct atggcgatcg 3097561 ggcctttcct tggcctgaat ttgatgagag tggtaagctt tcctgtattc tttacagcct 3097621 ttgcgctgtt tatggttgcg ggcttacttg tttcgttctt gataaaagtg ccgcaaagta 3097681 aggacagcgg cacgactgta ttccgttttg cgttctcgga tatgtttgaa aagggcgcac 3097741 tcaaaattgc gacggtcggt ttgtttattt ctttctgtta ttcaacagtc acatcatatc 3097801 tgtctgtatt cgccaaatca gttgaccttt cggatatcag cggatatttc tttgtttgtt 3097861 ttgcggtgac aatgatgatt gcacgcccgt tcacagggaa attgttcgac aaagtcggac 3097921 cgggcattgt catttatcca tcaatcctga ttttctctgt cggactctgc atgctgtcct 3097981 tcacacatag cggcttaatg cttctgcttt caggggcggt tatcggtctt ggctacggat 3098041 caatcgttcc ttgcatgcaa acattggcga ttcagaaatc tccggctcac cgctccggtt 3098101 ttgcgacggc aacgttcttt accttctttg acagcggaat tgctgtagga tcgtatgtat 3098161 tcggattgtt tgtagcatct gccggcttct ctgccattta tttaacagcg gggctgttcg 3098221 ttttaattgc tctgcttctc tacacgtgga gccagaaaaa acctgcagag gctgaaggaa 3098281 aagtgtctat tgcagaataa cttgtcagac tgccgggaaa tcccggcagt cttttttcca 3098341 ttaaaacacg gcgccctctc ggttgaacga gagaacgccg cttatagcaa ttattcaatg 3098401 acaggccgcg caggtgaatc aggatctaac gaaaaatcat aggacgcttc atcacgaaac 3098461 atcggatcgg catatatgga ttgttgatcg ttttttgttg cttttcgata cgaagaaaat 3098521 gaatcatatt ctttcttttt ccacatccat atgccgtctt gatccgcttc cttgtggtac 3098581 acgttatgat tgaccgtatt accttcgttt tctgtaaagt cgtttccgat aaataatctg 3098641 gaatcaccgg ccgtcaatat attcttttca attgtgttgt ttttcgtatc gtactgcagc 3098701 agcagctgtc cgccgtacag tccctttgtg tcattccggt acataatatt gcgggcaatc 3098761 agagaattgc tggtgccgcc ccgctttttg tcatatcctc cgattgaaat accggtgtac 3098821 gcattgttgt acactttgtt gtctgtgatc tgaatggcat ttgcatactt tcctttgtgt 3098881 tcagacgttg cttcaatccc aatatcgtta tcgtaaactg tgttgttctt aatttcgata 3098941 tcgtgtcctc catcgacata aatcccgccc gctgagtatt catctccata agcaggattg 3099001 ccgtaagtcg agttttgata aactgtattg ttttctacga ctccgtttcg cacgtaatcg 3099061 tttttatccg cggttccctc ataaccaatt agatcaatcc cgatgttatt attgttgcgg 3099121 accacattgc ctgcaactgt gaagccgtcg atattaccgt tcagcacaac tgcttcactc 3099181 gctccaagcg tcagtttctc aactgtattg tcctcgattc ggatgtcttt catgctgcca 3099241 gtcccataaa ctgcgattcc gtgagcattt ccttcatccg ctgttgtctt aatcccccgg 3099301 atgtgattat ccttaatggc gatatgactg ctggaccctg atacataaat ccctatagca 3099361 gttgcttcct cagatgaaac agaaagatct tgaattgtta aaccgctgat ggcaatgtca 3099421 tgtttatcgt gaatacgaat aagcggtgtt tcatattcag cgttcgcaac ggattcaccg 3099481 ctaatcacga cgttttcatt ttcatagttt cggaatgtga taggctttcc gtccgtaccg 3099541 ctgtgcttta catcaagggt ctcatgatac gtgccctccc gaatcatgac agttgtgccg 3099601 gcagcagcct tctcagatgc gtgtgccaat gtacgaaacg gcttttcttt tgttccttca 3099661 ttttgatcac tgccatttgg cgaaacatac agataatccc cagatccttc ctcattcgct 3099721 tttgtcttat cataaacgaa agcgaggatg acagacgtta aaacacccgc caaaagaata 3099781 aaataccatt ttctcatttt cgattcccat ttcgttttag aatagatttc taaaaccatt 3099841 ataaatgttc tatttatgga aaaccatttc aaaaatatga aaatataccg tctaaataga 3099901 tcttattcag cctggcggac ctgcgcatgt tcaactgttt caattgccaa tgatgcaggc 3099961 gggtgaacac gcatcagaac aatgtagaaa agaaaggaaa tcagcacacc tacaaaccaa 3100021 gaaatatcgt ataagctctt caatacagga acatacatgc caatcagcga aatcagcgct 3100081 cctaacattg tggctgcaaa cgcacggtaa ttgtagccct tccaatacac ataccgtcct 3100141 gtttcggaat acaggtcatc taccgagagc tcacgtttgc gaatgataaa atagtcggcc 3100201 atcatcacgc ctgccaccgg tccaagcatg ccgcctatta agccaagaaa cgcatacacg 3100261 cttgtcgcgc tctccatcag cttccacgga accgtaaata aagcgagcaa cgctgtgata 3100321 aagctgccac gtttgaaatt gatatatttc ggcagggcat tcgctatatc ataagcgggt 3100381 gatacgatat tcgccgcgac atttacagag atcgtggcga tgcagagtgt gatcacggac 3100441 aagacgatga cataagggtt atcaaaccgc gccaaaatat cgacaacatc ccaaatcggc 3100501 tctccgaacg cgacctgcga gccggaggtc accgtaatac ttgcgaatgc gaacagcgca 3100561 aacgttcccg gcaaaccgta aaattgtcct ttgatttgct ctttttgtgt ttcagcaaac 3100621 cgtgtaaaat caggtatatt taagatcaat gtcgcccaga tgccgatgat gccagtaact 3100681 ccggcagcaa acggccagaa tgtttctgaa aacgtatgaa actttcctgg ttgagagtat 3100741 atcgggccca atcctccagc aatatcaacg gcccaccata ccatgccgcc aaataccaga 3100801 tacactaaag gccctgccca cacctcaaaa cgtttaatcg actccatgcc gtgatgcaat 3100861 acgagtaaat gaatggccca aaagaataca aaggaaagca aaccggacaa gtgaatgccg 3100921 agaatgttcc actcgccgcc aatttctccc caacctggcc acatattcaa aagcaaaatg 3100981 ttcagtgccg tgctacccgc aaaggtctgg atgccaagcc acatgatagc tgtaaacgcc 3101041 cttagaagcg cggggatatt cgcgccgtat atcccgtaag aagcccgaat gatcactgga 3101101 aacggcagcc cgtattttgt ccccgcatgg ccgtttaagg caagagcgcc aaataggata 3101161 agtgatgccg taataatgat cgccagcacc tgccaaggcg aaaggccgat cgcaattaat 3101221 cctcccacgg tcgcgtaggt cggtatgtta tgtatacatc ccatccaaat ggaggcaaag 3101281 ttcattgctt tccacgtccg tttttcctgt cccaaaggca ccagatcttc attgctcagc 3101341 ctgttggatt gctgctgact ctcttttaat ttcatagccg gctccccttt ccatattgtc 3101401 tatatgtcgt cacacgttat gttttttgac attagatgtc acttaatata actgaagagt 3101461 cagacaataa cactggctat gatatacaat tttcccgttt gtatttgaac agcttaaaca 3101521 agaaaaagag acagacctca gagcccgtct ctttcttaag atgcagtttt cattaatgca 3101581 gcaaatctca cagccattaa caggcttgct ccgcccgcta taatcataat gattcccatc 3101641 atatcaaaat gggctgccgt gatttcttta ccaaaaagaa tgccaaggat caccgaagac 3101701 aaaatcgatc ctaggtaacg gcaggtttga aacaggcctg aagtcgttcc taccatgttg 3101761 gaaggactcg tttccagcat cgctgcctga agcgcgacat tgcccagtcc gtagcctata 3101821 cccaagagcg acagaatgag gcctttaccg atggtctgga cattgataaa aaagatggtt 3101881 aagagcacgg ctccagccgt catcaaaagc gctcccgcaa agatcggctt gacgacacca 3101941 gatcggtcga tccatttgcc ggttagaggt gacacaacga tgctcattcc agacataaac 3102001 agcataaaca ggccgctcgt ttgaacagaa agatgcattt catcctgaaa gtaacttggc 3102061 aaaccaaaaa ataaacaata gaagaaaaca ttcaataaaa taaactgaac atacacggct 3102121 gacaggtttc gctgtgtttt aaacagacgg acatcaataa acggcttatc cgttttcagc 3102181 tcgcgccaga caaacgcaca gagcagaagc aagccaagca caccttcaac cgcatgcggc 3102241 gacgtgctga acgacagcaa aaaggataga aggaaaatga ttcccccggc aaataaaaca 3102301 attccaagaa tatcgagctg ccgaataatg gttttgattc ctgccccttt tttctgatct 3102361 ttcgggaaca tatacaggcc caataagaag ctgaggataa taaacggcaa attaacgata 3102421 aagatcgccg gccagcctcc ccatacaatc aaaaacccgc cggctgtcgg ccccagcgcc 3102481 gtcatggcgg acgcaaaaat agagagtaca gccaaggctg aagcttggcg ctcatgaata 3102541 tgattccgaa tcaagccgac acctgacgga taaatcgcac tgctccccac cgattgaaac 3102601 agccgcatga ccaataatgt cataaacgtc ggcgcaaacg gcgccccgat ggcagaaacc 3102661 gcaacaagaa taagcccgaa taaaaacaag cgtttccgcc caatcaaatc accgagcttt 3102721 cccgttacgg gctgcgctac ggcactcgcc aagtaaaacg aggaaatcag ccaggaaacc 3102781 gttgtaaacg agaggtgaaa ctcatgctgg atgctatgga gcgcaagaga gatcatagac 3102841 gagttcagcg gattcagcat tgttcccgaa gccacagctg ttaaaaaaac agctcggctt 3102901 tttttcgata acatcatttc acttgttcca gaaactcttc cgttgtccgc gatttaccga 3102961 ttctcgggaa aataaagcgc agtgtggctt catgctcttc atcgctaaat gtggacatgg 3103021 catctgtaat aaaaatctgc tgatagccaa gctgaaatgc ctcccgtgct gtgctttcca 3103081 ccccgatatt cgttgcgatg ccgcacaata caatcgtatc aatgccgcga cgtctcagct 3103141 gcaagtctaa atctgtgcca aaaaaagcac cccattgccg ttttgtcaca gtataatcgc 3103201 catcctgcac accgatttcc ggaacaaatt cggcccagtc cgccggcatt tcccctgaac 3103261 ctccctgcgc aggctcatcc gtttgcggct tcagggcgtc cgctccatca tgaaaggcta 3103321 catttacaaa gctgatgaac ccgttatgtt tccgaaattc atctacgagc tttttcgcgt 3103381 tcgggacaac ctggccgctt tgatcaatcg gcacaattcc cttttgtaaa tcaatgataa 3103441 ccaatgctgt tttttgaaaa tcaatgttga gtgtattcat catacgtctc ctcctgatac 3103501 tgttagtgtt tctcacattg catattttac tcttcacact gcctaagttc ttttatgatg 3103561 cttgtgaaat tctcagaagg agcgttttct catgattttt cttttatgta gtagtaacag 3103621 gttgtgcata cgaacaaacc ggcaagcact gtaatcataa agggcgtcat cgcttcatca 3103681 cctgcctgct gtctatcggt tcctgcctga aaatgcccat gaatttgcgg cggtccatcc 3103741 aaagcaggat aagacacata accattaata tcgtgctaag atcctgcacg ccaatatcaa 3103801 aacaatagtt aatcaagacg atgttcacaa taatgggcat aaaaataacc gcccctaatg 3103861 cagccgttcg cggaatcagt aataaaacag ctgccaggat ttcaccaaaa cctataaaca 3103921 gttcatagac atgagaataa ccgaaaaatg tccacgcgat cgtaaacccc ttcccggcag 3103981 ccgcctcgat ttcaggcgtc acctcgccaa actggccaat taccactttc gccagaccgt 3104041 acacgaaaaa attaaaggct aaaaacaatc ggaacgtcgc gggaatcgac ttgcgtaccg 3104101 ctttcctcag cctgccgcct ttattcatca tacatccccc tcagtgtatt atttgatgta 3104161 gtacacttaa tacagtatag agtattctaa ttaatgtcaa ttcccttttc agctcatatg 3104221 aatagtttct tttatagata caaagtctta tatcgcaaaa aatgccattc tccttccttt 3104281 ccatccctcg ataacatttc tcaaaaacca tgtcaggaaa tcttacatga aaatgtttta 3104341 tcattctttt ttctctataa tgaagaaata taataattgc tttttattct gaaagatacg 3104401 gaggaatgag acatgcaaat gggcgataca gtttttatgt tcttttgcgc tttactcgtg 3104461 tggctgatga ccccgggatt agcgttattt tatggaggaa tggtaaagag caaaaatgtg 3104521 ctgagcactg ccatgcacag tttctcttcc attgccatcg tttccatcgt ttgggtgctg 3104581 ttcggatata cacttgcctt cgcaccaggc aattcaatca tcggcgggct ggagtgggca 3104641 ggcctcaaag gggtcggatt tgatccggga gattacagcg ataccatccc ccactcgtta 3104701 tttatgatgt tccaaatgac gttcgccgtt ctgactacag cgattatttc cggggctttc 3104761 gcagagcgga tgcgattcgg cgcttttctt ttattctcgg ttttatgggc ctctttggtt 3104821 tacacacccg tagcgcactg ggtatggggc ggcggctgga tcggccagct tggagcgctc 3104881 gatttcgctg gcggcaatgt tgttcatatt tcctccgggg tggcaggact tgttcttgcc 3104941 attgtgctcg gcaaacggaa agacggtaca gcgtcttctc cgcataacct catttacacc 3105001 ttcttaggag gagctttgat ttggttcggc tggttcggct ttaacgtcgg cagcgcattg 3105061 accttagatg gtgtggccat gtacgcgttc atcaacacaa acaccgcggc tgcagccggg 3105121 atcgccggct ggatcttagt agaatggatc attaacaaaa aaccgacaat gctcggagcg 3105181 gtatctgggg caatcgccgg gcttgtcgcc attacgccgg ctgccggatt tgtcacaccg 3105241 ttcgcttcca ttattatcgg catcatcggc ggagctgttt gtttctgggg agtattctcg 3105301 cttaaaaaga aattcggata cgacgacgcg cttgacgcct ttggcctgca cgggatcggc 3105361 ggcacatggg gcggaatcgc aacaggatta ttcgcaacaa cctctgttaa ctcagcgggc 3105421 gcagatgggt tattttacgg tgatgcaagc ttaatctgga aacaaatcgt cgccatcgcc 3105481 gccacttatg tttttgtatt tattgtcact ttcgttatta ttaaaattgt aagcctcttc 3105541 cttccccttc gcgcaactga agaagaagag tcacttgggc ttgacttaac gatgcacggg 3105601 gaaaaagcat atcaagattc tatgtgagga gtgacgctat gagcggtcaa atgttcaagg 3105661 tagaaattgt aacgcgtccg gcaaattttg aaaagctgaa gcaggaactc ggaaaaatcg 3105721 gagtgacctc tctgactttc tccaatgtac acggctgcgg ccttcaaaaa gcacatacgg 3105781 agctctatcg aggggtaaaa atagaaagca atgtatacga gcgtttaaaa atagaaattg 3105841 tggtcagcaa ggttcctgtt gatcaagtga cagagaccgc taaaagggtg ctgaaaacgg 3105901 gatcaccagg tgacggtaaa atatttgtct atgaaatcag caatacgatc aacatccgca 3105961 caggcgaaga aggacctgaa gcactttaat atcggtacga gattcggaca ctccggatct 3106021 ctttttttgt gcacagaatc cccccagaaa ccgcgattcc tcttcgaatt ctcttcaagc 3106081 gccgttattt cagacaatct ctatttttat ttgaaacttt tcatgagtaa gattagtcta 3106141 ctaaatataa aaatgtaaaa ggtgattatt tgaactacga aatttttaaa gcaatccatg 3106201 gactatctca tcacaattca gttctcgatt ccattatggt cttcatcacg gaatatgcca 3106261 ttgtcgccta tgcccttatc ctattggcaa tctggctgtt tgggaacaca caaagcagaa 3106321 aacatgtgct atacgcaggc atcacaggaa ttgcaggcct tgtgatcaac tatttgatta 3106381 cgcttgttta tttcgaaccg cgcccgttcg ttgcgcatac agtgcataca ctgattccgc 3106441 atgctgcgga tgcttcattt ccaagtgacc atacgacagg tgcattagcg atttctattg 3106501 cgatgctttt cagaaaccgc aaaatcggct ggccgcttgt catttttggg cttttgacag 3106561 gcttttcgag aatttgggtg ggacatcact atccggtaga tgtattgggc agcctcgttg 3106621 tcgccatcat tatcgggttc cttttcttta gattttcaga tctgcttcgc ccgttcgtcg 3106681 atttggtcgt gaggatctac gaagccatta tcaataaact gacgaaaaaa ccaaccgatc 3106741 aaaatttcta agaaagacaa aagccggcgt ctgaaatcaa gacagccggc tttaatattt 3106801 ctcatacatc tcttgttttc ttcgcttcgc caacacatat aaaccataaa acaacccaat 3106861 tccaacagca tcgatgagca catcccggat acaaccattc ctgctgaaga agagctgaag 3106921 aacttctgtg aaaaaagcaa acgcaaatga gccggctgca gctgatctta tgctgccccg 3106981 ctgtttccac agcaaatatg tcagcacaaa gaaggaaaac gcgtgtccga ttttttgaat 3107041 aaacgcttca ggtacagtaa gctcagtaaa atccataact aaaaattgag acagatcagg 3107101 gtgcggctga aaatgaaaag ccaccgtttg cgatacgacc atgccgctga agctttccgt 3107161 acagacagaa agcaggataa aaaagatcca gcctgcgagc aataggcggt tcatgacata 3107221 acctccttta taacgtacgt gcctacatgt aactacatag acggtaaaac aaagcaaaaa 3107281 gtaacagaaa aaaacgccca tcacaaggat agacgttttc ttcattaaga ctgttcagtg 3107341 tcttctgttg tgctgctttc tttagaacca gatttgtcag ttgaatcatc ctttttctca 3107401 ccggattttt cttctgttcc tttttcagtt gatccgtcct ttttctcgga agattgctga 3107461 atggattctt ctgtttcttg ggtggcagct ttttcaatag aagaaactgg tttgtccata 3107521 aagtttaacg gattcattgc aaccccatct ttacggattt caaagtgcac gtggtttccg 3107581 ctgtcttcac tgtaaaggtt cttgccagat tttccgatca cttgattttg ttttactttg 3107641 tcaccttgct ctacgcttac ttcggaaaga gattgataca cagtcgataa accgtcggca 3107701 tgttctactt ccacaacata tcccagcact ggatcttttt cagctttaac aaccgtaccg 3107761 ctcagagaag cagagacatc gaaatctttt ccgtctttct cagctaagtc aattcctttg 3107821 cttaggctgt acgtgttatt ataggtaacg agtgctgctt ctttctcttc ttttgcggca 3107881 tcggtttcat agaacttttt cacaacagaa acgttttcag aatcaacaac cggcattgcg 3107941 acattttcca ttgactttcc tacttcaact gcatcgtcgt tgttgtcata tgcggagttt 3108001 ccgccgttat cagccaactg atcctttacc tcatcatttg atactgattg ataccaaagg 3108061 acagctgtta aaatgacggc cgcactgact aagtaaattg cagggaacac ccagcgttta 3108121 cgaaaaaact gctgaagttt tttgacttga gaagttttct tttcttcctc tctcattgtt 3108181 tcatcacctc agcaacattc tgaacacttt tctgaaaata tatacaacct atccaaaaaa 3108241 acttttttag atgtagtttg cacagactga acgaaaatat gtattttttt gagaggagtg 3108301 ccaaaaacgt atgaacatga cattgcgtct tgctgaacat agagacttgg aggctgttgt 3108361 ggcgatttat aattcaacga ttgcttctcg aatggtaaca gccgataccg aaccggtaac 3108421 tcctgaagac cggatggaat ggttttcggg acatacagag tcacgtccgc tctatgtggc 3108481 cgaggatgaa aacggaaacg tcgctgcctg gatcagcttt gaaacatttt atggaaggcc 3108541 agcctataat aaaacagcgg aagtcagcat atacattgac gaagcatgcc gcggcaaagg 3108601 tgttggatca tatttgcttc aagaagcgct ccgcattgcc ccgaatcttg gcatccgctc 3108661 acttatggcc ttcattttcg ggcataataa accaagcctg aagctgtttg aaaagcacgg 3108721 gtttgcagaa tggggactat tccccggcat cgccgaaatg gacgggaaaa gatacgattt 3108781 aaaaatttta gggagagagc tttcatgatt agtctggata aagatgaaaa cgaaattgaa 3108841 catcataatg aagaaaatag ccttgttgaa caggagactg cacctgttgg acaggagagc 3108901 cgccagctga gcgcctccgc tgtcaagtcg ctatccgaca ttgccaagtg gggcaaaatt 3108961 tctggcatct tgttaatcat tatgggatcg cttgtcactc tgtctgtttt gatgacagtg 3109021 attggcgcca tcccgggcgt actgctcatt atttcaggcg tatttttgat gcgctcagca 3109081 aaagcagccg cggaagccga aggaaatcta accggcagcg ctggcgaaag catgcttgaa 3109141 aattacggga catttataaa aatgcagctg ttttatgcag catccagtat cgttactgtc 3109201 ctgatcggga tcattgtagc cattttcgtg ctggtggtaa tcggcattgc tgcttttgag 3109261 aacacgcctt cgtatgatga tccggattct tattattatg aggatgatcc ggtgtttgaa 3109321 taatgatgag acaggacagg gcatgagttc catataaacg gaaccatgcc tattttattt 3109381 gactattcaa agcaggccgg cgtaaacacc aaatcctgaa gcaagcatac aatagacatc 3109441 tctagtagag gaaatcaaca aagcaacgct gttacccaga aatgaatatc aaaaaaacgg 3109501 atgaagtcgg aatcaatccg aaaccgcact ttttatttcg ggtgtctgca tgcaaaaaaa 3109561 cacacccgga tcgtctggaa aatctcaaca atccgggtgc agatcttctt taatacattt 3109621 ttttgcgtct gtcttcctca gtcaaaaatt caacaaaact ccgcatcgca aaaggctctt 3109681 cctttatttg tcgtgcgtag gagcttttcc gctcttctga aaggatttcg ctctttttga 3109741 tcctgttcag catatagatg tgaaccgttt tttggatttg tttatgctga tagcctgcct 3109801 ctttaaaaaa tgcgagcccg agcgccgcca aaagggcgaa tatgcctgcg ctgatcaggg 3109861 actccctgtc agctgaagca tgaaatagaa aagcagctaa attaaagaga gagaatgcag 3109921 caagcggaat agcaagaaaa cggtaaatga cggttttttt catgaaaggc tgtacggcct 3109981 tttgaatttt ttgcatttct gttttgatga accccggcat ttgttcgact ctgtaaaagt 3110041 tcatataatc ctcccccttt atttgatgtt tcaagcttca cgaacgttat catatgtgtt 3110101 tattttaacg caggtgcaag ctggttttaa agaaatctgc ccgtattttt cacgaagaat 3110161 ctggatcgcc gctctttatt cttttaaaat gtgagtgtta taatttgtaa tgggaatcag 3110221 atcactgtta ttcatggaat actaatggca atcttcttga taaatatgaa tgagcggggt 3110281 tacaaagtga gtatttcttc catcctttta tcactttttt tcattttaaa tattcttttg 3110341 gccatcattg tcatcttcaa agaacggcgc gatgccagtg catcttgggc gtggctgctt 3110401 gttcttttct ttattcccgt tttaggcttt attttatact tattattcgg ccataatctc 3110461 agacgcaagc atttgtttca atgggaagac cggaaaaaga ttggaattga aaggctgctg 3110521 aagcatcagc ttgaagattt agaaaccaag caatttcagt ttaacaaccg ggcaaccttt 3110581 gataacaaag atttaattta tatgctgatt atgaataacc atgctgtgtt tacagaggat 3110641 aattcagttg acgtcattac agatggacgg gataaatttc agcggctgct gagtgacatt 3110701 tcaaaggcta aggatcatat ccatttacag tattatattt ataaaggcga tgaattaggc 3110761 aaaaaattgc gggacgctct catccaaaag gcgaaagaag gtgttcaggt cagagtgctt 3110821 tatgatgaac tcgggtccag aacgctgaga aaaaagtttt ttaaagagct tcgcgaggct 3110881 ggcgggcatg tggaggtctt tttcccgtca aagctcaggc cgattaacct gcggctgaat 3110941 taccggaacc atcgaaagct tgtgatcata gacggtatga ccggttatgt cggaggcttt 3111001 aacgtcggag atgagtatct agggcttaat ccgaaattcg gttattggcg ggatacgcat 3111061 atccggctgc aaggaacggc cgtgcacgcc atccaaacac gattcatcct tgactggaac 3111121 caagcttctc atcaccatac gctgacatat attccaaatc actttcctga ttacggccca 3111181 aaaggcaacg tcgggatgca gattgtcaca agcggccctg attcggaatg ggaacaaatt 3111241 aaaaatggct acatcaaaat gatttcgaac gccaagcgtt ccattttgat acaaacacct 3111301 tattttatcc cagatgcaag cctgctggat gctttaagga tcgcttgcct ttcgggcatt 3111361 gacgttaaca ttatgattcc gaacaagccc gatcacgcct ttgtatactg ggcgacactt 3111421 tcgtatatcg gcgatctgct gaaagccgga gccactgtct atatttacga taacggcttt 3111481 attcacgcga aaaccatcgt ggtggatgac gaaatcgctt cagtcggcac agcgaacatt 3111541 gatgtccgaa gcttcaggct gaattttgag gttaatgcat ttatttacga tatcaccatt 3111601 gctaaaaaac tggtttcaac ttttaaagaa gatttgctag tatccagaaa attcacctat 3111661 gaggagtatc tgcagcgccc gttgtggatt cgaataaaag aatccgtctc gcggctgttg 3111721 tcgccgatct tataagatgc gtaaaccccc ggcctttacg gccgggggtt ttcctgatgg 3111781 tcacagtaaa tgatgattgc ctcccgcaaa aaagcggcaa gaccttctcc atattgattg 3111841 attgaatcgg taaatcgctc gtcagtgata tacacttccc cgagtcctct gaaaatgtcg 3111901 agtgtgcaat cgtaatgata ttggcaaata tgatcgcgaa atgcccccac agcggcctga 3111961 atctctgcat catcgggccc atgcttcatt cgcgccgcaa ttcgtctgta aatcgaatca 3112021 aattcagcca tgatcgtgcg ccaatcatct gccgagtatg cagatgtcct tttctctgtt 3112081 tcttctgcga tttcctttcc atacagcttt ctgacttcat cagcgtatgt ctgctggtgc 3112141 tcttcaatgt ctttcatgct taatccggca aataaatccc tcttattcat cgtttcccct 3112201 ccatcaacgg acaaaagcgt cctgtcaatt gtttgaatca tctcatccat tctttgtttt 3112261 ttcttcatca atatctcctt ttgcgactga agtgccgctt tccggtcaaa attcggatga 3112321 tccagcatct ctttaatctc atccagacga aacccgattt ccttgaaaaa taaaatctgt 3112381 tgcagtcttt ccaggtctgc gtcactgtac aaacgatacc cagcatcagt aagcgctgaa 3112441 ggattcagaa gctcaatatt gtcatagtga tgaagcgtcc gaatgctaac gcctgatatc 3112501 tccgccactt gtttaacttg atatttcata cataacacct cctctttttt atcgtaaaca 3112561 atcacgcaac gttagggtca atccccaaaa tgttattttc tatatacaaa acttctcaca 3112621 aatagtgtat aaaagaaaag tgagtatttt tttgtaaagg ggagccagta tacatgaatc 3112681 ctgaaacaat gaacaaaacc ctcatcagca tttcgaaatg gggaaaagct acaggcattt 3112741 tatttattat tatgggcgca attaccgcgc tttcaggcgc gttctttttt ctaatcggtg 3112801 ccgtgccagg cgtactgcaa attatttccg gtatcttttt gatgaggtca gctagggaag 3112861 caggccaaat ggctgaacac aatagcggac agtctgaaga cttaatgctg gagaattacg 3112921 cgaaattcgt aaagatgcaa gggatttatt tgatcgtaag cattgctgta tccattcttg 3112981 cgattatcgc cttcttcatc tttttaatgc ttgggattgc tgacggcctt ttcagcgata 3113041 cgtacagcac ttattaatga gaaaaacccg gagctggctc cgggtttttt attattccgc 3113101 ttcgcttacc actgtgaagc gttcattttt gtgttcggga tgttcaagct cgtccaacac 3113161 ggcaatggca taatctgcat agctgatata gctgtctcct tttgcattta cgatgacatt 3113221 gtcttttcct ttttggtaag agccagtccg ttttcctgct ggatcaaaaa atgccgcagg 3113281 actgaggaac gtccaggaaa tggagtctgt ctgctgcaaa tctttcaggt tctcgccttg 3113341 atttgatgca gttggcaaat attctttcgg aaattccggc gtatccatta aacgggttgt 3113401 tttggcttca tcaacaaaca ggcttcccgc tccgccaaca acaagcaatc ttgtgtgctt 3113461 cgcgtccttt aaaatgctga tgagtgctct tcctgcttca acatgaagat gttcttggcc 3113521 gggtgctgct ccaaaagcgt ttacgaccgc gtcgaaaggc ttgatgtctt ccgcagtcag 3113581 ttcaaacaca tctttttcca aaatcgctac gtcttgctcc tgcacttttg aagcgtttct 3113641 gacgatggct gtcacttcat ggcctctttt tttcgcttct ttcaaaatct cgtttcccgc 3113701 tttcccgctt gcgcctataa taccaatttt catttttcat ttcctcctta tttgtaacaa 3113761 ttttagttac atgttagcgg tgagaagtca tcccttttga ttaaaagaga tgattcataa 3113821 catcttttaa tgacttgctt gccagttcat tttccatcgc tctttgcaca ctttcaaacg 3113881 tttcatccag agcgttctga atttttttcc ctaccggaca tttcggattc gggttttcat 3113941 gaaccgcaaa gagttcttct tgcttttgga cagcccggta cacttctaaa agagaaatat 3114001 cagcaggatc ttttttgagg cttgcacccg gcaccccggc gcgtgatgtg agaatatcag 3114061 cttttttcag caggctgatc attcttcgca caactaccgg attcgtgttg acactgtctg 3114121 caatgatttc tgaagatgtt ttttcatcca tcgagatgag ggataaaata tgaatggcaa 3114181 cagcaagacg gctgttaatc atgttttttc accaccgttg taactataat agttacattt 3114241 gattcgtttg tcaacatcta atatacacta aatacatggg ttttgtgcac cgtttttagt 3114301 caatagaacg gccggatgca ctccggccgc gtcttatcaa aataagaaat atctttgtcc 3114361 aagtgggaca taatcgacag gctggcaaga caattcctcc ccgtcagcaa agacctgata 3114421 ggtttttgga tcaatctcaa tcttcggcaa agccgaattc agcttcatat ccagcttgct 3114481 cagctttctg atatttttga ctggagaaat ccttttttcc agccctaagc tttccgccac 3114541 accacgctct atgcttgcct gagacataaa tgtaatcgag gttgagcggt tggcttttcc 3114601 gtaagacgca tacatttggc gcatgaaaac cggttcagga gtcgggatgg acgcgttcgg 3114661 atctcccatt tgcgcacgtg caatcatgcc gccctttaag accagttccg gtttcacgcc 3114721 gaaaaatacc gggtcccaca gaacgagatc agcaagcttc cctttttcca ccgagccgac 3114781 ctcatggctg agcccgtgcg taattgccgg attaatcgtg tatttggcaa tgtaccgttt 3114841 tgcgcgcaca ttgtcattcc cgttttcacc ggcaagagcg ccgcgctgtt ttttcatttt 3114901 atcggctacc tgccatgttc ggatgatcac ttcaccgacc cgccccatcg cttgggaatc 3114961 cgatgatgtc atgctgatcg cacctatatc atggagaata tcctccgcgg caatcgtcgc 3115021 cgccctgatt ctggaatggc tgaatgccac atcttcaggc actttcgcat ctaaatggtg 3115081 gcagaccatc atcatgtcaa gatgctcatc catcgtatta acggtataag gaatggttgg 3115141 cgttgtagat gacggcagaa tgttcgcgta agaggcgagc ttcataatat ccggagcgtg 3115201 accgccgcct gccccttcaa tgtgataagt atgaataacc cggtccccga tcgcgtcgag 3115261 cgtgttttcc aaaaagcccg cttcgttaat cgtatcggta tggatggcaa cttgaatatc 3115321 agcctcgtcc acgacttcca tacacgtttt aatggcgctt ggcgtcgttc cccagtcttc 3115381 atggagctta agaccgatgg cgcctgcttc cacctgctcg atcagcggcg ctttatcgga 3115441 tgcattccct tttcctaaga agccgacatt gatcggaaac tcctcggccg cttccagcat 3115501 cctcgccata taccacgccc cggacgtaca tgttgtcgct ttgcttcctg tagcgggtcc 3115561 tgttccgcct cccaaaaggg tcgtcacacc tgaagaaagc gcaacttcca tctgctgagg 3115621 acaaataaaa tgaatgtgcg tgtccactcc cccggctgtt aaaattttgc cttcaccgga 3115681 aatcacctct gtccccgctc cgatgaccat gtgcggatcg actccatcca tgatatcagg 3115741 atttccgctt tttccgacac cgacaatccg gccgtctttc acaccgacat ccgctttgac 3115801 aatgcctgtg taatccaata gcacgacgtt ggtgataacc aaatccaaag cgccgtcctt 3115861 ccctgtgatt ctgccgtttt ggcccatgcc gtctcggata gtttttccgc cgccaaagat 3115921 catttcttca ccgtatactg tgaaatcctt ttcgacttcg atccataaat ccgtgtcgcc 3115981 caatctgatt ttatcgcccg ttgtcgggcc aaacagttcc gcatattcct cccgtgacat 3116041 tttcatcgga ttacaccctc catccagccg gcttgtttta agttggccaa cgttttttct 3116101 ttgccgcgtt catcgataaa cgtgtcggcc attccgttca gccctctaat tgtcttgcgt 3116161 cctctgattt ccactagtga gaccgttttc tgctctcccg gctcaaaacg gaccgacgtg 3116221 cctgatggaa catcaagacg catgccgatc gccagctcac ggtcaaataa taaagccccg 3116281 ttggcctccg caaaatgaaa atgcgaaccg acttgaatgg agcgtgatcc ggtgtttttt 3116341 accgttacct cccgtatctc acggccttca ttaatcgtaa tggttccctc agcaatttga 3116401 aatgctcccg gcttcatgac ttcacctccg cagaaattgg ctgatgtacc gtaacaagct 3116461 ttacaccatc cggaaatgtg gcctccacct gaatgctgtc cagcatctca ggcacaccct 3116521 ccatcacatc tttttccgtt aatacatggc ggccggcttc catcagctct gctactccct 3116581 tcccatcacg tgcgccttcc ataataaagc aggtgatata agcagcagcc tcaggatagt 3116641 tcagcagaac gccccgcgcc tttcgctgtt tggctaattc ccccgctgca aaaatgagca 3116701 atttctcttg ttcaactggt gtcagtttca tctgtagtcc tccttctttt gtcatataaa 3116761 gcagatgcgg ctactacgaa tttgcggaac agtcaggcgg gacatcacct ccctttcttc 3116821 gagaatgggg gtcatacggt aagatgcctt tcaaagcggc atgccgtttc ttcatcagcc 3116881 ttgccatggt caacaaccgt tcccctgtcg atcacggaaa gatcagatta acgcgttttc 3116941 cagactgcgc tcgactaaga taacaaatgt ctttttttct ggaaatttct ataataactt 3117001 gtctgactag ttcgacaatt aaaatctgaa ttccttccaa ttgtttatta agtaaaatat 3117061 ttttcagatt taccatcagc gctctggtga ttgcaagctg ctgctgttga ccgccttttc 3117121 gttttgaaca aacgtttgat taaaacaaat agccccctct gtttagccgg agtcggccta 3117181 atacagcgac aatctgcccc gggcgaagct aaggctgtgc aaaaccatcg attgatcata 3117241 accagacgtt acattcctga tggcagcccg ttgttttgct ccgcaaccgg aagcatggca 3117301 tggaggccag tctgaggcgc cgacctccac gataccgaga acccgactat tgccattaac 3117361 tccgcatcat ggacggtcac ttcgctgatc gccaccgttc ctcttaatga gtgaagaatt 3117421 ccggccttca ctgaatcccc gcttgtgtcg atatcaactg ttttctcgca ctcccgtggc 3117481 ttccgacact ttcttcggtg cagtacattc cgtcatcaaa acccctttgt ttgatttctt 3117541 caaatgatgt tataaaagtt tacaacttat gtcatcatta tatagaagag gcctattaat 3117601 tcaaagaata tttaaaaaat ttagttacct tgaccaaatc agcttctttt tttgttatat 3117661 ttattcacat cagaaaaagc gaaaaaaaaa gacaagaaac atttcgtttc ctgcctcttc 3117721 cgtacgatta atctttatct gaaaatttat ccttggcttt cccgatatcc ttttggattt 3117781 cgccttttgc cttatctttt ttgccttcag cctgcatgtc cgttctgtca gccatatctc 3117841 cgactttatc cttcacttct cctttggctt tattgaagcc gcccttcatt ttgtctttta 3117901 cactatcgtt acccatgtta attctcccct ctcaattatg tgtgtacttg ttaacttccc 3117961 gatctgagag gcaataaaca ttctaatgtt atttatcgat ttcgtagcgc tctccgtaac 3118021 ggagcacctt gtatatcgcc agcccgtctg atgacttttt ctccgaatat cggaccggca 3118081 gcagggcaaa aaacacataa tacgtagaaa aatagacaaa ctgatagaaa aacacattcg 3118141 gctttaatac actgtgtata atcagcagat tgattgcaaa aatcgtgatg aggttaaaca 3118201 agcagccccc tgcatacacg agtgcatttg agaatcgatt gtcaattttc aactccccgt 3118261 accggcaaaa agaatcgata aaataaatcg ttctgaaccg tatgggtcca attttaagca 3118321 gcgtttttcc catgcctata tccaacgatc cctttccgcc aaaaataaaa gccataaagc 3118381 tgtgccctga aacatgtata atctgtacaa gcggcagaac aatgaggaaa gaccacagaa 3118441 acttcaccat atcattaaaa ccaaacattg aattccccct cacatgcata tctgcatccc 3118501 aaaacggctt ttgttcaaaa aacagtgctg tagcgatttt tcctgttctc cccggaaata 3118561 aacgttccga tgctcccctt tttttgcata aaaaaaaacc atctgccagc agatggtttt 3118621 gtctcatact tcatataaac aatcgttcct ttgaatcatc tctctcatgc tgaccgcttt 3118681 ttcataaaaa tacaccgctt ctttatattg ttcgcgatga ctgaaataag aggcagcatc 3118741 taaagcaaat tcttcaatat atacatacag gcccttttct tccatataat caaatacttc 3118801 ttgaatcata ttcaaattga cagattccac atataatgcc tgcagaaatt tatattttgc 3118861 cagactgaag aagtcgtttc gtttttgggc aatggcaatc cctttttcat agtaccgtat 3118921 cgcggcttcg ctatcttgtt ttttgaaaag aacgcgagtc aggctgaaga gcgcttttgg 3118981 aagctgttcc agctgataat cctcgaagac aggaagcgct ttttcaaagt attcggcggc 3119041 ctgatccagc tcccccttgt catcatagca attaccaata ttataaaggg ctgatccgat 3119101 caaacggggc tgtccttcca ataaagcaag gcgatacgcg tcatctaaat gttcaagcgc 3119161 tttttcataa tttctgtagt caatgtagtt tcctgatatg acgaaatggc attgaattct 3119221 tctgactctg taaaaatcgt gagccttata cgtctccagc gcctgtacgg catggttcat 3119281 ggaaaagtgc gtctgcttca taatataaaa gacttccgcc actttaaaat gaaattccgc 3119341 tctttcaatt tcatcttcta caaacgcaag catcttctca gctttccgat aaaaggatat 3119401 agccgagatg taattgttct gttcaaattc gtacattcct ctaaacaagt gaaaataata 3119461 ctcagataat ccggagatgc tgtcctgatt gctttccagc gttttgatca attcacgata 3119521 ttgaagctga gattcctcgt gcaggtcagg ctttacataa tccagcataa tttggtgccg 3119581 gtagctgatc agctgataat acaggagaag cagctgatcc tcttccatct gttcgatatc 3119641 tagatcaatt tcttctttca gttttacggc atcagccact tgaaatgcta aaatgtgctt 3119701 ataccactta ttgattttca ctcctacttg agatgacggg atctcgtacg cggccatgcc 3119761 cctccaaccc tttctatttt ctaattggtt atattttatc ataatgtatg gctttggaat 3119821 taaattttct tacaatgatt ccttctttat gcctatcctt atatatttcg gtttttctac 3119881 gtattttttg cactcggatt ctaataaaaa agcttaccgg acagtgccga taagcttttg 3119941 acttcaaatt aaccgccaat ataagacatt tccactttct ttttgccaga tgcttttgat 3120001 agcgtacgat cgactgaata ctgatcgatc cgatttttcc atactgtccc gatcatttct 3120061 gatagttcgt catcacttaa ttcctggcga accggagctc tgaggtcaaa tccgcttgaa 3120121 gcgaataagc aggtaaacag ctctcctctc gcagaaagac gggctctgtt gcaagatccg 3120181 cagaatgcat cagatacaga tgatatgacg ccaatttctc cggagccgtc caagtagcgg 3120241 aatctggaag ccacttcgcc tatataatta ggcgctatcg gctcaaccgg catgtgttta 3120301 ttgatcaaat ctatgatttc cgcctttgtc atgacgtctt tcttttccca ttggttggtg 3120361 ttgcctacgt ccataaattc aatgaatctc aggatatgcc ctttttcttt aaaataacgg 3120421 gccataggca gtatatcttt ttcattgacg cccttttgaa cgaccatatt gattttaaca 3120481 ccgagccccg cttgcttcgc cgcttcaatg ccttccagca ccttgctgac agaaacaccg 3120541 cgcccgttta tcttcttaaa acgctcgtct tctaaagaat caaggctgat cgtaaccctt 3120601 ttcagcccag cctccttgag cctcttagca taaacaggca gcagtgatcc gtttgtcgtc 3120661 atcgcgatgt cacgaatacc cggtatgcgg gccagttttt tgattaattc cggcatatcc 3120721 tttctcatga ggggctctcc gccggtcaag cggatttttt caacgccaaa tcttgtgaca 3120781 aacaatgtcg caagccgttc cagctcctca aatgaaagca gctcctcttt ctttaaaaaa 3120841 ggataatccg ggccgaataa ttcggcgggc atacagtacg tgcatcggaa gttgcagcgg 3120901 tctgtaacag aaatgcgaag gtctctcagc ggtctgtttc ttttatccaa catctgacgc 3120961 gactctgtaa tcatagctac agccccttcc tactccctga ttctctcagg gtgtgtatat 3121021 acattaaatg atccgtttct gacaaatcca atcgctgtga tattcaattc ttcagccatt 3121081 tgaatcgcaa gctccgtcgg ggccgatttg gaaatgacaa tcgacacgcc gattttggcc 3121141 gcttttaaca ggacctctga tgagattctg ccgctgaaca caatcagttt gtcgcgtacg 3121201 gacatcccgt ttagaaggca gtgtccgtat agtttatcaa gtgcgttgtg ccgaccgata 3121261 tctgtgcgca tcaacagaag cttctctgtg tcgcaaagcg ccgcattatg gacgcctccc 3121321 gtatcctgaa acgtcccgct cccttgctgc atgtctttca taagcgccag acatgcctca 3121381 ggcgatatct tgatttggct gacagccgtc ttggctgttt tgacatcctg ctgaaaataa 3121441 aaatgacggc cctttccgca gcatgagccg atcacccgtt tcgtataatc cttttgatcc 3121501 aatgtctcag ggtgaacgag gtcgacatat acaaaaccga gactttcatc tattgtaaac 3121561 cttttaattt ctttttgaaa tcgtataaca ccctctgatg cgagaaatcc gatgacaagc 3121621 tcttcgatat gctcaggcgt acaaacgagc gtcacaaatt cactgccatt cagtatcact 3121681 gtcaaaggga attccgtcac catccggtct tctactttgc ttatttcccc ttgttcatag 3121741 cgccatacat ccctgaccgc agttacttta tcgttcaatg tctcttcccc tccgcaatgt 3121801 tcctgccttt atattttttc acactcctcg gattttgtcg aattctgaga cacaaaaaga 3121861 gccctctata taaagggctt ttacaggatg tgatgacggc ggtgtttagg caggacgcct 3121921 aagcatttag ccgccgttcc ttttataaca cgtgagcacc aatgtgcatt gacaacgaac 3121981 gcggggtttg tcgacacgct gagacacctc tgtataaagg actctatgtt tgattatgct 3122041 gattcttttt cagaaccgta aacagcacaa tagctgcgat caaggtgaga atgctgacaa 3122101 aaaagaaggc tgccagtttt agaagaacac caagcaatat aaatgcaacg gtggctataa 3122161 gaaaaatcat tccgaataat ttcatatgtt caaccccttt ttagggtatc attcccgccc 3122221 aaactgtttt taaaccaata aaaaaggcgc ctgggggagc gcctgatctt taggttcctt 3122281 actcagtaaa tttttgtgct tctttttccc aagcctgttc gaactcatcc gcactgttcg 3122341 ctgaaatata ttctccgccg ccagcgacag ctgcttgttt catctcttca ttacccttga 3122401 catcaaagtt gaagccaatg atgtttacaa tcgtatccac atttgatgca cggagctttt 3122461 cgatttccgc cgcagggtct ccgccgcacg tttcttcacc gtcagtgatt aaatacacca 3122521 cgtttttccc gtctgcgtca aatgcttcaa attcttttct tgtgtctgca agtgctttgg 3122581 caatcggtgt ccatccagtc ggcttgagct cactcaatga attgtcaaac agagaccctt 3122641 catatggatg aaggccgtaa atggtttccg tcgtactgca cgaaagggct ttaccggaca 3122701 gtttattgtt ccctgcatgc ccgaaaacgc gaagcataag atttgtatcc tttggaagaa 3122761 gttcggcaaa agattttact gattttttgg caatgtctat tttgcgctct cctcctgttt 3122821 tttgaaccat gcttccgctt ccgtcaaaca aaacagctac atttgtatca gcctgtttct 3122881 cagcggcaaa agacggggag gcaatggaaa cagtcaacaa tccaatgata ccggcagcca 3122941 gcaatttttt catatgatta cttcctttct ttttcatatt ttccaactat atgttggatt 3123001 cttctttatg ctagaatacg aaaatgcaaa aagatatagg acatgctgcc ttttgtgctg 3123061 ctttcacgat ctgtccaaaa tcgcttgaaa tgccgttcat ttttagccat ttccgcccag 3123121 aaagcataaa cagcttgtgt gatcattcat tcttttttcg ccttgattat gacagaaaaa 3123181 cggaaatctg ctactatgct acaggcagac agctaattag ttttgaagtt tttgttacat 3123241 acaaaaagag gctgaccatc accagcctct tttttcttat ttagataaca ttagtgattg 3123301 ctgagtgaaa attttctcaa catctttttg ggtataagcc gggaagtatt caccgccgcc 3123361 tactttcgca attgcgttca gctggccttt gtatccctct ttataatcaa agccgatcac 3123421 attaacagtg atattgtctt tttgcagttc ctttgctgtt ttaatcgggt ttcctccgca 3123481 cgtttcctca ccgtctgtca acagatacac cactttttcc ccttttgcat caagctggtc 3123541 aaaagaagat ttcgcctcgt tcagcgcttt ggcaattggc gtccagccag tcggcccaat 3123601 tgtattgaga gaattgagga agctttgctc gttaaagctt tggaagccgt atacgttgcg 3123661 aatggcttca catgactgaa cttttccgga atttttattg tttccttcag agccaaacac 3123721 gctcattttc acctgagttc cttctggcaa tgagctcgca aactttgaaa tttctttttt 3123781 ggctgaatta aatttagata caccatctat tcttttcgcc atacttccgc tggcatcaag 3123841 caagaccgcc acgttcgccg gcgctttagc ctccgtttct gtcttttcag ctgcaaaagc 3123901 aggtgaagtt aatccaaaaa gcaatcctgt catcatgatc agtgaaaatc ttttcttcat 3123961 gttcgtaccc ctttaccaat ttgtttctgc gtgcagatgt tcaacgctga acataatcta 3124021 tcgtaatcaa caaaaaccga gaaataaata gggcgggctt ccccattgct gttgtttact 3124081 tttgcataga aacctatgtt tttattagtg atttccacct aacgccccta tgaaaagaga 3124141 agattgtccg cctttcggct ttcgttatat gagtctgtcg aagtctgtcg acaaatgtgg 3124201 atgactttac cacaatctca aagcctgaaa tcaggaaaaa aggactgatc cttaaagacg 3124261 gtcagaagct cctctaaacc gtttcagcta ctcttagata aaagatattc aggaacagaa 3124321 aaagacgccc aatgagcgtc tttttctact ttttcgccat atatttattc aaaaacgcat 3124381 ctgcctcaga aatttgtgtg ccttggtaat agtactttac aatgtcatca accgttttgc 3124441 cttctttggc cataaaattc gctccgtatt ggctcatccc cacaccgtgg ccaaatcctc 3124501 tcgtcgtgac tgtaattgtg tctccatttc gcttccattc aaaatcggcg gagttgagac 3124561 ccaacttttc acgtatgtct cttcctttca gcgtcttgcc gttaatgacg gcagttgcga 3124621 cctggtggcc cggtgtctcg ccggtaatct tccctactgc gctagatcca tccagcttga 3124681 cgccaagctt ttgctgaaat tctgccgctg taaaggtttt cgttgcctta tatttcggag 3124741 actttttatc ccatgggctt ttgacgcttt ttaaatatgg gatagcactt gtccaataag 3124801 cttctgcatt ctctgtgtag ccgttgcttg tggagaaaaa ggatgcttca atcggctggt 3124861 tgttgtacgt taagattttg ccttgcgtac tggctaccgc atctgtgatt ttcttcagtt 3124921 ttgtctcata gcttgtgccc cactgttttt tcagctccgc tttgctttta tacacctgga 3124981 acatctgtgt atcatccacc agtgagcctt taggagcttc taccgctgaa tttgacacca 3125041 tcagtctgac aataaatgtt ctggcggcaa gcgcctgggc tttcagcgct tcaggtttaa 3125101 aggttgccgg catttcggag gcgacgactc caatcacata ctcttcaagc ggaatgtttt 3125161 ctacggattg atttgcggtt cgatagacgg gaatagaaac aggtgatgct ttcaatgttt 3125221 ctgctccttt cgatgctggt ttcgtgctga ctgctgtctt ttctgattct acgctggccc 3125281 ccgcttcctt attatgctgg aatggtataa ccaagagtgt gggaaccaag agaatcaatg 3125341 cacatagtac ggatagtgtg attgcgaatt gtttcatatt cagctgcctc ctgctcggga 3125401 ttcgactcta gtctagtcta tgggcaggga caagctaata tgactctcgt tttggacaga 3125461 aactttattt gtcatttacg tattcttttt tgctattttg cgcataatga tgataataca 3125521 caaaaaataa aaaaccagta tgccagagtg acatactgat tttcaagtaa gtttatgcat 3125581 ttaagtcaga aacgacttct ttattctctt gctcagaagc agactcatca tttacacgtt 3125641 cgatgtctgc gcccagagcg gcaagcttct gatggaaatc aacgtaaccg cggtctaagt 3125701 gcttcaattc agtaacacgt gtgtgacctt cagccactaa ccccgcaaga atcagcgctg 3125761 cacctgcacg caaatcagtc gctgcaactt cagctccctg aagctgtaca ggaccgttaa 3125821 tgatgacaga acgtccttca atcttgatat caccattcat acggcggaat tcttccgcat 3125881 gcataaaacg gttttcaaaa acggtttctg taatcatgct tgtgccgctt gcacgaagca 3125941 gaagcgccat catttgtgac tgcatatcag tcgggaagcc cgggtgaggc attgttttga 3126001 tgtcaatcgg tttaagctct ttcgggccga tgacacgcag accttcacct tcatccttaa 3126061 ttgttacacc catctcttcc atttttgcaa ttaaagaggt gaggtgctca ggaaccgctc 3126121 cttttactaa tacgtttcct tcagtgattg cagcagcaac cataaatgtg cccgcttcaa 3126181 tacggtcagg aataatatgg tgttttacgc cgtgaagctt ttcgactcct tcaattttga 3126241 tggtgccggt gccagctccg cggatttttc cgcccatgcc gttgatatag tttgctaaat 3126301 caacgatttc gggttctttt gccacgtttt ccagcgttgt tgttccttca gctagagcgg 3126361 ctgccataat caggttctct gtagctccta cacttgggaa gtccagataa atttttgcgc 3126421 cttgcagtcg gccttttact tcagcttcaa tgaagccatt accgactttg atttctgcgc 3126481 ccattgcttc aaaacctttt aaatgctgat caatcggtct ggaaccaatt gcgcatccgc 3126541 ccggaagtgc aactcttgca tgacctgtac gcgcaagaag cggccccatg acaagcacag 3126601 acgcacgcat tttacgaaca tattcaaaag gtgcttcagt ttgcaaagcg tatgaagcat 3126661 ttacagtcac ttcattattt tcaaaatgca catctgctcc taaatgacgc aacacttcgt 3126721 taattgtata tacatcggag agcgtaggta catcacaaat tacgcttttt tcttcacttg 3126781 ctaataaaga tgcagcgata acaggtaaaa cggcattttt agcgccttca actttgactg 3126841 tgccgtttaa cttctgaccg ccgcggacga tgattttttc caaggtattc ccctccgcgt 3126901 ccctaaattc tctatattaa tattcagtcg taacgattgg tgtgccaacc gtaacggtat 3126961 gttttccgcc cattcctgca cttctaagtg caatttgcaa attcatttta tgtttcgagg 3127021 tcataatgta ctcttcccac tcatctgtaa acgcagaaat agaaacgaaa tttggctcaa 3127081 ctacatgttc tactgatctt gcttgaaatt catttaataa ctgatttgct tttttttgca 3127141 aaacaatatt catattatca tctaagtgac catttagaca agtaaaaata actacttttt 3127201 cttggaatat cccaagtgtc tcccgttcaa actgttcata tgtatcattc cagctatccg 3127261 gtgtctctag actcatttgc tcatataata aatacgaagt tggattgtgt tttttgaggg 3127321 ttgtgacaag ctgcagtcta aaagaagtac gatttttttt gtcagtatat gtgccaattg 3127381 cctttatcat tttatcttcc cgtgcaatca cccaatcata ttgacgatac tcttgtttta 3127441 aacgttgcac tttttgataa aattcttttt cggtcagtga caagttttgt tttgcatgca 3127501 atgtccactt atctattgac acatcttgac gttccatccc ctctgccatc tgtgctaacg 3127561 gcgttaattc actcgcatga atggtatgga aaacagcaat gacgaagctt aacatgacgg 3127621 aaatgataat agcgtggctt acttgttttt tcttcatgtt catctctccc ccttatcccc 3127681 agttttaccg gaggcaagag gcgccatacg taaaaatctt cgtcaaaact cgagctattc 3127741 gcttcaaccc gcttctccca accatttaat aatgttcaaa acctattaaa atagataggg 3127801 aagctgctgt gaataattga ggtaatctaa aaagaaattg gcaacggccg ttccaatggc 3127861 gattgtcagc aaaatcatca ggagtcttgc ctgcacgact ttgccttttt tgattaacgg 3127921 atctatattg acggcttgca acgcccacca agtcactgct ataaaaatca ggtgaacgac 3127981 aatgccgatt gcagcctgct gtcccaatac actcatctat tacactcctt tctctgcgtt 3128041 catacccttt cttattatat aagaagcaca gataaagatg atacatttta tacagaacgg 3128101 aataatcagc caaatctagg gctaatcccc gcttaaagtg cgattctttt acatggtata 3128161 ctttattgga aaggagctgg caaatgtgaa tcattctttt tttcagcctg aaaagcaata 3128221 tggtgaggac ctgccaattt ttgatcagga atgggaagca attgcattct attatgatta 3128281 tagacagtca cagattgaag aactgaatga attgtgtcag ttttttaaca tttctcttac 3128341 ctatacgaga gaaagccttg aagagcttga aaacctctat tttcaaagta tacaagaact 3128401 tttgcttgct gattggaatc ttcctattga agaattcgag aaaatgatca gtgtttatct 3128461 tatagattgt gtgattgccc gccatgaaga tgctgaatgg gttgtaaaac cttatcccta 3128521 taaagacggc gcttatacac ttggctttag aagacatcgc aaatcgtggc atacaatgaa 3128581 tgcctgtgat ggtttatacc tgcgtccaaa agaggatcgc ccgttgctgt cgctgtttga 3128641 ttctcttgtg cgttcataaa aaaatccttc tcataaagag aaggattttt tcttatttcc 3128701 ctgctacatc caatctgttc aaagcccgct gtaacgcaag ctcagcccga cgaatgtcag 3128761 tatcatctga ttgagaattc aaacgctcct gcgcccgctg gcgtgcagct tcagcgcgct 3128821 ctttatcgat gccttccgct gtctcggcag cctgggcaag gatggtgaca tgatcaggac 3128881 ggacttctac aaaaccgccg ctgacggcaa ccatttcagt ctgcccgtct tttttcagac 3128941 ggacagcgcc gattttaaga ggagccacgg ttggaatatg gcctggcaaa ataccgagat 3129001 cgccgctttc ggctctcaca ctcaccattt cgatatccgc atcgtatact gggccgtcgg 3129061 gagtaacgat attgacttta acggtcttca tgcttttacc ctcctaggac cagattaaac 3129121 ttctacaccc atttcttttg ctttctcaac aacttcttcg atacggccta caagacggaa 3129181 tgcatcttct ggaagatggt catatttacc ggctaagatt tctttgaagc cttgtaccgt 3129241 ctcttttaca ggcacgtaag aacctttttg tccagtgaac tgttcagcca cgtggaagtt 3129301 ctgagaaagg aagaactgga tacgacgtgc gcggtgaacg acaagtttgt cttcctcgcc 3129361 taattcatcc ataccgagaa tcgcaatgat atcctgaagc tctttgtaac gctgaagcgt 3129421 tgactgtact tcacgcgcaa ccgcatagtg ctcttctcca acaatttcag gagcaagggc 3129481 gcgtgatgta gatgccaacg gatcaaccgc agggtaaata cccatttcag ttaatttacg 3129541 ctcaaggttt gttgtcgcat ccaagtgagc gaacgttgtc gccggcgccg ggtcagtgta 3129601 gtcatcggca ggcacgtaga tcgcctggat agatgtaact gatccaacgt tcgtagacgt 3129661 gatacgctct tggagctgac ccatctcagt tgcaagcgtc ggctgataac caaccgctga 3129721 aggcatacgg ccaagaaggg ctgaaacctc tgaacccgct tgtgtgaaac ggaaaatgtt 3129781 atcgatgaag aacagtacgt cctgtccttg tacatcacgg aagtgctcag ccattgtaag 3129841 gcctgtcaaa gcaacacgca tacgtgcgcc cggcggctcg ttcatttgtc cgaataccat 3129901 ggctgttttg ttgattacgc cagagtcact catttcgtag aaaaggtcgt tcccttcacg 3129961 agtacgctct cctacgccgg cgaatacaga gataccgccg tgctcttgcg cgatgttgtt 3130021 gattaattcc tggattaata cggttttacc tacaccggca ccaccgaaca atccgatttt 3130081 accgccctta atgtaaggag caagcaaatc aacaacttta atacctgttt caagaatttc 3130141 aacttctgtt gaaagctgat cgaatgaagg cgcctgtctg tgaatcggat cctttttcgc 3130201 atccgcagga accggctcat tcaaatcaat attttctccg agaacgttaa atacacgtcc 3130261 aagtgttaca tcaccaaccg gtactgagat tggcgctcct gtatctacag cttccatacc 3130321 gcgctgaaca ccatctgtag atgccattgc gattgtacgg actgtatcat cacctaaatg 3130381 aagagcgacc tcaagcgtta aatcaatacc tacttcgttt tcacttgcag ctggctgtga 3130441 aattttaatc gcattataaa tttcaggcaa gtgaccgtct tcaaaacgca cgtcgacgac 3130501 cggtcctaat acctggctaa cgcgtccttt cttcatcgct atccctcctg acaaaatctt 3130561 tctattctaa agcggctgct ccgccgacaa tttccgtaat ttcttgtgtg atggctgctt 3130621 ggcgagcgcg gttgtaagaa agcgaaagtg aatcgataag ttccttcgcg ttgtctgtcg 3130681 cgtttttcat cgccgtcatt cttgcagcgt gctcacttgc tttactgtca agaagcgcac 3130741 cgaagattaa gctttctgca tattgaggaa gcaaaacctc cagaacctcc tcttcagatg 3130801 gttcaaattc ataagacgcc gttctttttc cgccgccgct gcccaaatca gataacggca 3130861 gaagtttttt ctccgttact tcttgagtaa tggcgctgac aaaatggtta taaacaaggt 3130921 gcaattcatc aaacgcaccg tctataaaca tttgaatcgt ttgacgggca agatctttaa 3130981 tttctgtaaa cgttacttca tctccaagtc ctgttaactc ggaaatgatc ggaatctccc 3131041 gtttcttaaa gaaatcacgg cccactcttc cgatggcaat caccgcatac tcatccttag 3131101 actgatgacg ttcttgcatg gcctgataag cactccgtaa aaccgaactg ttaaaagcgc 3131161 cggcaagacc gcggtcagac gtaatgacaa ggtatgccgt ttttttcact tctctgctga 3131221 gaagcatcgg gtgcttcacg ttgccggaaa ctcttccgac gtttgacaca acctcttgga 3131281 ttttatccat atatggcaca aatgattttg cattgttttc agcacgattc agcttagccg 3131341 cagataccat ctgcatggct tttgtaatct gacttgtttt tttcgttgac gtgatccttg 3131401 acttaatatc gcgtaatgag gccaaagatt tcaccacctt ttctcttcat ctgcgtaaaa 3131461 agagagaaaa agagaacctt tttctctcat cagcattcga gttagttgct tggtgcaaat 3131521 gtgcgtttga agccttcgat tgcagctttg aagtcttcat cagcaggaag gtttcctgtt 3131581 ttcgcaattc cgtcaagcag gtctttatgg ttttggtcaa ggtacatgta gtactcttct 3131641 tcaaaacgtc tgatatccgc cacaggaata tcatcgagat atccttttgt cagcgcataa 3131701 agaatagcta cttgcttttc aaccggaagc ggcttgttca gatcctgctt cagcacttca 3131761 actgtacgcg caccgcggtt cagttttgcc tgagtcgctt ggtcgaggtc agaaccgaat 3131821 tgagcgaatg cttccagctc acggtatgac gcaaggtcaa gacgcaaagt acctgatact 3131881 tttttcatcg ctttgatttg cgctgagccg ccgacacggg atacagacaa tccggcattg 3131941 atcgctggac gtacgcctga gaagaacaaa tcagattgca ggaagatctg tccgtcggtg 3132001 atggaaatga cgttcgtcgg aatataagca gagatatctc cggcttgtgt ttctacgaac 3132061 ggcagagctg taattgatcc tgcgcctttc gcgtcgctaa gctttgctgc acgctcaagc 3132121 agacgggaat gaagatagaa tacatcccca gggaacgctt cacggcctgg cggacggcga 3132181 agaagcaagg acagctcacg gtaagcggcc gcttgtttag aaagatcatc gtatacaaca 3132241 agaacgtgct tgccgttgta cataaattct tctgccattg taaccccagc atacggtgcc 3132301 aggtacagaa gcggtgccgg ctgtgacgca gacgccgtta caacaattgt ataatcaagc 3132361 gcgccgtgtt tacgcaatgt ttctactacg ccgcggactg ttgattcttt ttggccgatc 3132421 gcaacatata cacagatcat gtcttggtct ttttggttca ggatcgcatc gatcgcaaca 3132481 gatgttttac ctgtttgacg gtcaccgatg atcagctcac gctggccgcg gccgattgga 3132541 atcagtgcat cgatcgcttt gataccggtt tgaagcggtt catgaacgga tttacggtcc 3132601 ataacgcctg gtgcagggct ttcgatcgga cgagttttgc ttgtcagaat cgggcctagt 3132661 ccgtcaaccg gctggcctag cgggtttaca atacggccga ttaactcttc accaacagga 3132721 acctccatga tgcggcctgt tctttttact tcgtctccct cacggatctc actgaaaggt 3132781 cctaagatga cgatacctac gtttgattcc tcaaggtttt gagccatacc caaaacaccg 3132841 tttgaaaatt cgacaagttc accggccata cagttgtcaa ggccgtgcac acgtgcaata 3132901 ccgtcaccga cttggatgac tgtacctacg tcttgaactt caatatcaga ttgataattt 3132961 tgtatttgct gttttatcag cgtgctaatc tcttcagctt tgatgctcac ttaggtttca 3133021 ccccttctat cgattttccc cggctaattg acgttcaatg cgctgaagct tcccgcttac 3133081 gctgccgtca taaatccggt ttccaatgcg gactttaata ccgcctatta aatccgtctg 3133141 cacttcattt ctgattctca gtgaagcgac tccggctttt tttgcaaaca cttgtgataa 3133201 tggtaacatt tctgcatccg tcagcggttt cactgaatat acgattgcgt cttctgtttg 3133261 acgggccaca tttgcgagtt tgataaactc atctgtgagc tcagggacaa tcgcggcacg 3133321 atggcggtca atcaaaagaa aaatcgtatt gagtacggac tgtgacaaag agccaaatgc 3133381 attttgaatc agctcttttt tcttcgcagc cggcaccttc ggatggttca acacatcatt 3133441 aagcgctttt tcattttgaa atacttgttt tacaacaatt agctcttctt ctacttgatt 3133501 cagctgagcg gactcattgg ctatatcaaa aagagctgat gcatatcgtt tagagacagc 3133561 tgatccactc atcggctttc tcctacctct ttaagatagt cctggatcaa tttctcttgc 3133621 gcttgttcat ccagttcttt ttcgatcact ttcgacgcaa tcatgacaga aagagacgct 3133681 acttgctcac ggagagcaga aaccgcctgt tccttttcct tcacgatttc agttcttgct 3133741 gcttctttca gacgttcaga ttctgcacgt gcagcctgaa taatctcttc tttttgcttc 3133801 tctcccagtt tctttgcgtt ttcgataaga gtttgggatt cctgtcttgc ttcttttaaa 3133861 agaacgcgct gctcttcaat cagctgctgc gcttctttat ttttttcttc agcagacgta 3133921 atttctccag cgatgtggtc ttcacgctgt ttcattatgt ttaatagcgg ccctaaagcg 3133981 tatttcttca gaagcgctaa taagattaac atagctaaca gttggaacag gatatctccg 3134041 ccgttaaacg acaatcctag ttcaagtggt aattgagaca tctactacgg caactccctt 3134101 ctgcaggttt ttctttgctg atccagcagc cgcacttgtc tcttttcagc cggcaaggcg 3134161 ggatgcttat cagacataaa gcaatggcga aggttctctt ggaatgatct tcgccatttt 3134221 tagttcatat aaggctttta tgcttagcca aagaacgcta agaatgcgat aacgacagcg 3134281 ataataggaa gggcttcaac taatgcgata cccatgaaca taagagttct cagttcttta 3134341 cctgcttccg gctgacgggc aatcccctct accgtacgtg aaacaatcaa accgttacca 3134401 atacctgcac caagtgcgcc taaaccaatt gcaatcgcag ctgctattaa attcatgaaa 3134461 aagttcctcc tttaaaatgt tatccgtttg gatataatgt tttaatgatc atgactgatt 3134521 ttatgagaca tgtacaccat cgtcagcatt gtaaagataa atgcctggat agcaccaata 3134581 aataaactga atgcttgcca tgccagcatc ggcagaatgg caccgattgt accgacaaga 3134641 ccgagagcca cgctttgcga ataatggctt gttgctaatc ccgcaagcag gccgagaaga 3134701 atctcaccgg cgaagatgtt accatacagc cgcaaaccta gagtcagcgt attcgcaaac 3134761 tcttcgatga ttttcatcgg gagcatgaat ggaacaggtc ttaaatagtc tttggaatat 3134821 tccttgagcc ctttcatctt cacaccatag tagtgggtta aagcaacaac catcacggct 3134881 agcgttaatg taatggcagg atcggctgtc ggagacttcc accagagctc atgtccgatt 3134941 gtaatagaga acggcagccc cagcatattc gacacaaata tgtacatcag caatgtgaca 3135001 ccaagtgcca agaagttagc ccctgttttt aaatccattg tactgccaat aatattgcgg 3135061 acgaaatcaa caatccattc cataaagttc tgggcttttc cgggacggat cgaaagcgtt 3135121 cttgtcgtca atatagcaat caataaaaca atcacactcg ccacagtaat catcagaatg 3135181 tttgtcagat taaaagtaag acctagaaat tctatagttc tgtaaccatg attcaaaggg 3135241 ttttcacctc tcttccattg atgaacgttt aagctggata aaggaatcta tcataatgac 3135301 agggtatatt gtcattaatc caataactgt acttgccata tgaaagtatt cgggattttt 3135361 ataggcaaca gccacagcaa gaatcgcatt gcaccaccgc gctgcgctcc cgagagatcg 3135421 tatggacttt cctttctcta cagctctgtc aaaagcattc attcttctga cgagcagtaa 3135481 aaaattaaac aaactgaaaa cagttcccag aataaggcct aaaaaaacgg ttttatacgc 3135541 tgttaaacca taacccagta catacactgc caaaatgaac aataaatatt tgcgttgtct 3135601 gctaaatgta agcttgggat cgtccatcaa ttatctgtct cctgatgaaa aaataatgta 3135661 tagcttggat acggcaaaaa tcagcggtta acccttagta gaagaccttt tttgaccggc 3135721 aaaacgggcc tgttcgaaaa aatcattcat ccgcaagcct tgcagggatg ctgtttcatt 3135781 cgcttaaata aatcctcata atacgggttt gctgagagga tttacattga ggatgaggac 3135841 tataatgaaa gctatgaaaa ccttctcata ataccctcgt ttagcataca atagccccta 3135901 acatgtgtca atctgtttaa agttaaaaaa ctttttatac tttacgtctc cacagaatgt 3135961 tcacattttc acctataatt gtatacagat tcaccgaata gcaaaaaact ggataaaaaa 3136021 atgaaacccc cttttgggga tttcattttt tattttgttc caaacatgcg gtcacccgca 3136081 tctccgagac ctggaacaat atatcctttt tcatttaatt tttcatctag cgccgcaatg 3136141 taaatatcaa cgtccgaatg atgcttctgc aattcttcca caccctccgg cgctgctaca 3136201 agacacatga aacggatatt tttcgcaccg cgttttttaa ggctgtgaat ggcttcaact 3136261 gcggaaccgc ctgtagcgag catcgggtca accacgatga attcacgctc ttccacatca 3136321 gaaggaagct tgacatagta ttccacgggt tttaaggttt ctggatcacg gtaaaggccg 3136381 acatgtccca cttttgccgc aggaatcagc tttaaaatgc cgtcaaccat tcccaatcct 3136441 gctctgagga taggaaccac tccgagtttt ttccctgaga tgactttcga tttcgcagcc 3136501 tgaaccggtg tattgatatc cacttcttcc agaggaagat cgcgggtaat ttcaaatgcc 3136561 atgagtgtag ccacttcatc tactaactct ctaaaatcct tcgtacctgt attttcattc 3136621 cgtatatatg tcagcttgtg ctgaattaaa ggatgatcaa atacataaac ctttcccata 3136681 ctgtgtttca gctccttttt tattgtccca tcaacaatta cacacttcta ttgattctac 3136741 aaaaaaagac attgagtttc aagaacatcg tcaaaaaacc cgccgggcat aagcccaagc 3136801 gggttttagg atcttaataa tctaattctt tatataaagg aaatttatca gtcagagcag 3136861 ctacacgctg tcttgcttct tcaagttttc cttcatcttc gtggtttttc aatgcaagcg 3136921 caatgatagc accgacttct tctaatgcgt ctccgtcaaa accgcggctg gttacagcag 3136981 ctgtaccaag acggatgccg cttgttacga aaggtttttc aggatcatat ggaatcgcgt 3137041 ttttgttaga cgtaatacca atttcatcaa gtacatgctc cgcaacctta ccagtcagtc 3137101 cgagcgaacg aaggtcaaca aggataaggt ggttgtctgt tccgcctgaa acgagctgga 3137161 tgccctcttt cgttaaggct tcagccagac gtttcgcgtt tgaaatgacg ttttgtgcat 3137221 atgttttgaa atcgtcctgc aatacttcac cgaatgaaac agcttttgcg gcaataacgt 3137281 gcatcagagg gccgccttga attccaggga agatcgattt atcaattttc ttgccaaact 3137341 cttcacggca aaggatcata ccgccgcgag gaccgcgaag tgttttatgt gttgttgttg 3137401 taacgaaatc agcgtaagga accgggtttg gatgaaggcc tgccgcaaca agtcctgcga 3137461 tatgtgccat atccaccatg aagtaagcgc cgacttcatc agcaatttca cggaatttct 3137521 taaagtcgat tgtacgagga tacgcacttg ctcctgctac gataagcttc ggtttatgag 3137581 cgagggcttt ttcacgcacg tcatcgtaat caatatattg agtttcttta tctacgccgt 3137641 actcaacaaa gttatattga acaccgctga agttgactgg gcttccgtgt gttaaatggc 3137701 cgccgtggga gaggttcatc ccaagtacag tatcgccttg ctccaaaatc gtgaagtaca 3137761 ctgccatgtt tgcttgtgcg cctgaatgag gctgaacgtt tacatgctcc gctccaaaga 3137821 tttccttcgc gcggtcacgg gcgatatctt caacgacatc gacgtgctcg catccgccgt 3137881 agtagcgttt gcccggatat ccttctgcgt acttatttgt caaaacagat ccttgtgctt 3137941 ccataaccgc ttcacttaca aagttctcag aagcaatcaa ttcgatctta gtctgttggc 3138001 gttcacgctc atttttaatg gcgttaaaca cttgttcgtc ttgcgcaggt aaatgtttca 3138061 tcagcgagat cctctcctat ccgtatcctg ttctttgttt ttaccatcac tattgtacat 3138121 ggtttttaag gccgatgtaa aagattattt ttaaaaaatc taaattttta ttggtaaaaa 3138181 cgaatattaa taacttaaat ttaatttaaa gttcggaatt tatttcacta tcttaaaata 3138241 aaagaaaaga ctggctatgc agtcctttca ttcgcactca taaaccgccc gcactccgcc 3138301 gattagtttc ggccgtgtac gcgccaatgt cacatgagct gaaccgaggc tgttttgaga 3138361 gacacgcaca gggacagcca ccggtttcag atgcatgccg ataaacgtat cgcctatatc 3138421 aattccggcg tcagcctgaa tggtttcaac aagaacagga gacttcatct gcttaaacgc 3138481 ataagacgcc atcgctccgc ccgcttttgg aacgggcacg gcagaaacgg ttggaagcct 3138541 gaacagcttg gctgtttctg cttcgacgac aagcgctctg tttaaatgct cgcagcattg 3138601 aaacgccaga tggattcccg ttttttcccg gagctcagca agtccgctgt agatgctttc 3138661 agcgatatct acactgcccg atgtgccgat ccggctgccg gccacttcgc tcgtgctgca 3138721 tccaaggacg aagagctgat cttgtttcaa ttccgcttgg tcctgaaact cagacagcat 3138781 cgtcttccac gtttgtttca actcattcat taaacagcac ccctacaggt ttttctcttc 3138841 ataatcggag atttttccaa tacgcgtttg gtgtcttccc ccggtaaact cagtagtcag 3138901 ccagattttt gcgatttccc gagccaaacc aggtccgatc acccgttcac ccatcgcaag 3138961 gatgtttgtg tcattatgct ccctcgtcgc cttcgcgctg aaggtatcgt gcgccagcgc 3139021 gcagcgaatc ccttttactt tattagcgga aatgctcatg ccgatgcctg tcccgcaaat 3139081 taaaatgcct ctgtcaactt cgccgctaac cactttttcg gccaccggaa aagcataatc 3139141 cggataatcg acagagccgc tgccgcagtc acagcccata tcaatatatt caatttgcaa 3139201 ttcgtccatt aactctttga tttcatttcg aatgtgaacg ccgccatgat ccgatgcaat 3139261 ggctactttc atctgctttt cctcccagcg tgtgtgatgc ggcccgcccg ctttattgac 3139321 cgcgcagcct gtccgctctt tgattcacac catatgatgt gcttttcact atattctact 3139381 ccttcacgca ggatttgcaa atgacctgtt tgcagatttt ctgacaactt atctacggtc 3139441 ttttttcagc tgttttgcca gctgccgaag aagctcttca agctcatctc gcgtttgttt 3139501 atagatgtca attgagccgc cgaacggatc gaggacatca ccatggctgc ctgtgacata 3139561 ttcttttaac gtaaacactt tatcacgata acgtccaaat tggctggcaa tgatctgttt 3139621 gtgctgatgg gtcatagcca gaaccaaatc agccgattcc ataagttctt cagttaatgg 3139681 agaagacaca tgattaaggg caatgtgttt ttcaaacagc gcttcgactg catgaggcgt 3139741 cgctttccca ttaggtgaag caaacacgcc tgccgagcgg acattgacat tcagcccttc 3139801 cctttctgca attgatttaa aaagcgcctc agccattggg ctgcggcacg tatttccagt 3139861 acagacaaaa ataatatcca tgtcagtcac cccttatttt tctctattat atatgaagaa 3139921 aaaagaaacg gcgacttcgt ttcttttatt ggtatattaa attggcaaaa gcagctttaa 3139981 tccaaacacg attaatatga tgcccccgag cgcttcgctg tatgtgccaa gccatgactg 3140041 cacttgtttt ccgaccagca ggcccagcca tgtcaacatc atgctgaaca gcccgaacag 3140101 ggtaattgtg aggagcggat gcgagccgta tatccccaag ctcaagccga cggaaaagct 3140161 gtcaaggctg acgccgatgg caaacagcaa taagcccggc cctgccggtg acatgaatcg 3140221 ttcttctgac tgtttaaaag aggccataag catttgaacc ccaagaacaa aaagcagcgc 3140281 cccaccgata taaaccgcta acacgccgag gagccctgac agcatgttac cggccgccat 3140341 ccctgcgaga ggcatgatga cgtgaaagag gccgatgatg aaaccaatat agaatatctg 3140401 cttctttcta agtttgacca tgcccattcc aaggccgaca gaaaaagcat ccatccctaa 3140461 agcaaacgcc atgatgctta atgtaatcag ttcgcctata aacaaatccg acatacataa 3140521 ataaccccct tggacacgcc ccgctttttt agcctatgcg tgtccaaaaa gggttagaac 3140581 atctgactgc tttcagcgaa tcactcttcc tccggcggct ttcatcagcc tgttcataat 3140641 agcaagaccg acacctgtat ccggaaagga ttccgctata atgaaatcca ccttattctc 3140701 atcaaagctg cgcaaagcat catacagccc tgccgcaaca gtctcaagct gagcccgtct 3140761 tccgcagctc ttcacataat cagcggaata aacgcccgct ttttcttctg tcgtcaggac 3140821 accgacccgt cttccaccct gttgatattc ttgaatgagg tgctgaatgc gctctgggct 3140881 gccttcgcaa atggcaagag gcgctgtcgg cgcataatgt gtatatttca tccctggaga 3140941 aatcggcttc tcgttttggt cgctgagccc tttatccaca tggatcggcc cgatcaccgc 3141001 ttcaatttgt tccttcgtaa tgccgccagg acgcaagaga acagggatgt cgtccgcaca 3141061 tgaaagcaca gttgattcga ccccgattcc ggtagggcct ccatccacaa taccggctat 3141121 gcggccatcc aagtcgtgag ccacatgctc cgcttttgtg ggacttggct tgcctgatag 3141181 attggcgctc ggtgctgcaa tcggcagtcc cgattcgcga atcaatgcaa gggcaagcgg 3141241 atgatccggc attctaatgg caaccgtttc aagacctgcc gttacacgag gtgaaagcgc 3141301 atcaggtttg caaggcagaa tgagcgtaag tgctcccggc caaaaccgtt tcatcaatgt 3141361 tttcgccttt tccggcgccg ggcccgttaa atcctcaagc tggctgatat ccgcaatgtg 3141421 gacaatcagg ggattatcgc tcggccgccc tttcgcctca tatatttttt tgacggcatc 3141481 cgtatttttt gcgtttgcgc ctaggccata tactgtttct gtcggaaagg caacgacctc 3141541 attttctcgg agcaaagcgg ctgcttgtgc aatttgtgga tcatttgtgg ataactcgtc 3141601 agttacatcc acaaaccatc ttttcgtttt catttctgac caaactcctt attcacaaca 3141661 ataaaacgat tgttttacgc gtgtaatcct tttgaaagta taaaagatgt cctgtaataa 3141721 aacaagcgtt atccacaaat tgtggacaac gctaataaag aagtggataa gtatgtgtat 3141781 aaactgcact tatccagacg cttttttcat caaaacggct ccttctgttt gccgcgattc 3141841 acagaagtga tcagaagaaa acagctcctc cggtacactc tcagctcttt caaaacccat 3141901 ggccgtcaga aagtccgcag aggaatgctg atttgctact aggtacacgg ttttgatctg 3141961 atgcttttcg cacagcacct ccatgctttg aaaaagcgtg acgatgtggc cttggtgaag 3142021 cttgtccgat atgacaagtg atcgcagcag cccctggtca cagcttattt tttcaatacc 3142081 gaggcatccg gcaatgtttt tctcactgtc ctccagcata agaaattgag tgaagccttc 3142141 tttcacgcct tcatagctgg tttttgcctg ttttaaaaat gcctcgagca catctccgtc 3142201 tttttccctt gccacccgca gttgataaaa catccgttca ccccgttttt gcgttctttc 3142261 ttccaatcta tgaggcaaat ctatttttag accagatgat taggaaaaaa ggtcggaaat 3142321 ccattcgact aaaaagaatt tcacttctgt gccgtcttct ttttcttcgt tctcttcttt 3142381 tttggctttt tccgctttag cggttacgtc ctcaagcact ttttcagtct gcttttttga 3142441 ggcttcttta tcttcttgtt ctttgacggc ttccccgtta gaaaaatcaa gaaagcagag 3142501 gggcgggaac agcacacacc accagttggc gccgtctccg tttccaagcg taatcaaaat 3142561 cgcttcatac tcaccagcgg gatataccat gttgccgtaa agctttgtcg gaaacgagat 3142621 tttgtcaaaa tcaacggata tcgactgatt cgctccttct ttctccattg tttcctttgc 3142681 aattgctttg atttcaggca gctttgaacg aatcacgcga cgcgcttctt caatagaagt 3142741 aatatccttt acccaagttg tgatttcttt attcaccgcg tctcttatat gacgttttaa 3142801 ttgctggtct tgatcactat cgctgtttgc cagtattctc aaacgaatcg cctgatcagg 3142861 tatgaccacc ggctgatttt ccgatttttg tgccgtctct tcttttgcca gccctacgag 3142921 cgctccggat aataaaagaa agatatatat acaaatgatt actgtttttt tcatcggtcc 3142981 ccaccgttcc tctccgtgct ttgtttctag ccctattatg gacaaggaga gcctgggata 3143041 aacgtgcagg gtgaaaaaaa tctagcaagc tgttaatctt atttatggta cgatagtgtt 3143101 ttaggaggtt taagatgaaa tacaattata cagtgctgtt atcagcattc acgatgtccg 3143161 ttctttattc agtaatttat attcattcat ttatcattgc cgctctcatc acaatggcat 3143221 tttattttct gtttccttat ttgatcttcg cactgccgct tcaaatcatg atgaataaaa 3143281 agccgaaacg tttcagccct ttgtatctgc tgtattacct tgccgctgct tttattgcca 3143341 acgcgatcat tttcggcatg cttcagcctt cgggacaatc tctgtttcaa aatacagcct 3143401 tttatctttt cgctgtatta acagctctta tctattggat atgggattct gttttactgc 3143461 aaaaaaagga agcctaagag gcttcctttt ttattaaaac aaaatcgtca gtaaataaca 3143521 tagaatggaa ggtatcgccg caacaaagaa agcggccgcc attttcatgc gagatgtacg 3143581 gccttctttg gtttctgaat ggtagtttgc ccgctgatcg cttccgctta cagccaaacc 3143641 cgatgtaatg atcgcgagcc ccactaaaac gagagacgca acgccaaaaa tcgcttcata 3143701 tgaaagagcc tgcggaaaaa tggtgccaat catgctctca atcgcaatga gcaggattcc 3143761 tgctgtcagg gcctttttca tgtttacatc ccctttgctg gtgttaaaca gcttgatcca 3143821 ttcactcgcc agcaagctgc ttatttattt ttatgaatca gagcgcatat ggttctgtct 3143881 tttccattaa tatctttcag cacttccact tccgccccct taaacgcctt gaggatcagg 3143941 tctttgaccg ccgctccctg tttccagccg atttcaaaaa cgacaaatac tttatccttc 3144001 ataacaagcg gaatgtcttc cataaaccgc ttataaaatt tcagcccgtc tccgccatcg 3144061 gtgagtgcgt gcagcggctc atgaaaacgg acaatttccg ataaatcagc catttcttcc 3144121 tctgaaatat atggcgggtt tgagacaatg atatccgctt tttttcccgc cttaataaaa 3144181 ggctcaagca gatcgccctg ataaaagcgc acattcgctc cgagtttttc tgcattggca 3144241 gaggcgactt gcagcgcctc tttcgaaata tcgaccgccg acacagaaaa gctttggttt 3144301 tcaagcgcaa gcgtgacggc tattgcgccg ctccctgtac caacgtcaac aacttcgagc 3144361 ttgccgtctt cagaaaaaac actccgatat ttttcaagca aatgaaagac aacttcttca 3144421 gtttccggcc gcgggatcag cacatcatca ttcaccataa attcccgtcc ataaaaaaac 3144481 tcttttccta taatgtattg aaccggcacg ccctctttat gcatctcaac gtgacgctta 3144541 aagcgataca gttcgtcttc accaatcggt tcctgtaagc ttgcgagcag cttgcttctc 3144601 tccattccgg tatcataaag caataggagc tcggccgcat tttcttctct tcccgcttcg 3144661 gttaaataag aagaagccca tttcagggct tcgaatatcg tcttcatctt aaccttccga 3144721 ctgctgaagc ttgcttgcct gatcttcaac aatcagcgct tcaaccactt cgtcaagttt 3144781 tccttcaaga atctgatcaa gcttttgaat cgtcaaaccg attctgtgat ccgtcacacg 3144841 gttttgcggg aagttgtatg tgcggatacg ttcagagcgg tcaccagatc cgactgctga 3144901 tttccgtgtt tgatcatatt cagcctgggc ttcctgctga aatttatcat agattctggc 3144961 acggagaacc ttcattgctt tttctttgtt cttaatttga gatttttcat cctggcatga 3145021 tacaacaaca cctgtcggca agtgagtcag acgaaccgca gacattgttg tgttaacgct 3145081 ttgtccgccc ggtccgcttg aagcaaatgt atcgacacgg atatccttct catggatgtc 3145141 gacctctacc tcttctgcct caggaagaca tgccactgtt gcagtggatg tatggatgcg 3145201 tccgcctgat tctgtttccg gaacacgctg tacgcggtgg gcgccgtttt catatttgag 3145261 tttagaatac gcgccgcttc ctgtaatcat aaagatgatc tctttgtagc cgcccgttcc 3145321 ggttacattc gcttccatga cctctgtttt ccagccctga agctcagcat aacgggaata 3145381 cattctgtac agattgcccg cgaataaagc ggcttcctcg cctcccgcag ccccgcggat 3145441 ctccatgata acgtttttgt cgtcattagg atctttcggg atcaggagca ccttcagccg 3145501 ttctgacagt gtttccgttt ccttctgaag ttcagaaatc tcttccttca ccatgtcgcg 3145561 catctcagca tccagcttct cttcaagcat cgcttttgca tcagccagct gttctgacgc 3145621 atctctgtat tgtctatata cgtcaactgt ttcttgtata tcagattgct cttttgaata 3145681 ttctcttagc tttttcggat cgttgactac ttctggatcg ctcaaaagct catttaattt 3145741 ctcgtatcgt tcttcaattg attttaaacg gtctaacacg gtcttcacct ctgttttcct 3145801 gtgcgtaaca ttctcattat agtatagtga ttaaccccag tcaaaagcat ttcaatccca 3145861 gctggaaaag ctccctctgc tatactggaa ttcgaggagg gatgatgttg ctgaaatcca 3145921 tacatcatat tgcaatcata tgttcagatt acgaaaagtc gaaagctttc tacgtacata 3145981 agcttggttt tcaggtgatt caagaaacgt accgcgaaga gcgcggctcc tataagcttg 3146041 atttgtcgct taacggctcg tatgtcattg agctgttctc gtttcccgat ccgcccgaac 3146101 gacaaacccg gcctgaagcc gcaggcctgc gccacctcgc ctttacagtc ggcagcttgg 3146161 ataaagctgt tcaagagctt catgaaaaag gaatcgaaac agagccaatc agaacagatc 3146221 cgctgaccgg caagcgtttc accttctttt ttgatcctga ccagcttcca ttagaactgt 3146281 atgaacaata acagtttttg aagaaaaaaa ggagataccc actttctttg ccgaatcttt 3146341 tcttgttttg tctaacggga agggaaccgc attctatggt cgaataccta gcttaaaagg 3146401 aggtatggga tcatgaatac aaatatggta gcaagtgaac tcggcgtctc cgcaaagacg 3146461 gtgcagcggt gggtgaagca gctgaatctt ccggccgaac gcaatgagct cggacactat 3146521 tcgttcacgg cagaagacgt gaaggttcta aaatccgttc aaaaacaaat ctctgaaggc 3146581 acggcgattc aggatattca tctgccgaaa agcgctaaaa agcgcacagg cttccttgtc 3146641 caaaaaacaa gtagcgacac agaacgaaga atcgagcagc ttgaacaaaa gctggacacc 3146701 cttttacagc aaaggcagga cgaaagcgaa ttgatggcaa ggatgtcgga actggaacgc 3146761 cagctgaaac aaaaagccga tgaaggtgta tcttaccagc tgcttcagca ccgcagagaa 3146821 atcgatgata ttcttgcaga tctgcaatca ctgacctcac aaatgaaaga attcaccgct 3146881 cattcgatcc ccgagactgc tgctgcttct gaaaaaacca aaacaagaaa aaaaccgctg 3146941 ctgtcactgt tcaaatttca aacctaaagc aaaaagctcc cttaaaggga gctttttttg 3147001 ttacgcagta agcgcgataa tgattggaag tgaaatcaat gacagaatcg cactgaccac 3147061 aaacgcagtt gcagtttctt cttcttgttt ctcgaaacga gtcgcaatca tggctgcaac 3147121 ggcagaacca gggaatgcaa caagaaggat tgcttttgtt gtttggtcag ctggaagtcc 3147181 gatagcaaga gcaatcagga acattaacgc aggctgaacc gcaactttta gtaacgcaat 3147241 accgatagcc ggcatactga gtttaatttt acgaatacca acggtaacac caacagcgaa 3147301 gagagcaaca ccagatgttg tgcttccaag ctgatcaagc attttaacac ccagctcagg 3147361 aagagtgaaa ttgaaaacca gcaccaagat catactgatt aacggagcag ctgcaagcgg 3147421 ctcacaaaga ccatgcagga ttgattttcc tgtcatcttc cagaagctgt cgccactctc 3147481 ttcgtttttc ttagaagact caccaacagt agcgataatg atcgcgagcg gatcaagaat 3147541 cgcgttaacc acgatacctg tgaccgcgat cggaatcgca acttcattcg ctccgaataa 3147601 gcttcccaat accgggatac ccataaatgc gaatgtcggc tgtgcagagt tcaaagaaaa 3147661 tacagatgag ttcgttaaat catacttgaa tataaatctg caaaccaaaa gaatgatgat 3147721 atagaaacca acaatcccaa taattaaaga aatcattaaa ggtacttgtg ataaaaattc 3147781 acttctggaa gttgtcaaaa taccagcgat aaagtgagct ggaagtgcgt atttcgttac 3147841 taacgtactt accccttttg ccgacttggc atcataactt ccaaaatgtc ctgcaaacca 3147901 acccagcacg ataacaaaga agatcggcgc caggaggatt aagatatcta agatgctcaa 3147961 aatattctcc tccaaatcct atgtccgtat actttagctt tacaaaaagc tttccctcgg 3148021 acagaaaaat ttactcgcta attatttcgc gatgactttt ttgtattcag gtgtccacat 3148081 tgcatcaagt accgcttgtt tcacatcttc aggctgacga tttgccacgc cgtctttaat 3148141 tgctgcttca gcaacggcaa tcgcaacttg gatagaaacc tcttgaagct tatcaatgct 3148201 tggaagcaat cctgctccag gtgtttcaag atcaaccatt tcagcaatcg catcagcagt 3148261 tgcagcaaac atagcaggtg taatgatacg cgcttcagct acaattgaac caagtccaag 3148321 accagggaac gcgaatgcgt tgttagattg tccgatttca taagaaacac cgttgtattc 3148381 tacattgtca aatgggcttc ctgttgcaat aagcactttt ccgtcagtcc atttgaacag 3148441 atcttcagga acagcttcag caaggtgagt cgggttagac atcggcatga taaccggacg 3148501 gtctacgtga gatgccattt cttttacaat ttcctctgtg aatgcacctg aaacccctga 3148561 agtaccaatc aagattgttg gtttcgcttg acgaacaact tcatcgaatg gaatttgacc 3148621 tttttcatcg cgcttccagt ctttcacttc atccgcattg cgaaggtaag gtttttggaa 3148681 atcaaggatg ccttcgatgt cttcagtcag caagcctctg taatcaagtg tgtagaaacg 3148741 tttgttagct tcttcttcag ataatccggc tagcaccatt gtgtcacgga tttggtcagc 3148801 aataccgata ccagcagaac cagcaccgaa gataacaaca cgctgatctt taatagaagc 3148861 gccggttttc ttcatagcgg caagcacacc tgcaagtgta atcgcgccag taccttgaat 3148921 atcatcatta aatgtcagga tttcatgatt gtattttttc atgatgttgc gtgcattttt 3148981 gttgccaagg tcttcccagt gaagaagcgc tttagggaag aatttcaatg cagcttttac 3149041 ataagcgtca atgaaagctt cgtagcgttc accttgaaca cgttcatgct tgttaccaat 3149101 atataaagga tcgtttagaa gtttttcgtt gttcgtaccg acatcaagca caaccgggat 3149161 aacacggcta gggtcaatac cagctgcagc agtgtagaca gccaatttac cgattgcaat 3149221 attaataccg cctacacccc agtcaccgat accgagaatg ctttcggagt cagtagcaac 3149281 gataagatca atatcgcctg ctgtcgcatg aaggttttca aacgcttttt caataccgtc 3149341 aatgttatcg attgacaagt agattccttg aggtcttcta tattcatggc tgtattcctg 3149401 aatcgcttca ccaactgttg gcgtgtacac aacaggaagc atttcgcgaa gatggttttt 3149461 cagcaattta tagaaaagaa cttcgttacg gtttgcaaga tcacttaagt aaacattttg 3149521 acgaaggcgg tcaggctgcg cttggaattg ctcgtacgcg cgttgtgctt gttgatcaag 3149581 agaaagtaca gttggcggca gaagcccttc taagccgagt tcttgtcttt cttctagtga 3149641 aaaagcaacg cctttattta aagtaggaat agataaaact tcttttcctc taagagttgt 3149701 ttctaagtgg ccttctttcg ttttttttat gttattcaag caaatctcct tctttcttga 3149761 aatagttaac caagttaagt aataacccat ctaaaatatg accgatcatg atctttatgc 3149821 gactttgtga caattattcg aacaatgtct caaaactatt tacattacgt aagctattgt 3149881 atgcctgtca aaatcaaaat tcaagagaag aaaattactt aattttttaa tatacttatt 3149941 taaatttttt aattgaatat tatcagaata taaaaaaaac accggtgttt ttagccggtg 3150001 cattctatct ttatacccat gttttggact attttttaga tttacctggg acttcgtgat 3150061 gatgtctgca tcttgcttca tatgattcag ctgcaccaac caaaatgacc ggatcatcgt 3150121 aagaagcagg tttgccgtca atgaggcgct gtgttctgct cgccggtgat ccgcaaacag 3150181 aacagacggc ttgcagcttt gtcacacttt ccgcaatcgc catgatattc gggacgacac 3150241 cgaacggctc tcccctaaaa tccatatcaa ggcctgctgc tatcacacgg tagcctttat 3150301 cggcaagaga tgataaaacc tcaacaattt cctgatcaaa aaactgcact tcatcaaccg 3150361 caaccacatc tgtactttca ctgatgtgat cccaaatgtc cgcagcagac gaaatggcat 3150421 agctcgtcat cgatgttcca ttatgggaga caacagcagc ttcgctgtat cggttatcaa 3150481 ttacaggctt aaataccctg acttcctgct tggcataagt tgctctcttc actcttctga 3150541 tcagctcttc agatttcccc gagaacatgc tgccgcaaat cagctcaagc cacccgcttt 3150601 gtttcattat gtacataggc ttcgctcccc tctctctgcc agctgtgttt tagacaatat 3150661 aaaaaacagg caagactgct gcttgcctgt tgagaaatct attattactt aagaccgtat 3150721 tttttgttaa agcgatcaac acgaccatca gcagaagcga atttttgacg gccagtgtag 3150781 aatgggtggc attcagagca aatctcaacg cgtacctctt cttttactga gcctgtttca 3150841 aattcatttc cgcaagcgca tttaactgtt gcttttttga aattaggatg aattcctgct 3150901 ttcattgtat ccatctcctt ccgccctgaa tcccgtgtgg aaacagagtt attatttcgg 3150961 agcattgtcc gaaacgcata tgagaaaatt atatcagtga tttacttctt ttgcaaatac 3151021 aatttacctt cttgcagatg atagatttgc ctgtttccat tcttgattga gaatatcgaa 3151081 aaattcctgg tttgttttgg tttttttcat ttttctcatg aacttttctg cgaaatcagg 3151141 tgaatcagac atcgttttgc ggatagacca taaacgatca agatgctctt taggcacaag 3151201 cagctcttct ttgcgcgttc ctgaacggcg gatatcgatg gcagggaaga tgcggcgctc 3151261 ggcaagagag cggtcaagat ggagctccat gttgcctgtt cccttgaatt cttcataaat 3151321 gacatcatcc atacgtgaac ctgtatcgac cagagccgta gcaaggatgg ttaagctgcc 3151381 gccctcttcg atatttctcg cagccccaaa gaagcgtttc ggacggtgga acgccgctgg 3151441 gtcaatcccc ccggaaagcg ttcttccact tggcggaatc actaagttgt aggcgcgggc 3151501 aagacgtgtg atgctgtcca tcaggataat gacgtctttt ttgtgttcca cgagacgcat 3151561 cgcacgttca agcacaagct cggccacttt gatatggttt tccggcactt catcaaacgt 3151621 tgagctgacg acatccccag ctacagagcg ctcgatatcg gttacttcct caggtctttc 3151681 gtcaattaaa agcacgatca gctctgcttc aggctggttc gctgtaatgc tgttggcaat 3151741 ttccttcagc aacatcgttt ttccggcttt cggcggcgca acaatcaatc cgcgctgccc 3151801 aaatccaacc ggcgccatca tgtccataat tcttgtagac aagaagttcg gctttgtttc 3151861 aagcaccatt tgacgatccg gataaagtgg cgtaagagcc gggaaatgca cacgctcttt 3151921 tgcagattcg ggatcatccc catttactgc ttcaacgtgc aaaagtccat agtaacgctc 3151981 attttctttt ggcgggcgaa ccttgccaga tactttgtct ccgttccgca aatcgaaacg 3152041 gcggatttgt gaagctgaga tgtaaatgtc ttctgagctt ggagagtagt tgatcggtct 3152101 caggaatccg aaaccttcag actggatgat ctcgagaacg ccttccataa acagcagatc 3152161 ttcctgttct gcattcgctt tcagaatggc gaaaatgagt tctttttttg tcagtttgct 3152221 gtaataggag attttataat gtcttgcaag ttcataaagc tctttcaatt tcatattttc 3152281 caaagaggaa atagatacgt ctttcataaa aacaccacgc ttttcatagt caatatctta 3152341 ctctgaacat gtcatctgct gcttttgcac aacatccgcc aaagcacatt ctttttttaa 3152401 cataaaggaa cttctatcgg taacacttcc acccatgatc ggcgcttttg ttaaaaggat 3152461 tgtcttaatg agttttgaag gaagcgagga caaaaacatg agaagatcaa tacttatatc 3152521 gtctgtatgc ggtagaaatt gaaactttcc tagtgcttaa aagaaggtat tacgcagtaa 3152581 aattcgcagc actctttatt tttaccttat ttcaaaaaat tattcaactg aaataaggtt 3152641 ttgacacgga attgatagag ttgacgcttt tctgcaaaag ttaaagcggg ctcacacccg 3152701 ctttttctgt ttgttatgga cggattacaa gatttggttt ctttttcaag ctgtgtctgc 3152761 cgtcaacgaa acgaacagtg cccgattttg cacggataac taagctttca gttgtaccga 3152821 cagagccttt gaattgaact ccttttaaca gctcgccgtc agtaacccct gtagctgcaa 3152881 aaatcgcgtc atcacccttc acaaggtctt ccatgcgaag cactttgctt aaatcaaggc 3152941 ccattttgtg acagcgagtg atttcttctt cgctttgcgg aagaagttta ccaatgattt 3153001 ctccgccgag tgcttttagc gcaacagcgg aaagcacacc ctcaggagcg ccgcctgatc 3153061 cgaacaggat atcaacgccc gtgtggtcga aagccgtgtt gatggcgcct gcgacatcgc 3153121 cgtcattgat caatttgatt ctggcgccgg cctcacgaag ctcggaaatg atttttgcgt 3153181 gtctttcacg gtttaaaatt gtggcaacga cgtcctcaac gtccttgttt ttcgcttttg 3153241 ccaccgcttt aaggttgtca atgacaggtg cttcgatgtc aatgcagccc accgcttccg 3153301 gaccgactgc gattttttgc atatacatgt caggagcatt cagaagcgtg ccatggtctg 3153361 cgaccgcgat aaccgtcagc gcgttccagc cgccgcttgc taagatgttt gtgccttcaa 3153421 gagggtcaac tgcgacatca acgcgagggc cgtacccgtt tccgagtttt tccccgatat 3153481 acagcattgg cgcttcgtcc atttcccctt caccgattac aacggtccct ttcatcggca 3153541 ctgtatcaaa aacgtctctc attgcacttg ttgccgcttc atcagcctca tctttttttc 3153601 cccggcccat ccatcttgct gatgccaatg ccgcagcttc tgtcacacgt accaattcca 3153661 ttgataaact tctttccatt tcaacacgat ctcctctcac aagaaaccat tatgaatttt 3153721 gaagctgttc tatttcttcg tcagtcattc tttcacgcca aattgtcgct ccaagcccct 3153781 caagcttctt ctcaaggctg ctgtatcctc ggtcaatatg ctccagtccc gtaatttccg 3153841 tgacgccatc agccatcagt ccggctacca ccaagcaggc tccggcacgc agatcactcg 3153901 ccttcacttt tgcgccttga agctcgacag gacctgtgat gatggcagat ctgccttcta 3153961 ctttcatatt ggcacccatt cgtctcagct catcaatgtg cttgaatctt gccgagtaga 3154021 tggtgtctgt gacgacactc gtccctttcg cccttgtcag gagcgccgtc atcggctgct 3154081 gtaaatcagt cggaaacccc gggtatacga gggttttgac gtcaaccggc tttaagttct 3154141 tctgcccgcc gacaatgagg agctggtcgt cgcttgtttc gatatgatag cccatttctc 3154201 tcagctttgc cgttaacgac tcaagatgag tagggatgac gttatcgata atgacttcct 3154261 tgcccattgc agcccctgca atcataaatg tcccggcttc aattctgtcc ggaatgatcg 3154321 tatgcttgca gccgtgcagt tccttcacgc cgtcgattcg aatcacattg gtgcccgcac 3154381 ctttgatttt ggcgcccatg ctggtaagca atgtcgcgac gtcaatgatc tcaggctcct 3154441 tggcagcgtt ttcgatgatc gttttccctt ctgccaaaac agcggcgagc ataatgttaa 3154501 tcgttgcccc aacgcttacg acatctaaat aaatccgtgc gcctctcagc ctttcagctc 3154561 gcaaataaat ggcgccttgt tcattggtta cttcagctcc gagtgcttca aagcctttga 3154621 tatgctgatc aatcggacgg ggccctaagt gacagccgcc aggcaatcca atgaccgcct 3154681 gcttgaagcg gccgagcatc gcccccatta aataatatga cgcgcgaagc ttttttactt 3154741 tcccgttagg aagcggcatg ctgatcatcg acgtagggtc aacaaccatt tccccattct 3154801 caaaatgcac gttgccgccg atttccttta acaggtcacg cagcgtttca atatctgaaa 3154861 tctctggaag cccttcaatt gtcacctcgg aatttgccaa aatggttgca ggtattaacg 3154921 caacagcgct gtttttagcg ccgctgatat gtactgtacc gtttaacgag tcaccgccgg 3154981 caatattcaa cttttccatg atagtctcct tccataagaa gatagctgcg gagctaaata 3155041 aaatgtcatt ttattctgtc tctgcaaata aagctcatgt ccaaaatcta gccaattcga 3155101 agagaaagaa tacaacacat tgtaaaatat caggaagaaa atagcgaagc tttggggggt 3155161 acaggtttca aaagatgcac agagacccgc cggctcgaga gacatcgtcg tcatccggca 3155221 aaagcagtac gcataccctt cattccgata tcagcttctg cagcccaatg attccttctc 3155281 tgtaaagcgg cgtcagcatc tgaagatccg ctgtatcagg tcggtgaaat acaaaggccg 3155341 cggcaaacag gcataaagct gtttgccgcc cctttcatta tttgttccag tctgccagga 3155401 attgttcgat tcctttgtct gttaacgggt gtttagtgag cgcatgaatg actttcagcg 3155461 gcattgtgcc gatatgagcc cctctaagag cagcttctgt cacgtgctgc ggatggcgga 3155521 ttgacgctgc aatgatttgc gtgtcaaggc cgtgaatgtc aaaaatctgt ttaacttctg 3155581 aaatcaggtc aagcccgttg tggccgatgt catctaaacg tcccaggaat ggagatacat 3155641 atgttgcccc cgctctggca gcaagaagcg cctggttggc attgaagatc aatgtaacgt 3155701 ttgttttgat gcctaagtca gtaagtgctc ttaccgcttt taaaccgtca gacgtcattg 3155761 ggattttcac cgtaatgttc ggagcgatct tcgccagttc ttttccttcc tcgatcattt 3155821 cctcagcttt caaagaaata acctctgcgc ttacagaccc tttcacgacg tctgtgatct 3155881 cgcgaagacg gtcgtggaat gatacgttag cttcctttgc tactaaacta ggattcgtcg 3155941 ttacaccggc gagaattcct aattcattcg cttctctaat ttcatcgata ttggctgtat 3156001 caacaaagaa taacattttc aaaaagcctc cctgattaag aaattttctg aactgcgaat 3156061 atgattgcgc tttctaaaga tagacggaaa accgcctgtc aagctgtcag gcggctataa 3156121 aaagttccaa ttgaattaag cttggtttga agaaccaaat tcacgcattt taccgataac 3156181 tgtttctttg atcgcttcac gagctggtcc aaggtattta cgtggatcgt actcgtcagg 3156241 cttagctgcc aatgtttcgc gaacagcttt tgcagaagaa atttggtttt cagtattcac 3156301 gttgatttta gctgtaccaa gtgaaattga ttttttgatg tcagcagtcg gaattccagt 3156361 accgccgtga agaactagcg gaaggccagt tgattttccg atctcttcca tttctttgaa 3156421 gccaaggttt ggctcacctt tgtaagggcc gtgaacagaa cctaatgcag gtgcaaggca 3156481 gtcgatgcca gtgcgctcaa caagctcttg gcactcttta ggatcagcgt agattacgcc 3156541 ttcagcgata acgtcatctt cttgtccgcc tactgttcca agctcagctt ctacagatac 3156601 tccgtggaaa tgagcaagct caacaacttt agcagttgtt gctacgtttt cttcaaatgg 3156661 atggtgagaa gcgtcgatca ttacagatgt gaaacctgca tgaatcgctt tcgcacaaga 3156721 ttcaaagctt gaaccgtggt ctaagtgaat cgcaacagga actgtcactt tgtactcttc 3156781 cataagtgct tttaccatag caacgactgt tttgaagccg cccatgtagc gtcccgcacc 3156841 ttcggaaaca ccaaggatca ctggagattt ttcttcttca gctgcttgta aaatcgcttg 3156901 agtaaactca aggttgttta agttaaattg tcctacagcg tacccttttt ctttagctgt 3156961 attcaacatt tccgtcatag aaactaaagg catgtcgaat gtcctcctta tgtagcctga 3157021 ttgtcttcta gcgaaaaaag ctttccaccc tagcatgacc catatattgc tgtcatatgt 3157081 aaatactcag atcgcttttt ctccataact aggataccaa cttttcgaca aatcggcaac 3157141 ataatgacat gattcatttg tttcttcttt ttgtcagtta gacttcaggg gcagatattt 3157201 tttgacggcg tctctgattt cgtcgatgtc aaacggcttg gcaaagtgcg tcagagcgcc 3157261 caattccttc gattcctgga tcatgtcgag ctctccgtat gccgtcatga taatgacccg 3157321 gatgttttcg tcaatgacct tcatccgttt taagatttcg attccgtcca tgccgggaat 3157381 tttcatgtcc aacagcacaa ggtcgggccg ttcttttgtc acaatgtcaa gcgcctgcag 3157441 gccgttcgca gcctgaaacg tctggtagcc ttctttattg aacacttcat ttagcaaaat 3157501 acgaatgccg tattgatcat caacgattaa aattttttca ttcatcattt tacaccccaa 3157561 tattatgatt ttcgtcaaaa gtaagcagta ttgtatgtat tctgtttgat tttcctattt 3157621 cctttaatta taatagtcta ctttacgaca ttttctgagc attttctctt ttgttgtata 3157681 ctgatattgt acgttataaa ggaggattca cttatgttga aaatattcac gacgcagtta 3157741 acaggtattt tttcccgcat tcaggataag gaatctgacg cgattgaaga tggggcgcgg 3157801 ctgcttgctc aagcggtgat cagcgggcat tccatttatt tatacggagc gaatgagctt 3157861 cagggcgtct tttatgaggc caccgaaagc aaagaaccct tcccatctgt caaagccttt 3157921 ccagaaaacg ctgaggaagt gacagaaagc gacagggtgc tgatgttttg ctcagggacg 3157981 ggcacagccg aagaacagga gctcgcaaaa gagctttatg aaaaaggtgc gggagtcgta 3158041 tgcgtatcgc ccgcagccaa agacagtgcg ggaatagaac agtattgtga tgtgcatatt 3158101 gattctaaat taaaaatgcc gcttgttccc gatgaagacg gcacccgtta cgggtttccc 3158161 tctttaatga cagcactgta tgtctatcac gctttatcgt ttacactaaa agaaattctg 3158221 caagagtatg cataatatct tattgtacat gctggaactt gccggaaaca aataaaaaag 3158281 acttgcccgc ttttgacaaa cggcaagtct tttttattac ttctgatttg cagcttcgac 3158341 agacgctccg ataaagcctt tgaatagagg ctgaggtctt gtcggtcttg acttgaactc 3158401 tgggtggaac tgagaagcca cgaaccaagg gtggtctttc agctcgatga tttcaacaag 3158461 gcgtccatca gggcttgtgc ctgagaatac gaagccttgc tcttccattt gctgtctgaa 3158521 ttcattgtta aactcatagc ggtggcggtg gcgctcgtac accacttcat cctgatacac 3158581 ttcaaaggct ttcgtgcctt cttcaagctt acaagggtaa aggccgagac gaagcgttcc 3158641 cccaagatcc tcaacatcct tttgttcagg aagaagatca atgatcgggt attgagttga 3158701 cggatcaatt tccgctgagt gagcgccttt taagcccaat acgtttcgtg cgtattcaat 3158761 agacgccacc tgcatgccca agcaaatgcc caagaacgga atgttgtttt cgcgcgcgta 3158821 ttttgtcgcg acgattttcc cttcaacacc gcggtctccg aatccgcccg gcacaatgat 3158881 gccgtctgtt ccgcttgtga gttctgcgat attgttttct gtcacttctt ccgcgttgat 3158941 ccacttcact tttacatctg tgtcaaacgc atagcccgca tggcggagag actcgacaac 3159001 agaaatgtat gcgtcaggaa gctcaacgta tttgccgaca aggccgattg taatcgtttg 3159061 agacaggttg ctgactttgt taacaagctc tttccactcg gacatttccg cttctttgca 3159121 tgccaatttc atgtgctcgc aaacaagctt atcaagccct tgtttttgaa gctccagcgg 3159181 aatggagtaa aggttgtccg catcttcaca ttcaataacc gcttttgtat cgatgtcgca 3159241 gaaaagcgcg attttatctt tcatatcttg agaaatcggc atttctgtac gaacgacgat 3159301 gatgtttggc tgaatgccca agctgcgcaa ttcttttacg ctgtgctgtg tcggttttgt 3159361 ttttaattcg ccagcagctt taatgtaagg cacgagcgta cagtggatgt acattacgtt 3159421 ttcacggccg atgtcgctct tcatttggcg gatcgcttca aggaatggca gtgattcgat 3159481 gtctccgaca gtaccgccga tttctgtaat gacaacatct gcgtttgtct ctttccctgc 3159541 gcggtaaaca cggtctttca attcgtttgt gatgtgcgga atgacctgta cggttcctcc 3159601 aaggtaatct ccgcggcgtt cttttttaag aactgttgaa tagattttac ctgttgtcac 3159661 gttgctgaat ttattcaggt taatgtcgat aaaacgctca tagtgaccaa ggtccaagtc 3159721 tgtttcagcg ccgtcatccg ttacgaatac ttcaccgtgc tggtacgggc tcattgttcc 3159781 cgggtcaacg ttgatgtatg gatcgaattt ttgaatcgtc acgttcagtc cgcggttttt 3159841 cagcaaacgc cctaatgaag ctgctacaat accctttcca agtgaggata caactccccc 3159901 ggttacaaaa atatatttcg tcatttcgtt tgctcctctc ttcgctctta gctacatttt 3159961 taaaatgtac tattttataa aaaatcattt agccttttaa atgatttata agaaaaatga 3160021 ggggtgaaaa taagaaagct ccctttcaat ttcttgaaag ggagcataac gtactatgtt 3160081 ctctcttcgt ttttgaagag cccaaaatac atactacata gttcgactat gaaagtcaag 3160141 atcgttttga agatgaaatc tgatactatt taatttcctc ttcttcatca tcatagtctt 3160201 catcatcttc atcaataata tcttcttcga tctcaagatc atcgtcgtct tcatcaagat 3160261 cttcttcgtc aaaatcgtcg gcttcaagat cgagttcttc ctcaacttca tccaaatcaa 3160321 ggtcgtcttc gtcgatctct tcaaactcgt caagatcaag atcttcttcg actgctttct 3160381 tcgctttttt ctttttcgcc ttgactgtcg gctgagtttc ttcatcaagc tgatcataag 3160441 gataccagct gcgaagcccc cacgtctggt cagaaagcgc caggaagcgg ccgtcaatgt 3160501 ttaaatctgt ataaaattga gcaatgcggt ctccaagctc ttcttttttc acgccgagca 3160561 aagatgcgat ttcatttaaa agctcctgaa aaggaactgg ttttttatgt tcttcaaata 3160621 attcgtgagc gatttcaact aaagccattt cctttagctc ttcctgtgaa tattgtttga 3160681 tacccaaggt cggacactcc ctttctatta cttatatgta tctgttttat caataatgaa 3160741 agcgattttg tatcgttctt atacaaacca tacctctcat tataaacaaa ataaaacaga 3160801 atatgctacc cttaacagcg ttaatttaaa taattttaca agagtgatcc gactgagaga 3160861 tgttttccgt taatccgcga gcattctgga gatgaccagt ctttgaattt cttgagtgcc 3160921 ttcatagatt tgcgtgattt ttgcatcacg catatagcgt tctaccggat aatcttttgt 3160981 atagccgtag ccgccgaaaa tctgcacggc ttcggtcgtt accttcatcg ccgtatcccc 3161041 agccatcagt ttggacatgg cggaagcttt tccatatgga aggcccgatg attctaacca 3161101 tgcagcctga taggtcagta gccttgaagc ttctatcatt gtcgccatat ccgcgagttt 3161161 aaaagcgatg ccctgctgct cggcgatcga ttttccgaat tgctttcgct cttttgcata 3161221 ttgaagcgcc gcatcaagcg ctccttgggc gatgcctaca gcttgtgcag ctatgccgtt 3161281 tctgcctccg tcaagcgtct tcatcgcgat tttgaagcct tctccttctt ctccgagacg 3161341 ctttgatgcg ggcactacac aatcttcgaa catgatttcc gttgtcggtg aagaacggat 3161401 gcccagcttc ttttctttct tgcctgtaaa aaatccttca aaatcctttt ctactataaa 3161461 agcggtaacg ccttttttct ttttctcggg atcggtgacg gcaaaaacaa tgtaaatatc 3161521 agcaacgccg ccgtttgtga taaacacttt ggaaccattt aacacatagt catcgccgat 3161581 tcgttcagca gttgttttca tgctgccggc gtcagagcca gaccctgctt cggtcaaagc 3161641 gaatgcgccg attttctctc cgagagccag ctgtgttaag tactctgtct tctgttcctc 3161701 tgtcccaaag gcaaacagcg gccagctgca aagagagata tgggcggaaa gcgtcacacc 3161761 ggtggaggcg cacacttttg acagctcttc caccgcgatg acgtaggcta aatagtcact 3161821 tccaattccg ccgtaatctt caggccatgg aattcccgtc aggcccagat ttgccatttc 3161881 ccgaaacagc tcgcgatcga agcgttcttg ttcgtcccgt tcagccgctg tcggggccac 3161941 ctcatgcttc gcaaaatcgc gcaccaattt tcgtatcatc tcatgttctt ctgataatga 3162001 aaaattcatt gcttctcccc cattttcaga tcagcgccta aaacggattg agccagaagc 3162061 tcgacgacgt cgtacgtttt gacttggtct tcggcttcct tcgcctttgt gccgtcccca 3162121 agcatcgtga gacaatacgg acagccagaa ctgatcaccg atgggttgac tgcgagcgct 3162181 tgctctgtcc tggcgacgtt aatcctgttg cctgtttctt cctccatcca cattaatccc 3162241 ccgccggctc cgcagcacat gccggtttcc cggcttctct ccatttcaac aagctgcacg 3162301 cccggaatgg ctttcaaaat ctctctcggc ggatcataga cttcattgta ccggcccaaa 3162361 tagcacgaat catggaaggt aatcgtctca tgaagcgggt gctgcggtct taattttccg 3162421 tttttcacaa gctcggccag cacttctgta tgatgataaa cctcgccttc aaatccgaaa 3162481 tccggatatt cgtttttaaa taaattgtat gcatggggat cgatcgtaac gatttttttg 3162541 acatcatttt tttcaaattc agaaatattc ttctcagcca gctcttggaa caaaaattca 3162601 tttccgaggc ggcgcggcgt gtctcctgaa tttttttctt tattgccgag aatcgcgaag 3162661 gacacgcccg cgtgattgag cagcttggca aaggaaattg cgattttctg gcttctgttg 3162721 tcgtaagacc ccatggagcc tacccagaaa aggtactcaa attcttttcc ttcttttttc 3162781 atttctttta cagtcggaat ctcagcatcc ggcgcctcgt cacgccaatt ttcacgttcc 3162841 ttgcggttga gtccccacgg attcccttgc cgctcaatac ttgtcattgc gcgctgggcg 3162901 tcactgtcca tttttccttc tgtcagtacg aggtagcggc ggaggtcgat gattttatcc 3162961 acgtgctcat tcatgaccgg gcattgatcc tcacagttcc ggcaagtggt gcatgcccaa 3163021 atttcttcct ctgtgatgac gtcgccgatc aagcttggat tgtaatcaag cgccgctgcg 3163081 gcttcctgcg atccgctgcc cgctgacgcc gcagccagct gattgcctct cgtatgccga 3163141 aacgctgctg cgggcaccca tggggagcgc gaggtgacgg cagcgccttt ttccgtgaga 3163201 tggtctctga gacgcaaaat caagtccatc ggagaaagca tttttccggt gcctgttgca 3163261 ggacacatat tggtacagcg gccgcactcg acacacgcgt atagatcaag cagctgagac 3163321 tgtctgaaat cctcaatttt tcccgctccg tagctttctt tcgtttcgtc ggtaaaatca 3163381 attttttcaa gttttccggc agattccatt cgattgaaaa agacgtttgc cgggccggcg 3163441 attaaatggg catgctttga ctgaggcacg tacactaaaa agctaagcaa gaataggaga 3163501 tggatccacc atgcgatata gaaaatcacc gccgcgcctg ttttcccgac accgctaagc 3163561 ataaacgcaa tacctgaggc aattggctcg ctccaagaaa gcccatgctc atgccaaatc 3163621 agattcatcc cgttcccaag cagaacggtc agcattaatc ctccgataaa aatgagaacg 3163681 agtccggctt tgaaaccgcg tttcagcctc acgagctttt cgatataacg tctgtagaat 3163741 gcccacccaa cagcaattaa aatgagaaac gtaacaattt cctgaaaaaa ggtgaaggcg 3163801 ggatagaccg ggccaagcga cagattccgg ccgggagcca gtcctttgat gataaagtca 3163861 attgctccga actgaaccaa tataaatccg tagaaaaaca tgacgtgaat gattccgctt 3163921 ttcttgtcct tgagcagttt tttctgtccg aatacattca cccatatggc gtgaagccgt 3163981 tccttgaacc gttgatcaaa ttgttctttc tggccgagct tgatgtaggc cagtctcgtt 3164041 ttgaccaagt aaacaaacaa atagacagcg taagcggtta caatcagaaa taataatgca 3164101 tttgcgatga gaaagccgct cattccaatt cccccttttt actgataaag accgcgatcc 3164161 cctacccccg aatctgtata agattatctt tatgataaat aatgaatgag tgttcagtca 3164221 ataattaaat tcctgctgtt cgggcacact acctttacta cggaaaggag tgccggtatg 3164281 aaggtattta tcgtgattat gatcattgtc gttattttct ttgccttgat tctgcttgat 3164341 atcttcatgg gccgtgccgg atacagaaaa aaggcgtacg agcctgtttt ttcaaaaaag 3164401 aagagtgaca tcgaattgat ccactgcggc gctgatctcg ttgagcggat gatgaatgat 3164461 attcgccagg ccgcctcttc tgttcacatg atgtttttta ttatgaaaaa tgatgaggtc 3164521 agccacaata tgtatacctt gctgaaaaca aaagcccaag ctggcgtatc cgtttatttg 3164581 cttctggatt gggcgggctg ccgggcaatt aaaaaaacgg cgcttcagac gatgaaaaat 3164641 gccggcgtcc atgtccatgt gatgaatcgt ccccgttttc cttttttctt ttttcacatg 3164701 caaaaacgga atcaccggaa gattacggtg atagacggaa aaatcggtta tatcggcggg 3164761 tttaatatcg ccgaagaata tcttggaaag aaggcgaagt tcggcaattg ggaggattat 3164821 catctgcgca tgatcggaga aggcgtacat gatcttcaaa cgctttttgc ttctgatcta 3164881 aaacgaaata ccggaatcga actgggttcg gatgtttggc caaagcttca gcaagggact 3164941 atttctcaca agatctatgc gaccgacggt tattcccttg aaaacatata cttggccaac 3165001 attgcccaag cgaagaatcg ccttacggtt tgcacgcctt attacattcc atcaaaaccg 3165061 cttcaagagg cccttattaa cgcaagaaaa aacggcgtat ccgtgagaat cattgtaccg 3165121 atgaaatcag accatccgct ggtacgagaa gcggctttta cgtattattc ggagctcttg 3165181 gatgccggct gtcttattta tcgttattat caagggtttt atcatgtaaa agccctcatc 3165241 atagacgacc atctcagcat tatcggaaca gccaacttcg ataaacggag cctgttctta 3165301 aatgaagagg tgaatgttga aattgatgac gaagcgttta caagtgaagt ctatgccaca 3165361 attgaggagg atatgaaaaa gtcggagctg ctgacgatgg aggatttcag caagcgcaca 3165421 ttcaggcagc gcccggcgga atggctcggc agggcattat cttatttctt ataaaggaga 3165481 gttcctatga ttttcagatt cgggttcgtt tcaaatgcga tgagcctttg ggatgcgtct 3165541 cccgctaaaa cattgacatt cgcgcgttat tcaaagcttt caaagactga aagaaaagaa 3165601 gcgcttctga ctgtgacaaa agccaatttg cgcaatacga tgagaaccct tcactatatc 3165661 atcggccacg gcattccttt gtaccgtttt tccagttcga ttgtgccgct ggctacgcat 3165721 cccgacgtga tgtgggattt tgtaacaccg tttcaaaaag agtttcggga gattggagag 3165781 cttgttaaaa cccatcaact gcgaacaagc tttcatccaa atcaattcac tctgtttacg 3165841 agcccgaagg aatccgtcac aaaaaatgcg gtaacagata tggcgtatca ctaccgcatg 3165901 cttgaggcca tgggcattgc tgatcgctcc gttatcaaca ttcatattgg cggcgcttac 3165961 ggaaataaag acaccgccac tgcacaattt catcaaaata taaaacagct gccgcaggag 3166021 atcaaagagc ggatgacact tgaaaatgat gataaaacat atacaacgga agaaacgctt 3166081 caggtctgtg agcaggagga tgttccgttt gtctttgact ttcatcattt ttacgccaat 3166141 ccagacgatc acgccgacct gaatgtagca ctgccccgca tgatcaaaac gtgggagcgg 3166201 atcggccttc agccaaaggt tcacttgtct tccccaaaat cggagcaagc gatacgcagc 3166261 cacgccgatt atgttgacgc caactttttg ctgccactgt tggaacgctt taggcaatgg 3166321 ggaactaata ttgatttcat gattgaagca aagcagaaag acaaggcgct tctccgcttg 3166381 atggatgaat taagctccat ccgcggtgtc aaacgcatcg ggggcggtgc gctgcaatgg 3166441 aagtcataaa tgtgcaaaaa taggtttacg acttgtcagc tttgggaact taggctatat 3166501 aagacaacaa tcgatggagg agaaagatca tgaaaaatat caagtctctg aaagtagccg 3166561 cacaggcctt tactttaaga aatttgattc atctttataa aatgtgccat tccggaagcc 3166621 acgaggttta tatttattca aagaaaacga tgtgcaaaat caaaagctta attgagcttg 3166681 aaacgttccg catggctcat aatgaaaagg aatatctgat cgtagttgaa ggaacaaaag 3166741 catcacagct cattgaaaaa ttccaaaatc tcatcgagcc tgctgagaga gaagcgctct 3166801 aacttacata caaaaaagga tagacatctg tctatccttt ttcttatgct cttacataat 3166861 ggagctgaac cgcttgtcca aattgttttg tcccttttaa ccgcagtttt gtttcatttg 3166921 ttagttcgtg aaacagcggg atgccgcttc ctaaaacgac gggaataaca gtgatgatga 3166981 attcgtcgat ggcatcttct ttcataaagt cattcacaag ctctgccccg ccagctatcc 3167041 agatgtttga gcctttttcc tgtttcaaac gggcagtgaa ggctctggct ccctcattga 3167101 taaacgtcac atgttcatct tgataactgt cgggcgatcc tgtaaaaaca tagcaggttt 3167161 tatcctgata cgggaaaacc ggtgttagca ctttaacgtg ctcatatgtg ctccgcccta 3167221 aaatgactgt atcaacagtc tgataaaaat cactgtagcc gttgtcacct tcaccttcaa 3167281 attcatccag ccaatcgatg cttccatctt cttttgcgat catcccgtcc aatgaaacag 3167341 caatgtacag cacagttttt ctttccatgt tctcctccta tcgatgcacc atttgcccga 3167401 attgcgcttg atgcagcctg ctgtataggc ctccggcttc gatcaggtct tgatgacggc 3167461 cttgttcttc aataccgttg tttgtgacga ctacaattct gtccgcgtct ttgattgttg 3167521 ccagcctgtg ggcgatgaca agcgtcgtgc gcccctcaga caactcttga agcgcctttt 3167581 ggatcgccgc ttccgtctct gtatcaaggg ctgaggtggc ttcgtcgaga atcaagatcg 3167641 acggattttt caagaacatc cttgcaattg acagacgctg tttttgcccg ccggaaagct 3167701 tcacgccgcg ttcgccaatc atagtatcca acccatcggg catgttatgg acgagctctt 3167761 ccagatgcgc ctgcttcaca gcttgccaaa tgtcttcttc tgatgcgcct agtcggccgt 3167821 aggcgatatt ttctctaagc gtgcccgaga ataagaaaac gtcctgctgc acgacgccaa 3167881 tctgcccgcg caacgaagaa agcgtcatgt cttttatact gatgccgtca atcgtaatgt 3167941 cgccctccga tgcttcataa aaacgcggaa gcagactgca aagcgttgat ttcccagcac 3168001 ctgacggacc gacgaacgcc accgtttccc ccgcttgaat ggataggttg atgtcattga 3168061 ggacattgtg atggtcatca tagccaaacg aaacatgttt atagcggata ttgcccttca 3168121 ggccggaaac atctttcgaa tcaggtgagt cctgaatatc cggctctgtc tccatgagct 3168181 ccatatagct tttgaaaccc gcgatccccc tcggatacat ttcgataatg gcattaattt 3168241 tgtcaatagg cctgaacagc acattcgtca agagtacaaa cgccacaaat tccccgtacg 3168301 ataaggagcc gcgaatgaca aaccacgtcc cgcacaaaag gacaaacagc gtgacaaacc 3168361 gggtcagcat atagctgatt gaaccgtttt tcgccatgat tttgtaggaa gaaagctttg 3168421 tgacacgaaa acgctggttg ttgacggcga agcgttcttt ttcaaatgct tcatttccga 3168481 acgcctgcac aagccggatg ccgccgatgt tattttctac acgcgcgctg aagtctccga 3168541 tatccttgtt cagcgtggta aatgctttgg tcattttttt gttgaaataa agcgctagcc 3168601 aaatgacgat cggcataatg ataaacgtta ataaagcaag ctgccagtta ataaacagca 3168661 tcactccgaa cgccccgaga atggtcatga ccgcaatgaa taagtcttcc ggtccgtgat 3168721 gggcgacttc accgatatac attaaatcgt tcgtgagctt cgacatcagc gttcccgtct 3168781 tgttgttgtc gtaaaatttg aacgagagct tttgcaaatg gtcaaaaagc gactttctca 3168841 tatcagtctc aatattgata ccaagcatgt gtccccagta ggtcacgata tactgaagag 3168901 ccgagctgag cgcgtacacc gcaaataacc cgattgaggt cgcgatgatc agtccccagt 3168961 ccctgcccgg cagcaaggta tcaataaaat aattgacgat caaaggaaaa ctcagctcca 3169021 ttaaacctcc cgcgatcgct gagaaaaagt cgagaaagaa caacgtttta tatggtttat 3169081 aatatgaaaa aaattgccgc agcaccctat cttcccccaa tgtataaata actgataata 3169141 tttctcaatt atactataca cgggctgttt tgtaagatca gatttctttt ttcttacaga 3169201 acacctgaaa acaggcgggc aaacgactct tttgtccggt cagccacacc tcttttataa 3169261 aagccgacag ggctgagctt ttcactttcc tgcatatcct cttcaaaatg ggcctcaagg 3169321 gttcggatcg cttcggcatc cgtgaagaac acattcactt caaagttgag ctgaaagctg 3169381 cgcatgtcca tattcgcggt accgacggag gcgagatcgc catcaatgat catgactttt 3169441 tgatgcatga agcctttttg gtaggagtac acttcaatgc cctcaaggag cagctccggg 3169501 aaataggacc tcgacgcgta ttgggtcaaa aagctgtcgt tcttctccgg caccataacc 3169561 cttacctcta ccccctttgt cgccgctgct tttagcgccg tgcgaatgga ttcattgggg 3169621 acaaaatagg gcgtggcgat ccatattgat ttctgcgctg aagaaatcat ttcataataa 3169681 aggtcgctca tgctttcctt catgtcaggg cctgtcgcga caatttgata aatgcctcct 3169741 ccttccacgg gaaccggggt attgtactcc tcttgatcaa ttagcacttc attggagaca 3169801 tattcccaat ccagcataaa gatagcgtgg agcgtttgca caatttcccc ctcaagccgc 3169861 aggtgtgtat ctctccaaaa tccgatgtac ggatctctgc tgatatattc cttcccgaca 3169921 tttaatccac ccacaaaacc ggttttccca tcgatgatca cgattttccg gtgatttctg 3169981 aaattcagct tctggttgaa aaacccgtat ttcagcggag aaaacgggac gatgtccacc 3170041 cccgcttgtt tcattctcat aatatctctt cttgccagct tcatgcttcc tgccgcatcg 3170101 tataaaaacc tcacctcgac accctggcgc gctttctcca tcataatatc catcatgccg 3170161 cgtccgagca tgtctgattt aaacatgtag tattcaatat gtatgtaaga ttccgctttt 3170221 ctcattgctt tgaaaatgtc cgggaaggtt tcttcgccgt ttttcagcac tttgatgttg 3170281 cttttcgtat tgatattcat atgggcagcc ctgatggaat atgtaaagaa cctctcttga 3170341 ttgtccttca gccctgtcac ttcgggcgtt tcctccttgt caaacagctt cctgagcttt 3170401 tccctgttgt acattcgttt tgtcttaaac agctttccct ttacataaag ctgtcccgaa 3170461 aacagataaa acacgtagcc gacgattgga aaaaagacaa gaatatggat ccatagcagc 3170521 gtgtgctgcg aggtgcggtt ttcaagaatt aatgaataga tgctgaacaa aataatgctt 3170581 atatagcaaa gcaatcctcc gtaaaactca agtctggaaa ccggaaaaaa ccaaatgaca 3170641 tatgccccga tgagcatcat atataaaaag aaaaattcca gtctcctttt cagcatcctg 3170701 attctctcca atctgattca attacctctg tattacctct tttttctaat cgataaacct 3170761 tgtaagtaaa aaacctctcc gccaaaggag gagaggttta gagaaaacta actgtcacgg 3170821 aattcatccg catcgtttct gcagaaataa agcaagacta ttggcaacgc cgagtgacaa 3170881 catgagcggc aagctgaacc cgctcagcac tccggcaagc gccgaaaaga aggcggcgct 3170941 gtgactgcaa atacggtgga tagagtaaat ttgataccca ttctgatgag agaaaatata 3171001 taaaacggga aattgatcag aaagatataa ggagttagtc aggctgaatc ataatctggc 3171061 tgttccgccg gtttaaaatg agtaaaatcc ttgatgttat ttccatatac aaacataaca 3171121 ggattcccgg cagcccagcc attaccttgg cagaaaaaac cccctcttgc aagggggatt 3171181 ttcacgagcg tttccgatat acaacgtagc tgcgggtcag atacttgagc ggcagactga 3171241 acacatgaac caatctcgta aacggccaca ggataaaaac gacgtatcct atcacaatat 3171301 gaaacttaaa ccatagcggg acactctcca tcaaagaggc gtcaggcctg aacaaaacga 3171361 tttccctgaa ccagggcccg actgtggtcc ggtaatcaaa tcctttcgaa tcaatgttga 3171421 gaaacgtggc cgcaacgcct gacagcatca tgaacagcag caggaggagc gtaaggatat 3171481 cggatggcga gctcgttttg cggattcttt tgtcaaacag ccttctgtac gtcaggatga 3171541 caagtccggt acatgccgca atgcccgccg gcaagccagc gccaatcgcc attttgtgat 3171601 acatatgctc tgaaatgcca agggaagcat acacgccttc tgggatcaga atccccatga 3171661 catgcccgcc gacaacgcac agcagtcccc agtgaaaaag tgtgctgcca gccgcaagtt 3171721 ttttcttttc taacagctcg cttgatttcg ccgtccagcc aaattggtca tgctgatagc 3171781 ggtaaatatg gccgccgata aagattgtca atacaatgta tggcataata ccccagagga 3171841 tctgcccgct catgcctgaa cagccccttc aacgctttca cgtacgccaa tgttttcaag 3171901 cgcggccagc agcacgtgca gcagttcagc gtatatactg tcattttttt cgagacggga 3171961 tgccagctcc ctcacattgg acagatattt ctcaaacacg cttctcgctg cttcaatttc 3172021 tgcagccgca gcaaattcca gcatcagcgg cagataatca ggcagctctt tctctgtcgg 3172081 caggaaaccg gattgctcgt atgtgttttt taaatgcagc aattcaatgc cgcgttccct 3172141 ttgctcgcct gagttaaagt aggtgacata catatttgtt tttttcccga agtcgaatgt 3172201 atagacatag tgttcaatca gcgcttccgg agaatagctg gctgacgtct cgaaaaagtg 3172261 cagcagcttc tcccggattt gccggttgcc gatttcttgg ataagagcct tccaatcggg 3172321 aagctcggct ctccactctt catccggata agagagaaga caggaaagag cagagaacgt 3172381 gatttgccgg tctgtggtgt tcatcttgtt acacctcatt tatcaaaagt tagaaacagg 3172441 agccggggcc gcctgaaaat gataagccgc agcttccttg ttcagcgtat aaatctgata 3172501 cttcttctcg atggctgctc ggaatcacaa agcggtcatc atatttggca atcgcaagca 3172561 gccgatacat atcttcaatt tgctgttctg ttaagccgac actggagatc agttccggat 3172621 cgattgattt attcgtctgg accgctctca tatactggcg catgacagac attttcttta 3172681 atgttgaccg aatatgatcc gtatcaccgg ctgttaacag ctgcgccaaa taatctatcg 3172741 ggattctcat ttggtcgata gccggaaaaa tatcttccgc cgtttgccgg ctgccttttc 3172801 cttcaaagag attcataatc gggctgagcg gcggaatgta ccacaccatt ggcagcgtgc 3172861 ggtactcagg atgaagcggc agcgcgatct tccagtcaat gatcatttta tagatcggtg 3172921 attgctgcgc ggcctctatc cattcagccg gaatgccttg ttcttttgcc agtttggcaa 3172981 cctcaggatc attcggatca agaaaaacgt ccaattggga atggtagaga tccttttcat 3173041 tttcaacaga tgccgcttcc tccactttgt ccgcgtcata tagcatgacg ccgaggtagc 3173101 ggattctgcc aacacacgtc tcagagcaga tggttggcag tcccgcctcc aaacgcggaa 3173161 agcagagtgt gcatttttcc gctttgttcg tttgccagtt aaaatagact tttttataag 3173221 gacaggatga gacgcaatat ctccatgaac ggcatgcgtt ttgatccaca agcacaatgc 3173281 cgtcctcctc gcgtttgtac atggcgccgg atggacagga tgagacgcat gccgggttga 3173341 tgcagtgctc gcaaatacgg ggcaaataca tcataaagac gtcatcgaat tctgttttga 3173401 tcgattcctc catcttttgt acgttgggat cttcaagtcc cgtaatgtgg ccgcctgcga 3173461 gatcgtcctc ccagttcggt ccccattcga tattcatgaa atcccccgtc aaggacgatt 3173521 tcgggcgtgc taccggctgg tgttttttct gcgggctgtt cgttaatgtt tcataatcat 3173581 agttccaagg ttcatagtaa tcatcaattg acggctgatt cggattatag aaaaggcctg 3173641 caagccgatt ggttttcgag cccgatttca gctcgagctt tccttttttc aatgtccagc 3173701 cgcctttata tttgtcctgg tcctcccatt gcttcgggta gccgatgccc ggctttgttt 3173761 ctacattatt gaagtacata tattccgcac cggaacggtt tgtccacgtg tttttgcagg 3173821 tgacgctgca cgtgtggcag ccgatgcatt tatccaagtt catgaccata ccgatttgcg 3173881 ctttaatctt caagccaatc gacctccttc agcttgcgga tgacgacgtt caggtcgcgc 3173941 tgattccccg ttggaccgta ataattaaag ccgtagctga gctgggcgta gccaccgatc 3174001 atctgtgtcg gcttgacgtg aatccttgtc gggctgttat gggtgcctcc gcggttattc 3174061 gtcagctttg tgccgggcac gttgatgtgg cggtcctggg catggtgcat aaacgccatt 3174121 cctttaggaa tccgatgaga caaaacggct ctcgcgacga caacgccgtt tcggttgaag 3174181 cattcaatcc aatcgttgtc tttgatatcc gtgtcctctg catcatcttt attcatccac 3174241 acggtcggcc cgccgcggaa cagcgtcagc atcggcagag aatcaaaata catgctgtgg 3174301 acagaccatt tattatgcgg cgtcaaataa ttgaggacga tttcttttcc ctcttgatca 3174361 ggccgtttgc tcagaaacgg gcgatgctgg aggatcggtt tgaatgtcgc catcgtttca 3174421 ccgaattcca tcatcagttc atgatcgaca taataggatt gtctgcctgt cagcgtccgc 3174481 cacggaatta atttttcaac attcgttgta aacggcgaat acctgcgccc tcctttttca 3174541 gagccggtaa acgctggaga cgtgatcacc gttttcggct gggctgtaat ttgttcgaac 3174601 gtaaagcatt cttcctcgcg ttcttccgcc aggtctttca gcttcaggtt cgtgatgttt 3174661 tcaagtgatt cccatgcttt tactgcgacc tttccattcg aagtggatga tagggttaaa 3174721 atcgcttctg cagcctgctt tgcttcactt atatttggac atccctttgc cacgctgtcc 3174781 gaggtgattt ctcccagtct ctgtttgagt gattcatatt catcggctat tgaccagctc 3174841 atcccttttg ttccgctcgg ctttaaagca acgttcggac caagtgcagt cattttatga 3174901 aaaatgtgtt tgtaatcccg ttcaacgact tggatgttcg gcatcgtttt tcccggaatg 3174961 gcttcacatt cgcctttgct ccagtcattg attttgccga atggctgggc caattcctgc 3175021 atggtgtcgt ggagcagcgg tgtcgcaacc acttctttca ccggctccat atcgacttct 3175081 tctgccagat cggaaacggc ttttgacagc gccttgaaaa tatcccagtc tgacttcgat 3175141 tcccacggag ccgagatcgc aggagcaaat ggatgaatga acggatgcat atctgtgctg 3175201 ctgagatcgt gtttttcata ccatgtcgcc gccggcagca cgatatcgga atacagcgcc 3175261 gtacccgcca ttcgaaaatc aagattgatt aataagtcga gctttccttc cggcgcctgc 3175321 tcccgccatt tgatttcttc tgggcggatg ctgtcgctgt cgtcattcat taaaccgttc 3175381 gttgtcccca gcaaatgctt gagaaaatat tcatgccctt ttcctgagct tgagatcaga 3175441 tttgcccgcc atacaaagag attccttggg aaattcactt cattgtcagg atcttcaatc 3175501 gcgaatttca gttttttctc ttggagctgt gaggccacgt acgcacctac gtcttcaggt 3175561 gttgctgccc ctgctttttc agcttcttta tacagatcga tgccattttg attgaaagtc 3175621 gggtaagacg gaagccaccc tagccgcgcc gccagcacat tgtaatcagc gtggtgcttg 3175681 tagcgggatg aagcagcaat cggtgatgcc aaatcactga tcggctggtc ctcataacgc 3175741 cactgatctg tcgcaaagta gaaaaatgag gtgccatttt gcagcttggg cacgccttcc 3175801 cagtcctttg cagttgcaat cgtctgccac ccttcagcag gtcggagctt ttcctgcccc 3175861 acgtaatggg cccagcctcc gccgtttacg ccttgggcgc ctacaagtaa aacaagattt 3175921 aacactgctc ggtagatcgt gtcggagttg aaccagtggt taatgccggc ccctacgata 3175981 atcatggacc ggccgtctgt atcgatcgca ttttgggcaa actctctggc aatcttaacg 3176041 acagcttctt ttttgattcc tgtcatttgt tcctgccagg caggcgtaaa cggctcaggg 3176101 tcatcatagg agacagccga tcgttcgccg atgccccggt tcacgccgta gttagccagt 3176161 atcaagtcaa acacggtcgt gatgtacgtt tcttcaccgt tcaggttcat ttttttaata 3176221 ggaagatccc gctcgagcac tttgtttccg tcatttgaaa aatacgggat gcgcaccgtg 3176281 ccgatttcgt cctctattcc cagcacagag agacggggtt caatcggttc cccggtttct 3176341 tcatcaatca tgtgcaggtt ccatttctgc tgcccgtccc agcgcgagcc cattgtccct 3176401 tggggtatgg caaatgaact tgtctgttca tcccaaaccg caggcttcca ctgatcatgc 3176461 tttgtcttcc gcccgatgtc cttcgcatgc agaaaccgtc ccgctgtgta tacgccattt 3176521 tcttttgaca gagtgacgag aaatggaaaa tcagtgtatt gcttcgcgta ctcaataaaa 3176581 cgttcagttt cttggttcac gtaaaattcc tgcagaataa cgtgacccat cgccatcgca 3176641 agcgccccgt cagtcccttg gcgaatactc agccagtcat ccgcgaactt tgaggattcc 3176701 gcaaaatctg gactgatcga aatgacctta gcgcctttat agcgggcctc cgccaaaaaa 3176761 tgcgcgtcag gcgttctcgt taacggaacg ttggagcccc atgtgataat atagccggaa 3176821 ttgtaccaat cactgctttc cggaacgtcc gtctggtcac cccaaatttg cggggatgct 3176881 ggaggaagat ccgcatacca gtcataaaaa ctgagcatag ggcctccgat taacgacata 3176941 aaccgggagc ctgatgcgtg gctgatcatg gacatggccg gaatcggaga aaaaccgacg 3177001 tttcggtcag gcccgtattt catcactgta tacagcagag aggctgaaat cagcttcagc 3177061 acctccggcc attcagcgcg cacaaaaccg cctttccctc tcgcctgttt ataggacttc 3177121 gctttttcag ggttttcgac gatcgatttc caggcttcca atggattttg atgcgtctgc 3177181 aatgcctccc gccacaaatt gatcagcaca ccgcgcacgt atggatattt cacacggagc 3177241 gggctgtaga tataccatga aaaactggcc ccccgcgggc agcctctcgg ttcaaaatca 3177301 ggcatatccg ggcctgttga tggataattc aaattttgcc cttcccacgt gactattccg 3177361 tttttcacat aaatattcca gctgcaagac cctgtacagt tgacgccgtg ggtggagcga 3177421 acgactttgt cgtactgcca tctgtttctg tatacattct cccaatcgcg atcctcgcgg 3177481 gtagtttggc tatgtttatt tgaatggtgt tcgataggag agaaataatt caatctccta 3177541 aacaacggac tccttttctt tttcttcatg agagttcact ccttccgagt caggtgatgc 3177601 taagttcact ataaacagag acagcgtgtt tccttgtgaa ctatgtcaca cactctgctt 3177661 ttttcacaaa atgttcacac aaaggagaag gaaggctgcg ttcaggcagg acgcttgggt 3177721 cattagctgc ctttcattca aagatcaaaa aaaaccggct ctatttaaga accgggctca 3177781 gcgttttcat cctgtgatgt atgcagatac cgcaaaaata attgatagga acaaaaaaca 3177841 ttttgctgaa gcatagccaa aaagttcatt tgcagctgcg gatgataaga catcattttc 3177901 ttaaatatgt aatatgggat gttgagaatc agaatgtctg aagtggcatt gactgagata 3177961 aagggcgata aataaagccc gcctttttca tcaatcggaa acacatcgcc tttttcccac 3178021 agcgcaacgg ttttcgaccc ttcagggagc cttgtgtcca taaaacggac actgcctttt 3178081 aatacaatat aaacagattg agaatgaaga aaagatggag actgatcaca tgaaccgcgg 3178141 ataaacgtgc cgtttttcag caaggtttcg acaatggata gaggcacttc attaaacata 3178201 ggaagttgtt tcagaaataa taaatagtca cactgattca taggaaaacc tcctgtgcta 3178261 aggatagctt tagtgtagct cgactgagcc tgtacagcag tgatgtattt cacagcctgt 3178321 atgatgaatg tcacttatca ggagggtgaa tgcatttata atgaaagaaa aaaggaggat 3178381 ttcgatgaag gcgctgattc cgaagcagca cggggcgtgg gcgatgctgc tgatcccatt 3178441 tttactcggc atggtcaagg gaggccccgt tatttggcat attccgctct tccttggttg 3178501 gcttttccta tacttagcgg tttatcccgt tacgcttgcc ttaaaaaaga aacaaagcaa 3178561 accatatcaa aagtggatgt gttattacgg ttttcccacc tgctgctttt tgatgatctc 3178621 ggtctttcat aagccgcctc tcatctgggt gggcgtttct ttactgccgc tgtttctcat 3178681 acatatgtat tttgcccgca gaaaaaacga acgagcctta ttgaatgatg ttgcaggtgt 3178741 cttgttcttt tgttcgggcg ggtttgcgag ctgctggctg gggatgggaa cccttgacgg 3178801 ctgggcttgg tttattttct tgcagtctgc tttatttttt atcgggagtt ccttttatgt 3178861 gaaatcggtg atccgcgaga gaaaaaacag ggcatttgca tactggtcat ggggatatca 3178921 cctgctgctc ccctttttat ccgctctttt cggagcagga tgggcgtttc tcgcttttat 3178981 cccgagcagc ttgcgggcat ggttttttca tggaagggat tggcccgtaa aaacgattgg 3179041 cattctggaa atcgtgaatg cctgcttctt tcttgccgtc atgtgcctgt ttatcacaag 3179101 gtaaaaaaac aaggacaccg ctgtccttgt ttttttcagt caatattgca aatctccagc 3179161 gggcaatttt cacactcaat ctcacatcgt aaatagtccc gcttgtgcaa aataattttt 3179221 ccggattcgt ctatcgaaat aacccctttt ttgcggagat ctccgagcat acgattgacg 3179281 ctttcccgtg cagccgcgca aaactttgcc aaatcctgat ttgtcaggac aatgttaatc 3179341 agaatgccgt cgcttcgctc cactccgtag ctgtttgata agcggataag ggtagaatag 3179401 agcgccccct ttttgccatg aagaagcaga tccctgattt tggactgaat cttccggagg 3179461 tgcgtgctca tccatttcat gaactcaaat gtcaaagcgc cgttttggat taattctttt 3179521 tccagcttat ttttattaat gacgagcacc tcgccatcct ctagtacttt tgcactgagc 3179581 atataccttg gttcttcagt gaaaagtgtt aattctccga cgatatcatg cttttggcag 3179641 attctaagcg tcaggtcttt tccgtcagat gtcagcttgc cgatttcaat gagtcctgat 3179701 tgaatcagat aaagctcttc tgcatccatt ccttcccgaa acaaatacgt gtgtttttcc 3179761 atttttcttt tcgtgctgat cgattccagc aattcataca gatcgctgga tataagatca 3179821 ctatcagatg gtcgaacaga gagaaaattc atgagctcac ctcgaagaaa gtcacgttgt 3179881 gtgtttattg taacgtgaat tgatttgtac ccatcgagaa aaaactaaca atcttgtgaa 3179941 tgccccagtg ttagttgatg ctctggctgt ttctctccgt gtgtgttttc attctttcct 3180001 gccaatacat ccatatgaca aggacaaaac tggctaacgc cacctctgaa agcgccataa 3180061 acccgatcgc gtactggcct gttgcctgaa atacactcgc caatatgagc ggaggaaaaa 3180121 agccgcctaa accgcccatg gcagacacaa tcccattggc aatccccgct tgcttcgaaa 3180181 aatagaaagg caccagttta aaaacagttc cgtttcctat gcctgagcag acggccacgg 3180241 ttaatgatcc aaacgtataa aggccgattg tcggcgagaa cgataggata atgcctgata 3180301 atgtaagccc ggcaaaaaca aacatcaaga tgcggagcgg gctcatttta tcagccagga 3180361 atccgcccgc aggcctgagc agcgtagaaa ccgcaataaa gccagccgtc cgcaagccgg 3180421 catctgcagg attcagccca aaatgctcca ccagaaagtt cggcagatag atagtgaagg 3180481 cgacaaaggc accgaacgta ataaaataaa acaggctcag aaaccatagc acatgatttc 3180541 ggtaaacagc tttgatttga gtcttaacag aaactttgac cttcttctca tgcctgtcgc 3180601 caaacaatac gtgcagtaag gcaaagacag ccagcaaaat cagatacatt tgcacggttg 3180661 atttccaccc gacggcttga gcgataaccg gcgctgcaaa tgtcgtaacg gctgtcccga 3180721 tatttcctgc accgtaaatc ccattgacga caccgtgctt ttctttcgga taatatttcg 3180781 ggagggaggt caccccaatg gaaaacaccg ctcccccgat ccctaagaaa aagccgcctg 3180841 cgattaaatc aaacagagaa tccgcgatac tgatccaaaa tacaggaaat aaaagcagga 3180901 tgaagctgac cataaacatg agccgcgcgc caaacctgtt cgttaaatac cctaaaggaa 3180961 tgcggagaag cgacccgagg atcacaggaa tcgcggtcac taaagaaatc tcacccttgc 3181021 ttaaatgaat atctaatgtg atttgggaaa tgagtgatga aatcagcacc caaaccataa 3181081 accctgccac caagcttaat gactgtaacg ataattgaat gtgttgacgg ttgatcattt 3181141 ggcttgcccc tttcaatgat tcaataatca gtcttatcat acaaaaacta gccaaacagg 3181201 attgtgaatt acatcacacg tttttctcat aaaaaaagga caaagcccga agactttgtc 3181261 cttttgatcg tgattacatt ttttccggag ccgatacgcc gatcagctga agcgcattgt 3181321 tcagcgtaat ttgcgttgcc ttcattaaag ccaggcgcgc gcggcttttc tcttcatttt 3181381 cagggtcgat gactttctct gcgttgtaga agctgtgcag agcagaagcc agatcataaa 3181441 tatagttagt gacacggtgc ggaattcgtt tttccgctgc ttccgccact gcctctggga 3181501 agccgccgat cgttttcagc agatcgtatt ctttttctga ttgaatatgg ctgaaatcaa 3181561 gatctgccgc cggtttaagc ccctgctctt ccccttggcg aagcatgctg caaatacggg 3181621 catgcgcgta ttgtgcataa tacacagggt tttcgttaga tgttgataca gcaagatcta 3181681 agtcaaaatc catatgggtg tctgcacttc gcattgcaaa gaagtaacgc acggcatcca 3181741 agccgacttc ttcaatcagg tcacgcatcg ttacggcttt accggtccgt ttgctcattt 3181801 tcattttctc gccgtttttg taaaggtgaa cgagctgaat gatttctact tcaagcgttc 3181861 ctttttcata gcccagcgct tcgattgccg ctttcatacg cgggatgtag ccgtggtgat 3181921 cggcgcccca aacgttgatc agcttatcaa agccgcggtc aagcttgtcc ttatgatacg 3181981 cgatatcagg aagaaggtac gtgtacgtgc cgtccttctt gatcaatacg cggtctttat 3182041 catcgccgaa agtcgtggaa cggaaccaag tcgcgccgtc ttcttcatag acgtggcctt 3182101 tttcgcggag cgcttcaagc gccttgtcga tttttccatt ttggtacagt gaagtttctg 3182161 aataccacac atcaaacggc acacggaagt tttccaagtc cttgcgaagc ttttccagct 3182221 cgtatttcag gccgtattca cggaaaaacg cgaggcgttc actttcctct tcgttaacga 3182281 aacgatcacc gtattcctca gcgagacgct ttccgatcgc aatgatatcc tcaccgcggt 3182341 agccatcctc cggcatcggt ttttccaatc cgagtgcttc aaagtaacgg acttcaacag 3182401 aaagcgccag attgttgatt tggtttcccg catcgttaat gtagtattcg cggcttacat 3182461 cgtaacccgc ttttgaaagc acgttgcaca aggaatcgcc gacagccgcc ccgcgcgcat 3182521 gcccgaggtg aaggtctccc gtcggattcg ctgatacgaa ttctacctga actcgttcac 3182581 cgtttccgat gttcgtttcc ccgtatgctt cccctgcttc cagtacagac ggaatcagct 3182641 ttgttaaata ttgattgttc atatagaaat tgataaaacc cgggccggcg atatccagtt 3182701 tttcaatcga agccttccct ttatcaaaat gggcgacaat ctcttcagcg atttgacgcg 3182761 gcgctttttt tgccactctt gccaactgca tcgccatatt cgttgagtag tcgccgtgtg 3182821 ttttatcttt cggtgtttct aaaacaacat tgggaatctg gctttcttca gccagtcccg 3182881 ctttcagaac ggccgctttg atttcttctt tcagcacgtc cttcatttgt tccgcaatgt 3182941 tcatgcgtga gttcctccct catacgtgat cgtcatatta tgtaaatgct cctgctcgtc 3183001 tccgacatgc atgtcatatg cgatgctgat acggcctttt tcttcatcga gatcagattg 3183061 aatcgatttt gtgcttgttt tcagctcaag ctcaccaaat gacattttat atttagcaat 3183121 tgtggaagct cccgttacga aacgctgatt cattttgaca gcgcctgacc tcatgaccag 3183181 gacttcgcct tcgcttactt tcacaatcgt tttgactttg cctaagtcgt gttcttcata 3183241 ataagataga tacactttat tttgttttac atagtaaaat ccggtggtgc ggaattcgat 3183301 gacttcttgg tttccgtcat cctcgatcac agacttcaca tggagtgtta tcggtgtctc 3183361 ttgcttcatt ctgacacgtc cttttcatca ttccactttg acttgaatag tataatcatt 3183421 cggtttgtaa acttcaactg cttctatctt accatcattg ctcatcagat ttgaagataa 3183481 acctcataaa aagcatttcc ttatatagaa gagaaaatca tatcactaat tacctttagg 3183541 aaatgttacg agctcgctac atcgcaatcg cagacggacc cgcgccaacc ggaatcaccg 3183601 tcacggctgt ataatcactt gtgcggtaca cggtcacagc attgtcgttg ggctgtgccg 3183661 cataaatata ctgtttgtcc ggcgttacgg cgaggtcaaa ggcgccgggg agagacacgt 3183721 ttgcaatgat cctctgtctg gccgtattaa ctacgtataa gttattaatg agaaacggtt 3183781 cactatatgg ctctagaaaa taagctctag tactatcgag agaaaataca atcgtcctca 3183841 gcgtttcaaa taaacggctg aagtcccctc ccctgcttaa tggtgacaaa ctaatctccg 3183901 ttacaccttt cggccacagc tcaccattca atacgtacgc aaaatttcca gcgtaaggag 3183961 ttgtaattaa actgggaaat tcaaatgtat ctatgatact ttctaccaac tgcccagtat 3184021 ttacatcata tttatcaacc gaccaactgc ttccattagc ggtatagaca tactgtccat 3184081 tcggatcaag agcaaagtct aaagcgccgg gtatcggaat gacatcaatg accgattgag 3184141 aggccgtgtt aatcacatat atagatccgg cggccatcac gtatgcgaac tcatctgttg 3184201 gatcaaattc gatttttctc ggccctcctc caacagtaat ggtatttatg atggttaatg 3184261 ttttattatc aatcactgag acaaggttgg tatttccatg gaggacatac gtgaatgctt 3184321 tatcgaaagt aacgcctaga ttagttggca cgtcagaaaa agggattgtt tttacaacag 3184381 tgtttaaatc tgcatcaata accgaaaccg tgctgtctcc agtattggca gtaaacacat 3184441 acgattgagg gtctggtgat ggcggtaaaa caagtgtccc ggccaccgta agcggactgc 3184501 cgtagaaagg cggtacaatg agcagatctt ccactgttat ttgactgaaa tcaggacagc 3184561 ggccagactg tgctgcataa taaacaactt gatcaatctc ttcagtatga atcacagaaa 3184621 cagccccgtc tccttgtcca tattgatttc gtacaggcga cacactgaca agaagcgtaa 3184681 tggtcccttg tactctcaca gcatatcgaa caccgatatc ttctggttcc ggcccagtct 3184741 ggattaagca aggctcactg atacaggaca aattgtctgt actccatgta acagccgctg 3184801 acgcttcggc cgtatcaacc ttgaagccct cagggaaatc tatcggcact tgaaacggcg 3184861 cttcccggct aatttcctca tcacaaaaac agaaacaatt ttcctgtaaa gcagaaagat 3184921 cattcttttt catgatttca cgtcctttta gaaatgcaca acatgcagcg gttaaatcgt 3184981 aatggcaccc ggtgaaaccc caagagatat cacagtttcc tcagaataat catctgtgtt 3185041 gtaaacaatg atgctctgct ctataaaacg agttgcatac agaaaatcgc cattcggggt 3185101 aaacgcatag tctgttgctg attgcggaac atttcctata acgcctgctc catttggact 3185161 gacagaatat aaattgccag tgaagccgtc atataaatac acctctgctc cactcgtaaa 3185221 cattcgatat tccccttcat actccagctc ttgggtgctg ctgatggtaa acgtatttaa 3185281 atcaataacc gtcaaataat taaaaaagaa ttcttgttct aatacatagg cataccgctc 3185341 cggccaattt gtttctatgg ttgatacgat aagctctcgt tcaattgttc ctgtgacttc 3185401 accggtagtt aggtccactt tttgcactat tccaaaattc agaacatagg cgaataaccc 3185461 attgggatcg attgcaacat catatccttc cacaggaatc gacctatcca cagttaacgt 3185521 atcaattcca atcacataaa ccgcagtacc ggtgaaaaca taagcaaact catgattagg 3185581 gataaatcta atcaatcgag gcggctgatc cagcaatata gttgctgtca ctgttaatgt 3185641 gtcataatcg atgacagaaa tcacattatt gttgggatgt aagacaaaca cagcgctttt 3185701 atctggcgta atttcaatac ctgccggatt gtacggaaga gcaatcgttg tcacaacagt 3185761 atcggtgttt gtatcaatca cagaaactga ttgatcattt ggattcgctg taaacgcgta 3185821 gacgggttcc ggctccggta caagcacaat tgtccccgtc accgataaag gactgccgta 3185881 aaacggcgga acaacaacaa ggttctcaat cgtgatgtca ctgatatccg ggcaatcatc 3185941 cgattcatcg gaataataga cgacttgatc gatttctgca ttgtgaatga cggaaacagc 3186001 cccgtcccct tgtccatatt gatttcggac aggtgagaca ctgacgagta gcgtaacggt 3186061 tccctgcagg cgcactgcaa attgaacacc gacctcatca ggctcaggcc ccgtttgaat 3186121 taagcaacgg tcactgacac aagaaaggct gtctgcattc cacgtcacgt ttgcaacagc 3186181 ttcagccgga tcaacgacaa acccttcagg taattcaatc ggtgcttgaa acatggcttc 3186241 tcggcttgct tctccctcac aaaaacataa gcactcttct tgttctgctc ctgctttttc 3186301 tttaaaggaa agcttgtttt ttctcattcc ttcacttcct tttcagacat acactgctca 3186361 cgcagatata acagaatatg gaagggtaac gtgtttgctt gtacaaattg ctgagggtaa 3186421 acgcttcttt ttgaaaatat atctccaaac atgcggtgta acgaaagaaa aaattgcggt 3186481 ttttttgcgc ttctcacaag aatgttgatg ataaaatatg acatatatag aattatgaag 3186541 ggagggattt gcaaacgtga caggtgtcat atcttcttct tccatcggag aaaagattaa 3186601 cgaatggtat atgtacatac gccgattcag catacccgat gcagaatatt tgcgacgaga 3186661 aatcaagcaa gagctggatc aaatggaaga agatcaagac cttcatttgt actattcact 3186721 gatggagttt cggcacaacc taatgcttga gtaccttgaa ccgttagaaa aaatgaggat 3186781 tgaggaacag ccgagactgt ctgatctgct gcttgagatt gataaaaaac aggctcgttt 3186841 aactggtctg cttgagtact attttaactt cttcagaggc atgtacgagc tggaccagcg 3186901 ggaatatctg tcggctatta aatttttcaa aaaggccgaa agcaagctga tattcgttaa 3186961 ggatcggata gagaaagctg agtttttctt taagatgtct gaatcttatt actatatgaa 3187021 acaaacgtat ttttcaatgg actatgcacg gcaagcatat gaaatataca aagaacatga 3187081 agcttataat ataagattgc tgcagtgtca ttctttattt gccaccaatt ttttagattt 3187141 aaaacagtat gaggatgcca tctcacattt tcaaaaagct tattctatgg cagaagctga 3187201 aaagcagccc caattaatgg ggagaacttt gtacaatatc gggctttgta aaaacagcca 3187261 aagccaatat gaggatgcca taccttattt caaaagagca atagctgttt ttgaagaatc 3187321 aaatattctt ccttccttac ctcaagcgta ttttttaatt acacagatcc attataaatt 3187381 aggaaaaata gataaagctc atgaatatca tagtaaggga atggcttatt cacaaaaggc 3187441 cggagatgta atatatttat cagagtttga atttttgaaa tctttatact tatcaggccc 3187501 ggatgaagaa gcaattcaag gattttttga ttttctcgaa agtaaaatgt tgtatgctga 3187561 tcttgaagat ttcgctattg atgtggcaaa atattatcat gaacgtaaaa attttcaaaa 3187621 agcttctgct tattttttga aggtggaaca agtaaggcaa cttattcaag gaggagtgag 3187681 tttgtatgaa attgaagtct aaactattac tctcttgtct ggctctaagc actgtgttcg 3187741 tggcaacaac tattgcaaat gcacctacac accaaattga agttgcacaa cgaggaatga 3187801 tttaaccgcc gtccatcggc ggttttttcg tcccctcttt accaaagtct cccaatccat 3187861 gctatgatct tttcaataat cttgaagaga gtggaaatgc agcatgtctc taaaaagtgt 3187921 gagaacccac tttactcaat ggaatcgaga aaatgatgtg acggagttcg aaacgtcgag 3187981 tgcgacagtt gaacaggcag ctgagacaat cggcgtaagc ctgtctagaa tcgccaagtc 3188041 cctgtccttc agaggggaag gagatcaggt gattctgatt gtggcagccg gcgatgccaa 3188101 gatcgacaac aaaaagtcca ggcaaacatt tggctttaaa gcaagaatgc tctctcctaa 3188161 tgaggtgctg gagcagacag gccatgaaat tggaggagtt tgcccatttg gattggctca 3188221 tgatcctgag gtttatcttg atgtatcgct gaaacggttt cagactgttt tccccgcatg 3188281 cggcagcaga aactccgcta ttgaattaac accgaaagaa ttatccgaat tttctttctc 3188341 aaaagtgtgg attgatgttt gtaaagactg ggaataaaaa aacatccaga catcgtctgg 3188401 atgtttactt atttcacaaa cccaagcagc atttcacgga tgattttgct ggctgtgttt 3188461 gccgtttgct ctgagtggtc gtataccggc gcgacttcca ctaaatcagc gccctttacg 3188521 tttacctctg aacgcgcaat ttcatggacc gatgcaagca gttctttaga cgtgatgccg 3188581 ccggcgtcaa ccgttcctgt acccggtgcg tgtgcagggt ctaatacgtc aatgtcaatt 3188641 gtgacataaa ccggacggcc cgccagcttc ggaagcacct ctttcagcgg ttcaagcact 3188701 tcaaattttg agatgtgcat gccgttttcc ttcgcccatt caaactcttc tttcatgccg 3188761 gaacggattc cgaatgaata cacattgtgc ggtccgatca attctgccgc cttacggatc 3188821 ggcgtggagt gagaaagcgg ttctccctca taatcaacac gaagatctgt atgtgcgtca 3188881 aaatggataa tcgcaaggtc tgggtatttc ttgtacatcg ctttaatgac aggccatgac 3188941 acgaggtgct ccccgcccat acccattggg aacttccctt tttctaaaat gctgtccacg 3189001 tactcttcaa tcatatccag gcttcgctgc ggatttccga acggcagcgg aatgtcgcca 3189061 gcgtcaaaga agttcaagtc agccagatcg cggtctaaat atgggctgta ttcctcaagg 3189121 ccgattgaca cctcacggat tctgcttgga ccaaagcgtg agcccgggcg atagctgact 3189181 gtccagtcca tcggcatgcc gtaaagaatg gcgtccgcct cttcccactc gggacggctc 3189241 gcgataaata cttttcctga ataagcttca tcaaatctca tctataatac cctcgctttc 3189301 ctgtaaaaaa gcgcaagatt cgctcctgcg ccataccttc attatttaat caggtcactc 3189361 acaaatttcg gcagaacaaa cgccgcttta tgaatatctt ttgtgtaata tttcgtctca 3189421 atatcgaaga aacggctgtc ttccactgca agcggatcat attttttcga gccaattgta 3189481 aatgtccaca aaccgcttgg atatgtcgga atgttcgccg tatacagctt cgtaatcggg 3189541 aagatttcct tcacgtcgcg ctgtacattt gtgattaatt ccggtgtaaa ccatgggttg 3189601 tccgtctgcg caacgaaaat accgtcttct ttcagcgctt ttgcgattcc tgcgtagaat 3189661 ccttttgtaa acaggtttac agccggtccg actggttcag tcgaatctac catgatgacg 3189721 tcatattgat tttcagattt tgcaatgtgc ataaatccgt catctacctg cacgtcaacg 3189781 cgcggatcat ccagtttgcc tgcgatagaa ggaaggaact ttttagagta ttcgataacc 3189841 ttgccgtcaa tatctacaag tgtcgctttt ttcacgcttg ggtgcttcag gatttctctg 3189901 ataacgccgc cgtcaccgcc gccgactacg agaacgtgct ccggatttgg gtgcgtgaat 3189961 aatgggacat gcgccaccat ttcgtgataa acgaattcgt ctttttcaga tgtcatcacc 3190021 atgccgtcca aaaaaagcat gttgccgaac tcttctgttt ccaccatttc taaatgctga 3190081 aactccgttt gttctgtatg taacgtcttg ttaaccttca tcgtaatgcc aaagtttttc 3190141 gtctgcttct ctgtgtacca aagttcgctc aattgtcatc tccctttcga ggctgtattc 3190201 atttattgta agcgtcttat cagcttttat tctcggttga aatctcattt tcacctaagg 3190261 aaaaagtata gaggatggcg gggaaaaagt aaagatgcgt cctgttctgc gatgtttaaa 3190321 aacgatcttt ttttctcata atagtagaaa cataaaaaaa gggggaaccc gttgtggatg 3190381 caatgacaaa taaacggctg agactgacgc tgaaaaccgt tcgcgccttt atctttttag 3190441 gggcttttgc ggccttggcg gcagctgctg tgtttatgac tgtcattttg atagccaaat 3190501 accagggcgc tccctcggtg caagtgccgc aatccacgat tttgtacgcg agtgacggct 3190561 caaagctcgg ggaaacgaac tacggcgaaa agcgctattg ggtcccctta aaggacatga 3190621 atccgacgat cgtaaaagcg acagtggcga ttgaagacca gaatttctac gatcatcacg 3190681 gctttgatta taaacgcatg gccggcgcgg cgcttgctga cctgaaagca tttgccaagg 3190741 ttcagggtgc aagcaccatc acccagcaat atgcgagaaa cttatacctt gaacacgaca 3190801 aaacgtggaa acggaaatgg aatgaggcgt tctacacgat ccgtctggaa caaaactatt 3190861 ctaaggacga gatattagaa ggctatttaa atacgattta ctacggccac ggcgcctacg 3190921 gcattgaagc agcttcccgc ctgtatttcg gcaagcatgc caaaaacctg acggatgcgg 3190981 aggcggcgct tttggcagga atcccgaaag gcccttccgg ctattcaccg tatgtcaatg 3191041 agacgaaggc caaggaacgc cagaaaacga ttgtgcggat gatggaaaag cagcagatga 3191101 tcagccaaaa gaaagcggat gaattgatca aggaacctct ttcctatcag cctttgaata 3191161 aacaagtttc caagagaaag gctccttatt tctacgacaa tgcgatgaga gagctggaaa 3191221 aaaagctcgg catgacacgg gagcaaattg aaacgagcgg gttaaacgtc tatacaacgg 3191281 tagataaacg gatgcagcgc atcgccgagg agaccattac cgaaacggtt aacgcgggct 3191341 ctgacattca agtcgggttt tcagccattg atccccgcac cggaaacgtt ctcgcccttg 3191401 tcggcggcag ggattatcaa aaaagcccgt ttgaccggac gacacaggcg aagcgccagc 3191461 ctgcttcgac gatcaagccg ttgctgtact ataaagcgat tcagagcgga tttacgccag 3191521 tcactttgat gaaaagcgaa gaaaccgagt ttcaaattga tgcaaaggga gaaacctatt 3191581 ctccaagcaa ctataacgga tactatgcca acaagccgat tacgcttctg caggcgctgg 3191641 cgctttccga caatatttac gctgtgaaaa cgcatctttt tctcggcacg aacaaacttg 3191701 taaagacggc aaaggaattc ggcattaccg cccatcttca agcactgccg tccctggcac 3191761 tcggcaccga acccgtacgt ccgattgaga tggtcaacgc ctatgccatg ctcgcaaatg 3191821 gcggaaagaa aatcgaaccg acttttattt caagagtaac ggacgcagcc ggccacgtgc 3191881 tgtacgaaaa cccgaatcag cataaacagg tgcttgatga aaaagccgct tttgtcacag 3191941 cgagtatgat gacaggcatg tttgatatcg atttaaatgg atatacgtcg gttacggggc 3192001 gaacgatagc caaccgcctg acaagaacgt atgccggaaa atcaggaacc accagcgcag 3192061 acagctggat gatcggcttc aatccgaagc tggccgccgg tgtttggacc ggctatgaca 3192121 aaaacagcac catcgactcg gtcgaagaaa aaagctatgc taaaaccatt tgggcggact 3192181 tcatggagga cgcgctcaaa ggcgaaccgg aaaccgcgtt caagccgcca aaaggcgtaa 3192241 ccggtgtgta cattgatccg gaaacaggct actcatcagg tcccggctgc gccgctaagc 3192301 attacacata ttttgtgaaa gggacagaac ccgcaaacgt gtgctacggg gcagaacccg 3192361 caaaacaaac aaaagaccgg cttccatcca aagaaaagcc cgcttccgag aaaaagtggt 3192421 gggacaaatg gctggggcga catcattgaa aataacccgg ctcctcggag gccgggttat 3192481 tcgtatggtt ccttcataat cgatggaaga atgttagaca atcgagctga acaatcagtt 3192541 ttgggataaa gtggtgaatt tctcatttct tcggcgctgg ctttcatctc ccagtcgccg 3192601 actcatatcc ccctaaaaat gaaaaacccc gagtcttgtt tcggctcggg attttccatg 3192661 tcctatttct gtatcaccag tttactcaat gtttacgaaa aatatctcaa atactttaaa 3192721 agttcacaaa aaattcataa attaattgtt ttctggaagc aggctcgttt ttaactcatc 3192781 tgaggaacgg tcccataggc cctgatcatg ctttttcaga aattcgccta gtacacgctt 3192841 cgagctgtcg tccattttat caacgatgat tttccgtttc atggatttat ccatcagatt 3192901 cacatgctca ggcagtgact tgtagcctct tctgatgctt ctgtcgaccg tcatttcaca 3192961 ggctgtcaca ccagcgtaat aaggcccctc ttcttttctg tcaatcgtta cccacacaag 3193021 ccagtatggt tttccgttcg gcacttcttc tttattcggg agaaatttaa ttcctttttc 3193081 aacggtgctg cgggcatgca tagcgccgat gtctacgaac gcttcttttt cctctacatc 3193141 aacgaatacg ggagaaatgt tatcaaggct gagtgcccct acgccaaaac cgccgtgtcc 3193201 gtctgtcgga tcacttttga taatattaaa cccgattgat tttttctttt tttcttccat 3193261 gaagttctac ctcctacaaa agcggttgaa atatcgctga aaacagcttt aaaatcgaat 3193321 ctcttcctgc attgagcatc ggccacagca cgtaagatcc tagcggtgtc acaaacagca 3193381 ccaaaaatac gataaagccg tagctctccg cctgcgtcat tttggcacgc acgcccggcg 3193441 gaacgagatc ttctataatt cgatagccat cgagcggagg aagcggcagc agattaaata 3193501 aaaacaagac aagattcagc tgtatccaaa tagaaaaaaa ctgatccagc cccgtgctga 3193561 acgccgcaag catttccatt ccgtacgcat gcatcaacac taacaaaaag aaaccaataa 3193621 acgcaagaat caggttactg acgggcccgg ctatagatac gagcacacca gcaagccggg 3193681 gtttcttaaa gaaacggcga ttcacgggaa tggggcgcgc ccacccgaat ccggccacca 3193741 gaatcaaaat ggttccgaac ggatcaaggt gtttaatggg attcagcgtc agtcttcctt 3193801 gttttttcgc cgtatcgtca ccgaatttgt atgcgacata agcgtgggca agctcgtgca 3193861 tcgtaaacga cacaattagc gtgatgacga ggtatggcat taaagataac ggataatata 3193921 aaaaacggtc caagtgagat atccctcttt ctcaaaatgc aagaatttac tttattcagt 3193981 atactataag aagcctcttt ttctaaagag aggaaacgag ataaaggagg attcagcacc 3194041 catgccatac gtaactgtca aaatgctcga aggccgtaca gacgagcaaa aacgcaatct 3194101 tgtcgagaaa gtaacagaag ccgtaaagga aacaaccggt gcttctgaag aaaaaattgt 3194161 tgtctttata gaagaaatga gaaaagacca ttatgccgtc gcaggcaaac gcctgagcga 3194221 tatggaataa tctctataaa gccggcgctt cgcgcaccgg cttttattat ccctattgag 3194281 ccagcttcgc aataatcgcc aagaacgtct ttttctcttc ggctgttaaa cgttcaaaca 3194341 tgccatcaat cagctgctgg cggttttcga tcatttgttc agccgctccc cggcccgatt 3194401 cagaaagagt aatccataca gtgcggcggt cattgttatt tctggatctc tcaataaacc 3194461 cttcctgctc taaatgattc agagctgtgg tcgtggcaga gggagacagt gtgacctcct 3194521 tcaaaatatc ctttatggtg cagctcccat gtctgtatat gatccgcaga ataaaccctc 3194581 ttacattatt cacgtgtttc ggaacggtgg cttcatctaa ttgcttcgtg cttttcaaat 3194641 actttgtaag tgcgtgatcc agcaaatttg cttccagttt gtcatggtcc atgtcaattt 3194701 ccccatttcg agatgcattc ataacatacg aacgatatga tttacttatt attttactga 3194761 ttccgaatag ggaaagtcaa aaaagcaaaa tgtgaattca cagcttttat cctacatgcc 3194821 tcgattttcc acctgtttca caagtttatc tttaaaagtt tggaaaggaa cgtgttcatt 3194881 ctgctgatgt ccgaatcggc ggacgtttac cgcattctcc tgctcctcat gatctccaag 3194941 caccagcacg tacggaattt tttgcacctg cgattctctg attttatagc cgagcttctc 3195001 attgcgctca tcaatgccgg ctcttatccc cgcctgcttc agctccgcct gcacttttct 3195061 gcaatagtct aagtgaacgt gcgaaaccgg tatgatttga acctggatcg gtgcgagcca 3195121 gactggaaaa gccccaccgt aatgctcgat caaaatgccg aagaaacggt cgattgagcc 3195181 gaaaaccgct ctgtggatga caacgggacg aaccttctca ttgagttcgt tgatatatgt 3195241 taaatcaaat ttttccggca tttgaaaatc aagctgaatt gtcgcgcatt ggtggctccg 3195301 tttcagggca tcttttatat ggaaatcaat tttcggcccg taaaacgccc catcgccttc 3195361 attgatctca taagagaggc caagctcctc aaggacgcgt gctaaggcac gttccgacgc 3195421 ttcccaaagg ctgtcatcgc ctaatgaatc ctccgggcga gtcgaaagct caacagaata 3195481 ctcgaaacca aatgtccgat atacctcatc aatcagccga atcgcttctt tgatctcact 3195541 ctcaatctga tcctcccgaa cgaaaatatg ggcgtcatcc tgacagaacg tccgaacgcg 3195601 aagcattccg tttaaagcgc cgctgtattc atggcggtgc acctgtccga attccgccat 3195661 gcgaatcggc agatcccgat aagaatacag gctgttttta aagatgagca tgtggccggg 3195721 gcaattcatc ggcttcattg cgaatcttgt atcatccact tctgaaaagt acatattgtc 3195781 gcgataatgg tcccaatggc ctgactgctc ccataaccgc tgattcatca taaacggcgt 3195841 acgcacctca tcgtagccgg catttgtttg cagctcacgc gagaagcgct ccagctcatt 3195901 gcggacaatc tgccctttcg gcaaataaaa cggcatcccc ggcgcttctt cagaaaacat 3195961 aaacagccct aactgtttgc cgagcttgcg atggtctcgt tttgccgctt cttctagcat 3196021 atgcaggtgc gcatccaaat cttttttctt ttgaaacgca accccgtaca cccgctgcag 3196081 gacttcattt ttgctgtctc cgcgccaata agcgcctgat actcttgtca gtttgaacgc 3196141 cttgatcatc cctgtagaag gaagatgcgg ccctcggcac aggtcaacga attccccttg 3196201 ctggtacagt gtgatatcct ccccgcgcgg aatatccttt aaaatctcaa gcttgagccg 3196261 ctcgtctttt tgtgcaaaca gctcttcagc ttcttcgtaa gaaacctcta tacgtttgat 3196321 ttcaaggttc tcatttatta tgtttttcat ttctttttcg atggcctcta agtctcctga 3196381 tgccaagctt ttccccagct tcatgtcata gtagaagccg tctaaaatca caggccctac 3196441 ccccaatgac acttcgccgt acagccgttt tactgcttgg gccagcacgt gcgctgttgt 3196501 gtggcgaagc acctgcaagc cttcttgtga atcgagtgtg acaatcgaaa gctcagcatc 3196561 ctcctccagc ttgaaactga gatcaacaag cttgccgttg acctgacctg cggccgcctt 3196621 cttttgcaga ctggaactga tcgaaccagc cgcttctttg attgtgatgc ctttcggata 3196681 ttcctggatc tgtccgtccg gaagctgaat gtgtacatgt ttgctcattt tagaacactc 3196741 cttattcatt gttgtatata aaaaaacaca cccgtcccgc agatagggac gagtgtgtga 3196801 ttaacccgtg gttccaccca agttcccgac aaatactatg ttgtcggctc ggtgctgtaa 3196861 cgcagcatag acggcattgg ttacttcagt tccccaatgc tgctccaagg cggtaaatga 3196921 tattcctaag ctgggaagct ctcacctttc cttccctctc tgaaaaccgt aactatcatt 3196981 catgtccttt tcatcgcatg tattcaattc ataaaaaaac acacccgtcc cacagatagg 3197041 gacgagtgtg tgattaaccc gtggttccac ccaagttccc gacaaatact atgttgtcgg 3197101 ctcggtgctg taacgcagca tagacggcat tggttacttc agttccccaa tgctgctcca 3197161 aggcggtaaa tgatattcct aagctgggaa gctctcacct ttccttccct ctctgaaaac 3197221 cgtaactatc attcatgtcc ttttcttcgc atgtattcaa ttcaaataaa aaaacacacc 3197281 catccctcta aaagggacga atgtgttgat catccgtggt tccacccaaa ttcccgatca 3197341 attacacatg atgatcggct taaagatgct gtaacgcagc atgacggtat cagatacttg 3197401 ttttccctga tacggctcaa aggcggtaag ctgctttccc tgcgttagga agatctcagc 3197461 tgtccttccc tctctggaaa ccgtaaaaag catctcgtgt ccttatcagt gcctgttgtt 3197521 tcaataattt tttatatctt actatatatt cccacaaagc gcaatcagtg atttacattt 3197581 tttctgacgc ggcagtcccg ttatgggcag ccagaaacag ccatacaagc aatgcagcga 3197641 ggctgtatgc cgctcccatc atcaaaaacg caaacccggc accagcatac caagtggcgg 3197701 acagatgaat gatcaccccg gttatcgcta cgccgaccaa ggctccgatt tgccggtttg 3197761 catttaacgc cgcaccggcg atattcgtat gtctttgccc ggcagcctgc atgatcacag 3197821 ttgtcatggc aggaactgta ataccggtac agaggttcat aacagacatc aacaccgcca 3197881 gctgccaata aggaaaatcc ggagaaatca gcacaaacaa cagcaatgca atgatacagc 3197941 tgaccgccat tgatacaaac ataagctgac cggcttcaaa ccgattcgcc agacgggcaa 3198001 acagcagatt gccgatcacg aagaccgcca tcatcggcag cagctccact ccagccataa 3198061 aggaacttgc ccctcctgct tcctgcaaaa aaaggctgag cataaacatg ccgccaaaaa 3198121 gggcgaaatt cagcaaaaac ccgataaatt gggcagctga gaagcggccg tttttgtata 3198181 aggacgccgg caggatgggt gtttttgcag aaatttcccg cagcaaaaac agcacaaatg 3198241 ccaaaaccgc tgcagtaaat gctacaagaa tcactggcga gcgccagccc gctgaaggcc 3198301 cctgtatcaa agcataggaa agaaacccga gagccatcat gccaagcaga tgcccgatga 3198361 tgttcacgcg gctgcttttc ccaggaacgc ggctgaggat tcggtaagct gaaatgagcg 3198421 cagcagcccc tattggcaca ttgatcagaa aaatactctg ccagcccgcc aactgtacca 3198481 gcacgccccc gataaaaggc ccaagggctg aagcggcgga aacaagcgcg gcccacagtc 3198541 caaacattct cgcccgcgcc cgctcatcaa ggtaagaggc agccaaaagg ctgagtgagc 3198601 ttggcataaa caaagctgcc ccaattccct gtatgagacg tccggcaatc agcatctgcc 3198661 catttataga tgcagcgcat agacaggagg ccataacaaa aacggctaga cccaagatat 3198721 agatcgtctt cgagccgaaa cggtcagcca aggctccgcc cgccagcaga agcgacgcaa 3198781 aagtaagaat gtacccgtcc acaacccacg ttacacctga aagtgacatt gaaagagtgt 3198841 ttttcatatc agccatcgcc acattcacaa cggtcacatc aagagttgcc atgaggaaac 3198901 caagtgcgag cacgatcagc acggatatgc ctgttgatga tgttgattct tgtatagacc 3198961 cgctattttt cattacaatt gccctttcac ttgcttgatt acccaatcat ctattttttc 3199021 aagatcatac aattccccga ctctgtccat aacatgctgc aaggattctt ctctcataag 3199081 attggaccat ttatcctcga tttccgccat gactgtctcc agcacacagt gactttcacc 3199141 ctcaaataca gattgcagca agcctttccc ctgatacatc gaacctctgc cttcgaccgc 3199201 ttgataaaca tcataaagcg taatgtcagc caaaggcttc gtcagggtaa aaccgccctt 3199261 cgtccctggt aaggattctg ccaaaccggc ttgaaccaat gttctcatca gcttcttcaa 3199321 gtaagacgga gacacgcgca atcgctggct tatagcctct gacgtcaaag aagcctgtac 3199381 cggcagccgt gacagtaaca gcagcacaga aaccgcctgc tccattcctg atttcatttt 3199441 catcctattc actcctgatt cattatggat aactattatc cataatgaat ctcttagcag 3199501 cttttgtcaa taaaaaaagc aaaagaaacg gatcatttct tttgcttggt atggttaaca 3199561 aatctgcttc agttcctcta tgtattgaag cgcttcgtca tattcttcat ttgtatattt 3199621 ttgcttgctt ttgatggtaa agactttttc tttcttttcc tcatcctcaa gcccgtcaaa 3199681 gtaaaggatc gtggaaacca gctctaaaaa ccgtgatgaa cggctgttta cactgtcgat 3199741 atagcctttc atatccggca tgtccagatc agcatggtct aaaaatgcgg agcctgtctc 3199801 agtcagcgaa taccggtatt gaaagtagcc gccctttttt tccttcacct catgcagaaa 3199861 tccaaggttg cacagctctt caatctggag cgtcagttcc tctgaatatg gtccgtaaaa 3199921 gtgaaaatca tatttctcat agaaaggaaa ctgcattttc ttggcgatat aaatcatttt 3199981 ctgcagcttc tttcgcccga tgatttctcc agaatccgag aacaccttca tcagttttgc 3200041 atgttctttc aacaaattcc cgacatctcc tttttccttc tttccaattt ctatgtcagt 3200101 cccagcagct gccggatttt cattttcgct tccggatgtt tagtgccgtc acaaatcaag 3200161 tcctttggat agtacagctt gtggtccgtc cgccgtttac ctgagatgga ttccacaata 3200221 gccgactgtc tggacagctc tttaatttgg ccgttttgcg tcaagagatg gatcggcaga 3200281 cgctcctctt cctctcctgg tcggtaaaaa tcgtatggca gatctgatga agaatcaacg 3200341 accaaataat agctcggatc gatccccgcc tctttgaaca atgaagtcag ctcaaaataa 3200401 gccgacattt cttcattcgg attgaattca acgtattgga aaagctggcg gttaatgaat 3200461 ctgcggcaca agtcggataa aatcgcgtct tcttcatcct cccaggcctg gaagtaatac 3200521 aaaataatag attcatccag ctttacataa tcctccagtg tcaattttcc ttcaaaaata 3200581 gaatagaaat gaaccggagc gtgagtgaag acatagcctt catcgtgcag ctgcttcgcc 3200641 ctgtgaagaa tcttcgttaa aatgacctct gcacttctag tcacaggatg gaagtagacc 3200701 tgccagtaca tttggtaacg gctcatgata tagtcttcga cagcgtgcat tccgctttct 3200761 ttaatgacga tctgatcctc gcgcggccgc atcacccgaa gaatccgctc catatcaaaa 3200821 tggccgtagc tgacgcccgt ataatatgcg tcgcgctgga ggtaatccat gcggtctgcg 3200881 tcaatctgac tcgaaatcag gctgaccact tgcttgtttt tatatgtttt ggcaatgact 3200941 tcagcaacat cctgagggaa acccgggctc acctttctga gcacctgatt aacctccgtg 3201001 tctcccaaaa tgatacctct tgtaaaatcc tcgtggtcaa ggtgaaagac cttttcaaat 3201061 gaatgcgaga acggcccgtg cccgaggtca tgaagcagcg ccgcggccaa acagagttcg 3201121 cgctcactgt catcccattc agggcggcct ttaaagacgt catcaaccat tcttctgaca 3201181 atttcataga caccgagaga atggttgaac cggctgtgct cagccccatg gaacgtcaaa 3201241 taggtcgttc cgagctgctt aattctgcgg agacgctgaa attcacgggt tccgatcaaa 3201301 tcccatatca gcttgtcccg aacatgaaca tagcggtgca ccggatcttt aaacactttt 3201361 tcttctgata attttccatt tggatacgcc atcgtcattc cctctttttt ttagccgtgt 3201421 ttctattata tcgactctat tctttgaaaa catccttgaa tttgcccggc gatttgttcc 3201481 atcttcatga aaaacacatc ttgtgaagca aaaaagcctg acctgagggc cgaggctaag 3201541 aaaaaatatg tttttacttt tttattttct tttttacttt gtcaatcagc tcatcctctg 3201601 tcggagctga cagcgggcga ttgttcacaa aagcaaatga ttttttccgt ccgggcccgc 3201661 aataagattg gcatcctacc tcaacctttg cgtccgggtc cacttctttc aaacgcggca 3201721 gcaatgtttt gatattagtg gcttggcaat catcacacac tcgaaattca ttagccatga 3201781 cgtacgcttc ccttcatttc tatgttcatc tatgtgaata acctaaaatc acgtttcaaa 3201841 aaaaatcaca tcacacttca ttttacaagg attcgactgt tcctgcaagc cgctccatcc 3201901 ttcgtatctc ctattctttc agccaatttg tataaatatt ttccaacctg gacattctaa 3201961 taccatgaaa agaaaaatgg gagttgagat aaatgacaaa acagcgacaa gacgcttggt 3202021 cagaggaaaa cgatctgctt ttagccgaaa cagtgcttcg gcatgtgagg gagggcagca 3202081 ctcagctgaa cgcctttgaa gaagtcggcg ataaattaaa ccggacatcc gcagcctgcg 3202141 gattcagatg gaacgcagtg gtccgccatc aatatgaaaa agcgcttcag cttgcgaaga 3202201 aacaacgaaa acagcggatg agagcgctcg gaaacgggca gcccgcgaaa aaaagattat 3202261 tatatcagcc tcctgccgtt gatcctgaaa tcattcaaga aaccgctgca gaagagccgg 3202321 ttaaaacgga aacaccatct gtcgaaaatg agcaaccttt aatgtctggc gaacacatgc 3202381 cttttgttga tgaaagcttt aaggaagagt tagctagtct atcacactta ttgtctcctc 3202441 aaacgcctgc agctgcgcct gagatgacga tgaatgatgt gatccgcttc ctgcagaatt 3202501 acgaaggcaa tcacgagcaa tcatcagcat taaaaatgga aaacgagcgt ttaaagaaag 3202561 aaaatcagga attgcaaaac aaaacagagc agctagaggc agaagttcaa aagcttgaaa 3202621 aagaccaaaa aacgatccaa gaagattatg aaaccttggt gaaaattatg aacagagcca 3202681 gaaagctagt tttatttgaa gaagatgaac atgcctctcc gtccttcaaa atggaccgga 3202741 acggcaattt agaaaaatta gcggaatgac atagaaaaat cccaaaacgg gcagctgttt 3202801 tgggattttc gccatgtgca aaatcccctt ttctattgag aaaagagaat ttcctcattt 3202861 tgcagccgga tcagctattc ttgtaaaatg aggccaagct tatgtgaatc tattaagaca 3202921 tgtgagctgc ctcggccgtt ttttgtttcc gaggcgcagc agaaatgacc aaaagcccca 3202981 gcatcataag cgcaatgccc agccacgagg aaggcgaaag catttcccct atgaaaaaca 3203041 cgccaagcaa tgaagccgtc agcggttcag ctaaagacag cgtgaccgcc gccgaggccg 3203101 gaaccccggt aagccctttc gcaaacaaaa agtatgcggc acatgttgca attaacccga 3203161 tgtaaaggct tgttcccagt cctctagggg tcaatatcca cgagatatct aactgccata 3203221 atagcggcgt cagcaagatg gcgctgatca tgaatacaac ggcggaggtc gctcgcggag 3203281 gctgggtttt catcatcgct ttactgatga gcgtatagcc tgcaaaagaa gcacccgctc 3203341 caagcgccat aagaacacca gccacatcaa tccgaacatt ggaactgtcg gaaaacagaa 3203401 gccagcaacc cgctaaagcc agcacagtcg caatccacca ggagtttcgc gggcgtttct 3203461 tcaatacagc ccattcgagg gtcccggcaa tgataggcgc actgccgatg gcaatcacag 3203521 ttcccactgc aattcccgtt tctttaaccg ctgtgaaaaa cagcggctgg taacacgcca 3203581 tacaaacagc ggctaaaaat acgagcggcc atgcccaatt tttcacgtga agctcccggc 3203641 tgatccaaac cgcaagcagc atggcgcttc ctcctattaa taacctgaac gctccaaatg 3203701 ccagcggtgt ggcgctttct ggagccaatg cctgaacggt tcccgtggtc ccccagaaaa 3203761 aagccgcaat caatacaaaa aggctgtaaa tattcccctt catctgcctc tcccctttaa 3203821 tatggatgct gatgtcattt tatcgttttt ctttttgtcg tggttatctg tatgtaagaa 3203881 ggacttatct gaaaataaga ttattgaggt aaaatgccgc ttgagataaa aaatgcatgc 3203941 cggcatatac agccggcatg cgaagaacgt tcacccaaat acctttgcat tccgctcagc 3204001 catccggacg aggtttttct caaattccat ttcctcatca atggacagtc cagctgaata 3204061 aagatgggtg cttaacgctt ttaattccgt caataaagcg aacattaagt cttgtacgga 3204121 gatgtctttt tgaagaagct cacttaagga cgccatcgtt tccggacgta tttccggata 3204181 gacgcctttt ttatcgtttt gtttgtcttt cagcgccgct tgatagaatc gtctgatcaa 3204241 gtcggccctt tcactgccgc ttttatctgc acagagataa atttgaacag cgactccgcc 3204301 gcgaacgcgt ctctgagaga tgccggcgaa ctttttgcca tttatactga ggtcatagct 3204361 gccgggacaa taagaccctt caatttcata ggcttcgatc tttgcgttgt acggtctcag 3204421 cattcgtctc atcagctcga ccatcgcttc atatcctttg tctatatcga tgcctttctt 3204481 ttcgtcctcg aatatgagag agatatttaa aacaccgtca tccaatacga cggcaagacc 3204541 gccggaattg cgtacgatca cacggtatcc ttcgctctcc agcaaggaga taccatcctg 3204601 caaaaacggg aggcgtgtat cctgtattcc aaggacaatt gtatcgtggt gcacccatga 3204661 gcgcgctgtc gccggcgaca cgccttttcc gacggacatg catagcgtat catccattgc 3204721 gaaggattgc ttcgcatcaa ataaagggcc gagactggat tggtcaatga ctctccattt 3204781 cggctgcatc agtaaatcaa tcggttggtt tgccatctat gtaaaaccct ttcatgttag 3204841 gcttattgaa cgaaaactat tatatcattt cagcagctgt gattgataat tgcttttcag 3204901 catcgtaata aaaatttctt tattttttgt attctccatg agaggagaat gaatgtaaga 3204961 cagcttgcgc tttaacgaga aattattaat atgcagaatt gaaatttcgc ggtggatcaa 3205021 atccttacgc agcacgcttc tggatagaac cgaaagtccc atgccgttaa tcaccgcttc 3205081 ctttacacct tgattgctgc tgatggtaaa cattgatttc ggccgaagtc catttgaact 3205141 gagtacatga tcgagatatt ctctcgtccc ggagcctttc tctcttgtca cccacgcttc 3205201 gttctgcaaa tcgctgatcg aaatctcttt ccgcccggcg agcggatgct gatttggagc 3205261 ggcaatgcac atttcatcct ccatgaacgg ttcaatttcc agctcattct cgtttgtatg 3205321 tccttcaatc agcccgatat cagcctgaag catccgcaca cgctcgctga cctcctctgt 3205381 attgccaatc atgacatcta gattcagctc tggatacagc ttttgcagct gggccaatag 3205441 cggcggaaga atatactcac cgattgtaaa gcttgcagct attttcaatt cacccttcac 3205501 atagtgatga tgcgcataga tttcagcctt ggcttgttcg tagagaaaca ccatttgctt 3205561 tgctctttga tataaaatgt ctcctgtcgg cgttgtcgta aagtgttttg gcgacctgtt 3205621 cagaagagcc gtttgaaatt ctttctcaag atttttgata tgcagactga cgctgggctg 3205681 ggagatcatc agcttttccg ccgcttttgt gaagtttttt tcttctacca ccgctataaa 3205741 cgttttcagc acgtcgtaat acaaaaaccc cacccctgtc attaatgaaa tatatggtta 3205801 tgattagttt tctttattgt actcatatca tccgtcttgg taaagaaggg ctatacagaa 3205861 gcgcaaaaaa ggcagccctc ggtcgagagc tgccattgtc ttcaatttta ttacagtgct 3205921 tgcgccgctg taattaatgc gagattgtaa acatcttcag cgttacatcc tcttgaaagg 3205981 tcgtttacag gcatatttaa accttgcagg attggtccta ccgcttcaaa gttgcccaaa 3206041 cgctgagcga ttttatagcc gatgtttcct gcttcaagac ttgggaatac gaatacgtta 3206101 gcgtcccctt tgatctcgga atccggcgct tttttctcag ctacagatgg aacaaatgca 3206161 gcatcaaatt ggaattcgcc gtcaagtgtc agttcaggcg ctttttcttt cgcgattttc 3206221 actgcatccg ctactttttc tgtttcatca gattttgctg agccttttgt agagaagctg 3206281 agcattgcca cgcgaggctc aatgtcgaac atttttgccg tattggcact ttcgatcgca 3206341 atctcggcaa gatcttggct gtcaggtgca atgttgatcg cgcaatctgc gaatacgtat 3206401 tgctcttctc cgcgagccat gatgaacacg cctgaagtct ttttcacgcc ttcttttgtt 3206461 ttgatgattt gaagagccgg gcggacagtg tcagcagttg agtgagcagc tccgcttaca 3206521 agtccgtctg caagtccttt atacaccagc attgtaccga agtagttctc gtctaataat 3206581 gctttacgag cctgttcttc agtcgctttg cctttgcggc gttctacgaa tgcttgtaca 3206641 aggtcttcca tgccttcata tgtatgagga tcataaatct taacgccgcc cagcgtaagg 3206701 ttcaattctt ttgcttttgc ttggatctca ttttcattgc cgatcacaat cggattcagc 3206761 actttgtttc ctgcaagctt gctgaccgct tctaaaatac gctcgtctaa gccttcagga 3206821 aatacaattt taacgtcttt tccagctact ttttcttgca ctgttgaaaa taaatctgcc 3206881 acaataaaac ctcctcaaaa agttacaaaa acgctttctt ttactagcat actcttcttc 3206941 caatcaaatt caaacagcca actttcatta tagcgctttc ataaaaaaat cttatttttc 3207001 taactaattt aagtgactca atcttccctt ataggttctt ctattttgat ggagttatac 3207061 ggaagggatg ttcaaggttt ctccacagta gaatcggata aactatggta tagtgaaggc 3207121 aatcatgaaa agataatggg agtgaagata aatgagtgaa cagcaaatga cgaatgaagc 3207181 ggcaaaaacg cttgacggct ggtatgcgct tcatgatttc cgcacaatgg attgggcttc 3207241 ctggaagctt ctgtccagtg atgagcgcca atctatcata catgaattca ccgggttgct 3207301 tgaaaaatgg ggcgtagccc aaaaagaagg aaaaggatcg caaactcttt acagcatcgt 3207361 cggccaaaaa gctgatttta tgctgatgat ccttcgtcct acaatggaag aattaaatca 3207421 aattgagctt gaattcaaca aatcaagact tgctgagttc accattccgg catactccta 3207481 cgtatcagtg gtagagctga gcaactactt ggcaagcggt gacggcgatc cttatgaaaa 3207541 tccgcatgtg cgcgctcgcc tttaccctga actgccggaa tctaaatatg tatgcttcta 3207601 tccaatggat aaaagaagat ctggcaacga caactggtat atgctttcaa tggaagaacg 3207661 cagaaacttg atgagaagcc acggtttaat cggccgcagc tatgcgggca aagtcaaaca 3207721 gatcatcacc ggctctgtcg gctttgacga ttacgagtgg ggcgttacat tatttagcga 3207781 tgatgtcctt caattcaaga agctagtgta cgaaatgcgt tttgacgaag tcagcgctcg 3207841 ctatggcgaa tttggttcat tctttgtcgg caatcacctt tcgcttgata cacttcctca 3207901 attcttatat gtataatatc cccgagctcg tttattgaga taaggactga tcggccttct 3207961 gctcaagttt gccgtacttt ttatatgcga atacactgag cacaaatccg aggactgtga 3208021 tggcggcgca aatcaatccg acagctgcat agccgtatgc cacatatacg ggtcccatta 3208081 aagcagaacc taatgtcacg gccagattcg aggcgagact gtaaaacacc atgacttttc 3208141 ctcgatgacg ctctgagcag tcactcaaaa tggtgctgag cagcgtcacc gtcaaacttt 3208201 gcattaatcc ccaaataaat aggctggcga ttaacagaaa catagacgcc ggcgcatatg 3208261 gtaaacacgc cagcagaacg ctgatgaccc ccagcgcaat caaaagggag cgcatttttc 3208321 cgatgcggtc ggctatcttt cctgtaatca cactcatgga aaacccgatt ccataaatca 3208381 tgataaataa gcccgcagcc gtgtttcctc cggtaaaaac gtcctgaaga taggtgccta 3208441 aaaaggaata cataccgtaa aaaccaatca tattacaaaa ggttattgtg atataaacag 3208501 gtacacgagg gactttcagc gcatcccgga atgttcctgc gggctcttct atttcttcct 3208561 tgccgctgtt tttatgttgg gcatggcggc gcatttcaag gagaatcagc agaacaacta 3208621 aaacacccat cagggcgaaa atccaaaacg tccatctcca atgcaggacg ccgccgataa 3208681 atgatccgag cggcactccg aaaatcagcg ccagcgacca gcttgaaacg atcagtccca 3208741 tcaccttgcc ccggtatgta taaggaacac gatcaccgac aactgcgtaa gcggtcggaa 3208801 caaacgctcc cgcagccaat cccgaaagcg cccggcctaa aaagaagaaa aaaatatttt 3208861 gagctaaagc gcatatcacc gttcctatga taaaaatcat aagcccggcc aataagctca 3208921 gttctctgga gtatttatcg cctaatggaa ccaaaagcgg cgcaccgata aaaatcataa 3208981 cgccgtaaat actgatagat aacgcaagga cgctgacatc tgagctgaag gcttttgcta 3209041 aatccggcag cagcggtgag atcacaagct cttcagatcc ggctgcaaat acccccatcg 3209101 ttaaagccag tgccaacaat aacggaaaat gatgttttgt tttgatgtca ttgttttgat 3209161 tgctgttcat tctttctcaa acacctcttc cataatcttc ttatcataaa gttgtattat 3209221 agtttagcat tgttttttct ctatttacaa ttcgaacgaa atatttataa gttttattat 3209281 tttcatttaa atcccattat atatttctat atttcattct aaaaatacat gaggatgtaa 3209341 cacgtaaaaa aagctctccg gcctcccgga gagctttttc tattgcgcct ctgtctgctt 3209401 tttttcaatc gtttcatgat ttatacgctt tttgatgctt agatgatagt atgcataaca 3209461 gaaaataatg atcggcacac cgcagtataa gccaattctt tgatccggaa tgaaaataag 3209521 gctgatcaac acgcagccat ataaacaaaa tccgagaatc gggactagcg gataaagcgg 3209581 cgttctgaac tccagatcat tcacatttcc gccttctgcc aggaaacgcc tgcgaaagaa 3209641 aaattgcgac gcacaaatgg acatccacgc gacaactgtc accatgcccg agattgagat 3209701 acaccataaa tacactgttt ctgcagccat gacacttgtc agcagcgaac agcctgaaat 3209761 gcctagcgta atcagcaggg cattcatcgg cacgcctttt tttgtcagtc tggtgagaaa 3209821 ggagggaccc atttgatttg atgaaagtga ccacatcata cgcgacgccg catacaatcc 3209881 cgaattagca acagataaaa tggccgttaa gatgacaaag ttcatgatat ctgccgaaaa 3209941 tgggatgccg atttgatcga gtactgctac aaacgggctt tcaatcaccc ccgccgtttt 3210001 gtacggaagg atggcaacca agacgaacat agcgagcaca aagaaaaaca gcgtgcgcca 3210061 aataacattt cgaatggact ttggcagtgt tttttccggg ctttcacttt cccctgccgc 3210121 aatgccgaca agctccgttc cctggaacga gaagtttacc atgaccagcg taaacataac 3210181 ggccagcacc ccattaggga aaagccctct atcagtcata aagttagaca aaaagggtgt 3210241 ctcctgtccg cctttaaagt caatcaagcc aaacacagcg gctccgccaa tcacaataaa 3210301 taatatgatc gccgccactt tgatgcttga aaaccaaaat tccatttccg caaagcttct 3210361 gacagagagc gcattaatca aaaagatgac gatgccgaac acgaggcacc atatccagat 3210421 cggaacggag ggcagccacc tttgcatcaa aatgcctgct gacgtcagct ctaaccctac 3210481 tgtattggcc cagctgaacc aatacagcca gccaatcata aagcctgtcg actgtcccag 3210541 aaatttagtg gcgtaggcct gaaacgatcc ggccaccggc atggcaacag ccaattctcc 3210601 taaacaaagc atgacgagat acattaaaaa tccgccgatg atatacgcgg caatggcgcc 3210661 gagcggtccc gcctggctaa tggtaaagcc agagcctaga aacagcccag tgccaatcac 3210721 ccctcccaaa gcaatcataa acaaatgcct gcttttcatg ctgcgctgca attcattttt 3210781 atgattctgc atcatccttc cccctttggt tcttttgccg tgatggtcat ccggtagctt 3210841 tgcaaaagat gaacggtggt ttgctgtatg aggagaggca atacatgaaa tgtgtacggt 3210901 ttatagactc gttctgtcca tttatggccg tcttttccgt acacgcccat attaatggat 3210961 ggaatattca gcttgcgtat gtctttgaac ggaatggtcc caatcatatt ccacccaggg 3211021 aagttcctga taaaagaatc aatttcgcca tcggtttcgt gcagtgataa aaaactgccg 3211081 tctgccaagt aggggaaaaa ctttttgaag acaaatgttt cgcctgtcga ttcagcggtt 3211141 ttgtcagccg cttctttaat cacatgctgc aaaagctgat ctcttgcgct atcttctttc 3211201 aaatagttat gcggcaggta aggaggtgcg taaaatagaa tgacttttgc gccttgatcg 3211261 gggtcaagct tttgaagctc ttcgattgcc tgaaagcatc tcatgcgaag ttcaaggtgc 3211321 tcgttggctt tgaatgtctg ctcgatacac tgctcgggat ctattccccg gtttctcagc 3211381 ttttctaagt attgctccag gctatacact tgaatgcccc atgataaatg tttctttggc 3211441 aggttggctc tttttacata ttcttcgtaa taatctgata atttttgttc tgtctcccgg 3211501 catgcttcct cagtgacttc aataagcaaa tccatcattt cttttgctgt tctttcataa 3211561 ataaaacaat tgaaatacaa gctggtgctg acagccgttt gcacattata ggattccttg 3211621 ttatcacgct gatacaaaca ggatgggggc agaaccaact ccccttcaac cttttctgcc 3211681 agatggatgt tattgtggag acggcttgtg atttcagatg aaatgaaatt tgggtcaatc 3211741 cctgccagtg tatcgccaac atggacttca cgcccgtaaa tgtaaaagca aggcaacagt 3211801 tttcccgcgg ctccggtata gatatatctt gtctgatcac catcgtaaag cggggtaata 3211861 aaatccgtat taatagcagc caaatagtga agctgttttt ctttttttag ccggttcagc 3211921 tctgaaatgc tggcgagaat gcccgaatgc tggctctcct catcgggatt ggccataaac 3211981 aatacatttc ccggcaacgt ctcaaggttc tccgaaaaat gcaggagatt ggctaaatgc 3212041 acggcgatgc cgctttgcat atcgacagat cctcttccga acatccactc gcctgatttg 3212101 gcatcccgct gaacatcctg atcgaactca tagcggctga aatactcggc caatttctca 3212161 caatcaaaag cgatatcctt taaagggccg aaatcttcaa ttccaactgt atccagatgg 3212221 gcatggtaaa tgactgtatt tcggctttct ccatgtcctt taataaacgc aaaaatattt 3212281 ttgcgtttgt atgggtcatt gggaatggcc tgttcccaca catgactggg gttttcctga 3212341 aaataaggat agctcgtgat cacttctttg atgaaatctg cttttgtccc ttctccaacg 3212401 gtgccgttca cgctgctgag gctgaccaga gatgctgtca gcgcctccac tctttcagcc 3212461 ggattcatgt gactgatttt tgtatactgc ataaattgtc ctcctgatca aaaagttgaa 3212521 atcgtgcgat ccgctaaaga atcgcacgat tttatttctc tcaaatcaaa aagcttcgga 3212581 cgttgttttg gcttgcatat gaagaattaa gtaatcggga ccgcctgctt ttgagtctgt 3212641 tcctgacata ttaaaaccgc cgaacggctg atagccgaca attgctccgg tacatcctct 3212701 gttaaaatat aggtttccga catggaaatc ctcgcgcgcc cgttcaatgt gcgcacggtt 3212761 tttcgtcaga agcgcacctg ttaatccgta ttccgtgtta ttggcaatct ccagcatatg 3212821 atcgaaatca cgcgctttgc aaatcgcaac aaccgggccg aaaatttctt cctgcatcaa 3212881 gcgggcgttt tcatcaacat ctgcaaagat cgtcggctga ataaagtagc cttttgaatc 3212941 atcgccttct ccgccggcca atagcttgcc ttcagatttg ccgatttcaa tgtatttcat 3213001 cactttgttg taggatgctt catgaatcac gggacccata tacgtatcag gatcttctgg 3213061 attgccgaca gtcagcgttt tggtcagcgc cacagctttt tccaccactt catcatacac 3213121 atcctgatga atgaccgcgc gggagcccgc agaacacttc tgtcctgaat atccaaatgc 3213181 tgaatacacg atagaggatg cagcaaggtc aagatcagcg tccttgtcga caagcactgt 3213241 gtcttttccg cccatttctg caattacccg tttgagccat ttttggcccg gctgcacttt 3213301 ggcagctcgc tcataaatcc ggcagccgac tgcacgggaa cctgtaaatg agacaaaccg 3213361 tgtcttcgga tgctcaacta agaaatcacc gatctccgca ccatctcccg gaatgtaatt 3213421 cagaacgccg tttggcagac ccgcttcctc catgacctcg acaaattttg ctgccactac 3213481 cggggctgcg tcagccggtt ttaagagaat cgtatttcct gtcacaatcg ctgccaccgc 3213541 tgttcccgcc ataatcgcga gcgggaagtt aaatggagaa atgacgatgc cgacgccaag 3213601 cgcttcgtaa tgatattgat tgacctcgcc agcacggctc ttcaccggag ccccttcctt 3213661 gagctttaac atttggcgcg cgtagaactc taaaaagtct atcgcttcag ccgtgtccgc 3213721 atctgcttcc ttccacggtt ttcctgcttc cttcacaaga tagcttgaaa attcatgctt 3213781 tcttctgcgc aaaatagccg ctgccttaaa gagaatattt gcgcggtgct ccggtctttg 3213841 ttttttccag gaatcaaatg cctgcaatgc ggcttgcatc gctttttcag caagctcttg 3213901 atccgctgta gacgcgtacc caatgatctc ttctttattt gccgggttaa tagaaatgat 3213961 tttgcggtcc gtttcaattt tttctccatt tatgacaagc ggataatgct tgccgagctg 3214021 agtgtttaca aaggccaatg actccccaaa tgcagtttta ttctttgctt ccgtaaaatc 3214081 ggtaaatggt tcgtgcgcgt atgtgactgt catatgtagt ccccctcgtg ttatgaaata 3214141 tatcttcgca tatgaataaa aatgcaagaa tcatgccatt ttcttgtctt ttgctgaaaa 3214201 aacttgttga atcgaacaga aatttgtcta acaggtgatc acctttctct ttttccgatc 3214261 ttgaacgcaa atttattttg cgttttttgc tctttacgca aaaaacaaat gcaaaattat 3214321 tttgcggagg cttctcaaat tagacccatc cgcggaaacg cgatgcttct gccgattttc 3214381 tgatgcccgt catgtaagcc gccaaacgca tatccacttt atgtgttgcc gctgtttgat 3214441 aaattgtttc gaacgagctg accatgacgc ttctcagttt ttctgcaacc tcttcttccg 3214501 accaataata tccttggttg ttttgcaccc attcaaaata agaaaccgtg acgccgccgg 3214561 cactcgctag gatatccggc acaagcagca cgcctctttc attcaggatc ttagtggcat 3214621 caatggttgt cgggccgttc gccgcttcaa cgacgattga cgcctgaatg ttatgtgcgt 3214681 ttttggctgt gatttgattg gagatcgcgg caggcactaa aatatcgcaa tccttttcaa 3214741 gcagctcctc atttgtgatg acgtcagtaa ataaattggt gaccatacca aagctgtccc 3214801 gtttatcgag caaataaggg atatcaaggc cgtctgggtt gtagagcccg ccattggcat 3214861 cagaaatccc gatcaccttc gcgcccgcat cgtgcatgaa tttggccagg aagctacccg 3214921 cgtttccaaa gccctgtatg atgatgcgcg cgttttgcag cttgatccct tttttcttca 3214981 ccgcctcttc aatacaaatc gtgacgccct gtgccgtcgc tgtttcccgt ccttgcgatc 3215041 ctcccaaaac aagcggttta cctgtaataa agcccggaga atcgaattcc cgcagccggc 3215101 tgtactcatc catcatccac gccataatct gcgaattggt gtacacatcg ggagctggaa 3215161 tatcctttgt cggaccgacg atctggctga tggcacggac ataccccctg ctcagccttt 3215221 ccagttctcc aaatgacatt gtccgcggat cacaaataat accgcccttc ccgccgccgt 3215281 aaggaagatt ggcaatcccg catttgagcg tcatccaaat ggataatgcc tttacttcct 3215341 cttcattaac ttctggatgg aagcgaacgc ccccctttgt cggaccgaca gcatcattgt 3215401 gctgtgaccg gtagcctgtg aacactttga cgctcccatt gtccattttg accggaatgc 3215461 ggacagtgag cattctctgc ggctctttca tgagttcata catatctccc ggataaccca 3215521 gcttccgaag ggcttcctta atgattgttt gggtagacag aaataagtta agagcttctt 3215581 tttcttcatc tttcgagact tgctttgctg acatcttttt cacctcattg tttttttggc 3215641 cggctgtaat gtaagcgctt taaaaaatca gcccgccaat tcctttcttc attggattca 3215701 cccttatcat catgcaagat ccgtaccagc ttttgaatcc acaaaaaaag agactgaaaa 3215761 catctcagtc tctgactaca aatctatcga ttaacgggga tcaatcacca gctgcgtttc 3215821 agcataaaaa ctgccgattc ccaaaccgtt tactacatcg cctttaatcg tgtaagtgcc 3215881 tgcgcgagga agagttttac gcaccatgac aaggtcaaat tcggatgcgc ctaacaaatc 3215941 aagcgtaagc gggagtctga ctgtttttcc atcgtttaaa atctgtgttt ctttcagtgt 3216001 tcttccattc actgaatctc ttgtcgtagc atgaaacccg tcaggaaatt gaaattctac 3216061 cgctccaaga gaaagcaccg catttggttt atatgtcact tcaatatcag aaatggtcca 3216121 ctctttcgtg ctgttaactg tttttgcctc gattgatgca gactgtgcat gagcttggcc 3216181 cgaaggaagt aagattgata gtaaaacagc tgaactgatg aataatgaag atacgaatga 3216241 agttcttttt agcatgacat ttccccctaa ttgattgttg aaatttggcc agagcgtcct 3216301 ctgcagaaaa agcgcttttt cataattcgc gaattaccag ttctttttct taaaaattaa 3216361 tctatcatca ttttccatgg aagtaaatgt tttttaagga atattaacac ttggaattca 3216421 atgagaattc cttcctgttt atacaaggtt caaatggacg atttccctct ctttttctag 3216481 taacatctgc ctgacatttt atatctttta tcctatttta aaaaagggca aaaaaagtcg 3216541 aagatgcctc tgctcttcga ttgatcacgt tcctattttt atctgaattc agtgttccag 3216601 ttaaaaccga tcgtctcatc atcccacgga attctttttt catcaggctg atccgggtta 3216661 tacgacatgg tggtaaaata gataattgtc agcggcgtct ctcccagcac tctatatccg 3216721 tgagccaccc cttttgggat taataacagc atcgggttgt cttcgcccat ataatagacg 3216781 tccgtttctc cttttgtctt tgaatcctct cgaagatcgt ataggacaac ctgagcgtgg 3216841 ccggttggga agaaccagag atcatcctgc ttctcatgat aatgaaatgc cttaatcaca 3216901 cccggatagc ttttcgacca agaggcctgc ccaaaatgct caaggagatt ctcatcgtcc 3216961 cggaccagct cagcaaaaaa gcctctgtca tcgctatgct tcatcaattt tttcaccttg 3217021 actccatcaa tcacacgcac tgctcctttc ctgcaaatac tctcgtaacg cttcccgcca 3217081 gtggcggggg cggatgccgg cttcttcaat agcccgatgg ctcagcacag agtatgccgg 3217141 acggggcgtt ttgttcccgt attcctctgt cgttacagac aaaatggctg tttccagccc 3217201 gctttcttcc ataattgccg tcgcaaactc ataccagctg catatgcctg aattgctgac 3217261 atgatagatg cccggcggat ggctgaacag cttgatgacc gcttctgcta aatccttcgt 3217321 ataagtcggc gaaccaattt gatcgctgac aacccgaagc tcttgtttcg tttcagcaag 3217381 tttcagcatg gtttcaacga aattactgcc gccatgtccg tacacccacg atgtcctgat 3217441 gatcgtgctg tcttttgtcg ttaatcgtat cagttcttct ccgagccttt tgcttttgcc 3217501 ataaatggtt ttcggatcga ggggatcgtc ttccctatat ggctgggttc ctttcccatt 3217561 gaatacatag tccgtgctga tatgaacata ttgagctccg atgcgggttg actcaagcgc 3217621 tgtataataa gcgccgattc cgttaatcaa gtacgcttta tcaagctctt tctcgcattg 3217681 atcaaccgac gtaaacgcgg cgctattgac cacgatatcc ggctgataat ggccaaacga 3217741 atgccgtact gagcgctggt cagcaatgtt catcatcttc tttgttaacg caatgacctc 3217801 atatccggct tgcttcagct ggcggcatag ttccaagcca agctgtcctc ccgccccagt 3217861 caccaatacc tttgtcaatc agatcacctt ctcatcggtc attgtctgta taccactgaa 3217921 tcgtacgcgc aatgccttct tcaaacgtca cttcctgccg ccagcccagt tcgtttttca 3217981 gctttgatgc attgatcgca tagcgccggt catgcccttt tcggtcttcc acgtgggcga 3218041 acaattcctc acagcccaga tgcttcaaaa tgacactcgc cagctcttta ttcgtgcgtt 3218101 catttccgcc gccgatgtta tacacctcgc cgtcggtccc tttttctaaa atcagcttga 3218161 tcgcgcggca atgatcctcc gcaaacagcc agtctcggat ctggagtcca tcgccataca 3218221 gcggaacagg caggccctgc ttcgcatgac ggataatcgt cggaatcatt ttttcgctgt 3218281 gctgataagg tccgtaattg ttgctgcatc gtgtaatgat ggccggaagc ttgtgggttt 3218341 tcacataaga caacacgagc aaatcagagc ttgctttgct ggctgagtat gggttattag 3218401 gagaaagcgg cgtcgtttct gtaaacgcgg gatcatccgc ttttaaatcc ccgtatacct 3218461 catctgttga aatatgaatc agcttcttgg cttttccttt caagaccgct tccgccaatc 3218521 ggtatgtccc catgacattt gtggtgataa acggctccgc ttgggaaatg cttctgtcca 3218581 catgcgattc tgctgcgaag tgaatgacgc catcgtaggt ctcgtcaaaa gcgcggtcga 3218641 tatcctcctg aacgctgatg tcccctttta caaagcgaaa acggctgttt tgctttaatt 3218701 tttccatttc ctccgggtgg ctggcgtacg tcagtttatc taaaacggta atgcgcgcat 3218761 ccgtttccct cagcatgagc tttgtaaacg tgagcccgat gaagccggcc ccgcctgtaa 3218821 ttaaatatga ttttgccatc acttttcgtc ctgtcctttc cgtaaagcct ggtgtacaag 3218881 ctgggaagcg agataaagcg attcgtgagt tccggcatct acccaccagc ctgataacac 3218941 atcatacgta agctggctgt tttcgatgta tagattattc acatcggtga tttccagctc 3219001 gccgcgcttt gatggtgata tttgttcaat atatgaaaac acctctgcat catacatata 3219061 aatgccggta acacaaaggt tggtcggtgg ctgttcgggc ttttcgatga tggaacgaat 3219121 ccgcttgttt ttctcatcaa tctcagcaat cccgaaacgt tccgggtcat caacttcttt 3219181 cagaagcact tttgctcctt tcccctgctg ttcaaagcgt tctgtataag gctttaatga 3219241 atcttcaaat atattatcac ctaataataa aatgaaagac tcttttttcg taaagcgctt 3219301 tgcataagac agcccatccg aaatgcccga tgctgccggc tgtacttgat aagtgatagt 3219361 aacgccaagc tcttccccgt tcccaagcag tttgtaaaat tgcggcatat gctccttttg 3219421 gctgatgagt aaaatgtctt ttattccggc ttcctgcagc ttcataatcg accagtatat 3219481 catcggatac gggcctacag gaagcaaatg cttgttgacg gctttcgtta agggcataag 3219541 gcgtgagccg tttcctccgg ctaaaataac acctttcaca ttaacacttc cttacatgca 3219601 tttttatatc tcttgttcat ataaatcttg aagaatagct gttacccgta taatgccttt 3219661 gccatccacg agcggccttc ctcccttgtg caaagaaagg cgaagaggat agctgctcat 3219721 aatgcgtgac atctgataga tgagtgtttc atccggtaca agctcaccca atccaagatc 3219781 aagagcggcg ccttggtcag caaatgtttt ggctgtagcc gtttgatgct caacctgaga 3219841 aagaacaagg cacggcacgc cgatgcaaat ggcttcatat agagagatgc cgccagcgac 3219901 aatggctgcg tccgcttgtt tcatcaaacc tgccatatca tttgtctgtt cgatcatctt 3219961 gtactgcggc ttcttttcga tccgccttcg gactgcctct tgatgcggtg aagcgctccc 3220021 catcacaaac atcatgtttt tgtcttttat gtcggggact tgatcagcgg cagccagcac 3220081 tttaaaaata agctgcttcg gatcacttcc tcctaatgca acaaggatat tgcggcagtc 3220141 tttcttaagt gtgtaatcct ctcttgcggc ctgaaaggcg gggtgaagaa taagatagtc 3220201 cggaccttca tagatgcgtg tgtttccctg aacgtacacc ctgcttctga tgtcaccgta 3220261 aattccgtta atgactgcgt cactatattg aatcgattta ccgtttttct cttcaaaaag 3220321 aacaattttc gcatctgtct ccgtctttat tttctttaac agctctgcag gcgcgcctag 3220381 aatatcaaac aaaagcaaat caagcttctt gctttttatt tcccggagaa taaattcgtg 3220441 ctgctgcagc tccggcttta cgatgacctg ccaatgctct tcatgaagaa acgcttcaga 3220501 atcctgattc gtataaaacg taatcaagca tcgctgtttg agcccctccg caagcctctt 3220561 catccggaca acatggccca ttcccttttc atagccgccg tctgcgaaga tcccaacatg 3220621 catggctagt cagcctctcg ttcggttgcc gcatcggggt tccggttcag aagggtgata 3220681 agctctgagg cggatacatc ggggcgctcg cctgcttttt gatagagggc ctttatcgat 3220741 tcatagtctt cctttgtatc aatggtcagc cgatattgag gggcgcgaaa tcgttccggc 3220801 gcctctaaaa actgaacacg ataaagagct ggatgattcc ttatatataa cgtgacatgc 3220861 tcctgatatt gatcctccaa agcctgaata cggctgatgt caattaacag gttggcgttg 3220921 accacttcgc cgcaaatccc taatggggca ttcaggatat acgtataatc cgagccttga 3220981 tcaaaatgcg cctgaatcat tacatcgagc agctcaggat cgacaaacgg attatcacct 3221041 gttaaccgga tgatgactga cggtttaaca gcttctatga ccttcacaaa cctatcgagg 3221101 acacgttctt cgctcccgcg gaaaacacga aagccttgtt tgatacagtg cgcctctaat 3221161 atgtcgtcag tttctttgtc agacgtggcg atgacaagat tatcccgatc cttttggtaa 3221221 aacgcgcttt gccggacacg gtgaacgaga atatcaagta aacgattcga tccgagcggc 3221281 cgaagcactt ttcccggaag ccttgttgaa cccattcttg cttgaatgat aaagagaata 3221341 tcattcatga aacgggctgt ccttcagtaa aatgtcatcc cagacaatgc ctgtgtcggc 3221401 tggaatgtct cttacagccc gaacaccgct ggtcagcagt tcaaaaaatc tcgggtgcag 3221461 cccctgcggc ttttgtccgg gccgaagcac tgcgatattg tcttcactaa aggcttcacc 3221521 tttttgaatc ggagctgttg taaaaatgcc tctgtatgca aagtttctga tttctccttc 3221581 gatggcggtc gttgttttgt atgaactgcc aagcagtttt tcagagaccg gctttgtgat 3221641 cccctgtttc agctcagctt ccgttttcct gatgccatcg accatttctt tcaattcatc 3221701 cggatttaat gcaaacgagt ggtcagcacc cggcagattt ttatcgatcg taaaatgctt 3221761 ttctatcagt tttgctccga gccgaaccgc ggcacacggc gcttctgtcg gatgctcgct 3221821 atgatcggag aagccgatta ccgcctcagg aaaagcggcg gcaagcatcg gaatgacgct 3221881 gaggttgctg tactccggcg gtgctgggta tttcgccaca caatgcatta tggcaatttg 3221941 attgtttccc tctgccctga tggtgcgcca agcttcgtga acatcagaga tttcagctcc 3222001 ggctgtcgag aaaatcatcg gcctgttcag ccgggcgaca tatttaagca gcgggagatg 3222061 gttaatttca taggatgcga ttttaaaagc gctcggcgag gtagactgaa gcagatcagc 3222121 tgacccctcg tcacataccg tacttaaaaa gatcacctgc ttttcgcggc agtaatccaa 3222181 tagcggtaaa atccactcag caggcatttc catagattga accaaagaaa aaatagagac 3222241 gtccttgccc gctgccgtct tgtacaaacc aggatctttc tggtacatcc tatcagcttg 3222301 gaacatttga aatttcacgg catccgctcc cgcttccgcc gcggcgtcta tcagcgcaaa 3222361 agcctgatca agcttcccgt catgattaat ccccgcctca gcaataataa aaacaggagc 3222421 gtctttgcct acagttttat tcgcgatctg aaacgctgcc attatttcgc ctccttgccc 3222481 ggccaaatat gataatagta atacgattgt tcagcggtga agcccattcg ttcataaagg 3222541 cggatcgccc ttacattgtg aagctgcgtc cccgctgtta ccgttctatg cttctgggtc 3222601 tccggttgtt ctatgagatt cgccaataaa tgaaacgcaa tacgtttccc ttcaaatccc 3222661 ggctttacag ccatcaaatc gagaatgcac tcatcatctc ttgataagcc ctgaagatag 3222721 ccgatgacct cgccattgtg tttagcgaca atattgaccg ccgcccttcc attcagattg 3222781 tttcgtgtcc actcctgaaa tatttcgttt gctgcatcgc ggctgagatg aggatcctga 3222841 aaatatctgc tttttgtaaa cgagtctcgg gccagctcac atatcgcttc tgtgtctccg 3222901 ggctcaggcg ggcccagttc aaaaaatggc ggtgttttgt cataaaaaga cggaggcatc 3222961 gccagcttca gcaaactccc gacaaagtaa gaggatggct gctgttgtat cacatgcgcg 3223021 gctccgatat cttcagccgg aacacggaca aagataaaat ccgtttcatc catttggcgt 3223081 acagtataaa aagcttcaaa cagcctcttt agctgcccgg tactatttgc cgcaagaagt 3223141 ttgacgttca tgactttctt ctgaagcacc ttgctttccc acaaagaatc ttcgtaaagc 3223201 aatacgcctt ggagcctgct gttttcaaaa aggccgaggg aaaattgata cggaacatcc 3223261 aatgtaagct ttctgctttg gagaaattcc tcaattgcct ctttggagac attttctttt 3223321 accgtataca cttaatcagc cccttttacg atatcccgca cagcttcaat gacatcatct 3223381 acatcatcgt cagacattga tggatagagc gggagagaaa gggttcgttt atagtaattc 3223441 atggcattcg gaaagtccgc ttccttatat ccaaattgct tttgataata cggatgaatg 3223501 tgtactggaa taaaatgaac gctagtgccg atattgtatt catcctttaa agccgtaatc 3223561 atttcgctgc gcgtaacccc ggcctttttt tcatcaactt gcagaacata tagatgccag 3223621 gcgtgcctgc cgtcatcatg gacaaacggc gtgatcagcc caggaatctg ctgaaaagcg 3223681 gtttgatagc ggccggcaat ctcttctctc cgtttctgca tatcatccag ccgtttcagc 3223741 tgatgaagtc cgagggccgc ctgcaaatca aacatattca tcttatagcc gggcgattcg 3223801 acttcatagt accagctgcc atttgaagaa taacggttcc atgcggcttt actcatgccg 3223861 tgaaggctta gcacccgtat cttatcggca agctcctcat catcagtcgt cagcatgccg 3223921 ccttcccctg tcgcgaggtt tttggtggcg taaaagctga atgccgttgc atccccgata 3223981 gaaccgatca ttctttgctt ataagtcgta tataccgcat gtgccgcatc ctccagcacg 3224041 aataaaccat gattttgggc aacagccaat attgcatcca tatcgcagga ctgcccgcca 3224101 aagtggacgg gcacaactgc tttcgttcgc ggtgtgacgg ccgcctcaag ctttaccggg 3224161 tcaatattga gcgtgttttc gtcaatatcc gcaaacacag gcgtcgctcc cgtatgaata 3224221 atcgtattgg cggtcgagct gaacgtaagc ggagaggtaa tgacctcgtc cccgggccca 3224281 atcccttttg ctttcaaagc caaaaataaa gctgcggtac atgaattcac cgccacggcg 3224341 tgcttcgccc cgacaaacgc ggcaaactct ttttcaaact gctgaacctt cgggccttta 3224401 gagagccatc ccgattcaag cgtttctgta acctcctgaa tttcttcctt accgattaac 3224461 ggcaatgagt aagggagaaa atgatttctc ttttgcacca tttctttgcg ctcctatcat 3224521 tttattcagt atcttcccgc ctgtaatcaa cccctgtttt ggctttcagt tccgcaaata 3224581 aagcatttgt tgattctgcc accggataat tagccgctat gaatgccagg cgcgcctctt 3224641 ctgctttttg atgcacgtcg ggacttcgaa gaacctcaac caaggtgtgc gccagttcat 3224701 ccggctggtc aaacataaaa tcgccaagag actcataata cggatacgag cgatttccgg 3224761 acgattttcc tatcagcaca ggcttttgaa acagcatggc ttcaagaccg actgtcgagg 3224821 tttgcgtcac tgcggcatca acatacggca gcaaatcata aagctccagc tcctttttga 3224881 tgactctgca tgcttgatgt tttttcgccg cctcgtgata cagatcaagc ttgttttttc 3224941 cgatttccca cgggtggggt ttgataatga tttgcagctg cttctgatca gaaagcccct 3225001 gcagcacacc ggaataaaag tcttctgaaa agggctgagt ggcaatgagc acaatttttt 3225061 tagtcggctg aaaagcaagt tttcgataga atatggacat atccataggc gttctgttaa 3225121 aaatctgatc gaagcgggga tgtcccgtta cgagaatctg ctcgggttta cagccttttc 3225181 gtatgaacca ctctgcttca tacgcaccaa aaacagcttg ataggttgta aaaacaggaa 3225241 tgaaggcttc atctcccatc aatgcgccat gctgaagaca aatgctgacg gccccttttc 3225301 tttgacacat gagagcgagc accctgctgt aaatgtcttc tgccgttccg acaataacag 3225361 ctgaaatctt ttcctgttca aacagcgcat caactgtatc aatggcctct ataaataaag 3225421 gaatatcttt gaaaagccgg tcgcgaaacg cttgatcacc aaatgccggg tgatcatcat 3225481 aaggggcgag aagcgaacag gctgtttcga gatactgctt cgaatcgcct ttttggcatg 3225541 aatccgcaat ctcccgcttg ctaattacag gcagatcaca ataatgcggc aaactccatc 3225601 tggccaaaac agccgttttt tcaggatcaa attgatagta attttcgttt gaaaaacgca 3225661 ggtaatcaaa gtgcaaaatg actttccctt taacaggttc gtcatttgtt ttaacgatgt 3225721 tttggattct ttcttcaaaa aacggctgaa tctgtccctc atcgatatgc tgatccaccg 3225781 atccgaataa ttccggttct tcttccatca tcaccctcag ttcagggctg atgtattgat 3225841 aaaaattact gataagccca agcggaatcc ctttgtagcg aagtttgtca aaaagctcca 3225901 cgtacttccg gtacagcacc caataattgc ttaaataggc cgacaagctc tcaccccatt 3225961 ccaagctttt ttaatgattc acgcagctct cggcaatttc gctgcggagg aaggttcctg 3226021 acaaattcat ttttttctaa ttcaaacagc tgaaagtgaa tcgattggtc ggtaatataa 3226081 ttcaggtcca gctcctcatc cagtgggtaa aacggataaa aatgattgac tctccaaaag 3226141 aaccgggcat ctcctatacg gtaaaacgcc gggctttcat cccaatagga gccaaacttc 3226201 tcctttacct tctcaagcac cgaatacctg tgcatcaccg agcaatgatc aattgcgcac 3226261 ggcgcgttcc atgtcacttg agcggcaggc ctgacagttt cttttacaat gtcacgattc 3226321 tcgtttaaat gataggtttt ggaggctgag taaatcacag ccttttcagg atgggtatcg 3226381 agctcccgca ccattttcag gaggcggtcc ggcatataga tgttgtcatc cgtcgcatag 3226441 gtgatatatt caccctccgc catctcaatc gcctgattga tcagtgccgc gtatctcgtt 3226501 ttttctgttc tttccttcac tccagatata tcgctttgat aaaaacgcac tcggttatca 3226561 ttcaaaaaag gacggattac attcagcgtc tcttcattgg agttgtcatc cataataaac 3226621 aattcaaaat ctgaaaacgt ttgtgagagt atgctagaaa tggactttgc cacataatcg 3226681 cttttgttat agctcgtcat aatgactgat actttaggca aatcctacac ctccttcttg 3226741 gaacttcaca cctgaaacta tcgttatctt atgttgctta tgctcaagtt gcgctaggga 3226801 tacaaaccaa tatgcgaaaa gtttgtgtat gtttctgaaa aacagcggct gcccagagcg 3226861 aaatctgatc ggtccgctgt tctttttcag cataatccaa gcatcagcct cataaggtga 3226921 aagagataaa aatcgcacca gcgactaaga tcgttttcca tcggaggtga gtcatcgcgg 3226981 agcgttcacc tatacatcca gaacatgttt tgaatggttt tcataaaaag gaggaacgat 3227041 atgaaaccga aaaaaaatca atatcagcaa atgcaggcat ttgataatat gcaggggtat 3227101 cagcctcagt ttggcgccaa cccgtacccg cagcaaggcc aaggctcaca aatgcagaca 3227161 atggggatgc agccaatgat gccaatgcag cagggacagc aaggacaaca aggacagcag 3227221 ggatttggat tcccgggcca gcagcagggc ggcggttttc aaattccatc ggggcctaca 3227281 ccgtcaggac cgggccaaag cgttcccggc atgctgcctg ttgaggaatc ttacatcgag 3227341 aatattttgc gcctgaatcg gggaaaaacg gccaccattt atatgacatt tgaaaacagc 3227401 aaggaatggg gctcgaagat ttttcgcggc gtcatcgaag ctgcgggccg ggatcacatt 3227461 attatcagcg acccgaaatc aggaacacgc tacctgctcc tgacaatcta cctcgattac 3227521 attacatttg atgaagaaat tgcttatacg tatccatatt ccatggcgtc ctattcgcca 3227581 agataagaaa aaagccaatc actcatatga tgaggattgg cttttttgtt tatagatatt 3227641 tgacggctgc gacaacgatc ataatccaag aaataataaa cgccacaccg ccgagcgggg 3227701 tgatcgctcc aagaatggag atttgcgtca cacttagaat atataagctt ccggaaaaca 3227761 gcacaattcc cgcaaacatc agccagccgg ctgtcgtgac actgcctatg ccggataatt 3227821 tatcagccag aaacgcgaca acgaataacc caagggcgtg atacatatga tactgcacgc 3227881 ctgtgtgcca aacctgaaga tacttatcag gtattttccc ttctaatccg tgagcgccga 3227941 atgctccgag tcccacggca agcagggcgt taatggcccc taatatgata aaaactttca 3228001 tctatctctc ccgccttttc gttaaactca tatcatttat cttatcgcac ctgcaccaaa 3228061 attcaatgtt tgttctccgt tgacacgaga ttgtcggatt ttctcctgcg ccaaagctgg 3228121 aactggtcag ctgctattgc agcaagcgtc cctaatacga gcccgttgct taatagagaa 3228181 ataaataccg gatgcaatcc ctttaacgca gtttcaggaa caaacatgat accgacccct 3228241 gtcagcagtg agataccgat gatagacctc accctttttg attcttcttt ctcatatgaa 3228301 tcaaattcgg caaaggccag accgcccatt gcggagaaca caacaaaatt caccgcaaat 3228361 ccaacgggtg acggcaggct cgcaaacgta ttcataaaaa acgggatcac gctgatcacg 3228421 ataaccagaa tactgccgag cataaacggt tttttagaag gcatcttggt cgtttcaata 3228481 aaacctgcgg ctcccgaaat cggaacaggc gcaatagctc ccgtcaaacc gctaagcaga 3228541 tggctgaatg aagctgcaaa accggcatgg cgttcatgat gctttccatc aggctgtttg 3228601 ctgaattttt tcatggcgat gtccacgacc ttcatgctcg ccagcatatt cacgatcagc 3228661 aagatggtaa taaaaataga agtgatgatc aggccgctgt taaataacgg ggtcccaaaa 3228721 ggaaacaggg aaggcagctg aaacagccgg tccggcattt caatcggctt tgcggctccg 3228781 gcagccgcaa acagcaccca cccgccgaac aaggctaata aaatagaata ttgcttaaaa 3228841 aacatgatgt tcgaatttgt cattataaaa gcggcagcga tcacaacaag cgccaggcca 3228901 aatacaagac cgtccacccc gtcctgtcga taaccgattc cgagaattcc ttttataatg 3228961 ggctgactca gctgcatgac aagaagcaat aaatagacgc ccgttacaac cggagtaaac 3229021 aattttgcaa gtctgtcaat gaccttgaaa acacttaaca aaaagaaaca tacagcgctt 3229081 acaagaagag ctccctgcaa accccgcagt gtgtctccat atgtcgcaaa cacagttccc 3229141 gtcagccctg cgtaaatcgt atacactccc caccacaagc cggctgggct ttcattgatc 3229201 ggcagtctgt ggcctttcaa acactgaatg acggcggcaa ttcccagtac aaaaaaagtg 3229261 ctttgaatca atcttgcaga atctgagtga tccagatgaa acgactgggc aaccgccacc 3229321 ggaacaacaa tcgccgcagc aataataaac gctgtccatt gcagcgcgcc aagaaccaat 3229381 ttcacgtaag ctcaacctct ctctttaaaa atcaaataaa gactctccgt ttccatcctc 3229441 ttcctgcttc tctttttctt gctttcgata tttgtttaat cccgcgctcc ccatcatttt 3229501 ttccatcatc agctggtctg tcgatggcgg cgcggcggga cttggcgtaa cgctcggctg 3229561 tatgcggggc gcgctcgcgt tctccggctg atcaagcacg acatcacaca gagaacggac 3229621 aaccgctaca taacgcttca gctcctcatc ccgttcagcc gtttttgctt tttttagctc 3229681 ttcttccatc ttttgaatca aagcagatat atgaatgttc atgaagcacc ctccaaaaaa 3229741 ataaatgttg tcttcctgca ttttatcaaa ttcctgctga aaacgcagat atgagtttgt 3229801 tattttttct gacaaacctt gcgcgattga caagcagaag agatttttca cataataaat 3229861 caccatacct tacaaaaagg agaaacggaa tgaacagcat cccctctatc atcagcaagc 3229921 ataaagccta ttttgcggcg ggacatacga gaccgcttga atcgagactg aacattttgc 3229981 gaaagctgaa acaagccgtc agaactcatg aagccgatct catagccgct ctctaccagg 3230041 atctccataa atccgagcaa gaagcatact caacagaaat cggaatcgtc ttggaggaaa 3230101 tcagctttgt catgaaacgg ctgagaaaat ggtccaagcc gaaacgagtc aaaacgccgt 3230161 tgactcatct aggctccaaa agcatcatca tccctgagcc gtatggaacc gttttggtga 3230221 ttgcgccttg gaactatccc ttgcagctgg cgctttctcc gttgattggc gccattgcgg 3230281 cggggaacac ggtcgttctc aagccatcag aatatacgcc ggctgtttct gctattcttt 3230341 ccaaactcat cagcagcgtt tttccaactg attatgtcgc tatggcagaa ggcgggcccg 3230401 atgtcagcac agcattatta cagcagccct ttgactacat tttctttacc ggcagtgtag 3230461 ctgtaggaaa aatcgtcatg gaggccgccg ccaaacaatt aattcccgta accttggagc 3230521 tcggcggcaa aagtccctgc atcgtccata aagatgctga cattcagctt gccgccaaac 3230581 gcatcgtctt cgggaaattt acaaatgcgg gacaaacctg catcgcaccg gattatttat 3230641 ttgtccacga ggacatcaaa acgaagctca cagaagaaat gaagcgtgcg atcagagaat 3230701 tttacggccc tcagccggaa cggaatccac agtacggcaa aatcgtcagt gagcgccact 3230761 atcagcggct gctcagcttt ctgaatgatg gcatcccgct cacaggcgga caatctgatc 3230821 ccaatcatca caaaattgcg ccgaccattc tcgaacaagt gagagatgac tctccagtga 3230881 tgcaggagga gattttcggg ccgattcttc cgctctttac ataccgcaat atcggggaag 3230941 tcattgagaa agtccaatcg cgccctaagc cgctcgccct gtatctcttc accacaaaca 3231001 aagaaattga gcgcgctgtt ttaggaaatc tgtcgtttgg cgggggctgt gtcaatgata 3231061 cgttaatgca tgttgcgacg ccgtatttgc cattcggcgg cgtcggggaa agcggcatcg 3231121 gcagctatca cgggtttgac agttttaaca cattcacgca caaaaaaagc gtcgtcaaac 3231181 aaacgaaccg tttcgacttc gcatttcgtt atccttcctc caaaaacggg ctgcgaatga 3231241 ttcgaaaaat actcaaataa aaaagcgcag atcacctgcg ctttttacaa atccttaata 3231301 caccaatcaa tcggcgcctc tcccattttc tccaaatagg cattcgcccg ggaaaacggt 3231361 ctgctcccga aaaatccgtt tctcgcagaa aacgggctgg gatgcgtcga ttcaatgata 3231421 aaatgcttgg aggtgtcgat ccgttctttt ttcatttgag catgccgtcc ccacaaaata 3231481 aagataaccg gccgctctct ttcactcagc acgtcaataa ttcggtccgt cagtcgctcc 3231541 cagccttttc ccttatggga attcgcctgt ccgcgcctta ctgtcagcac agtattcagc 3231601 aaaagaacgc cttgctttgc ccagctcaca agcgacccgt gattcgggat gctgcacccg 3231661 atgtcctgct gcagctcaag aaagatattt tttaacgaag gcggctgctt tacaccgggc 3231721 ttgacagaga agcttaaacc ttgagcctgt cccggcccgt gatacggatc ttgacccaaa 3231781 atgacgacct tgacatcatc atatgatgta taatgcagcg cgttgaaaat atcccggctg 3231841 tccggataaa tcgtttgctc cgcgtattcc ctcttcagca tctctctgag ctcttgataa 3231901 tacggtttct caaactcttc ctttagctga ttccaccagc tgtcttgtaa aagctgtttc 3231961 aagattcagg cctccttacg aacgatgaag tctggaatag acaggctcgc catcccaaac 3232021 catttcactt tttgcttccc gcctcttcat ctcaggctct tcaagcagga cggcaaagtt 3232081 tttcgtcggc agctccccga gtccgtgctt ttcacttaaa cgatccaaat attgcttccg 3232141 cttggcgcca aggtcagcag actgattgtc tcccgcgtca ctgaaggcat aaatcacgct 3232201 ggcgcaaggg acacgcttca cccggtaatc cttggccgcg cgcaaataaa aatcccagtc 3232261 ccagtaattg tgcacatcag catcgaaata cccgatttca tcatgcagaa aacgtctgta 3232321 catgctgccc gacggcacgt atgtagaaaa cactctcata tcctcatagt cagcggtata 3232381 agcaaacaat ttccgtgaca ctggatacct tgttccgttt ttctcttcaa acgaaactat 3232441 ttccgcatca gaatgaacga agtctgccgt ttctatttcc tttgccattt tctcgatatg 3232501 ccctggcgta aagaaatcat cgtcatcaca cagcataatg caatccccag acgcctcttt 3232561 tacaccggca tttctcgcag ccacatgccc cgagttcttt tctaaattga tgacagcaat 3232621 cggcagctcc ggataaagtg ctttgaccgg cacgaccgat tccccggcat cattcacaat 3232681 aataatttca tacggcatca aggtctggcg ggaaatcgac tccaaaagct cacacaaagc 3232741 cggaatccga ttataggtca caattacgat agaaatcttc atgatgctct ccttctcatt 3232801 ttcatagtca tgtactatta aaacatatat tggacgggag atcagtggga atatcctact 3232861 gaaacggcat actacaatga tagaaacagc aaagtggctc cgatcagaag caccatgatc 3232921 agcatcagat ctccaaagac atgaaagata tctttcatgc ggacgccatt cggaaggata 3232981 agacgccaca gcttagattg atagaccggc agcagcacca gtgcataaga aagacacaaa 3233041 aatgtaaaag ccggcggcac aaaagcacag cctgcatcgt cccaattcat catgatgtct 3233101 ttcatactag atccatccaa taaaaacaaa gatatcatga gggctagcaa cacaaaggac 3233161 cccaattgaa cctcaaacag gcgcattttc tggttatatg caaatcggac cgcccaaaac 3233221 cagacataag catatgaaca tagcagcgta agaatggcac ctgctgtaaa gacgacatca 3233281 ggcagccgat caagcagaaa aacaaaaggc aagctggctg ccatagccaa gagcatgcag 3233341 ccaccagtaa acaaaaatac tgccccatga gctacaaaac catataaaca agagctaatc 3233401 ctcacgacat acacctcctt tacatagaaa ttctatgtat atacctaaaa aatcagacaa 3233461 gctgacgcct gccaatataa cagcccattc ggccaaataa cggaaataac agcgttgcaa 3233521 aagcacaagt tccaacaaac caaggtgtca acaaggattg aaacagcgca gcaggaatta 3233581 cattgaatag aaaaacaagc ataaaaatga cgtttggcac cattgagatc agaatcgtat 3233641 gtagaacaag cttttctccg cgttttccaa actccttcac gccttgatac ccaatcagca 3233701 cccagtagat catatatgca gctaagatca gccaaacaga aacagaaatg cctttccata 3233761 ctgcttgaac aaacggtgat tcaagccata catgcattat tgtaatcgca atgccgacag 3233821 cgaatagggc actgttacag aaaagatgga acatcaaaaa cgcacgaaac gttactggct 3233881 gtattttctt aaacgaagaa acaatgtcag ttggtgttcc aaacgcctgc aataaagtct 3233941 gcatagcttc ctcctcactc tttccttcct gaaaagagcg aaacagatga tgttcaatat 3234001 ggctctcaat ctcttctatc atcgcctcac cctcaggaag ccctttaagc ccgcttttga 3234061 tttcggatac atatgtttct ttatccattt tgtccgctcc acttcagtat tcggtccatc 3234121 atggctgaaa atacgctcca ttccttcgtg cgttccgcca gcacttcttt gccctcgtct 3234181 gtaatccggt aatatttgcg gtccggtcct ttctcctgct tctcccagta ggaagaaata 3234241 tacccttggc gttcaagctt gtgaagagaa ggatacaagg tcccttcttt catctgcagt 3234301 tcatttccgc tgcggcttcc catttctttt acaagctcat agccgtacat cggccgctcg 3234361 ttcagaagcg tcaataccaa tataaccgtg cttcccttaa ccagctcacg atttaacatc 3234421 tcaaaacccc tacctagttt tcttatgtag cattttacga aagcccgttg agattgtcaa 3234481 atgattccta tagatcttct atattgtgat acagagaaaa tctaactata atgaaagaca 3234541 aaacatgatg gaggttcaag acatgtctat gcataaagca ctcaccattg ccggctcaga 3234601 ttccagcggc ggtgctggga ttcaagctga tttaaaaaca tttcaagaaa aaaacgtata 3234661 cgggatgacc gccttaacgg tgatcgttgc gatggaccca aacaacagct ggaaccatca 3234721 ggtattcccg atcgatactg atacaatccg cgcccagctt gcaacaatta cggacggcat 3234781 cggcgtggac gccatgaaaa caggaatgct gccaaccgtt gacattatcg agcttgcggc 3234841 aaaaacgatc aaagaaaaac aattaaaaaa tgtggtaatt gacccggtta tggtttgcaa 3234901 aggtgctaat gaagtccttt atccggagca cgcccaagcc ctgcgtgagc aattggctcc 3234961 gctagccact gtcattacgc caaacttgtt tgaagccagc cagctcagcg gcatggatga 3235021 actaaaaaca gttgacgata tgatcgaagc cgcgaaaaaa attcacgcac tcggcgctca 3235081 atatgtcgtc attacaggcg gaggcaaact caaacacgag aaagccgttg atgttctcta 3235141 tgacggagaa acagcggaag tccttgaaag cgaaatgatc gatacgcctt atacacatgg 3235201 cgcaggctgt acattctcag cagccgtgac agcggagctt gccaaaggtg cggaagtcaa 3235261 agaagccatt tacgcagcga aagaattcat cacagcggcc attaaagaat ccttcccgct 3235321 aaaccagtat gttggtccta cgaagcattc tgcactgcgc ctgaatcaac aatcataaaa 3235381 aaaggggctg ccttacagag aggcagccct ttttaaatca ccgaagactt ttcacagaaa 3235441 aaactgccga tcccatcggc agcctgttta tttgattttt aaattgtttg cagatttcct 3235501 caaaaatgtt tctatcgact gaacaaaaag tgcatattcc ttcatttgtt catatgcccg 3235561 cgtgagaatt tccgccgttt cactgtgcgg cgttgttccg ccaagcattt ttttcagctg 3235621 aagcagcaca tccttatatt cttctcgctt atcttcaact tggttagcag ccttttccaa 3235681 acattccggt gttatcttct gttcatgtat attcaagaaa acaactcctt ttacagaaaa 3235741 aaatagtagg ttatcgttga agaatagcac agatggctca gatttcacat aagaaaatag 3235801 aaggattttc tacataagtg tccaaattcc gacattcatt tcagatttcc cggtcgcact 3235861 ggctgttact tcatgatttc ccgggaaagg aaaatatctt gcactcaaga cctcttctcc 3235921 gttattgata aagatttcca cagatgacgc gtcgagaaac atgtgtacgg tatgcaaatc 3235981 cttgatgcgg caatgtctcg cttctgttct ttttccgtca aagctctttc gttccagcgt 3236041 aacaatcccc tcgtctttat ggaaggaaaa cgtagccgtt ccgcggatac tgattgaaaa 3236101 gccagactcc gtatgaatgt cttccagtag aatctcagtt ctttcaggtt tttccactgg 3236161 aagcgcacca gatgatccat gcatgttgat gtgtattttt ttctcatttc tgcgcatggc 3236221 ttttagctca ggcagcggct gctgaatcag cttctgtcct gaaagcgtca gctgtctcgg 3236281 cagcgtcatg cagtgaatcc agtggcagtc aatggtcgga tgggaccctt catcctgatc 3236341 aggcaccgcc atccatgcaa ataaaatccg ccttccctga tcgtcttcaa gtgtttgcgg 3236401 cgcgtaaaaa tcaaaacctt gatcaagctc cgtaaattca ccatgcttca gttcaggctt 3236461 gttataatcg aggcggccga caaaataacc tgattgatat acgttctgat aacggaaacc 3236521 gtcagcctca agcccttgag gcgaaacaat cagcacatcc gatccttgaa gggaaaacaa 3236581 atcagggcat tcccacatgt atccaaaatc gtccagcccg ttgaagcccg cgccggttat 3236641 cgggccaaga aatctccact ctgtcaggtt atcagaagca aacaacacag cctgcccttt 3236701 caaattctct gtttgcgcac caatcaccat ataccatgtg ccttcatgct cccatacctt 3236761 cggatcgcga aaatgcgccg tatatccttc cggaaggcgg gcgacgacac cctttttctc 3236821 aaaggacagc ccgtcgtcag aaacagcaag gcattgatac gtttcccgat ttccatcctg 3236881 atccctgaca tttcctgtgt aaaaaagata gagccgatcg tctttcgtga cagcgctgcc 3236941 cgagtagcag ccgtttttat caaaccaatc actcggagcc agcgcaatct cttcccgctt 3237001 ccaattcaca acatcctgtg tcgtataatg cccccaaaat tttgcgccgt gccccgtctg 3237061 aaacggctgc cactgaaaga atacatgata gctgcccttc caataaatca cgccattcgg 3237121 gtcattcagc agcccaaccg gcggcatgat atgaaaatgc tggcggtgcg gatcgctgtt 3237181 agcgatgggc tcttttttct ccacttcttc ataagcccgg cgacgaagct cctggtcatg 3237241 tgctgtcatt ttttcctctc ctcatcctca ttaatcttca tgacaaatgc tgcaatgaac 3237301 gctgacactg ccgcaatcgc catgccaatc agatagtgaa tcaagttgct gaagccaaac 3237361 ggagccgcaa tggcgatcat cggaattccc gttaacccgt aagcgtttgc agctacatgt 3237421 gtaaagacga catatgcccc acccaatgcg cctccgatca tcgcggcgat aaacggtttt 3237481 cggtagcgca gattgactcc gaatatgacg ggctcagtaa tgccgagaaa agcggaaaat 3237541 gctgccggaa gcgcgatttc ttttgtcttt gcctttttcg ccataaagaa gacggcaaga 3237601 cctgccccgc cctgtgcgac attcgccatt gaccagatcg gcagcaagta gtttttgcct 3237661 atatctgcaa ttagccctgc ctcaatcgca tggaagctgt gatgaacgcc tgtcagcacg 3237721 atgagtgaat acgtgccccc gaaaatcaga cctgcgacaa aaccggcatg gtcatataca 3237781 taagttaaag caaccgtaat gccggagcca agcgctctgc ctagagggcc aatcgcgata 3237841 aaagcaacaa acccggtgac aatcacagta acaaatggtg taacaagcaa atccaccgca 3237901 tgtggaacca cttttctcgt ccatttctct accttgctca tcacatacac cgcaagcagg 3237961 acagggataa cagttccctg gtagccgaga agagcgatat caaatccgaa aagatgcatg 3238021 taatcaggtg tcgcttccgc caatccccat ggatttaaaa gattcggatg aatcatgatt 3238081 cccccgatga ccgctcccaa gtatggattg ctgccaaact cttttgaagc gctgaccccg 3238141 attagaatcg gcaagaaaat gaatgctgca cttgaaaaca tatcaagcag ctgcaaaagc 3238201 gcagaatcct tgctcatcca atgaaacgca ttgatcatac ccagcaatcc cattaatagg 3238261 ccgctggcta caatagctgg gatgattgga acaaaaatat tagaaagcgt tttcgcaaat 3238321 ctcgcagcgg gattcagctt ttcttttgcc gcatcctgat gattgacgtg ttcttcacgc 3238381 tcgatatcag cttctttaga aaaggcatcg aatactttat tcacaaggcc tgttccgaaa 3238441 atgatctggt actggccaga gctgctgaaa gcccctttaa cgccatcaag ctcttctact 3238501 tgtgcttgat ctatctttga ttcatctttc atcactaaac gcagtcttgt tgcacaatga 3238561 gccgcgctga taatattttc tttccctccg agaagctcaa tgaggcgttt tgcagtctct 3238621 ttgtaatcca tctatttctc ccccttttat ttaaacaaaa aagacctaaa attcgccaac 3238681 gaataaagga cacagcgatc ctttttcatt tacgcaaatt ttaggtcttg cctgctttac 3238741 cagtcacaat cccgcttatt cagattaaga atacgctttc atcataaatc atgatagcgt 3238801 tttcgtcaac tattttttta gttaaatagt ttgatataac atgtagacaa aaattcgtaa 3238861 aaattaattg tgaaatactt cacaatatcg tgctatacta tgctcaatca tgaaagaaag 3238921 caggaaaaga caatggaaac tcaagcatta caaaaggttg aacagtatgc tttgaaaaaa 3238981 caaaacatat tcgcttcaag caaaatccgt tatgtgcttc ggtccatttt ggccagtata 3239041 tttattggtt ttggcattac agccgcaagc aaaacaggca gctatttctt tatggctgat 3239101 tctccgtttg cctttccggc agccgctgtc actttcgggg ccgctattct gatgattgct 3239161 tacggaggcg gagatttatt taccggcaac accttttatt tcacctatac cgcgctccgg 3239221 aaaaaaatca gctggcgcga caccctatac ttgtggatgt caagctatgc cggcaattta 3239281 atcggcgcca ttctgtttgc catcctgatc agcgcgacgg gactttttga ggagccttct 3239341 gttcattcct ttttgattca tttggcagag cacaaaatgg agccgccggc ttccgaattg 3239401 tttttcagag gaatgctgtg caattggctt gtgtgcctcg cctttttcat tccaatgtct 3239461 ctcaaagggg aaggagcaaa gctttttacc atgatgcttt tcgttttctg cttctttatt 3239521 tccggctttg aacacagcat tgccaatatg tgcacattcg ccatctcgct tttgatcgag 3239581 caccctgata cagtgacact gatgggagca gtcagaaact taatccccgt tacgctcggc 3239641 aatctgaccg cgggaatagt tatgatgggc tggatgtact acacactgaa tcctgatcaa 3239701 taaaaaaact tccagagatc actccctgca agtcaaagcg gttattccga gagatcttga 3239761 agacgctgga catgcagcgt gatatagccg gcctcggatt ccggcaaatg taattgatat 3239821 tcatttttca aaaactccgc cagctccagc gcacattgat aggcgaatga atactttttt 3239881 tggatgaaat aaagcatctc ctcgtccata cgatggagcg cttcatttga ttccaaccgg 3239941 ctgaccgcgt atcgcaaatg cgtgacaagg cgttgatagg aaatgctgtt ttcatccacc 3240001 tttcgattaa agtattgttt tattttctct atcatttctt tgatcatggt cgtatgcttc 3240061 agcgctgaat acatgctctc cgcatccatc ttcgccgtat ggatgtgaag ggcaatataa 3240121 cccgcttcat cttcaggcag agacacgccc aatgtctctt ttacatgtcc gatcgcccac 3240181 aggccgatct catattcttt tttatagagc gcctttatct catgcagcaa tttattctgc 3240241 acaagcagcc cattttgaat cctttcgatc gcaaaggaca aatggtcgga aagcgcgata 3240301 tgaatgtgat cgctcagcgg cgccgcgagc tctccttccg catagctgat gatatcctca 3240361 gctatttcta tatgctcctc cggcagtgtt tgcaggattt gtttgaactt ttcattctcg 3240421 tcgcgcacga caaagatctt ttccacttta ttcataggga tgagatcatt tttctttttt 3240481 tgaaaagcga ttcccggtcc catcacgatt ttttcctgat catcctcttt tattaaagcc 3240541 gcattgttgt ttaatacttt atagattttc aagaggttat ctctcccgcc aatttgcttt 3240601 tgactgggat tttacctcct tttgaccgcc atgtaaagat gcgggcccgc tctctcctgc 3240661 tttggcgatt ccttgaaggc ttgcaaacat cttcttttat aaagcgcggc ggctttcgct 3240721 ttctgctttt cttcctcatt cacagccatc cgccattcat aaaacgaaac gagtcctgcg 3240781 gcctgcacag ccgcctttct ttggtatgta cgctgagccg aatagaccgc ggcagccgca 3240841 gtttttctgt ccggcgtcac ccagttcatc aaaaagacca tccacacccg taaagataca 3240901 agcaaacgtt tcatagaaaa acatccctcc gcttcttttt ggcaggcagc ctttttagca 3240961 gcccgttttc tcagccgcag cccgcaagaa aagacggccg atttcttttc tcgcaaacta 3241021 gcggctctag caaaactcat gactctatga tagaccgtgg aaagagaatt ctttgtcaca 3241081 atatgagtga aaaaaccaac tagtttttag aagttttgtt gaaagctgaa agaattgaaa 3241141 tgaaaattgg agaaccgctt tgaaaacttt atacacaagt tatcccaaag ataagaacaa 3241201 cttaatcaca agagatatcc acatgtccac aaactctatc tatattttgt atacgaacgt 3241261 atattcctaa ctatatatat acacaggttt attcacttat acacagggtt ctgtgtataa 3241321 ctccttcgtt atacacaaac aaaatccaat aaatggtcca aatgacacaa ggattttttt 3241381 gaattttcaa gaaatatata ctagatcttt cacatttttt ctaaatacaa agggggaaac 3241441 acattgaaaa aggggatcag tcagcaaacg cctcctgcaa taagcgatac gatcggagct 3241501 tatcttcaaa atgatgcgtg atggtcacca ccatgatttc ctctgtttca tacgcgttac 3241561 tcaaagctaa cagccgctcc ttaacctgtt ctttcgtacc aacaatcatt cgatttcgat 3241621 tatcagcaat tcgtctctgt tcataaggag aatacgtatt tttccgaaca gcttcatacg 3241681 aaggaactcc ctctaaagga ataccctgct ctcccgccaa aagtgtaaaa tcaagcacag 3241741 ccccaagctc ctctgccttc tcctccgtgt cagcacaaag aacaaaaaca gcaactgccg 3241801 ctcgaggcgt atctcctaac acagacggtt tgaatcgcct cttatactgt ctgacagtac 3241861 cctctccgcc ctctccattg ataaaatggg caaacatata gccagcgcca gattcagctg 3241921 cgagcagcgc gctttctcca gatgagccga gcagccacac atccggagcc gttgaaatat 3241981 gcggcgcagc ggtcagattc ggaaaacggt gtttgtcatc cgccaaatca tgcaaataca 3242041 tggtcagctc cttaatttgc tgcggatact gatcagcatt gcgcttacca ccgtcattca 3242101 gcgcccatga tgcaatcggc attccccccg gtgctctgcc aagccccagg tcaattcttc 3242161 ctggtgtcag cccctccaga acacgaaagt tttcagctac tttataagca ctgtaatgcg 3242221 gcagcatgac tcctcctgat ccaacacgaa ttcgctttgt tttcgctgct atatgactga 3242281 ttagcacctc aggactggac cctgccagcc gttttgaaaa gtgatgctca gaaacccaaa 3242341 atctcttata tccaaggtcc tcagcagctt gggcaagcgc aacggtttgc tgtaaggccg 3242401 tttctgcatt gctgccctct gatactggag attgatctaa tatacttaat gaaaccatcc 3242461 ctaccacctc atcctcatcg tatcactgat cccctatttt ttctccaaag ccgctcacac 3242521 tgcttatcag tgtcccctat cattcgccat ttatttgtga aagcatgtcc ctatttgtcg 3242581 gaatatgtta cacgtgaaac ataaaaaccc ctccagacgg agaggtttgc tttagttttt 3242641 attaaagccc ttttctttca cgtagtcatt taaatacgta cgcggctttt gcttcataaa 3242701 gttcagtatt tgatcggacc acgtttcttc ccgcttcccg tttgttcttt ctctatagta 3242761 atcagaaatg gttttgtcat acgtattcat agtatgacgg aaatcgtctg tgttcacatt 3242821 atacgtattt tcatgataaa cggcctgctt tggcaatctc ggttttttgc cggaaaggtt 3242881 cgcaggatgg cctactgcca gtccgaaaag cgggagcaca tggtcaggcg tttgcagcac 3242941 ctctgtcacc ttgtccaatt cattccgaat gccgccgata tagcaaatgc caagccccat 3243001 ggattcagcg gcaatgctca tattttgcgc tgccagcgcc gcatcaatca agctaaccat 3243061 aaacatttct gtattctcga gcagctcaga aatatgttca cctttttcct cagccagttg 3243121 ttgatggcgg tacaaatccg cacaaaatac aaaaaagtgt ccgttcttct caacgtaagg 3243181 ctgattccca gcaagcacgg acagctcacg ttttttctca ggatcagaaa ccccgataat 3243241 cgaatatgcc tgcacatagc tggatgtaga cgcagcctgc gcacttttca ctaatgtatc 3243301 aatttcttca gctgtcaaaa gctgatcagt aaaagaccgg attgaccgat gattcaaaat 3243361 ggtttcgatt gtgttattca tcacaaaaac ctccttatca ctttttatca tatccgaaaa 3243421 aaagtgatct caaaagtgaa atgctctgca caaaaaaaga cagcctctgt aaaggctgtc 3243481 tgcatatcaa gaattaaaaa gataacttct gtatttcgtc agctgcacac ttgcattata 3243541 tacaatccca aatccgatta acgtggaaag tgtcgagctt cccccatagc tgacaaacag 3243601 cagcggaatc ccggtaacag gcataatgcc aatgttcatt ccgatattct ggaatgtgtg 3243661 gatcacaatt aacgccgtat agccaacgca aaagaaagaa gcgaaacggt taaacggatg 3243721 tattttgtct atcagaacaa caagcctgta gattaaaaag aagaacatga tgacaacaat 3243781 tgcacagcct ataaagccaa atgactcacc tattatagaa aagataaagt cagtcgtact 3243841 ctctggaaca taaaccttca aattagaaat accattacct aaaataccac cagatcctat 3243901 tgccatgatg gcctggtcaa cttgccagct gtcatttgaa tcttcctgtg tctcatttga 3243961 agcagacacc caagaagtga cccgcttaat ttgataatcc tgtattccaa ctgatttagc 3244021 aacgtcagga aagtttatca ttactaataa aattaatgaa atgagtaaga tacctgaacc 3244081 agctatgatc gcaatcaatt tccaatttat ccctgacata aaaaccatta caagaacgat 3244141 aaacatacat attcccgcag tcccagcatc ctgcatcagg ataagaccta caggaataac 3244201 tgcgacaccc gcaatcttta ataacaagtg gatatcatcc ctaagcgtcc gaactccttt 3244261 aggatttgct tttccaataa ctgaagcaag catcataatc aaaccaacct tcataaactc 3244321 tgacggctgt attgttattc taccgatcct aaaccaactt tttgcccctt taataacagg 3244381 tgcaatagac tcgggactga ttttaagaat aatcaaagat aaaataccaa tgataaaaat 3244441 atataaactt aacttttcaa gctgttctaa atcaaagtac aaaagaactg taatggctac 3244501 agcccccaaa agataaaaca caatttgctg aatccaatcc gtgttcccat actgcccaaa 3244561 ctgaccggca gcatatattg atactacgct tataataaaa aacacaccaa atataaaaat 3244621 caaatccccc tggtaaaagg ggctttgctg tttcttatat cgactcattc tatcccgcct 3244681 tacattttca tcggaaaatc actaatgttt attatacatg aaccacgttc aagatgacac 3244741 gtgaagctcg cttcctttta tgttttttca gcatttgcgg cgctttttca gctacacgaa 3244801 atatgacgta tcataaaccg aaatgtttcg attgacacaa aacttttcaa atgaaaaaaa 3244861 cgccatacca atagaatttg ttaaaaaacg aatgcgataa tgtgttatgt tcccaaataa 3244921 tgtgatacct catatagaaa tagctaaaaa ttcagagccc catgcccata cattctccta 3244981 gcacattaaa cgaaaaaata agacgataga tccagtccat ttctgcaaaa acacgtatca 3245041 atttctggaa aacatggtat aataattgta acagaatgtt caaaaaacaa tcacaaaaca 3245101 gacacaactc agttcctcta tttcattttt gtaaacgtta tcacaaaatg aaaggagacg 3245161 ggtatgatgg acatgttttt tgcttactta ttggttgcca gcgcaacgcc tctctttatt 3245221 tggcttgata acaaaaaagt cgcactctca gctattccgc caatcatttt aatgtgggta 3245281 ttcttcttct tttacgcaac agaaagcctt tctccacttg gacacactct catgattatc 3245341 ttgtttgccg ttaacgtcat tgtcgctcat atcgccgcat ttatcattta cggccttccg 3245401 tatcttcgca gaaagcgaag cagctgaaga cagcaaaaaa ccctcttcca ctgaagaggg 3245461 ttttttgtat tattcgttat ggcctgaatg ctctgagtgt tcagcgcctc caggaggatt 3245521 tccgtccata tggtcaccat ggtgatagtg agccgcgaaa atccagatgg atccaagtac 3245581 gataacgatc gcgccaaaga atccgaacag cgtgtttccg acttggatcg tgccgttttc 3245641 gctctctgtc atatgcatga acatgagaag ctgcagcgcc gcctgaatga aggcgaagcc 3245701 gaagataatc caaagttttg ctgatgagct caggtcagta tacactgcaa cccatagagc 3245761 cagcagggtc aaaacgatag acaggataaa acctacaatg tgtttccatg gaaagtgact 3245821 gtgttcagca gatttgtttg ccattttaca gaccccccaa tcccatgaga tagacacctg 3245881 taaagatgaa aatccataca acatctaaga agtgccagta caagcttgag ataaagattt 3245941 tagatgaagt ttgcggagtt aagccgcgtt tcttcaactg aatcagaatt cctgtgatcc 3246001 agaaaatccc gattgttacg tgagttccgt gagttccaag taaaacaaag aatccagacc 3246061 agaacgcact tgtactgaga gccgctcctt catgtacata gtgaacaaac tcgttgatct 3246121 cgcatccgac gaagccggca ccgagaagaa gagtgataat tgtccaaatg actacgcctt 3246181 ttaaacttcc gcggcgcatt tcatgaacag cgatcccgca ggtaaagctg ctgatcagca 3246241 gcaagaacgt cataatcatt accagattga cttcaaatag ttcgtctggc aagacacctc 3246301 cagctgttct gtttttaaga acgaagaagg ttgcaaatag tgttgagaac aacacaattt 3246361 ctgcccctaa aaagatccaa aacccgagaa tattaagtct gccggtttca gattgatatt 3246421 ccataggcgc gttagaattg ccgtgttctg catgttccat aactcacgcc tccttattcg 3246481 gaaatctttc tttccgtctc ttttatttca tcaacactaa tgtagtagcc gttgtcgtat 3246541 tcgaatgaac gcagaaccat gcagagcagg actccgatca atccgactac gcccatccag 3246601 taccattcaa agacaagtcc aaagcctgcg agaccgaagg caacagacat aaagaacggt 3246661 ctgcctgagt tgcttggcat atggattttc ttgaatttgc tttcagggta taattcagtt 3246721 ttttcttctt tcatatgcag gaatgcatct tgagatttga cttcaggaag caccgcaaag 3246781 ttgtaatgcg gcggaatcgc agaagaagtc gcccaatcaa gcgtacgtcc cacaccccat 3246841 gaatctccgc tgatttcacg agtagagtaa cggaagctgt agtagatgtt atagcaaagg 3246901 attaagaatc ctacacccat catgaaagct ccgactgttg agataaagtt caatgttgtc 3246961 cagccgtcat tcggtccgta tgtgtaaata cggcgcggca tgccttgaag ccccaagaaa 3247021 tattgcggga agaaacaaat attgaacccg atcataaaga tccagaagaa ccattttccg 3247081 attctttcgt tcagcttgtg gccgaacatt tttggatacc agaaaataaa tccggcgaaa 3247141 caagcaaata cagtacccgc aatcagcaca tagtggaagt gagatacaag gaagtacgta 3247201 ttatggtatt gataatccgc tgctgccatc gcaagcataa cccctgtaac cccgccgata 3247261 acgaagttag gaatgaacgc aagcgcccac agcataggtg ttgtaaagct gattcggcct 3247321 ttatacattg taaagagcca gttaaagatt ttaaccccgg ttgggattga gattgccatt 3247381 gtcgtaattg agaagaatga gttaacggac gcactgttcc ccattgtgaa gaagtggtga 3247441 gtccaaacta agaaactcaa tacagagatg gcgataatag aaccaaccat cgctttgtaa 3247501 ccaaacaatt gttttcttgc aaagcttgag atgatttctg agaaaatacc aaacgccgga 3247561 agaataacga tatatacttc aggatgtccc caaatccaga acaagttagc ccaaagcatc 3247621 ggcataccgc ctgcttccaa tgtgaaaaag tgagcgccga acaaacgatc aaatgataaa 3247681 agtgctaatg ctactgtaag tacagggaac gcaaacacga taataaccat tgtgatcagt 3247741 gttgtccatg tgaacatcgg catacgcatt aatgtcatgc cttttgttct catttttaag 3247801 attgttacca taaagttgat ccctgtcatc agggtaccga taccggcaat ctgaagtccg 3247861 aggaggtagt agttctcacc cggcccaggg ctcatgtcgt tacttgcaag cggcatataa 3247921 ctcgtccagc ctgcgttcgg agaacctccg ataacgaaag aaatattgaa aagcatcgcc 3247981 cctacaaaga acgtccagaa gctcaggttg ttcaagtaag ggaacgcaac gtcgcgggca 3248041 ccgatttgaa gaggcacaac aacgttgata agaccgatta agaacggcat cgccatgaag 3248101 atgatcatga ttgtaccgtg agttgtaaaa atttcattat agtggtttga gtctaaaaaa 3248161 ctgttattcg gaagcgctag ctgggcacgc atcatcagac cgtcgacacc gccacggaat 3248221 aacataatta cagcagatat aatatacatg attccgagtt ttttatggtc aacagtagtt 3248281 atccattcag accacagcca tttccacttt ttgaagtaag tcagaacaaa aataatggca 3248341 atggttgaaa gcgcaatgga aacttgtgcg cccagaatta atgggtcacc agttacgaaa 3248401 aattcgtccc atttgaattt catgcaggct tcctcctttc ctgatcaata tcattcttct 3248461 gtatcatcag acttcttaaa ttcgtttttc tttacgtttt caaacggatc tgttttagaa 3248521 tgcggtgaaa cggcttgata gccaaggcgt ttgcgcgcct ccatcgcgta ctcagcgtct 3248581 tgtccgtgat caacgtattt caagtgagta gaagagaacg ttaattcgtc cacattttca 3248641 ggaagcatca attcatcata cttctctttt gtcagcttag gagcctcgtt ctgagtcttt 3248701 ttcacccagc tgttaaagtc tttttctgtg actgcattca catcaaactc ttggtctgca 3248761 aaatgttcac ctgtgaagtt cgcgttgcgg ccttcgtaag tacccacttt gtcagcctgt 3248821 aagtattgat ccatcagcat tcctgccatc gcatattttt gccctccaag ctgaggaatc 3248881 catagcgaag ccattgaatc tgcagatgag attttgaaca agatcgggcg gtcgacagga 3248941 atgtttaagt agttgaccgt ttcaatatcc tgttcagggt agctaaatac ccatttccag 3249001 tctaccgaag tagcataaac aacaagaggc tctttgtctt ttgttgcttc aggagctttt 3249061 tctaacgaat atatcgtctg tactgttggc acagaaagtg caatgacgat taaaattggg 3249121 atcactgtcc agactacttc taaaaacgtg ttaccgtgaa tttctgggtt ataagatcca 3249181 ttatctttgc ctttacggtc gcggtatttt actaaaataa tggtaaatag aacaaagacg 3249241 accccgacga taaacagcat aaatccgata gataacagga ttaaatcact ttgctgttca 3249301 gctacaggtc ctttcggatc tagtactgaa gcattgctgc atcccccaag gacgaaaacc 3249361 acagttaaca gcgctaatac aagcaacggt tttaatgctc tgaacaagaa gatcaccatc 3249421 cttcctattg atgtaataaa tctgaagtgc atacttcctc aaaatctttt ctctactttg 3249481 ttatgctatc aaaaacttca cttattagct ttattttttt ataaacttca tcccattttc 3249541 gcttaaatgt cataaaatcg acaaaaattg ctccaacttt attcacatct atcgcttaag 3249601 atgaaaagtt tctagttatt tccgcatata aagtaaagaa agatgatgaa gaactaattc 3249661 tgacaaatta aggtttacca caataaaaaa cttaggtcaa tcaaaaattt cattttgtta 3249721 aactttctag ataggaatta ttttttcctc gtctagcatc ttttcacacg gttaccattt 3249781 taacgcatca aatattgaaa gaaaaggcgc aatgaagagc caatatgctc tgaattgtcc 3249841 gtattttttt atgagagcat ccagttgttt atcttataca aaaaagagga atgatataag 3249901 caaataaata aaaaatagga tgtgttgcat gatgagtttt cttatttcac ttatcgtcgc 3249961 tattattatc ggatggcttg gaagcctgtt tgtaaaagga gatatgcccg gaggaattat 3250021 cgggtctatg atcgcaggtc ttataggcgc ctggatcgga cacgggctgc ttggaacatg 3250081 ggggccgcac ctagccggat ttgccattat tccagcggta atcggcgcag ccattgttgt 3250141 ctttctagta agcctgttaa ccagaaaaag aggataaaag cagcagcacc cgaagcgtca 3250201 gcgctttggg tgtttgtttt gccataaaaa tcgaaaaagc ctcaacccta gcggttgagg 3250261 cttttgactg gtttggcgcc caactgatcg atgaaccttc tgaaggcctg ttttccctct 3250321 gctgtctgct taaatacacc ggcgtgttca aggatgcgcg cgaatacatg tcccagctct 3250381 tcttttatga ctagatctac gttctctttt gttatggttc ttttttccat cgtccgaaga 3250441 gcccactcac tatgctttgc agtgagcgga ttttgttcta aggctgtttt cggatcagca 3250501 gaacatagcg ccgctgccgt ttctttcatt tcctcctgta agcggccagg caatatcgcc 3250561 aatcccatga cctcaatcag gccgatattt tcttttttaa tatggtggac ttcttgatga 3250621 ggatgaaata ttcctaatgg atgctcctca tccgtccggt tgttcctcag tacgatatcg 3250681 agttcgtaca agtctcccct gcgccgcgca atcggtgtga ccgtattatg gggcgtatcg 3250741 cctgtatagg cggcaatgcc ggctttttca tcggaatacg tctgccacgt gcggaagata 3250801 tggtcagcag cttcggcgac atgacccggt tcgtctcctt ggagcctgag cacagacatc 3250861 ggccacttca ctaagcccag cgacacgccg ggataatcat ttaattcata aacgtcttcc 3250921 gcttctgcac gtgccattgg aaaatcatgc gcgccgcctt ggaaatgatc atggcttagg 3250981 atgctgccgc cgacaatcgg cagatccgcg tttgaaccga taaaataatg cggatattgg 3251041 ccaagaaatg acagcagcct ttcaaatgtt tttttgctga tctccatcgg ttcatgttca 3251101 ccttttaaga caatgcagtg ctccggataa tagacatatg gcgagaattg caggaaccat 3251161 tgttcgtcct caaggatgac cggaatgatt ctgtgatttt gccgggctgg atgattcacg 3251221 cttccctcga agccgacatt ttctttacac agcaaacaca tcggataatt tgtctgttcc 3251281 tgctcttttg cagccgcaat cgctttcggg tccttttcag gctttgatag gttaatggtc 3251341 atttccagct cgccatattc ggtcggcacc gtccaatgaa catttttggc gattctgtca 3251401 gtccgtatat aatagacatc ctctgaatat tgatagaatt cctttgtcgc ctgttttggg 3251461 ccgtataatg cttttgtctc ttcaaatttg cgaatgacct cggacggggc aggcacaaaa 3251521 cagcccatca gctttgcgct gagcaggtca cggtacgtat ctgtatccgc ttccattcgg 3251581 ccggtttcgg cagcccattt atagatggga gctagcaagt ccggcaggct ttgtgactgc 3251641 ttgatgctgg tgctggagtt cggctcggga tgtgtgatgc ccagcgcttc ataaagacgg 3251701 tttctcgtat attcccgatc ccagatcgaa atcaattttc gttccaggcc atactcaagc 3251761 agctgttcca gatgttcaat aatactcata tgtcactccc cctttagttc tctcgctccc 3251821 tctccgatat ccgcgacata aaagtccgct cggagccctg ttttttcttg atatctgtct 3251881 ccaaccttct gaataaaatc atcaacgaac tcatctttta caatgctgat ggtgcagccg 3251941 ccaaagcctg ctcccgtcat tcttgatcca attacacctt cgtgatccca tgccgcaaac 3252001 acaagctcat caagttcagg gcatgttact tcatagtcat ccttcaatga aaggtgggat 3252061 tccttcatta actgcccgat ttcatctata ttgttctctt tgaacatatg ggccgtctta 3252121 atagcacgat gattttcgta tacagcgtgc tttgcccggc gtctgttcgt ttcattttgg 3252181 atcaggctgg aatgcgcatc gaaatcagaa ggcttgatgt cgcccagtgc ggcaatatcg 3252241 aggccttttt tcagatcaag caatgcatca ttgcattctt ggcgtctcgt attatagctg 3252301 gagtcagcca atgtcctttt tttgttcgtg ttcgcgatga ccagcgcgag gcctgagaca 3252361 ttgagtttgc tatattcata gtcaagcgtg tcacagttca gcagcatcgc atgatgtttt 3252421 ttccccattc caattgcaaa ttggtccata attccgcaat tgacgccgat aaaatggttt 3252481 tccgcatgct gcgccatttt cacaagctca agcgcatcta cttcaggatg aaaataactt 3252541 tggagcacga cccccatcag cagttcaata gaagcggaag acgacagtcc cgccccgttt 3252601 ggaatattcc ctgaaaatac aatgtcaaag ccatggggaa ctgcatatcc cctctgttga 3252661 aattcataaa tcacgccttt tgggtagttc gcccagtcgt cttctttttg atagcgaatg 3252721 tcgtcaaggc tgcattcctt gatgcctgcg tttctaaagt tatctgaata catccggaca 3252781 agcccgtcgt ttctttctgc aacagcagca tatgtaccca ttgtcagcgc gcacggaaag 3252841 acatgcccgc cgttatagtc tgtatgttct ccaatcagat tcactcttcc aggtgcgaaa 3252901 aaaaaccgta acccctcttt ttctccgaat acacttgcaa atatcccctt tagctcttcc 3252961 cgcatgtgca atcacctttc tggtttttat tttttattcc ccttatttct tcatagaaaa 3253021 cggcagatca tatgctgcag tcctctcata ccccttcttc ttttgttttt ttaaagacga 3253081 gccatttgct cgcaacatag ttgacgacaa caatgaccgc gttgtcgagt attttggcca 3253141 aggtttcatt tgtattgaac tggccgacaa gaatgatcat catgcctaaa tctatgccga 3253201 gagacaggac ccgaacgctg aaaaaagcag tgagctcttt cagcaggctc tgcagatcat 3253261 gtgttttttg ctgaaacaca tataatttat ttgttatgta agcaaacagc acggacaaaa 3253321 tccaagcggc aacagtggcg gctttgtaat ccacattcat gatctctacc aatatataaa 3253381 agctggcgat attcacaatg gttgtgaaaa cccccataat gatatacata attatttctc 3253441 tatacttcac tgatgttcct cgctttctga aaaacttttc aaaattcttg gcctctcgtg 3253501 ctctctgtct aaagtaaaaa ataccgagag tgcgtctaaa aagctgcgga aggtggctgg 3253561 ctggcccaat acatatgatt gtttgatgat tccgtcgagg actgcacata ttattttagc 3253621 cgtatattca ggatcaatac aggcgtcaat cagctttctc tccttcagcc acttaatata 3253681 taacacattt tcttccaccc acaattcgta cagccggaca taggccttgc atttctttaa 3253741 gactttatat gtcggcatgt tcatggcaaa cgaggtgatg tcccacgacg gcttatttat 3253801 gtaataggaa taaagcagtt ctgcagcgtg ttttgcagcc tcgtccaatg tcagcgattt 3253861 cactgactcc cgctccattt gatcaagata ccctataatg atcttttttt tcatctgacg 3253921 tttttcgaga aggtacagca gaaaatcgtc cttgctgaca aaatgaacat aaaatgctcc 3253981 tttgctgtac ccggcggctc tgctgatatc ttctacagaa accggatcat acgctcggtc 3254041 aatcaacaaa ttcacgccag cgtctataaa actttcaaat gttgcttctc ttttaatttg 3254101 aaatttgttt tttttcatat ttttctcctg gcggtaatga ttacccttat cttacaccgg 3254161 atcaatcttt agcggtattt atttctttaa acggttatgc tattcggttt cccaggggtc 3254221 atttttaata ggctaaatga tttattttca tttacatact atccagtcag tatttaattg 3254281 tttattatta taaataaggt ccattggtta tattagtcat ttttttaggg aataggtagg 3254341 tggtttttcc ttcagtttgt gaacaccgag caactatgtg tgaaatttgt tgtactcgcc 3254401 tccatcatcg cgctggcttg tcttttattg cccgcatgtt gcaggaaaac attttataca 3254461 attggaggtt actatgaaaa ctcatgttaa aaaagatttg gacaaaggtt ggcatatgtt 3254521 aattcaagaa gctagatcca ttggattagg cattcatgat gtgaggcagt ttttagaatc 3254581 tgagacagca tcaagaaaga aaaaccacaa aaaaaccgtc cggcaagact agtccgaaca 3254641 ggcggatcta tttacctctg gcttttctat cacctgatct gagttttcac catatcctct 3254701 attcaaaagc aaatcgctgc gctgagcttg aggacaaacg gtgtgtcagc taactacgac 3254761 agacagccgg tgatgcgatc acctcttggc acatgcattg tcataaagag gtgatgcgaa 3254821 catgataacc gtgctctggt aaacagcagc tttgctgaga acaagctgca ttcggtgagg 3254881 ttttgaaagc aaactcgttt atacacggcc gagcttgaaa accttcgcct gtctttagac 3254941 cactgtgttc acctcttcac gacttccttc ttttttcatc ctccagctat tgtacaacgc 3255001 ataaatcgga ctttcagtac atacctattg gtgtaccttt ttgcttacgt ttagcgaata 3255061 aaaggaggaa agccatgtac aaagctgatt ataaacagat tgctgcaacg ccgtcttttc 3255121 aagctttttt aaagcagaaa cgcgctttta ttgttccttc tgcgattttc ttttttgttt 3255181 tttatttttc actccctgtt ttgacatctt atttcacctt tttgaatgca ccggccattg 3255241 gagctgtttc atgggcttgg ctgttcgcca tcgcccaatt cgctatgacc tggatactga 3255301 gtactgtgta ttcccggaga gccgcccatt tcgataagta tgtaagcgct ttaaaagagg 3255361 atctgaaggg tgaacagaca tgaatatgac tgctttttta ttatttttgg cgattgttgg 3255421 cctgacgctt attatcacgt attttgccgc gaagcggacg aaaacgacga gtgagtttta 3255481 tacggcgggc ggcgggctca ccggcgttca gaatggactg gcaattgccg gtgactacat 3255541 gtctgccgcc tcgtttctcg ggattgccgg aatgattgcg ttatatggat ttgatggctt 3255601 cttttacagc atcggttttc tggtggctta tctcgttgtc ttgtacatcg tggcggagcc 3255661 gcttcggaat cttggaaagt acacgatggc agacatgatt gccgctcgct ttaaagaaaa 3255721 gaaaatccgc ggtgtcgcgg ctctcaatac cattgccatc tctacttttt atatgatcgc 3255781 ccagctcgtg ggggcgggcg cgctgatcaa actgcttcta gggctggatt ataccgcggc 3255841 tgtcctcatc gtcggagtgc tgatgaccat ttatgtcgtg tttggcggca tgatcgcgac 3255901 aagctgggtt caaattatta aagctgtttt gctgatggcc ggcacactcg tgatttcgat 3255961 tatcgtgttt tcgaaattcg gctttagcct taataccatg tttgaacaga tgaaaacggc 3256021 tactccgctt ggcgctgatt ttttgaaccc cggaaataaa tacaaggtgc cgcttgagac 3256081 cttgtcgtta aacttggcac tcgtgctggg aaccgccggg cttccgcata tattgatccg 3256141 gttttatacc gttaaggatg ccaagacggc ccgtacatcc gttgtgtcag cgacatggat 3256201 tatcggtgtg ttttacatta tgacggtatt tctcggcttt ggtgccgcgg catttgtcgg 3256261 ttttgacgcg attacggcgg ctgatcaagc gggaaatatg gcggctccgc ttttagcaaa 3256321 agcgctcgga ggagactttc tgttcgcgtt tgtatcagcc atcgcctttg ccaccatttt 3256381 ggctgtcgtg acagggttgg tgctgtctgc cgcctcagca tttgcccatg atatttacag 3256441 ccagatcatc agaaagggag aagcaactga aaaagaacaa atgaaagcgg ccagatgggc 3256501 ttctgtcgcc gtgtcagtgc tctcgattct ccttgcgatt tttgcacaat ccttaaatgt 3256561 ggcgttcctt gttgcactcg cgtttgcggt agccgccagc gcaaaccttc cgctgattgt 3256621 gtttacagtc ttctggaaac gattcaatgc ctcaggcgct ttatggggca gcctgacagg 3256681 cctgatcagc gcgcttgtgc tggtatcgat gagccctagt gtgtgggacc cggccggagg 3256741 tgctattttt accggtgatc cgctcattcc gctatctaat ccaggaatta tttccatccc 3256801 gctcggcttt ctcggcgcgt ggctcggaac ggtgctgtcg tctgataaaa caattgatga 3256861 agatacgttt gcagaaattc aggtgaaggc gcatactggc gtccatatgg aacaggaata 3256921 aaaaaagctc tctttatcga gagctttttc cttacttttt cttctgctcg tcagaaatcg 3256981 ctttttcaaa tacatccttg ccggcagcac ccggaattac agtgtcaccg ataataaagg 3257041 ttggaacggc tgtgatgtca gcctcttcat aggcgtgctt caaggcttgg cgctgcacgt 3257101 cctgatatgt tcttgtttcc agtgctgatt tgaatgatgc accgtctaat cccacttcct 3257161 cggcgagctt cgtcaagatg tcaatatcgc cgatattttg gtcctcctgg aaaaatgcct 3257221 gaaagacacg ggtgttgtat tcatgtcctt tattgtattc cttcgcaaaa tggaagcctt 3257281 caaacgcgag gtctgtatac ggatggggcg agacgtttgg aaaattgatc tcgactccta 3257341 atttctccgc cattggctga attgatgtct gccacatgta ctgtttagaa ggatcattga 3257401 ccggatcaag ctgaggagat gggcttgggc gcagttcaaa cggcatccac tcgacttcaa 3257461 catcctttcc ttttatcgct tcttcaaaag cggcttttcc aacaaaacaa aatgggcaga 3257521 cgtaatctga ataaacttta atgtgtactg tcatgataat ctcctttcat actaaattga 3257581 ttttaaactg taacaattaa agttacaact gttttttaat aaagaagccg atttaggctt 3257641 ctttcagatt gatgacaaaa tcctaaaaag ttttaggatt ttgtcatcct ttcagcgtga 3257701 ttgaaaaccc ttgaagtcta ggaaagccga gcattggagc ggagcgaatg ctctaattcg 3257761 tgagcaccaa cgcacaggct tgacaacgaa tgcgagggtt tgtcgacacg ctgaaagaag 3257821 cctgtaaagg cttcttttat gattccagca aacgctgggc aatatattct ccttttttgc 3257881 agccgcctgg gcatgcgtat aaagcagaac cgattgtttg tgtatattcg tttaacgcat 3257941 cctttgctga aagagccttc agcatcggga taaactgatt gtcgggattt ttttgaaaac 3258001 tgataaacag gagacctgca tccatatagc cggttttcgg atcaagtcct tctgtgtaag 3258061 agaaagctct tcgcaaaatt tgtttcccag tagatttcgc tagactgacg tgtgaattag 3258121 acggaatttg attcagcttc acgggatctg tttccttttt ctgcccaaaa ggcgcccccg 3258181 agctttttct gcggccgaag gtatcctctt ggtccttgag ggaagagcgg tcccatacct 3258241 caaggaacat tttgattttc cgaaaagcca tataggtgcc gcccgtcatc cagtcaggct 3258301 caccagactg aatccacacg atcgagttca tcaacgtgtc atccttcgtg ctctggttgc 3258361 ctgttccatc tttaaacccg aagaggttgc gcggtgtttc accatttttt ccaccgctta 3258421 aaaagccttt gttcacaaaa cggacctcac aagtgccgac cgcttgattt agcaggttac 3258481 gcagcgcgtg aaacgccact tgctcgtcgt ctgcacacac ttgaatgcag atgtccccgc 3258541 ctccctgctt ttcatccagg ttgtcattgg gcatcgctgg aagagcggct aggtgcttcg 3258601 gttttttgct tttcagtccg aagcggtcct ttccgtcttt ttcaaaaaag ccaggcccga 3258661 atccgaatgt gaccgttaag ttggaagggg ataaatcagc agactcacct gtatcctgcg 3258721 gcggcagata ctgatttctc tgctccgctg acattttctt gccagacgtc agcatctgtg 3258781 tgagacttgt ccagtttcta aataacgtaa tgatgtcgct tttgtctttt gctgttacat 3258841 ccagtgcagc aaaatagaca tacgtctgat gggcagttgt gattccggcc tgatgctttc 3258901 cgtaaaacgg aacaatctgc tcctcctctt tttcatcctt tttcgatggc ttagccgcag 3258961 tctgaacaag cggagcgaga ccgccgagac cgctggcacc gatcgcaacg gctgcccccg 3259021 ccatcgctcc ccattttaaa atgtcccgtc tgtgaatttg ttctggcttt ttctgttcat 3259081 cgctcatgat gttacaaaac tccttttata gcacattcgc aatcttcgac atggtttcag 3259141 aaagagtcgt cagcttagtg ctcagctctc tgatttgctt ttcacttaat ttatcataag 3259201 acgtatagga ctgatcattt gttttgtatt ttgccattaa aacttcaaat tcgctgaact 3259261 ccgtatccag tttttccgtc aagtcggagt gatcttttac aagcgcgctt ttcactgttt 3259321 gataaacggc ttcggagcct tccacatttg ccataaggtc aactaaatca attcgtgagt 3259381 agcgctcttc ttctcccgtg attttcgaaa ttccggcttc gttcagaagc tccatcgcgc 3259441 ctgcaacaat ttgttcaggt gttaatttca gtgattgaat tgaaccgtca agctctttta 3259501 catccttgag aagctggtca gctgttgcct tttccccgga aatatcttga tccttccaaa 3259561 tggccttctc aagcttatgg aagcctgtcc atttgtctcc ttcttcaaca tcgttttctc 3259621 gtgcgtcaat tttcggatca agatctccga ggctttcagc gatcggttcg attcgctcgt 3259681 aataaacacg cgctttcgca tataacgttt tggacttttc gatatcgccg gatttcacag 3259741 cacccgtaaa tgcttcagtc gctttgacaa gctggtcact ctgctctttg acatagcctt 3259801 tatactcatc cgctgctttt gccagctgat cgctagcctt tttgccgctc ttcttcgctt 3259861 ctgtcaggtc ttctaaggat gctttcaatg actcggattc tgtcttgatt tttcctgcat 3259921 ccggtttgtc tttttgcgct tctgtgtaga ttggctgaag atgcttttcg atttctgtat 3259981 attcgaatgg atagtcgctg cgaatatcgt tttcaaagga aagccagtag ctgtttaact 3260041 ctttcccctt cttttcaatc tctttttggt ctcctttttc cactgagtca ttcagcttag 3260101 aaatgatggt ttccatttta tttacggatg cggtgatttc tttagtgacc ccgctttttt 3260161 cagatgaagc tttttctttg gttgaagatg tgtcattggc tccgcagcct gcgcacagcg 3260221 caaggatgca tccggctgat acagcgattt ttgtgaaatt cattttgtca gttcctttcc 3260281 gtttgtaaaa tgttttgccg cttctgaaac aagcgcaatc agtaaaaaga gtaaaatcaa 3260341 catttgcgga atcgtgctgt acacagacgg ataaattcct agcaccgata cagacggcag 3260401 ccagctttct gcatcagacg gaagaatgcc cgccagttga aggctgtgaa cgccggttcc 3260461 gagaaatttc acgcacatat acaggacaac cgccattgat agaagaaaaa acggcttcaa 3260521 tggaatgcgc attccgagct tgatcatcag aacaccgacg atgacgagaa cgataagccc 3260581 tgcggcagtt ccgccgatca gttcagtgag cgggagcttc ccgacaagcc cgatgaaaaa 3260641 gatgaccgtt tcgagacctt ctcttacaac tgccagaaat gcaatgagcg caaaggaaag 3260701 caggcttcgt ttttttagtg cctgtgactt ctggatattg attttttctc tccatttatc 3260761 cattgaggcg tttctgtgca gccacacccc gacatacaaa agcatgacag cggacagtac 3260821 gccggtaacg ccgccaagca agaaattgtt ttctccgaat acactggagg agaacagaac 3260881 cgtgacaccg atgccggctg ctaaggaaac agccatgccg gcggacgccc cgccccagat 3260941 ccatgtcgag gaacgcgtaa cccgcgcttt ttttgtcatg gttaatagcg ctccgatgac 3261001 aaggagggcc tccattcctt cacgaaccgg gatcagcgcc gcatcccacc agctgtagct 3261061 gcttgaagcg atcggctcga gcaattgaat catttcgtca atttgctttg ataccttttc 3261121 aggatggctg ccgatctccg ccttcatcag cgccagattt tcctccgatg tcgtataggc 3261181 ttctttcgat tgggacacga catctccctc aacagcgagc caggatgtaa ctaaattgtc 3261241 gattgcggat gacgcttcat ccaattgttt tttttctatg aactgttttg tgtctttcaa 3261301 gctttgtata taggctgtta aggacgccct tgattgacct gaggatgtct ttttcagcac 3261361 gacagcctgc tgataggttt ctaaatgaga cgcaagctct tcaagctgtg ttttgagctt 3261421 acgtgcgtct tgattgataa aagaaagaga aatcatcgcg atattcgcgt ccatttcact 3261481 gtgagaagaa aggttttctt tcttaataga aggttcttct tttttccact tcgccttgaa 3261541 ggtgtcaaac gtttgttgtg ccgaatccat atccccgtct tttacggatt tgatcatttg 3261601 cttgtttaat tgaattaatg cggcgatcgg atcatcttcc gcatgtgccg cagaaccgaa 3261661 aaccatcaac aagctgaata gaataagtgc cagcccccga gccatcatgt tcctcctata 3261721 attgaaaatg attatcattg tataacataa tcatagccag ttcctgtcct ttgtcaatta 3261781 aaatttgaag gtctgaaaac cttgatggac agcaaaaaag ctgtcctttt acagaacagc 3261841 cctttgaagg aaaatgaacg attatcttcc tgttttatac gtttgaattt cctcacgaaa 3261901 cttgcgtgca gcactctcag gatcctccgc ctgactgatg gcgctgatca tactgacgcc 3261961 atcggccccc gcttggataa caggtgcggc attatctatt gtgattccgc cgatgccgac 3262021 aattggaatg ctgatgcctt ggcggcgcac tgcttcgata agagatacac cctgtaccgc 3262081 tctcgtatct tttttcgttt cagtcggata gatcggccca agcccgacat aatccgctcc 3262141 gtcttcttcg gcttgcttca cctcagacat cgtatgggca gaaacgccga gaatcatatc 3262201 acctatggca gctcttacct ctttcgcatt tgcgtcttcc tggccgatgt ggataccatc 3262261 agctttcaga ttcagagcca attccacatc atcattgaca atgaacggaa caccagcttc 3262321 acggcaagct gcctgcgctt tttcagcaaa tttaatccga gcctctcctg tcagcgcatc 3262381 cccgcctttt tcacggaact ggtacagggt ggcaccgcct tttaacgctt tttgtacaac 3262441 tgtaacagga tcggctttcg tattgtttga ccccataatg aagtatacag ataataactc 3262501 tttcatcatt tcccgagaaa tacgagtcat gagacagtca ccctttctat agtcgcccat 3262561 tcttggacgt cttgttcagt aacagttgaa agcttgttca gcaattcaat ctgaaagctt 3262621 ccagggcctt tgtcagccgt ctgctgtgcg gcaagctgag cggcgacccc atacgaagaa 3262681 atggccgcaa tagcagcaaa caatggattt tcttccacag cgcaaaacgc accgacgacg 3262741 gaagtcagca ggcaaccggc gcctgtcact tttgtcagca gcttgtggcc gttatgaagg 3262801 gtgtatacat gtgacgtgtc ggctatgaca tcaacttcac cagttatcgc aatgaccgtg 3262861 tttagctttt gtgccgcctg ctgagccagc cggatgatgt cgcctccacc ttcacccgca 3262921 tcaacacctt tgatcagcca atcggtcacg ccgacggtat gggcaatttc cgccgcattt 3262981 cctctgattg cagcaaggcg cacctcacga atgatgtcac gtgccgattc agtgcggaac 3263041 ggtgttgctc cggcaccgac aggatcaaga atgacgggaa cgccatgttc attagctgat 3263101 tttcccgcga tgatcatcgc ttcgactgac tccttgctca gtgttccgat atttaaaacg 3263161 agtgcacccg caattttcgc catatcggcg acctcttctt ttgcgtacgc cataacgggc 3263221 gatgcgccga gcgcgagcag gccgtttgct gtgaaattcg ttacgacatt gttggttatg 3263281 ctatgcacca gtgggctatg ccggcggaca gccgtaagac attttgctgc tgattgtgca 3263341 tccatatttg catcatcctt tactatcttt tttcgggtcc cataaatacg atttcgtatg 3263401 ttcgagccaa gctctggcgg caaacgacaa gtacctgtcc tttctccaaa taatggcgag 3263461 gtgccaaggg atgaccggat cgacaagcgg aatgactttc actttttccg ggtcaaggcc 3263521 gcggcagatc cgttccggca aaagcccgat cccaaggttg gcggatacca tctcactaat 3263581 aaaatcccat tgtgatgttt cataaatgat atggggccgg aacccagcct tgatacattc 3263641 cgtcataatt cggttgtgca ggacaaaatc ctctctgaag aaaataaaag gctcgtcctt 3263701 caactcacgc agctgacatt ctttctcatc agccagccgg tgggaagggt gaacgacaag 3263761 cattaaggtt tcttttacga ttgtaaacga atgaaagata tcttcgtttg cgggaaggac 3263821 cacaacgccg atatcaagag agccgtcccc gacaccttct tggactttta tagaaccgtc 3263881 ttcgactagc tgaaaggtga cattcggata gttttcacgg aaatcgccga gcactctggg 3263941 gaaaaacccc gatccgatca tcggcggcag tccaatccgt acgtgccctt tcttgacttc 3264001 cataatatca tttaattctg acgtcaggtt ttgaaatgat ttaatgattt cctgcgcctg 3264061 cacatacatg ctatgaccgg catcagtcag ttccacctgc ctgccgtttc ggtaaaacag 3264121 ttcaattccg agctcttctt ctaaattttt gatcattttt gatatcgtcg gctgagaaac 3264181 ataaagggat tgggaagcct tcgtaaaact ttttaaacgg gcgacttcca agaaatatgt 3264241 taaatggcgg atatccatgc gcttcaccct ttctatagac aaaaggaata cttcttattc 3264301 ttaatatata ttttacctat agagagacct tatgtacaat aagtatataa gggaggcatc 3264361 aatatgaaaa aactgttgct aaccgttatt caaatcgctc tgttatttat atttgctcgg 3264421 ctgattaatt gggtgacagc ccttcttcat ataaatattc ccggcagtat aatagggatt 3264481 gtgattcttt tcacattatt gcactttaac attatcaagc ttgaatggat cgagcttggt 3264541 gcagcgtggc ttctcgggga gctgctttta ttttttatcc cgtctgccgt cggagtgatt 3264601 gaatacggag acattatgtc gaaatttggt gtcagcattc tgcttgttgt catcatcagc 3264661 acgtttgtcg tgatggtgtc tacaggaacg cttacacaac tcatcgcaaa gagaaaggag 3264721 aaaaagcata cgtgttcatc ggaattgtaa gtttgttttt aacggttttg gtgtatttag 3264781 gagcaaaaaa ggtatatcaa cgctttccgc gtgtttatac gtcgccgcta ttggtgacgc 3264841 ccgctgtatt agtcggtctg ctgctgctgg tgaatgtccc gtacgagtcc tataatctcg 3264901 gcggcggatt gctgaccgat atgctacagc cggccaccgt ggcattcgcg atcccgttat 3264961 ataaatattt ccctgtttta aagaaatacg cagtggaaat tattttgaat gtggccgtcg 3265021 gttcatgcat cgcgattatt tctaccgctc ttattgcgaa atggcttcac ctcggcaccg 3265081 gcttaattga cagcctcgtc ccaagatcag tgacaacgcc gatcgcgatg aacgtatctg 3265141 aaatgatcgg cggtatgcct gccgtcacag ccgtgtttgt gattttaacc gctttgctcg 3265201 gcacagtgat cggcccgatg gtcatccgtt atttccgcat tgataacgaa attgcgcggg 3265261 gcgtgctgct tggcacaagc gcgcacggag cgggaacgtc aaaggcattt gagctcagct 3265321 ctgtgtccgg cacgatttcc agcgtgtcga tgatcttagc tgcgattatg acgctttgcg 3265381 cggcgccgtt tttgctttca tttatgtaaa aaactgtcct ctcgagggca gtttttttta 3265441 tgtgcttccc cttattgaaa agctggcgaa ttccaatata atgtatttgt ggataccaaa 3265501 ggaggcaccc tgatgcacaa cttgcaggtg aggcggcatt atgccgcgtt aaaaggattt 3265561 tatttgtttg cttttctcgg tacgggcagc ataattccct tactcagtat gtatttaacg 3265621 aaggaacagc atttaagcgg atcacaggtc ggcttgatca tgtcactggg cccgattgtg 3265681 atgattttct ttcagccgtt ttggggcatg ctgagcgact atacgcaaaa aacgaaaggc 3265741 ctgctggcgg tttgcacatc aatcacaggc atcattggat tagcctatat tgcatttgac 3265801 agtttccctc tgtttatttt gattgcggcc tgttttgcag cctttcaaag cacgattatt 3265861 ccactttcgg acagcatttc actaaggtac acacaagaaa caaacggcaa ctacggcgga 3265921 atccgcctgt ttggttctct cggcttcggt gtcgcggtgt ttgccatggg acaggtgacg 3265981 aaccagctgt accccattca cgtgatcttt atctttggct gtgcctttct gtgcattgct 3266041 gccatattgg cttcacaagt gcccggccag cagaaaacaa caaaggtcaa tatccgcaaa 3266101 ggattccggg agcttatcag caacaaaact ttcctcatct ttatgatcat cacctttacg 3266161 acatttgctc caaacttagc gaacaatacg tatttcagtc tttttctgga caaaagcggc 3266221 gcgtcacttt ccgctatcgg cattttattt ttcatcggtg tcatttcaga aattccattt 3266281 atgagattcg cccaaacatt tatagataaa atggggctgc tcaacgtcat tatgctgtca 3266341 ggcggagtct cattattcag gtgggcgctc tatttcacgg cgccttcact atggatcatt 3266401 tatgcgacgg tctttcttca gggagtggcc atcggtttat ttatcccggc ggcgcttcaa 3266461 tatgtgaaaa agattacccc aagacacgtt gaagcgacgg cgctgaccat gtacgccgcc 3266521 attggcaacg ggttcggcaa ctggttctgc acatttgcag gcgggtacat ttttgactac 3266581 gtgtcgatct tcgcagtcta cttgcttttt ggcattctga gcatagcagg ctttggcctg 3266641 acattatatt taatgaaggc tgaaaaaaac aaacatacac ttcatcagcc ggctgttact 3266701 tttaaaccat aatgactata atgaacaaaa gaaaggatgt gcgttatgaa cgggcaagag 3266761 cgaaacagca tttcgaaagg gttgcaggtt gatattgtat tgaaagcaga tcaaaaaaca 3266821 ggaaaactga cgagagggac agtgaaggat attttgacga aatcaaactt tcatccgcat 3266881 ggcattaaag tccgtcttga agatggccgc atcggccgcg accagcagat cgtttctaca 3266941 taaaaaaaag ctgcccctga acagggcagc tttttcatta ttttttctgc agaaggacca 3267001 ctttcaggta gttgccttcc ggaaatgccg aaatcgtttt gaaatcctcc ggcagcgtaa 3267061 attcctcaat gatcgtgtag cgttcatttg tttctttaaa ggcggcatca ataaagcctt 3267121 tgaacttctt catgccaaag gcgctgctgt ttgtagaggc aacaatgaca cccttgtcag 3267181 cagtgatggc gatcgtttcc ttcagcaggt ttttataatc cttggccgcg ctgaaggtgc 3267241 gtttttttgt gcgcgcaaag gaaggcggat ctagaataat cagatcaaag cgcaaatcct 3267301 tttttgcagc atatgaaaaa tagttaaaaa cgtccatcac tttaatgtcg tgcgcttcgt 3267361 aatccagctt gttcacgctg aattgctcga tcgttttggc aagacttcga tttgccacgt 3267421 cgacgcttgt tgttttctcc gctccgccaa gcgccgccgc cacggagaat gcacccgtat 3267481 aagaaaacgt atttaaaacg gttttccctt ttgcatagcg gtctctgatc gccttgcgca 3267541 catgtctctg atccaaaaag atgcccgtca tggcgccttc attcagatcc accgcgtatt 3267601 gaatgccatt ctcttggatg atgatcggga actcgcccct tctccctttc acgaagtcat 3267661 catcttcaac gtattgtcca gccgtgtcga agcgtttctt ctcgtaaatc gctttataat 3267721 caagatccat ctcatccaat gcggaaatca gcatgtcttt aaaggtgtaa attcccttgc 3267781 tgtaccattg aatcagcagg tagccgtcat aatagtcgat ggtgacgccg ccgacaccgt 3267841 caccctcacc gttgaacagg cggaaagctg ttgtatcttg agcctcaaat agtttggcgc 3267901 gcgcttgggc cgcttttgtt aatttgctga gaaaaaatgc ttggtcaatc tgttcatgtt 3267961 tattgcgggt aagcgtccag ccaacccctt tgttttgcag gccgtaatag ccccgcgcga 3268021 gaaactcgcc gccgctctca gacacgatat caacgaggtc tccttctttc atgtgccccg 3268081 cactccctgc gagagcttct ttttcaataa ggggatagcc tttttttatt ttggcagcgt 3268141 gtgctttttt tagggtgagt agcttcatat atgtcgtcct ctttccgttt gctttctctt 3268201 atggtaccac aaaacgccaa gatgtctgca ttgacagaaa ggaaaggttt ttctacgata 3268261 gacaaaaaga gttacgagga ggagcagcat ggcaaaacga attgaccata caggcatcat 3268321 ggtaagagat attaacgcgt ccatcacatt ttatgaagag gtactaggca tgaaattgaa 3268381 ggatcgcatc actcacacga acggtgtaat cgagcttgct tttcttggct ttgaagacgg 3268441 cccggaaaca gaaattgaac tgattcaagg ctacagcagc gagcttcccg ctgaaggaaa 3268501 agtgcaccac attgccctgc tgacggatga catcgcggct gaatatacaa aagcggaaaa 3268561 aatgaacgca aaatttatcg acgaggagat cacaacactt ccaaacggat accgttattt 3268621 ctatatcgaa ggccctgacg gtgagtggat tgagttcttt cagcggtaaa aataaagaac 3268681 gtacattttg tgatgtacgt tcttttttat ctataccaac tgatatacgg ctatacagcc 3268741 atgaacagca taaaatgaac gttattacag ttatcaccac atatggcggg attgtgactg 3268801 ggcaggcagg caagacccaa tgatgcaaag ggagtattaa tgcctaaaaa acagggcatt 3268861 ttaactcttc ttttcgtgtt gggctcataa cggcgccttg gacaaccccc tattctcatg 3268921 ctccgtcgtc gacgcgggca tttttgtcat tttcagccgg tatttctcac ttttttcatt 3268981 ttgattgtca acttttcatt tgatacgatg aacaagccga cttttcttca gcaaaggagg 3269041 ttttaattgc ttgcataaag agattgcaaa agaattactg ctgctcgcag gaggaaaaaa 3269101 caatattatc agcatcagcc attgtacgac ccgtcttcgt tttgatgtaa aggacgagac 3269161 gaaaattgat atacatgcca ttgagaacct gcaaggtgtg cagggcacct ttttccgcta 3269221 tgggcttttc cagattatct tcggagcagg cgtcgtcaac aaaatatata aagaagtcgt 3269281 tcatgtatgg gagaccgcgc cttctgaaga gcctgtccac cagaaaaaag ccagccggaa 3269341 gctgaaccct gccgcagctt ttgcgaaaac actgtccgat atttttgtgc cgattattcc 3269401 ggcaataaca gcaagcggcc tgctcatggg gctgatcggc atgattaagg tgtttcattg 3269461 gttcgctgcc ggcagcccat ggattaaaat gctcgacctc gtgtccagca cagcctttat 3269521 tttactgccg attttagtcg gcttcagtgc tgcacggcaa tttggcagca acccatacct 3269581 aggggcagtg attgcagggc ttttgacgca tcctgatctg ctggacccgt ctatgctcgg 3269641 cagcaaaacc ccgtcttctt tagacatatg ggggcttcat atcccaatga tgggctatca 3269701 gggttccatg ataccgattc ttctttccgt ttttgtcatg agcaaaattg agaagctatt 3269761 aaaatcgatt gtgccgaagt cgcttgatgt cgtgatcatt ccctttatta cggtcatggt 3269821 gacagggtgc ctcgcgctga ttgtgatgaa tcccgccgcg tccatcatcg gccagatcat 3269881 gacacaatcg atcgtctata tttatgatca cgccggcatt gctgccggag ctcttttcgg 3269941 cggcatctac tccaccatcg tcctatctgg attgcatcat agcttttatg caattgaggc 3270001 aacgctgctt gctaatccgc atgtcggtgt caacttttta gtgccgatat ggtcgatggc 3270061 gaatgtggcc caaggcggag cggggcttgc ggtattcctc aaaacgaaac aatcaagcct 3270121 gaagaaaatt gcgctccccg cttctctgac cgcgttttta ggcattgttg agccgattgt 3270181 attcggggta aatctcaaat tgatccgtcc ctttatcgga gcagccatcg gcggtgctat 3270241 tggcggagca tacgtggttg cggtacaagt tgtggcaaat tcctacggac tgacaggcat 3270301 tccgatgatt tcaatcgtgc tgccgtttgg cgccgctaat tttgttcatt atatgatcgg 3270361 tttcttgatc gcagccgtct ctgcttttat agctacattg tttctcgggt ttaaagaaga 3270421 gacagaataa ctggatttat tcgatttcat tcataaaacg ggggatgaaa ggacaaaaaa 3270481 gctatgaaaa ttaaaagaat cttaaatcat aatgctatcg tcgtaaagga tcaaaatgaa 3270541 gagaagattc tcttgggtgc aggaattgcg tttaacaaaa agaagaatga tattgtcgat 3270601 ccgtcaaaaa tagaaaaaac ctttatcaga aaagatacac ctgactataa gcagttcgaa 3270661 gagattttag aaacattgcc tgaagaccac attcagattt ctgagcaaat tatctctcat 3270721 gccgaaaaag agctgaacat caaaatcaac gagcgcattc atgtcgcttt ttcagaccat 3270781 ctttcttttg caattgaacg cctgagcaat gggatggtta tcaaaaatcc gctgctgaat 3270841 gaaatcaaag tcctttatcc aaaggagttc cagatcggct tatgggccag agcactgatt 3270901 aaagataaac tggggattca cattcctgat gatgaaatcg gcaatatcgc catgcatatc 3270961 cacacagcaa gaaacaatgc cggcgatatg acacaaacgc ttgatattac aacaatgatc 3271021 cgtgatatta tcgagattat cgaaattcaa ctgtctatta atatcgttga agataccatc 3271081 tcttatgaaa ggctcgtgac ccatctccgc tttgccattc agcatatcaa agcaggcgaa 3271141 tccatttacg agctggacgc agaaatgatt gacatcatta aagagaagtt taaggatgcc 3271201 ttcctgtgtg ccctaagcat cggcaccttt gtgaagaagg aatacggctt tgagtttcct 3271261 gaaaaagaat tgtgctacat cgccatgcat attcagcggt tctaccaacg gtcagtcgca 3271321 cgctgagaca aacaaaaaac gcttttgatc atctcaaaag cgttttttta tctgatttat 3271381 tggttgatcg ccggattccc aatcgtattc cacttcgtat aggacatgta atggaaatac 3271441 tcatcgcgat acggatgttt tgtattggag ttccaaggct tttctccgcc gcagaagtgc 3271501 acgattgccg ggttttctct tgtttcatta tattgcttcc gccctaacag agtcgatggg 3271561 gttttcagct ttaacatgat ataggtttga gcgttccagc gcggatgaag ttcataccac 3271621 tgatcataca agatcgcatt cagtgcatct tggtcatgca gcacaagaaa gtcttcgtct 3271681 gggtgttcat tgataaagtt gatgactttt tctgtgatgt tttgctttct ccaagactca 3271741 aaatcaataa tcatgatacc tgagttaaaa tacttccctg tatcagtgac gttcatttct 3271801 ttcaggcgtt catgctgccc cgcatcctca acagcggcta cggtgtatgg cgcaatgtct 3271861 aagtcccata gcttagaaat atcctctagg acaagcgcat cacaatcgat gtaaatcatt 3271921 cgtttgatgc tttcatcctt aattaagtcg ggaatcgaaa tgcggtaata cgcggctttt 3271981 gtaatatggc tgctctcaac cgcatgttca tacatgttgg tatccacttc taaaaactca 3272041 atcggcactc cgaatttcaa agtggtttct tccagtcttt ttttgttatc aggcttaatt 3272101 ccgccatcaa tgacgtataa ttttacctct ctctcctgat ccatgttagt caataaagaa 3272161 acgaacatcc cacctaaatg acgagcataa ttatcatctg cgcatgatac gatatgcatg 3272221 atttcatctt tcctcaatgg tattcatctc cctttttgtt gtacaagtta catacccttt 3272281 ttcaaaaaaa taaacacgtt ctccgacatt tttttaaaca gaatgtgtga tacaacaaaa 3272341 aaggtgtcat tttttgaaga tgcgataaag ccaataaaga atgaaaaagc ttgcgattgt 3272401 gatggcttca gccgagacga tataccacgg ccatggcccg agaacatcta agagagagga 3272461 accgcccggt tttttcgtca aatacatata attcgcgcca agccagcgat caatcagaaa 3272521 aatacagacg ccgtacacat taacaagcag gactgtcacc cataacgagc gctggcccat 3272581 tctgtaggtg ccaatcacag ccatcagcag acaggataaa aacacagacc cgtgagaaat 3272641 aaaaaagagg atatatcgga tatgcggaaa tgaaaacata ccgaggtcag gagtggcaag 3272701 agcctgaatc gaactgccga tgccgacaaa aaacaaaaac acaaacagct ttctgctttt 3272761 tgtcactaac ataatagctg acaaatacac cgacaggtca ctaagctgga gaggcaatga 3272821 agtgcgcacc gaccacctgt ccgtggcgac catccatatt tgatagccga tttgcgaacc 3272881 aagcaaaaga aacacaaaca gagaacgcaa aaaccggctg gccctcggct gcttgacctc 3272941 atcttggaac aaaaacaaca gaatggccaa aagggagata atcgctaacg tcactacatg 3273001 ctctgtcgaa aacagatgaa acggatcatg cttatagtcg gattgaacat atttttgcaa 3273061 aactgcaccc ccgttttcgg gtttttgttt attttggcgt tgtttgggct ttttttattc 3273121 aaccgatata tgggcttgaa gttcacacca gactctgtta aaattcgttt catagctaat 3273181 gattctgata atttaaggca ggcctaaaaa atggaacgtt cacatcaaca tcagcagctt 3273241 cggaaggaag aacacgatac actttctaag ctcaaacaaa tgcccgtcga gtcactcaac 3273301 ctggaagcca tttcgatcgc tacgaatctg tatcggtctg cacaaaggct ccgtgtcaaa 3273361 atggagactg aggttctttc tacctataac ctttcttgga ccgctttctc cattctttat 3273421 gatctatggg tatggggagc gctcgaaacg agaaaaatcg ctgagctgtc agggatatct 3273481 acagctacag caagcaacgt gatcaaaacg ctcgaaaaaa agagtttttg ccgtaaaagc 3273541 atcgacacaa gagatcggcg actcgtgttt gtctcaatca ccgattccgg caaacaagcg 3273601 atcgaagaac tctacccgga gtttcacaaa ggggaaacag agctcattgc gggaatgacg 3273661 aaggacgaac agaaaatatt gacagggctg cttagaaagg tagctgacaa tcttcataca 3273721 acataagctt tgacgggaat ccagtagcgg tttgtctccc tgtttcagag agccggcggt 3273781 aggtgcgagc cggcgcacag gcaaacgtga attacctccc caagctttct ttgtgaacct 3273841 tagtagcaaa gaacgggaaa ccgttattcg aatgagcgga agacaatgtc ttcaaccagg 3273901 gtggtaccgc gtgcattgag ccacgtccct tattgggatg ggctcttttt tgtgtttgta 3273961 aaaaaggagg aaaaatgatg agaacatttg agcagctcac agcgtcacaa caaaaagagg 3274021 tagaaagaca gcttcagcta tacatgacag gcgcccacga agtcataccg ccggaggaat 3274081 taaaggcaaa gctcgtgaaa tcaatttcca cgggcacgcc gcttaaaatt aagctcggat 3274141 tagatccgtc tgcaccggat gtacatttgg gccatacggt tgtgttaaat aagcttcgcc 3274201 aatttcaaga aaacggccac attgtccagc tgttaattgg ggatttcaca ggaaaaattg 3274261 gtgatccgac cggaaaatcg gcagccagaa agcaactgac tgatgaagaa gttcagcaca 3274321 atgccaaaac ctactttgag caattcggaa aagtgcttga tccagaaaaa gtcgagcttc 3274381 actataactc aaaatggctg aaaacattga atctagaaga tgtcattgaa ttagcaggga 3274441 aaataacggt agcccgcctg atggagcgcg acgactttga agaacgcatc gccatgcaaa 3274501 aaccaatctc actgcatgaa ttcttttacc cattgatgca gggctatgat tctgtcgttc 3274561 tcgaaagtga tattgaatta ggcggaacgg atcagcattt caatgtcctc atgggacggc 3274621 atttccaaga acgatacaac aaagaaaaac aagtcgtcat ccttatgccg ctcttggaag 3274681 gcttggatgg cgtcgagaaa atgtcgaagt cgaaacacaa ctacattggc attaacgaac 3274741 atccaaacga catgtacgga aaaacgatgt cactgcccga cagcctgatg aaaaagtaca 3274801 tccacttggc gacagactta gagcttgaag agaaaaaaca gctcgtaaaa gacttagaaa 3274861 ccggcgccgt tcatccgcgt gatgccaaaa tgcttttagc cagaacaatc gtccgaatgt 3274921 atcacggaga gaaagcagca gaagctgccg aacactcgtt taaaacagtc tttcaggaaa 3274981 acagcctgcc ggaagatata ccggccgtaa actggaaagg cgaaaaaacg atagcgatga 3275041 ttgatctgct cgtcaagcta aagctcctct cttcgaagag cgaggcgcgc cgcatgattc 3275101 aaaacggagg tgtacgcatc gacggagaga aagtaacaga tgttcacgcc aaagcagaga 3275161 taagagagaa tatgatcatc caagtcggca aacgcaagtt tttaaagctc caataatctg 3275221 atattccgaa acgcttatga cccttcattc ataagcgttt ttttgcaggt ataaagcact 3275281 gtcttttcaa aaacgctctc catcttgcag gaaactcctt tagcatcccg aaatattccc 3275341 caaccataca tttaggggag gtttattttt gatgaaaaag cttttgactg tcatgacgat 3275401 ggctgtttta actgccggca cactgctctt gccggcacag agtgtcaccc ctgccgcgca 3275461 cgctgtacaa atatcaaata gcgagcgcga gcttccattc aaagcaaaac atgcgtactc 3275521 taccatttct cagctaagtg aagcaatcgg ccccagaata gccggaactg cagctgaaaa 3275581 aaagagtgcc ctattgatcg cctcatcaat gagaaaatta aagcttgatg tgaaggttca 3275641 acgattcaac attcctgacc ggcttgaggg tacactgtct tcagcaggac gcgatattct 3275701 tctccaagcg gcgtcgggct cagctccgac tgaggaacaa gggctgacgg ccccgcttta 3275761 caatgcggga ttgggctatc aaaaggactt taccgctgac gccaagggca aaatcgcctt 3275821 gatttccaga ggagacctga cttattacga gaaagccaaa aatgccgaag ccgccggagc 3275881 gaaagctgtc atcatttata acaacaaaga aagcctcgtg cctatgacgc caaacctgtc 3275941 gggaaataaa gtcggcattc cggtcgtcgg cattaagaaa gaagacggcg aagcacttac 3276001 ccagcaaaaa gaagccacct taaaactaaa agcattcaca aaccaaacct cccagaatat 3276061 catcggaatc aaaaaaccaa agaacatcaa acatccagac attgtgtacg tgaccgccca 3276121 ttacgacagt gttccttttt cgcccggagc aaatgacaac ggctcaggta cctctgttat 3276181 gctggagatg gcgcgtgtct taaaaagcgt tccatctgat aaagaaatcc gctttatcgc 3276241 tttcggcgcc gaagagctcg gcctgctcgg ctcctctcac tatgtagatc atctatcgga 3276301 aaaagagctg aaacgaagcg aagtgaactt caacttagat atggtaggca caagctggga 3276361 aaaagcgtct gagctgtatg tcaacacatt ggatggccaa tctaactatg tttgggaatc 3276421 cagccgtacg gctgctgaaa aaattgggtt tgacagcctg tctctgacac agggaggatc 3276481 atctgatcat gtgccattcc acgaagccgg cattgattcc gctaacttta tttggggaga 3276541 cccggaaaca gaagaagttg agccgtggta tcatacccct gaagactcga tcgaacatat 3276601 cagcaaagaa cgcctccagc aagcaggcga tcttgtgaca gccgctgtct atgaggctgt 3276661 gaaaaaagag aagaaaccga aaaccattaa gaaacaaatg aaggcgaaag catctgacat 3276721 ttttgaagat atcaaataaa aaaagacggc acttgggtgc cgtctttttt aatccacttc 3276781 tttcttaatc cccagcattt tctcatctag gtaatgggca atctccgcgg cttctttcag 3276841 ctcatctgtt aattgcttag gaacgtcatt gttcaattta taataaattt tatgttcaag 3276901 gctcgcccag aaatccatcg cgattgtccg gatttgaatt tctgctttga cgtattccac 3276961 acggttcgtt aaattcacag gcatctcaat gattaaatgc aggcttcgat agccattcgg 3277021 tttgggtgtc tggatataat cctttacctt tacgattctc aaatcttcat gctgcttcaa 3277081 cacattcacg acattataaa tgtcagaaat aaaggaacag atgatgcgca cgccggcaat 3277141 gtcgtgaata tgctccttca tttccttcgt cgtaatctca cagccctttc tcattaactt 3277201 attcacgatg ctttcaaagc tttttacacg ggattttgta tgttcaatcg ggttgtgtcc 3277261 gtgaatgagg ttatattcct ggctgataat tgagaacttt gtatcgagcg catctagcgc 3277321 aaatttataa actaataact catttttcca atcttccatt actgttttta aatcgtccat 3277381 atgtgttaca gataaatcca tgttcgtcat ctcctttaac ggaactttat ccgctgtcca 3277441 tgtactagac gtccctgtct gctgcaaggt tctatgaatt tttttacaaa atgcggtcga 3277501 ttgtaacaaa aaaagaccgc atgaaacgag cggtcttttt tattatcgga aatagctgat 3277561 caataatccg atcgagagca ggaatccgaa aaatgtattt gtttgggctg ttgatttcat 3277621 tgcgacaatc atattcatcg gcatttcgtt ctggacgaag cccttcactg cctgaaccgg 3277681 cttaggcacg ctcaaaaaga cgacaaacag ccatgggctt gcggcaccgg taataaccaa 3277741 gccgacaacc cagatataag cgacggcaaa cgacgcagct aacagagtaa cagctccctt 3277801 atgccccatc aaaatcgcca atgttttgcg tccgcctttt ttgtcctctt caatatcacg 3277861 aatgttgttc gacaggttaa tcgcgccgac aagaatcgca atcgggatgg aaatcaaaat 3277921 gctctgcata ttgatcttat ctgtctgaat gaaaaacgaa atcagcacaa acaccgaacc 3277981 catgcaaatg cctgagaata attcaccgaa cggcgtgtac gcaatcggca gcggcccgcc 3278041 tgtatacagg tagccgatcg ccatgccgac aaggccgatc agcgcaagcc accagctgct 3278101 gctggcacaa atatagacac cgagcaaaat ggcaatcccg tatgaggcaa gagctaattg 3278161 caaaatcgtt ttaggcttca ttccgtggcg tacaatggcc cctccgattc cgactgattc 3278221 tgctgtatct aatccgcgtt taaaatcata gtattcatta aataagttcg tcgcgatctg 3278281 gatccatagg caagaaaaca gcatagccaa aaacagcagc agatcaacct tcacataaaa 3278341 catcgccaaa acggttccga gcagcacagg cacaaacgat gcggttaacg tatgaggacg 3278401 ggttaactgc caaaggatct gccccatgct ttctttttgc ggcgctgtct gaccctcacc 3278461 cttatttgtt tggttcatct tcctcttcct ttctattaaa aggcttactt tttttcagcc 3278521 ggcagcttaa taaaaaactc cttttgcttc cttatctatc ataatgactt ctcccttatt 3278581 tcacaagata ccgcaagaag gcgttttctt tcttattata cgcttctcgc cctgatttca 3278641 ttaggtttct gctttcactt gaacgaacag gtacagaaaa atttttttaa gtacattaca 3278701 ctttttaaaa gttaaaaaga tcttttgact ccaggtatct tttcctttat tatgaatcag 3278761 ctcgaaacat tccattcttg cccttgcagg tataaagatt cattttcaaa aacatacgcc 3278821 gatatattaa tttgagggag attagggaaa aaatgaaact ttttgagcat ctgatcgtca 3278881 aataatcatg tgattgtcga aaaaacggga agggaatttt tgatatgctg caattaatga 3278941 aacagctgta tgaaaaaccc gctgtcaagt ggacatgtca tacaggcttt tatttgatga 3279001 tactgcttgt tttgtttttt atgtatggtt ttcacaccgc gaataccggt tcatatattt 3279061 ataacgattt ctaattggag agagaataac tatgaaactt ttacatgcta ttcaaacaca 3279121 tgcggaaact tatccgcaaa ccgatgcctt ccgctctcaa ggccagtcgc tcacgtatca 3279181 ggaattatgg gagcagtctg accgcgcggc tgccgcgatc caaaaacgca tttctgggga 3279241 aaagaaatct cctatccttg tgtacggcca catggagccg cacatgatcg tttccttctt 3279301 gggaagtgtc aaagcgggac atccttatat tccggttgac ctgtctattc cgtccgaacg 3279361 gattgcgaaa attatcgaaa gctctggagc agaattgctg atccatgcag caggactctc 3279421 aattgatgca gtcggccagc agattcagac agtttctgcg gaagaactgc tggaaaacga 3279481 aggcggctct gtcagccaag atcaatgggt caaagaacac gaaacgtttt atatcattta 3279541 cacttccggg agcacaggaa atccgaaagg cgtgcagatt tccgctgcga accttcaaag 3279601 cttcacagac tggatttgtg cagactttcc agtcagcgga ggaaaaatat ttttaaacca 3279661 agcgccgttc tcatttgatt tgtctgtcat ggacctatat ccgtgccttc aatcaggcgg 3279721 gactttacat tgcgtgacaa aggatgctgt gaataagccg aaagtcttat ttgaagagct 3279781 gaagaagtcc gggctgaatg tgtggacatc aacaccttcc tttgtgcaaa tgtgcctgat 3279841 ggatccgggt ttttcacagg atctgctgcc tcatgcggac acatttatgt tttgcggaga 3279901 ggttcttccg gtttctgtgg ccaaagcgct gcttgagcgt tttccgaaag cgaagatttt 3279961 taatacgtac ggcccgactg aagcgacagt ggctgtcaca tcggttgaaa ttacgaatga 3280021 cgtcatcagc cgcagcgaat cgcttccagt gggcttcgcc aaaccagata tgaacatttt 3280081 cattatggat gaagagggac agccgcttcc tgagggagaa aaaggagaaa tcgtcattgc 3280141 agggccgagt gtaagccgag gctaccttgg tgagccagag ctgacggaaa aagcgttttt 3280201 ctctcatgaa ggccagtggg cataccgaac tggcgatgcc ggctttattc aagacggtca 3280261 gattttctgc caaggacgtt tggattttca gattaaactt cacggctatc gaatggagct 3280321 ggaggaaatc gagttccatg tcagacagtc acagtacgtt cgttctgctg tcgtgattcc 3280381 ttatcagcca aacggaacag ttgagtatct gatcgctgct attgtgcctg aggagcatga 3280441 gttcgagaag gaattccagc tgacaagcgc tattaaaaaa gagcttgccg cttctcttcc 3280501 ggcatatatg atcccgagaa aatttatcta tcaggatcac attcaaatga cggctaacgg 3280561 caaaattgac cgaaaacgca ttggcgaaga ggttcttgta tgacgcctta cagctcgttt 3280621 ttattcttta tactgcttgg cattcttctt ctgccgacga tcattctcgg cttaaacgga 3280681 aaaagatttc aagcatacaa catgttcata tctatcatta tattggcttt aattttttcg 3280741 cacgacttac acggggtcat cgcgctgtgc ctgtttacaa tatggcaggt gctcctgatc 3280801 agcggctatc tggcataccg gcagaaagcg aacagcggct ttgtcttttg cggagctgtt 3280861 atcgcgtcta ttctgccttt atttctgtca aaaatatggc cgtttctttc acacccgcag 3280921 ccgcatcatc cgccgcataa cctgatcagc tttttaggga tttcatattt aacctttaaa 3280981 ggcgttcagc tgattatgga agcaagagac ggactgctga aagaacagct gccattgcac 3281041 cgtctgctgt atttcatcct gtttttcccg acgatttcct ccggcccgat cgacagatac 3281101 cgccggttcg tcaaggatga acagaaggct tggacgaaag aagaatacgc cgacctgctg 3281161 tatacgggaa tccataaaat cttcatcggt ttcctgtata aatttattat cggctacgcg 3281221 atcaatacgt acttcatcat gaatcttccc gcaatcacgc acaataagat tcttgggaac 3281281 ctgctgtaca tgtacggcta cagcatgtat ttattctttg atttcgccgg ctacacgatg 3281341 tttgccgtcg gggtcagcta cattatgggc attaaatcac cagaaaactt taataaaccg 3281401 tttatcagta aaaatattaa agatttctgg aatcgctggc atatgtctct gtcattttgg 3281461 ttcagagatt atgtgtttat gagattcgta ttttggatga ctaagaaaaa gtggatcaaa 3281521 aaccgtatgg ccgtctcaaa catcgggtat ttcctgctgt ttatgctgat gggggtttgg 3281581 cacgggctcg cgccgcaata tatcatttac ggcctctatc acgccgttct gatgacgtgt 3281641 tacaactttt tcgagaagtg gaataagaaa tataaatggc tgccgtccaa ccgctggaca 3281701 accattctcg ctattgtgat cacattccat ttcgtttgct tcgggtttta tattttctca 3281761 ggaaaaccat ttcatcacca ccattaaagg agattagaaa gctatggatt ttaaacaaga 3281821 ggtattagac gttttagcag aggtttgcca ggatgacatc gtaaaggaaa atcctgatat 3281881 tgaaattttt gaagaaggtt tgcttgattc ttttggaaca gtagaattgc tgcttgcgat 3281941 tgaaaaccgt tttgatattt tagtgccgat cactgaattt gaccgggacg tttggaatac 3282001 acctaacaac attgtaaatc agctgtctga gttgaaataa tgaaaaagcg ttttttcggt 3282061 ccaattattt tggcgtttat tctattcgca ggcgccatcg caattccatc ttcatggctg 3282121 acaggcttca tcaccgataa gcgtgtgaaa gagtcagcaa cagccttgaa tccgagtatg 3282181 tttcaagggc tatatttaca agatcagatg ctcaaagatc cgacatatct tccgatttac 3282241 gggtcttctg agctttctcg gctggacgag ttccacccat ctaattattt tcaggtaaac 3282301 aatgagggat tcacgccata ccttgtcggc aaaggcggat cccagtcatt gattcattct 3282361 ttaaacttcg ctgcccacat ggatcagctg aagggcaaaa aaatcgtatt catcgtgtct 3282421 ccgcaatggt ttattaagcg cgggtctgat gaacagcatt tcgcgccgaa ctattctgcg 3282481 ctgcaagggc ttgatttggc atttaacgat cagatcgatc ctgaaattaa aaagaaaatg 3282541 atgaaacgca tgcttcgctt taaggctgtg caaaacgatg ccattctttc tgagctgtac 3282601 aaagcaatgg taaacggtca gacgtggaaa gtgaacgcgc tgaagccggc ggcgaaagtg 3282661 tattacagca tgctggaaaa gaaagatctg tattattcaa cgacagaatc atccgggcca 3282721 aagcgctata tctcgcagtc agtaaaggat aagtcatggt ctgaattgaa taaactagcg 3282781 gatcaatcgg gcaaacgcca ctccggttct aacgattttc acatcgacaa ccctgtctat 3282841 aaaaagctga agccgaaagt gcctaagctg aaagggaaaa acaaaggaag atcgtatgcg 3282901 gtgtcaccgg aatatggcga ctttgaaatg atgctcgata tcctgaagga tgcgggcgca 3282961 gagcctatgt ttgtcaccat tcctgttaac gggaaatggt acgattacac gggcttcccg 3283021 aaaaaaggac gcactgacta ttacaaaaag gtaaataaac aaatcagagc gaagggcttc 3283081 caggttgctg atttctcagg gcatgaatat gacccgtatt tcatgaaaga caccattcac 3283141 atcggctgga aaggctgggt gtatgtcgat aaagcaattg acgaatttta taaaaccgga 3283201 aaagtcactt catcctgagc atctcatagg acgcggctgc atatttcctg ctaagatttg 3283261 taatagtaaa ggaatcacag ccaacttaat taagaggtgt tacatccaat gaagatgaca 3283321 aataatacgg ttttaatcac agggggttct gctggcatcg ggcttgaact ggccaagcgc 3283381 ctgctggaac ttggcaatga agttatcatt tgcggacgca gcgaagcacg tcttgcagaa 3283441 gcgaagcagc agctcccaaa catccataca aagcaatgtg atgttgcaga ccgttcgcag 3283501 cgggaagcat tgtatgaatg ggctttaaag gaatatccga acttgaatgt tctcgtcaac 3283561 aacgccggca ttcaaaagga aattgacttt aaaaaaggga cagaggagct ttttgtggac 3283621 ggtgatgaaa ttgaacttaa tttccaagcg cctgtccatt tatccgccct tttcacacct 3283681 catttgatga agcagcccga ggcggcaatc gttcaggtca catccgggct tgcgtttaac 3283741 ccgttagctg tttatccggt gtactgcgca acaaaagcgg cacttcactc gttctcgctt 3283801 acgctcagac accagctccg cgacacgagc gtggaagtga ttgaaatggc accgcctatg 3283861 gtggacacgg gcttaaacca aaaatcacgc gataaacaag gcctgacgta ccggggcatt 3283921 tcatctgaag aatatgttca atatttcttg gacggcttga aggaaggcaa acaggagatt 3283981 acaaatgaac gtgttgaagg tcttcgggat gccactcgcg ccgattatga caggttattc 3284041 gagcaaatga acacgcagga gaattaattt ctcctgcttt tttcatatga atttcttaca 3284101 aatttgagca aacctattgc gattatttgt tgaaggtata caatagaata taattatttt 3284161 caaataagtt tgataatata aacaatttaa cagcagggag attgaccatg actaaacaaa 3284221 caattcgcgt tgaattgaca tcaacaaaaa aaccgaaacc agacccaaat cagctttcgt 3284281 tcggaagagt gtttacagac cacatgtttg taatggacta tgccgcagat aaaggttggt 3284341 acgatccaag aatcattcct tatcaaccct tatcaatgga tccggctgca atggtctatc 3284401 actacggcca aaccgtgttt gaagggttaa aggcttacgt gtcagaggat gaccatgttc 3284461 tgcttttcag accggaaaaa aatatggaac gcctgaatca atcaaacgac cgcctctgca 3284521 tcccgcaaat tgatgaagaa caggttcttg aaggcttaaa gcagcttgtc gcaattgata 3284581 aagactggat tccaaatgcg gagggcacgt ccctttacat ccgtccgttc atcatcgcaa 3284641 ccgagccttt ccttggtgtt gcggcatctc atacgtataa gctcttgatc attctttctc 3284701 cggtcggctc ttattacaaa gaaggcatta agccggtcaa aatcgctgtt gaaagtgaat 3284761 ttgtccgtgc ggtaaaaggc ggaacaggaa atgccaaaac cgcaggaaac tatgcttcaa 3284821 gcttaaaagc gcagcaggta gccgaagaga aaggattttc tcaagtactc tggctggacg 3284881 gcattgagaa gaaatacatc gaagaagtcg gaagcatgaa catcttcttc aaaatcaacg 3284941 gtgaaatcgt aacaccgatg ctgaacggga gcatcctgga aggcattacg cgcaattcag 3285001 tcatcgcctt gcttaagcat tggggccttc aagtttcaga acgaaaaatt gcgatcgatg 3285061 aggtcatcca agcccataaa gacggcatcc tggaagaagc cttcggaaca ggtacagcag 3285121 ctgttatttc cccagtcggc gagctgatct ggcaggatga aacactttcg atcaacaacg 3285181 gtgaaacagg agaaatcgca aaaaaactat atgacacgat tacaggcatt caaaaaggcg 3285241 ctgtcgcaga cgaattcgga tggacgaccg aagtcgcagc gctgactgaa agcaagtaag 3285301 aaaaaagccg gcccattaca ggccggcttt ttttacgctt caattttgtt gaaaaactgc 3285361 ggcagatacg ctttgtgcgc ctctagcatt tcgtctaaaa tctgtttggc cacagtatcg 3285421 gacgggacaa gcgggttaat cgtcatggca aggagcgcag tttgatagtc acctgtaact 3285481 gccgcttctg ccgcgacacg ttcaaaggat ttgatttgct ggacaaggcc gcggacagac 3285541 accggcaagt cgccgacagc aattggctta gggccggttt tcgtcatcac acagttcact 3285601 tcaactgcgg aatcgtctgg aatactcgct attgcaccat tattgatcgt gttcaccggc 3285661 tgaatgtcat gtttatcatt ataaatggag ctgattaagt tacatgctgc atcactgtag 3285721 taagctccgc cccgtttttc cagctgcggc ggtttgatcg caaggtttgg atctttataa 3285781 agctcgaaca gctctttttc gaccttctgt acgacttcag cgcgggtgcc ctccgtttgt 3285841 gatgcttcca gttcgtgctc cagcatctct tttgttttaa aatagtaacg gtgatagccg 3285901 caagggatga cattgagcgc ttttaagaaa tccggttccc attcggcgcc tgagatattt 3285961 ttcatcgtca tcgcgttttt cgggtcgccc atcgcctcga tgacttgctc cttcacactt 3286021 acgccgtcca agaaaacatc cagcccgaat accatatggt tcagtccggc aaattggact 3286081 tctacgcggt ccacatctac atcaagcgct ttggctacgc ccattttgat gccgattgga 3286141 acattgcaaa gaccgacgac tttcttcagg ttggagtagc gaagcaaggc ttctgttacc 3286201 atgccggcag ggtttgtgaa gttaacaagc caagcgttcg ggcaaagctc ttctatgtcc 3286261 tttgcgatct caaggatgac cggaattgtg cgcaatcctt taaacagacc tcccgggccg 3286321 tttgtttcct ggcctatcac tccgtatttt agcggaatgc gctcatcctt tgctcttgcc 3286381 tgcaaaagtc cgacgcggaa ttgggtcgtg acaaagtctg cgtctttcag cgcctttctc 3286441 cggtcgagcg taagatgaat gtcaatcggg acgccagctt tttcaaccat ccgtttggcg 3286501 agtgtgccga caatattcag cttttcttcg ccctcgggga tatcgacaag ccataattca 3286561 cggacaggca gctcatcata ccgtttaatg aacccctcca ctagctcggg cgtatagctt 3286621 gaacctccgc caatcgttac aatcttcaat ccttttgtca tatgcttgct cccctttgct 3286681 cggtgatttt ttcatataac tcaatgatct ctgcagccat atccttcact gtcattgcat 3286741 tcattaaatg atcctgtgca tgaaccatca gaagcgtcat ttccgtcttt tctccgcccg 3286801 cttcattttg gatcagctct gtctgataat gatgggcttt tgacaattct tcagcagcgt 3286861 cttgaagctt tttccgcgct tcttctgcgt caccgctttt cgcagcggca atggcctcca 3286921 ttgcggagct cctaccgttt cctccgtgaa ggatgatttg aaaaatgatt tgttccattt 3286981 cctcattcac gcgattcact tcctttctct acagagccgc ttctttgtca tctgttgctg 3287041 caggcgtttg gaccagctcc agatcgtttt cttctttcag cttctgctta tcccacattc 3287101 tgaagaatgg atagtagaca acaaaggaca cggcaatatt aatggcttgc atgaccgcgc 3287161 ctgagacttt tcctcctgtc gccaagtagc ctgaaaagat cggcggcatg gtccacggca 3287221 ctgcgatacc cgccggtttg gcgacaaggc cggtgctcat tccgatgtac gtgagtgtca 3287281 ctgtgacaag cggcgtgatg ataaacggaa gtaagagcat tgggttcatg acgatcggca 3287341 ttccgaatat aatcggttcg ttaatattga agatggccgg gccgaccgca agcttcccga 3287401 gctgcttcat ttgtttgctt cgggcgcgca ggaacatcgt gacaaccagt gccaatgtgg 3287461 cgccgcttcc gccaatattg acccagatat cgaaaaattg ctgggtgaaa atcttaggaa 3287521 gctcctcacc ggcttggaat gcgatccggt tggcatccat tgcgccgtac caaatcggtg 3287581 ccatgacgcc gccaacaatg tttgcaccgt gaaggccgca ggcccataaa agcattttga 3287641 cggcttcggc gacaaggctt cctccaaggc ttcctcccag aatggaaagc ggagtcccca 3287701 ataaaacgct tacaatatta tgaaggcttt caaacggtgt cgcttcaaca atcagccggg 3287761 ctgcccaaat taggaagatg acggcaaagc cggggattaa cgcgacaaat gacttgctta 3287821 ccgccggcgg gacaccgtcc ggcattttga agactaaatt gcgctggata ataaggcggt 3287881 aaatctctgt ggacaccatt gcgataatca tggcgacaaa taagcctttg cttcccatga 3287941 gcgaaagcgg aatcccgccg ccaaccatga tttctttcgt cgcgccatcc ggcataaacg 3288001 gcacttgata aggtgttgct aataaaaatg ccgcaaggga aatggctccg gccgacaagg 3288061 catcaacacc gtatttctcg gcgagccggt aggcaatgcc gaacgcggcg acaagaccca 3288121 taatttcaaa ggtcgcgtcg actgggtagg ccagtttttc agaccaggag ctgccaaacg 3288181 tttttgccat aaactcagcg tatcccggga tcgggaggtt gccaatgatg aggaaaaagg 3288241 aaccgatgat aatcaggggc atcgtgagga tgataccatc acgcagcgcc tgcaaatgac 3288301 gctgtcccgc aattcttccc gctataggca tgaccttttc ttctaagatc tgattgactt 3288361 tattcacata gcccgcccct ctctatgaca catgtccaag ctgttcagct gatttcagca 3288421 cttccgcccc attgcacgtt ccataatgga cggtattaat gacgtctacc ggaaccccct 3288481 ttgactctcc taattttttg agctgcggaa gcatgtaacg gacttgcgga ccgagaagca 3288541 atacatccgc tttatcgata tgattttgta cagaatcgcc tgaaactgcc caaatggtat 3288601 agtcttttcc ctgttcctgc gcactttttt ccatcttgct caccagtaag ctagtagaca 3288661 tgcctgctgc acaaacgagt aatatattca tgtaaaagac cccctagagt ttgatcaatt 3288721 ttgtaatgtc ctgctgttgc tatcatcata ttatgaaatc gctttcataa acactcaggg 3288781 tttttccgca ggcaacggaa aaaaggtata tacaggctgt cagctcagca ttttttggtc 3288841 aaacacatcc gaaagctctt gatatgaacg gcatttgatc agctggttca tcgccgccgg 3288901 gtcatccaaa atgctgccaa gcagtttata catgctttgt aaatccgctt tgttctcctt 3288961 ttcgacacaa agcagacaga caaattgaac tcgctgactc tcccaatcga tcggtttttt 3289021 gagcgtacaa acggcccaaa acgttgtttt cgtctgcgga acaagcgggt gcgggatggc 3289081 aacaagattg ccaaaacacg ttggcgacat gtcttctctt tcaaaaatgg aatctatgat 3289141 ttcttcatcg gcaaagccgc attcgaccac tttctgccct aaaaattgaa tcacttcttc 3289201 ttttgagcgc agatcctcct gaaaaaaaac gagttctttt tttaggtagc gattggcttt 3289261 ttccttttca tcactcagaa tagattctat ttttgtaaag tcagttccgc ctaagatggt 3289321 gttaaccttc agtactggta cagggagctc ttttttaatc ggaatggtgc tgatgacaaa 3289381 atcaattgat tcgtaggaca tttgatcaag actataatac tcagccgttc caagaatatc 3289441 gagccgcttg ccgaaatggg aacgcagttt ttcgcgcaga agctgggcgc ttccggctcc 3289501 cgatgcgcat acaatgatac agcgtttcgg cgggctttct gttttttttc gttcaatcgc 3289561 ggcgccaaag tggagagcca aatatccaat ttcgttttca tgaatctcaa tacccgtttg 3289621 ttcctttatc acgattccgg caatgatccc ggcttcaaaa gcgagtggat aatgttcctt 3289681 gatcgctgcc agcatcggat ttcgaagatt catgccgtat cggttgcggc tgatcgccgg 3289741 cttcatatgc agtgccaagc cgattttcag ctctttgtca tgcaggatgc caagcttcag 3289801 ttcacgatca acagctttga tcatggcaag tgtcagctga tcggtttcct cttctattga 3289861 aaatgtgtcc tctccgcatt gtgattgtgt cattcgtttt gtgccaagga gatgcatggt 3289921 gatgtaggcc gtctcgtctt tcggaaacgt aacggaaagc tttgattcca gctcttttac 3289981 gatggcttct gcagcctggt actccttttg atgcaggata tgatccatat ctttcgggaa 3290041 aagagaaaca tagttttccg ttctgatccg tttacaggcg atagcgatat ggataatgag 3290101 gttattcagt cccatgttgg acagagggat gcggtcgttt ttcatttttt tcaagatggc 3290161 ggaacggatg atctcaattt cttcttttgg caaaatatca gccttttcat ttaaaacatc 3290221 tatctccgtt tctctttcat caacaatgta ctccgccatg cagtacctca tctgcacctc 3290281 gtccccgcgc agcttgaagc cgtaattcgg acgtgtttcc atgacgatgc ggtaaggcag 3290341 cagacgtttc tttacttcct ttaaatccgt ttggagtgta gattttgaga taaatagttc 3290401 ttcagcaagt tcatcgagct tgagataatg gtccgccagc agcagacgtt tcataagata 3290461 ggccattctc tcctccggca ataccggcag gccctttttt tgctgaaatt catcttgcag 3290521 cagtgttctg aatacttgct cgtcatcaat gcggagcttg tagccggagc ctcttacaga 3290581 ttgtacaaag gcaccgtggc cgcttagcac accttgaagt tcctttatat cattgcggac 3290641 tgtccgcgtc gttacgttta attgcgcggc aaaaaacgaa cttgtcaccg gggcttcagc 3290701 cgccatcagc aagcgcagaa tatcacgtag tcgcccatga agcatgagaa aaacctccta 3290761 actagtagat gcagggattc agtgaatagg cagaaaggat gatgaaggga tgcgaaatgt 3290821 atataaattc tataatggag agaatggcaa gtcaatgaac atccggagga ctagagggaa 3290881 aactgaccta taaaaaaaca gccgggatca gccggctgtt ctagatgcgg acatattctt 3290941 ttgtttagac gccttgcggt ccttcatgat ttttcgaaca atcgggtaaa tgaccggcgc 3291001 ccatttgata acggttttga tcatcttttt caaagctccg attctccctt cttttttctc 3291061 aaccattccc ctgattgcct cttccttaaa catgctaacg cgacacgtac ctgtttcccg 3291121 tcacccagaa acgccatgga taatcgcgtg cctccccgct gttgtcaatg ccgatgcgcg 3291181 ggccggttga aattgcttcc ggtgtgtacc cgctttcgat gtaaagcggc tgttccgtga 3291241 tccagcgtcc gtagtcattc atcgtgacgc caagcgcttt cgtcagcttt cctggtccgt 3291301 ttgtccattc cctcggactc ctgcccggcc ttctctcctc cattaacagc tggccttcat 3291361 gcggctcaat cgccctgatt aatactgctt gcgggacatc ctcttccgcc gcaacgacat 3291421 tcagcaatgt atgggtgtgc atcacgtatg tatatacccg cccagcttct gcaaacatga 3291481 tctcagtccg cttcgtccgg cggttgttaa agctgtgggc cgctctgtct ccagccccca 3291541 tataggcctc tgtttccaca atatagcctg acgctgtgcc ttcgtctgtt tcttttacaa 3291601 gaaggcagcc cagaagcgat ggggcaagct caagagcggt tttttgataa aacgtgatgg 3291661 gcagcggatt tttttctctc gtcacgaatc gacctctcct tttaccgatt tttgtacatt 3291721 gtaccattcc cgaagcagat caaaaaaaac ggctgtttta aaatctttcc attcagggaa 3291781 tattgttacc gttcaaaaaa ggagggccaa ccattgaaag atgatcatca aaacaagcag 3291841 caccaatcaa atgcccaagg gagcgaggaa gcgttttctc ataagacatc cgggaaaaac 3291901 gagtcagagg ataccttaac gaataggcag gggcatcctg ttactgacaa ccagaatgtg 3291961 agaaccgtcg ggaatagagg gcctacaaca cttgagaact atgattttct cgaaaagatc 3292021 agccacttcg accgggaacg catcccagag cgggttgttc atgccagggg agcaggtgca 3292081 catggatatt ttgaagcgta cggaagcttc ggagacgaac cgatttcaac atacacaagg 3292141 gccaagctct ttcaggaaaa aggcaagaaa acaccggcat ttgtccgttt ttcaactgtg 3292201 aatcatggaa aacactcgcc tgaaacattg agagacccgc gcggttttgc tgtaaagcta 3292261 tatacagaag acggaaactg ggatttggtc ggaaacaacc tgaaaatctt ttttatccgc 3292321 gacccgctga aatttccgga tcttgtacac gcatttcagc ctgatccagt gacaaacatc 3292381 caggatggtg aacgtatctt cgatttcatt tctcaatctc ctgaagcgac acacatgatc 3292441 accttcttgt tttcgccttg gggcattccg gccaactacc ggcaaatgca gggttcaggc 3292501 gtacatgcct ataaatgggt gaatgaggag ggcaaggccg ttctcgtgaa ataccatttt 3292561 gaaccgaagc agggcatccg caacctgaca cagaaggaag cagaagagat tcaagggaaa 3292621 aactttaacc atgccacaca ggatctatat gacgcgattg aaaatggcga ttatccagag 3292681 tgggaagtat atgctcaaat catgagcgat gatgagcatc ctgaactgga ctttgatcct 3292741 cttgatccaa caaaactgtg gtataaagac gatttcccat ggaaaccgat cggcaaattg 3292801 gttctgaaca aaaatccgga aaactaccat gcggaagtgg agcaagcttc atttggaacg 3292861 ggagtgcttg tcgacgggct tgatttttca gacgacaaat tgctccaggg gcgtacgttt 3292921 gcctactctg atacgcagcg ctaccgtgta ggcgcaaatt acctgcagct tccgatcaac 3292981 tcgccgaaaa agcatgtcgc caccaaccag gaaggcgggc aaatgcaata tcgggtcgat 3293041 agagcagaag gacaaaaccc gcacgtcaac tacgagccat ccattatggg cgggctgaag 3293101 gaagcgaagc aagacggaaa agaccatacg ccgcatgtcg aaggtgatgt aaagcgtgaa 3293161 gcgattgaca gaacaaacaa cttcggacag gctggagaaa cgtaccggag atttactgaa 3293221 tttgagcgga acgaattgat tacgaatttg gtgaatacgc tttctacgtg ccgaaaagaa 3293281 attcaggatc aaatgattga gaatttcaca aaagctgatc ctgactacgg aaaacgcgta 3293341 gcagaagggc taaaaaaggt ctccgaaaac aacagcaacg ggccgatcgg cacaactgaa 3293401 acggaacagg ctgcaaagca ggctgaacag gagagtcatc cgtctgatcc gtattaacaa 3293461 cagcgaacag ggctttttta gaagccctgt ttttttattt ttctattgaa acgctttcaa 3293521 taattgtgtt gtacttggaa ggaaaggggt ggagagatac gatggaatta cagcaggact 3293581 tgattcctca gaaaaaaaca atcggcgctt tagatcacgc cgttttttta tgcatggtat 3293641 tttgtttctg gttttcaggc tatatttacg ttcctgtatt cagtctgtat ttggaggatc 3293701 tgcacttttc atatggcgca atcggcatca ttctcggcag ctacggggtc acgcaaatcc 3293761 ttctgcgatt cccgctcggc cttttgtcag acatcctgtt ttccttgcgc aagcaattgt 3293821 taattgccgg gttcggcttt tccgtcctca gcagcctgct ttttctgatg tttgattctt 3293881 tcttcttcgt gctggccgcc cggcttttcg cgggaatcac tgcttctacg tgggtgatgg 3293941 cgaccatttt atacgcacat tatttcaaca atggcaatgc atcaaaagca atgggcatca 3294001 tgcagttttt taccgtcatg cctcagtttg ccagcattgt gttctgcggg ctcgccgcag 3294061 cccatttagg gaggcaggtt cctttttgga tggcgctggc agcttctgcc gcaggtctgg 3294121 tgatctgctg ctttattcag gatccgtctg ctcctcccgc aaaccgtggc accattcgtg 3294181 tcaatcagta catcaaagat acattgcggc tgccaaagct gaagcttttc accatcctgt 3294241 ctatgacggc ccatgccgta ttatttatca cagtgtttgg ttttacgccg ctttacatga 3294301 atcagctcgg aatgggcgac gcggagctgc tttgggtgat gagcgccttt ttcctcccac 3294361 acgcagccgc cacattaagc tttgtgtttc tgcgctttac aagccgtatc gcttactccg 3294421 tgatgctcat tagtttcgct gtcaccgggg tctgtttgct atatgttcct tttttagctg 3294481 cattgttcac ggtttgcatc acacacgcct gtattgggct ggcgctcggc ttcgtttttc 3294541 ctctgctgct aagccatgtc gtcgaaatca gttctgcccg tttaaaaatg tcagtgatgg 3294601 ggttttacca atcattttat gcgctaggca tcttcctcgg gccccttctt gccggaaaaa 3294661 tcgcacagct tatcgggctt gcgggagttt tttatggagc cggttctctg gcatttgccg 3294721 ccttttttgt gatgctcgcg caaaaacgta acatgatcaa ttaatagctt tcataccgcc 3294781 ggaagcgcca cacagaaaac acggccagaa gcatgatgca cagaatggag aaagtgagtg 3294841 accatccgaa aaaatctgcc cgctctccat gaagaaggat atgctccgcc tgcttgcaaa 3294901 tctcagccgg aagccacttc gcaccatctg gaaatagtga aacagcaaag gaaacggctg 3294961 ctgtgagccc gatcccgcaa gccgcagctg ctccgacaga ccggaatatc gtacttccgg 3295021 caaggccggc ggtcacaata aatatcaccc aaagagcgta aaggccaagg cttgcggcaa 3295081 agcggctgaa tgatgcgtcc tcaaacagca gccggacgta atagtaagca agcccgtatc 3295141 cagctgcaaa cgacataatg ccgatcacgc tttggatgag ccatttactc acgatataat 3295201 gggctgccgt cacaggccgc gacataatca gcgctgttac cccttgattt ctttcattgg 3295261 ctacactgcc catcacgcta aagatgacca gagccatgcc aagcgtgttg aattgagaaa 3295321 gcgtgctgac catcacttca gacccggagg gcatcgtaaa actgattttc atgccgtcag 3295381 gaaggttccc tccatgtgcg atgatttccg gcatataata aatggtcagc ggctgtgtca 3295441 gcccgacgat catcatcgca atcggcagcc aaatcagctt gccgcttttc catccttcca 3295501 gccactcctt ctgcaatagc gccatcatca ccttcatgcg tgcaccacct ttagatagac 3295561 gtcttctaga gactccgttt tctgttcaaa gcgggtgacg gtcaatccct ttcggataca 3295621 gtcacttaat aatgaccggc cagcgtgtat atcaggcagc tcgaaaaccg cttgggacgg 3295681 attcttatag acaatagctg agacgtaagg cttctcttca agccaacctt ccagcttctc 3295741 tttcactgaa agggtaaaaa cgttcgtttg ctgctgttgt ttcagctcct gtaactcgcc 3295801 tttccatgaa atctcaccgt ttttcataat caccacttga tcacacacct gttctgcatc 3295861 gtgcaaaaca tgtgtagaaa acagaacggc catatgcttt ttcagctccc gcatcatgtc 3295921 cagcacctcg aaccgtcctg tcggatcaag cgcagacacc ggttcatcca atatcaaaaa 3295981 cttcggttta tggagcagtg cctgtgccag accgagtctt tgtttcatgc ctcctgaata 3296041 gcccccgatc cttttgtgcg ccgcttcgtg caaaccgaca aattccagca tctcgccgat 3296101 tttctcttgg cattttctct tcgaaaggcc ggacagtctc cccgcaaatg tcaaaaattc 3296161 atttgcggtc atccacgaat aaaaagcagg atactgcggg aggtacccaa tcaaacgccg 3296221 atccagcttt ttctctccta acagctttat ggttccagag gttggcgaaa gcagtccggc 3296281 cagcatttgc agagtcgtgg ttttgccggc tccattaggt cctaatagtg cgacacactc 3296341 attttcattc acgtgaaaac tgacattctt tacagcttca tggtgcctgt acgatttgca 3296401 taatgattca atagacagca tatcggctta cctttgcttt ctgccgacgg tgaaaaataa 3296461 aatcggcccg ataatattga tacatacgat gattgcagcc cacatccact ttggcccgtt 3296521 cgtccgctct tcttttatac agctgataag ggcaaacacc gccaaagcca gctgtaatac 3296581 aatcagcggc aaaatcattt cccaagaaat attcattgct tgatccccct tttcttccga 3296641 tccggcctaa tgacaaaaaa gtaataacaa atcagaggca tcggtgcttg aatcaatccg 3296701 acaatccccc aaacccatgc catgtgatta cgttttttcg catcaataaa taaaaagatt 3296761 ccctgcgcca atacgatgag acaagccgca accgttatga taatttctgt ttgtgtcatc 3296821 cgcgtttcac ctcgcattcg ccgagatgcc tttttttctc agccgcaatc aaaatcggca 3296881 gcaccgcaag cacacaaacc tgaagcacaa taaacacagc aggagcttga gtgaaagcta 3296941 agattgcagc actcacaacc atcagcgcgc agaatacaaa taaaatgatc tcttgaagaa 3297001 gtttttttct gtattcagct ttcatttgtg acagctggtg aagcagttct ttttgattcg 3297061 gtatagaggg attggctgtt tgatcaattt ttttccattc tgactttaaa tgatcagaaa 3297121 gcttttcttt attcatcatc ccactccttt ctgatttgct ggagcccttt atgaactctg 3297181 gactttacag tgccttcttt gatttgaagc atcaccccga tttcagcgta ggtatagccg 3297241 tagtaatgcc ttaataaaac cggtgtgcgc agtttagggt ccagctttga aaacagatcg 3297301 agcgtttcgc tccactctgc ccctttcgcc gacacgtccc acttgatctt gcggattgtt 3297361 tcctccgtaa ctgtctgatt ccgtttccat tctctctttc tctttttctg gtgatcgaga 3297421 tagagccgcg atgcaatgga gatcagccat gtggagaatt ttgaacggcc ctgaaagctt 3297481 cttaaatgga tgtacccttt cagaaaggtt tcctgaacaa gttcctcgct gagatcgggg 3297541 tgaagggaaa gctttaacaa gtatttatat aagaaagaat agtgatagtg gaaaagggct 3297601 gtaaacgcct cgtcgtttcc ctctttcgcc tgctggatca gccgctgttc ttcttgtgta 3297661 tccaatgacc gtgatccccc cttttttgtt tttctgcctt atgagacgac accggattca 3297721 aaagcgttca tcttttttac aattcttttc agccattgac agatcaggct tcccggccgt 3297781 ttggctgcat atccttattt gtaaaccccc ttatagtctg ttaagctatg actttatgtc 3297841 gatttcaaaa aaacatccaa tatggaggac gatgcattga aagtagaaag gcgaacgatt 3297901 gaatatattc cgaatgaaga aagacatggt aaagcgaaag atttatttcc cgtatggttc 3297961 ggggctaata tgcatatcac cacgttagtg accggcacga ttcccgttgc aatgggactt 3298021 aatctgtttt ggagtgttgc cgctattatt tgcggaacct taatcggtgc catatttatg 3298081 gcttctcatt ccgcgcaagg ccctcagcta ggcatcccgc aaatgattca aagccgtgcc 3298141 caattcggcg taatcggagc gattcttccc ctcttcttag tcatgtttat ctaccttggt 3298201 ttcttcgcaa gcagcacgat tctggcggcc ggaaccttaa gcagctttgt tcccatcccg 3298261 ggatcatgga gcattatagg cttaagtgcc gtatgttttt tactcaccat tttcggccat 3298321 gatttgattc acaaaatgca aaaaatcctt tcttggacct cttttgctgt attttttgct 3298381 gcaacgattc tcatttttca attgccgatt ccggcaggca gctggatacc cggagcgatt 3298441 gatctgccaa ttttcctagt ggcagtcagc gcagttgcga cgtggcagct tgcctacgcg 3298501 ccgtatgttg ccgattattc aagatatctg ccagttaaaa caccggcttc aaaaacattt 3298561 tggtacagct atgcaggtac atctgtcagc tccatctgga tgatgctgct cggcgcattg 3298621 ctgacaacct cacttcctga ctttacggca aactcaggca gccagattgt ccaattgttc 3298681 ggtcccttct cgtttattat gctgatcatt gtgctatttg ggcaaatggc aatcaatgtt 3298741 tttaacctgt atggggcttt catgtccacg acaacaacgc tggagccgtt tctgaaatta 3298801 aaagtcacgc ccaaagtcag aatcatcatg atcctgggtg tcacgcttgt cggcacagtc 3298861 ttaagcctac tgggacagag caattttatg gaactgtttt tgaattttat ctttttcatc 3298921 agttatttct taattccgtg gacggcaatc aatttagtcg attactactt cgtccgccac 3298981 ggaaagtatc aagtcaaagc catgttcgac gtaaacgggc cttatggaaa ggtcaattgg 3299041 atcaccacaa ttgcgttcgt tctgtctatc ttgctggaaa ttccgtttat caacacaagc 3299101 ttttacatcg gaccgcttgc caaaatgttt ggcggcggag acatcgcatg gattatcggc 3299161 ttggccgtgc cttctgtgct ttactatgta ttaatgaaac cgcgtctgaa aaaacgggcg 3299221 gggtatcaag aaaagctgtc ttctctctga agacagcttt tttatcattc aaatcgtttc 3299281 cacacgcggg gcaggatgtc agatagctca tgagcgagca acgtatgagc ggagtgctcg 3299341 tccgtccaga gctcggcgca cgcaccatgc aaatagaccg cgtttaatac ggcgtgcttt 3299401 ggatcttcat ggcagcagag catccccaat atcatgcccg tcagcgtgtc accggttccg 3299461 cccttggcga gcgccccgtt tccggttgga ttgagccagc agtctccatc aggaaacgcg 3299521 atgacggttt ggtttccttt taacacaatg acagtctgca gctgagccgc ccattccttt 3299581 gcatattccg ctcttttttt ctgcaattcg ttcacgggca cccctgtcat tcggaaaaac 3299641 tcgcccgggt gcggcgtgag gatgacgggg ccctcccgtt tcggatatgt gcgcttcgcc 3299701 agcgctccgg catccaaaat aacaggacaa tcagccgtaa gcacatgatc gactgcctgc 3299761 tgtacgcttt ccgtttgcgg aaggcccggt ccgatggcaa tggcccggta cgtctcttca 3299821 agctgagcat ccgccgcctt tttccagccg tcacgccaat aggtcgcctc gggcaaaaca 3299881 ggaacaatta gcgggattac gttttctgat gtaccgatga caagcttgcc gagaccgctc 3299941 cgcatggccc caagccctgc aagcagcgct gctcccggca tgtcgtcact tccagccagc 3300001 agcaaagccg taccgtacgt gcctttatgg ctctccgcat ctctttcagg aagcgtggcc 3300061 cttacatgct cttccgtcca aaatggaaca ttcatctcta tccctcctct gctttctttt 3300121 cctatttttc ctgtcccttt tctttttcaa acaaaaaaga cagcctttta gggctgtctt 3300181 ttattttaca ggaacatcaa ggtgatacag gcggcgatat cgttcgtttg ccgccagcag 3300241 ctcctcatgg gttccttcca tttctgtttt gccgttttcg agaaatacga ttttatcggc 3300301 tgcttccact cccgcgagat ggtgtgtaat ccataaaatc gtttttcctt tcagcacctc 3300361 aaacaccgtt tccatcaatt cacgttcggt aataggatcg aggccgactg ttggctcatc 3300421 gaggatgatg atcggtgtat cctgcagcaa aatcctcgca agtgcgatcc gctggcgctc 3300481 tccaccggaa aaacggatgc cggtttcttg tacagaggta tgatatccgt caggcaatga 3300541 ctcaatgtag tcatgcagct tgacctgctt tgcggcgcgg cgcacatcct cgtcgcttgc 3300601 ttctccgttt ccgagcctga tgttgttcaa aatgcttgta tcaaacaggt gcggtttttg 3300661 atttaacacg gccaccgcat ccgcaatctg atcctttaac agcgctgtct ccactccgtt 3300721 taacgtcaca gaaccggagt ccggtttcaa ggcgccttcg attaatgcaa gcgatgttga 3300781 tttcccagag ccgcttcggc cgagcagcgc cattttttct ccttggcgca gcgtaaagga 3300841 aaagttgtgc agcacttggc tgctgttgtc ataagaaaac gtcacatcac gaaaggccaa 3300901 ggtgacatct tgaagatcga gaatttgatc ccctgattca gtttgtgacg cctccggctg 3300961 aggagccaca ttgttcatgc gtctgataga atcctgatag cccggcactt cgcctaaggc 3301021 atccgaaagc ggcaaaaagg cttccgtcaa cggaaacacc actagcacaa aagcggcaat 3301081 catcgtttta gcgagctcgc cgtccgcttg ctgtcccgct gtccaaaaca gcatcagcaa 3301141 aataaggcca gcgacaaggc attgcgcagc aaagtcccgc catcttgtaa agcgttgttt 3301201 tttccgttca agctcaaacc aatcacgttc ctctttttca taagcatcaa taaaagcatg 3301261 ccggcgtccg ctgaacatcc agtcgctgac acccatcaca gcatctgtca gacggctgta 3301321 cagcacattc cgtccgcttt tcagcttcgc attcttcgct ctcgtcacga gcaaagacac 3301381 aaccggaaac aatacaacaa gaacaaacaa atacagcgca agcaatatgg caaacggcca 3301441 agagaagaag ccgagcgcta tcactgacac agcatacagg agcaaggctg agatcgcagg 3301501 aaaaatcgtt tttaagaaag catcctgcaa atgctcaata tcctcagaca aaatgccgag 3301561 catatccccc gtgcgaaaac gggaacgcag catcaaagca cccggctcaa gcatattgta 3301621 aaggcggacg cgcatgtcag atacgatttt caaaatgatg tgatggccga cgagccgttc 3301681 cacatatcgc gacacagagc gcgcaatccc aaaggtgcgc acagcgacaa tcggcacata 3301741 aatgagcaga atgttttccg gccttgtcgc cgctttagaa atcaaaaaac ctgaggtgaa 3301801 catgagaaaa gcagcagaaa aaatcgtcac cgcacccaaa aagataacca gaacgaacag 3301861 gcgggcattt tgcttgatat acggcaaaat ccattcttct ttcttcatgc tctttccccc 3301921 agttgtgcct tcacgagttt ggtatacaca ccgtttttct ccagcagttc attgtgagtc 3301981 ccaatttccg caaccctgcc cccgtcaagc acgataattt cgtccatatc gagcatccag 3302041 tgaaggcggt gagtcgcgag aaagacgagc ttatcctcaa ataaatccag catcgtttct 3302101 tttatttcat attctgtttc gatatcaaga tgggcggtcg gctcatccag cagcaggatc 3302161 ggacggtttc ccaaaaaggc gcgggccagc gcgacacgct gtgcctggcc gccgctgagc 3302221 gcccggccgc cttccccgat ccgcccctct aatccgtcag gaaggttgtt caccagctcc 3302281 gtcagtcccg ctgaggcagc agcacgtgtt gtatcctctg ccgaagcgct tggatggtag 3302341 aagcgaatgt tgttgccaag cgtatcatca aaaatgtacg gatgctgggg aatgtaaaga 3302401 aggttcttct gccagctgcc gtcctgcaaa tgggaccggc ttgtaccatt aacctcaatc 3302461 atcccgccat ccggctctaa aaatccgccg agaatatcaa ttaatgttga ttttccggcg 3302521 ccgcttgcac cgataatgcc gatttttttc ttgcctttga atgagagatg aatatcagac 3302581 accgaacggc cgactgacac gcctgacagc ttcagctcat cctgatcgga ccaagcttcg 3302641 agctgaagcg gcgtctcttc tttaaaacca ggctgcgaca aaatctcttg aatggttttt 3302701 cctgcttcct ggccgttcag cgttgcatga taatcattcc ccacttcccg caccggcaaa 3302761 aaatactcag gcgccagaat aagcgccgtt aaagcagggc caagcaaaat atcgccgtca 3302821 atgaggcgca ggcccagaaa tactgcgact gtcgccaccg acagcatcgt gaaaaaatcg 3302881 agggcgaatg atgacaaaaa cgccacccgg agtgtgctca tcgttgcctt gcgataccgc 3302941 tcactcacat agaaaatatt tttgctgtgt gacttgctca aacctaggaa acgcaatgtc 3303001 tccagcccgc gaagagaatc aacaaaatga ttggaaagtc tctgatagga tttccactga 3303061 cgatccgctt ttctctgcgc gacaaggccg aggagaatca taaagatgat cagaatcggc 3303121 atagcagcga ctaaaatgat ggctgatgtc cgatcctgaa aaaacacata aatgacaact 3303181 gccgcaggca caatcgccat gctgaccatt ttcggcagaa acagctccag gtagcggcgg 3303241 aactggctga tgccttccat cgccagcgtc accatttgcc ccgtcccctc tttctttgca 3303301 aagcgggggc ctaatcggaa cagctgatca agaaaacttt tcctcaaatc tgctcctgtc 3303361 cgggcggcgt attgatagac gattttctgt cgcgccaccg tcatcccgtg ccgggcgata 3303421 aaagcgatga ggaaaaagcc gatcaccggt aaaagggagg taatgccctt cccgttgaac 3303481 agtccggtta cggcctcact cagccactct gcctgcataa taatggcggc tgtctgaatc 3303541 aacgttaaac aagtaatcaa ggtgagaatc cgcttcattc ctttatatcg aaacaggtct 3303601 tttcccatta ataagtcata ggctccttat ggctgacgcg cttccggaag acataatagc 3303661 tccagatctg gctgccgatg acgaacggca atagcgttaa tgctgcaatt gacatgactt 3303721 taagcgaata atctccagaa gaagcgttag ctactgttaa atcgtatgcg ctatgaagcg 3303781 agctgaccat tacacgaggg aatagggaaa taaagatcat tcccacggtc agcgccagac 3303841 cagcgcctgt catcccaaat gtccagccgt cttttttctt acgaataaat acagccgcga 3303901 gcataaagca gatgacaatc aaaacagcga gcggaatggt aatctcgccg cggcgtgtaa 3303961 acatgtctgt ctgatacgca gaaagggccg cgaaggcaag aaccgctaca aaaacaacac 3304021 ccattatctt ttgcgccatt ttccgggcgc ggttttgcaa atcaccaatc gtacgcagcg 3304081 tgataaacat taatccatgc tggaagcaaa gaagcgttac cgtcacaccg ccaagtatag 3304141 aatatacatt gatataatca gatacatgtg cgtgaatgtt catgtcggca tcaatcggca 3304201 tcccgcggaa taatgtcgtg aacagcacac caagcacaaa cggaggaatt agactgccga 3304261 aaaaaacgac ccagtcccaa acctttaccc attttaaatg atccaccttg ccgcggaact 3304321 caaacgcgac cccgcggccc attaacgcaa gcagcactat gacaaacgga atgtaataac 3304381 cgctcagcat cgttgcatac cagtttggga atgccgcgaa aatggcgcct gcgccagtca 3304441 aaagccacac ttcattcgcg tcccagaacg gcccgatcgt gttgatcagc actctgcgtt 3304501 ctaattcatt atggccaaga aaacgggtcg ccatgccgac cccgaaatca aagccttcca 3304561 aaaagaagaa tcctacaaac aatacagcaa cgagtataaa ccaaagatca tgaagagatg 3304621 ccatggtata cctcctgact aaatggatct gttgatacag gcacatcatg atgattatca 3304681 tgctccgcac cttttttaat ctcacggata aacaagaaga caagcagtgc accaagaatc 3304741 atgtacatca caccgaatgc gatgattgag aataacaagg aacccgctgt tacgttaggc 3304801 gacacagatt gagcggttgt cattaacccc ataaccgtcc aaggctgacg tccgatttct 3304861 gtcataatcc agcccgcgga gtttgcaaga aacgggaagg aaatcaacgc gatcatgatg 3304921 cgcaaatacc atttgctgtt ttcaagcttt ttacggcggt ttaaccaaag gccgcctaac 3304981 gcagcaagaa tcatgacaac acctgctcct accatgatgc ggaagctcca gaatgtcgtt 3305041 ttcactggcg gaatgtagtc gccttttccg tatatttttt cgtactcagc ctgaagggtt 3305101 ttcatccctt tgacacttcc gctgaatttc tgataagcca agtagctcaa ggcataagga 3305161 actttgattt catttgagct tttttcattt tttgtatcga tcgtcgcaaa agcggtccaa 3305221 gcagcagggt caccgctgtc ttcccatagg ccttcactgg cagccatttt catcggctgt 3305281 gattccatca agtgctcagc ctgcatgtgt ccgctaaggc cgacgccaag accggcacaa 3305341 agaccgacga tcattgcgag tttaaaagat tgcttaaaga acggcacttc ttttttcttc 3305401 agcagtttaa aagcactcac tccggcaata aagaaagctc cagtggcaag cgcaccgaaa 3305461 ataacgtgcg ggaattcaac ccaaagctga gggtttgtaa tcaacgcgcc aaaatcattc 3305521 atttccgcgc ggccgttttt gatcgtaaag ccgaccggct cctgcataaa ggagtttgct 3305581 gttaaaatcc agaaagatga catgatcgtt ccgaatgata cgagccatat gcagagcgcg 3305641 tgaattttct tcggcaggcg gtcccagcca aaaatccata atccgataaa aatagattcc 3305701 atgaaaaacg ccaataatgc ttcaatcgca agcggagcgc caaatacatc tccgacaaaa 3305761 cgggagtaat ctgaccagtt cagtccaaac tggaattctt gcaaaatccc cgttacaaca 3305821 ccgactgcga aatttattaa gaataagtgt ccccaaaact ttgccatttt gagatacagc 3305881 tcatttttct ttacaagata aagagtctcc atcaacgcaa ccataaacac aagcccgata 3305941 gacatcggca caaacaagaa gtgaaacaac gttgttgatg caaattgtat gcgggctaat 3306001 accaattcac tcatgctttc tcctccattt ccggttaaaa ctgttaattt gctcactact 3306061 tcacaaatag aaccgagact ttgatcagta attcacaaaa tagacgaaaa aaatattgct 3306121 caatatttca caaatgtgtc aaaaagtcat ccaatatgat gcaagattgc cagactgacc 3306181 aaatgacaca atctctgact ggttcatatt aagtacttta caacgattca tttcaaaaat 3306241 aaagcctaaa atacctaaaa agtcccgcac tatgtgacgg atttttgtct attttgttgc 3306301 ttatttatgt cggctgctag gataaatgac cctttattat cgtacatcaa cacatcgttc 3306361 cttgcgaaca aaatgcttgc ccccgcccca gcactcgagt ctcagcattc cgtcttaaac 3306421 cgattttagt cagaatgcct cttttcattt gaaccggtaa gaggagaaaa gttgaatagt 3306481 aaatttttaa tatattaata atttcaattt tttagtatac ttaacatagt gaacaatttc 3306541 actgcatcaa gaatagggga ggtttttcaa tgggagagct tcaaacacac atgcaattgc 3306601 aaacggatac aattcacgaa ggggttcgaa aagagaattg gtttgcgaaa gccatgaata 3306661 taaaagtagg catcataccg cttcctgtgt atgccttgct gtttatatta atcactgttt 3306721 ttgttatgca tcacgatgta aaaagtgaca ttttgacatc cattgccgtc atggcgtttt 3306781 tcgggtttac ctttgcccaa atcggcaaat cgataccgat tgttcgttct atcggcggcc 3306841 cggccatcct agctactttt attccgtccg ctgtcgtgta ctatcacctg ctgcctaatg 3306901 atatcgtcaa atccaccaca gaatttacag aaaactcaaa ctttctatat ttgtttatcg 3306961 ccggtattgt cgtcggaagc attctcggca tgaaaagaga aacactcgta aaagcattca 3307021 tgaaaatctt tattccgctt attgtcggtt ctgtcacagc cgctattgtc ggactggctg 3307081 tcgggacatt gctcggactc ggatttcagc ataccctgct gtacattgtc attccgatca 3307141 tggctggagg agtcggagaa ggcgctatcc cgctgtccat cggatattct gacatcatgc 3307201 ccatttctca aggggaagcg tttgcacttg ttctgccatc gattatgctg ggcagcttgt 3307261 gcgcgattat tctagcggga ttgctgaacc gaatcggaaa gaaaaaaccg gaatggacag 3307321 gcaacggcaa agtggaccgc tccgaagaag agtcccctgc gctggaggaa tctcaaagcg 3307381 gacagcaaat gttcaacctt tctttatttg cgtcaggcgg tatccttgct gtttctttat 3307441 acttagtcgg catgctcgct cacgattttt tcggttttcc ggcacccgtt gccatgctgt 3307501 tactggctgt tctaatcaag ctgttcagat tggtgcctgc ctcaattgaa aatggcgcgt 3307561 ttggagtgtc ccgcttcttt tcaacagctg tgacctaccc gcttctcttt gcgattgggg 3307621 tatccatgac gccgtgggac aagcttgtcg ccgcttttaa cctcagcaat attatcacga 3307681 ttctgtctgt cgttgtgacc atgatggccg ttggcttctt cactggaaaa tggctgaaca 3307741 tgtatccgat tgaaaccgcc attattaatg catgccattc tgggcaaggc ggcacgggtg 3307801 acgttgccat tttaagcgcc gctgaaaggc ttgagctaat gcctttcgcc caggtgtcta 3307861 cccgcatcgg gggcgcgatt acagtatcct taaccttatt gctgctgcac cagttttatt 3307921 gatccccgca agcaagttct tcgtcaaacg aaagagcttg cttttttgca tgtccatgtt 3307981 tttgcaagtt cccatcccat gctatagtaa tagttggaaa tactagatag aaaggaatct 3308041 ggcatgccta tgggaactca tctatttctc tttatgcttc tcgggctggg attttatttg 3308101 atatcagccc tagctgcaaa actcattccg gccatagact tctggattga tattgttcta 3308161 tgggtcggcg ctgcggctta catcttctct catctctcat tcatggacgg cattgtctca 3308221 ctcgcgacaa tgttctactg ctattggacc gcaatggatc tcattgtttc agagcgtgtg 3308281 gaaaaacctt cgggagactg gcaggaaatc gagcttgcca aaaacaaaac acgcctcctg 3308341 tcagacatta cgctgaccgc cattgtgttt gcaggggctg tcattttttt catctatgga 3308401 cctgacacaa gccctctcaa atatgtgatc cttctcggaa tgatctccgg cggaggggca 3308461 cttgtgaagc gaatactgaa tgtttttagc gtaaaggttt tttattcagc agccttagaa 3308521 aaattgcata tcagctcaca ctatgaaacc cgtacatacc cgctttccga tttgaagaac 3308581 attcagcttg aatcaacagc agatctctta aagctccatc cgcttctgac gatgtattca 3308641 tcccgtttag atttgacaac aagctttcag caagtcatta aactgtctct tcccggcgaa 3308701 acactgtttc tgacggtgaa ggaaccgcaa aaatggaaaa caattcttca ggaatacaca 3308761 gatgcagaaa acaatgtgga caatgtgatt tctgttttgc cgttttatca tcgaaaaaat 3308821 gtgaagcggc tgctcggtaa gctttatttt gccgccagcg taaaaggggt atccgcttac 3308881 gccttattgg tgctcgcgtt atacgcatta cacgcctctc catgggtcat ggctgttgcc 3308941 gtaatcctat attgggtatt caacatgtat atgtcagacc gtgtgttgcg ggcggcgatg 3309001 gacgccaagt cttgtcatca tccgcatgta caggccgcgg ccgataagat tttcagatcg 3309061 gccggcattt cccatgtccg catatacgaa acggagagtg atgattacaa cggaatggca 3309121 gtaggcatga atgtcgggag gtcaatggtc atcctgacaa gcgccacact aacacttcca 3309181 cagcgtgtca ttgaaggcat tctggcccat gaggcgattc atatcaaaaa acgtgacgtt 3309241 ctgtcatcac agcttttgcg ttttctatat cttggagctg tcgtggggat tttcctcttg 3309301 tttgagcagc atatcaccca tcccgaggcc cacaaaattg cgctttgggc tttcattatg 3309361 gcaatcatta tcctattcca gctctatcaa tccttttgtt cacaatggat ggaggtgcgt 3309421 gctgacaacc ttggcgcatc attgctggac ggcggttaca aacaaatggc tgaagccttg 3309481 agaatcttgg cggttcggca agatgaggat atacagaaac aaagtgccta tagctctgaa 3309541 gcaggtgaag acgagcttca aattgattct ctcacccgtg ataaaagctg gtttttcaga 3309601 ttgattgatt ttcagttcgc tcctcatcct cctatgtatt ggcgtgtcgg cactttattg 3309661 tcaaacaaag gacatggggt gctaaagcgc tggctcagag accgactgaa agaatcgatc 3309721 actttgaaat gaaaccggtc agcgtttcat ccgtataaca gatatggtga aaaaagggag 3309781 tgacgcgaag tgattgtgat catcttattg tttatatcta ttattgtttt tctttcagtc 3309841 attcagccgc agccctcgaa aaacaaaagc cgccagcagg cggacagcgg gtatttcggt 3309901 tattcagatc atagctcaca ccatgatgga tgcagcagtg acggaggttt cagcgattcc 3309961 ggctgtggcg gcggaggggg cggcgattaa acgccgcctt tttttatttc attgattcga 3310021 tgtacgcacc aaaagccgag cctgacatgc ctggggacac gcgcacacga tggagggcat 3310081 acattccctg gtctctcgaa gccgcgcccg gttctgtcgt cacgcccatt tgatagcctg 3310141 ttttttcagc ggccttcagc gtctcctcat tgtagcgccc taccggatag ctgatgatgg 3310201 tggtttgctg atgaaacatg ttgtcgaaca gctttttcga atcagccatc tcactttgct 3310261 gctgttgagg cgttaatccg ttcagctcaa ggtggtcaat cgtatggctt tcaatcgata 3310321 tgccgtgctg tgccatttcc ttcatttgtt cctctgtcag atggtgctta tgtccgatcg 3310381 atttgccgat cataaaaatc gttgccttca tcccgtactt tttcagcacc ggatacgcat 3310441 cttgataatt gtcggtgtac ccgtcatcaa atgtgatcag cacgcacttc tcactcggtt 3310501 ttttatcctg cgtcagcatg agagatgcct ctttcggcgt taatgtctga tagccgttat 3310561 catgaagcca cttcatatgc gcctcgaatt ctttctttgg cacacggagg ctgtttcctg 3310621 aagaaatgct gtggtacatc aaaatcggca gctttgccgg tttctctgtt ttgatccatg 3310681 cggatgtatc gtcttctttt ttctgaactt gtactgcctt tttttccggt ttcttttgtt 3310741 ccgcttttgg catcggctgc tctgcattcg cctcttgatc agcacaagcc gcaagagcca 3310801 aacagctgcc caaaagaaag atgcttaaaa acaatcgttt catcgttctc ctgctttctg 3310861 tctatttctt cctccttttt catcggtttg attctgagat tttcaatagc aaaaaaccgg 3310921 acatgtctcc atgtccggtt tttttgatct tatcggattc tcacttctgt ctcactgtca 3310981 aagaaatggc ctttattcat atcaaatgca accgtcagct catcgcccga ttgaatatcg 3311041 aggcgggcgt cgatccgcgc aataaagtct tggttgtcta tctgcgaata aatcataatt 3311101 tcagaaccga gcagctctgc aacattaatt ttcgccttaa tcgaagagtt cttatatgat 3311161 tccacgacaa tcaattcatc atgtatatcc tcaggacgga tgccgaagat gacctctttg 3311221 ccgatgtagc ctttttcacg cagcactttc atttttcctt ccgggacggt taatgccgca 3311281 gaaccgattt tgattaagcc atccgtgagc tttcctttga aaaaattcat cgccggtgat 3311341 ccgataaacc cgccgacaaa gacgttttca gggaattcat atacatcctt cggcgtcccg 3311401 atctgctgaa ttttcccatc tttcatgact acaatccgtg tcgccattgt cagcgcttct 3311461 gtctggtcat gcgtcacata aatcgttgta gtctgcaatc tctggtggag cttaatgatt 3311521 tccgcccgca tttgcaccct cagcttcgcg tccaggtttg acaaaggctc atccatcagg 3311581 aacacctttg catcccgcac gattgcccgg cccagcgcaa cccgctgtct ctgtccgcct 3311641 gacagcgctt tcggtttacg gtgcaaatat tcctcaagcc cgagaatttt agcggcttct 3311701 tcgactcttt ttttgatttc aggcttcggc attttccgaa gcttgagccc gaacgcgata 3311761 ttatcgtaga ccgtcatatg cggataaagc gcgtagttct gaaataccat cgcgatatcc 3311821 ctgtcctttg gcgctacatc attgacccgt tttccttcaa tataaaaatc acctttcgaa 3311881 atttcttcaa gtcctgcgac cattcgcagc gtcgttgatt tcccgcagcc ggacgggccg 3311941 acgaatacga taaattcctt atcggcaata tgaaggttaa agtcatcaac cgccggttcc 3312001 ttctgatcat aaaatttata aatgtgctcc atccgcaatt cagccatcta acatccccct 3312061 ttgttattgt aaacgctttc ttatattgag tgtaacagca attccctctc gctaaaatgg 3312121 gcagcgttca taaaatcacc cagccatttt tcgtgcatat ttccaattta ttctgaactt 3312181 tcattttgca ggcagataaa ataggcaaga agcgcgcctt tgtacgattt gatatctatc 3312241 cctgaccgct caataaattt atcaatccga tattgcaggc tgttgcgatg cagatgcagc 3312301 tttttcgctg ttaatgtgac gtttgagttg ttttcaataa acagcttaat ggtcttcctt 3312361 agctcagatt cacttccaaa taaaagctca gcttcttcag agagcagtgt ttccagtttt 3312421 tctttttctg tttctaataa tagaaaagga aagatcatct caaaggtcac actctgcacc 3312481 tgaggcagcc gtttttcagc aaacaggaaa tacgcctgtt cacgagcgta atgttttcgc 3312541 agacactcat ccggctcgta aaatcttccg gcgtaaaaac ggacactgaa gtagaaatca 3312601 ctttcaagaa ccttagcgag cgattccagt tcgtccttct ccgccgccgc ttcactttcc 3312661 tgctcgacaa tcacacctct gtcctcatgg atccacacaa tcacaaaaga caccggccaa 3312721 aaatggcgaa ccgcttccgt aaaggacgtc ctttctattt tgccgaataa atgaaagtga 3312781 acaaatctcg tccgtttctt tatatacgcc ggcaattccc ctctggaaaa aaggaacgaa 3312841 aaccacttgt tttcctcagg tgatttcata gacagttgat tgccctcatc cgcaggcgtc 3312901 aaaaatgact gcagcaccaa tacttctttt tcactgatct ctgttttcgg aatggagata 3312961 tatctctgat tgctctcatc aaaaaaacat agacagcctt cccttatgca aagctcctca 3313021 gacacaatcg aaccgggata aatagccagc agcgatttca tagagtctcc tctcttatgt 3313081 aaggatctgt atattcagta taaggcgaaa cacacatgtt ctccactaaa aaagagtata 3313141 tccggtatag atagacgaga aactgaaagg gaaacctcat tcgtttacat attggcttca 3313201 gcggaaatag aagaagacat gcaggaccaa aggagggtca tcttatgagt ttcgaaacgt 3313261 taaacaaaag ttttatcaac ggaaaatgga ctgggggaga aagcggacgt acggaggaca 3313321 ttttgaatcc gtatgaccag tctgtgatca caacagcatc tttggcaacg ggcaaacagc 3313381 ttgaggatgc gtttgacatt gcacagaaag cccaaaaaga gtgggccaag agcacgacgg 3313441 aagaccgaaa agccgtgctg caaaaagcgc gcggctattt acacgaaaac cgtgatgaca 3313501 tcattatgat gatcgcccgc gaaactggcg gaacgatcat taaatcaaca atcgagctgg 3313561 aacaaacgat tgcgatttta gatgaagcca tgacgtatac tggtgaatta ggcggcgtca 3313621 aagaggtgcc atccgacatt gaagggaaaa ccaataagat ttaccgcctt ccgctaggtg 3313681 tcatttcatc gatttctcca tttaatttcc caatgaatct atccatgaga tccattgcgc 3313741 ccgcaattgc gctgggtaac agcgttgttc acaagcctga tatccaaact gctatttccg 3313801 gcgggaccat cattgcgaaa gcgtttgaac acgccggtct tcctgccggt gtccttaacg 3313861 tcatgctgac ggatgtaaag gaaatcgggg acggcatgct caccaatcca atcccgagat 3313921 taatcagctt tacagggtca acagcagtcg ggcgccacat cggtgaaatc gccggtcgcg 3313981 ccttcaaacg aatggcactt gagctcggcg gcaacaatcc atttgccgtt ctttcagatg 3314041 cggatgtcga tcgtgctgtg gatgccgcga ttttcggaaa atttattcac cagggacaaa 3314101 tctgtatgat tatcaacagg atcatcgttc atcaagatgt atacgatgag tttgtagaaa 3314161 aattcaccgc ccgtgtcaaa cagcttccgt acggcgatca aaccgatccg aaaaccgttg 3314221 tcggcccgct gatcaacgag cgccaaatcg agaaagcgct ggagatcatt gagcaggcaa 3314281 agacagacgg cattgagctt gcggttgaag gaaaacgcgt cggaaacgtg ctgacgccgt 3314341 acgtctttgt cggtgcggac aacaacagca aaattgccca aacggagctg tttgccccaa 3314401 tcgcaaccat tattaaagct ggcagcgacc aggaagcgat tgacatggca aatgatactg 3314461 aatacggcct cagctctgcg gttttcactt ctgatttaga aaaaggcgaa aagttcgccc 3314521 tgcaaattga cagcggcatg acccatgtca acgaccagtc cgtcaatgat tcgccgaata 3314581 ttgcctttgg cggaaacaaa gcaagcggtg tcggccgttt cggcaatccg tgggtcgtcg 3314641 aggaatttac cgtgacgaaa tggatttcga tacagaagca ataccgcaaa tatccgttct 3314701 aaatgaaaaa atccctctgt ttcaagtaca gagggatttt tctttattta gatatatcca 3314761 caaacccttc gccaaacaca tcgcgtacgt catgtacgat cacaaacgct tttttgtcgc 3314821 agcttctaat gatttttttc agcatagaca gctcctgttt gttaatgacg atatacaaaa 3314881 tctcttttga ctggcccgta taatttccct tccctgataa aatcgtcacg ccccgatcca 3314941 tcaaggtatt tacctgctct gcaatctcac tcttattttc tgaaatgacc gtaatggctt 3315001 ttttcgtatt caaaccttca ataatgaagt ccatcacttt ggtaccgata tacagcatca 3315061 cgatcgtaaa catcattttt tctgcaccaa taataaaata agagctaaat actacgatta 3315121 aatcaaaaaa caagagtgca tagctgatat tccagtctaa atatttatta gcaattctgg 3315181 ccagaatcgc ggaaccggcc gtcgtcccgc cgacccggat aatcatgccg atcccgactc 3315241 cggcaaatac acctgcgaaa atcgtattaa tgatcaattc atcagacgga atgctccacc 3315301 catgtgtcag atgaagaaaa agcgaatttg ccgcaaccgc aatgatcgta taaaccgttg 3315361 tttttccatc aagaaacttg tagccgatta aaagcaaaaa cgcatttaag ataaagttcg 3315421 tgacaccagg agaccattga aacagataat acaaaatcag cgtaatccca gtgactccgc 3315481 cttccccaag atcattggga atcgcaaata aattaaccgc aagcgcgaag aaaaaagcgc 3315541 caatcacaag cataagtaca tccagcattc tctttttcat cacgaaaaca ctccttttca 3315601 ttgttctgtt ctagcaaata aaaaaaccca ggagaacgct ctcgaaaaag agcagaaact 3315661 cctgggcttt tatcccaccg tgtcataaca gccaagctgc tatgtgtttt ctctcggtca 3315721 cagtccaatt tgcattgcgg aaccctagaa aaccactgtt tttatcatat ccttttcact 3315781 ttccaatatt agcattataa gggacggttc gaattggttc aaggggtatt tgcggagttt 3315841 tcatcagata agctggaaaa aaatacgatt tatctattaa aaaagaacag atataaccga 3315901 taagaaaaaa agcatatatt ttacaagcga atgtaactat aaatgataat aattataaga 3315961 aattcataat tttatattga ctaagagaaa taatataggc attatagtac atatgtttcg 3316021 tacattttat tacataggag gaaatataat ggcaggaaaa ctagtaccct gtaaagcttg 3316081 cggtcaagaa attgcaaagg gtgtaaaaaa atgtcctaac tgcggtaagg atcaacgtaa 3316141 cttttttatg cgacataaaa tcattacgtt tattctcgca gttgttgtca tcattattat 3316201 cggtaatatg attggcggcg gaggcggctc agaagccact tccaaaacat caagcagcag 3316261 caaagcagaa actgaaaaaa catacaatat cggtgatacc gtaaaaactg aaaaaactga 3316321 agtgacggtt acgaaggtag aggacagaga tactgtcggt actcaatatg ttgaaaagaa 3316381 agcatctgag ggaggtacaa ttgtagctgt tcaatataca attaaaaacg tatctaaaaa 3316441 gccgattagc tctttttcaa ttccaactgt taaattagtt gatgctgatg gtacttctta 3316501 tgattctgat attgatgctt ctgtaaacta tgcaactgag acaaaagttg ataactctaa 3316561 aattttgagt gatctaaatc ctaatattaa agtaacaggt gtaaaagcat ttgaagttga 3316621 caaggaagct tatgcaaaag gcacttggaa actaaaattc agtaatgatg ttattgtgaa 3316681 aatcaaataa cagctaacaa gggtgcctgt ttaggcaccc ttgttcttta aaaaaggcct 3316741 tctcaattga gaaggcctcc attcttattc cgcactctta tacccattca cattagaaga 3316801 ctgccatctc caggaatcag cacacatttc ctcaaggccg cgtttcgctt cccagcctag 3316861 ttctcgcttg gctttcgcag gatctgcaaa gcatgtggcg atgtctcccg gacggcggtc 3316921 cgcaaaacgg tatggaacct ctttccctga cactttttca aaggctttga ccatttccag 3316981 cacgctgtag cctgtgcctg ttccaaggtt gtatgcatcg gctcctgtag agttcaatac 3317041 tttttccagc gccttgacgt ggccttctgc gagatcaacg acgtgaatat aatcgcgtac 3317101 gcctgtcccg tcttttgtcg gatagtcatt tccgaatacg cttaattgct cgagcttccc 3317161 gactgctacc tgtgccacat acggcataag gttatttggg attccgttcg ggtcttcacc 3317221 gatccgtccg cttggatgcg cgccgaacgg gttaaagtaa cgaagcagcg caacgctcca 3317281 ctcattgtcg gctgtatgca aatcacgcaa tatttgttca agcatgagct tcgtctgccc 3317341 ataaggattt gtcgcgccta atggaaagtc ttccgtaatc ggcgatgttt ccggaacgcc 3317401 gtatactgtc gcagatgaac tgaatacgat tttcttgacg ccgtatttct ccatggcctc 3317461 gcataaaata aacgttcctg tcaaattgtt atgataatat ttgaggggaa tcgccacaga 3317521 ttcgccgact gcttttaacc ctgcaaaatg aatcacagct tcgatttcat tttcagcaaa 3317581 aacggaatct accgcttccc ggtccaataa atccgcttcg tagaacgtta aatcttttcc 3317641 tgtaatctcc ttgacacggt tcagcgcttc agctgaactg ttggacagat tatcaagaac 3317701 aacaatctcg tagccgctgt tcaatagttc aacacatgtg tggctgccaa tgtaaccggc 3317761 accgccagta acaagtattg ccatgatgta aaccctccta aaaaatgacc tgttttcatt 3317821 atatagtgtt tagaaccggt ccacatccat ttttaagaag tttaatcgtt tattaatagt 3317881 tttttcatat tttttagctt aaacccttgc cagcaattcg atagaggttt cagcaagaat 3317941 gtgctctttc atttcttgat agagctcatt caagtaaaag cccggctgaa gattcagctc 3318001 agcatctaaa gcatagaccg tcaatgtata cgcatgatcc ttgtcaggcg gtgtcggccc 3318061 gcaatactgg tgaatcacct ttggatcgtt gcttcccgca agcggtgaag caaagctgtt 3318121 ttgcccttgt atcatcaagt cctgtctttc ctcactcgca tgttcaggaa gctctccgat 3318181 gtaagccgga atattagccg ctgtccagtg aatccagctg aatccgcata cgggaatggc 3318241 gtcatgatcg atgaaagtaa gtgcgagcgt ctttgctccg gacgggatgt catcaaaatg 3318301 aattggaaag gatacaaatg ggtttccttc tctcttatat ttttcatccg cgtattttga 3318361 atacttgtca tgtaaatatg gatttgcttc tacgtatatg ttcatatgaa tccctctctc 3318421 tattttctcg ttctataggt atactaaacg aatcgatgta taatcagtga taaacaaata 3318481 cgcatgtaaa cgtaacaatt tgttatggat aacttgcagt gaaggagata tttcatggat 3318541 ttaaaatggc tgcaaacctt tattgccgca gcggaatcag agagcttcag ggaggcggct 3318601 gagcatctgt atctcacaca gcctgccgtt tctcagcata tgaggaaatt ggaagatgaa 3318661 ctggacatga ggttgttttt gcatagcgga agacgagtcg tactgactga cgaaggcagg 3318721 ctctttttgc cttatgccaa agaaatgatc catgtttacc aagctggaaa gcagaaagtc 3318781 agtcaatgga aacaggggta cagccgatca ctcacgctgg ccgtacaccc ctacattgcg 3318841 tcctatatct tgcctcgctt tctgccagcc tatatccaaa aacatccgca tgtcgagctt 3318901 tcaactcatg tggctggatc tgacgctatt aaacaagcgg tggaacacaa tgaagctgat 3318961 attggtttgt cgcggaaaga cccgaacacc aacactcttt attatcagca tatatgcgaa 3319021 ggtacgcttt gtctggcggc tcctttccaa gaaagcagac cggatgctgc atccgtctta 3319081 acccgctatc ggctgctaac gcatgatcat ccgtcatatg gggatgcctt tttagataac 3319141 atccgatcac attacccgta tcttcaaatg atggctgtcg ggcagacgga tacggctgtc 3319201 cacatgatga aagcgggaat gggggcatct ttcctcccta cctacattat caaacaggaa 3319261 gaagccgaaa aaaagctgat ggctgtcagc acgcctgcac atctagaatt gcctgcgtcc 3319321 caaacgttta tgatgtggaa aagaaacagc gaagacattc agcattttca cgccatgtta 3319381 catgacttta tgcagcgcga acaagtatag agctgaaaaa tcaatctgcc ggttgacgtt 3319441 tttctttcct attttcgcta tgcttaatgc agaaaggatt tgatgacatg gcgatgagcc 3319501 cttatatttt tattgtattg attcttatta ttttatcgat gtatcgagaa agaacggtaa 3319561 agcccgggaa gttgctgatc attccactgt tgctcttatg gggcgtatct gcatcgtttc 3319621 agccggcgta ttttcattcc gtattacatg tggcgatcag cggcatttta ttactgatcg 3319681 ggctggcctg cgggtttggc attgggaaga tggtaaatgt acggattcac ccggaaaccg 3319741 gaaaggtcac ttcacgcggc tcacttggga gtgttatcct cattctagtg atactttctt 3319801 tgcgcatggc cgcgagaaca tggctgcctg agagcaacga gatgtttatt gccattattc 3319861 attctatgtt cttcgttccc ctcggcacca tcacagcccg caacatcatg ctttacaaag 3319921 catacagacg actgaccgct ggcaaagtat ccattcaata accgaaagaa ggaccagcat 3319981 gaacggacaa actccggctc ggcactacta caagaagctt gtgccgagcc ttattctcat 3320041 tttgaattgc atacaatttt tatctcatcc aactaaggct gatcccattt tgttagcatt 3320101 tgtatttgcg gtatacttag cattcatttg gatcattccc tatgtggcat ccactgctgt 3320161 tagtttgagc atattcatcg gactctggct cctgaccgat ttcttttggg ctgtttccgg 3320221 ccaagagcag ggtgccgcct attttttgat tgtattttta atgatatatg ccgcctttag 3320281 actcccttca cggctatcct tgatcttcac agcatgttta attggaggca acatattact 3320341 cctatcctca caagggggaa gcttgaatac catcatcagc aacatctcga tcatgctcgg 3320401 tctgtacgtc ctcttctcct ccatgcgttt cagacgagaa gcgagaaggg aggctgaacg 3320461 gaatcatgct gaattggcaa aaatgcatgt gcagctggag catgctcata aagaactcca 3320521 gaaagcgcat gcagagctgc aggaggcttc tgttctttca ttaaggtacg cggtccttga 3320581 ggaacgtaca agaattgccc gcgacattca tgacagcatc ggtcacgagc tgacttctgt 3320641 gattgttcag cttcaatccc ttccctatat ccttaaaagc agcaaggagg attcagaaaa 3320701 agtcattcaa aatgtactga gtgtcgccag ggagtgtctt caagaagtgc ggtctgttgt 3320761 tcaccaaatg ggccgtagtg aatcgatggt ggggcttacc gctttgcggg ggctcattca 3320821 tcaagtggag gaacggagcg gcttgcacgt ttctttagat actgccggac tgtcagaaga 3320881 gtcttggcct ccaaacgtga gcgaaacgat ctaccgcatc ttgcaggaag cgctgaccaa 3320941 tatcattcgt cacgctgacg cttctcatgc ggcggccgtc atttctaatg acaagtccca 3321001 tctctatgtc acaatcaccg acgacggaca attcaccggc agccttactt atggatttgg 3321061 cctgacagga atgaaagagc gcgcagaaaa agcaggcggt tcccttactt tcagtgccgt 3321121 acagccgagc ggcctgaaaa ttgagctgtc attgccgctc atgacaacga ataaggagca 3321181 aaaagatgaa caaagataaa atacgcgtag cgcttgccga tgatcagccg cttgtgcgtg 3321241 aaggcttccg ctacgtcatc aacgcacaga cggatatgac ggtttctggc gaggccggcg 3321301 acggtcacga tattatagca ctcgcaaaac aaacaaaacc cgatgtcatc ctcatggatg 3321361 tccagatgcc gcgttgctca ggcatcgaag cggcgaaaga cattatgtcc gcacttccaa 3321421 atacaaagat agtcatttta accacctttg acacggaaga atacgtattt gaaggcatcc 3321481 gtgcgggcgc agtcggctat ctgctgaagg atacacttcc tgaggagttg atagatgcga 3321541 ttcgcgctgc ggccagaggc gaggcgattt tccgtacagt cacagctgct aaaatcatca 3321601 gtgagacatt tcgggcgaaa cagcaaactc atgccgaaga actggcagag ccgttcacca 3321661 aaagagagct tgaggttctt cagcaaatgg cctacggact gagaaatgag gatattgctg 3321721 aaaagctttt cgtcagtgaa agcactgtga aaacccacgt gcaccgcatc ctgcaaaaat 3321781 gcaatgccca agaccggaca caggcagtcg tttttgccat tcgaaacggt attgtgcaat 3321841 agaaatctct catcccgcca tgctaaaata agacaaagga gatgattgga aatgaaagaa 3321901 gaaatcattg aacggtttac tacatatgta aaagtcgata cacagtccga tgaatccgtt 3321961 gacacttgtc cttccacacc cggccaattg acattaggaa acatgctagt tgatgaattg 3322021 aagtccatcg gcatgcagga tgcagccatt gatgaaaacg gctatgtcat ggcaactctt 3322081 ccctccaata ctgaaaaaga cgtgccgaca atcggctttc tcgctcacgt cgacaccgct 3322141 acagacttta ccggcaaaaa tgtgaatccg caaatcatcg aaagctatga tggaaaagac 3322201 atcgttctta acgaacagct gcaggtcacc ctgtcacctg atcaattccc tgagctgtcc 3322261 ggctataagg gccatacact catcaccaca gacggcacca cccttctcgg cgcagacaat 3322321 aaggccggta tcgctgaaat catgacagcc atggattacc tcatcaaaca ccctgaaatc 3322381 aagcacggca caatcagagt cgcctttacg cctgatgaag aaatcggaag agggccgcac 3322441 aaatttgatg tgaaacggtt caatgcatcc tttgcctaca cggttgacgg cgggccgctc 3322501 ggcgagcttg aatatgaaag cttcaatgcc gctgccgcaa aaattacgat taaaggcaac 3322561 aacgtacatc ccggaacagc taaaggaaaa atgatcaact ctgcgaaaat cgcgatgaag 3322621 ctgaacagcc tgctgccggc agacgaagcg cctgaatata cggaaggtta tgaaggcttc 3322681 taccacctgc tgtcgattca aggagacgta gaggaaacaa agctccacta cattatcaga 3322741 gactttgaca aagagaattt ccaaaacaga aaagaaacaa tgaagcgtgc cgttgaagaa 3322801 cttcaaaacg aatacgggca agaccggatt ctgctggata tgaacgacca atactacaac 3322861 atgagagaga aaattgaacc tgtcatcgaa atcgtcaaca ttgccaagca agcgatggaa 3322921 aacctcggca tcgaaccgaa gatttccccc atccgcggcg gaaccgacgg atcacagctg 3322981 tcctacatgg ggcttccgac gccaaacatc tttacaggcg gggaaaactt ccacggcaaa 3323041 tttgaataca tctcagttga caacatggtc aaagccgtaa atgtcatcgt tgagattgca 3323101 aagcagtttg aagcgcaagc ataacgccaa aagccagtcc aaaaaaggac tggctttttt 3323161 gtgtgaaaat gaaacatttt aaacacgtcc tccgtaaaac aagtatcaac aaatgaggag 3323221 gaaaaacaat gacaaaacat gcaatcgctg ccaagagtct cttgaaaaaa tggatcattt 3323281 ccaggccgct taacatgaaa aagaaatcca gcccatttca aaaaatcaga aaaatgttca 3323341 aacgcttctt caaataaaac atcaaatccc ctaaatacaa tccgtattca cccgtaccgc 3323401 ccaaatgctc cgtaatttgg gttttttgtg ttcaattccg caaaataggg tataaaccaa 3323461 acaagcaaga aaacagcacc caaaaacagg taattcgaat tacgtaaact taggttaaaa 3323521 gttatataaa ggaatttatt ttatcgtcga tagtaactat agaaccaatc atcaacaaga 3323581 gcaaacagcg taattcaaga ctattttcag gtcatcaggt aatactgttt tagagggaca 3323641 gtttcttgtt atttattgat ttagaatttt ttgaatactt tttggcattt tatccgtaca 3323701 atagagagta ccaaaacttt ttttgggagg tatgtaatat gatcctattt attatcatcg 3323761 cattatgcgg ctatcttctt ttttctttca gcaaggacaa tcgccgcaaa ccgcaaaaga 3323821 caagccctct gccagcagcc gcacctcatc acaacaacct aatcgacctt gacgccatcc 3323881 gccaaaaacg ccggatgcat ctttcctaat tctatatttc aaacgaaaag gctgctgaat 3323941 cacgcagcct tttaaaattg ttttgattta gagcctgaaa ccttttcgcc acctatccgt 3324001 aatttcatac aaggcaaacc caaaggagac ttcagcaatg atcgagttat ttatgaaaca 3324061 aaaaatgttc tcatttaaag atgcatttca catttatgac cgggatgaac aagaaacatt 3324121 caaggtggag gggcgttttt tctcgttagg agactcatta caaatgacag actcatctgg 3324181 gaaaacgctc gtttccatag aacaaaaact aatgtcttta ttgccgcgct atgagatttc 3324241 aattggcggg aaaacagttt gtgaggtaac gaagaaagta acgttttcca aaccgaaatt 3324301 tgtgatttcc gggcttaact gggaaataga tggtgattta tggagggatg aattccaact 3324361 gacggacggg gaaaatgtcc ggatgtcagt gagcaaaaag tggctcagtt ggggtgattc 3324421 ctatcacttg cagattgcat acgaggaaga tgttctgatt tgcactgcca tcgctatcgt 3324481 gcttgatatg gttttatata acgatgaaga tgaaagtatt ttctaaaaag cattgacaat 3324541 tgatccaaaa gtaataatat taagataatt gaaatctgaa tatgaagttg taccttatca 3324601 agagaggtgg agggactggc cctatgatac ccggcaaccg ctgtttcaaa cagaatggtg 3324661 ctaaatcctt aagaacattg cgttcttgca gatgaggcgg agatttgatc gttcaagctc 3324721 ttccttacac aaaggaagag ctttttacat gcttaatatt tcagaaaaga ggcgaataac 3324781 atggctcaac aaacgaatgt tgcaggacaa aaaacagaaa aacaacgcaa agcacctttc 3324841 cgcgccgatc atgtcggcag cttgcttcgt tccgttccgg taaaggaagc ccggcaaaaa 3324901 aaagcggctg gtgagatgac agcggaacag cttcgtgata tcgaaaatca agagatcacc 3324961 cgcatcgtgg aaaaacaaaa agaaatcggt ctcgatgtgg taacagacgg ggaattccgg 3325021 cgttcctggt ggcattatga cttcctggaa gggcttgacg gtgtggaacc gttcatcccg 3325081 gctgagggga ttcagttcca taacacaaaa acgaaagcgc gcagcatcaa agtgacggga 3325141 aaactcgatt ttacgagcca cccagcgctc ggtgattatc aatttttaca tgagattgcc 3325201 ggtaacgcga cgccaaaatt gaccattccc agtccaaata tgctgttttt tggcgaaaag 3325261 gcggataaag ggatttatga cgatcaagag gaatactttc atgatatggc ccaagcgtac 3325321 aaaaaagcaa tcaaagcctt ctatgatgct ggctgccgtt atctccagct tgatgatacg 3325381 tcatggtctc tcttctttga ggacaaaggc agagaggttg tccgggcgct cggcggtgat 3325441 ccagaaacat tgccagccat atttgccaaa acaattaacg atgccgtcgc agaccggcct 3325501 gacgatttaa cgatcacaat gcacatttgc cgcggcaact tccgctcaac ctgggcggca 3325561 tcaggagggt acgacgctgt agcggaaacg attttggacg gcttaaacct tgacggcctt 3325621 ttcttggaat acgatgatga ccgctccgga aactttgatc cgctccgttt tgtgaagcgc 3325681 aaggatctgc aaattgtgct cggcttgatc acatcgaaat acggcgagct tgaaaatcct 3325741 gaggatgtga aacgccgtat caatgaagcc gcgcgttttg tcagcttgga ccagctatgc 3325801 ctgagcccgc agtgcggttt cgcctctaca gaagaaggca accttctgac agaggagcag 3325861 caatgggcaa agctgcgcca tgtcatcgac attgccaacg atgtgtggag ataatctatc 3325921 attgacagaa atagaaaatg tgtgaataat agatactatc agaaaattta ataaaaaggt 3325981 tttccttatc aagagaggtg gagggactgg ccctgcgata cccggcaacc gctgtttaac 3326041 agaatggtgc taaatccttt agagcaatga ttgctcttga agataaggtt gagattgtca 3326101 cgcaagctct tccttatcca aaggaagagc ttttttatat ttgaatggaa agaaggaatg 3326161 gacaacatgt cacaacaaac aacacccgca gaacaaaaat cacttcaaag aaaaaaaccg 3326221 ccgtttcgcg cggatcaagt cggaagcctg ctaagatctg agcccgtcaa aaaagcgcgg 3326281 ctgcaaaaag cggccggcga aatgaccgct gagcagcttc gccaaattga aaacgacgaa 3326341 atcatccgca ttgtggaaaa acagaaggaa accggcctga acgtcgtgac agacggtgaa 3326401 ttccgcagag catggtggca ctttgatttc ctggaaaact tagatggcgt tgagccgttt 3326461 actcctgagc aaggcattca attccataac gtacagacaa aagcacgcgg cattaaagtc 3326521 acaggcgata tcgacttttc aactcaccca atgcttgaag attactcatt tctccatagc 3326581 attgccggtg acgcgacgcc aaagatgacg attccaagtc cgaatatgct gtttttccgc 3326641 ggaaaactgg aaaaggatga atacaaaaac gattatcaac ttttccagca cgatgtatcc 3326701 aaagcatata aaaaagcgat tcaagcgttt tatgacagag gctgccgcta cctccagctt 3326761 gatgatacag cgtgggccgt tttcttatca gaaaaaggct taaaacaaat cgaagcgttc 3326821 ggaacaacgc ctgacgagct tcgccagctg tttgcgaaat ccattaacga cgcgattgca 3326881 gaccgcccgg atgacttgac ggtaaccatg catatttgcc gcggcaactt ccagtccact 3326941 tggacagcgg aaggcggcta tgacgcagca gccgaaacca tttttgacgg cttgaatctt 3327001 gacggacttt tcttagagta tgatgattca cgctcaggcg gatttgagcc gctccgttac 3327061 gtaaaacggt ctgatcttca gcttgttctt ggcttagtga catctaaatt cggtgagctt 3327121 gaaaatccgg atgacgtgaa acgccgtatc gaagaagcgt cccgttatgt aagcttagac 3327181 cagctttgcc tcagccctca atgcggattc gcttcaactg aggaaggcaa caagctgact 3327241 gaagaacagc aatgggcgaa gctccgccat gtggttgaga tcgctaatga tgtttggaaa 3327301 taagcaaaga aaaaaacaca cttgattccc tagcggagca agtgtgtttt ttatgtcatt 3327361 gtgcggtgta gcccccatca aggacgacag cctgcccagt gacgcccttc gccttctcgc 3327421 ttgccaaaaa cacggcataa tccgcaattt ccttgacgga aagcagtcgc ttttgcggca 3327481 caagcggaaa aatgacttgt tcaagtacag agtcgtaagg gacatttcta gttttcgata 3327541 gatcgctaag ctgattgcgt acaagctggg tatcgacata acccggacag agcgcattga 3327601 ctgttatgcc gtggggcgcg ccttccagcg cccctacttt tgtgagtcca atgacgccgt 3327661 gcttggcgct attataagcg gatttccctg caaagcccac taatccatta acagacgcaa 3327721 tattaatgat tctgccaaac tgctgttttt tcatgatcgg aaaaacatgc ttcattgcaa 3327781 taaagggagc cgtcagcatg accttgatca gctgttcaaa ggtgtctgtc ggaaactctt 3327841 caatcggagc gacgtgctga ataccggcat tgttcaccag aatatccaag cggccgtatt 3327901 gtttttggat gacgttcacc gtatcagcaa cttgcgcttc ctttgtcaca tcatacggaa 3327961 tggccgccgc gtcaaagcct tcttctgcaa gcttggaggc tgctttttca catgcttccg 3328021 gacggaggtc tgaaacgatg acgctggcac cttcccgggc gaattctctt gcgatttcga 3328081 atccgattcc gccggcagcc cctgtcacca aagcgacttg ttttctcatg tcaaacacct 3328141 tcccattaag aattgagtac agactggctt acagcgaaat cagcttctgt tttttcataa 3328201 acctcttcaa ttgtgacacc atcctgaagc tccgtcagtg tcatgcggcc gttcacaaaa 3328261 tcaaatacag ccaaatccgt aatcagcctg tgtacgactt tctggcctgt cagcggaagg 3328321 gagcatgttt ttttcacctt tgattcacca tgcttattga cgtgctccat gatgacaacg 3328381 attcgtttcg ccccgttgac gagatccatg gcgccgccca tcccttttac cattttgccc 3328441 gggatcatcc aattggccaa atccccctgc tccgaaacct ccattccgcc gagaatagct 3328501 aaatcgatat gcccgcctct tatcatcgcg aatgactcag cgctgtcaaa ataagaggcg 3328561 cctgtcactt cagtgatcgt ttcctttccc gcattgatca aatccgcgtc ttccgttcct 3328621 tccagaggat aggggccaat tccgagcaag ccgttttccg actgaagcat gacgtgaacg 3328681 ccatcgggta tctcatttgc gacaagcgtc ggcattccaa tcccgagatt cacattcatg 3328741 ccgtccttga tttcttgtac agcccgtttg accattcgtt ttctcgcttc cttcacttgg 3328801 cctcaccctt tcccgatgct tgctgaactg ttcgtttttc aatccgtttt tcttggctcg 3328861 cgccaagcac gacatgctgt acgtaaattc ccggcgtatg gatgtgatct ggatcgagct 3328921 ctcctgcttc cacgatttct tccgcctcgg caatcgtgat cttgcctgcc atggcggcaa 3328981 tgggattgaa atttctcgcc gttttcctaa aaatcaaatt gcccatggtg tccgctttcc 3329041 acgctttgac gatcgccaca tcgccggtaa tgcctcgctc cagcacataa gtccggccgc 3329101 cgaatgtttt atgttctttt ccctcggcta tggaggtgcc gacgcctgtc gccgtataaa 3329161 atcccggtat gcctgcaccg cctgcacgaa ttctctcagc gagcgttcct tggggaacaa 3329221 gctctacctc aagctctccg cttaaaaact gccgctcaaa aattttattt tcaccgacat 3329281 aggaagcgat cattttcttg atttgcttgt tagccagaag caaaccaagc ccccagtcat 3329341 cgactccgca gttattgctg acaacggtta aatcctttac tccctgatct cttatagaca 3329401 aaatgagctg ttcagggatg ccgcacagcc caaaccctcc cgcgatcagc gtatccccat 3329461 catgaatcag tttcgcagct tccttgcttg atgacagcac ttttcccata ttgatgcccc 3329521 tttcgttttc ttctacacta gaccagtcag gctgtaaatc gcgatcacag caaatacggc 3329581 agccgtttta atgagcgtga tcgcaaaaat atcgcgatag gattgccggt gggtcaaacc 3329641 cgtcacggcc agaagcgtga taacggcgcc attatgcggc agtgtatcca tcccgcctga 3329701 tgccattgaa atgacccgat gcatcacctc tggcggaata ttgtaagcct gaatcgcctg 3329761 taagtattgt tctgacatcg cgcttaacgc aatgcccatt cctcccgaag ccgagccggt 3329821 gattcccgcc agcgcagttg tcgtaacggc gccatttaca agcggatcgg taaaagtatg 3329881 tgaaattccg ctgctcagct tatgaaaccc cggcagcgcg gcgataatgc cgccgaaccc 3329941 gtactcagca cccgtattca tagatgccag caaggcgccg ccaattcctt cattcagccc 3330001 ttccttcaat tgggcaaaca cacttctcca atcaaataat atcgttgtga tgatgccaat 3330061 cactaaagca atctccaccg accaaatagc agccgctgaa gaaatatcaa gcctgccgaa 3330121 ctcctttaat cctatggaag aaaaatcaaa tccattcgga taccactttg gcaggtaaat 3330181 ggtgaaatat ttattcactg caccgacgag aataagcggg acaaaggcaa gcgcgtgccg 3330241 aatcgggctt ttgtccggtt cagccgcgga ctcaatcgat tcaggagcag gagcattctg 3330301 cgaatcaaaa ccgccatagc cttcgccaga tgcctgcgct ttcttccgcc ttgattccaa 3330361 atagagcatc ccagctgcca gcacaatcac tgcgcccatc aaacccagcc aaggggcggc 3330421 ataaatgtct gttttgaaaa acgacgtcgg gatgacattt tggatttgcg gcgttcccgg 3330481 aagtgcgtcc atcgtaaacg taaaagctcc taaagcaatc gtacccggga tgaggcgttt 3330541 tggtatgttt gcttcttgga acatgttttt cgcaaaagga tatacagcaa atacgacaac 3330601 aaacaggctg acaccgctgt acgtcaagac agcacccatc agcacaatgg caagtatcgc 3330661 tctttttgcc ccgacaagcc ggacaattgt tttcgcgatt gatgccgcaa gcccggccat 3330721 ttcaacgacc tttccaaaaa tagcaccgag caaaaacact gggaaataca gcttaataaa 3330781 acccgccatc ttctccataa aaattgatga aaaaaaagga agcacatggc ttggatctgt 3330841 cagcagcacc gcgaataacg cgcaaatcgg cgcaaacaat atgacagaaa atccccgata 3330901 cgccgtaaac atcagcaaac ctaacgccaa tagaatgatg atcagttcca cacacacatc 3330961 ccccgtttcc gcgaactaga aagcgtttac aaaaacctgt ccgcatcggc tgtttccgtc 3331021 ccctttccat atgtacgaga agcgtgggcc aactattccg attaaaaaag gaaagctcct 3331081 tttttcggag ctttcctcta ccattcattt cattcctatt aggatatcaa catcaaccgt 3331141 aatatcggct gatttcatct ctttcagcag gctgactcga tctttcggcg ccgaccaggc 3331201 aagcggcgtc atcttgagaa gccagtggat cgcctgctgg tcaagcgttt taacatagcg 3331261 cagcctgaca ggacggctgt gtgctgcatt tgctgtaaaa cgctcaactg ctgccgtatt 3331321 ggaatacgtg cgccttggtg aatcagtata taaaaattgc cttaattcta ttaaatagtc 3331381 gcttcgcggc actactttta tgagcatgcc atcattcttc agcagtctat gaaactctgc 3331441 ataattggac ggcgaaaaaa tagacagaac aacatcaaat tggcgatcat gaaaaggagc 3331501 acgcgccaca tcggcaaccg cccacatcag atctttgaat gccttagaag cttttaagat 3331561 cccgtccttc gaaagatcta tgccggttcc tatcgctgct ttccctgcat aatcaaaccc 3331621 gcaaagcgca ttcaaatgag aaccctcacc gcaaccgctg tccaagatgg tgaatgcctc 3331681 atgaccagat ttgggatgac tgatgagctc tgcaatcgca tcatggagcg ggtcaaaaaa 3331741 accacattct ccaatcagcc tgctcctcgc ttcaaaaagc tcggcaccgt aactggtttt 3331801 gaccggcttc gtcagaaagt tcacgtagcc gtgccgagat agatcaaatg tatgtcctcg 3331861 ttctgtacaa atcaagcttt tccctgatgc cgcatccata gaagaatcgc agagcgggca 3331921 tcgaaacatg ctgaaatcaa ctgttcgctt catgataaaa aacaccccat tcattcattt 3331981 ttagataaat gaaaaaggca tagacaaata aacctaggcc tatctcaaaa attggccagg 3332041 tctggcagtt tgtctacacc tgtcattatc tataacgaat gaattggata atcatgaaaa 3332101 aaactccctt tctgctgtat gggtttcccc gtttccatca tacaacaaat atccaggagc 3332161 tggaacctta tagtgaagaa aaatcagtac tgacatgctg gtatcccgcc aacatcatat 3332221 cagcatagca atccagcatg tttttccttt attttctcat tttagaatat aaattttatt 3332281 attgtgaaaa tagttaaaaa ggttgatttt caaaaagtga aaggataaaa tactgctatc 3332341 atcttagaaa aagacattct tgtatatgat cagtaatatg gtctgattgt ttctacctag 3332401 taaccgtaaa aaactagact acaagaaagt ttgaataaat ttgaacgagt tgaaaaggac 3332461 aagttctttt ctgtttgctc ttatttttca cactttctgc acttccagaa tttgtgaagg 3332521 ataagagctt tttttgtttc cataataacc ctcataggag ttgctatcat gtacttttta 3332581 ctaaaccttg tcggtctcat tgtgattatg gcagttgtat tcctatgttc tccgcagaaa 3332641 aagaaaatca agtggcgccc gatcattacg ttaattgttc tggaattgct gattacttgg 3332701 tttatgctgg gaacaaaagt cggaagctgg gccatcggta aaatcggtga tttcttcact 3332761 tggctgattg cttgcgccag tgacggtatc gcgtttgcct ttccgtcagt gatggcgaat 3332821 gaaacagtag actttttctt tagtgcgctt cttccaatta tctttatcgt cacattcttt 3332881 gatattttaa cgtatttcgg cattttgcct tggctgattg ataaaatcgg atgggtgatt 3332941 tcaaaggctt cccgcttgcc gaaattagaa agctttttct ctattcaaat gatgttcctt 3333001 ggaaataccg aagcacttgc ggtcatccgc cagcagctta cggttttaag caacaaccgc 3333061 ctgctcacat tcggtttaat gagcatgagc agcatcagcg gctccattat cggatcttat 3333121 ctttcaatgg tgcctgcgac atacgtgttt acagccattc ctttgaactg cttaaacgcg 3333181 ctgattatcg caaacctgct gaatcctgtt cacgtgccgg aggatgaaga tatcatctat 3333241 acaccgccta aagaagagaa gaaagacttt ttctctacga tttctaacag tatgcttgtc 3333301 ggcatgaaca tggttatcgt tattttggca atggtgatcg gatatgtcgc attaacgtca 3333361 gcagttaatg gcattcttgg cgttttcgta catggcctga ccatccagac aatttttgct 3333421 tatctgttca gtccgttcgc attcctgctt ggactgccag tgcacgatgc gatgtatgtt 3333481 gctcagctga tgggcatgaa attagcaacg aacgagtttg ttgcgatgct tgacttgaaa 3333541 aacaatctca aatcccttcc gcctcacacc gttgcggtgg cgacgacatt cctgacgtcc 3333601 tttgcaaact tcagtactgt cggcatgatt tacggcacgt acaattcgat ccttgacgga 3333661 gaaaagtcaa cggtcatcgg gagaaacgtg tggaaactgc tcgtcagcgg aattgcggta 3333721 tctttattaa gtgctgcgat tgtcggcctg tttgtgtggt agaaacattg agccatatcc 3333781 cttttcggat atggctcttt tcattattga taaatagagg ctggcacctg cacatcccgg 3333841 attcccgctg cataaggccc caagtcatac tggccgaaga cgatggcgat cccgtttgcc 3333901 gtaaagtaaa acattgtgtc tctgtttagg gttatatcct ctttctttac atcagagaaa 3333961 aacagcacat cgtgtttttt gatatagcta tataggtaat ctctcgtttt gctgactttt 3334021 gttttggtgt tcagaatctg atccagcgtc acccgctttt gtgctttcaa gtcatagttg 3334081 aaggactgga cagacgttag accgtgggcg ccccctgaat agatataatt gagtgtttga 3334141 atgctgagct tgcctgccgc attgtatttg acgctgaagg atgtttgata ttcccgtttt 3334201 aaagccctgc tgttcgcctg cttttttgtt tttcaggtat tcctgatacg attgttcatg 3334261 taggctttca gctcttgatt gattttcttt tcaaacgcgg cattcccgac gtgatgcact 3334321 tgtggatacg ttaactcctt gatctttttg tacgtatggg tgctgacagt cggtgttttc 3334381 gcttgaactg cttttaaaga tggggccgca tatgcaaata cagaaaaaag caagactgca 3334441 atgcccgcgg ctttcagcat gttattccat ttcatacaat ctactccttt gatgtcgttg 3334501 tttatcattc ccttatttaa gcaatacaca cttttataga ctgattaaat cgaaagaagt 3334561 ttctaggtct aacagcatga tttttccaat aaaaaaagag acacaggatg tctctttttt 3334621 tactgtttgc gcccagaaat cgcttcatga agggcttgtg ccaaatctgt atttccgaac 3334681 atctctaata ccgcaatgac agtctggtcc ggaatgtgct ctgcttcgtg ttttggcacg 3334741 accagatcgt ccatggtttt tttcaagctt tcattcagct tttgctgcgg atacgctttg 3334801 gcgtacagct ccatcggatc aagatcatgg ttcacgcacc actgggcaaa caccaaaatc 3334861 atcatatttt catcgcgttc gtaagcttca gtgagctgtt tttcgttcat ttgtcatgct 3334921 ccttatgaaa agtatcttcc ttaaagatac aggagccgat caaattcgtc tatcccaatg 3334981 gcgatgagca gcaaccgcat cgataaatgc cttgctgaaa gcggtgtagt caggttcatc 3335041 tttagccgtt acgatgccta gcccctctgt tgtcccgaca gaggattgaa gaaggtcaat 3335101 tccttcattt gccgcaccga tcgccttgta gtgattgtaa gcttctctga taaacgccat 3335161 cgcttgtttg ttgtctttta actccagtcc tcctgcggca tagacggcat catacagaac 3335221 agaatcaacc gtcaggaacg tgccgctggc ctcaagctgc tgtccgctgc cgcttgtcat 3335281 ataccccaga ttttgactga tgatatccac tgtgattcct tcttgcttta aggcttccag 3335341 tactgtttgc agctcttttt catgaaatcc gtttccggcg agtacagcga cttttcttgt 3335401 tgacgcggtt ttcactgtac gggcttggct taacgcaggc gaagtaagaa tttctttaga 3335461 tgctttacgc ttcgcgggcg ccgccacgcc tactcctttg gcgatttctt ctgctaaatc 3335521 tgcatcgaca ttgctgaaga catcaacgac ctgccgctgt acgtctttgc ttttgacctt 3335581 cccgacctcg aagcagaaag cagaaatgat gtgctgtttc tccacaggag acatgctgtt 3335641 ccagaaaagc ttcgcctgtg agtaataatc gttgaagctg tcgcttcgct ggcggatttt 3335701 tttgccctcg actttttcct gatagtggac gtagccgcct tcttcagctg tcgcaggcga 3335761 cggatcattg ttttgcagtg agtttttatg ataagcgaca ggtcccttat tgatcgtcat 3335821 ccggtgatag ccgtcgtatt ggttgttatg gaatggacag accggccggt taatcggaat 3335881 ctcatggaag ttcgggccgc caagacggat gagctgtgta tccgtataag agaaaagccg 3335941 cccctgcaat agcgggtcat tggtaaaatc gatgcccggc acgacatttc ccgggtggaa 3336001 tgcgacttgt tctgtttccg caaacacatt atcctgattg cggttcagcg tcatttttcc 3336061 aatgatcttc accggcacaa gctcttccgg ccacagctta gttgggtcaa gaatatcaaa 3336121 atcaaacttg aattcatctt cctcatcaat catctgcacg ccgagctcgt attcaacctt 3336181 gccgccgttt tcaattgttt cccacaggtc acggcggtgg aaatctggat ctttcccggc 3336241 aattttttgc gcttcatccc atacgagaga atgcacgccg agcaccggct tccagtgaaa 3336301 tttcacgaaa cgtgcctttc cttgttcatt gacaaaacgg aacgtgtgaa cgccgaagcc 3336361 ttccatcatt ctgtagctgc gcgggatgcc tctgtcagac atcgtccaca tcaccatgtg 3336421 ggcagactca gggttattgg cgacaaaatc ccaaaatgta tcgtgagcag tcgcagcctg 3336481 aggcatttca ttgtgtggct caggcttaaa cgcgtgaacc aaatccggaa atttgattgc 3336541 gtcctgaatg aaaaacaccg gaatgttatt tcccacaagg tcatagtttc cttcttcagt 3336601 ataaaatttt gtcgcaaagc ctctggcatc ccgcaccgtg tctgcggagc ctttagaacc 3336661 cgcaaccgta gaaaaacgga caaataccgg tgtcttcacc gaagggtcct gaagaaattt 3336721 ggcccgtgtg tattccgtca ttggttcgta aacctgaaaa aagccatgca cgccaaatcc 3336781 gcgcgcatgc acaacgcgct ccggaatcct ctcatggtca aagtgcgtca ttttctcccg 3336841 gaaatgaaaa tcctccatca gcgtcgggcc gcgaaccccg gcttttaacg agtgctcatc 3336901 ctctgacact cgcaagcctt ggtttgtcgt cattttcttc ccgctgttat cggtcctgta 3336961 ctgctcaagc tgctcgtcct ttgagtgttc atttacacgt ttgttttggt catcactcat 3337021 gtctgctccc cctttttaaa acgaaacatt ctacagcaca tttacccgtg gcgttcttca 3337081 tataaactgc taatccgctc attaggattt ttggtctaca tataaatatg cggtcataca 3337141 catttgaaat aagccttctt cacagaaaga aaggatggaa gcgcttacca aaaaagctgt 3337201 tgaatagggg aggtcatatc atgcttgcca tactcggttt tgtgatgatg attgtcttta 3337261 tgtaccttat tatgtctaac cggctttccg ctcttattgc tttgattgtc gttcctattg 3337321 tgtttgccct gatcagcgga tttggcaaag atctcggcga gatgatgatt cagggcgtta 3337381 cagacctcgc ccctaccggt atcatgctgt tattcgccat cctgtatttc ggcattatga 3337441 ttgactcagg cctgtttgat cctctcattg ccaaaatctt atcgtttgtc aaaggagatc 3337501 cgttaaaaat cgccgtaggc acagcggttc tgaccatgac catttcgctg gacggagatg 3337561 ggacaacaac ctatatgatt accattgcag cgatgctgcc tctctacaaa cggctcggca 3337621 tgaaccgttt ggtgttagcg ggaatagcga tgcttggttc gggggttatg aatattatcc 3337681 cgtggggcgg gccgactgcg agggttttgg cttccttaaa attggacacg tcagaggtct 3337741 ttacaccgct gattcccgct atgatcgccg gcattctctg ggtgatcgcc gttgcttata 3337801 tcctcggaaa gaaagagcgg aagcggctcg gcgtcatttc gattgatcac gcaccgtctt 3337861 ccgacccgga ggccgcaccg ctcaagcgtc ccgctcttca atggtttaac ctgctgctga 3337921 ctgtcgctct gatggccgca ctgatcacca gcctgctgcc gctccctgtt ctttttatga 3337981 ctgcgttcgc cgttgccttg atggttaact atccaaatgt caaagagcag cagaaacgaa 3338041 tctcggcgca tgcgggtaat gcgttaaacg ttgtctcaat ggtgtttgct gcgggcatat 3338101 tcacaggcat tctctccggc acaaaaatgg tggatgccat ggcgcattct ctcgtttcac 3338161 tcatccctga tgccatgggc ccgcacctgc cgttgatcac tgcgatcgtc agcatgccct 3338221 tcaccttttt catgtcgaat gacgcctttt acttcggtgt ccttcccatc atcgccgaag 3338281 ccgcttccgc ttacggaata gacgccgctg aaatcgggag ggcctccttg ctggggcagc 3338341 ctgtgcatct gctcagcccg cttgtgcctt ccacctatct attggtagga atggcaggcg 3338401 tcagctttgg cgaccatcaa aaattcacta ttaaatgggc cgtgggaaca acgattgtga 3338461 tgaccattgc ggcgcttttg attgggatta tttctttcta aatgtatgag cttgatcgta 3338521 gcattgagtg agtacgtgat ttacagaggg gagaagatca aataggatat tatgagtgaa 3338581 tagaagattc atgccaacaa cttctcatta caatcataag agcctgctat attgcagcag 3338641 gctctttcac atttggcatt atttttttgt atagcgcacc cagtcataat gagcgtatag 3338701 cggatttaca ccattgtagg agccaagcca ttcatcgaca cccgtgccat tccacaagtt 3338761 catcatgatc tttccaggtg ttgtcggaat ttggtttgtt gcagtatgtt ttaattgccc 3338821 gtcgacatac catttaatag agtttggctg ccaatcgaat gcatacgtat gataggcatt 3338881 ggctgcatca aacccgagat caacaatctt ctcatggttt cctgcaccat ttgtataata 3338941 gttaaattga accttcgttg tgtcttttcc taaaaattcg atatcaatct catcccaagg 3339001 agttccatct gttggacctg tgtaagtgaa gaacgatgaa acgatccctg tgtttttagc 3339061 tggtttcatt ctgacttcat aaagtccata gccatatgtt tgaacagaac ggttttcccc 3339121 gcagtcaaac ttgttataag ctgggcttgt tagcgctaaa cgcatttcac ccaatgacgt 3339181 cattgatacg ttattagccc gccacgtgca gttgaacata tttccattcg aataaccatc 3339241 tgctttttgc caaaaaccgg agttatagcc gttaaaaggg tcaaaaaacg atccacctgt 3339301 ttgagctgag gcagtagcag tgactgcaaa caaactcata aacaatccag tgacaagaag 3339361 cagcaacact cgtttcagat aaggcatatt ggcattcccc tttcattgaa agcgttttct 3339421 atgttgatct tacatgattc ttttaaaagg gaacatcggt caaaataatg ataatatcga 3339481 atcttactaa cttgaatcct gtaactatca tcatcttccc tctgaaaaaa ataaaaacct 3339541 aaattaccat cagcacagac agagatgatc cgcactcatt gcaatttagg ttttgcctgc 3339601 tttatcagta acaatcctac cattttcata tgtgaatgta agaaaaagtg aacacaagga 3339661 aacacaaatg tcagcgctct cattatgctt gtttaactac cctttctatg tgaatggtta 3339721 aatacagcag ctcgtcactt gtgagcttgt gctcatactc ccgctcaatg taggtttgga 3339781 ttttcttcgt gcattcatac gcgcgatgat acttttcttt cactgtatcc agcaaaaaat 3339841 cgtcctggct ttccatgtga gtgccgttaa atagacgctg cgcgaaaaac tttaagtggg 3339901 tgacgaaccg ataatagtga agcgattctt cgttgaattc aatcttaaaa tggtatttta 3339961 caatactcaa aatctcttgc atgacttttg taatgttgat aatattgggc atctcttcat 3340021 tcagctcggc atttacaata tgcagagcaa taaagcctgc ttcatcctct ggcagagaca 3340081 caccagtctt gttttttacc ataaccaacg cttctttgcc gatcgcaaat tcgtctttgt 3340141 agagccgttt tgtttcccac agcaaggcgt ttttgatatc aagccctttc tggttgcgct 3340201 ggatggcaaa gttaatatgg tcggtcagcg acacatagat gctgtcgttg agctttttgc 3340261 cgagctgtaa ttttgcgtag ctgataatct cttcggatac ttccatacac tcgatcggta 3340321 tatcatacaa aagggttttg aacttttctg atacatcctt gttatcgagc gtgaacactt 3340381 tctcaatgcg ggcttcatcg acatcatcgc cggacttttt ctgaaacgcg agccccctgc 3340441 ccatgacgac caattctttc ccctgttcat tgaccacgct gatcacatta ttgttgatca 3340501 ccttcgcaat tttcatggca tgtccctcca aatctactaa gaacagacta tatcttgatt 3340561 gtacattctt tttgtactag gtcaatatca tcagggaaag acggaagctg gtcagtacaa 3340621 ttcactccgt acctgctgcc cgggctgttt ttgaagcagc gcctccagat ggcgttcaaa 3340681 tgatgccttg tcagctttct gctttttgac aatgctgttc atgattttaa tgctttcagc 3340741 actgtattgt gtatattgtt ttttcagctg atccagctgc tgtcttgtct tcttcgcgtt 3340801 tttcggtgtg acttggttga tgagtttgat catactgtct gcggtctcaa aaaaaccggc 3340861 tctattttct gtcagctgct gaatttcgat gcggctcata tcttgattac gcgttttttg 3340921 aagcaaggca accgcctcgc tgttttgttt tttgagcgat ttgttctcaa gcttaatcga 3340981 ttcgagattc tccttcgcaa tgtctgcttc ttcttcagtc atgctgattc gcacgaagta 3341041 ttctggattg ccgattccat aatcaaatgc ttcgctcact tgtatcatgg aactgaacac 3341101 aatggccagc tgcctgtcgc ttgcgagggc ttggaaatcc tgctttttct tactgctcat 3341161 cggtttggct gcggtttgtt ttactgtctt ttgatcacag tctgcgaaca tctgagcctc 3341221 accttcactt tcgcatgcgc tcatcacaag aactgtgacc agcaggctta tacacaagcc 3341281 tattcgcctc atgctctgtc tcctctctgc tgaatccctt ctggaaaata ccataaaata 3341341 tagttaaatg gtaccagatg cacctaaccc cagcaataaa tcaaaagtat gatttgaagc 3341401 gaaaaaacat aaatattttg taaaaattga cgtgcattcc attcttttca ggcccatttc 3341461 tcgtacaata gaagtatcgt taccggagag gggctctgat gatgaaacgt tttacgaaac 3341521 aagaaaacag ctgggtgtta tatgactggg caaattcagc ttactcaatt gtcgtgacca 3341581 ccgcggtatt tccgttattt tataaatcag cagctgcgga aagcggtgtc agcgccgctc 3341641 aatcgactgc ctatctgggc tataccattg cgatttcaac gtttattctt gcgatgctcg 3341701 gccctatttt aggcacaatc gccgactatg aagggtgcaa gaaaaagttc ttcggtttct 3341761 ttgtgtcagc cggtgtcgcc agcaccgcga tgctcgcctt tatccctagt gaacattggc 3341821 tgctattgtt gctgttttat acggtatcgg ctatcggttt ttccggcgcc aatgtgtttt 3341881 atgatgcctt tctcgtggac gtcacgcctg agaagcggat gaatctcgtc tcggcacggg 3341941 gttttggctt aggatacatt ggaagcacga ttccatttat catcagtatt gctgtcatcc 3342001 tgctcgcaca agcagagact attccagtgt ctgtatcggc cgcaagccag ctgtccttct 3342061 tcataacggc tgcctggtgg gggctgttca ccatcccaat gattaaacat gtccatcaac 3342121 gctattacat caaaaaagaa cctcatattg tcatcaacag ctttaagcgg ctcggccaaa 3342181 cgatgaaacg gatcaggcaa taccgggcac ttttcctctt cttgctcgct tatttctttt 3342241 atatcgacgg agtcggcacg attattacga tgtcgacatc ctatggatca gatttaggga 3342301 tcggctcctc aagccttctg atcatcctat ttgtcaccca ggtagtcgcc gcgccgtttt 3342361 cgattatata cggaaaactg gcagaacgct tcacggggaa gaccatgctg tacgtcggga 3342421 tcgtcattta tatgatcgtc tgcgtgtatg cctattttat ggagacaacg cttgatttct 3342481 ggatactggc tatgcttgtc gccacctcgc aaggcggtat tcaagcccta agccgttcct 3342541 atttcgccaa gcttgtgcca aagcgccacg ccaatgaatt ctttggcttc tacaacattt 3342601 ttggaaaatt cgcctcaatt atggggccgc tgctcattgc cgttaccgcc cagctgaccg 3342661 gtaaatcctc gactgcggtg ttcagcctga tcattttgtt tgtgattggt attgtgattc 3342721 ttgcctttgt tcccgaggaa accagcacag atgtcagcca gcagcaaaat gacctgcccc 3342781 tttaactggg agcaggtcat tcatcattta ttcgctttat tcaccttcag ctgtttccct 3342841 ttgacggttg tgttcttcat cactttgaga acatgagggc ctttaccatt taaaatctca 3342901 acgtatgagg cgttatccat gatcgtgatg atgccgatgt cgtcagctga cacaccgtca 3342961 attttggcaa tcgttcctac aaaatcaacg gctctgattt tctttttctt tccgccgtta 3343021 aaatacagct tcataatgtc tttattcagc tcttcgcttt tgtccttttt gctttccgga 3343081 cggtcattca gtttagctag aaattctggt ttcttccttg ccacttcctc ttgagaaggt 3343141 gcttctattt tttggatttc aaatccgata tattcttcaa tgtcggctaa aaaccgtttt 3343201 tcgaaggccg tgacaaacga aatggccttt cctttgttcc ctgcgcgtcc cgttcggccc 3343261 gtgcggtgga catagctttc tttttcaagc ggcagatcat agttgatgac aagggagata 3343321 ttttcaatat caatcccgcg cgcggcgaca tccgtcgcca ctaagtaacg gtactcgcca 3343381 cgtttaaatt cattcatgac gtcgaatcgg tcttcctgaa tcattccgcc gtgaatttta 3343441 tcgcatggat atcccaagtc atccaattca tcggtcagct gattgacgtg ctccttcgtt 3343501 cggcagaaaa tgatgcagct gtcgggattc tccgtcatca gcacatcttt cagcaatgaa 3343561 aacttattct cttctcttac ttgaatcacc gcatgttcaa tatttcttgt ggttaggccg 3343621 gccgctttga cctcgatatg ctcggggttt tgcatatatt gacggctcag cttctcgata 3343681 tcctgcggaa gcgtcgctga aaacagcatc gtcgtacgct cagtcggcag atgcttgata 3343741 atcgcctcca cctgctcaat gaagcccata ttcagcatct catccgcttc atcaatgacc 3343801 aaataagaga gacgatccaa cggcagcgtg cctttttcga tatgatccag aacacgtccc 3343861 ggcgtgccga caacaatgtg gcttttttgc ttaagctcag ctttttgttt atcaaaggag 3343921 gattttccaa atacggctgt cgctttgatc cgtttaaatc gtccgatgtt cgtgatatct 3343981 tcctttactt gcaccgcaag ctcacgggtc ggtgttaaaa taagcgcctg cggcttgttt 3344041 tcatcccaat tcgccagctc acagagagga atcccgaacg aagccgtttt cccgcttcct 3344101 gtctgtgatt tgacgacaag atcctttcgt tcaagggcag cggggatcac actctgctgc 3344161 accttggtcg gttctgtata tcccagtcct tccaatgctc gtaaaatgtc atgactgatt 3344221 tgatagtttt taaaatgact catgtataaa ctcctgtctc ttgcagatgt tctcattata 3344281 ctctaattga ccaaggcata tgtgttttgt cgaaaaatga tgtattaaaa gccagcgatt 3344341 ccctggcgtt ttagctcctg aacagccaat cgcgccagtg cgtcggcccc cgcgcgattc 3344401 gggtgcagcg tatctccatc catataaagc ccgagtgttc tttccggacc gatcgatgta 3344461 aagtatgccg agctgaggac atttaagtca atgagatatg ttttttcctc ttcggccaaa 3344521 gctaaaatag aggccctgta ccatctgttt acagacgaat ggatgccttc agaagtaaaa 3344581 tcggttgccc ggccctgagg cgttgatagg atgacgtccg ctcctttcgc ttttacctga 3344641 cgaatcatat cacgcatcac ctctttaaac tccgcttcag attctttatg cttcggattt 3344701 gtgtcattaa tgccaagctg caacataaaa taatctccgg gtttaatata cttcagaatc 3344761 gcctcaagct gtccatcatt tctgaaccct ctcgcgatct gcccgccaga cgccatgttt 3344821 ctcacttgaa aggtgtgttt atcgatatag tgaggcagca tctgccccca gcccgcctgc 3344881 ttgctgctgt tgagcggata ataattgcac accgtcgagt cgccgccgac ataaatggtt 3344941 cgattcgtta ccggctgatc agacaatttc tttattttca aggcgctgag cgtaaaagcg 3345001 gtgcctgcct ttccctctgt caccagcaga ttcagctgcc cgtcggtgac gggaatttgg 3345061 aacgtatcct ccgcgccatc ccctgtcata ttgatgacct gaaacacgcc ctccgctgcc 3345121 acactggccc ttgccgtatt gccaagcgtc accttcacct cataaaggcc attcgggaga 3345181 tcaacattaa acgtgttatt gcttttcgtc ccatacgcta aaaactgaac cgcatcactc 3345241 ttcacaccag ccccggatgc cgccacatcc ctcatattct ccggtgtttg aaaaccgtag 3345301 ccctttgacc ggtcataccg atcagacgcc ctgacaccaa tataaccagg ctccatcgaa 3345361 ccgcttccaa agtcaaactg atacaccttc ggctccgccg ccttcacatt ctcaatcccg 3345421 ccaaaacaca gcatcagcat catcacaaaa accgctgcca tccatttttt catcaagact 3345481 ccccctctat gaaaacgaat acattaatgc atactcggtg attgtttctt tatgatgact 3345541 gaattaagaa aaaaattgcg ttgaggaata aaaatgaggg gagagtctca agaaggggaa 3345601 aatcagtgtg acttcttgtc acacttgatc acatcccaac ctccgcaata gaagcttatt 3345661 tggttttctt cgtcatacac ataataacgg agtctttccc attgatcgtc agtcggtaca 3345721 atctccaatg caaccgaatc gatggattca aggtcatcca gctttgatgc actaatgttt 3345781 tcaaaccgca attgaatgtc acaggtttga gcagatcgtt ttcattcaaa cacaggaata 3345841 tgaatataac gatcatcttc tttcatatag aaagaaaact cgtttaatgt aaatggacct 3345901 gtatcctcat cagaaagatg ctgtttcaat ttctcgtatt gtgtgatatt caaatgaatt 3345961 ccctctattt atatgattca ccgccaatca tataaatgtc cacagcatcg tattcaaacc 3346021 atatgatccg ttcgcctgag tccgttaggc attggagctt cccttctgaa aaatagcttt 3346081 tatccggttg aggatcagtg atcagaaaaa catcatcatt gatggaagct agcagaaaga 3346141 gaaaatctgc aatatcccgg tctgcttcct gtaatatgga ttggaaatgg aattcccttt 3346201 tggccagctt cgtcaccttg taagcatgac cttcaaaata ctcggacagg tcttctataa 3346261 atgaaccagt cgttattacc tgtatcatga ttcgatcgta ggcaagccct gcccaaaaac 3346321 gataaaacga ctctgcatct tcaagttcgc atgccataac ggtttggtca ggcttaagct 3346381 cgatcatgtc caaattgcca atactgctta tagaggttat ttccataaaa tcttcccctt 3346441 atcagttgga tagcgcaacg caaatctctt gtctgacttg ttcatacaag agaatgtgat 3346501 gatacagatc cttatcgttt ttgatcatat ccggaagtat gtcaggatac agctcaaaaa 3346561 agcttttctc caacgaacgc cgctgatgcc ggggtatcct tttattcgcc agcacataat 3346621 ccaaactgcc agcaacaagc ataaaaaact catagatttc cgcttcaaag ccgtacaatt 3346681 catcagggta ctgcttttct tcaagctctc gctgtctttt tctcagtttt tgaagcacgt 3346741 tgatcctctc ccttccgcaa taatctcatt tatttcgaaa cagaataggc ggatcattat 3346801 ctatcgcctc caacagctct tcaccaaaca cagtgattgc acatttccac gggtctccca 3346861 aaagtcccca ggagaagtcc tgatgaaaaa agaaataata gtctccattt ggaaatacgg 3346921 gaacaggcca ttcgccaaat tcatccttag gcattgcctg atgaggacta aaggtatatc 3346981 cgtcatgctg ccaatctagt gcgtacatta catcgttctt tccagtacct aattgaaatg 3347041 cttttaaaat agaagtctct aaatcactta gcactccgct cacatcatta tgaccagctt 3347101 tactgctcat cgcgcttgag atatcaaaca ctcgatatgg atcaggcggg atgatgtgat 3347161 gacatctgct tccgggcttc cattttatga tcttgttcac ttctgaccag atgcggtctt 3347221 gttttgtctg acttaaagcg cgccaattca tcataatctc atccctacac cttattggat 3347281 atcctgctta taaacaccag aagaggccac tgcgtaaaca gcgtaacttg tcagtttcag 3347341 ctgttgaaca tctaggcctt caccgttcga atcacagcat gttatctctt ccatctcttg 3347401 actcacatcg gcagaaatca aataaagaga cgacttaagg tctgcactgt aacaattgaa 3347461 cgtcccaacc aaaaaacctt cttcggatat cgcgagctga tcaaatgctt ctgagtccgg 3347521 ctctttatcc gacagaatcc acacccgtct cacgaccgtt tcatcaaatg cggcaatgac 3347581 tgcatctccg taatacagca tataaatcaa gccgtttttt tctgcaagtc cataacaatc 3347641 atctacagca ggcgcatcca tttcttcaag ctttctatca atgtgtattt ccttctgctg 3347701 accatctaac gtaaaacacc acacactatg gccgttggga ttctcatcat gataaatccc 3347761 ttcatcacat aaaccgaccc aaagctgttg tttctaatcc aaaagacagc aggaaacccc 3347821 tgaaggcaag tgaaaaacac ttttcaccct tccctcttct gaaaaaacct ttaccttcgg 3347881 ctcgtacgat tcgtaataaa cgaagacata gccatctgca cattgttgaa agagcagaat 3347941 atcactgtat gaaatctgct ctttcactct aaaatcccga acatcaccgg aaggatcata 3348001 gattgtaatg gtgataccac ctttcaaccc ttttccaatg tagacacgcc cctgtggatc 3348061 agcatggaaa aaacaatctt gggtgttctc gttgatgatt ttattcaatt ttaatttttt 3348121 cattggttat gctcctaggt tcgaaatgaa atgataagaa taaaccattt attagctatt 3348181 agtaacggac aacctagttt cattaatcgt tttgggataa atctactttc caattcagcc 3348241 ttaaatcatt tagtgtttaa ttggtatgca taaaacgatt gatcatcaaa gcgaactgtt 3348301 tcagcttcta tagcaatcag cattctgttc atgtcaataa gaaagttagc atttgattga 3348361 tactccggaa ttatagaatt tgatagattc ccgattcctt ctggatgata actcatctca 3348421 aatacttgcc aattgtattc ttccggatct attttttcca atctcatgtc gccaacatct 3348481 gcactataat aagcggatgc cacattttga aatgaaattt tatgcgtata ttcaccttca 3348541 tcttcaaaaa ccttaatatc aagtgagagt tcttttttaa acacattaaa atctaaatga 3348601 aggacactgc accccttatc tatataatca acccattcat taatcgtttg atacattgtc 3348661 atcccctgcc tctttttaaa caataacgcc ttgccaccaa gcagaaaaca aattactccg 3348721 tatattgttt gatccaatca tttaaatcat ctgttgaatg caaataagtt tctgatgaat 3348781 ctttcaaatc aatcccactt agaaggatta acatatccca gactctatcg tcttctactt 3348841 cggggtcatc cgcataaaca taagttccag cccaatccga cacttcttct cttgttgttt 3348901 gtccatttaa gacacttttg attttattta tgcattctat tagatttgtc tcgctcaatt 3348961 tgatcaccac gtattcaagt actaaatgat tttttattag tatgcaaagc accgtactga 3349021 tatttagata ttgaagcttt ttccgtaaaa gatatgttcc aaaaggtttc caatctacca 3349081 ataaacaagc tcacatccgt attccgtgtg caatatacat aaaccaaact ggcacttagg 3349141 ctcaaccaaa ataaaactat gattgagaat cccttcatcg aactcaatac actccaataa 3349201 gcagtcaagg tgctcgagac attttccaaa agaacaaact aacgcaccaa tttcgctgct 3349261 gtattgatga aacagcagaa cgtcccggtc atcgtaagca acatatgact gagatatttt 3349321 ccagatcagc tgtttcgctt ccgttttttc gagggcatca acctcacggg tgttggctgg 3349381 tattgaattt gataaaacca gctcaagcaa ttgcctgctt tgcgccagat cagcaaaacg 3349441 ataagtgaag cctctttctg cacaagggac tagtttttct ttgatttcgc tcatcaataa 3349501 acgtctttta ttctcggcga gtttttcgat caatcttttt tgcatgagcc gcattccctc 3349561 cgctgtcaat ttctcaactt cttttaaatt gattcatcat tctcttgttt tcgttgtcgt 3349621 tcatgtttag atttgttcta aaaaagcttg tatcgcttat cgatacaagc tttatcttca 3349681 actgcttaaa actcacccag tgggcttttc acaaaacgct gggaaccttt ttggcaaatc 3349741 ctcttcatcc caatcaattc tatattttta gattcttttg tcatacaaat aagagaggat 3349801 ggtaacatct cttatttaat gttccatcaa taaatgcccc atttttatcc aatgcagaaa 3349861 ttatttataa ttaaggaagt ttagaaggat tttttgtatt ttcaagattt aattttaaag 3349921 cggtcacaaa agactctagc ttttcttcat tacaattaat ttcgaacaag ttggagttcg 3349981 acttactttc tttataatca tcaaatataa ttttaatctt aattctgtaa tttccgtttt 3350041 cttgatcaat actaagaaat aagaatggtt caatagtctc taaactgata ctgtcttgat 3350101 ttccttttat catagtttcg atcccagata tcaacacctt atattcactt tctaataaaa 3350161 cagcagaaaa atcgcgaacg acggctttct tattttccaa caattcaaat acagataaaa 3350221 taaatggatc atcgtccaac tcttgatacc ttctcggtgt taattcaagt tctatacaat 3350281 catcttttat tttggccata tttcctcctc atttaaagtt taagtgaggg tagttgtcat 3350341 ccccccctcg cttaacctta ttaacgcctt ctcttagatt tatttccttt tccgtgtgta 3350401 tggaatacgt gtttagaacc cttagctctt gaacttccat aagctgtgat tactttaccc 3350461 cttttattta aaacaactgt agcttttttt ccaacatatt tcgttgcccc attaggttgt 3350521 tttattactt ttttagggct tcgcacagca ttcagtttgg cccttaaatt gactccacgg 3350581 cctccatttc ttcctataga ttgattaagt ccatgtcttg tatgacctgt gattttaact 3350641 gccttcttcg taaacttata ggcgcgacta gcacccttaa atatcttccc aggaccaaaa 3350701 ttagaagcag ctgcccaagc agcacctttc catcctttac ctgatttata tgccttatat 3350761 ccatcatagg ctgcaaatcc ggcatttacc acaagccata cccaatgccc gtccggatca 3350821 acattcatca ctgggttatt atttccataa gcatacccat tctgatccaa tgaatctccg 3350881 tcgctgcccg ggtctgggtc gagcgatagg aacacgccgt ttcttggctc gtagtagcgg 3350941 gccatgagat agtacaggcc ggtttcttcg tcgtattggt agcctgcgta gcggtagcga 3351001 ttgtctttta cttcgtcgct tgcttcggtt tttgttggat ttccccatgc gtcgtattga 3351061 tacttggcaa cggtttttcc agtgctgtct gagatcgcga tgatgtcgcc gtgagcgttg 3351121 tagtgataga aatatttctt accattttct gtgtaggata acagctggcc gctgtctccg 3351181 tacgtgtatg attttgtgac gttgttgtcc gcgtctgttt catacaagac gttcaagctg 3351241 tctccgtcgt agaagtagtt cgtgactttt ccgttgacgg ttttttggat tctgtttcct 3351301 ttttcgtcat acttatatgt tgcgaatggc ttgtcttcgc cttttttggt aacggcggtc 3351361 aggttatctt ctgcatccca cgtatatgtg aatttgccgt cggatgtgcg gttgccgttt 3351421 ttatcgtaag agatgctttc atcattgact tttgtcagct ggttcatgat gttgaaggaa 3351481 gcgttcaccg ttttgcttga gccgtctttt atagttgtaa cggttttccg gtttccgaat 3351541 ccatcatatg tgtattcaat aacagtaccg tcttcatggg tttctttgac aagctgattc 3351601 agcttcccat actcatattg caccttgccg cttgctgagc tgtttatcgt tgtgcggttg 3351661 ccgttggcat catattcata gctttccgtc agaatgtctc cgccgttttt gtcaccgata 3351721 tgcagcgagc ttacaaggtt tctttcgtca tatgaaaaac ttgttccgcc gccgttgccc 3351781 gtaataaagg tttggacgtt tccattttca tcataatcaa atgaatatga ggatgtactg 3351841 tctttcatct caatcatttg atccagcttg ttatacgtaa attgattcgt tcctttttgg 3351901 tccccatgaa tccacgagaa ggttttcagc ttatcggagt cactaggata tgtccaagtt 3351961 tggctgccgc cgcggtctgt cagttcggtt aaacggtttt tgttgtcaaa tgtccgtttc 3352021 tttgtggtgt tctgctcttt attgacgacc gacgtttcat ttccattttt gtcatacgtg 3352081 aaaatgtact tttctgtacc gttatacgac tttgatttca cccggtctgt tccatcataa 3352141 gaaagagaca cttcgttgcc atttggtgaa atggttttgg tcaggttgct gttggcatca 3352201 tattcgcttg ctaacacatt gccgagaggg tcagttgttt tgacaagctt gcccatgaca 3352261 tcatattcga atttataggt ttgatctgct cctgcccgga tggttttgct tacctcattg 3352321 ccttccttat catagctgtg aaggatagac gtgccgttag agagcgtcat gtttgtcaat 3352381 tggtctgcct gatcatacgt ataggttgtt ttttcacctt ttgcatctgt ttcagacgtt 3352441 ttcttaccag tttcatcgta atcagttgaa gtggcgtaac ctagttcgtc ctcttccttg 3352501 gtcacatagt tgccattact gtcatacgtg cttttagtca gaaggcttcc ttcaatcaaa 3352561 cggatatcat caaaccagac tgtgcctgtc gcactctttt ggaacagaat actgatatcg 3352621 actttattga tcggctttgt tttagggatg acgacagctg ctcggttcca ttcctgtgtt 3352681 ccagaaggga atttcgcatt gtagatgcct gtgctgccgt cagcgtaagt gacattcgcc 3352741 tgcagagaat agtctttttc atctgtaaat ttgacgctgc ttgctttcga cattcctgtc 3352801 agtgtgagat aaaccggttt gtcatttgcg ctttgcccta agacaacggt ttgttttgtt 3352861 actgatccgg cttgggacgc actggtccgg gcagctttta atgatacatc atcattaaag 3352921 ccttcttcag aatcaacgga tgctccgctt acattccagt tttccgttgc tgatgtgaag 3352981 ctgctgtttt gaactgggtt atagcttgat gatacttcgc ctttttccag ctggacttca 3353041 tcaaaccatg cttttccttt gccatcttta tctttatgat cgacttccat atacacaaca 3353101 gctttgcctg cattcgctgg agtcgtaaaa gtgatttgcc gttttgtcca gtcatttttt 3353161 ccggctaatg cactgtattc attgtgaatc cattgaattc gtttttgatc tttgtctcgc 3353221 aaatcaatgt taaaataggc tcttgatttc gcaagatctg ttttgatttt cccgcttaat 3353281 gtataggttg tattcggctc cagctcaact gtttgtgttg ctgacgaata cccatgatct 3353341 gttccggcag acgttgattg gctcaagacc tccaatgcct ttgatccgga aagaactccg 3353401 cttttatcgg cgatgactga aattttgccg ctgtctttag aggcagtcag attccagccg 3353461 gatttttgag cttcaaagct tccatctttc aaaatattag ttgaagctga taaatctttg 3353521 ctcgattgaa tctggtttcc atatttatca taaacagctg ctgacgatga ttttccgctc 3353581 tgatcggttt cggatacagc atccagtccg tcataagcaa tatccgtgac attgccctcg 3353641 gtatccttca tctttgtgac atcgttgttt ttgttgtatt cgtatgtctc agttccatat 3353701 gcatctttaa ccgacgtaac gttgccatct ttgtcatatt gatagctttc cgttgctttt 3353761 ccggtgccga cgtcatttgg atctacatct tctacaacat tgttgccttc atactttgta 3353821 ttcgttgtaa tttttaaccc ttccgcatca tcaatgacct gaatcggatt tcccgcttca 3353881 ttatagccat actgtacttt ccggccattt ggctgtgtca tgagaagcgt ctttttatca 3353941 gcatcatagc tgtagacata tgtttctttt ttagcgttga tcgctttttc gagacggtga 3354001 ccgctatact gatattcggt aaagacaggc tttgcttcgg tactgttagc tgaatattgt 3354061 ttgacaaggc gcccttcact atcgtagtca tagcttgtga cagtcccgtc tgtatctgta 3354121 accttcttca gcaaatcatt ctcatatgag taggtgactt tcttattctt aggtcctgtg 3354181 atggacgtca catggccgtt ttcatcatag gtaaatgtaa gcttgcggcc tgatgcatct 3354241 gtaatggcgg tcagttgatt tttgtcattg taagtataga cagttgcatt gttatggcca 3354301 tccactacct tttggagttt gccgcctttt ttattgaaat aagcgttggt ttgatccttt 3354361 gtttttaata tgaactgatc agctgtttct gttaattcaa gatatacacc ggtcggcggc 3354421 tgatacgtgc catcggcttt tttcgtgaat cgatgtgtcg tagcgtcttc atcgatatac 3354481 attgccccgc catccgttga gatgacagat gtttctgcat cagcatacca gccttgtcca 3354541 aataagtgat cagagctgtc aagactgttg taggttctcg ataagccaag tcccggaccg 3354601 cgtccatcaa ttgacaaatc ttcttcattc acaatgacat tgcctgtcgc accatttaac 3354661 tggccgcttg ggatatcaat gatagaccag tactcttctg tacctaggaa ttctgcgcct 3354721 tcatggaacg ttgggttaaa gggcgccgtt ggaatcgttt caccattcgc atcataggcg 3354781 acaagcgtga aagaataatt cttcttccct ttgtaattcc catttgcatt gttatagaca 3354841 ggtgatggat cgagggctaa ttccccgcct tttccatctg tatgaagctt atagcttccg 3354901 gctttgattt cctcagaagt cggccagatg tttttatttt gggttgtcca atgatcagca 3354961 tcaccaacat caaaggactg atattcttta ccgttgtaaa tgttaacttt atagcccttc 3355021 gcattttgaa ccttttccca tatcaaattc acataacccg tttgactcga ttttgtattt 3355081 gtatacaaat agccagttac attctttggc ctagcgatat caggaagtgc cggggtagca 3355141 gccggggatg caatggcttc gccgtctttg ttgtatgcga taattttaaa cgagtaattt 3355201 cttttggctc catctccccc ggcgttttta taggttggtc cgggattgat cggcagctct 3355261 gctccgcttc cgtcctttag gtgaagagca tattttcccg ccttgatttc tgcacttgtc 3355321 ggccagatct ttttcccttt tgtggtccaa gacgtctgat ttccgagatc aagtgtctca 3355381 aagcctttcc cattgaacac ctgaacctta tagccggttg caccggatac agctttccaa 3355441 gaaaggtcga agtatcctgt ggcattccca ttattgtagc cctttgctga cggtgcttgt 3355501 gcttttccta cattagggat aacgggcttt gccggtgcgg acatcgctcc ttcaccttgg 3355561 tcaaatatcg cactgacgcc aatccaatag tttttgcttg tagcatagct tccgccggaa 3355621 ttcttataga ccggggatgg atctaatgcc aattcagctc catccttgcc gtccagatgc 3355681 agtttatatc tcttggaggc aatttctgcg ctcgtaggcc agattttttt accttttgtg 3355741 ctccacgacg tgacgttgcc tgcagaaatc gcttgatatt ccttaccatt gtaaatccat 3355801 accttatatc cttttgcgcc ttcaaccttt ttccagctga tatcgaaata accagtggaa 3355861 tcgccgttgt gataggcttt gattgtaggt gtgtttccct ttggaatggt atacgtcact 3355921 tcaatatatg gtttattggc ggagttcgct gaagaaatta gttttttcca atattccttg 3355981 ccgtttccgt ttgtatgaag cttaaatcca tagttggccc cgccggagtt ccatgacttt 3356041 acagcagcgg tcacatcata actcgcccac tgtcctttat ggacgtcggc ttttccgata 3356101 tttttagatg ccggtttggt gttccatgtc acttttgcat tatcataatt gctgttgacc 3356161 gtatccagcc aaaggccggt tgcctttgtt ccataatagg aatgggctac gtatgttttt 3356221 aatgtagctt tagtgacagt catattttga attggcttta ggttgttaaa tttcatgaac 3356281 gcatagtttg tgcctgttgt tttgtcataa tagcccgttt tcagtacata ggcctttaaa 3356341 ttagcatccc atttttgtga ggaggccgaa tagttcgtcg tcgggtaggc actcatgaca 3356401 aacgtatccg atgaaacaga taaagaagtt gacgggtcga tagatactgg atatacgcgt 3356461 tctgggtctt tcagccagtt ctcgtctgcc gtaagatgaa gcaaataccc ttcttcattc 3356521 ttttccagct tatagctgac tttgtctgac cgttcaacct cgccggaaag ctcatctagt 3356581 tttgaatccg tcataaaagg cttaggcaca gaaaaaacaa cttttccttt ttcatcagaa 3356641 aaatcaatgg atccatcctc ttgttcttta gcctgcaaat cggtttttaa ctgaaatgta 3356701 aatgtgttgt atccattata ctgatgaagg actaaatctt cttttatgtt ttcattgaat 3356761 gtgaaagtct gaagatcaat attcggaaac acatccggat acacaatctc attactgtca 3356821 gtcttataat ctgctgaggt atctttcgga gtaagtgaag ttttattcgg gcctttcgct 3356881 tctgctagtg aatatgtaac cttatggtca ttatgctcaa aagtcgcata aagcccgttc 3356941 ttcatttgct tttgaaaatc tgaattcaaa atagcgttct ctgtctcgac ttgtttgctt 3357001 gtcgactctt ttaactcagg agaaatgtct tcccagtcgg catccggtgt ttcctttgta 3357061 tgaataggat caaggtatac ttcctgttta tagacaccgt caccttcata atagagtttt 3357121 gtattttctg ttctttcaga ggtgatctca ccctctttgt ttatatcttt tggatcaaaa 3357181 ggtacagctt cctcagtttg ttctttctga agagtttctt ctggatcatc ggcagcaata 3357241 cggtttccat tctcttcttc tgtagatttt gctagtacat cggctggcac taatgaaatc 3357301 attaaagcca acactaaaaa tgctgcaatg aaccttttaa agtttcgcct ctttcttttt 3357361 ttcatttcct ctctcctttt gtaataaaag taatatttac tcaataatct taactagact 3357421 gaaatatcat tacaatattt ttctagaaaa tttatcttat tttaaggatt agcgagagtc 3357481 aattgaccta aaacaaaaaa aggccgcata ggccttttta cattttttat tgtatttgtt 3357541 caatatccgt accctcagct gtcacattcg ccttcccctg cctcctgaca agcgtcaagg 3357601 ccatgcccgc aaagatcatt acgatgccaa gcgtttgata gaggtcaggg cggaagcctg 3357661 tgaagacggt atcgagcacg atcgcgacag cggggtcgag aaatacaatg attgaaataa 3357721 atttcgttga taaaaatcgt aaactgtcaa aaaacagcaa atatacaata cccgtatgga 3357781 tgatgccggt agataccacc ataatccagt ttccctgaga taggtccgca aaagcgccaa 3357841 agtgaataaa cggaatcagg atgataaccc ctaaacctgt ctgcaagaag gtggtcgtgt 3357901 aaggactgag attgtgaatg ccttttccca ataaagtggt gaacgcataa aacagtgcgg 3357961 cgagaactgc ccatatgatc cctgatccca tcagctgtgt caatgatgtg ctgccgttaa 3358021 tcccggaaat cagcgcagtc ccaagaaagc agatgataat ggagctgacg gagatcacat 3358081 ttaatttctc tctgtagaag aagctcccca gaagaagaac aagcaccggc gctagatgat 3358141 aaacagagat ggcaattgta acggacgttt cttcaaaaga cttaaataag aacacccagt 3358201 tgaatacaag aaagaaaccg cacgccaatg tttgcagcac gtctctcttg ctccattttt 3358261 cagttttata ctggccggac gccagccagc aaaagcctaa aaacagcgtc gcgcaaaggc 3358321 agcggacaaa gaccaattca aatgacggca gattggtatg ctctgagaaa aagccgatgg 3358381 agccgaaaat caccatagag atgaccattt tgattacggc tgttgatttt tgttttgacg 3358441 atatggaagg atcctgttgc atcaaacgta ttctacctcc aatactgcat agcataaact 3358501 gttttttgtg aattcagaaa tctacacata gaattcctct tttttacatg tagatattat 3358561 aacacttcta ttctaaataa aaaaaagcgc ccaagggcgc tttttttaca aatctatcga 3358621 acaatcaaaa ccgggcatgt tgataattga gacactttat ggctgacgct tccaagcatc 3358681 atttctttca ggccgctgat cccccggctg ccaactacaa tcaggctgac gcctttctct 3358741 tttgcgtgat ttagtatctc atgcgccggc tcgccattcg cgtaaatggt ttcagcttga 3358801 acgccttttt cggctgcttt ttcttttgca ttctcaagga ttttcaggcc ctctttttta 3358861 acctcgttcc tgatttcatc aataaagtgt tcaggcacat agacaattcc cgtcagagaa 3358921 gaagtcgtga cgacggcttc tctccccaca tgaagaatgc ttagttccgc ttgttgctct 3358981 tttgccaaat gcactgcggc atcaagcgct tttgcactca tgtctgatcc gtcaatcgct 3359041 actaacattt tgttaaacat gctcttcccg cctttcggac tgtgggtggt tcatctttct 3359101 cttttattgt ccgcctgcat ttcgttattg tcaattgaag cgcatgagtt ttcaaaaaat 3359161 tgtcagagac tctctccgtt tgtggcgata acctgctgat accagttgaa gctttttttc 3359221 ttgatgcggt taaatgttcc atttccttca ttgtcccggt ctacataaat gaagccgtag 3359281 cgctttttca tttccgcagt agatgcgctg acaaggtcaa ttggccccca tgatgtgtat 3359341 ccgattaatt caacgccgtc cgcaatggct tcgcgcgctt caattaaatg atcacgcaga 3359401 tagttgattc tgtaatcgtc ctgaatcgtg ccgtcctctt caaccttgtc tacagcgcca 3359461 aggccgtttt caacgatgaa cagcggcttc tggtaacggt cgtataaggt gttgagcgtg 3359521 atgcgcaagc ctttcggatc aatctgccag ccccattctg atgatttgag gtaagggttt 3359581 ttgactccgc ccagcaggtt gccccctgat tttgcaagct cttccggatc tgtgctcgcc 3359641 gccatcgaca tgtagtagct aaatccaata taatccaccg tatgttcttt caagagctct 3359701 tcatcgcctt cagccatttc aatttcaata ttgttttctg ccagatagcg tttcatatat 3359761 cccgggtatg cgcctcttgc ctgaacatct gagaagaaaa gtgttttgcg ctcattctcc 3359821 attgccgcga agacatcctc cggcttagaa gtcatcggat aggttgtcgt tgccgctatc 3359881 atacagccga ttttcgaatc aggaatgatg tcgtgacccg ctttgacagc aagagcactg 3359941 gccacaaatt ggtggtgtgc cgcctggtac atcgcgttta atttgttttc tccttcttca 3360001 aaaacaagac cgcctccggt aaatggcgca tggagcacta cgttaatttc attaaacgtc 3360061 atccaatact tcactttgtg ttgatagcgt ttgaaaaccg ttttggcata gcgttcataa 3360121 aactctatga ctttgcgatt cttccagccg ccataatttt tcactaaacc gagcggcatc 3360181 tcataatgag agatggttac gacaggctca atatgatgct ttaacagctc atcaaacaga 3360241 tcatcataaa atctgaggcc ttcttcattg ggctcctctt catcgccatt cggaaaaatt 3360301 ctcgtccacg caatcgatgt gcggaacgcc ttaaatccca tttctgcaaa taaggcgata 3360361 tcctctttat aacgatgata aaagtcaatc ccgttgtgat acagattcaa ggaagtcatt 3360421 gattcatcaa atggagacat gatcccgttc ggcgatacgt cagctgtcga aagcccctta 3360481 ccaccctcgt tataagcacc ctccacttgg ttggcagcaa ctgcgccgcc ccataaaaat 3360541 ccttctggaa atcgtttttc atttgaactc atattgatca ccccattagt tttttcaaga 3360601 taaagcaagc agcgcttctt ttggctgcac tttaccgatc tctttcaccg gcgaaaacga 3360661 atattggtct gtgttggtca caatcaccgg ggtaatgacg tcatatcccg cggctttgat 3360721 ttgctccaga tcaaaggaca cgagcggatc tcccggtgcg accttgtcgc cttctttgat 3360781 gtgagccgtg aaccattgtc cctccagctt taccgtgtcc aatccaatgt gtatgagtat 3360841 ttcagctccc tgatcactcg taatgccaat tgcgtgtttt gttttaaaaa tggtggtaac 3360901 gcttccacga acaggcgaaa caacttctcc ttcttcaggc tcaatggcaa atccttttcc 3360961 catgacccca gcagaaaaca ctccgtcttt gacttcactt aaggctttca cttctccctt 3361021 aatcgggctg tgaatgatct ctctgctgcc ttcatgcact gccggctgct ggctgccgtc 3361081 agaaggcaca tcctcgaatc caagcaaata cgcagctgct gttcccgccg caaacgcaat 3361141 cacaaggccg atcatcgcgt aaataaacgt tgggccgata aagacaggga tgctcggcag 3361201 acctgcattc cccccgacga tataggaagc aacacccgtc atgccgtaaa acgcgccacc 3361261 ggctgcaccg ccaatcaaag cggccgcaaa cggctttttc aatcgcatat tcacgccgta 3361321 catcgcaggt tctgtgatcc ccatcagcgc cgtgatgctt gtggtaagcg cgagtgattt 3361381 aaattttttg tttctagagc gaaggaagac ggcaaatgat gctcccgcct gccccatatt 3361441 cgccaaaaac atagccggca gtaaataatc gtggccgttt tgagcgatgt tgttgatcat 3361501 gatcggcaca aaggcatagt gcatgcccgt cataatgatt aaagagaatg tacccgccag 3361561 caaaatcatt gccacaagcc ctgcatgatc aaacaaataa ttgaccccag aagacaagta 3361621 ttctcctaaa atagcgccaa gcggaccgac tgtaatcaat gtcagcggca cgacaatcaa 3361681 tagcgtgaat gtcggaacca caatcaattt gagagatgcg tgtgtaaaac ggtcaatcca 3361741 tttttccacg tatgaagcaa tccaaatcga cagcaaaatc gggatgaccg ttgacgaata 3361801 agtggcagcg gttacaggaa gcccgataaa ggaaatcggt ttccccgcac cgagcagggc 3361861 tgtcaaatcc ggatgcagga tcgccgccgc aatggcagcc gctacgtacg gattgcttcc 3361921 gaattttctc gccgcactca tcgctagcag gagcggcagg aagtagaacg caccgtcacc 3361981 gacagccgtc aaaatgacat gaacctggct cttctccgcc atccagccaa acgtgactgc 3362041 cagcgccaca agtcctttga tcatccccgc tcccgcaatc gcaggcagaa taggggtaaa 3362101 caccccagaa atcacatcaa agaccgcact cagcacattc tttttctgag aggatgaacc 3362161 agcgctcttt tcatcactga gattgctgtg ccgcacaatc gcctgataca ccttcggcac 3362221 atcgtttccg ataatgattt gaaactgctc gccgctgata ttggtgccca tcactccagg 3362281 cagctgctcc agctgactgc gatccgcctt cgcgttgtca tgaagattaa aacgcagcct 3362341 cgtcatgcag tggatcacgc gctgaacgtt ttcttcaccg cctacgagtt gtaatatgtc 3362401 cttcgataat ttatcataat ccatgtgtat acctcctttt tatgggggga ctgctggatg 3362461 aaaggtggcc gcctttcacc agcttttttt gtatcaaatg ctgcatcacc tcctaaaaga 3362521 gaataaaaaa acctaaatga cacagattgc gagagtctcc tcctgcacct gcaccattta 3362581 ggttttgcct gctttcgcag taacaatcct gacgggtcgt tttatttgtt tgtaggtata 3362641 ctttagcact agattcgtga gatgtcaacg ctttcatttt tggtgttgac tatcgtttct 3362701 agaacaaaag taatcataaa gatttgaact tagtattaac ttcaataaaa aattattgta 3362761 attaaaaacc ttgaaaggca ttttttccaa tcaaggttat gaatcgttac cgtttaaatt 3362821 tttttaaaga cttctttatc tgtactatta cattctttag ccaatctatt ggttctaaat 3362881 taaacgcagg aagatacacg ccatctgcgc aagattgaat gtaatcgttt ttcttattgt 3362941 ctgaatgctc actttcaata aaatccgtta aaaagacaat agcatcctcc aaatattcct 3363001 tactttcctc tattaataac tcttgtatag cgtcatcagg agtttcaata tcttgatgga 3363061 atgttccagc taaaaactga aaaacagggt ccttctgttt attgatcaat aacatgtcat 3363121 cttgctcctt taagggagag gtaacgggat aatgttaaaa tcattcatca tctaataaat 3363181 caagataata ctgatcattc tcttctattt ttcttaagaa ctcggtaaga gaagttgcaa 3363241 tttgaatatc ataatagtaa atcggatttt tattattatc atttaattca attgacatta 3363301 atgccgattc actaccttca aaaaatatta atttatcatt ctcaaactca tcatatattt 3363361 ctatgtcagg ataaaattca aagtcattta tcctcaatcg aaagtctctt acagaatatg 3363421 gatccaaaat gcgattagta ttaaactctg atcctttaat aaacccatag ccaacttcta 3363481 aataaaaatt cactaattca ctaggtaatt ttaagtttaa atttttttca acctcttcaa 3363541 tctcactttg attcactgga taaaaatcat tttctttgtt tgattttata aaattataac 3363601 tcattttttt ttgcctcctt taaataattc atttgctggt gagcctgtac catgaatccc 3363661 agcttgatgc tcgttaggaa attttgctgg atgcatattc caccattcat gttctccgcc 3363721 aaaagtattt tcaattatat ggtgagcatc atacttatcc cctttttttc taataatttt 3363781 acctgttttt tcagatacaa cattttcctt ataaacaggc catttttgtc cagtgttttc 3363841 ttcccattct tttataactt tattttttac tttatcaaat ttagtcctgt gttttgcagt 3363901 ctctattggt gacatttttt tatattcttt atttcttaat gcttccttta atttatctat 3363961 ttgattttta ggtaattctc tacctgtgcg ttgttctata tctctagcat acttttttat 3364021 taaatcagaa ttaattttat tagcagatcc acttacatca ttcgcaattt tccctttatc 3364081 cttagcaacg tttttaactt ccgaagcctt cttagccttt ttcccattat taataagttt 3364141 attaatatct attaactttt ctaacttagc tattttggca aatggtactg agtttatgga 3364201 ggcaacaaca cggtctttcc ctgtgacttt ttcgcctgat accggatctc tgcccgtggc 3364261 tgctttaaat agatcataca cgccggtaag ttctacagcc gtctctaaaa ttttcacata 3364321 tccattctca tccactttaa tgtccgaaag cgagacgaca ggttcaagct tcatgtcatt 3364381 accagatatg tatacattgt aaagtgtatc attataaacg acttgcttaa cctctgcatt 3364441 tgagaaatca gtttttatat gttctctatg ttcactcgta ttatacactt taccattgat 3364501 aacgatgata tttttactta cctttttaga atcacccgtt ttgacaactg aatccacttt 3364561 agacttttca ttctcggcta atttcttcag catcatctcc atcggtgaat catccgcctg 3364621 cttcatttgc gggttaatcg cgccgaagat ttggttgatg ttttcttctt cctgtgattt 3364681 caggatggag ccgcttttgt agcctgtgat ttcaattttc gggccggtgt acatggtttc 3364741 gagctgatca atgtattttt tcatcgtttg aaaatctgat tttgcggctt ctagtgcttg 3364801 ggtttgctgg ccgtcaaatt gaaagagctt attcagggtg tctgaaatca gccgctcagc 3364861 ctgttctgtt tccatccgaa aaaaggaatc attgactgtc ggcaggctga cgatgtgatc 3364921 tatggctgat gtctggcgat tgactgcgtc agtgagctgc tctgtcactt ctcgtgcatg 3364981 cttgacccca tgtctcgcat cgtgtgagag aaaagcctct gcgatcatgc cgtgggagtt 3365041 agattctaca gaggaaatcg catgctgtgt ttgtttcagc acttttttgt attcgtcgat 3365101 aaatatgcca aagaaaagga gaaaaggctt gtggcactcc tcgtaaaagg tccggatggc 3365161 atctccgcct tttcctttca gcgcatcctt catgcctgcc agatgctcaa cgcttttttc 3365221 cagcttctcc agctgttgtt tttgcttgtc cagtttctca atcgtatgct gaatgccctc 3365281 gtgaagagcg tggacatcta atgttttcaa tcccttgtcc tcccgcgctt tatttcatgg 3365341 aagatgatat gttttcgtcc gtttccttca tggcgtttac cgcgctttcc gtttgtgcga 3365401 tatgcttggc cagaacagac gcatatgctt cagtgagctc tttgatgtcc ttatttaatt 3365461 gctcgatgga cttcacaaca ttcaaatggt ttctgcctga gagatgaccg ggcaatgagg 3365521 acttgagttc agctgaattc ttgagctgag aaagcccttg cttcactgtg tcatacacca 3365581 ttttaatttc ctgtgccatt tgtgctcacc tcacttttta tgtttttcct tctctatttc 3365641 atgctctatc ctcgtgattt ggcgtcttat agaatacaca tcgccctcta atgagtggat 3365701 ttttccttct atgctttcga tgattccgct gacttgatcg cttttgattt gctgatatgc 3365761 tttgttcatt ccttcacgaa tatcttcaaa ccgctcagca tgtgttcctc tccatgcctc 3365821 ccggttaaga tgaggccggt gaatgagatg ctgggcctca gagaaatcgt gtttgatttg 3365881 cctaatttcg tgcagcactc gttttaattg atggatctgt tcctgctttt catgtaagtc 3365941 ggcttttacc gaatgtaaca acatttcact atgcatgccg caacacctcg tgtttctatc 3366001 aaactgtgta aattctttac aatacagact attttcatat tacatgatgg gtcatattgg 3366061 ataaataggt aaaaaggatt gtcttgagag gtatagaact ggttctaaat tgctaaaaat 3366121 acgatctcat caccctatga aaggagaaaa caatcatagt agggactttt tatttaagcc 3366181 tttaatctct cctccagttc taatttttcc tcccacttaa ctgtttctta tagtcaataa 3366241 agctcataaa aaaacacctt ccctcgaagg cgcttctcca tcttatttag atccccatac 3366301 agcctcaccg ctggtattca gcacactaaa cgtcatgacg ttcttctctc tcaccgaatc 3366361 ccactggcgt aaaaataccc cgttatactt cttgcctgct aacgtgatgt cggcggtgtt 3366421 ttttccggtt ttcctccatg ttccggtcat ttccccggaa atggtgtggt ttttgttgag 3366481 ctggatgttg atggtttgtt tgatgtcggc tgagatgtct tttccgtgct ggataagttt 3366541 gtatgttcct gtgatgtctt tttgttttac ttctttcaat gtttcgcccg cataacgata 3366601 tggtgctgct accggccagc cgtctttgtt catgaacaat tggtggactc tgacttcgtg 3366661 ttcttcaccc ctgcccggga agcgggtgtg gaagattaaa taggaacgcc cggttttttc 3366721 atcatagtat gcggagttgt ggcctggtga gacgtacccg gtgccttttt cattttctgt 3366781 ttcaaaagtg tagctgccca tgagtttgac gccgtatggt tcgatggaac ggtcgtcgaa 3366841 gaatgtgcct cccttgccgc ggacgtcgag cattggattg ccttctgcat catagtaagg 3366901 gccgtccggt ttcttggagc gggccacacg gatgttgtag ccgcctgttg catcgagacc 3366961 gccatatgat aggtataagt agtagtattg ggtgtctgga ttgtagagaa catacgggcc 3367021 ttcgattctg ctgtggttgc cgccgagcag ttttttccca tatccctgtc caggaagcgg 3367081 gaagcccgtt ttcggattca tttcaagtat gaaaatgccg cctgagtatg atccgtacac 3367141 catccacagc ttgccgtctt tatcaaagaa ggtatgcggg tcgacgacat tcggatgttt 3367201 ggttgcatca tacggtgttc catcgctgct tgtgccttcc attcctgatt tcaaaaagat 3367261 gcctttgttt ttgtatgggc cttcgatgtt gtcagcaacg gcaacaccca tggcggatct 3367321 tggcgaatcg ccgcggcagg cgttgtagta catgtagtat ttgccgtccg ccagctgcgt 3367381 gacgtcagcc gcccaaagag tatcggattg cgcccattcg aaggtttctt ttaattcttc 3367441 atagacattc gggataagtg ggttgtcatt gcttacgctg gtggtcagct gctgccattg 3367501 catgaggtca ttcgatttag ctgaagcgag atgagatcca aaaacataaa aagtgccgtt 3367561 tgtttcaatg atggaagggt catggacgct gacttcttta aatataggtt tttgtgcata 3367621 gacggagttt gggagggtga aggccatgat aagagctgca agaaaacata cacggaacaa 3367681 tcggttgaac atctaaacaa ttcgcctctc ttttttatta aattttaaac gcttacattt 3367741 ctctatgaag ataccccggc ctattaaaac agccgaatgt tttcatattc atccagatag 3367801 gtgatttctc acttcactta catagtcaga ctgatgtctg tctgttttgc gcagaacttg 3367861 ttgcttgcat atcctctcct tcatagttca actcttttgc tgtttctcct tcttgcatca 3367921 cgtctgtttt tctttcgcgt acatgtaata actgctttgt caggttttgc atcaactgtg 3367981 atacagccat ttcgttgtcg gcgtttttta agatgatgcc tgattgcccg tcaacaccag 3368041 agtcattcgg ctggctcttt ataaaacgcc ttgcgaaaaa tacgacttag taaacgcata 3368101 ttgagagtta gacagcggcg cttgcctcct tgtctggata tcgtgtgcaa tcgctgaaaa 3368161 aacctgttct gctttctgcg tcacgctatt acaatagcaa tctaacttgt taaagactat 3368221 aaaaaaacct tttgacttct gctgctgaac caattaatat aatactcagt taatagttat 3368281 cagaattttt aggaattgag tgattcatat gacactgcat aaagagcgtc ggatcggccg 3368341 gctgtctgtt ctcctgctgc tgaatgaggc ggaagaaagt acgcaggttg aggagctgga 3368401 gcgagacgga tggaaggtct gtcttggcaa ggtaggatca atggacgcac ataaagtagt 3368461 agccgcaatt gaaaccgctt ccaaaaagag cggtgtcatt caatctgagg gttatcggga 3368521 gtcacatgcg ctttatcatg cgacgatgga ggctttgcat ggcgtgacca gaggtgaaat 3368581 gctgctggga tcgctgcttc ggacggtggg attgaggttt gccgttttga ggggaaatcc 3368641 ttatgaaagt gaagcggaag gcgattggat cgctgtctcg ctttacggaa caatcggggc 3368701 gccgattaaa ggtcttgagc atgaaacatt cggcgttgga attaatcaca tatgaaacag 3368761 cccatagatc ttagacgata gggggctatg cgtgaaaaca gaagttcaca gcatagctcc 3368821 tttttgtatg ggcgctttac caaagtaaag aaaaaggagt tgggcttatg gtgactttag 3368881 acggttcttc attgacaaca gccgacgtcg ctcgtgtgct gtttgatttt gaggaggcag 3368941 cggcttctga ggaaagtatg gagcgcgtga aaaaaagcag agcagcagtg gaacggattg 3369001 tacgcgacga aaagacaatc tacggcatca acaccggatt tggcaaattc agcgatgtcc 3369061 tgattcagaa agaagactcg gcggcgctgc agctgaattt aatcctttct catgcctgcg 3369121 gagtcggcga cccttttcct gagtgtgttt ccagggcaat gctgcttttg cgcgccaatg 3369181 cgctgttaaa aggcttttcc ggtgtacgcg ctgagctgat cgagcagttg cttgcttttt 3369241 taaataaacg cgtccatcct gtcatccctc agcaaggatc acttggcgca agcggagatc 3369301 tggcgccgct ttcccacttg gcgcttgcgc tgatcggaca aggagaagtc ttttttgagg 3369361 gggaaagaat gccggcaatg acaggcttga aaaaagcagg tattcaaccg gtaacgctga 3369421 catccaagga agggcttgcc ttgattaacg ggactcaggc catgactgca atgggggtgg 3369481 tcgcctacat cgaagctgag aaactagcct atcaaacaga acgaattgcc agcttaacga 3369541 ttgaggggtt gcagggaatt atcgatgcat ttgacgagga tattcactta gcccgcggct 3369601 atcaggagca gatcgatgtc gcagaacgaa ttcgctttta tctatctgac agcggcctga 3369661 caacctccca gggagaactg cgggtacagg atgcctattc attgcgctgt attccgcaag 3369721 tacacggtgc gacttggcag acactaggat atgtcaaaga aaaattagag attgaaatga 3369781 acgcagctac agacaatcca ctcattttca atgacggtga caaagtgatt tccggcggaa 3369841 actttcacgg acagccaatc gcctttgcca tggattttct gaaaatcgca atatcagagc 3369901 ttgcgaatat cgcagagcgt aggatcgaac gacttgtgaa tccgcagctg aatgacctgc 3369961 cgccgttcct gagccctcat cccggtctgc aatccggtgc aatgatcatg cagtacgccg 3370021 cggcctcact cgtttctgaa aataaaacac tggcccatcc tgcaagtgtg gattccattc 3370081 cgtcatccgc caaccaagag gaccatgtca gcatgggaac catcgccgct cggcatgctt 3370141 atcaggtgat cgcaaataca aggagagtca ttgcgatcga agccatttgc gcattgcagg 3370201 ctgttgaata cagaggcata gaacatgcag cgtcctatac gaaacagctt tttcaagaaa 3370261 tgagaaaagt cgtgccgtcc attcagcagg accgtgtttt ttcctatgac attgaacgct 3370321 tgactgactg gctgaagaaa gaatctttaa tacctgatca tcagaataaa gaactaaggg 3370381 ggatgaacat atgactgatg taaaaaaatc aatccgtgcc aacagaggaa cagagcttga 3370441 atgcttagga tgggagcaag aggcagtgct tcggatgctt cgaaacaacc ttgatccaga 3370501 agtcgccgag aagccggagg acctcatcgt atatggcggg attggcaaag ccgcacggga 3370561 ttgggacgct tttcacgcca ttgagcattc cttgaaaaca ttaaaaaatg atgaaacatt 3370621 gctcgtgcaa tccggaaagc ccgttggcat gttccgtaca cacccgcagg cccctcgcgt 3370681 gctcctagca aattctgttc ttgttccgaa gtgggcagac tgggagcatt tccacgaact 3370741 tgagaaaaaa gggttaatga tgtacggaca gatgacggct ggcagctgga tttacattgg 3370801 ctcacaaggc atattgcaag gaacctatga aaccttcgct gagctggcgc gacagcactt 3370861 cgggggcagc ttaaaaggaa cgttgacgct gacagcgggt ctcggcggaa tgggaggcgc 3370921 ccagccgctg tcagtcacga tgaatgaagg cgtcgtgatt gccgtcgagg ttgacgagaa 3370981 acgcatcgac aagcggatcg aaacaaaata ctgcgatcga aaaacagcat cgattgagga 3371041 agccttagct tgggctgaag aggcaaagct ggcaggaaaa cctttgtcca ttgcacttct 3371101 cggaaacgca gctgaggtgc atcacacact tttgaaccga ggcgtcaaaa ttgatattgt 3371161 gacagatcag acatctgccc atgacccttt aatcggttat gttcccgagg gctattccct 3371221 tgatgaagct gaccgtttgc gtcaagacac tccagagctt tacgtgcgcc ttgcgaagca 3371281 aagcatgaaa aaacatgtcg aagccatgct ggcctttcag caaaagggct ctattgtatt 3371341 tgactacggc aacaatatcc ggcaagtcgc aaaggatgaa gggctggaga atgccttcga 3371401 ttttccgggg tttgtccctg cctacatccg ccccttattc tgtgaaggaa aagggccgtt 3371461 ccgctgggcg gcgctttccg gagatccggc agatatttac cgtacggatg cgttattaaa 3371521 agagctgttc ccgacaaata aagcccttca ccgctggatt gatatggcac aggaaaaagt 3371581 caccttccaa ggcttgccgt cccgtatctg ctggcttgga tatggagaac gaaaaaagat 3371641 gggcctcgcc attaacgagc tggttagaac cggggagcta aaagcgcctg tcgttattgg 3371701 gagagatcat ttggactgcg ggtctgtcgc ctctccaaac cgggaaacag aagcgatgaa 3371761 ggatggaagt gacgctgtcg gtgattgggc tgtgctaaat gcgcttgtca acacggcggc 3371821 gggtgcaagc tgggtttcct tccaccatgg cggcggcgtc ggaatgggct attcccttca 3371881 tgccggcatg gttgcagtgg ccgatggaag tgagctggct gacgagcggc tcgcgcgggt 3371941 cttaacgagc gacccaggaa tgggcattat ccgtcatgcg gatgcgggtt atgaacgtgc 3372001 cgttgaagta gcgaaggaac aggacattat cgtgccgatg caaaaataaa ggagtgatga 3372061 catgccaaag caaattgata cgattctcat caacatcggt cagcttttga cgatggaaag 3372121 cagcggtccg cgggcaggca aaagcatgca ggatcttcat gtgatcgaag acgctgttgt 3372181 cggcatccat gaacagaaaa ttgtgttcgc cggacaaaaa ggggctgaag ccggttacga 3372241 ggcagacgaa atcattgact gttcgggacg ccttgtaacg cctggcctcg ttgatccgca 3372301 cacccatctt gtatttggcg gatctcgtga aaaggagatg aaccttaagc ttcagggcat 3372361 ttcatatttg gatattctgg cgcagggcgg cgggattctg tctacagtca aggataccag 3372421 ggcggcttca gaagaagagc tgctgcaaaa agcccatttt catctgcaaa gaatgctgtc 3372481 ctacggcaca accacagcag aagtgaaaag cggctacggc ttggaaaaag agacagagct 3372541 caaacagttg cgtgtcgcaa agaaactgca tgaaagccag cctgttgacc ttgtttccac 3372601 atttatggga gcccatgcga ttcctcccga atatcaaaac gatccagatg attttctgga 3372661 tcaaatgctt tcccttttgc cggaaatcaa agagcaggag ctcgccagct ttgctgatat 3372721 ttttacagaa acaggcgttt ttacagtcag ccaatcccgc cgttatttac aaaaagcagc 3372781 tgaggcaggc ttcggattaa aaatacacgc agatgaaatc gatccgcttg gaggtgctga 3372841 attagcaggt aagctaaagg ccgtctcagc cgaccatttg gtaggtacat cggacgaagg 3372901 cataaagaaa ttggctgagg caggaacgat cgccgtcctc ttgccgggca cgacatttta 3372961 tcttggcaaa agcacatacg ccagggcaag agctatgatt gatgaaggtg tatgtgtcag 3373021 cttggcaacg gattttaatc ctggcagctc gccgactgaa aatatccagc tgattatgtc 3373081 cattgccgcg cttcatctga aaatgactgc agaagaaata tggcacgcgg tcacagtcaa 3373141 tgccgcatat gccataggaa aaggagaaga agccggtcag ctcaaagctg gccgctcagc 3373201 tgatcttgtc atttggcaag ccccgaacta tatgtatatt ccgtatcact acggggtcaa 3373261 tcatgtacat caagtcatga aaaatggaac aattgttgtc aacagggagg gagccattct 3373321 tggataagta cccttttctc agagaggccg gatcttcgtt taaagaccgg gatgtcacaa 3373381 aaatgagcga cctgatcgca acatgggacg gccaggacat taagggaccg gcgttgatag 3373441 gtgtccccct atcaaaatcc tccatcagtc attcaggcgc ttcctttgca cccggaacaa 3373501 tacgccaggc tctgaaacat tcatcagcct attctgctga gcttggagag cacgtcgtat 3373561 cagagcttct atatgacctg ggggatatcg atattcatgt cactgatatc gtaaagtcac 3373621 atcatcacat tttccaaacc atgcacgctc tgctttcgga tcatccggat tgggtgccgc 3373681 tcatacttgg gggagataac tctatcagct actccacaat aaaagcgata gcacaaacaa 3373741 aaggaacgac agcggtgatt caatttgatg cccatcacga tgttcgcaat acggaggacg 3373801 gggggccgac aaacggcacc cccttccgcc gccttttgga tgaagagatc attgaaggtc 3373861 aacatttgat ccagctgggt atcagagaat tcagcaacag ccaggcctat gaagcatatg 3373921 caaaaaaaca taacgtgaac attcacacga tggacatgat ccgggaaaaa ggactaatcc 3373981 caacgataaa agagattttg cctgttgttc aagataaaac agatttcatt tttatatctg 3374041 ttgacatgga tgtcttagac cagtcccatg cacccggctg tccagcgatt ggcccgggcg 3374101 gcctctatac agacgaattg cttgaagcag tcaagtacat cgcacaacag cccaatgttg 3374161 ccgggattga aattgttgaa gtcgacccta ccctcgattt tcgagatatg acaagcagag 3374221 ctgcagctca tgttctgtta cacgcattaa aaggaatgaa actctcccca ttcaagtgat 3374281 cttctggcag gttgtatttt gggtataaga aactcatctg cctaaggaat ggcagctaaa 3374341 aggagggcga gacagtgaat cttcaggaga acagcagcca acagctaaaa cgcacaatga 3374401 aaagcaggca cctatttatg atctcattgg gaggcgtcat aggcacagga cttttcctca 3374461 gtacgggcta tacgctacat caagccggac ccggcggtac gatactcgct tatgtaatcg 3374521 gcgggttgat gatgtacctc gtcatgcaat gtctcggcga attgtcggtt gccatgccgg 3374581 tgaccggctc ttttcaaaaa tatgctacaa catttatcgg tccatctacc ggttttatgg 3374641 tcggcatcat gtactggatc aattgggtgg tgacggtagg ctctgagttt accgcatccg 3374701 gtattctcat gcagcgctgg ttccctgaca gcagtgtatg gatgtggagt gcgatttttg 3374761 cagcccttct ttttatatgc aacgcatttt cagttaagtt atttgcggaa actgaatttt 3374821 ggttttccag cgtaaagatt gtcaccatta ttttatttat cattttagga ggagccgcca 3374881 tgtttggcct gatctcttta aacggaacgg cggatgctcc tatgttgtca aacttcacag 3374941 atcatggcgg gttgtttcca aatggctttc tcgccgtttt tatcgcgatg atatctgtga 3375001 gcttcgcctt ttccggtaca gagttaatcg gcgttacagc aggagaatca gcaaatcctc 3375061 aaaaggatat accgcgatcc atccgtaatg tcgcatggag aaccgtgatt tttttcattg 3375121 gcgctgtctt catattatcc gggttgattt catggaagga cgcaggcgtg attgaaagcc 3375181 cgtttgtcgc cgtatttgcg gagatcggaa ttccttacgc tgctgatatt atgaatttcg 3375241 taatattaac agccttgctg tctgtcgcca actcaggctt atatgcttcg acccgtatga 3375301 tgtggtcttt agcaaatgaa aacatgatca gctcccgttt taagaaagtg acatctaaag 3375361 gcattccttt aaatgcctta atgatcagta tggctgtatc ttgtttatct ctcgtttcca 3375421 gtatcgtggc ccctggaact gtctatgtgg tgatggtcgc aattgctgga tttgcaggag 3375481 tcgtggtctg gatgagcatt gccttgtccc aactcttgtt tcgaaagaga tttttgaaaa 3375541 aaggggggga tgtaaaagat ctgacatttc gcacgccgct ttatcctctt atgcctatag 3375601 ccgctctctt attatgttct gcttcttgta tcggtcttgc ttttgatccc aatcaaagaa 3375661 tcgcactttt ctgcggagtt ccttgtatca tcctttgcta tctcatctac catttcaaaa 3375721 gaaatgttac aaaagcgaaa aaaatcagcc aagaggaata tccagccgat cacatcctat 3375781 aattaaaaaa gcacaccccg ctcagcatgg gatgtgcttt attttttatt ctgtaattaa 3375841 cgtatgaatc agcttcggcg ccttcgcttc cgcggcgatg cggatgttgt catagacttt 3375901 tgcgatgact tcatcgacgt tttctcggtt agcgtaaagc gttacgagcg gttccccttt 3375961 ttctactttg tcgccgacct ttttgcggag catgatgccg acggctaaat cgatttcgtc 3376021 ttcttttgtg gcgcggccgg cacctaacag catcgccgcg acgccgattt cgtccgcgac 3376081 gatttcagag acgacacccg cttctttggc aggcacatca atttgatatg cggcttgcgg 3376141 aagcttagac ggatcgtcaa caattgagct gtcgccgcct tggtttttca ggaaatcctt 3376201 gaatttctca agtgctttgc cgtttttcat gacttcttcc agcttcgctc tcgcttcgtc 3376261 caatgtatcg gcttttttcg caagcacaac catctggctg ccgagcgtta agacaagctc 3376321 atgaagatcc tcaggcccct cgcctttgag cgtgtcgatc gcttctttga cttcaagcgc 3376381 atttccgatc gcaaagccga gtggctggga catgtctgaa atgacagcca ttgtttgacg 3376441 gccgacgtta tttccgatgc gtaccatcgc tttggcaagt tcagctgcgt cttcttctgt 3376501 tttcatgaag gcgcccgctc ccgtttttac gtcaagcacg atggcgtccg ccccggcagc 3376561 gatttttttg ctcataatcg agcttgcaat gagcggaatg gaattgaccg ttcccgttac 3376621 atcacgaagc gcgtacagtt ttttatcagc cggcgttaaa ttgccgcttt ggccgatgac 3376681 cgcaaccttg tcgcggttca caagtttaat aaattcatcc ttcgtcagtt ccacgtggaa 3376741 gcccatgatt gcctctaact tatcaatcgt gccgcccgta tggccgaggc cgcggccgga 3376801 catcttagca accggcacat caagagccgc aacaagcgga gcgagaacga gcgttgtcgt 3376861 gtcgccgacg ccgccggtag agtgtttatc cactttaatt ccttcaatgg cagaaagatc 3376921 aatcgtttca ccggagttca ccatagccat cgtcaagtcc gcgcgttcac ggtcactcat 3376981 atcctggaag aaaatcgcca tagcaagcgc gcttgcctga taatcaggaa tgcttccatc 3377041 tgtatagccg ttcacaaaaa attgaatttc ttcagtggtg agttcttttc cgttttgttt 3377101 tttgatgatg atatctacca ttctcatgtt tggtcaccga tccttttcga ttaagttcag 3377161 taaatcaagc ccacaattgc tgctgataaa aagctgacaa gcgtagcacc gtataataat 3377221 ttcaagccga aacgagcgac gacatttcct tgcttttcat tcagtccttt tacggcaccg 3377281 gcaatgattc cgattgagga gaagttcgca aatgacacaa ggaataccga tacgatcgct 3377341 gttgtacggc cgctgaaatg gaaaccgttt tgcgtaagcg acgtcatggc gacaaattca 3377401 ttcgatacca tttttgttgc cataatgctt cccgcattaa cagcttcatt ccatgggata 3377461 ccgacaagaa aagcgaatgg agcaaacaca tatccaagaa tgccttggaa cgaaataccg 3377521 aatactgcat taaaaatgcc attgatcaat gcaataatcg cgacaaatcc aatcagcatc 3377581 gcagcgacga caaccgctac tttgaaaccg tcaagaatgt attctccgag cacttcgaag 3377641 aaggattgtt tttcttcttc ctcaacacga agcatatcct cttcttttgc aacctcgtac 3377701 ggattgataa tagaagcgat aatgaaaccg ccaaataagt tcaaaacaag cgctgttaca 3377761 acatattccg gtttcagcat tgtcatatac gcaccgacaa tcgacattga tacagttgac 3377821 atcgcagatg cgcaaagcgt gtacaagcgc tgctgattta aaagaccgag ttctttcttc 3377881 aaggagataa atacttctga ctgccctaaa atcgcagaag ccactgcgtt atacgattcc 3377941 aatcttccca taccgtttac cttgctgagg gcaaggccga tatatctaat gataaacggg 3378001 aggactttcc acttttgcag aatcccgatc agagcggaaa taaacacgat tggcaagaga 3378061 acattcataa agaatgtcgt ttggtccgca ttcaccaagc cgccaaacac aaagttaatt 3378121 ccctctgccg cgtattcaag caggtaaccg aatccttttg caaatcctcc cacgaggaaa 3378181 ttccctattc cggtattgag gagaatgtag ccaagaataa attgcaaaat gagcataaca 3378241 acaattgggc ggatcttaat tctttttttg ccgctgctcg cgatccacgc gaggcctaaa 3378301 aacacgatta aaccgataat cccaatcaaa tacttcatat gtgtttctcc tttatttgta 3378361 ttcgcttaca attactgttt cctcagaaaa cggaaagcag tctgccttcc gtcagctctt 3378421 aatagttgtc tccgcctgat gcattttctc cttttacgat agaaacgcct gcgctggcgc 3378481 caattcggct tgctccggcc tctaccattg tgtctacatc ttctttcgtt ctgacgccgc 3378541 cagatgcttt cacgccgata tcaggcccta ctgttttgcg cattaaggcg atatcttcct 3378601 tcgttgcgcc gcctgtagaa aagcctgttg atgtttttac gaaatccgct cccgcagaca 3378661 ccgctaaacg gcatgcacgt tctttttctt catcagtcag aaggcacgtt tcgataatga 3378721 ctttgacaag cgcttttccg gctacagctt ccactacacc gcggatatca gcttccacca 3378781 catcgtcttc cttgtctttt aaagcggcaa tattaatgac catatccact tcagtggcgc 3378841 cttttgaaat ggcgtctttt gtttcgaacg cttttgtttc agttgtattg gcaccgagcg 3378901 ggaagccgat gaccgtacaa acgtcgactc cagttccctt aagctctttt gcagcaagct 3378961 ccacccatgt cggattgaca catactgaag caaatttgta tgttttcgct tcttcaatta 3379021 gttttagaat gtccgctttt tgtgtatgcg gtttcaaagc tgtatgatca attatgttgg 3379081 ctaatgacat ccttcgcaca cttccttttt tgttaagata ttttttagca taaccgactt 3379141 ttgaacatat gtaaattggt aattgaaatt ttgttcaatg aaaggtttga acgtgtcaca 3379201 aatcattaac aagcgccctc gcggtatgct ggtcaatgat taaaacgttg gcatattttc 3379261 cggttaatgc tccgtgaatg gaagatactt ttctgcttcc gccggcaact aaaatggagc 3379321 gttccttcag tctaaggtct tgaagctcaa caccgatggt ccggtcattg atggcgctgc 3379381 tgcaaatatt ccctttcgca tcaaaaaagc gtgaacaaat atccccgacg gcctgttttt 3379441 tcagcagggc tttctcttct tcgttaaaat atccgagccg aaacaacagc gcttcatcac 3379501 ggacagtccc gaccgtaaag agagcgatat tcgcctgctt gcccatctca atgatccgtt 3379561 caatatgacg gtctttctcc accattcgct tcacatccgc attatcaaac acgacgggaa 3379621 gcgggagata gcgcggcatc gtttgaaaag cctctgcaaa cagctgaatc gtttcagccg 3379681 aatacgtgtt tacccgggaa tggctgatgc cgcctttcag ctggacgacc tcgacgcctt 3379741 ttacctgctt cggctgcatg ttttgcgcga tttgatacat ggtggttccc cagctgacgc 3379801 cgacaatgtc gccgtctttt accgtttcat gcatatattc tgcaccatag cggcttaggt 3379861 catgtgtaat tcctgcataa tcgggtgtcg gggaaaacac aacatgcgcc tcaaggagcc 3379921 cgtatttctc ttcaagtatg gaaccgagcg catccaaatc ctcaaaaggg tccatgacgc 3379981 gaatctggac ataccctttt tcctttgcat attgcagcag ccgggaaacg gttggccttg 3380041 aaatgttgag ctgctcagca atttgctgct gactgtagtc agactgatag taaagccttg 3380101 ccgcttctat gcttaattgc tgtttttccc gatccattct gcacctccct gtggatcagt 3380161 cctgataaaa ctgcttttga tttgctttta ttatacaggc tggcgccggc tttcatccac 3380221 ctgatttcta agaaactgaa aaacgctctg ggcgcggacc tgcccagagc ttacttctcc 3380281 caagtcggtt tctctgagca taaagttatt tcgtttttcc taaactcagc ggatctgtga 3380341 tcatctcttt tggctataaa gtttccgttt tttcaaaaca aatgtttcaa atgagatagg 3380401 aaatgggtac taatctatta actttgttac atatttttag atactcattg gctcaacaac 3380461 tgaggaggag acatttgtga agaaagacac aaggaaatat atgatctact ttttcggcgc 3380521 tttaggggga ctgctatatg gttacgatac aggtgttatc tccggagcac tcctgtttat 3380581 caataacgat attcctttaa cgacattgac agaaggattg gttgtcagca tgctgctcct 3380641 tggcgcgatt ttcggttctg ccttgagcgg cacatgctca gaccgctggg gcaggagaaa 3380701 ggttgtattt gtcctttcca tcatttttat tatcggtgcg ctcgcttgcg cattttctca 3380761 aacaatcggc atgctgattg catctagggt gatactcggg ttggccgtcg gcggttcaac 3380821 ggcacttgtg cccgtgtatc tttccgaaat ggcaccgacg aaaattcgcg ggacactcgg 3380881 cacaatgaac aacttaatga ttgtcaccgg gattttgctc gcctatatcg ttaactacct 3380941 gttcacaccg tttgaagcgt ggcgctggat ggtcggtctg gctgcagtgc ctgccgtgct 3381001 tctattaatc ggcatcgcct tcatgccgga atcgccaaga tggctcgtga agcgcggcag 3381061 cgaagaagaa gcgagacgca tcatgaacat cactcatgac cccaaagaca tcgaaatgga 3381121 attggcagag atgaagcaag gggaagcgga gaaaaaagaa acgacacttg gcgtgctgaa 3381181 agccaagtgg attcgcccta tgcttctgat tggcgtcggc cttgccattt tccagcaggc 3381241 agtcggcatt aacacggtca tctactacgc gccaaccatt tttacgaagg ccggtcttgg 3381301 cacatcagct tcggcgctcg gcacaatggg aatcggcatc ctcaacgtca tcatgtgtat 3381361 cactgccatg atcttaattg accgtgtcgg ccgcaaaaaa cttctgatct ggggaagtgt 3381421 cggcatcaca ctgagccttg ctgctttatc aggcgtgctc ctgacactgg ggctttccgc 3381481 atcaacagcg tggatgacag tagtctttct cggtgtctat atcgtctttt accaggcgac 3381541 atggggtccg gtagtgtggg tgctcatgcc tgagctcttc ccgtccaaag cacgcggagc 3381601 cgcgacaggg ttcacgactt tggtgttatc ggcggctaac ctgatcgtgt cgcttgtctt 3381661 cccgctgatg ctaagcgcga tgggcatcgc atgggtcttt atggttttct cagtcatttg 3381721 tcttctctca tttttcttcg cgttctacat ggtaccggaa accaaaggga aaagcttgga 3381781 ggaaattgaa gcaagcctga aaaaacggtt taaaaagaag aaaagcaccc aaaaccaagt 3381841 gctgaatgag cgtacattat aaaaaaagga atcgtctcct tatgagacga ttcctttttc 3381901 tgtttacacc atgaccttgc aaatattgtt cgtaaattcc acagggtcct gaatcggcag 3381961 gccttcgatg aggagcgcct gattgtacag aaggtttgtg tacaggctca gcttctcttt 3382021 atcttgttca aacgcgtcct gcagtgtttg gaatacctcg tgatttgggt tgatttccag 3382081 cactttttcc gccttcacat tttggctgtc aggcatcgca tttaagattt tttccatctc 3382141 aattgtcact tcgccgtcag cagcaaggca gactggatgt gatttaagcc gttttgagat 3382201 tctgacgttt ttcactttgt ctgacagaat gtttttcatt tcctcaaaca gatccttata 3382261 cttgctttcc tcttcctcgg actgcttttg atcctcatcc gtgtctatgc caaggtctcc 3382321 gcttgatacg gacttgaatt ctttttcctg ataagaagcc agcattttaa ttgcaaactc 3382381 atcgatgtcc tcagtaaagt agaggatttc atagcctttg tccgccacca tttccgtttg 3382441 cggcagtttc tcaatgcggt cgtaagaatc accggtcgcg taataaatga atttctgctc 3382501 ctctggcatt ctggaaacat actcgtctaa gctgaccagt tttttctctt ttgaagagta 3382561 gaataagagg agatccttca attgatcctt attcgcgcca aaatcattgt acacgccgaa 3382621 tttcagctgt ctgccgaacg acttgtagaa cgtctcgtat ttctcgcggt cttttttcaa 3382681 caggctttgc agctcgcttt tgattttctt gctgatgttt ttcgcgatca gcttcagctg 3382741 gcggtcatgc tgcagcattt ctctggaaat attcagcgac agatcctcag aatcgaccat 3382801 gcccttcaca aagctgaagt ggtccggtag caggtctgcg cacttattca tgatcagcac 3382861 gccattggaa tacagctcca agcctttctc atattccttg gaatagtagt caaacggcat 3382921 gttttcaggg acgaatagaa tcgcgttgta gcgaaccgct ccatccacgc tgatatgaac 3382981 gtgtgtcagc ggtttatcaa acccgtaatg cttttcagca tagaattttt cataatcctc 3383041 atctgtcagc tcgcttttgt tttttctcca gatcggcacc atgctgttga ccgtctgctc 3383101 ttcctgcacc tcttcaaatt cattttcgct gccttccttc ggcttattaa tggttgtatc 3383161 cattttgatc gggtagcgaa tgaagtcgga gtacttcttg atgatcgctt ttaaacgata 3383221 ttcctctaaa aactcgtcat agctgtcatc ttctgtgttc tctttgattt tcaggataat 3383281 gtctgtaccg acagaatcct tttcacacgg ctcaatcgta tagccgtctg cacccgcaga 3383341 ctcccattta taagcctctt cgctgccaag cgctttactg atgactgtca cgacatcggc 3383401 aaccataaat gccgcgtaaa aaccgacacc gaactgcccg ataatgtcat gtccgtcttt 3383461 cagctcgttt tcctttttaa acgcgaggga accgcttttt gcaattgttc caagatgctg 3383521 ttcaagctca tcctttgtca ttccgatccc cgtatcagag atggttaatg ttctcgcatc 3383581 tttgtcagct gcgaccttta tgtagtaact gtctttatca aacgtaagcg catcgtccgt 3383641 aagcgctttg taatagattt tgtcaatcgc atcactcgaa ttggagatta actcgcgcag 3383701 gaaaatttct ttttgggtat aaatggagtt aatcatcata tccagcaagc gtttagactc 3383761 tgctttaaac tcttttttcg ccactcttga tcgctccttt accattatgt aaaccctttt 3383821 cagcatctat ttatcacata agatgacaat tgtcaattag attgatagat gcatatatat 3383881 gtaaatttaa cattagttgg atttgttttc actctttttc tcactcattc tcataaaaaa 3383941 gagaggcttc atcatcctct ctttttttct gtgtcattcc aacggccaaa ctcccgcttc 3384001 atccatatat gcaccgggta gaaaaacaaa ccgaacggta tcaaaaacaa aagattatgc 3384061 catgaagcat tcagaaatgc gcttgcagtc accgggaacg taatctcttg caataaaaaa 3384121 gagatgacag tcagcacaac aaatgcagat ggaatggtca cgatgcaata aaacttgagc 3384181 tccttcttat gctgtacctt caaacataca aacctcccaa caatttctaa ttcatcttaa 3384241 catatgctgg cctttctttt ctcgcatgtt tatcactgca catagcggga agacaaatag 3384301 aaaaaggagg tctcgtatca tgggaagact tgaaaacaaa acagcagtta tcacaggcgc 3384361 cgcgacaggc attggtcaag cgacggcgga ggtttttgcc aatgaaggcg cgcgtgtgat 3384421 catcggagat atcaataaag atcaaatgga agaaacagtt gacgcaatca gaaaaaacgg 3384481 aggacaggcc gaatcctttc acctcgatgt gtcagatgaa aacagtgtga aagcatttgc 3384541 tgatcaaatc aaggatgcat gcggaacgat tgatattctg tttaataatg ccggcgttga 3384601 tcaggaaggc ggaaaggtgc acgaatatcc ggttgacctg tttgaccgca ttatcgccgt 3384661 cgacctgcgc ggcacattcc tttgcagcaa atatttgatt ccgctcatgc tcgaaaatgg 3384721 aggctccatc atcaacacct cctccatgtc aggccgtgcc gcggaccttg accgctccgg 3384781 ctacaacgcc gcaaaaggcg gtatcaccaa cctgacaaag gcaatggcaa tcgactacgc 3384841 acgaaacggc atccgcgtca attccatttc accgggcacg atcgaaacac cgctgattga 3384901 caaattagca ggcacaaaag aacaggaaat gggcgaacaa ttccgcgaag ccaacaaatg 3384961 gatcacgccg ctcggacgtc ttggccagcc caaagaaatg gcaacagtgg cactgttcct 3385021 cgcatcagac gacagctcat acgtcacagg agaagacatc accgcagacg gcggcatcat 3385081 ggcgtacaca tggcctggga agatgctgat tgaggagaaa tggaaggaag aaacgaaata 3385141 agagagggag ccccctctct ttttgtcttt taaagcaata caaccttata tttcttcaca 3385201 tccaaaaact gcaaaaactc cctcgccagc acttcaggcg gatgcgcctt tccttcatcc 3385261 agccgataca aaagcaaccc gataatcatt gcggatacat aatgggcata aagctttttc 3385321 tctgcgtgaa tatcagtttg ctgatgcaga taaaacgatt ccagcgcttt gaacatatca 3385381 ggtatcacat gaggaacacc ccattcccga ttgagaaaat ggacaatggg catgtttgac 3385441 aaagcagaaa gcagaatggc gagcgccttc tccgcttcct ttaaggaaaa ttcattcggg 3385501 ctggaggcaa tcgtcaggtg atcaatgatc tccgcacatg atcgctgtat catggtttgg 3385561 agcaattcct ccttattggc atagtgatca taaaaggttg cacggcggat attgctttta 3385621 cgcgtaatat ctgaaatcgt gatgcccgcg tagtcttgtt tctccgccaa tacatccaga 3385681 aatgccttct gcagcgcctc tctcgttcga accacccgcc tgtcgatttg cttctccttc 3385741 tctcgctctc ctggcacagc ttttccaaac agccaataaa accgcttttg agaaacaagc 3385801 tcccatacct tctggctgat ggcttcagga gacgcggccg catcctcatt cagccaatac 3385861 aggataatcg cgtacgtgta caaggcccga taatgtccat aaatgtcccg ttcaatcggc 3385921 gttaaattca catggatcgg agccagcagc acatcctgct gaaacacatc cttaaaaaaa 3385981 cgatgaaaat gtcctctgtt catcatcaca gaaaaaaagg aacgatgctc atgaacaaag 3386041 gacagcgtcg gatgcaccgt ttgccgtttt ttgttcaaat gaagggtatc catatgactg 3386101 aaggcgtcaa aaagcgcttt gcccagtcct tccttcatgt cttcgatcac atcctcaatg 3386161 attgaaaact tatcctcata ataaaggtag agcgatccgc ggctcacttt ggccttctca 3386221 gcgatttctt tcattgtgat gtgttgaata tctctatctt tcaataaagc cagcagcgcc 3386281 tctttcactt gagcttcggc agattccggc acaaaagaca cctccaatca ttagacagat 3386341 cttagatata tgtacggtaa cgtatagatg gttcaccgtt gtctttctta cagaaaaggt 3386401 accaccttat aataggtccg agaaaagaag aaagcaaatg agggggattt tacaatggaa 3386461 cagcaagtaa aggacgacat ccagcgtgtc tttcagcttc agaaaaaaca gcaaaaagcc 3386521 ttgcgcgctt caacagcgga acagcggaga gaaaagcttc aacgcttttt agattccgtc 3386581 atcgcccatg aagaagaaat catcgaagcg atccgcaaag acgtccgcaa accatatcac 3386641 gaagtcaaaa aagcggaaat cgaaggaaca aaaaaagcga ttagagataa tatgaataac 3386701 ctggaacaat ggatggcgcc taaagaagtc ggttcatcgt taagccctga cgcaaacgga 3386761 attcttatgt acgagcctaa aggcgtcaca ctcatcctcg gcccgtggaa ctatccgttt 3386821 atgctgacga tggcgccgct tgccgcttct ctcgcagccg gaaacagcgc gattgtgaag 3386881 ctgtccgatt tcacgatgaa cacgagcaac attgctgcta aagtaataag agacgctttt 3386941 gatgaaaaag aagtcgcgat ttttgaagga gaggttgagg tggcaaccga actacttgat 3387001 cagccgttcg accatatttt cttcactgga agcacaaatg tcgggaaaat tgtcatgaca 3387061 gcggctgcca aacacttggc atctgtcaca cttgagcttg gcggcaagag cccgacgatc 3387121 attgacagtg aatacgatct gatggacgca gcgaaaaaga tcgccgtcgg gaaattcgta 3387181 aacgccggcc aaacctgcat cgcacctgat tacctgttca ttaaaaaaga cgttcaggac 3387241 aggttcgcgg ggattttaca aacagtcgtc aacgctggat ttatggagga tgatcatacc 3387301 ccagaccgca gcaaatttac gcagatcgtc aatgaccgca acttcaaccg cgtcaaagat 3387361 ctgttcgacg atgccatcga aagaggggcg gaagtggtgt tcggcggcgt attcgatgcc 3387421 agcgaccgca cgatctcgcc aaccgttttg aaaaacgtca cgcctgacat gaaaatcatg 3387481 caggaggaaa tcttcgcatc gatcctgcca atgatgaact atgaagacat cgacgaggtc 3387541 atcgattacg taaatgaccg cgataaaccg cttgcacttt atgtgttcag caaaaaccaa 3387601 gatctgattg acaacgtcct tcagcacacg acatcaggaa atgccgccat caatgatgtc 3387661 gtcgtccatt tcagtgacgt caacctgcca ttcggcggcg tcaacacaag cggaatcggc 3387721 tcctatcatg gggtatacgg attcaaagag ttttctcatg agaagggtgt atttattcag 3387781 gccgctgaat aatcgcatga tcaaaaggcg cttccttaga ggagcgcctt ttattgtaac 3387841 tccttgacca aaagcaattc atcacggata ggtattttat tatctgccag taaaggaatt 3387901 tcgggcttca tctttctggc cgtctcgact gcattcacaa atagtcgatc caaccggtac 3387961 cctctcttct gataaaacgc taatgcatga atattatcat tggttgtgat cagttttatt 3388021 tgtttgatat ttctctctct gcatgcttcc tcggctttct ctagcagagc tgttccgatc 3388081 cctttattct caatgacact atccagcgaa atgatttcac aggcatcttc ttcaaatatg 3388141 tatgtaataa ggccaacaat ctggttatca tcgttgagca ttccataacc atctaattca 3388201 tcgcagttat aaataccgct agaaataacc atttgcggac tgccccagtg tttttgaaaa 3388261 aacgcggaaa caagatcttt aggtacctgg catgtcggaa taatattcat attttcctcc 3388321 ttttagctga acaaaaataa gagaattaac aacctatttt atgtcattaa tccccttatc 3388381 tagtatttac tagaacttat aacttgtcaa aagctgtctg aataccaatt gcgtggattg 3388441 ataaggatca aaatctgaat cctgagattg gaagatttgc tctggggtca atgtctctgc 3388501 gttctctgat aacgtttgaa tcagactttc caaatatcca tttaactctg atttggacga 3388561 ttcatgtagg gattgatgat ttacagcgag ttctctaaat ctgttatcac tgattaattt 3388621 ttttcgaaga gctgctagca tcaagtcaag ccatgcaggc tggccaaatg taatatttaa 3388681 agctaacgtt gcttgatcag atttggtgga gtgccataaa cctcttggca aatacagcat 3388741 ggttcccggt gttaaattaa cgatttctgc atctggcaga tcctcttttg gcggatctcc 3388801 tttccaatat gactgtaaat catcaggata gtaaggagcc tctgataaat catagtgctg 3388861 cattggattg ctcacatttt cattcttggc aagcttccat gttttctcac cttgaatttg 3388921 aaaaatcaag ttggtgtagg cgtcaaaatg ggctttgaat cccccgccat ttttcgccgc 3388981 gtaaacaatg gctttggaag aagtacccgc aggcagtctt aattccgctt tgagtttttc 3389041 tatccacctt ctgacttggg gaataaatag gtcggtgaaa tcaaactcta atgcagcccc 3389101 tttttcatac cactctaaag cctctgcagg tgacacaaga aatctgtctg tgatcccttc 3389161 agattcttca atcacagcat caccaacgac catgactgga ttattgtaga tagccaatac 3389221 gttttctagc gttctaacct tttcaaaccc cggtatgctt gtaaatctct ccacttctcc 3389281 tctggctacc aaaggtttta caggccaata ttcttctaaa aactcactca tcgttacagg 3389341 actgatgata gactccaaaa ccgattcggt tacagcactc atattatccc tcccaaaaaa 3389401 agtaacttca ccacaaagat ataacatttt tttctaaaag taaatattga cagaattatc 3389461 agaggattat aatatttagt tgtgcgtgat agcctatttt tttacaagga aggagggaaa 3389521 aggatgaaaa aggcttataa gaaacctcgt ctttttgaac tgcgccgtgc tgtagcagct 3389581 ggcggccatt aatctcatat agcatttgac atctagtact ctattttagg agggatgctc 3389641 aatgaaaaaa gcttataaga aacctcgcct ttttgaactg cgccgtgctg tagcagctgg 3389701 cggccattaa tctcatatag catttgacat ctagtactct attttaggag ggatgctcaa 3389761 tgaaaaaagc ttataagaaa cctcgccttt ttgaattgcg ccgcgctgta gcagctggcg 3389821 gtcattaatc ttatccaaaa cgattaacgt ttgaggctat cacgccaact tgataaggag 3389881 gatgctgaag atgattacgg ctgaagaatg cagaacgtac aaagaatttg ttgatcttta 3389941 ccaatcctat ctttacccct tgcttggcgc cagactgtcc cggatgtatt cccccaaaaa 3390001 caaagtcatt atcgatatgg gcacaggtcc aggttattta agcattcagt tggctaaaag 3390061 aacaaatgcg cacgtgcatg ctgtcgatat taacccggcc atgcatgaaa tcgctcaaga 3390121 agaagctaaa aaaagcggag taagcagcct gatttcattt gatttggaag atgtccacca 3390181 tttatcttac gctgaccaat atgctgactt catcgtctcc tactcttgcc tgcatcattg 3390241 ggaagacgtt gttaaaggac ttaaagagtg ctatagagtt ctggctccgg gcggaaaaat 3390301 tgtcattttg gatacattta atccccaagg aagccattta gagattatgc gaaaacaaat 3390361 caaagaaccg gaatacttca ggtttgtaag agaggcattt gaagaaagtt attcctttga 3390421 agacattcac cagtttgttc aggatgccgg cattcccaat tattcattag aaacctttca 3390481 ctttttaccg gaggatttta tagaaagctt agatgagctg gaggatgctc ccctgtggga 3390541 acaaaatgat caaagtactg atcatgaaat tgagtctgtc acatggatgt taacgataga 3390601 aaaagaaaag gaaggtgcat tgtaatgatc aatgaatcaa ctgttttatc caaaaatcca 3390661 gaaatgccat caagaaaata tttgaaaagc attattatag agccgggcat cactttaaat 3390721 gaaatggcat cagatattta taaccatatc gacggcaagg tcagcataca tgatatttgc 3390781 tcaaaaatcg tcaatgaata tgatgttgat tatcaaacct gcttagaaga ttgtatggag 3390841 ctgtttgagt tgcttattga tcatgaagca atcaaagtta agcagggggc atgagaattg 3390901 gaaaaacaaa aagtgcttgc tttaccagac gatgtacatg agctgagtac acaccgttct 3390961 aaatcaatcg taaattacat catcactctg cttgcctttg ccaaaaaaca aggattgact 3391021 catcaagata ttgtaagctg gattcacgag caatatgagg aaagaggata ttatgatgag 3391081 tggagacaca ttaacagcca acaaccagtt ggatcatttg tggaactctt tataaaagga 3391141 agacgtttac tttatgacaa aattgaattg tttgaaacag aagataaata tgtcgtaaat 3391201 acccacactt ggtatgaaaa agaacctagt gaggcctttt tttattttga aattgatccc 3391261 gaagaatttt ctgcgtacgc ttccattctc gcaatcgaaa acgcaaaacg tctcggaatt 3391321 aaaatcgata ttgtaaaaga aacagatgta gagacagctt atatctataa acatcaataa 3391381 cgctattggg agggagacat atgtgcgggc tcgcgggtat tataaatctg gctgctcccc 3391441 gttctcagga atgtaccttt catatattga aaggcatggc agatgccatc agctataggg 3391501 gaccggatga tgaacaatat catattgatt ccaaagtcgg ctttgcattt cggcgattgt 3391561 ccattcttga ccttgtaaat ggacagcagc cctttttaaa tgaggatgga tcaatcgtcg 3391621 ttatggtaaa tggagaaatt tataactata aagaactgaa ggcttcttta cacaatcata 3391681 tgtttaaaac gacatctgat tgtgaagtaa ttgttcattt atatgaagaa aaagggattg 3391741 gatttgtaga cgacatcatc ggaatgtttt caatagccat ttgggacaaa aataaaaaca 3391801 aagtattttt agttcgtgac cgctttggga ttaaaccgct tttttacaca gagctaaaac 3391861 acgagcttat atttgcctct gaaataaaat ccctattttc tcatcctcac tgtccccgcc 3391921 aatttaattg gaaagaagca ctctcagaca tttggctaag cggggaagca gccagtaatc 3391981 ataaagaaac cacttccttt tttgtaaaca tccaaaatct cgatgctggc cattatctcg 3392041 aaattaattt gacaacaaat gaacgaaaaa cagcaagcta ttggtcttta caggatattt 3392101 tgctcaggca aggctatcgt gagaatctcc atcccgatga cctgattgaa ggatatagag 3392161 aactgctggc agattcagtc catagatgtt tacaaagcga cgttgaagtc gggttgtttc 3392221 ttagcggtgg cattgattca gctgcagtcg cacattttgc tgcagaaaaa caggatctcc 3392281 atacgtttac agtattaagc caaagtacat ttacaaatga agatgcaaaa tatgcccatt 3392341 ggctggctaa agatttacac cttccaaatc atcaggttct ctatcaatta gggaacgatg 3392401 agttattaca accagagtca tataaacatt tgttatggat ctgtgaaaca ccgttttgcg 3392461 gaccggaaca attatataag tttcatttac ataagtatgc caaagcgata aggccaaacc 3392521 tgaaagtcat gctgaccggc cagggcagcg acgaatttaa cggcggttac agcacgacac 3392581 tttcaccagc cgagaaccca agttgggaag gatttattga atcggtcaat acgatggaga 3392641 tgaaccggct gcatcggctg cagggaaata tctttagagt gtgggaggag cattttggac 3392701 tttctcctat aaacctttct tatttaaaga gcaatgattc cagccaagca gatccttggc 3392761 aatcgtatgt cctgacaaaa taccgtgatc tgcaaatgta taattgctgg catgaagatc 3392821 ggatcgccgc ggctaatcat atcgaaaacc gtgtaccgtt cttggaccat cggcttgttg 3392881 aatgggtttg cggaatacct gatggactcc gtaaagactt gttatgggat aagtcggtat 3392941 tgcgaaaatc attaacaaat gagctgcata caagctatac ccaccggcca aaggttcctt 3393001 ttttctatgg taaggacgtg agatatacac ataaaatgat gtttcatctt ctgaagaaaa 3393061 acaattatca gcttatagag gaggccttct ctcacagcga tgcctccagc ataatacagg 3393121 ttgaacacat tcatgccatc atgacatatt tggaggatga tcctgagttt acaaattttg 3393181 aatttttatt aagactggtg aacatgggac ttttatcaaa aatgactaaa gaaacccctt 3393241 ctgttcaatt agacataacc agccatttag aatcgataac aataaaagac tggcactcac 3393301 aggaaggtga tattgccagt cgtttaaata tctcagccaa taagtgtgaa ggacaagata 3393361 ttttggcgct aaaccctggc gtcactctgt taaggccgga aagcgatagt gagcattgca 3393421 tctacattgc ggaagaagga tttattcagt ttattgtttc ggaggaagac gtcggagctt 3393481 ggctgcatat tctctgcgat attaatggaa aagacacact tcatacgatt ttagacagac 3393541 atggtgtcag ccttgaagaa gtggccaaat atattcaaga agccatcgaa cacaatatca 3393601 ttttgatcaa acaaaaaaat ctgccagaag gagcatatag atgagcatct tttattcgtt 3393661 ttccgcactt aggggattag caatggggat tttttcgcct atttggattc tttatctgat 3393721 atctaaagat tatgatttcc ttcagattgg attaatggga gcggtacttg aaattgctaa 3393781 gcttatattt gaagttcctt ccggcgtttt tgctgatcgt tatggaatta aaatttcaat 3393841 tgccagttca ttctttttct ccatccttac atgggccttc ttccctttta tcgattcagc 3393901 tgctatttgc atactggcta tgatcatatg ggctttatca gattccttaa tttccggttc 3393961 ttttgaaact tggatgagcc gtgtcgcagg ggaagatcga ttcggcaaag aaatgatgaa 3394021 aaacacacaa ttgctaatca cttttttaat tattggaagt attgccagcg ggtatttgta 3394081 ttcattaaat atctattttc ctttcctgct cgttatggtg atctacttat tactatttat 3394141 ttggatgtct gtatttatta aagtcccttc tgtttccgaa acaaatcatg gggatcagaa 3394201 ccaacatgat tcgataaaga ttatcaaaga aagtttaaaa attatcttta acaaaaaaag 3394261 ggttctttta atcgtcatag ccggtttctt tacagccaca gcctatgaca caatttcccg 3394321 ttactggcag ccttttttga gtgatttagg cttttcagaa aagtcactgg gatatatttt 3394381 tgccctagga gggtttaccg ctctcgttct tttgacatta accatcaggt tcgaaaagaa 3394441 gatcgaaaaa aatccatatc tcgctttaac ctcattggat tccatgggca tggtcatgac 3394501 ttttctattg tctagagcat tcaggccgct gggcattcca tgtacagcgt ttttgcttgc 3394561 aattgaagat attcatcatc cgatcgtaac aagttactta aataagtttt tccccgattc 3394621 atacaagaac acacttttct cgttaaactc aggggtagga gcaattggag aaattctttc 3394681 cggtgtcatt ttcggcatca tttccgcagc ctttgggctc tctgccatgt ttgttgttgt 3394741 agctgtattt ctattaatcc ctattatcct ttatacgata gtgcctaaga ttaaagacaa 3394801 tgatatgaaa gttcagattg aaaaatccca gcaagtgtaa atgttttgta tcacagtaag 3394861 aagaccttct tattaaaaga aggtcttctg ctattctatt cagttatttc ccaaaagcca 3394921 tcagcttcgt ataacttcca atataaagtg ttccgtcctc agcgagctga ggagaagaca 3394981 cgacgttgct gtcggtttga tagctccata attcattgcc gtttgcgtct gccgcataaa 3395041 ccttcatatc atctgacccg aaataaaccg ttcccttcgc gtcaatcagc ggcgccgttc 3395101 tgacagggcc gtctgtgtag aatgaccagt tcatatcccc gtttttgctg atggaaaaca 3395161 gctcgccgct tcctgagccg atgtagatat tgccattatg atcaatcgca ggagatgagc 3395221 tggagaaccc gtttagcggg aatgtccatt tcaaactgcc tgttgatgta taagcataca 3395281 gctgtccatc ttggttgccg gcataaatgt ttccgtcctt atcaatcacc ggatatcctt 3395341 taaacgcatt tgacgtcgtt ctggaccatt tcacctgtcc ggttccggag ttgatcgcat 3395401 aaaacacgta attatatgtg ccgacataca cggtgccgtt tttggcaagc accggcacag 3395461 agctgacgac cccatttgtt ttcaacttcc agcgctctgt ccaggttgat tttgacgtcg 3395521 gtttgatcgc gtgaacataa ttatcaagtg ttgagaaata caacgtcccg tctgaaccga 3395581 tcaccgtttc agagcttggc ccgccgctta acggaaccgt tgttaaaatt tctcccgttt 3395641 ctttgtcaat aaaataaatc tttttgtcat aggatgccaa atagataacg ccgttggtcc 3395701 caagtacagg agattgcgta tatgtttttc caagattgcc cgtcacccat ttgactgagc 3395761 cgtctggatt aaaggctttc atttccccgt ctctggaatg aagatatact gtgccgtctc 3395821 cgtcaatcac agcccccgct ccattttgcg gagtcgttct gatgtcgttt tgccatttca 3395881 gcgtcccgtc tgtatttccg gcgaaccggc tttcgcgtga ccagttaaac atggcaggcg 3395941 ccatcgcttg tacatcatat cttcctggca aaaagccaga tgctccatta ttttgagaaa 3396001 acaccgtttc cgccgcataa gcagctgtcg gctgaagcac tttggcagcg ggcacatcag 3396061 aaacagcgcc ggccgaaaca gccgccgcca ccgcagctcc cgcaatcaaa gctttcatac 3396121 gaaatgactt gaccatcatt gagaccccca ttatatgtaa cttctaattt gtgaccatca 3396181 taacatattc atccatttta taaatctatt tcacaaaaac atcacaaact agaaaactat 3396241 gtaagagtat tcacggacgt tttttcagca cccgatcgaa atgcagccac aaaccaaatg 3396301 acgttgacag cagccgcagc gagactaact cccaaaacaa agatcacctc agaaagcaga 3396361 tggtcactaa agaaactaaa catcaagata aaaccggccg aagacaaatg aatcaaaagc 3396421 ccgaagccgc aaagcaccgc catgacatac ctcattgcat cgactccgag catataaacg 3396481 agaaatggaa tgaaatacaa gacaaggatc ataccgacag ctgaccacat gccagctgaa 3396541 ttaaactgat tggccgccgc tcccgttccg gccagcggcg aaagtgaagc cgccacaatc 3396601 acggcgcaaa aaagaaacgc agaaatggtt gtcatgatcg ccacgctatt tttttttgac 3396661 atcaaactcc tcctttaata gaaatattaa ccttttttat tataagtaag ttgaatgtta 3396721 tattcattat atttttaaaa aattccagaa tacatacaca aatgctatgc ttctttctag 3396781 tatatttata tagtaaaaaa caaaggataa aagactcatt tttctgtaat atcaggattt 3396841 tatcaccata ccatattgca tgtacatgtt tttcaaagta tactattcca gattaattca 3396901 gaggagagag aaaaatacat ggaaaaacca gcaggatttt ggattcgttt tttagcttat 3396961 tttattgacg gcattattgt atctgttcct agttatatta ttctatttat tatcaattct 3397021 gtgtttgtag ctggggctgt ggcaacaaac ccttacatga cggaagaaga gtatttagtg 3397081 aaatacatga cgcttgcatt tttgcctact atgctgatca tgatcgtcat cagcgtgtta 3397141 tattacgggc tgctcacagc ttctaaaatg caaggcacac ttggcaaaaa aattcttggc 3397201 ctgaaagtgg tcaatgaaca aggtgaacgg gtttctgtcg gacagggaat tggccgttac 3397261 tttgcctata tcttatctgg aatcatcttt tatatcgggt ttatcatgat cgcctttgga 3397321 gagaaaaaag gcctgcatga catcatttgc aaaacacgtg tcgtgtataa ataatagaaa 3397381 aaagtctaga cgccaatagg catctagact tttgttttct ttgcaatagg ctgccacgac 3397441 agatacgtag cgcttctcca caaccactca aacggcccca tccgaaagac acgaagccaa 3397501 aggtggctga agaccatttg aacggcacaa acagcaattg taatgagcac accggcagca 3397561 gggtacactt ttccatacag gcccaagccg taatgataaa aaatccaagt acacacaata 3397621 gactgcatca aataattggt aaatgccatc ctcccaacag cggagaatga ttgcagcact 3397681 gttctcactc ttgttttatg ataaagatag acaaccgttg taacatagaa aaacatgagg 3397741 aaaggcgcgc caatcagcaa acatatttct ttatccgtta cactgtacag cacctgggcg 3397801 ccgatgccga tgacaagccc agccatccat aatcgtttta atcctttgcg atgcttttcc 3397861 ggttcatgca aataccgtga ttttgctgcc gcagctccca gcaaaaacat gctgaaatat 3397921 ggaatggatg caaagaagta gttgagcgga ttatacgtaa gcatgccatt cgaagacatg 3397981 taaacaagac ggtcgtggat ccgctgttct gcaatatcct tcaggctgcc gcttccataa 3398041 acatgaatcg cttgttttgc ctgctgtgtt accgcttgta cccattcctg tccgtttgat 3398101 tgatcaaaac ttgtcaacat gaacggaatg gaaaacagaa gatacaaaga gaccgcccat 3398161 atcagcagtg ttttcggctt tgcttttcga aacaagagca ggacaaatcc gagcagggca 3398221 tattctgtta aaatatcccc gtcccatatc aaaaaggcat gaatcgttcc aaacaagaga 3398281 agcgccatta accttctcac atataacgga acaaaccgtt tccctttgtt ttctgctctc 3398341 tccatcatga caaccatgcc aaatccaaat aaaaaggaaa acaataaaat acattttgtt 3398401 tgaatgaaga atttcagtat gtctgcggcg gcaaaatcag cttcagacca cttatccatg 3398461 aaaaaattct cttttccaag catagacaaa tacatatccg gataactgaa atgtgccaga 3398521 ttgacaaata agatgccgaa aatcgccatt cctctcagca catcaagcac accgatccgc 3398581 tcatttgtta aagtcggctg taatgaagac atagccatca cgctcctttt ttctgtacct 3398641 taagggtagg aaaaaatgaa gcgcggtaac atcgatttag gtgtcaggcc ggcatgaaaa 3398701 ccttacaatc ttgtcatctt tatggtttca tcacctttaa atctaatgct tcgatattct 3398761 gcaaaatgcg atcaaagcgc aaagcctgag gctcacatgg gaagatgtgg ccttcatacg 3398821 ggtcgcctaa cgtccggaaa aacggttcaa ataaaccagg aaccaatacg cccaccatct 3398881 ttgtatagtg agaatcaagg cgataggagt gaacggtatt tgcagggaca tgcaggaaat 3398941 ctcccggatt cagctgaatt tcctggccat ctgtccacat cgtcatctgg ccttcaaggc 3399001 aataaaatgt ttctgtatga tattcatggt agtgatcaac gattcggtca cctttagggc 3399061 cttcagatga tacgacgata aactggccat ctgtattttt ttgtgcagcc acaatgcggt 3399121 gaagctgatc tccagtcaac agacgatctc cttctccaga ttcaagaacg tatggaaccg 3399181 ctccatctgg cagctctgta agttccgcta atttggccga acatgcaggc tttgcttcat 3399241 ctagaaatac aatgtccgct acagcggctg cttctgcaaa tcgctcgttt gagacttctt 3399301 cgcttgcgta cggcggatgt tcagcgtgat catacggatt cccaataacg gaatacaagt 3399361 gcgctacgtt tcctttcatc gtgtaagaca ccagtcttgt tctgtggctc tgcatccggt 3399421 agctgtgcgg tgttcccgcc ggaatgttgg cataatcacc tgatattaat aaatagcgtt 3399481 caccatcaag tgtcagttcc agtttcccgt ccaaaacgag aattccttca tgtgtgtcct 3399541 tgtggacgtg aagcggaaag gcatctcctt ttcccccgga aagaagcacg atctcaaaca 3399601 aatcacctgt gctcctccca ttcgccatca ccgtggcaac ctgtctgccg aacagatagc 3399661 gctcgccttc tccgctccgg agcaaataag gcattttttc tttaggcaat gaatgtgtac 3399721 ataatgtttt catattatcg cttcctccaa tttagaccag tctatatatt atcattcatt 3399781 tgtctagacc gttctatata attgtaggag aaaggataac aaaatgctac cctttttttc 3399841 tcaccagcac tggtatttgt tcggcaatga gaagaagagg cgttttgtct ttattcgtta 3399901 acgaaagcat gatgccgccc tcaatcatcg aattaatcag cgttccaagc tgatttgctt 3399961 cttcttctgc aaatccgttt tccattaatt ttctggcaaa aaccgcttcc cagcttttaa 3400021 acaccttcat gcaaaccgtc cgcagcggtt cactgattaa cgctgtctca ctcgccagca 3400081 aaccgactgg aataccttta atgctttctg tgttgtcaaa ttggctggct gtttttttga 3400141 taaaaagctg aatcgcttca acaggatcag aggattcatc catgctttgc tgtatcagat 3400201 gttcaacgat cttacctgta tatgtaaccg cttcaattgc tagttcttct ttgccattcg 3400261 gaaaaaagtg ataaagcgat ccttttggag caccgctttc ttttacaatc tggttcaaac 3400321 ctgtcgcgtg atatccttgc agctggaaca gacgtgacgc cgtgtgaagg attttttcac 3400381 gtgaatctcc tctgctagtc attaaaacat tccctcctag gtatggtaga gcgacttata 3400441 taatataaaa aagaaccctg tgattgtcaa aaggggtaag acccttccgg atggggtaat 3400501 gtacaaaaac agcgtctagg agggatctct caatgacaat cgatcattca gtcacaaata 3400561 cagagcagct tgaacaacag aaccccgcca taaaaacaaa gctcaaactg aaaaagctta 3400621 aggatcaggt gatcgtcatt accggcgctt caagcggtat cggacttgtc acggcgagaa 3400681 tggcagctga aaaaggcgca aaggtcgtgg cagcagcgcg aaatgaagag gcgctgaagg 3400741 agctcactga tgaacttaag gaaaaagggc acgacgccat atgggtaaag gcggatgtcg 3400801 gaaaagaaga ggacgtcaac cgcatcgcag aaaccgcgat cagcacattc ggccgctttg 3400861 atacatgggt caacaatgcg gccgtctcga ctttcggaca cgccatggac gtcaccgtcg 3400921 aagacatgaa gcgcatgttc gacacaaatt tctggggacc tgtttacgga acaagagcgg 3400981 ctgtcaaaca ctacaccggc agaggtgtgc cgggcgcact cattaatgta ggaagcctgt 3401041 tcggagacag gggaacggtc attcaatcca catatgcatc tgccaaattt gcgcttcacg 3401101 gctggacgga aagcatccga atggagcttg aaaaggaaca ggcgcccgtc tcggtaacgc 3401161 tcatccaccc gggcagaatt gacacaccat ataacgagca tgcgcacagc tacctcgaca 3401221 aacagccggc tcattaccgc tccatgatct atccgccgga agcggtcgcc gaagcgatcc 3401281 tgtttgccgc cgaacaccct aagcgcgaca tgtacatcgg ctcacaggcc aaagccatcg 3401341 ccatgctggg cgcgcttttt cctcgtctga ccgacagact gatggaaaaa atcatgtatc 3401401 acagccagca tgccgaaaga ccgtccaatc cgagagaaga aagcgctctt tatgatgctg 3401461 gctgcggtat gcatgacaga ggcacaaata aaggatggat gaggtcaaga agctactaca 3401521 caaaagcgac gaagcgccca attgtatcgg cggctgttgt tgccggacta gtggcttggg 3401581 ctgccgccaa acgatgcaga taatctctga ccataagaaa aacccatgct gttccagcga 3401641 accatgggtt tttcagctgt taatcgataa aagccttgtt catacgctgc agcagctcgc 3401701 cgaacatctc tttttcctgt gttgaccatt ctttcagcat ctgttcataa cgttcaaggc 3401761 gcttttgctg atcggctttt aatagttgtt tgccgagttt tgtaatggta aacaggctga 3401821 ctctcccatc agacgggtct gagaaacgat agatgagctc ctttgcctct aatgcagctg 3401881 cttgtcttga aagagtagaa atatcaagct taaacgattc agccaattcc ttaacacgag 3401941 caggcccaaa ctcatccaat tgtctcagta ataagtacga agatctctcc aaattccctg 3402001 ttcttttctc cgattgatcc agataaacag ctctcctgat aaaagtcgtc agctcatatt 3402061 caattaattc aactggattt tgattttgca atcgctctcg ctccctattc caatctccgg 3402121 cattgacaac atcatatata cttgtataat acaaatgtac attaactgaa taaatacaag 3402181 tcgttatatg actaaatcaa ttattatact tgtatagtac aatcatataa aaagaaagta 3402241 aagcgattcc tcagaaccat cctagaagca agcaccagaa aggaggaagc tgttctgatt 3402301 ggagagcagc acttgatgtg aaagtcatac gaattatttt gcaagtgttg atattatatg 3402361 tattttttat gatcggggaa gccattcagc atctgtttca tttacccgtg tcaggaagca 3402421 tcgttggatt ggtattgctt ctgatctgct tgggcctccg tattgttccc gtctccatca 3402481 ttgaagacgg agcagggttt ttattatcct tccttccatt gttgttcatc ccggcaatga 3402541 caggagtgat aaactatccg tctctcattt cattcaatgg cctgatgctg ctgattacag 3402601 tcgttctcag caccatcgtc acgatcattg cggctggatt cgccagccag ctattagaga 3402661 aaaaagcaaa aaaacgggag gagaaagaga aatgcagcaa gcatgtatcg cgatcattat 3402721 aattctttta acagttgccg cttatttagc gatggtcaaa ctctataagc gattcccgct 3402781 tccatttctg atccctgttc tgacaacgac aattttgatt gtagcggctt tgatgatgtt 3402841 tcatgtttcc tatgaaggct atatgatcgg ggggaaatgg atcaattctt tgcttgggcc 3402901 ggctgttgtg gcgctggcct atccgcttta taagcaatgg catatcattg tcaaacattg 3402961 tgttcccatt ttaggcggcg tcctggtcgg cttatgcatg ggaatgatca gcgggctgat 3403021 cttcgcagaa gcattcggga ttgatcatga tctcttatta tccattctgc caaaatcgat 3403081 cacaacccct gtcgctattc agatcgccgc cggtcttggc ggcgtccctt ccatgacagt 3403141 cgtatttgtc atgattgcgg gcttttcagg cgtcatcctc gggccgcttt tcctaaaatg 3403201 gcttcgcata cgcagctccc taggacaagg cattgcatta ggcagcgcct cccatgcact 3403261 gggtacctcc aaagcgttgg aatatgggga attggccgta tccatgagtt ccgtctccat 3403321 gacgctttgt gcggtgctcg gctcattctt cggcccgctc gtcgtctggc tgtttcatat 3403381 ttaacaaaga aagactgccc cgggggaggg cagtcttttt cgtttaagaa gcaaaaaaat 3403441 caatcaacgg ctgaaagtcc ttagataaat caacgtcatt cggttctgct tgaagcaggc 3403501 ggtcaatcat acgctccagc tcctcaacat cattcttatc cgtatattca atgaagttta 3403561 agctttcaag ccaatcccga tatgaatgtt tggctttgcc atagctgttt ccaaagacaa 3403621 ggcaaggtgt tttggtgata atcgagaaaa tcatcgcgtg aaggcggtcg gtaatcacca 3403681 atttactgga gccgatgcgg tccagcatct ccataaaatg cttttcacga tcagcgtaat 3403741 cgatggtgtc taccgtatcc agcaccgtat cggtacgctc tgtgtaagtt gttttttctg 3403801 cccattgctt catctgtgaa ataaaatctt cgtcagtcac tttctcctta tccgctctta 3403861 aaataaagag aacgccgtcc cgctcgagct ctcgcggcac aatatccaag gaaagcacca 3403921 tgtccggtgt aaagatcaca ttggagttga aggtctcttt cacaacatcc agtgtttgcg 3403981 tctcacgcgc agcaatcgtt aagtttgtat tttgatggta cgcatcctgt gtttttttct 3404041 tttccttctg tccttcctct gtatcctcaa aataaacgga ttgtggcaga gaaattgatt 3404101 tgtagtcttt aaacgccgaa aagacctttc ttctgtcttc ctcaatatcg agataaaggt 3404161 ttcctaaatt ccctccgcct gtaaagcaga caatatcgtc ttcacgaatg atctccttca 3404221 ccagttcaat gccctcatcc gtcgcataat ccataatctc aatgtattca taatacggaa 3404281 aatgattttt gataaatttc tcttccgcat acgcaatcgc ttggtcgcca atgtttgtgt 3404341 agctagggga accaaacaaa aatacttttc gtttatcatt taacagagct tccggctcca 3404401 catttggcgc aatgcctttt actagttttt tgcctttgat ttcttgtaca gtcatatctg 3404461 cgtcctcctt ctgggatgaa ttcctcattg tgtgttaact gtctctaccc aaaaagaagg 3404521 atggctatgc attggcatgt gcatcggcta tatcagaaac atcgttttcg ccaatttgat 3404581 agacgctgca atgtcccgcg ccgttctttc catatattcc gcggcatgtt caaacgcgtc 3404641 ttctagtggc acggctccgg ggacgatgct gaaaagcgca tcgattccgt gttgatagac 3404701 ggcattactg tctcgggaaa ttgatcccgc aatgccgata acgggcacat cgtatgattt 3404761 agcggccttg gccaccccga tcggtgtttt tccatgaacc gtttggctgt cgattcgtcc 3404821 ctcgccggta atcacaaggt ctgcatcctg aacgatactt tcaaaatcaa ccgcttcaag 3404881 gacaatatca atgcctcttt tcaggtcagc ctgaagataa gttagcaggc tccatccaag 3404941 accgcccgct gcaccggcgc cctctgtatc tcggaaggtt gatccgagcg ctttttctgc 3405001 catatcagcg aaatggctta cgttctggtc tagtacatcc aacatgtcgg ccgtcgcgcc 3405061 tttttgcggc ccgaaaacag ccgtagcacc ctttggtcct gttaacggat tgtccacgtc 3405121 acaggcaact tccagtttga cattccgcaa tctggaatca agcccgctca catctattga 3405181 tgcaagctga gataacgcgc cgccccctgg gccaatctcg ctgcctgagt tatcaagaag 3405241 ccttccgccc aatgcctgaa tcatcccggc tcccccgtcg ttcgtggcgc ttccgccgat 3405301 tccgatgatc aatcgctccg ctcccgcatc aagagctgct ccgattaatt ctcccgttcc 3405361 ccttgttgta gtgatgagcg gatttcgctt atctacaggc accagatgca gccctgaagc 3405421 agcagccatt tcaatcacag ctgttctccc atctcccatc atgccaaaga aagctctcac 3405481 cggttccccc agcggccctg tgacaacttg ctctatgatc cttccattgg tcgcatcgac 3405541 cagagattga acggttccct cgccgccatc cgccaccggc aattttctgt aatcagcacc 3405601 cggaaagacc gatttgaaac ctctttctat cgcttcggct gcctccagag ctgataagct 3405661 ttccttaaaa gaatcaggtg caatgatgat tttcatccaa atcgcctctt tcaaaacatg 3405721 attcacttaa cctattgatc tccaatgtac cataattgat ctggaaatac ataccatgca 3405781 atatggtaaa aatttaaata aaaattagaa atgaaagtgt ttgcataaaa gaaatattca 3405841 cgttatcata cttgtataca agtatactcc ttgagtgagg aaggtgagtg tatgctagac 3405901 tccaaagacc tgttgtatcc cgcaaaatgg ctctcaaaag cgtcaaccgg agttcgtgtc 3405961 gcatacgagc tgagaatgcg gatcgtttca ggtctgattg aaagcggtac cattttatca 3406021 gaaaatacaa tcgccgccga gttttcagta agccgttcgc cggttcgcga agcgctaaaa 3406081 atactcgcat ccgaaaaaat catccgctta gaacgaatgg gagcggtcgt aattggttta 3406141 actgagaaga aaatcgcgga aatttatgat gtgcggttac tattagaaac atttgtcttt 3406201 gaacggcttg tcaaaataga cattgagcct ttagttaagg atctcagcaa aattcttgaa 3406261 atgatgaaag tctcaatcaa atatgaggat gctgacgaat tttcatttca agatgtgctg 3406321 ttccatgaaa cgattatccg agcgattgat cattcataca ttcagatgat ctggaacaat 3406381 ctaaaacccg tcatggaaag ctttattctt ttatcgatgc gggtacggtt aaaggaaaag 3406441 tatgaagact tcacaaggat tttagataac cacgagcttt atattcaagc catcaaaaca 3406501 aaggataggg cgctgatgat tcagtctctt caccaaaact ttgatgatgt gcaggataag 3406561 gtagaagacc tatggctctc acaacaaatg ctggcaaaag gagctgaata caacaatgac 3406621 tagttatatg ttaggaatcg atatcggcac gacaagcaca aaagctgtgc tgttcagtga 3406681 aaacggagat gtggtacaga aagaaagcat cggctacccg ctctatacac cggacatctc 3406741 aacagctgaa caaaatccgg aagagatttt tcaggcagtc atccatacaa cagcgagaat 3406801 tacaaaacag catcccgaaa aacggatctc tttcatttcg ttcagcagcg ccatgcacag 3406861 cgtcattgca atcgacgaaa atgacaagcc gctgacgcca tgcattacat gggccgacaa 3406921 cagaagtgaa ggctgggcgc ataagatcaa agaggaattg aacggacatg aggtgtacaa 3406981 acggacggga acaccgattc atccgatggc accgttaagt aaaattgcct ggatcacgaa 3407041 tgaaagaaaa gaaatcgctt ccaaggcaaa aaaatatatc ggcatcaaag aatacatttt 3407101 taaacagctg ttcaatgagt atgtcatcga ttactcattg gcatcagcga caggcatgat 3407161 gaacctgaag ggcttggatt gggacgaaga ggcactgcgc atcgcaggca tcacgccgga 3407221 tcacttatcc aaactcgtgc cgacaaccga gatctttcag cactgcagcc cggaaatagc 3407281 gatccaaatg ggaatcgatc cggaaacgcc ttttgtcatc ggcgccagcg acggcgtgct 3407341 gtccaacctc ggcgtcaacg ccattaaaaa gggtgaaatc gccgtcacca tcggtacaag 3407401 cggtgccatt cggacgatta ttgacaagcc gcaaaccgat gaaaaaggga gaattttttg 3407461 ctatgccttg acggacaagc attgggttat tgggggacct gtgaacaatg ggggcatcgt 3407521 ccttcgctgg atcagagacg agtttgcctc ctccgaaatc gaaacagcga cacggctggg 3407581 cattgatcca tatgacgtgc tgacgaaaat tgcccaacgc gtcagacccg gttctgacgg 3407641 tctgctgttc cacccatatc tcgccggaga acgcgctccg ttgtggaatc cggatgtacg 3407701 cggctcattt ttcggcttga ccatgtcgca taagaaagag catatgatac gcgcggcatt 3407761 ggaaggcgtc atttacaacc tgtacacggt gttcttggcg ttaactgaat gcatggatgg 3407821 cccggtaacc cgcatccaag cgacaggggg ttttgcaagg tcggaggttt ggcgccaaat 3407881 gatgtcggat atcttcgaat cagaggttgt cgttccggaa agctacgaaa gctcatgtct 3407941 cggcgcctgc attttaggcc tgtatgcaac aggaaaaatc gattctttcg acgccgtgtc 3408001 cgatatgatc ggcagcacat acagacatac gccgatcgaa gactcagcca aggaatacag 3408061 aacattaatg ccgattttca tcaatctatc aagattatta gaaaatcaat atacacaaat 3408121 tgcagattat cagaggggct taatcacaca caaatagtac atgacatgaa ggggagggca 3408181 ttaccatgcc gttaatcatc gttgcacttg ggatcttagc attactattt ctgattatgg 3408241 gcttaaaatt aaacacattt atttccctgc tggtcgtatc gttcggcgtg gcactggcac 3408301 tcgggatgcc gttcgataaa gttgtcagct ccatcgaagc aggaataggg gggactcttg 3408361 gccacatcgc gctcatcttc ggactcggtg cgatgctggg caaactgatc gcggattcag 3408421 gaggcgcaca gcgcattgcg atgacgctcg tcaacaaatt cggtgagaaa aatattcaat 3408481 gggccgttgt cattgcctca ttcattattg ggattgcgtt attttttgaa gtaggactgg 3408541 ttctattaat tccgattgtc tttgcgattt caagagaatt gaagatttct attttatttc 3408601 tcggaatccc gatggtcgcg gcactatccg tcacacacgg tttcctgccg ccgcacccgg 3408661 gacctacggc gatcgccggt gagtatggcg caaacattgg agaagtgctg ctgtacggct 3408721 ttatcgttgc tgttccgaca gtgctcattg cagggccgtt atttacaaag ttcgcgaaaa 3408781 aaatcgttcc tgcatcattt gcgaaaaacg gcaatattgc atcactcggc acacaaaaaa 3408841 catttaacct tgaagaaaca cccggctttg gaatcagtgt ctttactgca atgctcccga 3408901 ttatcatcat gtcggtcgcg accattatcg acctgcttca agaaacaatc gggtttgcag 3408961 ataacggagt tttagctttt atcagattga ttggaaacgc atcgactgct atgattattt 3409021 cgttattggt cgcagtctat acaatgggca tcaagcgcaa cattccagtc aaaaccgtga 3409081 tggattcttg ttcaactgcc atttcacaaa tcggcatgat gcttttgatc atcggaggag 3409141 gcggcgcctt caaacaagtg ctgatcaacg gcggtgtcgg cgattacgta gcagacttat 3409201 tcaaaggaac ggcattatcg ccaatcattc tggcatggct catcgcagcg atcctgcgca 3409261 tttctctagg atcggcgact gttgccgcac taagcacaac aggtctggtc attccgttat 3409321 tgggccattc tgatgttaac ctggcgttag tcgtactcgc aacaggagcc ggaagtgtca 3409381 tcgcttcaca cgtcaatgac gccggcttct ggatgttcaa ggaatacttc ggattaagca 3409441 tgaaagaaac attcgccaca tggacattgc tggaaaccat tatttccgtt gctggactgg 3409501 gattcatttt attgttaagt ttagttgtat gaaattaaga aggagctgta acacatgttc 3409561 aattcgattg gtgtcatagg cttaggcgta atgggaagca acatcgcctt aaacatggca 3409621 aataaaggcg aaaacgtcgc tgtctataat tacaccagag atttaacgga ccagcttatc 3409681 caaaagctgg atggacaatc tctcagcccg tattacgagc ttgaggactt tgttcaatcg 3409741 ttagaaaaac caagaaaaat ctttttgatg gtcacagcgg gaaaacccgt agattccgtc 3409801 atccaatcat taaagccttt gcttgaagaa ggcgacgtca tcatggacgg aggaaactcc 3409861 cactatgaag acacagaaag aagatatgac gagctgaagg aaaaagggat cggctacctg 3409921 ggagtcggca tttccggcgg tgaagtcggt gcgttaacag ggccttccat catgccgggc 3409981 ggagatcgcg acgtctatga gaaagccgct cctatcctga cgaaaatcgc agcccaagtc 3410041 ggagatgacc cttgctgtgt ctatatcgga ccaaaagggg cagggcactt tacaaaaatg 3410101 gtgcacaacg gcattgaata tgccgacatg cagctgattg cagaagctta tacgtttcta 3410161 agagaaacgc ttcgtctgcc gctagatgaa attgcatcta tttttgaaac atggaatcaa 3410221 ggtgagctga aaagctattt aatagagatt acagctgaga ttttacgcaa aaaagacgaa 3410281 aaaacaggac agcctctgat cgatgtcatc cttgataaaa ccggccaaaa aggcaccgga 3410341 aaatggacga gcatgcaggc gattgataac ggcatcccgt ccacgatcat cacagagtcc 3410401 ttgttcgccc gctacttgtc atctttaaaa gaagaacgga tggcagctca agatgtatta 3410461 gcaggcccgg aagccgaaga aaaacacttg gataaagaca cttggattga atacgtcaga 3410521 caggctcttt acatggggaa agtatgcgcc tatgcacaag gctttgccca atataagatg 3410581 tcatctgagc tttacggctg gaatctgccg ctcaaagaca tcgccttgat tttccgaggc 3410641 ggctgcatca tccgcgctga tttcctaaac gtgatcagcg aagcattcag tgagcagcca 3410701 aatctggcta acctgctgat cgcgccttat ttcacagata agctccatgc ctatcaaaca 3410761 ggcctgcgaa aagtcgtttg cgagggtatc agcaccggaa tctctttccc atgcttaact 3410821 accgcgctct cttattacga cggctaccgc acagggcgtt ccaatgcgaa cctcttgcag 3410881 gcacagcgcg attactttgg cgctcacacg tacgaacgga ctgatatgga cggcgtcttc 3410941 catacgaatt ggtctgaata acctgtatta aaaacacggt cagtttcaac tgaaccgtgt 3411001 ttttttcttc tatcccaaac aacagaagac ataagttatg ttttaaatat cataaacagt 3411061 gatacaataa tagctagaaa caatccccaa gatcatcatg tgacagcaga ttgctgttcc 3411121 gttctattct gcttttggcc attgtccttt gcccttgacc atggtgtcat aaaatgttca 3411181 aatgccaaaa cggcctggca ttctgattta caaaagtccc tgaaaacctt atctaattga 3411241 gaatcagcct ctcatttatt ataaaagaaa tgcctaaatc ctacctgtca cacctttatt 3411301 aagatgaaaa aaagtaggtt atggcttgac aaaaaatata tattaattaa taattcatat 3411361 ataattagaa ttattattga aagcgattat gctttctaat acatttttag gaggaatata 3411421 cattatgtct ttaatcggta aagaagtact tccattcgaa gcaaaagcat tcaaaaacgg 3411481 tgaattcatc gatgtaacaa acgaagattt gaaaggccaa tggagcgtat tctgcttcta 3411541 cccagcagat ttctctttcg tatgcccaac tgagcttgaa gatcttcaag aacaatatgc 3411601 tgcacttaaa gaattaggtg ttgaagtata ctctgtttct acagatactc acttcgtaca 3411661 caaaggctgg catgacagct ctgaaaaaat cagcaaaatc acttacgcaa tgatcggtga 3411721 cccatctcaa acgatctctc gcaacttcga tgttcttgac gaagaaactg gccttgctga 3411781 ccgcggaaca ttcatcatcg atccagacgg cgttatccaa actgttgaaa tcaatgcagg 3411841 cggtatcggc cgtgacgcaa gcaaccttgt aaacaaagta aaagcagctc aatacgttcg 3411901 tcaaaaccca ggtgaagttt gcccggctaa atgggaagaa ggcggcgaaa ctcttacacc 3411961 tagccttgat ctagtaggta aaatctaagg agtgcattca attggtactt gatgcaaata 3412021 tcaaagcaca attaaatcaa tatatgcagc taattgagaa tgacattgtt ctcaaagtta 3412081 gcgcaggcga agatgacact tctaaggaca tgctggctct cgttgatgag ctggcttcca 3412141 tgtcatcgaa aatttcagtt gaaaaagctg aattaaacag aacgccgagc ttcagtgtca 3412201 atcgtgtcgg agaagacact ggcgtgactt tcgccggtat ccctctgggc cacgaattca 3412261 catcattagt gttggcgttg ctccaagtga gcggcagacc gcctaaggta gaccaaaaag 3412321 tcattgatca ggtgaagaag atcagtggtg aataccactt cgaatcttat atcagcctga 3412381 catgccacaa ctgtcctgat gttgtacaag ctttaaacat gatgagcgtg ctgaacccga 3412441 acattacgca cacgatgatt gacggtgcag catacaaagc agaagttgaa agcaaaaaca 3412501 tcatggcagt gccgaccgtt tacctgaatg gcgaatcctt cggaagcggc cgtatgacgc 3412561 ttgaagaaat tcttgcgaaa atgggcagcg gcacagatgc atctgagttt gctgacaaag 3412621 agccgtttga cgttcttgtg gtcggaggcg gacctgctgg tgcaagtgca gcgatctaca 3412681 ctgcacgtaa aggcatccga actggtgttg tcgctgagcg cttcggcgga caggttctcg 3412741 acaccatgag catcgaaaac ttcatcagcg tcaaagcgac ggaaggaccg aagctagcgg 3412801 caagtcttga agagcatgtg aaggaatatg atattgatgt catgaacctt cagcgtgcga 3412861 aacgccttga gaagaaagat ctgttcgaac ttgaactcga aaacggcgct gtcctgaaaa 3412921 gtaaaacagt gatcctttca acaggtgcac gctggcgcaa tgtcaacgtc cccggtgaac 3412981 aagagttcaa aaacaaaggt gtcgcatact gcccgcactg tgatgggcca ttgtttgaag 3413041 gcaaagacgt tgcggtaatc ggcggcggaa actctggtat cgaagcagcg attgatcttg 3413101 caggtattgt caatcacgtt actgtactag aattcgcgcc ggaactgaaa gcagacgaag 3413161 tcctgcaaaa acgtctctac agcctgccta acgttactgt cgtgaaaaac gcacaaacaa 3413221 aagaaatcac aggtgatcag agtgttaacg gcatcacata tgtagaccgc gaaacaggcg 3413281 aagaaaaaca cgttgaactt caaggtgtat tcgtccaaat cggtctcgtg ccaaacacag 3413341 aatggttaga aggaacggtt gaacgcaacc gcatgggcga aattattgtc gacaaacacg 3413401 gcgcaacaag cgtaccaggc ttatttgctg ccggcgactg cacagacagt gcgtacaacc 3413461 aaattattat ttctatggga tcaggtgcaa ctgccgccct cggcgcgttt gattacctaa 3413521 tccgtaacta atataagaaa tccgctatat tgccagattg gcaggatagc ggatttttct 3413581 ttttctacag aaaaaaaccg aaccaggcac tacggtaaaa gtgctcgatt cgagcgcttc 3413641 ttatagttcc tcaccattcg tttgaatgac atttttatac cactcaaagg agtctttctt 3413701 atatcgtttc atggatccgt ttccttcatt gtcacgatca acatagatca tgccgtagcg 3413761 ttttttcatt tcgccagttg tgaaggagac aatatcaata atgccccacg gcgtgtagcc 3413821 aattaaatca acaccatcgt acgtgaccgc ttttttcaat gcttcaatat gcgattttaa 3413881 atattgaatg cgttccggat catgaacctt gccgtcctcc tccagcgtat ccactgcgcc 3413941 aaagccattt tcaacgatga ataacgggat ttggtatcgg tcataaaaac gatttaacgt 3414001 atatctcaac ccggttggat caatcgccca tccccagtca ctcgaagtga tgtacggatt 3414061 ttcgacacca ttcggcaagc cgccatttac aatatcgcca gtgttatcat ttttcacatc 3414121 gcttttcaca gttgttgaca tgtaatagct gaagcctaag taatcgacgg ttccgtttct 3414181 taaaatctca tcatcgccgt cttcgaatgt gatgttgtag ccttcgcgtt caaattcctt 3414241 caacgcgtag cttggataat aaccgcgaac ctgcacatca gggaagaaat agcgctgcct 3414301 catttcttct tcagccagca tcacatcttc aggattggag gagaaaggat aaatcggcac 3414361 gtgtgatacc atggccccaa tctggaactc tggattgatg tcttttcctt ttgccactgc 3414421 taaggcgctc gccactaatt catggtgcgc cgtttgatac atgacttcct tggcgttttc 3414481 gttttcgcca accacaacac ctgaattcgt ccataggaac agcggattgt tcacatccat 3414541 ttggttgtta atctcgttaa atgtcatcca gtacttcact ttatctttgt aacgggtaaa 3414601 gcaagcctct gcgaagttga cgaagaagtc cacgactttc cggtttctga agccgccata 3414661 ttctcttgcc aggtgcagcg gcatttcaaa gtgagacagg gtaatgaccg gctcgatccc 3414721 atgcttcagc aattcatcaa acacatcatc ataaaactgc aaaccagctt cgttcggttc 3414781 agcctcatcg cctttcggaa aaatccggct ccagccgatg gacgtccgca gacattttaa 3414841 tcccatttcc gcaaacaaag cgatatcttc cttgtatctg tgatagaaat caatggcttc 3414901 atggtttgga taaaattcgt tttcttcaat cgtgtcagtg atttttctcg gcacgccgtg 3414961 cgcacccgct gtcatcacat cgacgacact cggcccttta ccgccttgat tccatccgcc 3415021 ttcaaattgg tgggcagcta aagcaccgcc ccataaaaaa tcctttggca tgtttcccat 3415081 gtttaattcc tcctcagctt acgactgtaa atattttttg atgtaatgca ctttcctcaa 3415141 tgtcttcaat gaaagcttta tcaaactcaa caagcacttc gccttttttg acggtatcgc 3415201 cttcttttac cttcaaggaa aaaggcgtgc cgtcaaatgt caccgtatcc agcccgatgt 3415261 gcgcaagcaa ttcgacgccg gacgctgaac gcaggccaat cgcatgcttt gtaggcgtaa 3415321 ccatgacaac cgtaatgacg ccgggatggt agcatcgatt tcacgatatc cttcgcttta 3415381 ggggtagacc gcttcagcac caatcgaagt ctggtagcgc agcgagaagc cccaatcaca 3415441 ttctcttccc cgcctacggc ctctaaaatg tcttttgcta gtctcgtata atctctcact 3415501 ttccccgaca tttcacccac cccttcgttt tggttacgct ttcattataa ttgtaacggt 3415561 ataatttatc aattccgaaa caaaatattt acgcactaac tatcattgta agcggtttat 3415621 gctataattt tgacaagtga aactaaacga ataaatgagg aatgcgtatg ttaaaatacc 3415681 agcaaatcgc aacggaaatt gaaacatata tagaagaaca ccagcttcag cagggagaca 3415741 aactgccagt cctagaaacc ctcatggccc agtttgaagt cagcaaaagc accatcacaa 3415801 agtccctcga gctattagag caaaaaggcg cgatctttca ggtcagagga agcggcattt 3415861 tcgtcagaaa acataaacga aaaggctata tcagccttct gtcgaatcag ggatttaaaa 3415921 aagatctcga ggatttcaac gtcacctcaa aagtcatcga actggacgtg agaaagccaa 3415981 caccggaagc ggcggaaaac ctgaacatcg gaatggacga ggacatctac tatgtcaaaa 3416041 gggtccgcta catcaacggc cagacccttt gctacgaaga atcctattac accaaatcca 3416101 tcgtgacgta tttaaacaac gaaatcgtct cccactccat cttccattac atccgggaag 3416161 gactggggtt gaagattggt ttttctgatt tgtttctgca cgtgggccag cttaatgagg 3416221 aagaagcgga atatttggga ttagaggctg gactgccgaa gctgtatata gaaagtattt 3416281 ttcacctgac aaatgggcag ccgtttgatt actcgaagat ttcgtataat tatgagcagt 3416341 cgcagtttgt ggtacaggct aatagttttt tattataggg ctcttcacta cggtaggtgg 3416401 tcgacatgta caaaattatc attcctgcca tactagccat ctttgcgctc tggatactct 3416461 tacagatttc actagagatg agcatcgtta agaatccaat gaactacttt atcgtattca 3416521 ttatcttttt cctctttgta aagatggtga aagaaaaaca ataatagttt gggcgatgca 3416581 aacagaaaaa catccttccc ttaacaaact cagccagtca catgcattaa tcttgatgtt 3416641 aatgatatat aggtgcacat aaaaagctac ttcattgtga agtagctccc tttattaaag 3416701 gcccattttg atccatctag ttttagaaaa gcgaaggaca atcgcattta tgataataat 3416761 tgaaactaaa tacaaaataa taaataaaac atcattactc ccaagtgtca tgttatcaga 3416821 ttgcagcact ctttctattc gggggtacat agtgttacct gcctcaaaag gagcaatgaa 3416881 accaaacgtt ttattgctta tagctactaa gataacagaa gtcatccaat aaacgatact 3416941 gacacctata ctaattaata tattaggaca taacacgctt atagttccga taattagaat 3417001 atactgcagt ataactgcag aaaataaaaa aagtaataat gcaaaatgcg aaaaatcatg 3417061 gtacatcaac gatatgatta gcaggcctag cgttataaat gcaaaacatt ctaaaaataa 3417121 aacagctatc tttttataaa agaaagtata gatgttctct ccaattaact tgtaaaagag 3417181 aatatttttg tttgaatact ctctattaat aaagaaagct ataacaaatg aaaataacat 3417241 caaaccaaac tgggtcgcaa cagtatagga gctaaagaaa aacatttcag gtgtaacatt 3417301 actgacttta tcgattccaa caagtaaaaa ataacccagc aaaaataaaa atacaaacat 3417361 tgctcctaaa ataatgataa ctttgttgct aatactcttt ttaaactcta atttcatctc 3417421 aagcccccac tgttttatta ctcatttata tacacttcaa ttaatttatc cactgaatga 3417481 tattgttgaa tttcttggtg attaaatata taataatccc cttctatcgc ctttaaatca 3417541 gacaaatcat gtgtaatgtt gatgataatc ttctcggggt tctcctgaat atacttgttt 3417601 aagaagccat gaatctctat aaccgttttt ttgtctaatg aattcgttat ttcatctaaa 3417661 acaataatat ttttatcctc taataagaaa ctgagcaatt ttaatttttg cttttgtcca 3417721 tcactcaaat ttttgatcag aacttttcca tcaatattat ccagattaag taaatatgcg 3417781 attttatcta tcatttttgc atcaaatttt ttactcaaaa agtgtaataa aaagtcctta 3417841 gaaacatcat taggtatatt cgacgagctg gatattaaag aaacattttg acgaatatct 3417901 ctgccgattc ttttgctatt attcaacaaa aagtctttag caagctgtga tttaccgact 3417961 ccattttttc cgacaacgtg attaattttc ccgctcgaaa aatgcaagtc ggtgtcctga 3418021 agtaacgttt tgcctttcac ttttaaagtg taattcgcta tattcatata catactccta 3418081 ggaaatattt gcataataat aaaatgttct gccttgtgat ttgttactaa tgtctaagct 3418141 tttgaggtac ctctttcgtt tccgatccgg aagcgaaaga aatgttttta gatggctaat 3418201 ttggagatct tttactctag tttacaatat ataatatcca atgtacaact gaattcactg 3418261 caaggccaat ccctataatt tgaatcgtaa gaactaacca atgatttgtc ttaaaacggc 3418321 tatattcatc taagctcaga aaagctaaaa gaattttgta accatcagaa ttcaatattg 3418381 ggattaagtt ccacaataaa gtagacgaga aaagcataaa tgccatagtt aatgcttcac 3418441 tggaaaatgt aaattgattt attaattcta atgtatttat taaaagataa ttgataaaca 3418501 agccaaataa atgaacgatt atcttttcat ttcttgatag catgtaggtt tcattcaatt 3418561 ggacataaaa agcaggaaat acataaaaat tcagtttgaa tcccacttta tcaaagtttt 3418621 tcccgaaaaa ttttaaggaa taaatatgtc ccagttcatg aagcactata ttcattataa 3418681 aataaataac tataattatc cacattttcc agccgtaaaa tactgaggac aatccatttt 3418741 gcaattttat taaatgaata taatttaata tgaacatgag agccgtaaag gataagaaca 3418801 gataaaaaaa ctttggtgat actttctctt tatacatttt aaaacgtaat aattgtttat 3418861 ctgacagaga atttaaacta tttttatagt attctccgct ttttttgtct tttataaata 3418921 cgttgttttg cacaagcact tcatattttt catcttcata ctttaaaatt ttcattatag 3418981 tatttttcca tataaggata gaagtagttt attttttctg cagagttgaa taaggaacca 3419041 caaactccac aaatagagga aaattcataa ggaatgtcaa attcctctat tttgttattt 3419101 tcttttaaaa tattcaaaaa ccatttgaat ccttcttttc taagaataaa taatagcaaa 3419161 ttggaattta acttttccac ggttctttcg aaactttggt tatattcttc ccttagggtt 3419221 attttcgttt caaaaatagc aggggaacaa catggataaa tttctccatc atgatgatat 3419281 acaatgtcat atccgggaca atgtaaggaa tcttcatctt caagactgta aaatttatgt 3419341 atgttttctt gcttaattct agttttagca gcgccaactg atatcattgg aaattttgtt 3419401 atctttacac ctaagattga atcccccaat tcctctaaaa tgtggttgga cattttgtct 3419461 ttggtaactg ccatattaag agaaatatcg atatcagggt atttcctgct atgttctaat 3419521 atgtttttaa tactggaaga cttgacaaat ggagcatggt actcatcata acttatagtc 3419581 agtgctatca catttaaaga attcatatca tgaaagtact cctggacctt tttcttgctc 3419641 aaaccccaaa atccattaga gatcaacgtt atttgttttt catatggttt aatgatttcc 3419701 attagttctt ttaaaaattt ataatctaaa aaaacttccc cacctgtaaa agaaatcact 3419761 tgaatggttt tgttttttgc aaattcagtt actaactctc ttatgtattc tttttccatc 3419821 ctggttgttg aagttggtga actagaaaaa caacaatggt cacaggatgc attacacctt 3419881 gaatctaaat tgattgatac tgttttatta tacatgaaat atcccccaac aaatggtaaa 3419941 ggagagttag actctccttt gtacccctct aattaatgac cacttccaag aatccagcga 3420001 ttttcttttg attttacaaa ataccaaaga tcattcactt ttgctaactt ttgtgattca 3420061 tctaatagac ccttaaattc taagtttttc acagtctcat tgttagtgat ttcctttttc 3420121 atattatccc tcctcctttt ctaatataaa ccaattattc tatatcattc aatacatgtc 3420181 aatatattgt acctaaaaaa tctgaaaaat gtcactattc ttggtatata aagcctatag 3420241 tcctctagcc cctctaagct ataccgaatg aaaggccata gtttgattta aagcttcgta 3420301 atgaaaagta aaacatcaat attgactaca ctagttaagg gatatacaga ttttaagtgg 3420361 aagaaatgag gcaaacaatc ttaccctaaa ccaacctgta ctgaaaagct gttttaagct 3420421 cttgcttacc ccatttggca cctctttctc tcgttttaat tgtctctaaa agcagttatg 3420481 cggtactatc atataaaggt ccaatgttta aaaataatgt catactttta aattcacctt 3420541 atcatgcaca tgctcataaa gaggggttta ttctaaaaag gggatggacg gttttggaaa 3420601 gcaagtacct agatctactc gcacaaaaat acgattgtga agaaaaagtg gtaacagaaa 3420661 tcatcaattt gaaagcgata ttgaacctgc caaaaggcac cgagcatttt gtcagtgatc 3420721 tgcacggaga gtatcaggca ttccagcacg tgttgcgcaa tggttcagga cgagtcaaag 3420781 agaagatacg cgacatcttc agcggtgtca tttacgatag agaaattgat gaattagcag 3420841 cattggtcta ttatccggaa gacaaactga aattaatcaa acatgacttt gatgcgaaag 3420901 aagcgttaaa cgagtggtat aaagaaacga ttcatcgaat gattaagctc gtttcatatt 3420961 gctcctctaa gtatacccgc tccaaattac gcaaagcact gcctgcccaa tttgcttata 3421021 ttacggagga gctgttatac aaaacagaac aagctggcaa caaggagcaa tattactccg 3421081 aaatcattga tcagatcatt gaacttggcc aagccgataa gctgatcacc ggccttgctt 3421141 acagcgttca gcgattggtg gtcgaccatc tgcatgtggt cggcgatatt tatgaccgcg 3421201 gcccgcagcc ggatagaatt atggaagaac tgatcaacta tcattctgtc gatattcagt 3421261 ggggaaatca cgatgtcctt tggatcggcg cctattccgg ttccaaagtg tgcctggcca 3421321 atattatccg catctgtgcc cgctacgaca acctggatat tattgaggac gtgtacggca 3421381 tcaacctgag accgctgctg aacctggccg aaaaatatta tgatgataat ccagcgttcc 3421441 gtccaaaagc agacgaaaac aggccagagg atgagattaa gcaaatcaca aaaatccatc 3421501 aagcgattgc catgatccaa ttcaagcttg agagcccgat tatcaagaga cggccgaact 3421561 ttaatatgga agagcggctg ttattagaga aaatagacta tgacaaaaat gaaatcacgc 3421621 tgaacggaaa aacatatcaa ctggaaaaca cctgctttgc gacgattaat ccggagcagc 3421681 cagatcagct attagaagaa gaagcagaag tcatagacaa gctgctattc tctgtccagc 3421741 attccgaaaa gctgggccgc catatgaatt ttatgatgaa aaaaggcagc ctttatttaa 3421801 aatataacgg caacctgttg attcacggct gtattccagt tgatgaaaac ggcaatatgg 3421861 aaacgatgat gattgaggat aaaccgtatg cgggccgtga gctgctcgat gtatttgaac 3421921 gattcttgcg ggaagccttt gcccacccgg aagaaaccga tgacctggcg acagatatgg 3421981 cttggtattt atggacaggc gaatactcct ccctcttcgg aaaacgcgcc atgacgacat 3422041 ttgagcgcta tttcatcaaa gagaaggaaa cgcataaaga gaagaaaaac ccgtattatt 3422101 atttacgaga agacgaggca acctgccgaa acatcctggc agaattcggc ctcaatccag 3422161 atcacggcca tatcatcaac ggccatacac ctgtaaaaga aatcgaagga gaagacccaa 3422221 tcaaagcaaa cggaaaaatg atcgtcatcg acggcggctt ctccaaagcc taccaatcca 3422281 caacaggcat cgccggctac acgctgctat acaactccta cggcatgcag ctcgtcgccc 3422341 ataaacactt caattccaag gcagaagtcc taagcaccgg aaccgacgtc ttaacggtca 3422401 aacgattagt ggacaaagag cttgagcgga agaaagtgaa ggaaacgaat gtgggtgagg 3422461 aattgttgca ggaagttgcg attttagaga gtttgcggga gtatcggtat atgaagtgag 3422521 gggtgtgggg ttcagggatg gtgatatgcg ctgagaaaat gattggataa atgaaaaacc 3422581 cccgcgggat gcgggggttc aatttaacga aagaatccta aaacggtttg tagttttagg 3422641 attctttcat cttttcagcg tgattgaaaa cccttgaagt ctaggaagaa cgagcattgg 3422701 agcgcagcga atgtttggaa ttcgtgagca ccgaagcgca ggcctgacaa cgaatgcgag 3422761 ggtttgtcga cacgctgaaa cccccgcggg tgcgggggtt ttcttattac agcagcttct 3422821 tccctaacag ggattctacg agctctactg ctgttttgcc cgttttgttt ttgtgatcaa 3422881 ggatcgggtt aacctcaacg aattcggctg aggtaatgat gcctgcgtca tacagcattt 3422941 ccatagccaa atggctctcc cggtagctga tgccgccgac gacaggggtt ccgacacccg 3423001 gtgcgtcgtt cggatcaagt ccgtccagat caaggctcag atggacgcca tcacatgctg 3423061 ataaataatc aagggtttct tcaatgacct ttgtcatgcc aagacgatcg atttcgtgca 3423121 ttgtgtacac cttcatgccg ctttccttaa tgtacttgcg ctccccttca tcaagtgacc 3423181 gggcgccaat gatgacgacg ttttccggtt tgattttagg cgcgtagcct tcaaggttaa 3423241 ccagtgactc gtggccaatg cctaggctga ccgcgagcgg catgccgtga atattgcccg 3423301 atggtgaagt ttcaagtgta ttcaaatcgc cgtgcgcgtc ataccagatg acgccgagat 3423361 tatcgtaatg cttcgctgtg cctgcaagcg tgccgatcgc aatactgtgg tcaccgccca 3423421 ggacaagcgg gaattttttc tcttcaatga ctttgttgac cttttgcgcg agtttttcat 3423481 ttcccgccaa aacggaattc aggtttttca gttcctcgtc atttttgatt ttttcgcgat 3423541 tgatcggaat gtcaccgaga tcttcaaccg tataccccat gtctgacagc ctctcgatca 3423601 gatgagcgta ccggatggca ctcgggccca tatccactcc gcgtcgtgct tgtcctaaat 3423661 ccattggcat tccaataacc gaaatcgttt tatccatctg tgattccacc tcaacattta 3423721 agataatgtc ctatgcgggt tataacaaag atgacttgcg gacaacgttt ttaaagctct 3423781 agctgacgat ttgcctgctg gcgtttttta atgacgacat gataaatgat gtagcaaatg 3423841 atcataaacg gtacgccgca atacagcgcg atacgctgct ccggatcaaa tgcaagactg 3423901 atgagcacga ccgtatttaa cgttaggccg atcagcggaa gcaccgggta cagcggtgtt 3423961 ttaaatttca aatcttctat cttcccgccc tcacggatat atttgcgtct gaacatgatt 3424021 tgggaaagcg agatcgtaat ccagccgacc tgcgcgctca tgcccgccaa agataacagt 3424081 accatatata cggtttcagc ctgcgcaaac tttgtcagaa gtgataggca ggccacagcc 3424141 atcgttacga ttaacgagta catcggtaca ccgcgctgat ttgttttgcc aagcgctttg 3424201 aaggcttgtc cttcattcgc catcgcgtac agaatacgtg ttgatgcgta taaacctgag 3424261 ttcgcaacag ataacagtgc gattaaaata acaaagttca tgatatcagc tgcatatggg 3424321 attccgattt gctcaaatac ggcaacaaat ggactttcca cgacacccgc ctgtttccac 3424381 ggaatcatgc cggcaatgac aatgattgaa agcacaaaga acacaagcgt tctccatact 3424441 gtctgtttga tggaccgcgg aatcgttttt tcagggtctt cactttctcc ggctgcaacc 3424501 ccgatcagct cagtcccctg aaacgcaaag ttcacagtaa tcatcgtaat cagcattgcc 3424561 tttatgccgt tcggaaataa cccgtcttca taaaaatgtg tcaaaaacgg cgcctgctct 3424621 ccgcccttca gatcaatcag gccaaacatg gcagctccgc cgagaataat aaataaaagg 3424681 ataatcaaaa ttttaatgcc tgagaaccag aattcagatt ccgcaaaggc ttttgtggtg 3424741 atcgcattta aaataaacat cagtgccgca aagaccagac accagatcca cacgtctata 3424801 tgcggaaacc agcgttgcat cagctgcccc gctgataaaa attcaatggc gcatgtaacc 3424861 gcccagccga gccagtacag ccagccgaac gcaaacccga aggccgggct gataaatttc 3424921 gtggcatagg tctggaagga ccccgacaca ggaaaggcga ctgccagctc tcctaagcag 3424981 agcatggtca aaaacatgat aaagccgccc actaaatagg acagaaccgc gccgagcggt 3425041 cccgcttggt taatggtaaa cccggttcca aggaagaaac cggttccgat cactccgccc 3425101 aatgaaatca tgaacaaatg gcgtgatttc attgtccgct ggagctgatt tccgttatct 3425161 tggtttgtat tcacattctg caccccttca gcaacttgta ttggatctaa gctggaacat 3425221 ctgcatggtg ctatcccagt ttgctgtcca aagagtctct atctatttaa tataaaattc 3425281 acttcttctc ataaagatac attatactaa aatactgtag ctgagcaaat agggagtgct 3425341 gatttttctg ttgtaaattt atacaaacga agtgaatatc ccgccatggt gcggatttat 3425401 gcgtttcgca gcacgtgctt aattttctct atcgcccaat ccaagtcctc tttggaaatg 3425461 attaatggcg gtgcaaaacg aatgactgta tcatgcgttt ccttgcataa aagtccctct 3425521 tccttcaaac gctcacaata cggacgtgcc gcttcagtca attccacacc gataaacagc 3425581 cctctgccgc ggacttcttt aatgacaggg ctgtcaatac tctcaagctc gcttttaaag 3425641 tattcaccaa gttcaagaga acgatccgcc agcttttcat cctccagcac ttctaatgaa 3425701 gcgatagaca ctgcacatgc aagcgggttt ccaccaaatg ttgagccgtg tgagccaggg 3425761 ttaaacacgc ctaggatctc gcggtccgcc gcaatgcaag agatcgggaa cacaccgccg 3425821 ccaagcgctt tgcccaagat atacatatcc ggaacaatgc cgtcccagtc acaggcaaac 3425881 gtcttgcctg tacgtccgag acccgtctga atttcatccg caataaacaa gacattctct 3425941 tccttacaaa tcgccgccgc ttcctgtaaa aatccttcag gcggaatcac aatgcccgct 3426001 tcgccttgaa tcggttcaaa caagaatgcc gctgtattcg gcgtaatggc ctgtcgaagc 3426061 gcttccacat cgccgtaagg aatgagtttg attcctggaa gcatcgggcc gaatcctcgt 3426121 ttatattcct cttcagaaga aagagatacc gccagcatcg tgcggccgtg gaagttcccg 3426181 acacatgcga taatttccgc ttgattgtca gctacgccct tcacttcata cgcccagcgt 3426241 ctcgccgctt tcaccgcgga ttcaaccgct tcggctcctg tattcatcgg cagaatcatc 3426301 tctttgcctg tcagtttagc tgttttttcg taaaacggcc caagctgatc gttatgaaac 3426361 gcgcgtgacg tgagggtgat tttatcagcc tgatccttta atgcctgaat gattttcggg 3426421 tgtctgtgcc cctggtttac cgcagagtaa gcactcagca tatccatata ttcattgcct 3426481 tccgggtcct ttacccaagc acccagcgct tcagaaataa caatcgggag cgggtgataa 3426541 ttgttggctc cgtaatgaga cgtctgatca ataatttctt tggatttaga taaagctgtc 3426601 atatttgaat tcccccttgt tttctgtttc aacatgttat cctgctttcc ctttatataa 3426661 atgcaagttc tgtgccaaat caagaattcg tgtgttttct acaattttcg aggacaaggt 3426721 gcaaaaacat tctgatattt cgagcgaaaa tttcagcaag tgcaaaattc ttttgcatat 3426781 cctctccgtt tttttataaa atagaagcaa tattaagaaa ataattgagg gaggttcata 3426841 cagtggtcaa agacagcgaa ttcctcacat tggtttttca gagtatttta gatgaaatcg 3426901 atgttggcct gcacgtggta gacgagcatg gaaacacaat cgtttataac aataaaatga 3426961 tgcagattga agatatggag aagcatgacg tcttgaataa aaacctgatg gatgtgttta 3427021 tgttttcaaa gcagcaggac agcacactgg tacaggctct tcaggaaggc aagacgatta 3427081 aaaacgtcaa acagagctat ttcaataata aaggccagga aattacgacg atcaatcata 3427141 catatcccat cgtccaagac ggcaaaatca ggggcgccgt tgaaattgcc aaggatgtga 3427201 caaagctgga acggctgatc agggagaata tgaacaaaaa aggcagcaca acctatacgt 3427261 ttgacagtat tctcggcacc agtccggcca ttcaagacgt catcgaaaac gccaagcggg 3427321 caacccgtac gtcatcatct gtccttctag caggcgaaac cggcacggga aaagaactgt 3427381 tcgcgcaaag tatccataat ggaagcgatc gttctggcgg cccgtttatt tcgcaaaact 3427441 gcgcggcact gccagacagc cttgtggaaa gcattttgtt tgggacgaaa aaaggcgcgt 3427501 ttaccggcgc tgtcgaccag cccggcctgt ttgaacaagc ccacggcggc acactgctgt 3427561 tagatgaaat caactcgctg aatctcagcc ttcaggcgaa gctgctgcgc gcccttcaag 3427621 aacggaaaat caggcgcatc ggttcaacaa aggatacacc gattgacgta cgtattattg 3427681 ccacgatgaa tgaagaccca attgatgcaa ttgcaggcga acgaatgcgg aaggacttgt 3427741 attacaggct gagtgtcgtc acactgatca tcccgccgct tcgggaacga aaagaagaca 3427801 ttttgcttct cgcgtcggag ttcatccaga aaaacaacca tctgttccaa atgaatgttg 3427861 aacacatcag cgatgacgtg aagcaatttt tcctttctta tgactggccg ggaaatattc 3427921 gcgagcttga gcatatgatc gaaggcgcaa tgaatttcat gacggacgag caaacgatta 3427981 cggcttccca tctgccctat caataccgca tgaaaatcaa gccggctgac atcccagagc 3428041 cggaaacacc aagacaccag ccagccgcgg acttaaaaga aaaaatggaa agcttcgaaa 3428101 aatatgtgat agagaacgtg ttaagaaaac acggccataa catctcgaaa gctgctcagg 3428161 agcttggcat cagcagacaa agcctccaat atcggctgaa gaaattttct cactcgtcta 3428221 acgaataatc cggagcagga agcctgatca gaaaaacagt gcctctgccg atttcacttt 3428281 tcacttcaat cgtcccattg tgattgtcga taatcgattt cgttatggca aggcctaatc 3428341 ccgaacctcc atatttccgg gagcgggatg ggtctgcctt gtaaaaccgg tcaaacacta 3428401 aaaaacgtca cttcttatgc attgaagaaa gaaaatggca cctatgtgta tcacagccag 3428461 caaccacacg gtacaaacca ttaaagtcca tgcaaataac ggaagtattt gcagctaact 3428521 gccatttgct gtttcacgtg taacatccat cttgtatttt tcttcatatt cgatatatcc 3428581 tttttcaact gaacgggcgt gacccctgtt cagttttttt tgcatatcaa aacagcctgg 3428641 caacgatgcc agactgcttt tattaactgc ctaattggtc tgcggaggac agcttgatat 3428701 caacagattt ttcttttccg ccgcgataaa acttcacctt cacccggtca ccgacttttt 3428761 tctgataaag ccgttttcgc aggtcaacaa tatcatttac tttgtatccg tcaaattccg 3428821 tgatgacatc cagttccttc agccccgctt ttccggcagg tgaaaaggcg tctacaccca 3428881 tcacaaccgc tccattggtg acgttcttag gaagctttaa tgtttcatcc caatgatagc 3428941 ttgcgatgtc acttagcgat ttcatctcaa tgccaaggaa cgggcgtttg acctttccgt 3429001 atctctctaa atcctctatc acagggatca cgagcttaga cggaatggac aggccaatcc 3429061 cttcaaccgc tgactcggca attttcattg aattgatgcc aatgaccttc ccatccatat 3429121 ttaacaaagc gccgccgctg ttcccagggt taatggccgc atctgtttgc aggacttcag 3429181 cgttccagtc aggctgtcca tcaccgtttg aatctactgg gatcgccctc tccgtacccg 3429241 agatgacgcc ttgtgtgaca gagcctgcaa actcaaggcc taacgggttc ccgatcgcaa 3429301 taaccggctc cccagacttc actttatctg aatttccgaa atcagcgact gctttaatct 3429361 tatcgctttt cacccgtaaa acggcaaggt ccatcagctg gtcgctgccg acaagatcag 3429421 ctgatacacg tgagccgtct ttcaagctga tttcaatttg ggaagcgcct tcgatgacat 3429481 gatggttggt cacgacataa gcggaatggt catttttctt atagatgacg ccagagccgc 3429541 tcccagcctc gccgctctct ccccaaatat ctgatttttg gatgttcaca acaccgacaa 3429601 cggcgggcga catattgctg acaatcttgg tgacggcatt gttgacactg acattcaccg 3429661 tcctgattga ttcccggcca ttgttgtttt gctgctgatc taaggcgcct gtatccagcc 3429721 cttcatttga aaggtacggc atgataaacg ccattaatac ggcaccgaca atcacgccaa 3429781 tcagactcga aagaaaatat ccttttttgc ttctctttgg ctgttcagga gtagtatgtt 3429841 cttcctcacg ttcgtaatcc accatattcc atcctttcca agaacgttaa tatggttata 3429901 ttgtgggtta gaaactccta gaatagtcat gatttacata gaaaaattat acagcgcaaa 3429961 gcggagtggc cttcttcgga tcggtgtcgt ataagtcaaa tgtctcaccc gtcacaaatc 3430021 ctttagaagc caatgtctgc tgcacagaca ttcttgccag ctccttcatg ttgttgtcct 3430081 ggctcaaatg cgccaggtaa atacgagacg tctcatcgcc aatgacatcc gtcatcgcca 3430141 aggcagcatc ttcatttgac acgtgcccga cgtcacttaa aatccgccgc ttaatgctcc 3430201 atgggtatct tcccatttgc agcataccga catcgtgatt gctttcaaac acaaatacat 3430261 tcgctgaacg gataatgcct ttcatccggt cgctgacata tcccgtatct gtcattaacg 3430321 cgagctttcg gccgctataa tggaatacat aaaacatcgg ttccgccgca tcgtgggaaa 3430381 cgccaaacga ttcaacatca agtccgccga acgacttcac cgtctccatt ggaaatacaa 3430441 acttttgatc ggtgtcaatt ttgccgattt gattctccat cgctttccaa gtcttctcat 3430501 tcgcatagat cggaagcttg tactttctgg cgacgacacc aaggccctta atatggtcac 3430561 tatgctcatg cgtcacaaaa atgccgtcta catcatccag cttacgcccg atctgcgcca 3430621 tcagcccatc catggctttt ccgctcaaac cggcgtccac taaaaatgcg tgatcctctg 3430681 tttcgaggta aaacgcattt cccgtactcc cgctcgcaag tacgctaaat tgcaagctca 3430741 tgtttgtctc actccattat tttcattgat ctgtatctaa aatcgtactc tccaaagcat 3430801 tcacagtaaa atactcttgt actgtctttt tctcaccgtt cacttttttc tcgtactcga 3430861 ccgtaattct ccataccggc gccagcacct gcgtacttgt cagcggatat tgtgctacat 3430921 agccgaattt acagctcttc acagtgctgt attcttttaa ttgattttga tagtacaata 3430981 gctcaaccgc atccatttca gtaattaagc tttctttctg gatttgcttg aaggtctcaa 3431041 gcgtagtctg gtcgtatgac acaacctcgt ttttaccgtt taagtgcagc accacttgcc 3431101 cgatcatatt agagggattg tcggtctttt ggtaaatata atgaccttcg tacgtttgga 3431161 agaaaataat ttctttcttc gatttatcaa ccttccaaag cttatatttt tcgccatctt 3431221 gaattttcga agaaacaagt gcctgagcat cgtcctcgat atccttcttt gatagtgcga 3431281 ttggatttgc aaacttcatt ttcaggctcg ttactttatg atcatcacta ggcatgtcca 3431341 tcaaaggctt ttgatccttc agcgcctcaa tttcctcctt ggagaaagac ttttgatttg 3431401 ccgtgatccg atagccttct gttgcttcct tattcaagcc ttcatacgtg atatgatcgg 3431461 ccttcatgtc atgctcgaca tcatttttaa tgacttcata ttctttgccg gtagcctgcc 3431521 atttttgaaa aaactgatag cctaagaaaa tatctaaaat gaggaaggca acgatgaaga 3431581 ttgattttgt cttattccac tccactgtta gccccctcct tcctcaataa atcctttgta 3431641 atcggcacaa tttttccatt tactttcatc gcccaaaccg gttccagttc aacgagagga 3431701 tcatcgttgg ttgatgttga taccaattga taagcaagga agatctgatc aattttgtcc 3431761 gtatcataag cggtttgttt cgaaagcagc atcttcactt cgctgccgcc catgagctct 3431821 gtttcacttg ttttaatcgg attcgttccg agactgtaat tcggccgctt atagctgaga 3431881 atatcatcat tcgcccattg caccgtaatc gccgatgtcg ccccgaaagg tttggcggtg 3431941 ctgttaatga ccgggatctg atccataaaa atatagaagc tcaactgctg gctgtcattg 3432001 atattgaaaa attgatagtg atccgtccag cttccggtat cctcaaggta tttttggctc 3432061 tttttgatta attcacctgt ttgataggat gtgctctgca ccaaattgcg ctgctgaaat 3432121 tgcacctgtc tctggcttag attcacatct aaccggctga tcccatctgt cagcacattt 3432181 ctgttggtgt aattcgaatc ttctcttaca atgctcggat cactaaacaa agcctgctta 3432241 aaggtatttg ttttaatcga ttctgtgaca aattcttttt tgtccatcgt aagcggtttg 3432301 ttcggcagca agaactcttt ctttgagcca atggagaaca aactgaacgc cggcatattt 3432361 gattgcctgt ttttcaagtc gttcataatg ttccggtagt ttgctgattc aaccgtcact 3432421 tcaagaatga gctgcttgct gtatgacacc aaatagattt tcttgttcgc ttttgtttca 3432481 ttgaacggga tcagaatatg gtcaaacgaa ctgtattcaa acgactgatt agaccattta 3432541 aacagcgttt ggaaaatatc aatcgggatc gtatcgctga attgcaagtc aagcttggct 3432601 tcagaaccgc ctattccata aaaccagctt ttgaatccag ccttgtcata ctgatccgaa 3432661 atatctttaa ttcctttcac atcccaatgc ggcaagtcag accaaatttc ttcatagagg 3432721 gcattgtcat ccactttgta atgagcgccg tcatcatgga taaacatgtc ccttggcctt 3432781 accgtttcag acagcttttg ggtggttttt tcgattttat gtttcacacg aacagtagac 3432841 tctgttgagg atgagccttc agaaaagttt ggctggaacg tccatatccc ccatgtaaaa 3432901 acaagactga tgacgacgag taccgtaagt aatatcgttt ttatattttc acgcttcatc 3432961 ccaatcatcc tcttgttcct ctttatatgg aagagtaaat gtaatcgtcg tgccttttcc 3433021 ttctatgctg tccgcccaaa tatctccacc gtgcgcctgt accatttcct tggcaatcgc 3433081 caatcccaga ccggtgccgc caagctttct cgttctcgct ttatccaccc tgtagaagcg 3433141 gtcaaagact ttttcgacat cttttttcgg aatgccgatc ccttcatcct tcacgctgat 3433201 atagagaagt tcttcctctt cattgacatc aatcgagaac gtgacatgtc cgccttccgg 3433261 tgaatatttt aaagcgttag aaataatatt atcgagcacc tgcgttattt tatcctggtc 3433321 aatctcgaca tacagatctc tgtccggcag attgcggata aactccacat gctgctcttt 3433381 tgtcatttca aaacggtcaa taataagtga cataaaccgg acaatctgaa tccattcccg 3433441 gttaaattga taatctttac tgtcaaattt cgacagctga agcagatcat tgacaagccg 3433501 gatcatacgc tctgtttcat tttgcgtcac cattaagaag cgcggagcaa tgtctttatt 3433561 ttcccacgcg ccttcagcta acgcttctaa atagctgcgc attgtcgtaa gcggcgtccg 3433621 cagctcatgt gatacattcg caacgaattc tctgcgttcc tgatccattt tctcttgttc 3433681 ggttacatcg taaatgacag cgattaaacc atcaattttg ccgtgttccc tttgaatcac 3433741 agagaaattc acgcgaagca ccgttaattc atcatcgcgc tcaatttcaa gcagcataga 3433801 atcctgctgt tccactaaat cttcaaaagt ataattctct tgaagcccca gcaaactcgt 3433861 aatcggcatt tctaaggctg tttcacgtga aacgttcaac agttccagcg ccgggctgtt 3433921 taagagaata atcgctccgt ttcggtttgt ggcgataacg ccgtctgtca tataagcaat 3433981 gacagaggct agctttctgc gttctccttc agtcatcgcc tgggcatctt caagctctct 3434041 cgttaagtgg ttaaacgttg tggccagctg cccaatttca tcatgtccat actttttaac 3434101 cttcctcgag aaattccctt tcgcaagctc catcgcctgc tttcgcatat ctgaaagcgg 3434161 gtgggtaatg gttcttgcca gaaaaatacc gagaagagcc gtcaaaacaa gtgccaaacc 3434221 tgtgccggac gccagtatcg tgttgatcgt cttcatttga ttaaagacat cttccatact 3434281 cgcgacaacg tagatcgcgc ccacaacctc ttggttttca gtcatgacgg gcttcgcgga 3434341 aataagaact ctgattttgc ttttcgggtc ataatatttt cttaaatacg actgtttggt 3434401 agaaaagatt cttttgaaaa tcagatcggt cgtttgtttc ccagccactt cctcaccgta 3434461 cggctttgaa gaaccgacca cttcatagct tttatctaca aagctaattt cccgaacctc 3434521 atcacttttc gtgaagtcat tcaaaatacg gctgacgtca tcctttatga cggtactgtc 3434581 gttatcgctc ttatattctt gttcgatata ataagaaagg ttgtcgattc gctgattcag 3434641 cgattgttca taagagctga tcagcgactt ctctacctga ttgacaaaat acacaccaat 3434701 gatttgcatg gcaatgataa tcaaaagcac ataaatcaag gtaatcttaa attggatcga 3434761 ccgaaaaaaa ccaaccttat tcatatgggc attagtcctg ttctgggttt ctcaagtaat 3434821 aacctacacc acggcgtgtg acgatccaat ttggatggct cgggttgtcc tcgatttttt 3434881 cacgaagccg gcggactgtt acgtcaaccg ttctgacatc gccgaagtaa tcatagcccc 3434941 aaacggtttg aagcaaatgt tcacgggtca tcacttgtcc gatatgtttt gctaaataat 3435001 gaagcaattc gaactcacga tgagtcaatt cgattgtttc gtctcgtttt gatacaacgt 3435061 acgcgtcagg gaagatgacg agagagccga tatgaatctc gttagaggaa ggctcttcct 3435121 ccgcaggcgc tgttgtcagc tggcggcgca ggttcgcttt tacacgcgcc aagagctcgc 3435181 gtgtgctgaa tggttttgtg acatagtcat cagcaccgat ttcaagcccg ataaccttgt 3435241 caatttctga atccttagcc gtcagcataa tgattggcat atcgtatttc tttctgactt 3435301 cgcggcatac ttcaacgccg tctttatttg ggagcataat atctaaaaga attaaatcag 3435361 gctgaagctc ttctaccatt tcaacggctt cgtttccgtc gtgggcacag tgcacttcat 3435421 agccttcttt tcttaagtta aattccaata tatctgcaat cggtttttca tcatctacta 3435481 caaggatctt tttatccatc attttgattt tcctcctgcc gaatgacttc atttcatcta 3435541 tataacattc gtttcatcac ttatggccca tgtaaagaat gggtccttgt ctattataac 3435601 ggtttaaggt caaaagataa aaaaaataaa ggtttagaaa aaaaacacat gtttcacctt 3435661 tatcgccagt tgtttatcta ttgtcatgct ggtcaacttt ttttaaaaaa gataacttta 3435721 ttgaaacctc ccctcaccgg agtgcgtctt tatcaatgac gtcttcttct ttgaaccggc 3435781 cgcagggccg gttctccctt tttcttctat tataacactc ctcatgtttg cctttttcct 3435841 aaaagaaaaa acgcacctac gattgcagat gcgtttggta agtggctcgg gacggaatcg 3435901 aaccgccgac acacggattt tcagtccgtt gctctaccaa ctgagctacc gagccaaatg 3435961 ttttattttt ctctactaag taaagtaaaa tggcggtccg gacgggactc gaacccgcga 3436021 cctcctgcgt gacaggcagg cattctaacc aactgaacta ccggacctta cagtaattgc 3436081 ccggagagct gtcgtgtcag ctctcacaga caaataagga atttagcaat aacgctaaag 3436141 taaatcaatg acccgtacgg gattcgaacc cgtgttaccg ccgtgaaagg gcggtgtctt 3436201 aaccgcttga ccaacgggcc ttcacgaaat ggtgagccat gaaggactcg aaccttcgac 3436261 cctctgatta aaagtcagat gctctaccaa ctgagctaat ggctcttaaa gatgtcggaa 3436321 tttctataga gcaaacgact taaatctagt tctcatcttg tactctattg aagcagtttc 3436381 cgtaacaacg agatttataa tatcacgaac aaatagaagt ggcaataact tttttggttt 3436441 tttttcatat ttttttctca gaccaactta tatgcggctt tcaaacaaaa aacaagcccc 3436501 ttaaataggg gcttgcagac atattctatt tagttcgcac ggtacacact gcgaaggaca 3436561 tttgtttgtg agcggtctgg accgacagag aaaatagaaa gcggaatgcc tgtcagctga 3436621 gacacacgct caagataatg gcgcgcattt tccggaagct cgctcaagct cttcgcacct 3436681 gtaatatcct cagtccagcc cggcatttct tcatataccg gctcacattc agcaagtgcc 3436741 ttaagacttg ctgggaattc ttcaatgatt tcgcctttgt agcggtacgc cacacagatt 3436801 ttcaacgttt caattcctgc taggacgtca attgagttca gagaaagatc tgtaattccg 3436861 ctcacacggc gggcgtggcg gacaacaacg ctgtcaaacc agccgacacg gcgcgggcgg 3436921 cctgttgttg ttccatattc gcgtccgact tcacggattt gatcgccgat ttcatctttc 3436981 agctcagtcg gaaaaggacc gtcgccgaca cgagtcgtat atgcttttga tacaccgaca 3437041 acgtgcttga ttttggtcgg gccgacacca gaaccgatcg tgacaccgcc ggcaaccggg 3437101 ttagatgacg taacaaacgg gtatgttcct tggtcgatat cgagcataac cccttgtgcg 3437161 ccttcaaata atacacggcg cccttcatca agagcatcgt ttaagacaac agatgtatcg 3437221 caaacatact ttttaatctg ctgtccgtac tcataatatt cgtctaagat atcctcaagt 3437281 ttaaaccctt ctgtctcgta cattttctcg agaagacggt ttttttcttc aagattgcgc 3437341 tcaagctttt ccgcaaacgc gtcacggtct aacagatccg cgatgcgaat tccgatgcgg 3437401 gctgctttat ccatgtaagc agggccgatt ccttttttcg ttgtgccgat cttgttagcc 3437461 cctttacgct cttcttccac ttcatccaat ttcaaatgat acggcagaat gacgtgagct 3437521 ctgttgctga ttctcaggtt atctgtactc acgttgcgct catgaagata cgcaagctct 3437581 gtgactaatg ctttcggatc tacaaccatt ccgtttccga ttacacacgt tttatcctta 3437641 tagaaaattc cagacgggat taagtgaagc ttatatgtga ttccgtcaaa cttgattgta 3437701 tgccctgcgt tatttccgcc ttgataacgg gcgatcactt ctgcattttc tgataggaaa 3437761 tctgtaattt taccttttcc ttcatcgccc cattgcgtac ctactacaac tactgaagac 3437821 atgtccgtgc acctccgtta acctttcaaa acgattctat tcaaacaaat caagtttatc 3437881 agtgaagaaa cagaaagtca attgtaaatc cgaacattaa tttattgtaa atctatattc 3437941 gttcgcttcc attcgtttta taagcgtttt ctcactgctt tgtcataaaa agcttgcgaa 3438001 actttcatcc tttagcataa gaaagaatca cttgcctgat atcccttttg aattcataaa 3438061 aacgatccgc cagccgtccg ggtcctctat cgtcacgccc ccattgctcc agtacgggtt 3438121 ctctgattcg acctcttgat agcccatgtg ctttagcttt gaagtgatcg ctgccagttc 3438181 aactgcattc ggcacataaa aaacaagaag gctgtcggga tggggaacgg gggcagtgct 3438241 tcccccttca tactgggtga attccaaatg ataatcggca tgaggaaggc cgaacatgac 3438301 accgtcatac ccgttatgct gtgaaaattc tcctattcgt ttcaaacaca gtccctcttc 3438361 gtaaaaacga ataatctcat caagctggcc cgtaggacgc gcaattcgga tttgtgctgc 3438421 ttgaaaagac gaaaaacgtt ttcccatatt gttaccatct cctttttgca ccattttatt 3438481 aaaacgcttt caatttttca tccgctgagc gaacgtcatt tcttccatct ttcgaatgaa 3438541 aaaaacccca agagcagctc ttggggctta tgcgccgggc ggaacgcctg cgtcatcaaa 3438601 acgccgttcc aggttgacga atttgttgta ttcttttacg aacgcaagag acacggttcc 3438661 taccgggccg ttacgctgtt tggcgataat aatttcgata atatttttat tctcggtttc 3438721 tttgtcatag tagtcatcac gataaaggaa cgcgacaata tccgcgtcct gctcgatact 3438781 tcctgattcc cggatatcag acatcatcgg acgtttatcc tgacgctgct caacacccct 3438841 ggaaagctga gaaagcgcga taacagggac ttgcagctcc ctcgcaatcg acttcagttc 3438901 acgggaaatt tcagatactt cctgctgacg gttgtccttt gaacgaccgc ttccctgaat 3438961 caattgcagg taatcgatca aaatcatgcc cagcccgctt tcctgcttca agcggcggca 3439021 cttggcacgg atttcactca ctcgaatacc cggtgtatca tcgatgtaaa tcccgctgtt 3439081 cgataggctt cccattgcca tcgtcagctt gccccaatcc tcttcggtca ggttacctgt 3439141 acggagattc tgggcattga tatttccctc ggcacagagc atacgcataa cgagctgctc 3439201 ggcacccatc tcaagactga aaatcgctac gctctcatcg gtcttcgtcg ccacgttttg 3439261 tgcgatgttc agggcaaagg ctgttttccc tactgaagga cgggcagcca caatgatcaa 3439321 gtcgttgcgc tggaaacccg cagtcatccg gtcaagctcc gtaaaccctg ttggaattcc 3439381 cgtgatatca ccttttcgat tgtgaagctg ttcgatatta tcataggtct ggacaaggac 3439441 gtccttaata ttttggaagg cactcgtgtt tttgcgctgt gccacttcca taatcgtttt 3439501 ttccgcttca ctgagtaaat cctcgacctc atcctcacgg gtatacccgt cttgagcaat 3439561 cgttgtcgca gttctgatta atcggcgaag aatcgatttt tcctcaacga ttttcgcgta 3439621 atattctatg ttagccgctg tcggcaccga gtttgcgata tctgtcaaat atgaaatacc 3439681 gcctacttct tccagcaggt ctgtgttcgc aagctctgat gtaactgtca ccagatcaac 3439741 cggttcacct cggtcaccga gcaccagcat cgcattatag attttttggt gggacattct 3439801 atagaaatca tctggaatca atacttctga agccagtgtt aaagcagacg gctgtaaaaa 3439861 aatagcgcct aacacggctt gttcggcttc tatattttgc ggaggaagcc ggtcattcag 3439921 aaggtctgtc atgctaagca ccgtcctctc attaaaaaat ctccaacctc cattctacca 3439981 tttctacaga aaaaaaatag aaaaattgtc tgtttcctgt ttttttcagt tagcagattg 3440041 gatcgtttcg gacagtaaca aggcgggaaa aatgcaataa aacataaggg aggaatgaaa 3440101 gatgataaag aaatatgcga ttacacctaa tgttgatgcg gacggctggt ttattgaggt 3440161 ggagaatgta gcgccgacag ctttgtatac gtctaaagac gccgctattg aaaaggccaa 3440221 acaggtggct aaggaaaaca gtccgtctaa gcttgtaatt tatgaccagt ttaaaaatgt 3440281 ggaagaagaa cactcatttt aatgaatgaa agccttcgct gcagcgaggg ttttttagcg 3440341 gttatcggtt tatttcatcc attggatgcc tatgtgcatc atcaaatctg ccgctttttg 3440401 atacagatcc cactccccga tcgaagcaaa tttccccatc agctcctgaa gctttaacct 3440461 cattgctata tattcttcga aagtgacagc tttttcagtg tctatttggt gttccttcag 3440521 catttgtttt aataaggata acggtgcgtg cataagaacc ctccttacct cttttataac 3440581 ggtcattttc cgattgctct attcctttgt gacatcttct tacatttcac atctgattct 3440641 tgtacaatgg acagaagaga ggagggatct tttgtgagac ctttgcaaat ttctgccgaa 3440701 actgcacaaa agcttgcaga gtccttgaat ctgccgcttg aacagatcat gcatatgcct 3440761 cagcatattc tgcttgccaa aatggctgaa ctgcaaaaag aggacaaatc atagccttca 3440821 ttcacatact tgcttacctg tttcgggata atatcatgta tatgttagaa aagaggagta 3440881 actgctttgc cacatccaca taataaaaaa atccaatcat tttggctgat caccggcatt 3440941 atctttatcg cctttaactt acggcccgcg atcacttcag tcggtccggt catcagctct 3441001 atccgggcag agctgcacat gtccaatggg gcagccggtt ttttgaccgc actgccgctg 3441061 ctttcgtttg cagttctttc tccgcttgca cctaagcttg gacagcgcct cggtaatgag 3441121 cgaactttat ggctaggtct cgtgatactg ctgatcggtg ttctgactcg ttctaccggc 3441181 tatactgccg ctttgttttt cggaacagca cttatcggcg tcgggattgc gattggtaac 3441241 gtacttttgc caagcttaat caaacataaa taccctgaaa agccagggat catgatcagc 3441301 ctgtatacga catcaatgaa tatattcgca gctttagcat cgggtgtcag cgttccttta 3441361 gcgacccaga tgaatggcgg atggaaacaa gcctttctct tatggggcgg gctggcttta 3441421 cttgcattgc taatctggat acctcagctg cgccatcgag atacggcaaa ccagacaatg 3441481 aagctgcaat ccagttccat ttgggcttcc aaaatggcat ggtatgtcac catctttatg 3441541 ggcctgcaat cgtttttatt ttacagcagc atcgcttggt ttcctgaaat tctccgttca 3441601 cacgggattg atacggcaac agccggatgg atggtatcac tcatgcaatt tgcgagtctg 3441661 ccttccactt ttctgacgcc agttttagct gaccgtgtga aacagcagcg cggtatcgtt 3441721 gcggcgctgg cctcagttta tctgatcggc ctttgcggat tattagcggg cggaagccat 3441781 acattgcttg ccatctggat gatcattatc ggtatcggac aaggctccag cattagtctg 3441841 gcccttactt tgattggtct ccgcagtgaa aatgcccaac aggccgctgc gctgtcaggc 3441901 atgtctcagt cattcggcta cctgctggca gcagtcgggc caatctttgt cggctatctc 3441961 tttgaccaga cgcattcttg gacgatgccg attgtgcttc tcattgctgc cctgatcgta 3442021 atgggagcag ccggacaggg agccggacga gatcgataca ttttccagtc agaaaaacaa 3442081 agaaattcag cataaagcgg ggaagatatc tccgcttttt tctttgaata tttatggttt 3442141 attcataagt ttttcatatt tgttttttac aatgagacac cataaagagg tgaaaaacga 3442201 tgaaaaccaa acgattcgac gcagccctta ttcttatttt gctagcagca gcttttttga 3442261 atacgtatca catttggcag gatgatacag caaaccagta ctatttggcg gctgtaaaaa 3442321 gcatgacgca aagcttccat aacttttttt atgcgtcatt tgacccttct ggatttgtga 3442381 cagtagataa gcctcctgtc gtgttatgga ttcaaacgat tttcgcactg attttcggtg 3442441 ttcacacgtg gagtgtcatc attccccagg ctcttgccgg agttggatct gtcttccttc 3442501 tctacagaat ggttaagccg acttttggag ttggagcggc ccgcattgcc gcacttgtca 3442561 tggcactgac ccctatcgca gtagctgtca gccggacaaa caatatcgac agcatgcttg 3442621 tttttacctt attgctcggt tcaacttgtc tgcttagggc agtaaaacaa ggcaagctgg 3442681 tttggctgct gacggcattt gccctgattg ggctcgcctt taatatgaag atgatgcaag 3442741 cgtttatggt attgcctgca tttgtgttat tctacctgat tgcatctcgg gtttctctga 3442801 agaaaaaaat cgggtccctg cttctgtctc ttgtccttct gacaggcctt tcactctcat 3442861 gggcgattgc agtggattca gcctcttcct caagccggcc ttatgtagga agcagccaga 3442921 ctaactcagt gctagaactg gcctttggct acaacggcac agagcgtctg tttgggcaaa 3442981 ctacgggcct tgcaaagggt gatatgaatg ctgctggcgg agggaacatg cagaatcaag 3443041 acaacatgca agcgccaaat ggcaacggtt catctttttc tcagaacggt aatcaatcat 3443101 tcggaaacca ttcacaggcg cctcagccgc ctaacggaca aaccggcgct ctcaatggag 3443161 gcggaggcac acctcccaca ggtggcaacg gacctggaaa tggagggcct ggcggcggag 3443221 gcggaaaaag cgtgaatatg ttcggcaccg gtgatcctgg accgcttcgt ctcttccaat 3443281 cagcactttc cggccaaatc agctggatgc ttccattctc attgatcgga ttactgggcg 3443341 caatcatcag ctggtaccgt gatcgccgcg gacatgctgc taaaatgaaa gaaacgctat 3443401 tctgggcggc ttggcttgtt cccgtggctg gtttcttcag catcgcagga ttcttccacc 3443461 agtattattt gattatgctg gcaccgccga ttgccgccct ttctggtatc ggatggtata 3443521 cgatgcaccg cttatacaaa aataataaag actggtccag ctatcttctg ccggcagccg 3443581 tcttgatcac agccgtgttt caggtgtata ttctgagcgc ttatacaagc caaatcggca 3443641 gtgtatggat gtatgtcctg gggctcttag gactgggcat cacccttgca cttctgatgc 3443701 ttaaacgcag ccatccgttc agtaagctgc tgaccatcat cagcttgtgc gttctgcttc 3443761 tcacaccagt ttactggtca gcaacgccgc ttctatacgg tggcaacagc gtccttcctg 3443821 aatccggccc gcagctcaaa ggctcagcaa acggcgggaa catgttctct tcagaggtcg 3443881 acagcgggct cctgtcctat ctgagaaaac acaataccgg cgaagagtat ttatttgcta 3443941 ctttgacaac cgtaacagct gcgccataca tcatttacga aaatgaatct gttatggcaa 3444001 tgggcgggtt taacggcacg gatcccattc tgactgtgtc ggaactgaaa aaactgatca 3444061 aagaaggcaa agtgaaatac ttccttctgt cagaaaacaa ctcaggcaac agcgaacttg 3444121 tttcctggat taagaaaaac ggaaaagaaa taacatctga cgagtacagc ggttcctcca 3444181 gcagcacaaa cagcgtgcag ggaatgcgaa gaggacctgg cggagaaagc cagcaaactc 3444241 tttatctcgt ggaataaaaa aagaggcttg gatgaatcca agcctctttt ctattaagct 3444301 tcttctttta catgtacctt taacacagcc tgcacttcag gatgcagctt cacaggcacg 3444361 tttgtatatc ctaatgcacg aatgccgtcc ggcagttcaa gcttccgctt atctacttta 3444421 atgttatggt ctttttggag ctgttcagtg atttgcttgc ttgtcactga accaaataaa 3444481 cggccgccct cacctgattt tgcgctaagc tcaacagtca gtttttctaa tgtctctttc 3444541 aagctcttag cctgctcaag ctcagcaatg gcttcttttt tctctttctg cttttgtccg 3444601 tttaacgcgc tgatgtttga cgcgttcgct tcaaccgcga ggcctttttt aattagaaag 3444661 ttatgcgcat aaccgtctgc tacgtttttg acttcgcctt tttttccttt tccttttaca 3444721 tcttgtaaga aaataacctt catctctgta cgcctccctc aaaatactca tctatggcgt 3444781 gcttcagccg ttccagcgct tcagaaactg aaatgccgga caactgagtc gccgcatttg 3444841 ttaaatgccc tccgccttcc agggcctcca tgatgatctg aacatttacc tcgccaagcg 3444901 accgagcact gatacaaacc gtttgttcat cccgtctcgc caccgcaaat gaagcctcaa 3444961 cctcactcat cgatagcagc gaatcggcag cctgcgcaat cagcacttga tcgaagtatt 3445021 cctcttcatt ttcaggaaga gaagcaatcg caatgttatc tttatagagg accgtatgct 3445081 ggatcagctt cgcccgttta atataggaat caacggtttc tttcagaaac ttctgcacca 3445141 gcaccgtgtc ggcgcctttt gcccttaaat aagaagccgc atcgaaagtc cgcgagcccg 3445201 tgcggagaga aaagctcttt gtatccacta ttataccagc taatagggct gttgcttcaa 3445261 tcatattgat ttttaagcgc ttcggctgat attcaagcag ctctgtcacc aattccgctg 3445321 tggaagaagc gtatggttcc atataaacga gcagcggatc tctgataaac tcctcacctc 3445381 ttcggtgatg gtcgatgacc acgatatgtt caattttatt gaccagccgt tcctccatga 3445441 cgagtgacgg cttatgtgta tcaacgatca caagcagtgt gtcatcattg gaaatctcca 3445501 ttgcttcttc aggcgtaata aatcttgacc acagttcttc atattttttg atttccccaa 3445561 tcaaacgctg cacacttgat ccgatttggt ttgggtcaat cacgataaaa ccatctttgt 3445621 tatttgcctg agccaccttt aaaatcccga tcgctgcgcc gatagaatcc atgtcgggga 3445681 atttatgccc catgataatc acattgctgc tttcggtgac gatttccttt aaggcgtgag 3445741 aaatcacgcg ggcccgcacc cttgttcgtt tctccattgg gtttgtttta ccgccgtaaa 3445801 acttcacctt gccgtttggc agcttaatgg ctacctggtc tccgccgcgt cccagtgcta 3445861 agtccaagct ggattgcgcc aaatcgccaa gttctttcag ggaagagact gaagccccga 3445921 caccgacgct taacgtcagc gctacaccgt caaacgaggt tttttcccgc acttcatcaa 3445981 gaatcgaaaa cttcgaattt tcgagttcag ttaagatatg ttcattaagt acagcaataa 3446041 agcgttctga agacgtcctt ttcaagaaga tcccgtactc ctgcgcccaa gcgttcagca 3446101 aagatgtcac ctggctgttc atcgtgcttc tcgtctggtc atccaatcct tgtgtcacat 3446161 catcatagtt atcaaggaaa atatatgcca ggacggttct ttcgttttca tatagctttt 3446221 caatctggat ttgttctgtt acatcaaaga aatataagag acgctcatcc cgtttgatga 3446281 caaccctaaa cttgcggtca ttcaatgtaa ccgtttccga ttccacctct tgtttgataa 3446341 gcggcactac cgattcacaa gtatcgtaaa gtgatctccc cactaaagtg ctttcattaa 3446401 aacaagagga aagaaacgga tttgcccatt ctatataata ttggtcatta aaaagcatga 3446461 ttccaatcgg catttccatc aatgcctctt caccgacttt tttcaacctg taggacaacg 3446521 tagaaatata agcatcaatc tcttgtcgaa taagagaatc agcacgctta ataaaaaaca 3446581 aaataactgc cagcagcagc acttcgacgg ttcctaatat ccagttaaaa taaaagctga 3446641 tgaggattgt aataattgac agagcaatca atgcatagat gggataccga aacagcggtt 3446701 tttcataaaa gcttggcatt tctatcactc cccaccatgt gagtaaaact catgttcact 3446761 tcaccttatt ccttatatga aagcccatat ctaaaacgcc taaaatgcga atggccgcca 3446821 tgaagaccgg atgcacaaac ccaagtatga cagcaatcac agccgcagcc tttggatatt 3446881 gtttcttatg gcaatagaaa aagataaatg ataaaccttg gatgaaaatc agaaacccga 3446941 gtataaactc cccatttaaa gcgatagagt acagcatttg gcctttttct aaaggcaaaa 3447001 atgaaagcat gacaataatc aaatacagta ctacaacact ttgcggaaac ttcaactctc 3447061 taaaaggctt tagattagga atatcggggg agaatcgcct taagagcggc ttagcgataa 3447121 ggtaactgag gaaagaaaaa ataactccta ccatcacaat agctgttgga aaaagatatt 3447181 gaacgatacc caattgttct tccatcagtt ttaattgctt ctcaaactgc ccagcattgc 3447241 ccgactgctt cgctacagtt tctacaatat caagagattg ccggtattgt gtcattgcct 3447301 catcaatgat attgataccc aaaaactgaa tgcttatcac aaaatagaag acaatactaa 3447361 gcatataaat aagagcgccc gaaataatgg cgtgcccggg ctctttcctt ttgaaaaaat 3447421 gtcccatggc aatgccggcg caagctgaca taaaagctac aataagcccg ttaaaggacc 3447481 cgacaataaa aacaaccgga agactgacag cgcccatcca tatccctagc ttcaatccat 3447541 gtctgatcgt atacaagatc attggcagcg gcagtgcaaa taacagaatt gttccaatca 3447601 caggaacata aacgaccaga agcgtaatga tcgcaaacag actgattaaa atagcacctt 3447661 ccattaaagc tctcgtttgt ttcacttagt cacctcgtat catcctgaac atacgaatag 3447721 aaaagagcag cataaacgac tgctcttttg ttcatcgctg caacatgctt tgcaccgaat 3447781 gtttttatat catctctaaa ttttactttt atattttaac ataagtccaa atcgcaagta 3447841 aaatgacgct aatgtttcat gtgaaacatg aaaaaggaaa agacattctt tgaaaagaat 3447901 gcccatcaca attaatgttt atcatccata aagccagaag attccttgtt tttctttttc 3447961 gtttttctga catacataaa aattaagatc accagtaaaa gggttgttgc ttgcagaacg 3448021 ccgctgctaa acaagaaaaa gttctttatc atgtcccaca ttgtgtttca cctctttgtg 3448081 catgttctca acccgtatcc tatataaggt gaatttccct ttttaaaaac ttcaaaacat 3448141 catgaacaac attgagcgtt gggcatatgc tgatatggaa tctgatcgat aaaggagaat 3448201 tttcacatgg atgaacgcag aacattggct tggcatgaaa cattagaaat gcacgagctg 3448261 gttgcttttc aatcaaacgg actcattaaa ctgaagaaaa tgataagaga agtaaaagac 3448321 cctcagctca gacagcttta taacgtgtct attcagggtg ttgagcaaaa tttgagagag 3448381 cttcttccgt tctttccaca ggctccgcac agagaggatg aggaagaaga acgcgcagat 3448441 aacccatttt acagcggtga cctgctcggt tttgccaaaa catctgtccg cagctatgcc 3448501 atcgcaatta cagaaacagc aacacctcaa ttaagaaacg tactggtcaa acagctgaat 3448561 gctgccatcc agctgcacgc ccaagtttat cgatacatgt atcagcatgg atattatccg 3448621 tcttacaacc tttctgaact gttgaaaaac gatgtcagaa acgccaacag agccatttca 3448681 atgaaataaa acaagcagca aaggagttcc ctttgctgct atttctgctg atccttcact 3448741 aagccgttcg aacgataaga ttccagcacg tctctgttgg attctcccca ttctttcatt 3448801 tgcaaaacaa tcggttcaag cgtgcgccca aattccgtca gagagtactc taccttgggc 3448861 ggcacctggt gataaacctc acggtgcacg atgccgtccg cttccagctc cctcagctgg 3448921 agagtaagca ttctttgagt aatactcggg cagattcgcc gaaactcatt aaatcgtttc 3448981 ttgccatcta tcatgtgata aaaaagaatt cctttccact ttccgccaat gacatctaga 3449041 gtgaattcaa ctggacagcc ttctttgttc gggtatatat tctttttttc actcattctt 3449101 gaccctccaa tagtaccttt tttgatacta cattacattt tgcaactaat ctacccagta 3449161 ttttacacac cttttctcct tagctcaaag aaaatgcttc ttattcacat caatttttaa 3449221 gggtttgcat gattacacct gcagcaagac gtgttaaact atataaagat tacactactt 3449281 aaaaaaggat aggagctatc atggaaaaga tacttatttt cggacaccaa aacccagata 3449341 cagatacgat ttgttctgcg attgcttatg ctgatttgaa aaacaaactc ggcttcaatg 3449401 ctgagcctgt ccgcctcgga caagtcaacg gcgaaacaca atacgcgctt gactatttca 3449461 aacaagaaag cccgcgtctt gttgaaacag ctgcaaacga agtaaacggc gttatcctgg 3449521 ttgaccataa cgaacgccag caaagcatca aagacattga agaggttcag gttttagagg 3449581 ttatcgacca tcaccgcatc gctaactttg aaacagctga gccgctttac tatcgtgctg 3449641 agcctgtagg ctgtacggct accatcttaa acaaaatgta caaagagaat aacgtgaaaa 3449701 tcgagaaaga aattgccggc cttatgctgt ctgcgatcat ttctgattcc ctgttattta 3449761 aatctccaac ttgcacggac caagacgtag cagcagcaaa agagcttgcg gagatcgctg 3449821 gagtagatgc tgaagaatac ggcttgaaca tgttgaaagc aggcgctgat ctaagcaaaa 3449881 aaacagtgga agagctcatt tctcttgatg cgaaagaatt tacactcggc agcaagaaag 3449941 tcgaaatcgc acaagtaaac acagtggaca ttgaagatgt aaaaaaacgc caagctgaat 3450001 tagaagctgt gatctcaaaa gttgtggctg agaagaatct tgatctgttc cttctcgtta 3450061 tcacagatat cttagaaaat gattcacttg ctcttgcaat cggtaacgaa gcagcgaaag 3450121 tggaaaaagc gttcaacgtt acattagaaa acaacacagc cctcttaaaa ggcgttgttt 3450181 cccgtaaaaa acaagtcgtt cctgtcttaa cagacgcaat ggctgaataa gccattacaa 3450241 ttgcttcaaa atccttgcgg ggtttccgcc tacaacagta ttagcgggta catccttagt 3450301 gacaacagat ccagaagcaa tcactgcgtt atcaccgatt gtcactcccg ggttaatcac 3450361 cgcccggcct ccaatccaaa cttgatctcc aattgtcaca ggcttaccga actccttccc 3450421 ggatttcctt tcgatcggat caagaggatg accggccgtg tagatatgta cacctggcgc 3450481 aatcaaacaa tgacagccga tacgcacctc acacacatct aaaatgacac agtcaaaatt 3450541 aacaaatgta tgatctccga tatgaatgtg atagccataa tcacagcgga atgtcggcaa 3450601 aatcgtgact tgatccccaa ccgaaccgag cagctccttc aaaagcttcg tccgcactgc 3450661 atcatcttcc ggtgtttcgt tgtattgtct aatcagctgt ctcgcatgct tgcgttctag 3450721 taatagttgt tgatcttccg aattgtataa ttctccggct gccatttttt ctttttctgt 3450781 cctcagcatt taagtcactc cagatgtcag attgtaatct cgatcaaatt tccttcatca 3450841 tcctcaatca cgctttcata gtagccgtct cctgttgtcc tcgggccgtt tactactgcg 3450901 aaaccatccg ccttcaatcg atcagtcagt tcgtcaactt tctcccggct cccaacggaa 3450961 aaggcaatat gtgcccagcc tgtcattgtt tgtgagggcg gatcggtcac attccctttt 3451021 ttcataattt ccagccttgc tccggaatca aacgtaataa aataagactt aaaatctttt 3451081 ttctcattat gatacaaatc attcgcttcg ccattaaaat acgattcata aaaagacttc 3451141 attcgctcta aatcattgac ccagaccgct gtatgttcaa tctgcatttc ttcctcctcc 3451201 ttcgccttca atgaagttat aaggtatgaa atgcatttca gttcaagctt ttttcttaaa 3451261 tttatgctga attttgatat cagcgggttc atcctgcaaa aatagagaaa atgctgcgat 3451321 gccgagctgc tcaagattca aatcaagcga cggaaaacca agaacacggc tgatagaagt 3451381 atttccctcg cctatgattt caacatccca attattcttt ttggcaaata gatgaattcc 3451441 agctgccact tcatcactat ttgcataaat agcagtcgga acccgcccgc tcatataaaa 3451501 atgttcagct gccagctcac catcattcat atcgttgcat ccggacagca tatggcggtc 3451561 ttccaacctt ccgcagacag ctttataggc cgcagcttta tcagccgtgc tcgggctcct 3451621 atcagcttct ctgacacacg taaaagcaat attctcatgc ccgcggctct ttaaatagcg 3451681 aaagctctct gcataagcag tttttctgtc attaaaagca caagggacat caatgtctcc 3451741 ggtatcctca caagcgatga ccggcccata ttcctgataa gctaaaatgc tgtcccaatg 3451801 attggcgcgg gaagtaatga tgagaccgtc tattttcttc gttcttaaca gctctaaata 3451861 tttgatttca atatcggggt tataattggt ggggagaagg gtcgttgcat actcatgctg 3451921 aaaagccgcc ttggtgattc cgttaacgat tttatcaaag cagggatgat cgctataagg 3451981 cagaatcaca ccgaccgtat gggttttccc gcgaatgaga tcgattgcgg ttcgatttgg 3452041 tgtataatcc aattccttca tgacttgatg aacaagcttt ctcttttctt cagatacata 3452101 cggatgatga ttcaatacac gcgagacagt cgaaacagat acatttgcca gtcttgcgat 3452161 ctcttttata tttgccatct ctttctcctt ttcatataaa aaaagcagta agtgtaaaat 3452221 ccttactgct atctcatcat atattgatga taagttcaac aggacaatgg tcggaaccca 3452281 tgacgtccgc tgatatgctg gcatcttcaa tctgttcctt aaggctttca gaaacaacaa 3452341 aataatcaat ccgccatcca atatttctgt cccgggcgcc ggcacgatac gaccaccagg 3452401 aataagcgcc ttcaagatca ggataaacat gacgaaaaga atcaacaaag ccagcttcta 3452461 agaaacgagt gaatgcctct ctttcttgat ctgaaaatcc agcgttattc cggttcgcct 3452521 ttggattttt caagtcaatc tcctgatggg ctacattcaa atcaccgcat aaaatcactg 3452581 gttttttctg atccaattca agaatataag acagtaaagc ctcttcccat tgcatgcggt 3452641 aatcaatccg ctctaatccc cttctggaat tgggcgtgta aacagtcatc acaaacacgt 3452701 tttcaaattc cagcgtaatc actctgcctt cttggtcatg ctcttctact ccgataccgt 3452761 agatgacctg cagcggttct tgcttagaaa aaacagctgt gccggaatat ccttttttca 3452821 ctgcataatt ccagtacaca tgatagtctt caggctggag atcaacctgg ccgtcctgta 3452881 tcttcgtttc ctgaagacat ataatatctg catcctcttc tttcaaataa gagaggaaat 3452941 ccatttttct catcacagcc cgcaggccgt ttacattcca tgaaatcaac ttcatgtttc 3453001 atcctccccc ctataaaaaa gagcaagaac ccgaaggtcc ttgctcttta catatcagct 3453061 tactcaccgc ttacgtatgg aagtaaagcc atttgacgtg cgcgtttgat cgctgcagtc 3453121 aatttacgtt ggtatttagc gtttgttcca gttacacgac gtggtaaaat tttaccgcgc 3453181 tcagaaacaa actttttaag aagatctaca tctttgtagt cgatgtgcgt gataccgtta 3453241 gaagtgaaat aacacacttt acggcgtttc gcacgaccgc ctctgcgtcc tcctgccatt 3453301 gtcatttccc tcctttcttt ttcattttag gcgataatca cattagaatg gaagatcatc 3453361 atccgagatg tcaatcggtt tgccgtcgtt ggcaaatggg tcatcattaa agctgttccc 3453421 ctgattgcgt ctctggttgt tttgatttcc cccaaatgga ttatcatttt ggcctccgcc 3453481 aaagtactgg cctccgccgc tgtttccttc gttgtatcca cctgaaccag aaccgccgcc 3453541 gtttttcggc tcaagaaatt gaacactttc agcttggacc tctgtcacga agacacgctg 3453601 tccttgctgg ttttcatagt ttcttgtttg taaacggcca tctacgcctg caaggcttcc 3453661 ttttttcaag aagtttgcaa cgttttcggc ttgtcttctc caagtgacac aattaatgaa 3453721 atcggcctca cgttctccgg actggttcgt aaatgtacga ttcacagcaa gagtaaacgt 3453781 agcaacagcc gcaccgtttg gcgtataacg aagctctggg tcttttgtca gtcttccgac 3453841 taatacaact cggttaagca taagaaagac caccttttac cattatatat ttcaaaattg 3453901 cttattcttc ttctttaaca acaatgtggc gaatgatatc gtcactgatc ttagctagac 3453961 ggtcaaattc ttgaactgcc gcagcgtcag attgaacgtt tacgatttgg tagaaaccgt 3454021 cgcggaaatc gttgatttcg taagcaagac gacgtttacc ccaatccttt gttccagtga 3454081 tctccgcacc gttagaagtc agaacgttgt tgaaacgctc gataactgct tttttagact 3454141 cttcgtcaat gtttgggcgg ataatgtaca taacttcgta ctttctcatc tgtttgcacc 3454201 tccttttgga ctaagcggcc cataatgggc aaggagcaat aattctatta ctcacaattt 3454261 tatattatac caaagctctt gtccctttac aactgcatcc tatacattaa atcggaaatg 3454321 aataacatct ccgtcttgga ccacatattc tttcccttca aggcggactt ttcctgcctc 3454381 tttagctcct gccataccgc cgcccgcaag aagatcctca taagcaactg tctcagcacg 3454441 aatgaagccc cgctcaaagt cactatgaat aattcctgca cactcagggg ctttcatgcc 3454501 ttttttgaat gtccaagctc tgacttcctg ttctccggct gtgaaatatg ttgcgaggcc 3454561 gagaagagag taagacgctt tgatcagctg atcaagacct gattcttgaa tgcccagctc 3454621 ttccaagaac atttgctttt cttcgccttc aagctcagcg atttcagatt cgatttttgc 3454681 acacacaacg ataacttctg cgttttcgcc ggcagcgtac tcgcgaatct tcgctacatt 3454741 ttcattgcca gatggatcag caacttcatc ttcacttacg ttggccacgt acaaaatagg 3454801 cttcgaagtc agtaaatgga gctgcttcac aagcttttgc tgctcttcag tgaattctac 3454861 agatcgagca ggcttttcac tctcaaacgc ttctttcagt ttagataaaa tctcaaactc 3454921 aaatacagcg tctttatctt tttgcttcgc aagcttgctg acgcgtgtaa tccgcttttc 3454981 aactgtttcc atatcagcga ggatcagctc aaggttgatc gtttcaatgt catcaatcgg 3455041 atcaaccttt ccggaaacgt gtgtaatgtt gtcatcggaa aaagcacgga caacgtggca 3455101 aatcgcgtca acttggcgaa tatgagatag gaacttgttg ccgagtcctt ctcctttaga 3455161 tgcgcccttt acaatccctg caatatcagt gaattcaaaa gcagtcggca cagtcttctt 3455221 cgggttgacc agctcagtca gcttttgcag acgatcatcc ggcacctcta caattcccac 3455281 gttcggatca attgtacaga acgggtagtt ggctgattcg gcaccggcct gtgtaattgc 3455341 gttaaatagt gttgattttc cgacgttcgg caaaccaaca attccagctg ttaaagccat 3455401 tctttcatct cctctatata aaaccgtcat tgtatgaacg tattttgaac ctagagcaat 3455461 tataaggagg ttcactggaa aagacaagct gacaaaaaag cattttcagc ttgccaatcc 3455521 ctttgattat gcttttttca agcctactaa acagtcaaaa agcgtacttc ccattccatt 3455581 atcagaattt gtatcatttg tcagtgcatt gactgaccct ccaaaagccg cccacatgcc 3455641 ttcatctata ttaatcgtct tcgcatgagc ctgcttcatc actttcacct tgcccttcat 3455701 gcttccgcgg tcattaaaga tgacaacttc gtctccatcc tgaagatcct gcccagccgc 3455761 tatatctgga gaaatatcga cctgaacgtg ctgaagcttt tcaataaacg gcacatgctg 3455821 tgaatgattg gaacgctgcg gatgaatgga taagagcgta taagggtact ttccagctaa 3455881 ctcctcatta tggaaaacag attcttcggg cacatttaat tgaagcgagc cgctaaatcc 3455941 tttttgctca gctagcgacg aagtaaattc aaattttcca ctcggcgtca aaaactgata 3456001 atcatcccac ggcacctgtt ttactggaag agggaggtgg cctttttctt ttaaacgctc 3456061 aagtgtcaca tcctctgctt ccaatgaaga aagccccatc tctaaaaatt cttgagtgct 3456121 gtattcaaac agctcgccaa acccaagacg ttttgcaagc tctgaccaga tccagctgtc 3456181 cgatttcgct tcaccctgcg gctccacaag cttcttcccg tactgaacat aatgatgata 3456241 catactggaa tagtagatat cttcttcttc aaaaacagtg gcagtcggca aaacataatc 3456301 acacagctct gcggtatccg tcataatgga atcaatcgcg accgtcattg gaaccttttc 3456361 aaatgcttgt ctcaccttat ttgtattcgg cacctgagtc agcggatttc cgcacgtcac 3456421 aataatcatc tcaatcgcag gatcagcagc ggtcaacact tcttcagcct gtgtcatcat 3456481 tgaaaaagaa cgggatgttg tttttaattc cggcagcgtc agctttgttt ttgcaaagct 3456541 ctcaccaatc tggacatttc cgaaattcgc gccgccgccc ttaattccga catttccgct 3456601 tgccgccaca agtgcatcaa tccaacgaat cgttcccccg ccgtttttat atcgctgcat 3456661 gccaagcccc ataaaagtag acaccggacc atcagcatac aaacctgcca aatactccag 3456721 ctcctccata gaagtttctg ttttcacaat aaactcttcc agagaaacgg tcttcaaaag 3456781 ctctttcaca tcatcaaaac cgacagaatg ctcagaaata aacgtttcat ccgttcttcc 3456841 catctcaatc agaaccttca aaacggctgc cgcaagccag ccgtccattc caggctttac 3456901 agagatatag cggtcggcaa gcttagcagt cgggttgaag atcggatcaa tcaccgtaat 3456961 cgtggcgccc ttctttttca cctgctgcaa gtgatggtat aagtgcatat ttgttcttga 3457021 tacatttctt ccccacacaa caacatgctt gctgttgtaa atatcaagcg gtccgtgacc 3457081 gtacgaacgg ccaaaatccc agctttgcgc ctcgataccg gagccccagc atatgcttcc 3457141 gacgatttcg gtcacgccgc catatccatt aaaaaaacgc tgatcaagcg cttttaacag 3457201 accgttattc gcataatcat ggctgtgcaa aacagcagtc gtctccgacg tttccttgat 3457261 ttcccgaagt ttatcggcaa tttcatcaag tgcctgctcc caagaaatcc gcacaaactc 3457321 gccattttgt tttttcattg gatagcgaag ccgatcaggc gaatttgttt ttgtctcaag 3457381 cattctgccg cggccgcaga ttttaccttc cgtaatcgga tggtttggat ctccgtccac 3457441 ttttgttacc tttccatcat caacagtcac caaaaagccg cagctgtccc aacaattcag 3457501 cggacatgcc gactgatgca ctttgctcat cgccgtcttc tccttacctt ctatatgaaa 3457561 aagcatgagt gtcggcctat ttatgaagta ggctcctcat gcttgactag tacttttttt 3457621 agttttcttt caaattctct tctcggaatc ataacactgt gagagcatcc ctcacactta 3457681 attcgaatat ccattcccat gcgtataatt ttccagctgt tcgctccgca tggatgcggt 3457741 tttttcattt ctacgatatc attcaggcca aagtctttat ccgccaagac ccttcacctc 3457801 ttttcctaaa ctgctgtatc tattgtacaa aaaaactgat cataagagca atcaagatac 3457861 ccgaaaagaa atacatcctc ttatttccat ttactcaaaa taggatataa gagcagacaa 3457921 actaacaaat acaaattgag catcccatat atcggataca agaacgcgat caaatcagaa 3457981 aatccgaaag aagtaaaagg taccattaac actaacaaaa tcaacacaat catccatctc 3458041 ggcatatgaa taaacgccat cagccggctg gacaaaccca gcaaaccagc taccgtcgtc 3458101 gtgtaaatcg ccaggcacag caccgccgtc atacataaaa aaaggaaata aggcgcaccc 3458161 tccagaacgg caaacagcgg tatttcaaac tgagaaaggg agcccgccag ctccaccaac 3458221 gtttcattat aaacaaatga gatcacgcca aaaataagac cgcttgccac acttgcgatt 3458281 tttgcttctc cgagcccttt catctctttc ccaacagagg ataaaatcgc aacaactgaa 3458341 aggatgttta aagaggtaaa cgtaatgctc gcaggccagt tatactgctg ggacaaatca 3458401 atcgtccacg tatggtgatg tgtgctctga aaggagatca gcgcatataa aagccccgct 3458461 actaacacag gaatcaaaat actatttata gataatattc ctttcacatc ccacaaaaac 3458521 aagcacactg tcacgatgca aatcagcgtg attccccacc agaaaggaag cttgtacatt 3458581 tgcagggtca caccgcctcc ggcaatcatc accatagtcg tcgaaaacaa ataaaaaatg 3458641 atgaggacat cataaatttt cgccagccat ggccccatta aatgctccag aaccggcaga 3458701 aaatgagtgg attgaacctt aaaactgatt ttcatcacaa tataagacga gaaaatgaac 3458761 ataattgtaa acagcacaat agcaagtccg ctttccgccc caaaaaactg ccatatctcc 3458821 tgaccgctcg catatccggc cccgatcagg ctccctaata tgagcagcat ccacttcatt 3458881 ccggctctcc acaacactat cacctcatag acaaagttca gcttgttccc gttattgtta 3458941 ctatataaat aaaggaaagc aaacatgcca tattttcata gacatttgaa cacaagctga 3459001 aattatcata cgaaatacac ataaaaaaga ctgctaatac ggcagtctaa aaagagatat 3459061 ttatttgttt gtccgcggaa tgaagaagtg aacttcactc ttcacttttt tctaaccatt 3459121 cctacctatt caagtgtttc ataagcagac cattgcttga tcatgatcga ggcaatgggg 3459181 gacaatactt gtaatcgccc actaaccatt catatcatgc cctctacttt tttaaaatct 3459241 ctggtgccat acacaaagca taaaaaatca tactgctgga tatactgtaa acaaccttac 3459301 ataactacac acaccatagc aattctgtta cctactataa caaggaagtg aaacccatga 3459361 atcgaaaagg cgggcttttt tcttctcagg aacgagtaaa gcaatatgtt tcacatacag 3459421 atgctgcagc ggcaaaacaa atccaaacca tcctttcttc atccttacgt aaagctgctg 3459481 gcaaaccaat tgtcgtggtt tgtatcggaa cagaccgttc aaccggtgac tcattaggcc 3459541 cgctcgtagg aatgaaactc aaacagatgc agctcaccag attccatgtc tacggaacct 3459601 tatctgaccc cgtccatgct gtgaacatga aggataaaat caatgacatt cataaattac 3459661 ataaaaaccc atttgttata gcagtcgatg catgcttagg ccgcgttaag agtgtgggtt 3459721 catttcaaat cggggacggg ccattaaagc ccggagccgg tgtacaaaaa gaccttcctg 3459781 aagtgggaga tcttcatatt aacggaatcg tgaatgtgag cggttttatg gaatattttg 3459841 tattgcaaaa tactagactc aacttggtca tgaatatggc aaatgttcta gcggaaggtt 3459901 tgagtttaac agatcggaca gagtggaggc aagaacgcct taacccgttg caaaggctca 3459961 ctgggcgcat ataaaataaa aaccatcttc gtttgaaaga tggttttttc atttatgatt 3460021 ctcgttcaga caaaagctct aaaatccggt caaggtcttc attagagaaa aattcaattt 3460081 cgattttgcc ttttttcttc tgtcttttaa tattaactgt tgttccaaaa taattttgga 3460141 gataggattc ccgttctttt agaaccgcat ctttcacagg ttcttttttc tttgtttcac 3460201 gtggaacatt ctgattcaac tgctgaatca gctgctcaag ttggcgaaca ttgagctgct 3460261 ccgcaatcac tttttgtacc agcggttcaa gcttattttt gttttttaag ccaagaagcg 3460321 tgcgtccatg tcccatagaa agcgtgcctt cggcaataag ctgttgaata ttttctggca 3460381 gtgtcagcag tcttaaatga ttcgcaatat gcggtctgct tttcccaaga cgtttggcaa 3460441 gctgctcttg tgtgagatct aagtgtttca aaagggagtc atatgcctga gcctcttcaa 3460501 gcggagataa atcttcacgc tgaaggtttt ctaataaagc aatttccctc attaacgcct 3460561 ctgataattc acggacaatg gccggaactg tatctaaacc tgccagcttt gccgctcgaa 3460621 aacgccgttc acccgcaaca atatcatagc cttttaaaga ttttctgacg ataagcggct 3460681 gaagaatgcc atgctgcagc acagattctt ttagttcagc taatgcctcg tcatcaaagt 3460741 gttttcttgg ctgataagga ttagggcgta aatcggcaat tttaatttct tcaactgtct 3460801 cttcagacaa atctacctga ttaaataacg cattaatccc ttttccaagg cctttagcca 3460861 ttcgcagcca cttcctttgc taaatctaaa tatacttccg cacctcttga ccgcggatcg 3460921 tataaaatga tgggttttcc gtgactcggt gcctcactca gacggacatt acgcggaata 3460981 actgtcttat atactttatc cctaaaatac tttttaacct cttcaatcac ttgaatgcca 3461041 aggtttgtcc gggcatcaag cattgtcagc aatacacctt caatcattaa atcagtattc 3461101 aaatgctttt gcacaagacg tactgtattt aataactggc tgagaccctc caaggcataa 3461161 tattcgcact gtacaggaat cacaacggaa tccgaggcag taagggcatt aatcgtcagc 3461221 aagcccaatg acggcggaca atcaatgata atataatcat aattttgctt tactgcttca 3461281 agcgctctct tcaatctcac ttctcttgat attgtaggaa ccagctcgat ctcagcccct 3461341 gcaagctgaa tcgtcgcagg aatcacatcc aagttctcta ctgtcgttgc tttaataata 3461401 tctattacat ctgcatcatc tactaaaata tcgtacacac actgctctac atcggctttt 3461461 tcaatcccta atccgcttgt cgcatttccc tgcggatcaa tatctaccag cagaaccctt 3461521 ttccctatgt aagccaaaca tgccccaagg ttgacagacg tcgttgtttt gccgaccccg 3461581 cctttttggt tcgtaattgc tatgattttt cccacgatgt cacctacttt cacatgaaca 3461641 tgtactatct tgcttctatt ctatcaaaaa aagattaaag cgtttcattt ttttcatcat 3461701 tttgttccga atcagaaggg aaataattga aaattcaagc acgctttatg ctttctctta 3461761 taaattctgc aatttctatg tttttttgac ttaaaaaagg aatttcttaa agaaaaaaag 3461821 aagaagtcac agtacagaac gtggaaacag gatggtgaga aaatggttta tcaaacgaag 3461881 agagatgtac ccgttacgct gatgattgtg tttctcatat tactgataca agcagatgcc 3461941 attgttcctt ttgtgctggg aaatatgaga gtttccggct ggatcatttt tattctgctg 3462001 actcttttaa atggactcat catttggagc tttattgacc taaaatatgt attgaaggaa 3462061 caccatctga tcattaaagc cggattgatc aaacatcaaa ttccttatga aaacatcgat 3462121 aaagtcgttc aaaaaaagaa actatggtcc ggttttcgtc tgatcggctc tcgccatgcc 3462181 atcacaatat attatcaggg gggatgggga catgcagtaa tttcaccgca aaaatctgaa 3462241 gaatttatcc acaagctcaa agaaaagaat tctaatataa taatattcac taaaagtaag 3462301 tgattacctt ttgttaaaaa tataaaaagc tctcctgctt ttcaggagag cttctatttt 3462361 ggtatgcgaa tcgttaattg aatatattct tcaaattctt cttcttccgt attcaatttt 3462421 acaccgctgt cttccaccat tgatagtgac tggcgaatcg tgttcatcgc aattcttgta 3462481 tctctgctga atgctttgcg tctcggcttt ggctttctct ggccttgctc cagcattttc 3462541 accacgcggt cttctgtctg ctttacattt aaacttttct caataatctc tgtgagcagt 3462601 gtgacttgga gctcaggctg tttcagcgga atcagtgctc tggcatggcg ctcggtgatt 3462661 ttcttctcca taatcgcctc ttggaccggc tgaggcagct ttaataaccg aagcttattc 3462721 gcgattgtag actgcccttt tcctaagcgc tgtgcgagtg cctcctgtgt taaatcatgc 3462781 agctcaagca gcctagcata agcatgcgct tcctcaatag aagacagttc ttcccgctgc 3462841 aagttttcga ttaacgccac agaagcggtt tccgtgtcgg aaaaatcctt aataattgcc 3462901 ggaatctttt cccactcaag cgattgcacc gctctccagc gtctttcacc tgcaatgagt 3462961 tcgtattggc cttcttcttc tgtatgccta acaacaatcg gctgaataat gccgtgtgta 3463021 tgaatggtca ttgctaactc tttgattttt tcatctgaga aaatggtgcg tggctgaaaa 3463081 cggttgggaa cgatagcatt taccggtatt tccagaatct cttctttgtt tgtatcatgt 3463141 tcagcaatct ccggctcctg ttccttctca ccaagcccga agaaacgaga gaatgaatgc 3463201 ttcatgtacc tacaccacct ttaaaaactg ccatttttat aattctattt tctcatggtt 3463261 tttcctgctg tacatccatc aattttgatg aaaatatgat ggtattgtca tatcaggctg 3463321 tctaaattac ccttcaattg gcgatttatt aggagttccc ggttttcttg gatacttctt 3463381 aggtgtattt tttattttgc gtatcaccat aatattacga tcgctttctt caataggcag 3463441 cttaaaagaa tggatattct caagttctcc tccaagcgtc gtgattgctt ttttgcctgc 3463501 attcagttct tcttcagctg atgcggcttt taaagcaaca aataaaccgt ttttcttcac 3463561 cagaggcaag caaagctcac tcaaaacaga taatctcgca actgcgcgcg ccgtcacaat 3463621 atcatagctt tcacgcacgt ctttccgttg cccgaacgtt tcagctctgt catggcagaa 3463681 tgttgtattc tccaattgca aagcttcaga caacttttct aaaaacgtaa tccgtttgtt 3463741 tagtgaatcc acgattgtga catggaggtg cggaaagcat atttttatcg gcagacttgg 3463801 aaaacccgct cccgctccaa catcacaaat cgtgttcacc tgattgaagt cgacataaaa 3463861 agcagctgta atggaatcat aaaaatgctt taaatacact tcttttttct ctgttattga 3463921 agtcagattg attttttcgt tccattcaac cagcatgtcg taatacagct caaattgctc 3463981 cagctgacgg ggagaaaggg agatcccttt ttccgccaaa ccagaagtga attcttcaat 3464041 attcatgccg tcatcctttc tactcggcta tcttcgcaat gcgtccctgc tctaaataca 3464101 ccaatagaat tgaaatgtcc gccgggttta caccggaaat gcgggaagcc tgggcaacag 3464161 acaaaggccg tacatttttc agtttttgac gcgcctcggt cgcaatcccc ttaattgcgt 3464221 cataatcaat tcggtctgga atttttttat tttccatctt cttcagtttt tccacttgct 3464281 gaagagattt ttcaatatat ccttcatatt tcacttggat ttctacttgt tctgccacgt 3464341 cttgaggaac cggcacttct ggcggcgcca gttttgtgac tgtttcatag ttcatttcag 3464401 gacgtttcat caagtctgtg ccgcgaactc catctttcaa ttcgcttccg ccaagagaac 3464461 ggatatattc ttgattttcc ggagacggct tgataattac agaatgaaga cgttttttct 3464521 ccgcctcgat cgccgctttt ttcttctcaa aagccgcata gcgctcatca gaaatcaatc 3464581 caatgcgatg tccgatttct gtcagacgca aatcagcatt gtcatggcga agcagcaatc 3464641 tgtattccgc acgtgatgtc aaaagacgat atggctcatt ggtacctttt gtcacaaggt 3464701 catcaatcag aacaccaata taggcgtcag aacggcttag aattacttct tcttttccaa 3464761 gcgcttttcg tcctgcattg attcccgcca taatcccttg tcccgcagct tcttcataac 3464821 cggatgttcc gttaatttgg cctgcagtat aaaggtttgt gatttttttg gtttcaagtg 3464881 tcggccatag ctgtgtcggt acgattgcat catactcgat cgcatagccg gctctcatca 3464941 tttgcacgtt ttcaagtcca ggaatcgttg caagcattct ttgctgtacg tcttctggaa 3465001 gacttgtaga taaaccttgg acatagactt cctgtgtatt tctgccttcc ggctcaagga 3465061 agatttggtg acgcggttta tcattaaaac ggacaacttt gtcttcaatg gatgggcagt 3465121 atcttgggcc cgtacctttg atcataccgg aatacatcgg tgaacggtgc aggttgctgt 3465181 caataatctc atgtgtctca gggcttgtat atgtcagcca gcaagggagc tgatctgtga 3465241 tatattccac tgtttcatat gagaaagcgc gaggcacatc gtcaccaggc tgaatttccg 3465301 ttttgctgta atcaatcgtg tcgcttttaa cgcgaggcgg cgtacctgtt ttaaaacgaa 3465361 caaggtcaaa accgagttcc tccaaatgct cagaaagctt aatagaaggc tgctggttat 3465421 tcgggccgct tgagtaagac agatcgccaa gaatgatacg tcctcttaaa tatgtccctg 3465481 tcgtcatgac aactgctttc gcacgataat gtgcgcctgt ttgtgtaata acgcctcggc 3465541 attcgccgtc ttcaacgatc agccgctcca caattccttg cagcaatgtt aagtttggtt 3465601 ctttttcaag cgtatttttc atttcgtgct gatattggaa tttgtctgct tgcgcacgca 3465661 atgcacgaac cgcaggacct tttcctgtat tcagcattct catttgaata tgtgttttat 3465721 cgatgtttct tcccatttct ccgccgagcg cgtcaatttc gcggacgaca atcccttttg 3465781 cggggccgcc gacagacgga ttacatggca taaatgcaac catatctagg ttgatggtca 3465841 agacaagcgt tttggcgcct tggcgtgcag atgcgagggc agcctcaaca ccggcatgcc 3465901 cggcgccaat cacaatcaca tcgtattggc ctgcttcata ccccatgatt ctagttcctc 3465961 ctttaattat tttcctaaac agaattgaga aaagagctga tcaattaagc tttcgtggac 3466021 agaatctcca atgatttccc ctaaaagctc ccagcatctt gtaaggtcaa tttgcaccat 3466081 gtcgatcggg acatcctgtt cgatgccgct aagcgcatct tcaatggcgc gttttgcttg 3466141 ctgtaaaata gtgatgtgac gtgtgttgct gacataagtc agatcaccgc tttcaatggc 3466201 acccgtgtag aacagtgatt gaatcgcttc ttccagatca ttgatgcctt cctcttttaa 3466261 aagagatgtc gtaacaactg gacgtccatt ggcaagctca cggacacgtt cagtgtcaat 3466321 cttcggctca aggtcagtct tattcaaaat cacgataaca tccatgccct caacggcttc 3466381 aaaaagcttc acgtcttctt cagaaagctc ttcactataa ttaagcacaa gtaaaatcag 3466441 gtccgcttcc tttaggacct ggcgagaacg ttcaacaccg attcgctcaa caatatcctc 3466501 tgtttcacga atacctgctg tatcaaccag acgaagcgga acgcccctta cattcacgta 3466561 ttcctcaatc acatcccgtg tcgttccggg aatatcggtt acaatggctt ttgcctcatg 3466621 aacgaggctg ttcagaagag atgattttcc tacgtttggc cggccgataa tgacggtaga 3466681 aagaccttca cgcaagattt ttccttgctc agaagtcctc agcagcgtct caatttcctt 3466741 tttcacggcg gttgcctttt cgactaaaat ctgatgcgtc atttcctcta catcatcata 3466801 ctccggataa tcaatattca cctcaacatg ggccagtgtt tctaaaatct cactgcgcaa 3466861 acggcgcacc aaagcagaaa gacgcccttc catttgattc atagcaacgt tcattgcccg 3466921 gtccgttttc gctctgatta agtccataac cgcttccgcc tgtgaaagat cgattcggcc 3466981 gtttaaaaac gcacgtttcg taaattcacc aggctctgcc agtctcgctc cctctctcaa 3467041 tgcaagctga agcacttggt tcacagtcac aattcccccg tgacagttaa tctcgatgac 3467101 atcttctcgt gtaaaagttc tcggcgcttt taacactgat accattactt cctcaacgac 3467161 acgatccgaa ggtctgtcta cgatatgacc ataatgaatc gtatgtgatt cgaccgagct 3467221 gagtgttttc cccttcggtc ccttataaat tttatctgcg atttgaatgg cttctggtcc 3467281 gctcaaccgt acaatcgcaa tcgcgccttc tcccatcggt gtggaaattg ccgcaattgt 3467341 atccatgttg ttcacctctc tttacttata cttcatctat ataaaaaaat ttttattatg 3467401 ccaaaactaa aagataacat agtttggttc gaagtggaag atttgttatc cacagaaata 3467461 gaaattcgtc ccttattact ttaacttatc cacatgtgaa taacaattaa ttttatttcc 3467521 tgaacttcct ttttatcaac aggatacacc taaaaagaaa aaacttaaac ggcaaaacct 3467581 tgatattact aggaaaagta gatttttcgg atacaaaaaa accgaaatcc aatttttatc 3467641 ggacttcggt tttatgctat cttttatggg aaataacgag atgacgattt tcgccttcac 3467701 ccattgaata tgttttgatc tggtggtttg catatccaga aagagtatcg tgaataattt 3467761 ttctttcgct ggacggcatg ggctcaagct ggatggattt tttcgttttc aaaacctggt 3467821 cagcaagctt gatggccagc tggctcagtg tttcttttct tttcaaacga tagttttctg 3467881 catccaccgt cacattttta tattggcctg gataacggtt aagggcaagc tgtgtcaaag 3467941 tttcaagggc gtttaaagtt tgtcctcttt tcccaatcaa caatgctgcc ttttcacctg 3468001 ttatatgata tctcactgtc tttttgcttt cttgaacagt cacatcagac ttcccggcaa 3468061 tggcttcggc aatcgtttga agatataact tcgcttgctg aatcggatca atcttttcaa 3468121 ccagctttac gatcgcaggc tttttaccga aaataccgag aaaccctttg tttccctctt 3468181 caataacagt aatttctacc ttatccttcg ttaatcccaa ctcttgcaat ccggactgta 3468241 ctgcttcatc gacatttcgc cctgcagcag tcacattcct cactttttct ttcctccggc 3468301 tttttgcggc tcaggatttt ttttaatatc aggtccttta atgaggaaag tttgcgcaat 3468361 cataaacaag ttaccaacta cccaataaag agaaagagcc gccgggaagt tgatcgcaaa 3468421 tacgataatc ataattggca taatccaaag catcatcgcc atttgcggat tttgctgcgc 3468481 attgccagcc atcatcagtt tttgctgaac aaatgtagcg acaccggcaa cgataggaag 3468541 aatatagtaa ggatcttttt ctcctaagtc aaaccataag aagctatgct ctgaaatcgc 3468601 ctgggttctc atgatcgcat gatagaatcc aattaaaatc ggcatctgga tcaaaatcgg 3468661 gaaacatccc gccaatggat tgacaccatg cttttggaat aaagccattg tttcctgttg 3468721 aagcttttgc tgcgtttttt gatcctttga gctgtatttt tctttaagct tttgcatttc 3468781 cggctgtaaa gcctgcatcg ctttcgaact tctcagctgc ttaatcatca gcggtaaaat 3468841 taataaacga attaaaatgg taactagaat aattgaaagc ccgtagttat ctcccgtcaa 3468901 tttcgctaca tacgtaatga gctcagacaa tggatatact acgtacttgt cccagaaatg 3468961 cggactatct gcagtgatcg gctctttcac actcgagcat ccagccaaaa gcatgaatac 3469021 gccaaccata cttaatagca accctattct ccttttcaac aacatttcct cctataatta 3469081 atctttacac tcttttattg caaagcatac ttgtatgtat tttagcatct ttcagtttta 3469141 aatggtgtct ttttctgatc aaccagaaag gaagcgcttt taaaagttgt aagaaagcag 3469201 tggtgatgcc tactttgacg aagatttctt atataatgaa gactttctga atagatgctg 3469261 cagacttttt ttcgtttcct catatgtcag ctggctcgcc ggttttctgg caataatgat 3469321 gtaatccttt tccttcagtc tctctttctc ttcaagaaag gcctgccgaa tcaaacgttt 3469381 gatccgattt cgcatcacag cattgccaat ttttttgctg acggaaagcc cgacacgcag 3469441 ttcatcattt tcaggctgat caagcgtata taagacaaac tggcggtttg caactgatgt 3469501 cccatgttta aacacttttt gaaaatcttc atttttcttt aaacgatttc gcttcttcaa 3469561 atgactcact ccgatactgg ctggcagaaa cttttaaaat ttattatgaa catgagatgc 3469621 atctgaacca ggaagcatgc cccggttcat tacgcatcac atctatcttt tcccataacg 3469681 tgaaaaaaga ccactgacat tattcagtgg cctaagctga taatactttt ctgcctttgc 3469741 ggcgacggcg tgctaaaact agacgaccgt tttttgaact catacggctt ctgaagccat 3469801 gaactttgct gcgtttacgg ttattcggtt ggaatgttct tttcatttat gacacctccc 3469861 tcgaggaata gctgttaaag acagtcttac ttattatatt tgcgttacct attcattgtc 3469921 aacttcacta gtgcttttat ttcttgcaac cataatagga taccatacct tttcaacttt 3469981 cgaaacctta ttttttagat tccttaattt tacggaaaaa agacaaattc aaacaatttg 3470041 cccctaaaat cacgcatgtg gatatctttt tcggcttttt ttagtatcca cagaggttat 3470101 cgacaacatt ttcacattac caacccctgt ggacaaggtt ttttcaacag gttgtccgct 3470161 ttgtggataa gattgtgaca accattgcaa gctctcgttt attttggtat tatatttgtg 3470221 ttttaactct tgattactaa tcctaccttt cctctttatc cacaaagtgt ggataagttg 3470281 tggattgatt tcacacagct tgtgtagaag gttgtccaca agttgtgaaa tttgtcgaaa 3470341 agctatttat ctactatatt atatgttttc aacatttaat gtgtacgaat ggtaagcgcc 3470401 atttgctctt tttttgtgtt ctataacaga gaaagacgcc attttctaag aaaaggaggg 3470461 acgtgccgga ag //